LOCUS 031_IIG_Bs27_009_SNP 3618444 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1e9-cvskbti VERSION urn.local...1e9-cvskbti KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3618334..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 569976..569977 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(570515..570526) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570523) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(570540..570546) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 570601..570608 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570622..570641 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 570624..570724 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 570626 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(570672) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 570684 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 570692..570699 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570713..570732 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 570728..570815 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 570728 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 576184 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 576288..576292 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576308..576327 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576312 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 579968 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(580251) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 581914..581933 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 581924 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 581926..582115 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 582080..582087 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582101..582120 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582117..582287 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 582117 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(582182..582201) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582194) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582215..582222) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 583274..583374 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 583334 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 584390 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(584465) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 585028..585033 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585048..585066 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585050 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585369..585370 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 585380..585394 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 585402 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(585407..585426) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585424..585532 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(585427) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585440..585445) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 585506..585512 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585526..585545 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585534..585608 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 585534 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 587575..587667 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 587624 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 587669..>588895 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(588895,588902) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 588896..588901 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(589022) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(591503..591522) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(591529) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(591536..591543) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 591592..591593 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 591608..591690 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 591608 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 591609..591628 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 594244..594251 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594265..594284 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 594270 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 595259 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 595399..595408 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 595415 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 595421..595436 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 596154..596218 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 599000 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 599044 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(600114..600133) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600132) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(600147..600153) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 600342..600349 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 600362 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 600364..600666 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 600364..600383 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 602080 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(602136) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 602716..602725 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602739..602758 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 602740..603275 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 602740 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(603177..603471) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 603276..603295 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 603277..603574 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 603277 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(603466..603480) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(603471) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 603573..603592 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 603576 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 603972 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 605072 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(605148) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(605347..605479) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(605390) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(605722..605741) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605733) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 606414..606423 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606436..606455 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606436 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(607454..607472) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607462) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607488..607493) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(607611..607626) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607632) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607638..607647) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(607700) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(609259..609278) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(609273) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(609292..609301) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(609394) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(610830..610849) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(610844) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 611120..611127 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 611143..611162 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 611144 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 612024 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(612299) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 612353..612372 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 612363 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 616797..616804 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616819..616838 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616835..616964 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 616835 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 618492 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 618613..618617 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 618633..618652 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 618643 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 618778 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 620187 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 620230 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 620259..620268 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 620279..620419 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 620279 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620281..620296 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 621208 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 621291..621298 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621312..621331 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621318..621381 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 621318 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 621556 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 621600..621606 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621621..621639 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621624..621710 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 621624 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 621689..621696 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621710..621729 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 621712 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 622504 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 622560..622567 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622582..622601 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622584 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 622697..622836 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(624762..624781) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(624783) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(624796..624803) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(627710) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 631097..631197 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 632245..632259 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 632254 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(632521..632539) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632528) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632555..632560) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 635626 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(636170..636189) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636179) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 637467 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(637544) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(637761..638181) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 637828..637833 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 637844 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 637847..637866 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(638166..638177) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(638181) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(638191..638197) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 638212 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 639605..639611 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 639623 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 639624..639643 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 640833 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 640975 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(641019) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(642596..642615) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(642615) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(642630..642636) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 642779..642782 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 642796 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642799..642818 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(648055..648059) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(648059) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 649087..649106 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 649095..649211 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 649095 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(649159) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(649229..649329) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(649269) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 650205 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 650249..651053 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(650281) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(650978..650996) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650999) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651012..651017) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(651079) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(651931) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(651934..651947) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(652544..652674) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(652665..652683) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652674) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652698..652704) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 652805..652808 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 652823..652956 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 652823 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 652825..652844 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 656145 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(656221) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656838..656843 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 656859..656877 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 656871 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(657049..657123) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 657101..657108 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(657117..657136) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657123 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 657124..657143 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657130) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657151..657158) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 660325 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 660577..660580 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660595..660614 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660603 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 661573..661827 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 663208..663800 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 663757 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 663802..664102 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 664439..664512 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(667404..667419) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667419) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667431..667440) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 668964..669075 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 670225..671414 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(671317) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(672146..672165) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(672153) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(672178..672183) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(673815..673834) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673825) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 675122..675129 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 675143..675162 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 675144 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 676432 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 676478..676582 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 676549..676556 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 676571..676590 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 676584 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(676639) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 677214..677221 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677235..677254 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677245 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 677338 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 677425..677434 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677448..677467 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677451 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(677455..677473) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(677475) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(677489..677494) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(677497) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 677927 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 677987..677994 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678010..678029 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 678015 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 678607 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 680067..680072 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680088..680106 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680088 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(680110..680124) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680115) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680132..680136) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 681212..681290 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 681263..681268 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681283..681302 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681292 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 681845 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 682246..682254 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682265..682283 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682271 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 685737 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 685822..685825 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685840..685859 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685847 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 694499..694599 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 694559 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(695097) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(695098..695117) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(695130..695139) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(702381..702399) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702394) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702415..702420) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(705591) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(705617..705717) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(705657) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 706921..706926 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706942..706960 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706945 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(707617..709308) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 708524..708605 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 709299 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(709353) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 709651 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709687..709706) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709705) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709721..709728) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(710153..710172) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(710167) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(710185..710191) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(710201..710761) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(710233) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(710744..710763) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710761) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710777..710786) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710849..710856 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 710865 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 710869..710888 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 711777 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 711856..711863 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711877..711896 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711885 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 712149..712156 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712172..712191 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712173 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 712797 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 712841 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 713787 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 713831 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(714405..714424) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714413) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(714438..714445) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 715635 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(715711) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716788..716807) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716814) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716822..716829) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716837..716843 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716858..716876 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716867 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 720079 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 720142..720147 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720163..720181 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 720184 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 720212..720215 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720232..720251 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720233..720538 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 720233 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 722457 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 722546..722555 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722565..722693 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 722565 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722569..722588 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(722619) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 725246..725255 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 725268..725287 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 725271 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 726116..726122 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726137..726156 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 726151 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 727383 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 727493 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(727534) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(728800..728819) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728818) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728835..728842) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(728911) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(729612..729631) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(729635) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(729703) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(731115..731134) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(731132) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(731149..731156) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 731234..731241 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 731249 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 731255..731273 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(732109..732128) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732123) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(732141..732150) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 733631 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 733715..733722 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 733736..733755 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 733741 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 735655 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 735735..735754 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 735743 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(735796) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(735880..735883) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735885) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735901..735902) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 736227 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736303..736310 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736324..736343 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736336 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 736623 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(738107) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(738633) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 739995..740001 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740016..740027 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740033 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(740215..740234) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740219) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740250..740254) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 740275..740278 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740294..740313 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740297 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 741451 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(742045) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(743075..743094) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743079) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(743081..743535) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(743107..743114) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 743173..743180 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743194..743213 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743201..744298 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 743201 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(744793..744812) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744800) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(744828..744835) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 744854..744861 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744873..745048 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 744873 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 744876..744895 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 745005 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(745457..747127) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 746556..747049 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 747037..747042 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747051..750316 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 747051 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747058..747076 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(748528..748547) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(748540) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(748562..748569) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(750010..750029) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(750031) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(750031) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 750286..750291 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750307..750325 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 750318..750943 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 750318 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 750939..750958 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 750945..751476 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 750945 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(751001..751020) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(751008) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(751034..751041) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(751437..751549) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(751538..751557) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(751549) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(751569..751576) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 751617..751623 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751637..751655 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751637 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(751681) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 752023 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 752068..752148 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 752149..752168 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 752150 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 753475 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 753533..753536 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753551..753570 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753559 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 755035 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 755134..755153 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 755145 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 758381 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 758504..758511 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758524..758543 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 758535..758607 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 758535 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 759906..759912 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759926..759937 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759927 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 760735 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 760814..760817 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760832..760851 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760845 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 761970..762301 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(762249..762268) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762263) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762283..762290) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(763022) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(763146..763276) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(763262..763280) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 763272..763277 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(763276) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 763287..764351 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 763288 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 763293..763311 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(763296..763301) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(763458..763563) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(763879..763959) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(764738..764757) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764751) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(764753..765889) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(764769..764777) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764820..764821 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764841..764860 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764844 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(765875..765894) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765889) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765908..765917) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 766125 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 766235 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(766289) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 767331..767337 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767353..767371 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 767357..768321 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 767357 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768222..768296) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(768273..768292) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768296) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768298..768820) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(768308..768312) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 768437 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 768438..768457 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(768818..768836) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768833) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(768852..768857) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768939..768945 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768960..768978 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768960 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(768996) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(769022..769122) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(769062) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 770411..773777 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(774449..774460) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774452) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774474..774480) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774509..774516 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774531..774550 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774538 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(774584) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(774610..774710) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(774650) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(776381..776396) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776388) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776409..776418) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 777733..777737 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777753..777772 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777756 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 778490 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 778572..778575 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778591..778610 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778600 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 779283 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(779358) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(783760..783779) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(783777) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(783794..783797) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 783904..783910 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783924..783942 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783927 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 784474 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(784518) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 784519..786169 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(785719..785810) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(785870) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(786058..786077) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786072) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786092..786093) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786139..786146 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786161..786180 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786171 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 787867..787873 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787888..787899 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787906..788062 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 787906 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(787938) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 788037 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(788092) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 788699..788705 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788721..788739 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 788725..789378 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 788725 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(789287..789306) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789302) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(789320..789327) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 789368..789373 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789380 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789388..789406 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 790499..790505 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790520..790531 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790524 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 791338 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(791391) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(793394..793413) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793412) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(793429..793433) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 793441..793448 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 793462..793481 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 793472 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 793662 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 793726..793732 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 793738 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 793747..793758 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 794573 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(794627) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(795493..795512) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(795507) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(795528..795531) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(795595) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(796542..796561) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(796545) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(796577..796580) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 796592..796596 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796610..796629 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796619 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 797514..797626 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 799039 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799333..799340 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799356..799375 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799362 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 799369..799652 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(799867..799886) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799885) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799901..799904) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 799920..800401 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 800372..800375 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800392..800411 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800403..800650 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 800403 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 801629..801721 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 801678 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 801762..801768 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801780..801799 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801789 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 803000 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 803172..803190 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 803179 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(805275) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 807861 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 807914..807921 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 807934..807953 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 807942 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 809801..809807 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 809819 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 809822..809833 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 810017 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(810083) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(810907..810999) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 811423..811428 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 811436 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 811443..811461 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 811447..812034 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(813959..813978) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813972) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813993..813996) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814203..814222 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814206 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 815625..815644 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 815627 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(815805..815819) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(815835..815841) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(815835) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 818003 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 818052..818059 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818074..818093 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818082 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 821633 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 821740..821747 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821761..821780 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821765 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 823079 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(823997) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(824045..824145) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(824085) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 827902 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 827972..827978 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827993..828012 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 828011 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 829905 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 832304..832309 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832324..832342 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832325 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(833348..833422) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(833391) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(833972..834051) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(834040..834059) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834051) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(834073..834078) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 834174..834177 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834193..834212 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 834200 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 834855 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 834991..834996 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835010..835029 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835020 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(835555..835943) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(835943) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(835945..835964) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(835977..835985) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(836207) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(836833..836852) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836845) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836866..836873) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(838059..838078) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838077) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838093..838100) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 838104..838123 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 838109 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(840260..840278) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840277) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840294..840297) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(840365) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(840856..840875) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840872) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840890..840896) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840917..840924 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840938..840957 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840946 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 843544 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(843602) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 844583..844590 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(844595..844614) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 844605..844624 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 844607..844698 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 844607 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(844612) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844629..844636) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 846709 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 846779..846781 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846797..846816 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846800 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 847735..847742 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847758..847777 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847767 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 848383 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(848453) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(848658) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(848661..848672) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(848687..848693) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(848832..848843) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(848834) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(848858..848864) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 849655..849658 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 849675..849694 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 849685..849857 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 849685 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(849791..849809) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(849805) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(849823..849829) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(850876..851144) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 850958 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 851042..851047 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851063..851082 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851068 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 852305..852539 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(852354) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852518..852525 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 852539..852558 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 852541..852613 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 852541 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(852548..852559) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852558) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(852574..852580) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 852872 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852961..852967 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852982 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852983..853001 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 853547..853614 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 853582..853591 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 853603..853618 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 853616 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 854808 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 854868..854874 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854888..854899 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 854896..854960 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 854896 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(854918..854937) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854927) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 854943..854949 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(854951..854952) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 854962..855042 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 854962 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 854964..854982 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(855192) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(855197..855201) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(855218..855222) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 856033..856103 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 858658 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(858716) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 859139..859148 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859161..859180 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859165 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(859666..859813) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 859770..859774 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859790..859809 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859797 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 859803..859880 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(859811..859830) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859813) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859845..859852) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 860827..860831 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860847..860866 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860859 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 860991..861303 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(861252..861263) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861254) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861277..861283) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 862073..862079 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862094..862105 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862095 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(862102..862116) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862123) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862125..862129) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 862377 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(862402) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 862475..862483 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862494..862512 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862496 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 862795 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 862851..862858 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862872..862891 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 862881..862955 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 862881 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 863477 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 865303 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(865404) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(866455..866545) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(866543..866562) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866552) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866577..866584) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(866677) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(867991..868010) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868010) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(868012..868723) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(868022..868027) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 868056..868063 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868077..868096 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868077 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 868626..868633 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868648..868667 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868654 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 869131 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 869197 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(869207) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 869533..869537 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 869545..869559 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(869549..869568) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 869549..869640 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 869549 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(869559) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 869617..869620 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 869635..869654 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 869642..869744 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 869642 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 870612..870619 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 870633..870652 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 870648..870920 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 870648 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(870681) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 875571..875656 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 875632..875639 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875653..875672 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875658 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 875974 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 877173..877249 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 877206 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 877251..877419 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 877376..877383 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 877382 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 877397..877416 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877421 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(877455..877472) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877458) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877493..877498) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(877528) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(877612) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(878401..878416) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(878423) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(878429..878438) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 878458..878464 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878479..878490 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878482 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 878702 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(878778) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(879035..879053) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879042) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879057..879064 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(879070..879075) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879077..879096 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 879085 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 879839..879843 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(879842..879861) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879854) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 879857..879876 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(879876..879883) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 879887 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 880018 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 881868 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 881913..882838 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(883313..883332) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(883330) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(883346..883355) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 883403..883409 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883424..883443 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883452 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(883770) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 885188..885194 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885209..885228 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885212 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885229..885248) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 885234..885563 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(885248) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885262..885269) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(885307..885325) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(885332) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 885520 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 889409..889428 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889415 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 890023..890093 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 890063..890070 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890084..890103 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890095 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 890206..890210 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890233..890249 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890249 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 890390 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(890457) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(891125..891144) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891139) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891157..891164) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891220..891225 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891239..891258 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891239 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 891364..891546 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(891469) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 891503 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 891548..892159 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(892101..892120) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(892122) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(892134..892141) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 893329 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 893346..893358 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 893351 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(893405) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 894306..894309 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 894324 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 894325..894344 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 894825 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 894912..894919 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894934..894953 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894935 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 896915 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 896959 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 897025 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(897058..897233) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(897101) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(897225..897244) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897233) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897259..897266) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 897298..897303 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897319..897337 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897319 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 897823..897923 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 897883 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 897949 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 899269 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 899333..899338 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899354..899372 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 899357..899455 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 899357 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 899654..899657 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899672..899691 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899676 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(899917) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 900613 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 900721..900728 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 900743..900762 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 900743 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 901083..901089 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901104..901122 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901117 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 901267..901273 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901287..901298 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901293 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 904527 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 904628..904634 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904649..904668 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904659 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(905011..905029) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905025) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(905045..905050) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 908377 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(908501) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(908691..908818) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 908778..908789 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 908795 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(908807..908826) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908818) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(908820..909958) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(908840..908845) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908985..908992 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909007..909025 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909014 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 909015..909125 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 909915 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(911048..911067) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(911069) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(911083..911087) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 911145..911152 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911166..911185 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911172 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(912238..912641) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 912581 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(913112..913130) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913140) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913145..913151) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913189..913195 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913209..913220 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913213 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 913443..913449 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 913460 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 913463..913474 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 913791 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 913859..913868 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913882..913901 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913892 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 914781 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(914854) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915521..915532) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915523) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915547..915553) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 915562..915570 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 915581..915599 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915596 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 919798 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 920813..920821 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920814..920825) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(920820) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920822..921308) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 920832 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 920835..920854 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(920839..920845) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(921294..921313) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(921308) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921348..921354 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 921363 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 921368..921379 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(921378..921392) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921392) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921400..921404) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(921726..921826) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(921766) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 921800 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(921832) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 921872..921879 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921893..921912 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921901 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 924151 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 924474..924481 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 924496..924515 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 924507..924588 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 924507 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 926542..926549 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926564..926583 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926575 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 926590 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 926635..926725 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 928370..928376 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 928391..928410 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 928401 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 929060..929148 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 929105 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 929111..929211 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 929171 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 930629..930634 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 930649..930667 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 930658 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 930712..930718 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930733 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930734..930752 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 930835 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 930880..930953 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 930935..930942 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930955 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930956..930975 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 932733 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 932778..932847 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 932849..932868 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 932849 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 935159 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(935230) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(935487..935498) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935498) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(935512..935519) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 935586..935592 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935606..935617 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935616 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 935976..937842 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(936029) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(936116) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(937523..937541) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937535) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(937555..937562) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(937666) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 938064..938070 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938084..938095 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938086..938196 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 938086 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(938098..938117) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938114) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938129..938135) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 938155 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(938188) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(939732..939750) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(939752) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(939764..939770) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 939813..939818 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939834..939852 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939847 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 941258 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(941334) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(942720) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(942722..944253) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(942730..942741) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 942849..942856 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942869..942888 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942875..943162 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 942875 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 943125..943128 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943143..943162 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943164 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 944089 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 944219 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(944253) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(944260..944275) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 944265 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(944287..944296) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 945226..945227 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(945239..945258) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 945244..945263 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945245) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 945254 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945273..945278) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 946393..946399 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946414..946432 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 946419 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 947333 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 947410..947413 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 947425 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947428..947447 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 947473..947492 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 947478..947574 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 947478 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 948952 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 949033..949037 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 949053..949072 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 949060 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 950426 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 951938..951941 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951956..951975 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951958 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(951960..951979) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951972) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951995..951999) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 952406 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(952482) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(954294..954396) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(954385..954404) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954396) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954418..954421) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954434..954440 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 954451 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 954455..954473 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(954484) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 955464 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 955547..955550 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955565..955584 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955570 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 956234 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 956279..958233 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(956307) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(958126..958145) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958136) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958160..958166) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(958162..958262) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 958197..958204 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(958202) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958218..958237 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 958235 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 959437 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 959482..959620 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 959616..959635 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 959622..959778 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 959622 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 961054 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 961140 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(962669..962688) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(962690) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 962737..962745 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962754 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962759..962774 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 962768..962841 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 962828..962829 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962843 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962845..962864 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 962986..963039 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 963010 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 963090..963109 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 963096 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 964229 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 964286..964305 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 964286 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 965034 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(965110) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965930..965935 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(965935..966034) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 965951..965969 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965953 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 965958..966153 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(966023..966042) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966037) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(966057..966060) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 966152..966171 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 966155..966218 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 966155 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 967058 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(967134) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(968472..968542) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(968515..968534) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(968542) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(968630) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(969120..969138) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(969140) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(969153..969159) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 969177..969184 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 969192..969261 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 969193 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 969199..969218 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 969353 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 969424..969542 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 973306 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(973382) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 973972..974072 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(974001..974020) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974016) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 974032 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974035..974038) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(974165..974184) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974174) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974198..974207) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 974230 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(974261) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(974460..974570) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 974500..974600 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 974560 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(974576) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974580..974591) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(974606..974612) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(974702) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(974927..974946) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974944) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974960..974967) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(975054) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(975098) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(976802..976816) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(976814) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(976830..976838) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977479..977584) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(977568..977586) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977588) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977602..977607) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977650..977657 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977672..977691 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977683 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 978879..978970 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 979312 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(979475) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(980463..980482) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980475) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980496..980503) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 980578..980585 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 980598 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 980600..980619 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 980609..980762 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 980719 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 980764..980847 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 980804 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 980860..980865 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980881..980899 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980890 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 981775 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 981838..981841 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 981856..981875 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 981864 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 983380 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(983434) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(985563..985582) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(985587) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985596..985603) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985623..985630 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985645..985664 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985655 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 986484 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(986725..986743) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986736) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986754..986762) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986763..986766 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986781..986800 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986791 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 988948 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 989012..989019 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989031..989050 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989036 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(989772) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 991583..991588 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991604..991622 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991610 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 993201..993206 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993221..993240 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993236 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 994189 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 994270..994275 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994291..994309 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994294 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 994541 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(994579) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(994777) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(995505..995524) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995529) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995538..995545) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995565..995574 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 995586 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 995587..995606 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(995623..995637) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995624) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(995646..995650) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 995714..995965 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 995922 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(995934..996196) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 995967..996450 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(995977) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996189..996208) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996196) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(996198..996266) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(996222..996227) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 996572..996580 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996592..996610 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996605 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(996816..996835) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996834) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996851..996857) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 996934..996937 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996952..996971 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996957 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(997188..997330) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(997231) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 997335..998100 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(997407) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 997938..997942 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997950..997963 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997962 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(997967..997986) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(997990) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(998001..998004) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 998057 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(998124) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 998553..998558 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(998559..998578) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(998573) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 998574..998592 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998574 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998575..998838) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 998798..1000233 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(998883) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(999390..999477) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(999469..999488) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999477) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999502..999509) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1000632..1000651) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1000643) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000645..1000726) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1000771) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1001210..1001229) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001224) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1001227 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1001243..1001250) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1001249..1001545) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1001292) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1001543..1001554) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001549) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1001569..1001575) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1001605..1001612 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001626..1001645 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001635 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1002960..1002978) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002975) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002994..1002999) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1004321 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1004385) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1004450) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005589..1005608) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005610) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005622..1005627) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1007040..1007059) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007045) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007072..1007081) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1007481) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1007967..1007986) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1007969..1007973 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1007988) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1007989..1008008 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007990 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008003..1008004) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008021..1008027 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008042..1008053 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008047 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1008120..1008131) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1008123) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008145..1008151) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010257..1010263 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010277..1010296 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1010287 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1012425 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1013811 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1013895..1013902 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013916..1013935 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013921 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1014299..1014302 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1014317 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1014319..1014338 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1014556..1014625 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1016935 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1017008) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017986..1018005) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1018004) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1018019..1018025) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1018031..1018039 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018050..1018068 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018057 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1018591..1019212) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1018876..1019247 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1019190..1019209) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019211) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019223..1019232) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019225..1019232 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019247..1019266 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019249 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1020719 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1020815) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1022075..1022175) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1022174..1022193) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022175) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1022177..1022313) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1022208..1022214) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1022358) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1022504..1022523) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022523) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022536..1022543) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022567..1022573 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022587..1022606 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022590 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1025076 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1025116..1025119 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1025134..1025153 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1025141 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1026726 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1026802) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1027200..1027211) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027204) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027226..1027232) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1027265..1027268 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1027276 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1027283..1027302 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1027756..1027775) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027770) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027791..1027796) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1028596 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1028646) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1029794..1029860) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1029849..1029868) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1029866) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1029884..1029888) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030173..1030180 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1030195..1030214 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1030197 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1030693..1030700 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1030715..1030734 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1030722 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1031742 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1031787..1031897 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1031875..1031882 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031898..1031917 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031899 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1032908 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1032984) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1033566..1033585) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033578) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033601..1033604) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1036160..1036179) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1036174) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1036735..1036754) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1036749) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1036769..1036776) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1036856) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1038197..1038215) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038200) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1038229..1038235) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1039838..1039856) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1039848) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1039867..1039872 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1039871..1039876) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039884 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039888..1039906 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1040762 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1040841) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1041058..1041077) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1041061..1041062 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1041061 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1041065..1041080 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041080) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1041082..1041937) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1041092..1041099) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1041264..1041271 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1041283..1041302 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1041289 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1041913..1042058 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1041982) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1042045..1042048 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1042060 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1042066..1042070 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1042104 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1042149..1043015 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1042885..1042903) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1042902) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1042918..1042924) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1042992..1042999 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043014..1043033 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043017 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1043336 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1043384) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1045054..1045172) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1045155..1045174) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045172) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045187..1045194) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1045260) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1045461..1045466 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1045482..1045500 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1045483 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1045492..1045731 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1045653..1045672) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045671) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045687..1045694) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045713..1045720 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045733 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045734..1045753 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1046899 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1046957..1046964 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046978..1046997 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1046987..1047086 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1046987 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1048594..1048601 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048613 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048615..1048634 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1049152 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1049204..>1049224) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1049224,1049240) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1049225..1049239 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1049240..1049526 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1049240..1049361) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1049246) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1050517..1050588) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1050571..1050590) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1050587) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1050604..1050609) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1051849..1051868 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1051854 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1053255..1053262 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053277..1053296 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053284 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1054152) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1054611..1054630) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054631) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054643..1054652) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054700..1054707 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054721..1054740 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054733 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1061950..1062020 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1065840..1065846 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065861..1065872 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065868 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1065937..1066910) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1066881 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1066955) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1066959..1066960 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1066979 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1067018..1067605) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1067018..1067605) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1067620..1067639) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1067639) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1067655..1067657) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1067660..1067666 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067678 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067681..1067699 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1067684..1067750 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1067751..1069595 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1067751..1069595 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1069596..1069663 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1069620 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1069725..1070204) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1069725..1070204) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1070224) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1070228..1070246) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1070257..1070265) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1070396..1070400 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1070413 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1070415..1070434 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1070436..1071260 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1070436..1071260 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1070648..1070654 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070669..1070687 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070676 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1071270..1072720 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1071290..1072657) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1071290..1072657) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1072689..1072696 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072710..1072729 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072722 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1072781..1073644 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1072781..1073644 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1073662..1074675 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1073662..1074675 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1074658 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1074727..1074734 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1074749..1074768 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1074768..1074883 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1074768 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1074884..1075912 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1074884..1075912 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1075934 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075963..1076472) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1075963..1076472) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1075982) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1076485..1076503) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076501) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1076515..1076523) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1076522..1077184) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1076522..1077184) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1077203..1077209 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077223..1077242 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077232 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1077251..1078705 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1077251..1078705 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1078560..1078712) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1078595) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1078713..1079351) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1078713..1079351) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1079352..1079486) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1079400..1079405 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1079421..1079439 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1079422 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1079432..1079556 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1079472..1079491) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079486) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079506..1079513) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079557..1080363 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1079557..1080363 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1080356 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1080391..1080990) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1080391..1080990) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1080410) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1080987..1082156) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1080987..1082156) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1082157..1082268) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1082269..1082979) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1082269..1082979) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1083023..1083042) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1083045) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1083055..1083064) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1083094..1083103 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1083117..1083136 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1083128 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1083164..1083850 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1083164..1083850 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1083847..1084605 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1083847..1084605 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1084602 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1084650..1085279) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1084650..1085279) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1085313..1085331) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085330) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085346..1085351) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1085375..1086490) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1085375..1086490) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1085404) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1086499..1087767) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1086499..1087767) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1087793..1087804) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087802) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087818..1087824) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1087879..1088727) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1087879..1088727) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1087890) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1088732..1089181) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1088732..1089181) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1089202..1089221) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1089216) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1089237..1089238) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1089271..1091109) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1089271..1091109) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1089298) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1091191) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1091199..1091316) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1091199..1091316) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1091368..1091387) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1091382) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1091402..1091409) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1091423..1091914) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1091423..1091914) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1091932..1091935 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1091938..1091957) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1091950..1091969 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091951 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1091956) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1091972..1091979) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1092013..1092909 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1092013..1092909 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1092896 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1092962..1093546) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1092962..1093546) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1092972) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1093543..1094472) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1093543..1094472) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1093630) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1094457..1094993) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1094457..1094993) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1095029..1095048) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095043) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095063..1095066) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1095134..1095141 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1095156..1095175 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1095159 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1095171..1095518 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1095171..1095518 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1095515..1096102 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1095515..1096102 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1096122..1096415 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1096122..1096415 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1096395 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1096439 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1096551..1098167 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1096551..1098167 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1098155 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1098214..1099065) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1098214..1099065) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1098231) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1098612..1098619 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098634..1098653 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1098639..1099164 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1098641 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1099106..1099125) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1099129) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1099143..1099148 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099163..1099181 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099166 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1099203..1100045 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1099203..1100045 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1099698..1099706 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099717..1099735 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099717 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1100046..1100159 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1100160..1100519 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1100160..1100519 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1100508 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1100550..1100747) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1100550..1100747) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1100563) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1100748..1100944) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1100944) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100946..1100957) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1100972..1100978) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1101004..1101816) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1101004..1101816) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1101854..1101873) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1101874..1101881 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1101874) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1101887..1101894) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1101893..1101912 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1101895 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1101937..1102704 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1101937..1102704 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1102713..1102719 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1102733 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1102734..1102753 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1102768..1103076 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1102768..1103076 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1103061 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1103106..1103371 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1103372..1104802 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1103372..1104802 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1104847..1105341 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1104847..1105341 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1105305 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1105479..1105486 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1105485 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1105500..1105519 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1105548..1106585 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1105548..1106585 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1106605..1107825 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1106605..1107825 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1107840..1108616 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1107840..1108616 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1108613..1109770 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1108613..1109770 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1109841..1110896 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1109841..1110896 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1110451,1110452) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1110730..1110749) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1110740) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1110889..1113981 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1110889..1113981 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1113969..1114928 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1113969..1114928 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1114891 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1114931..1115205) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1114956..1114962 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1114964) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1114977..1114988 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1114998 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1115014..1115193 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1115014..1115193 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1115203 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1115239..1115424) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1115239..1115424) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1115250) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1115453..1115472) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115470) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115483..1115490) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1115525..1115531 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1115543..1115562 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1115548 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1115605..1115614 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1115614 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1115627..1115646 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1115673..1116407 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1115673..1116407 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1116166..1116768) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1116388..1116393 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1116406 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1116406 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1116409..1116427 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1116489..1117046 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1116489..1117046 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1116748..1116767) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1116768) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1116782..1116786) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1117053..1117060 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1117075..1117094 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1117087 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1117137..1118090 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1117137..1118090 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1117754..1117758 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1117774..1117793 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1117787 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1118105..1118296 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1118105..1118296 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1118275 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1118320..1118660 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1118326..1118565) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1118326..1118565) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1118342) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1118578..1118597) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118599) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118611..1118620) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1118626..1118633 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118648..1118667 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118662 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1118730..1119668 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1118730..1119668 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1118807..1118816 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1118825 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1118828..1118843 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1119691..1120932 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1119691..1120932 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1119905..1119923) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1119913) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1119939..1119944) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1120783 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1120916 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1120957..1120966 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1120979..1120998 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1120981 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1120993..1121001 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1121008..1121793 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1121008..1121793 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1121013..1121031 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1121025 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1121794..1121878 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1121810..1121828) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1121827) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1121843..1121848) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1121846..1121853 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1121868..1121887 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1121880..1121984 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1121880 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1121985..1122971 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1121985..1122971 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1122968..1123957 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1122968..1123957 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1123963..1123969 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1123968..1124044 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1123968 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1124045..1124536 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1124045..1124536 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1124509..1125675 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1124509..1125675 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1125666 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1125751..1126701 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1125751..1126701 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1126718..1127629 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1126718..1127629 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1127643 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1127688..1127795 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1127768..1127773 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1127789..1127807 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1127797 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1127834..1128586 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1127834..1128586 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1128566 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1128621..1129613) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1128621..1129613) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1128642) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1129672..1129886) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1129672..1129886) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1129720) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1129905..1129924) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1129918) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1130173..1130180 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1130194..1130356 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1130195..1130214 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1130195 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1130357..1131994 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1130357..1131994 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1131888 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1131995..1132101 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1132102..1133037 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1132102..1133037 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1132145..1132164) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132162) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1132180..1132186) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1133041..1133958 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1133041..1133958 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1133963..1135039 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1133963..1135039 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1135041..1135958 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1135041..1135958 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1135928 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1136008..1136011 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1136024 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1136026..1136045 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1136065..1137282 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1136065..1137282 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1137335..1137344 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1137357..1137372 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1137366..1137445 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1137366 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1137446..1138024 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1137446..1138024 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1138025..1138139 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1138076..1138095) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138080) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138109..1138116) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1138142..1138155 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1138142 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1138205..1138600 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1138205..1138600 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1138436..1138536) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1138476) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1138598 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1138643..1139432 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1138643..1139299) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1138643..1139299) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1139329..1139347) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139344) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1139362..1139367) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1139405..1139412 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1139426..1139445 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1139434..1139575 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1139434 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1139469..1139609 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1139469..1139609 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1139576..1140232 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1139576..1140232 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1140222 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1140227..1140349) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1140227..1140349) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1140267..1140356 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1140335..1140343 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140354..1140372 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1140358..1140422 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1140358 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1140423..1141544 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1140423..1141544 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1141198..1141204 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1141216 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1141219..1141237 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1141430..1141438 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1141450..1141468 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1141457 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1141538..1141544 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141559..1141570 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141568 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1141591..1143603 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1141591..1143603 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1141666..1141673 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1141688..1141707 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1141700 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1143550 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1143604..1143905 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1143641..1143808) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1143641..1143808) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1143654) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1143828..1143846) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1143844) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1143862..1143867) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1143898..1143905 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1143907..1144032 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1143907 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1143913..1144051 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1143913..1144051 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1143920..1143939 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1143989 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1144122..1145021) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1144122..1145021) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1144153) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1144357..1144362 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144369 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144378..1144396 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1144385..1146286 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1145018..1145416) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1145018..1145416) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1145417..1145596) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1145588..1145607) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145596) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1145619..1145626) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1145671..1146216) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1145671..1146216) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1145695) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1146217..1146419) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1146420..1146992) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1146420..1146992) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1146565..1146583) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1146574) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1146596..1146603) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1147021..1147040) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1147038) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1147054..1147057 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1147055..1147062) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1147070 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1147073..1147092 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1147117..1147485 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1147117..1147485 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1147514..1148149 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1147514..1148149 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1148168..1148968 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1148168..1148968 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1149031..1149882 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1149031..1149882 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1149841 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1149895..1150629) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1149895..1150629) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1149917) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1150751..1150755 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1150772..1150791 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1150786 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1150787..1150863 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1150864..1152708 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1150864..1152708 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1151191..1151210) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1151215) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1152710..1152717 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1152731..1152750 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1152737 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1152770..1152878 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1152770..1152878 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1152873 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1152957..1153667 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1152957..1153667 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1153642..1154259 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1153642..1154259 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1154243..1155352 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1154243..1155352 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1155352..1155552 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1155352..1155552 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1155549..1156319 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1155549..1156319 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1156316..1157326 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1156316..1157326 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1157345..1158160 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1157345..1158160 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1158134 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1158207..1158213 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1158226..1158245 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1158236 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1158296..1159072 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1158296..1159072 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1159061 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1159076..1159077 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1159077..1160137 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1159081..1161360) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1159081..1161360) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1159099) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1161235..1161409) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1161288..1161296 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161307..1161325 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1161311..1161446 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1161311 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1161397..1161416) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1161408) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1161424..1161430 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1161432..1161436) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161445..1161463 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161448 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1161477..1161731 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1161477..1161731 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1161707 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1161797) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1161804..1162226) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1161804..1162226) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1162230..1162745) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1162230..1162745) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1162782..1163504) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1162782..1163504) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1163543..1163562) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1163564) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1163613..1163620 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1163635..1163654 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163639 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1163672..1163792 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1163672..1163792 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1163797 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1163860..1164981 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1163860..1164981 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1164974..1166146 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1164974..1166146 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1166129 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1166163..1166181 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1166173 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1166174..1167703 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1166179..1166724) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1166179..1166724) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1166200) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1166794..1167984) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1166794..1167984) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1168010..1168029) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168014) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1168044..1168051) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1168078..1168085 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1168089 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1168099..1168118 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1168157..1168229 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1168157..1168229 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1168171..1168188) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168185) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1168209..1168215) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1168219 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1168244..1168979) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1168264..1169912 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1168273) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1168981..1169069) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1169024) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1169070..1170299) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1169070..1170299) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1169192) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1169869 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1170300..1170385) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1170340..1170347 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170362..1170381 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1170371..1170390) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170375 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1170389) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1170403..1170409) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1170425..1170745 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1170425..1170745 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1170755 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1170800..1170897 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1170898..1171029 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1170898..1171029 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1171045..1171218 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1171045..1171218 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1171255..1171716 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1171255..1171716 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1171687..1171694 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1171709..1171728 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1171717..1171957 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1171717 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1171930..1171937 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171951..1171969 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171959 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1171982..1172485 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1171982..1172485 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1172497..1172781 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1172497..1172781 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1172751 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1172783) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1172794..1172797) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1172942..1173469 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1172942..1173469 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1173616..1173621 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1173634..1173653 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1173637 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1173643..1173960 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1173643..1173960 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1173961..1174196 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1174197..1174952 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1174197..1174952 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1174953..1175040 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1174997 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1175040..1175100) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1175071) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1175101..1175448) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1175101..1175448) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1175480..1175498) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1175493) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1175495..1175951) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1175509..1175517) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1175911..1175929 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1175923 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1175929..1175948) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1175951) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1175962..1175969) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1175999..1177945 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1175999..1177945 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1177921 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1177975..1177976 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1177976..1178074 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1178049..1178055 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178070..1178089 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178076..1178144 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1178076 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1178145..1178627 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1178145..1178627 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1178607 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1178673..1179179) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1178673..1179179) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1178697) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1179204..1179223) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1179210) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1179212..1179397) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1179398..1179793) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1179398..1179793) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1179816..1179834) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1179829) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1179831..1180531) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1179849..1179854) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1179937..1179944 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1179958..1179977 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1179969 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1180022..1180501 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1180022..1180501 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1180500 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1180541..1180735) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1180541..1180735) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1180576) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1180749..1180764) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1180765) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1180776..1180785) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1180901..1181230) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1180901..1181230) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1181267..1181286) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181280) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1181282..1181849) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1181301..1181306) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1181334..1181338 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181354..1181373 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1181358..1181859 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1181358 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1181850..1182839) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1181850..1182839) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1182840..1182859) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1182843) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1182873..1182878) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1182962..1183210) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1182962..1183210) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1182972) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1183206..1183210 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1183219..1183233 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1183228 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1183235..1183254) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1183244) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1183268..1183277) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1183325..1183332 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1183339..1183358) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1183346..1183365 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1183348) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1183359 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1183360..1183463 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1183372..1183379) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1183464..1184867 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1183464..1184867 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1184856 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1184907..1185380) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1184907..1185380) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1184911) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1185402..1185420) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1185420) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1185435..1185440) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1185505..1185672) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1185505..1185672) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1185508) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1185684..1185702) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1185693) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1185715..1185722) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1185799..1186698 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1185799..1186698 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1186707..1187105) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1186707..1187105) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1186737) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1187134..1187153) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187153) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187168..1187175) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1187206..1187781) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1187206..1187781) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1187221) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1187800..1187818) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187815) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187832..1187838) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1187856..1187862 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1187877..1187895 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1187878 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1187927..1190884 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1187927..1190884 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1190877..1191437 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1190877..1191437 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1191430 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1191475..1191593 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1191571..1191574 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191590..1191609 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1191595 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1191634..1192275 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1191634..1192275 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1191643) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1192248 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1192354..1192980 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1192354..1192980 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1192982 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1192985) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1193011..1193289) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1193011..1193289) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1193029) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1193318..1193329) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1193331..1193337) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1193337) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1193339..1193755) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1193507 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1193508..1193527 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1193525..1193679 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1193680..1194870 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1193680..1194870 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1193753..1193772) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193755) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1193786..1193795) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1194893..1196071 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1194893..1196071 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1196112..1196300) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1196112..1196300) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1196128) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1196326..1196345) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196329) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196359..1196365) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1196387..1196394 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1196409..1196428 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1196420 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1196435..1196454) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196439) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196469..1196476) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1196474..1197286 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1196474..1197286 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1197265 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1197332..1198084) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1197332..1198084) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1197341) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1198084..1198836) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1198084..1198836) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1198956..1199930) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1198956..1199930) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1198991) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1199951..1199970) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1199977) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1199979..1202485) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1199985..1199992) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1200013..1200019 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200034..1200052 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200037 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1200062..1200559 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1200062..1200559 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1200560..1200673 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1200653..1200657 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200673..1200692 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1200675..1200947 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1200675 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1200948..1201370 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1200948..1201370 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1201410..1202588 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1201410..1202588 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1202419..1202519 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1202477..1202495) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202479 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1202485) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202507..1202515) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1202587 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1202696..1202703 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202718..1202737 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202743 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1202786..1204207 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1202786..1204207 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1204275..1205654 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1204275..1205654 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1204794..1204813) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1204799) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1204827..1204834) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1205679 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1205689..1205696 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1205691..1205758 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1205759..1206772 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1205759..1206772 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1206778..1207797 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1206778..1207797 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1207822..1208901 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1207822..1208901 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1208898..1209734 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1208898..1209734 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1209782..1211050 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1209782..1211050 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1210994..1210997 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211013..1211017 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211015 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1211083..1211102 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1211083 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1211138..1212139 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1211138..1212139 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1211821..1211921) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1211861) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1212115 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1212216..1213658 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1212216..1213658 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1213655..1215148 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1213655..1215148 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1215187..1215951) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1215187..1215951) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1215206) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1215719,1215721) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1215978,1215985) /created_by="User" /modified_by="User" /label="TF8A" N_region 1215979..1215984 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1215987..1216307 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1215987..1216307 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1216316 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1216325..1216528) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1216344..1216481) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1216344..1216481) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1216368) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1216567..1216737) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1216567..1216737) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1216573) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1216737..1217483) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1216737..1217483) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1217318..1217337) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217335) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217353..1217360) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1217509..1217527) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217522) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217543..1217548) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1217593..1218594) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1217593..1218594) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1217622) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1218607..1219224) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1218607..1219224) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1219260..1219279) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219262) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1219264..1219361) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1219295..1219299) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1219341..1219360) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219361) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1219375..1219382) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1219406..1219425) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1219418) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1219500..1220816) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1219500..1220816) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1219515) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1220863..1220882) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1220879) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1220897..1220900) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1221099..1221106 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1221121..1221140 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1221133..1221204 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1221133 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1221205..1222155 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1221205..1222155 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1222143 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1222256..1222402 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1222256..1222402 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1222410..1224560 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1222410..1224560 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1223299..1223399 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1223359 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1223447 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1224572..1225543 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1224572..1225543 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1224900..1225541) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1225586) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1225611..1225977) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1225654) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1225957..1225972) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225977) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1225984..1225993) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1226061..1227410) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1226061..1227410) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1226075) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1227450..1227457 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1227462..1227481) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227470 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1227472..1227491 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1227480) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1227482..1227564) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1227492..1227499) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227521..1227527 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227542..1227561 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227545 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1227547..1227566) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227564) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1227579..1228397 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1227579..1228397 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1227582..1227585) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1228375 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1228454..1228461 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228476..1228495 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1228480 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1228526..1229350 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1228526..1229350 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1229367..1230293 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1229367..1230293 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1230299..1231261 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1230299..1231261 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1230993..1230998 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1231014..1231032 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1231015 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1231266..1232273 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1231266..1232273 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1232276..1233925 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1232276..1233925 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1233919 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1234013..1234972 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1234013..1234972 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1234969..1236069 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1234969..1236069 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1236066..1236956 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1236066..1236956 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1236969..1237958 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1236969..1237958 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1237252..1237979) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1237948 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1237993..1239161 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1238001..1239050) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1238001..1239050) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1238024) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1239077..1239096) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1239088) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1239111..1239118) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1239140..1240000) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1239140..1240000) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1240025..1240043) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240042) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240059..1240065) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240074..1240081 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240095..1240114 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240102 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1240160..1240678 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1240160..1240678 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1240669 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1240743..1240749 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1240761..1240867 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1240761 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1240763..1240774 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1240842..1240845 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240861..1240880 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240869 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1240917..1242116 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1240917..1242116 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1242105 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1242150..1242521 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1242193..1242417) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1242193..1242417) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1242497..1242503 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1242517..1242528 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1242523 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1242562..1243293 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1242562..1243293 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1243271 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1243332..1243340 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1243351..1243369 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1243359 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1243385..1243912 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1243385..1243912 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1243902..1244420 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1243902..1244420 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1244414..1244421 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1244435..1244454 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1244438 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1244453..1244564 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1244453..1244564 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1244527 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1244642..1244980 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1244642..1244980 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1244980..1245297 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1244980..1245297 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1245297..1245300 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1245316..1245335 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1245328 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1245368..1246270 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1245368..1246270 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1246261 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1246317..1246323 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1246329 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1246337..1246356 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1246358..1246568 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1246358..1246568 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1246526 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1246621..1247718 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1246621..1247718 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1246808..1246810 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246812..1246816 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246812 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1247730..1248977 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1247730..1248977 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1248968 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1249039..1249046 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249061..1249080 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249070 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1249103..1249528 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1249103..1249528 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1249517 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1249559..1250002) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1249559..1250002) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1249593) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1250029..1250048) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250035) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1250063..1250066) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1250084..1250090 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250104..1250122 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250110 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1250145..1250555 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1250145..1250555 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1250533 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1250582..1250752 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1250582..1250752 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1250753..1251430 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1250802..1251272) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1250802..1251272) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1250826) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1251294..1251313) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1251310) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1251312..1251419) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1251329..1251332) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1251388 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1251445..1253733) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1251445..1253733) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1251464) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1253734..1253796) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1253756..1253856) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1253796) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1253861..1254016) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1253861..1254016) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1253862) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1254049..1254068) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1254061) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1254063..1254148) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1254084..1254091) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1254149..1255108) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1254149..1255108) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1255109..1255160) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1255153..1255172) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1255165) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1255186..1255192) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1255277..1255280 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1255293 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1255296..1255315 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1255331..1256164 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1255331..1256164 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1256140 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1256195..1256959) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1256195..1256959) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1256216) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1256934..1258577) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1256934..1258577) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1258564..1259163) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1258564..1259163) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1259165..1259767) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1259165..1259767) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1259845) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1259864..1259976) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1259864..1259976) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1259977..1259980 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1259991..1260010) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1259996..1260015 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1260007 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1260012) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1260025..1260032) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1260078..1260764 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1260078..1260764 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1260768..1262132 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1260768..1262132 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1262129..1262809 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1262129..1262809 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1262838..1262843 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262859..1262877 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262862 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1262901..1263413 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1262901..1263413 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1263399 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1263444..1263450 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1263464..1263475 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263465 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1263496..1263633 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1263496..1263633 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1263606 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1263692..1263699 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1263713..1263732 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1263715..1264034 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1263715 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1263747..1263900 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1263747..1263900 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1264012..1264021 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1264034..1264053 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1264036..1264137 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1264036 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1264138..1265493 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1264138..1265493 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1265484 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1265536..1265868) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1265536..1265868) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1265884..1265903) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265894) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1265896..1266284) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1265919..1265924) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1265956..1266056 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1266016 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1266063..1266218 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1266063..1266218 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1266227..1266234 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1266241..1266258 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1266258 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1266269..1266288) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1266284) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1266302..1266308) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1266306..1266488 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1266306..1266488 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1266456 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1266513..1266521 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1266532..1266550 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1266538..1266620 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1266538 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1266621..1267085 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1266621..1267085 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1267070 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1267100..1268221) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1267100..1268221) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1267509..1267517 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267531..1267550 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1267534..1268312 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1267534 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1268250..1268261) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268270) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268276..1268282) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1268313..1268864 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1268313..1268864 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1268832 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1268892..1269704) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1268892..1269704) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1269664..1269683) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1269678) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1269697..1269702) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1269805..1269811 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1269822..1269896 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1269822 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1269825..1269836 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1269897..1271591 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1269897..1271591 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1271604..1272617 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1271604..1272617 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1272602 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1272643..1274478) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1272643..1274478) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1272692) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1274482..1275417) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1274482..1275417) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1275388..1275399) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1275398) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1275414..1275420) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1275454..1277856) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1275454..1277856) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1275486) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1277704..1277906) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1277895..1277913) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1277906) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1277927..1277934) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1277973..1277980 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1277994..1278013 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278006 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1278037..1278702 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1278037..1278702 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1278571..1278590) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278588) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1278604..1278613) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1278697..1278704 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278719..1278738 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278732 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1278758..1278891 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1278758..1278891 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1278779..1279753 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1278779..1279753 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1278842 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1279741 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1279863..1279871 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1279885..1279893 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1279895 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1279898..1279984 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1279957..1279964 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1279978..1279997 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1279986 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1280017..1280772 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1280017..1280772 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1280769..1281914 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1280769..1281914 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1281915..1283074 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1281925..1282119) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1281925..1282119) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1281932) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1282162..1282173) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282172) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1282188..1282194) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1282250..1282951) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1282250..1282951) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1282284) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1282952..1283032) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1283024..1283043) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283032) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1283048..1283055 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1283057..1283064) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1283069..1283088 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1283076 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1283122..1284018 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1283122..1284018 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1284012 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1284123..1284127 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284143..1284162 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284147 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1284192..1285541 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1284192..1285541 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1285529 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1285590..1285596 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285610..1285621 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1285618..1285685 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1285618 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1285686..1285841 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1285686..1285841 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1285844..1286020 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1285844..1286020 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1285910..1286010 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1285970 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1286016 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1286063..1287085) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1286063..1287085) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1286086) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1287130..1287149) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287146) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287161..1287167) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1287274..1287282 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1287290 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1287293..1287311 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1287338..1289554 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1287338..1289554 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1289329..1290269) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1289407..1289414 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289429..1289448 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289431 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1289551..1290048 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1289551..1290048 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1290049..1290288 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1290138..1290263 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1290138..1290263 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1290256 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1290297..1291358) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1290297..1291358) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1290314) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1291366..1292559) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1291366..1292559) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1291426 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1292646) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1292652..1292808) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1292652..1292808) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1292843..1292862) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1292844) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1292878..1292885) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1292888..1292891 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1292892..1293671) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1292892..1293671) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1292907..1292926 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1292916 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1293364..1293371 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1293384..1293403 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1293399 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1293406..1293723 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1293693..1293700 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1293701..1293720) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1293715..1293734 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293715) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1293725 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1293736..1293743) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1293766..1294962 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1293766..1294962 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1294944..1294951 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294966..1294985 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294985 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1295001..1295101 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1295001..1295101 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1295100 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1295186..1296403 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1295186..1296403 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1296400..1297107 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1296400..1297107 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1297065..1297694 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1297065..1297694 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1297709..1298245 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1297709..1298245 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1298092..1298285) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1298245 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1298286..1298606) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1298286..1298606) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1298344) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1298607..1298696) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1298632..1298638 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1298653..1298671 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1298663 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1298664..1298748 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1298678..1298697) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298695) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1298712..1298715) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1298722..1298729 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1298744..1298763 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1298750..1298808 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1298750 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1298806) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1298809..1299066 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1298809..1299066 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1299060 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1299152..1299583 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1299152..1299583 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1299611..1301131) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1299611..1301131) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1299623) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1300332..1300338 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300352..1300363 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300358 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1301139..1301158) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1301160) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1301258..1301265 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1301280..1301299 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1301282 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1301324..1301761 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1301324..1301761 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1301744 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1301801..1302586) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1301801..1302586) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1301820) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1302282) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1302558..1303370) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1302558..1303370) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1303401..1303419) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303417) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303433..1303440) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1303508..1303730) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1303540) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1303753..1305852) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1303753..1305852) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1303775) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1305853..1306103) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1306063..1306163) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1306103) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1306139..1306144 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1306154 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1306160..1306178 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1306217..1307260 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1306217..1307260 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1307261..1307352 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1307329..1307333 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307350..1307369 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307354 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1307399..1307443 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1307399..1307443 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1307420 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1307465..1307572 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1307573..1308232 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1307573..1308232 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1308225..1308674 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1308225..1308674 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1308667..1309398 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1308667..1309398 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1309416..1309913 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1309416..1309913 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1309914..1310190 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1310148 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1310158) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1310227..1310471) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1310268) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1310472..1310828) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1310472..1310828) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1310859..1310878) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1310876) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1310913..1310931 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310918 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1310997..1311743 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1310997..1311743 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1311798 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1312146..1312154 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1312168..1312187 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1312172 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1312224..1313423 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1312224..1313423 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1312306..1312312 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1312327..1312345 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1312333 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1313392..1313394 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313414..1313432 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1313426 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1313439..1313666 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1313439..1313666 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1313516..1313535) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1313524) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1313667..1313762 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1313763..1314461 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1313763..1314461 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1314414..1315240) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1314442..1314693 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1314442..1314693 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1314943..1314958 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1314966..1315177 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1314966 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1315142 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1315229..1315248) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315251) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1315264..1315271) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1315316..1315323 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1315338..1315357 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1315340 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1315376..1315666 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1315376..1315666 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1315703..1315786) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1315746) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1315787..1315972) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1315787..1315972) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1316005..1316024) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316016) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1316018..1316362) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1316038..1316045) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1316071..1316076 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1316092..1316111 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1316099 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1316138..1316332 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1316138..1316332 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1316308 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1316353..1316371) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316369) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1316388..1316393) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1316631..1317257 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1316631..1317257 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1317188 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1317314..1317319 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1317326 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1317335..1317353 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1317375..1318712 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1317375..1318712 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1318763..1319260 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1318763..1319260 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1319109..1319115 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1319124 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1319130..1319148 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1319234 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1319355..1319361 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319372..1319391 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319384 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1319388..1319495 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1319496..1321409 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1319496..1321409 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1319645..1319664) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319662) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319677..1319686) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1319813..1319832) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319838) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319846..1319852) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1321390 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1321466) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1321677..1321696) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321686) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1321710..1321717) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1321761..1321780 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1321771 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1321816..1322907 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1321816..1322907 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1322556 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1322886 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1322920..1323138) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1322931..1323188 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1323125..1323144) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323138) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1323160..1323167) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1323189..1324154 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1323189..1324154 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1324172..1324179 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1324194..1324213 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1324206 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1324217..1325083 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1324217..1325083 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1324938..1324942 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324959..1324978 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324967 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1325085 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1325130..1325281 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1325130..1325281 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1325130..1325281 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1325259..1325265 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325279..1325290 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325283 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1325312..1327411 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1325312..1327411 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1327429..1327433 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1327449..1327468 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1327460 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1327509..1327775 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1327509..1327775 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1327775..1329487 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1327775..1329487 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1329474 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1329527..1329533 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329548..1329559 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329551 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1329578..1329817 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1329578..1329817 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1329598..1330937) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1329895..1330923 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1329895..1330923 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1330893 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1330938..1331618) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1330938..1331618) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1331628..1331647) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1331651) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1331662..1331669) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1331703..1331710 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1331724..1331742 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1331730 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1331753..1333720 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1331753..1333720 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1332193..1332208) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1332205) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1333691 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1333764..1333766 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1333782..1333801 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1333792 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1333834) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1333858..1334724 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1333858..1334724 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1334704 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1334763..1335536) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1334763..1335536) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1334780) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1335568..1335587) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1335578) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1335811..1335830 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1335824 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1335826..1335929 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1335873..1337987 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1335873..1337987 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1337166..1337184) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337178) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337200..1337205) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1337968 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1338060..1338068 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338080..1338098 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338092 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1338151..1339971 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1338151..1339971 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1339982..1341163) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1339982..1341163) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1340016) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1341191..1341210) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1341207) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1341239..1341257) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1341251) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1341253..1341321) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1341272..1341277) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1341315..1341334) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1341321) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1341365..1341526) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1341365..1341526) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1341549..1341568) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1341562) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1341582..1341589) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1341663..1341670 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1341682 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1341683..1341701 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1341730..1342641 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1341730..1342641 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1341735) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1342184..1342192 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342206..1342223 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342209 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1342626 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1342685..1343149) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1342685..1343149) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1342703) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1343179..1343198) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1343189) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1343213..1343220) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1343275..1344567) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1343275..1344567) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1343297) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1344591..1344610) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1344595) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1344626..1344630) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1344643..1345137) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1344643..1345137) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1345153..1345172) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1345169) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1345186..1345195) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1345194..1346054) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1345194..1346054) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1346075..1346094) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1346088) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1346125..1346132 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1346148..1346167 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1346161 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1346197..1346961 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1346197..1346961 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1346962..1347110 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1347091..1347109 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1347112..1347261 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1347112 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1347159) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1347262..1348992 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1347262..1348992 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1349058..1349576 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1349058..1349576 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1349574 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1349619..1349624 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1349637..1349656 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1349640 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1349672..1350220 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1349672..1350220 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1350221..1350372 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1350373..1351596 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1350373..1351596 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1351559..1351577) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1351569) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1351575 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1351592..1351597) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1351645..1351652 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1351664..1351765 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1351664 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1351667..1351686 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1351682..1351765 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1351682..1351765 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1351722 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1351776..1351781 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1351796..1352080 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1351796 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1351798..1351816 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1352057..1352063 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1352077..1352088 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1352082..1352169 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1352082 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1352158..1352177 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1352171 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1352242..1352481 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1352242..1352481 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1352482..1352590 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1352591..1353109 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1352591..1353109 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1353146..1353153 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1353167..1353186 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1353181 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1353243..1353440 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1353243..1353440 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1353436 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1353481..1353577 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1353578..1354021 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1353578..1354021 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1354022..1354129 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1354097..1354102 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1354117..1354136 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1354131 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1354170..1355051 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1354170..1355051 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1355030 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1355086..1355093 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1355108..1355127 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1355113 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1355163..1355639 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1355163..1355639 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1355629..1356522 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1355629..1356522 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1356538..1356993 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1356538..1356993 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1356809..1356828) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356822) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1356842..1356850) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1356987 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1357032..1357039 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1357053..1357072 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1357054 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1357098..1357808 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1357098..1357808 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1357107) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1357217..1357221) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1357217) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1357878..1359002 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1357878..1359002 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1359014..1359020 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359034..1359045 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359036 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1359040..1359054) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1359064..1359068) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1359064..1359309 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1359064..1359309 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1359065) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1359297 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1359342..1360292 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1359346..1360149) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1359346..1360149) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1359358) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1360200..1360219) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360209) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1360233..1360240) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1360265..1360272 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1360287..1360306 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1360294..1360385 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1360294 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1360386..1360928 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1360386..1360928 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1361000..1361446 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1361000..1361446 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1361454 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1361839..1361846 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1361859 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1361861..1361880 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1361912..1362487 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1361912..1362487 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1362465 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1362528..1363493) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1362528..1363493) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1362541) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1362837..1362838 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362856..1362875 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1362862..1363586 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1362862 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1363514..1363532) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363535) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1363547..1363552) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1363573..1363579 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1363589 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1363593..1363612 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1363630..1364229 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1363630..1364229 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1364280..1365299 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1364280..1365299 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1365317..1366609 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1365317..1366609 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1366570..1367091 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1366570..1367091 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1367091..1367564 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1367091..1367564 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1367557..1367790 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1367557..1367790 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1367769 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1367835..1367840 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1367857..1367875 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1367865 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1367877..1367963 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1367953..1367956 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1367965 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1367971..1367990 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1368014..1369771 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1368014..1369771 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1369783..1371597 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1369783..1371597 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1370220..1370239) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370230) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1370254..1370261) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1371648..1371657 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371669..1371684 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371673 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1371707..1372402 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1371707..1372402 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1372407..1373540 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1372407..1373540 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1373541..1374233 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1373541..1374233 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1374230..1375423 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1374230..1375423 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1375401 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1375472..1375478 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375492..1375503 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375500 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1375545..1375552 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1375567..1375586 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1375572..1375663 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1375572 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1375627..1375634 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375648..1375667 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375665 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1375703..1376458 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1375703..1376458 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1375851) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1375853..1375855) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1376455..1377366 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1376455..1377366 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1377381..1379288 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1377381..1379288 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1379273 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1379357..1379364 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1379375..1379394 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1379378 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1379433..1380014 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1379433..1380014 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1379999 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1380043 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1380048..1380317) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1380048..1380317) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1380053) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1380318..1380383) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1380364..1380383) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1380383) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1380436..1380443 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380454..1380473 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380458 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1380498..1382120 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1380498..1382120 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1382108 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1382177..1383088 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1382177..1383088 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1383093 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1383122..1384354) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1383122..1384354) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1383133) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1384372..1384391) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384396) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1384406..1384411) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1384464..1384598) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1384464..1384598) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1384475) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1384620..1384638) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384631) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1384633..1384698) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1384654..1384659) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1384699..1385706) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1384699..1385706) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1385752) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1385753..1385761) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1385775..1385783) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1385893..1385902 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1385914 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1385915..1385930 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1385917..1385989 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1385990..1386268 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1385990..1386268 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1386266 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1386300..1387929) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1386311..1386415 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1386323) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1386397..1386404 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386416..1386435 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386417 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1386458..1387744 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1386458..1387744 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1387760..1388593 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1387760..1388593 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1387926..1387944) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387941) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387960..1387965) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1388656..1389321 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1388656..1389321 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1389305 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1389412..1389418 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1389433..1389452) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1389433..1389452 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1389445 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1389447) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1389476..1391209 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1389476..1391209 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1390604..1391208) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1391198 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1391243..1392910) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1391243..1392910) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1391253) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1392916..1393125) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1392916..1393125) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1393162..1393181) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1393184) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1393186..1393363) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1393196..1393199) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1393364) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1393366..1393377) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1393391..1393397) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1393436..1393443 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393457..1393476 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393473 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1393511..1394284 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1393511..1394284 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1394255 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1394320..1394874) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1394320..1394874) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1394331) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1394896..1394915) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1394906) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1394930..1394937) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1394959 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1394983) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1394984..1395142) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1394984..1395142) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1395049..1395192) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1395049..1395192) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1395138..1395142 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1395143..1395211) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1395152..1395166 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395179 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1395195..1395214) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395224) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1395227..1395236) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395298..1395305 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395319..1395338 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395323 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1395356..1396027 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1395356..1396027 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1395695..1395704 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395717..1395735 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395729 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1395974 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1396202..1396207 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396224..1396243 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1396225..1396450 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1396225 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1396229..1396248) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1396245) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1396349..1396357) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1396355) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1396371..1396379) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1396451..1397566 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1396451..1397566 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1397570..1398547 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1397570..1398547 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1398548..1398661 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1398582..1398601) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1398599) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1398616..1398619) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1398662..1399990 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1398662..1399990 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1398806..1398813 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398828..1398847 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398831 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1399995..1401407 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1399995..1401407 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1401404 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1401452..1401826) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1401452..1401826) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1401500) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1401857..1401876) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1401867) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1402030..1402035 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1402051..1402069 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1402061 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1402065..1402174 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1402097) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1402158..1402165 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1402176 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1402180..1402199 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1402195..1402405 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1402195..1402405 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1402245..1402364 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1402245..1402364 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1402251) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1402351 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1402396..1403999 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1402404..1403876) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1402404..1403876) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1402422) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1403877..1403972) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1403955..1403974) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403972) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1403979..1403982 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1403989..1403996) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403997..1404016 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404001 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1404061..1404327 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1404061..1404327 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1404309 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1404360..1404998) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1404360..1404998) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1404385) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1405019..1405038) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1405043) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1405053..1405057) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1405068..1405074 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405089..1405107 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1405090 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1405128..1405137 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405150..1405169 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1405154..1405237 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1405154 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1405238..1405426 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1405238..1405426 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1405243) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1405419 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1405441) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1405449..1405452) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1405496..1405499 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405516..1405535 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1405519 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1405566..1406363 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1405566..1406363 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1406389..1406817 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1406389..1406817 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1406774 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1406818..1407771 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1406893) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1406895..1407809) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1406895..1407809) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1407875..1407894) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407883) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407909..1407916) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1408161..1409726) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1408161..1409726) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1409761..1409780) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409772) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409794..1409801) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1410011..1411951 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1410011..1411951 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1411941..1412210 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1411941..1412210 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1412176..1412180 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1412194..1412213 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1412207 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1412210..1412731 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1412210..1412731 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1412728..1413021 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1412728..1413021 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1413061..1413672) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1413061..1413672) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1413075) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1413704..1413723) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1413713) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1413738..1413741) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1413928) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1413945..1414133) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1413945..1414133) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1413999) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1414155..1414174) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414172) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414187..1414194) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1414200..1414219 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1414207 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1414246..1416084 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1414246..1416084 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1416141..1416458 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1416141..1416458 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1416432 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1416507) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1416514..1416723) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1416514..1416723) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1416737..1416756) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1416752) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1416806..1417435) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1416806..1417435) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1416837) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1417337..1417355) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417343) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1417367..1417375) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1417470..1417481) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417475) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1417487..1417492 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1417496..1417502) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417508..1417526 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1417508 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1417509..1417589 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1417590..1418918 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1417590..1418918 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1418774..1418921) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1418817) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1418919..1419509 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1418922..1419407) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1418922..1419407) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1419419..1419438) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1419447) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1419453..1419460) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1419510..1420439 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1419510..1420439 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1420024..1420043 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1420033 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1420463..1420466 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1420481..1420500 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1420489 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1420537..1420818 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1420537..1420818 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1420807 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1420881..1420884 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1420897..1421023 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1420897 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1420902..1420908 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1421024..1422235 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1421024..1422235 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1422245..1422249 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422264..1422283 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422283 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1422310..1425756 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1422310..1425756 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1425322..1425340) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1425342) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1425356..1425361) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1425736 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1425781 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1425813) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1425825 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1426159..1427079) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1426159..1427079) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1426165) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1427119..1427138) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1427134) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1427152..1427159) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1427214..1427221 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427235..1427254 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1427236..1427341 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1427236 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1427343..1427433 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1427343 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1427349..1427352 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427367..1427383 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1427434..1428351 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1427434..1428351 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1428380 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1428399 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1428400..1428405 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1428459..1428464 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1428479..1428497 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1428487..1428590 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1428487 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1428591..1429661 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1428591..1429661 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1429694..1431562 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1429694..1431562 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1431562..1432185 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1431562..1432185 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1432188..1432520 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1432188..1432520 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1432547..1433440 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1432547..1433440 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1433415 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1433472..1433834) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1433472..1433834) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1433491) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1433827..1433831 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433840..1433853 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1433858..1433877) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1433862..1433973 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1433862 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1433870) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1433892..1433899) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1433974..1434420 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1433974..1434420 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1434006..1434013 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1434025..1434044 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1434030 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1434429..1434436 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1434450..1434469 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1434461 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1434504..1435544 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1434504..1435544 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1435467..1435485) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1435472) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1435501..1435506) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1435524 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1435708..1435717 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1435731..1435750 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1435745 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1435776..1436174 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1435776..1436174 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1435780) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1436190..1436429 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1436190..1436429 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1436408 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1436496..1436503 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1436514..1436533 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1436519 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1436545..1436994 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1436545..1436994 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1436980 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1437049..1437321 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1437049..1437321 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1437126..1437349) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1437324..1437444 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1437324..1437444 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1437351..1437474) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1437394) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1437445..1437550 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1437475..1437487) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1437482) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1437502..1437508) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1437531..1437535 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1437551..1437570 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1437552..1437643 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1437552 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1437644..1438198 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1437644..1438198 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1438203..1438688 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1438203..1438688 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1438655 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1438699..1439925) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1438699..1439925) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1438700..1439974 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1439926..1440027) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1439949..1439956 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439968..1439987 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1439976..1440105 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1439976 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1440022..1440040) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440037) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440057..1440062) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1440106..1440888 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1440106..1440888 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1440668..1440674 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440688..1440699 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1440699 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1440890..1441915 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1440890..1441915 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1441799 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1441932..1443179) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1441932..1443179) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1441959) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1443096..1443102 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1443116..1443127 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1443120 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1443176..1443361) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1443176..1443361) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1443194..1443198 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1443214..1443233 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1443223..1443358 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1443223 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1443252..1443271) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1443262) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1443285..1443292) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1443329..1443336 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443350..1443369 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443360 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1443389..1443907 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1443389..1443907 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1443929..1444108 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1443929..1444108 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1444088 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1444131) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1444135..1444138) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1444189..1444194 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1444210..1444228 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1444211 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1444254..1444835 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1444254..1444835 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1444836 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1444892..1445374) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1444892..1445374) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1444911) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1445364 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1445397..1445416) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1445416) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1445430..1445437) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1445474..1445480 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1445492..1445511 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1445494 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1445534..1446430 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1445534..1446430 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1446501..1448120 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1446501..1448120 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1448092 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1448154..1448157 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1448172..1448245 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1448172..1448191 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448172 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1448229) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1448246..1448677 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1448246..1448677 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1448747..1449682 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1448747..1449682 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1449349..1450801) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1449722..1450075 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1449722..1450075 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1450072..1452222 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1450072..1452222 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1450782..1450800) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1450801) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1450815..1450821) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1452205 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1452277..1452282 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1452298..1452316 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1452298 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1452339..1454279 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1452339..1454279 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1454075..1454081 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1454096..1454104 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1454102 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1454252 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1454297..1454364 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1454334..1454338 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1454354..1454373 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1454366..1454454 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1454366 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1454455..1455939 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1454455..1455939 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1455940..1456050 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1456051..1457025 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1456051..1457025 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1457026..1458381 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1457026..1458381 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1458205..1458210 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1458226..1458244 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1458236 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1458442..1459542 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1458442..1459542 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1459543..1459664 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1459665..1460756 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1459665..1460756 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1460145..1460154 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1460167..1460182 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1460172 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1460178..1460278 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1460238 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1460788..1461699 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1460788..1461699 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1461717 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1461829..1462620 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1461829..1462620 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1462617..1463312 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1462617..1463312 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1463335..1464042 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1463335..1464042 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1464060..1464425 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1464060..1464425 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1464277..1464280 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1464296..1464315 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1464312 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1464426..1464598 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1464599..1465921 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1464599..1465921 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1464806) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1464810..1464814) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1464829..1464833) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1465957..1467105 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1465957..1467105 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1467079 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1467200,1467207) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1467201..1467206 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1467207..1467252 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1467217..1467224 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1467237..1467256 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1467254 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1467311..1468105 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1467311..1468105 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1468023..1468026 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1468041..1468060 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1468049 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1468118..1468219 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1468118..1468219 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1468206 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1468307..1469587 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1468307..1469587 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1469528..1469544) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1469533) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1469608..1469613 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1469629..1469647 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1469633 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1469670..1469915 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1469670..1469915 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1469831..1469839 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1469850..1469868 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1469858 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1469916..1470026 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1470018..1470037 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1470028 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1470078..1470914 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1470078..1470914 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1470921..1471613 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1470921..1471613 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1471610..1472065 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1471610..1472065 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1472072..1472344 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1472072..1472344 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1472333 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1472405..1473178 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1472405..1473178 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1472894..1472901 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472915..1472933 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1472938 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1473179..1473271 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1473272..1473766 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1473272..1473766 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1473779..1473786 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473800..1473819 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473807 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1473829..1474055 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1473829..1474055 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1474022 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1474108..1476873 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1474108..1476873 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1476864 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1476919) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1476954..1476960 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1476975..1476986 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1476975 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1477018..1477392 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1477018..1477392 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1477424..1477428 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1477443 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1477444..1477463 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1477495..1477959 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1477495..1477959 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1477961..1478872 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1477961..1478872 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1478867..1478874 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1478889..1478908 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1478903 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1478912..1479028 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1478912..1479028 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1479055..1479600 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1479055..1479600 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1479249) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1479591 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1479604..1479721 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1479604..1479721 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1479774..1481081 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1479774..1481081 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1481082..1481196 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1481082..1481196 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1481227..1482141 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1481227..1482141 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1482125..1483411 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1482125..1483411 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1483408..1484502 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1483408..1484502 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1484487..1487702 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1484487..1487702 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1487699..1488469 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1487699..1488469 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1488469..1489404 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1488469..1489404 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1489373..1490092 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1489373..1490092 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1490071..1490721 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1490071..1490721 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1490723 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1490768..1490840 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1490820..1490827 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1490841..1490860 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1490842 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1490866..1490971 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1490866..1490971 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1490972..1491132 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1491133..1491834 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1491133..1491834 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1491846..1492910 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1491846..1492910 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1492959..1494107 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1492959..1494107 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1493048) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1493060..1493064) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1493082..1493083) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1494120..1494713 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1494120..1494713 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1494714..1494811 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1494812..1495585 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1494812..1495585 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1495490..1495497 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1495512..1495531 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1495513 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1495588..1496373 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1495588..1496373 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1496354..1496842 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1496354..1496842 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1496822 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1496869) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1496882..1498600) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1496882..1498600) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1498622..1498641) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1498636..1498641 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1498636) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1498654..1498659) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1498657..1498675 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1498661 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1498716..1501388 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1498716..1501388 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1500121..1500140) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1500132) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1500155..1500162) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1501394..1501413 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1501397..1501470 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1501397 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1501471..1502346 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1501471..1502346 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1502423..1502692 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1502423..1502692 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1502503..1502507) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1502508) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1502700..1503314 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1502700..1503314 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1503318..1503521 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1503318..1503521 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1503510 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1503602..1504822 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1503602..1504822 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1504661..1505236) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1504819..1507236 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1504819..1507236 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1505232..1505250) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1505236) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1505264..1505270) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1507087..1507091 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1507107..1507126 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1507118 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1507263..1507745 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1507263..1507745 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1507750..1508703 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1507750..1508703 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1508690..1510033 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1508690..1510033 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1510037..1511128 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1510037..1511128 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1511135..1511899 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1511135..1511899 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1511188 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1511893..1513839 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1511893..1513839 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1513748..1513754 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1513768..1513786 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1513784 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1513854..1514750 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1513854..1514750 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1514755..1515408 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1514755..1515408 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1515406..1515415 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1515429..1515448 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1515434 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1515481..1516125 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1515481..1516125 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1515886..1515892 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1515903 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1515907..1515925 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1516016..1516021 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1516037..1516055 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1516050 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1516126..1516196 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1516197..1516277 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1516197..1516277 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1516292 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1516337..1516709 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1516350..1516538) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1516350..1516538) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1516366) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1516412) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1516539..1516631) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1516613..1516632) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1516631) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1516648..1516651) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1516682..1516689 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1516704..1516722 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1516711 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1516750..1516753 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1516768..1516787 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1516776 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1516815..1517177 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1516815..1517177 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1517028) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1517193..1518854 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1517193..1518854 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1518855..1518944 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1518917..1518924 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1518938..1518957 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1518946 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1518993..1519655 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1518993..1519655 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1519681..1520583 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1519681..1520583 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1520561..1522609 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1520561..1522609 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1522645..1522652 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1522667..1522686 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1522673 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1522718..1523284 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1522718..1523284 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1523298..1524299 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1523298..1524299 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1524318..1525271 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1524318..1525271 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1525264..1526004 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1525264..1526004 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1526035..1526039 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1526055..1526074 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1526060 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1526088..1526321 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1526088..1526321 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1526302 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1526330..1526430 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1526390..1526460 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1526390 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1526461..1527210 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1526461..1527210 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1527182 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1527252..1527258 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1527270..1527289 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527292 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1527311..1530871 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1527311..1530871 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1530805..1531875) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1530891..1531880 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1530891..1531880 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1531867 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1531917..1532402) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1531917..1532402) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1531920) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1532424..1532442) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1532440) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1532456..1532463) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1532505..1532511 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1532526..1532545 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1532528 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1532579..1532911 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1532579..1532911 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1532582) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1532925..1534265 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1532925..1534265 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1534266..1534370 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1534371..1534643 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1534371..1534643 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1534643..1534888 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1534643..1534888 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1534860 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1534905..1535009 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1535010..1535396 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1535010..1535396 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1535401..1535925 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1535401..1535925 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1535922..1536653 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1535922..1536653 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1536659..1536666 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1536680..1536699 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1536684 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1536732..1536773 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1536732..1536773 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1536793..1537140 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1536793..1537140 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1537142 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1537195..1537201 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1537214..1537282 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1537214 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1537215..1537234 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1537283..1538131 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1537283..1538131 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1538152..1538159 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1538172..1538190 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1538182 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1538202..1538969 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1538202..1538969 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1539001..1540731 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1539001..1540731 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1540238) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1540239..1540258) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1540273..1540280) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1540728..1541009 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1540728..1541009 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1540841 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1541010..1541129 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1541101..1541108 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1541122..1541141 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1541131 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1541182..1542339 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1541182..1542339 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1541254..1541354) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1541294) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1542368..1543270 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1542368..1543270 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1543260 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1543331..1544224 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1543331..1544224 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1544230..1544237 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1544252..1544271 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1544259..1544411 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1544259 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1544412..1546487 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1544412..1546487 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1546457 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1546519..1546524 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1546531 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1546540..1546558 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1546563..1547870 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1546563..1547870 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1547876..1547880 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1547897..1547916 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1547907 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1547938..1548852 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1547938..1548852 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1547977..1547981 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1547994 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1547997..1548016 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1548865..1549410 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1548865..1549410 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1549427..1550830 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1549427..1550830 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1550870..1551649 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1550870..1551649 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1551624 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1551668 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1551769..1551776 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1551789..1551807 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1551800..1551953 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1551800 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1551928..1551935 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1551950..1551969 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1551955 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1552029..1552418 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1552029..1552418 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1552418..1552870 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1552418..1552870 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1552871..1552872 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1552927..1553691 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1552927..1553691 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1553701..1553707 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1553720..1554223 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1553720..1554223 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1553722..1553733 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1553736 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1554219..1554225 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1554240..1554259 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1554242..1554366 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1554242 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1554367..1555107 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1554367..1555107 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1555089 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1555134..1555208 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1555209..1556090 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1555209..1556090 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1556091..1556235 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1556236..1556958 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1556236..1556958 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1556960..1557517 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1556960..1557517 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1557464) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1557506..1557509 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1557524..1557543 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1557542..1557647 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1557542 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1557648..1558430 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1557648..1558430 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1558434..1559243 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1558434..1559243 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1559224..1559231 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1559246..1559265 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1559247 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1559305..1560456 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1559305..1560456 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1560463..1561731 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1560463..1561731 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1561764..1563458 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1561764..1563458 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1563459..1563566 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1563567..1567880 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1563567..1567880 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1567881..1567945 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1567891..1568108 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1567891..1568108 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1567917..1567923 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1567938..1567949 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1567947..1568014 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1567947 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1567997..1568003 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1568016..1568209 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1568016 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1568017..1568036 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1568210..1568680 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1568210..1568680 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1568531) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1568715..1569830 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1568715..1569830 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1568777..1568877) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1568817) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1569844..1570119 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1569844..1570119 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1570121..1570423 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1570121..1570423 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1570443..1572593 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1570443..1572593 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1572488..1572494 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1572503 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1572509..1572527 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1572590..1572868 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1572590..1572868 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1572885..1573238 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1572885..1573238 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1573229 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1573320..1574249 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1573320..1574249 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1574034..1574041 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574055..1574074 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574064 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1574268..1575218 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1574268..1575218 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1575251..1575257 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1575258..1575374 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1575258 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1575272..1575291 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1575375..1575644 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1575375..1575644 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1575627 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1575672..1575757 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1575738..1575741 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1575757..1575776 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1575759 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1575817..1577934 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1575817..1577934 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1577717 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1577918 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1577963..1578051 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1578052..1579011 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1578052..1579011 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1578120..1578128) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1578123) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1578142..1578149) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1578615..1578620 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578636..1578654 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578641 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1579051..1580280 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1579051..1580280 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1580269 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1580309..1580314 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1580324 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1580330..1580348 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1580358..1580615 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1580358..1580615 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1580616..1580670 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1580643 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1580712..1580721 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1580731..1580800 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1580731 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1580735..1580754 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1580801..1581694 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1580801..1581694 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1581697..1582299 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1581697..1582299 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1582353..1582372 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1582353..1582424 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1582353 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1582425..1583465 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1582425..1583465 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1583466..1583556 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1583557..1584771 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1583557..1584771 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1584802..1585674 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1584802..1585674 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1585145..1586329) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1585681 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1585774..1585777 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1585791 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1585793..1585812 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1585852..1587519 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1585852..1587519 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1586316..1586334) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1586333) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1586350..1586355) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1587507 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1587574..1587580 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1587594..1587605 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1587595 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1587635..1588372 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1587635..1588372 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1588369..1588581 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1588369..1588581 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1588609..1588628 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1588623 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1588712..1591075 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1588712..1591075 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1591076..1591176 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1591137..1591144 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1591159..1591178 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1591177 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1591219..1591944 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1591219..1591944 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1591931 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1592000..1592006 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1592019 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1592021..1592032 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1592083..1593291 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1592083..1593291 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1593249 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1593360..1593367 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1593380..1593399 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1593402 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1593414..1593417 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1593433..1593445 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1593447 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1593471..1594751 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1593471..1594751 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1594748..1596034 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1594748..1596034 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1595884 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1596035..1596088 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1596089..1596817 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1596089..1596817 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1596833..1596839 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1596851 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1596853..1596864 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1596864) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1596875..1596889) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1596898..1596902) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1596898..1597155 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1596898..1597155 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1597140 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1597172) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1597213..1597216 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1597231..1597250 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1597231 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1597285..1597800 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1597285..1597800 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1597736..1598074 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1597736..1598074 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1598141..1599007 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1598141..1599007 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1598204..1598304 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1598264 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1598967 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1599057..1599638 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1599057..1599638 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1599656..1600906 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1599656..1600906 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1600907..1601033 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1601013..1601020 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1601035..1601054 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1601035 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1601079..1602125 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1601079..1602125 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1602137 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1602182..1602247 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1602219..1602228 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1602241..1602256 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1602249 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1602293..1603468 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1602293..1603468 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1603469..1603568 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1603542..1603549 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1603563..1603582 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1603570..1603743 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1603570 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1603744..1605306 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1603744..1605306 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1605283 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1605375..1606169 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1605375..1606169 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1605924..1605929 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1605945..1605963 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1605965 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1606213..1606218 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1606229..1606368 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1606229 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1606234..1606252 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1606261) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1606272..1606285) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1606294..1606298) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1606305) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1606369..1606629 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1606369..1606629 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1606581 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1606613) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1606625 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1606670..1606844 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1606828..1606835 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1606846 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1606850..1606869 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1606895..1607938 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1606895..1607938 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1607951..1609129 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1607951..1609129 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1609111 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1609209..1609212 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1609221 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1609227..1609246 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1609277..1610806 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1609277..1610806 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1610808..1611239 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1610808..1611239 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1611222 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1611370..1611375 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1611391..1611409 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1611399..1611500 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1611399 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1611501..1612046 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1611501..1612046 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1612040 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1612047) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1612104..1612107 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1612122..1612141 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1612126 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1612179..1614755 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1612179..1614755 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1614771..1616654 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1614771..1616654 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1616557..1617051) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1616569 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1616579) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1616801..1616808 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1616823..1616842 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1616833..1616966 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1616833 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1616838..1616988) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1616838..1616988) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1616923 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1617052..1617507) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1617052..1617507) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1617508..1617599) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1617587..1617606) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1617599) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1617623..1617626) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1617662..1618219) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1617662..1618219) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1618310..1618311 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1618362) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1618368..1618724) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1618368..1618724) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1618784..1618797) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1618789) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1618803..1619627) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1618803..1619627) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1619649..1619668) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1619665) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1619680..1619686) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1619738..1621066) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1619738..1621066) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1619745) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1621089..1621108) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621108) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621122..1621130) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1621223..1621230 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1621238..1621257) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1621246..1621265 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621249) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1621252 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621270..1621277) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1621291..1621368 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1621291..1621368 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1621293) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1621346..1621522 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1621346..1621522 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1621503 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1621548..1621736 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1621731..1621750 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1621738 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1621802..1622509 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1621802..1622509 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1622520..1622526 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1622540..1622559 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1622544 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1622579..1623031 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1622579..1623031 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1623019 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1623045..1623398) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1623045..1623398) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1623086) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1623412..1623729) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1623412..1623729) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1623773..1623792) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623781) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623807..1623814) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1623866..1624141) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1623866..1624141) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1623867) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1624137..1624142 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1624158..1624176 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1624168..1624187) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1624178 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1624181) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1624200..1624209) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1624230..1624643 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1624230..1624643 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1624694 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1624700..1624719 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1624743..1625687 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1624743..1625687 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1625667..1625675 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1625686..1625704 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1625688 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1625727..1625948 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1625727..1625948 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1625738) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1625800..1625804) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1625804) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1625819..1625824) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1625948 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1626144..1626416 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1626144..1626416 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1626432..1626439 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1626453..1626472 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1626455 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1626498..1626728 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1626498..1626728 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1626729..1626805 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1626762 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1626807..1626914 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1626887..1626894 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1626908..1626927 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1626916 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1626971..1627363 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1626971..1627363 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1627323..1629425 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1627323..1629425 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1629443..1630432 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1629443..1630432 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1630392 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1630446..1631105) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1630461) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1630482..1631102 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1630482..1631102 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1631083 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1631118..1631122 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1631140..1631507 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1631140 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1631144..1631161 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1631150) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1631166..1631933) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1631166..1631933) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1631942..1631961) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1631965) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1631974..1631983) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1632087..1632092 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1632108..1632126 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1632108 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1632390..1632395 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1632412..1632430 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1632416..1632556 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1632416 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1632557..1633525 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1632557..1633525 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1633494 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1633589..1633597 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1633604 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1633608..1633627 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1633658..1634920 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1633658..1634920 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1634938..1636203 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1634938..1636203 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1636251..1636258 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1636273..1636292 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1636285 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1636313..1636720 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1636313..1636720 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1636319) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1636701..1636719 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1636726 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1636779) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1636779..1638113 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1636779..1638113 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1638090 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1638135..>1638184 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1638184..1638185 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1638185..1638937 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1638277..1638295) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1638295) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1638311..1638316) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1638938..1640329 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1638938..1640329 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1640360..1641961 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1640360..1641961 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1640476..1640781) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1640776..1640795) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1640781) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1640809..1640817) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1641959 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1642098..1643252) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1642098..1643252) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1642101) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1643151..1643329) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1643297..1643303 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1643312..1643331) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1643313..1643329 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1643323 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1643329) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643346..1643349) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1643356..1643363 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1643378..1643397 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1643389..1643493 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1643390 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1643494..1644831 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1643494..1644831 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1644832..1644906 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1644863 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1644982..1646481 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1644982..1646481 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1646482..1646797 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1646755 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1646964..1647599) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1646964..1647599) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1647636..1647655) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1647645) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1647670..1647677) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1647787..1647794 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1647809..1647828 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1647811..1648009 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1647811 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1648010..1649425 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1648010..1649425 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1649415 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1649518) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1649527..1650711) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1649527..1650711) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1650712..1650791) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1650784..1650802) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1650795) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1650818..1650823) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1651103..1651110 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651125..1651144 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651133 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1651175..1651636 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1651175..1651636 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1651666..1652100 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1651666..1652100 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1651849..1652154) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1651947 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1652101..1653197 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1652156..1652441) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1652199) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1652436..1652455) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1652441) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1652467..1652472) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1652703) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1652703..1652963) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1652703..1652963) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1652984..1653003) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1652994) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1653016..1653025) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1653198..1653323 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1653198..1653323 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1653324..1653440 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1653367..1653531 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1653367..1653531 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1653415..1653424 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653438..1653457 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1653442..1653752 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1653442 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1653733..1653740 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653754..1653773 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1653754 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1653805..1654644 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1653805..1654644 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1653827..1653846) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1653848) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1653861..1653864) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1654604 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1654750) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1654751..1655057) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1654767..1655054) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1654767..1655054) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1654794) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1654881..1654889 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654903..1654922 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654905 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1654916..1655076 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1655048 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1655097..1655819) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1655097..1655819) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1655102) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1655844..1655863) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1655852) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1655854..1655978) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1655979..1656335) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1655979..1656335) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1656359..1656378) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1656376) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1656394..1656398) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1656575) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1656581..1656781) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1656581..1656781) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1656764 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1656803..1656822) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1656815) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1656835..1656844) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1656956..1657144) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1656956..1657144) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1656972) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1657113..1657120) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1657126) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1657173..1657192) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657191) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1657207..1657214) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1657223..1657360 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1657223..1657360 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1657254..1657259 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1657274..1657292 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1657292..1657394 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1657292 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1657395..1657793 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1657395..1657793 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1657794..1658598 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1657858..1658292) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1657858..1658292) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1657874) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1658322..1658341) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658338) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658355..1658362) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1658599..1658787 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1658599..1658787 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1658788..1658873 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1658832 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1658902..1658908 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1658920..1659079 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1658920 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1658922..1658933 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1659080..1660642 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1659080..1660642 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1659383..1659402) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1659392) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1659417..1659424) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1660672..1661763 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1660672..1661763 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1661753..1662967 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1661753..1662967 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1663045..1663052 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1663067..1663086 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1663078 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1663114..1663920 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1663114..1663920 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1663728..1664826) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1663925..1664542 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1663925..1664542 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1664539..1666179 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1664539..1666179 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1664813..1664832) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664826) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664846..1664854) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1665819..1666585) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1666216..1666581 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1666216..1666581 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1666558 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1666578..1666858) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1666578..1666858) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1666587..1666718) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1666630) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1666678..1666687 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1666700..1666709) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1666701..1666720 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1666706 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1666708..1666806 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1666718) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1666720..1666850) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1666807..1667565 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1666807..1667565 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1666840 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1666856..1666875) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1666857) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1666890..1666897) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1667380..1667591) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1667544 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1667589..1668208 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1667592..1668131) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1667592..1668131) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1668132..1668146) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1668138) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668160..1668166) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1668186..1668195 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1668208..1668223 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1668210 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1668249..1668683 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1668249..1668683 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1668541..1668888 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1668541..1668888 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1668684..1669016 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1668975..1668984 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1668996..1669011 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1669018..1669196 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1669018 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1669087..1669166 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1669087..1669166 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1669153 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1669225..1669842) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1669225..1669842) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1669226) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1669866..1669885) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669887) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669899..1669906) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1669922..1669929 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1669941 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1669943..1669962 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1669992..1670309 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1669992..1670309 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1670009..1670027) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1670012) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1670041..1670048) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1670328..1670981 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1670328..1670981 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1670984..1670991 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1671005..1671024 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1671018 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1671045..1671278 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1671045..1671278 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1671279..1671414 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1671382..1671389 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1671403..1671422 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1671416 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1671447..1673450 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1671447..1673450 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1671651..1671670) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1671668) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1673440 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1673452..1674110) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1673550 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1673551..1673570 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1673603..1674049 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1673603..1674049 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1674073..1674092 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1674081 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1674092..1674109) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1674110) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674128..1674132) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1674135..1674353 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1674135..1674353 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1674365 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1674410..1674709 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1674427..1674600) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1674427..1674600) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1674440) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1674638..1674657) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1674645) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674671..1674678) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1674680..1674688 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1674700..1674719) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1674700..1674718 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1674711..1674819 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1674711 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1674712) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674734..1674741) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1674820..1675527 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1674820..1675527 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1675547..1675554 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1675566..1675585 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1675574 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1675616..1675978 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1675616..1675978 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1675996..1675999 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1676014..1676033 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1676025 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1676057..1676548 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1676057..1676548 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1676544 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1676579..1677007) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1676579..1677007) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1676596) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1677025..1677044) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677037) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1677039..1677124) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1677058..1677065) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1677095..1677104 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1677114..1677223 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1677114 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1677117..1677136 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1677119..1677138) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677124) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1677126..1677209) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1677153..1677156) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1677180 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1677241..1677633) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1677241..1677633) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1677254) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1677476..1677481 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1677497..1677515 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1677501 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1677611..1677615 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1677625..1677639 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1677640..1677659) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1677642 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1677655) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1677673..1677682) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1677714..1677860) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1677714..1677860) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1677735) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1677892..1678038) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1677892..1678038) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1678038..1678171 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1678038 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1678049..1678051 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1678054..1678065) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1678068) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1678080..1678086) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1678161..1678168 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1678173..1678265 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1678173 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1678183..1678202 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1678224) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1678266..1680995 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1678266..1680995 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1678286..1678290) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1678290) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1680996..1681066 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1681067..1681579 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1681067..1681579 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1681536 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1681605..1681611 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1681624 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1681626..1681637 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1681660..1681785 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1681660..1681785 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1681678) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1681799..1681805 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1681820..1681831 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1681822 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1681850..1681996 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1681850..1681996 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1682033..1682284 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1682033..1682284 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1682262 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1682305..1682310 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1682324..1682343 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1682328..1682419 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1682328 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1682420..1682785 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1682420..1682785 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1682801..1683100 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1682801..1683100 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1683076 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1683131..1683418) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1683131..1683418) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1683152) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1683218) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1683448..1683467) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1683460) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683483..1683490) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1683506..1684087) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1683506..1684087) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1684088..1684218 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1684113..1684132) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1684130) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1684203..1684206 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1684220 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1684222..1684241 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1684257..1684664 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1684257..1684664 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1684660 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1684726..1684729 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1684744..1684763 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1684748..1685062 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1684748 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1685063..1687030 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1685063..1687030 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1687034..1689454 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1687034..1689454 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1689434 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1689462..1689651) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1689501..1689677) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1689501..1689677) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1689505) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1689652..1690062) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1689652..1690062) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1690035..1690054) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690038) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690069..1690076) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1690103..1690122) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690104) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690137..1690144) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1690151..1690170) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690162) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690184..1690193) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1690410..1690415 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1690428..1690447 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1690433 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1690446..1690510 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1690511..1691908 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1690511..1691908 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1691897 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1691942 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1691998..1692744) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1692121..1692128 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1692140 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1692141..1692160 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1692211..1693710 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1692211..1693710 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1692743..1692762) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1692766) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1692776..1692785) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1693658 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1693778..1694041 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1693778..1694041 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1694300) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1694300..1695568) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1694300..1695568) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1695569..1695698) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1695699..1697240) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1695699..1697240) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1697241..1697562) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1697552..1697571) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697563) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697586..1697589) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1697789..1697796 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1697809..1697828 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1697816 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1697835..1698281 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1697835..1698281 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1698288..1699181 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1698288..1699181 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1698798..1698817 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1698806 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1699254..1699850 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1699254..1699850 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1699840 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1699899..1701098) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1699899..1701098) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1701099..1701170) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1701158..1701169) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1701170) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1701184..1701190) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1701268..1702803) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1701268..1702803) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1701280) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1702814..1703596) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1702814..1703596) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1703617..1704516) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1703617..1704516) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1704531..1704752) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1704531..1704752) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1704767..1706101) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1704767..1706101) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1706111..1707760) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1706111..1707760) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1706160..1706260 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1706220 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1707804..1708946) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1707804..1708946) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1708965..1708983) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1708982) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1708999..1709004) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1709037..1709342) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1709037..1709342) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1709332..1709505) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1709332..1709505) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1709613..1711145) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1709613..1711145) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1709624) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1711180..1711199) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711180) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711212..1711221) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1711281..1711673) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1711281..1711673) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1711312) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1711701..1711712) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711708) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711726..1711732) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1711780,1711787) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1711781..1711786 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1711787..1711892) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1711877..1711896) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711892) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711910..1711917) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1712166..1713641) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1712166..1713641) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1712178) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1713675..1714652) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1713675..1714652) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1714681..1714699) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714693) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714711..1714719) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1714786..1716177) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1714786..1716177) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1714800) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1714946 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1715967..1715973 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1715987..1716005 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1715998..1716331 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1715998 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1716178..1716282) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1716242..1716342) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1716282) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1716304..1716309 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1716325..1716343 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1716333 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1716391..1716398 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1716411..1716430 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1716414 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1716463..1717008 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1716463..1717008 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1716992 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1717102..1717174) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1717102..1717174) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1717200) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1717227..1717772) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1717227..1717772) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1717812..1717831) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717826) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717845..1717852) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1718088..1718318) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1718088..1718318) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1718102) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1718344..1718363) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1718356) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1718375..1718381) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1718410..1718429) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1718420) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1718433..1718440 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1718454..1718473 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1718458 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1718503..1720266 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1718503..1720266 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1720247 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1720367..1721224) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1720367..1721224) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1721270..1721289) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1721290) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1721303..1721310) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1721352..1722341 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1721352..1722341 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1721408..1722366) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1722398..1723879) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1722398..1723879) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1722411) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1723896..1728458) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1723896..1728458) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1726919..1727019 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1726979 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1728459..1728530) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1728510..1728529) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1728527..1728534 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1728530) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728544..1728551) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1728546 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1728549..1728568 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1728605..1729507 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1728605..1729507 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1729487 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1729559..1730674) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1729559..1730674) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1730671..1731564) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1730671..1731564) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1731569..1731588) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1731577 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1731587) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1731602..1731608) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1731617..1731635) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1731635) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1731651..1731656) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1731712..1732080) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1731712..1732080) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1732115..1732133) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1732138) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1732140..1732259) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1732145..1732153) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1732251..1732270) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732259) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1732261..1732357) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1732285..1732292) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1732380..1733096) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1732380..1733096) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1732402) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1733134..1733153) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733143) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733169..1733172) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1733197..1733203 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733217..1733235 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1733222 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1733247..1733552 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1733247..1733552 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1733536 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1733623..1734393 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1733623..1734393 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1734375..1734382 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1734394 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1734397..1734416 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1734437..1734970 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1734437..1734970 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1734971..1735056 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1735013 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1735049..1736293) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1735049..1736293) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1735058..1735797 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1735063) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1736294..1736386) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1736387..1737850) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1736387..1737850) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1737868..1738902) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1737868..1738902) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1738914..1738985) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1738957) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1738986..1739077) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1738986..1739077) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1739105..1739124) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1739117) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1739139..1739146) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1739159..1739166 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739180..1739199 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1739184 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1739226..1741268 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1739226..1741268 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1741276..1741285 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1741298..1741313 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1741301 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1741335..1741628 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1741335..1741628 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1741608 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1741653..1742000) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1741684) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1742001..1742405) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1742001..1742405) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1742406..1742501) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1742491..1742506) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1742491..1742610) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1742491..1742610) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1742501) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742519..1742528) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1742606..1742612 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742626..1742637 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1742637..1742845 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1742637 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1742680..1742802 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1742680..1742802 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1742846..1743139 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1742846..1743139 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1743140..1743233 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1743190 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1743255..1744940) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1743255..1744940) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1743267) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1744941..1745028) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1745020..1745038) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745028) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745052..1745059) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1745197..1745206 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1745216 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1745219..1745238 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1745265..1746716 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1745265..1746716 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1746692 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1746753..1747451) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1746753..1747451) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1746768) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1747486..1747505) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747505) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1747507..1747720) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1747519..1747526) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1747721..1748398) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1747721..1748398) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1748399..1750888) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1748571..1749608 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1748571..1749608 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1749805..1749811 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1749826..1749837 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1749838 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1749865..1750548 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1749865..1750548 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1750889..1751194) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1750889..1751194) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1751195..1751296) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1751275..1751294) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1751296) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1751309..1751316) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1751324..1751426) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1751366) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1751427..1752605) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1751427..1752605) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1752631..1752650) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752650) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752664..1752673) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1752728..1753216) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1752728..1753216) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1752753) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1753241..1753396) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1753241..1753396) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1753436..1754191) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1753436..1754191) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1754444..1754449 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754465..1754483 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1754480 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1754499..1754855 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1754499..1754855 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1754814..1755053) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1754814..1755053) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1754856..1755292 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1755054..1755155) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1755156..1755653) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1755156..1755653) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1755654..1755753) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1755754..1756665) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1755754..1756665) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1756687..1756698) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756689) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1756713..1756719) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1756949..1756956 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1756965 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1756971..1756990 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1757012..1757494 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1757012..1757494 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1757504..1757758 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1757504..1757758 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1757759..1757863 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1757864..1758658 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1757864..1758658 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1758659..1759669 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1758782..1759654) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1758782..1759654) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1759755..1760633 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1759755..1760633 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1760746..1760805) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1760781) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1760806..1761237) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1760806..1761237) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1761257..1761276) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761265) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1761267..1761500) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1761290..1761296) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1761501..1761519) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1761501..1762133) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1761501..1762133) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1761507) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1761535..1761540) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1762271..1762278 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1762293..1762312 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1762297 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1762359..1763279 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1762359..1763279 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1762790..1762809) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762805) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1762824..1762831) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1763280..1763937 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1763776..1764138) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1763776..1764138) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1764199..1764411) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1764199..1764411) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1764450..1764457 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1764472..1764491 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1764475 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1764515..1764778 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1764515..1764778 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1764756 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1765155..1767755) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1765155..1767755) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1767756..1767865) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1767781..1767788 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1767803..1767822 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1767811..1768438 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1767811 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1767855..1767874) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767865) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1767889..1767895) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1767911..1768370) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1767953) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1768415) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1768425..1769066) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1768425..1769066) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1769067..1769184) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1769161..1769180) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769184) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769194..1769196) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1769272,1769279) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1769273..1769278 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1769279..1769363 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1769279..1769356 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1769279..1769343) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1769279..1769363 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1769341 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1769374..1769706) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1769374..1769706) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1769388) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1769771..1770496) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1769771..1770496) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1770511..1771254) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1770511..1771254) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1771282..1771301) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771301) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771315..1771321) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1771332..1771907) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1771332..1771907) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1771913..1772614) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1771913..1772614) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1772644..1772663) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1772644) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1772648..1772663) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1772678..1772685) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1772678..1772685) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1772688) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1772691..1773173) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1772691..1773173) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1773212..1773229) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1773216) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1773227..1774168) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1773227..1774168) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1773260) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1774198..1774217) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774206) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774231..1774235) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1774239..1774248 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1774261..1774280 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1774269 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1774284..1774348 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1774320..1774325 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1774341..1774359 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1774350 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1774374..1774919 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1774374..1774919 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1774878 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1774946..1775269) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1774946..1775269) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1774953) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1775290..1775309) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775301) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775322..1775329) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1775390..1775396 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1775407 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1775411..1775430 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1775463..1776140 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1775463..1776140 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1776132 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1776230..1776766) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1776230..1776766) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1776253) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1776793..1776812) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776813) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776826..1776833) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1776903..1777685) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1776903..1777685) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1776912) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1777707..1777725) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777726) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1777739..1777745) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1777782..1777789 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1777804..1777823 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1777808 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1777856..1778353 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1777856..1778353 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1778360..1778363 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1778379..1778398 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1778381 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1778417..1779394 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1778417..1779394 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1779366 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1779491..1779498 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1779513..1779532 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1779520 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1779556..1780614 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1779556..1780614 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1780615..1780684 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1780668..1780674 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1780686..1780705 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1780686 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1780734..1781846 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1780734..1781846 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1781865..1782464 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1781865..1782464 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1782402 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1782446 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1782486..1782984) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1782522) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1782956..1782965 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1782968..1782986) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1782977..1783171 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1782977 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1782978..1782997 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782984) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1783003..1783008) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1783059..1783922) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1783059..1783922) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1783072) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1783128 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1783160) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1783173..1783940 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1783918..1783922 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1783931..1783945 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1783942 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1783961..1783980) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1783974) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1783976..1784169) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1783992..1783998) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1784170..1785945) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1784170..1785945) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1785946..1786076) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1786069..1786271) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1786069..1786271) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1786121) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1786269..1786288) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1786287) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1786289..1786481) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1786301..1786308) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1786510..1787136) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1786510..1787136) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1786526) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1787170..1787189) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1787183) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1787203..1787210) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1787287..1787778) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1787287..1787778) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1787296) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1787790..1787808) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1787802) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1787822..1787828) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1787853..1788185) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1787853..1788185) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1788186..1788476) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1788201..1788206 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1788221..1788239 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1788223 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1788263..1788490 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1788263..1788490 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1788477..1788953) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1788477..1788953) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1788491..1788998 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1788954..1789056) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1788971..1788976 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1788991..1789009 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1789000 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1789020..1789283 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1789020..1789283 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1789036..1789055) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789056) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1789058..1789583) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1789069..1789073) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1789288..1789521 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1789288..1789521 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1789508 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1789607..1789951) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1789607..1789951) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1789628) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1789952..1790024) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1790020..1790039) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790024) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1790026..1790129) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1790053..1790058) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1790116..1790131) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790129) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790144..1790153) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1790272) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1790308..1790511) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1790308..1790511) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1790532..1790551) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790550) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1790552..1790618) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1790567..1790574) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1790584..1790591 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1790603 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1790605..1790617) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1790605..1790624 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1790608..1790740 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1790629) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1790741..1792228 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1790741..1792228 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1791184..1791201) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791190) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1791214..1791222) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1792214 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1792276..1792281 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792297..1792315 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792302 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1792329..1794227 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1792329..1794227 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1793272..1793291) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1793280) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1793305..1793314) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1794217..1795062 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1794217..1795062 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1795063..1796569 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1795095..1796432) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1795095..1796432) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1795106) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1796460..1796479) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1796475) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1796477..1797635) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1796494..1796501) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1796553..1796556 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1796571..1796590 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1796571 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1796651..1797616 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1796651..1797616 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1797604 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1797666..1798919) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1797666..1798919) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1797680) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1798935..1801769) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1798935..1801769) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1801864..1801883) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1801879) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1801881..1801997) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1801898..1801905) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1801998..1803914) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1801998..1803914) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1803925..1804839) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1803925..1804839) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1804843..1804862) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1804858) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1804879..1804883) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1804903..1805493) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1804903..1805493) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1805586..1806830) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1805586..1806830) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1805588) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1806893..1806911) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1806906) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1806908..1807128) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1806924..1806931) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1807114..1807132) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807128) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807144..1807152) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807212..1808429) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1807212..1808429) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1807238) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1808462..1808481) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808470) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1808495..1808502) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1808665..1809288) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1808665..1809288) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1809289..1809439) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1809315..1809321 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1809327 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1809335..1809346 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1809353..1809361 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1809369..1809469 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1809373..1809391 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1809384 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1809422..1809440) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1809429..1809514 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1809429 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1809439) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1809456..1809462) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1809490..1809497 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1809510..1809529 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1809516 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1809554..1810912 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1809554..1810912 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1809896..1809907) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1809901) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1809921..1809927) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1810928..1811776 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1810928..1811776 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1811192..1811211) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811199) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1811225..1811233) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1811739 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1811771) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1811802..1812467) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1811802..1812467) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1811816) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1812486..1812836) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1812486..1812836) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1812833..1813111) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1812833..1813111) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1813138..1813157) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813154) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1813172..1813178) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1813187..1814083) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1813187..1814083) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1813925..1813934 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1813945 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1813948..1813967 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1813963..1814181 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1814107..1814126) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814127) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814138..1814145) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1814182..1814655 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1814182..1814655 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1814652 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1814690..1814926) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1814690..1814926) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1814698) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1814949..1814968) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814964) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814982..1814991) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1815011..1816345) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1815011..1816345) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1816346..1816481) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1816478..1816497) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1816488) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1816512..1816519) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1816577..1816584 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1816599..1816618 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1816602 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1816603..1816709 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1816710..1817099 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1816710..1817099 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1817109 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1817506..1817844) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1817506..1817844) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1817867..1817874 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1817888..1817907 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1817897 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1817901..1817973 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1817932..1817951) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1817935) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1817963..1817969) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1817974..1818582 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1817974..1818582 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1818572 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1818625..1819227) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1818625..1819227) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1819243..1820154) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1819243..1820154) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1820183..1820202) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820199) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820218..1820223) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1820275..1820278 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1820293..1820312 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1820295 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1820338..1820538 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1820338..1820538 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1820538..1822028 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1820538..1822028 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1821273..1821284) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821277) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1821298..1821304) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1822016 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1822063..1823463) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1822063..1823463) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1822087) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1823234..1823243 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1823255..1823270 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1823269 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1823483..1823502) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1823503) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1823516..1823523) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1823562..1823571 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1823577 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1823584..1823603 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1823616..1824317 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1823616..1824317 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1824342..1824350 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1824364..1824383 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1824369 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1824405..1824656 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1824405..1824656 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1824677 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1824727..1825548) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1824727..1825548) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1824753) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1825549..1825630) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1825631..1826332) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1825631..1826332) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1826333..1826422) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1826407..1826426) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826422) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1826442..1826446) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1826480..1826486 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1826501..1826512 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1826518 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1826534..1826659 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1826534..1826659 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1826657 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1826699..1827013) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1826699..1827013) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1826711) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1827034..1827052) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827041) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827063..1827071) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1827074..1827685) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1827074..1827685) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1827763..1827939) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1827763..1827939) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1827767) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1827778) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1827782..1827801) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1827817..1827820) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1827953..1827971) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1827974) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1827976..1828197) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1827987..1827992) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1827997..1828002 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1828017..1828035 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1828019 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1828058..1828201 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1828058..1828201 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1828198..1828878) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1828198..1828878) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1828202..1829213 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1828905..1828924) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828911) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828938..1828947) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1829029..1829253) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1829029..1829253) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1829043) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1829294..1829313) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1829306) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1829340..1829618) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1829340..1829618) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1829615..1831030) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1829615..1831030) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1830286..1830289 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1830305..1830324 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1830310 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1831059..1831886) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1831059..1831886) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1831864..1833174) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1831864..1833174) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1833183..1833836) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1833183..1833836) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1833821..1834510) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1833821..1834510) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1834517..1835851) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1834517..1835851) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1835832..1835987) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1835832..1835987) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1835870..1835888) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1835886) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1835904..1835909) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1835981..1836214) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1835981..1836214) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1835988) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1836090..1836094 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1836103..1836117 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1836118 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1836119..1836138) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1836128) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1836153..1836162) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1836174..1836953) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1836174..1836953) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1836982..1838262) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1836982..1838262) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1837630..1837648) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1837646) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1837662..1837669) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1838230..1838248) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838240) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838264..1838269) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838327..1838632) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1838327..1838632) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1838460) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1838656..1838675) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1838671) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1838689..1838698) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1838768..1838777 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1838791..1838810 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1838791 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1838812) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1838814..1838828) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1838837..1838841) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1838837..1839238 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1838837..1839238 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1839245..1840198 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1839245..1840198 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1840188 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1840269..1841417) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1840269..1841417) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1840286) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1841430..1841434 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1841443..1841462) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1841450..1841469 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841452) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1841460 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1841721..1841729 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1841743..1841762 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1841746 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1841787..1842812 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1841787..1842812 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1842190 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1842192..1842196 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1842206..1842207 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1842804 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1842856..1843287) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1842856..1843287) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1842861) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1843288..1843821) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1843288..1843821) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1843825..1843831 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1843842..1843952 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1843842 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1843844..1843863 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1843849..1843868) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843869) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1843884..1843885) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1843953..1844378 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1843953..1844378 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1844366 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1844411..1845642 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1844428..1845765) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1844428..1845765) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1845837..1846031) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1845837..1846031) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1845850) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1846044..1846607) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1846044..1846607) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1846617..1847384) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1846617..1847384) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1847408..1847427) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847425) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847438..1847445) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1847462..1848043) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1847462..1848043) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1848044..1848159) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1848191..1848442) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1848191..1848442) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1848204) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1848465..1848484) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1848479) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1848528..1849796) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1848528..1849796) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1849830..1849849) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849849) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1849861..1849868) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1850003..1850022 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1850006 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1850045..1851040 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1850045..1851040 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1851061..1851702 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1851061..1851702 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1851703..1852804 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1851741..1852361) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1851741..1852361) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1851767) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1852362..1852868) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1852362..1852868) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1852865..1853659) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1852865..1853659) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1853743..1854276) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1853743..1854276) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1853748) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1854206..1854211 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1854222..1855168 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1854224 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1854228..1854246 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1854294..1854905) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1854294..1854905) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1854937..1854956) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854956) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1854969..1854974) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1855125 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1855165..1855938) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1855165..1855938) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1855200) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1855980..1856414) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1855980..1856414) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1855992) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1856443..1856462) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1856454) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1856456..1856520) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1856476..1856483) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1856499) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1856521..1858197) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1856521..1858197) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1858198..1858388) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1858377..1858396) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858388) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858411..1858414) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1858486..1859619) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1858486..1859619) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1858502) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1859641..1859660) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1859644) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1859679..1860296) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1859679..1860296) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1860312..1860794) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1860312..1860794) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1860795..1860942) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1860933..1860951) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1860943) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1860962..1860970) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1860996..1861005 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1861018..1861033 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1861020..1861106 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1861020 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1861069..1861076 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1861091..1861110 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1861108 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1861137..1862042 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1861137..1862042 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1862077..1862096 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1862091 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1862092..1862272 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1862273..1863421 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1862273..1863421 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1862442..1863471) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1863417 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1863453..1863472) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863471) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863487..1863495) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1863502..1863648 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1863502..1863648 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1863541..1863548 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863562..1863581 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1863573..1863663 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1863573 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1863664..1863864 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1863664..1863864 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1863879 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1863916..1864098) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1863916..1864098) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1863924..1864229 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1863933) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1864159..1864177) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1864191..1864197) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1864195) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1864205..1864211 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1864226..1864237 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1864231 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1864254..1864523 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1864254..1864523 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1864378 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1864506 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1864551..1864733) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1864551..1864733) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1864571) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1864726..1865406) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1864726..1865406) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1865407..1865544) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1865423..1865428 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865441..1865460 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865446 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1865489..1866178 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1865489..1866178 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1865542..1865558) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1865545) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1865546..1865935) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1865916..1865935) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865933) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1865947..1865955) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1866178..1866576 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1866178..1866576 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1866569..1866575 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1866590..1866601 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1866601 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1866618..1866746 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1866618..1866746 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1866747..1867727 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1866754..1867644) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1866754..1867644) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1866791) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1867666..1867685) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867673) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1867697..1867703) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1867701 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1867745..1867891) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1867745..1867891) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1867761) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1867915) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1867916..1867927) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1867942..1867948) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1867966..1868223) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1867966..1868223) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1868243..1868262) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868258) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1868274..1868281) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1868288..1871869) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1868288..1871869) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1871870..1871941) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1871931..1871950) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1871941) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1871986..1872183) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1872029) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1872045..1872134) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1872045..1872134) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1872162..1872181) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872183) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872196..1872203) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1872205..1872711) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1872205..1872711) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1872715..1873812) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1872715..1873812) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1873830..1873841) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873833) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873856..1873862) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873886..1875202) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1873886..1875202) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1873899) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1875199..1875783) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1875199..1875783) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1875872..1875972) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1875872..1875972) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1875879) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1875973..1876113) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1876114..1877619) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1876114..1877619) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1877555..1877655) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1877595) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1877607 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1877645..1877664) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1877661) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1877678..1877685) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1877731..1878723) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1877731..1878723) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1877749) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1878768..1879358) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1878768..1879358) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1879360..1880334) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1879360..1880334) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1880372..1881391) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1880372..1881391) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1881439..1881458) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881449) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881470..1881477) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1881512..1881519 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1881533..1881612 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1881533 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1881534..1881553 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1881613..1882440 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1881613..1882440 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1882442..1883206 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1882442..1883206 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1883195 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1883237) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1883247..1885172) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1883247..1885172) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1885203..1885222) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885207) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1885209..1885273) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1885237..1885241) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1885274..1885465) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1885274..1885465) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1885484..1885502) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885493) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1885495..1885800) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1885518..1885523) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1885532..1885538 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1885553..1885564 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1885562 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1885629..1885781 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1885629..1885781 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1885791 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1885834..1886991) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1885834..1886991) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1885845) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1887079..1887479) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1887079..1887479) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1887089) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1887476..1887495) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887494) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887510..1887516) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1887538..1887834) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1887538..1887834) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1887859..1887878) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1887869) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1887892..1887899) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1887912..1888541) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1887912..1888541) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1888507) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1888543..1888770) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1888543..1888770) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1888798..1888817) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1888813) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1888815..1888969) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1888831..1888839) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1888854..1888982) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1888854..1888982) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1888969) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1888971..1889082) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1888972..1888991) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1889007..1889011) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1889083..1890324) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1889083..1890324) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1890038..1890056) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1890047) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1890071..1890078) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1890340..1892589) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1890340..1892589) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1892605..1892624) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1892621) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1892638..1892644) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1892692..1893198) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1892692..1893198) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1892715) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1893242..1893261) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1893259) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1893275..1893282) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1893280..1893289 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1893303..1893322 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1893315 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1893336..1893755 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1893336..1893755 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1893756..1893906 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1893776..1894153) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1893776..1894153) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1893809) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1894151..1894296 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1894183..1894201) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1894202) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1894215..1894224) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1894297..1894316 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1894298 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1894341..1894529 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1894341..1894529 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1894545 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1894568..1894939) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1894568..1894939) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1894601) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1894951..1894970) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1894964) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1894983..1894988) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1894985..1895230) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1894985..1895230) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1895256..1895274) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895261) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1895286..1895294) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1895380..1895386 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1895401..1895412 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1895408 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1895429..1895533 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1895429..1895533 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1895515 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1895558..1896520) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1895558..1896520) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1895688..1895697 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1895709..1895724 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1895709 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1895713..1896048 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1896019..1896023 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1896039..1896058 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1896050..1896560 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1896050 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1896521..1896977) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1896561..1897181 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1896561..1897181 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1896966..1896977) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1896977) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1896992..1896998) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1897203..1899947 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1897203..1899947 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1899617) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1899933 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1900023..1900517) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1900023..1900517) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1900036) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1900514..1901173) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1900514..1901173) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1901192..1901890) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1901192..1901890) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1901891..1901982) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1901983..1903275) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1901983..1903275) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1903276..1903337) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1903337..1903356) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903337) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1903371..1903378) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1903419..1904600) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1903419..1904600) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1903423) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1904623..1905108) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1904623..1905108) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1905056..1905075) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905073) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905088..1905095) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905117..1905287) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1905117..1905287) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1905288..1905359) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1905321..1905327 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1905342..1905361) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1905342..1905353 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1905349..1905423 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1905349 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1905359) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1905361..1905429) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1905377..1905383) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1905393 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1905430..1908225) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1905430..1908225) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1905898..1905902 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1905899 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1905904..1905908 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1906555..1906570) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1906569) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1906583..1906592) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1908226..1908350) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1908351..1908734) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1908351..1908734) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1908736..1909596) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1908736..1909596) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1909598..1910431) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1909598..1910431) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1910432..1910639) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1910634..1910653) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910639) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1910670..1910674) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1910677..1911654) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1910677..1911654) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1911639..1912832) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1911639..1912832) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1912837..1913970) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1912837..1913970) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1913967..1914677) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1913967..1914677) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1914670..1915083) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1914670..1915083) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1915099..1915902) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1915099..1915902) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1915914..1916249) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1915914..1916249) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1916269..1916288) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1916279) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1916302..1916309) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1916318..1916325 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1916334..1916353) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1916339..1916358 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1916345 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1916353) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1916389..1917261 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1916389..1917261 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1917303..1918097) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1917303..1918097) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1917328) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1918098..1918165) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1918166..1918723) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1918166..1918723) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1918724..1918803) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1918848) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1918870..1919637) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1918870..1919637) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1919672..1920346) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1919672..1920346) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1920348..1920851) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1920348..1920851) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1920860 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1920915..1920934) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920915) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1920949..1920956) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1920994..1921440) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1920994..1921440) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1921443 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1921495..1922034) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1921495..1922034) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1921508) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1922067..1922085) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1922078) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1922097..1922105) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1922106..1923377) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1922106..1923377) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1923378..1923445) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1923442..1923461) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923445) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1923475..1923482) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1923512..1923531) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1923518) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1923520..1923664) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1923542..1923549) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1923646..1923664) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1923664) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1923680..1923685) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1923713..1924999) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1923713..1924999) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1923736) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1925010..1926125) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1925010..1926125) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1926174..1927256) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1926174..1927256) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1927267..1928070) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1927267..1928070) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1927755..1927774) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1927772) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1927786..1927793) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1928063..1929265) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1928063..1929265) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1929246..1929893) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1929246..1929893) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1929340) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1929516..1929519) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1929516) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1929736) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1929898..1930650 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1929898..1930650) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1929898..1930650) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1929931..1929933) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1929934 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1930040,1930043) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930054,1930056) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930056,1930058) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930081,1930083) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930083,1930087) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930089,1930091) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930098,1930100) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930113,1930115) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930116,1930118) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930121,1930123) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930131,1930133) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930134,1930136) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930137,1930139) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930143,1930145) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930169,1930171) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930201,1930203) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930254,1930256) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930302,1930304) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930317,1930321) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930335,1930337) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930344,1930346) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930356,1930358) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930421,1930423) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930431,1930433) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930439,1930442) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930459,1930461) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930475,1930477) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930503,1930505) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930518,1930520) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930543,1930545) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930560,1930562) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1930575,1930577) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1930643..1931659) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1930643..1931659) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1931631..1933178) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1931631..1933178) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1933257..1933388) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1933300) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1933379..1933398) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1933388) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1933394..1933777) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1933394..1933777) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1933413..1933420) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1933774..1934862) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1933774..1934862) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1933903..1933918) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1933916) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1933931..1933939) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1934862..1936034) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1934862..1936034) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1936069..1936088) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1936086) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1936101..1936108) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1936109..1936879) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1936109..1936879) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1936905..1936924) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1936922) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1936936..1936942) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1936954..1937115) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1936997) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1937116..1937565) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1937116..1937565) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1937608..1937627) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1937615) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1937640..1937647) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1937681..1938727) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1937681..1938727) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1938669..1939370) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1938669..1939370) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1939377..1940132) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1939377..1940132) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1940133..1940218) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1940207..1940226) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1940218) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1940237..1940244) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1940296..1940523) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1940296..1940523) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1940317) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1940545..1941117) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1940545..1941117) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1941146..1941165) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1941156) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1941158..1941241) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1941178..1941184) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1941286) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1941305..1941583) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1941305..1941583) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1941584..1941809) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1941791..1941810) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1941809) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1941827..1941832) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1941957..1943435) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1941957..1943435) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1941970) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1943436..1943597) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1943584..1943602) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1943609) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1943616..1944350) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1943616..1944350) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1943617..1943622) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1943642) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1944372..1944575) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1944372..1944575) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1944611..1944630) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944632) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944644..1944651) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1944697..1944896) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1944740) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1944871..1944890) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944896) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944904..1944913) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1944913..1945950) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1944913..1945950) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1945968..1947278) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1945968..1947278) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1947279..1947403) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1947389..1947408) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947403) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1947423..1947426) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1947432..1947626) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1947432..1947626) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1947623..1948516) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1947623..1948516) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1948513..1949112) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1948513..1949112) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1948985..1948991 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1949000..1949183 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1949002 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1949005..1949016 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1949123..1949141) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949142) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949157..1949162) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1949190..1949321 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1949190..1949321 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1949309 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1949364..1950413) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1949364..1950413) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1949384) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1950288) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1950426..1951574) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1950426..1951574) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1950755..1950758 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1950782 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1950848 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1951552 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1951575..1951714) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1951713..1951732) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951714) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1951716..1951806) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1951747..1951754) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1951807..1952481) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1951807..1952481) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1952482..1952559) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1952560..1952736) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1952560..1952736) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1952748..1952766) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952765) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952781..1952787) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952781..1953434) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1952781..1953434) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1953464..1953483) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953477) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1953499..1953503) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953527..1954879) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1953527..1954879) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1953542) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1954914..1955831) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1954914..1955831) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1955302) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1955453..1955460) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1955456) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1955869..1955880) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955878) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1955894..1955900) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955970..1956626) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1955970..1956626) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1955984) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1956651..1956670) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1956666) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1956746..1957720) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1956746..1957720) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1956754) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1957574..1957579 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1957595..1957613 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1957605..1957798 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1957605 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1957756 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1957829..1959112) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1957829..1959112) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1957832) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1957870..1957876 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1957888..1957892 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1957888 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1959155..1959174) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959176) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1959189..1959196) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1959268..1959852) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1959268..1959852) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1959270) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1959853..1959934) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1959927..1959946) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1959934) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1959960..1959967) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1960011..1960790) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1960011..1960790) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1960816..1960831) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1960827) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1960843..1960852) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1960876..1961319) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1960876..1961319) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1960893) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1961382..1962104) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1961382..1962104) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1961663) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1962055..1962624) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1962055..1962624) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1962373..1962391) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1962389) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1962406..1962412) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1962643..1963389 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1962684..1964174) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1962684..1964174) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1964167..1965225) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1964167..1965225) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1964515..1964524 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1964535..1965325 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1964535 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1964537..1964556 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1965266..1965285) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965289) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965297..1965304) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1965303..1965309 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1965323..1965342 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1965327..1965396 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1965327 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1965376..1965383 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1965398..1965490 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1965398..1965417 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1965398 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1965491..1965739 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1965491..1965739 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1965723 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1965779..1966351) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1965779..1966351) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1965799) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1966343..1966650) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1966343..1966650) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1966352..1966456) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1966649..1966668) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966665) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1966682..1966688) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1966777..1966784 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1966795 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1966799..1966818 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1966848..1968425 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1966848..1968425 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1968407 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1968468..1969235) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1968468..1969235) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1968483) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1968737..1969349 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1969262..1969281) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1969275) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1969296..1969299) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1969309 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1969347..1970453) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1969347..1970453) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1969364) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1970389..1970973) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1970389..1970973) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1970767..1970772 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1970783 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1970787..1970791 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1970924..1970929 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1970941 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1970945..1970963 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1970981 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1971022..1971041) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1971026..1971133 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1971030) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971054..1971061) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1971089 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1971118..1971176) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1971149) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1971177..1972946) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1971177..1972946) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1971233) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1972943..1973665) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1972943..1973665) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1973666..1973745) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1973746..1974921) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1973746..1974921) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1974941..1976569) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1974941..1976569) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1976566..1977105) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1976566..1977105) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1977106..1977199) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1977200..1977934) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1977200..1977934) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1977943..1977962) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977966) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977977..1977981) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1978026..1978562) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1978026..1978562) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1978031..1978050) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978035) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1978065..1978072) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1978567..1979157) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1978567..1979157) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1979145..1980293) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1979145..1980293) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1980315..1980333) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1980322) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1980348..1980353) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1980416..1980955) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1980416..1980955) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1980429) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1980964..1980981) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1980979) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1980996..1981001) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981010..1981603) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1981010..1981603) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1981593..1982348) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1981593..1982348) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1982192..1982201 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1982214..1982233 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1982223 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1982394..1982413) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982409) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982427..1982434) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1982574..1982581 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1982592..1982611 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1982597 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1982629..1983153 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1982629..1983153 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1983167..1983541) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1983167..1983541) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1983183) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1983603..1983622) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983615) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983634..1983641) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983654..1984118) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1983654..1984118) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1983989..1983993 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1984007..1984011 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1984010 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1984151..1985347) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1984151..1985347) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1985362..1986009) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1985362..1986009) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1986020..1987105) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1986020..1987105) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1987106..1987234) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1987235..1987379) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1987235..1987379) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1987396..1987415) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987406) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1987430..1987437) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1987499..1987843) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1987499..1987843) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1987514) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1987875..1987893) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987888) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1987902..1987907 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1987908..1987914) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1987922..1988844 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1987922 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1987923..1987941 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1987929..1987944) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987932) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1987934..1988000) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1987957..1987966) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1987995..1988003) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988000) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988017..1988025) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1988078..1988632) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1988078..1988632) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1988088) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1988658..1988677) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988676) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1988678..1989077) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1988689..1988695) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1988899..1989135 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1988899..1989135 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1989078..1989284) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1989078..1989284) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1989317..1989336) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1989339) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1989393..1989647) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1989393..1989647) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1989527..1989536 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1989538..1989927) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1989538..1989927) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1989550..1990621 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1989550..1989569 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1989550 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1989905..1990108) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1989905..1990108) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1990517..1990633 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1990517..1990633 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1990584 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1990710..1990719 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1990732..1990751 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1990732 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1990774..1990986 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1990774..1990986 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1990980 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1991122) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1991122..1991553) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1991122..1991553) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1991554..1991640) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1991623..1991642) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991640) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1991656..1991661) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1991690..1991699 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1991709..1991806 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1991709 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1991712..1991727 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1991807..1992679 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1991807..1992679 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1992586 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1992652 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1992709..1994028) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1992709..1994028) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1992729) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1994029..1994093) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1994089..1994108) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994093) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1994123..1994130) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1994134..1994752) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1994134..1994752) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1994738,1994745) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1994739..1994744 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1994745..1994761) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1994762..1995931) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1994762..1995931) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1995960..1995971) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995975) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1995985..1995991) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1996077) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1996086..1996901) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1996086..1996901) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1996914..1998098) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1996914..1998098) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1998147..1998166) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998165) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1998167..1998258) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1998182..1998189) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998259..1999149) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1998259..1999149) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1999157..1999384) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1999157..1999384) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1999287..1999306) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999298) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999320..1999327) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1999377) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1999386..1999404) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1999414..1999432) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1999420..1999426) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1999427) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999449..1999454) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1999509) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1999509..1999958) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1999509..1999958) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1999982..2000001) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1999992) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1999994..2000070) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2000017..2000021) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2000071..2000715) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2000071..2000715) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2000746..2000764) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2000763) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2000779..2000784) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2000816..2001031) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2000816..2001031) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2000896) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2001131..2002450) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2001131..2002450) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2001138) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2002468..2003874) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2002468..2003874) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2003922..2003941) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003931) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2003933..2004014) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2003956..2003963) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2004015..2005442) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2004015..2005442) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2005487..2006476) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2005487..2006476) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2006477..2006556) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2006538..2006557) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006556) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2006558..2006878) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2006572..2006579) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2006597..2006604 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006617..2006636 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2006619 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2006658..2007008 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2006658..2007008 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2006880..2007016) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2006923) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2007017..2008180) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2007017..2008180) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2008177..2008734) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2008177..2008734) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2008664..2008764) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2008704) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2008748..2008753 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2008769..2008787 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2008771..2008785) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2008775 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2008782..2008956 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2008787..2008790) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2008790) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2008809..2008931 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2008809..2008931 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2008932..2008939 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2008953..2008972 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2008958 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2008994..2009914 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2008994..2009914 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2009903 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2009946..2010170) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2009946..2010170) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2010003) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2010193..2010212) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2010200) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2010227..2010234) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2010249..2010256 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2010271..2010290 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2010278 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2010332..2011249 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2010332..2011249 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2011224 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2011289..2011528) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2011289..2011528) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2011300) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2011541..2011864) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2011541..2011864) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2011607..2011626) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2011608) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2011640..2011647) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2011861..2012892) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2011861..2012892) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2011888..2011907) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2011895) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2011918..2011925) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2012885..2013229) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2012885..2013229) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2013239..2013709) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2013239..2013709) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2013710..2013786) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2013710 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2013761..2013780) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2013786) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2013788..2013894) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2013795..2013802) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2013895..2014233) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2013895..2014233) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2014230..2015468) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2014230..2015468) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2014392..2014393 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2014403 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2014458 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2015493..2015511) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2015502) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2015528..2015533) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2015573..2015576 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2015591..2015610 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2015600 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2015634..2015840 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2015634..2015840 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2016323..2016326 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2016341..2016360 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2016357 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2016389..2017621 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2016389..2017621 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2017468..2017830 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2017468..2017830 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2017647..2017826) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2017680) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2017827..2018213) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2017827..2018213) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2018217..2019176) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2018217..2019176) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2019177..2019247) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2019248..2020594) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2019248..2020594) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2020595..2020669) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2020670..2021449) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2020670..2021449) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2021455..2022414) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2021455..2022414) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2022436..2022455) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2022455) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2022470..2022477) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2022511..2022518 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2022532..2022818 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2022532 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2022534..2022553 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2022548..2022793 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2022548..2022793 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2022819..2023655 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2022819..2023655 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2023653 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2023696..2025339) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2023696..2025339) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2023708) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2025357..2025363 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2025370 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2025377..2025388 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2025395..2025414) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2025400) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2025446..2025453 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2025467..2025486 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2025469 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2025511..2026527 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2025511..2026527 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2026514 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2026576..2026585 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2026598..2026613 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026602 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2026637..2027398 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2026637..2027398 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2027306 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2027394 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2027426..2027626) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2027442..2027567) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2027442..2027567) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2027469) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2027560..2027592) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2027560..2027592) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2027620..2027639) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027626) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027652..2027659) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2027674..2028597) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2027674..2028597) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2028623..2028642) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028636) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2028656..2028661) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2028735..2028742 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2028756..2028775 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2028758..2028823 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2028758 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2028824..2030293 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2028824..2030293 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2030276 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2030301..2030340 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2030313,2030316) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2030321,2030322) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2030333,2030334) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2030342 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2030416..2031825) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2030416..2031825) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2030433) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2030506) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2031889..2031907) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2031891) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2031935..2033179) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2031935..2033179) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2033180..2033454) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2033200..2033207 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033221..2033240 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2033221 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2033252..2033539 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2033252..2033539 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2033436..2033455) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2033456) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2033471..2033474) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2033570..2034397 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2033570..2034397 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2034214 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2034390 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2034402..2035322) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2034445) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2034515..2034521 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2034535..2034553 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2034544 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2034577..2035305 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2034577..2035305 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2035346..2036461) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2035346..2036461) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2035367) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2036479..2038002) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2036479..2038002) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2037585..2037604) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037607) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2037619..2037623) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2037995..2038417) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2037995..2038417) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2038446..2038453 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2038467..2038486 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2038481..2038634 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2038481 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2038591 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2038619..2039149) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2038619..2039149) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2038636..2039271 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2039166..2039177) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2039173) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2039192..2039198) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2039201..2040169) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2039201..2040169) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2039217) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2040240..2040962) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2040240..2040962) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2040251) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2040955..2041614) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2040955..2041614) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2041615..2041694) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2041695..2042462) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2041695..2042462) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2042512..2042531) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042527) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042546..2042553) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2042730..2043167) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2042730..2043167) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2042739) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2043191..2043210) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2043212) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2043225..2043232) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2043265..2043271 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2043284 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2043286..2043304 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2043328..2044221 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2043328..2044221 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2044254..2044261 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044277..2044296 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2044285 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2044322..2045491 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2044322..2045491 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2045474 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2045564..2046400 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2045564..2046400 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2046398 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2046462) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2046462..2047736) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2046462..2047736) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2047759..2048742) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2047759..2048742) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2048756..2049748) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2048756..2049748) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2049770..2051194) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2049770..2051194) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2051215..2052306) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2051215..2052306) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2052325..2053419) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2052325..2053419) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2053431..2054330) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2053431..2054330) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2054366..2054385) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2054371) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2054373..2054454) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2054455..2056533) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2054455..2056533) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2056593..2056612) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056610) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2056620..2056627 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2056629..2056632) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2056641..2056660 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2056648 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2056686..2056922 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2056686..2056922 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2056913 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2056964..2057869) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2056964..2057869) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2056967) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2057887..2059305) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2057887..2059305) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2058182..2058201) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2058199) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2059320..2060438) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2059320..2060438) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2060472..2061611) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2060472..2061611) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2061639..2062502) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2061639..2062502) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2062527..2063708) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2062527..2063708) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2063288) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2063395..2063401) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2063398) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2063622..2063722) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2063662) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2063755..2063773) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063773) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063789..2063794) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2063835..2064566) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2063835..2064566) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2063842) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2064589..2064608) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064600) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2064623..2064626) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2064645..2065265) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2064645..2065265) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2065280..2065573) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2065280..2065573) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2065593..2065612) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065599) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2065627..2065634) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2065829..2065836 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2065850..2065869 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2065867..2066072 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2065867 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2065881..2066033 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2065881..2066033 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2066041..2066048 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066063..2066082 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066074 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2066106..2067224 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2066106..2067224 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2067209 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2067251..2067421) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2067294) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2067405..2067420) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067421) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2067423..2067551) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2067432..2067441) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2067550..2067569) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067573) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2067583..2067591) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2067683) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2067689..2068492) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2067689..2068492) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2068535..2068553) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068541) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2068543..2068695) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2068564..2068572) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2068691..2068710) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068703) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2068722..2068729) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2068737..2068738 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2068798..2070528) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2068798..2070528) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2068813) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2070565..2071014) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2070565..2071014) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2071015..2071100) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2071112..2071957) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2071112..2071957) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2071145) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2071954..2073855) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2071954..2073855) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2073063..2073069 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2073084..2073095 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2073092 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2073856..2073984) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2073979..2073998) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073984) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2074013..2074019) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2074030..2074920) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2074030..2074920) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2074910..2075164) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2074910..2075164) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2075161..2076507) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2075161..2076507) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2076508..2076644) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2076645..2077496) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2076645..2077496) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2077508..2077903) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2077508..2077903) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2077946..2077965) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2077965) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2077967..2078129) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2078167..2078574) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2078167..2078574) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2078174) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2078595..2079947) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2078595..2079947) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2079476..2079495) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2079483) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2079510..2079516) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2079959..2080438) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2079959..2080438) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2080497..2080516) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080508) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080530..2080537) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080594..2081250) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2080594..2081250) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2080601) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2081251..2081940) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2081251..2081940) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2081933..2082553) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2081933..2082553) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2082259..2082277) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082277) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2082293..2082298) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2082567..2083766) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2082567..2083766) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2083785..2084186) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2083785..2084186) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2084193..2084399) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2084193..2084399) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2084422..2084937) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2084422..2084937) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2084931..2085854) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2084931..2085854) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2085855..2085929) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2085930..2086211) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2085930..2086211) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2086231..2086249) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2086254) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2086265..2086270) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2086356..2086913) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2086356..2086913) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2086368) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2086938..2087999) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2086938..2087999) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2087996..2088442) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2087996..2088442) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2088491..2088510) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088507) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2088523..2088530) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2088529..2089065) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2088529..2089065) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2089078..2089089) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2089087) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2089103..2089109) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2089135..2089141 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2089154 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2089156..2089174 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2089211..2089214 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2089229..2089248 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2089240 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2089292..2090248 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2089292..2090248 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2090288..2090683 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2090288..2090683 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2090566..2090666 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2090626 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2090669 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2090680..2091555) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2090680..2091555) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2091582..2091600) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091599) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091616..2091621) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091681..2092109) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2091681..2092109) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2091708) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2092144..2092163) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092152) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092179..2092183) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092209..2093045) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2092209..2093045) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2093069..2093088) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093080) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2093082..2093626) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2093102..2093109) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2093126..2093131 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093145..2093164 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093145 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2093156..2093235 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2093236..2093616 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2093236..2093616 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2093552 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2093596 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2093651..2095117) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2093651..2095117) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2093671) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2095110..2096456) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2095110..2096456) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2096486..2097574) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2096486..2097574) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2097648..2097847) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2097648..2097847) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2097698) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2097848..2097918) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2097851..2097856 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2097872..2097890 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2097876 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2097886..2098015 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2097904..2097923) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2097918) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2097937..2097944) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2098016..2099689 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2098016..2099689 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2099710..2100504 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2099710..2100504 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2100040..2100041 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2100046 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2100528..2100531 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2100547..2100566 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2100548..2100686 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2100548 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2100687..2100860 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2100687..2100860 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2100845..2100849 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2100862..2100881 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2100862 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2100894..2101229 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2100894..2101229 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2101206 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2101296 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2101328) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2101345,2101352) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2101346..2101351 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2101421..2101427 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2101428 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2101441..2101452 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2101471..2101797 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2101471..2101797 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2101614..2101838) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2101657) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2101779 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2101839..2102018) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2101839..2102018) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2102037..2102055) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102052) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2102070..2102076) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2102089..2102463) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2102089..2102463) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2102464..2102847) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2102464..2102847) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2102873..2103220) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2102873..2103220) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2103204..2103635) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2103204..2103635) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2103625..2103921) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2103625..2103921) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2103935..2104906) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2103935..2104906) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2104959..2106029) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2104959..2106029) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2106047..2106066) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106063) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106080..2106087) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2106212..2106440) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2106253) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2106441..2107394) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2106441..2107394) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2107418..2107437) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107439) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107451..2107457) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2107477..2107483 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2107498..2107516 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2107516 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2107537..2108865 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2107537..2108865 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2108866..2109840 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2108918..2109754) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2108918..2109754) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2109755..2109939) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2109841..2109911 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2109841..2109911 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2109978..2110358) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2109978..2110358) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2109984) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2110387..2110405) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2110406) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2110420..2110426) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2110445..2110450 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2110466..2110484 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2110475 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2110525..2110532 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2110547 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2110548..2110567 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2110590..2110835 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2110590..2110835 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2110732 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2110821 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2110866..2111621 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2110875..2111510) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2110875..2111510) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2110900) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2111532..2111551) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111549) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2111565..2111572) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2111589..2111596 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2111611..2111630 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2111623 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2111643) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2111645..2111659) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2111667..2111671) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2111667..2111840 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2111667..2111840 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2111828 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2111872..2112186) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2111872..2112186) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2111873..2112940 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2111886) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2112189..2113250) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2112189..2113250) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2113312..2114442) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2113312..2114442) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2114450..2114468) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2114482) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2114484..2114489) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2114525..2116441) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2114525..2116441) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2114552) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2115557..2115563 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2115576..2116605 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2115576 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2115579..2115597 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2116442..2116508) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2116502..2116521) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116508) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2116536..2116543) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2116558..2117523) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2116558..2117523) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2117534..2117749) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2117534..2117749) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2117750..2117858) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2117859..2119382) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2117859..2119382) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2119400..2119419) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119413) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119434..2119441) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119472..2119645) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2119472..2119645) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2119499) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2119661..2119672) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119673) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119686..2119692) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119712..2120275) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2119712..2120275) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2120276..2120359) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2120360..2120509) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2120360..2120509) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2120406) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2120546..2120565) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2120556) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2120581..2120584) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2120593..2121672) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2120593..2121672) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2121669..2122139) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2121669..2122139) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2122084..2122092 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2122106..2122114 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2122107..2122280 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2122108 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2122175..2122194) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2122187) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2122206..2122213) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2122252..2122256 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2122272..2122291 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2122282 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2122319..2122672 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2122319..2122672 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2122669..2123133 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2122669..2123133 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2123119 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2123162..2123944) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2123162..2123944) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2123173) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2123955..2124764) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2123955..2124764) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2124785..2125669) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2124785..2125669) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2125669..2126598) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2125669..2126598) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2126667..2127569) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2126667..2127569) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2127624) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2127632..2127648) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2127659..2127661) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2127678,2127680) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2127724..2129874) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2127724..2129874) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2127734) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2128468..2128486) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128476) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2128502..2128508) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2129163..2129182) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2129180) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2129196..2129205) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2129924..2129943) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2129929) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2129959..2129963) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2129988..2131280) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2129988..2131280) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2131303..2131314) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131314) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2131328..2131334) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131387..2131995) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2131387..2131995) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2131402) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2132047..2132066) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2132058) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2132060..2132128) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2132081..2132088) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2132119..2132137) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2132128) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2132152..2132158) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2132174..2132656) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2132174..2132656) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2132657..2132949) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2132699..2132705 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2132720..2132739 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2132733 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2132766..2133533 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2132766..2133533 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2132947..2132965) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2132949) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2132951..2133887) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2132979..2132985) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2133534..2133964 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2133921 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2133932) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2133949..2134377) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2133949..2134377) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2134373..2134377 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2134387..2134401 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2134396 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2134400..2134419) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2134423) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2134434..2134441) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2134592..2134597 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2134613..2134631 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2134625 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2134654..2134953 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2134654..2134953 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2134966..2134973 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2134988..2135007 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2134999..2135075 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2134999 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2135076..2136209 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2135076..2136209 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2136190 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2136235..2136624) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2136235..2136624) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2136261) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2136655..2136666) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136659) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2136680..2136686) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2136699..2136706 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2136717..2136736 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136718 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2136757..2137338 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2136757..2137338 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2137336 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2137381..2137989 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2137381..2137818) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2137381..2137818) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2137385) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2137819..2137913) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2137909..2137928) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2137913) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2137943..2137950) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2137956..2138837) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2137956..2138837) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2138833..2138838 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2138854..2138872 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2138870 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2138875..2138894) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2138881) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2138883..2139210) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2138899..2138908 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2138915 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2138921..2138940 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2138953..2139207 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2138953..2139207 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2139194 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2139234..2140127) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2139234..2140127) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2139239..2140040 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2139255) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2140137..2141453) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2140137..2141453) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2141489..2141508) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141500) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2141524..2141528) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2141557..2141566 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2141578 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2141580..2141599 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2141622..2142365 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2141622..2142365 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2142347 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2142369..2142376 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2142390..2142409 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2142392..2142487 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2142392 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2142488..2143432 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2142488..2143432 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2143403 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2143455..2144576) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2143455..2144576) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2143480) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2144569..2145219) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2144569..2145219) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2145220..2145328) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2145316..2145335) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145328) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2145330..2145443) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2145351..2145355) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2145476..2145838) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2145476..2145838) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2145488) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2145834..2145838 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2145846..2145860 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2145867 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2145875..2145894) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145877) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2145879..2146000) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2145906..2145913) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2145989..2146008) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2145997..2146016 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146000) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2146002..2146141) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2146003..2146107 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2146003 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146022..2146028) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2146071..2146078 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2146092..2146111 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2146109..2148258 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2146109 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2146167..2147282) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2146167..2147282) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2146186) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2147283..2147480) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2147481..2149292) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2147481..2149292) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2148887..2148893 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2148903 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2148905..2148924 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2148932..2149228 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2148932..2149228 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2149326..2149820) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2149326..2149820) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2149793..2149811) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2149804) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2149821..2149934) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2149823..2149831) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2149829..2149834 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2149850..2149868 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2149865 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2149919..2149937) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2149934) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2149936..2150013) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2149953..2149958) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2149979..2149998) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2150013) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2150014..2150017) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2150074..2150886) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2150074..2150886) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2150912..2151550) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2150912..2151550) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2151551..2151682) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2151676..2151695) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2151683..2153722) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2151683..2153722) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2151685) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2151710..2151717) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2151729) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2151795) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2153715..2154602) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2153715..2154602) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2154685..2154859) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2154685..2154859) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2154719) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2154834..2154839 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2154855..2154873 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2154863..2154882) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2154865..2156277 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2154865 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2154875) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2154897..2154904) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2154899..2155666) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2154899..2155666) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2155703..2155846) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2155703..2155846) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2155847..2155993) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2155994..2156899) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2155994..2156899) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2156880..2157290) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2156880..2157290) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2157328..2157347) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2157339) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2157341..2157408) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2157362..2157365) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2157409..2157780) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2157409..2157780) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2157761..2158234) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2157761..2158234) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2158235..2160370) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2158235..2160370) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2160214..2160219 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2160234 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2160235..2160253 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2160449..2161408) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2160449..2161408) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2160464) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2161405..2162601) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2161405..2162601) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2161472..2161491) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2161477) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2161505..2161512) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2161552..2161570) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2161564) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2161585..2161591) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2161779) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2161793..2161804) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2161819..2161825) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2162620..2162901) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2162620..2162901) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2162958..2163377) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2162958..2163377) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2162972) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2163402..2164397) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2163402..2164397) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2164419..2165732) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2164419..2165732) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2165768..2165783) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2165785) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2165796..2165805) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2165863..2166309) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2165863..2166309) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2165876) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2166074) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2166324..2166497) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2166324..2166497) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2166433..2166437 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2166438 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2166558..2166577) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2166573) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2166591..2166598) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2166616..2166621 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2166636 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2166637..2166655 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2166670..2167593 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2166670..2167593 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2167630..2168985) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2167630..2168985) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2167636) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2168985..2169755) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2168985..2169755) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2169778..2170713) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2169778..2170713) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2170738..2171865) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2170738..2171865) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2171782..2171785 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2171793 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2171866..2172043) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2171905..2171995 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2171905..2171995 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2172065..2173900) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2172065..2173900) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2172088) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2173924..2174487) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2173924..2174487) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2174488..2174558) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2174559..2175590) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2174559..2175590) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2175631..2175650) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175644) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175665..2175672) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2175671..2176810) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2175671..2176810) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2176683..2176694) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2176687) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2176708..2176714) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2176863..2178701) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2176863..2178701) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2176885) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2178736..2178755) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178753) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2178771..2178775) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2178835..2179173) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2178835..2179173) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2178841) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2179190..2180395) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2179190..2180395) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2180415..2180433) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2180427) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2180449..2180454) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2180458..2181564) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2180458..2181564) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2181592..2181603) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181599) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2181618..2181624) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2181663..2181666 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2181679 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2181682..2181701 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2181693..2181767 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2181768..2182034 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2181768..2182034 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2182023 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2182049..2183092) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2182049..2183092) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2182094) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2183121..2183140) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2183132..2183281) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2183132..2183281) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2183133) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2183154..2183158) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2183156..2183495) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2183199) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2183268..2183274 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2183288..2183307 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2183289 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2183322..2183456 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2183322..2183456 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2183450 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2183496..2185826) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2183496..2185826) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2183513..2183532) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183529) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2183546..2183555) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2185830..2186399) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2185830..2186399) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2186426..2186445) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2186436) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2186460..2186467) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2186466..2187083) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2186466..2187083) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2187104..2187109 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2187121 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2187125..2187143 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2187144..2187158) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187146) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2187148..2187995) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2187167..2187171) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2187167..2187988 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2187167..2187988 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2187983..2188002) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2187989..2188069 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2187996) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2188016..2188023) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2188029 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2188054..2188797) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2188054..2188797) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2188084) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2188794..2189150) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2188794..2189150) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2189168..2189728) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2189168..2189728) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2189718..2190287) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2189718..2190287) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2190299..2190589) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2190299..2190589) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2190583..2191425) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2190583..2191425) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2191417 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2191443..2192543) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2191443..2192543) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2192547..2193065) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2192547..2193065) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2192975..2192992) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2192989) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193008..2193011) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2193066..2193627) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2193099) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2193290..2193297 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2193308..2193408 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2193308..2193327 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2193308 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2193358..2193616) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2193358..2193616) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2193409..2193567 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2193409..2193567 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2193568..2193814 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2193615..2193634) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2193626) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193650..2193654) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2193678..2193825) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2193715) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2193771 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2193816..>2193893 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2193820..2193839) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2193825) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193852..2193861) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2193893,2193895) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2193894 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2193895..2194337 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2193908..2194324) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2193908..2194324) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2194370..2195668) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2194370..2195668) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2195655..2196350) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2195655..2196350) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2196416..2196433) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2196425) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2196511..2196517 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2196524..2196542 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2196539 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2196618..2197835 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2196618..2197835 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2197077..2197084 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197099..2197118 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2197115 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2197754..2198002 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2197754..2198002 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2197931..2198978) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2198347..2198904 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2198347..2198904 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2198905..2199027 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2198980..2199394) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2199023) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2199395..2199919) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2199395..2199919) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2199767..2199774 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2199785..2199804 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2199799 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2199920..2200007) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2200002..2200021) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2200007) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2200009..>2200145) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2200036..2200043) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2200145,2200152) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2200146..2200151 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2200204..2200734) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2200204..2200734) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2200780..2200799) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2200803) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2200813..2200820) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2200869..2201849 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2200869..2201849 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2202123..2203439) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2202123..2203439) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2203440..2203553) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2203554..2204423) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2203554..2204423) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2204446..2204465) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204463) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2204480..2204485) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2204530..2204531) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204538) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2204568..2204569) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2204568..2205671 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2204568..2205671 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2205561..2205580 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2205567 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2205918) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2205944..2206777) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2205944..2206777) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2206807..2206826) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2206816) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2206982..2206986 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2206997..2207219 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2206997 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2207001..2207020 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2207220..2207483 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2207220..2207483 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2207471 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2207620..2208435 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2207620..2208435 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2208770..2208842) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2208813) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2208843..2209199) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2208843..2209199) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2209252..2209611) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2209252..2209611) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2209704..2209723) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2209714) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2209883..2209984) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2209883..2209984) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2210024..2210126) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2210066) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2210127..2210513) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2210127..2210513) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2210555..2210571) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2210571) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2210704..2210710 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2210725..2210736 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2210725 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2210762..2211007 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2210762..2211007 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2211025..2211393 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2211025..2211393 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2211412..2212548 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2211412..2212548 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2212567..2212764 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2212567..2212764 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2212780..2213079 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2212780..2213079 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2213070 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2213342..2213764) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2213342..2213764) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2213762..2213765 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2213781..2213800 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2213796..2213946 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2213796 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2213799..2213818) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213806) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2213832..2213839) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2213915..2213934) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2213923) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2213947..2214141 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2213947..2214141 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2213949..2213956) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2214159..2214166 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2214182..2214201 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2214186 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2214187..2214271 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2214272..2215321 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2214272..2215321 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2215389..2215396 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2215411..2215430 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2215424 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2215452..2215961 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2215452..2215961 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2215930 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2215975..2217080 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2216003..2218036) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2216003..2218036) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2216028) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2217945..2218112) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2217945..2218112) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2218037..2218192) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2218193..2219020) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2218193..2219020) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2219041..2219850) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2219041..2219850) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2219867..2220355) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2219867..2220355) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2220355..2220795) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2220355..2220795) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2220792 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2220832..2220850) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2220836) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2220985..2223792) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2220985..2223792) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2224008..2224027) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2224014) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2224339..2224479 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2224339..2224479 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2224460..2224479 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2224470 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2224518..2225906 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2224518..2225906 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2225895 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2225928..2226001) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2225970) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2226002..2226634) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2226002..2226634) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2226058) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2226688..2226707) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226699) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2226713..2226719 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2226722..2226729) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2226733..2226752 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2226738 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2226787..2227614 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2226787..2227614 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2227610 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2227727..2227736 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2227749..2227764 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2227754 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2227810..2228310 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2227810..2228310 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2228310..2229167 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2228310..2229167 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2229185..2229196) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2229204) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2229211..2229217) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2229278..2231182 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2229278..2231182 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2231263..2231269 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2231285..2231303 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2231291 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2231316..2231606 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2231316..2231606 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2231607..2231722 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2231704..2231711 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2231724..2231849 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2231724 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2231725..2231743 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2231743..2231843 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2231743..2231843 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2231806 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2231850..2235014) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2231850..2235014) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2231866) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2233000..2233009 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233023..2233042 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2233044 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2235030..2235614) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2235030..2235614) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2235837..2236379) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2235837..2236379) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2236380..2236465) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2236463..2236478) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2236465) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236491..2236500) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2236534..2236750) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2236568..2236726) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2236568..2236726) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2236577) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2236748..2236767) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2236750) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2236752..2236882) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2236781..2236790) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2236883..2237032) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2236883..2237032) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2237026 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2237033..2237123) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2237125..2237344) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2237168) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2237290 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2237323..2237342) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237344) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2237346..2237421) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2237357..2237364) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237422..2238222) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2237422..2238222) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2238291..2238444) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2238334) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2238435..2238454) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2238444) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2238469..2238475) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2238485..2238853) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2238485..2238853) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2238854..2238950) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2238936..2238955) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2238940..2238943 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2238956) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2238959..2238978 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2238961 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2238962..2239168 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2238971..2238975) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2239169..2242111 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2239169..2242111 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2242130..2242612 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2242130..2242612 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2242592 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2242648..2242878) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2242648..2242878) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2242668) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2242879..2242960) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2242961..2244100) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2242961..2244100) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2244102..2245025) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2244102..2245025) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2245018) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2245026..2245089) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2245090..2245785) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2245090..2245785) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2245525..2245544) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245543) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2245557..2245566) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2245806..2246447) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2245806..2246447) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2246014..2246033) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246033) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246050..2246053) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2246499..2246508 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2246505..2246524) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246511) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2246521..2246540 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2246530..2246594 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2246530 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246540..2246543) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2246575..2246582 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2246596 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2246598..2246615 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2246640..2246843 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2246640..2246843 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2246850 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2246880..2247581) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2246880..2247581) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2246892) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2247646..2249400) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2247646..2249400) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2247674..2247693) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2247684) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2248715..2248730) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248718) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2248743..2248752) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2248946..2248964) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248960) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2248979..2248986 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2248979..2248984) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2249001..2249020 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2249006 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2249454..2249927) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2249454..2249927) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2249461) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2249928..2250060) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2250042..2250061) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2250060) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2250062..2250170) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2250075..2250082) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2250163..2250182) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2250170) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2250178..2250813) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2250178..2250813) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2250198..2250202) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2250308..2250313 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2250329..2250347 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2250336 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2250820..2252088) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2250820..2252088) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2252107..2253036) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2252107..2253036) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2253042..2253695) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2253042..2253695) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2253696..2253800) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2253782..2253801) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253800) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2253817..2253821) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2253847..2254929) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2253847..2254929) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2253881) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2254945..2254964) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254965) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2254979..2254982) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2255055) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2255060..2255341) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2255060..2255341) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2255120) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2255359..2255775) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2255359..2255775) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2255607..2255625) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255626) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255641..2255646) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255783..2256049) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2255783..2256049) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2255937..2255945 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2255960..2255979 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2255968..2257157 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2255968 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2256050..2256110) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2256104..2256123) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2256110) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2256134..2258770) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2256134..2258770) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2256137..2256144) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2258536..2258554) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258552) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2258568..2258575) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2258771..2258849) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2258850..2259057) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2258850..2259057) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2259065..2259084) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259080) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2259099..2259106) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2259101..2260162) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2259101..2260162) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2260071..2260076 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2260082..2260317 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2260083 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2260092..2260110 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2260179..2260190) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260180) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260204..2260210) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2260318..2261046 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2260318..2261046 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2260774) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2261068..2261889 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2261068..2261889 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2261950..2262600 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2261950..2262600 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2262617..2263273 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2262617..2263273 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2263272 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2263308..2263439) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2263308..2263439) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2263326) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2263461..2263652) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2263461..2263652) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2263664..2264188) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2263664..2264188) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2263775) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2263779..2263790) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2263805..2263811) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2264159..2264170) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264165) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264185..2264191) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2264246..2266642) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2264246..2266642) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2264272) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2264492..2264498 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2264506 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2264513..2264524 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2264526..2264875 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2264627) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2266667..2267287) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2266667..2267287) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2267373..2268488) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2267373..2268488) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2267374) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2268519..2269658) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2268519..2269658) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2269225..2269244) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269237) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269258..2269265) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269677..2270093) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2269677..2270093) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2270094..2270191) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2270176..2270195) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270191) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2270211..2270214) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2270239..2270246 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2270260..2270279 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2270268 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2270296..2271561 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2270296..2271561 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2271560 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2271603..2272367) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2271603..2272367) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2271621) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2272451..2272651) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2272451..2272651) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2272469) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2272638 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2272639..2272648 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2272649..2272668) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272660) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2272681..2272688) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2272703..2274481) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2272703..2274481) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2274495..2275769) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2274495..2275769) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2275859..2276091) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2275859..2276091) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2275889) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2276101..2276104 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2276115..2276134) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2276119..2276138 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2276121..2276405 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2276121 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2276134) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276149..2276156) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276151..2276321) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2276151..2276321) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2276352..2276363) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2276369) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2276378..2276384) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2276381..2276388 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2276402..2276420 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2276407 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2276454..2278010 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2276454..2278010 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2277989 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2278037..2278435) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2278037..2278435) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2278045) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2278489..2280693) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2278489..2280693) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2280722..2280741) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280729) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2280731..2280821) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2280756..2280763) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2280785 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2280861..2281373) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2280861..2281373) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2280866) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2281379..2283739) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2281379..2283739) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2281843..2281862) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2281851) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2281876..2281885) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2283753..2283772) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2283764) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2283787..2283793) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2283806..2284129) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2283806..2284129) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2284150..2284168) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2284161) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2284183..2284189) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2284205..2284702) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2284205..2284702) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2284703..2284778) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2284772..2284791) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2284778) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2284805..2284812) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2284860..2287073) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2284860..2287073) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2284865) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2286632..2286637 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2286651..2286670 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2286659 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2287112..2287408) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2287112..2287408) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2287319 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2287409..2287487) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2287449..2287454 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2287471..2287489 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2287473..2287492) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2287473 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2287487) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2287489..2288407) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2287507..2287510) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2287524..2289080 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2287524..2289080 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2288393..2288411) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2288407) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2288423..2288431) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2289081..2289845 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2289084..2289740) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2289084..2289740) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2289759..2289770) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289771) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2289784..2289790) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2289823..2289828 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289844..2289862 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289847 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2289875..2290327 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2289875..2290327 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2290311 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2290366) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2290384..2290650) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2290384..2290650) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2290687..2291832) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2290687..2291832) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2290739) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2290783) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2290785..2290804) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2290819..2290824) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2291859..2292887) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2291859..2292887) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2292917..2293117) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2292917..2293117) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2293110..2294114) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2293110..2294114) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2294125..2294730) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2294125..2294730) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2294749..2294768) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294765) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2294767..2294868) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2294779..2294785) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294869..2295381) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2294869..2295381) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2295410..2295421) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2295425) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2295429..2296736) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2295429..2296736) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2295436..2295442) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2296690) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2296760..2296778) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2296775) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2296793..2296799) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2296807..2297832) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2296807..2297832) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2297869..2297888) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2297889) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2297903..2297910) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2297958..2297965 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2297979..2297998 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2297987 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2298019..2298024 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2298033 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2298040..2298058 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2298070..2298717 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2298070..2298717 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2298392..2298725) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2298696 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2298727..2298924) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2298763..2298885) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2298763..2298885) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2298770) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2298933) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2298934..2298951) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2298958..2298965) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2298970..2299260 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2298970..2299260 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2298981..2299000 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2298981..2299128 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2298981 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2299267..2299407 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2299267..2299407 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2299396 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2299456..2299462 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2299470..2299570 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2299477..2299495 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2299478 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2299530 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2299571..2301025 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2299571..2301025 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2301026 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2301066..2301788) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2301066..2301788) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2301071..2301492 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2301082) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2301811..2301830) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301828) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2301844..2301851) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2301891..2302487) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2301891..2302487) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2301906) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2302530..2302541) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302532) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2302534..2302598) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2302556..2302562) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2302635..2303798) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2302635..2303798) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2302643) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2303799..2303874) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2303850..2303868) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303874) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2303884..2303889) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2303915..2305021) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2303915..2305021) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2304597..2304615) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2304622) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2304631..2304636) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2304933 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2304934..2304937 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2305008..2305877) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2305008..2305877) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2305102 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2305831..2307426) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2305831..2307426) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2307454..2307461 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2307454..2307473) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2307475 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2307477..2307496 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2307478) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2307488..2307495) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2307529..2308716 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2307529..2308716 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2307530..2307549) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2307548) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2307564..2307573) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2308431..2308436 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2308445 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2308447..2308466 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2308676..2309218 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2308676..2309218 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2309201 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2309243..2310100) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2309243..2310100) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2309246..2309955 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2309263) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2310117..2310560) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2310117..2310560) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2310621..2311907) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2310621..2311907) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2311941..2312519) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2311941..2312519) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2312520..2312585) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2312570..2312589) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312585) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2312587..2312804) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2312597..2312719 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2312597..2312719 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2312603..2312610) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2312840..2313124) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2312840..2313124) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2312849) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2313137..2313475) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2313137..2313475) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2313478..2313786) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2313478..2313786) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2313800..2313875) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2313800..2313875) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2313887..2313906) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2313907) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2313920..2313927) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2313933..2314799) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2313933..2314799) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2314792..2315586) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2314792..2315586) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2315589 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2315595..2315695 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2315610..2315628) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2315621) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2315644..2315649) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2315655 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2315698 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2315733) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2315736..2316542) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2315736..2316542) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2316544..2317224) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2316544..2317224) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2317277..2317795) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2317277..2317795) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2317792..2318664) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2317792..2318664) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2318695..2319708) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2318695..2319708) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2319749) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2319761..2319779) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2319800..2320495) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2319800..2320495) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2320532..2321101) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2320532..2321101) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2320953..2320968) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320962) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2320981..2320990) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2321140..2321159) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2321156) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2321173..2321179) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2321252) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2321254..2322252) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2321254..2322252) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2322299..2322318) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322307) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322330..2322337) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2322375) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2322386..2323132) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2322386..2323132) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2323160..2323179) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323167) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323194..2323201) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2323272..2324564) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2323272..2324564) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2323277) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2324565..2324623) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2324624..2327266) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2324624..2327266) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2327267..2327325) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2327326..2327548) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2327326..2327548) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2327369) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2327577..2327596) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327589) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2327591..2327699) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2327611..2327616) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2327653..2327662 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327675..2327694 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2327676 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2327692..2327706) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327699) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2327714..2327718) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2327714..2327905 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2327714..2327905 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2327924..2328949) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2327924..2328949) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2327954) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2328982..2330709) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2328982..2330709) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2330311..2330314 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2330330..2330349 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2330336 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2330705..2330709 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2330718..2330732 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2330732 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2330747..2330765) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2330763) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2330781..2330786) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2330840..2332132) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2330840..2332132) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2330857) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2332162..2333136) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2332162..2333136) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2333133..2333921) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2333133..2333921) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2333911..2334855) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2333911..2334855) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2334888..2335718) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2334888..2335718) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2335726..2337093) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2335726..2337093) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2337157..2337176) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2337163) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2337165..2337254) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2337214..2337233 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2337222 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2337251..2337270) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337254) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2337256..2337672) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2337281..2337289) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2337323..2337820 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2337323..2337820 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2337656..2337674) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337672) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2337674..2337804) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2337690..2337696) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2337784..2337795) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2337804) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2337810..2337816) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2337842..2338429) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2337842..2338429) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2337870) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2338426..2340750) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2338426..2340750) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2340751..2340862) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2340847..2340866) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340862) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340880..2340887) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2340931..2342589) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2340931..2342589) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2340950) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2342633..2342651) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342644) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2342667..2342672) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2342741..2344003) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2342741..2344003) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2342751) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2344004..2344093) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2344081..2344100) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344093) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2344095..2344226) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2344112..2344119) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2344271) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2344275..2345549) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2344275..2345549) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2345550..2345739) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2345726..2345745) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2345739) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2345760..2345764) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2345777..2346781) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2345777..2346781) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2346806..2346825) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2346824) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2346837..2346844) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2346900..2347499) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2346900..2347499) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2346921) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2347512..2348930) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2347512..2348930) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2348819..2348823 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2348838..2348842 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2348838 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2348980..2350077) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2348980..2350077) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2350098..2351654) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2350098..2351654) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2350494..2350497 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2350510..2352951 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2350510 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2350512..2350531 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2351641..2352669) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2351641..2352669) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2352693..2353211) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2352693..2353211) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2352932..2352935 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2352951..2352955 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2352953 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2353208..2354932) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2353208..2354932) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2354933..2355053) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2355054..2355300) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2355054..2355300) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2355097) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2355301..2355427) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2355409..2355428) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2355427) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2355429..2355559) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2355443..2355450) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2355554..2355573) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2355563) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2355587..2355590) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2355685..2355694 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2355708..2355727 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2355710 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2355748..2356083 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2355748..2356083 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2356077 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2356164..2356171 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2356185..2356204 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2356187..2356251 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2356187 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2356252..2356707 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2356252..2356707 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2356815..2356821 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2356835..2356853 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2356842 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2356891..2357712 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2356891..2357712 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2357705 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2357769 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2357776..2357849) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2357776..2357849) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2357810) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2357886..2357905) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357889) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2357919..2357926) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2357980..2358489) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2357980..2358489) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2357997) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2358505..2359101) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2358505..2359101) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2359114..2359851) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2359114..2359851) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2359933..2359952) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359949) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2359962..2361062) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2359962..2361062) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2359967..2359972) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2359979) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2361085..2361103) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361101) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2361118..2361123) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2361177..2361995) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2361177..2361995) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2361189) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2362003..2362443) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2362003..2362443) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2362486..2362505) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2362495) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2362497..2362639) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2362521..2362525) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2362684) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2362687..2362911) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2362687..2362911) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2362960 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2362962..2362980 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2362969..2362988) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2362989) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2363002..2363011) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2363027..2363470) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2363027..2363470) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2363531..2364292) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2363531..2364292) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2363539) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2364295..2366055) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2364295..2366055) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2366089..2366697) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2366089..2366697) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2366467..2366474 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2366487..2366506 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2366489 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2366698..2366793) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2366783..2366802) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2366793) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2366795..2367416) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2366817..2366824) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2366932..2366936 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2366946..2367046 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2366953..2366972 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2366962 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2366990..2367436 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2366990..2367436 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2367006 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2367424 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2367462) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2367480..2368706) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2367480..2367971) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2367480..2368706) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2367480..2367971) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2368820) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2368832..2369011) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2368832..2369011) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2368864) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2369036..2369055) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2369043) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2369068..2369075) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2369076..2370848) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2369076..2370848) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2370875..2370894) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2370889) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2370908..2370915) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2370978) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2370984..2371298) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2370984..2371298) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2371324..2371343) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371338) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2371340..2371549) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2371359..2371361) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371443..2371553) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2371443..2371553) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2371539..2371557) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2371549) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2371572..2371578) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2371621..2373108) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2371621..2373108) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2373109..2373221) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2373202..2373221) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2373221) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2373236..2373243) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2373325..2374302) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2373325..2374302) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2373333) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2374338..2375111) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2374338..2375111) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2375126..2375902) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2375126..2375902) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2375191 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2375917..2376501) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2375917..2376501) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2376543..2376562) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376543) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376575..2376582) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2376606..2378288) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2376606..2378288) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2378317..2378336) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2378325) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2378413) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2378477..2378881) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2378477..2378881) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2378479) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2378896..2381253) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2378896..2381253) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2381274..2382986) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2381274..2382986) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2382987..2383059) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2383060..2383593) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2383060..2383593) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2383600..2383857) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2383600..2383857) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2383884..2383903) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383900) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2383915..2383922) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2383940..2383959 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2383947 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2383991..2384932 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2383991..2384932 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2384664..2384683) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384679) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384697..2384704) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2384915 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2384947) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2384968..2387382) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2384968..2387382) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2384991) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2387398..2388432) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2387398..2388432) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2388433..2388753) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2388514..2388720 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2388514..2388720 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2388743..2389007 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2388743 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2388748..2388767) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2388750..2388764 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2388753) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2388782..2388785) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2388787..2389533) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2388787..2389533) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2389560..2389579) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2389566..2389572 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2389573) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2389586..2389597 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2389593..2389599) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2389600 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2389652..2389867 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2389652..2389867 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2389849..2391261) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2389878..2389885 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389901..2389920 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389909 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2389936..2391042 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2389936..2391042 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2391078..2391081 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2391097..2391116 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2391101 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2391145..2392557 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2391145..2392557 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2391247..2391266) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391261) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391279..2391288) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2392554..2393888 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2392554..2393888 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2393587,2393589) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2393886 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2393925) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2393927..2394169) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2393927..2394169) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2394170..2394341) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2394229..2394399) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2394229..2394399) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2394342..2396138) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2394342..2396138) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2394444..2394462) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2394462) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2394474..2394482) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2396135 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2396163..2396182) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396173) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2396197..2396203) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2396233..2396289) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2396257) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2396290..2397792) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2396290..2397792) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2397663) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2397767..2397867) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2397807) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2397811..2398656) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2397811..2398656) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2398657..2399598) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2398657..2399598) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2399634..2400935) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2399634..2400935) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2400966..2402150) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2400966..2402150) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2402147..2402965) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2402147..2402965) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2402943..2403632) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2402943..2403632) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2403649..2405331) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2403649..2405331) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2405345..2406835) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2405345..2406835) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2406928..2406947) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406935) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2406937..2407012) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2406962..2406969) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2407013..2407984) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2407013..2407984) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2407985..2408113) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2408098..2408117) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2408113) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2408132..2408135) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2408181..2409266) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2408181..2409266) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2408195) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2409292..2409311) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2409315) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2409326..2409333) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2409384..2409393 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2409399 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2409405..2409420 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2409450..2409842 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2409450..2409842 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2409813 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2409858..2410164 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2409858..2410127) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2409858..2410127) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2409874) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2410043) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2410121 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2410184..2410543) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2410184..2410543) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2410197) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2410575..2410775) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2410575..2410775) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2410788..2411309) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2410788..2411309) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2411371..2411510) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2411371..2411510) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2411507..2411526) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411517) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2411519..2411583) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2411540..2411547) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2411565..2411584) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411583) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2411600..2411604) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2411702..2411709 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2411723..2411741 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2411723 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2411755..2412420 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2411755..2412420 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2412398 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2412452..2413147) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2412452..2413147) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2412474) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2412518) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2413169..2413609) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2413169..2413609) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2413631..2413650) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413650) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2413666..2413669) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2413743..2414468) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2413743..2414468) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2413772) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2414446..2416227) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2414446..2416227) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2416311..2416314 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2416323..2416342) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2416328) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2416329..2416348 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2416336 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2416394..2417176 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2416394..2417176 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2417160 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2417210) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2417217..2419148) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2417217..2419148) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2419192..2419439) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2419192..2419439) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2419195..2419204) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2419195) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2419250) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2419450..2419469) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2419463) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2419465..2419545) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2419485..2419489) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2419546..2420391) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2419546..2420391) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2420411..2420429) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2420417) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2420445..2420450) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2420470..2421111) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2420470..2421111) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2421145..2422080) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2421145..2422080) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2422108..2423526) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2422108..2423526) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2423555..2423574) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423563) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2423589..2423592) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2423641..2424099) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2423641..2424099) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2423660) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2424100..2424247) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2424238..2424257) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2424247) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2424249..2424327) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2424272..2424275) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2424372) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2424373..2424753) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2424373..2424753) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2424754..2424908) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2424888..2424907) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2424895 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2424896..2424915 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2424908) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2424922..2424928) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2424986..2424997) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2424992..2426014) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2424992..2426014) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2424993) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2425012..2425018) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2426058..2426077) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426089) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2426090..2426097) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2426220..2426600) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2426220..2426600) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2426244) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2426601..2426731) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2426656..2426660 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2426676..2426695 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2426677..2426783 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2426677 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2426721..2426740) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426731) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2426755..2426762) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2426784..2427974 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2426784..2427974 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2427606..2427624) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2427622) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2427640..2427645) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2427998..2428840 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2427998..2428840 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2428613..2428618 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2428634..2428652 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2428635 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2428833 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2428873) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2428882..2429475) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2428882..2429475) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2429491..2430123) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2429491..2430123) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2430124..2430288) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2430289..2431119) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2430289..2431119) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2431142..2433784) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2431142..2433784) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2433839..2433858) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433848) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433872..2433879) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2433908..2434027) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2433951) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2434028..2435767) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2434028..2435767) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2435760..2436482) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2435760..2436482) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2436550..2436569) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436560) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2436562..2436662) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2436583..2436589) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436694..2437632) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2436694..2437632) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2436707) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2437676..2438947) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2437676..2438947) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2438732..2438751) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2438744) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2438948..2439030) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2439030) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2439032..2439110) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2439032..2439051) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2439067..2439071) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2439111..2440229) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2439111..2440229) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2439724 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2440071..2440074 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2440079 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2440208 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2440230..2440436) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2440404..2440416 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2440415 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2440422..2440441) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440436) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2440456..2440460) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2440556) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2440563..2441027) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2440563..2441027) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2441040..2441059) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2441054) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2441056..2442241) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2441056..2441061 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2441072..2441080) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2441076..2441094 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2441082 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2441124..2442239 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2441124..2442239 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2442210 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2442272..2442655) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2442272..2442655) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2442286) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2442656..2442747) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2442748..2444505) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2442748..2444505) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2444548..2445507) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2444548..2445507) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2445508..2445609) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2445598..2445617) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445609) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2445633..2445637) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2445691..2446668) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2445691..2446668) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2445718) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2446653..2447525) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2446653..2447525) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2447487..2447492 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2447508..2447526 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2447512..2448686 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2447512 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2447526..2447609) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2447598..2447617) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447609) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2447611..2447763) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2447633..2447637) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2447765..2447859) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2447808) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2447860..2449092) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2447860..2449092) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2449093..2449209) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2449197..2449216) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2449209) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2449229..2452576) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2449229..2452576) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2449230..2449237) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2450241..2450250 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2450262..2450277 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2450262 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2450450..2450469) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450469) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450483..2450490) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2452607..2452626) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2452625) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2452640..2452647) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2452665..2452670 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2452682 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2452686..2452704 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2452716..2453057 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2452716..2453057 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2453054..2453557 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2453054..2453557 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2453590..2453593 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2453608..2453627 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2453608 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2453659..2453850 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2453659..2453850 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2453660) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2453826 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2453868..2454809) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2453868..2454809) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2453871..2454242 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2453903) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2454211..2454220 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2454234..2454253 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2454244..2454638 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2454244 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2454600..2454606 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2454622..2454641 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2454640..2454939 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2454640 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2454828..2454847) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2454844) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2454846..2455260) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2454862..2454865) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2454940..2455242 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2454940..2455242 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2455243..2457038 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2455261..2456580) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2455261..2456580) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2456606..2456625) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456627) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2456640..2456645) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2456756..2457658) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2456756..2457658) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2457677..2458927) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2457677..2458927) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2458945..2459637) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2458945..2459637) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2459684..2461012) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2459684..2461012) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2461009..2461290) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2461009..2461290) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2461305..2462309) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2461305..2462309) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2462306..2463085) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2462306..2463085) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2463082..2463789) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2463082..2463789) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2463819..2464538) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2463819..2464538) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2464364..2464371 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2464386..2464405 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2464386 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2464560..2465372) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2464560..2465372) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2465386..2466195) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2465386..2466195) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2466209..2466745) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2466209..2466745) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2466782..2466789 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2466800..2466819) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2466803..2466822 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2466806..2466897 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2466806 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2466816) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2466833..2466840) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2466898..2467824 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2466898..2467824 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2467300..2467829) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2467874) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2467875..2468558) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2467875..2468558) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2468559..2468620) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2468621..2469388) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2468621..2469388) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2469433..2469452) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469455) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469468..2469470) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469515..2469751) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2469515..2469751) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2469600 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2469620) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2469711..2471096) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2469711..2471096) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2471093..2472304) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2471093..2472304) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2472305..2472382) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2472375..2472394) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472381) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472409..2472416) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472474..2472986) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2472474..2472986) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2472492) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2473012..2473031) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473020) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473045..2473052) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2473071..2474258) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2473071..2474258) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2473086) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2474259..2474363) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2474348..2474367) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474363) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2474365..2474494) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2474383..2474387) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474431..2474634) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2474431..2474634) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2474492..2474503) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474494) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474518..2474524) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474606..2475595) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2474606..2475595) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2474624) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2475656..2476159) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2475656..2476159) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2475662) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2475876..2475976 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2475936 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2476155 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2476182..2476201) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476198) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476215..2476222) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2476269..2476724) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2476269..2476724) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2476297) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2476738..2477418) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2476738..2477418) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2476830) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2476837..2476848) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2476863..2476869) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2477156) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2477431..2477449) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2477445) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2477464..2477469) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2477493..2477987) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2477493..2477987) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2477508) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2478000..2479007) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2478000..2479007) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2479031..2479046) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479048) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2479050..2479129) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2479058..2479067) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2479107..2479126 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2479117 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2479122..2479141) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2479126..2479192 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2479129) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2479157..2479161) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2479193..2479996 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2479193..2479996 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2479926 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2479984 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2480028..2481617) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2480028..2481617) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2480037) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2481637..2483226) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2481637..2483226) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2483272..2483289) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483277) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483305..2483311) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2483404) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2483405..2483614) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2483405..2483614) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2483610..2483614 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2483614 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2483623..2483637 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2483635..2483646) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483646) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483661..2483667) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2483708..2484913) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2483708..2484913) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2484917..2486062) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2484917..2486062) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2486063..2487206) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2486149..2486156 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2486167..2486256 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2486167 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2486169..2486188 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2486257..2487594 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2486257..2487594 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2487192..2487211) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2487206) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2487226..2487233) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2487570 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2487689..2489377) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2487689..2489377) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2487690) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2489378..2489483) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2489460..2489468 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2489471..2489490) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2489479..2489498 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489483) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2489483 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2489484..2489573 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2489485..2490044) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2489506..2489508) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2489574..2490380 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2489574..2490380 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2490048..2490067) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2490061) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2490079..2490086) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2490330..2490376) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2490352) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2490377..2491000) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2490377..2491000) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2490381..2490723 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2490701..2490708 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490723..2490742 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2490725..2490868 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2490725 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2490840..2490844 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490860..2490879 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2490870..2491000 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2490870 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2491002..2491126 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2491002 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2491016..2491034) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2491018..2491037 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2491034) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2491045..2491053) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2491127..2491618 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2491127..2491618 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2491597 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2491656..2493395) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2491656..2493395) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2491674) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2492869..2492876 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2492890..2492908 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2492893 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2492895..2493490 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2493425..2493444) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2493433) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2493435..2494268) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2493471..2493478 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2493492..2493689 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2493492..2493511 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2493492 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2493549..2493681 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2493549..2493681 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2493690..2494292 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2493690..2494292 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2494215 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2494270..2494489) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2494278 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2494313) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2494325 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2494370..2494543 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2494485..2494503) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494497) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2494501 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2494518..2494524) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2494563..2495831) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2494563..2495831) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2494589) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2495855..2496128) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2495855..2496128) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2495876..2496019) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2495919) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2496126..2496145) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496138) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2496158..2496165) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2496173..2497891) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2496173..2497891) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2497905..2497912 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2497919..2497938) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2497927..2497946 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2497933 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2497942) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2497952..2497958) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2497975..2497982 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2497996..2498015 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2497999 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2498052..2498684 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2498052..2498684 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2498257..2498265 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2498279..2498298 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2498285 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2498711..2499355 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2498711..2499355 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2499352..2500515 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2499352..2500515 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2500506 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2500526..2501254) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2500526..2501254) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2500562) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2501244..2502062) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2501244..2502062) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2502125..2503129) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2502125..2503129) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2502142) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2503164..2503183) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2503179) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2503181..2503289) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2503289..2503308) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503289) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2503291..2503356) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2503322..2503328) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2503402) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2503405..2504481) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2503405..2504481) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2504522..2504541) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2504542) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2504544..2504644) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2504556..2504563) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2504578 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2504632..2504651) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504644) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2504665..2504671) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2504717..2505043) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2504717..2505043) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2504726) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2505067..2505522) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2505067..2505522) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2505553..2505975) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2505553..2505975) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2505996..2506014) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506009) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2506028..2506034) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2506048..2506066) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2506057) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2506077..2506085) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2506137..2507435) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2506137..2507435) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2506146) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2507460..2507479) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507461) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2507463..2507659) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2507492..2507501) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2507642..2507661) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507659) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507673..2507679) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2507685..2510543) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2507685..2510543) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2510577..2510596) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2510587) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2510612..2510616) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2510686) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2510703..2511308) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2510703..2511308) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2511324..2512133) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2511324..2512133) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2512148..2512471) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2512148..2512471) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2512472..2512610) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2512510..2512626) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2512510..2512626) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2512597..2512616) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2512610) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2512618..2512625 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512640..2512659 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512645 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2512706..2513152 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2512706..2513152 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2513153..2513881 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2513207..2514280) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2513207..2514280) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2513226) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2514302..2514321) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514306) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2514335..2514342) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2514377..2514380 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2514395..2514414 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2514400 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2514439..2514756 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2514439..2514756 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2514756 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2514809..2516509) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2514809..2516509) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2514828) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2516541..2516559) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2516548) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2516574..2516580) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2516591..2517361) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2516591..2517361) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2517362..2517450) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2517448..2517467) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2517450) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2517483..2517487) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2517507..2518148) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2517507..2518148) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2517517) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2517582) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2518174..2518193) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2518183) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2518185..2518633) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2518209..2518213) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2518292..2518298 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2518313..2518324 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2518320 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2518355..2518633 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2518355..2518633 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2518634..2518804 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2518634..2519248) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2518634..2519248) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2518782 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2519249..2519584) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2519576..2519595) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519584) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2519610..2519617) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2519611..2521767) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2519611..2521767) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2521308,2521310) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2521793..2522722) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2521793..2522722) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2522771..2523685) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2522771..2523685) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2523448..2523466) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2523456) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2523480..2523486) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2523711..2524262) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2523711..2524262) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2524125..2524144 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2524128 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2524285..2524304) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2524297) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2524320..2524323) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2524345..2524352 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2524363..2524382 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2524366..2524377) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2524370 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2524380) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524391..2524397) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2524411..2525346 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2524411..2525346 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2525322 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2525380..2526771) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2525380..2526771) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2525392) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2526772..2527212) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2526798..2526803 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2526817..2526836 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2526830 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2526868..2528166 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2526868..2528166 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2527189..2527208) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527212) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2527223..2527229) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2528153 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2528206..2529363) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2528206..2529363) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2528231) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2528479..2528484 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2528499..2528517 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2528507 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2529360..2530070) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2529360..2530070) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2530084..2530099) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530101) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2530111..2530120) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2530127..2530128 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2530140..2530245 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2530140 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2530148..2530158 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2530211..2530217 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530232..2530251 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2530247..2530360 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2530247 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2530361..2530582 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2530361..2530582 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2530565 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2530634 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2530703..2531422) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2530703..2531422) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2530717) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2531488) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2531491..2533125) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2531491..2533125) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2533157..2533176) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2533173) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2533243..2533247 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2533263..2533282 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533281 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2533327..2534589 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2533327..2534589 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2534590..2534688 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2534662..2534668 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2534684..2534702 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2534690..2534777 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2534690 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2534778..2536316 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2534778..2536316 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2536296 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2536353..2536535) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2536353..2536535) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2536372) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2536550..2536568) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2536570) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2536584..2536589) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2536603..2537271) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2536603..2537271) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2537293..2538579) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2537293..2538579) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2538591..2539094) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2538591..2539094) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2539091..2540212) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2539091..2540212) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2540220..2541185) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2540220..2541185) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2541211) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2541212..2541231) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2541246..2541253) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2541341..2541348 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2541361 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2541364..2541383 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2541401..2543719 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2541401..2543719 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2543709 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2543760..2545256) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2543760..2545256) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2543762) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2545281..2546141) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2545281..2546141) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2546217..2546236) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546226) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2546252..2546259) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2546348..2547109) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2546348..2547109) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2546377) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2547110..2547185) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2547186..2548373) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2547186..2548373) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2548442..2549449) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2548442..2549449) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2549452..2550147) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2549452..2550147) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2550144..2551313) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2550144..2551313) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2550180..2550187 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2550202..2550221 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2550220 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2551303..2552649) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2551303..2552649) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2551719..2551723 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2551738 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2551739..2551757 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2552639..2553415) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2552639..2553415) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2553416..2553508) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2553494..2553513) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2553508) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553528..2553535) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2553625..2554524) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2553625..2554524) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2554547..2554565) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554564) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2554576..2554584) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2554654..2554661 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2554677..2554696 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554683 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2554742..2555776 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2554742..2555776 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2555725..2555732 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555747..2555755 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2555764 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2555810..2557090 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2555810..2557090 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2557083..2557994 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2557083..2557994 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2557991..2558821 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2557991..2558821 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2558794..2558798 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2558814..2558833 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2558822 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2558841..2560139 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2558841..2560139 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2560120 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2560161..2560472) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2560161..2560472) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2560172) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2560496..2560515) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2560504) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2560530..2560537) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2560538 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2560589..2563003) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2560589..2563003) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2560593) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2563004..2563099) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2563113..2563327) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2563113..2563327) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2563144) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2563339..2563358) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2563360) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2563364..2563369 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2563373..2563378) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563385..2563403 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2563398..2563838 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2563398 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2563430..2563765) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2563430..2563765) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2563760..2564024) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2564009..2564028) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2564024) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2564043..2564050) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2564063..2564070 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2564084..2564103 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2564100 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2564102..2564169 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2564170..2564955 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2564170..2564955 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2564956..2565012 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2565192..2566385) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2565192..2566385) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2565212) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2566386..2566484) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2566465..2566484) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566484) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2566498..2566505) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2566522..2566525 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566540..2566559 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566544 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2566574..2567320 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2566574..2567320 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2567215 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2567314 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2567357..2569297) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2567357..2569297) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2567368) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2569287..2570048) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2569287..2570048) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2570072..2570090) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2570091) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2570150..2571154) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2570150..2571154) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2570189) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2571147..2571842) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2571147..2571842) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2571866..2571884) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2571878) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2571900..2571903) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2571939..2573249) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2571939..2573249) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2571961) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2573239..2573934) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2573239..2573934) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2573949..2574926) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2573949..2574926) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2574956..2575942) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2574956..2575942) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2575812..2575821 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2575828 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2575834..2575849 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2575936..2576814) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2575936..2576814) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2576807..2577199) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2576807..2577199) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2577200..2577444) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2577233..2577370) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2577233..2577370) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2577368 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2577439..2577458) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577444) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577472..2577479) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2577525..2577797) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2577525..2577797) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2577532) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2577837..2577848) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2577841..2577849 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2577841) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2577852 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577863..2577869) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2577863..2577881 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2577892..2577897 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2577911..2577930 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2577918 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2577959..2578927 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2577959..2578927 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2578924..2579508 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2578924..2579508 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2579472 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2579498..>2579629) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2579498..>2579629) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2579539) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2579632..2579633 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2579633..2579648) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2579639..2579658) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579648) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2579650..2579784) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2579670..2579677) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2579759..2579778) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2579784) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2579877..2581268) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2579877..2581268) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2579885) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2581269..2581403) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2581404..2583302) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2581404..2583302) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2582460..2582466 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2582481..2582492 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2582493 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2583303..2583426) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2583452..2584654) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2583452..2584654) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2583471) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2584697..2584708) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2584703) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2584705..2584821) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2584722..2584728) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2584822..2584960) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2584822..2584960) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2584920 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2584969..2584988) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2584984) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2585005..2585009) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2585081..2585088 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2585100 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2585102..2585121 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2585157..2586740 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2585157..2586740 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2586729 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2586779..2587021) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2586779..2587021) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2586793) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2587073..2587846) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2587073..2587846) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2587847..2587937) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2587913..2587922 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2587926..2587945) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2587934 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2587935..2587954 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587939) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587960..2587967) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2587997..2589001 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2587997..2589001 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2589014..2589796 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2589014..2589796 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2589018..2590566) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2589771..2590583 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2589771..2590583 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2590568 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2590610..2591086) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2590610..2591086) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2590611) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2591116..2591135) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2591129) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2591131..2591265) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2591265) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2591267..2591278) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2591293..2591299) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2591295..2591699) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2591295..2591699) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2591727..2591746) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591744) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2591746..2591832) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2591759..2591768) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2591865..2592302) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2591865..2592302) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2591877) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2592319..2592337) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592337) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2592339..2592564) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2592352..2592358) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2592394..2592413 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2592395..2592571 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2592395..2592571 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2592396 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2592565..2593002) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2592565..2593002) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2592591 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2593021..2593040) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2593042) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2593051..2593059) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2593122..2593595) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2593122..2593595) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2593131) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2593218) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2593596..2593947) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2593667..2593674 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2593687..2593706 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2593692 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2593724..2593951 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2593724..2593951 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2593948..2594511) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2593948..2594511) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2594536..2594555) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2594551) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2594605..2594853) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2594605..2594853) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2594626) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2594881..2594900) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2594914..2594921) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2594918) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2594980..2594986 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2595000..2595011 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2595012 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2595058..2596389 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2595058..2596389 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2596433..2597473 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2596433..2597473 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2597467..2597473 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2597488..2597499 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2597498 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2597527..2597685 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2597527..2597685 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2597674 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2597704..2598591) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2597704..2598591) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2597727) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2598581..2599888) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2598581..2599888) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2599894..2600646) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2599894..2600646) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2600665..2601585) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2600665..2601585) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2601621..2601632) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2601622) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2601624..2601715) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2601646..2601652) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2601700 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2601701..2601720) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2601703..2601715 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2601715) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2601717..2601798) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2601735..2601742) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2601798) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2601807..2601826) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2601840..2601847) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2601865..2602980) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2601865..2602980) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2601908) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2602977..2604437) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2602977..2604437) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2603880..2603898) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2603884) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2603913..2603919) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2604526) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2604528..2605343) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2604528..2605343) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2605378..2606202) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2605378..2606202) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2605460..2605479) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2605460) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2605495..2605498) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2605626) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2605636..2605647) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2605662..2605668) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2606190..2607932) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2606190..2607932) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2607929..2609344) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2607929..2609344) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2609345..2609457) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2609437..2609456) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2609457) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2609459..2609609) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2609472..2609475) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2609570..2609576 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2609590..2609609) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2609590..2609601 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2609598 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2609609) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2609623..2609632) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2609634..2610353 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2609634..2610353 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2609704..2610361) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2610342 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2610362..2611180) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2610362..2611180) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2611201..2611220) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611215) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2611235..2611243) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2611281..2611289 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2611302..2611321 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2611303 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2611352..2612638 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2611352..2612638 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2612635..2613585 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2612635..2613585 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2613588..2614811 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2613588..2614811 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2614735) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2614812..2615379 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2614885..2615316) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2614885..2615316) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2614911) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2615318..2616373) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2615318..2616373) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2616388..2617521) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2616388..2617521) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2617554..2617573) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2617573) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2617586..2617595) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2617659..2617668 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2617682..2617701 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2617684 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2617711..2618784 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2617711..2618784 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2618008..2618014 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2618025 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2618028..2618039 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2618773 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2618811..2618817 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2618832 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2618833..2618851 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2618864..2619331 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2618864..2619331 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2619303 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2619362..2621758) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2619362..2621758) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2619377) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2621745..2623199) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2621745..2623199) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2623196..2624227) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2623196..2624227) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2624251..2625393) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2624251..2625393) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2625390..2627273) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2625390..2627273) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2626099..2627518 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2627305..2627320) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2627318) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2627335..2627340) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2627385) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2627506..2627577) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2627506..2627577) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2627603..2627693) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2627603..2627693) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2627697..2627771) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2627697..2627771) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2627782..2627858) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2627782..2627858) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2627874..2627947) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2627874..2627947) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2627958..2628033) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2627958..2628033) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2628051..2628126) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2628051..2628126) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2628139..2628215) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2628139..2628215) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2628227..2628303) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2628227..2628303) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2628321..2628413) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2628321..2628413) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2628420..2628496) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2628420..2628496) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2628499..2628575) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2628499..2628575) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2628595..2628667) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2628595..2628667) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2628673..2628749) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2628673..2628749) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2628765..2628841) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2628765..2628841) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2628851..2628936) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2628851..2628936) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2628951..2629025) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2628951..2629025) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2629031..2629117) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2629031..2629117) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2629128..2629203) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2629128..2629203) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2629241..2629316) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2629241..2629316) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2629349..2629424) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2629349..2629424) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2629445..2629562) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2629445..2629562) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2629618..2632545) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2629618..2632545) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2632713..2634267) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2632713..2634267) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2634069,2634071) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2634268..2634559) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2634395..2634403 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2634401 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2634511 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2634532..2634551) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634559) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2634561..2635527) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2634565..2634572) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2634684..2634687 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2634699 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2634702..2634721 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2634732..2634833 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2634732..2634833 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2634832 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2634933..2635511 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2634933..2635511 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2635501 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2635553..2636074) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2635553..2636074) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2635571) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2635643) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2636092..2637621) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2636092..2637621) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2637642..2638166) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2637642..2638166) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2638210..2638225) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2638216) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2638218..2638305) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2638237..2638246) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2638290..2638308) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2638300 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2638304..2638323 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2638305) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2638323..2638328) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2638334..2638822 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2638334..2638822 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2638799 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2638828..2639406) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2638828..2639406) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2638844..2639235 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2638855) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2639440..2639459) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2639449) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2639473..2639480) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2639494..2640702) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2639494..2640702) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2639515) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2640471..2640490) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640483) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640505..2640512) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2640719..2642191) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2640719..2642191) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2642242..2642261) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642243) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642276..2642283) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2642303..2642309 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2642323..2642342 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2642338 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2642390..2642932 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2642390..2642932 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2642915 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2643009..2643016 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2643029..2643129 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2643029 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2643031..2643050 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2643130..2643675 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2643130..2643675 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2643662 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2643767..2643774 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2643788..2643807 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643795 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2643800..2643968 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2643800..2643968 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2643949 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2644041..2644709 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2644041..2644709 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2644716..2646053 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2644716..2646053 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2646039 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2646089..2646352) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2646089..2646352) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2646107) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2646392..2646411) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646394) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2646424..2646431) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2646461..2647309) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2646461..2647309) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2647354..2647373) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647364) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2647388..2647395) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2647470..2649005) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2647470..2649005) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2647479) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2648663..2648763 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2648723 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2648789 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2649006..2649173) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2649162..2649181) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649173) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2649175..2650052) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2649196..2649203) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2649415..2649424 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2649438..2649457 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2649438 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2649490..2649975 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2649490..2649975 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2649976..2650262 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2650082..2650154) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2650082..2650154) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2650097) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2650141) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2650165..2650184) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650185) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650199..2650202) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2650219 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2650262..2651092) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2650262..2651092) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2650273) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2651093..2651184) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2651185..2652351) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2651185..2652351) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2652347..2652351 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652359..2652373 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2652375..2652394) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652375 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2652394) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2652408..2652415) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2652473..2652480 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2652486 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2652491..2652510 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2652533..2653519 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2652533..2653519 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2653490 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2653560..2654834) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2653560..2654834) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2653573) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2654860..2655174) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2654860..2655174) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2655192..2656649) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2655192..2656649) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2656654..2657430) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2656654..2657430) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2657464..2657483) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2657480) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2657487..2659556) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2657487..2659556) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2659589..2659608) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2659601) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2659622..2659628) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2659694..2661682) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2659694..2661682) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2659713) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2661686..2661693 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2661703..2661721) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2661709..2661728 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2661716) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2661725 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2661735..2661742) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2661791 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2661796..2663781) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2661796..2663781) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2661801) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2663802..2663820) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2663817) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2663819..2663906) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2663834..2663841) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2663907..2665895) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2663907..2665895) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2665920..2665938) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2665935) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2665952..2665959) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2666072..2668060) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2666072..2668060) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2666091) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2668081..2668099) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2668102) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2668112..2668119) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2668162..2668171 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2668185..2668204 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2668188 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2668218..2668955 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2668218..2668955 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2668243..2668262) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2668251) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2668278..2668282) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2668956..2671776 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2668969..2669223) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2668969..2669223) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2668995) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2669224..2669480) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2669481..2669879) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2669481..2669879) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2669839..2669973) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2669839..2669973) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2669922..2669941) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669929) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2669956..2669962) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669999..2671663) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2669999..2671663) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2670015) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2670971..2670990) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2670976) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2671004..2671011) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2671688..2671706) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2671705) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2671722..2671727) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2671790..2673079) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2671790..2673079) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2671799) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2672608..2672614 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2672628..2672646 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2672634 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2672638..2673290 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2673123..2673800) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2673123..2673800) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2673133) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2673475..2674151 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2673835..2673854) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2673842..2674105) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2673842..2674105) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2673856) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2673868..2673875) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2674117..2674135) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674131) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2674151..2674156) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2674152..2674484 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2674152..2674484 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2674169..2674175 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2674190..2674207 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2674201 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2674481..2675467 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2674481..2675467 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2675442) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2675464..2675868) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2675464..2675868) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2675869..2675927) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2675928..2676299) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2675928..2676299) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2676358..2677710) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2676358..2677710) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2676369) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2676525..2676543) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676542) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2676559..2676564) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2677683) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2677686..2677697) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2677742..2677761) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677748) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2677750..2677821) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2677776..2677779) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2677822..2678994) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2677822..2678994) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2678157..2679078 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2679027..2679046) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2679040) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2679063..2679066) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2679098..2680261) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2679098..2680261) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2679113) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2680276..2680295) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2680294) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2680296..2680451) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2680310..2680317) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2680347..2680353 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2680368..2680386 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2680378 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2680379..2680437 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2680424..2680430 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2680426..2680437) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2680439 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2680444..2680455 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2680451..2680457) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2680451) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2680453..2680764) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2680491..2680727 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2680491..2680727 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2680687 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2680753 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2680805..2681197) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2680805..2681197) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2680809) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2681239..2681258) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2681246) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2681248..2681398) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2681274..2681278) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2681301..2681307 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2681314..2682298 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2681314 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2681322..2681340 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2681399..2682559) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2681399..2682559) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2682451..2682457 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2682469 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2682471..2682475 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2682560..2683060) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2682560..2683060) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2683090..2683109) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2683096..2683102 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2683111) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2683117..2683128 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2683117 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683120..2683127) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2683129..2683207 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2683208..2684029 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2683208..2684029 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2684009 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2684056) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2684058..2684318) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2684058..2684318) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2684308..2684311 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2684326..2684345 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2684338 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2684339..2684404 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2684344..2684363) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684349) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684375..2684381) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2684405..2685568 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2684405..2685568 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2685631..2685637 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2685649..2685668 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2685659 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2685694..2686980 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2685694..2686980 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2686696..2687438) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2686975..2686982 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2686996..2687015 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2686997 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2687026..2687412 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2687026..2687412 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2687394 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2687439..2688056) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2687439..2688056) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2688091..2688109) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688108) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2688110..2690198) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2688124..2688129) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2688172..2688175 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2688190..2688209 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2688201 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2688267..2689445 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2688267..2689445 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2689483..2689489 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2689501..2689520 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2689506 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2689538..2691412 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2689538..2691412 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2690178..2690197) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690198) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690211..2690220) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2691433..2691846 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2691433..2691846 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2691838 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2692049..2692606) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2692049..2692606) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2692070..2692089 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2692080 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2692090) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2692102..2692783 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2692632..2692651) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692640) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2692667..2692671) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2692784..2694385 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2692784..2694385 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2694378..2695085 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2694378..2695085 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2695070 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2695249..2695256 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2695267..2695556 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2695267 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2695271..2695290 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2695557..2696636 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2695557..2696636 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2696712..2698244 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2696712..2698244 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2698237..2699283 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2698237..2699283 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2699284..2700243 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2699284..2700243 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2700244..2700365 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2700338..2700341 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2700356..2700375 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2700367 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2700397..2701743 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2700397..2701743 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2701726 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2701779..2701994) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2701779..2701994) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2701934..2701940 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2701954..2701965 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2701958 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2702005..2702023) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2702012) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2702037..2702044 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2702039..2702044) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2702059..2702154 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2702059..2702078 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2702059 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2702117..2702121 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2702137..2702156 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2702156..2702305 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2702156 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2702225..2704630 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2702225..2704630 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2704623..2705054 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2704623..2705054 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2705054..2705395 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2705054..2705395 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2705286..2705386 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2705346 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2705388..2706869 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2705388..2706869 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2706121..2707989) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2706875..2707351 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2706875..2707351 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2707351..2707635 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2707351..2707635 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2707619..2707993 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2707619..2707993 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2707964 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2708032..2708412) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2708032..2708412) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2708034) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2708431..2709075) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2708431..2709075) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2709076..2709155) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2709156..2711465) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2709156..2711465) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2710150..2710157 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2710171..2710190 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2710186 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2711059..2712030 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2711059 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2711071..2711087 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2711480..2711647) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2711480..2711647) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2711635..2712533) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2711635..2712533) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2712534..2712647) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2712641..2712660) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712647) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712674..2712680) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2712718..2712858) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2712718..2712858) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2712747) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2712859..2712945) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2712929..2712948) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712945) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712962..2712968) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2713045..2713063) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2713055) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2713078..2713084) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2713080..2713205 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2713080..2713205 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2713233..2713662) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2713258..2713263 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2713275) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2713278..2713296 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2713280 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2713319..2713687 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2713319..2713687 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2713663..2714892) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2713663..2714892) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2713688..2715001 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2714927..2714946) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2714946) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2714959 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2714961..2714968) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2715029..2716501) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2715029..2716501) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2715039) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2716382..2716386 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2716389 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2716499 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2716517..2717068) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2716517..2717068) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2717090..2717109) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717103) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717122..2717129) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2717165..2717563) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2717165..2717563) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2717564..2717634) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2717635..2717883) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2717635..2717883) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2717906..2717925) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717917) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717941..2717944) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2717956..2718177) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2717956..2718177) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2717983) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2718171 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2718195..2718214) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718201) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2718227..2718236) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2718237..2719346) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2718237..2719346) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2718998..2719005 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719020..2719039 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2719029..2719423 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2719029 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2719394..2719413) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2719410) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2719412..2719852) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2719415..2719417 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2719425 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2719427..2719432) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2719433..2719452 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2719461..2719850 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2719461..2719850 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2719891..2720127) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2719891..2720127) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2719897) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2720147..2720166) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720161) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2720163..2720303) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2720180..2720189) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720304..2720834) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2720304..2720834) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2720854..2720873) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2720865) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2720867..2720953) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2720885..2720893) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2720948..2720967) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720955) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720981..2720990) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2721032..2721763) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2721032..2721763) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2721062) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2721778..2721797) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721789) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721812..2721819) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2721826..2722281) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2721826..2722281) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2722234..2722240 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2722255..2722273 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2722263..2724630 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2722263 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2722313..2725543) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2722313..2725543) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2725540..2730027) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2725540..2730027) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2729302..2729308 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2729323..2729341 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2729329..2730291 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2729329 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2730088..2731443) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2730088..2731443) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2730109) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2731458..2731697) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2731458..2731697) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2731767..2732060) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2731767..2732060) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2731777) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2732054 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2732061..2732139) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2732102..2732109 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2732119..2732138) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732120 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2732124..2732141 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732139) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2732153..2732160) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2732198..2732203 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2732218..2732237 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2732230..2732336 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2732230 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2732405..2732411 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2732425..2732444 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732428 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2732533..2732536 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2732545 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2732548..2732567) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2732552..2732571 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2732570) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2732581..2733849 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2732581..2733849 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2732582..2732589) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2733909..2733928 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2733914 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2733951..2735087 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2733951..2735087 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2735087 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2735136..2735144 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2735154 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2735156..2735174 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2735199..2735876 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2735199..2735876 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2735860 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2735920..2736129) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2735920..2736129) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2735932) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2736145..2743281) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2736145..2743281) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2743301..2744239) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2743301..2744239) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2744267..2745886) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2744267..2745886) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2745915..2747111) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2745915..2747111) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2746959..2746966 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2746981..2747000 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2746988 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2747137..2747922) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2747137..2747922) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2747923..2748032) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2748027..2748046) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2748032) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2748034..2748115) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2748060..2748067) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2748116..2748985) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2748116..2748985) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2748986..2749066) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2749050..2749069) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2749066) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2749083..2749090) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2749199..2749795) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2749199..2749795) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2749796..2749880) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2749831..2749838 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2749848 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2749853..2749872 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2749874..2749888) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2749880) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2749896..2749900) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2749896..2750498 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2749896..2750498 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2750484 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2750568..2751896) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2750568..2751896) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2750584) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2751950..2751969) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751953) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2751984..2751991) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2752043..2753545) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2752043..2753545) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2752058) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2753110..2753124 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2753126 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2753546..2753620) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2753568..2753575 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753586..2753605 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2753588..2753702 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2753588 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2753615..2753634) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2753625) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2753703..2754179 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2753703..2754179 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2754128 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2754210..2754866) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2754210..2754866) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2754238) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2754514..2754523 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2754537..2754556 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2754554 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2754556..2755002 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2754880) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2754882..2754893) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2754908..2754914) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2754959 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2754970..2755290) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2754970..2755290) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2754984) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2755004..2755214 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2755156..2755256 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2755216..2755325 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2755216 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2755282 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2755309..2755328) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755314) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2755327..2755878 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2755343..2755350) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2755344..2755487) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2755344..2755487) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2755511..2755530) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755532) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2755546..2755549) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2755660..2756880) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2755660..2756880) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2755688) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2756881..2757008) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2757008) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2757010..2757074) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2757010..2757028) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2757044..2757049) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2757065..2757084) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757073) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757099..2757106) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2757148..2757155 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757167..2757186 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757167 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2757212..2758210 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2757212..2758210 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2757235..2757253) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757250) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757270..2757275) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2758186 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2758249..2758389) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2758249..2758389) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2758261) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2758390..2758519) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2758500..2758519) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2758519) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2758521..2758768) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2758533..2758539) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2758576..2758583 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758597..2758616 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2758605 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2758668..2759648 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2758668..2759648 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2758769) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2758773..2758784) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2758798..2758804) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2759616 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2759721) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2759722..2760345) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2759722..2760345) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2760369..2760887) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2760369..2760887) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2760934..2760953) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2760946) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2760948..2761056) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2761043..2761060) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761054) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2761075..2761082) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2761210) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2761225..2761587) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2761225..2761587) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2761618..2761637) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761628) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2761651..2761658) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2761666..2762520) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2761666..2762520) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2762236..2762255) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762244) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2762268..2762277) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2762542..2762561) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762556) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2762576..2762579) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2762643..2763857) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2762643..2763857) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2763192..2763198 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2763213..2763231 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2763220 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2763224..2763993 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2763894..2763913) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2763899) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2763928..2763935) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2763950 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2763994..2764230) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2763994..2764230) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2763995..2764411 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2764012) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2764195..2764196) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2764200..2764204) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2764202) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2764245..2764264) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2764246) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2764278..2764285) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2764388..2764393 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2764407..2764426 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2764413 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2764493..2765560 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2764493..2765560 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2765544 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2765586..2765912) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2765586..2765912) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2765609) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2765944..2765963) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2765961) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2765976..2765983) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2765996..2766000 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2766012..2766347 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2766012..2766347 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2766013..2766032 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2766018 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2766137) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2766325 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2766389..2768362) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2766389..2768362) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2766401) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2768377..2768395) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768400) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2768407..2768415) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2768470..2769399) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2768470..2769399) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2768483) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2769396..2770454) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2769396..2770454) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2770454..2771755) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2770454..2771755) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2771640..2771649 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771664..2771683 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2771671 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2771756..2771837) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2771822..2771841) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771837) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2771839..2771955) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2771856..2771863) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2771956..2772975) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2771956..2772975) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2772783..2772788 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2772804..2772822 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2772808 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2772998..2773016) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2773005) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2773014..2773019 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2773032..2773037) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2773035..2773099 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2773035..2773053 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2773035 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2773072..2773081 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2773094..2773113 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2773101 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2773128..2773628 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2773128..2773628 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2773655..2774425) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2773655..2774425) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2773683) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2774454..2774888) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2774454..2774888) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2774912..2775187) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2774912..2775187) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2775207..2775226) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775232) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2775234..2775926) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2775240..2775247) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2775250..2775256 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2775271..2775282 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2775279 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2775302..2775934 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2775302..2775934 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2775895 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2775950..2776846) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2775950..2776846) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2775971) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2776847..2776981) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2776968..2776987) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2776981) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2777003..2777007) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2777021..2777027 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777041..2777052 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2777053 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2777081..2778061 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2777081..2778061 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2777159) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2777173..2777192) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2777209..2777212) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2778053 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2778089..2778853) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2778089..2778853) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2778105) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2778867..2778885) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778875) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2778901..2778906) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2778926..2779231) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2778926..2779231) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2778934) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2779245..2779264) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2779268) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2779278..2779286) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2779296..2780684) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2779296..2780684) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2780704..2781525) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2780704..2781525) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2781543..2782391) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2781543..2782391) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2781910..2781915 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2781931..2781949 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2781945 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2782402..2782421) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2782417) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2782429..2782776) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2782429..2782776) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2782789..2782808) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782808) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2782822..2782828) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2782873..2784213) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2782873..2784213) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2782901) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2783957) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2784270..2784276 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2784290..2784309 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2784292..2784310) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2784298 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2784299..2784387 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2784309) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2784326..2784331) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2784388..2785983 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2784388..2785983 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2786128..2787477 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2786128..2787477 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2787483..2788775 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2787483..2788775 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2788788..2790272 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2788788..2790272 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2790272..2790616 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2790272..2790616 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2790338..2790341 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2790359..2790378 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2790371 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2790591 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2790632..2791019) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2790979..2790988 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2791001..2791020 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2791004 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2791040..2791171) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2791040..2791171 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2791040..2791171 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2791040..2791171) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2791172..2791240 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2791207 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2791377..2791898) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2791377..2791898) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2791889..2794126) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2791889..2794126) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2794127..2794960) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2794127..2794960) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2794957..2795574) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2794957..2795574) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2795066) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2795571..2796563) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2795571..2796563) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2796564..2796650) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2796628..2796647) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796650) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796661..2796666) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2796792..2798042) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2796792..2798042) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2798059..2799297) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2798059..2799297) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2799520..2799657 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2799520..2799657 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2799679..2799682 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799697..2799716 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2799698 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2799739..2800605 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2799739..2800605 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2800608 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2800639..2801742) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2800639..2801742) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2800654) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2801743..2802676) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2801780..2801787 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801801..2801820 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2801811 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2801862..2801868 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2801879 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2801883..2801902 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2801924..2802652 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2801924..2802652 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2802677..2803531) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2802677..2803531) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2802864..2802883) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2802876) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2803034..2803134) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2803074) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2803545..2804447) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2803545..2804447) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2804451..2805329) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2804451..2805329) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2805387..2806655) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2805387..2806655) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2806546..2806646 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2806606 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2806726) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2806736..2807722) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2806736..2807722) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2807669 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2807672..2807676 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2807765..2807784) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807778) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807799..2807806) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2807936) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2807938..2808312) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2807938..2808312) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2808376) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2808383..2808394) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2808408..2808414) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2808415..2809533) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2808415..2809533) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2809558..2809577) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809564) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2809566..2810176) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2809591..2809597) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2809630..2809639 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2809653..2809672 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2809657 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2809670..2809685) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809674) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2809692..2809696) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2809692..2809838 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2809692..2809838 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2809838..2810113 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2809838..2810113 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2809982) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2809998..2810012) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2810021..2810025) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2810093 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2810177..2810560) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2810177..2810560) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2810561..2810670) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2810671..2810949) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2810671..2810949) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2810947..2810966) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810971) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2810981..2810988) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2811112..2811218) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2811155) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2811219..2812616) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2811219..2812616) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2812414 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2812637..2813080) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2812637..2813080) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2813070..2814290) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2813070..2814290) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2814290..2815603) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2814290..2815603) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2815621..2816406) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2815621..2816406) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2816450..2816469) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2816451) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2816483..2816490) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2816507..2816526) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2816516) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2816518..2816599) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2816542..2816546) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2816563..2816810) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2816563..2816810) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2816600..2816737) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2816600..2816737) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2816738..2816822) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2816806..2816825) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816822) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2816824..2816930) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2816841..2816844) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2816931..2817308) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2816931..2817308) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2817325..2817336) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2817331) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2817350..2817356) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2817393..2818217) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2817393..2818217) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2817401) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2817550) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2817577..2817582 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2817598..2817616 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2817600 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2818231..2818899) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2818231..2818899) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2818892..2819917) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2818892..2819917) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2819918..2820022) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2820023..2820129) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2820023..2820129) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2820092 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2820156..2820175) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2820168) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2820170..2820243) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2820191..2820198) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2820244..2820588) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2820244..2820588) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2820589..2820694) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2820695..2821015) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2820695..2821015) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2821017..2821457) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2821017..2821457) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2821457..2821693) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2821457..2821693) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2821469) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2821708) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2821713..2821724) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2821739..2821745) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2821749..2822132) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2821749..2822132) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2822159..2822178) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2822170) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2822191..2822198) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2822199..2822555) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2822199..2822555) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2822578..2822597) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2822588) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2822611..2822616) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2822666..2824450) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2822666..2824450) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2822676) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2824465..2825640) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2824465..2825640) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2825651..2828020) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2825651..2828020) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2827439..2827444 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2827459..2827477 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2827462 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2828088..2828107) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2828091) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2828099..2828365) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2828121..2828128) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2828146..2828152 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2828167..2828178 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2828189 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2828195..2828341 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2828195..2828341 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2828342..2829368 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2828366..2829274) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2828366..2829274) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2829275..2829797) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2829369..2829614 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2829369..2829614 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2829627..2829959 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2829627..2829959 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2829780..2829799) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2829797) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2829813..2829822) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2829948 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2830020..2830027 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2830041..2830060 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2830052 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2830118..2830585 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2830118..2830585 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2830582..2832207 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2830582..2832207 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2832192 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2832243..2832626) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2832243..2832626) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2832645..2833034) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2832645..2833034) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2833056..2833385) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2833056..2833385) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2833420..2833439) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2833427..2833434 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2833434) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2833449..2833468 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2833453..2833460) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2833459 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2833519..2834406 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2833519..2834406 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2834426..2834713) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2834426..2834713) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2834438) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2834738..2835565) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2834738..2835565) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2834754) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2835566..2835703) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2835688..2835707) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835703) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2835723..2835726) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835783..2836220) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2835783..2836220) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2836244..2836262) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2836250) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2836278..2836283) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2836330..2837838) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2836330..2837838) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2836351) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2837829..2838125) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2837829..2838125) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2838148..2838167) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2838164) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2838182..2838185) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2838202..2838207 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838219..2838238 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838219 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2838259..2839101 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2838259..2839101 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2838631..2838637 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2838652..2838663 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2838660 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2839128..2839135 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2839144 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2839147..2839166 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2839191..2839652 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2839191..2839652 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2839628 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2839696..2841072) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2839696..2841072) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2839704) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2841073..2841244) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2841225..2841244) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841244) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841255..2841262) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2841305..2841324) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2841315..2841334 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2841317 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2841323) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2841325..2842388) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2841339..2841346) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2841350..2842027 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2841350..2842027 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2842024..2843379 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2842024..2843379 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2842478..2843406) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2843347 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2843407..2843571) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2843407..2843571) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2843595..2843602 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843616..2843635 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2843620..2843639) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2843626..2843738 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2843626 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2843633) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2843635..2843913) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2843653..2843660) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2843739..2844614 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2843739..2844614 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2843903..2843922) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843913) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2843915..2844456) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2843936..2843943) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2844448..2844466) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2844456) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2844458..2844587) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2844479..2844486) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2844589 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2844632) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2844650..2846038) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2844650..2846038) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2846062) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2846067..2846085) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2846096..2846104) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2846105..2846290) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2846105..2846290) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2846294 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2846334..2846353) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2846343..2846349 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2846348) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2846363..2846374 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2846366 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2846369..2846372) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2846408..2847856 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2846408..2847856 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2847404..2850047) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2847825..2848922 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2847825..2848922 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2848919..2850040 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2848919..2850040 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2850048..2850683) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2850048..2850683) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2850661..2851743) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2850661..2851743) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2851740..2852465) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2851740..2852465) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2852499..2853371) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2852499..2853371) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2853390..2853409) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2853410) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2853424..2853427) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2853472..2854149) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2853472..2854149) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2853488) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2854176..2854556) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2854176..2854556) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2854579..2854598) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2854599) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2854613..2854616) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2854718..2855986) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2854718..2855986) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2854731) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2856020..2856039) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856031) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2856054..2856061) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2856157) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2856163..2856744) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2856163..2856744) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2856767..2858095) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2856767..2858095) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2858095..2859156) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2858095..2859156) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2859119..2860063) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2859119..2860063) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2860064..2860333) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2860172..2860302) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2860172..2860302) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2860310..2860329) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2860333) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2860335..2861262) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2860345..2860352) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2860395..2860402 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860417..2860436 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860421 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2860461..2861252 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2860461..2861252 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2861123 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2861233 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2861290..2862168) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2861290..2862168) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2861307) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2862192..2862210) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2862211) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2862224..2862230) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2862240..2863982) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2862240..2863982) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2863979..2864692) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2863979..2864692) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2864723..2864742) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2864741) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2864845..2865084) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2864845..2865084) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2864852) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2865080..2865098) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2865088..2865618) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2865088..2865618) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2865089) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2865113..2865119) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2865621..2865640) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865628) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2865633..2865971 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2865633..2865971 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2865655..2865662) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2865671..2865690) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865683) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2865705..2865711) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2865717..2865817 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2865777 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2865945..2866045 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2866005..2866091 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2866005 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2866092..2867249 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2866092..2867249 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2867235 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2867310..2867720 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2867310..2867720 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2867719 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2867754..2868983) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2867754..2868983) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2867771) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2868976..2869665) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2868976..2869665) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2869649..2870842) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2869649..2870842) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2870886..2870905) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870899) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870920..2870927) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2871013..2871822) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2871013..2871822) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2871030) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2871169..2871178 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2871191..2871210 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2871195 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2871838..2872848) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2871838..2872848) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2872848..2874002) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2872848..2874002) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2873935..2873954) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873952) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2873966..2873973) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2874014..2874021 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2874036..2874055 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2874045 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2874100..2875047 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2874100..2875047 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2875023 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2875067 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2875221 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2875282..2876691) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2875282..2876691) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2875297) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2876109..2876113 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876131..2876147 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2876138 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2876145..2877112 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2876793) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2876795..2876974) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2876795..2876974) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2877004..2877021) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2877015) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2877036..2877043) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2877069 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2877091..2877231) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2877091..2877231) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2877101) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2877259) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2877261..2877849) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2877264..2877275) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2877289..2877295) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2877321..2877328 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2877342 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2877344..2877363 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2877398..2877880 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2877398..2877880 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2877894..2877901 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877915..2877934 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877927 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2877980..2879833 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2877980..2879833 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2879819 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2879861..2880787) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2879861..2880787) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2879873) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2880799..2880818) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880820) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2880834..2880837) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2880856..2880875 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2880865 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2880898..2881680 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2880898..2881680 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2881652..2882344 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2881652..2882344 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2882336 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2882375..2883205) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2882375..2883205) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2882381) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2883068..2883072 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2883088..2883092 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2883097 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2883207 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2883235..2883254) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883253) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2883269..2883276) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2883361..2883367 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2883381 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2883382..2883400 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2883428..2883913 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2883428..2883913 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2883912 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2883957..2885969) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2883957..2885969) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2883965) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2885635..2885639) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2885637) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2885970..2886121) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2886098..2886116) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2886121) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2886224..2887939) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2886224..2887939) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2886231) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2887965..2889782) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2887965..2889782) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2889824..2889843) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2889833..2889840 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2889843) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2889846 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2889853..2889872 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2889856..2889863) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2889953..2892277) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2889953..2892277) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2889971) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2892297..2892304 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892319..2892338 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2892320..2892335) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2892323 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2892325) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2892370..2892389) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892379) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892405..2892411) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2892415..2892434) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892435) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892448..2892456) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2892462) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2892475..2893083) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2892475..2893083) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2893122..2893141) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893139) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2893157..2893161) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2893270..2893686) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2893270..2893686) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2893280) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2893691..2894359) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2893691..2894359) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2894411..2894430) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2894426) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2894437) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2894444..2894449) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2894479..2896587) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2894479..2896587) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2896579..2896680) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2896674..2896693) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896680) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2896709..2896716) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2896747..2899155) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2896747..2899155) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2896769) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2896835) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2899156..2899238) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2899239..2899448) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2899239..2899448) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2899472..2899491) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2899493) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2899504..2899510) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2899522..2899827) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2899522..2899827) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2899791..2899810 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2899802 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2899841..2899860) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2899867) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2899874..2899880) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2899919..2899925 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2899940..2899958 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2899948 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2899955..2901031 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2899955..2901031 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2901018 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2901068..2901703) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2901068..2901703) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2901081) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2901704..2901801) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2901781..2901800) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901801) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901814..2901820) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2901863..2903758) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2901863..2903758) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2903809..2903820) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903809) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2903835..2903841) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2903908) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2903921..2904322) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2903921..2904322) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2904319..2904678) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2904319..2904678) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2904675..2905247) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2904675..2905247) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2905285..2905304) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2905290) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2905318..2905325) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2905358..2906152) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2905358..2906152) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2906173..2906191) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906185) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906206..2906212) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2906218..2906237) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906229) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2906231..2906296) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2906251..2906258) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2906338..2906697) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2906338..2906697) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2906341) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2906681..2906689) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906691) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906704..2906709) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2906749..2906768) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906757) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2906759..2906823) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2906781..2906785) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2906823) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2906824..2906843) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2906858..2906865) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2906874..2907344) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2906874..2907344) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2907171..2907271 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2907231 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2907341 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2907389..2907408) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2907395) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2907397..2907488) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2907424..2907427) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2907489..2909828) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2907489..2909828) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2908589..2908592 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2908608..2908611 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2908617 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2909847..2910587) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2909847..2910587) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2910243..2910261) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2910255) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2910276..2910282) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2910615..2910633) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2910629) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2910717) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2910719..2910949) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2910719..2910949) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2910979..2910998) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2911000) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2911013..2911016) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2911038..2911044 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2911058..2911069 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2911059 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2911098..2911868 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2911098..2911868 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2911120..2911128 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2911139..2911157 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2911169 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2911908..2912141) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2911908..2912141) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2912232..2912239 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2912247 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2912251..2912270 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2912293..2912700 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2912293..2912700 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2912730..2913149 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2912730..2913149 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2913187..2913194 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913208..2913227 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913215 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2913241..2913567 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2913241..2913567 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2913568..2913652 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2913623..2913630 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913643..2913661 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913654 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2913692..2915392 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2913692..2915392 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2914408..2915401) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2915370 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2915432..2916112) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2915432..2916112) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2915446) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2915806..2915812 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2915827..2915845 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2915832..2918583 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2915832 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2916129..2917049) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2916129..2917049) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2917061..2917714) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2917061..2917714) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2917731..2918876) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2917731..2918876) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2918877..2918944) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2918944) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2918945..2918964) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2918975..2918979 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2918979..2918982) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2918995..2919013 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2919000 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2919095..2919099 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2919115..2919134 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2919118 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2919160..2919693 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2919160..2919693 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2919360..>2919759) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2919682 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2919759,2919766) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2919760..2919765 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2919766..2919841 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2919766..2919832) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2919837..2920526) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2919837..2920526) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2919877) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2920469..2920477 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2920491..2920510 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2920505 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2920544..2921455) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2920544..2921455) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2921475..2922128) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2921475..2922128) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2922151..2923293) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2922151..2923293) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2923337..2923356) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2923352) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2923371..2923374) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2923490..2923497 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923510..2923529 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923521 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2923557..2924114 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2923557..2924114 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2924115..2924879 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2924132..2924767) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2924132..2924767) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2924145) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2924808..2924826) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2924814) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2924842..2924848) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2924853..2924860 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924872..2924891 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2924881 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2924917..2925531 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2924917..2925531 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2925517 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2925585..2925588 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925603..2925622 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2925611 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2925663..2926361 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2925663..2926361 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2926334 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2926397..2928214) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2926397..2928214) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2926416) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2926587) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2928256..2928275) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2928260..2928279 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2928265 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2928269) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2928334..2928801 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2928334..2928801 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2928798 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2928846..2930138) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2928846..2930138) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2928856) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2930168..2931703) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2930168..2931703) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2931696..2932457) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2931696..2932457) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2932488..2933672) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2932488..2933672) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2933673..2933913) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2933913) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2933915..2933988) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2933927..2933946) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2933962..2933966) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2933989..2934996) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2933989..2934996) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2934915..2934918 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2934935..2934937 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2934937 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2935043..2936065) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2935043..2936065) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2935059) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2935087..2935088) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2936066..2936177) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2936103 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2936158..2936177) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2936177) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2936179..2936289) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2936191..2936198) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2936272..2936291) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2936287) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2936304..2936313) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2936363..2937757) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2936363..2937757) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2936377) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2937856..2937875) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2937870) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2937890..2937897) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2937897..2937904 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2937918..2937937 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2937924 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2937961..2939049 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2937961..2939049 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2939029 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2939098..2940108) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2939098..2940108) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2939105) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2940109..2940186) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2940176..2940195) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940186) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940209..2940216) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2940265..2941143) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2940265..2941143) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2940801..2940807 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940822..2940833 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940833 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2941177..2941184 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2941190..2941209) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2941195) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2941198..2941217 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941200 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2941223..2941227) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2941243..2942160 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2941243..2942160 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2942149 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2942201..2943544) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2942201..2943544) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2943613..2943848) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2943613..2943848) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2943747) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2943849..2943945) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2943946..2944980) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2943946..2944980) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2945002..2945020) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945008) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945033..2945040) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2945088..2945810) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2945088..2945810) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2945104) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2945810..2947249) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2945810..2947249) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2946797..2946800 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2946817 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2946818..2946822 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2946971 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2947125 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2947126..2947127 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2947276..2947992) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2947276..2947992) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2947896..2947903 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2947917..2947919 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2947917 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2947990 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2947993..2948059) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2948056..2948075) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2948059) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2948090..2948097) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2948167..2948769) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2948167..2948769) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2948786..2949901) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2948786..2949901) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2949905..2950642) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2949905..2950642) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2949931..2949950) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2949945) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2949962..2949969) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2950643..2951548) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2950643..2951548) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2951568..2951586) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2951579) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2951602..2951605) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2951757..2951764 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2951775..2951794 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2951782 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2951832..2952641 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2951832..2952641 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2952677..2953888 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2952677..2953888 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2953875 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2953942..2955231) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2953942..2955231) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2955311..2957374) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2955311..2957374) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2957393..2958244) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2957393..2958244) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2958248..2959504) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2958248..2959504) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2959544..2960809) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2959544..2960809) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2960841..2960860) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960863) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2960875..2960882) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2960950..2961942) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2960950..2961942) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2960984) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2962072..2962121) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2962095) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2962122..2962781) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2962122..2962781) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2962782..2962887) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2962879..2962898) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962888) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2962913..2962916) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2962940..2962947 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962962..2962981 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962962 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2962965..2963070 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2962971..2962988) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962975) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2962996..2963002) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2963071..2964762 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2963071..2964762 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2964747 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2964789..2966099) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2964789..2966099) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2964792..2965862 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2964801) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2965919..2965938 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2965919..2966177 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2965919 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2966113..2966132) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966128) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966147..2966150) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2966178..2966396 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2966178..2966396 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2966375 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2966403,2966410) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2966404..2966409 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2966441..2966444 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2966450 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2966461..2966479 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2966495..2967964 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2966495..2967964 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2967941 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2967967..2968158 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2967967..2968158 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2968137 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2968185..2968670) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2968185..2968670) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2968693..2969004) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2968693..2969004) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2969056..2969148) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2969056..2969148) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2969188..2969207) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969205) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969221..2969228) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2969279..2969962) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2969279..2969962) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2969297) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2969978..2971333) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2969978..2971333) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2971345..2971360) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2971361) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2971372..2971381) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2971635..2971642 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2971656..2971675 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2971659 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2971681..2971871 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2971872..2973293 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2971872..2973293 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2973287 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2973367..2974917 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2973367..2974917 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2974961..2974967 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2974981..2974992 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2974981 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2975025..2976587 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2975025..2976587 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2976565 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2976577..2977266 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2976577..2977266 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2976616..2976623 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976637..2976656 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976646 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2977247 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2977345) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2977348..2977683 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2977348..2977683 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2977683..2978003 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2977683..2978003 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2978004..2978194 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2978039..2978551) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2978039..2978551) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2978171 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2978587..2978598) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978593) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2978613..2978619) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2978666..2978802) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2978709) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2978803..2980146) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2978803..2980146) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2980175..2980194) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980183) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2980207..2980216) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2980208..2980213 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2980229..2980247 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980232 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2980441..2980450 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2980459 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2980464..2980483 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2980502..2981464 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2980502..2981464 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2981465..2981718 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2981745) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2981749..2981824) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2981749..2981824) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2981851..2981870) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981872) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2981886..2981889) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2981955..2981961 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2981971..2982046 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2981971 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2981976..2981995 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2982023..2982030 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982044..2982063 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982048 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2982094..2982687 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2982094..2982687 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2982676 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2982721..2983119 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2982733..2983413) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2982733..2983413) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2982757) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2983410..2985095) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2983410..2985095) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2985088..2987361) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2985088..2987361) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2987339..2988223) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2987339..2988223) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2988229..2989065) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2988229..2989065) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2989066..2990373) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2989066..2990373) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2989431..2989440 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2989453..2989472 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2989457 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2990413..2991666) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2990413..2991666) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2991667..2991761) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2991762..2993531) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2991762..2993531) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2993452..2993457 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2993473..2993491 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2993483 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2993569..2993588) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2993582) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2993601..2993608) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2993644..2994594) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2993644..2994594) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2994609..2994627) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2994622) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2994639..2994647) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2994728) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2994800..2995375) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2994800..2995375) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2994812) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2995418..2995437) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2995424..2995431 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2995434) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2995441 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2995444..2995463 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2995452..2995459) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2995492..2995812 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2995492..2995812 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2995793 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2995839) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2995839..2997431) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2995839..2997431) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2997450..2998043) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2997450..2998043) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2998085..2998104) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998098) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2998119..2998123) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2998169..2998174 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998190..2998208 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998191 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2998364..2998371 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998385..2998404 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998389 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2998426..2999403 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2998426..2999403 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2999375 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2999441..3001381) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2999441..3001381) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2999465) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3001356..3002135) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3001356..3002135) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3002136..3002217) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3002218..3003288) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3002218..3003288) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3003282..3003995) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3003282..3003995) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3004041..3004060) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004053) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3004055..3004316) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3004073..3004076) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3004076..3004083 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3004094..3004113 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3004099 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3004142..3004351 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3004142..3004351 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3004329 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3004361) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3004387..3005151) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3004387..3005151) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3004409) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3005152..3005409) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3005152..3005409) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3005433..3006383) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3005433..3006383) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3006406..3007359) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3006406..3007359) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3007361..3008248) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3007361..3008248) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3008273..3008749) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3008273..3008749) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3008769..3008788) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3008783) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3008804..3008808) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3008827..3008846) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3008840) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3008861..3008864) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3008916..3009066) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3008959) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3009067..3010017) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3009067..3010017) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3010018..3010105) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3010094..3010113) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010105) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3010107..3010198) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3010128..3010131) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3010146..3010152 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010166..3010184 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010180 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3010181..3013567 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3010223..3011644) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3010223..3011644) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3010243) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3010367) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3011271..3011275 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3011281 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3011560..3011564 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3011567 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3011645..3011842) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3011765 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3011830..3011849) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3011842) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3011861..3011868) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3012025..3013479) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3012025..3013479) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3012045) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3013480..3013604) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3013525 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3013605..3015374) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3013605..3015374) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3015375..3015449) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3015438..3015457) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3015449) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3015539..3015898) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3015539..3015898) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3015559) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3015913..3017823) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3015913..3017823) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3017825..3018550) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3017825..3018550) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3018551..3018639) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3018639..3018658) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3018639) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3018641..3018770) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3018674..3018677) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3018796..3019425) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3018796..3019425) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3018815) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3019422..3020180) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3019422..3020180) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3020177..3020914) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3020177..3020914) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3020911..3021549) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3020911..3021549) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3021407..3021507 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3021467 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3021550..3022134) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3021550..3022134) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3022131..3023414) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3022131..3023414) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3023411..3024052) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3023411..3024052) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3024045..3025220) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3024045..3025220) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3025221..3025298) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3025264..3025270 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3025282..3025301 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3025282..3025301) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025295 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3025298) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025314..3025321) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3025430..3025449 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3025437 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3025471..3026223 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3025471..3026223 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3026224..3026462 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3026245..3026256) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3026251) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3026271..3026277) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3026463..3027128 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3026463..3027128 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3027099 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3027148..3027666) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3027148..3027666) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3027182) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3027670..3028320) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3027670..3028320) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3028317..3029255) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3028317..3029255) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3029279..3030088) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3029279..3030088) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3030102..3031034) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3030102..3031034) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3031076..3031095) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031082) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3031111..3031116) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3031151..3031158 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3031170 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3031173..3031190 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3031216..3032406 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3031216..3032406 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3032204..3032210 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3032225 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3032226..3032244 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3032403..3033131 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3032403..3033131 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3033149..3033880 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3033149..3033880 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3033900..3037769) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3033900..3037769) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3034022) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3037789..3037800) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037796) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037815..3037821) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3037859..3037865 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037879..3037898 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3037884 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3037934..3038407 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3037934..3038407 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3038408..3038515 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3038448..3039665) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3038448..3039665) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3038461) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3038487..3038492 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3038507..3038518 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3038517..3038802 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3038517 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3038759 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3039681..3040427) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3039681..3040427) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3040428..3040614) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3040600..3040619) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040614) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040633..3040640) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3040748..3040755 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3040770..3040789 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3040782 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3040783..3040852 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3040853..3041362 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3040853..3041362 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3041258..3042596) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3041299) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3041383..3042594 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3041383..3042594 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3042592 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3042622..3042981) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3042622..3042981) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3042637..3043353 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3042641) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3042983..3043180) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3042983..3043180) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3043185..3044282) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3043185..3044282) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3044307..3044633) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3044307..3044633) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3044686..3044701) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3044701) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3044703..3045193) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3044713..3044722) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3044781..3044784 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3044799..3044818 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3044809 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3044851..3045081 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3044851..3045081 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3045184..3045203) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3045194) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3045219..3045223) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3045280..3045762) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3045280..3045762) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3045288 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3045303) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3045435) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3045443..3045446) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3045523..3045527) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045523) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3045543..3045546) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3045763..3045896) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3045924..3048797) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3045924..3048797) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3045941) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3048805..3050790) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3048805..3050790) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3050824..3050843) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050836) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3050838..3050923) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3050855..3050862) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3050968) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3050976..3051206) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3050976..3051206) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3051233..3051252) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3051243) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3051245..3051309) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3051266..3051273) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3051286..3051304) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3051307) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3051319..3051325) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3051375) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3051401..3051501) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3051441) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3051523..3051530 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3051544..3051563 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3051561 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3051653..3054148 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3051653..3054148 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3054163..3054167 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3054181 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3054224..3054793 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3054224..3054793 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3054824..3056158 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3054824..3056158 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3056139 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3056206..3057399) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3056206..3057399) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3056215) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3056280) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3057400..3057477) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3057403) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3057478..3057816) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3057478..3057816) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3057791..3057907) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3057791..3057907) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3057908..3057997) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3057979..3057997) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057997) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3057999..3058079) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3058011..3058016) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3058065..3058083) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3058079) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3058097..3058104) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3058216..3059658) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3058216..3059658) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3058305) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3059704..3059715) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3059715) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3059730..3059736) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3059798..3060688) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3059798..3060688) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3059815) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3060681..3061367) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3060681..3061367) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3061368..3061500) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3061490..3061509) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061500) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3061524..3061527) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3061601..3061939) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3061601..3061939) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3061602) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3061966..3061985) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3061979) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3061988..3062872) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3061988..3062872) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3061999..3062006) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3062860..3062879) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3062881) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3062894..3062901) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3064029..3064100), complement(3062999..3064027)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3062999..3064100) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3063015) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3064101..3064169) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3064170..3066695) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3064170..3066695) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3066696..3066776) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3066766..3066785) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3066776) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3066863..3067432) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3066863..3067432) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3066871) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3067399..3067405 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3067418..3067437 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3067425 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3067459..3067477) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067467) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3067469..>3067570) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3067489..3067497) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3067570..3067571 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(3067574..3068056) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3067574..3068056) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3068072..3068338) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3068072..3068338) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3068339..3068418) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3068419..3068838) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3068419..3068838) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3068877..3068895) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3068888) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3068909..3068916) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3068912..3069634) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3068912..3069634) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3069598..3069894) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3069598..3069894) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3069920..3069939) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069933) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3069950..3069957) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3069954..3071345) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3069954..3071345) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3071359..3071378) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3071374) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3071392..3071399) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3071451..3072296) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3071451..3072296) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3071462) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3071713..3071720 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3071734..3071753 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3071744..3073476 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3071744 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3072323..3072342) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072342) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072357..3072360) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3072394..3073083) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3072394..3073083) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3072408) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3073084..3073165) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3073166..3074323) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3073166..3074323) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3074324..3074451) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3074371..3074374 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3074389..3074408 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3074400..3074486 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3074400 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3074445..3074464) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074451) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3074468..3074476 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3074475..3074482) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3074488 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3074490..3074498 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3074540..3075193 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3074540..3075193 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3074896..3075488) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3075193..3076368 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3075193..3076368 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3075484..3075502) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075493) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3075516..3075522) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3076340 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3076441..3077517) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3076441..3077517) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3076457) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3076503..3076512 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3076526..3076545 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3076534..3077767 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3076534 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3077518..3077600) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3077588..3077607) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3077600) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3077619..3077625) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3077662..3078855) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3077662..3078855) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3077692) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3078884..3079642) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3078884..3079642) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3079666..3080346) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3079666..3080346) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3080375..3081841) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3080375..3081841) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3081842..3081925) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3081926..3083311) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3081926..3083311) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3083373..3084542) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3083373..3084542) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3084539..3085990) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3084539..3085990) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3086046..3086195) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3086046..3086195) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3086140..3086679) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3086140..3086679) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3086735..3086752) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3086739) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3086906..3088396) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3086906..3088396) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3086928) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3088435..3090552) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3088435..3090552) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3090576..3090884) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3090576..3090884) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3090790 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3090880..3090884 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090893..3090907 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3090894..3090912) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090900 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3090926..3090933) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3090929) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3090950..3090958 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090972..3090985 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090990 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3091068..3091988 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3091068..3091988 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3091978 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3092028..3093170) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3092028..3093170) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3092052) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3093209..3093228) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093223) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3093243..3093246) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3093299..3093303 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3093319..3093338 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3093320..3093415 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3093321 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3093416..3094294 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3093416..3094294 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3094295..3095386 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3094364..3094719) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3094628..3094846 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3094628..3094846 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3094720..3094803) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3094720..3094803) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3094804..3094995) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3094996..3097698) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3094996..3097698) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3097699..3097821) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3097720..3097726 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097741..3097759 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3097746..3100578 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3097746 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3097822..3099162) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3097822..3099162) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3099203..3099409) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3099203..3099409) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3099410..3100283) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3100277..3100296) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100283) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3100285..3100524) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3100309..3100315) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3100506..3100524) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3100524) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3100538..3100545) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3100547..3100554 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3100566..3100585 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3100580..3100710 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3100580 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3100652..3100752 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3100712 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3100716..3101312 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3100716..3101312 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3100910 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3101351..3102934) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3101351..3102934) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3101394 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3102954..3103781) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3102954..3103781) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3103782..3103846) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3103842..3103861) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103846) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3103848..3103945) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3103877..3103880) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3103946..3106186) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3103946..3106186) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3106186..3108207) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3106186..3108207) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3106949..3106958 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106971..3106986 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106982 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3108208..3108367) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3108368..3108757) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3108368..3108757) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3108758..3108892) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3108876..3108895) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108892) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3108906..3108913) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3109047..3109053 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3109064..3109156 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3109064 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3109065..3109084 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3109157..3109927 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3109157..3109927 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3109284..3109632) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3109636..3109647) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109640) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109662..3109668) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3109952 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3109960..3111105 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3109960..3111105 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3111093 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3111147..3111154 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111169..3111188 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3111179 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3111225..3112553 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3111225..3112553 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3112548 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3112609) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3112633..3112634 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3112657 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3112710..3113951) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3112710..3113951) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3112729) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3113973..3113991) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3113995) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3114004..3114011) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3114092..3114259) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3114092..3114259) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3114119) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3114274..3115416) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3114274..3115416) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3115435..3115884) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3115435..3115884) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3115578..3115584 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3115592 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3115598..3115616 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3115605..3117814 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3115899..3117080) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3115899..3117080) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3117794..3117801 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3117816 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3117817..3117836 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3117837) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3117842..3117856) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3117864..3117868) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3117864..3118844 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3117864..3118844 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3118693..3118700 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118714..3118733 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3118729 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3118846..3119727 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3118846..3119727 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3119724..3120119 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3119724..3120119 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3120135..3121616 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3120135..3121616 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3121618..3122586 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3121618..3122586 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3122598..3123515 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3122598..3123515 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3123524..3123530 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3123545..3123563 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3123547 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3123597..3124133 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3123597..3124133 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3124116 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3124161..3124271 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3124240..3124246 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124261..3124272 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124273 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3124289..3124585 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3124289..3124585 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3124586..3125238 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3124625..3125152) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3124625..3125152) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3124635) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3125172..3125191) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125185) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3125196 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3125205..3125212) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3125251) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3125252..3126019) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3125252..3126019) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3126081..3127793) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3126081..3127793) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3126692..3126701 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3126715..3126734 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3126715 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3127847..3127866) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127852) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3127872..3127879 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3127881..3127885) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3127893..3127912 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3127903 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3127951..3128859 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3127951..3128859 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3128927..3128935 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3128937..3129069 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3128937 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3128949..3128968 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3129070..3130398 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3129070..3130398 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3130389 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3130455..3131132) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3130455..3131132) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3130465) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3131192..3132334) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3131192..3132334) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3132371..3132390) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132379) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3132381..3132461) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3132404..3132412) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3132462..3133550) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3132462..3133550) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3133551..3133664) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3133606..3133615 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3133628..3133647 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3133641 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3133664) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3133668..3133682) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3133691..3133695) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3133691..3134278 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3133691..3134278 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3133779..3134258 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3133779..3134258 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3134162..3134359) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3134195 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3134205) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3134264 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3134343 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3134358..3134377) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134364) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3134386..3134393 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3134390..3134399) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3134408..3134427 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3134414 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3134452..3135069 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3134452..3135069 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3135070..3135170 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3135127 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3135196..3135205 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3135217..3135232 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3135218 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3135247..3135582 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3135247..3135582 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3135538..3135556) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135547) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3135571..3135576) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3135581 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3135587..3137164) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3135587..3137164) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3135626..3137337 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3137315..3137322 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137333..3137352 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137339 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3137378..3137854 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3137378..3137854 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3137868..3138461 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3137868..3138461 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3138458..3138994 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3138458..3138994 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3138975 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3139021..3139242) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3139021..3139242) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3139189 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3139196..3139197 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3139239..3139784) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3139239..3139784) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3139801..3139808 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139823..3139842 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139827 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3139907..3140788 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3139907..3140788 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3140873..3141589) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3140873..3141589) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3140893) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3141599..3142063) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3141599..3142063) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3142053..3143861) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3142053..3143861) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3143880..3144140) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3143880..3144140) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3144150..3144572) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3144150..3144572) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3144573..3144655) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3144647..3144666) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144655) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3144679..3144686) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3144789..3144914) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3144789..3144914) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3144832..3144963) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3144875) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3144964..3145749) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3144964..3145749) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3145750..3145865) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3145858..3145877) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145865) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3145891..3145898) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3145941..3147263) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3145941..3147263) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3145953) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3147297) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3147299..3147424) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3147299..3147317) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3147333..3147338) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3147404..3147423) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3147424) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3147458..3148222) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3147458..3148222) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3148241) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3148275..3148988) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3148275..3148988) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3148292) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3148978..3149724) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3148978..3149724) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3149756..3149775) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149768) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3149792..3149795) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3149958..3150101) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3149958..3150101) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3149979) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3150102..3150187) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3150177..3150188) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3150187) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3150189..3150419) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3150226..3150230 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150246..3150265 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150255 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3150305..3151915 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3150305..3151915 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3150407..3150425) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150419) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3150421..3150595) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3150439..3150446) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3150582..3150601) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150595) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3150615..3150623) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3151902..3154670 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3151902..3154670 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3154719) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3154796..3155653) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3154796..3155653) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3155659..3156435) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3155659..3156435) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3156461..3156480) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156483) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3156485..3156557) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3156495..3156502) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3156559..3156658) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3156602) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3156659..3157000) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3156659..3157000) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3157022..3157041) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157041) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157055..3157062) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3157077..3157460) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3157077..3157460) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3157482..3157501) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3157489..3157508 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3157493 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3157502) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3157516..3157523) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3157583..3157602 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3157586 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3157635) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3157635..3158045 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3157635..3158045 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3158046..3158129 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3158087 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3158185..3158493) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3158185..3158493) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3158186) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3158837..3159673 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3158837..3159673 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3159053..3159060 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3159075..3159094 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3159078 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3159672 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3159720..3160112) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3159720..3160112) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3159726) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3160185..3160610) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3160185..3160610) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3160671..3160690) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160687) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3160689..3160773) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3160705..3160712) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3160752 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3160755..3160774 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3160765..3160784) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3160773) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3160775..3161859) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3160798..3160803) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3160802..3161866 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3160802..3161866 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3161867..3162751 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3161889..3162698) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3161889..3162698) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3161904) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3162732..3163544) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3162732..3163544) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3163545..3163624) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3163575..3163582 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3163596..3163615 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3163605 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3163618..3163636) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3163624) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3163650..3163657) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3163707..3164708) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3163707..3164708) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3163713) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3164763..3164782) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3164787) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3164789..3164873) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3164874..3165155) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3164874..3165155) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3165170..3165280) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3165170..3165280) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3165311..3165329) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165333) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3165345..3165350) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3165426..3165432 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3165446..3165465 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3165462 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3165505..3165918 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3165505..3165918 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3165940..3167130 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3165940..3167130 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3167221..3168627) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3167221..3168627) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3167518) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3168660..3168679) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168678) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3168694..3168697) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3168733..3170205) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3168733..3170205) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3170386..3171744) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3170386..3171744) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3170400) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3171744..3172313) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3171744..3172313) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3172332..3172343) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172350) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3172357..3172363) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3172420..3172587) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3172420..3172587) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3172497..3172961) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3172497..3172961) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3172991..3173010) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172996) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3173024..3173031) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3173162..3173165 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3173180..3173199 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3173184 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3173243..3174457 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3173243..3174457 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3174073..3174091) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174074) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3174105..3174112) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3174323..3174329 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3174343..3174362 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3174345 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3174469..3174819 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3174469..3174819 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3174812 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3174871..3174879 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3174893..3174901 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3174900 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3174942..3174951 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3174964..3174979 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3174968 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3175000..3175581 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3175000..3175581 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3175098..3175117) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175108) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3175131..3175139) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3175562 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3175622..3176044) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3175622..3176044) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3175641) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3176079..3176094) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176098) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176107..3176116) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3176155..3177006) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3176155..3177006) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3176164) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3176406) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3176643..3176645 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3176662..3176681 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3176663..3177009 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3176663 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3177001..3177004 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3177011..3177146 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3177011 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3177040) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3177046..3177055) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3177147..3177638 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3177147..3177638 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3177376..3177381 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3177397..3177415 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3177408 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3177499..3178407) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3177635..3178153 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3177635..3178153 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3177958 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3178156 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3178312..3178443 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3178312..3178443 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3178440..3178874) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3178440..3178874) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3178452) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3178923..3178942) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178930) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3178932..3179229) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3178957..3178964) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3179003..3179007 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3179024..3179043 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3179036..3179116 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3179037 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3179117..3180565 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3179117..3180565 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3179229) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3179230..3179248) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3179231..3179574) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3179264..3179270) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3179552..3179570) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3179574) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3179586..3179591) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3180554 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3180586..3181359) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3180586..3181359) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3180608) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3181434..3181437 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181453..3181472 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181457 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3181504..3181887 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3181504..3181887 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3181874 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3181922..3182563) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3181922..3182563) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3181972) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3182631..3183032) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3182631..3183032) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3183081..3183100) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183091) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3183093..3183166) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3183115..3183120) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3183167..3184876) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3183167..3184876) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3184873..3185247) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3184873..3185247) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3185244..3185561) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3185244..3185561) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3185562..3185646) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3185646) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3185648..3185661) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3185648..3185741) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3185742..3185906) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3185742..3185906) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3185829..3185847) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3185841) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3185859..3185867) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3185907..3186078) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3186079..3186261) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3186079..3186261) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3186262..3186408) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3186396..3186415) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3186408) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3186410..3186524) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3186430..3186437) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3186511,3186513) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3186538 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3186541..3186545 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3186558..3186746) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3186558..3186746) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3186569) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3186736 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3186772..3186790) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3186783) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3186804..3186810) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3186819..3187319) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3186819..3187319) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3187355..3187374) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3187362) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3187388..3187394) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3187454..3188587) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3187454..3188587) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3187472) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3188614..3188633) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3188621) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3188684..3188702) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3188700) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3188716..3188723) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3188779..3189804) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3188779..3189804) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3188792) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3189820..3190608) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3189820..3190608) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3190634..3190653) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190640) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3190642..3190853) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3190667..3190674) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3190854..3191015) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3190854..3191015) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3191028..3191046) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3191048) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3191060..3191066) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3191109..3191783) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3191109..3191783) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3191124) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3191836..3191976) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3191836..3191976) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3192107..3192790) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3192107..3192790) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3193167..3193171 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3193176..3194207) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3193176..3194207) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3193186..3193205 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3193192) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3193204 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3194235..3194253) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194248) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3194250..3194367) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3194269..3194274) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3194309..3194314 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3194326..3196986 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3194326 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3194330..3194348 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3194403..3195713) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3194403..3195713) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3194412) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3195737..3195756) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195744) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3195747..3196487) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3195747..3196487) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3195770..3195779) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3196118) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3196120..3196128) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3196142..3196150) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3196242..3196257) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196250) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196270..3196279) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3196488..3196615) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3196616..3196846) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3196616..3196846) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3196847..3197109) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3196982..3197001 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3196988 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3197016..3197489 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3197016..3197489 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3197093..3197112) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3197109) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3197111..3197494) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3197127..3197130) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3197523..3197921) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3197523..3197921) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3197539) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3197913..3197931) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197922) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197945..3197951) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3197945..3199366) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3197945..3199366) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3199392..3200255) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3199392..3200255) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3200256..3200331) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3200332..3201840) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3200332..3201840) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3201857..3202402) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3201857..3202402) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3202399..3202911) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3202399..3202911) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3202912..3203073) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3203074..3203286) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3203074..3203286) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3203332..3204066) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3203332..3204066) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3203880..3203980 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3203940 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3204074..3204457) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3204074..3204457) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3204146..3204164) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3204148) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3204458..3204728) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3204690..3204699 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3204699 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3204704..3204723) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3204713..3204732 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3204728) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3204730..3204851) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3204736..3204743) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3204880..3205509) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3204880..3205509) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3204896) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3205553..3205572) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3205576) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3205587..3205594) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3205644..3206891) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3205644..3206891) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3205667) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3206933..3206952) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3206950) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3206952..3207036) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3206967..3206972) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3207081) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3207098..3207640) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3207098..3207640) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3207653..3208102) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3207653..3208102) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3208103..3208202) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3208194..3208213) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3208202) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3208227..3208234) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3208259..3208711) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3208259..3208711) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3208728..3208747) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3208746) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3208762..3208765) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3208787..3209344) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3208787..3209344) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3209371..3209389) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3209384) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3209405..3209410) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3209423..3210463) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3209423..3210463) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3209428) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3210464..3210528) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3210518..3210537) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3210528) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3210530..3210619) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3210553..3210557) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3210620..3211063) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3210620..3211063) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3211130..3211804) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3211130..3211804) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3211566..3211584) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3211573) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3211599..3211605) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3211836..3211853) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3211837) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3211869..3211874) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3211910 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3211914..3211933 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3211945..3212307 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3211945..3212307 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3212320) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3212324..3212611) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3212324..3212611) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3212612..3212670) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3212668..3212687) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3212671..3213537) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3212671..3213537) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3212684) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3212700..3212709) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3213539..3214609) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3213539..3214609) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3213542) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3214610 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3214637..3214656) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3214661) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3214663..3214774) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3214670..3214676) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3214706..3214725 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3214720 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3214735..3215121 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3214735..3215121 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3214756..3214774) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3214774) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3214788..3214795) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3215189..3215197 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3215208..3215226 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3215209 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3215243..3215797 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3215243..3215797 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3215727..3215731 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3215732 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3215776 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3215831..3216790) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3215831..3216790) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3215853) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3216828..3216846) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216842) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3216861..3216867) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3216872..3218620) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3216872..3218620) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3217346..3217364) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217354) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3217379..3217385) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3218621..3218711) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3218695..3218714) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218711) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3218728..3218735) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3218854) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3218859..3219446) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3218859..3219446) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3219535..3219735) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3219535..3219735) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3219548) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3219736..3219813) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3219809..3219828) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219813) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3219842..3219849) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3219854..3221137) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3219854..3221137) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3221138..3221440) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3221168..3221329) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3221168..3221329) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3221420..3221439) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221440) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3221455..3221459) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3221544..3222509) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3221544..3222509) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3221550) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3222126..3222135 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222148..3222167 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222156 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3222540..3223829) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3222540..3223829) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3223830..3224189) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3224208..3224846) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3224208..3224846) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3224234) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3224847..3224965) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3224966..3225823) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3224966..3225823) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3225824..3225950) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3225932..3225951) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3225950) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3225965..3225972) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3226004..3226378) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3226004..3226378) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3226418..3226436) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3226432) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3226434..3227073) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3226435..3226438 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3226447..3226455) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3226454..3226473 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226467 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3226481..3226486 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226502..3226521 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226512 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3226544..3227065 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3226544..3227065 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3227008..3227011 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3227026..3227045 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3227040 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3227063..3227082) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3227073) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3227084 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3227097..3227104) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3227147..3228754) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3227147..3228754) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3227160) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3228755..3228942) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3228930..3228949) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3228942) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3228964..3228971) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3228996..3229517) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3228996..3229517) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3229052) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3229518..3229620) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3229601..3229620) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229620) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3229622..3229699) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3229636..3229639) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3229700..3230839) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3229700..3230839) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3230836..3232953) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3230836..3232953) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3232954..3233012) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3233013..3233032) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233026) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233046..3233053) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3233052..3233058 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3233072..3233083 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3233077 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3233108..3234304 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3233108..3234304 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3233300..3234178) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3234168..3234186) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234179) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234202..3234207) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3234317..3235279 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3234317..3235279 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3235293..3235299 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235314..3235332 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235314 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3235360..3235632 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3235360..3235632 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3235366) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3235622 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3235667..3236073 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3235674..3236198) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3235674..3236198) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3235696) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3236208..3237935) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3236208..3237935) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3237969..3237988) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237983) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3238002..3238008) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3238024..3239526) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3238024..3239526) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3239550..3239568) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239568) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3239583..3239589) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3239613..3239985) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3239656) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3240012..3240683) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3240012..3240683) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3240030) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3240680..3241234) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3240680..3241234) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3241260..3242723) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3241260..3242723) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3242713..3246399) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3242713..3246399) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3246430..3246449) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3246454) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3246456..3246585) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3246595..3247071) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3246595..3247071) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3246630) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3247094..3247113) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3247106) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3247128..3247131) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3247178 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3247181..3247200 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3247215..3247934 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3247215..3247934 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3247918 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3247966..3248682) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3247966..3248682) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3247968) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3248038) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3248708..3248727) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3248720) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3248781..3249968) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3248781..3249968) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3249998..3250017) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3250016) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3250104..3251774) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3250104..3251774) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3250106) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3251771..3252199) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3251771..3252199) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3252267..3252281 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3252267..3252286) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3252274 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3252283) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3252303..3252306) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3252338..3252357) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3252350) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3252379,3252386) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3252380..3252385 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3252386..3254864 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3252387..3253763) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3252387..3253763) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3253802..3255157) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3253802..3255157) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3255193..3255212) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3255211) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3255225..3255234) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3255337..3255356 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3255338 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3255383) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3255387..3256532 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3255387..3256532 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3256391..3256395 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3256412..3256431 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3256419 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3256502) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3256516..3256635 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3256516..3256635 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3256620 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3256665..3256733 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3256734..3257207 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3256734..3257207 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3257196 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3257239..3258111) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3257239..3258111) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3257250) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3257316) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3258172..3259002) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3258172..3259002) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3259003..3259098) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3259086..3259105) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259097) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3259118..3259125) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3259143..3259148 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3259164..3259182 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3259166 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3259204..3261279 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3259204..3261279 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3261332) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3261456..3261571) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3261499) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3261572..3262090) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3261572..3262090) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3262104..3262763) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3262104..3262763) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3262786..3262789 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3262799..3262818) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3262804..3262823 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3262807 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3262817) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3262819..3263102) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3262833..3262840) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3262872..3263060 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3262872..3263060 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3263049 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3263103..3263522) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3263103..3263522) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3263572..3263591) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3263583) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3263606..3263613) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3263642..3265558) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3263642..3265558) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3264836..3264854) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3264841) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3264871..3264875) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3265589) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3265612..3265833) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3265612..3265833) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3265865..3266086) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3265865..3266086) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3266118..3266380) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3266129 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3266161) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3266168..3266323) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3266168..3266323) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3266330..3266333 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3266342..3266355 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3266349 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3266357..3266376) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266380) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266390..3266396) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266403..3267803) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3266403..3267803) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3267803..3268273) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3267803..3268273) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3268229) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3268385..3268885) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3268385..3268885) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3268388) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3268921..3270222) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3268921..3270222) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3270246..3270265) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270260) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3270262..3270383) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3270281..3270283) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3270384..3270608) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3270384..3270608) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3270609..3270693) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3270682..3270701) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270692) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3270716..3270719) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3270759..3270765 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3270780..3270791 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3270781 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3270823..3271599 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3270823..3271599 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3271585 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3271687..3271694 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3271709..3271728 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3271713..3275939 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3271713 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3271743..3272633) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3271743..3272633) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3272633..3272733) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3272673) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3272801..3273646) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3272801..3273646) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3272964) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3273695..3274594) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3273695..3274594) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3274637..3274656) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274640) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3274670..3274677) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3274741) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3274741..3275712) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3274741..3275712) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3275747..3275766) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275772) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3275782..3275786) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3275860..3275871) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275863) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3275885..3275891) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3275934..3275953 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3275941 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3275982..3276746 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3275982..3276746 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3276733 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3276753,3276760) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3276754..3276759 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3276760..3276812 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3276762..3278000) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3276762..3278000) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3278042..3278061) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278054) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278073..3278080) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3278210..3279622) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3278210..3279622) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3278217) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3279622..3281322) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3279622..3281322) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3280291..3280307) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3280303) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3281396..3282943) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3281396..3282943) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3281403) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3282987) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3282989..3283169) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3282990..3283008) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3283170..3284444) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3283170..3284444) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3284445..3284527) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3284527) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3284540..3284558) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3284620) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3284621..3285085) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3284621..3285085) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3285086..3285196) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3285178..3285197) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3285196) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3285212..3285219) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3285407) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3285409..3285864) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3285409..3285864) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3285499..3285518 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3285507 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3285857..3286708) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3285857..3286708) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3286722..3287669) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3286722..3287669) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3287669..3288409) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3287669..3288409) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3288427..3288432 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3288433 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3288434..3289453) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3288434..3289453) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3288447..3288465 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3289317..3289326 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3289339..3289354 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3289350 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3289456..3290178) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3289456..3290178) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3290171..3291292) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3290171..3291292) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3291292..3292161) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3291292..3292161) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3292162..3293331) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3292162..3293331) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3293352..3294776) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3293352..3294776) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3294781..3295551) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3294781..3295551) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3295586..3295605) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3295600) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3295619..3295628) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3295719..3295724 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3295740..3295758 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3295742..3295870 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3295742 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3295871..3296416 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3295871..3296416 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3296402 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3296460..3296831) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3296460..3296831) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3296478) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3296893..3298215) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3296893..3298215) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3298235..3298552) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3298235..3298552) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3298581..3298600) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298592) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3298614..3298620) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3298655..3298662 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3298678..3298697 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3298681 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3298720..3300090 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3298720..3300090 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3300115..3300792) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3300115..3300792) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3300129) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3300619..3300638) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300635) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3300654..3300659) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3300806..3301612) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3300806..3301612) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3301105..3301123) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3301119) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3301138..3301144) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3301641..3301660) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3301647) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3301676..3301683) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3301702..3302235) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3301702..3302235) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3302283..3302918) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3302283..3302918) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3302911..3303249) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3302911..3303249) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3303271..3303290) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303282) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3303305..3303312) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3303333..3303336 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303351..3303370 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303351 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3303393..3304208 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3303393..3304208 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3304187 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3304263) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3304298..3304546) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3304298..3304546) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3304318) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3304564) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3304566..3304639) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3304574..3304580) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3304640..3306079) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3304640..3306079) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3306076..3307461) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3306076..3307461) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3307480..3307489) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3307494) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3307496..3307560) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3307539..3307556) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307560) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307572..3307579) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3307602..3307621) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307620) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307635..3307642) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3307701..3307704 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3307711 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3307719..3307738 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3307763..3308533 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3307763..3308533 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3308534..3309601 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3308572..3309402) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3308572..3309402) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3308573) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3309428..3309447) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3309434) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3309442..3309744) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3309442..3309744) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3309462..3309469) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3309745..3309883) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3309868..3309887) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3309883) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3310198..3310206 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3310217..3310235 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3310218 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3310274..3312694 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3310274..3312694 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3310432 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3310441..3310460 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3312682 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3312732..3313733) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3312732..3313733) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3313734..3313895) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3313907..3314656) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3313907..3314656) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3313940) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3314674..3314693) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314691) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314708..3314711) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3314762..3315943) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3314762..3315943) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3314776) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3315944..3316075) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3316069..3316084) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3316075) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3316096..3316105) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3316310..3316317 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3316328..3316438 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3316328..3316347 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3316328 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3316439..3316702 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3316439..3316702 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3316592 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3316708 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3316745..3317119) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3316745..3317119) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3316756) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3317121..3317735) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3317121..3317735) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3317749..3319698) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3317749..3319698) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3318962..3318981 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3318968 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3319392..3319492 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3319452 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3319562 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3319726..3320691) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3319726..3320691) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3320692..3320760) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3320747..3320766) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3320760) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3320762..3320947) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3320779..3320783) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3320878..3320883 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3320899..3320917 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320904 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3320938..3320957) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3320947) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3320949..3321058) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3320972..3320976) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3321014 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3321043..3321062) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3321058) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321078..3321082) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3321136..3321154) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3321141..3321147 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3321153) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3321162..3321180 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3321165 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321170..3321175) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3321207..3321452 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3321207..3321452 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3321434 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3321523..3323064) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3321523..3323064) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3321552) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3323068..3324240) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3323068..3324240) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3324258..3324276) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3324280) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3324291..3324297) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3324321..3324704) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3324321..3324704) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3324722..3325393) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3324722..3325393) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3325415..3325434) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325424) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3325450..3325453) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3325534..3325537 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325552..3325571 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3325561..3325748 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3325561 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3325749..3325907 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3325749..3325907 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3325908..3326292 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3326273..3326278 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326294..3326312 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3326294 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3326350..3326658 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3326350..3326658 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3326436) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3326440..3326540) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3326480) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3326655..3328196 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3326655..3328196 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3328187 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3328227..3328829) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3328227..3328829) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3328241) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3328830..3329111) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3329112..3330362) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3329112..3330362) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3329208) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3330381..3331538) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3330381..3331538) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3330454..3330473) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3330481) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3331535..3332980) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3331535..3332980) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3333014..3333033) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333024) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3333047..3333054) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3333137..3333805) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3333137..3333805) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3333146) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3333802..3334620) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3333802..3334620) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3334628..3335533) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3334628..3335533) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3335268..3335287) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3335279) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3335574..3335593) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3335584..3335591 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3335595) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3335603 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3335605..3335624 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3335609..3335616) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3335639..3336025 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3335639..3336025 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3336007..3336684 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3336007..3336684 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3336656 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3336728..3336735 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3336746 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3336749..3336768 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3336788..3337987 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3336788..3337987 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3338021..3338218 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3338021..3338218 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3338197 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3338253..3339443) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3338253..3339443) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3338268) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3338352) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3339467..3339486) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3339483) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3339503..3339510 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3339519 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3339524..3339543 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3339564..3339944 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3339564..3339944 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3339842 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3339913 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3339982..3340659) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3339982..3340659) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3339989) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3340668..3340687) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340693) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3340699..3340705) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3340736..3342070) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3340736..3342070) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3342118..3342136) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3342141) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3342235..3342242 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3342247 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3342256..3342274 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3342298..3344235 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3342298..3344235 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3343442..3343461) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343443) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343475..3343483) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3344225 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3344338..3344345 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344360..3344379 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344379 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3344591..3344598 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344611..3344630 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344611 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3344663..3346042 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3344663..3346042 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3345751..3346954) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3346096..3346938 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3346096..3346938 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3346989..3347849) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3346989..3347849) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3346999) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3347833 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3347871..3347889) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3347889) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3347904..3347910) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3347959..3348672) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3347959..3348672) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3348074..3348075 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3348095..3348112 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3348097 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3348700..3348711) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348701) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348726..3348732) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3348747..3348753 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3348768..3348787 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3348778 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3348823..3349338 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3348823..3349338 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3349339..3349545 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3349339..3349545 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3349505 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3349587..3350828 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3349587..3350828 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3350919..3350927 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3350938..3350956 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3350949 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3350984..3352351 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3350984..3352351 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3352328 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3352381..3353013) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3352381..3353013) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3352399) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3353049..3353064) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353057) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3353077..3353085) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3353155..3354090) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3353155..3354090) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3353167) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3353834..3353843 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3353857..3353876 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3353861 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3354091..3354178) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3354161..3354180) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354178) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3354196..3354200) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3354223..3354235) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354223) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3354250..3354256) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3354253..3354387) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3354253..3354387) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3354334..3354341 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3354355..3354374 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3354364 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3354367..3354471 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3354466..3354475 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3354473 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3354487..3354502 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354509) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3354511..3354525) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3354537..3354686 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3354537..3354686 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3354704..3356215 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3354704..3356215 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3356212..3357399 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3356212..3357399 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3357416..3357652 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3357416..3357652 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3357652..3358830 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3357652..3358830 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3358831..3358920 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3358921..3359679 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3358921..3359679 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3359647 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3359681..3360908) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3359727..3359734 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3359748..3359767 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3359761 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3359820..3360911 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3359820..3360911 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3360813 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3360901 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3360945..3362273) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3360945..3362273) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3360953) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3362270..3362602) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3362270..3362602) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3362621..3363979) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3362621..3363979) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3363995..3364303) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3363995..3364303) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3364348..3364367) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364364) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364381..3364387) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3364432) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3364432..3366357) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3364432..3366357) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3365095..3365104 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3365118..3365137 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3365126 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3366430..3366447) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3366454) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3366462..3366469) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3366520..3366678) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3366520..3366678) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3366547) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3366707..3367297) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3366707..3367297) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3367325..3367343) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367336) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367357..3367363) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3367366..3367372 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3367388..3367406 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3367391 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3367426..3369069 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3367426..3369069 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3367563..3369112) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3369064 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3369114..3369205) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3369116..3369122 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3369130 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3369137..3369156 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3369157) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3369174..3370376 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3369174..3370376 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3369207..3370372) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3369250) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3370373..3371149) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3370373..3371149) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3371146..3372033) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3371146..3372033) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3372040..3372228) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3372040..3372228) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3372225..3372431) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3372225..3372431) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3372428..3372748) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3372428..3372748) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3372561..3372570 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3372583..3372602 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3372585 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3372741..3373277) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3372741..3373277) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3373305) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3373306..3373321) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3373333..3373342) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3373408..3373415 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3373429..3373448 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3373438 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3373489..3374862 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3373489..3374862 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3373769..3374311) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3374299..3374318) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374311) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3374333..3374340) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3374697 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3374877..3375707) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3374877..3375707) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3374883) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3375726..3375744) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375741) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3375759..3375765) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3375785) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3375787..3375806) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3375793..3377520) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3375793..3377520) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3375892) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3377517..3379220) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3377517..3379220) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3379220..3380236) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3379220..3380236) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3380110..3380128) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380119) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380144..3380149) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380220..3381626) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3380220..3381626) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3381627..3381835) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3381818..3381837) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381835) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3381837..3381945) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3381851..3381856) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3381942..3381961) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3381957) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3381975..3381982) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3382103..3382110 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3382120 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3382125..3382143 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3382182..3383534 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3382182..3383534 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3383133..3385615) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3383519 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3383610..3383629 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3383616 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3383656..3385344 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3383656..3385344 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3385342..3385351 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3385363..3385378 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3385367 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3385402..3385602 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3385402..3385602 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3385603..3386547 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3385616..3386455) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3385616..3386455) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3386481..3386499) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3386499) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3386512..3386519) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3386514 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3386562..3387659) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3386562..3387659) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3386563) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3387692..3387711) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387709) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3387711..3387779) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3387724..3387731) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3387780..3388673) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3387780..3388673) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3388700..3388719) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388719) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3388733..3388740) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3388747..3388752 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388768..3388786 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3388777 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3388794..3388800 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388815..3388833 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3388821 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3388857..3390314 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3388857..3390314 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3389740..3389758) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3389755) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3389773..3389778) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3390295 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3390339 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3390356..3391192) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3390356..3391192) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3390374) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3391269..3391371) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3391269..3391371) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3391295) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3391397..3391416) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391408) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3391410..3392151) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3391430..3391436) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3391488..3391495 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3391508..3391526 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3391517 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3391527..3391612 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3391588..3391595 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3391609..3391628 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3391614 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3391760..3392302 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3391760..3392302 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3392127..3392146) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392151) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3392160..3392169) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3392292 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3392337..3392659 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3392377..3393396) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3392377..3393396) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3392395) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3393422..3393441) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393436) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393456..3393459) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3393511..3394017) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3393511..3394017) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3394023..3394042) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394045) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3394047..3394050 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3394056..3394062) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3394065..3394084 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3394068 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3394147..3395022 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3394147..3395022 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3394397..3394485) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3394419) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3394445..3394545) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3394485) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3395100..3395573 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3395100..3395573 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3395591..3396811 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3395591..3396811 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3396798..3397454 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3396798..3397454 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3397452..3397457 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3397471..3397490 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3397474 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3397504..3398736 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3397504..3398736 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3397521) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3398721 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3398782..3398791 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3398804..3398819 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3398806..3399028 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3398806 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3398985 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3399039..3399045 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3399058..3399158 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3399058 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3399060..3399078 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3399137..3399144 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3399158..3399176 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3399160..3399257 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3399160 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3399258..3399521 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3399258..3399521 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3399285..3399288 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3399303..3399322 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3399315 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3399469 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3399513 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3399588..3399597 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3399603 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3399609..3399624 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3399650..3400138 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3399650..3400138 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3400143..3400150 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400164..3400183 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400174 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3400204..3400310 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3400204..3400310 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3400305 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3400393..3401526 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3400393..3401526 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3400666..3400909) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3400904..3400923) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400913) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400938..3400945) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3401532..3401539 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3401554..3401573 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3401560 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3401595..3401701 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3401595..3401701 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3401648 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3401702..3401778 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3401779..3402915 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3401779..3402915 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3402902 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3402968..3403741) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3402968..3403741) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3402978) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3403758..3404408) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3403758..3404408) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3404405..3405121) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3404405..3405121) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3405145..3406563) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3405145..3406563) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3405731..3405749) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3405750) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3405765..3405770) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3406564..3406648) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3406632..3406650) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3406648) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3406666..3406671) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3406717..3407565) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3406717..3407565) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3406727) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3407566..3407751) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3407740..3407759) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3407751) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3407753..3408478) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3407775..3407779) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3407913..3407920 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3407933..3407952 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3407942 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3407952..3408054 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3407952..3408054 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3408055..3408158 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3408130..3408136 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3408150..3408161 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3408160 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3408181..3409374 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3408181..3409374 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3408465..3408483) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3408481) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3408496..3408503) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3409150 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3409370 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3409416..3409844) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3409416..3409844) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3409845..3410087) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3409845..3410087) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3410088..3410151) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3410140..3410155) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410151) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3410167..3410176) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3410184 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3410232..3410522) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3410232..3410522) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3410238) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3410547..3410566) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410564) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3410572..3412632) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3410572..3412632) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3410580..3410587) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3412661..3412679) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3412665) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3412694..3412700) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3412725..3412730 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3412744 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3412746..3412764 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3412758..3412832 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3412833..3414113 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3412833..3414113 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3414114..3414253 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3414210 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3414271..3414999) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3414271..3414999) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3414288) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3415030..3415049) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415041) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3415063..3415070) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3415187..3415294) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3415230) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3415295..3416128) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3415295..3416128) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3416159..3416178) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3416178) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3416192..3416199) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3416224..3416904) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3416224..3416904) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3416951..3416970) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3416960) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3416984..3416991) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3417052..3417055 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3417070..3417089 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3417070 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3417111..3418397 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3417111..3418397 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3417842..3417860) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3417850) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3417874..3417881) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3418368 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3418416..3419855) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3418416..3419855) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3418439) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3419879..3419898) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3419896) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3419937..3421085) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3419937..3421085) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3421112..3421128) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421128) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3421130..3421214) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3421143..3421148) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3421215..3421403) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3421215..3421403) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3421434..3421565) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3421434..3421565) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3421577..3422038) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3421577..3422038) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3422054..3422350) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3422054..3422350) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3422378..3422866) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3422378..3422866) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3422884..3423336) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3422884..3423336) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3423337..3423405) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3423406..3423735) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3423406..3423735) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3423736..3423857) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3423858..3424274) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3423858..3424274) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3424325..3424693) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3424325..3424693) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3424687..3425157) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3424687..3425157) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3425158..3425482) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3425483..3425911) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3425483..3425911) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3425973..3432977) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3425973..3432977) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3432984..3432998 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3432998 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3433008..3433027) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433023) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3433042..3433049) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3433139..3434074) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3433139..3434074) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3433360) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3434075..3434195) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3434226..3434672) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3434226..3434672) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3434240) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3434709..3434728) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434716) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434742..3434749) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434775..3436184) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3434775..3436184) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3436207..3438036) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3436207..3438036) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3438028..3438128) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3438068) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3438070..3438262) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3438243..3438262) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3438262) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3438264..3438397) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3438275..3438282) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3438419..3438727) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3438419..3438727) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3438442) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3438773..3439216) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3438773..3439216) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3439213..3440922) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3439213..3440922) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3440084..3440103) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3440092) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3440942..3441211) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3440942..3441211) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3441223..3441588) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3441223..3441588) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3441589..3441654) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3441641..3441660) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441654) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3441675..3441678) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3441895..3443304) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3441895..3443304) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3441918) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3443305..3443414) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3443438..3443602) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3443438..3443602) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3443487..3443505) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3443502) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3443516..3443524) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3443794..3443813) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3443810) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3443826..3443833) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3443842..3443849 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3443864..3443883 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3443867 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3443921..3444367 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3443921..3444367 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3444372 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3444480..3446006 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3444480..3446006 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3446003..3447661 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3446003..3447661 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3447674..3448939 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3447674..3448939 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3448932..3449891 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3448932..3449891 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3449892..3449966 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3449967..3451394 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3449967..3451394 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3451390 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3451438..3452739) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3451438..3452739) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3451455) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3452769..3453950) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3452769..3453950) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3453951..3454030) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3454031..3454702) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3454031..3454702) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3454651..3454654 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3454669 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3454670..3454689 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3454730..3454749) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454745) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454763..3454770) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3454808..3455749) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3454808..3455749) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3455794..3455813) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455800) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3455802..3455882) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3455829..3455832) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3455883..3456710) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3455883..3456710) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3456682) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3456735..3456753) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456748) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456767..3456773) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3456783..3457895) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3456783..3457895) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3457965..3459302) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3457965..3459302) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3459299..3460441) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3459299..3460441) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3460458..3461207) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3460458..3461207) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3461220..3461894) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3461220..3461894) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3461917..3462711) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3461917..3462711) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3462283..3462292 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3462304 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3462305..3462320 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3462736..3463233) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3462736..3463233) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3463247..3464572) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3463247..3464572) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3464649..3464668) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464653) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3464682..3464689) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3464758..3464985) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3464758..3464985) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3464972..3465958) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3464972..3465958) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3464976) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3465109..3465118 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3465132..3465151 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3465142..3465775 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3465142 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3466013..3466032) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3466024) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3466047..3466054) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3466113..3466925) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3466113..3466925) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3466955..3466974) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3466965..3467522) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3466965..3467522) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3466978) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3466989..3466996) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3467503..3467937) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3467503..3467937) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3467962..3467971 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3467981 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3467984..3468003 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467997) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3467998..3468409) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3468003..3468017) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3468026..3468030) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3468026..3468391 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3468026..3468391 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3468405 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3468409..3468413) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468409) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3468411..3468497) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3468490..3468509) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468497) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3468523..3468530) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3468570..3468576 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3468590..3468601 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3468597 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3468639..3468992 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3468639..3468992 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3468987 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3469036..3469434) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3469036..3469434) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3469044) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3469449..3469468) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469465) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3469483..3469486) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3469522..3469529 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3469538..3469556) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3469544..3469563 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3469553 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3469553) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3469572..3469577) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3469612..3470577 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3469612..3470577 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3470005 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3470012..3470030 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3470484 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3470555 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3470600..3471396 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3470618..3470965) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3470618..3470965) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3470631) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3470979..3472847) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3470979..3472847) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3472822..3473595) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3472822..3473595) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3473739..3474716) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3473739..3474716) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3474713..3475402) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3474713..3475402) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3475429..3475448) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3475447) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3475463..3475469) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3475510..3476382) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3475510..3476382) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3475514) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3476403..3477239) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3476403..3477239) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3477240..3477324) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3477325..3478194) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3477325..3478194) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3478214..3479248) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3478214..3479248) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3479271..3480587) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3479271..3480587) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3480602..3481495) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3480602..3481495) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3481512..3483425) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3481512..3483425) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3483458..3484435) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3483458..3484435) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3484459..3485274) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3484459..3485274) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3485275..3485348) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3485349..3486812) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3485349..3486812) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3486813..3487017) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3486816..3486823 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3486839..3486858 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3486846 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3486853..3487159 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3486999..3487018) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487017) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3487019..3487171) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3487033..3487040) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3487119..3487126 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3487141..3487160 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3487161 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3487172..3487191) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3487188) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3487207..3487214) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3487228..3487983 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3487228..3487983 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3487962..3487968 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487983..3488002 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487997 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3488037..3488969 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3488037..3488969 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3488971 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3489048..3489055 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3489069..3489088 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3489075..3489230 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3489075 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3489231..3489881 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3489231..3489881 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3489885..3490193 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3489885..3490193 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3490195 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3490337..3490343 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3490359..3490377 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3490369 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3490431..3491816 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3490431..3491816 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3491802 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3491847..3492397 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3491858..3493738) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3491858..3493738) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3491864) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3493739..3493836) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3493827..3493846) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3493836) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3493861..3493868) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3493906..3494157) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3493906..3494157) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3493924) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3494179..3494198) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3494188) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3494221..3494227 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3494241..3494259 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3494242 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3494274..3495095 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3494274..3495095 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3495079 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3495124..3496266) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3495124..3496266) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3495134) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3496267..3496366) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3496354..3496373) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3496365) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3496387..3496394) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3496409..3497746 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3496409..3497746 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3497151..3497751) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3497785..3498264) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3497785..3498264) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3497796) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3498344..3499336) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3498344..3499336) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3498368) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3499326 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3499359..3499378) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499377) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3499393..3499400) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3499399..3499406 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3499420..3499844 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3499420 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3499421..3499440 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3499426..3499838 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3499426..3499838 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3499446) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3499456..3499470) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3499478..3499482) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3499810 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3499845..3500579 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3499845..3500579 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3500579..3500848 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3500579..3500848 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3500852..3501334 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3500852..3501334 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3501355..3503598 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3501355..3503598 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3503595..3504794 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3503595..3504794 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3504550..3504568) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3504572) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3504583..3504589) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3504785 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3504858) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3504858..3506090) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3504858..3506090) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3506122..3506141) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506134) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3506155..3506160) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3506191..3506616) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3506191..3506616) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3506644..3506663) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506658) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3506676..3506682) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3506808..3506815 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3506825 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3506830..3506849 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3506873..3507328 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3506873..3507328 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3507266 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3507329..3507942 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3507358..3508566) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3507358..3508566) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3507385) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3508567..3508673) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3508674..3509687) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3508674..3509687) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3509688..3509761) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3509746..3509765) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3509761) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3509778..3509785) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3509781..3510356) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3509781..3510356) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3509805) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3510385..3510404) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3510399) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3510419..3510426) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3510427..3510433 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3510448..3510466 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3510455 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3510487..3511557 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3510487..3511557 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3511555 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3511614..3512045) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3511614..3512045) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3512075..3512082 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3512096..3512115 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3512105..3512271 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3512105 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3512157..3512176) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3512177) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3512191..3512198) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3512272..3512676 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3512272..3512676 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3512293..3513345) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3512646..3513338 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3512646..3513338 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3513378..3514409) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3513378..3514409) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3513390) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3514376..3514379 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3514392 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3514396..3514415 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3514446..3514464) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514464) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3514479..3514485) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3514502..3515650) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3514502..3515650) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3515689..3515708) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515700) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515719..3515726) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3515772..3515779 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3515793..3515812 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3515800 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3515846..3516577 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3515846..3516577 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3516570..3518111 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3516570..3518111 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3518140..3519486 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3518140..3519486 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3518939..3518943 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3518959..3518978 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3518968 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3519509..3520915 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3519509..3520915 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3520904 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3521012..3521031 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3521014..3521305 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3521014 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3521278..3521285 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3521300..3521319 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3521307 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3521329..3521336 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3521351..3521370 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3521354) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3521357..3521371) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3521366 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3521379..3521383) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3521379..3521942 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3521379..3521942 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3521956..3523485 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3521956..3523485 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3523312) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3523478 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3523511..3523594) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3523554) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3523595..3525034) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3523595..3525034) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3525048..3525278) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3525048..3525278) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3525279..3525490) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3525487..3525506) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3525492) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3525521..3525528) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3525554..3525561 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3525572..3525591 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3525587 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3525622..3526332 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3525622..3526332 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3526360..3526518 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3526360..3526518 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3526595 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3526649..3527371) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3526649..3527371) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3526661) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3527272..3527275 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3527291..3527295 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3527306 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3527392..3528021) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3527392..3528021) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3528022..3528170) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3528171..3528929) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3528171..3528929) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3528619..3528638) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3528635) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3528651..3528658) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3528910..3529869) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3528910..3529869) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3529858 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3529905..3529908 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3529913 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3529927..3530076) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3529927..3530076) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3529934) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3529985..3530002 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3529990 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3530071 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3530097..3530116) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3530118) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3530131..3530138) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3530411..3530418 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3530433..3530452 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3530437 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3530548..3532473 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3530548..3532473 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3532474..3533838 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3532686..3533006) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3533007..3534767) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3533007..3534767) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3533050) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3533835..3533836 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3533840 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3534767..3535165) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3534767..3535165) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3535158..3536603) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3535158..3536603) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3535853..3535860 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3535872..3535891 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3535882..3536931 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3535882 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3536604..3536864) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3536865..3537344) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3536865..3537344) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3537345..3537424) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3537425..3537595) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3537425..3537595) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3537636..3537655) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3537652) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3537669..3537674) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3537718..3537725 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3537738..3537757 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3537755 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3537780..3538193 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3537780..3538193 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3538173 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3538227..3539453) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3538227..3539453) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3538242) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3539476..3539494) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3539481) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3539506..3539514) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3539516..3539686) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3539516..3539686) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3539705..3539723) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3539723) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3539737..3539743) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3539791..3540039) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3539791..3540039) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3540055..3541218) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3540055..3541218) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3540089..3540107) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3540097) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3540119..3540127) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3541229..3541966) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3541229..3541966) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3542008..3542026) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3542014) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3542040..3542048) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3542108..3542578) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3542108..3542578) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3542121) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3542579..3542649) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3542610..3542616 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3542630..3542649 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3542631..3542650) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3542631 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3542649) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3542651..3542926) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3542665..3542672) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3542689..3543786 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3542689..3543786 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3542917..3542935) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3542926) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3542950..3542955) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3543510..3543518 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3543530..3543548 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3543543 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3543787..3543903 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3543787..3543903 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3543892 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3544140..3545030) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3544140..3545030) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3544146) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3544208) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3545104..3546507) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3545104..3546507) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3546508..3546729) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3546730..3547935) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3546730..3547935) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3547992..3548010) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3547995) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3548105..3548110 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3548125..3548144 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3548140 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3548176..3549561 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3548176..3549561 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3549543..3549731) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3549543..3549731) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3549848..3549976) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3549848..3549976) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3549900 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3549996..3551198) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3549996..3551198) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3550020) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3551230..3551241) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3551230) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3551256..3551262) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3551280..3552074) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3551280..3552074) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3552096..3552938) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3552096..3552938) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3552925..3554292) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3552925..3554292) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3553519,3553521) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3554282..3556117) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3554282..3556117) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3556125..3556832) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3556125..3556832) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3556833..3556929) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3556917..3556936) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556929) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3556931..3557123) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3556952..3556955) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3557123) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3557133..3557152) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3557215) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3557216..3557288) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3557216..3557288) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3557324..3557400) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3557324..3557400) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3557401..3557481) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3557482..3557553) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3557482..3557553) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3557563..3557638) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3557563..3557638) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3557610..3557626 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3557623 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3557639..3557735) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3557719..3557738) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557735) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3557752..3557759) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3557769..3557870) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3557809) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3557863..3559155) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3557863..3559155) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3557874) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3559195..3559214) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559215) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3559229..3559236) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3559361..3559780) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3559361..3559780) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3559778..3559789) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559789) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3559804..3559810) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3559901..3561265) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3559901..3561265) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3559921) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3559965) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3561296..3561315) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3561310) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3561330..3561332) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3561377..3561383 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3561398..3561416 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3561400 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3561435..3561635 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3561435..3561635 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3561605 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3561650..3561971 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3561683..3561886) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3561683..3561886) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3561887..3562187) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3561952..3561955 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3561970..3561989 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3561973 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3562007..3562147 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3562007..3562147 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3562148..3562219 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3562195) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3562198..3562212) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3562220..3562224) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3562220..3563428 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3562220..3563428 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3563409 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3563533..3565590 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3563533..3565590 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3565455 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3565627..3566076) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3565627..3566076) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3565641) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3566073..3568052) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3566073..3568052) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3566554..3566573) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3566557) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3566970..3566977 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3566991..3567009 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3566995..3567661 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3566995 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3568089..3569018) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3568089..3569018) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3569019..3569155) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3569137..3569156) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569155) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569171..3569176) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3569245..3569394) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3569245..3569394) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3569271) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3569433..3569452) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3569450) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3569466..3569472) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3569473..3569482 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3569495..3569514 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3569501 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3569513) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3569515..3570028) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3569517..3569531) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3569540..3569544) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3569540..3570022 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3569540..3570022 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3570009 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3570052..3570429) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3570052..3570429) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3570054..3570583 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3570073) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3570484..3570503) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570496) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3570517..3570524) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3570565..3570569 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3570583..3570602 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3570585 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3570610..3570624) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570613) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3570634..3571563 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3570634..3571563 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3571549 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3571592) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3571596..3572042) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3571596..3572042) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3572043..3572373) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3572232..3572349) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3572232..3572349) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3572364..3572383) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3572372) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3572397..3572404) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3572410..3572416 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3572429 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3572431..3572449 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3572445..3572451 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3572466..3572477 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3572473 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3572475..3573782 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3572475..3573782 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3573583) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3573771 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3573826..3574065) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3573826..3574065) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3573847) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3573851..3573951) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3573891) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3574055..3574219) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3574055..3574219) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3574231..3574416) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3574231..3574416) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3574497 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3574689..3574835) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3574689..3574835) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3574817..3574966) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3574817..3574966) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3575282..3575298) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3575299) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3575318..3575325 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3575340..3575543 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3575340..3575359 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3575340 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3575361..3575375) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3575365) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3575544..3575981 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3575544..3575981 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3575982..3576058 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3576015 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3576095..3576850 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3576095..3576850 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3576690..3579279) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3576840..3577550 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3576840..3577550 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3577049 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3577547..3578302 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3577547..3578302 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3578299..3578954 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3578299..3578954 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3578955..3579269 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3579226 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3579270 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3579324) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3579329..3580117) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3579329..3580117) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3580141..3580159) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580160) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3580175..3580180) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3580185..3580574) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3580185..3580574) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3580643..3580646 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3580661..3580680 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3580674 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3580720..3581559 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3580720..3581559 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3581536 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3581592..3582806) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3581592..3582806) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3581610) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3582807..3582910) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3582903..3582922) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3582911..3582918 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3582913) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3582932..3582951 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3582936..3582943) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3582944 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3582993..3583871 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3582993..3583871 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3583885..3584328 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3583885..3584328 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3584411..3584890 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3584411..3584890 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3584880 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3585065..3585727) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3585065..3585727) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3585874..3586326) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3585874..3586326) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3586350..3586357 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3586372..3586391 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3586374 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3586376..3586445 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3586379..3586398) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586381) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3586411..3586418) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3586446..3586892 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3586446..3586892 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3586889..3587494 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3586889..3587494 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3587589..3588110) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3587589..3588110) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3588111..3588938) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3588159..3588166 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3588180 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3588181..3588200 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3588246..3588520 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3588246 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3588249..3588254 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3588267..3588286 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3588521..3588877 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3588521..3588877 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3588878..3589036 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3588920..3588939) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3588938) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3588954..3588961) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3589037..3589603 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3589037..3589603 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3590110..3591486) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3590110..3591486) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3591520..3591582) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3591520..3591582) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3591603..3591622) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3591622) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3591635..3591642) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3591770..3591776 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3591792..3591811 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3591798 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3591835..3592074 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3591835..3592074 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3592083 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3592167..3592174 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3592190..3592209 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3592206 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3592225..3592641 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3592225..3592641 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3592638..3593555 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3592638..3593555 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3593582..3593601 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3593592 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3593596..3593615) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3593602) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3593627..3595696 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3593627..3595696 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3593629..3593636) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3595660 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3595693..3596592) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3595693..3596592) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3595736) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3596621..3596640) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3596637) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3596639..3597870) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3596655..3596662) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3596733..3596740 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3596754..3596773 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3596760 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3596818..3598173 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3596818..3598173 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3597856..3597875) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3597880) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3597889..3597898) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3598207..3598761) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3598207..3598761) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3598779..3599159) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3598779..3599159) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3599215..3600150) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3599215..3600150) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3600140..3600149 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3600163..3600182 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3600170 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3600194..3600213) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3600208) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3600209..3600967) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3600209..3600967) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3600226..3600233) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3600500..3601003 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3600962 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3601032..3601271) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3601032..3601271) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3601038) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3601106) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3601315..3601833) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3601315..3601833) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3601874..3602161) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3601874..3602161) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3602162..3602228) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3602227..3602246) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3602228) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3602260..3602265) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3602272..3603372) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3602272..3603372) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3603420..3603439) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3603435) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3603454..3603461) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3603499..3605502) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3603499..3605502) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3605553..3605759) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3605553..3605759) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3605721..3605740) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3605746) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3605755..3605761) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3605785..3605804) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3605796) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3605821..3605825) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3605853..3606869) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3605853..3606869) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3606902..3606920) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606914) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3606936..3606941) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3607045) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3607229..3607234 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3607247..3607328 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3607247 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3607250..3607268 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3607329..3607946 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3607329..3607946 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3607917..3607925 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3607936 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3607939..3607957 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3607958 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3607985..3608833) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3607985..3608833) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3608005) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3608826..3609587) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3608826..3609587) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3609621..3609640) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3609639) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3609731) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3609734..3609742) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3609756..3609764) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3609768..3609776 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3609784 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3609788..3609806 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3609835..3610275 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3609835..3610275 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3610224 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3610326..3611177) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3610326..3611177) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3610345) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3611178..3611298) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3611299..3612018) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3611299..3612018) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3612032..3613918) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3612032..3613918) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3613939..3615318) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3613939..3615318) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3615319..3615449) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3615441..3615460) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615449) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3615476..3615480) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3615504..3615523) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3615514) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3615537..3615544) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3615604..3615610 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3615615..3617900 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3615615 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3615625..3615644 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3615629..3616255) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3615629..3616255) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3615646) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3616252..3617037) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3616252..3617037) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3617082..3617101) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3617094) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3617096..3617181) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3617113..3617119) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3617182..3617532) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3617182..3617532) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3617533..3617683) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3617684..3617818) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3617684..3617818) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3617842..3617942 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3617854..3617873) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3617864) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3617866..3617934) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3617889..3617896) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3617902..>3618035 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3617902 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3617920..3617939) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3617934) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3617955..3617959) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3618036..3618183 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3618059..3618332) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3618185..3618444 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgcgtc tgattagagc tcatttcata 570001 aattcttgtt ttttgcagca cacctgtcga ctcaagaagc aggttatcca gcaggtcagt 570061 aattaagttt ccgtggttat acacccacga cccgttccac ggattgcccc ctgcatcaac 570121 aggaagggaa ctttgcgctc caataatata atgatgagga ttagcatgtt taaccgcttc 570181 atcaagtggc gcttgatctg taccttgact gccgacacct tcaccgcctg attcatctaa 570241 taaagcattg attgtgtttt gaaccagttc aacgtgggca atctcctcta aaaaaatgcc 570301 gcgaagcaga tcgcggtact gtttctgctt tcctctgaaa ttagagcttt ggaaaaaaac 570361 tgcatcattg tacgcatttc tccgtaatga ccgcctaata tctcctgcag gaccttagca 570421 gctgccgggt ctggcttgtc cggtttaatg atattaatca gttcctcttt gtagtaatac 570481 ataacacgcc tcatttcttc ttaagagatt ttcttatatt atttgtaaga tgagataaaa 570541 tatatacatg ataagcatgg gaaggcgtga aagaagaaaa taaaaaaata caggaaaagt 570601 gttgaccaaa taaaacaggc atggtatatt attaaacgtc gctgatgaac agcgtgaaac 570661 aaaacagaaa aacaaaaaag ttttcctaag gtgtttacaa gattttaaaa atgtgtataa 570721 taagaaaagt cgaattgaaa aagattcgaa aaaacattaa aaaacttctt gacttcaaca 570781 tcaaatgata gtatgatagt taagtcgctc aataagcgcc cgtagctcaa ttggatagag 570841 cgtttgacta cggatcaaaa ggttaggggt tcgactcctc tcgggcgcgc catataagat 570901 accacgcggg tgtagtttag tggtaaaacc tcagccttcc aagctgatgt cgtgagttcg 570961 attctcatca cccgctccat tattgaatga tctttgaaaa ctaaacaaga caaaacgtac 571021 ctgttaattc agtttttgaa aatcgcacag cgatgtgcgt agtcagtcaa actagggcct 571081 gcacgatgca ggtcacacag gtgtcaccgc gggatgcggt ggacttaacc tgtgatccat 571141 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 571201 gtcgagcgaa cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 571261 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 571321 tgtttgaacc gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc 571381 cgcggcgcat tagctagttg gtgaggtaat ggctcaccaa ggcaacgatg cgtagccgac 571441 ctgagagggt gatcggccac actgggactg agacacggcc cagactccta cgggaggcag 571501 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 571561 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 571621 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 571681 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 571741 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tgggaaactt 571801 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 571861 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 571921 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 571981 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 572041 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 572101 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 572161 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 572221 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 572281 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 572341 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 572401 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 572461 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 572521 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 572581 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 572641 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 572701 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 572761 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 572821 aattagtaat acaagatatc acatagtgat tctttttaac ggttaagtta gaaagggcgc 572881 acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg atatgcttcg 572941 gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca ccactcgtaa 573001 tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg ggaactgaaa 573061 catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa 573121 cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc tgtacggagt 573181 tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag gtaacagccc 573241 tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac acgtgaaatt 573301 ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga ccgatagtga 573361 accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa 573421 accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct tttgtagaat 573481 gaaccggcga gttacgatcc cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag 573541 cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca 573601 tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca cgttgaaaag 573661 tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat agctggttct 573721 ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga gcactgattg 573781 gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca atgacttatc 573841 cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag cccagaccgc 573901 cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct tagacaacca 573961 ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac tggtcgagtg 574021 actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg 574081 aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac tggtggagcg 574141 cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc ctccaccgaa 574201 tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc taagccgagg 574261 ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc tcaccatttg 574321 agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg cgtccaagca 574381 gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat ggcgagcgaa 574441 atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg aggtgagagg 574501 tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg atcgagagaa 574561 ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta 574621 gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag caaaaacaca 574681 ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt gctggaaggt 574741 taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt 574801 aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa 574861 ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag tacctgtgaa 574921 gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc agcctgatat 574981 tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga gcgccagctt 575041 cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc cgccgccctt 575101 atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg 575161 taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag agtgtaaagg 575221 cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc gggcttagtg 575281 atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc ccggggataa 575341 caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc gatgtcggct 575401 catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca ttaaagcggt 575461 acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg 575521 aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc gctggtgtac 575581 cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa gtgctgaaag 575641 catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga agtaagatcc 575701 ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat ggagctgaca 575761 gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct gttatctagt 575821 tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca cccgttccca 575881 taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga 575941 gagtaggacg ccgccaagca ttacttttat catcgcgggg tggagcagtt cggtagctcg 576001 tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc cccgcaacca aatatatggt 576061 taaataagga gtgccctaag ggtgcaacca aaataatcct atacaaatat ggtccggtag 576121 ttcagttggt tagaatgcct gcctgtcacg caggaggtcg cgggttcgag tcccgtccgg 576181 accgccatta atgtaaacga aacgatcatg ttttcgtttt ttttgtgttt tcttttactg 576241 tatcttctgc ttggtgtcat agccaagctt tctttatatc gggaacatct tggatattcc 576301 agcaaaattc gataaactag gaagagcaca aataggcata agcagggttg aaaggaggtt 576361 ttggttcatg gatgaatttg atttgataca tagcattact ccgcggacca ttcaccattc 576421 ttccgttgat gtaggaatag gtgatgatgc agcgctctac actgcgaaac acggcgttca 576481 ggaaattgtt tgtgttgata ctatggtaga agacgtgcac ttcaaattac actattcctc 576541 acctgaagat atcgggtaca aggcgttagc cgttaatata agtgatattg ccgcgatggg 576601 aggcattcct aagttttatc tggtatcact tgcggtacct tcaaaatgga ctgaatctga 576661 aatcaaggcg atgtatgaag gaatgaatga actggcgaaa ctatatcata tggatctgat 576721 tggcggcgat acagtttcta ccgctgacaa attagtcgtt acagtcactg taatcggtga 576781 aattgaaaag ggacaggcct gtttgcgcag cttggcaaaa ccgaatgata ttgtgtttgt 576841 aaccggtgaa atcggttctt ctgcagcagg gctttcttta ttgctggaag agactaatcc 576901 tcaaaactca tctgtggaaa cggattactt tatccacagg cataaacggc ctgagccaag 576961 agtaagcgtc ggcagattat gctcgatttt taaacgggca gctttaaatg atgttagtga 577021 cggattggct agtgaactga acgagattgc agaagccagc tgtgtttcaa ttgaaattgt 577081 tgaaagcatg cttccaattc attctgattt gcctaagctt catcctaact ggaaagaatg 577141 ggctttgttt ggcggtgagg attttgagct gacagggacg gtttcaaatg aggagtggga 577201 agtgttgaag caggagtgcg cagcgcttca tcttcccatt acaaagattg gctatgtcag 577261 ggaaaaaaca aaatctaaag tgatcctaaa aacagatcaa acatcaatga tcttagagaa 577321 aaagggatat aatcatttta aataagacgg gtgactcgtg tgaagcaatt aaaatggaga 577381 actgtaaatc cagaagaaac aaaagcaatt gccaagctga cggcagcgtt tgctaaaccg 577441 ggagacgtcc tgacattaga gggcgattta ggtgcaggaa aaacgacttt tacgaaaggt 577501 tttgcagaag ggctgggaat tacacgtatt gtaaacagtc cgacttttac aattataaaa 577561 gaatataacg atggcgtact tcctctttat cacatggatg tgtatagaat ggaagatgaa 577621 agtgaagatt tgggacttga tgaatatttt cacggacaag gtgtctgtct cgttgaatgg 577681 gctcatttaa ttgaagaaca gctgccacag gagcgactgc aaattgtcat caaaagagct 577741 ggtgatgatg agcgggaaat tacctttact gctgtcggga atcggtatga aatgctttgt 577801 gaggagttaa gtagacatga caatattagc aattgataca tcaaattata cattgggcat 577861 tgcgctgctt cgagaagaca ctgttatagc agaatacatt acatatttga aaaagaacca 577921 ctctgtaaga gcgatgcctg ctgttcattc attgctgaat gattgtgata tggcaccgca 577981 ggacctttct aaaattgtcg ttgcaaaagg ccctggttca tacacaggag taagaatagg 578041 tgtgacgttg gccaaaacac ttgcctggtc tttagacatt ccaataagtg ctgtatcaag 578101 tcttgagacg cttgcggcaa atggccggca ttttgacggt ctgatcagcc caatctttga 578161 tgctagacgg ggacaggtgt acacaggtct gtatcaatat aaaaatgggc ttttagagca 578221 agttgttcca gatcaaaatg tgatgctggc agattggctg gagatgctaa aagaaaagga 578281 ccgccctgtt ttgtttttag gccatgatac ttctcttcac aagcagatga tcgaggatgt 578341 gcttggaaca aaaggattca ttggaactgc cgcccagcat aacccgcgcc cttcagaatt 578401 ggcttttctc gggaaggaaa aggaagcagc tgatgttcat gggcttgtcc cggattactt 578461 gcggctggca gaagctgaag cgaaatggat tgaaagtcaa aagtagggtg ataggatgaa 578521 aacaaaagca gcggtcagaa atatgcggct tgaagatata gatcacgtat acgaaatcga 578581 agcatcctcc tttacgtctc cttggacgaa ggattcgttt tatcatgagc tgctggaaaa 578641 tccgtatgct cattatctcg tgattgaaaa ggacggccat cttgctgggt attgcgggat 578701 ttggattgtg atggacgatg cccagattac aaatatagcg ataaaaccag agtatcgcgg 578761 ccagtcttta ggagaaacgc tttttcgctc agctgttgaa ctgtgcaaag aaaaagacgc 578821 aaggcggctt tcgcttgaag tgagggtttc gaatcatcct gctcaaggct tatataagaa 578881 attcgggatg cagcccggcg gaataagaaa gaactattat actgataacg gggaagatgc 578941 gttaattatg tgggtgacga taaatgagtg agcaaaaaga catgtacgta ttaggaattg 579001 aaacaagctg tgatgagact gctgcagcta ttgtgaaaaa cgggaaagag atcatttcaa 579061 acgtagtagc ctctcaaatt gaaagccata agcgcttcgg aggcgttgtt ccggaaattg 579121 cttcaagaca tcatgttgaa caaatcactt tggttataga agaggcgttt cgcaaagctg 579181 gcatgacgta tagtgatatt gatgcgattg cagtaacaga aggtccggga ctggtgggag 579241 cgcttcttat cggagtgaat gccgctaaag cattgagctt tgcatataac attccgttag 579301 taggcgttca tcatatagcc ggtcatatat acgcgaaccg tcttgtagaa gacatcgtgt 579361 tcccggcact ggcattggtc gtttcaggag gccatacaga actggtttat atgaaggaac 579421 atggatcatt tgaagtcatt ggggaaaccc ttgatgatgc ggcaggagaa gcctacgaca 579481 aagtggcgcg gacgatggga ttgccatatc cgggtggacc gcaaattgac aagctagctg 579541 aaaaagggaa tgacaatatt ccgcttcctc gcgcatggct tgaagaaggc tcttacaact 579601 tcagctttag cggattgaag tctgcggtga tcaatacgct tcataatgca tcccaaaaag 579661 ggcaagagat tgctccggaa gatttgtctg ccagtttcca aaatagtgtg atcgatgtct 579721 tggtaaccaa aacggcgcgc gcggcaaagg aatatgatgt caaacaggtc cttttagccg 579781 gaggagtagc tgcaaacaga ggcctcagag ctgcattaga aaaggaattt gcccagcatg 579841 aagggattac gcttgtcatt cctccattag ctttatgcac ggataatgct gcgatgattg 579901 ctgctgctgg tacaattgct tttgaaaaag gaattcgcgg tgcatatgat atgaatggcc 579961 agcccggcct tgaattgact tcttatcaaa gtctcacgag ataatagcgt gagacttttt 580021 atctgtttgt tattaacaga caattcacaa tttatccaca tatctgtgag taattataga 580081 gatattgatg gataaagggc tgaggtcact gttaataaag tggataaatt cagaatattt 580141 tgtggatagt gtgtataaag cgcttacttt gtttatttat taggggatgt tctgtggata 580201 aaaagcacct ctaaaaagag gtgcttgact tttttaatct tcttctgtgg atagttcttc 580261 ccattcggac aaaagagatt ccagctcctg attaagcttc tcattgtctg catggatagc 580321 ttgtactttt tcatgatcct gatagacttc agggtcacat agcaattcat cattgcggct 580381 gatgttctcc tcaatggttt gaacggtggt ttcaatttct tcaatccgac ggagtcgttg 580441 gcgctctttc tttttccatt ctttttcttc ctcgtaggaa cgtttggagt cagacttcac 580501 tgtagctggc gttttatcag tttcctcttg ctgattcatt ttctccaatt caagctgctc 580561 tgtttttttc tctgtataat aatcgtaatc tcccagatac tcctctatat ggcttgaaga 580621 aagctccaat actcttgtgg cgattctgtt aataaaatat ctgtcatgtg agacaaataa 580681 cagtgtgcct ggataatcaa tcagcgcgtt ttcgagaact tctttgctgt ctaaatccag 580741 atggttcgtc ggttcatcaa ggatgagaaa gttggctttt tgaagcatca gcttagctag 580801 agccaatctt gctttttcgc ctccgctcag tgaatgaact ggtttcagca catcatctcc 580861 ggagaataag aaatttccga gacacgttct gatttctttt tctgggagcc cggggtactc 580921 gtcccacagc tcatcaagga cacgtttaga ggaagtcaac tcagcctgtt cctggtcata 580981 atagccgaca ctgacatttg agccgtaaga aattgttccc tgatctggtt ttagggtgtc 581041 tattaatgtt ttcagcaatg tcgatttacc tattccgtta gggccgacaa gcgcagcgct 581101 ttctcctctt gtgagcatga atgacacttc tgttaaaagc ggcggctggt tttcatagct 581161 gattgtgaga tcctgaacac gaaggacttc atttccgctc tgttttgtaa tatcaaaatg 581221 aaagtttgcg gatttttcat cgccaagcgg ttttgacatg acatccattc gctcaagctg 581281 ctttctgcgg ctttgcgccc ttttggtggt agaggctctc gccagatttc gatctacgaa 581341 gtcctgcagc tttgcaatct cgtcctgctg cttttcatac attttcagat ctttttcata 581401 ctgcgcggct ttttggtcga gataagcgct gtagttgccg tgatactttt tgctttctgc 581461 tcttgatacc tcgtatacct ggtttactac tttgtccaaa aagtagcggt catgcgaaac 581521 gatgagaatg gcgcctgaat agccttgtaa ataatgctca agccaggtaa gcgtatcaat 581581 atccagatgg tttgtcggct catcaagaat gagcaaatca ggctgtgtta atagaagctt 581641 acctaaagcc agtcttgttt tctggcctcc gctgaggctt tgaacctgtg tagaatcgtc 581701 aaaatggctg aagccgagac catgcagcac agatctaaca tccgcttcat attgataacc 581761 gcctttatct ttgaattcct gctgaagacg gtcgtaggtt ttcatgatgc tttctaattc 581821 acccgggtca gctgccgcca ttttttcttc catagcccgc atttcctttt ccattgcttt 581881 taagtggtca aaaacagtca gcagctcttc ttttatggta agcttagaat ccaagccagt 581941 atgctgggcg agatatccca ttgtaatatc tttcggttta ataatttcgc ccttttcata 582001 cgaaagctgg cctgcgataa ttttaaggag cgtggatttt ccggcgccat ttcttcctac 582061 aatggcgatg cgatcacgat ttctgacttc cagctttata ttgtttaaaa tagtatcagc 582121 accaaatgat ttggacagct gattaacttg taagatcatc atattatttc acctctgcta 582181 taataagtta agtgtagctt atgaaccaga agtcagcaaa caatacattg gccatataag 582241 acatagagaa gaaaatagtg tatgatctgt ttaaggagcg ttttaatatg aatggatttt 582301 ctcattttaa tgaacagggc agagcccaga tggtggatat tagcgaaaaa tcttcgactg 582361 tccgtactgc ggcggctgtt tcaagcgtac acatgaagaa tgaagtgtac gagaaaatac 582421 aaagtcacga tatcggcaaa ggagatgtac tggctgtcgc acaggtggca ggcattatgg 582481 ccgcaaagca aacgtcgaat atcattccga tgtgccatcc gctttcattg agcggggtag 582541 atatatcgtt tgactggaaa ataaaagaag cagaagttat acttcatata aaagcacagg 582601 tcaaaacgaa agggagtaca ggtgtggaaa tggaagcgct cacttctgca tcggtgtgcg 582661 ctcttaccgt ttacgatatg tgcaaggccc ttgataaggg aatggtcatc ggccctactt 582721 tcttgctgga gaagacaggc gggaaaaacg gtgactttaa aagagaacta tccgagtata 582781 atttggagga ccaaaaatga ataaggatca atcaaaaatt ccgcaggcga cggcgaaacg 582841 gctgccgctt tactatcgct ttttaaagaa tctgcatgcg tcaggaaaac agcgtgtatc 582901 atccgctgaa ctcagtgatg ccgtaaaggt tgattctgcc acgattcgga gggatttttc 582961 ctattttgga gctcttggca aaaaaggata cggatataat gtggattatt tgctgtcttt 583021 tttccggaaa acgcttgatc aggatgagat gacagacgtc atcttgattg gtgtcgggaa 583081 cttgggaacg gcatttcttc actataattt cacaaaaaac aataacacaa aaatttctat 583141 ggcttttgat ataaatgaga gtaaaatagg aactgaggta ggcggcgtgc ccgtctataa 583201 ccttgatgac cttgaacaac acgtaaaaga tgaatcagtt gccattctta cagtgccagc 583261 agttgccgct caatccatta cagacagatt ggtcgcatta ggaatcaagg gaatccttaa 583321 ttttacgccg gcccgtttga atgtgccgga acacattcga attcatcata tagatttagc 583381 agttgagctt cagtcactgg tttatttttt gaagcattat tcagttttag aggaaatcga 583441 atagagggaa aggaggagcc caaatatgcc gatcggtcct ggaagccttg ctgttatcgc 583501 aatcgttgct ctgattatct tcggtcccaa aaagctgcct gaattgggga aagcagcggg 583561 agacacactt cgtgaattta aaaacgctac taaaggatta acgagtgatg aagaggaaaa 583621 aaagaaagaa gatcagtaag ttaggatgac acgaatgaaa gtgaatcaaa tgtcgctgct 583681 ggagcatatt gctgagcttc gaaaacggtt gctgattgta gcgctggcgt ttgtcgtttt 583741 ctttattgct ggattttttt tagcaaagcc gattattgtg tatctgcaag aaacagatga 583801 agcgaagcag cttacgctta acgcgtttaa cctgacagac ccgctttatg tgtttatgca 583861 atttgcgttt atcatcggca tagtcttgac ctcgccggtt attctttatc agctttgggc 583921 ttttgtgagc ccgggcctct atgagaaaga gcgcaaagta acgctcagct acattccggt 583981 ctctattttg ctgtttttag cgggcttatc tttttcatat tatattttat ttccttttgt 584041 tgttgatttt atgaagcgga tttctcagga cttgaatgtc aatcaggtga tcggaattaa 584101 tgaatatttt cattttcttc tgcagctgac gattccgttt ggactgctgt tccaaatgcc 584161 ggtcatcctc atgtttttga caaggctcgg aattgtgaca ccgatgttct tggcgaaaat 584221 cagaaagtat gcgtatttta cgctgctggt gatcgcagcc ctgattacac cgcctgagct 584281 tctgtcccat atgatggtca cagtcccgct tttgatttta tatgaaatca gtatccttat 584341 atcgaaggcc gcttatcgga aagcacagaa aagcagtgct gccgatcggg acgtgtcttc 584401 tgggcaataa taaaaaatcc atttctcatg cgagaaatgg attttcttta tttttggttc 584461 tttttgattt taaatgaaaa ggcgaacatc ttaaaagaaa tgctgatgtt gtaagcggcg 584521 aacaccatca gcaggatgga gtaaaatgac cacatgctgc ctggcgagct tgcggcaaga 584581 taagtaaaga tgcaccctac ggcaaagtag atcattcccc aaactaccgg gtttctcata 584641 aaaataatcc tccaataatc aattgcattt gtgtgctctg ctgttcaagg taattacgaa 584701 caggctcaag ctgcatgatg acgacgaatg tattcatcat taaatgggcg aaaatcggca 584761 cccatatccg ttttgttctc gcatataaaa aggcaaaggt aaagcccatt gctgtatata 584821 gaaggagatg cttcaaatca gcgtgaacaa taccgaagat aaccgagctg atcagtcctg 584881 cgaaaaagaa attcgttttt tcgtacagcg cgccgaaaat gatttttctg aagatgattt 584941 cttctaatat aggcccgacg atggaagaaa cgataatcat gagcgggact gcctgaatga 585001 catccagaat cgcttgtgta ttttctgatt ctcttccgat gccaaaaaca taatattcaa 585061 tagagcctgc tattccttga gagaaaaggg caatgaaaaa accggctatc gcccaaagga 585121 tagaaagtcc gattgagtcc ttctgtccgt ttcgcagcgt ttctttcgga acggttctca 585181 gaatgagcag aacaacaacg agacaggcga taaagctgat aacggaccat aatccttgtg 585241 catgcagcat attttcatct gtaggctgtc ctccggcata accgaattta aataacaagg 585301 gaatcgcgat taatgcggaa aactgcatga tgatatatgt caaaataata aaccaatact 585361 gttttctcaa atggtatgta ctcctttgtt aagtgggttt cgttcatcta cagctattgt 585421 aacataatcg gtacgggggt gaaaaagcta acggaaaagg gagcggaaaa gaatgatgta 585481 agcgtgaaaa attttttatc ttatcacttg aaattggaag ggagattctt tattataaga 585541 attgtgttag cactctttag tgctgagtgc taaaattaca tattcatact attgaggagg 585601 ttatttcatt gttaaagcca ttaggtgatc gcgttgtcat tgaactcgta gaatctgaag 585661 aaaaaactgc cagcggaatt gtgttgccgg attctgcaaa agaaaaaccg caagaaggca 585721 aaatcgtggc agctggttca ggtcgcgtgt tagaaagcgg agagcgcgtt gctttagaag 585781 taaaagaggg cgaccgcatt atcttctcaa aatacgcagg tactgaagtg aaatacgaag 585841 gtactgaata cttaatctta cgtgaaagcg acattttagc tgttatcggc taattcttaa 585901 ataaacaata cttaaaacat ttgaggaggt cttgtaaaca tggcaaaaga aattaagttt 585961 agtgaagaag ctcgccgcgc aatgcttcgc ggtgtcgatg cacttgctga tgctgttaaa 586021 gtaactttag gaccaaaagg acgcaacgtg gttctagaga aaaaattcgg ttctccgtta 586081 atcacaaatg acggtgtaac aatcgctaaa gaaatcgagc tagaagacgc gtttgaaaac 586141 atgggtgcta agcttgttgc tgaagtagcc agcaaaacaa acgacgttgc cggtgacggt 586201 acaacaactg caacagttct tgcgcaagca atgatccgtg aaggccttaa aaacgtaaca 586261 gcaggcgcta accctgtagg cgtgcgtaaa gggatggaac aagctgtagc ggttgcgatc 586321 gaaaacttaa aagaaatttc taagccaatc gaaggcaaag agtctatcgc tcaggttgct 586381 gcgatctctg ctgctgatga ggaagtcgga agccttatcg ctgaagcaat ggagcgcgta 586441 ggaaacgacg gcgttatcac aatcgaagag tctaaaggct tcacaactga gcttgaagtt 586501 gttgaaggta tgcaattcga ccgcggatat gcgtctcctt acatggtaac tgactctgat 586561 aagatggaag cggttcttga caatccttac atcttaatca cagacaaaaa aatcacaaac 586621 attcaagaaa tccttcctgt gcttgagcag gttgttcagc aaggcaaacc attgcttctg 586681 atcgctgagg atgttgaagg cgaagcactt gctacacttg ttgtgaacaa acttcgcggc 586741 acattcaacg cagtggctgt taaagctcct ggtttcggtg atcgccgtaa agcaatgctt 586801 gaagacatcg ctgtccttac tggcggagaa gtcatcacag aagatcttgg ccttgacctg 586861 aaatctactc aaatcgctca attgggacgc gcttctaaag ttgtcgttac taaagaaaac 586921 acaacaatcg ttgaaggcgc tggcgaaaca gacaaaattt ctgcccgtgt gactcaaatc 586981 cgcgctcaag tggaagaaac aacttctgaa ttcgacagag aaaaattaca agagcgtctt 587041 gctaaacttg ctggcggcgt agctgtcatc aaagtcggcg ctgcgactga aactgagctg 587101 aaagagcgta aacttcgcat cgaagacgcc ttgaactcaa ctcgcgcagc tgttgaagaa 587161 ggcatcgtat ccggtggtgg tacagcgctt gtaaacgtat ataacaaagt cgctgcagtt 587221 gaagctgaag gcgatgctca aacaggtatc aacatcgtgc ttcgcgcgct tgaagagcca 587281 atccgtcaaa tcgcacacaa cgctggcctt gaaggatctg tcatcgttga gcgcctcaaa 587341 aacgaagaaa tcggcgtagg cttcaacgct gcaactggcg aatgggtaaa catgatcgaa 587401 aaaggtatcg ttgacccaac aaaagttaca cgctcagctc ttcaaaacgc tgcgtctgta 587461 gctgcaatgt tcttaacaac agaagctgtt gtcgctgaca agccagaaga aaacggtggc 587521 ggcgcaggaa tgcctgatat gggcggcatg ggcggtatgg gtggaatgat gtaataaagg 587581 gatattaacc cttatacatc aatgttttaa ccgtcttaaa aaactagaca aagcgtgaat 587641 aaaaaaagag aaggtctttc atcagtttac taaactgttg ggagaccttt tctccatatt 587701 agcggtcata tgagcataaa tgtccatcgt cgtatttatg tccgaatgac caaattgttg 587761 ctggatttct ttaatgccta ctcctgcctc aattagtaag gaggtatggg tatgcctaaa 587821 agagtggggg gtgacattct ttttatccca gcttttttga gcagccgttt aagtctagtc 587881 tcaataacct ttcttaattg cggatgacca tcctcccgct caaaaataaa tgatgagtct 587941 tgataaatca atctattttt aagcttaatt tcattttgat aaattttatt tttttttagt 588001 agattgacat cgtttcatca attcgaacga tatcaacaga tcctgttgtt ttaggtgtta 588061 gcaattggta tttttcaatt tgattgttag gggtgtatag ggtctttgtg acctggctta 588121 tcattgaaat ctgtccattt taaagcaaga agttcaccaa ttcttaggtc ggtctaggca 588181 agtacggtaa agaccaaatg gtccatttct agcccgtcag attgagcgag ctttagaaaa 588241 tgtgtcagca cctctttttc caatgctttg ttgcttcttg ggtaattgaa aatccccagt 588301 tgggttcatt ttaataatcc cttgagtttt agcttttcgg aaaatcatac ggccgcaggc 588361 atgaatacct cccaaacaat tgtgactgta ttgctcgttc agttctaacg tgcggtcttc 588421 atacattttt ttgtgttttg ctaatcgggt attgacccaa tactgcgata aaatgcatca 588481 ttttcttttc actggcccgt acactgctta tttttacccc actccggttg taaatcttaa 588541 gccaaccttt tgcaaatgtt ttgaagggca tatctgactc cttaataaaa gtcccgttgt 588601 cgttttggag ttctacgtga cgggctgcta ctggggcttc tttctttgtt ttaaatcttc 588661 ctttggatat ttctagacgt tttttggtta aagggtcaat gcctagtaga tatgataact 588721 ccacgtctta ccgcattgct tgagttttgc catttatttg tccctaacta attttttttc 588781 atcaaattgg tctttaagtg agtttaataa tttttgtttc tctcgactgg tcaataattg 588841 cccttcatat ttcaaaagat tggataaatt tgagatggaa tcaatcctga tggatggtac 588901 cgtagacttt aataagaaac gaaaggccaa ctgcgacttc agttggcctt tcctatttat 588961 aataaagaaa ttgagtgaga ttgctgacag aactacgtac tactcgtttt ctttagttgc 589021 ccttgctaat cgttcaacct ctccccgaat cccaatcgca ggctcccacg aatcaatcaa 589081 acgaatcgcc ttctgattag attccaccgc tttcgttttc tctcctttac gatacaacag 589141 ctgcgccatt ccgtagtgat agtagatcag ttcaacttga ttggcgttat gtttgtcata 589201 gagcatttgc tcaaaggctt cttccgcttt ttcaaactga tcacatttca cgtaagcgac 589261 acccagattg aaataggctt ctatcgtttt ttcgccgccg tatgtggagc tgatttcatt 589321 tgccgcttcg tataattgaa tggcttctac atgataacct ctcgcaaagc ttaagtcacc 589381 gcgaaccaat agaactctgt gttgaatggt aggggaaatc ggttgatttt cgatttcgtt 589441 taaaattgtc tctgcttttt cctgttgccc gtcttttaaa aacagccttg ctttgagtgc 589501 atgtccccaa acctttagat cataggcatc gtgagcgtct gattgttcaa gaatcttcag 589561 cccggcttct atttgctgaa gcgctccgtc taaatcattg acttccatca atgcccagcc 589621 tgaggtgtcg attcggaagt acgcttctcg tgtgtgttgg cctaagtgat gggcggcgtc 589681 ggccgctttg cgtccgtatt cgattcgcag gggcaggttg attctgctta gaaaatggct 589741 aatgcgggtg atgagttcga ttaggatttc tttttgttca gtttcacttg cccattggat 589801 gacctttaag atgtttggcc attcttgttt catttgatct aagttccgtc ccagcaggta 589861 gctccaatag atagagttgg gctgttcccg ctttaaatgg gtttcggcat aatcaatata 589921 atagtgcgcc cagcgattgc gggcttcttt ttcatattcg tgctgttcgg acaagtgctg 589981 ttctccgtaa gcgacaacgg tttggtgcgc taagtattgt gtcctgcctt ggcttcgttc 590041 cggctgaatc agcgcatatg accgcatttg ttccatagcg taatgaaaac ggcgggcgtc 590101 taatccggct gctgccgcca ggcttttttc atcaggcggc ttgctgaaaa agcaaagcgt 590161 ctgccagagc tttcgcgtat cttcattgca tctatcccag gtgcggccaa agaggaattc 590221 aaacaattcc agcagtgagt agcctgcttt tccaagctca tgaatcagct gctgagcggg 590281 gatgtcatcg tctgacatat aggcaatgct gagtgccatg gctttcgggt ttccggcagt 590341 cgctgaaatg aattcgtttt tcaggtcaga tgatagatgt aacagctgct ccagcttttc 590401 ccgtttacgt gggaggttgc atgtttgtaa gcagtgatgc acttcttgtt gaaaaaattc 590461 gtgggcatct gtttggtcaa gaccgcttag ctgaatggct gtcatttctc cgaagctttc 590521 ccgataagtt tgctttacgt tttcccgcgc tgtaaggaga acttttacgc cttgcggaag 590581 gctggtgata aattcatgaa tgtcacgttc tgcagtatca atgctgtcaa cgatcagcag 590641 gatcggtttt tctctagtgt aattggctaa cgcattgcgg acgacaaacc gttttacatt 590701 gattgattta tcgatttgtt ctttgcgtcc gagctgatag gcgatcgtat ttaaaaaatc 590761 gctaaagctt aatcctttcc aatcagcgct gacccagatg atgctgttga atgccggcca 590821 aactgaagta tcgtcgacac aggaataggc ggcttcaaga gcaattgtgg tttttcccat 590881 gccggcccag ccggtgatta aacagactgg tgatggagaa agcatccatt gccgtatcgc 590941 ttccatatca aagctgcgtc cgataaagcg tccggaccag cgtgagggta aattatgcgt 591001 gatgggctgt tctgtaagcg cattcgtttc ttggccgggt ctgtcatgaa acagccgttt 591061 tactacattt tcaatttcgc cttcactcgg agccccgaat aatccgtctt ttcgcagtat 591121 tttcgctttt ttcaaacagg atgctgccca tacaggcaat gcgggtttga tgactgggat 591181 agtggtggct tccagcaagt cggtcaacca ctcgatatcc aagtcggtct tttcgagaat 591241 gatccagatc attccgaaca gttttccgtc gtcgattctt ccgggaatgt agtttgcccc 591301 catctgtccg atccagcttt tgatcgtgtt tggggagact cccagctgga gtgcgatttt 591361 atctatgtaa gactgtcctg ttttttcatt ctttttcctt ctgactttat aatcaggatg 591421 aagttttagc gttttgacgc caggtgccag catttgtgca aattgttttc ggttttcaag 591481 ttcagccata agcctgcacc tcctattagt actattttat caatccagcg ttttttgtat 591541 atgaaaaaat aaaagtacag tgccgctgtc cttttataca gcaggaaagg ctgttgaacg 591601 tgttaaaaag cagataaaat gggggcagta acagagaaaa caaaaatgta tgcacttaca 591661 ttttattttc taaagaaagg aacttgccaa atgactcaca cagtacctca aaacatgaaa 591721 gcggctgtta tgcacaacac aagagagatc aaaattgaaa cattgcctgt gcctgatatc 591781 aatcatgatg aagtgttgat taaggtgatg gctgtcggaa tttgcggatc tgatctgcat 591841 tactatacaa atggccgaat aggcaactat gttgtggaaa aaccatttat ccttgggcat 591901 gaatgtgcgg gtgaaattgc cgctgtcgga tcatctgtcg atcaattcaa ggtgggagac 591961 cgcgtcgctg tagagccggg tgttacgtgc ggacgctgtg aggcgtgcaa agaaggacgc 592021 tataatcttt gcccggatgt acagtttttg gctacaccgc cggtagacgg tgcgtttgtc 592081 caatatatta aaatgcgtca ggactttgtt tttttaatcc cagactcact ttcttatgaa 592141 gaagctgctt tgatcgagcc gttttctgtc ggtatccatg cggcggccag aacgaagcta 592201 cagcccggat caacgattgc gattatgggg atgggccctg ttgggttaat ggctgttgcc 592261 gcagctaaag catttggggc aggcacaatc attgtcaccg acttagagcc gctgcggtta 592321 gaagctgcga aaaaaatggg agcgactcac attattaata tacgtgaaca ggatgcactt 592381 gaagagatta aaacgatcac gaatgataga ggcgttgatg ttgcttggga aacagcaggg 592441 aatccagcgg cattgcaatc cgcactggct tctgtgcgcc ggggcggaaa attggcgatt 592501 gtcggtttgc cttcacagaa cgagattccg ctcaacgtgc cgtttattgc ggataatgag 592561 attgatattt acgggatctt ccgttatgcc aatacgtatc caaagggaat cgaatttctt 592621 gcttcaggca ttgtggacac gaagcatcta gtaacggacc aatattcgct ggagcagacg 592681 caagatgcga tggagcgggc gcttcaattt aagaatgaat gtttaaaagt gatggtgtat 592741 ccaaatcgct gagtgaacag ggaggatctt cgtattctcc ctcttgttta ctggaaatga 592801 aaacggattc ttggggtggg aaatgatgat tggaacagaa aaagtaacgg cattgaaggc 592861 gaagcatcag tcaaaatcca gcaccggcct gtcctggttt gaacgaatcg gttatggatt 592921 cggcgatatg tcgtataata ttatctttca gtttgtaaac gcatacttat tattttatta 592981 tacagacgtc ggcggcattc agcctgcggt aatcgcaact ttgtttcttg ttgtgcgtgt 593041 gctggatgct atttttgacc cgatcatggg attgatttta gataaaacga atacaaggtg 593101 gggaaaagca aggccatatt tgctgtgggt ggcatttcct tttgcgctat tcacattctt 593161 atgtttcacg acgcctcatt tcggtgagac cggaaatatg gtatatgcgt atgtcactta 593221 tattctgctt gggatgtcct ttagtatgca aacgatcccg gtgaacagct taacggggcg 593281 gatgacgaat tcggtggagg aacgaacggt tctgaccaca acccggatga ttttggtgta 593341 tatcggcatt cttttatcca tttcctgtgc gacaccgctt gcaactgcta tcggaggaga 593401 ggatcaggcg tttggatttc agatgacggc gctcatctat gcggctgtca gcatcgtttt 593461 gaatctattt agtttcttta ctgtacggga gcggattcag cctaaaaaga gaaaaaaaca 593521 agggatcaaa aagacgttat ccgttttatt caaaaacaaa cccttgctca tgttaatttc 593581 atcatttttg gcttttgcga tcgggtttaa tattaagctc agcacgatgg tgtattattt 593641 tacgtataac gtaaaccata aagagttcgt gtttatgggc accgttttat ttttcggggc 593701 agcgctgatc agcaatttgt ttattccttt cttttctgag aagtggggca gaaaacaagt 593761 catgattatc acggcagctc tatcgcttat ttcttatgcc ggcctgcatt ttacgccgta 593821 ttcttcaatt ccactcattt tcatttggct tttcgcttcg ggatttttca caacgccttt 593881 aaatacgctt gcttggggaa tggttgcgga ttgcgtcgat tatgcggaat ggaaaaccgg 593941 aattcgcgcg gatggtgttg tgatttcgag catgagcttt attaataagc tgggtgttgc 594001 gttagccggg tcattttcgg ccatttattt aggaatcgcc gggtatgtgg cgaatacaga 594061 ccagacagtt gcgtcgttga atgcgattaa aaatatgaat gctttgattc cgggattttt 594121 cattttgctt tctattattc ttatcgcctt ctatccttta acggaaaaaa gatataaaca 594181 catcatctct gagctggagc aaaggtctgc gagataaata gatgtaaaat ttttaatatt 594241 caatgttgta tttatggcaa aaagtaatat actgagactg taatctagac tttataaatg 594301 agtgtgataa tatgcgtagt cattctgtag tttgtattgg ggaattgttg attgatttct 594361 tttgtaccga tgttgacgtt gatttaatgg aagggcgcca attcctgaaa agtgccggcg 594421 gggcaccggc gaatgtgtcg gcagcgattg ccaagctggg cggagacgcc gctttcagcg 594481 gaaaagtagg aaaggatccg tttgggtatt ttctgaagcg aacattggac gctgtacatg 594541 tcgatacctc tatgctggtg atggatgaga aagcgcctac aacgcttgct tttgtttcat 594601 taaaacaaaa tggagagcgt gactttgttt ttaatagagg cgcggacgct ttgtttacgc 594661 tggaggacat tgaccaggaa aaactaaacg aagcgaaaat ccttcatttc ggctctgcga 594721 cggcactgtt atcggatccg ttttgctcag cctatttacg gttgatgtcg attgcgaaag 594781 acaatggaca gtttatttcg tttgacccta actaccgtga agatttatgg aggggaagag 594841 tctcagagtt tgtaagtgtt gcgaaaaaag cgatcgctgt aagtgatttt gtgaaagtca 594901 gtgacgagga acttgagatt atcagcggtg tgaaggatca tgaaaaggga gttgcgatcc 594961 ttcatgagat cggagccaac attgtcgctg tgacacttgg gaaaagcgga acgcttcttt 595021 ccaatggaaa agaccgtgaa atcattccaa gcattccggt gacatcaatt gactcaacag 595081 gggcgggaga tgcttttgtc ggtgcggctt tatatcaatt ggcaaacacg gatcagattc 595141 aatctgtaga tgctgatttt gtgaaactgc gtgagattgt ggcgtttgcc aataaggtcg 595201 gagctcttgt gtgcactaaa attggagcga ttgatgcact gccgagtttg gatgagattg 595261 gagtttcttt gtaaatcatt gaagatgttt cttgaaagtc tttggacttt tgggggcatc 595321 tttttttatt gcttacattt ttgttcaggt aaaaagttgt atattttttg tttgaaatgt 595381 cattttttat taaaaaagtg aaacttttaa cgataataaa tagtatatgt aacaagggtt 595441 accgaattag ctttaggagg aacgatataa tgagtataat tggaagattt aaagatatta 595501 tgtctgcgaa tatcaatgct ttattggaca aggctgaaaa tccggagaaa atggtagatc 595561 aatatttaag aaatatgaat agcgatttgg ctaaggttaa ggcagaaaca gcagctgtta 595621 tggctgagga gcagagagca aaaagagaat atcacgaatg ccaggcggat atggaaaaga 595681 tggaaagcta tgcaatgaag gcgctgcaag ccgggaatga gagcgatgcg agaaaatttc 595741 ttgaaagaaa aacatctttg gagtcaaagc tttctgagct gcaggcggcg aatcaaattg 595801 ctgcaaccaa tgccgcacag atgagaaaga tgcatgacaa attggtatct gacattggag 595861 agctggaagc acgcaaaaat atgatcaagg cgaagtgggc agtagcgaaa acgcaagaaa 595921 gaatgaacaa actgggcgct tctgtttcaa gtacaagcca atcaatgtct gcattcggcc 595981 gaatggagga caaagtaaat aaggcacttg atcaggccaa tgcaatggct gaactgaaca 596041 gcgctccgca ggatgatatg gctgatctgt ctgcaaagta tgacactggc ggttcaagcc 596101 aggttgatga tgaacttgcg gcgttaaaag cgaaaatgat gctcgataag taatacatag 596161 gaggccgcag ctttcggctg cggcgtcatt ttatcataaa atgtgagagg gaacggtaat 596221 gataatatct tataagtgtc cgaactgcgg cagtgatatg gcatttgaca gtgaaaccgg 596281 ctcgttatcc tgcagcagct gcggaagaca ggacaatatt gaaagccttc cgaaagaaaa 596341 cattgcggca cggttttctg atgatgaagc aaaagaatat caatgtaaaa actgcggtgc 596401 cgttttgatc acggaagctg aaacgacagc aacgacgtgc agcttctgcg gaggtgctgc 596461 aatacttgcc gatcgtttat caggacattt ggcgccggcg aaggtcattc catttacaat 596521 cagcaagcaa gaagcggagc aggcatttcg aaagtggtgc aaaaaaggcc ttctgacacc 596581 aagaggtttc atgtctgctg atcgtatcaa aagcatcacc ggcatgtata ttccattttg 596641 gatgtttgat ttaaatagtg aagtacaggt gagagcaaac tgtaccagag tccatcaata 596701 tgaagaaggg gattatattt gcacggaaac agagcacttt gaagcgtttc gtgatatcaa 596761 tctcgattat ttgaaaatcc ctgtcgatgc ctctgaaaaa atgaaagacg aattaatgga 596821 caaattggag ccttattcat acgaagagct gaaggacttt caaacggcat atttggccgg 596881 ttatattgcg gaaaagtaca attataccga tgaggagctt tttccgaggg caaaagagaa 596941 aatcagcagt tatatagatt catacatcca ttctactttt tccggatata cgtcagtcaa 597001 tgtgagggac aaacatattc acacgaaaaa cgtgaacagc ttttacgttt tgcttcctgt 597061 ttggatggtc agttacgatt atgaaagagc ggagcatatc tttgcgatga acgggcaaac 597121 aggaaaggtc gttggaaagc cgccgatcag tcgaggaaaa gtggctgcat ggtttagcgg 597181 aatagcaggc gggacatttc ttgcgttgaa gctcgtctca ttgatgatgg gaggcggatt 597241 ttgatgcgtg gattttttgg gaaagcgatc tttgttgtgc tggctgtttt catcatgatg 597301 cctttactgg gtatcgaagc ggtaagagcc tctgaattgc agcagcatgt gtacgatcgc 597361 gctcatctat tgtcaaaagc ggagatcgga aaacttgaat ctctctcggc aaagctgggt 597421 gcaaagaggg acactgattt catcattatt acgaccaaaa gcacaaacgg tgaagatatt 597481 gcagactata ccggcgattt ttatgatcgt tacggaaaag gcagtacagc cattctgacg 597541 attgatatga caaacagaga agtgtttatc gcaggcttta aaaaagccga acagtatttg 597601 gacaacagca ggctcaatag catcagaaat acgatttcat ctgatttatc caatgaaaat 597661 tattttgaag cttttgagac atatattcag ctttcctata aagatatggg cataaaaccg 597721 ggagtaaacc ctgacaacat attctttaca tggtggtttc agctgattgc tgccatcgca 597781 gtcgggggaa ttgcggtttc aatcatgctt tatcatgcag gcggcaaagt aacggttaat 597841 ggaagtacat atatggatca gcgtacgtct gatgtgattg atcaatacga cacttatatt 597901 agaacgactg taacaagaga aagaaaacca tcagataaag acagcggcag cgatggcggt 597961 gttacgaaag gcggcacgtc atacagtggg agccggggca gtttttaaat gtaagaaata 598021 gagaaaggga gaggcgtaat gtcgtttttc agaaatcaat tagcgaatgt agtagagtgg 598081 gaagaattta gagatgatat gattttttat aaatggaaca atcgtgaaat caaaaaaggg 598141 agccgtttaa tcattcgtcc cggacaggat gctgtctttt tgaacaatgg gcgggttgaa 598201 ggagtctttc aagatgatgg cgattatgat attgaatcag aaattattcc attcctttca 598261 acgttaaagg gctttaagtt tggctttaac agcggcatgc gagctgaggt gctgtttgtc 598321 aatacgaagg aatttaccgt aagatgggga acaaaacagg cgataaatat tccggcagcg 598381 ggaatgccag gcgggatgcc cattcgcgca aacggcacat ttaatttcaa ggtgcaggac 598441 tatatcagcc tgattgataa aatcgctggc gtgaaagatc aatattttgt agaggatatt 598501 aaaacccgta tcatttctat tctggatcag cttctcatga agtggatcac aagagaaggg 598561 aaagatatgt ttaatcttca agcaaacgct tttgatattg ccaagggaat tcaagaggac 598621 ttagatatgc aattaataag cgacgggatg acggtcactg gttttcaaat catgagcttt 598681 aattatcctc aagaggttca agatatgatt acaaagaacg cttcctacgg tatggttggg 598741 gatgtgaaca gataccagca aatatcaatg acggatggaa tggcatccgg aaagatgagc 598801 ggaagcggag cggcttcgga tatggctgga atgatgatgg gaatgaatat ggccaatcag 598861 atgatgaacc aaatgaatca gaatcagcag gcacagtcat caggcccaca gtcaactggc 598921 agcggaagca aaccgaattt ctgtccaaac tgcggaacaa aaacgggcga agccaatttt 598981 tgtccgaatt gcggccagaa gcttgtataa gaatcataca gtgaaaagtc cggagtgatc 599041 agcactcggg acttttttat ttaggagaat aagcattacc tattgcttgc tcctgaacag 599101 gccattttcg agcccccgct tggataattc ccagcagcaa ttgacgacgt tcctttattg 599161 aattgacggc aatttgaaat gtttgctttg ataaagccgg tatgcctgat tgttgaagct 599221 ttgagatgtc tggttctggc ggcgcttgtt ctgcaggatg gatataggca gtatgaacgg 599281 tatccagata gtttttgata cttgagcgcg cttctttgat atgaagctga ttcggctgat 599341 attgttcagg aattccgtat ttgaaaatgg ttagagcctc atccaataca gcaacagcta 599401 taatggatga ttcctgatgc tgcgtgctgt ggtaaaaatg aaggatgggg aaggcgttat 599461 gctgagcggt cagctttccc agttctgatg aggcagcgac aagaagaaaa tcaatgtcgt 599521 gaaaatcttt gccattccat gcattatgga cgatttcagt tccgtcatgc cctagactta 599581 atacactttg ggcaaaggag cgtttttgat taaccgcact caagacggaa atcaaatacg 599641 tgacagaaaa tgtgatggta agcagtcctt gagctgtttc aataatcgtg acaagcttcc 599701 ataggcctcc gttcggagcg aggtcgccat ttcctaatgt aaacatgaca tagccggaaa 599761 aataaattcg gtctgaccag gaagccggtt cttttgattg agtttccata agtgagtgag 599821 ggtcactcga gtaaatcaaa acccacccgc tccaaaatag actgatccat atcactaacg 599881 tcaggcataa cagcagagga ccagccatac ttagaacctt tgcgtggtca ccgctgattt 599941 tgcggcagcc cttccacagc caggcagaca ggcatcttgt gatcgggccg gcaccgctct 600001 ctaaccataa cgtggtccat aaaaaatcaa tcatccccgc tgtcaataat aaaaggcctg 600061 caatgatata accctcattc attttggttg cctcccttaa gtcagccttc ttttattttc 600121 ttctctattt ccttttatcc tgagtctgaa acaattgaac gaatgtttga ttttacagag 600181 aaaaataggt gggagttacc caacacttac tcatttttca atatgaacag aaaatcacaa 600241 gatttttgac ttgattcaca cattttcatg aagaaaaacg ttcattttcc ccttgaattg 600301 gtgattttcc ttttatagag taaaaaattt tcagaaattt atattgactg aaagcgtttt 600361 tataattatg ataatatcag atataacaaa aatgtcacta taacatcact acaattgaac 600421 tattaagtga ctaataaata ccaaatgaac gaggttatgc acaaagaaat gaccattgtt 600481 cttttaacga gaaatgaaat cgcttccata gggattgaca tgctaagaag aagggaaggt 600541 tatgaggtta ttggataaaa acatgaacaa ctattttctg aagcctgctt acgaaatgtg 600601 aggaaggcag cagccctgga ataagttttt gacatacgca ttttgaaaaa gactggggga 600661 aacagtatga ataaacaagg aaatcaaatg tcatttttac gtacaattat tttagtctcc 600721 actttcggcg ggcttctttt tggctatgat accggtgtgc tcaatggagc tttgccgtat 600781 atgggagagc cggatcagct taatctcaat gccttcacag aaggccttgt caccagttca 600841 cttctttttg gagcggcact gggtgctgtg tttggcggca ggatgtctga ttttaacggc 600901 cgccgcaaaa atattttgtt cctcgctgtt atatttttta tttcaacgat tgggtgtacg 600961 tttgcaccaa atgttacggt catgattatt tcccgttttg tgctcggtat tgcggttggg 601021 ggtgcatccg taacggtgcc tgcctattta gcagagatgt ctcctgtgga aagcagggga 601081 cggatggtga cgcagaacga attgatgatt gtatcaggac agcttttggc ctttgttttt 601141 aatgcgatcc ttggaacaac aatgggagac aactcccatg tgtggaggtt tatgctggtc 601201 attgcgtcac ttccagcctt gttcctgttt ttcggcatga tcagaatgcc cgagagtccc 601261 cgttggcttg tttctaaagg aagaaaagaa gatgctttgc gtgtattgaa aaaaatcagg 601321 gacgaaaaac gggcagcagc tgagctgcaa gaaattgaat tcgctttcaa aaaagaagac 601381 cagcttgaaa aagcgacatt taaagatctt tcagtcccat gggtgcgccg tattgtgttt 601441 attggattag ggattgcgat tgtacagcaa attacaggtg tgaattcgat tatgtattat 601501 gggactgaaa ttctaagaaa ttccggtttc caaacggaag ccgctttaat cggaaatatt 601561 gcgaatggcg tgatttcggt attggcaaca ttcgtcggaa tctggctgct gggaagagtg 601621 gggcgccggc cgatgctgat gacaggcttg atcggtacga caacagcatt attgctaatc 601681 gggatattct cacttgtact tgaaggatca ccggcacttc cgtatgtagt cctgtcatta 601741 acggtcacat ttcttgcttt tcagcagggc gccatttcac cagtgacttg gctgatgcta 601801 tctgaaattt tcccgcttcg ccttcgcgga ctgggaatgg gtgttacggt attctgtctg 601861 tggatggtga attttgcagt cagtttcacg tttccgatat tgctggcagc tatcgggctg 601921 tccacaacgt tctttatctt cgttggatta ggaatttgct ctgtcttgtt tgtgaagagg 601981 tttttgccgg aaacgaaagg gctttcgctt gagcagctgg aggaaaactt ccgcgcttat 602041 gatcacagcg gggcaaagaa ggattctggg gctgaagtga ttggataatt taaaaaagaa 602101 tccgcacccg agtgcggatt ctttttggtt tcaaattagt taggtctaac aaggattttg 602161 acttggcttt tctctttaat aagagccccg aagccttcct cgatcaaatc atctagtacg 602221 atttttttcg ttacgagttt gtcggctgag aaatagcctt ctttcattaa tgacaataca 602281 gccgggaaga tgtcgcggta tccgataatt ccttttactg tacgttcttt gattacgata 602341 tcgttcggat ggatttcagc acctttttcc caaatgctga cgatgacggt ttcaccggca 602401 attgtagtgg actggatggc ttgtcgtaac accactggga caccagtgac ttcgaatgct 602461 acgtcaacac cgcctcctgt acgttctgca atctcagcga ctacatcgtc tgttttagac 602521 ggatcaacga tgatcgcgcc aagctcctca gctttttgct ggcgttcagg agaaagctca 602581 acagcgtaaa tatcagttgc accggcagcc ttcagcgctt caatgacaag aagtccgatc 602641 gggccgcagc cgaatacagc cgctttgtcg cctgctttga gtttgcttga gcggacagcg 602701 tatagagcaa ctgcagaagg ttcaacgagc gcgccttgtt catatgataa ttcatcagga 602761 agtttgaaca aaagctcttc atccacagag acgtattcag agaaaccgcc gcctccgccg 602821 gctaagccga ggaatcccat ttgttcatca aggttgtagg cgccttggtg gccgtgtgta 602881 gcaaaaatcg gctcgactac aacgcggtct ccaactttat aattttcaac gccttctccg 602941 acttcgacaa cttcaccgga gaattcatgc cccattgtga caggtgccgt ttcatttgtt 603001 aatgggtgcg gtttgtcaac cggaataaag atcgggccgc ccagatattc gtgtaaatca 603061 cttccgcaga tgccgcacca tttgactttg atctttactt ttcccggctc cgtttttggc 603121 tcttcgatat gttcaatacg gatatccttt tggttatgcc atcttgctgc cttcatggat 603181 taccactcct ataacttttg atgtgagtaa ttccgcaccg gtcaatatga actgttcaca 603241 aaatcgccat ttttaaaacc aaaaaagaaa tgaaattttt atataatata atctacgttt 603301 ttttgaaaaa aagaaacttt aaagaaaaaa gggtctcgca cactcttttt tctttatatg 603361 agagtatcaa tcgtttacat agctatgaat ttggtttgaa caatacggta atggttcgtt 603421 catattgaat gcgacaacta ctctatcaat aattataact ctaatactgc tattataata 603481 ggataatctt ccatggttta ttttagcaga ggtaactttt ttgactttgt aacattactg 603541 taaggatatt gaaataaaaa atagctggtt gatcgtgtat aatcttccta gatgttaaca 603601 aacaggggga cgaaatgttg aagaaagtca ttttagccgc ttttatctta gtaggaagta 603661 ctttgggagc ttttagtttt tcatcagatg ccagtgcgaa acatgtgaac ggaaatatta 603721 cttggtataa tggagtcggg aaaaaaggct cttcaggtaa gaaacttgga cattgggatt 603781 gtgcgaccaa aatcggattt gatgttccta gaaacgggac aaaaatcaga gcttatgcaa 603841 aagcgaagcc taaaaaggtg attacggttt ataaaaatga tgttggcaga atgcctaatg 603901 cagtgctgga tgttagccct aaagcgttta aagcgcttgg atacccatta agcaaaggta 603961 aagtagcggg gcattacagc tattaatgta catatataat ctggaaagca agaagtcaca 604021 ttcttgcttt ttctattggt ggagataaaa gatgaaaaaa agaatcatat tattattagc 604081 agtgataata gcggcagctg ccgcgggggt tgcgttttat gttgcaaagg ataaaggcca 604141 tgagaaggct gctgatgttt cagtcaatac cgaaagcggt gatgagctgc tggtttcaat 604201 tacagatacg gatctgctga caaagtatta tgaaaatgac aaggtgatcc atgaggagaa 604261 gctgaccagc tatccggcat ttgccttgga tcaaaaacag caggtgctct attatacggg 604321 caataatgaa cagaatgaaa tgaggctttt taaattggat ctgaagtctc ataaaaaaac 604381 gatgctttat aaaggcgcgg agagtgcgga cagtttattt ttatcaaagg accgttcaac 604441 catctatttc cgcttaggaa aagcggacga aagcaatttt cgaatcgccg cttttgatct 604501 gaagacgaaa aagtataaaa atctttatcc tgccgctaat gatcaggatg acaccgtcag 604561 cagcttcttt tataaccaaa aaaacgattc atttgcattg cttcattatt ctgtagaaga 604621 agactacaag aaaacagatg aagcaaacga aaagggcatc gaccctgaac cgacaacgat 604681 tcattttgcg gaaggccgcc aaaataaatt taatgagctg aaaagcctga accaatttat 604741 cagcgatatt gctgtttctg atgatgataa acgtatttta ttcacatcat atacgcaaaa 604801 aggaacggag caaaccgctt ctattcaaat gctcaatgcg gatacgaaaa aatatgaaag 604861 catcatctca aatcaaaaat catttaagct gttaattgac gcacagcctc agttttctaa 604921 ggatgggaag aacatttatt ttcttgccga agccaagggg gctaaaaagc tgaaggacga 604981 aacagggcgt gaagctaagg tgcggacgat ttattcctat agccttgaga ataagacctt 605041 caaaaaagta tgggaaaatc cgaacggcat catcaacagc ttttttgtga ttaactaata 605101 aaaaccactc ggcatgagct gagtggcttt tttaatggat gaggtgcagg gctaatgatc 605161 cgagccattt aaagatatga atcagaggta ccgacaaaaa cagaagttca acatatgagt 605221 tcattgcaac attcagcttt ttgaacgcag ctcttttttt caagtctttt tgctgctggt 605281 ttgagatcac gttatcactc ctcttatatc catattatac cattaaaaca gacaaaaaag 605341 ccctaaacgt ttacagtttt gggcttcttt cttcgtattt ggcctcttgc aatgagaggc 605401 ttttattctg aaatatagaa ttttgtctcc gttcggggtt tgtttgcttg cgggagactg 605461 catttgttat agggaagaac tagcttgttt tcgtttggct gttgttttgg agattcacta 605521 atgaacggat gccgtcgacc attttacttc cgcacaaagg gcacaatggc gtatcactgc 605581 tggcgaagtt ttttcgggtc cagccattac agtcttcttt tgtgcattcc caagtactca 605641 catcttcctt tggcagcggt tcttgatttc gtttgttata gtaagacata aagtcacttc 605701 ttccctcatg tattttactg cacatttcct attgtctcat acttttccct aatctcctaa 605761 ttcctttttc tttatgactt tccaataacc ccatctaaaa aggagaggag tgtgctgtta 605821 aaagcatctg gctcttctaa aaacgggcaa tggctgcttt taggaaaggt aacgagtgtc 605881 gcgtttggaa tattgctgcg caagtgttcc ccagctgctg tagagaaaaa tttcttgtct 605941 tccccgaagc acagcaatgc cggcacattg atgttttgga gggtgccccg gtaatcagcg 606001 gccgtttggt taaataaaat cgtgctagaa atggcagccg gctgtttgag gatttctgcc 606061 agcatccatt ctgtttcggt ctcggcaggc ggttctgcga acatattctg gatgaagctt 606121 tcgtagaaag gcagcgggtc agtttgaatg gcgtgcatcg ctgtttttaa gccgtcaaaa 606181 tcaaatggac catgttccca gccctcccat tgatagtccg aagcggattg atcgatgatc 606241 acagcggctt gaatgttatc attcccaaac tgattgagat aatcccatac gacaaaagca 606301 cccattgacc agccggcaag aacgacatga tcaagctcca ttgcatttag aaattccctt 606361 atgtcacggg catattggga aatggtgtgg ccgtgaagca ctttgtcaga ttcgccgtgt 606421 cctctaagat caagacgaat acattgataa ttggcagaaa gcaccgaaaa ttgtttgtgg 606481 aaaaattgtc cgctcatcag caccccatgt ataaacagga tcggcgtccc gctcccgtgt 606541 gtttcatagt aaaggcgtgt ctgatcttct aatatgatgt atggcatgtt tctcctcctt 606601 tagtttccat catgagtatg gctggctgct gttgagctga tgatggcagc tgtcgcggct 606661 gcctgctgcg cttgaatgac tgtttcgata gcggtgtata gtcctgattc catcagcaga 606721 tttttctcca tatgctcact gagatagagg ctgacagcaa ttttaaagtt catttccttt 606781 tgccatttaa aagctttttc ctggtttaat tcgtcagtga tgcacaaaac ggttttgata 606841 tctggctctt ccagaaatgt gaggagagca aggtctggat aatgataatc ctttgttttt 606901 ttgacagatt cagtgatcga ttgatatatc tgtttgcaag cggaaacaag catttcgggc 606961 tctttttcac tttgcaaggc cagaatatgg ctgacctgat gtaagtactg tcctttttta 607021 aagccgttgg ctgccagcag ttgatagcat gtttccgcct tctgtagcgc ctgcaaacct 607081 tttccgtttt ctccaagcag tacggcaagc ggaacattct gagttgaagt gaggaaataa 607141 tgatttttct tcatctgctg ataaacagct agccccatgt tcatctgttc tttttggttt 607201 gtcgtttcag atttgccggt gagcaagatc agagcggaaa ggtatgtgaa catatcccgc 607261 ttatacccta gcttcaccat ttcattgtat acatcgatga aagtctgaaa tgtttgtttt 607321 gcctcatgct gaaaatgaat gtccagaata gatgcaacag taaagcggtg gtgtgaattg 607381 agtgttgaga agctgccgat gtttgatttg atatagctgc tcaaatcata aaagcgctga 607441 aaatcaaact ctcttttatt cacaatatat gcagaagaaa tgagcattaa tatctgatcg 607501 tgtgaaactt tccattttaa ttttgttttt aattcagcat aaatggaaat gtaatgcttt 607561 gttttttcat gtagatcgtg tgtgagcata aaaagcagct ccttttgttg tttttacgta 607621 atacgataaa tagggccaaa ggtttcataa agaaaaaact tgcctgctag aggcaagttt 607681 gtcgggttat ttatggggat cagttatatc catcggtctc atcatgtcat agtcttcatg 607741 ctctagaata tggcaatgcc atacgtatcg tccgctgtac ggaccgaatg tcgccgcgat 607801 tctcaggact tcacctgcat gcgcttgaat ggtgtctttc cagccctttt cacttggcgg 607861 cggcgggaca gccggaccgg tataggacaa ttccccgctt tcttgataac gggcgatatc 607921 aaacggccgc cggtctaata cacggaagga gactagatgc aggtggatcg gatgtgttcc 607981 gcgtgtcggg ttgataatgg accatatttc agttgtgccg acttttggtg tttctgtgac 608041 gggatcgtgc cagcgtttgt tattaagcag aaggacgggt ctgccgtatt cgtcctgggt 608101 gcctgccagt tttaacgttc tgatgttttg tattctttca tgctgtaccg aagggtatga 608161 ggcgaggtac ttcggctttc tgctttcgtc tttttgtgcc aatggttttg tgactctgaa 608221 ttgcatgata ttcgcatctg tttcaggatt gacgtcaccg ccgcagcccg cgctgtttgc 608281 caaaatgatc gattctcctt catatgctgt gaagtcaatg atgatatcgt aacgttcagc 608341 aggcgcaagg ctgaaagaat tcagtttaac agatcgcggc aggagccctc catctgaacc 608401 aatctgaata aaatctccgc cattatcgag tgacaggtta taggttcttg tattggaggc 608461 gttgatgaca cggaatcggt atttccttgg ctcgacttcc aagtatggcc ataccttccc 608521 gttgacgagt atggtttctc cgcaaaaagc cggaacgatt gaaggattag gcagtgacgg 608581 agaagggttt tccggtgcgc tcggataaaa caaagaacca tcctcattga tcgtgcggtc 608641 tgtgataaga agcggcacat cgtattcgtc tgaaggcagt tttaagcgtt tttcctttgg 608701 gtcatgaatg atatatgcac cgacaagtcc ggcatagaca tttagcctgg tgagcgccat 608761 ggcgtgatcg tgataccaca atatagcccc gcgctgctgg tttggataat gataaacctc 608821 tcttttgaaa taaggtcctg tttgttcaaa gtctttggaa aaccaagcct ccggataccc 608881 gtcactatca tctggcgtga cgccgccgtg taaatgaaca acagtcttta cctcgggctc 608941 ttcatgctgg ctgtcactgt gatgaatggt gtgatcaatc ggaaggaaat gcgtggaagg 609001 aaggttattc atccatttta catatacgtt ttcatttctt ttaacctcaa tggtcggtcc 609061 cggaaataag ccgttgtagc cccacaggcg ggttggaggg agatcgcgat ggagctgatg 609121 agtgcattcc tccatggtga cttcgtagta tgttttttct tttgattgct gtactggctt 609181 tagtgtatct gggattggga gagcatccac aaatttttca agtgtcattt tcatctgtcc 609241 ttatctaaat tttccaaatt ggtactatag ttaatgacaa taaggacgtg atggttacaa 609301 aaaatcttcg tgctgcagcc cgcccgaaga agaaaataac aaaatcctaa acggcaggcc 609361 gtttaggatt tgatcagcat taaggcagga tatcgggttg ctgctgtgtg actgggttgg 609421 cagccgcttt ctcgctcacc ttgcgttttc tgaacacaag gtaagaaatc agaacgattc 609481 ccgtgatgac gcctgtcagc agcagctcgt ctctcatgga atcaataaac gccatggaca 609541 ctaaaattcc gcaaatggcg atgatggtca agtaggttag gaaagggaag agccacattt 609601 tgatcttcaa tgcttctggg tttgtttttt cgagtttttt ccgcattttc agctgggaaa 609661 cggcgatgac aagatagacg agtaaagcga ttgcgcctga tgagttgact aagaataaaa 609721 agacggtatc cggtgaaaaa tagttcatta cgaccgcgat ataagagaaa aatgtcccgg 609781 ccacaatggc ttgtacggga acgccttttt tgctcaattt cataaaacgg cgcggcgctt 609841 catttctttc tgcaagtgaa tacagcattc tggatgtggt atacaaacct gaattcaggc 609901 aagagagtac ggctgtgagg acgataaagt tcataatctg tgcggctgcg ggcactccta 609961 tatgctcaag tacagcgacg aaagggcttt ctaaaatatt tgctgaattc catggcaaca 610021 gcgccacgac aatggcgatt gagcccacgt aaaagacgat gatgcgccat acaacggatc 610081 tggtggcttt tgtcacagat tcgatcgggt tggatgtttc ccctgctgca atggcaacga 610141 tttcagttcc cataaaagag aagatgacaa cgacaatgcc gagcaatacg gagctgatgc 610201 cctccgggaa aaatccgcct ttgcctgtaa gattcgaaaa accgactggc tcactgcccg 610261 gtgcaaagcc aaaaataaag gcaaaaccaa cgattagaaa agcaatgata gtcacaactt 610321 taatgaggga gaaccaatat tcaaactcac cgaaagactt aacggagtag acgtttgtca 610381 gggtgagcac aatggtcaag atcaaacttg tcagccacag cggaatatca tggaaccagt 610441 attgaataat gccagcaccg gcaatggctt cgatcgctat gacgatcacc cagaaaaacc 610501 agtacagcca gccgattgta aatcctgccc acggtccgat ggcgtcgtga gcgtattgag 610561 aaaacgatcc gctcgtcggg tttacggcag acatctcacc gagcattctc ataataaaaa 610621 tcaccaataa tccggctaac gcgtaagaaa caacggcacc cggaccggtc gagtgaatca 610681 ctgaaccgct gcctacaaat aggccggctc cgattacacc ggcaatcgaa atcattgtca 610741 tatggcgggt ctttaattcc ttttttaatc ctgattgaga ctggttcata agttacctcc 610801 ttttaaaatg caatcattac tgaatattat gataattgaa actctatcat aaatatacag 610861 tttgtcgaaa attcgtgtaa gaaaatatac cagcttattt caaatttgta gtgttttgtt 610921 tgcgctttca gcgaatgtgt ggaaaaaatg tttcgttttt tattcgctgt gtgattttgc 610981 gtaatattta caattcgata gaatgcgaga agcactggtg tccttgggtt tgatgggatt 611041 tttggcggag caaataaatt ggatgagaga aaaagtgttc cttcgtcact atttttctgt 611101 ggcgggtgaa tcatgtttct gtagacccac tgcggatcag ctttgtaaga taataatagg 611161 aaaatgtgag cgagaggagg ttttgtatgg agagatatga tgaactgaaa aagggagaat 611221 ccggagcgct ggtcagcatt gccgcgtatc tagttctttc cgcaattaaa ctgatcatcg 611281 gttatctttt tcactcggaa gcacttacgg cagacgggtt aaataacaca actgacatta 611341 ttgcttctgt tgctgtgctg attggcctgc gcatctctca aaagcctcct gacgaagatc 611401 atccatacgg ccactttcga gcggaaacga ttgcatcgct tatcgcatcg tttattatga 611461 tggttgtcgg actgcaagtg ctgttcagcg ccggagaatc tattttttct gctaaacaag 611521 agacgccaga tatgattgcg gcttggacgg cagcgggcgg ggcagtcctg atgctgatcg 611581 tttaccggta caataaaagg ctggccaaaa aggtgaagag ccaggcgctc cttgctgcgg 611641 ctgctgataa taaatcagac gcattcgtca gtatcggcac atttatcggc attgtggctg 611701 ctcaattcca tcttgcttgg attgatacgg tcactgcgtt tgtgatcggt ctgcttattt 611761 gcaagaccgc atgggatatc tttaaagagt catctcactc tttgacagat ggattcgaca 611821 taaaggacat ttccgcttat aaacagacaa tcgaaaaaat ctccggtgtg agccgtttaa 611881 aagacataaa agcaagatac ttgggcagta cggttcatgt tgatgtggtg gttgaggtat 611941 cggcagattt aaatattacg gaaagccacg atatagccaa tgaaattgag cggagaatga 612001 aggaggagca tgcgattgat tattcgcatg ttcatatgga gcctttagaa caaaaataat 612061 ggagcttcct gtcacaggaa gcttcagcgt gtcgacaaac cctcgcattc gttgtcaggt 612121 ctgcgcttcg gtgctcacga attagaacat tcgctccgct cctatgctcg tccttcctag 612181 acttcaaggg ttttcaatca cgctgaaaag atgacaaaac cctaaaatga aagccatttt 612241 aggattttgt caacaatctg gagcttcctg ccacaggaag cttttttgtg tgttttggcc 612301 agctttattg gtaacaattt gctagaatcg tttttttata cagattgctt tttgtggtaa 612361 agttaggtta cattatgatg aattttgtag atgactagga ggaaaataat ggcatatcaa 612421 gaagacctgc atcctttgct ggggaaagca gttgaacata ttaatagagt aatggttgga 612481 aaacgagaca tcgccatact cagcttagca gcccttcttg ccaaagggca tgtgctgctt 612541 gaggatgtac ccggagtcgg aaaaacgatg atggtccgcg cgctggcaaa gtcaatcggc 612601 gccgatttca aaagaatcca attcactccg gatttgctgc catctgatgt aacaggggta 612661 tctatctata atgcgaaaac gatggaattt gaatatcgtc ccggcccaat tatgggaaat 612721 atcgtgctgg cagatgaaat caaccgtacc tctccgaaga cacagtcggc tttgctcgaa 612781 gcgatggaag aggggagcgt cacggtagat ggccatacga tgcagcttgc cgatccgttt 612841 tttgtgatgg caacgcaaaa cccggtcgaa tatgaaggga cctatccttt gccggaagct 612901 cagcttgacc gttttttatt caaacttcgg atgggttatc cgtcctttaa tgaagagctt 612961 gacgtcttat ctcttcagga aaaaagccat ccgattgaga cgcttgagcc ggttattgca 613021 aaagaagact tcatcttttt acagagggaa gtgcaaaatg tccgtgctga tgacagcatt 613081 aaggaatata tcgttgaaat tgtgcagaaa acgagacagc atccttctgt tcaattaggc 613141 gtcagtccgc gcggctcaat cgccctcatg aaagcggcac aggcatacgc gctgctgcat 613201 catcgcgact atgtcatacc ggatgatatt caatatttag ctcctttcac gctgccgcac 613261 cggatgatgc ttcatcctga ggcaaaattt gaagggattc aggcagaagc gatcgtaagg 613321 gagatcatgt cagctgtgaa ggtgccggtt caaaggtcgg cggtccgctg atgaataaga 613381 aatggcaatg gctcgtatat ggttggaagc tgattatatt aactttattg acggctgctg 613441 ttttttctta tgcgatgttt cagggcggct ttgtcagctg gtttttgttt tacgcgtttc 613501 tcccttttgt cttgtatgcc gggctgttgg ccttgtatcc gctccgttct tttcaggctt 613561 caaggcaaat ggataaaaca caattgcatg cgggggacag gctgggcgta acggttacgc 613621 tgagaagaaa gctgccattt ccgctgatgt atatggtgat tgaagattgc ctgccagaag 613681 gtatcgagtc attaaatcga gacggagccg cggccaaacg gctcgttttt ccttggttta 613741 aacggagcat gacgatgtcg tatgaattag ctcgggtacc gcgcggagag catcactttc 613801 attctgtcag ggtgcgaacc ggggatgttc ttggcttgat tgaaaaaaca gcattttttg 613861 agctggatga taccttgttt gtttatccat tctatcagcg tttttcctat caggtgaatg 613921 agaggcatca ggaagacggt gtaagcggtt cttctcctat tcatcagcac cattcctcag 613981 tcgcagcaag tgtgcggaat tatcagccgg gagaccggtt tgctgcgtta gattggaaga 614041 catctgcacg gcggagccag ctgatgacga aggaatttga gccttctcgc agcaaaaatc 614101 tgtttctgct gatggaccgt ttttcctcag acgcattcga agaggtcgtt tcagtgacag 614161 cttcgattct tcattctgtt ttaaaaaacg gcgcgggtgc tggtctggct tccatcggga 614221 aggaaaaaaa cattttccct attcaggaag gggatcagca ttttaagcac atgcttcggc 614281 atttagccat cgctcattgt gatgcggcag acccgataag ccgatatgca cgggaagagc 614341 tgggaaagcc atctgttcgc caagctgatc aagttgttgt cacgggacag ttaacggaag 614401 atatgctgca cctcgcagaa ataggaggcg gccgggttac ggtgatactg gcaaaagaga 614461 aagatgctga gctctctcaa gctgaaaatg tcatgattga acgcatgatg aaacgccaaa 614521 tcagagttcg gatcatgagg ggcgggcgag tttcgcgtgt tgtttagaaa gagaggtgac 614581 tggttcacat gccgcacgat gatcacaagg gaagccgttt gagcttgctg ttattttatt 614641 ttctggcttt tttattgctg tgggagtggc ttaggccgct tgacagtttt actgaaacga 614701 aacatacagg cttttttagt gtctttatcg gcttgacgtt tctgctgact tttttcagga 614761 tgaggtggtt tgtcaccgtt cctttttgtg tcatatttac attgatctcg atacacatcc 614821 tgttttatca aggatctata ttcgacttga gctgggtcag ctcttttttg caggatgtct 614881 atctgaatat cacgctgatt caatcagggc aatggaatga catgattcct tcatttcgga 614941 ccctgctgtt ttttgtgctg ctgtggctgc tggtctatct cctgcattat tgggtgattt 615001 accagagaag aattttgttt ttctttttga tgacagtagc gtatattacg attcttgata 615061 cctttacgcc atatgatgcc acttttgccg taatccgtat cgtgctgatc ggcttcttta 615121 tgctgggcct tttatacttg gaacgcatta agctgatgga aagaatcaca ctgccaaaaa 615181 catctgtcct gaaatggttt cttcctttat ctgtattggt tttggctgca acgggattcg 615241 gactcgccgc tccaaaatca gagccggctt ggcctgatcc ggtgcctttt cttaaaaaaa 615301 tcactcatca agaccgcgtg tctgcagggg aaagcaaaat cggatacggg aatcatgatg 615361 aatcactcgg cggcccgttc cagcaggatg ctacacctgt ttttacatgg cagggaaaag 615421 agcgtacgta tttccgtgtg gaaacgaagg acacgtatac cggaaaaggc tggattgaaa 615481 cagacacagg catgtcgtat cagcttagca atggaaaagt tgaaaatctg tggtttgacc 615541 ataaggttgc gacagagcgc cgcaccgtcc gtgtaaaagt cgataagcac tacgggtata 615601 accatctgat gtatccgatt ggtgcggaaa ccattcagcc aaagcaggct gtctcacttg 615661 aaatgaacgg caacacggag caaatttctc cgatcagtga acaagccggt gaaatcagaa 615721 atatggggaa ttatacagta acgtacaatt ccccggtcta taagctggat gaactgagaa 615781 aggtaaaagt gagaaaaaac agtgaggagt acacattcag cgatcgctac atgcagcttc 615841 cagattcact gccagagcgg gtgagaaccc ttgcgatcaa actgactcag gatcacgaca 615901 atatgtttga taaggtgaaa gcggttgagg actatttagg gtcaaatgcg ttcacatatg 615961 aaacagaaaa cgtgaccatt ccgaagaatg atgaagatta tgtcgatcaa tttctctttg 616021 aaacgaaaat gggttattgt gataactttt cttccgccat ggtggtgctc ttgcgctcgg 616081 ccggcattcc ggcccgctgg gtaaagggtt atacgtccgg cgaatacaaa gaagcaggga 616141 acaaaaatgg cagcatttac gaagtgacaa ataacaatgc ccattcctgg gtagaggtgt 616201 atttcccgga acagggctgg gttacatttg agccgactaa agggtttaca aatccggctc 616261 aatttacatc ttctgacaca aaagactctg gcagcgatag cagcagctcg ccgaagaaag 616321 caaaagagaa acagaaagaa gagaaaaaac agccgcaaaa agaggaaaaa caaaaggaaa 616381 agcgggagcc agctgtttct aaaaagccgt ccgcttcgca tactaatgcc ggtgcgggct 616441 tgtatgcagc gcttgcggtt cttgcagtcc tcctggtggc agctgtattg ctgtatgttt 616501 tccgctcgtt atggattcct gttttcgccg tgaggaaatt gaagcggcgc agtgatcagc 616561 acgcgttttt tgaggcatat ggcgcgctgc tgaaacaact gaagagaaaa ggactgccga 616621 aacgagacag tgaaacgctg cgtgattatg caaaacgaat tgatgaaaaa tacgacatag 616681 aagacatgtc aaagctgaca ttaagctatg aaagggcgct ttacagaaat gaagattctt 616741 cggcgctatg gaatgattcg agagagttat gggaaaattt aattaaaaga agatggtctt 616801 gaccgcttat cgacgtgttg ttagaattag tgaatattat cggagtctgg gagcgagttg 616861 gcctgactcc ggcaaacggc cttgccaaag agggcggagc gagcttcata tctgtcctcg 616921 tttttttctg tgtcaaaaaa cttagaggag attaggtgac aaccatgaca aagttagtga 616981 atgaaatgat tcttgtcctt gatttcggca gtcagtataa ccagctgatt acacgccgta 617041 tccgtgaatt cggtgtttac agcgagctgc atccacatac attgacggct gaagaaatta 617101 aaaaaatgaa tccaaaagga attattttat ccggcggtcc aaacagtgtg tatgatgaaa 617161 actctttccg ctgtgacgag aaaatcttcg agcttgatat tcctgttttg ggaatttgct 617221 acggcatgca gctgatgact cattaccttg gcggtaaagt tgaagcggca agccagcgtg 617281 aatacggaaa agcaaacatc cgcatcgaag gcacacctga tttgttcaga gatcttccga 617341 atgaacaagt ggtttggatg agccacggcg atttggttgt agaagttcct gaaggcttca 617401 ctgttgacgc gacaagccat cactgcccga actcagcaat gagcaaagcg gacaaaaaat 617461 ggtatggcgt tcagttccac ccggaagtgc gccactctga atacggcaat gatcttctga 617521 aaaactttgt attcggtgtt tgcgaatgcg aaggcgaatg gtcaatggag aactttatcg 617581 aaatcgaaat gcaaaaaatc cgtgaaacgg tcggagacaa acaggttctt tgcgcgctaa 617641 gcggcggcgt tgattcctct gttgttgctg ttttgattca taaagcgatc ggcgaccagc 617701 tgacttgtat ctttgtagac catggtcttc tccgtaaagg cgaagctgag ggtgttatga 617761 aaacattcag cgaaggcttt aacatgaatg tgattaaagt agacgcaaaa gatcgattct 617821 taaacaaact aaaaggcgtt tctgatcctg agcaaaaacg caaaatcatc ggtaatgaat 617881 tcatttacgt gtttgatgat gaagcggaca agctcaaagg catcgactac cttgcacaag 617941 gtacgcttta cacagatatc atcgagagcg gtacagcaac ggcgcaaacg atcaaatctc 618001 accacaatgt cggcggactt cctgaagaca tgcagtttga gctgatcgag ccgttaaata 618061 cgctcttcaa agacgaagtg cgcgcgcttg gcacagagct cggcattccg gatgaaatcg 618121 tatggcgtca gccgttccca ggaccgggac tcggaatccg cgttcttggc gaagtaacag 618181 aagaaaaact tgaaatcgtt cgtgaatcag atgcaatctt gcgtgaagaa attgcaaatc 618241 acggcttaga gcgtgatatc tggcaatact tcactgttct tcctgacatc cgcagcgttg 618301 gtgttatggg tgacgcaaga acatatgatt acacaatcgg aatccgcgcc gttacatcaa 618361 tcgacggcat gacatctgac tgggcgcgta tcccgtggga tgtgcttgaa gtcatttcga 618421 cacgtatcgt aaacgaagtg aagcacatta accgcgtggt gtatgatatt acaagtaagc 618481 cgcctgcgac gattgagtgg gaataagaat caattaatgg aaaccatctt tttggcaatt 618541 ttgccgggaa gatggtttta tttgtttatt acgaacaaaa tccgattttg cgcgactatt 618601 gttcgctttt tgtattgttt tttcaaaatg aacttggtac aatagacaca gaaatcaaat 618661 aagatgaatt cgtataatcg cgggaatatg gctcgcaagt ctctaccaag ctaccgtaaa 618721 tggcttgact acgtaaacat ttctttcgtt tgatataaat aaaacacggt tatttattca 618781 aactgaaatc cgtctgtagt caagcgtccc aaaatgtatt gggacgtttt ttatttggcg 618841 ttttcaggac agaataaata gcaaagagtg aagggagtca aatagcttga aaacgttttt 618901 tcagtttgat gagctgggca ccagctatcg caatgaaatc attggcggat taacgacttt 618961 tttatctatg gcatatattt tgttcgtcaa tccgattacg cttgctttgg agagcgtgaa 619021 agattttccg gaggcgctga gaattgacca gggtgcggtc tttacggcga cagcgctggc 619081 gtctgcagca ggctgtatct taatgggatt aatagcgaga tatccgattg ccatcgcgcc 619141 gggtatgggg ctgaacgcgt tttttgcgtt ttctgttgtc cttggtatgg gtatttcatg 619201 gcaggcagct ttgtccggtg tttttatttc aggtcttatt ttcgttgctc tttctttaac 619261 aggttttcgt gaaaaaatca tcaacgccat tccgcctgag ctgaaattgg cagtcggtgc 619321 ggggatcggc ctgtttatta catttgttgg attacaaggt tcaggaatca ttacagcgaa 619381 tccttctacg ctcgtcacga tcggaaacat tcacagcggt cctgtgctgt taacgatttt 619441 cggtgtgatt gtcacggtta ttttaatggt gcttcgcgtg aacgcaggcg tgtttatcgg 619501 gatgctatta acagcggtag ccggcatgat tttcggtttg gttccggttc cgactcaaat 619561 tatcggcagt gtgccaagcc ttgcgccgac tttcggacaa gcgtggattc acctcccgga 619621 tattttctct gtacaaatgc tgatcgttat tttaacattc ttgtttgtcg gattttttga 619681 tacagctggt acacttgttg ctgtggcaac acaagctggt ttaatgaagg aaaacaaatt 619741 gccgcgtgcg ggccgtgcgc ttttagctga ttcatcttct attgtgatcg gtgccgtgct 619801 tggtacgtct acaacaactt cttacgtgga atcaagctca ggtgtcgctg cgggtgcccg 619861 gtcaggattt gccgcaattg taacagggat tctcttttta ctggctacgt ttttctcgcc 619921 gctcctatca gtcgttacgt caaatgtaac agcgccggcg cttattattg ttggtgcatt 619981 gatggtggcg ccgcttggca aaatcgcttg ggataagttc gaagtggccg ttcctgcttt 620041 ccttaccatg atcatgatgc cgttaacgta cagcatcgcg actggtattg ccatcggatt 620101 tattttctat ccgattacaa tggtgtgcaa aggaaaagca aaagaggttc atccaatcat 620161 gtacgggctg tttgtcgtat ttatcctgta ctttatcttc ttaaaataag gaatgaaaaa 620221 ccagctgcac tggcagctgg tttttttgtt gcaaaagata aaaccatttc atacgatata 620281 ccgtcatgta gatgtgccgc catgctttac ttaaatggaa atgacttgac tgttcaggaa 620341 ggcttcggta ccttatataa gtgttttatt ttcttgctga atggtattcc gccgtatttt 620401 tttgatagga gttgctgaca tgacggaaga aagaaaagaa acgtttgaag aagaaattaa 620461 ccagagtgaa agaatagatg cagatgaaga accgctatcg agaatgtcca gaaaggcgag 620521 ccggcaaagc aagcagaagc aaaaacaaaa gcagaaaccg cgccaggaac gcggtgaatc 620581 aactgttaaa gacaagcttg cgtctgtttg ggcagccatc aacagatatt gcggttttgc 620641 gttctcgatt ttaaaatctc cggcgaaaac tgtcgtaacg gatggttttt ctcattataa 620701 gtacggtctg atttcaatgc ttatattcag tatcattttt tcaattggga attggtttca 620761 gttaaaggca agctggaatc ggccgctcgg tttcggagaa cgccatcatg ctttctatga 620821 cgggttttta gttgttcttg tgtatttgct gatctttttc gcggtaatgg tctttgctat 620881 atgggctgtc tcccgctata tgatgaagca gaaggtgacg ttcagagaag cggctgccgt 620941 attgggttca ttgcttgtac ccgtaattgc tgtttcaatc ctttggctga tctttgcgat 621001 cgtaaatatc ccaatgctga cagtactgtt tacggtgctg atcttgtttt ccatcttttt 621061 tatcatcgcg ctgtatgtac agcgtgtgta ccaggcggca caagatgcac caattgatta 621121 tatctattgt gtatttgcag tagttgcgat agcgctgctg tttacggcag tgacttggcc 621181 gtttatttct gaatatatta cggcgtcgtt gattccgctt taatgaaaaa accggctaat 621241 cctagccggt ttttttatgt cacacttttt acaaatatat ctaaaaaaca tagttgattt 621301 gtaggattaa cccgtgtatg atggggaaaa tgctgaaaac gtccagcgca aaaaccttta 621361 tgtttaagga ggatgatgga catggctgat gtacttcgcc gagcaattaa ccaaaagaag 621421 caatttttaa aaaccaaatt actgctctcg gaattttatc aaggaagagg ggaacagctt 621481 gctgactaca cgctgagtga gcttgagaaa gaatacaagt cccttcagaa aatgaaaaaa 621541 gagatctgac aatagatata aagaggtgag tctgctgaaa agcgggcttt tttgttttga 621601 ttttgaaaag gcgagaaaga gggtaaacta ctactgttca acacataaaa gcgtgtcgaa 621661 atattttgct taagcttacg ggcgaagctg attgtaaacg gctcatttct ctagtagaat 621721 atgaatgctt tgtgcaagct gaagagtagg gggatgaata aaatgatgca aaccatctta 621781 tcaaatggga tagccatggt tctcataatt ctcattatta atattgtcta tgtgtcattt 621841 tttacgataa gaatgatttt aacgctgaaa ggacagcgtt atttagcggc cggcatcagt 621901 acgattgaaa tactggttta tgtgacagga ctgagtctgg tgctcgataa cttagaccag 621961 attcaaaatg tgatcgcgta cgcgctcggt tacggtcttg gcgtaattgt cggcatgaaa 622021 atagaagaaa aattggcgct tggctatatt atggtcaatg tgattacgaa ggagctcgat 622081 cttgatcttc cgaagcagct ccgtgaaaaa ggctacggcg tgacaaactg ggtggcaggc 622141 gggcttgaag gcgaccgcac agcccttcag atcctgacgc cgagaagata tgaactccag 622201 ctatatgata cgattaaaac acttgattca aaagccttta ttattgcgta cgaaccaaaa 622261 acaatccacg gcggcttctg ggtcaaagcg gtgaagaaga ggagaattaa agaataatgg 622321 caaagccgaa gaagaaaaag tttgaagtga cagagcagca aacgattgat gcggtgcttc 622381 agcaaatgaa agaagaagga tatctgcctg taaggcgaat ggaagagcct atttttatgg 622441 aaaaaaagga aaatgggtca attcagatcg ttccgtgcgg gaaaaaaatc gtatttgaag 622501 ggaaattgat ctaaaacacg aacattagta gaatgaattt ttgtatcgtt cgataatatc 622561 gttgacatta tccatgtccg ttgttaagat aaacatgaaa tcaaaacacg acctcatata 622621 atcttgggaa tatggcccat aagtttctac ccggcaaccg taaattgccg gactatgcag 622681 gaaagtgatc gataaaactg acatggatat atcgcagaag cgaacgactg acgatacatg 622741 taccatgccc ggtttgtatt gcttcctcat aagtgcaatg cagagcgggt attttttatt 622801 ttctgaaaac aaaagcatta gaaggtgggg aacagaatgc agccgctagt aggaatcatc 622861 atgggaagca cttccgattg ggagacaatg aaacacgcat gcgacatact tgacgaactc 622921 aatgttccgt acgaaaaaaa ggtcgtttcc gctcaccgga cgcctgattt catgtttgaa 622981 tatgctgaaa ctgctagaga aagaggcatc aaggtgatta ttgccggtgc cggaggagcg 623041 gcgcatctgc cagggatgac ggctgcgaaa acaacactgc cagtcattgg agttccggtt 623101 cagtccaagg cgctgaacgg aatggattca cttctttcca tcgtccaaat gcctggaggc 623161 gtgcctgttg cgacaacatc catcggcaaa gcgggtgctg tgaacgcagg cctgttagcg 623221 gcgcaaattt tgtcagcatt tgacgaagac cttgcccgta agctggatga gagaagagaa 623281 aatacaaaac agacagtgtt agaaagcagt gatcagcttg tctaaacaaa tcatctatcc 623341 gggagctgta atcggcatta tcggcggcgg ccagcttggg aaaatgatgg ctgtgtccgc 623401 caaacaaatg gggtataaag tcgcggtcgt tgatccggtg aaagattcgc cgtgcgggca 623461 ggttgcggat gtcgaaatta ccgctcatta taatgaccgt gaagcgattc gaaaattggc 623521 tgaaatcagc gatatcatca catatgagtt tgaaaacatc gactatgatg cgctgcattg 623581 gctaaaagat catgcgtatc tcccgcaagg aagtgagctg ctgcttatta cccaaaaccg 623641 tgaaacagag aaaaaagcaa ttcaatccgc gggctgtgaa gtcgcaccgt acagcatcgt 623701 caaaacaaag aatgaattga aacaggcagt acaggagctc aggcttccgg cagtgctgaa 623761 aacatgccgc ggcgggtacg acggcaaagg ccaatttgtg ataaaagaag aggcgcaaat 623821 ggagcaggca gccgctctgt tagaacacgg aacttgcatt cttgaaagct gggtttcttt 623881 taaaatggaa ctgtcggtga tcgtcgttag atcggtaaac ggtgaaattt caacatttcc 623941 gacagctgaa aacattcacc acaacaatat tcttttccaa agcatcgtgc ccgcacgggt 624001 agagaaaggg attcagcaga aggctgctga tctcgcagtt aagcttgcag atgagcttaa 624061 ccttgtcgga ccgcttgctg ttgagatgtt cctgacagag gacggagagc ttttggtcaa 624121 tgaactggcg ccaagaccgc acaattcagg gcattatacg ctggaccttt gcgagacgag 624181 ccagtttgag cagcatatca gagcggtatg cgggcttccg cttgggaaga cagatttgct 624241 gaagccgggc atgatggtga atcttctcgg cgatgaagtg aagcttgttg aggaagaccc 624301 ggagctttta aaagaggcaa agctatatat atacggaaaa catgaaatca aaaaaggccg 624361 caaaatgggg catattacat ttatgaagca gcctgaagac gaatggattc aggagatcac 624421 aaataaatgg atgaatagag acggaggaca agcagaatga tcgaacgtta ttcaagacct 624481 gaaatgtccg cgatttggac ggatgaaaac agatttcaag catggttaga ggttgaaatt 624541 cttgcctgtg aagcgtgggc ggagcttggc gtcattccga aagaagatgt aaaggttatg 624601 cgcgaaaacg cgtcatttga catcaaccgc attttagaaa tcgaaaagga cacgcgccat 624661 gacgttgtcg cttttacgcg cgctgtatcc gaatcactgg gcgaagaaag aaaatgggtg 624721 cattacggct taacgtcaac tgacgttgtt gatacggctc tttcctactt attaaaacag 624781 gcaaacgata ttttgctcaa ggatcttgag agatttgttg acattataaa agaaaaagcg 624841 aaagaacata aatacacagt catgatgggg cgcacacacg gcgtacacgc tgagcctaca 624901 acattcggct taaaacttgc gctttggcat gaagaaatga aacgtaatct tgagcgcttc 624961 aaacaagcga aagcaggcat cgaggttgga aagatttccg gtgctgtcgg cacatatgcg 625021 aacattgatc catttgttga acaatatgtc tgtgagaagc tcggattgaa agcagcaccg 625081 atttccactc aaacccttca gcgtgaccgc catgctgact atatggcaac acttgctttg 625141 atcgcgacaa gcatcgagaa attcgctgtg gaaatccgcg gactgcaaaa gagtgaaaca 625201 cgtgaagtag aggaattttt cgcgaaaggg caaaagggtt catctgcaat gccgcataaa 625261 cgaaatccga ttggctctga aaacatgaca ggcatggcgc gcgtgatccg cggctacatg 625321 atgacagctt acgaaaatgt tccattatgg catgagcgcg atatttctca ttcttcagca 625381 gaacgaatta ttcttccgga tgcgacaatt gcgctgaact acatgctgaa ccgcttctcc 625441 aacatcgtga agaacttaac ggtcttcccg gaaaacatga agcgcaacat ggaccgcact 625501 ctcggcctta tctattctca gcgtgtgctc cttgctttga ttgacacagg cctgactcgt 625561 gaagaagcct atgatacagt tcagccgaaa gcaatggaag cgtgggaaaa acaagtgccg 625621 ttccgcgagc ttgtggaagc ggaagagaaa atcacgtcac gtctttctcc agaaaaaatt 625681 gctgactgct ttgattacaa ttaccatctg aaaaatgttg atctgatctt tgaacgttta 625741 ggtttagcat agaagaagct tttagcggct tcttctaagc cgccgcagtt tgaaaattcc 625801 caacattcgg gttaggaggc cttccgtgaa tattgtgaag aatgaacttt tatacgaagg 625861 aaaagcaaaa aagatctaca aaaccgatga cgaaaacacg ctgtatgtcg tgtataaaga 625921 ctccgccact gcctttaacg gcgagaaaaa agcagaaatc agcggaaaag ggcgcttaaa 625981 taatgaaatt tcaagcctca ttttcaaaca ccttcatgct aagggcatta acaatcattt 626041 tatcgagcgc atttcggaaa cggagcagct cattaaaaag gtaacgattg tgccgcttga 626101 agtcgtggta agaaatgttg tggcaggaag catgtccaaa cgtctcggca ttccagaagg 626161 cacggagctt gagcagccga ttatcgagtt ttactacaag gatgacgcgc tgggtgatcc 626221 gctcatcaca gaagatcata tttggctttt gaaggcggcg actcctgagc aggtagaaac 626281 cattaagtcc attacaacaa tagtaaatga agagcttcaa agcatcttcg acgattgtca 626341 tgtcagatta atagatttca agcttgaatt cggtttagat gcagaagggc aagtgctttt 626401 ggcggatgaa atatctcctg acacatgccg cttgtgggat aaagaaacga acgaaaagct 626461 ggacaaagat ttattcagac gcaatctggg aagcttaacc gacgcatacg aagagatttt 626521 caatagactg ggaggcattc atcatgtata aagtaaaagt ttatgtcagc ttaaaagaaa 626581 gtgtactaga tccacaaggg agcgctgtcc agcatgcctt gcacagtatg acttacaacg 626641 aagttcaaga tgtgcgcatc gggaaataca tggagcttac cattgaaaaa tctgaccgtg 626701 atcttgacgt gctagtgaaa gaaatgtgcg aaaaacttct tgcgaacaca gtgattgaag 626761 attatagata tgaggttgag gaggtagtcg cacagtgaaa tttgcggtga ttgtgttacc 626821 cggctccaac tgtgatatcg atatgtatca tgctgtaaag gatgagctcg gccatgaagt 626881 ggaatacgtc tggcatgagg aaacaagcct tgacggcttc gacggcgtgt taattccggg 626941 aggattttct tacggcgatt acttaagatg cggcgccatc gcccgatttg cgaatattat 627001 gccagctgtc aaacaagcag cggctgaagg aaaacctgtt cttggcgtct gtaacggatt 627061 ccagatttta caggagcttg ggctgctgcc aggcgcaatg agacgcaaca aagatctgaa 627121 gttcatttgc cgtccggttg aattgattgt tcagaacgac gaaaccttat tcacagcttc 627181 ctacgaaaag ggagaatcga ttacaatccc ggttgcccat ggtgaaggga atttctactg 627241 tgatgacgag acgcttgcta cattaaagga aaacaatcaa attgctttca catacggctc 627301 taatattaat ggaagtgtca gcgacattgc cggtgtcgtg aatgagaaag gcaatgtatt 627361 aggcatgatg cctcaccctg agcgcgcggt cgatgaactg cttggaagcg ccgacggtct 627421 taaattgttc cagtctatcg tgaaaaattg gagggaaact catgtcacta ctgcttgaac 627481 caagtaaaga acaaataaaa gaagagaaac tgtatcagca aatgggtgtc agtgatgatg 627541 agtttgcatt gatagaatcc attcttggaa gattgccgaa ctacacagaa atcggaattt 627601 tttctgtcat gtggtctgag cattgcagct ataaaaactc aaagccgatt ctgcgtaaat 627661 tcccgacaag cggcgagcgt gtgctgcagg ggccggggga aggcgccgga atcgttgata 627721 tcggtgataa ccaagcggtt gtgttcaaaa ttgaatcaca taaccaccca tcagctctcg 627781 agccttacca aggcgctgcg actggcgtag gcggaattat ccgtgatgta ttctcaatgg 627841 gtgcacgccc aatcgctgta ttgaactctc ttcgatttgg tgaactgact tcaccccgcg 627901 tgaagtactt gtttgaagaa gtagtagcgg gtatcgccgg atacggcaac tgtatcggca 627961 tcccgacagt cggcggagaa gtgcagtttg acagcagcta tgaaggaaat ccgctcgtca 628021 acgcaatgtg cgtcggttta atcaaccatg aagacatcaa aaaaggccag gcaaagggtg 628081 tcggcaacac agtaatgtac gtaggagcga aaacagggcg tgacggcatc cacggcgcta 628141 cgtttgcttc tgaagaaatg tcagactcgt ctgaagaaaa gcgttctgct gtccaagtcg 628201 gcgatccgtt tatggagaag cttttgcttg aagcatgtct ggaagtcatc caatgcgacg 628261 ccttagtcgg cattcaggat atgggagctg ccggtttaac aagctcaagt gcagaaatgg 628321 caagtaaagc cggttctggc attgaaatga atcttgacct gattcctcag cgcgaaacag 628381 gcatgaccgc gtatgaaatg atgctttctg aatcacaaga acggatgctt ttggttattg 628441 agcgcggacg tgagcaggaa atcatcgata tttttgacaa gtatgatctt gaagcggttt 628501 ctgtcggaca tgtgacagat gataaaatgc ttcgcctgac acataaagga gaggttgtgt 628561 gcgagctgcc tgttgatgcc ttggcagaag aagcaccggt ttaccataag ccttctcaag 628621 agcctgctta ctatcgcgag tttttggaaa cagacgttcc ggctccgcaa attgaagatg 628681 cgaatgaaat gctgaaggcc cttcttcagc agccgacgat tgcgagtaaa gagtgggttt 628741 atgatcagta tgactacatg gtgcgcacga atacagttgt cgctcctggg tctgatgctg 628801 gtgttctcag aatccgcgga acgaaaaagg cgctggcgat gacgacagac tgtaacgcgc 628861 gttatctcta tcttgatcct gaagtcggag ggaaaattgc tgtcgctgaa gcagcgcgca 628921 acatcatttg ctcaggcgca gaaccgcttg cggtgacaga taaccttaac ttcggaaacc 628981 ctgagaagcc ggaaatcttc tggcagatcg aaaaagcggc agacggcata agcgaagcgt 629041 gcaatgttct cagcactccg gttatcggcg gtaacgtatc gctttataac gaatcaaacg 629101 gcacggcgat ctatccgaca ccagttatcg gcatggtcgg cctaattgaa gatacagcgc 629161 acattacaac acagcatttc aaacaagcag gagatctcgt atacgtgatc ggcgaaacaa 629221 aaccagagtt tgccggaagc gagctgcaaa aaatgacaga aggccgtatt tacggcaaag 629281 cgccgcaaat cgatcttgat gtagagctgt ctcgtcaaaa agcactgctt gacgcgatta 629341 aaaaaggctt cgttcaatct gcgcatgatg tgtctgaagg cggcttaggc gtagcgattg 629401 cggaaagtgt catgacgacg gaaaaccttg gcgctaatgt gactgtagaa ggggaagcgg 629461 cgttattatt ctctgaatct caatctcgct tcgtcgtttc agtgaaaaaa gaacatcaag 629521 ctgcgtttga agcaactgtc aaagatgcag ttcatattgg tgaggtaaca gctgacggaa 629581 ttctggcgat tcaaaaccaa gacggacaac aaatgattca tgcgcaaacg aaagagcttg 629641 aacgcgtatg gaaaggagct atcccatgct tgctgaaatc aaaggcttaa atgaagaatg 629701 cggcgttttt gggatttggg gacatgaaga agccccgcaa atcacgtatt acggtctcca 629761 cagccttcag caccgaggac aggagggtgc tggcatcgta gcgactgacg gtgaaaagct 629821 gacggctcac aaaggccaag gtctgatcac tgaagtattt caaaacggcg aactcagcaa 629881 agtaaaggga aaaggcgcta tcgggcacgt tcggtacgca acggctggag gcggcggata 629941 cgaaaatgtt cagccgctcc tcttccgttc ccaaaacaac ggcagcctgg cgcttgctca 630001 taacggaaat cttgtcaacg ccactcagct gaagcagcag ctcgaaaatc aagggagcat 630061 ctttcaaacc tcttcggata cagaggtttt ggctcacctg atcaaaagaa gcggacactt 630121 cacgctgaag gatcaaatta aaaactcgct ttctatgctg aaaggcgcct acgcgttcct 630181 gatcatgacc gaaacagaaa tgattgtcgc acttgatcca aacgggctga gaccgctatc 630241 catcggcatg atgggcgacg cttatgtggt cgcatcagaa acatgcgcat ttgacgtcgt 630301 cggcgcaacg taccttcgcg aggtagagcc gggagaaatg ctgatcatta atgatgaagg 630361 catgaaatca gagcgttttt ccatgaatat caatcgttcc atttgcagca tggagtacat 630421 ttatttctcc agaccagaca gcaatattga cggtattaat gtgcacagtg cccgtaaaaa 630481 ccttgggaaa atgctggctc aggaatccgc agttgaagct gacgtcgtaa ccggggttcc 630541 ggattccagt atttcagcgg cgatcggcta tgcagaggca acaggcattc cgtatgagct 630601 tggcttaatc aaaaaccgtt atgttggcag aacgtttatt cagccgtccc aggctctgcg 630661 tgagcaaggc gtcagaatga agctgtctgc ggtgcgcggg gttgtagaag gcaaacgcgt 630721 cgtgatggtg gatgactcta tcgtgcgagg aacaactagc cgccggattg tcacgatgct 630781 aagagaagcg ggtgcgacag aggtgcatgt gaaaatcagt tcaccgccga tcgctcatcc 630841 gtgcttttac ggcattgaca cttccacaca tgaagaactg atcgcgtctt cgcattctgt 630901 tgaagaaatc cgtcaggaaa tcggagccga taccctctca tttttgagtg tggaagggct 630961 gctgaaaggc atcggcagaa aatacgatga ctcgaattgc ggacagtgtc tcgcttgctt 631021 tacaggaaaa tatccgactg aaatttacca ggatacagtg cttcctcacg taaaagaagc 631081 agtattaacc aaataaaact tgaaaaatga cataaaggca gcgcagttcg gctgcctttc 631141 tctttctgcc ctcgttcggg gagatatttt gaaaagcgcc ttaaaggagt gaataggatg 631201 tctgaagcat ataaaaacgc aggagttgac atcgaagccg gatatgaagc tgtaaaacga 631261 atgaaaaaac acgtggagcg cacgaaacgg cttggcgtta tgggcagcct tggcggtttt 631321 ggcggcatgt ttgacctgtc tgagctttct tatcaaaaac cagttctcat ttcgggaacg 631381 gacggtgtcg gcacaaaatt aaagctcgct ttttccatgg ataagcatga cacgattggc 631441 gtggatgctg ttgcaatgtg tgtcaatgac gtgctggcac aaggtgcaga gccgctgttt 631501 ttcctcgatt atttagcggt tggcaaagcg gacccagtga aaattgaaca gattgtacaa 631561 ggtgttgcgg aaggctgtga gcagtcaggt tcagccttag tcggcggtga aacggctgaa 631621 atgccggggc tctatacagc tgatgaatac gatattgccg gtttctcagt cggagtggca 631681 gaaaaggacg aaatcgtgac tggagaaaaa attgaagagg gccatctgtt gatcggcctc 631741 agctccagcg gccttcacag caacggcttt tcccttgtca gaaaagtgct tctggatgat 631801 gcggagctgg acctcgatac aacatatgag ccgtttgaac gcccgcttgg cgaggaattg 631861 cttgaaccga caaggattta cgtgaagcct gtgcttgccg cggtcaaaag cggaaaaatc 631921 gacggcatgg cgcacgtgac aggcggagga tttattgaaa atattccgcg tatgcttccg 631981 gaaggcttaa gtgcggaaat tgatcatggc tcatggccga tcccgccgat tttttctttc 632041 ttgcaagagt acggcaagct aaaggaagaa gacatgttca acgtctttaa tatgggtatc 632101 ggttttgttt tggcagtcaa agaagagcat ctgacagatg tgatcggaac gcttgaaagc 632161 catggcgaaa aagcctattt aatcgggcgt gtgaaaaaag gtgaaggcgt cacattcggc 632221 ggtgcggcac tttcatgaaa aagtttgcgg tatttgcatc aggaaacggt tcaaacttcg 632281 aagccatcgt cacgcgtttg aaggaggaga actgggatgc gtcagcagcg ctcctcgttt 632341 gcgacaaacc gcaggcgaaa gtcatcgaac gggcggaagc attccacatt ccatccttcg 632401 catttgagcc gaagtcttat gaaaacaagg ctgcatttga acaagccatc attgaacagc 632461 ttcgtcttca cgaggttgaa ttgattgctc ttgccggcta tatgaggctg atcggtgata 632521 cgctccttca agcatatggg ggaaaaatca ttaacattca cccatcgctt cttccggcgt 632581 ttcctggaat cgacgcagtc ggacaggcgt tccgggcggg tgtgaaggtg gccggaatca 632641 ccgtgcatta tgtcgatgaa ggaatggata caggtccgat catcgctcaa aaggcaatcg 632701 aaattgatga acatgataca ttggaaacaa tcgaacagcg aattcacaag cttgagcata 632761 aatggtatcc gagtgtgatt aaacagctat taggattaaa taacagaggt gaaaaggcat 632821 gaccattaaa cgtgcattaa tcagtgtttc agataaaaca aatctcgttc ctttcgtaaa 632881 agaactgaca gagcttggcg ttgaagtcat ctccacaggc ggaacgaaaa agcttcttca 632941 agaaaacggt gtggatgtga tcggaatttc tgaagtgaca ggctttcctg aaattatgga 633001 cggccggtta aaaaccctac acccgaatat tcacggcggc cttctggcgg ttcgcggcaa 633061 tgaagagcat atggcgcaga tcaatgaaca cgggattcag ccgattgacc tcgttgtcgt 633121 caacctctat ccatttaaag aaacgatttc taaagaagac gtcacgtatg aagaagcgat 633181 cgaaaatatc gacatcggcg gacctggcat gctgcgcgcg gcatcaaaga accatcagga 633241 tgtcacggtt atcgtcgatc cggccgatta cagcccagtg ctaaatcaaa tcaaagaaga 633301 aggcagcgta tctcttcaga aaaaacgcga gctcgcggca aaagtattcc gtcatactgc 633361 ggcatatgat gcactgatcg ctgactatct gacaaatgtt gtcggtgaaa aagaaccaga 633421 gcaattcact gtgacatttg agaaaaaaca atcgcttcgc tatggagaaa acccgcatca 633481 ggaagcaact ttctatcaaa cagctcttcc tgtcaaaggc tccattgcgc aagcagaaca 633541 gcttcacgga aaagagcttt cttacaacaa cattaaagac gcggatgctg cagttcaaat 633601 cgttcgtgaa ttcactgaac cggctgctgt tgctgtgaag catatgaacc cgtgcggcgt 633661 gggaacagga aaaacgatcg cagaagcgtt tgacagagcg tttgaagcgg ataaaacatc 633721 tatcttcggc ggcattatcg cgctgaaccg tgaagtggac aaggcaactg ccgaagcgct 633781 tcacaacatt ttcttagaaa tcatcattgc gccttcattc agccaagaag cgctcgacgt 633841 cctgactgcg aagaaaaatc tccgtctgct gacgcttgac gtatccgccg ctgttcaaaa 633901 ggaaaaacag ctgacatccg ttcaaggcgg gctgctgatt caagatttag atatgcacgg 633961 cttcgatgat gctgagatta gcattccgac aaaaagagag ccgaacgagc aagagtggga 634021 agacttgaag cttgcttgga aagtcgtgaa gcatgtgaaa tcaaatgcga ttgttctcgc 634081 gaaggacaac atgacagtcg gcgtgggagc aggccaaatg aaccgcgtcg gatcggcaaa 634141 aatcgcaatc gagcaagcag gggaaaaagc gaagggcagc gcgctcggtt cggatgcata 634201 tttcccaatg ccagatactg tcgaagaagc ggcaaaagcg ggcgttacag ccatcattca 634261 gccaggcgga tcgatccgag atgaggattc catcaaaaaa gcggatgaat acggcattgc 634321 catggtattc accggcatca gacacttcaa acattaaggg gatgaaaacg acgtgaatgt 634381 attaattatc ggtaaaggcg gaagagaaca tacgctggcg tggaaggcag cgcaaagcag 634441 cctcgtcgag aatgtatttg ccgctcccgg aaatgacggc atggcagctt ccgctcagct 634501 tgtaaacatt gaggaaagcg accacgcagg gcttgtctca tttgcaaaac aaaatcaggt 634561 cggcctgacc attgtcggcc ctgaggttcc tttaattgaa ggtctggtgg atgaattcga 634621 aaaagcgggc ttacatgtgt tcggtccgtc aaaagctgcg gcgatcatcg aaggaagcaa 634681 acagttcgct aaggatttaa tgaagaaata cgacattccg accgcagaat acgagacgtt 634741 tacatccttt gatgaggcga aggcatatgt gcaggaaaaa ggtgctccga ttgtgataaa 634801 agcagatgga cttgcagctg gaaaaggcgt tactgtggct atgacagagg aagaagcaat 634861 tgcgtgcttg catgactttc ttgaagatga aaagttcggt gatgcgagcg cgtccgttgt 634921 cattgaagaa tatctttctg gtgaagaatt ttctctaatg gcctttgtca aaggggaaaa 634981 ggtgtatccg atggtgattg cccaggatca caagcgggcg tttgacggag acaaaggccc 635041 gaatacaggc ggcatgggcg cctactcgcc agttccgcaa atttcggaag aaacggtccg 635101 ccatgctgta gaaacgatcg ttaagccggc tgcaaaagca atggtacaag aaggccgttc 635161 cttcactggc gttttgtacg ctggattgat gcttactgaa aacggctcga aggtcattga 635221 atttaatgcc cgtttcggcg atccggaaac acaggtcgtg cttccgcgca tggaatctga 635281 tctggtacag gtgcttcttg atcttttaga tgataaggaa gttgacttaa gatggaagga 635341 taccgcggca gtgagtgttg tgcttgcatc agaagggtat ccggaaagct atgcaaaagg 635401 cacgccgatc ggcagccttg cagcagaaac tgagcaggtc gtggtcttcc atgccggaac 635461 gaaagcagaa ggtggagagt tcgttacaaa cggggggcgc gtcgccaatg tgacggcttt 635521 tgatgaaacg tttgaagcgg ctagagaccg agtgtacaaa gcggttgatg aaattttcaa 635581 accgggactc tttttcagaa aagacattgg ggcacgcgct ttaaaggctg cccaaaaata 635641 agtgaggaaa acccgcagaa tagctgcggg ttttttgtta tcaaaaagcg ggatggcagc 635701 tagaagaaga aagcacaacg agcgtggttg gttttccatg ggccatcgag gtgtcaataa 635761 aatcctcaag cgtatgtacc gattcagtca cgacctttgt cacatagctg tacatccccg 635821 tgatgcggtg gttttctgct acatcaggat gcgatgttgc aaaggcggcg tagtgcttgc 635881 agcttttcgg ctccatgaga ataaaagcgg tgacatgctt gtttagtttt tcgtaacaga 635941 tattcgcgct gtagccggta atcactcctt tgtcttccag cttcctgaca cgctccgccg 636001 cgcttggcga gctgagtccg acaagctttc ccagctcaac catcgttaat ctgccgtttc 636061 gctgcaaatg cgagagaatc tgaaggtctg tatcgtccat ttgtctggct cctttacata 636121 tttaggcgaa tgaatgaaaa ttcctttgat cgtaaggtaa tgctgttgat ttaacttcat 636181 tgtagcatat ggatgccgtc ttattttttc tataataaag ccatcaatca gagagggggc 636241 atcatgttgc cagaattgca gcgctctatt acttggatac aagggacggc gttaacgatt 636301 ggggcggttt taggatgcgg gatattaatc ctgccgtctg tcaccgcgga cacggccggc 636361 cccgcttctt tatttgtttg ggtgttcatg tccttcttat ccttttttct tgtcggcacg 636421 ctggcccggc ttgtgaaaat agcgcctagc gcgggaggaa tcacggctta tgtgcagctg 636481 gcctttcaga aaaaagccgg ggctattttg ggctggatca tgttagggtc cgttccgatc 636541 ggcgttccca tcatcgcttt gactggcgcg cattacgtca gttacatcac agaggcggcc 636601 gattggcaga ttacattgat tgctggttgc atgctggcta tatctatttt gcttcatatg 636661 agagggattc aactatcagc aaacattagt acactcgtta tatgtgtcat cgtatttctg 636721 cttgtcactt ctattgctgt gtcattgcca cacgtcacga tagcagaatt caagccgttt 636781 cttccgcatg gctggtctgc cgctggatct gtttctgtta tgattttttt ctcttttgta 636841 ggctgggaaa tgattacccc gttggctgag gaatttcatc gtcctgaaaa agatgtcccg 636901 ctcagcttgt ttttggcagc gtcttgtgtg gcggggctgt atatcatgct gtcatttgtg 636961 accgtgggta ctcattcata tggagagaat ggagaaattg catcgcttgc catgctcatt 637021 tcaaaaggag caggagaaag cggtgtatat gtcacggtat gtttagcgct gtttattaca 637081 ttcgccacca tccatgccaa tattgccggt ttttcaagaa tggtgtacgc attggcgaga 637141 gaggggcaca tacccgtatt ttttggaaaa ctcagtgcga caaaacgtac gcctattcgc 637201 gttttgacag cgatggccgc agtgtttggc ttagtgcttg cagcgcatgg tctgtttcaa 637261 atcgatttga cgactctgtt gaaagggccg agcgcggctt ttatcgcatc ttacatatgt 637321 acaatggcgg cagcactgaa actgctgggc aggagagata taggctggtg gatggcgctc 637381 ggggcatttg tggcgtgcgc ggtgatttat tcattcagcg gctgggcact gctttatccg 637441 gcagtgctgg cagctgcagg atatttctat atgaaaacaa agggtgggca taaaaaaaag 637501 cttgatcacg ttttgtgatc aagcttttcc atttatccgt tttgatgctc gttatttcca 637561 gaatcgctgt gttgaaacat gtaggtcaca ggacagaagc gcaagattcc cgaacccgct 637621 ttcatggccc ccataaagat gtaaaagaga tgcattctgc accaaggttt tttcgtaaac 637681 tttgcactgg cggctgacat aatcgtcaat ccgcaggcga ttctgaacac ggcattgatg 637741 agactgatgt ttggcttcaa ggaaatccgc tccttttact taaaaaagtt ttttaatcga 637801 accttcaaaa atttgtaacg tttttatcgt gcgtgatgag gaaggatgtg ataccatgag 637861 tctaatacat gtaaaggaga gtatgtgaat gtccgaacgc acctttaact ggaaaaacaa 637921 agacatcagg gcacaggttg atgttgtaga ctcaaagctg cttccaacgc tccttttacg 637981 gaatgctctc gtcttaaatc catatgtaaa acaatggctg aaaaaaaaca tttggattta 638041 tcaggaccgc attgtttatg tgggtcatga acttccgaat agagccgaag aaattcatac 638101 gattgattgt gaaggaaaat acattgtgcc aggttatatt gaaccgcacg cacatccttt 638161 tcaaatatat aatccccaaa cactggcgga atatgtgtct caatacggaa caacgacatt 638221 cgtgaatgat aacttatttt tgcttttgca aagcggaaaa aagaaagcgc ttacgatttt 638281 gaatgaactc aaaaagcagc ctgtccagta tttttggtgg tcacgctatg acctccagac 638341 cgaggttctg aacgaggacc acgtccttcc atttgacgtc agaaaacagt ggattgaaca 638401 tccggatgtg attcaaggcg gagaaatgac cggatggcct cgcctggtag atggtgatga 638461 tttaatgctc cactgtatgc aagctacaaa gaaacagaga aaacgtattg aagggcattt 638521 tcccggcgct tctgataaaa cgcttacaaa aatgaagctg ttcggtgcgg attgtgatca 638581 tgaagcgatg acaggtgatg aagtgatgag aaggctggaa ctgggctatt atgtttccct 638641 tcggaactct tccattcgcc ccgatgtaag aaaaatcttg caagagctgc atgagaaggg 638701 cttccgctat tatgaccact tcttttacac gacagatggc gcaaccccga atttctataa 638761 aggcggcatg acaaacgagc tgattcgcat tgcgttagaa gaaggcgtac ctgcaatcga 638821 cgcctacaat atggcatcat ttaatatcgc aaagtattac caaatggatg attatttagg 638881 agttgtcgga ccgggcagac tggcatcgct aaacatactg gaagatccgt taaatccgaa 638941 tccagtgact gttctgtcaa aagggaccat tctgcgtgaa aacggctgtg atttgaaggc 639001 gtttacaaag acggactggc acaaaggcgg tcttgtcccg cttgagcttt catatgatat 639061 gacgatggat gacttgcagt tttctatgcc gatgggcgtg aaaatgcgga atgcggttat 639121 tatggagcca tatatgattg agatcgacaa ttcgatggaa cagctctcgt ttgaccatga 639181 tgaaagttat ttgacgatgc tcgacagaca cgggaaatgg cgcgtcaata cgatgataaa 639241 agggtttgcc tcaagcgtgc agggatttgt aagctccttt acgacgacgg gcgacattgt 639301 cgcgattgga aaaaataaag cggatatgct gctcgctttc gcccgcatga aagaaatcgg 639361 aggaggaatt gttttagcgg agaacggaaa cattctgcat gaaatcccgc ttgcgctgtg 639421 cggctgcgcc tcttcggaag cgtatgaaga cgtgcttgag aaggaacaaa agctgagaga 639481 tcttttgact gaaagaggct atgagttttg cgatcctatc tatacgctgc tctttttgca 639541 aagtacgcac cttccgtata tacgcattac gccaagagga atattcgacg tcatgaaaaa 639601 aactgtactc tttccatcga taatgcgtta aaatataaaa gagcagggag ccgacatatg 639661 aaaaaatgga tgacagtttg cgcgctgtgt ttcgtgtttt ttctgctggt atcctgccag 639721 cagaaggatg ctgtcccgga tactgcaaag aagctgaaag ctcctttaac ggggctaaag 639781 actgaacaga aagtgactga acgccgccct gttgctgttg tggtgaacaa tcacccgaag 639841 gcgaggccgc agtcgggtct gtctaaagcc gacattgtca tagaagcgct agccgaaggg 639901 caaatcacaa gatttctggc cattttccaa agccagatgc ctgaaactgt cggacctgtg 639961 cggagcgcgc gggaatattt cgtcactctc agcaatggct ttgacagcat atttgtccat 640021 cacggctgga gtcccggcgc caaaaagcag ctggaatccg gagctgccga ttatatgaac 640081 ggattggatt ttgacggaag cttattttgg agagctgatt tcagcaaacc gccccacaat 640141 tcctatacgt cttatgatta cataaaaaag gcggcagaac aaaagggtta taagctgaag 640201 caggaaacaa atccgctgct gtttcaaaca tcagatgcaa aacctgcaaa tgaatcttac 640261 aatgttcggg tagattatgg aacaaataac gttacaaatc ttgtcgaata caactatgat 640321 aaaaaagctg aattttatac aagaagctct gatggtgtca taacgacaga ccgggaaacc 640381 ggaaagccgg ttgcaatgca aaatattttc attgttgaag ccagccatca tattattgat 640441 caagatggaa ggcgggacat cgacttggaa tcaggaggaa aaggtctgtt gtttcagcac 640501 ggaaacgtca ttgaaacaga ctggaaacaa gtgaatggca gaattgtgcc ggtaaaagac 640561 ggcaagtggc ttccgtttgt gccaggaaag acttggatca atatcgtacc tgatcttgat 640621 gcggcttcca ttagtaaagg agaaggtgtg taacgatgca aatcgataaa ttacgcggca 640681 aagagctgga ccagttattt aactcgatct tatcgctgaa agacctggag gaatgttacc 640741 gattcttcga tgatctatgc acaattaacg aaattcaatc gctggctcag cgccttgaag 640801 tggcgcgcat gcttcgcgaa ggaaacacgt atcataagat tgaaacagaa acaggcgctt 640861 ccacggctac gatttcccgt gtgaaacgct gcttaaatta cggaaatgac gcttatgaaa 640921 tggcgcttga ccgtgtgaag gagacggaaa cagagtcttc ttccaaataa aaaaccgccc 640981 tgccgtctgg caagggcggt ttctttatga aacaaattga tggatcaggt tgtcgatatt 641041 gatgatactg ccatcctctt tccgatagac aacatgctcc ttggaaaaat gaatcggcga 641101 attaatccct gctgcggctg caaggttaaa tagtccctcg cgcaatgaaa taacgtagtt 641161 gcagacacga tgctgttttt cctcaacgct cagtgctttt tgcaatttcg gatctgtcgt 641221 cgccacacct gccggacagg tgttggtgtg gcagacgaga gcgcggatgc agccaacgga 641281 aaacatcatg ccgcgtgcga tgttaacaaa gtcagcgccg agggctaagg cgaccgcgat 641341 tttatcagga gtcaggagct ttccggaagc aaagattttc agctggctgc gcaagccgta 641401 ctgtttaaga agcgtgtcca caataggcag cgctgtcata atcggaaggc cgactgtatc 641461 cgcgagctcg taaaaggaag ctccggtacc gccttcactt ccgtcgatcg tgataaaatc 641521 cggatgcttt ccgcttttct gcatatgaga gaaaagctca tgcaattctt caggatgccc 641581 tgcgaccagt ttgatgccga ctggcttttg tccgacatct ctaagttttt caataaagtc 641641 gagcatttca ggagggtttg agaattcata aaagcggttc gggctgtcaa tcgactttcc 641701 aggttcgaca ttccgaatgt ctgccacttc ctctgatact ttggcgccgt ccacatggcc 641761 gccgcgggtt ttcgctcctt gtgccagctt tagctcaaac gctttaatct ggtcaatcct 641821 gctttttctt ttaaattcct cccacgaaaa ttccccgttt cttttgcgca cgccgaatag 641881 gcccggtccg atttggcaaa tgatatcggc gccgcccttt aagtgatatt cagacaatcc 641941 cccttcacct gtattcatcc aggtgccgcc tgccagatgg agcccttttg agagcgccgt 642001 aacagcccgt tctccaagag aaccgtagct catggcagac tggccgacta agcccttcac 642061 ataaaatggc ttctcgcatg tatgctcgcc aatcacctgt acatcatcag gatggagaaa 642121 atacgggtct gccttgatat gttcggcatg ctccttgcgt ttgaacagat tgtcagcatc 642181 cattttatag atttgggttt caatttttgg cgtttgattt acatgcattt cttccctttg 642241 ttttggaaac atagcgttac ggatataata gccaggttta tcaaaatctc ttacagatcc 642301 aaagcccatc attctgcttt tgtatttgcc ggagatgacg gtttgctcat attcctttcg 642361 tgaaaatggc tgctcttcat tgtcattgct gtataaatac tgtctgagct ccggcccgat 642421 tttttcaagg atataccgaa accttccgat gacgggatag ttgcgaagaa ttgagtgctc 642481 ctgctgtttt tcatccttta tgtagatcca ggcaaacaag acgatcggga tagcgatgat 642541 cccaatgata aatgcgatga gtgctattat gatggtttcc atctctcagc ctcccttttt 642601 atgtaaccat ttccacagta gaacactttc caaacaatag cagaaggaat ctggtgaaaa 642661 atgtgtgctc ctgccgatac aggactcacc atgcaggtac tgccatatgc tctctttttt 642721 tatgaaaaaa gaatcaaaac acctttttca gtgaataacg agattaacgg ctttttccgt 642781 ttttccgcgc tatgtgaatt tgttataatg tttaaatggt aacaaacgaa tggaggaacg 642841 tatgacgtgt acgatgtaac ggagtggaag catgtcttta aactcgatcc aaataaagat 642901 ttgcctgacg aacagctgga gattctttgc gaatcaggaa cggatgcggt cattatcgga 642961 ggaagcgatg gtgtgacaga ggataatgtc ctgcggatga tgtctaaggt aagacggttt 643021 ttggtgccgt gtgtcctaga ggtatcagcg attgaagcga ttgttcccgg ctttgactta 643081 tattttattc cgagtgtatt aaacagcaaa aacgcggatt ggattgtcgg aatgcaccag 643141 aaagccatga aggaatacgg agaactgatg tctatggaag aaatcgtggc ggagggctac 643201 tgcatcgcaa atccagattg caaagccgcg gcactgactg aagcggacgc cgatctgaat 643261 atggatgata ttgtcgccta tgcgcgtgtg tcggagctgc tgcaactgcc gattttttat 643321 ttagaataca gcggcgtgct tggagacata gaagctgtca agaaaacgaa ggctgtattg 643381 gaaacgtcca ccttgtttta cggcggcggc atcaaggatg cggaaacggc caagcagtac 643441 gcagagcatg cggacgtgat cgttgtaggc aatgcggtgt atgaagattt tgacagggct 643501 ttgaaaacag tagcggctgt gaaaggcgag tagtaaattg tacggatttg gtttatgata 643561 gaacgtatgt tttgtatagg cgggtgaaca aattttgaat tatattagca atcaattact 643621 aagcggttta aaccccgttc agcaggaagc agtcaaaaca acggacgggc ctcttttgct 643681 gatggcggga gcgggtagcg gaaagacgcg tgtcctgacc catagaattg cttatttaat 643741 ggcagaaaag catgtggcgc cgtggaacat tctggcgatc acatttacaa ataaagcggc 643801 acgcgaaatg aaagaacgtg tggaaagcat cctcggaccc ggcgcggacg atatctggat 643861 ctccacattc cacagcatgt gcgtgcggat cttgcgcaga gatatcgacc ggattgggat 643921 caaccgaaat ttctccatcc ttgatacggc tgaccagctt tcagtgatca aggggatttt 643981 gaaggagcgc aatcttgatc cgaagaagtt tgacccgaga agcatcctcg gcacgatcag 644041 cagtgcaaaa aacgaattga ccgaaccgga ggaattctct aaagttgctg gcggctacta 644101 cgatcaggtg gtcagcgatg tatatgctga ttatcagaag aagctattga aaaaccagtc 644161 gctcgatttc gacgatttaa ttatgacgac gattaaactg tttgacagag tgcctgaagt 644221 gcttgaattt tatcagcgca aattccagta catccacgtt gatgagtatc aggatacgaa 644281 cagggcacaa tacatgctcg ttaagcagct tgccgagcgt ttccagaacc tttgcgttgt 644341 gggggattct gatcagtcaa tctacagatg gcgcggcgcg gatatcacca acattctttc 644401 atttgaaaaa gattatccga atgcaagcgt gattttgcta gaacaaaact atcgttcaac 644461 gaaacggatt ttgcgcgcgg ctaacgaggt cattaaaaac aactctaacc gcaaaccgaa 644521 aaatttgtgg acggaaaatg atgaaggcat caagatttcc tattatcgcg gtgataatga 644581 gttcggtgaa ggacagtttg tggccggcaa aattcatcag cttcacagca caggcaagcg 644641 gaagctgtcg gatatcgcca tattataccg gacaaacgcg cagtcccgtg tgattgagga 644701 aacgcttctc aaagcgggct tgaactataa cattgtcggc ggcacaaagt tctatgacag 644761 aaaagaaatt aaagacattc ttgcgtacct gcgcctcgta tccaatccgg atgacgatat 644821 cagtttcacg cgcattgtca atgtgccgaa gcgcggagtc ggcgcgacat cacttgaaaa 644881 aatcgcttcg tatgcggcca taaacggctt gtcctttttc caagcgattc agcaggttga 644941 ttttatcggc gtcagtgcca aagcggcaaa cgcgcttgac agctttagac agatgattga 645001 aaacctgacc aatatgcagg attacttatc cattacagag ctgacagaag aaattcttga 645061 taagacggaa tacagagaaa tgctgaaggc tgagaaatcg atcgaagccc aaagccgttt 645121 agaaaatatc gacgagttcc tgtctgttac gaaaaacttt gaacagaaaa gtgaagacaa 645181 gacactcgtt gcgttcctga cagacttggc attgatcgca gatattgatc agctcgatca 645241 gaaggaggaa gagtcaggcg gcaaggatgc gatcaccctg atgacactgc acgccgcgaa 645301 aggactggag tttccggttg ttttcttgat ggggcttgaa gaaggcgtct tcccgcatag 645361 ccgttcactc atggaggaag cggaaatgga agaagaacgc cgccttgcgt acgttgggat 645421 tacaagggcg gaacaggagc tttatctgac caatgctaaa atgcgcacct tgtttggccg 645481 gacaaatatg aacccggaat ctcgcttcat tgctgaaata ccggatgatt tattggaaaa 645541 cctaaatgag aaaaaagaaa caagagcgac gtctgcgaga aaaatgcagc cgagacgcgg 645601 ccctgtttca cgcccggtat cctacgccag caaaacaggc ggcgacacct tgaactgggc 645661 agtcggagat aaggcgggcc ataaaaaatg gggaacagga actgtcgtca gcgtgaaagg 645721 cgaaggagaa gggacagagc ttgatattgc cttcccgagc cctgtcggcg tgaaacgcct 645781 gttagcagca tttgctccta ttgaaaagca gtaattgaag aggaaaggaa gaagcagatg 645841 gacaaagaaa cagcgaagca gcgggcagaa gaactgcgcc gcaccatcaa caagtatagc 645901 tatgaatatt acaccttaga tgaaccgagc gtcccagatg ccgaatacga cagattgatg 645961 caggagctga tcgcgatcga ggaggagcac ccagacctca gaacgcctga ctctcctacg 646021 cagcgcgtcg gcggagccgt gcttgaagcg tttcagaaag tcacccacgg cacaccgatg 646081 ctcagtctgg gcaacgcctt taatgctgat gatcttcgtg atttcgaccg ccgtgtgcgc 646141 cagtccgtcg gcgacgatgt ggcgtataat gtggagctga aaatagacgg tcttgctgtt 646201 tctctccgtt atgaagacgg ctattttgtc agaggggcca caagaggtga cgggacgacg 646261 ggagaggata tcacggagaa tctgaagacg atccgcaata tcccccttaa aatgaaccgt 646321 gagctgtcga tcgaagtgcg cggcgaggcg tatatgccga agcgttcgtt tgaagcactc 646381 aatgaggaac ggattaaaaa tgaggaagaa ccgttcgcca atccgcgaaa tgccgcggcg 646441 ggatctctca gacagctcga tccgaaaatt gcagcgaaac gaaacctcga tatcttcgtc 646501 tacagtatag cggagcttga cgagatgggt gtagagacgc aaagccaagg gcttgatttt 646561 ctcgacgaac tcggatttaa aacgaatcag gaacgaaaaa aatgcggcag catagaagaa 646621 gtcattacgc tgatcgatga gcttcaggcg aagcgcgcgg acctgccgta cgaaatagac 646681 ggcattgtca ttaaagtcga ttctctcgat caacaggagg agctcggttt tacggcgaaa 646741 agcccgcgct gggccatcgc gtataagttt cctgctgaag aggtcgtgac gaagcttctc 646801 gatatcgaat taaatgtcgg cagaacgggt gtgattacgc cgactgcgat tcttgagccg 646861 gtaaaagttg ccggcacaac ggtctcaaga gcatcccttc ataacgaaga tttaattaaa 646921 gagaaggaca ttcggatttt ggataaggtt gtcgtcaaaa aagcgggcga tatcatcccg 646981 gaagttgtga atgtcctcgt tgaccagcgc acaggagaag aaaaggaatt cagcatgccg 647041 acggaatgtc ctgaatgcgg cagtgaactc gtccggatcg aaggagaagt ggcgcttcgc 647101 tgcattaacc ctgaatgtcc ggcgcaaatc cgggaagggc ttatccattt cgtttcccgg 647161 aatgccatga acattgatgg gctcggcgaa cgagtgatca cacagctgtt tgaggaaaac 647221 cttgtccgca atgtggcaga tttatataag ctgacgaagg aacgagtcat ccagctcgag 647281 cgcatgggcg aaaagtccac tgaaaacctg atcagctcca tccaaaaatc aaaagaaaat 647341 tcgttagagc gcctgctgtt tgggcttggc atccgtttta tcggatcaaa ggccgcaaag 647401 acgcttgcca tgcattttga aagcttggag aacctgaaaa aagcctctaa agaggaactt 647461 ctcgcggtag atgaaatcgg tgaaaaaatg gctgatgctg tgatcaccta ttttcataaa 647521 gaagaaatgc ttgaactctt gaatgaactt caggagctgg gcgtaaacac gctctacaaa 647581 ggcccgaaaa aagtaaaagc agaggacagc gactcttact ttgctggtaa aacaattgtt 647641 ctgacaggaa agctggaaga gctgtcaaga aacgaagcca aagcgcaaat cgaagcgctg 647701 ggcggaaagc tgactggaag cgtcagcaaa aacacagact tagtcatcgc cggagaagcg 647761 gcgggaagca agctgacaaa agcacaagag ctgaacattg aagtgtggaa tgaagaacag 647821 ttaatgggag agctaaagaa ataagaggag tgttttctat tgaaaaagac gttggcattg 647881 gcggcaacgg cggcagtatt aatgctgtct gcctgctcgt caggtttcgg gggggagaag 647941 gaggaagaga ttacgcaaaa gacggcgaaa tcgtcagaaa aagcgattgt cccgaaatat 648001 aatatctctg actcctatta caaaatggtg ctgccgttta aggcaggcaa agcgcgcggc 648061 ttaacaacgg aacagctgaa tacaaggctg gacattgacg aatttgaaac agggctgatg 648121 cgccttgccc aagattcttt ctcaactgac gattatctgt tccaagaagg acaatattta 648181 gatgaggata cagtattaag ctggctggca cggaaaaaaa cgggctctga tttgaaaaaa 648241 gccgaaaaag aagataagaa cttcaaaaat gaaggcttga acccggcgct cccgagttct 648301 ggttcaacag aagaaaagaa cgaaagcagc ccaatttatt tagcatccat gcttgagcac 648361 gattatttag tcagaaaaga caagaattct atccagcttg gcggcgtcat gatcggactg 648421 gcgttaaact cagtgtatta ctatcgtgaa aaaactggcg acccgcaaaa agaagtggag 648481 attaaagaca gcacgcttcg ccagcaggga gaaaaaattg cacaggaggt tattaaccgc 648541 ctccgcaaaa aagataactt gaagaatgtg ccgattaccg tggcgctcta caagcaggcg 648601 tcaaaaacat cgattgtgcc ggggaacttc atcgccaaaa cagaggtcaa agcaggctct 648661 actgatatct caaattggga tgacatcaat gaaaaatatg tattctatcc ggcggataca 648721 accacagcag aaaagtaccc ggatgacacc gaggtcttta agcggttcaa aaactcaatt 648781 gaagaatatt tcccgaacta tacaggcgtt gtcggtacag cgctgtatga aaatgatgaa 648841 atgaagaaaa tgaagattga cataccaatg caattctacg gaaaaagtga agttgtcgcg 648901 tttacccagt tcttaacggg tgaagtgatg gactactact ctaagagctc agttgatgtc 648961 gaagtcaata tcacgtcctc agacggacag gaagcggtca ttatccgcaa tgccggagat 649021 aaagagccga ctgttcacat ttatgactga tagaaaaccc ttgtgccata ttggcacaag 649081 ggtttttatg ttacaattaa caggaaaagg gaaaatattt tcacttctgc cgaaacacaa 649141 atcaagggga ggtatgttga tgctggaaat cgtgtgaaaa caatcattat caaatctata 649201 gcaatgaaag gatgttagac gtgcataaag atatcaaaaa aatatttcat gaagagcagg 649261 ttttggcaga agctgcagcg agatacggtt tctcaaaaga tcaggtgcgt tttctggctg 649321 atgcggaaaa ctatgtatat gaatgtatga aagacaatca accttatatt ttaaagatta 649381 cccatacgat tcggagatct tctgattata tgatgggaga gatggaatgg ctccgtcacc 649441 ttgcaatagg gggaatttca gtagccaaac cgctcccgtc gctgaacgga aaagacgtag 649501 aagcagtgcc ggacggaaac ggcgggtcat ttttattgag agtgtatgag aaagcgccgg 649561 ggcaaaaagt ggatgaatcg gactggaatg aaacgctatt ttatgagctt ggcagataca 649621 caggcagcat gcacagcctg acaaaaagct acaaattgag caatcccgct ttcaaaagac 649681 aggaatggga tgaagaggag caattaaagc tgagaaaata tgtgcctgaa gatcagataa 649741 aggtgtttca gcaagccgat tctttgatga atgaactgcg gaggctcccg aaaagccagg 649801 acaactacgg cttggtgcat gcggatctgc accatggcaa ttttaactgg gatcatggca 649861 aaatcacggc atttgatttt gatgatatcg gctacaactg gtttgttaac gatattagca 649921 ttcttctcta caatgtcctg tggtatcctg ttgtgccata tgatgataaa gctgcgttta 649981 cagaagaatt tatgacgcat tttatgaaag ggtactggga ggaaaatgag cttgaccctg 650041 catggctgat gataatacct gatttcctcc gccttcgcca tatgctgatt tacggattgc 650101 tgcatcagat gtttgacctt aacacaatag gagaagagga aaaagaaatg ctggccggtt 650161 tcagaagaga tatagagaat ggcacgccga ttacagcatt tgatttttca gcactggtgt 650221 agatagaaaa agccaatggg attccagtcc cattggcttt tataatgtat cacacttcac 650281 gccgactacg ccttcaatgg ctttaatgtc atagtagaca tcggtcgtgt atctgttttt 650341 atggacgcgg accttcactt ccataattgg aaaatccttt tcgcctaggt cgtcgatccg 650401 aacggagtgt gctttgatat ctcttctttt catttctttt aaaatctctg tcattttgtc 650461 tttatcagaa agtgacattc tgatgcggat gtctttttcc tgcaggcggt cggggccgat 650521 ttttctgacc acccatggga gaaattccac actgatcagg atgaacagaa gactggcaaa 650581 cgcttcttta taaaaaccgg ctcccgtagc aagcccgagc cccgctgccc cccagatcat 650641 ggccgatgtc gtcaggccgg aaatgacatc attgcttttt cgcaggatga caccggcgcc 650701 gataaacccg acgccggaga tgatttgtgc cggcagacga agcggatcca tcatgatgcg 650761 gtagtattta gggaaatgat atgccgcatt aatactgacg atcgtcagca tgcatgagct 650821 gactgcgatg acaatacagg tttttaatcc gagcggctta ttttttaatt cgcgttcaag 650881 cccgatgacc atgccaatca atgtggcaat gcccaatttc aataaaatat caggatcaat 650941 ataccagctc aacagcaaac ttcccccttc tctatggtgt ttttaaataa atatgatttt 651001 ctcacagtat ttatagcaaa acaagagcac aaaagccacc aagctgcgct tgatggctta 651061 ttgcttactt tttgcgtttt aacagctttt ccatgacacc gaataatcgg taagaggctt 651121 ttgcaggacg ttttgtgatc atgctgacaa tgatgccggc aatcatactg agaataaacc 651181 cagggatgat ttcgtacaca ccggttgatt ttgccaggcc ggttgtaatc cagatcaaca 651241 cggtcgcagc cccgacaatc atggcagcaa gcgcgcccca ttcgttcatt cgtttccaat 651301 acagactgag cagaatcgca ggcccgaaag ctgaaccgaa gccggcccaa gcgtatccga 651361 ccaaatcaag aatggtgctg ttcgggttca atgacaagag taccgcgata acggcaatga 651421 ctaagacgga caatcgcccg atcatgacca attctttatc agaagctttt cgtctgaaaa 651481 atgaccggta taaatcctct gttacagcac ttgctgtgac caagagctgt gaggaaatcg 651541 aactcatgat ggcagccaaa atagctgaca ataagaaccc tgtaattaat gggtggaaca 651601 agattttaga gaagataatg aaaatcatct ccggatcttt tacagcaact ccgaatttat 651661 gggcgtatgc aacaccgatt aaacccgtca gcacggaacc tagaactgta atgatcatcc 651721 agctcatgcc gattcggcgt gcaggtttta aatctttaat gtctttaatg gccataaatc 651781 ggacgatgat atgaggctgg ccgtagtagc ccaaccccca ggctaaatag gaaataatgc 651841 taatgacgct cgcgccttta aaaatatcca ataaatgtgg attaacagcg tcgatttcat 651901 ggaaagtcgg agcaacgccg cccacatggg taaaagcaac gatcggcaca agcactagtg 651961 ctgcaaacat gatcgcaccc tgcacgaagt cagtcagact gacagcaagg aaaccgccaa 652021 acagtgtgta taacacgaca actgcggtgg tcagaaacag gcctaatttg taatccgcac 652081 caaaagcaga ttcaaacagc cgtccgccag ataccatacc ggaagaggta tacaatgtga 652141 aaaagatcat gatgatcaat gcagatacga ttttcagcag tgatgaagaa tgctggaatc 652201 gtttatcaaa gaaatcagga attgtaatcg catcatctgc cgcttctgta taagcacgca 652261 gccttggagc cagcagcaag taatttgagt acgccccgat tgtaagacct aaagcaagcc 652321 ataaggtgga cagccctgtc gcaaacatcg cgccgggaac acccatcagc atccatccgc 652381 tcatatcggc cgcgccggca gacaaagcag taacgaatgg tccgaggcct cttcctccaa 652441 gcatgtaatc attgatgtca gtggttttct tgaatgcata ccagccgatt aacagcatgg 652501 caataaagta aattcctaaa gatataataa tttcaatact cacgttttac cctctcttca 652561 tttctaataa tgttgcatca cctctcaaat tgatggtgcc agttaagcag cctggcgtaa 652621 gtgcaaaaca aaagaaattc ttttgcgggt gcacttggta acttaaccta acaaagtatt 652681 cccggccatt caagcgatga aacattgatc ataagctgga aataccgttg caaacctaga 652741 agggaataaa gaataaaacg ctttcaaaaa ataattaaag taaaaatatt cagaaaaata 652801 tttcgtttct ccttctcctc attttagtat aaaatatata gggtattgtt tcgaaaacac 652861 aggcctgtct caaggcgttt tgttgcttta aagggcttgt ttttgatatg atcagtatta 652921 tatgacttaa cggagaaata tgtggaggtg gatcatatgt cacgaatttc aatagaagaa 652981 gtaaagcacg ttgcgcacct tgcaagactt gcgattactg aagaagaagc aaaaatgttc 653041 actgaacagc tcgacagtat catttcattt gccgaggagc ttaatgaggt taacacagac 653101 aatgtggagc ctacaactca cgtgctgaaa atgaaaaatg tcatgagaga agatgaagcg 653161 ggtaaaggtc ttccggttga ggatgtcatg aaaaatgcgc ctgaccataa agacggctat 653221 attcgtgtgc catcaattct ggactaaagg agggacacaa gaatgtcatt atttgatcat 653281 aaaatcacag aattaaaaca gctcatacat aaaaaagaga ttaagatttc tgatctggtt 653341 gatgaatctt ataaacgcat ccaagcggtt gatgataagg tacaagcctt tttggcatta 653401 gatgaagaaa gagcgcgcgc atacgcgaag gagcttgatg aggcggttga cggccgttct 653461 gagcacggtc ttcttttcgg tatgccgatc ggcgtaaaag ataatatcgt aacaaaaggg 653521 ctgcgcacaa catgctccag caaaattctc gaaaactttg atccgattta cgatgctact 653581 gtcgttcagc gccttcaaga cgctgaagcg gtcacaatcg gaaaactgaa catggacgaa 653641 ttcgccatgg ggtcatctac agaaaactca gcttacaagc tgacgaaaaa cccttggaac 653701 ctggatacag ttcccggcgg ttcaagcggc ggatctgcag ctgcggttgc tgcgggagaa 653761 gttccgtttt ctcttggatc tgacacaggc ggctccatcc gtcagccggc atctttctgc 653821 ggcgttgtcg gattaaaacc tacatacgga cgtgtatctc gttacggcct ggtcgcattt 653881 gcgtcttcat tggaccaaat cggaccgatt acacgtacgg ttgaggataa cgcgttttta 653941 cttcaagcga tttccggcgt agacaaaatg gactctacga gtgcaaatgt ggacgtgcct 654001 gattttcttt cttcattaac tggcgacatc aaaggactga aaatcgccgt tccgaaagaa 654061 taccttggtg aaggtgtcgg caaagaagcg agagaatctg tcttggcagc gctgaaagtc 654121 cttgaaggtc tcggcgctac atgggaagaa gtgtctcttc cgcacagtaa atacgcgctt 654181 gcgacatatt acctgctgtc atcttctgaa gcgtcagcga accttgcacg ctttgacggc 654241 atccgctacg gctaccgcac agacaacgcg gataacctga tcgaccttta caagcaaacg 654301 cgcgctgaag gtttcggaaa tgaagtcaaa cgccgcatca tgctcggaac gtttgcttta 654361 agctcaggct actacgatgc gtactacaaa aaagcgcaaa aagtgcgtac gttgattaag 654421 aaggatttcg aggacgtatt tgaaaaatat gatgttattg ttggaccgac tacaccgaca 654481 cctgcgttta aaatcggtga aaacacgaag gatccgctca caatgtacgc aaacgatatc 654541 ttaacgattc cggtcaacct tgccggcgta ccgggaatca gtgtgccatg cggattagca 654601 gacggacttc cgctcggcct gcaaatcatc ggaaaacact ttgatgaaag cactgtatac 654661 cgcgttgctc atgcatttga acaagcaaca gaccatcata aagcaaaacc tgaactgtaa 654721 ggggtgaaaa gaattgaact ttgaaacggt aatcggactt gaagtccacg ttgagttaaa 654781 aacaaaatca aaaattttct caagctctcc aacgccattc ggcgcggagg cgaatacgca 654841 gacaagcgtt attgacctcg gatatccggg cgtcctgcct gttctgaaca aagaagccgt 654901 tgaattcgca atgaaagccg ctatggcgct caactgtgag atcgcaacgg atacgaagtt 654961 tgaccgcaaa aactatttct atcctgacaa cccgaaagcg tatcagattt ctcaatttga 655021 taagccaatc ggcgaaaacg gctggatcga aattgaagtc ggcggcaaaa caaaacgcat 655081 cggcatcacg cgccttcatc ttgaagagga tgccggaaaa ctgacgcata cgggcgacgg 655141 ctattctctt gttgacttca accgtcaagg aacgccgctt gttgagatcg tatcagagcc 655201 ggacatccgc acgccggaag aagcgtacgc atatcttgaa aagctgaaat ccatcatcca 655261 atatacaggc gtttctgact gtaaaatgga agaaggctca cttcgctgtg acgccaatat 655321 ctctcttcgt ccgatcggcc aagaggaatt cggcacaaaa acagaattga aaaacttgaa 655381 ctcctttgcg tttgttcaaa aaggccttga gcatgaagaa aaacgccagg agcaggttct 655441 tctttccggc ggcgtcatcc agcaagaaac tcgccgttat gatgaagcaa cgaagaaaac 655501 cattcttatg cgtgtcaaag agggatctga cgactaccgt tacttcccag agccagatct 655561 agtcgagctc tacattgatg atgaatggaa ggaacgcgta aaagcaagca ttcctgagct 655621 tccggatgag cgccgcaagc gttatatcga agagcttggc ttgcctgcat atgacgcaat 655681 ggttctgacg ctgacaaaag aaatggctga tttcttcgaa gaaaccgttc aaaaaggcgc 655741 tgaagctaaa caagcgtcta actggctgat gggtgaagtg tcagcttacc taaacgcaga 655801 acaaaaagag cttgccgatg ttgccctgac acctgaaggc cttgccggca tgatcaaatt 655861 gattgaaaaa ggaaccattt cttctaagat cgcgaagaaa gtgtttaaag aattgattga 655921 aaaaggcggc gacgctgaga agattgtgaa agagaaaggc cttgttcaga tttctgacga 655981 aggcgtgctt ctgaagcttg tcactgaggc gcttgacaac aatcctcaat caatcgaaga 656041 ctttaaaaac ggaaaagacc gcgcgatcgg cttcctagtc ggacagatta tgaaagcgtc 656101 caaaggacaa gccaacccgc cgatggtcaa caaaattctg cttgaagaaa ttaaaaaacg 656161 ctaataaaaa agcagccctt agaggctgct ttttttatgg tcaaattgag ataaagacaa 656221 gatgagggcc cgaagccttt caacttcttt gtcgttggtt ccggccaaat tggacagcat 656281 gcctttaata atcggcttgc gcggtttatc ctgagtcaat tcttcctcga taacatcaag 656341 tgacacggtg atatcctcgg gcagcgtgct gttttctttc actttctgaa tgtcctcaag 656401 cagctggtct tttcccgcag gcatcgggtt aaaaatgtct tttgatacaa tcggattgag 656461 tgcagaacgg ctcagcccct gtacaagatc atccagtctc tcaataataa aggctgagat 656521 ttcttctgca tcgatattaa gctcaccgtt aaataccatc acgttcatat aggaatgcac 656581 aatgcctctt gccatgatgg acagatctgc gacataccgc tcgattcctt cgccatagga 656641 taccagcaag gcgttccggt acagcttatc cgtctccatg gttactttgt aaaagtattg 656701 cttgatttct tgattttccg gaatgatatt ttcggtaagc aaaagaacga taaaatcttt 656761 atgatcgcga aaatcctcaa attgagcgcc aatttgcttt tttaacactt ccttaggcgg 656821 ctttccggcg agatcttctt ctatattttt cattttgttc atagacatac cgatataata 656881 ttcacaggca gataacagca gcgcttcttt cgatttgaag tgcaaataaa aagcgccctt 656941 cgaaatgccg cattcactgg cgatttcttg gatcgtcgta gctgcgaatc cttttttcgc 657001 aaataaacga atgctggttt ttatgattct ctcttttttt tcattcatga cgtgcttccc 657061 cttaatcctt gaaaaattta gtaaaatttt ctggtatatg agttgacgtt gttgcgttat 657121 aacgtttagt attatataga atgaccagtc agtcaataaa aaatgtaatg gaggatatga 657181 tgaaccacgt tattaatttc gttctgaaaa acaaattcgc cgtatggctg atgacgatta 657241 ttgtaacggc agccggcttg tatgcgggta tgaatatgaa gcaagagtct attcctgacg 657301 tgaacatgcc ttacttgacg atcagcacga catatccggg tgcaacacca agccaagtgg 657361 ctgatgaagt gaccaaaccg gttgaacaag ccgtacagaa cttggacggt gtcagcgttg 657421 tgacgtcgac gtcctatgaa aacgcatcgt cggtcatgat tgaatatgat tatgagaaag 657481 atatggacaa agcgaaaaca gaagcagctg aagcgttaga aaacgtcaac ctgcctgatg 657541 acgcgaagga tccggagatt tcacgctaca gcttgaactc attcccgatt ctgacgctga 657601 gcgtgtccag tgataaagat aatctgcaag agctgacgaa acaagtggag gacagcctcg 657661 tttctaagct tgaaggcata gaaggcgttg cgtccgtcca agtatcaggc cagcaggtgg 657721 aagaggttga attctctttc aaagaagaca aactgaagga atacggcctt gatgaagata 657781 cagtcaagca agtgattcaa ggttcagatg tgacaactcc gcttggattg tacacattcg 657841 gaaatgaaga aaaatctgtc gtcgtcagcg gcgatattga aacaattaaa gatttgaaga 657901 atatgagaat cccgacggca tctgcttcaa gtgcaggcag cagcgcagca tctcaagcag 657961 gtgcgcagag tgctcaagca gcccaaagcg cgcaagcggc agcacaggtg cagcaaagcg 658021 caagcacagc agtgccgacg gtcaagcttt ctgacattgc tacaattaaa gatgtgaaaa 658081 aagctgaatc cgtttcacgc acaaatggca aagacagcat cggcatcaac atcgtcaaag 658141 caaacgatgc gaatacggta gaggttgccg acgatgtcaa agctgagctg aaaaagttca 658201 aagaagacca taaaggcttc aattacagcg caactctcga catggcggag ccgatcacac 658261 agtcagttga cacgatgtta agcaaagcca tcttcggtgc tatttttgcg attgtgatta 658321 ttctcttatt cttaagagat atcaaatcaa cattaatttc tgttgtttca attccattat 658381 cattgctgat cgcactcctt gtgctgcagc agcttgatat cacattgaat attatgacgc 658441 tcggcgcaat gaccgttgcc atcggacgtg tagtcgatga ctccatcgtt gtgatcgaga 658501 acatttaccg ccgcatgaga ctcaaagatg agccgctccg cggaaaagcc ttggttcgtg 658561 aagcgacgaa ggaaatgttt aaaccgatca tgtcatcaac gattgtgaca atcgcggtat 658621 tcctgccgct cgcacttgta ggcggacaaa tcggtgaatt gtttattcca tttgccttaa 658681 cgattgtttt tgcgcttgcc gcatccctag tgatttcaat cacgcttgtg ccgatgctcg 658741 cacacagcct gttcaaaaaa tcattaaccg gtgcgccgat taaagcgaaa gaacacaaac 658801 ctggcagact tgcaaacatc tataaaaaag tattgaactg ggcgctgagc cacaaatgga 658861 tcacgtctat catcgcggtt ctgatgctcc ttggaagctt gttcctcgta ccgttaatcg 658921 gtgccagcta cctgccgtcc gaggaagaaa aaacgatgca gctcacatac agcccagaac 658981 cgggtgaaac gaaaaaagaa gccgaaaatg aagctgaaaa agcggaaaaa atcctgcttg 659041 accgcaagca tgtcgatacg gttcagtatt cattaggctc tggcagcccg cttgccggag 659101 gagattctaa cggtgcgtta ttctatatca aatatgaaag cgacacacct gactttgata 659161 aagaaaaaga taacgttctg aaggaaatcc aaaagcaatc tgaccgcgga gaatggaagt 659221 cacaggactt cagctcttca ggcaataata acgaattaac atactatgtg tatggcgatt 659281 ctgaaaacga tattaaagac acggtcaaag acattgaaaa aatcatgaaa gatgaaaagg 659341 atctgaaaaa cgtaaattca ggcctttcca gcacatatga tgagtacaca tttgtcgctg 659401 accaagaaaa actaagcaag ctcggtttaa ccgcgtctca aatttctcag gccttaatgt 659461 cacaaacatc gcaagaaccg ctcaccactg tgaaaaaaga cggcaaagag cttgatgtga 659521 acattaagac agaaaaagac gagtataaga gtgtgaaaga tttagagaat aaaaagatca 659581 cttccgcgac tggccaggaa gtcaaaatcg gcgatgtggc aaaagtgaaa gaaggatcaa 659641 catcagatac cgtgtcaaaa cgtgacggaa aagtctatgc agatgtcaca ggtgaggtta 659701 cctctgacaa cgtcacagcc gtatcagctg ctatccagaa gaaaatcgat aagcttgacc 659761 accctgataa cgtatcgatt gacacaggcg gcgtatcagc ggatatcgct gattccttca 659821 cgaagctcgg tttagcgatg ctggcagcaa tagcgatcgt ttaccttgtg ctcgtgatta 659881 ccttcggcgg agcactagcg ccatttgcga ttctgttctc attgccgttc acagtcatcg 659941 gtgccctggt cggactttac gtatcaggtg aaacgatcag tctgaacgcc atgatcggta 660001 tgctcatgct gatcggtatc gttgtcacga atgccattgt cttaattgac cgcgtgattc 660061 ataaggaagc ggaaggcctg tctacgagag aagcgctcct ggaagccggc tctacacgac 660121 tccgtccgat cctgatgaca gccattgcga caatcggcgc cttgattcca ttagccctcg 660181 gcttcgaagg cggaagccag gtcatttcaa aaggactcgg cgtaacggtt atcggcggtt 660241 taatcagttc aacgcttctg acgctcctga tcgtgccaat cgtatatgaa gtattggcga 660301 agttccgcaa gaaaaaaccg ggaacggaag aagagtaaaa aacaaaaagc ctcagctctg 660361 ctgaggcttt cagcttgttg aaaaaccctc gcattcgttg tcaggtctgc gcgtcggtgc 660421 tcacgaattc tacattcgct ccgctccaat gctccccctt cctagactac aagggttttc 660481 aatcaagctg aaagaatgtt aaggatgaca aaagctcaaa acaagaatca gttttgagct 660541 tttgtgcgtt ttcacctgta agattatgta cattttgttg cgattttttt aactcatagt 660601 ataattaaag gttgttagtg taaaaatgga tcggatactc ttaagtagga tgatgagata 660661 atgaaacgtg cacgcataat atacaatccg acttcaggac gggagatctt taaaaagcat 660721 cttgcccagg tcctgcaaaa atttgaacaa gccggctatg aaacctccac ccatgcgacg 660781 acatgcgcag gagacgctac acacgctgcc aaggaagcgg cattgcgtga gtttgacctg 660841 atcattgcgg caggcggaga cggaacgatc aacgaggtcg tcaacgggct tgcgccttta 660901 gacaatcgtc cgacactcgg tgtgattcct gtcggcacaa cgaacgactt cgccagagcg 660961 ctcggaatcc cacgcgagga tattttaaaa gcggcagata cggtcattaa cggcgttgcc 661021 cgcccgattg atatcggaca ggtcaacggc cagtatttta tcaatatcgc cggcggaggc 661081 cgtctgacgg agctgacgta cgacgtgcca agcaaactga aaacaatgct cggccagctt 661141 gcttattatt taaaaggaat ggaaatgctg ccttcacttc gtccgacaga agtcgagatt 661201 gaatatgacg gcaagctgtt tcaaggtgaa atcatgctgt ttttggtcac gctgacaaac 661261 tccgtcggcg ggttcgaaaa gctcgcgccg gattccagcc tgaatgacgg catgtttgat 661321 ttgatgatac taaagaaagc aaaccttgct gaatttatca gggtcgccac gatggcgctt 661381 cgcggagaac acatcaacga ccagcacatt atttatacaa aagcgaaccg cgtgaaagtc 661441 aatgtatcag aaaagatgca gctgaacctg gacggcgagt acggcggcat gctgccgggc 661501 gaattcgtga atctgtaccg gcacattcac gtcgtcatgc cgaaggagaa agcggaacag 661561 ttggatgact aaaacttggc ttggtaagcc aagctcagaa tgttgacaaa atcctaaaac 661621 agttttcgtt ttaggatttt gtcatctttt cagcgtgatt gaaaaccttt gaagtctagg 661681 aagggcgagc atcggagcac agcgaatgtt gaattcgtga gcaccgaagc acaggcctga 661741 caacgaatgc gaaggtttgc ctacacgctg aaacttggct tgaataggcc aagtttttct 661801 ttcgcttaaa actagaggtg attatagatg aaaatgaaac ccccagtaga aaaaaatgaa 661861 tactacgatg tgacatttga ggatttgaca catgaaggag cgggcgtcgc aaaggtccaa 661921 ggcttcccga tctttgtgcc gaatgcccta cccgaggaaa aagcccaaat caaagtgaca 661981 cgcgtcaaaa aagggttcgc cttcggccgc ctgattgagc tgaaggaaga aagcccgcat 662041 agaacggacg ccccatgccc gatttacaaa caatgcggag gctgccagct tcagcacatg 662101 acctacgaag gccagctcct gtttaaacag aaacaagtca aagacgtctt agaacgcatc 662161 ggcaagctgg acctttcaaa agtcaccgtg cacccgacac tcggcatgga agacccgtgg 662221 aactacagaa acaaagcaca ggtgccggta ggagaacggg aaggcggact cgtcgcggga 662281 ttctatcagc aaagaagcca tgacatcatc gacatgagcg cctgcctgat ccagcaatcc 662341 aaaaacgacg aagccgttca agctgtcaaa gacatttgcg caaactacgg tgtcaaagcc 662401 tacaacgaag aacgccacaa aggctggctc cgccacatca tggtcagata cggcgttgtt 662461 acgggcgaaa tgatgatcgt cttcatcaca agaacaagcg acttcccgca caaagcgaag 662521 atcatcgaag acatcacagc gcaattcccg cacgtcaaat ccatcgtgca aaacatcaac 662581 ccaaacaaaa caaacgtcat ttttggcaac gaaacaaacg tcatctgggg cgaagaatac 662641 atctacgacc tcatcggaga cgtcaaattc gccatctccg ccagatcgtt ttatcaggtc 662701 aacccagagc aaacaaaagt gctctacgac aaagcgcttg agtacgctga gcttcaaggg 662761 gaagaaaccg tcatcgacgc ttactgcggc atcggaacga tttctctctt cctggcaaag 662821 caggcgaaaa aagtgtacgg tgtagagatt gtgccggaag caattgagga cgcgaagcga 662881 aacgccgaat taaacggcaa cacaaacgca gagtttgctg ttggagaagc ggaaaccgtg 662941 attccaaagt ggtacgaaga aggcattaca gctgatacgc tggtcgtcga cccgccaaga 663001 aaaggctgcg acgaagccct cctgcggaca attgtggaga tgaagccgaa gcgggtagtg 663061 tatgtgtcct gtaatcctgg cacgcttgcg agagatttgc gggtgcttga ggatggcggg 663121 tacgtgacgc gcgaagtgca gcctgtggat atgtttccgc atacgaatca tgtggagtgc 663181 tgtgtgttga taaaattaaa agaataaata gtcaaaaatc tatgctgatg gaactgttgg 663241 ttctctaaaa cgataattga tttcaatggt tccatttgca tgtacttcta tttcatctac 663301 taacaaatga agcatttcgg gggtaagtgt accttccttc atgaatttat ctaagctctt 663361 tttaaaatca attatttctt tttcaatctt ttgaaattct aggtccttag atagttggtg 663421 aagggtagtt tcaaaatttg aaatatcttc attggtgata tttatggcta attggtaatc 663481 ttctttagat ataacaccat tagcaagaga gataactaaa ttggatttat ctctcttttt 663541 atcgtttaat ttttcattaa tttcgattat cttagattcg attttttctt tgtactttaa 663601 cgctttttca cttaattctt taaaataatt ttccttactg aatttcaaat atatcttatt 663661 taggttggtt attactttat cagttaaatc tatttcactt acgtaatgat cactacatgc 663721 ttttaaacca tgtttattat aacttccaca aacataacct tttcgattct ttttaaaatg 663781 cattgacctc ctgcaatctt tgcaaaccgc agtatttgta aagagatgta cttcagcttg 663841 aggtctcctt ctttttctag ttattaaaat ctcttgtaca ataagaaagt cttctaaagg 663901 tatgattggt tcgtggcttt tttcaataat tatttggttt tctaggttaa ctgaccttct 663961 tcttttactg gtaacactcg gtctatattc tctacattgt tgtagtgtcc cagtatagtg 664021 aggattttcg agaatttttc ttattgaaga tccgtgccat ttgtcagtag cgttcttttt 664081 gcgggcaagc tgcgagggac tagtgacccc ttcgttatac aatccccttg ctattgcatc 664141 aaagcctttt ccagcaatat attctgaaaa gattctaata tttactattt tctctgcgtt 664201 tgctgaattt gagagagata tgattgtaga acgaactcaa gaaggtaaaa tgttggccaa 664261 gcagaatccg gatttccgag aaggaagacc caaaaagttc acaaagcagc aaatcaatca 664321 tgcattaaca ttactagaaa atcattcgta taaacaagtt gaagatatga ctgggatatc 664381 agtttctaca cttgtaagag ctaaaaagaa gaaagctgct gaagctataa atggataaat 664441 attgtgaatt aattattcaa tatcttgaga aatttttata aaagtaatca aaagtttaat 664501 gggggaaacg aaatggcgct cattgattta gaagataaaa ttgctgaaat agtgaatcga 664561 gaagatcatt cagatttctt gtatgaatta ctcggtgtat atgatgttcc acgagctaca 664621 attacgcgct tgaaaaaagg aaatcaaaac cttacaaaac gggttggtga agtacactta 664681 aagaataagg tgtggtttaa ggaggctaag aaaggaaagc tctttgacgc ccttattgat 664741 atagaacaac aagttgaata tctttcagct aagccacgat atttattagt tactgactat 664801 gatggagtat tagcgaaaga tacaaaaaca ttagaggctc ttgatgttaa atttgaagaa 664861 cttcctcagt atttcgattt cttccttgct tggaaaggta ttgagaaagt agagtttgaa 664921 aaggaaaacc ccgctgatat taaagcagcc gaacgttttg cacggatata tgatgtactt 664981 cgtaaagaaa acaatattat tgagactaat agagggttag atttatttct tattcgttta 665041 ctgttttgtt ttttcgcaga agatactgac atcttcaaac gaaatagttt tacgaattta 665101 attaagactt tgactgaaga agatggttca aatctaaata aattatttgc tgatttattt 665161 atcgtgttag ataaaaatga acgagacgat gttccatctt atttaaaaga gtttccgtat 665221 gtaaatggcc agttgtttac tgaaccacat acagagttgg aattttctgc caaatccaga 665281 aagttaatta ttgagtgcgg tgaattatta aactgggcta aaatcaatcc tgatatcttt 665341 ggttcaatga ttcaagctgt tgcttctgaa gaaagccgta gttatttagg tatgcactac 665401 acaagtgtcc ccaatataat gaaggttatt aaaccgcttt tcctagataa acttaatcag 665461 tcttttttag atgcatacga tgattataca aaacttgaaa atcttctaac acgaatcggc 665521 aaaattaaat tctttgatcc tgcatgtggt tcagggaact ttttgattat tacctacaaa 665581 gaattacggc gtatggaaat caatattata aaacgacttc aagaactctt gggagagtat 665641 ctttatgtac cttcagtaac tttatctcaa ttttacggaa tagagattga agattttgca 665701 catgacgttg caaaattatc actttggatt gctgaacatc aaatgaatga agaattaaaa 665761 aatgaagttc ataatgcagt acgcccaacg ttaccacttc atacagcagg ggatattcgt 665821 tgtgcaaatg ctattagggt tgagtggact gaggtttgtc ccgcacaagg atctgaagaa 665881 gtatatgttt ttggtaatcc accgtatctt ggttcaaaaa aacaaaacaa agaacataaa 665941 tctgatatgt tatcaatttt tggaaaagtc aagaatggta aaatgcttga ttatatttct 666001 gcttggtttt actttggtgc taaatacgct tcaactacaa atgcaaaagt tgcctttgta 666061 tcaacaaatt cagttactca aggggaacag gtttctatct tatggaatga gttattcaag 666121 tttggaattc aaatcaattt tgcctataaa tcttttaaat gggcgaataa tgctaaaaat 666181 aatgctgcgg taattgttgt gattgtaggt tttggcccgt tagataccaa agtaaacaag 666241 tatttatttg ttgatgaaac gaaaaagcta gtttctaaca ttagtcccta tttaactgat 666301 ggtgaaaata ttcttgtttc ttctaggacg aagccaattt cagacttacc caaactgcat 666361 tttgggaaca tgcctaatga tggcggagga ttactcttta ccattacgga atatacagac 666421 gcaatcaata agtatcctga attagttccc tattttaaaa agtttatagg ttcagtagag 666481 tttattaatg gtggtttacg gtattgttta tggcttaatg aagcaaaata tgaaaaaata 666541 aagtctaatc ctctaataca agaaagaatc tcaatttcaa aaaatcacag ggaaaaatca 666601 acagataaag gaacgaataa acttgcatta actccgtgga agtttagaga tactcatgaa 666661 acaactaatt attccattgt tgttccatct gtgtcttctg aaaatagatt ttatattcca 666721 atgggattag caggtgcaga tacaattttg tcaaatctaa tttatgtaat ttacgatgca 666781 gaaatttacc ttctaggcat tttgatgtca cggatgcata tgacttgggt aaaagctgta 666841 gccggaagat taaaaactga ctataggtac tctgcaggtt tatgttataa cactttccct 666901 attcctgaat tatcaacaag aaggaagaat gaaattgaag aagcaattct tgaaattctt 666961 gatcttcgtg aagagcaggg tggtacatta gcagagcttt ataacccttc aacaatgcca 667021 attgaattaa aagtagcaca tgaaaagttg gatggaattg tagaaagagc gtatcgtcaa 667081 aaacaatttg aatctgatga agaacgctta gaagtattgc ttaaattgta tcaagaaatg 667141 acagaacggt aggtgtaagg tgtatggaaa atataattga aattaattat aaccaaactg 667201 gtaaaagtaa gaaaacaaat gaatacggta tgcgtgaaat gcaggcaaga gcttttgaaa 667261 aacgtaactc acaatatctc ttagttaaag caccgccagc ttctgggaaa tctagagctt 667321 taatgtttat cggtttggat aagctcataa atcaaggttt gaggaaagtg attgttgctg 667381 tacctgaacg ctctataggt tcttcattta aaaatacgga tttaaaaagt tatggtttct 667441 ttgaaaattg gaaagttgat cctagaaata atttaactgt tggcggagat aactctaagg 667501 ttaaatcttt tgttcgtttt atggaatcgg acgatcaggt gttaatatgt acgcactcta 667561 ctttgcgatt tgcgtttgaa aaaattgatg ataaagcatt tgataattgt ttacttgcaa 667621 tagatgaatt tcaccatgta tcggcagatg tcaattctcg attaggtgaa ttgttaagaa 667681 gtattattca taattcatca gcacatattg tagcgatgac tgggtcgtat ttccgtggag 667741 attctgtacc aattttatta ccagaagatg aggaattatt tgacaaggta acttattcct 667801 attatgaaca acttgatgga tatgaatatc taaagggatt tggtatagga tatcacttct 667861 atcaaggcca gtacacatca gctattaatg aagtattgga tacaaataag aaaacaatcg 667921 ttcatattcc aaatgtaaac tcaggggaat cgacaaagga taagtacgat gaagttggta 667981 agatacttga tatgattggt gaagttgaat atcaagatga tgatactgga attatttatg 668041 ttaagcgaca ttctgacggt aaaacattga aaattgcaga tttagtagat gaccaagttg 668101 gaagagaaaa tgtcgttgcg tatttgcgta atattgaagc cctagacgat ttagatataa 668161 ttattgctct tggtatggcg aaagagggct ttgactggcc gttttgtgaa catactttga 668221 cagttggtta tcgtggctca cttacagaaa tagtacaaat aattgggcgc tgtacacgtg 668281 atagttacaa taaaacctat gctcaattta ccaacctaat cgcaatgcct gatgcaaagg 668341 atgaagtagt gacttataca gtgaatacaa tgcttaaagc tatttctgcc tcacttttga 668401 tggagcaggt ccttacacct gactttaaat ttaaacgtag aagaaatgaa agtgaaaaat 668461 cttctactac aggagaatta ttcgttaagg gattgaaaga accatcaaca gaaaatgtca 668521 aaaagattat tgaaaatgat attaatgatt taaaagcaaa aatcatgcaa gattcacaag 668581 tccaaaaaac atttagtgga gaagtagatc ccaaagtatt gaacaaagtg ttgattccga 668641 aagttattca aaaagtatat ccaaatttat cagatgagga aattgaggaa gttagacagc 668701 acgttgttct agatacagtt atgaaaggtg ctaagtctga agttgtagga agtaaagaat 668761 ttataagaat ggcagataag tttataaaca ttgaggattt agatatcaat ctgattgatt 668821 ccatcaatcc gttccaaaaa gcatttgagg ttctatcgaa agaattgaac tcaccagtgc 668881 taaaactgat tcaggaaact attgatgcaa aacgtattaa ttttgatgaa gatgaactag 668941 tattcatatg gccaaaggtt taggaatttt atcgttcaac tggtagaaga cctgattcaa 669001 aatctgaaga cccacttgaa aggcgtatgg gtgaagctgt attatacatg caagagctta 669061 ggaggaaacg tgaaaatggc aagtaataga taccattcta ttaatgaaat catggaaagt 669121 cagctgtttt accaaatcac aacaccacct aagaaaacac aaaaagccca gtatgatcct 669181 gaagttgaaa agtttttgga gattattgaa ttcgtcaaag aaaatgggcg agaaccccaa 669241 aaagtcccta ctgatttaac tgaaagaagt ttagcaagtc gattaattgg gattcggaaa 669301 gatcctgatc gtatggaata tttgaaagag tatgatgaaa ttggattact tgaagtaaga 669361 tcgaaggaac taacaattcc taaaatttct tcaattgatg atattctaaa aagtggctta 669421 tctgcattat taggtgataa tttaaataat gatataacta ggtcaatttt tgatacaagt 669481 tcacttcaaa aggttacgac aatgcctgaa tacgttgcaa agcgtaaaaa aataaaagat 669541 tttggaaagt ttgaagagct attcaagaag tgccacaagg aaattacaga gggtaaacga 669601 aaaattttaa ctttcaaaaa tgaacaagac atacagtcaa atagttttta tatattaaaa 669661 ggagttcttc tttatgttga agatgtggga gaacgtaaaa aagcaaaggg aaaaaccaat 669721 gctagacttc gatgtatatt tgaaaatgga acggaatcag atatgttact acgttcctta 669781 tcagcggagt tatataaaca tggtagacgt gtgaccgaca atgaagatac attgttggat 669841 aatgttagag aagatgatgt ttcgactggc tttatttacg tactaaaatc tttgagtaca 669901 gatccgcaaa ttagttccat taagaattta tataagatcg gttttacaac tggttcagta 669961 gaaaatagaa tcaggaatgc agaaaatcaa tcaacttatc tttatgctcc agtagaaatt 670021 gtaaccacat atcaagtgtt caatatgaat gctagcaaat ttgagacggc aatccatcat 670081 gcgctagcaa ataataattt ggatgtttct attttggggg caaatggaaa gatgttagtt 670141 cctaaagagt ggttcgttgt cacacttgaa gatttacaag ctgtaataga tgagattgtg 670201 atgatggttc atctttatga ctaaattagt atattaggat tttagtatta ataataattt 670261 tatagtagac tatgaaaaaa tttgatgcca taacaataac ttgttccgct ttggagtttg 670321 tcacaattgt agaattatgt gttgcgagta ttaataggaa ggggttgagc gaccgcaaaa 670381 aaaattttcg gtgctgtccg caaaagggag tttgggtgtt ttgcgttata tttggttgtg 670441 tgaaggttag cggaaactca attcgtgaag ttaggattgc ggttattacg actgagtagt 670501 ttcgtcatac tcttttagca gtttttctgt cttatgcatt tctttgagca tcggattcat 670561 gtagtcgtta gctgattcta gatatgctct cgtcagagtg tctagtttat ttctaacttt 670621 agagaggtct tcttcgaatt ttccatccga tgattgaagg ataaattctt ttgcctcttc 670681 atatcttttt aatatgtttt tcaccattgg agttggattc ttttgattta ttgtttttat 670741 tacagtgatt gttaaattta tttgttttat taattctttt cttactgtca aggtgatgct 670801 ccttttaaat ctctattcta tttgagagtt gctatatctg tttaatggtt tgatagacta 670861 ctcatcttta taatttagag caatttttac aacttgttcc gctgtgtaat cttcattgct 670921 ccagaaaatt aaatcacttg gtgccggata aggaacattt ttctctaata aatcgagata 670981 ttcactgact ttctcatcat ctaatgttgg gttcattaat tcctttacaa gaaagatcaa 671041 ctcttctttt gtcagtttat ccattgtttg ccctccaata gattgtatct ccattgattt 671101 tacaaatgac tttatttctt ctgataatgt tataggttgt ttgcataatg atagataatt 671161 gtcttgagaa aagttagtct cattatagag tttattaatt gtatttataa caatatattc 671221 atatggaaaa cctctaaaat atctttattt tagattggtt tataaaaaat agctcagcag 671281 agtagggctg agccattttt taattataga ccgaggtaac taattacaaa ttctttatca 671341 tcctcatctt caggcaaaat accaaggttt ttatattccc atattgcgat tctttcatat 671401 ccatctaatt ctgaggctaa aatatcatca taattataat ctaattggaa ttctccgcta 671461 cgatccaatg ttagtgtaag gttagtccaa acatcatcgt tattatttct gtgttcagtt 671521 cttaattctt caaaaagttc tcttagttct cttaacaacg tcttgaaaat atccttgctt 671581 acgttgtaat ggctaggtat atcttgtgaa taaataattt gattattttc tggtgttctg 671641 aaatgaaaaa gaaccattgt ggaatcatct aatacttctg cataaagata tatctttgtc 671701 cattcaccag gtatgatgtc attgagtttt tctccaataa gttgatacaa atcttgcatc 671761 ttcctagttt ccattcttct aacccccagg ctgattttta atagagacgc ttatttcttt 671821 tctgctccca attttgtagg ttacatcgaa atatgatggt ctaagtgaat ccccagaata 671881 gactggttct atttgaactg ctactttttt aggtggtttt ttgcttaggg cttttgccca 671941 ctcctgctcc atctcatacc atttcccacc gctcctatta atctgagaat tcatcggcac 672001 gatattgtca aactggcctg agcctttgaa ttgggtggcg attaaatggc cgccgtcatc 672061 gtcaggcttt cggtcctggg gctttccagc attcgtttgt gcatattggt ttcgtttcgc 672121 ttctcccagc tgcaagtctg ctttgacact tgtaattcta ccatagttgt cagtcgtgta 672181 cgtgtagcct tcttttgttt tgtagatgat attaggcttc agcactttct ttctgctcca 672241 tcttgcgaaa tgctcgccgt atttgacggt taccggcggt acatgtggcg ctggagttcg 672301 tcttccgctt gatgacgttc cgtatggttt cggcaggatg accttggcga atttttgcag 672361 tccttcttta agcgtgaccc cgttgactgc gttgtaagga acgcctgccg gcactaaatc 672421 atgacgggga tgatacggga gaatatccgc aagtgtgaga tctccgattt gatttaactt 672481 ggttttgacg tgtttttttg atacttcaat gcctgtgttt actttttgtt tgatgtgatc 672541 aacggtttgt tttgagactg ttatggcttt ttgggctgtt gctgatttgc ttgctgctgt 672601 tttgactttg gtcgtcactt tggcggctgt gccagttttt gagacggctc ctacgccttt 672661 tgtgccgaca attgatgtga caacagtgcc aaccgcatat gacacccatc ttgctcttga 672721 gtaggtgtca ccattcacca tgtctttttg atacgattct tcgattgccg ctgaaatggc 672781 ttcatacgtt ttgatcgggt gagccatcgc tccggtaatc gcttcaacgg ttcctcccgg 672841 atctgtgacc atatcccaca ggcctacgac cgcgtctttc ccggaatcat aaaggccgac 672901 ggcaacccct ttgaagcctg cttcaagctc acgcgtgttt tcaatttggg tgaagtatct 672961 ctgttgttca gctgtcagat tttcatagcc gatcgttttt gccatttcgt agaattcatc 673021 ggcatctgca taatcgtagt ttttcagtct ttctttcagt ttctcaatct cgcgttcctt 673081 cgcttcctct ttcttaatct tcaagtaagc ctcagtccgc ttttcaatgt cgcctttttt 673141 cttatgtatg tcactctcac ggtacgcctt ggcgttgtag tggatgggtg tggcgttttt 673201 gcctttaccc gttgcttctt ggagcttttg gaagtcggat ttgatgaatt gttcgtttgg 673261 ttcagacagg gcgtattctg ttttcaggtc ttcgtccaag gcgtccaatt tttccagtgt 673321 ttttttgcgt ttgtcgttgg catcggccag ctcgtctttg aaggtttctg ttgaaaacag 673381 gtcgagcggg aggatgtcgt cgatatcgtt taggatgtct ttcatcgctt ttttctgttc 673441 ggacatgatg gatttagatt ttttattggc atttgccagt tcgtgctcca ggaaggattc 673501 ttcgatgtat gcgtctgaga ggcctttgtc ttcggcggct ccggcgatgc tgttgaaaaa 673561 tgcgattttc atgtcgatgt agtcgatcca ctggtcggcg acgccgacgt ggtcgtgata 673621 gaatgccttg atgttgctgg cgccttttcc tgagaattca ctgtcactga gatcagcgac 673681 tccttttaac gcttttctca agttgaccat ttgcgttctt agttctttgt actcttttgc 673741 acggtctgtc gcttccgaaa gcagtgtttt cgcttcaaat actttcatga ccatttccct 673801 tcttttgttc gctcaatatc aaaattttac cacgggtcgg gataaggtgg gggtgagaac 673861 gtgttttggt ggaaaaatga gtcatttggc atgtgtcttt attcgtggag ggattggagg 673921 aaacatggtc gaaatgatat tgattgctac acattttttg gaagtttgta ttctatattg 673981 ttttttaagg agcatgttga tgacgaaaaa acggattaca tttggtttat tagttttaat 674041 ggtatgtgtc atcctgtttg ttctgtatgt tcagttacgc aataaagata gtattcctgt 674101 ccaatcttcc gccattcacc ccgaagaaga ccgcatcttt tttatttact ccaatccttt 674161 cataaaagaa agcgtgctgc tttcaacctc tacaggcgaa cggtttaaca ggcgtacgtt 674221 taaggtggcg gatgtgcctt atattcaaac gaaatcttat gcatcaacag accttgtatt 674281 attggcggaa cacgagcctt tttactacac gctggagaag gatgtgatca aagagcatcc 674341 gctgtcagat ccatttgcgt tttggtatga ggggaaggat gtcactattg aggcctataa 674401 tgttgatacg acgggaaatg agatccacat aaacgacaga aaaacgaaaa aggaatatac 674461 ccttaccttg cctccgcttg tcacaatggg ggccagtgat gagaacttta tttatatcat 674521 tcaaagcatg tctatttacg tgattgacag aaaaacagag gaaatgattg agaccctgag 674581 cttagcctca tacgctgatc aattcgcaga ctcggaggaa tttatcgtcg cgagctcgga 674641 tcataaattg actgtgattg aaaaagggac atggaagacg acatatattg cgtatcctga 674701 agatcttgaa tatgcagata ctgtgtacta tgacaaagaa agcggcagtt tttacgtggc 674761 gtacgaggac aaagagggtg gagcgaactt gctggaatat ggggaggatt tttctattca 674821 cacatacagc ttgaaattcc cttatatgga ggcgaagttt aaggggaatc tattgtatat 674881 agttgcccag gaagagcata aaaagggcat cggcggatac gtgggtgtgt ttgatatcca 674941 ttctaaggag atgctttatc agtttgattt gcctgaggaa caggtgaagg ttcaggattt 675001 tgttgtggtt gacaataagt gaatactata tgaaatagaa tgacaaagac ccttgcataa 675061 agggttcttt tttatgaaaa aaacaaattg acaggatgaa aaaacaattt cttccttcta 675121 tattgttttc aaaatttggg attgatagaa tatgacatat ctcatagaga aggagggaag 675181 ccgttgagtc aagccatacc gtcttcgcgt gttggtgtta agattaatga atggtataaa 675241 atgattcgcc agttcagtgt tccggatgct gagattctga aagcggaggt tgagcaggac 675301 attcagcaga tggaagaaga tcaggattta ctgatctatt attctctgat gtgttttcgg 675361 caccagctga tgcttgatta tttggagccg ggaaaaacat acgggaatcg ccctacagtg 675421 acagagcttc ttgaaacgat cgagacccct cagaaaaaac tcacaggtct tttgaaatac 675481 tactctttgt ttttccgcgg catgtatgaa tttgaccaaa aagaatatgt ggaagcgatc 675541 ggatattatc gcgaggcgga gaaagaactg ccgtttgtgt cagatgatat tgagaaagcg 675601 gaattccatt ttaaagtggc agaagcgtat tatcacatga agcaaaccca tgtgtcgatg 675661 tatcatattc ttcaagcctt ggacatttat caaaaccatc ctctatacag cattagaacg 675721 atacaaagct tgtttgtgat cgccggcaac tatgatgatt tcaaacatta tgataaagcg 675781 ctcccgcatt tagaggcggc gctggaattg gcaatggaca ttcaaaatga caggtttatc 675841 gccatttctc tattgaacat tgcaaacagc tatgacagat caggagacga tcagatggct 675901 gtagaacatt tccaaaaagc ggcgaaagta agcagagaga aagtgcctga tctgcttccg 675961 aaagtcttgt ttggattaag ctggacatta tgtaaagcgg gccaaacaca gaaggcgttt 676021 cagttcatag aggaaggatt agaccatatc acagcacgtt ctcacaaatt ttataaagaa 676081 ttgtttctgt tcttgcaggc cgtgtacaag gagactgttg atgaacgaaa aattcatgat 676141 cttttaagct atttcgaaaa aaagaacctg cacgcttaca ttgaagcatg tgcccggagt 676201 gctgccgctg tttttgaaag cagctgtcac tttgaacaag cagctgcgtt ttatcggaaa 676261 gtgctgaaag cccaagaaga tattctaaaa ggagagtgtt tatatgccta ttaagaaaaa 676321 agtgatgatg tgtctggctg ttactctagt tttcggaagc atgtcgtttc caaccctgac 676381 aaactccggt ggatttaagg aatcgacaga tcgaaatacg acgtatatcg atcattcccc 676441 ttacaaactt agtgatcaga agaaagccct tagctagggc tttttcttgc tttacggaag 676501 acgttccatt ttccacatcg cggcattcct tctatttcta acgcaagaca ctcgaaacaa 676561 ccaaaccatt tgaggtataa tggataaagt gaataacagt atttagattg atatatatga 676621 aagagagtgg aacatcatgg gccgtaagtg gaacaatatt aaagagaaga aggcgtctaa 676681 ggacgcaaat acgagtcgga tttatgcgaa gtttggccgt gagatttatg tggcggcgaa 676741 acagggcgag cctgatccgg aatccaacca ggcgctgaag gttgtgcttg aacgtgcgaa 676801 gacttacagc gtgccgaaaa acatcattga acgtgcgatc gagaaggcga agggcggagc 676861 ggaagagaat tacgatgagc ttcgttatga gggcttcggg ccgaacggat caatgattat 676921 cgttgatgcg ctgacgaata atgtaaaccg tacggcgccg gaagtgcgtg cggcgttcgg 676981 gaaaaacggc ggaaacatgg gtgtgagcgg atctgttgct tacatgtttg acgcgacggc 677041 tgtaatcggt gtggaaggca aaacggctga cgaagcgctt gaaatcctga tggaagcgga 677101 tgttgatgta cgtgacattt tagaagagga tgacagcgcg atcgtgtatg ccgagcctga 677161 tcaattccat gcggtgcaag aggcgtttaa aaacgcgggt gtcgaggaat ttacagtagc 677221 ggagctgaca atgcttgcgc aaagtgaagt aacgcttccg gatgatgcaa aggaacagtt 677281 tgaaaaattg attgatgcat tagaagattt ggaagatgtt cagcaggtat atcataacgt 677341 tgatttaggt gagtaaggag tgagcaggct gttatggcct gctttttttg tcccggaaat 677401 tgttttagct gtatgtaggc ggccgcctat acgatctata agatattctc atactctgga 677461 ctgtaaccta tgtgaaggag agagtaaata tgactgatac aagacatatg tatggcggac 677521 ctggttttgg tcattatcag ggctttggta ttggccaccc gggctatggc atgcaaagca 677581 caggctatcc gggctatggc atgtatggag gccacccggg ctatggcatg caaggctacc 677641 cagatcacgg catacatgga ggagtcggcg gctatccggg atatggtggg tacggcggtt 677701 acccaagcgg cggctatgga ggctctccgg gaactggaag ctatccgagc atgcaccatg 677761 aaaatgatgg ccatcaccac tattatcacc atcatcatga tggaaaagat aatcttcatc 677821 accatcatca ccatgttgga aaggataatc atcaccacca tcatgatggt cattatggcc 677881 accatcatca ccatatgggc cactggggaa aagacggtta taaataaaga agatgatgat 677941 aaaaagagga cactcttgca gatcaagagt gtttttttag cttttttctt gactgttcag 678001 tctggaaaat ggtaacattt gtttcaggag gtgatcattt tttggggagg aataaagaat 678061 ttgatacggc gcttgttctt cacagggcga tagaggtttt tggagagtat ggctacgaag 678121 gaacgtctct tcaggatctg ctctctcatt taggcattgc gcgccaaagt ttgtatgata 678181 cgtatggaac gaagcgtgat ttgtttttgt ccgctgtgaa atcgtatctt gaagggaaaa 678241 acgctgccgt tatggaaagg cttgaagcgc caggatctgt aaaggaagcc attcgtgata 678301 tttttcagga gggtgtcaat gccctgaggg atccggaacg ggcgaaggcg tgctacatta 678361 ttaacagcgc gattgaacag atcccgcatg accctgagct tgcccggtat tttgaaagac 678421 aatccaagca gcttgaggac gctttttatc acgggctttt aagagcgaag gatcaaggag 678481 aattgaatgg cgaagatact gatatatctg cgcttgctcg gtacctgaat cagagcaggc 678541 tgtcactgac atttattgca aaagtgacgg cagatatgga tcggcttcag gaccatgttg 678601 acgtgagttt atcagtgctt gattaacatg tggtaaagga ttctttgccc atgtatgtac 678661 tttttggact gaatagtcta gaaataaaaa tgaggtgatg atgaatgttg atgaatgagt 678721 ttgaaaaagc atgtgaaaca ttgagaaagt ttatggctta tatgcttgag aaggacatga 678781 agagctggac ggagctttgg gatgagaatg ctgtatttga gtttccttat gcgccggagg 678841 gatcaccaaa aagaatagaa ggaaaagcgg ccatttacga ttatattaaa gattatccta 678901 agcagattca tctttcttca tttaccgctc cgacagtgta ccgttcagca gactcgaata 678961 cggtgattgc ggagtttcaa tgtgacggcc atgtgattga gactggactg ccttatcgcc 679021 aaagctatat cagtgtcatc gaaacgagag acggccgcat tgtgcgttat agggattatt 679081 ggaatccgct tgttgtaaaa gaggcctttg gaggatcatt tttgcaaaca gaggagagtg 679141 ggaaatgatg aaacagaatc cgattttaat cacgggcggg accggcacag tcggcagccg 679201 aatcgccagc cgtttaataa agctgggata cagagtgcgt attgcaagcc ggaaaaaggg 679261 cgcgcttgct gatgctgagt atgtgtattt taattggaag tacgcctcca gttttacgcc 679321 tgctctggaa caggtaaaac agatctatct tgttgctccg gtcggtgtat ttgatccggc 679381 tccctatgtg cttccctttt taaaggaagc aaagcgtctc ggcgcaaagc gggtagtgat 679441 gcaaagtgcg tctgttgtct ccgagaacgg tcccgtgttt ggcgcgcttc accaggcagt 679501 gcgcgagttt ccagaatgga cggtgctgcg gccctcatac tttatgcaaa atttcatcaa 679561 tgtccagcac cgcatgtcta ttcaaacgga ggggcgcatc acaacggctt cgggtgaagg 679621 aaaacttggg tttattgacg ctgatgacat cgcagaaaca gccgtcaggg ctttgattga 679681 tgatgttcct catcaaacac atcatattct gacaggtccc gaggcgctga gctatgccga 679741 agcggcggag atcattggag ctgcggcggg acgccgggtg gagcatgtca gcatttctcg 679801 ttccgagctg cagcataaaa tggaggcagg aggtttgccc gcggattatg cccattttat 679861 ggcgaagctt gatgaggcaa ttagccatgg tgcggaacat cgggtaacgg atacagtgaa 679921 gcgtgtgacg ggaaaagaac ctcgttcgct gtcagagttt gcggctgctc atgctgcata 679981 ttggacctca ttttggactg aatagtctag aaagaccttc ggcgcttccg aaggtcttct 680041 tattgaaaaa gctaagtcgt gttttagtca taatcatgcc tcctgcctca tacctattaa 680101 ggtcattgtt tttgagaaag gaggagccgg aatgaaggat atgcagccgt ttacgcctgt 680161 caaatcatat acgccctttc acagccgttt tgatccctgt ccgcccatag ggaagaaata 680221 ttacagaacg ccccctaacc tttatatgac ctttcagcct gagcacatgg agcagttttc 680281 gccgatggag gctttgagga aaggcaccct ttggaaggat ctctatgatt tttatgaaaa 680341 cccttatcga gggggagacg cacatggcaa aaaaggttga cgccgaatat tatcgtcagc 680401 tagagcaaat acaggctgct gattttgtgc ttgttgagct gagtctttat ttaaatacac 680461 atcctcatga tgaagatgcg ttgaagcaat tcaatcaata ttccggctat tcaaggcact 680521 taaaaagaca gttcgaatcc tcttacggac cgcttctgca gttcggcaac agccccgcgg 680581 gcaaggattg ggattgggga aaagggccat ggccgtggca agtataagga ggaatgcctg 680641 aatgtgggtg tatgaaaaga agctgcaata ccctgtcaag gtcagtacgt gcaacccgac 680701 gctggcgaag tatttgattg agcagtatgg cggagcggac ggcgagctgg ccgcggctct 680761 ccggtatttg aaccagcgtt atacgattcc tgataaggtc atcggccttt taacagatat 680821 cggcacggag gagtttgccc atttggaaat gattgcgacc atggtctata agttaacgaa 680881 agacgccaca ccggagcagc tgcgtgaagc tgggcttggc gatcattacg tcaatcacga 680941 cagcgcgctt ttttatcata atgcggcggg cgtgccgttt accgcgagct atatccaagc 681001 gaagggcgat ccgattgccg atttatacga agatattgcc gcagaagaaa aggcgcgggc 681061 gacgtatcaa tggctgattg atatttcgga tgatcctgat ttaaacgatt ccctgcgttt 681121 tttgcgtgag cgtgaaatcg tacactctat gcgcttcaga gaagcggttg aaattttaaa 681181 agaagaacgg gataaaaaga agattttcta ataggcagat tggcctctct ttcatacacc 681241 cttttacata cagagaaaat ggtctgtttt tgcagtttgg tctgcattat aatcaaggtg 681301 tgtgtgcaag cttacttttt gattgggagg cctttatgac agcttttaag attgagaacg 681361 aaacgattgc agatggattt tacgcgtgtc cggccgtcta tgaggatgca gaatcgatta 681421 ccgggttgct cgtccgaaca gctgaatggc tccgggatcg gggttctaac caatggagcg 681481 gacttctcaa agggcaagat atacatgata tcacggggtc aattgaaaag ggacatgtgt 681541 ttgtgtttaa aaaagatgaa gagcttgcgg ctgtcgtgat gctgctgcct gcaccgagcg 681601 agtgggaccg gacgctttgg ggagacgatg ggcatgagga gtccatttat ttacaccgcc 681661 tcgcagtaag ccgccggttt gcgggacagg ggcttggagc ccgcgtcctt cagtgggcgg 681721 agacgggcat acactttccg gaaaaaacgc ggatccggct tgactgtgtc gctgatagtg 681781 acgccctgca ttccttttat cggcgtatgg gatatgaatt catgggtgct gatgcgtccg 681841 gatatcattt gtttgagaaa gagattacgg cagaataagc gtcctttgca gggggctttt 681901 ttgtcttttt ctaaaaggga ggcaggcgat gtgtggtcaa tattatttgt gacagggatt 681961 gtgacggctt gtctgtttgc tggcgtatcc gtattgatgc ggatgagatt tcctgacaaa 682021 agtcggccgg aatggatgtt ggccgggctg atcgtccttg gtgtgtttgc gatctggtac 682081 agcctcgtgt atgtacgcgg ctgggaaggg gctgcgctcg gaatgcttgg attcaatgtc 682141 attttcggag ccattgccgg atatttgatc gataaggcca tccggcgtta caggaaaaga 682201 taaggctgct gccgtctctc aacaggtcga aattttcaca gaccggcagg aattttcttt 682261 cgaaaggaga aatacatatt actttaaaat gaaagcgttt tccaaagcag gaaggtgatg 682321 ttgatgatac acagtgtggc aaatgggctg aatcattttt gtacgtgggt gatgagactg 682381 gcctatttga atgtgctttg gattttgttt tctcttgcag gcctggttgt atttgggctg 682441 atgcccgcta ctgccgcgat gtttacagtg gcgagagaat gggcgaaggg gaatacagat 682501 gccccggtgt tttctgtctt ttttcggacg tttaaaaagg aatggcgggc atcacagatc 682561 ctcgggctta tcgttgtgac ggctgccctg tttctgtttg cggatatgcg gatagcggct 682621 cagatggacc agcctgtgct cgtcaatgta ttcgtgagca ttagtttgat tttcgcgttt 682681 gttgtgctgt atgtgttccc ggtattttct cattttgacg taaaaatcag agaggtgctg 682741 agcatcagct ttttcattgc cttcagtcgt ccggcggtga cgcttttgat ggcagcgggc 682801 gctgtcggtg tgctttgtct cgttctgttt catgtcacgt ttctattgtt tttcagcggg 682861 agtttactca gcctgatctt aacgaagctg tcctttaaag cgtttcggtc aatggatcag 682921 cggcaggaga aagaaaaggc ggcatgaaga aaagagttgc tggctggtac aggcggatga 682981 agattaagga taagctgttt gtgtttctat cgttgattat ggccgtatcc tttctgtttg 683041 tatacagcgg ggtccagtat gcctttcatg tgtatgatga gcagatttac cgcaagtcct 683101 cggaggtgct tcggatgtct tctgaaagga tcgaagacga gctgaagaag atagaggatg 683161 tgtcatatga aatcattaca gacgaacaga ttcagcgcat cctgagcatg caaaatcggg 683221 atgatacgta tgatcaatat caaatgaagc aggagctgtg ggatcagctt gcgggatatg 683281 ccagcgatga aaagtacatc gattccattc atgtgattga tgcccgcggc tcagagtatt 683341 cagccggaag cagttcttca gatcttttgc agcaggagca ggaagaggta tttaagcgag 683401 cgaaagcgaa aagtggaaga aatctttgga tgacgctcgg cgggtcagac cccgtcctga 683461 tttcagcacg gcagatcagg tcctatcacc agctgagtct gaacggcttg ggcatggtac 683521 tgatccaggt caatgtaaaa cagatgattc gtgatgtgcc gaaggattgg ggcgattcag 683581 tcggagacat tatgattgct gaccaaggcg gtaatttggt gtatacggca catgcatcag 683641 cgcatgttcc tgaggcagca aaagagacgt tgaagcaccc cggttatgac ttgataaaaa 683701 agaatggcaa acgttacttt atttcttatc ttcaatcatc ctaccaaaat tggagctact 683761 ataacgttat cccctttgat cagatgttcg caaaaatttc ctttatgaaa acagtgatcg 683821 gcacatgctt tcttctcttt ttctgtgtgg ttttgctttt cggaaggaaa atcgccaaca 683881 gcatcacgga gccgattgaa cagcttgtga ccgcgatgaa atcggtacag cacagcggca 683941 ttgaagcagg tgtgtcgctt tctctgccgg aacatacaca ggatgaggcc ggcatgctga 684001 accgccattt tactgtcatg atgaaacgga ttaatgagct gatggaagaa aatgtggaaa 684061 aacagctcat cattaaagaa accgaattga aagcactgca agcccagatc aatccgcatt 684121 ttttatataa cacgctcgag tccatcaatt ggctggccaa ggcgaatcag caaaagcaaa 684181 tctcaaaaat ggtggaatcg ctcggttttc ttctgcgaaa cagcatacat atgaagaagg 684241 atatcgtgac cattcaggag gaggcggaca ttgtacgtca ctatatgacc attcagcgat 684301 ttcgatttga agagcgcctg aaattcacgt tggatattga cgatgaggtg aagcattgcc 684361 tcattccgaa actgacgctc cagccgcttg cggaaaatgc gattcaatac gcgcttgaac 684421 cctttacaag gccatgcgcc atccggattc aggcgaaaaa ggcgaagggc tgtgtctgta 684481 ttacggtcga agataacggc cctggcatgg atggacggat tcttgaatca acgggtggaa 684541 gaggaatcgg actttggaat attcgcgagc gcatcagcct gacattcgga gagccatacg 684601 gattgcggat tcatagtgag catgaaaagg ggacgaggat tgtgatcaca ataccgtgcc 684661 gaaatgaggt ggtgtgatgt ataaaatact gctggctgat gatgagagga ttatccttga 684721 tggaatggcg ggaatcattg agtgggagtc gcttggcgcc tcattgatcg gaaaagcgca 684781 gaacggacat gaagcatatg aaaagattgt acataagcag ccgcatatcg tcatcacaga 684841 cgtcaaaatg cccggcatgg acgggcttga gctgatcaaa aaggtgtcag ccgtcagccc 684901 gtcggtgcaa tttatcgtcc tgtccgggtt tggagagttt gagtacgcaa aggaagccat 684961 gaaatatggg gtgaagcatt atttgctgaa accctgcaat gaacagcaga ttatcagctc 685021 gctggaggaa atcattgctg agctgaagcg gcaagatgtg cacaaaaaga aaacagccca 685081 tctgaaacac gagctggacc atatccgttc ctttgcagcc gatcaatact tggaaggctt 685141 gatcgccggt gtggcccagc tttctccgcc gccttcactt gccggaaaaa agatccgcct 685201 cttgatctta aaaggggaac aatctattga tgctgcagcc agagaggcac tcggatcggc 685261 actgacagcg gtttgcagca gcggtgaatg gaccgtgctc gccgtagagg agaacgccgc 685321 tgaaaaggtg gcggaggttt ttgcggaccg caagatggcc atcagtcagg cgggagaact 685381 ccggcacgcg gggcagctgt ttcgtgacac agctgaagcg tctggtgacc tgcatgggag 685441 cgcagtgatt tcaaaaatga tcaggcttat tgccgacgag ctcggaaatc cgaatctgtc 685501 cttaaaatgg gcggcgaagg atatgctgtt tatgaatcct gattatctcg ggaagttatt 685561 taagcaggaa acaggcgaga aattttccca atatgttaca cgggtgcgtc ttgagcatgc 685621 gatgaagcag atgaaaataa ggagggacgt gagcgtttca gaaattgctg aagaaatcgg 685681 gtttggcgat aatccgaagt atttcagtct tgtttttaaa aaatataccg gtctgacacc 685741 gtcagaattc agaagaaaac agggaggcgc ttccgcagga tagccatctc tgtttttttg 685801 actttcgcca ctgttttttg agtgtttcgc cctatccgaa cgctttaaaa taaaatgtaa 685861 gcacttacat taaagggggg attggtttga agaagatttg ttacgtgctg ttatcccttg 685921 tctgcgtctt tttgttcagc ggatgttcag cgggtgaaga ggcctcggga aaaaaagaag 685981 atgttacact cagaatcgcg tggtggggcg ggcagccaag gcatgattat acaactaagg 686041 taattgaact atacgagaaa aagaatccgc acgtccatat tgaagcggaa tttgcgaact 686101 gggatgacta ctggaaaaag cttgcgccca tgtctgccgc cggccagctt cctgatgtca 686161 ttcaaatgga taccgcttac ttagcccaat acggaaagaa gaaccagctg gaagatttaa 686221 cgccgtatac aaaggatgga acgattgacg tcagttcaat cgacgagaat atgctgtcgg 686281 gcggaaaaat cgacaataag ctttatggat ttacgctagg tgtcaacgtg ctgtctgtga 686341 ttgccaatga agatttgctg aaaaaagccg gtgtgtctat caatcaggaa aactggacgt 686401 gggaggatta cgagaagctg gcgtatgatc ttcaggaaaa agccggtgtc tacggttcca 686461 acggaatgca tccgcctgat attttcttcc cttattattt gcgcacaaag ggtgagcgct 686521 tttataaaga agacggcact ggcctcgcgt atcaagatga tcagctgttt gtcgattact 686581 ttgaacggca gctgaggcta gtgaaagcga aaacgtcccc aacacctgat gaaagcgcac 686641 agattaaagg gatggaagac gattttatcg tcaaaggcaa atcagcgatt acatggaact 686701 actccaatca atatttgggc tttgcccggc tgacagactc gccgctgtct ctctatctgc 686761 cgccggagca aatgcaggaa aaggcgctga cactgaagcc cagtatgctg ttttccattc 686821 cgaaaagctc tgagcataaa aaagaggcag cgaaatttat taatttcttc gtgaataatg 686881 aggaagcgaa ccagctgatt aaaggcgagc gaggcgttcc agtctccgac aaggtggcgg 686941 atgcgattaa accgaagctg aatgaggaag aaaccaacat cgtggagtat gtagaaaccg 687001 cgtcaaaaaa catcagcaaa gccgatccgc cagagcctgt gggaagcgcg gaggtcatca 687061 agctgctgaa agatacgtca gatcagattc tgtatcagaa ggtatcgccg gaaaaagccg 687121 ccaaaacgtt ccggaaaaag gccaatgaga tattagagag gaataattga cgggaaatgg 687181 ggctgacgca atgaaaaaaa gccggagtat aagaaaagac aatctggcgg gatatgcttt 687241 tatttctccg tttatcatcg ggttcctatg ctttacggtg attccgatgg gggcgtccct 687301 gtttctgtcc ttcacgagct atgacttgtt tacggcgccg aaatggatcg ggctcgacaa 687361 ctttaaggaa atgtttacgg gtgacgaaaa gtattggcag tctctgaagg tgacgtttac 687421 gtatgtgctt gccggggttc cgctccgcct cggcttcgcg ctttttatcg ctgtcatttt 687481 aaacaatgca gcaaaaggaa cggccattta cagaacgctc ttttatctgc cttcgatcat 687541 cggcgggagc gtcgccgtgg cgattatgtg gcgcaatatt tttggcaatg acggggtcat 687601 caatgcgctg ctgttttttg tcgggattga tcaaaaaatt ctttggtacc agaatccgac 687661 aagtgcgctg tggacattga ttctgctgtc cgtctggcag ttcgggtcgt caatgctgat 687721 ttttttggcc gggctgaaaa acattccgtc ttcgtatttg gaagcggcaa gtgtggatgg 687781 ggcaaatcgg gtgcagcgtt tcttcaagat cacgcttccg atccttacac cgattatttt 687841 ctttaaccta gtgatgcaga cgatttctgc ttttatgaca tttacacctg cctatatcat 687901 ttcgaagggc gagggcgggc cgcttgacgg gacacttctc tattcgctct atttgttcca 687961 gcgtgcgttt aactattttc aaatgggcta cgcatcggcg atggcgtggg tcatgcttgt 688021 cattgtcggg ctgattacgc tcatattgtt taaaacatcg tcatattggg ttcattacga 688081 gtcaaaggag gaatgacgga tggagccggt caaccagcct gtcagagaag ccccggtttt 688141 tgagagaaaa aaagccgggc gcgtcagtcc caaacgcata ctgttccatg tttttacggc 688201 aacgctggcg gtgttgctgc tgtacccggt tatttggctg tttgtcagct cgtttaaaga 688261 aagcgccagt atttttacaa cctcacattc tctcattcca gaccctttta ttctcagtaa 688321 ctatgctgaa gggtggaagg gcattgcggg acagccgttt ctgacgttta ttaaaaactc 688381 ggcgattatt gtcgggctgt caacaatcgg tgccgtcatg tcatcggctg tcattgcgta 688441 cggatttgcg cgtataccgt ttaagggaaa aaaattttgg tttgcgtgca tgatggggac 688501 gttaatgctg cctcatgaag tgttgatgat tccgcagtat attatgtttg cgaaattaga 688561 ctggctgaat tcctttaaac caattgtcgt tccgcaattt ttcgggcatg cgttttttat 688621 ctttctgatg atccagttta tccggacgat tcccgaggag ctggatgaag ccgcgcgaat 688681 cgacggatgc ggacgctttg cctgcttttg gcggatcatt ctcccgctga ttgcccccgc 688741 gcttgcgacg tctgcgattt tctccttcta ttggaagtgg gaggagctga ttcagccgct 688801 cttgtatttg aataagccgg agctttaccc tgtttcactt gcgctgaagc tttttctcga 688861 tacagagtcg gcttcgaact ggggcgcgat gtttgccatg tcagccgtct cgttattgcc 688921 tgtgattctt gttttctttt tgtttcagaa atatatcgtt cagggcatca gtacgaccgg 688981 attaaaataa aaaggagtgt tgcagatggc acagcttatc tttgatgaag aaaaggtgac 689041 gtcggttatt gaccggatcg tgaaacggac atttcagatg gattttgcgt gggattggcc 689101 gggcggcgtt gcgttttacg gtgtggcgga ggcctatgaa gcgacggaaa acgaggaata 689161 tatcaatctg ttaaaaacgt gggtggatga acagctggag gatgggctgc cgccgctttc 689221 gatcaacgga gtttccattg ggcatacgct tttgttcctc cacaaggtga caggtgatga 689281 cgtgtatttg gaaacagcgg ccgagatggc ggaatatgtg ctgcataagg cgccgcgctt 689341 tggcgagggt atccttcagc atacggtgaa tgcggcagaa tacgtattcc ctgaacaggc 689401 atgggcggat acgctgatga tggctgggct gtttatgctg agaatcgggc gggtcatgga 689461 gcgtgaggat tattttgaag acggcctgcg ccagtttcac ggacatgagg atgtgcttca 689521 ggaccctgtc acgaatttgt actaccacgc ctgggacaac aaagcgcaaa atcatctgtc 689581 ggggatttat tggggcaggg cgaacggctg ggcggcactc acgatggcaa aggcgctccc 689641 gcttattgag gtgacacatc cttcctttat gatcatcgac ggatcgctca gagaccagct 689701 gagcgcgctt gtccggcttc aggatgaatc agggctgtgg catacaattt tggatgatcc 689761 ggattcttat ctggaggttt cggcatcagc gggtattgct tctgctctga tgtcgagcgg 689821 aaagctgtat acaaaatatg tgcagaaatc gcttgccgcc attttggatg cagtggaaga 689881 ggacggacgg gtcagcaggg tatcggccgg gacagccgtc atgaaaaatg ccgaaggata 689941 caaacaggtg ccttacaaac gaatacaagg atgggggcag ggacttgcgc tgacgtttct 690001 tgctgatgtt ttgaaaacga aaaaacgctt gtatcagtaa agatagcggc ggggggagag 690061 ggatgaaaaa acagcctcaa cagaaggaac gggtttctcg ctggaaggga acgtatttca 690121 aaagaaactt tgtcttcatt ttgctgattg cctgtattcc cggattgctg actggcggcg 690181 caatctactt tctttcgatc gacaaggtgg agaaagagct gcagagatcg catgaaacac 690241 aggtggcgcg tgaggtcagc cgaatggatg agaagctggg agtgcttgaa ctggcactca 690301 cccagatggc ctacgattct tcactgatga acggattggc cgagagggat ttggagaaag 690361 actttacgtt ctcctatcaa ttaacgaaaa agctgtttct tttgcgggat cagcagccgc 690421 tgatcgagca ggcttccatc tttctgaaca gcccccggcc acttgtgctg agccctgaat 690481 acagcgcttt gacagaacag gaggcgcttc gcaagtatcg ctcgctgctt gcctcagacc 690541 acagcattta ttggaaacgg tcgggaaacc aagcgatgct gatccagctc attccgggcg 690601 cggcggagaa accgttcggc gcgatcatgc tggcggttga tccgaaagaa atggaatcaa 690661 tcctgcaaag cttgtccccc tatcctgatg gcagtgcgtt gcttttagat caaaatcgag 690721 aggtgctgtt tcatgagggg gaaaaagatt ttgaaaagac tttacttcat gagataaaaa 690781 aacagcctgc tgagaacggc cattttcaga tggaatggaa aggcaaggtg tattctgtct 690841 cctttggaga aatgaaccgg atgcatcagc aatggacctt tgtgtcagcg gcgcctcttt 690901 cagctattac agcgccgatg gtgtttttat caaaagtgat catcgtgatg ctggtcattt 690961 gcatcggttt ggcggtgtgc atgacatggt atgcatcaaa aaaaatctat cgtcccatcc 691021 agcatttgct tggcttgttt accggaggag agaagaaaac atggcaggcg tccgggcagg 691081 atgaattcaa atggattgaa aagagatggc aggatctatc ccttgaaagc cggaagctcc 691141 aacagcagct cctgcggcag acgccccata tgaaaaagag ttttttgcag catctcttac 691201 agagcgattt ttactatgac aacgaggaaa gcctcagatt tcggatggag gaggctggct 691261 ggaacatcgg cggaaacgtg tttcatgtgc ttgatctaca ggtgacaggg ctccgctgtg 691321 aaaaaagcat cttccgtgaa ggtgatgaac agcttgccgt gtttacactg actaatatcg 691381 ctgaggaatt ggcggctaaa cgcgtttttc agctctccat acttgatatc ggccggcttt 691441 ctgtcaccgt tcttgtgatg aaaacaaaca gctctgatct gaaggcgtat ataacggagc 691501 tggcacgcca atttggagat gtaaccggac tatgcctgac ctcgacattg agcagcaaga 691561 cggagcgtgt cacggaaatt ccttctttat ttcaggatgt gaaatgcggc aaatcccgca 691621 ggaagtttgc taaccgggat caggtcattg atttgcaggc cgacttccct cgggatgagc 691681 agttcgctcc ttattaccct tttgagctgg aaaaacaaat tgttcagacc atccggctgg 691741 aaagaaaaca ggaagccaag gaactgatag atggatgtat gaaggaactg tcggaaaaag 691801 cggccataga caggcatgtg cattccgccc tgattcagct gttttcccgc attcaggagg 691861 atattttgca ttccgggctc aatcccagcg aactgtttca gcaccggaat ccgtttcttg 691921 atatttcaga attgcgcgaa cctaacgaag cggcggcctg gctgatggat gtagtggtga 691981 cgccttacct ttccaagctt gagggcagaa aaaacagaca gcaaaagcag ctggcagaac 692041 gtgtgattgc gatgattcac gaacagtata tggcggacat ttcattggaa agctgtgccg 692101 atgcgcttgg catgaattcc tatacgttaa gcaaggcatt taagcaagtg accggcatta 692161 attttatcga ttatgtgacc cagatcagaa tcgaaaaggc gaaagaactg ctggtcaata 692221 cgaataaaaa aattcatgat gtgtctgaag aagtcggcta tcgccacaat tatttcaatc 692281 ggatttttaa aaaacaggtc ggcatgccgc cgggtgtctt caggcaaatg tatcaggaaa 692341 cgccgtgaaa ggagagaaca tgtgatgaag aaaccgattc aagtattttt agcgggggat 692401 tccactgtga gtgactgccc gcctcatgaa gcgccgatgg cggggtgggg gcaggtattc 692461 gggcaattgt tttctgaagg tgtgctggtc cgcaatcatg ccaaaggagg agcgagcacc 692521 aattcttttg tggaggaagg aaggcttcaa gcaattgccg agcacatcac acaaggcgat 692581 tatttgttga ttcaattcgg ccacaatgac caaaaaccgc gggggacgaa gccgtactcc 692641 acatttcagc agtttcttac cttgtttgca gatacggcac gcgaaaaggg cgcgcatcct 692701 gtgttcgtca catcggtgca gcgccgccgc tttgatgaaa acggacggat cgagcatacg 692761 ctcggtgagt atcccgatgc gatgaaagca ctggcgaagg agctcgatgt acctgtgatt 692821 gatctgcttg cgaaaacaaa ggtgctgtat gaagcatacg ggccggagga gtcgaagcga 692881 ttgttcgttt ggtttcagcc gaatgaacat ccgaattacc cggacggcat tgaggacaat 692941 acgcattttt cggaaaaagg tgcaatggag gttgcgaagc ttgtggcaga aggcattgaa 693001 gagctcggac ttccgcttaa ggaccacctt gtgagccggg agggaaaaga acatgtataa 693061 ggaaggcgct tgcttgtacc gcaatccgct ccggtctaaa agcgatgtga aggattggcg 693121 gatggaggga ggcggacaga tctcatttga cgatcacagc ttgcacctgt cacatgtcca 693181 ggatgaagcg cactttgtct tttggtgtcc ggaaaccttt ccagacggca tcattgtgac 693241 atgggacttc tctccgatcg agcagcctgg actgtgtatg ctgttttttg ccgctgcggg 693301 tattcgcggc gaggatttgt ttgacccaag tctcaggaaa agaacaggaa cataccctga 693361 gtatcattca ggagatatca atgccctcca cctgtcgtat ttccgcagaa aatacgcgga 693421 ggaaagagcg ttccgcacct gcaatttaag aaaaagccgc ggtttccatc tcgccgcaat 693481 gggggccgat ccgctgcctt ctccagacga cgctgattct ccgtatcgta tgaagctgat 693541 caaagacaaa ggctatgtgc acttttcaat caatggtctg cccattcttg agtggatgga 693601 cgacggcagc acatatgggc ctgtgttaac aaaaggaaaa atcgggttcc ggcagatggc 693661 ccccatgaaa gccgtttaca gggattttgc cgtgcatcaa gcggtgagaa gatgaagacg 693721 actgtaacgg atgcgcttta tgcaggctgc gaagcggtgg tgaaaatagc atggctcaac 693781 gggctgtggc tgttgtttac acttttgggc ggcgttcttt tcggatgggc gccgagcaca 693841 gctgcgatgt gtgccgttat aaggaaatgg ctgatggggc aaaaggatgt cccgatattt 693901 tcgttatttc tcgataccta taaaaaagag tttctcaagg ttaatgcgat cggattggcg 693961 ttttcggctc ttttgctcat attgtctgcc aactatcatt atttttctgc cagtacgaat 694021 tggctgtcct ttgccgtaac aagctgcacg ctgcttgcag ggcttttgta tatcatcgcg 694081 ctgatgtatg tgtttcccct ttatgtgcat taccagctcc cgcttcgcaa atatattccg 694141 caggcactgc tgtttggcgc catgagaccg ctgacaactg gctgtatgct gatcgggtgc 694201 ggatttgtcc tttatttgct gtatacgctt cctggcctga tcccatttta cggcccgtgt 694261 ttatttgggc ttgtgttgat gttttttgct cttaggggat ttcaaaagac ggaggcccag 694321 caccatcaag ccgggtaaca aaaaaatgac aaataagcaa aaaagtgcag tgtccgaaat 694381 aggcagatgc aaaaaagtga aattgaagac agctcacaaa gcgcataaaa tccaatttaa 694441 gtaagcgctt acagataaat gagaaggagc tgtctgatga ttagacgaag gaaacgcatg 694501 tttaccgctg ttacgttgct ggtcttgttg gtgatgggaa cctctgtatg tcctgtgaaa 694561 gctgaagggg cagcgcggca gatggaagcg ctgaaccggg ggcttgtagc ggtcaagacg 694621 gacgggggca tttttgtcag ctggcggttt cttggaaccg aaaacgcatc tgttttgttc 694681 aatgtgtaca gagacgggca aaaactgaat gctgcgcctg tcaaaacaac gaactatgtg 694741 gataaaaacg gttcggcggg ctcaacgtat acggttcggg ctgttgtaaa cggtaccgaa 694801 cagccggctt ctgaaaaagc ctccgtatgg gcgcagccgt atcattccgt cccgctggat 694861 aaaccggctg gcggcacgac gccaaagggt gaatcttaca cgtacagcgc taatgacgca 694921 agtgttggcg atgtggatgg tgacgggcaa tacgagctga tcctgaaatg ggacccgtcc 694981 aactcaaaag acaattcaca ggatggctat acgggtgacg tgctgattga cgcgtataaa 695041 ctggacggca caaagttatg gcggatcaat ctcggcaaaa acatcagagc gggcgcgcac 695101 tacacccagt ttatggtgta tgaccttgat ggtgacggaa aagcagaagt ggcaatgaaa 695161 acggcagacg ggacaaaaga cggcacgggc aaagtaattg gaaatgccaa tgcagattac 695221 agaaatgaac aggggcgtgt gctttcaggc cctgaatatc tcactgtgtt tcaaggttca 695281 accgggaaag agcttgtcac cgcaaatttt gaaccggcgc gcggcaatgt gtcggattgg 695341 ggagacagct acggcaaccg tgttgaccgt tttctcgccg gcattgccta ccttgatgga 695401 cagcggccga gcctgatcat gaccagaggg tattacgcta aaaccatgct agttgcctat 695461 aacttcaggg acggaaagct gtcaaagctt tggacgctgg actcctcaaa gtcaggaaat 695521 gaagcgtttg ccggacaggg gaatcacaac ctgagcatcg cggacgttga cggggatgga 695581 aaagatgaga ttattttcgg ctcaatggct gttgatcatg acgggaaagg catgtactcg 695641 accggcttag gccatgggga tgccctccat acaggagatc ttgatccggg ccggccgggg 695701 cttgaggtgt ttcaagttca tgaggacaaa aatgcaaaat acggcttatc tttccgggat 695761 gctgcaactg gaaaaatcct ttggggcgtt tatgccggca aggatgtagg ccggggaatg 695821 gctgctgata ttgacccgcg ttatccggga caggaggtgt gggcaaacgg ttctctctac 695881 tcagcgaaag gggtcaaaat cggaagcggg gttccgtcct cgaccaactt cggcatctgg 695941 tgggacggcg atctgctccg ggaacagctg gacagcaacc gaattgataa gtgggattat 696001 caaaacggcg tatcgaaaaa tatgctgact gcatcaggcg cagcggctaa caacggcaca 696061 aaagcaacac caacgcttca ggctgatctg ctcggtgact ggcgcgagga agtggtgtgg 696121 agaacggagg acagcagtgc tctgcgcatt tacacgacga ccattccgac tgagcacagg 696181 ctgtatacgc tgatgcacga tccggtgtac cggcttggca tcgcctggca aaatatcgcc 696241 tataaccagc cgccgcacac aagcttcttt ttaggagacg gcatggcgga acagccaaaa 696301 ccaaatatgt atacgcctta actgaaaggg ggaaggaacg ggctgcgcgc agcccgttcc 696361 catcaaatga aaccaaaaaa gaggcaaatg gaatacctga ccagaggttt gattgcggta 696421 cagacagaac agggcgtgtt tgtcagctgg cgttttctcg gcacggatca tgagacgacg 696481 gcttttcacc tttatcggga tggaaagcgg atcacccgcg atccaatcgc tgaaagcact 696541 aattttctcg atcaaaacgg aacggctgac tctgtttatc aagtggcggc tgtcaataaa 696601 ggacgggaag aaaagctttc caagaaagct cgtgtttggc aggaaaatgt cctggaggtt 696661 cctcttgcca aaccggaagg cggtgtgacg ccggacggaa agccgtacac ttacagcgcc 696721 aatgatgcca gtgtcgggga tatagacggg gatggagaat atgaaatgat cctgaagtgg 696781 gacccgtcca attcaaaaga caacgctcat gacggttata ccggggaggt gctcatagat 696841 gcctataaac tggacggcac ctttttgtgg cgcatcaacc tcggcagaaa catcagagcg 696901 ggtgctcatt acacgcaatt tatggtgtat gaccttgacg gtgacggaaa agcagaaatc 696961 gccatgaaaa cagctgacgg cacaacagac gggaaaggac atatcatcgg tgatgagcag 697021 gccgatttta gaaacgaaca gggcagaatt ttgtccggtc cggaatattt gaccgtgttt 697081 aaaggagaaa ccggtgaggc gctcacgacc gtggaatatg aaccgccccg cggcaagctg 697141 gaggattggg gagacggcta tggaaaccgg atggaccgtt ttctcgccgg gaccgcttat 697201 ttggatgggg agcggccgag ccttgttatg gcgcgcggct actatacgag aaccgtgctc 697261 gtggcatacg atttcagaaa cggaaggctc aaaaaacgat gggtatttga ctccaaccag 697321 ccgggacatg aagcatacgc aggacagggg aaccacagct tgagcgtggc ggacgtcgac 697381 ggagacggaa aggatgaaat catatacggc gcaatggctg tcgatcatga cggaaccggc 697441 ctgtactcaa cgggcctcgg gcacggagac gcgatgcatg taggggatct ggacccgtca 697501 cgaaaagggc ttgaagtgtt ccaggtgcat gaggacgcca cgaagccgta cggactgtcg 697561 ctgcgagatg ccggaaccgg tgagatatta tggggcgtcc atgctggaac tgacgttggc 697621 cggggcatgg cggctcatat tgatccaagc tacaaaggat cgctcgtctg gggaattgat 697681 ccgccgggca atgatggcat gtcgtacggg cttttcacga gcaaaggcga aaaaatcagc 697741 gacaaagcgc cctcttcagc caatttcgcc atctggtggg acggtgattt ggtcagagaa 697801 ctgcttgatc atgactggga cggaacgatc ggcaggccaa agattgaaaa atgggatgct 697861 gaaaacggct gtctgaagac gatatttcag ccggccggcg tgttgtccaa caacggcacg 697921 aaaggaaacc cggttcttca ggccaacctg ttcggagact ggcgggaaga agtgatatgg 697981 agaacggaag acagcagcgc gctccgtatc tatacaacaa cacatctcac ccgccactgc 698041 ttttacacgc tgatgcatga tccggtttac aggctcggca tcgcctggca gaataccgcc 698101 tacaaccagc cgccgcacac gagcttttac ctcggaacgg gaatgaaaaa accgccgaag 698161 cccgccctgt acatagcggg aagcaaagcg gaggcgccgc tgtaggagga ctaagggata 698221 agacgcaaag gctgaacgct acgccaagat gattagagaa ctggcaggac gaaccaatgc 698281 tcaagcgctg tacgcaccgg ttttttcaag ggaagagcta tccgtgatgg aagctgtata 698341 aaaaacgagg aggaatgaaa aaatggcaaa tcatatttat cttgccggcg attcgactgt 698401 tcaaacgtat ggagacagca caaatcaagg gggctggggg cagtttctcg gctcgcatct 698461 gccggagcat attcaagtga tcaacagagc gatcggggga agaagctcga aaacatttgt 698521 ggaagagggc aggcttcagg caatcctcga tgtgattgag ccggatgatt ggctgttcgt 698581 gcagatgggc cataatgacg cgtcaaaaaa taagccggag cgctacaccg agccctatac 698641 tacttataaa caatatttaa agcagtatat cgcaggcgcg cgggaaaaag gcgcccatcc 698701 gcttctcatt acccccgtag cccgctttca ttacgaaaac ggcgtgtttt tgaacgattt 698761 tcctgattac tgcattgcca tgaagcagac ggccgctgag gagaatgtcc agctcattga 698821 tctgatggag aaaagtctcg ctttctttac tgagaagggc gaggaaaaag tgtacaccta 698881 ttttatgatt tcagaaggga ttaacgatta cacgcatttt acaaaaaaag gcgcaaatga 698941 aatggcgaaa cttgtggcaa aaggcataaa ggagctcggc ctgccattga cagaatcgat 699001 catcaaagaa aggtgaaaat gtgatgagaa aactgtatca tggcgcttgc tattatccgg 699061 aattatggga tgaagagacg attcagcagg acattgacat catgcgtgaa gttggcgtaa 699121 atgttgtgcg gatcggcgaa tttgcctggt cagtcatgga acctgaagaa ggaaaaattg 699181 acgtcggttt tttcaaagaa atcatcgccc ggctgtatga tagcgggatc gaaacgatta 699241 tgtgcacgcc gacgcctacc ccgccgattt ggttctcaca tggccggccc gaacgcatgc 699301 atgccaatga aaaaagagag atcatggggc atggctcccg tcagcatgcc tgtacgaaca 699361 acccgtattt ccgaaaaaaa gccgccatca tcaccacagc catcgccaag gagcttggcc 699421 ggctcccggg gctgatcgga tggcagctag acaatgagtt taaatgccat gttgcagaat 699481 gcatgtgtga gacatgcttg cgcctatggc atgactggct caaaaatcgc tacggggtaa 699541 ttgagcgctt gaatgaagct tggggaaccg atgtgtggag cgagacctat cagacgtttg 699601 agcaagtccc gcagccggga ccggccccgt ttctgcatca tgcctctcta cgcactatgt 699661 atcagctgtt ttcgatggag atgatcgctt cgtttgcgga tgaacaggcc aaaatcatcc 699721 gctgctattc agatgcgccg atcacgcata acggatcagt catgttcagc gtggacaatg 699781 agcgaatgtt tcagaatctc gattttgcct cctatgacac gtacgcttcg caggaaaacg 699841 cctctgcctt tttattgaac tgtgatttat ggagaaatct gaaacaaggg cgcccgtttt 699901 ggattttgga aacgagtccg tcgtatgccg cctcgcttga aagctccgct tacccgcacg 699961 cagacgggta tttgcaggcc gaagccgtat cgtcctacgc cttagggagc caggggtttt 700021 gctactggct atggcgacag cagcgttcag gcagcgagat ttcccacggt tcggttctca 700081 gtgcctgggg cgaacccacc atcggctatc aaaatgtgct ggcggttgag cgggcaagaa 700141 aggaaatcga gcctattatt ctatcgactg aacccgttca agccgaggcg gcgatgactt 700201 actctgacag agcaaaagca tttattaaaa ctgagcctca ccggggactc cggcatcgtt 700261 cgcttgtgac gcatttttat gaacgtattc tcaacacggg gattcaccgt gaccttattc 700321 cggaaggcgc tccactggac ggctatcgct tgctgtttac gccatttgtg ccgtatttgt 700381 cttctgaatt tatcaaaaaa gcttcggcat tcgctgaagc gggcggcatc tggatcaccg 700441 ggccgctgac aggaggacgc acatgcgagc ataccattca taccgattgc ggacttggcg 700501 aacttgagaa aacgtcaggg atcaaaacac tttttacctt tccgatgaat gagaacgtga 700561 atacaggaaa agcgtttggc atcacggcgc cgctcggact gtggagcgcg gtgtttgaca 700621 cagagagcgg aaacaccctt ggcacggttg aagcaggacc gggggcgggc catgcttttc 700681 tgacggaacg gaattacggc gaggggaaaa ttgtcatgct gggctcgctt ccatccggga 700741 aagaagggga tgcgatgctg gaagcgctcg tcaggcatta tgcggaggaa gctgttattt 700801 ccagccggtc ggatgtgaca cccggcacga tcgttgcccc gcgtataggc gaaaacggcc 700861 ttgtgtggat cgttgtgaat atggatggaa aaggcgggag cgtgacattg ccggaatcgg 700921 gaacggattt gttgacgcac cgcttggaaa aggcggggag actggcggtc ggaccgcatg 700981 aataccgtgt gattcaattt gacaatcaca gctgattctt tgtatcgaat cagctttttt 701041 ctatggaggg agagacagat gaaaaagatc aaatggttat caggacagcc aaaggtgaca 701101 agcggcgtga cgtggggcat gccatggaaa aaaggagaat taaaaaaagg agaccgtctg 701161 gcgcttatga atgaaaacgc ggaaacgcga tatgtgcaaa gcgaaccgtc ggcctattgg 701221 ccggacggga gcatcaagtg gacgaagcac gcggcggtgt ttggcggtca ggaaaaccaa 701281 agctttacag tgcacaaaag agaagtgccg cagccaactg aatcgctcag cattcttgag 701341 acagagcatg atatccaagt ggatacagga gcactcgttt gtaccattca taaaacagga 701401 tctgatttca ttcaatcatt gcagatcaat ggaaagccga tcgccgcagg cgggaggctc 701461 gttgcgataa gagaaacgag aaaagagtca gcggcgaaaa tggttctttt gcatgaaagg 701521 tctgtcagct ttatcaaacg ggcggcgatt gagcagagtg gtcctgtcaa agcagtagtc 701581 aaaatcgagg gagtgcatgt gcttcataaa acgtatgagg aatggctgcc gtttgtcatc 701641 cgattaacgt tttatgccgg gctgtctgag atcggccttg tgcacacgca gctgattgac 701701 aggagcggta aactagaatt cgttaagggg ctcggcatcg aattcgacct ttttttggag 701761 ggagagccgt acaaccgcca tttccgcttt gcgggagaga aagggatgta taaagaaccc 701821 gcccagctgt ttggcacacg taaattcaat gaacgatatc cgctttatga aaaacaaatc 701881 aatggcgaaa tgctgtctcc agatgaagag cataaggaat ggtttgcaca tggcacacag 701941 aatgcggttt gggacgatgt caagatcgtg caagattcca gcgatcatta cagcctgtca 702001 aaacggaccg gaaaagatta tgcgtgggtt ggaatgctgc atggcagccg ggcgaagggg 702061 ctctgctatg cgggcggaaa aaatggcggt gtggctctcg gcctgcggta tttctttgag 702121 aaatatcctt cagcactgga aatcacaggt cttgccggca gccgccccaa aatgactatc 702181 tggctttggc ctccggacgg cgaagcgatg gatttgcggc attatacagg aaacactcac 702241 gtggccagcg cgtatgaagg ctttgatgaa atgcgctctg atccgacagg cattgcgaac 702301 acaaatgaaa taagcctggc gtgcttttcg cacatgccgt ctgacgaagt cctcaatgcg 702361 ctggctgaca aatggcaggc gcccccgctc attgtatgcg agccggacgt ctattacgaa 702421 tcaaaagcac tcggggtatg gagcatcatt gacacatccc atccgctcaa aaaagagctg 702481 gaagaacagc ttgatgcggc ctttctgttt tataaaaagg aagtagagca acgcagatgg 702541 tacggttttt ggcattatgg cgatgtcatg catacgtatg acccgatccg gcatatgtgg 702601 cggtacgatc tcggcggata cgcatggcaa aacaatgagc tcgttccgac cctatggctg 702661 tggcaggcgt ttttccgctc aggcagagag gatatcttcc gaatggcaga agccatgacc 702721 cgccatacga gtgaaacgga cagctttcac ctcggtgaat atgccgggct tggctcacgg 702781 cataatgttg tgcactgggg atgcggctgc aaggaagcga gaatcagcat ggccgggctt 702841 cataaattct attattatct gacgggtgat gaccggacgg gagatctttt gacagaagtg 702901 aaggatgccg attatgccct tgtcaaaacc gatccgatgc gcgcttttta cgagaaaggc 702961 aagcacccga ctcacgccag aacgggaccg gactgggcgg cgttttgctc gaactggctg 703021 gcggaatggg agcggaccga aaattcggaa tatctcaaaa aaatcgaaac gggaatcaac 703081 tgtctgaagc ggctgccgct ccgcttatta tctggcccga catttgaata tgatccggcg 703141 acctcgatgc ttcatcatat gggagacggc attgcgggcg gatatcatat gatcattgcc 703201 ttcggcgcgc cgcaagtgtg gatggagctg gctgagcttc ttgatgactg ggaatgggag 703261 gatatgctga gtgaattcgg cgaattttac acactcagtg atgaggaaaa acgaaaaaaa 703321 agcggaggcg ctcttcatga cgggcatttt cactggccga tgttcgccgc cggtatgaca 703381 gcctacgccg caagaaaaaa gcaagatcct catctcgccg ccaaagcgtg gaatcttttg 703441 ctagaagata agctcagcca tacgccgctt ccgatcaaac cggagcgcat cgagacatgg 703501 acgcagctag aggagcttcc atgggtgaca acgaacactg tctctcaatg gtgtttaaat 703561 gtcatagcgg cgctggaact gatcggagat tcccttccgg caaaaaaaga aacatcgggc 703621 aaaaaaggat aacagccgga atttcatagg agaaatggtg caaaaaatga agattgcaag 703681 aatttatgta agcgctttat attgagaggg gcaaagggga aatgcaaatt gaaaaaaggg 703741 ggacttacgc aacatgaaaa taagaatgcg aaaaaaatgg atggccttgc cgcttgctgc 703801 catgatgatc gccggatgca gccattcgga aacatccaat tcagcaagcg gttcgaaaga 703861 tacgatcaaa attatggcgc cgctcttatc gccggaaagc ccaagtgata agagcccttc 703921 attaaaagcg ctcgaaaaat acacaggcaa agagattaag gtcacatggg tgcctgattc 703981 atcctacaac gacaaattca acatcgtcat ggcttcagga gagatgcctc acgcgattgt 704041 cattaaagat aagtcagccg gctttatcaa atctgtcaaa gcaggggcgt tttgggagct 704101 gtctccttat ttaaaagact acaagaattt aagccaggca gatgaaaaga ttttgaagaa 704161 cagctcggtg aacggcgagg tgtacggaat ctacagaacg agggatctga tcagggcgtg 704221 tatgatcatc agaaccgact ggctgaaaaa tgtcggtctg gatatgccgg aaacgcttga 704281 tgatttctat gaagtgctga aagcctttaa ggaaaaagat cctgacggaa acggcaagga 704341 tgatacgtac ggcatggtcg tgccgaaatg gatgggactc ggcaacggaa gcccatggga 704401 tgttctgcaa atctggttcg gcgctccgaa ccgctacggt gttgaaaacg gaaagctgat 704461 tccagatttt acaacgaagg aatacatgga tgcgctcacg ttttttaaaa agctctatga 704521 tgagggcttg atcaataagg actttgctgt catggattct gcgaagtgga atgatccggt 704581 tgtaaaagga aaagcgggtg tcatcgttga tacaggctca agagcgtctc aaatccaaag 704641 cgcgatggag gaggcggatg agtcgaacaa ggatatcatt gatatcgtcg gctcgcttga 704701 gggaccgaat ggcaagcgca ccttcccgac atctggttat tcaggcatga tcacgatacc 704761 aaaatcaagc gtcaaaaccg aaaaagagct gaaagaggtg ctgtccttcc tcgataagat 704821 gaatgataag gaagcgcaga ttctcacgaa caacggagtg aagggccgca attacgagct 704881 caaggacggc gtattcacct cacttgaaaa aaacaataaa tctctcctgt atgagcatga 704941 aggcttggca cagttcagca tgtcgattcc gaaaagcgag tattacatcg aagaccagaa 705001 aaccaagctc ttccagcatc gcaaggacat cataaccgaa ggagaaaaaa tagccgtctt 705061 taaccctgct gagtcgcttg tatctgatgt ctatacccaa aaaggagccc agcttgacaa 705121 catcatcctc gacgcgagaa cacaatttat cattggagaa attgatgaaa aagggttcga 705181 tgatgcggtg gagctttgga aaaaaagcgg cggcaatgaa ctgatgaagg acttgaacaa 705241 attgtaccaa tcgtcaaaat aaaccgatgc gcctgccttt cggcgggcgc cccggtatca 705301 cgaaaggaga acagatatgg aaacagtgcc gaagaagaga gatgcacctg ttctcaccgc 705361 tggaaaaggc atcagctgga tggctgcgct caaacgggac aaatggcttt atcttcttct 705421 tattcccggt ctgctttatt tcttgatttt caaatacttg ccgatgtggg gtgtgctgat 705481 cgcttttaaa gactattcgc catatctcgg cttctggaaa agcgaatggg tcggctttga 705541 ttatttcaaa gactttttta tgaatccgga ttttttccgg ctgctgcgca acaccctcat 705601 gctggcgagt ctggatcttt tgtttgcctt tcccgcgcct ctcattttgg ctctgctttt 705661 gaatgaggta agaaaggccg tgtataaaag atgtatccaa acctttattt acgtacccca 705721 ttttgtatca tggacaattg tggtcagcat caccttcgtt ttctttactg tcgatacagg 705781 tgtgatcaac aaattgatta tgagcctgac aggtgagcag atttctttct tgtcggatgc 705841 agactggttc cggccaatga ttgtgatgca aagcatttgg aaggagacag gctggggaac 705901 gattctattt ttggcagcgc ttgctacggt tgatcaagag cagtatgaag cggccatcat 705961 ggacggagcg gggcggttca ggagaatgtg gcatattacg ctgccggcga ttagaagcac 706021 cattatcgtt ttgttgattt taagaatcgg cagctttttg aatcttggct ttgaacaggt 706081 gtatttgatg acgaactcac tcaaccgcag tgtggctgac atcttcgaca cgtatgtgta 706141 catgatgggg attacccaag gggcgtatag ctacagcacg gcggtcggtt tgtttaaatc 706201 agttgtcggg attatcttga tttttggcgc caattacatt gcgaaaaagt ttgatcagga 706261 aggattgttt tagaggaggg agaggtatgg ctgaaattca cacgatgcac aacaccaaag 706321 ccggacgggt gtttgacgtc tgcaacattc tgtttctcgg cggtgtcggc gcgattacca 706381 ttttgccgtt tttatatatt atcgccggtt cctttgcgac agaagcggaa ctcgcccagc 706441 ggagcttctt tattttcccg aaaaccttta cacttgatgc ttacaagtat gtgttttcga 706501 caccgacgtt ccttcgaagc atgggcgtgt ccatcttcat cacggtggtt gggacggctg 706561 tacagctgtt ttttaccttc acgatggcgt atccgctggc gaaacggcat gtgaagggac 706621 ggaatctgct gttgaatctg gtgattttct ccatgctgtt ttcaggcggc atgattccga 706681 cgtaccttgt cgtaaaatca cttggccttt tggatacgta ttgggcattg attctgccga 706741 tggcgattaa tccgttcaac cttattatta tcaaaaactt ctttcagcag ctgccgcgcg 706801 agctggagga atcagcaaaa attgacggct gttccgaaat cggcgtcttc tggcggatcg 706861 ccctgcctct gtcaaagcca gttattgcga cctttgcgct gttttatgcg gtcgggattt 706921 ggaatgattt cttccacgct ctcttatata tcaatgacag tgcaaaatgg ccgctgcaaa 706981 tggtgcttcg ccaagtcaca attttatcgg atttaacggc gaccaatggt gatacgatgc 707041 aaaatgcagt tccgccggag cagggaatta aactcgctgt cattgtcatt gcgacgctgc 707101 cgattttggc ggtctatcca tttttacaaa aacactttgc aaaaggaatg ctgatcggtt 707161 cggtgaaagg ctgagaaagg gagtgtttca tatcagtaca ttagatcaga ttaagattgc 707221 ctatatcggc ggggggtccc aaggctgggc cagaagcctg atgagtgatt tgtcgattga 707281 tgaacggatg tcaggcacgg tggcgctcta tgatcttgat tttgaagccg ctcagaaaaa 707341 tgaagtgatc ggcaatcaca gcgggaacgg cagatggaga tatgaggctg tttctacttt 707401 gaaaaaggcg ttatcagccg cggatatcgt cattatttcc attttgccgg gatcactgga 707461 tgatatggaa gtcgatgtgc acttgcctga gcgctgcggt atttatcagt ctgtaggtga 707521 tactgtcggg cctggaggga tcatcagggg cttgcgtgct gtgccgatat ttgcggaaat 707581 tgcccgggca ataagagact acgcacctga atcatgggtc attaattata caaacccgat 707641 gtctgtctgt acaagagtgc tgtataaagt gtttcccggc atcaaagcga ttggctgctg 707701 ccacgaggta ttcgggacgc aaaagctatt ggcggaaatg gtcacggaaa ggctggggat 707761 tgaggtgccg cggcgtgagg atatccgcgt taatgtgctc ggcattaacc attttacatg 707821 gatcacaaaa gcctcttacc gccatattga cctgttgcct atattccgtg aattcagcgc 707881 gcactatggg gaatcaggat atgagctgga gggggaatgc tggagggaca gcgtcttttg 707941 ttcggcacac cgtgttgcgt ttgatttatt tgaaacgtat ggcgccatcc ctgctgcggg 708001 tgacaggcat ctggcagagt ttcttcccgg cccatacctc aaacagcctg aagtatggaa 708061 atttcatctc acacctatat cattcagaaa acaagacaga gctgagaaac gacaagaaac 708121 agaacggttg atcgtgcaac aacggggcgt tgctgagaaa gcttcgggag aagaaggcgt 708181 gaacatcata gcggctcttc tcggattggg tgaactcgtc acaaatgtaa atatgccgaa 708241 tcaaggccag gtcttaaacc ttcctataca agccattgtc gaaacaaacg cattcatcac 708301 aaggaaccgt gtccagccga ttttgtccgg agcgcttccg aaaggtgtgg aaatgctggc 708361 ggctaggcat atatccaatc aggaggcagt ggcggacgca ggtttaacaa aggatactgg 708421 cctcgcgttt caagccttcc tcaatgaccc gcttgtccag attgaccgca gtgatgcaga 708481 gcagcttttc aatgacatgc tccaatgcat catgcaaagc tgagcttgcc gattagctct 708541 ttccggttta gaaaggaaag cattgaccat actgatagta taatcaagaa gtaggtgcta 708601 tcaatatggg aaattattta agtgttgcgg tagaactggt ctgcggttta ggcattttat 708661 ttatcatctt aaagcttctc gggaaaaccc aattttctca aattacgccg tttgacttta 708721 tttctgcttt aattttaggt gaattggtcg gaaatgccgt ctacgatcat gaaatcaaaa 708781 tcaaagaaat tatttttgct tcgctattgt ggggcgtgct gatttatatt attgaattta 708841 tcacgcaaaa aatgaaatca tcgcgaaagt tcttggaggg cgagccgaat atcgtcatcc 708901 gcaaagggga gcttcaatat aaagtaatga agaaaaataa gatagacatt aaccagctgc 708961 aaagcctatt gaggcaagct gggagctttt cgatccaaga agtagaatat gcgattcttg 709021 aaacaaacgg gatggtcagc gtgcttccaa aatcagactt tgacaaaccg acaaataagg 709081 atttgcagat tccttcgaag tccgtttctc tgccgatcac gttaatcata gatggagaga 709141 ttgtgcggga taatttgaag gaagcaggtg tggatgaaca gtggctgaaa caagaattga 709201 aaaagaagaa cattgataag acagaggacg tgttatttgc agaatggcat aaaaataagc 709261 cgctgtatac tgtaacgtac gaacaaagca gatcaacatg actcttagaa aaaagcttgc 709321 agcaaggcgc aagcttttta ttgattgtat gtcccttgtt tgacagcacg tacatggtac 709381 atgctcactt cagtgctgat cagatagtca ggctttggtt tgcctttgtt tgctttatgg 709441 ccggcgatat gcgcatcgct tttttcccat tgcttccagt gatcctctga ttcccagcga 709501 atcatgacaa caacttcttc atcaccgcgg cgcacatttt tctcaagcac tgtcacatca 709561 attaaacctt cttgtttttc aatgattcct tcagcgctga aacgttctat gactttatct 709621 gcaaagcctt ctttaaccgt catttttctc aactgtacaa acatttgtct cactccaatc 709681 attctcacat atgaataatt gtaaatgaaa ttcattctca atgtcaaaga aagcgcaggg 709741 cggaatcgaa ccgccgtgcg caacagttta ttcttttaat aaaaacacat ttccgtcttc 709801 gtccttaaat tgaacgaagg tgccccactc catttgattg ggctcaccga gaaattctac 709861 accgtttgtc ttcattttct cgtatgtacc aaagatgtct tcgcattcaa acacaataga 709921 agccttcatt tgctctgagc ctttcatcat ggctttcggg taaatgacta aacgagtctc 709981 ggctcctttt ggcgcaacct ccagccagct tgcttcaggt cccattgggt gatccgctgc 710041 aatatcaaag cctaccttct ctgtccaaaa ttgcttcgct ttctgctggt cctcgacata 710101 tacagcaaca gtgccaattt gtttgatcat agggaaacct ccaagttgaa aagataataa 710161 tactataacc tgtttacggc cgaagtaaca taaaaaaatc agccgggaaa ccggctgatt 710221 attaaaatga gcagcttaca acatcgatgt gatttgtgtc taaggcgaaa taaacccagc 710281 ggcgccgtga ggaatcccaa taaaagccgc cgacggatct tctgccaagg atgatcgggt 710341 aaaaccaaaa tgagcggcca ttggttaacc agacataggt aaatcggaaa aggcaaggac 710401 gaatggtgat tggttcaact aacaaaacgg ctccttgaga accctgcggt tttgggggtt 710461 tcgctggtat ttgggaagga ggaggtccct gcggcgcacc gccgaagcct gggctggcac 710521 cgctgccaat accagggccg gagccgccgc caaagcctgg aacagcacca ccgccaatgc 710581 caggaccgga gccgccgcca gagcccggaa cagcgccgct gccaatgcca ggccatggat 710641 atcggtattc atattcaaaa gcaggccaag gctcataaaa atgccccgca aacatataag 710701 gatcaacata atacatgtga taacgtcctt tctcattgta aactgtacat tgcagtttat 710761 gcgggcggac tcttattggt gcattcgcct aaggatatga agctggaatg ctctcagaga 710821 gcagaatcat ttgatttttc tctagtctta ttcacaattc cgatttatca ttttataatg 710881 aaagtgcttc tattacgaaa aaggagacag accgtgaata tcgatcaatt attatatcaa 710941 tatatcatag acaacactgc ggatattact gagaaatggt tcagtttgcg ttgccagcta 711001 aaaggcgagc tatattccgc cagccattta agtgaagaaa cgaaaacact tttaaccgag 711061 cagcatacat ttaccaatat aacaatcgca agcgcatttc tggaggatca aaccgatttt 711121 caagaaaaca tgacaaaatg ggcgcaaaac gttgcgaaaa acagggtaga gcaggatgtt 711181 caagtgcatg aggtcgtaga agccatatcc aattcaagaa tctcattctg ggacgcagtc 711241 gccacattta taaaagagaa tcaggagatt gtgacaaatg aggatgcaga ccgatggaac 711301 cgcattgtga atcagtcgtt cgataagctg attattgaat tctccgagca gtaccaaaaa 711361 ttcatgctga tgaggcttac atctcagcag gaactgatct cagagcttgg ctgcccggtc 711421 atttccattg ccgatggaat cgggatattg ccgcttatcg gctccattga tacaaaacgg 711481 cacaggtcat tttagaaaca gtgccggtcc gctgtgtcga gagaaaaatc acaagcctcg 711541 tcgttgatct ttcgggtgtt ccgattgtgg ataccatggt ggctcagcaa ttgtacaacc 711601 tgtctaaaac acttttctta ttaggcgtca aagccgtatt ttcaggaatt cgcccggatg 711661 tggcccaaac atcgattcaa ttggggcttg attttagtga atatgaaacg tacggcacgc 711721 tgaagcaggc attagaaaac atgggtgtcc gctgtattgt tgaggaattg gaagaaaaca 711781 aataggaagt ttccaggcat atgattgtcc gtcaccgggt gatcatatgc ctttttgatt 711841 tgaacagaaa tcaccattga tttatcgaaa aaaacataat attataattc ttataagaat 711901 actgtgaatt aaaacctatt caacaggggg gaaggtcttt tggtttctaa atcaacgatt 711961 gatccggaag tgattgaaaa aatcatcagc tcgctggaaa cactcgattt cggcacggtt 712021 cagattacgg ttcatgattc tcagattacc caaattgaga aaatagaaaa gcaccgtttt 712081 tcgctgaaaa ggaaagaatc aaaatgataa tgtaaagggc gtttgttttc attaaattct 712141 ccttaaaaca tatacatatt tcatccaatt tttatataat agacctttaa gatcattttt 712201 taggaggatt tttgacatgc aagctacggt tcacgagagt aagcaatcga tcatgcaacg 712261 cattttgaca gtctttgtct tcacattgct gatcgcgact gtcggccttt ttatcggcca 712321 atttgttcct gtcgctttga tgctgccgct ttctattctt gaagtggcga tgattattct 712381 ggccttctgg atgcgcagaa gaaaagcggt cgggtatgcg tttgtatata cattcgcgtt 712441 cgtttccggc attaccttat ttccgatcgt cagccattac gcttccatcg ccggcgccta 712501 tgtcgtgctc gaagcctttg gctctacatt tgtcattttt gccgtcttgg gcacaatcgg 712561 cgcaaaaatg aagaaggatt tatccttcct gtggtcgttt ctgctggttg cggtgctcgc 712621 actcgcagtg gtagggattt tcaacatttt cagcccgtta aactcagcgg cgatgatggc 712681 gtattccgtg atcggaacca tcgtcttttc cctttacatt ttgtatgatt tgaaccaaat 712741 caagcaccgc cacattacgg aagacttgat tccggttatg gcgttatcgc tgtacctaga 712801 ctttatcaac ttgttcatca acctgctccg cttcttcggc attttgagca gtgatgatta 712861 atgaaaaagc gtctgtcatt ggataggcgc tttttgccat acatcaaaaa ggcaggtgga 712921 gtattggtga aaaaacaaat gggcgcatat gtatctctgg cagcagctat ggcgatcgtc 712981 ggcagttctg tcgttgtcgg caagctgatg gtcgaacgga ttccggtctt tctttcctca 713041 ggattgcgtt ttttgatcgc ttctgtcgta ttgctcatgc tgctgttttg cattgaaaaa 713101 gggtttccgg ctttgacgaa aaaagatgtg ttcgtattac tggtgcaatc attcacaggc 713161 gtgtttttgt tcagtatttg cctgctgtat ggggttcaat atacgacggg aacggaaagc 713221 ggcattttga caagcacaac ccccatgttg atcggtattt tatccttttt cctgctgaga 713281 gaaaaaattg agaaaaagac gctgatcggc attttgctgg cggtttgcgg cgtaatggcg 713341 attaatttgt ttggagccgg gagccaagac gggacgccgc acgccttatt cgggaacatg 713401 ctgatcattg ctgcagtcat tggcgaagcg ttgtttacat tgatggccaa gctgctatcc 713461 ccgcatattt cggcactggc gatttcgacc ttcgtatcgc tcttcggctt cctgtttttt 713521 ctcccgtttg ctttgtttga ggcctcttca tttgattaca gcgtgccgac tgttttggat 713581 tggtcgtatg tgctgtatta cgcgcttttt gtcactgttt tggcgtttta cttatggtat 713641 agcggggtga cgaaggtgcc ggcgggtgta tcgggcattt tcacatccgt tcttccggtc 713701 tcagctgtca ttttgtcagg cgtgatattg aaggagccat ttgagtttgt gcatttcatc 713761 ggcattgcat gtgtcatcgg cggcatattt gttacggtca taaagaaaaa acagccggat 713821 gcgtatccgg ctgcagaaga aaagacgcta tagcctgtcc ggatcggacg ggttttttag 713881 tctttaaaca cgctcagcct ttcaaaaaga tcaccaagca tcttcacgaa catgtctttt 713941 tcctcgtcgc tgtagttttc catgacagcg gatattttgc tgaaatggcc gggcagaaat 714001 tgctccaggc gtgctttgcc ttctgttgtc agttcaatgc tgatttttcg tttatcctct 714061 gtgtgatgcc tgcggctgac aaaaccgtct ctcgccagcc cgtctagcag gcctgtaatt 714121 gttgctttcg tgacatttga ccgcttggca agctctgtcg gacttaacct atgatccttg 714181 gcatcaaaga gcagcatcag gattttgaat tttccttctg aaagccctcg gccagcaaag 714241 taatgctcca tcacatgatt catttttttt gaaatatcaa aaagagataa aaacaattca 714301 agagagccgg cgtcaatatt ggcatacgtt tcggcgtgct ctgttatatg cttatatttc 714361 ggtaaatgtt ttaattccat cgcaattagc tcccgtacat tcgttgtgac acgattataa 714421 aggagggaaa accataacgc aacttggctt ggagatgatt gacagctttt cttgggacat 714481 agtaaggtaa tatagttagg cgcctaacta atacatatag agctgaaaag gtggttattg 714541 atatgaaaca tatgttaata gcaggaggcg gaatcggcgg cttgtcagcg gccatttctc 714601 tccgtaaggc agggttttcc gtcaccttat gtgaagcggc ttcagaaaat cgaaaaacag 714661 gtgcggggat tcttcagccg caaaacgcac tggcggtgtt gaaagaactg ggcgtattcg 714721 aagattgctg taagcacggc tttcaaacag aatggtttaa aacgtttgat gaacagggga 714781 atttgctgtt tcaagtcagt gaatcctttt tagacgattc acttccggga cgcaataata 714841 tcctgcgcaa aacgttaaat gacattctca tgaagcatgc cgaggcagtg ggtgtagaca 714901 tcaagtgggg gaaaaaggtt gtcgcctatg aagaaactgc tgaatcggtc actgccttat 714961 gtgaagatgg agaaaagatg caggctgaca ttctggcggg ctttgacggc attcactccg 715021 ttgttcgtga taagatgctg caaaaggaaa cggaaaaaga gcatctcggc atgggagcgt 715081 ggcgctttta tatcgaactt cctgattaca cattcgagga cgcaacattc atgtatagaa 715141 gcggagacac acaaatcggg gtggtgccat tggcacaaca cgctggctat gtcttcgtcc 715201 tccagccttg cacgagcgat tactgggatg aggaagatac ccggtttgat agagtaaaag 715261 agattctttc tggttttcgg gggctggatt ttgtcacaaa gcacatgtca aaacagcatc 715321 ctgtcatctt taacaaactg gagcaggtcg ccgtgcagga gccatggcat aaaggccgcg 715381 tcatcatcgg aggagacgcc gcccacgccg gtgcgccaac cctggcacaa ggagcggcaa 715441 tggcgatcga ggatgccatc gtcctcgccg aagaactcca aaaccacgcc gaccacgaaa 715501 cagcattaca ggcgtactat aaaagaagag ccccacgagc gctcaaagtc cagaacctat 715561 catctgaaat cgtccgccgc aggctgaaag gagagccggg agcggaagaa ctgattgggg 715621 agtgctatgc ggtgttgagg gaagggtatt aaataggaaa agtccagaaa gtgatttctg 715681 gactttttag tcttgctctg ttttattcct tatccgctca atcacctcat gcagcccctc 715741 aggcttataa aactccaccg gtgaactgcc tttctcaaac gaaatcgtct cggcttcaat 715801 cagcgcgaca tagcgcccgt ttacttttgc gagatgaata gaatcgccaa aatccgctag 715861 caatccctta atctctgttt ctccgacttt cattttcagc tgggcctctg gcgtgtgctc 715921 gatgatttgg gcggaggctt cgatgacttg atgggtgtcg aggcgctctt ggatttcccg 715981 tttttcgctt gcttcccaaa tctcaatgtc gtgctcgaac tgcttgagtt cttcgctgtt 716041 gtcttcaaat gtctcgtaga cgtgctcttg taccatgttc atgacctgat ttttcatgat 716101 ttctggcatc gattctccgt actcgacgaa tttcagaaag tcctcaaaat agcgggcgtg 716161 cgaggcctgg tggattttca gttcaccttc ctcgaccatt ccttcctctg gcatgtacgg 716221 gtattggatg cttttcatgt tttttgtcgt gatcgccatt tcgacttttt taatgagaga 716281 agacgcgtca gagatgcggg cgaccttcgg ctcaaaatca catttcataa tgaagacaaa 716341 tgactcatca aagtattttc tcggcacggc cgaagcgacg agaaacacgc cgccgcgaac 716401 cgcgcttgtg tcaaggtacg tgcggacgaa ctgctcgctc agctcattga agtcttcttt 716461 tgtttccgcc agacgcgcgc ggttgaacat gttgtagttt gggttggaat cgagctcgtg 716521 gccgggctcg acgataaaat ggccgatttt cgtcggcacc tgctcggact gcggatggcg 716581 gtcggctttc cgtttaacga tttttttcag ttccccgtcg agaaagtcct tcagctcgct 716641 ttcttcaaat tctcccgtat caagggtctg gaagtgcttg aactgcttgt tcgcctgctc 716701 atctttgcct tccacctgta tgacataaaa ggataaaaac cgaatttcaa aatccatata 716761 taaactcacc ttattcgcgt attgtacagc ttctcaagta tagaaaaaac agcgatcatg 716821 cgtcaattgg gagaacggaa taatcatgac catgaaaggg aaatgtagtc aaatagaagg 716881 catttcatac ggaaaggaat ggttcgatga aggaaacaag cccgattcct cagccgaaga 716941 cgtttgggcc gctcggcaat ttgcctttaa ttgataaaga caaaccgacg ctttcgctga 717001 tcaaactggc ggaagaacag ggcccgattt ttcaaatcca tacacccgcg ggcacgacca 717061 ttgtagtgtc cggccatgaa ttggtgaaag aggtttgtga tgaagaacgg tttgataaaa 717121 gcattgaagg cgccttggaa aaggttcgcg cattttccgg tgacggattg tttacgagct 717181 ggacgcatga gcctaactgg agaaaagcgc acaacattct gatgccgacg ttcagccagc 717241 gggccatgaa ggactatcat gagaaaatgg tcgatatcgc tgttcagctc attcaaaaat 717301 gggcaaggct caacccgaat gaagcagtcg atgtcccggg agatatgacc cggctgacgc 717361 tcgacaccat tgggctatgc gggtttaact accgctttaa cagttactac agagaaacgc 717421 cccacccgtt tatcaacagc atggtgcggg cgcttgatga agcgatgcat caaatgcagc 717481 ggcttgatgt tcaagataag cttatggtca gaacaaagcg gcaattccgc tatgatattc 717541 aaacgatgtt ttcgttagtc gacagcatta ttgcagagcg cagggcgaat ggagaccagg 717601 atgaaaaaga tttgctcgcc cgcatgctga atgtggaaga tccggaaact ggtgaaaagc 717661 tcgacgacga aaatatccgc tttcagatca tcacgttttt gattgccggc catgaaacaa 717721 cgagcggcct gctttccttt gcgacttact ttttattgaa gcatcctgac aaactgaaaa 717781 aggcgtatga agaggtcgat cgggtgctga cggatgcagc gccgacctat aaacaagtgc 717841 tggagcttac atacatacgg atgattttaa atgaatcact gcgcttatgg ccgacagctc 717901 cggctttcag cctttatcca aaagaagaca cagtcattgg cggaaaattt ccgatcacga 717961 cgaatgacag aatttctgtg ctgattccgc agcttcatcg tgatcgagac gcttggggaa 718021 aggacgcaga agaattccgg ccggaacggt ttgagcatca ggaccaagtg cctcatcatg 718081 cgtacaaacc attcggaaat ggacaacggg cctgtatcgg catgcagttt gcccttcatg 718141 aagccacact tgtgttaggc atgattctaa aatatttcac attgattgat catgagaatt 718201 atgagcttga tatcaaacaa accttaacac ttaagccggg cgattttcac atcagtgttc 718261 aaagccgtca tcaggaagcc attcatgcag acgtccaggc agctgaaaaa gccgcgcctg 718321 atgagcaaaa ggagaaaacg gaagcaaagg gtgcatcggt catcggtctt aacaaccgcc 718381 cgcttctcgt gctgtacggc tcagataccg gcaccgcaga aggcgtcgcc cgggagcttg 718441 ctgatactgc cagtcttcac ggcgtaagga caaagacagc acctctgaac gaccggattg 718501 gaaagctgcc gaaagaggga gcggttgtca ttgtgacctc gtcttataat ggaaagccgc 718561 caagcaatgc cggacaattc gtgcagtggc ttcaagaaat caaaccgggt gagcttgagg 718621 gcgtccatta cgcggtattt ggctgcggcg accacaactg ggcgagcacg tatcaatacg 718681 tgccgagatt cattgatgag cagcttgcgg agaaaggcgc gactcggttt tctgcgcgcg 718741 gggaagggga tgtgagcggt gattttgaag ggcagcttga cgagtggaaa aaaagcatgt 718801 gggcggatgc catcaaagca ttcggacttg agcttaatga aaacgctgat aaggaacgaa 718861 gcacgctgag ccttcagttt gtcagagggc tgggcgagtc tccgctcgct agatcgtacg 718921 aagcctctca cgcatccatt gccgaaaatc gtgaactcca gtccgcagac agcgatcgaa 718981 gcactcgcca tatcgaaatt gcattgccgc cggatgttga atatcaagag ggcgaccatc 719041 ttggcgtatt gccaaaaaac agccaaacca atgtcagccg gattcttcac agattcggtc 719101 tgaagggaac cgaccaagtg acattgtcgg caagcggccg cagtgcgggg catctgccat 719161 tgggccgtcc tgtcagcctg catgatcttc tcagctacag cgtcgaggtg caggaagcag 719221 ccacaagagc gcaaatacgt gaactggcgt catttacagt gtgtccgccg cataggcgcg 719281 aattagaaga actgtcagca gagggtgttt atcaggagca aatattgaaa aaacgaattt 719341 ccatgctgga tctgcttgaa aagtatgaag cgtgtgacat gccgtttgaa cgatttttag 719401 agcttttacg gccgttaaaa ccgagatact attcgatttc aagctctcca agagtgaatc 719461 cgcggcaagc atcgatcaca gtcggtgtcg tgcgcggccc ggcgtggagc ggccgtggcg 719521 aatacagggg tgtggcatca aatgatttag ctgagcgtca agccggtgat gatgtcgtga 719581 tgtttatccg cacaccggaa tcccggtttc agcttccgaa agaccctgaa acgccaatta 719641 ttatggtcgg gccaggcacg ggagtcgcgc catttcgcgg tttccttcaa gcccgcgatg 719701 ttttaaagcg ggagggcaaa acgctcggtg aggctcatct ctattttgga tgcaggaacg 719761 atcgggattt tatttaccga gatgagcttg agcggtttga aaaagacgga atcgtcactg 719821 tccacacagc cttttcccga aaagagggca tgccgaaaac atatgtccag catctcatgg 719881 ctgaccaagc agatacatta atatcaatcc ttgaccgcgg tggcaggctt tatgtatgcg 719941 gtgatggcag caaaatggcc ccggatgtgg aggcggcact tcaaaaagcg tatcaggctg 720001 tccatggaac cggggaacaa gaagcgcaaa actggctgag acatctgcag gataccggta 720061 tgtacgctaa ggatgtctgg gcagggatat agataaagaa gactggagac atccagtctt 720121 tttagtcctt tcgaaaaaat ggtgatcgcg ctaaacattg atgcatacaa taacttcagt 720181 ccgccggaag ggcgggctgt ctgcaaaacc tatttttcgt ttttgctagt ttatgttatt 720241 cttatactcg gtatctattt cttttttcaa aggcacacat gacaaaagaa atcctttttt 720301 tatttccgag aaaaaaatgt gaaacgaaat gaaggtttct ttcgtccagt gattggtttc 720361 caaatggttg taataaaaat gatatggtgc gaaacataaa tattccggct tgccgcggtg 720421 tatttattgt tgtgtgatgc cttgattttg tttggaaaga aggaattgga aggcaggata 720481 taaagagcag gtaaatatga atgaagaact taaagtgttt aagaaagtag aggttgccat 720541 gaagaaactt ttttcttaca aacttagctt ttttgtgctg gctgttatac tgttttgggc 720601 aaaaacgtat ttatcctaca agactgagtt taatcttggg gtaaaaggca caactcagga 720661 gatcctcctg atatttaacc cattctcaag cgccgtcttc tttttaggac tggctttgct 720721 ggcgaaaggg cgtaaatcag ccattattat gctgattatc gatttcttga tgacatttgt 720781 gttatatgca aatattttat tctatcgttt ctttgacgat ttcttgacgt tcccgaacat 720841 taaacagtcc ggaaacgttg gaaacatggg agacgggatt ttcagtatca tggccggtca 720901 tgatattttc tatttcttag atattatcat tttgattgcg gtattgatct ggagacctga 720961 attaaaagaa tacaaaatga aaaaacgctt tgcatcttta gtgatccttt ctgggatcgc 721021 actgtttttc atcaacctgc actatgcgga aaaagaccgt ccgcaactgc tgacaagaac 721081 gtttgaccgc aattatattg tgaaatattt aggtttatac aactacacca tttatgacgg 721141 tgtacagacg gctcaaacag agacgcaaag agcctatgca agcagcgatg atttaacaag 721201 tgtcgagaat tacacgacgt ctcattatgc gaaaccaaac gccgagtact tcggctctgc 721261 caaaggcaaa aatatcatta aaattcacct cgaaagcttc cagtcattcc tgattgacta 721321 caagctaaac ggtgaagagg tgacgccttt cttaaataaa cttgcgcacg gcggggaaga 721381 tgtgacgtat tttgataact tcttccatca gacaggccag ggaaaaacat ctgatgccga 721441 gctgacaatg gataactcga tcttcggtct tcctgaaggc tccgcgtttg tgacgaaagg 721501 cgaaaacacc taccagtcgc ttcctgcgat tttagaccag aaggaaggct atacaagcgc 721561 cgtcctgcat ggtgattaca aatcgttctg gaaccgtgac cagatttaca aacatatcgg 721621 atatgacaag ttcttcgacg caagcacgta tgatatgtca gatgaaaatg tgattaatat 721681 ggggcttaag gataagccgt tctttacaga atcgattcca aagcttgaat ctcttaaaca 721741 gccattttat gcgcatttga ttacattgac aaaccattat ccgtttaacc ttgatgaaaa 721801 agacgcgtct cttaaaaaag cgacaacagg cgataacaca gttgacagct acttccagac 721861 agcgcgttac cttgacgaag cgcttgagca attcttcaag gagctgaagg aagccggcct 721921 gtatgacaac tcagtcatca tgatttacgg tgaccataac ggtatttctg aaaaccataa 721981 ccgagcgatg aaagagattc ttggaaaaga gatcacagat tatcaaaacg cacagaacca 722041 gcgtgtgccg ctgatgatcc gcgttcctgg caaaaaaggc ggagtgaacc atacgtatgg 722101 cggcgaaatt gacgtcatgc cgacacttct gcacttagaa ggaattgatt ctcagaaata 722161 tatcaacttt ggtactgatt tattctctaa agaccacgac gatacggtgg cattcagaaa 722221 cggagacttc gtaacgccga agtacacatc agtcgacaat atcatttacg atacgaagac 722281 aggtgaaaaa ctgaaagcga atgaagaaac gaagaatctg aaaacaagag tgaaccagca 722341 gctgagcctt tcagacagtg tcctgtacaa agacttgctg aggttccata aactaaatga 722401 tttcaaagcc gttgatccgt cagactatca ttacggcaag gagaaagaaa tcaaataaga 722461 tgaaaaagag ccttgagcgg gcgcattgcc ttcgctcaag gctctttttt tggttataca 722521 accaacttga aaaaatagat tccatttggt caccaaggct ggctttctct catatcatta 722581 cagtagattt tgaaaccgga ttgaaatcgg acaaattatc ggggaaatgc cttgatagat 722641 tgtgaagatg taccaggttt cgaactcaat attcatagag atgaggggta gagatgaaag 722701 cggtcattct ctgcggcgga aaaggaacga gaatgagtga agtcacgaat gacattccta 722761 aaccgctcgc catgataggc ggcaaaccga ttctatggca tattatgaaa atttatcagt 722821 actacggagt aaacgagttt attctgcttt tgggctataa aggagaaaaa atcaaggaat 722881 actttctcga ctatgaatgg aagcacaaca gcctgacact cgacagctct acgggagagg 722941 tacagatgct ggggcagcct gaaacgtgga aaattacgtt tttggagact ggggtagata 723001 cgctgacagc cggaagaatc ttgcaggcga aagactatat cggtgatgaa acatttctgc 723061 tcacctatgg agacgggctg gccaatatca atcttttcca tctcatcagc tatcatcaga 723121 caaaaggtgc tgccgcgact gtcaccggca ttgacaaagt ctcgcagttt ggcaccttga 723181 cagttgagga tggcatggcg aaaacatttt ctgagaagac atcaagtgat ggaatcatca 723241 acggcggatt cttcgttctt agtccaaagg ttttcgatta tttgccgaag gacgggaaca 723301 cgatgttcga agatgaaccg ctgaagaacc ttgccaaaga tggggagctt gctgtgtacc 723361 gccattacgg attttggacg gccatcgata cgtataaaaa tctcttagaa gtcaacaaaa 723421 tgtggaatca aggacaacaa gtatggaagg tatggtgaat tgatttgagt ttctggaaaa 723481 ataaaaacgt atttgtcacg ggatgcacag gtcttttagg aagctatttg gtgaaagagc 723541 tgatcgaaca gggcgcaaac gttacggggc tagtcaggga tcatgtgcct caatccaatc 723601 tttatcaggg agaacatatc aagaaaatga acatcgtgcg gggctctctt gaggacttgg 723661 ctgtgattga acgcgcgctt ggcgagtatg agatcgacac agtctttcat cttgctgcac 723721 aagcgattgt cggcgtggca aaccgcaacc cgatttctac ctttgaagcg aatatcctcg 723781 gcacctggaa tattctcgaa gcctgccgca agcatccgtt aattaagcgg gtcattgtcg 723841 cttcaagtga taaagcttac ggcgatcaag aaaaccttcc atacgatgaa aacatgccgc 723901 tgcaaggcaa gcacccgtac gacgtctcaa aaagctgcgc agatctgatc agccacacct 723961 attttcacac gtacgggctt ccggtctgca ttacgcgctg cggaaactta tacggcggcg 724021 gagatttgaa cttcaaccgc atcattcctc agacgattca gcttgtgctg aacggggaag 724081 cgccggaaat ccgaagcgac ggcacatttg tacgggacta cttctatatt gaagacgccg 724141 ttcaggctta tctgcttctt gcagaaaaaa tggaagaaaa caatcttgcc ggagaggcct 724201 ttaacttcag caatgagatc cagctgaccg tacttgaact ggtagagaaa atattaaaga 724261 aaatgaacag taatctgaaa cctaaggtgc tgaatcaggg aagcaatgaa atcaaacatc 724321 aatatttatc cgcggaaaaa gcaagaaagc tgctgaattg gacaccggcc tacactattg 724381 atgagggact tgaaaaaacg attgagtggt atacggaatt cttcaaaaag taatgtgaaa 724441 cgaggtgaac aagactgtga ccagcgcgta ttgcaccgtt ttatcaaaag gaagattata 724501 tcaggcagtc gctttgttta agtcgttaga gcaagttgat caagacagtc ccatttttat 724561 actttgcatg gatgaagata cgcaccgcgt gttacagaag ctgaagatga agcagctgaa 724621 ccttgtgccg gtggccgctc ttgaaaatga attgctgctg aagctgaagg aaactagaga 724681 tcaaagtgag tattgctgga cgatgaagcc gatctttctg caagctgtgc tgaacagcaa 724741 tcctgagctg gagcgtgtga cgtatattga cggggatctc tttttctatg cagatccatc 724801 gccgattttt gaaaaccagc cggactgctc ggtgttgctt tcacgagggg atattgtaat 724861 cccttctttt gagaaagagc agattgacat gctgcagcgt cttttaggca gatataattc 724921 cgggtttatc agcttcaagc atgatgatgc aggcacggat tgcttggagt ggtggaagga 724981 acgctgtctt gaggaatgca aaaatgcacc gggtgaaggg aaattcggtg atcagggcta 725041 tttggattat atgtctgagc tgtttccgaa tgtgtgtgac attacaacac ccggcgtgaa 725101 catcggccat tggaattatg gacagcatac gttttcctgg aaagatggcc ggatcgtgct 725161 ggaggatggc agtccgctga tcttttatca tttcagcgga taccgaatcg tcagcatcaa 725221 tgaaatcaaa cagattcatg aaacaacccg cacagatctg ccgtttgtgc atgaactgta 725281 tcaagagaca ctgccgcata tcattcagca catgcaaacg ttagaccctg aatttaacgg 725341 ttttgcttca aaagatgaca acaaataaat gagtaaatac aggaagtgaa aatgaagtga 725401 aagcaagcgt tattattcct gcatataatt cgaaggagcg tctttacaac agccttctgt 725461 cattaaacca gcaggagtgc gatgaagaat ttgaagtcat tgtagcggac aatggctctg 725521 aggacgggac gctctcgatg cttgagtcat ttcaagctga ttttccgctg atctttacac 725581 ggattaaaga aaacaggggc attgcgtacg gacgaaatca ggcgcttcgc aatgccagag 725641 gagacatcct gattttccat gacagcgata tgcttgcggc aaaggacctt gtggcaaaac 725701 atattaaagc ccatgagaac gaagagaatc tcgtcgtgtg cgggttgttt tggaaacgga 725761 tctacagttt ttactatgaa cgatttgaag aagaacataa ggaacagctc gcaaagctca 725821 caggtgaaat gccgaagaaa gacaaacaaa agctgctgga ggaagcggac atcaaaaacg 725881 gaagctttct tgataaaagc tttgacctcg ataccgactt tatagacgtg ctcaagaaga 725941 ttttagatga gtacggcgat gacttgaaag gctatcatat gccatggcgc ttttttatca 726001 cgaataattc ctctgtgaaa cgcaagcatg tggttgacct cggtttattt gacgaaggca 726061 ttgtgcggta cgggtttgag gattatgacc tcgggatcag gcttcatcag gccggattga 726121 ccttcaggct tcgccgtgat attgtcagtg ttcatcagga acatccaagc aattgtaagt 726181 ctgtagacga tattcgggca aacattgcct atatgtgcga taaatacaat aacatccgct 726241 ccttagacgt tcatctcgct tttaatgggc cgttcccgcc tgacatgacg aacagaatca 726301 tggctgatat tcaaaagctg ctggaatcac agaaatatga tatgctgctg aatctgtttc 726361 ttgagcttct gcatgttgtt aaagagcgca acattgatcc ggattggcga aagaaatccc 726421 caagggtgac ggcgaaaagc tttgatttgc aaactgtccg caagcttctg cctaaggcga 726481 agaaaaagct aggcgtgaac gattttgcca acgcactgta tgcgcttgtc aacgatttgc 726541 tgcacgtgga tcttagatca ttggatgtgg tataagtgag tacatttcat ttttcaacga 726601 tagtgtcaag gacacatatc tttaagctca tgcctatgat tcattctctc catgagcatt 726661 gcgatgattt tcatttatat gtgctgtgtg tcgaccagaa agcgtatgaa ttgcttcagc 726721 acgttccatg ggagcatgta acctttgtgc agctgcatga aatggaagac ccggagctgt 726781 tgaaagcgaa aagcaacaga acgtttcatg aatattgctg gacgttaaag cccgcctttt 726841 tgtttcatgt gatgagcaag tgggatgacg ctgaatactt tgcccatatg gatacggatc 726901 tatttttctt ttctgatccg gcacgtattt ttgcagaaaa cccaacggcg tctctgtatt 726961 tgactgatca tcgtaattcg ccgcgcttca tgtcctacta cgaccgaacc ggacgcttta 727021 atacaggctt tgtcggcgcc ggtaatacaa aggaagcata tgaagcggtg tggcagtgga 727081 gacaggactg tattgaattt tgcacggtcg aaatggatac ggaacgaaag acatatggtg 727141 atcaaagata tgtggagaaa tggccggagc agtttaaagg tgttcatgtt gtcaaatcca 727201 taggagccaa tacagcgctt tggaatatcg aaaactataa ggtcgggcaa aaggacggcc 727261 gcgtgtatat agatgaaacg ccgctgattt tctatcattt ctctgggttt acgctggtga 727321 cagaaaaaga gtttaatctt tgctggtact accggattga agacgaagcg acaattaaga 727381 tgatttatat gccctatata ttaaatctga aaagatggat tgatgaaata cagtcggcgt 727441 ttccggactt tgcggatggc tttatcccga agcacgcagt gcctgacact cattttatcc 727501 agctggatta aaaaaccccc tgccgcctgg caggggtttt ttcagctatg ccattctctc 727561 agcttctggt cacttggcaa taggaaggca aggatgccga ggacagggag aaaggcaatg 727621 gcgatcatcg tcggggtcag tcccgcggca tcaatcagag cgcccagcgc cacagcgccg 727681 attgcgccca tcccgaaggc aagcccgacg gttaaaccgg acattgtgcc gatttttcca 727741 ggaactagct cctgtgcgta gacgaccgtt acagaaaagc tcgacatcag aaccaagcca 727801 atcaatgcga gcacgccgta ggcgagaacc gggccggcaa atggcagcac aatcgccagc 727861 ggcgccgagc ataacagcga accgaggata acgaagcgtt ttccaaaacg gtctgcaagc 727921 gggccgccga gaaacgtgcc gatcgcgccg aacagcaaga agacaaaaat atagctttgt 727981 gcctgctgaa tgcttacgtg ataggtatcc atcgcgtaaa acgtgtaaaa gttaccgatc 728041 gcactcgtat accaagaacg agcaaaaatg agaaatataa taataataag agcagataca 728101 acagatttgg tgatggccgt gttttcagcc gttttctttt gcttgcctga tttctgggca 728161 aggctgccga gacgtgaggc gtaccatttc gcaatataca tgagaaacat aacagcaagc 728221 gcggcgacaa gcgtgaacca aacagcgccg aattgcccga gcggcacaag gatcagcgcg 728281 gtgatcagcg gtgccatcgc ctggcctgag tttccgccca cctgataaat cgattgggcg 728341 agcccgcgtt ttgtgccggc ggccatatac gccacacggg agccctccgg atggaaaatg 728401 gccgagccta atccaatgaa aaacacacag cataagatcg ttatgaatga cggggcaaat 728461 gcaaggccca aaatgccaag catgctggcg gtcaaaccga ctggcagcgc atacggccgc 728521 ggccgtttat cggtatacca gccgacaaca ggctgcatga cggatgacac catgtttaat 728581 gtgaaagcaa tgatgccgag ctgtgtaaac gtcaggctca tggagcgttc caaaataggg 728641 aacatggccg gaatcacagc ctgaagcgaa tcgttgagca tatggcaaat tccgataata 728701 atcaaaatcg gatacaccgt ggtgcctggt ttttgaactg ttttttcttt taacggggcg 728761 gcgatagcca ttgagtctcc tccttacata tataaccaaa gcataccacc atattattca 728821 taaggtgaag aatttatcaa gaggaaaaaa gattcttatg aaagaaatac cgtcagcctg 728881 attagcagct gacggtattt tcgatattca aaatgtgata tagctcttca agcttacgaa 728941 tctcataggt tggtatgatc tctggcacat tcggcttcat gtcagggttc atccagcaag 729001 tatcaagccc ggcgagctgt ccgcctttga tatcagcagt tagtgaatcc ccgatgatta 729061 atgtgtgctc tgctgaaaat tgaggaatcc gttcaaacac gtaattgaaa tattccttca 729121 tcggcttttg gaagccggtg tcttcagaaa cgaaaatgtc cttgaagaat ggaaataatc 729181 ctgaatcacg gagacgctta tattgtgtgt gagacacgcc gtttgtcacg atgtacaaat 729241 caaactgttg ctgcagattt gagatgagat caaatgcacc gtcaataagc tgatgtcctt 729301 cttcaagaaa gcggcggtat ttttgctcaa gcaaagcgcc gtccgcttcg taaccgtact 729361 ccttgagcaa agcggaaaaa cgtgtgttta cgacttcatc ccgtgtcatc ttaccttctt 729421 caaaggctct ccagagacct tgattgatgg ttttatactg cgccttcatg tcatttgtta 729481 aaggaatgtt ctgatcttca aacagcaaac gcagggctaa agcttctgcc gcttgaaaat 729541 caaggatggt atcatctaca tcaaataata aagtgcggta tcgcttcatc tgtgtgtctc 729601 cctttctcat atgtattcaa agtatagcac ataaaaaaag gaaaaagccg gcgggtgagg 729661 caccgccggc tgaaaagaga ttatttgttt aataagctgt gttttctcga atataggaag 729721 taaaccagcg ttccgacagc gatccagatg acaaatgaaa gccatgtgac gccgggaagg 729781 ctgtacatga accaaaggca gatgcctgcg ctgataatcg gcacaaccgg aacgaatggc 729841 actctgaagg acgctttgat ttcaggatgt ttctttctta acacaatgac agcaatggaa 729901 atgaccgtaa acgcggcaag tgttcccatg ttcaccagat gggccagcgt tccgaggtta 729961 ataaagccgg cgattcccgc tgcaacgatc cctgtcagcc atgtgttgcg gaacggggtt 730021 ttaaatgacg gatgaacctt tgcgaacaat ccaggcagaa ggccgtctct gctcatggca 730081 aatgtcaagc ggacctgtgc gtacagcaaa gcgagcatca ccgtcgtaat cccgataatc 730141 gcaccgacag aaataattcc ggcaacagcg tcctgtccga cgaatttcag cgcaaaggat 730201 acaggatctc cgacattcaa tttggcataa ggcatcatgc ctgtcagcac aagcgatacc 730261 gcgatgtaca gaaccgtaca gacggctaga gctgaaataa tgccgacggg catgtttttt 730321 tgcggatttt tcacttcctc tgatgcgtta gaaaccgcgt caaacccaag gtacgcgaag 730381 aatacagtgg cagcgctaag tatgacgcct ttcatcccga atggcataaa aggagaccag 730441 ttatccggtt tcacatagcc gatgccgaca ataatgaaca ataatatgat cgcgattttc 730501 atcagtacga tgacgttgtt aaagcgtgtg ctttccttga cgcctctgct gacaatcgca 730561 gtgatgagga gaatgatcac cgcagccgga aggttaaata cggcgcccgc catgcttccc 730621 ggcgctcctg tcagtgcagc cggaatatga agattgaagc cggcaagcag tgattgaaag 730681 tatgaagacc agccggtggc aaccgccgac agtgcaatga catattcaag catgagatcc 730741 catccgatca aaaaggcgag cagctctcca agtgtcacgt atgagtatga gtacacgctt 730801 cccgaaatcg gaatggaaga cgaaaactca gcataacaga aagcagccag cgcacaggcg 730861 agccccgcta aaataaacga tatgatgagg gcgggacctg caccggtcgc tgccactgtt 730921 cctgtaatga caaaaatccc tgtaccgatg acacaaccga taccgagcaa ggttaaatca 730981 aatgcgctta acgtacgggc aaggcttttt gacttgctct gcgcactcaa tgtttcaagc 731041 ggtttttttc taaataatga actcatcaaa agttcctcct agaaatattc aaaatattct 731101 aatcattata tgcagttctt gttgtattat attgtcgaaa tttgacgtag tcaataaaat 731161 atttttctgc tttaaatgat agaagcgaaa cagcgttgtc gtatcatagg atagtaattt 731221 ttactaatcg tatattcaat tttatgcaag atgaaccgat agaaaaaata gattcgccca 731281 tattttgatt tgcggttata aaggagatgc tgaccatgtt tcaatatgaa gagttgaata 731341 aacagtttat cggcgggaaa tggcaggagg gcagcagccc aaatgtattg gaaaacaaaa 731401 atccttatac tcaaaaaaca ttcacaacat tccgtaaagc gactgctgac gatgtagatg 731461 aagcgtatcg ggcagcggcg ctggcaaaga aaaaatggga tgcggtcaac ccgttcgaga 731521 aaagaaccat tttagaaaaa gccgtcacgt atattgaaga aaatgaagaa gccattattt 731581 atttgattat ggaggagcta ggcggtacaa ggctcaaagc agcttttgaa atcggtcttg 731641 tcaaaaacat cataaaagaa gcggcaacgt tcccaatccg catggagggg aaaattcttc 731701 cgtcaacaat agatggcaag gaaaacagat tatatcgcgt gccggcaggc gttgtcggtg 731761 tcatcagtcc gtttaacttc ccattctttt tatctatgaa atcagtggcg cctgcactcg 731821 gagccggcaa tggcgttgtg ctaaagccgc atgaggaaac gccgatttgc ggcggaacgc 731881 tgattgcgaa aatttttgag aacgcgggaa ttccagcggg gctgctgaat gttgttgtca 731941 cagacattgc tgaaatcggc gacagcttcg ttgagcatcc agtgccgcgg atcatctcat 732001 ttaccggttc tacgaaagtc ggcagctaca tcggacagct tgcgatgaag cattttaaaa 732061 agccgcttct tgagcttggc gggaacagcg ccttcatcgt acttgaggat gcagatatag 732121 aatatgcggt caatgcggcg gtgttcagcc gatttacaca tcaagggcag atttgcatgt 732181 cagccaaccg cgtgcttgtt cattcttcta tttatgacaa gttccttgag ctgtaccagg 732241 caaaagtgga atcgctgaaa gtcggcgacc caatggaccc tgatacgatt atcgggccat 732301 taatcaacag cagacagacg gacgggctga tgaagactgt agagcaagca attgaagaag 732361 gcgctgtacc agtgaagctt ggcggattta acgggacgat cgtggaaccg acgatcttaa 732421 aagacgtcaa accgttcatg agcattgcca aggaagagct gttcggacca gtcgtctcct 732481 ttatgaagtt tgattcagaa gacgaagcgg tggatatcgc aaacgaaacc ccgtttggct 732541 tgagcggtgc cgtacatacg tcaaatcttg agcgcggcgt ggcttttgcg aaacgcattg 732601 aaacaggcat gattcacgtc aatgacacga ccatcaatga tgaaccgaat gtagccttcg 732661 gcggtgaaaa gcaatcaggc ctcggccgtt taaacggtga gtggagcctc gaagaattta 732721 caacgctgaa atggatctcg gtccagcacg aaaaacgcag cttcccttat taatgaaaag 732781 gagtgaatgg aattgaccat aaatacggaa aaagaaaccg cagatattct ggacgcattt 732841 atcaaagtag ccccttattt aaacagcctg gttcaggatg atattacaat cggcatttat 732901 gatacggaaa aactgctcgt gaatataccg gccaaaacct tttcgctgaa cgtaaaagcc 732961 ggcgatccgc tgcaggaagg ggatatcatc acagatgcca tccgcagcaa tcagaagaag 733021 acgagcatgg ttccgaaaga attgttcggc ttcccattga tcgcgcgtgc catcccgctg 733081 cacgacgaga atggaagagt cattggaggc gtcggcctcg gaacgagcct tgaggagtcg 733141 tcaaagctgc atgatgtcgc ggaaagctta tcagctgttg ttgaacaaac agccgcggct 733201 atttccgaca tttctgaatc aattaacggg ttttcaactc aaatgtcggg catttcctct 733261 caggcgaaaa aagtaagcga aagcgccggt gaaatcgccg atatttcagt aactgttaaa 733321 ggcatctcgg accaaagcaa tctgctcggc ttgaacgccg cgatcgaagc ggcaagagca 733381 ggggagtccg gaaaaggatt ctctgtcgtc gcagatgaga tcagaaagct agcgacgcat 733441 tcaaaagaaa atgtcggcca aattgaccag attacgaaaa aaatccacag cctgctgaaa 733501 gggctggagg aatccattga gtcgattaac cagcatacag acggacaagc cgctgctgtt 733561 gaacaaattt ccgccacgat gcaggagatt tcaggaagcg cgcagcatct tgcgaaaatg 733621 gccgaaaaag cgcttgagga agagtaagag accggggaca aacatccccg gtctttttct 733681 tatcctgcat ttccatgaaa ttcgtctgac gttttactag ttttattcca gcggctgatt 733741 taaaatgtac acatgaactt acgtgaggat tgataggaac catgagcata ttaaaagcgg 733801 aaaatcttta taaaacatac ggagataaaa cattatttga ccatatctcc tttcatattg 733861 aagagaatga gagaatcgga ttaatcgggc cgaacggaac aggaaaatca acgctgttga 733921 aagtgattgc cggcttggaa tctatcgaag aaggagaaat cacgaaatcc ggaagcgtgc 733981 aggtcgaatt tcttcatcaa gacccggagc tgcctgcggg gcaaacagtg ctggagcata 734041 tctattccgg tgaatcggct gtgatgaaaa ccttgcgtga atatgaaaaa gcgctgtatg 734101 aactggggaa agatcccgaa aatgaacagc gccagaaaca cctgctggca gcacaagcga 734161 aaatggacgc gaacaatgca tgggatgcaa acaccttggc aaaaaccgta ttgtctaagc 734221 tgggcgtcaa cgacgtaaca aaaccggtca atgagctctc aggcggccag aaaaaacggg 734281 tggccattgc caaaaactta attcagcccg ctgatttgct cattttggac gagccgacaa 734341 accatttgga taatgaaacg attgagtggc ttgaagggta tttaagccaa tatcccggcg 734401 ccgtcatgct ggtgacgcac gatagatatt tcttaaaccg tgtcaccaac cgcatttatg 734461 agcttgaaag aggcagcctc tacacttaca aaggcaacta tgaagtgttt ttagaaaaac 734521 gcgcggaacg ggaagcgcag gctgagcaaa aggaaacgaa gcggcaaaac ctgctgcgcc 734581 gcgaactggc ttggctcaga cgaggagcga aagcccgctc cacaaaacaa aaagcgagaa 734641 ttgaccgggt agagacgctt aaagagcaga caggccctca gtcatcaggt tcactcgatt 734701 ttgccattgg ctcgcaccgt ctcggaaaac aggttattga agcggagaac gtcatgatcg 734761 cttatgacgg ccgcatgctc gtcgaccgtt ttaatgaact tgtcatacca ggtgaacgga 734821 tcgggatcat cgggccgaac ggcatcggga aaacaacgct gttaaatgcc cttgccggcc 734881 gtcatacgcc ggacggaggc gatattacga tcggacagac ggtcagaatc ggctactata 734941 ctcaggatca tagtgaaatg aacggtgagt taaaagtcat tgactatata aaagaaacgg 735001 cggaggtcgt aaaaacggca gatggcgata tgattacagc tgaacaaatg ctcgagcgtt 735061 tcctcttccc gcgttcgatg cagcagacgt atatccgcaa gctgtccggc ggggaaaaac 735121 gccgtttata cttgcttcag gttctcatgc aggagccgaa tgtcctgttt ctcgatgagc 735181 cgacgaacga tttggatact gaaacattaa gcgttcttga ggattatatt gaccagttcc 735241 caggcgtcgt catcaccgta tcccatgacc gctatttcct tgaccgcgtc gtcgaccgtt 735301 tgattgtatt tgaaggaaat ggtgtcattt cccgctttca aggctcctat agcgactata 735361 tggaggagtc aaaagcgaaa aaagcggccc caaaaccggc agctgaggaa aaaacggctg 735421 aagccgagcc gaagaaaaaa cggaaaaagc tttcttacaa agaccagttg gaatgggacg 735481 gcatcgaaga taaaattgcc cagctggaag aaaagcatga acagcttgaa gctgacatcg 735541 ccgcagcagg cagtgatttt ggcaaaatcc aagagctgat ggccgagcag gcgaaaacgg 735601 cggaagagct tgaggctgcg atggaccgct ggacagaatt gtccctcatg atcgaagaac 735661 tggaaagcta aaaagcgtgg ccgcagcagg ccgcgctttt tttcacataa tggacaaaaa 735721 cgaaccggcc tgcttatgtt aggataaagt tgtgtgtcag cggcacatgg aaaactaacg 735781 gagatgatga agtatgacat gggcgatcgt gatgttaatt ctcatgagtc tggtgaaaat 735841 cgtattaacc tgtcttccta caggcgtcat agaatggctg ctcggcaaat ttgaagtgca 735901 cgccaagctg agtgacgaaa atgcgagtct ctctctagat ggaaaacgcc tcgagggtgc 735961 agagaagcag aaagtgattg atcaatttaa cgaagctatc ttcctggaaa aatattatat 736021 ctatccaggt gatgaagagc gttatttaca tccggaaaac ggcggcacgc ctctggtgat 736081 agatacaaaa aaaggaaaaa aagacgtgaa gctgttcgtg taccgctacg acgaccatat 736141 cgacgtcgtg aaacagtaca agaagaaagt gatcgcgtat cgagtgcttt ctgaaagcct 736201 tcaaaaagag tctctgtcag tggcgggaag tttagcttaa acaggaaagt gaaagacggg 736261 tgctgtatgc tgctcgtctt ttttattgtt ttttaaaact taacgtttac gttaaggttc 736321 aaaaggtgta taatggtaac agaaacggcg aagggggatt taccttggaa tggatgaaga 736381 ttgatcaagt ggccaaaaga agcgggctga caaagcggac catccggttt tatgaagaaa 736441 tcggcttgat tccggcgccg aaacggacag acggcggtgt aaggctttat tcagaggatg 736501 atatggagga gcttgagaaa gtcatcagca caaaagaggt gctcggtttt tcccttcagg 736561 agcttcagca tttcatggaa accagccgcc agctagagtt aaacaaagag gggtatttgt 736621 tgtcactgga tcctaaggaa cggaaagaaa aactggagga aattcaggaa accctgaatc 736681 accagctgga tttgattgat gagaaaatcc gcacattcca aagctttaaa gaacgcctgc 736741 agggcatgaa aggcaaagcg gaacgcgcca ttcaatcaat cgaatgaaaa gtttgttaaa 736801 cgctattttt gtagcgtttc ttttaatgga ataaagatgg aggttaggtc aaatggataa 736861 gacaacacaa gtgaatcaga aaacgggttt gctcagccag ccaaaagcgg tatgggctgt 736921 cgcgtttgcc tgtgtgattt cttttatggg aatcgggctg gtcgatccaa ttcttccggc 736981 cattgccgca caattgcatg cttcacctag tgaagtatca ctcttgttta caagttattt 737041 gcttgtaacc ggatttatga tgtttttctc aggagccatt tccagccgca tcggcgcgaa 737101 atggacatta attctcggac ttatttttat tattgtgttt gcggggcttg gcggcagctc 737161 aagctcaatc gctcagttag tcggctatcg cggcggctgg ggattaggga atgctttgtt 737221 tatttcaaca gcgcttgcgg tcatcgttgg cgtgtcagtc ggcggcagcg cccaagcgat 737281 tattttgtat gaggccgcgc tcggtctcgg gatttctgtc gggccgcttg caggcggaga 737341 gctcggaagc atttcatggc gcgcaccgtt ttttggagta tctgtcctga tgtttattgc 737401 gttaatcgcg atttctttca tgcttccgaa gctgccgaaa ccggcgaaac gcgtcggtgt 737461 gtttgatgcg atgaaggcac tcaaatataa aggcctgctg acaatggcgg tatcggcatt 737521 cctatacaac tttggatttt ttattttgct agcttattct ccgttcgtac tggatttaga 737581 tgaacacggt cttggatatg tcttcttcgg ctggggcctt ctgctggcga ttacgtcagt 737641 ctttacggcg ccgctcgtgc acaaagcgct gggcacagtg cgttcgctag tcgttctctt 737701 tatcgccttt gcggccattc tcgttattat ggggatctgg acagaccatc agactttgat 737761 tattacatgt atcgttgtcg ctggtgctgt cctcggtatg gtgaatacga tcatgacaac 737821 cgctgtgatg ggttctgcgc cggttgaacg ttcaatcgcg tcttcagcct acagctcagt 737881 ccgcttcatc ggcggcgcgc tcgccccgtg gattgcagga atgctgtcag aacactttac 737941 tgcaagcaca ccatatacag taggcggaat cgtcgttttt gtcggcatgc ttgtccttct 738001 catgggacgt aaacatcttg ctggaattaa ggcggggcat taataacgaa agacactgcg 738061 catatgcagt gtctttttat tcgttataat gcatcataat cgaattggtg caggaaagga 738121 caacctttat gacacaattt tactattttc cggctgaaaa ctccctttag aaaccggttt 738181 tttcggtcag caagaacggc gttcgcggaa agggcatccg cttcggtcag gcattgatgc 738241 ggctgggatt tatcttgcag aagctgagaa tgtgtccgtt catttacgat tgccatttca 738301 gtgatggttc atgctgtaga ggggacgttt gccatggata aggcaaaacc tgacgaatat 738361 gatcagaaat gtttagaaac gctctatcaa tacatacaca gcgtcatgaa aaacagcttt 738421 tctcggtcga gtggtttacc gcttgggaag atgaggagga ttttgagctg tctgccaaaa 738481 gagagctgac acttgatgaa ttcacatctc cattgcagct cattttaaaa gacagagagc 738541 ttttgagaat cgttcagaaa aaatggcagt aaaaaacccg ccctttagca ggcgggtttt 738601 tttataaatt aaagcacttt cgtcgtccaa gactcgcagt tccacgtttc tgtcgcaata 738661 tccatataaa agtctggctc gtgggaaatg agcagaatgg agcctttata ttctttcagg 738721 gcgcgcttga gctcttcctt ggcatcggca tccaagtggt ttgtcggctc atcgagcacc 738781 agcaggtttg tttctgagtt gattagcttg cacaatctga ctttcgcttt ttcgcctccg 738841 cttaatacgg agacgcggct ttcgatatgc tttgtcgtca gcccgcattt tgccagagcg 738901 gcacggattt catactgcgt ataagaaggg aattcgctcc atacttcttc gatgcacgta 738961 ttgttgtttg tttccttgac ctcttgctcg aaatagccgg tatagatgtg ctcaccgcgt 739021 tcaacagagc cttcgagcgg ctggatttca ccaagcaaac ttttcagcaa tgtcgttttt 739081 ccgatcccat tcgcgccgta aagggcgatt ttttggccgc gctccatgcg gaggttgagc 739141 ggacgggaca gcggggaatc gtaaccgatc acgagatcct tcgtttcaaa aatcagcttg 739201 cctgacgttc tcgccggctt aaagtggaat tccggctttg gcttttctgc cgcaagctcg 739261 atcatatcca tcttatcgag tttcttttgg cgggacatcg ccatgtttct cgtgctgaca 739321 cgcgctttgt tgcgggcgac gaaatccttc agctccgcga cttcctgctg ctgctttttg 739381 taggccgctt caagctgctg ttttttcacc tcgtagactt ccataaactg atggtagtcg 739441 ccgacataac gtgtcagctc ttgattttca acgtgataaa tcaggttgat gacactattc 739501 aagaacggaa tatcgtggga aatcaggatg aacgcgttct cgtattcctg caggtagcgt 739561 ttcagccatt caatatgctg ttcatcaaga tagttggtcg gctcatcgag aagcagaatt 739621 tccggctttt caaggagaag cttagcgaga aggacctttg tgcgctgtcc gccgctcaaa 739681 tcggtgacat ctcgctctaa accgatatcg ctcaaaccga gaccgcgggc gatttcttcc 739741 accttggaat caatgacata aaaatcattg tttgtcagcg cgtcttgaat gacgccgact 739801 tcttcaagca gcttctcgag ctcgtcggga tcagcctcgc ccattttgtt gtaaatctcg 739861 ttcatttcct cttccatcgc aaataaataa tggaatgcgt ctttcaggac gtcgcgaatg 739921 gattttcctt tttccagcac ggtatgctga tcaaggtatc cgacacggac attttttgac 739981 cattcgactt ttccctcatc aggttcaagc tttccggtaa taatattcat gaaggttgat 740041 tttccttcac cgtttgcgcc gatcaagccg acgtgctcgc cttttaacag gcggaaggaa 740101 acgttattaa aaatggcccg gtccccgaaa ccgtggctta aatcctttac agataaaata 740161 ctcatgttta cacctctatc gttatcaaac acgcacaatc ggcgtgtaat attcaccctt 740221 ttgattataa aggaggattc ggaatgttga aaggtatagg aaagaaaaag aaaaattgcg 740281 ttccgggcga ggttttgaga tactatggaa tagatttcag gaattgagga gaacaaaatg 740341 acgcaaactt ggccattttt acataatgca caatcattta tacaagagaa ttggaatgct 740401 tccggctttc aaaagccaac ccctgttcag gagcaggcag cccagctgat catggacgga 740461 aaggatgtca ttgcagaatc gccgacaggc acagggaaga cgctggcgta tgcgctgccg 740521 gtcttggagc ggatcaaacc agagcaaaag catccgcagg cggtgatttt agcgccttcc 740581 cgtgagctgg tcatgcagat ttttcaggtg attcaggatt ggaaagcggg ctcagagctg 740641 cgcgcggctt ccttaatcgg cggggcgaat gtgaagaaac aggtcgaaaa gctgaagaaa 740701 catccgcata tcatcgtcgg cacgccaggc agggtgtttg aactgattaa agcgaagaaa 740761 ctcaaaatgc atgaagtgaa aacgatcgtg cttgatgaaa cggatcagct cgtcctgccg 740821 gagcatcgcg aaacgatgaa gcaaatcatt aaaacaacat taagagaccg ccagcttcta 740881 tgtttttctg ccacgctcaa aaaggaaaca gaggacgtgc tccgcgaatt ggcgcaagag 740941 cctgaggtgt tgaaggtgca gcgaagcaag gcggaggcag ggaaagtgaa gcatcaatac 741001 ctgatttgcg accagcgcga caaagtgaag ctgctgcaaa agctgtcaag gcttgaaggc 741061 atgcaggcac tcgtatttgt gagagacatt ggcaacctga gtgtatatgc ggaaaaactg 741121 gcatatcacc acgttgaact cggcgttttg cacagtgaag cgaaaaaaat ggagcgagcg 741181 aaaatcattg ccacattcga agacggagag tttcctcttt tattggcgac tgacattgcc 741241 gcacgcggtt tagatattga aaacctgcca tacgtgattc atgctgatat tccagatgaa 741301 gatggctatg tccacagatc aggacgaaca ggccgggccg gaaaagaagg caacgtgctg 741361 agccttgtga caaaattgga ggaatctaag ctgaaaaaaa tggcgaagaa gcttggtgtt 741421 gagctgagtg aagctgtgta tgcaggcgga aaactgaaga cgaaataaaa agaagggcga 741481 agagcccttt ttttgttgta aaataataga aaagattttg cgcggaggtg ggaaaatggc 741541 ttcaatagac aggtttcaag taatgcagga gccagagctg aaaatccttg aacactggtt 741601 tgagaatgag gataccagac ggagaatgga tgggatgctg ctattagatg agtggtatgc 741661 acgagtaaat aaagataaac acgatactgt catcatggcg tatgatggac agctgccggc 741721 agggatggtc gttattgagt tcggagagga gcggacatat attggattga tcgtcaatcc 741781 tttgtaccgg cttaaagggt atggaaaaca gatactgcaa aagctgatga ccgaacctga 741841 ttttactagc gtgcgagaat gggtggcatg cattgaagaa gacaatcgaa tcagtttagc 741901 ttgctttcaa gcagcaggat tcactttaga agacacggaa cctgatgaag atggttttct 741961 tacgctgatt cttcgcaact gatctcatcg aaacacaaaa ggagggcaaa aagccctccc 742021 gttttcatct tcattcagct cggatcactg accttgatca gctgtttccc tttattttct 742081 cccttaaata aaccgagaaa cgcgtcagga atgttttcga agccttctgt gatggtttcc 742141 tcgtaatgga gtttaccagc cttcagccat tctgccagct gttttgctcc ctcagaaaaa 742201 cgatcggagt agtcgcttac gataaagcct tgcatcagcg acttcgtttt aatgagtttt 742261 gattggacac gagggcccat gtcatctgct tcgctttctg cgttatagga agaaatggcg 742321 ccgcacaccg gaatgcgggc aaattcattg agcagattca tcaccgcgtc tgaaatcggt 742381 ccgccgacat tgtcaaaata cacatcgaca ccgtcaggac aagcgttttg aagcgctttt 742441 tggatatcat ccgctgtttt gtaattgatg gcttcgtcaa actgaagctc ctgttttaaa 742501 tagtcgattt tttcatcaga gcccgcgatg ccgacgactc gcgcgccttt gattttggca 742561 atttgcccga ctgttgaacc gacggctccg gcagctcctg agacaaccac ggtttcgcct 742621 tccttcgggc gtccgatgtc cagcaatccg aagtatgctg ttaagccggt cattcccaaa 742681 atgccgagat aggccgaagc gggagcaagg cttgtatcaa tttttcgcaa ggcagactcg 742741 ctcacagcgg aaaattcctg ccagctgaga tttccgatga cgatatcgcc ttttttcaga 742801 tgattcccgt ctgacacaac ttcagcgata acccctccag aaagcgcttt atccaaggcg 742861 aacggctcaa catatgactt cgtatcctgc atacggccgc gcatataagg gtcaaccgat 742921 acataaagcg ttttgacaag cacttcccct tgcttgggtt caggaaccgg aatggtttca 742981 aagcgaaagt cttcatgaac aggaatacct tgtggacgtc ttgctaattg aatttgctgc 743041 tgagatgctg tcattttcat cctcctatca cttggttgac accactgtaa catggacagg 743101 agaggaaata caaaaggtaa gctggcatac aaaaaaggtt atagatgagc ttatgctttc 743161 tacaagctct tttgttttaa aagttctctt tagtcattta tcattattag aaaacagaac 743221 agaaaaagag ctcctgtaca cctagctaag attggctagt gtgtatgtcg attctttttc 743281 atattcttgc aagcatctgc gagggggagc ttagtcgttc acattttgct ttcgcatcaa 743341 tctgcaatag caaagtctat gcgatttttt tacatcagca aagatttgtt caattttttc 743401 cttttatgcc gagtttttct gaaacagata attgatggta ctcaaccatt ttcttttggt 743461 caataaagta atgtttactt attaattaaa cacgcgaaaa agcaaacgaa aacataatta 743521 aattttatat atttattaaa agcttatatg tttatttacc ttttttttga attgtaattg 743581 agaaaatcca tatattgcgg acactaataa aagaatacct gctgaaacat aaactaaacg 743641 aactccaagg aaatctgaaa tagcccctat agccagaatt gaaaacataa aaatgaactg 743701 tactaaagaa gaccttgcag acattatatt aattcgagtt tgctcggttg ttatgttctg 743761 aataagtgtt tcttgtgtaa gatctcttaa tatataagcc ggccccataa agagaaccaa 743821 aattagagct aagtatgaat tacttataaa accatatatt aaagttaaac ttccatatga 743881 gacagcgcca attaacataa aattaattaa cttattttga aatctctccg acagcttata 743941 tattataaat ccccctatca tcgaacctaa ataatatgct ccattaataa atccccacca 744001 tgattctcct ttatgcaaga cttcgttaac gaaagctaaa gagacagatc ctatccaaat 744061 cattcctgcc catgactcaa ttaaatccat aataataatt gttctaagtt tcttttggct 744121 aaataaatac cgccaaccac ttactatact cttattggga gaattttttt cacgtatgac 744181 agaattagcg tggccatgtg gtagacaaaa taaaagagaa agaagagatg taaacaacaa 744241 aaagatagta agtataatgg tatatccctc acctaaaaat gcaattatga gaccacctaa 744301 agaccagcct acaaattgaa aagtttggtc cactgtagat aataatccat ttgcttttac 744361 tcttctatca ggagagatta tttcccctat aattgcactt tttaaaggtg agaaccatcc 744421 attaaaaaag gaaatacagc taataataat aaagactaaa atgagagttt gattagagta 744481 agttcttaat aaagcataga acaaacatat taataacagc atttgtatca attgagaaat 744541 aattattgta agaggcagtt ttaatcgaat tgttattaac ggtaatatag cacttccaaa 744601 aatacgaaaa ataatactta ttaatgtcac catagaggcg atggttgtcg aattggtcat 744661 tttaaacaaa aacgaaatca ctaccatagt atatagagaa aaacctaaat ttgtagtggt 744721 ctggctaaat aaaatagaat aataaccttt actcatatgt atcctccctt ggaataattt 744781 ttctcggtaa agagcttaaa catatttaaa caccttaaaa caacaaaagt aaagaaaaaa 744841 tttccttgta aactatttac ttttattcta tttattgtta ttgtttattt aagttctctg 744901 actattctat caatattcag ggaaccacat atcttattaa aggggggaaa accatgagaa 744961 aattaagaaa aaactggaga aaatcgattg ttagcccggt tctttatact aatgaaaaat 745021 ggtaaacact tagggaatag catttaatgc tattccttat ttcaacaaac aaatcgggag 745081 gttatcgtaa tttgactcta ttaatgcaag atcataaatc aatttacaat aaagatatag 745141 aaatattaat tgaagttgaa gaacttatta cttctgttcc agaaaataaa aaaaatgatt 745201 ttaagagttt aatcgataat agaattatga ctctactaaa taaaattcaa caccctgtag 745261 cagcggaaaa tgtgtttggg atgtgtattg cttatccgaa tacttacata aggtatagat 745321 taattgattt cgttgaaaaa tgggtacctt atttctctgc tgtagaaact ataatcaatc 745381 taacccagga tccggatgat ttagtttctt ttaaagctat ggatgtctgt gcaaatcata 745441 aaattgaaga atctgtagca tatttgtctt cgattattga tgatgtccgg gagagtataa 745501 gctaccctaa aaaacctgtg ggattagggg cccaaaaagt attaagtaca ttattagata 745561 tattcggtgt tgaaaaacat gaagagctag taatgctaaa aaattatttt gatcaaaatg 745621 gtatacttcc taataacttt gactttgaag aaaaaattcc tcaaagtcta atagaggaat 745681 tcgaaaaaac agaagaagat gggatgattt taattccggg tggctttttt gaattcggtt 745741 taaatgaaaa tgaaattcct gacaaaacat ttaattggaa agatgctgtt cctagacaaa 745801 aagtatggtt acctccattt tttatcgata agtatcctgt tacaaataaa gattatgata 745861 tctttaccga gttcatagag gaaaatgggc atatattctg tcatcctaat gaaccgcaga 745921 ataaacaaca tagaagaaat acatattggg atgataggta tttagataat catcccgtta 745981 caggtataga tttttatgat gcatttgctt acgcaagata taaggggaaa gaattgccaa 746041 ccgagtttca atgggaaaaa gctgctcgag gcgaaaaggg taatgtctgg ccttggggag 746101 ataaatttga tcctgcaaag gttcaatatg ctggaagtct ttataatgaa cccattactt 746161 ctttaaagtc ctggagagaa aatttattaa aagctcatgc tgataaagaa ttaaatcatt 746221 taacaagtga tatttttgaa caaaatggtg aaagtcccta tggagtatgc ggtatgatcg 746281 gcggaacatg ggagtggact agaagtgagc ttaaaacaaa gagagctttc caccctattt 746341 ttgagaatgt accatttaat agtgttaact catttgccgt tcttaaagga ggatcattct 746401 tctctcatcc aggcttaatg ttcccttctt ttagagcaaa agatattcct ttctgtcgac 746461 acaatgaaat ggggattaga tgcgtaaaga atattccagt atataaaatt agagaatcaa 746521 ttaatgggcc aattactaat aaagcaattt attaatcatt ctaggttaga gacttgataa 746581 aagtatacta acattgtgta gtaatgttca gcttgtagaa aaaacaatgt tttttctaca 746641 agattttatt ttaaatgctt ttcaaaatta tcagggattg agaatcagaa aaagagccat 746701 taagctcgat cttagctagg tattacgatc ttctgtatat tattgtgaga aatatagaag 746761 attcagttag ttagcatttc gattttaagc tgagcctgca atagcaaagc atctgttttg 746821 attattcttt ttctgataca taagctaatt ttgtcgcttt tcttttttgt cttttcacgc 746881 atttcgagga tgacttacta taattctttc agcttttcta tgtgttaaga ttcgaataga 746941 tgaaataact ttaacaagtt ggtcaataag aacagattta actttatgtt aaaagagtat 747001 ctcgtataga acataagaag aatgacgagt tttttaagat tatcatcaat tatgtgagaa 747061 taaaatatta taagggaaaa tgaaggctgt cacgtttctc gacagcccta gggaattcct 747121 ctccttttca tttcgcccgt aatttcgggc acagtcccgt cggcaggcac attggcttct 747181 ggtcgatcgg gcttctcatg atgcagcatt ccaagccgaa gacttcacgg aaaaatggct 747241 gggtgaacac atcttccggt gttccggcgt tgtatatttt tccgtccagc acactgatca 747301 gatagtcagc atattgagcg gcttggttta aatcatggag caccatgaca acggtgcggc 747361 catggtcgcg gttcagcttt ttcagcagtt caagcacttc aatctgatgt gagatgtcta 747421 aatacgtggt cggctcatca agcaaaagca aatcagtgcc ttgcgcaagt gccatggaaa 747481 tccaggctct ttgtctttgg ccgcctgaga gggcatcaag tgtccgatcc ttcagttcaa 747541 tcatgcccgt tgcttccagc gcccactcta ccatgtcatg atcctcttgg gtatgcttgg 747601 ataacagctt tttgtgagga tgtctgccaa aatagcataa ttcctctacc gtcaatcctt 747661 caggagcctg aggagattgt ggaagaatgg ccagtttttt tgcgacttct tttgatggct 747721 ggcggtggat gtcttttcct tctagtagca ctgtaccgct ttttggggcc atcagcctgg 747781 cgagcgattt gaggattgtt gatttaccgc agccattagc gccgatgagc gcagtgattt 747841 ttccttcttc tatctttaag tcgactccgt caataatcac tgtactgtca tatgaaagag 747901 tgagctggtc tgcagccagt tttcccatgg tatcctctcc ctactgtttc ctcgcttcga 747961 atttcaataa atataagaaa taaggcgcgc cgatcacggc tgtcagtatt ccggcaggta 748021 tttcaaccgg aggcatgatg ccgcgcccta acgtatctgc aattaataat ataatagcac 748081 caatcaatgc cgatgcaggc agtaaatatt tagctttttc tccggtaagc cgtctggcga 748141 tatgcggagc aagcaagccg ataaaaccga ttgagccgac gacggctaca cagcttcccg 748201 ccagcgccac cgcggtgaaa atcaggatga atctcagccg gtttgcgttt tctccgagac 748261 cctgtgcaag ctcatccccg agtgacataa gatccagctt cggtatgagt atgcagacga 748321 tcggaaaaag aatcaaaagc catggcgcaa gcagcttgac ttcttcccag tttcttcccc 748381 agaggcttcc tgtcagccaa atgagtgcag cattcacgtc gcctggaaac ttgaccatca 748441 tatattgcat tccggcgtgg cagaccgcgc ctaaagcaat gcctgataaa gccagtgaag 748501 agggctgaat gctctttttt cgggctatca ttaataatag tacagcaata atggcggctc 748561 cggcaaatgc ggagaacgga agcacgtata ccggcgactc aggaaagatg agaatcacag 748621 ccatcgccgc aagtccggag ccttttgaaa tgccgacaac gtccggggaa gcgagcggat 748681 ttcggatcac accctgtaaa atcgctccgg cagcggcaag tccagcacct gccaaaatcg 748741 ctaatataat gcggggaagg cgatattgct ggatgataaa ttcaaaggaa tgatccagtc 748801 ccagcagatt cgtcactacc gcatcaggtg aaatgtataa tgcaccgatt ccaatgctga 748861 tgacggacag aacgattaaa atcacggcca atatgagtat cgccagtaag gggcgttttt 748921 gttttctggt tgttttcttc atttcaggtt tcgccctttc cttgccaaat ataagaaaaa 748981 cggcgttccg ataatcgcgg tgacaatgcc gaccggtgat tcataaggaa atgcaatcca 749041 tctggccaga acatctgcgt acaccagcaa aatggcaccg aacagtgccg aaaacggaag 749101 cacgtattga taatgttctc cgatcagctt gcggacaata tgcgggacga gcagcccgac 749161 aaagccaatc ggcccggcga cggctacgga agcgccggaa agaattaaaa taatcaaact 749221 gatcagaatc ctgatgccgt tcatattttg tccaagccct tttgctgttt cgtctccgag 749281 accgagaaca gaaacagaac cggaaaatac gagggcaagc ccgatgccaa tgacagaaaa 749341 aggagcgatg gttatgacgt cctgccagtt gctgccgtcg attgcgcctg tcatccagta 749401 cagaacatcc tcacctgact catttaaaat aatgatggcc tgtgtcatag aggagaggaa 749461 caagtgcacg gccattcctg acagcgccag cttgacaggc gtcattccgc cggatgaggc 749521 aatcatatac acaatcgcgc cgcctgctgc cgcacccgca aaagcgaata taacagatga 749581 atagggcgat gccggcagaa tgacgagaga agcaacaaca aaaagcgatg cacccgcatt 749641 cacaccgaaa atttggggtg aagccagagg atttctggtc atagcctgca tcagcgcccc 749701 tgctacagct aggctggcgc cgacaaaaac gccgattaat gtgcggggaa ggcgaagagt 749761 agagatgatg agctgttcct ttgaaccgtc ccatacaaaa agatatttca atgaatctat 749821 gatgctgatg tctgaggctc ctactgaaag attcagccca agcccaaata taaaaataat 749881 cagtgcaatg ataaacatca tcagtcttga tgatgagcgc cgtttggctg aatgatacaa 749941 cagtctcact tccttactgc gtctggttgc aaaaacgaag aagcaaggat tcccctcgct 750001 tctcatttgt cctatttatt atacactttt ttaagcacat ctttggcgct tgtttcacta 750061 gacttgatgc ctctgaatct tgtccaagtg tcacggtccg catcatagac ttgtccattt 750121 ttcaccgctt tgagattttt ccagagcggg ttcgttttcc actcatctac aatggttttg 750181 ccttcgttgg ctgagatgaa caaaatatca ggatcgattt tgctcaattg ctcaaggctg 750241 acctcttgat aggcgttatc tgacttcaca gcgtgtgtaa agcctagcat tttaaagatt 750301 tctccgtcat aggatgatga tgtatgaagc tggaaggaat ccgctcttgc aacgccgaga 750361 acgatgttgc ggttttcatc tttcggaagt tcggctttta gatcgttgat gacttttttg 750421 tgctcggcaa gcttttcttt tccttcatct tctttattta atgctttagc aatggtcgta 750481 aagctgtcga tcgtttcgtc atatgtcgct tcacggcttt ttaattcaat cgtcggggcg 750541 atttttttca gctgtttata aatgttttta tggcgctcag cgtcagcgat gattaaatca 750601 ggcttcaagg aactgatgac ctcaagattg ggttcgctgc gtgtgcctac agatgtgtaa 750661 tcaatggagc tgccgacaag ctttttaatc atatcttttt tgttgtcatc tgcgatgccc 750721 accggcgtaa tgccgagatt gtgaacggca tccaagaatg aaagctcaag cacaaccacc 750781 cgcttaggtg tgccgcttac tgtcgttttt ccttcttcgt catggatcac tctggaatcc 750841 ttagactcgc ttttgccgct tccgttgtta ttctggcttg atgaacagcc ggatacaatg 750901 aggcaggcga gcaataaaac actcatgatg gcaatcaact tgttagaata ggtgcgcatg 750961 tcattcttcc ttttttcaga tttagtaatg agaatcatta tcacatgtaa cactataata 751021 gcatggctta tcatgtcaat atttttttag taaagaaagc tgcgttttta ctgctttctc 751081 atgaaagcat catcagacac aaataagtgg tatgcagcgt taccgtgtct tcgagacaaa 751141 aacgcatggg cgttggcttt agaggtttcg aacatatcag cagtgacata aggaaggaga 751201 gtgctgagat aaccggacaa tttcttttct atttcatctg ttagtgcaaa ttcaatgtcg 751261 ccgatattca tgataatcga gaaaacaaag tcgatatcga tatgaaaatg ttcctcggca 751321 aaaaccgcaa gctcgtgaat tcctggtgaa catccggcac gcttatggaa aatctgtttg 751381 actaaatcac tcacaatcca agcattgtat tgctgttctg gtgaaaagta ttgcattaga 751441 catacctcct gctcgtacgg ataaaggcag cgtttcatgg tcgtgtgctc cgtgcagcgg 751501 cttctcctta attttgattt ttctgaaaat aggtcccgtt cctatcactt taccatggac 751561 ggaaaacaaa tagctactac cattcctcct gtttttctct tcaatgttct ggaatctgtt 751621 tcaggtacag acgatcgggt atgaaagaaa tatagaaaac atgaaggagg aatatcgaca 751681 tgaaaccagt tgtaaaagag tatacaaatg acgaacagct catgaaagat gtagaggaat 751741 tgcagaaaat gggtgttgcg aaagaggatg tatacgtctt agctcacgac gatgacagaa 751801 cggaacgcct ggctgacaac acgaacgcca acacgatcgg agccaaagaa acaggtttca 751861 agcacgcggt gggaaatatc ttcaataaaa aaggagacga gctccgcaat aaaattcacg 751921 aaatcggttt ttctgaagat gaagccgctc aatttgaaaa acgcttagat gaaggaaaag 751981 tgcttctctt tgtgacagat aacgaaaaag tgaaagcttg ggcataaagc aaggaaaaaa 752041 ccaaaaggcc aatgtcggcc ttttggtttt tttgcggtct ttgcggtggg attttgcaga 752101 atgccgcaat aggatagcgg aacattttcg gttctgaatg tccctcaatt tgctattata 752161 tttttgtgat aaattggaat aaaatctcac aaaatagaaa atgggggtac atagtggatg 752221 aaaaaagtga tgttagctac ggctttgttt ttaggattga ctccagctgg cgcgaacgca 752281 gctgatttag gccaccagac gttgggatcc aatgatggct ggggcgcgta ctcgaccggc 752341 acgacaggcg gatcaaaagc atcctcctca aatgtgtata ccgtcagcaa cagaaaccag 752401 cttgtctcgg cattagggaa ggaaacgaac acaacgccaa aaatcattta tatcaaggga 752461 acgattgaca tgaacgtgga tgacaatctg aagccgcttg gcctaaatga ctataaagat 752521 ccggagtatg atttggacaa atatttgaaa gcctatgatc ctagcacatg gggcaaaaaa 752581 gagccgtcgg gaacacaaga agaagcgaga gcacgctctc agaaaaacca aaaagcacgg 752641 gtcatggtgg atatccctgc aaacacgacg atcgtcggtt cagggactaa cgctaaagtc 752701 gtgggaggaa acttccaaat caagagtgat aacgtcatta ttcgcaacat tgaattccag 752761 gatgcctatg actattttcc gcaatgggat ccgactgacg gaagctcagg gaactggaac 752821 tcacaatacg acaacatcac gataaacggc ggcacacaca tctggattga tcactgtaca 752881 tttaatgacg gttcgcgtcc ggacagcaca tcaccgaaat attatggaag aaaatatcag 752941 caccatgacg gccaaacgga tgcttccaac ggtgctaact atatcacgat gtcctacaac 753001 tattatcacg atcatgataa aagctccatt ttcggatcaa gtgacagcaa aacctccgat 753061 gacggcaaat taaaaattac gctgcatcat aaccgctata aaaatattgt ccagcgcgcg 753121 ccgagagtcc gcttcgggca agtgcacgta tacaacaact attatgaagg aagcacaagc 753181 tcttcaagtt atccttttag ctatgcatgg ggaatcggaa agtcatctaa aatctatgcc 753241 caaaacaatg tcattgacgt accgggactg tcagctgcta aaacgatcag cgtattcagc 753301 gggggaacgg ctttatatga ctccggcacg ttgctgaacg gcacacagat caacgcatcg 753361 gctgcaaacg ggctgagctc ttctgtcggc tggacgccgt ctctgcatgg atcgattgat 753421 gcttctgcta atgtgaaatc aaatgttata aatcaagcgg gtgcgggtaa attaaattaa 753481 gaaagtgaaa aacacaaagg gtgctaacct ttgtgttttt taattaatta aaatgtttat 753541 taacttagtt aaggagtaga atggaaaagg ggatcggaaa acaagtatat aggaggagac 753601 ctatttatgg cttcagaaaa agacgcagga aaacagtcag cagtaaagct tgttccattg 753661 cttattactg tcgctgtggg actaatcatc tggtttattc ccgctccgtc cggacttgaa 753721 cctaaagctt ggcatttgtt tgcgattttt gtcgcaacaa ttatcggctt tatctccaag 753781 cccttgccaa tgggtgcaat tgcaattttt gcattggcgg ttactgcact aactggaaca 753841 ctatcaattg aggatacatt aagcggattc gggaataaga ccatttggct tatcgttatc 753901 gcattcttta tttcccgggg atttatcaaa accggtctcg gtgcgagaat ttcgtatgta 753961 ttcgttcaga aattcggaaa aaaaaccctt ggactttctt attcactgct attcagtgat 754021 ttaatacttt cacctgctat tccaagtaat acggcgcgtg caggaggcat tatatttcct 754081 attatcagat cattatccga aacattcgga tcaagcccgg caaatggaac agagagaaaa 754141 atcggtgcat tcttattaaa aaccggtttt caggggaatc tgatcacatc tgctatgttc 754201 ctgacagcga tggcggcgaa cccgctgatt gccaagctgg cccatgatgt cgcaggggtg 754261 gacttaacat ggacaagctg ggcaattgcc gcgattgtac cgggacttgt aagcttaatc 754321 atcacgccgc ttgtgattta caaactgtat ccgccggaaa tcaaagaaac accggatgcg 754381 gcgaaaatcg caacagaaaa actgaaagaa atgggaccgt tcaaaaaatc ggagctttcc 754441 atggttatcg tgtttctttt ggtgcttgtg ctgtggattt ttggcggcag cttcaacatc 754501 gacgctacca caaccgcatt gatcggtttg gccgttctct tattatcaca agttctgact 754561 tgggatgata tcaagaaaga acagggcgct tgggatacgc tcacttggtt tgcggcgctt 754621 gtcatgctcg ccaacttctt gaatgaatta ggcatggtgt cttggttcag taatgccatg 754681 aaatcatccg tatcagggtt ctcttggatt gtggcattca tcattttaat tgttgtgtat 754741 tattactctc actatttctt tgcaagtgcg acagcccaca tcagtgcgat gtattcagca 754801 tttttggctg tcgtcgtggc agcgggcgca ccgccgcttt tagcagcgct gagcctcgcg 754861 ttcatcagca acctgttcgg gtcaacgact cactacggtt ctggagcggc tccggtcttc 754921 ttcggagcag gctacatccc gcaaggcaaa tggtggtcca tcggatttat cctgtcgatt 754981 gttcatatca tcgtatggct tgtgatcggc ggattatggt ggaaagtact aggaatatgg 755041 tagaaagaaa aaggcagacg cggtctgcct ttttttattt tcactccttc gtaagaaaat 755101 ggattttgaa aaatgagaaa attccctgtg aaaaatggta tgatctaggt agaaaggacg 755161 gctggtgctg tggtgaaaaa gcggttccat ttttccctgc aaacaaaaat aatggggctg 755221 attgcggctc tgctggtctt tgtcattggt gtgctgacca ttacgttagc cgttcagcat 755281 acacagggag aacggagaca ggcagagcag ctggcggttc aaacggcgag aaccatttcc 755341 tatatgccgc cggttaaaga gctcattgag agaaaagacg gacatgcggc tcagacgcaa 755401 gaggtcattg aacaaatgaa agaacagact ggtgcgtttg ccatttatgt tttgaacgaa 755461 aaaggagaca ttcgcagcgc ctctggaaaa agcggattaa agaaactgga gcgcagcaga 755521 gaaattttgt ttggcggttc gcatgtttct gaaacaaaag cggatggacg aagagtgatc 755581 agagggagcg cgccgattat aaaagaacag aagggataca gccaagtgat cggcagcgtg 755641 tctgttgatt ttctgcaaac ggagacagag caaagcatca aaaagcattt gagaaatttg 755701 agtgtgattg ctgtgcttgt actgctgctc ggatttattg gcgccgccgt gctggcgaaa 755761 agcatcagaa aggatacgct cgggcttgaa ccgcatgaga tcgcggctct atatcgtgag 755821 aggaacgcaa tgcttttcgc gattcgagaa gggattattg ccaccaatcg tgaaggcgtc 755881 gtcaccatga tgaacgtatc ggcggccgag atgctgaagc tgcccgagcc tgtgatccat 755941 cttcctatag atgacgtcat gccgggagca gggctgatgt ctgtgcttga aaaaggagaa 756001 atgctgccga accaggaagt aagcgtcaac gatcaagtgt ttattatcaa tacgaaagtg 756061 atgaatcaag gcgggcaggc gtatgggatt gtcgtcagct tcagggagaa aacagagctg 756121 aagaagctga tcgacacatt gacagaggtt cgcaaatatt cagaggatct cagggcgcag 756181 actcatgaat tttcaaataa gctttatgcg attttagggc tgcttgagct tggggagtat 756241 gatgaagcca ttgatctgat taaagaggaa tatgcgatac aaaatgaaca gcatgatctt 756301 ttattccata acatccattc gcagcaggtg caggccattt tgttagggaa aataagcaag 756361 gcatcggaaa agaaggtcaa gctggtgatt gatgagaaca gctcactcgc gcctcttcct 756421 gcgcatatcg gcttgtccca tcttattacg attattggca atttaattga taacgctttc 756481 gaagctgtag cggagcaaag cgtgaaggaa gttttgtttt ttatcacgga tatgggccat 756541 gacattgtca ttgaagtatc agacacaggg cccggtgtgc cgccagagaa aatagaagct 756601 gtgtttgaga gaggctattc ttcaaagggg atgaggagag gctacggtct ggccaatgtg 756661 aaagactcag tgcgtgaact gggcggctgg atcgaactgg cgaatcaaaa aactggcggg 756721 gcggtattca ctgtatttat accgaaggag aaacaaaggg ggaatccatt tgattcacat 756781 cgcgattgcg gaggatgatt ttcgagttgc gcaaatccat gagagattga ttaaacagct 756841 tgatggattc aagattatcg gcaaggcggc taacgcaaaa gagacattgg cgcttttgaa 756901 ggaacacaag gctgatttgc ttctgctgga tatttatatg ccggacgagc ttgggaccgc 756961 gttgattcct gatatacgaa gccgatttcc tgaagtggac attatgatta tcacagcggc 757021 aacagaaacc cgtcatttgc aggaagcgct aagggcggga attgcccact atttgatcaa 757081 acccgtaaca gctgacaagt tcaggcaggt gctgcttcag tataaagaaa aaaggaagct 757141 gctcatgtct cagccggagg tcagccaatc catgatcgac catatttttg ggaacggtgt 757201 gaagacagct ttgccggcag aggatttgcc gactggcatt aattcgatta cactgcgaaa 757261 aattaaggaa gcgcttcaga ctgcgtcaga aggattgaca gcggaggaac ttggggaaaa 757321 aatgggggcg tcacgaacaa ctgcccgccg ttatgccgag taccttgtgt caaaggaaga 757381 agcaagagcc gagcttgaat acgggattat cggcaggccg gagagaaaat attatttggc 757441 ggcggattag atatgaaaaa atctataatc ctattgaata ttctattgat ctttatgcag 757501 ggtgatatca ggcaggcggc tgcgccgcgc ctgccggacg ggccgataga aattgtcgtc 757561 cctgccgaac cttctggcgg ctgggatgtc acagcgcagg cgatccaatc agttttgagg 757621 cagaagcaga tcgtgaagga tgatgttcat atcgtctata aatccggcgg cgggggagag 757681 aaaggctgga aatatgtcaa caaaagcagc aaacaaacca tcagcatgac gtccagccta 757741 atattgagca atgatcttct cgggcaaagc aaattaaaaa tgtccgattt tacgccgctc 757801 gccattctct ccaaggaatg gcagacggtt gcattgccaa aaggatcagc gttaacaaat 757861 ggcaaggatg tgctgaatga gatcaacatg catcccggca aggtgagaat cggctttgcc 757921 ccggggtttg gcaatgatga tcagctctcg ttcgtcagag cggcagatat gtacggcatt 757981 gacccgtttg acattcaatt ctcacagtat gacagcagcg aacagctcat tcaggcgctg 758041 atcagacatg agatagaagc ggcttccatg acactttctg aagcgaaacc atatgaacga 758101 aacggcgata tcacgttagc cgctgtaacg tctgataaaa gacttcccgg ttttccaaat 758161 gtaccgacgt ggaaggagca gggaatcccg tttgtttttt ctcattggag agggattttg 758221 ggcccgaaaa atatgtctga ggaagagatt tcttactggg atcaagcgct aaagaaggtc 758281 acctcctcac ctgaatggaa gcggaaaata aacgaacagg actgggaaag cttttattta 758341 aacagcaggg aaacgaaacg gtttttagaa gagcaatctg ctttttatca aagcatcatg 758401 acaggaaatt aaaatcccga catcccggga tttttttcat gccgaaaatt gatcaaaaag 758461 aacaaaacgg ttttaaaaaa ttaaaaatac aaaaaaacca aattatttac ttgcggttgg 758521 ttttcccata cgatggcaaa aaggcaagac aaaaagggga gtaagggaga aaaaaatgta 758581 agcggattca tttaaggggg aatggatgtg ttagcaatct taggctttct catgatgctt 758641 gtgtttatgg cattgatcat gacaaaacgg ctttctgttt taacagcatt agttttgacg 758701 ccgattgtgt ttgcgcttat cgccggattt ggatttactg aagttgggga catgatgatt 758761 tcggggattc agcaagtcgc gccgactgcg gtcatgatta tgtttgcgat cttatatttt 758821 ggaattatga ttgatacagg cctgtttgat ccaatggttg gcaaaatttt aagcatggtc 758881 aaaggagacc ctttaaaaat tgttgtcggg acagcggttc ttacaatgct cgtcgccttg 758941 gacggagatg gctcgacaac gtacatgatt acgacaagcg ccatgcttcc gctctatttg 759001 ctgctaggca tccggccaat tatcttggca ggaatcgcgg gagtcggcat gggaatcatg 759061 aacacgattc catggggagg tgcgacgccg agggcggcga gtgcgctggg ggttgatcca 759121 gctgagctta cagggccgat gattcctgtc attgcaagcg ggatgctttg tatggtggca 759181 gttgcgtatg tgcttggaaa agcggaacga aagcgccttg gtgtgattga actgaaacag 759241 ccagccaatg ccaatgaacc ggctgctgcg gttgaagatg agtggaagcg gccgaagctt 759301 tggtggttca atttattgtt aacgctttct ttaataggat gtttagtatc gggtaaagtc 759361 agtttaaccg tactgtttgt cattgcgttt tgtattgcgc tgattgtgaa ttatcccaat 759421 ctcgagcatc agagacagcg catcgcggcg cattccagca acgtgctggc tatcggttca 759481 atgatttttg ctgcgggggt gttcacgggg attttgacag gcacgaaaat ggttgatgaa 759541 atggcgatct cgctcgtgtc catgataccg gaacaaatgg gcggattgat cccggcgatt 759601 gttgccttaa caagcggcat tttcacattt ttgatgccga atgacgcgta tttctacggg 759661 gtgctgccga ttttatcaga aacagctgtc gcatacggtg tggataaagt ggaaattgcc 759721 agagcctcta ttatcggcca gccgattcat atgctgagtc cgcttgtgcc atccactcat 759781 ttgcttgtcg gactcgtcgg agtttctatt gatgaccatc aaaaattcgc attgaaatgg 759841 gcggttctcg cagtgatcgt catgacggct atcgctctat tgatcggtgc gatctctatt 759901 tccgtatgat aattcaggcg taatgacaca cactaacggc atacaacatt ccggaggtgt 759961 cattatgagt gatccttata tgccgctgac ttcagtcaga agcggagcgg ggttcgaagc 760021 ggcaaaaggg gtgcacggcc tgactgtgca aattgcgaat gtctatttta ttcagctgcc 760081 ttctgaacct cactcatttg ttttaattga tgccggcatg ccccaatcag ccggcgtgat 760141 tgtcaatgaa gccaaacaaa gattcggtga agggtttcag ctgaaggcga ttatcctcac 760201 acacgggcac tttgaccata ttggggcaat cgaagagatc cttgagcatt gggatgtgcc 760261 tgtttatatc cattctcggg aaatgcctta tgtaacaggt aaagaggatt atcctccggc 760321 tcgtcctgac agcaagagcg ggctggtcgc taagctgtcg ccgctgtttc cgcggcactc 760381 tatcgatatt tcctcacatg tccaggcact gccggaagac ggttcagttc cttttcttga 760441 cgagtggatg tggatcgcga caccaggaca cacgccgggc catatttcgt tattccgcga 760501 tgacggccgc gtgcttgtgg caggtgatgc tgttattaca gtggaacagg agaaaatggc 760561 tgacgtcttg atacaaaaac aggagcttca cgggccgccg gcttatttca cgcctgacac 760621 agagacggcc gctgagtcca ttctaaagct ggccggtctt gaaccggaag cgttattgac 760681 cgggcacggc ataccgatga ccggcaaaaa ctttcgaagt gacttaactg aattggcaaa 760741 tcggttatcg tctatttgac acccgcacca cgcgggtgtt ttttattgtt ttccaggaag 760801 ttgcagaaaa atcatttgtc ttgccgctta aaaacgatac aatgaaaagc atgaagtgat 760861 gtgaagggga gagtttgttg gaagaaaaag aaatactctg gaacgaagcg aaagcgttta 760921 ttgccgcatg ctatcaggaa ttgggaaagg aggaggaagt gaaagaccgt ctcgcggaca 760981 ttaaaagtga aattgacctg accggaagct atgtacatac gaaggaagag ctggagcacg 761041 gagcgaaaat ggcttggaga aacagcaacc gctgcatcgg cagattgttc tggaattcgc 761101 tgaatgttat cgacagacga gacgtccgga cgaaggagga agtgcgtgat gccctctttc 761161 accatattga aaccgccacc aataacggga aaatcagacc gaccattacg attttccctc 761221 cggaagagaa gggtgaaaag caagtcgaga tctggaatca tcagctgatc cggtacgctg 761281 gatatgagtc agacggagaa agaatcggcg acccggcttc ctgttccctg acagcagcct 761341 gcgaagagct cggctggcgc ggagagcgaa cggattttga cctgctgccg ctcatttttc 761401 gcatgaaagg ggacgagcag cctgtctggt atgagctgcc gcgttcactt gtgattgagg 761461 ttccaatcac acatccggac atcgaggcgt tttctgattt ggagctgaag tggtacggcg 761521 tgcctattat ttctgatatg aagcttgagg tcgggggcat tcattataat gccgcgccat 761581 ttaacggctg gtatatgggc acggagatcg gagcgagaaa cctcgcagat gaaaagcggt 761641 acgacaagct caaaaaagta gcgtccgtga tcggcatcgc cgctgattac aatacggatt 761701 tatggaagga tcaagcgcta gttgaattga ataaagctgt gctgcactcg tataaaaagc 761761 agggtgtcag catcgttgac catcatacag cggcaagcca gtttaaacgg tttgaagaac 761821 aggaggaaga agcgggcaga aagctgacgg gggactggac gtggctgatt ccgccaattt 761881 cacccgctgc cactcatatc ttccaccgct cctatgataa ctcaatcgtt aagccgaact 761941 atttttatca agataagcct tatgagtaaa caatagaaaa tcgatgatgg ccttcaaggc 762001 tgcgggattc agtcacagag atgtcggtaa cctttgagaa agggcttccg ttctttacag 762061 cctcaacaaa cgattgcagg gcgttttccg gaccctctgc caaaatctcg acacgcccgt 762121 catcacggtt tttgacccag ccggccagtt ttcgcttatc agcttccatt tgaacaaaat 762181 agcgaaagcc cacaccttga acccggccgt ctacaatgat tcggtattga agcatgtaaa 762241 aaccaccttt tctttttatg ataatcaatc attttacaac ctgtaaaggg gatgtgtttg 762301 tatgaaacaa gagcgctatt cagttctttc tcttaatctg ggaaaaccgc agacgcttga 762361 atatgacgga aagaaaatcg aaaccggcat catgaagcgg ccggctaaat cagccgtcat 762421 gctgtatcgg gagaattttg aaggagacgg acaggcggac ctcgtcaacc acggcggacc 762481 tgataaggct gtctgtgtct acccggcgga gcattatccg ttttgggaag agttcctctc 762541 aagaccgctg tcaaatgccg catttggaga aaatctgacg gtcgcgggcc tgactgagga 762601 gaatgtttgc atcggggatg tgttcagact tgatgaagct gttgttcagg tcagccagcc 762661 gcgccagccg tgtgtaaagc tggcgaaaaa gtttggtgta aaagaaatgg tgctgaaggt 762721 ccagcaaacc ggctatacag ggttttattt tcgcgtgctg gaggagggca gggtgtctcc 762781 cggcgcgaac cttgaattgc tgtccagagg agagaaaggc atatccgtcc agttcgcgaa 762841 ccgcatcaac taccatgatg caaaaaatct caccgccatt gaacggattt taagtgaggc 762901 tgcactatcg gaaagctgga gagcgtcctt tatgaaaaaa aaggacaggc tgctgccggt 762961 tgaatagaaa aaagccgcgc atatcaacgt gcgcggcttt gccatattta agattgtttt 763021 ttctttgatt caagcaggtt ggcaagaaaa taggttttat agctttgaag ctttcttcct 763081 tcatggtgcg tgatcccctg cttttttagt tctgccacat accagccttt actgccgtaa 763141 tgcatgtcag aaaactcctt tccctatctg atttcgaaac gattggcatt gtaacatcta 763201 taaaaagatg ctgaaaagag atgcggggaa aactgagcct ttcgcactag atgtacgaat 763261 gttcttctga atgtatatgc ggagcaaaag ccgaatatga tttaatggcc ggttagtttg 763321 atcatgacaa cgccaaatgt cataatggcg aaaacaatgc cgatatatgt gagcatcccg 763381 ttttttttct taacgccgta aacggtcata atgatgcctt caatgaaaaa aatgatgccg 763441 aaaataataa accacatgca gataaaggct cctttcacag acataatagt agtgtagcat 763501 atctgaaaga gccgggctgt gacaatatca agaaagccgg gcgcatatcg cccggctcat 763561 gttttattgt ttatcaacca atttgaccag aagctgtgcc aaatgttctt tctcatcttc 763621 gtctgcaacg ctccaaagct cttgcagcag catttcttca ccgttttgcg gctcttcatg 763681 ctttgcgagg tagtctccca ggatcgcagc gctttttaca agcttgccgt catccaatcc 763741 cagctttttg cctcggttga cttgtttttt caggtagcct ttaaattcct caaagtcttt 763801 taaaatgtct tcttttattg tgccatgcat cgcgttcatt tcgttttcaa tttggatttt 763861 ttcttgatct ctgttcattg caagacctcc tcgtacagaa taatgatgct ttacctgcaa 763921 ttggaggagg ttaaacctgc cggaagcccg gaatgtgttt tacagtttcg tcaggataat 763981 cggttcatct tttgtgatga cgatcgtgtg ttcaacttgg gcaaccatgc ttttatccgg 764041 cgtcttgaac gtccagccgt ctccagcttc aacaatcgtt tctgctttcg ttgaaataaa 764101 cggttcaagc gcgatgactg tgccattttt gaacagcgca ttatcaaacg gatcataata 764161 gttcatgatg tggttcggcg cttcatgcag gcttcggccg attccgtggc cggtcagggt 764221 tttgatgacg gtaaagcctt gagagcgtgc ttcatgataa acggctcttc cgatctggtt 764281 ttggcgcttg cccgcttttg cctgctgaag ccccttttga aaagcgtttt ccgcgcattg 764341 gcaaagctta tgaaggcgtt cttctccttc accgagcaca aatgagatgc ctgtgtcgga 764401 atagaagccg ccaaattcag cggagatgtc gatgttgaca aggtcccctg cttttaaaat 764461 tttggatgtg cttggtatgc cgtgagccac ttcatcattt acgctgatac atgtcacacc 764521 tggaaaatcg tattccttct caggagctga aacggcgccg tgctcatcaa gcacagcttt 764581 tccgataagg tcaaggtctt ttgtgctcat gccgggctct gccttccgct tcatttcttc 764641 acgcgcaagc gcgacgattc ttccgatttt tttcaggcct tctaattctt gatcgtttgt 764701 tacaatcatc tgtcattccc gctttctttt taaataatct agattaagct taccacaact 764761 gtcttaaaaa taggaaacac acggacctgg gaaaaaagaa atacccccgg gaaaattggt 764821 atagatcact agatatctta tatggtatat ttgaaaaaaa agggtatgag ggggatgggt 764881 atgctttcat ttttacaaaa actcgggaag tcatttatgc tcccgattgc ggttctgcct 764941 gcggttggaa ttatccttgc gcttggcaga gaggatgtat ttaatatccc gtttgtctat 765001 caggcgggga cggcggtttt tgatcatctg ccgcttattt ttgcgatcgg tattgccatc 765061 ggcatttcaa aagacagcaa tggggcagcg ggtttatcag gggcgatatc gtatctgatg 765121 cttgacgcgg caacaaagac aattgataaa acaaataaca tggcggtgtt tgggggaatt 765181 attgccggtt taattgccgg ttacacctat aaccgcttca aggataccaa gctgcctgaa 765241 tatctcgggt tcttcagtgg cagacggctt gtgccgattt taacagccat tattacgatc 765301 attttagcgg gcatattcgg agtggtctgg ccgccgattc aatcgtgtat caactcgttt 765361 ggagagtgga tgctcgggct cggcggcatc ggggcaggca tattcggcct attcaacagg 765421 ctgttaattc cgcttggcct tcaccatgtg ctgaacaata ttttctggtt ccaattcgga 765481 gaatataacg gagtgacagg ggatttggcg cgctttttcg cgaaagatcc gactgcgggc 765541 acatatatga ccggattttt cccaatcatg atgttcggtc ttccggcggc gtgtctggct 765601 atggttgtga ctgcgaagcc gtctaaacgg aaagcgacgg ctggaatgat gattggattt 765661 gctttaacgg cgtttatcac agggattacg gagccgattg agtttgcatt tatgttttta 765721 tctccgcttt tatacgctgt tcacgcggtc ttaaccgggt tatctttatt tatcgtcaac 765781 tggctcggca tccgctcagg cttctctttt tcagccggag ctatcgatta tgtgctcagc 765841 tatggaatcg cggaaaaacc gctgcttctg cttttggtag gtatatgcta tgcggcagta 765901 tactttatcg tgttttatgt actgattaag gctttgaatt taaaaacgcc tggacgggaa 765961 gacgatgatg tggatgaagt gctggatgaa aatactgttc aggatgtaaa tgaaaacatc 766021 atgctgaaag ggctcggcgg aaaagaaaac cttcaaacca ttgatcattg cgccacaagg 766081 ctgcgactga ctgtgaagga taccgctttg gtggatgaag cactgctaaa gaaagcaggc 766141 gcaaaagggg ttgtcaaatc gggcgggcaa tcggttcaag tcattattgg cccgaatgtg 766201 gaatttgcag ctgaggaatt gagggctgct gtcaaataaa aaagcggaga gggcaacctc 766261 tccgcttttt cttatttatc ttcgttatcc tttgacgttt cggaagaatc ttcgtcatgt 766321 tttgtgtaat cataatcaga aggattcacc ttcttaaaac ctttcggctc gtagaaccgc 766381 agcaggtctc cgtttatgat tttatcggac atttcaagtt ccttcttgac gagtgagtct 766441 tctgacttgt cgacttcgga ttcatcgagt tcttttccgg ttttcgtgtc gtaatactta 766501 ccggatattt tcgtgtactt cggtgaaata aagtctccgt ttcggaacgg aatcacttca 766561 cggtgttctt tcgataaaat atcagaaccg gacatcagat agtccttcgt atccactccg 766621 agcagatgca gaatggtagg agccacatca acgtctccgg catatttatg aactttctcg 766681 cccttcacgc cggcagcgtg gataaagagc ggcacccgtt gaagctgggc gttgtcgtaa 766741 tcagtgattt catccttgcc aagcactttc gccatcgctt tattgtggtt ttcagagatg 766801 ccgtagtggt ctccgtacat cacaataatc gatttatcat ataacccgtc ttttttcaga 766861 tcattgaaga attgttcaat ggactgatca aggtaatggg ctgactggaa atagttatcg 766921 acgacagagt caccaaagtc tccagccggg aagtctgtat ccccctcatc cattccgaat 766981 gggaagtggt tggaaagggt aatgaacttc gtatagaacg gctgcggcag gctttccagc 767041 agcggcattg attctttgaa gaacggtttg tctttcatgc cgtagttttt cgtgttttct 767101 tcgttcatgt catagtaagc agaatcaaag aatttatcaa tgccttccgc cttgtacatt 767161 tcgttacggt tccagaacgt ctgcgtgttc ccgtggaaag tagcagatgt gtaattctta 767221 gacttcagaa tcgccggaac ggattgcagc gtgttttgcg ctttgtttac gaaaactgaa 767281 ccttgagcca gcgggtacag agagttttcc atcataaatt cagcatcaga tgttttacct 767341 tgtcccgttt ggtggaaaaa gttatcaaag tagaacgttt cgttatcatg tgccagttta 767401 tttaagaatg gtgtcacttc tttgccgtca attttatagt cgatgataaa tgactgcaaa 767461 gattcaagtg aaacgtaaat gacgtttttt ccttccgctt tgccgaaata cacgttattc 767521 ggcacatcgt aattggcttt catgtagttt tctacttccg ttacgtcgct ggaatcggca 767581 agcgcgcgct ggctgttgga cttgatattc tgtacagcgt cataaatcgt gaaattgtat 767641 gttcccaagt atttcacaag atagttccgg tcgaatgatc ttgtcagcaa ttcaggacgg 767701 tctgattccg caactgccag gttgatcaag aacacaagaa ttgaagacgc aaaaataatt 767761 cggaacgatt ttttgcttga cgtttcggca ggcttgttta ctttgatcgc caagatgatc 767821 aggatgatcg tatcgataaa gtaaaaggcg tcagtcggtc tcatcagcga aaatgcgctg 767881 tcaccgagtt ggccgccgtt tgttttagcc tgcataatga ccggaattgt aataaaatca 767941 ttgaaaaatc tgtagtacac aatgttggcg tacagtaaaa aagacattaa aaaatgaatc 768001 actataatgg ctgtctgctg taattttttc ttgaacaaga gtccaaagcc aagaaagaac 768061 aagcttgagc taagaggatt cacaaaaagc aatatttttt gtatcgtgtt gtctattcct 768121 aagttgaaat tcaggacata accgacatac gttttgatcc ataacaggac gaccgcaatt 768181 aagaagaagg ccagtcctct ttcttttata aatgttttca ttgttacact ccttttttcc 768241 gatccagttc gagcgaaacg atagaaaaaa cgaacgtatc caatataaca cgaatcagca 768301 gattagaaaa gtgaaaatcg tatgagggag aaagtggcga aaaacgccgt cgaatcaacg 768361 tttcgctttg atattaccaa atgtaaaaca aggtatcttt ctagaaataa aggaataaaa 768421 tggtacattg agaattgtat gataaaatat aaggtataga taaaaagagg tgaaatgatg 768481 gatttttccc atattgtgtc tgaagataaa attaagcgcg ccatcaaaga cggggacttt 768541 caaaacctcc cgggaatggg gaagccgctg ccgaaggatg acgcggcaca cttgccggaa 768601 tcgctgcgca tgggctatcg tattttgaaa aacgcgggaa tggcagagga cgagggcgcg 768661 ctcaaaaaag agcttatgac catcgaccat ttaatcgaaa agtgctatga cgaaaaagaa 768721 cgcgagcaat taatcagaaa aaaatctgaa aagcaattgc tgcttgataa gcttgtcgac 768781 aaaaaaggca tgttttcaaa gccagcatcc gctttttata agaataaagt atatgaccgg 768841 cttggacgaa acagaccttc ttccagctga tttgtcttgt ctgcaggatg gcgattgata 768901 aaagccatcc tttttatgtt ccaagttcta tgtcaaaagg tttatgtttt tccatctatg 768961 ggaaatgatt cataaacgaa aaaagggtga tgggatggaa cgactattag tatggataga 769021 gcatatatct gattggctgt ggggtccgcc gctaatcatc ctgctgacgg ggacgggctt 769081 gtatttcact attttgctga aaggttttca atttcgctat cctttataca ttttcaaaca 769141 gacaatcggc agtgtaggaa aaaagccgaa gggagaaggc acagtcacac cgcttcaggc 769201 attgacctca gccctcagtt caacgatcgg tgcagcgaac attgtcggtg tgcccgccgc 769261 tattatgttt gggggaccag gagcggtttt ttggatgtgg cttattgcct tatttgccat 769321 ggcgattaag ttttctgaaa gtgttcttgc tgttcattac agagaaaaaa atgagcaggg 769381 tgaatacgtc gggggaccga tgtattacat aacaaaaggg ctgcgcatga aatggctcgg 769441 cgtattcttc tctgttgcgc tgattgtgga gctgattccc agcattatgg ttcagggaaa 769501 ttcggtttca gtctcgcttg ccgagacgtt ttctttcaat aaaatatacg caggaatcgg 769561 aattgcattt ttgattgggt tagtggtgat aggaggggta aagcggatcg gaaaagtaac 769621 agagtttgtc gtgcctctta tggcaggggc atacgcaggt gccggtctcc tgattgttct 769681 catgaatcta tcatcagtgc cggcgttttt ctctctcgtt ttttcaaatg cgtttacctc 769741 ttcttcagca gttggagggt tcgcaggtgc tgcgttggcg gaaaccgttc gctggggatt 769801 tgcccgcggg ctgtattcta atgaagccgg gatgggaaca gccccgattg cacatgcggc 769861 agcaatgact gatcatcctg tgcggcaagg gttttggtct gtgatcggca ttgtcattga 769921 caccttaatc atctgtacga ctaccgcttt tatcgtcctt gcatccggtg tatggacagg 769981 gaagaacgcc tcaaatgacc cggcagcact gacaacggcc gcatttcagc actatttcgg 770041 ttctggagga ggatacttcg tttcggtttc cctggtcttc tttgtcgtat caaccattat 770101 ggttgtcatt ttttacggcg taaagcaagc tgaatttctg ttcgggcggc tggcaggaca 770161 tgtgattaaa ttcgtttatt tagcggctat tatcataggt gccgcaggcg gagcaaaagc 770221 catttggggc gtattggact tagcattggt ttttattgtt gtcccgaatg tgattgcgct 770281 cttgttattg agcagaaagg taaaagcgct gtacaccgaa ttctttacat ctgaacagta 770341 ctacctgaaa gatataagaa aaacgaaaca aaagcctgtt tatccaacaa aagaagctaa 770401 aaattcctag tgttttgctt ttgcgccgaa caatgctttg ctttttatga tcaaataaat 770461 gagtaaaggc agcaaaagag aaatcactac attaatgatt ggtttgattc tgttaaagtc 770521 gattagctga tttgtattta aaaaaaacca aaagccgcat acgactgaga acatgccggt 770581 tggtgtatac atggctttcg ggtcgatttt tgagtgtaaa aacgaaaggc cgtataccac 770641 gatatatagg gaacctgcta tcttcaccat aatgaccgga atccaaaaag ccgcgatgat 770701 caggtctgag cgatccagaa aatccgtaat gcggatctgc ctgatgacca tataagcagg 770761 atcaaagaaa gtagatgtca ggttgggacc aaagacagaa attgaagaaa ataacatcac 770821 ggccagcaat aaagcgccca gcagtatcgc gaaaatggtg tattttagcg ggacgctccg 770881 gtttgagaag agaagcggaa ggataatcaa ttcccccatt gtcccaaacg cgtaatagcc 770941 tgattgaagg tatgggatta gaccttcaaa aacaggtgtc aagttttgaa gctcaatttg 771001 tgtggccagc gtaaatggaa ggaacaagac caggatgccg aatggaaata ggaatatctg 771061 cgccattctg gtcaatgttt cttttccctc tctggcaata cagatcgcca caaagataat 771121 aacaccgcca agaacagcca ttggtgttct cgggagaaat aaaatgttaa tcaaattgat 771181 gaaaaaacgt atatcatgag cattgattaa caggaaatac aaagaaaaca gtaaaatgat 771241 aatccggcct gcgattggtg aggaatcgct cagcagctca tagatatttt tatcctgatg 771301 ctttttcatc agcctatgca tgagccagag tgccggaatc acgatgacaa cgccgaggat 771361 gtagctgtgc caggcatttt gttttgctga ttcgatcatg agaatcggag catgctttaa 771421 tccgactgct aacgtataca gagctccgaa aaataatcct tggtatgcag aggtcttgtc 771481 cataaagcac atcctttctg tcatgttcaa aacggaatat atttaaacag gtgccccagc 771541 cgcggaagca ggggattcac tctcatataa atccatagaa aagcacttcc tgcaattagc 771601 aggctgaagg cccattttgt tagattgtta gcggaacgaa aattcttcca ttcatatgcg 771661 tatatggcaa tgcacacaat caatgtctgt acgatatagc tgatcatgct gacgcacctc 771721 cattaatggc tgatcgtttt gtataggaca ccgccctgct caatcgtcac aattgggacg 771781 acgtgaacct ccatatcctt atatacctct tcccattcct ttttcagcag attcttcgtg 771841 gttgccgtgc ttctgatggt cctgtcttga aagccggccg ggtccgcctt tagcttttgc 771901 aaacgatgaa cggtgctgat cacgtccttc tttatggttc tgtttaatgc tttttgaatg 771961 atgtaatact ggtcattttc tctcgtctca taggttgatt ggttttccat aataattcct 772021 ttggctctga tctcgattgt cattgacagc tttccgtttt tttcagcggc atgaaaggat 772081 gcattggact tttgaagctg aatggatgct tgccccattt gattcggcag gtctactatg 772141 aattctggct ggcgggcttg attcagcaac atcagggctg ctgtcatgtg ttcatctttg 772201 aaaatatcca tcaatctgtc ctttttaaag atcgcaagcc cgtcaatttt caaattagat 772261 ttgcctttcc ctccaggttt tgttttagat gcagagatga ccggtgcata cggatcactg 772321 cctatttcta ctagatcaga catgaatctg cttaagaaaa cggggcggct cgttgcgata 772381 atggccagct cccgaatcat ttccgccgga aactgttcaa gctgaacatc ggtatttaaa 772441 atgtcccgcg cttctccccg gctgactaaa atgagcgccg ttaatctgtt ctgcggattt 772501 cgcgttaaaa tatcaaagac tggggcaacg ccgtctctcg ccatatcctc tccaataatg 772561 actgtacgtc tgtgggacgt attgattgtc cgtgacaagg aggtttgcag cttgttgttc 772621 gcttctctga tcgtagtgcc ggaagctgaa tcaacatacc atgtttttga accggcagtt 772681 ccgccgccgc cccctgtttg tccgcctaat tggccgacca agggaatctg catggccact 772741 cgatactgat cttttttctt atcaatggct gagctgacaa caaatgcaat gtcattgatt 772801 tctgtccggt cccagcaccc cgttagaagg atacaaatga gaagcggcaa aacacactta 772861 tatattgttt tcttcatctt ttgggtcctc tcttttcgct cccttctgtc cgttgccgcg 772921 cgaatacgtg cccggccttc tggtcatcgt ccaccaaggc gccctgacaa aaatatcttt 772981 tacttcatct cgtttaaacg gagaaatccc ggataaataa ggaatgccga aagattgcag 773041 cttgcataaa tgaagcacta agataatcgt gccgagcata atgccgaata tcccaaaaat 773101 actcgccaaa aacataagcg ggaaacgaag catcctgatg gagatagcta agttaaaccg 773161 cggaattgta aatgacgcga tccctgttaa cgatacgatg atcaccatgg gggcagacac 773221 aattcccgct tcaacagcgg ctgtcccaat gactagggcc ccgagaatac tgacggtctg 773281 gccgatggtt ttcggcaggc gcactcccgc ctcacggaga gcctcaaaag aaatttccat 773341 aatcaatgct tctatgatgg cggggaaagg aatcggttca cgcgcagagg ccacactgaa 773401 cattaagttt gtcggcatta agtcctggtg gtatgtaata acggcaacat aaatagccgg 773461 caaatataaa gcaacgaata aaaacatata gcgaagccag cggattaagt tagacatcaa 773521 ataacgctca tagtaatctt cactggcctg cataagctgc caaaacgtaa tcgggcctgt 773581 taagacaaag ggcgtattat ctgtgaaaat ggcaaatcgg ccttcgagaa gctgggcggc 773641 gacggtgtcc ggcctttctg tgtattgcag ctgggggaat ggcgagtacg tgtcgtcttc 773701 gataaattct tcaatatatc cgctttctaa gacagcatca atctttatct ttttgattct 773761 tttttttgct ttgtcaataa cctttggatc ggcaagcccg tcaatatagg ccaagacaac 773821 atcggttttg gttttcgtgc cgattttaaa agagatcatt ttaagctgaa acgttttgac 773881 gcgaaagcgc acaagagcgg tattgaccct gaggctttca gtgaagccct ctcttgaccc 773941 tctgatggtc gattctgtta tcggctcttc aatgcttctt ctttgtccgc cttttatatt 774001 taagatcagg ccttttgagt gcccgtcggc aaataaaacc gcgttcccct caatgatgga 774061 tgcagccact ttgctcatac tcgtttctaa tgcaacactt gaaattgata gagtattttg 774121 cagcgcctct tcatgttcat ctatttgatc cgtcaaatgc attaagaaag ggcggagggc 774181 gtgatcctga atatgttcag attttacaat tccttcgata taaacaataa atccgcacag 774241 cccgtttcca aagtcaaatt gtctaaatac gatgtctgag cagccttctg ttaataaggt 774301 cagattttcg aggttttcct tcaaattggg agagatcggt ctgtcctgat tgtcttcaag 774361 ctctttgatg agctgaagcg ctttgtcgcg tttattcata gaggctcacc ctgcttttta 774421 atgtcatatt caataagtgc ttgtgacttt tagggtaacc ttgtctgttt catatattcc 774481 agactaggat gaaagcgcta taaaaaagtg ttgactacct gtatatacag gaatacaata 774541 tgattataag ttgtatatac aagttataaa aacggatacg gaggggttgg catgggggaa 774601 ctgaacaaat cggcacgtca gattgtcgaa gcagtcggcg gtgctgaaaa tattgcagcg 774661 gcaactcatt gtgttacacg tttgcgtttt gctttaatag atgaaagcaa ggttgaccaa 774721 gagatgcttg atcaaattga tgtggtaaag ggatcattct cgacaaacgg acagtttcag 774781 gtcgtaatcg gccagggaac tgtcaataaa gtatatgctg aactggttaa ggaaacgggg 774841 attggcgagt caacaaagga tgaagtgaag aaggcctcag aaaaaaatat gaatcctttg 774901 cagcgtgctg tgaaaacgct tgcagatatt tttattccaa tattgcctgc gattgtcacg 774961 gcgggtcttt taatggggat caataacatt ttaacggcgg aaggcatttt cttcagcaca 775021 aaatcgattg tgcaggttta tccgcagtgg gcggatcttg ctaatatgat taacctgatt 775081 gcaggcacgg cctttacgtt tttgcctgcg ttaatcggat ggtctgccgt caagcggttc 775141 ggcggcaatc cgcttctcgg cattgtgctc ggggttatgc tcgtgcatcc tgatttgctg 775201 aatgcgtggg gatatggcgc ggcagaacaa agcggagaga tcccggtatg gaatctattc 775261 ggcctagagg tgcagaaagt cggctatcag ggccaggtgc tcccaatttt gcttgcttct 775321 tatatgctgg cgaagattga ggtattttta acaaaacgca cacctgaggg catacagctg 775381 ctcgttgtcg caccaattac gcttctctta acaggatttg cctcttttat cattatcggc 775441 ccgattacat ttgcgatcgg taatgtactg acttcagggc ttatctcggt gtttggttct 775501 tttgccgcac tgggcggtct gttatatggc ggtttctact cagcgctcgt gattaccggt 775561 atgcatcaca cgtttcttgc agtcgacctg cagctcatcg gttcaaagct cggcggcacc 775621 tttttatggc cgatgctggc gctttctaat atcgcacaag gttcggcggc tctggccatg 775681 atgtttatcg tgaaggatga gaaacaaaaa ggcctctccc tcacatcagg gatttctgct 775741 tatcttggca ttacagagcc tgccatcttt ggggtgaatc tgcgatacag attcccgttt 775801 atcattgcaa tggtcagctc tggcctggcc ggaatgtata tttcttctca aggtgtgctg 775861 gcaagctccg tcggtgtcgg cggcgtgccg gggattttct caatcatgag ccagtactgg 775921 ggcgcgtttg caatcgggat ggctattgta ttgatcgtgc cgtttgccgg aacatacgcg 775981 tatgcgagat tcaaacataa ataacaagtg gggagcggga cgtgttgaac gttccctttt 776041 cccgttttca atttaaatat ggtggtggaa acagatgaaa acagaacaaa cgccatggtg 776101 gaaaaaagct gtggtttatc aaatttatcc gaaaagcttt aacgatacga caggaaatgg 776161 tgttggcgat ctgaacggca ttattgaaaa gctggattac ttaaaaacgc tacaggtgga 776221 tgtgctttgg ctgacgccga tttatgattc tccccagcat gataatgggt acgatattcg 776281 tgattattac tcgatttatc ctgaatacgg aacgatggag gattttgagc ggctagtgtc 776341 cgaagcacat aaaagagacc tgaaagtcgt catggatctt gttgtcaatc atacgtcaac 776401 agagcacaaa tggtttcgcg aggcgatctc ttcaatagac agcccgtacc gtgattttta 776461 tatatggaaa aaaccgcagg aaaacggttc tgttccgacg aactgggaat cgaaattcgg 776521 cggctcggca tgggagcttg acgaagcatc gggccaatac tatttgcatc tgtttgatgt 776581 gacgcaggct gatttgaatt gggaaaatga agaggtcaga aagcatgtct atgacatgat 776641 gcatttttgg tttgaaaagg gaatagacgg ctttaggctt gatgtcatca acctgatttc 776701 taaagatcag cgctttccga atgcggagga aggcgacggc cgctcttttt acactgacgg 776761 gccgcgggtg cacgaatttc tgcatgaaat gaacgaaaag gtgttttcac attacgacag 776821 catgacggtc ggtgagatgt cttcaacaac cgtagaccac tgcatccggt atacgaatcc 776881 tgacaataaa gaacttgata tgacattcag cttccatcat ctcaaggttg actatcctaa 776941 cggcgaaaaa tgggccttgg cgccgtttga ttttttgaag ctgaaggaga tcctatctga 777001 ctggcaaacg gggatgcacg caggaggggg atggaacgct ctgttctggt gcaatcatga 777061 tcagccgcgc gtcgtatcaa gatatggaga tgatggcgca tatagggtga aatcggcgaa 777121 aatgcttgct acggccattc atatgatgca gggcacgcct tatatttatc agggcgagga 777181 gctggggatg acgaatccga agttcactga cataagctcc tatcgggatg tcgaatcgct 777241 gaacatgtat cacgccttta aggaaaaagg aatggctgat caagatatta cagccatttt 777301 acaggcgaaa tcccgtgaca attccagaac ccccgttcag tgggatgcta cggaaaatgg 777361 tggttttaca acgggcacac catggatacc ggttgcagga aattaccggg aaatcaatgc 777421 tgaagcggcg ctgagggatc agaattcggt gttttaccat tatcaaaaat tgattcagat 777481 tcgcaaaatg tatgacattg tgacagaggg tacgtatgag ataattgcaa aggatgaccc 777541 gaacattttt gcgtatctca gacacggcag caatgaaaag ctgctcgtga tcaataattt 777601 ttacgggaca gaggcggcct ttacactgcc ggactcttta gcgcctgacg aatggaaggc 777661 agaggtgctg ttgacgaacg atgaagcaag ggaagggctt cagaacatga cgcttcgccc 777721 atatgagtcc attgtttatc gtttaacgaa accgtgttaa actaagctgg gtggtccata 777781 atgaaggtga ataaattcat cacaatttat aaagacatcg cacagcaaat tgaaggcggc 777841 cgatggaaag cggaggagat tcttccgtct gaacatgagt tgaccgcaca gtacggtaca 777901 tcaagagaaa cggtccgaaa ggcgcttcat atgctcgcgc aaaacggtta tatccagaaa 777961 atcaggggaa aaggctccgt cgtgctcaat cgtgaaaaaa tgcagtttcc cgtttcgggc 778021 cttgtcagct tcaaggagct cgcgcaaacg cttggcaaag aaacgaaaac aactgtacac 778081 aaattcgggc tggagcctcc gtcagagctg atccaaaaac agctccgggc caatctggat 778141 gacgacatct gggaagtcat caggtctaga aagattgacg gggaacatgt gattttggac 778201 aaggattact ttttcagaaa gcatgtccct cacctgacga aagaaatttg tgaaaactcc 778261 atatatgaat atatagaagg agagctcggt ctttcgatca gttacgccca aaaagaaatt 778321 gtagccgagc cgtgtacgga cgaggacaga gagctgctcg atttacgcgg ctatgaccat 778381 atggtcgtgg tgagaaacta cgtctttttg gaggatacca gtttgtttca atatacggaa 778441 agcagacacc gtctcgacaa attccgattt gttgattttg cgcggcgggg gaaatgagag 778501 aggcgcctgc ctgcggcagc gcgctttttt gtttggtatc aaaattgata ctatccaaca 778561 aaaatgtgcg tacttttact ttttatcata atggctacaa tagagatgag agtaatctaa 778621 aggagaggtg ttttacatgg cagatctaaa gacacaaatt ctggatgcat acaatttcag 778681 gcatgcgact aaggaatttg acccgaataa aaaagtgtca gacagcgatt ttgaatttat 778741 tttagaaaca ggaagactgt ctccgagctc actcggcctt gagccttgga aatttgtcgt 778801 cgtccaaaat ccggaattcc gcgagaagct tcgtgaatac acatggggcg cgcaaaagca 778861 gctgccgacc gcaagccatt tcgtcctgat tcttgcgcgt acagcgaagg atatcaaata 778921 taatgcggac tacatcaaac gtcatttaaa agaagtaaaa caaatgcctc aagacgtgta 778981 cgaaggctat ttaagcaaaa cagaagaatt ccagaaaaac gatttgcatt tgcttgaaag 779041 tgacagaaca ttgtttgact gggcatcaaa acaaacctat atcgcgcttg gcaacatgat 779101 gactgccgct gcgcaaatcg gtgttgattc ctgcccgatc gaaggcttcc agtacgatca 779161 cattcaccgt attcttgaag aagaaggcct tctggaaaac ggaagcttcg atatttctgt 779221 gatggtggca ttcggctacc gagtgagaga ccctcgtccg aaaacaagat ctgctgttga 779281 agatgttgtg aagtgggttt aaaagaagaa agctgctcgc atagcgagca gctctttttt 779341 atgcctgatt cgctctattc tgttttctcc tctgatgtaa gtacattgcc gttccgagtg 779401 cgctgatcag aaatccggcc aacaggatcg agtacatgga tgtggctgtg tccggaagca 779461 ggccgccagc cggaccgtct gttcctgatc cgcccgaacc gtttccacca gagccgttag 779521 tcggttgagt gccgggaggc gtatcatttc ctccgtttcc gtcagttggc tgttttccgc 779581 ctggtttgtc ggagcctccg ccatgattgc cgtcatcacc gcctgtcggt tgatctgacg 779641 ggaatgccgg cggtttgttg tttgaaccgg aatttaagat cgtgtattcg ctgaagtggt 779701 ttgtatatcc tgtcaccata tcatcatcga ctgatccgtg acctgtcttt gtgaaagctt 779761 tcttttttct atcgacgtga taaatggcag ggttatgggc ttcttcaata tcaaacatgc 779821 gaagcgaaag ctgtacgggc tccttgaatg attttatttc ttttcctttt tgcttcactg 779881 taaagtcata tacatctgac agtgacacat ccaattctcc cgtagacttg attccgattg 779941 cagtgtctgc ggttttaagg ttcgccattg gcatcttcat gctgtaccag tagttgaaca 780001 tcgtcaatga aggatctgac tctctttctt tcaaaagttt gacctgatct tttttcactt 780061 taagattgat aggcttctct tgagatcctt catgtattcc ataatagaca aatggcgtgt 780121 tggcattttt agcataaatc gcaaatttgt cttcatcaag tgtccagctg ccgtccttct 780181 gctttgtcgg caggaatact tctttgattc gtccttcaac tttaggagag accttgtttc 780241 ctagtttttt cagctgttcg gtgaaaatct cataatcaac gtagccaagg tcttcaccat 780301 gggaggcttc tgtaaagaca gaatatccgt ctcctccggc accgacaaaa ttatttgttg 780361 ccacgcggta ggtatcatcc gtatttatag caactttgtc tccgttaggc gattcaattt 780421 tcacttctaa cacacggtgt ccaggtttgt tgtttaatgt aaaggtatat tcgattccgg 780481 ccacctgagg gaaagcgccg ccgccatttt ccacattgct taggccttgt tcaagggctt 780541 ctttaatttg ttttccggtt aaatcggcca cgtaaagcgt attgccgaac ggcatcacgt 780601 tgagcacctc gccgagtgtg atatcacctt tgtcaatgcc tgctctgatg ccgccgccat 780661 ttgttatcgc tattctggcg ccggctgctt ctttcgcttt tgccagcata ccgtccgcga 780721 tgaagtttcc gagattcgtt tctttcgtgc gcacatgctc acgctggccg tcaagcgcca 780781 catccgtgta gccgactttt tcatttttca cgtcctctaa ttcatttttg aactgatcga 780841 gctcttgttt tgcttctggg ttttcttctg tatgttcatc aattggcagc acgctcagat 780901 ttgatttatc tgtttgcaca acgccttttt catcaaacgc gacatcaacg cgccccaaga 780961 attggccgta ttcttttgcc tgcgccacga tcgtcggttc ttcgttgttc acgacctcca 781021 ttttgtctac gagggtgtga gtgtgtccgc cgatgatcaa atcaatgcct tttacttttt 781081 tggctagctc aagatcccgg ttatgtccga tgtgggttaa agcaataatt ttatttacct 781141 tttcttcttc ttgaatcgct ttgacggtgt tttgtgctgt ttcaaaggca tcattgaata 781201 cgatgctttt gcccgggctt gatgtggtgg ctgtatcttc tgttgtcagg ccgaatacgg 781261 cgactttctc cccgtcaacg tctaacagaa tgtaagggtg aatgccggcc tctttctttt 781321 cacctgccgt aaaggtttgc ggctttttga caaatgattt cagcttgggc tcatttgaca 781381 catctacgtt tgcactgaca atcggaaatt ccggcgcttc aaagtgatag cggttcgccg 781441 gatcaacggt tgcgctgttt ccgcttagaa aatcagaaag caccgtcggg cctttgtcaa 781501 attcatggtt tccgaaggtc atggcgtcat agcccatcat gttcatcatt ttcagatcgg 781561 ccaaaccgtt ccatttagta aaatacagat cgccggaaaa cacatctccc gcatcaagga 781621 gaatattgtg atttgtttcg ctgcgtactt cgttgatttt cgtcattcgt ctcgctgcat 781681 catcgagatg ggcgtgcgta tcattggtgt gcatgacggt cagatcccac agtccgtctt 781741 taggaggatc tggatttgaa tcatcatcga attgcagctt atacacacca tagccttcat 781801 tcgcagactt gcctacataa gcgacatcgt ctgctttatc ggcaaatggc ttggccaaaa 781861 gcgaggattc aaacgtcaga ttcgtgccgg aaacaggcgc gattgaccag ttgttgtctg 781921 cttttggatt gactgttttt tgttcaataa tgtaatccat cagcacctgc ctattttcaa 781981 ctgcagagcc gtggacaatt ttatcgctcg tcagatgagg gaacccgccg cctccggacg 782041 cacgatagtt attggtgact acgagaaatt cctggcttgg gctgatcggc ttgccttcat 782101 aggaaagatt gatgatacgg gatgaatccg cattgatcac ttttccgttc tcattgtatt 782161 tagccggttt tgtcacatcg acctgatatg tgacaccgtc aatcacgtca aaattatagg 782221 agcggaaatt ctcgttcagc aaggcctggt cgccgccttt agctggatca atttgattga 782281 attggcctgc tgacatctcc agccagtcct tgacctcgct gcctgtcagc ttgacgattt 782341 gaacagtatt atcgtaaaga tacaagtcac cgacattttt aatcgcaaga tctccggctg 782401 gaatgtttgt atagtaattg gctccgtttc tgccgcctgc tttaaacggc gctccagcgg 782461 ataaaatcgg caggttcttg tactcggtat ccttcatttc tttttcagcg taccactttt 782521 gcgcgtcagt cacgatctga atggaaggat catctttgac ctgtgcaaag aagctgttaa 782581 tatctgcttc ggttttgccg actggctttc ggacatactc cagtgtgttt tggtgtgttt 782641 gctgaatggt gtttgtaacg gtttcgtttc ttgatgtgac gttgccagca atagattcaa 782701 tacttccttt ggaatctgct accttccatg agccgtccgc cttttcaagc ttgaggtcaa 782761 tcacgcctaa atatttgccc cagctgcttg gcatgacgac aggaatgccg ttaattgttc 782821 ccttttccac attgaactga gcaacacccg catactcggc ggaaggaaag agtccgtgct 782881 gatggcccga gataatcgcg tcaatgcctt tcgttttggt ggcaaggtca aacacggcgt 782941 tttctgcgcc tgatgattgc gcctgctttt caatgccggt gtgggcgagg gcaataatga 783001 catctgcgcc ttccgccttc attttcggga tcgtttcatt ggcggattct acgatatcct 783061 gcacctgaac ttgcccctcg agattctttt tgtcccatgt catgatttgc ggcgggacaa 783121 agcctatgta gccgactttt actttctgct cattaccgtt ttcatcaatg agggtttttt 783181 cattaatcac atacggcgta taacggtttt cgccgctagt tgttttgacg ttggcattta 783241 caatcgggaa atcggctcct ttgattgtgc cgtcgagaaa gtcgagcccg tagttgaatt 783301 catgattgcc aagcgttccg gcgtcgtatt tcagcgcatt catgacgctg ataatcggat 783361 gggttttcgt gccggagata atgtcgtctt tttgatattt caccgcgtat tcacccagcg 783421 gattcccttg aatcaagtcg ccgttatcca caagcagggt gttagggttt tgctcgcggt 783481 gcttttggat caattgcgct gttctcgcca gaccgaaatc cgccgtttct ttgtcgctgt 783541 agtaatcgta atccatcatg ttggcatgaa tatcagtcgt agccaaaata ctcagatgca 783601 cctgaggagc cgcgctttct tctgcatgaa tgggtggtgt tgggaggatt aggctaagta 783661 tcataattgg gggcaaaaga atacggagaa tgttttcgac gtgtgttcgt cttttctgta 783721 ttctcaccag ttctccacct ttcaacgaaa tttgtgttac agctcctatt gtaagaatat 783781 tttgtaacta tttgtaggtg tttctttatg attattgtaa aagggagaaa aatgagtatt 783841 atgtagcagt atcaaacgac aaatactggg catttatgct tatcgtttgt cacaatcgcg 783901 gaatgtttat tttagtgtgg ctggggtaga gtgttttatg tagacatata aagcgggagg 783961 ttatgaatca tggggaaaaa aattgcagtt gttttaacat attattttga ggacagcgag 784021 tacactgagc ctgcgaaagc ctttaaagaa gcgggacatg aactgactgt catcgaaaaa 784081 gaaaaaggaa aaacagtaaa aggcaagcag ggaacagcgg aagtgacggt tgacgcgtcc 784141 attgacgacg taaattcttc agactttgat gcgcttttga ttcctggagg attttcacca 784201 gaccagcttc gcgctgacga tcgtttcgtc caatttacaa aagcgtttat gactgacaaa 784261 aagccggtat ttgccatttg ccacggcccg cagcttttaa tcaatgcgaa agcgctcgac 784321 ggccgaaaag cgacgggcta tacgtccatt cgtgttgaca tggaaaacgc cggtgccgac 784381 gttgtggaca aggaagtggt tgtttgccag gatcaattgg tcactagccg cacaccggac 784441 gatataccgg catttaaccg cgagtcattg gcattgcttg agaaataaga aaaaacggac 784501 gctcttgggc gtccgttttt ttgttgctta ggcttgagca cctgtcagtt tcttgtacct 784561 gtaatacaag aaagcagctg cagccgttcc gatgaccgca atgccgaagt cgaatatgaa 784621 aatatgggcg atgccccccg cttttgcgat aagccctgtt gcaatcggca gcagaatcga 784681 tgcaagactt gaagcagtcg ctacaattcc ggtaacggtt ccttttcgct tccagaaaag 784741 ctctgtcatt aacgtaatgg taatttgaaa cacacccgca gttgaaaagc ctaagaaaaa 784801 ggcagtgatg tccagcacaa ctgggatatg aacggtcagc atgactgcga gcgtacataa 784861 agtaataata ggatataaga gcgttatgaa gacaggtttg acccatctat tcagcaaaac 784921 ggctaataat aaaacagatg ccagagatcc tatactataa tagctcagca attgtacaga 784981 tgctgattca gctaaaccgg ctgccttttg cgcgtagctc gggagccaga tttgagaaac 785041 cgtaaataaa gccgtggatg taaaaccgat gataatcagt gcggtgcctt ccttctgaaa 785101 aacgggttca gacaagaaaa cgggagattc ctgttggccg ctattagttg gtttcttatg 785161 ttttttagga aacgaaagcg ttgataaata aataatattc aggagataga ccgctgccgg 785221 cagataaaaa gcaaatccgt aaaacatgct gtggtctgct aaaaatgtga tcaaaagcgg 785281 caaaagtgcg gcccccacag acataaaggc tttaaccaag acatttgccg aaccggaagc 785341 agacggaaag agctcggtta gggccggata tgttccggca tccatggctg aattagcgac 785401 tccggctaat aaagcgaaca caaacgccag ctcatagctc ggtgataaag gaataccgac 785461 taaaaagacg gccataattc ccgcagaagc gacaacaagc ggctttctgc cgattttatc 785521 tgatagaacg ccggaaatgc cgtatgtcag cagtttgcca aacccgatag cggcaatgac 785581 ataactgatg ccggtcggat cggtattcca ctgttttgtt aatgaagaca tattggatgc 785641 gagaatgatg ttgaccatcc ccagaaagaa gtagttgata tacattccgg atgctgtttt 785701 gatagatgtc gtttgcatgc ttgtactcct tcaaatctta ttcgaacact ttgctgtttt 785761 ggtttgggga aatgataaaa aagactcgcc gagtttccgg ccagtctcca ttatttacga 785821 agcgaggcta attcttgagc aatcgcctgc atttcacttg ggctgaatga ttcttttttc 785881 atcaccattc tgtgaaggta cgtgaggtct tcaatcttct catcactgaa atcctccgct 785941 ttgattacgc cgacgttcag catgttcagc ttttgggaaa tctcttcaat catttgagtt 786001 aatgtttctg tatttgggct ggacaaaggg ttccatcctt tctatgcgca atataggtat 786061 gttttattct aacagaattc catcagaaaa aaaccctatt ctaaaagcag gctgttcatt 786121 ccaaaaaagt gaagacatca gttgaaaaga aaatgaacat cctactaaga tattcatgaa 786181 ggtttctttt tagagaaata ggggcaaaga atagggaggt tgcacatcat gataagcgtg 786241 ttatttgttt gtttaggtaa catttgccgg tctccgatgg cggaagcgat ttttagggac 786301 ctggcagcca aaaaaggatt agaggggaaa atcaaggcgg actcagccgg tattggcggc 786361 tggcacatcg gcaacccccc gcatgaggga acgcaggaga tattgcgcag agaaggaatc 786421 agctttgatg gcatgctggc gcgtcaagtc agcgaacagg atctggacga ttttgattac 786481 atcattgcaa tggatgcaga aaatatcgga agtctcagaa gcatggcggg ttttaaaaac 786541 acctcgcata tcaaaaggct cttggactat gttgaagatt cagatctggc tgacgtaccc 786601 gatccttact acacagggaa ctttgaagag gtctgccaat taatcaaaac gggctgtgag 786661 cagttgcttg catccattca aaaagaaaaa caattgtgag tgaaaggaga atttgcatga 786721 acaacgaacg tttaatgctg aaagggatat ttctcggagc tgcggcaggc gcggcgttat 786781 cactgctcca taagccgaca agacaggcgt gcgggatgag atggctgaca tgcaagcata 786841 aactttcact gtacaaaagc aacccagagc tgttaaaaaa cactgtcatc acaaaagtgg 786901 atgaggccaa aaagctcgcc cgaacgcttt caaaggaagt cgactttgtg aaccagcagg 786961 tgaaagagct gaagaaaaca acgccgcaag tgatggaact cgtgcaagaa acgaaagagc 787021 atttttcaaa aaaatgatca aacatgcgag gtgagacgac atgagttttt tgaaagagct 787081 tttcagcaga tacacccttc atgaaggaca aagtaaatca gcggagctgg cgtatttttt 787141 tctattgtca ctgtttccgt ttttgatttt tatgctgacg ctcaccgcgt atcttccgct 787201 ttctaccgat gatgttttag gagtcataga acaatatgct cccgccagtg cgatgtcact 787261 cgttgaatcc attacccatc aaaccttaaa taatcgaaat ggcggtttgc tgtcattcgg 787321 gattatcgcc gcattatggt ctgcgtctaa tggaatgaat gcgatcgtcc ggtcgctgaa 787381 ccacgcgtat gatgtggaag aaaaccgctc ttttatcatt gttcgtctaa cctcgatttt 787441 tttgacgatt gccatggtat ttacgatttt agtggctttg cttctgccgg tatttggccg 787501 ggagattgga aggctcgctt ctgactttgt cggcgcgtcg gatctgtttt tatccgtctg 787561 ggccgccatt cgctggggtg tcagcccgct tgtgcttttg attgtttttt ccgcgctgta 787621 tgtgattgcg ccgaacaaaa agctgtctct ccggtttgtc atgccgggtg cggtctttgc 787681 gactatcggc tggatcattg tcagcacatt gttttcattt tacgtcagca cgtttgcgaa 787741 ctatagcgcc acttacggga gcatcggggg aatcatcgtt ctgatgattt ggttttactt 787801 gagcggcatt ttaattatcc taggcggaga aatcaacgct cttttacata aacgtaaaaa 787861 gcttcctgat gaaaatccct accattagcg caccctataa acgaacttcg gttcaaaaag 787921 aagtcggggg gatatcgtga tgaccaagca tacgaaaaaa ggcggaagcc ataacaaaca 787981 aaactcgaaa agcaaatcga gccataaaac aagcggaagc gccaacggac aaaacggcta 788041 ccattagcat aaaagcctcc tgacatgatg tcgggaggct ttttgattaa gaagatgaag 788101 aataggtttc agccggtgac cagcttttcg gtttgcccag cacaagggcc agccacacag 788161 agctaagcgt gagagtaatg aagtagaaca agtttgcgct ttcaaatgtc tgcatatacc 788221 agccgccggc aactgggccg aggatgctac cgagactgaa tgtaatgccg caaagcaggt 788281 ttcccgccgg caggaggtga ggcggaagaa ggtctgtcat atagctgatg ccaagtgtaa 788341 aggttgatcc gactgccatt cctgcaataa aaaagcagcc gccgatcacg tagggcgaag 788401 gaaatacacc ggcgatgaaa aagcaaagag ccccagtcag taaaatcacc agcagcacat 788461 tccgcctgcc gtatttatcg ctgaggatgc cgagcggaaa ctgaaagata atgcttccaa 788521 tcgcaaatgc gggaaggatg atcgctactg cgtctactga tatccccaaa cggagcgcgt 788581 acaccggaaa gcttccgttc agcgccgttt ccagaaagcc atagccaaat gtaggcataa 788641 aggcaaccca cccaaacagc atggcctgat aaaatcgcct gaaactattg tctgatttgg 788701 tttcatgagg actggtttcc gggtatgcat tttgtagaaa gaaaacaaaa agccacgcaa 788761 acagactgat gcagccggac acgataaaag gaagcgacgg actcagcttg acaagcggca 788821 ccatgaacgg gcctgcggca aagccaaggc caaaggaaag cccataaata gacaggtttc 788881 ttccgcgatt ttgttttgat gacatggagg tcacccacgt ttgcgtagaa aagtgaagca 788941 tgtggtcgcc gattccaatg aacaggcgaa gcaggaacca gacccaaact gactgaagcc 789001 aaataaatcc gaataagctt aaaatgacaa tgcttccgcc catgacgatc agcggcttga 789061 acccgagctt tctgagcggt gcttccataa acggcgaagc caaaagcaca ccgatataca 789121 gcccggtcgc gtgcaggccg ttgatagcag cggattctcc atttgtttca aaaatgattg 789181 aaatgacagg cagcagcatg ccttgtgaaa acccggaaat ggaaacgagc aagacaagga 789241 taaagaaatg aaatcgtgac atcgtgtcag ttctccttat atggaatcta tgttgatcgt 789301 acaacgtttt ccaaaagcag gcaacctgaa aaaagcctat atcacgctat acatttgccc 789361 tcgtgtaatc atgaaggttt ttgtgaagaa taaaaataaa acaagtcata aaaaaggagc 789421 tatttcacca tgaatcgtat cttttttatt ttagtggcgg ccggtgttcc gctttctgtg 789481 attggcagtt tgatgcattg gccttccgcg gttctatttg cagtttattg cgtgacgatt 789541 atcgcgcttg caagctatat ggggagggcg acagaatcac tgtccatcat tgcaggaccg 789601 cgtatcggcg gtttgttgaa tgcaaccttc gggaatgcgg tggagctgat tatttccctt 789661 tttgcattaa aagaaggcct gacaggaatc gtgcttgcct ctttaaccgg ttcagtgctg 789721 gggaacctgt tgctggtagc gggcctatcg ttttttgtcg gcggtttaaa atataagcgg 789781 caggaattta atatccatga tgcccgccat aactccgggc ttctgatttt tgccatcatt 789841 gtcgcctttg tgattccgga ggtattctct gttggtatgg gaaacgccag caagctcaat 789901 ttaagcatcg gcatcagcat cattatgatt ctgttatatg tggcggcgct gtactttaaa 789961 cttgtcacgc atcggggcgt ttatcagccg aataatgccg ctcagactga agaagaggaa 790021 gagccagaat ggtcagggaa ggttgcgacg attgtcttgt ttgcggcaac gattgtggtt 790081 gcatacatat ccgaaaacct ggtccatacc tttcactcgg tggctgaaca gttcgggtgg 790141 agcgagctgt ttattggggt catcatcgtg gcgattgtag gaaatgcggc ggagcatgcg 790201 tcagcgatta ttatggcctt caaaaataaa atggacattg ctgttgaaat tgcagtaggc 790261 tctacgctgc agatcgctat gtttgtcgca ccggttctcg tcatctgttc tatctttttt 790321 ccgacaagca tgccgcttgt atttacattg cctgagctcg tcgcgatggt atcagcggtt 790381 ctcttgatga tcgcgatttc gaatgacggg gattccaact ggtttgaagg ggcgacactg 790441 cttgctgcat atgtcattat ggcgatcggc tttttccttc tttaacctga aaaaatgatg 790501 gataacaaca aagcgggatg aaaagactaa gggaaaatgc catagaaaga gtgatatgat 790561 gaaaaagcta tttcattcca cacttattgt gttgttattc tttagttttt tcggcgttca 790621 gcccatccac gcgaaaaagc agtttaaggt tcctaattct gtcgcaagca tttcaaagga 790681 aaacacgtat ccgaatgctt cacaggatca gccaatgctt cagccgagca agctggcaaa 790741 ggaattgctc gatcattctg aggtaaagat tgaaaatccg catctcatca aaatgctgaa 790801 tgaatccaac atatccggca caccgcttgc agtagggtac cgggcgacaa tatttctcgg 790861 gaaatgggcg ctcggctatg aatcaaatga aacagtcgca aactgggaat ataaaaaaat 790921 caatacaaac cgtgcggata accgcggcgg gaaagaaacg gctgaaatgc attatgccca 790981 ggaacagcag tacagagtga agggcggctt gacagctaaa gttccaaatg ctgaagatgt 791041 caaaagcatg atgatgcaaa aagcaatgaa gaaaacgaac ctcccgcttg catttgagac 791101 ggtcatcggg gctggcacaa aacgggatca gatttataaa gtcgctccta aaaaaatcgg 791161 ttatctacat gcatatgcac cggctgtgaa tgaaaaagga aaagtgactt acggagaagt 791221 gtacttagtg ctgaaaggaa ataaacgaaa actcgtcgtg aaaaatgtca cgtcacaggg 791281 aatcggcgcg tggattccgg ttcaagatca tgtcacgttt ggctttcagc tttcctcact 791341 gccaagataa ataaaaaact gattccaact cggaatcagt ttttttgttt attgggttct 791401 ctcgattcgg accgcttcct caagcatttg cacattgttt tggtagagct ggcgaacgag 791461 aacccgtctt actgcaaggc tggcactgaa ataatcatca tctttcacca tgcctttaac 791521 cgtaaattcg acgccgcgat tgattttatt caatgcggtg atgccgtgga tttgaaacgg 791581 ttctgtcgga ttgccgaatt catcccgctt caatgaatca cgaagctctt cattcagcat 791641 gtcacatgcc tcttccaaca cgctgtacac gcggtccgga tcttctttaa agctgataag 791701 aaaggattcg gtaatccgca taaaatcaat attatagttc tctatttgtc tgacctcgcc 791761 gttgctgatg gtgagcagct tcccgctcca ttcccggatt tgcagcgagc ggaggccgat 791821 ttcctccact gtcccgttga acaagttgtt gacggtgaca taatcgcctt tgtgcagctg 791881 gcgttcatat attaagaata caccagccag cacatctttg atcagcgatt gggcgccaaa 791941 accgatcacg atacctgcta cgcccgcccc ggccaatatc ttgccgaaat catgcacaaa 792001 taaagaaata acgtaaaaga taaaaccaat tgttgccgta tactgggtga cagaacggac 792061 aaggctttca atcgtttttt cctttttttc ttcaataaag tccgtccgtt taaaaaatag 792121 ctgtaccagc cggttgatga taaagacacc gatccaaagg ataacggcaa cgaggagaat 792181 atcgacgatt ttattttgaa aaatctccgt aagtgtttct ttcatccgca tctaactcct 792241 ggcttgacgt tttgtgaagt ctgtatcctg ataataactg tttttgacaa gaacattcgg 792301 tccgaggcac cggacattcg ggcagtggca actcagttct ttcgcaagct tggtctctct 792361 ccacttttca taggcggaag ggaggctgtc cgtctgaatg ttgccaagcg gcggggtatc 792421 accgaaatcg gtcacgataa tgtttccgtc gaaaatgttc acattcaggc gggatcggcc 792481 gtcagggtca tttcgcactg tgacgttttt cgccgcgcga agccggcgaa gcagcttttg 792541 gtcgtcttcg tccggactgc aggcataaaa cggcagcgtt ccgaacagca tccacgtatt 792601 ttcatcacga atatccagca agcggtgaat ggcctgtctc atctctttca ggctgaggga 792661 ttcaagagcg cttgcgaaat cgcttggata cattgggtgg acctcgtgac gctgacattt 792721 catatcttct gtgatttggc ggtgaatatg ctcaatatgc ggaagtgttc gtttgttcag 792781 catcgtttcc gcagatacca ttactccggc atccacgagc gtgcggctgt tttcgatcat 792841 tttttcaaaa tagcgcgcgc gctgttcgaa ggtcggtttt ctgtccatca tggcaaagcc 792901 gatttcagca aaatcttcaa ctgttcccca gttatgtgaa atatgtagca catcgagata 792961 cggaatgatc cattcgtacc gctcgatgtc gagggtcaga tttgaattaa tttgtgtccg 793021 cacaccccgt tcatgggcat atttcaataa aggaacaaca tattctttta ctgatttcaa 793081 cgaaagcatc ggctctccgc ctgtgatgct gatggatctg aggcgcggga tttcctccag 793141 ccgttttaac agaagatcta ttggcagagc attcgggtct ttaggctgca atgtatagcc 793201 tacagcacaa tgctcgcatc tcatattgca cagtgtcgtt gttgtgaatt caacgtttgt 793261 cagctgcatg tctccgtatt ggtcaacatc catataggct tcccaagggt caaactcggg 793321 cgtaatcgga cgcagcttcg tgttttgtgt catgactatc taactccttt ataaatgggc 793381 atactaacgc tgccaacagt taattttaga cctgatttgc caagatcgca agtagcgcgg 793441 cgattgaaaa acggcaaaaa atgagctacc ataataaaaa atgaatggag gaacagaatg 793501 gggaacgccg taaacaataa agatcagcag attgattatt taaagaacag acttgacatg 793561 tttatgaacg tcatcgattc attagaccct gaagcaaccg acgttgaaga tatagacagg 793621 cttatcagca tgcttgatga cctggaagcc aaatacgaac gttttaaaaa agattgggaa 793681 taaaaccgcg tgcccgccgc ggttttttta ttggcataaa gcaacagtat aaaacaaagt 793741 ctctatctgt aaaataagaa aaaatgcaga aggagcgctg gccatgaagt ggatgtgttc 793801 aatatgctgc gccgccgtat tgcttgccgg aggtgcagca caggcggaag cggtgccgaa 793861 tgagccgatt aattggggct ttaaacgaag tgtcaatcat cagccgccag atgccgggaa 793921 gcagctgaac agtttaattg aaaaatatga cgcgttttat ttagggaata caaaggaaaa 793981 aacgatttac ttaacgtttg ataacggata tgaaaatggc tatacgccaa aagtgcttga 794041 tgtcttaaaa aaacatcgcg taacaggaac gttttttgtc accgggcatt tcgtaaagga 794101 ccagcctcag ctgatcaaac gaatgtcaga tgagggccat attatcggca atcattcctt 794161 tcaccatccg gatttaacga caaaaacagc tgatcagatt caggatgaac ttgattcagt 794221 caacgaagag gtttataaaa ttacgggaaa gcaggacaac ctgtatttgc gtccgccgcg 794281 cggcgtgttc agtgagtacg tactgaaaga aacgaaacgc ctcggctatc aaaccgtttt 794341 ctggtcggtc gcttttgttg attggaaaat caacaaccaa aagggaaaga aatatgccta 794401 cgatcatatg atcaagcagg cgcacccggg agccatttac ctgcttcaca ccgtatcgag 794461 ggacaatgca gaagcgctgg atgacgcgat tacagatctg aaaaaacagg gctacacttt 794521 taaaagcatt gatgatctga tgtttgagaa agaaatgagg ctgccgtctt tgtaaaagag 794581 aaagacctct ccttaaacgg agaggctttt ctttatttta tacatttaat cagtgcggcc 794641 cagtccagat ccccgaagcc tttctcaatc ccgctttcaa aatggctctt ggccagctcg 794701 gcaagaggaa gatttgcaga aacccgtttt gcggcggcga gtgccaggtt ggtatccttc 794761 agccctaaag acattttgaa gccggccggc tcaaatttct gctcggccat aatggttccg 794821 taattttgat agactggaga accaaagagc gcgctggcga tttctaaaaa ttgtttttgt 794881 tctaagccgt atttctccat cattaaaaag gattcagata acgcctccag catggacaca 794941 agcaagaaat taatgctgat tttggctgca tttgccgtct tgctttcttc gccgacgtca 795001 aatatctgct ggctcaggct gtcgagcaga ggcttggcag cttgctttgc ttccgccggt 795061 ccggctgtta tgatacggag cgcggctttg gctgcggcat ccggtctgcc aaggacagga 795121 gcggcgagaa aaaattgtcc tttctctgca tgagccgctg cgagcttttc tgagaactca 795181 acactgattg tgctcatcga gatgtgtatg ccgttctctg ctaatccttc aagcagcccg 795241 tcttctccga atgtcacggt gctgacagaa tcatcatctg caagcattgt gatgacaata 795301 tcagcggact ttgccgccag ccgcggcgta tcagctgcct gtgcgccttc tgtgacaagg 795361 tcttctgtct tttgtttcgt ccggttatag acagtcaatt cgtagcctgc ttgaagaaca 795421 tttcgggcaa tgggctgtcc catattgccg agtccgatga cagcaatttt caatctaatc 795481 actccctgaa tattttttcc attataaaca atatgaacag aatatgcata gcgatcggct 795541 tacaacaaaa aagaacagct gctcgctgtc ctcatttaaa aatattgaac catcctttat 795601 gtacaaacca aatcagcatt ccaatcacaa gcgcggccat caggccaagt acagcgaaat 795661 atccgtattt ccaatgcagc tccggcataa agtcgaagtt cataccgtat acaccggcaa 795721 taaaggtgag cgggatgaaa atggttgata cgatcgtcag tgtcatcata atcgcattca 795781 tccggtttga gtttagcgtc acgtagctgt cacgcaagtc ggacgtcatg tcacggttgg 795841 attccacaat ttcagacaac tttaacaaat gatcatatat gtcgctgaaa taggctttcg 795901 tttcccgctg ctctttcaca tggtcaaggc ttaaaatccg gtagagcaaa tcacgcatcg 795961 ggataatcgt ccgtctcaaa tgcaataggt ctgttctgag atcaaacacc tcgttcatca 796021 gcgttccata cgttttgtgg ggacggcttt cttcaatttc attcagccgg tcttcaattt 796081 tatacacgag aggaaaatat tcatcaacaa gctgatccat gatcatataa gaaatatgcc 796141 cgggcccttt tttcaatatg tccggtgaag catacaaacg ctcccggact ttagcgatac 796201 cgggcgtttc gtgtaaatga aaggtgacga caaatttttc gccttgaaag atatcgactt 796261 cctccgtctc aagtgtttcc ttattcagcg catgaatcac gtaaaaacga tagccgtcat 796321 aatggtcaag ctttggccgc tgcatatgct ggaagcaatc ctcaatggca agcgggtgaa 796381 aatgaaaaaa atctctcaat aacgccgttt ccgtatcctc cgggccgtaa aaatcaaccc 796441 agtaccatgc aatatcaggc tgttccactc gttcgatcgg tatatttttc agcagctgat 796501 gctctgttgt gattgcggta atgttgatca taaacaaccc tccacctgcc attatatcat 796561 gcggtcttta tgagaaaagt atacggtact ctctgcctaa ttccagcggc atgttatact 796621 gaacaaaaac ggaaaaaagg gtggatctca tgtggaagga aaaagtatct gtcacgcctc 796681 cgtatcattt tgaccgcgtg ctggacaggc tgtctttaga ccccctcaat gctgttgatc 796741 gagaggcgag ggaagtccgt gtgccaatca gaaatcaagc gggggacgta tgtattgtaa 796801 aggtacaggc gttaggccat gcgggcgagc ctgagttcct cgtcagcggg gaaacggatc 796861 agggagaaat gatgaaggaa atcaagcgga tttttcaatg ggaaaatcat ttgcagcacg 796921 ttctggatca tttttcaaaa acgagcctgt ccgccatttt tgaagagcat gccgggacgc 796981 cgcttgttct ggactacagc gtgtacaact gcatgatgaa atgcattatc caccagcagc 797041 ttaatctttc cttcgcttac acgctaacag aacggtttgt tcatgcgttt ggcgagcaga 797101 aggatggcgt gtggtgctat ccaaagccgg aaacgattgc ggaactcgat tatcaggatc 797161 tgcgtgatct gcaattcagc atgagaaaag cggaatacac cattgataca tcaaggatga 797221 tcgcagaagg cacactcagc ttgtcagagc tgccgcatat ggcggatgaa gacattatga 797281 agaaactgat caaaatcagg ggtatcggcc cgtggaccgt gcaaaacgtc ctcatgttcg 797341 gacttggccg tcccaattta ttcccgcttg ccgatatcgg cctccagaat gccatcaaac 797401 gccactttca gctggacgat aagccggcaa aggatgtcat gctggcgatg agcaaggagt 797461 gggagcctta tttaagctat gcgtctttgt atttgtggag gagtatagaa taattcgtct 797521 gacaatgaag gaaatcctgc aaacgtgtta tactagaaag atgtgaaaaa accatttcac 797581 tttctgccat ccgcagaaag cttcatatag aaacggagag aacaacgtga accaacaaaa 797641 gaaacaggcg cccgtcgaac tgaaggtcgg acaaactttt ccgctgacga ttaagcgtct 797701 cggcattaac ggagaaggtg ttggctattt taagaaaaaa gtcgtcttcg tgcccggcgc 797761 gcttcctggc gaagaagttg ttgtgcaggc cacaaaggtc cagccgaagt tttcggaggg 797821 ccgcattaag aaaatccgca aggcatctga gcaccgggtg gcaccgcctt gccctgttta 797881 tgaacaatgc ggcggctgtc agcttcagca ccttgcatac agccagcagc ttcgggaaaa 797941 acgtgatatc gtcattcagt ctcttgaacg ccatacgaag tttaaagttg aaaacatgga 798001 aatcaaagaa acgattggca tggacaaccc gtggaattac cgcaataaaa gccaattcca 798061 gatcgggcgc tcgcaaagcg gcagcatcat cgccggctta tacggccttg attctcatga 798121 tatcgtgccg attaaagact gtatcgttca gcatccggca acgaacaaaa caacaggcat 798181 cgtccgccgc attttagagg acttcaatgt gtctgtttat aatgaaagaa aacgaaaagg 798241 cgacgttcgc acgatcgtga cgagagtcgg ctttgaaaca ggcgaagtgc aggtcgtgct 798301 tgtaaccgca aaagaaacgc ttccgcacaa ggaagaaatc gtcaaagcga ttcaaaagcg 798361 attgccagag gtcaaatcca ttattcagaa tgtaaacggg gcgaaaacct cagtgatttt 798421 tggtgagaaa acaaaacagc tcgccggaaa aacagtgatt caagaagtgc tcggcgacgt 798481 atcttttgaa ttgagcgccc gcgctttctt ccagctcaat ccggaacaga ccgtcaagct 798541 gtatgatgaa gtgaaaaaag cggcgcagct gaccggaaaa gaaaaagtcg ttgatgcgta 798601 ttgcggcgtc ggcactatcg gcatgtgggt tgcggacgga gcgaaggaag tccgcggcat 798661 ggacgtcatc aaggaatcaa ttgacgatgc taagaaaaac gccaaaaaac acggcatggc 798721 aaatgccaca tacgtaacag gaacagccga gcactggctc ccgaaatgga cgaaagaagg 798781 cttccgcccg gacgtcgtca ttgtagaccc gccaagaacg ggctgtgaca gcacgttctt 798841 ggacacgatc aaaaaagtca aaccgaaacg ctttgtctac gtttcctgca atccatccac 798901 gcttgcgaaa gatttgcaga cgctgtcgaa ggactatcgc gtggactata ttcagcctgt 798961 cgatatgttt ccgcagacgg cgcatgttga agcagtggcg aggcttgtat taaaatcgtc 799021 taactaaaaa gaacatttcc cagtcataaa atagttttcc taataagacc tggatttcgg 799081 taaaataaac aattccgatt tccgggtctt tttcgtgcgc agctcttgtc ctaacggtct 799141 gttctcaatt ttatcttcct tcttttcgcg gagatcttta ttttaactgg cgaaaagaat 799201 tgaaaaaacg tgttgaaaag caggtgaaaa aaagcgttat ttaaccggaa aaatatcctc 799261 ccagtatgtt taaaatacat gagtagaatg atgtaaaatc atagatgtat tttcataatt 799321 tgtaaaatta tatattgact tgcagttatt acgtgtgaaa tattgatgat aggaatataa 799381 ggaaagtatg gcgtatatca tttcaagagt cattcgatgt aaaaagttga aacattgtaa 799441 taaatgaaag aggtgaaaat gatggccaac cccattttaa aatgcataac gtatgagcac 799501 tacaacaatt aaataatagt gccgagacga taacaactat tacagtaata cctacaatgg 799561 ttatatcctt gcgacaatca tgcttcataa tataatgatt ttagattgac acttggctaa 799621 aaagtattgc agagaaggaa atggataatt aaatggataa agtatataaa agaagttggt 799681 ttcaaacatt tttggcattt ttagtatctc agctttattt taattttgta gaattaacgg 799741 gatggggtcc taagtataga gaaatgaatg gattcccagc aaacatagtt gaactagatt 799801 tctttcaaac atatctttca ttctatgata atccatggtt taatattatt actgttttct 799861 tgggagtttt cactattata caaataatta cagggataac aaaggatatt cgaaattaaa 799921 gcaataactt ctgatgcctt atttaatgat gaaagaaaat gtacactttc ttaattatct 799981 tatgagtgaa gactgcgaca cttagtcagc agtctatttt atggttctgg atcaggatta 800041 ccgaattata accctataca aatatatagt aggttgccac ttgctgcgtt ggttattttc 800101 taaatcatga gcaaatccca aatgattcag attgaagttc ttgaattctt ttaaataagg 800161 gtttattttc tcttctcatc ctctttactc catgtgattc acaagtggta gcagcttaag 800221 taggtttttt cattctcttg agtactcagt tataccaccc ccaactcaat ttgctttatc 800281 tctattagtt tttccgcaaa tatgatatag agatacggat atggtgtagt gttaaatatc 800341 ttatcttcaa taacagggca attattttgc gttggtaata tggagaactc atatgatatt 800401 ctatttaggt tggaatcctt tttatccaaa aagttcaaaa gcaaggccac taagaaagac 800461 gaaggtcagc gccagttaac cagaatataa aaaatagggt agataatcat cccacgtgaa 800521 atcttcaaaa tttactatag attgataaga aatgctttcg catgcgataa gtgtaaaaga 800581 agcatggtca gtttttaatt tgggataaag gttcagccgt atcccataat gaaaggattt 800641 gatttttgtt atgacagaaa atttctggcg tgaattacca cggccgtttt ttgtactggc 800701 accaatggaa gatgtgacag atgttgtttt ccggcatgta gtaagtgaag caggcagacc 800761 ggatgtgttt tttacagagt tcacaaactc agagagctat tgccacccgg atgggaagga 800821 tagcgtgcgc ggccgtttga cttttacaga ggatgaacag ccaattgtgg cccatatatg 800881 gggagataag cctgaaaact tccgtaaaat gagtattggc atggcagagt taggatttaa 800941 aggactagat atcaatatgg gctgccctgt gcctaatgtg gcggggaatg gaaagggaag 801001 cggccttatt tgccgtcctg cagttgcggc agaattaata caagctgcaa aagcaggggg 801061 attgcctgta agcgtgaaga caagacttgg atacacggat gtggatgaat ggcgcgagtg 801121 gctgacacac attttgaaac aggatattgc gaatctttct attcatctgc gtacaagggc 801181 agaaatgagc aaagtagatg cgcattggga gctcatccca gagattaaga aacttcgtga 801241 cgaggtggca ccagatacat tgctaacaat aaacggggat attcctgacc gtcaaactgg 801301 cttgaaactt gctgaacaat acggcgtcga tggaattatg atagggcgcg gtatttttac 801361 aaatcctttc gcttttgaaa aggagccgaa agagcatagc agcaaggaat tgcttgatct 801421 cttaaggctg catctggatc tccatgatga atattcaaaa gaagaagccc gtccatacaa 801481 gcctcttcct cgctttttca agatttatct ccgcggattc cgaggggcaa gtgaattaag 801541 aaatcaatgc atgaacacaa agtcaacaga tgaagtgcgt gcattgctcg acgactttga 801601 gagaaagtat cttgatggga tagagtaaca gcagtgcttg attcaaaaaa ggctaacaaa 801661 ataaagggat ttttacacaa ttcttgacta aaataaacct ggattttcgg taaatccggg 801721 tcttttttgt acgcagcttt tactcagcct gtcttttctc taatttattg taagaaaata 801781 atggtatatt tagtggagat atcatataaa gggggagagg aaaatgaaac ggctatgcat 801841 catcccctgc ggcaagaaaa aaatctggga tgtccagcct gatgccgggc cggtaagagc 801901 agaggacgct tatctcagcc cgtttcatca ggcgtgcgag cggtatgcaa aaacattttt 801961 cgatgagtgg gtgattttgt cggcgaagca cgggttcctc cgccctgatg atctcgtttc 802021 gggaaattac gatgtcactt ttggcaccgg tcatccggaa atcatgacag cggacgagct 802081 gcgccgtcaa tttcacgaaa aaggcttttc tgatatcgaa gagctagtca tgcttggcgg 802141 aaaaaaatat cgaagcgttc taaacgccgt catcggagaa caccagcata tcagctggcc 802201 gctatcatca tacaaaggca taggctatat gctccaagcg ctgaaccggg ctgttgaaga 802261 aaagcatgaa ctgtagcacg tacatatgag gaaaagagtg ggaacatgaa aaaacttgtg 802321 tttggcttgc ttgccattgt gttattcgga tgcggactat atatctatca tgtatggttc 802381 ggtgatccat tttcgaaaaa tgctgcagaa cagaagctag tgtcttatgt gaaacaaacc 802441 tatcctaaga aagaaatcaa gatcacgaat ggggtatata acgctaaaac gtctgaatat 802501 gtatttgaag caacctccca atctcatcgc tacccaatgt gtacgaaggg atttctgcat 802561 cctaaagtaa cgtgcgatgg aattgaagaa gcgtataccg aatcagtagc aaaacatgta 802621 aatgaagaag caacgaaggc aatcgaagca gatctgaaaa aagcggttcc tcgatttata 802681 aaagctgatg ctgctttgag tatcgaaaac ggacagttca cgttagatac aaaatggaac 802741 aaaaagctgg ctgaaaaagc gcctatgagc atgacgattc agttagacgc cagcgggtta 802801 tcaaaaacag atgccgcaaa gatggcggaa acggtcagaa aaacgcttaa tgaaaaggga 802861 tatacatact caaacggcac gatagactgt atgcagaagg acggggacgg cggtattgga 802921 tatgtcaaat attcaattga ttttctttca aaagcagcta ttcagtcaaa cgatgcagag 802981 gaactaggaa gttaaaaaga tttccaagga aataaatacg tcgatcattg tcaaaggccg 803041 ggtgatatcc ggtctttttt ttgcatgctg taaaacgaga caaatgaatc agtttgagac 803101 aaaacgagac acacgtctca aactgtctcc aaagtgaaga tgagaagact gattttacgg 803161 gctcaaaaga ctggcacact tcttgcattt ataatggtga accctaaata gaaggaggcg 803221 cacaaaatga aattgttaaa acgagaaggc ttgtcattaa ctgaggaaaa agcgctgtgg 803281 atgtaccaaa agatgctgga gatcaggggc tttgaagaca aagtgcatga actgttcgcc 803341 cagggagtgc ttcccggatt cgttcattta tatgccggtg aggaagccgt ggctgtaggg 803401 gtgtgcgctc atttacatga tggcgacagc attacaagca cccacagggg acatggacat 803461 tgtatcgcca aaggctgtga cctggacggc atgatggcgg aaattttcgg gaaagcgacc 803521 ggattgtgca aaggcaaggg cggttctatg cacattgcgg atcttgataa aggcatgtta 803581 ggcgcaaatg gaatcgtcgg gggcggcttt acgctcgcat gcggatcagc gctcacggct 803641 aaatataaac agactaaaaa tgtaagcgtt tgctttttcg gggacggggc aaataaccaa 803701 ggtaccttcc acgaagggct gaatttagcg gctgtatgga accttcctgt cgtatttgtt 803761 gctgaaaaca acggctatgg cgaagctacc ccatttgagt acgcatcagc ctgtgattca 803821 atcgccgatc gggcggctgc ttataacatg ccgggggtta cagttgacgg caaagatatt 803881 ttagcagttt accaggcagc cgaggaagcg atagaaagag caagaaacgg cggcggcccg 803941 tctttgattg aatgtatgac ctacagaaac tacggccatt tcgaaggaga tgcccaaacc 804001 tataaaacga aggatgaaag agttgagcac cttgaagaaa aagatgccat tcaaggtttt 804061 aaaaactacc ttttaaaaga aacagatgct aataagctgt cagacattga acagcgtgtc 804121 agcgaatcga ttgaaaaagc cgtctcgttc agcgaagaca gcccatatcc aaaagattcg 804181 gagctgctga cagatgtgta tgtgtcatat gaaaaaggag gaatgtaaga gatggcgaga 804241 gtcataagca tgtcagacgc gatcaatgaa gcaatgaagc ttgcgatgag aaaagacgaa 804301 aatgtgcttt tgatcggtga ggatgtcgcc gggggagcgg cggtcgatca tttgcaggat 804361 gatgaagcat ggggcggtgt attaggggtc acaaagggac tcgtacagga attcgggcgt 804421 acaagagtgc tggacactcc gatttctgag gcaggctata tgggagcggc tatggctgcg 804481 gcatcaaccg gtttgagacc gattgccgag ctgatgttta acgattttat cggcacgtgc 804541 tttgatcagg tgatcaacca aggggcgaaa ttccgttata tgttcggcgg aaaagcgcaa 804601 gtgccgatta ccgtccgcac cacatacgga gcagggttcc gggccgctgc ccagcattca 804661 caatcgctgt atggcctttt cacgagcatc cctggactga agacagttgt tccatccaat 804721 ccgtatgatg ccaaaggtct tttgcttgca gcaatagaag ataatgatcc ggtgtttttc 804781 tttgaagaca aaacgtccta caacatgaag ggcgaggtgc cggaagatta ttatacaatt 804841 cccctcggaa aagcggatat caaacgcgaa ggcaatgatg ttacgctctt tgcagtcggc 804901 aagcaggtca atactgcgct tgaagcggct gcacagcttt cagagagggg catcgaagcc 804961 gaggtccttg atccccgcag tctgtctcct ctggatgagg atgcgatttt cacatcgtta 805021 gaaaaaacaa accggctgat catcattgat gaagccaatc cgcgatgcag cattgccacg 805081 gatattgctg cgcttgtcgc tgacaagggc tttgatttgc ttgatgcgcc gattaaacgg 805141 attacagcgc cgcatacacc ggttccgttt tcaccagtgc ttgaagatca atatttgccg 805201 acaccagata aaattgtcag cgtcacgctt gaattgcttg gcgagccggc attgaattaa 805261 aggggggaca caaatggcgg taaaagtagt gatgccaaaa ttgggaatgg ccatgaaaca 805321 aggggaagta tcgatatgga ataaaaaagt aggcgacccg gttgaaaagg gagaaagcat 805381 tgccagcatt caatcggaga aaattgaaat ggagatcgaa gcgcctgaaa aaggaacgct 805441 gatcgatatc aaagtgaaag agggagaaga ggttccgccc ggcacagcta tctgctatat 805501 cggggacgcc aatgagtcgg tgcaggaaga ggcgggggcg cctgttgctg aagacaatat 805561 gccgcaagcc gtccagcccg tcaaacaaga aaacaaaccc gcagcctcca aaaaagatcg 805621 aatgaaaata tctccagtcg ccaggaaaat agcagaaaaa gcaggattag acctaaaaca 805681 actgaaagga actggaccag gcggacgaat cgtgaaggat gacgtaacaa aggctcttgc 805741 tgaacagaaa aaagatcaag caaagcctgt ttcggagcag aaagcgcagg aaatcccggt 805801 gacaggcatg agaaaggtca tcgctgcccg aatgcaggaa agcctggcaa acagcgcgca 805861 gctgacgatc acgatgaaag ctgatatcac caagcttgcc actcttcaaa aacagctttc 805921 accaactgcg gaagagagat acggcacaaa actgacgatc actcattttg tctcaagagc 805981 cgccgttctc gctctgcaag ctcaccctgt gctgaacagc ttttatcaaa atgagcgcat 806041 catcacacat ccccatgtgc accttggtat ggctgtagcc ttggaaaatg gcttagtggt 806101 gcctgtcatc cgccatgctg aaaagctatc gctgattgaa ctggctcaat ccatctcaga 806161 aaatgccaaa aaagcacgcg agggacgtgc gggaagcgaa gaactgcaag gatctacttt 806221 ctccattaca aaccttggcg cgtttggagt tgagcatttc acaccgatac taaatccgcc 806281 ggaaacaggc attctcggca tcggagcaag ctatgacaca ccggtgtatc aaggggagga 806341 gatcgtcaga agcacgatcc tgccactcag cctgacattt gatcacagag cgtgtgacgg 806401 cgcccctgcc gctgcattcc tgaaggcgat gaaaacatat ttggaagaac ccgcagcatt 806461 aattttatag gaaaagcagg tgaaaacgac atgacattag ccattatcgg cggcggacct 806521 gcaggctatg cggctgcggt ttccgcggca cagcagggca gaaacgtgct gctcattgac 806581 aaaggcaagc ttggggggac ctgcctgaat gaaggctgca tcccgacaaa gtctttgtta 806641 gaaagcgcaa acgttcttga taaaatcaag catgccgaca gctttggaat cgaacttccg 806701 gcaggtgcga tatcagtcga ttggagtaaa atgcaaagcc gaaaacaaca ggttgtcagt 806761 cagcttgtcc aaggcgttca gtacctaatg aagaaaaatc aaatacaggt tgtaaaggga 806821 acagcctcct ttctttctga aagaaagctc ttgatcgaag gagaaaacgg aaaagaaatc 806881 agagaggcgg accaagtatt gattgcctcc gggtcagagc caatcgagct gccttttgcc 806941 ccatttgacg gcgaatggat cctcgacagc aaagacgcgc tttctctttc cgagattccg 807001 tcttcactag tcattgtcgg cggcggtgtc atcgggtgtg agtatgcagg gctgttcgcc 807061 agattgggat cgcaggtgac catcattgaa acagcggacc ggctgatccc ggctgaagat 807121 gaagatattg cccgtctctt tcaggagaaa cttgaggaag acggtgtcga agtgcatact 807181 tcatccagat tagggcgggt ggatcaaacg gccaaaacgg caatatggaa aagcggtcag 807241 cgagagttta aaacgaaggc cgattatgtg ctggtggcga tcggcagaaa accccgtctt 807301 gacggattgc agctggaaca ggccggagtt gatttttctc caaagggcat tccggtgaat 807361 gggcacatgc agacgaacgt gcctcatatt tacgcgtgcg gagatgctat agggggcatt 807421 cagctcgcgc atgccgcttt ccatgagggc atcatcgctg cttctcatgc ttccggaagg 807481 gatgtcaaaa tcaatgagaa acatgtgccg cgctgcatct atacgtcccc ggaaatcgcg 807541 tgtatcggaa tgacagaacg acaggcaaga agcatatacg gggatgtgaa gatcggcgaa 807601 ttttcatttt ccgcaaacgg caaggcgctc attaaacagc aagcggaagg aaaggtcaaa 807661 atcatggctg aaccggaatt cggcgaaatc gtgggtgtct cgatgattgg cccggatgta 807721 accgagctca tcggccaagc ggcagcgatc atgaatggtg agatgacggc agatatggcg 807781 gagcatttta tcgccgccca tccgacttta tcggaaacat tgcatgaggc gctgttaagc 807841 acgatcggcc ttgcggtaca tgcataataa aggaaaaagc aggcgcatgg atataaggcg 807901 cctgcttttt tattgttgaa agcgctttat ttttccccta caatagatga aaacggcgtg 807961 taagggagga gcgatcaagg aaatgaattc ggtcccaaac gatttgcaaa cctggaaacg 808021 ttttgtgaaa gacggtgtgc ttgacgaagc ccgattaaga aaacggattg cagagtcatg 808081 gcatcgctgc aaaaaagctg aggtcaatcc ttatttagaa aaaggcccga aggttttaca 808141 gcaaacggag ctggatcagc agtcaaaaaa acattcattc ttcttgacga ccgcaaagcc 808201 ttacctcgaa aaactgctgc ctgccataaa agaaatggaa atgatggcgc tgttaattga 808261 ttcagacggt gttgttctgg cattggacgg ccatccgcgc gcgctctatg aagccaaacg 808321 catcaatttc gtcgaagggg catgctggac agaaacggct gtcggaacaa atgcgattgg 808381 cacggcgctc cacatcagcg agccggttgc aatacaagga tcagagcatt actctatcgc 808441 ttcccatctt tggaactgtt cagctgctcc gattcaccat gaggatggca gccttgcggg 808501 tgtaattgac atatcatgcc cggcggcagg cgcgcatcct catatgcttg gtattgccac 808561 ggcgattgcc tatgccgctg aacgggaact cgcagctaaa agccgtgaga aagagctgga 808621 gctgatcagc cgttttgggg agagagctgc atccagtgtg ccgatggtgc tctgtaatac 808681 caagcagcac atcatcagtg cgagcatgcc gattcgaacc tcaatgccgg attggcaggg 808741 ccggcacctg tacgagttga aggaacgggg ctattcaatc gaaaatgctg tcaccatagg 808801 agatggcggc acttgttttt atctttcgga acaaaagaaa aagaaggcgt ttcgattcaa 808861 tggagtgatc gggcaaagcg gccgatcgca agcgatgctg atgcaccttg aacgagcagc 808921 tgcgacggat gcatcggtct gtttgtcggg tgaaacgggt acggggaagg aggtcgcggc 808981 tcgcgcgctt catgagaaca gtgagagacg gcacggtccg tttgttgctg tcaattgcgg 809041 agcgattccg tctgatttga ttgaaagcga actgttcgga tatgcagagg gcgcttttac 809101 gggagcgaaa cgaaatggct ataaaggcgc ctttcaaaaa gcgaatcaag gcacattatt 809161 tttagatgaa atcggagaaa tttcccactc gatgcaggtt gcacttttac gggtgcttca 809221 ggaacgcaag ataacgccaa tcggcgggac gaaagaaatt ccggttgata tcagagttat 809281 tgccgccaca cattgtgatt tacgcgagct tgccgaaaac ggaaaaatca gagaggactt 809341 gttttaccgt cttcatgtct atccaattga actccctcca ttacgcgatc gcaccgagga 809401 tatcccggat ctctttgagt actacaaaca gaagaatcat tggccaggcg atcttccttc 809461 tgatttttgt aatgtgctga agcaatggaa gtggccgggg aatatccgcg agctgtttaa 809521 tgtgtttgaa cgtctttcta tcagatttcc ggacggccgg ctgagagatg aatcgcttcc 809581 cgctttactg gaagccgctg gattgccggc cagctctgca gaaaaaaagc cggctgctgc 809641 cggcgtgctt acttttcgtg agcaaatcca aaaggatatg atgatcaaag cgcttgaatc 809701 tgcaaaagga aacgtctctc aagccgcaaa aatcagcggg atcccccgaa gcactttcta 809761 caaacgcctg aaaaaattca acttgtccgc tgaatcataa agcatacttc cttcaggaaa 809821 tggaaacgtt atgtattgaa ggagggtgtt acgatgaata ttcaaagggc gaaagaaatt 809881 gtagaatctc ccgacatgaa gaaagtaaca tataacggcg ttcctattta cattcagcac 809941 gtaaatgaag aaactggaac agcaagaatt tatccgcttg acgaaccgca agaggagcat 810001 gaagtgcagc tgaacagctt aaaagaggat taaacaaaaa tggcccgctt cataagcagg 810061 ccattttgtt atccgcgcgg cgcaaataaa ataacacaga caccgatgag acaaatgaat 810121 gcgccgatcc agtcatacag atcaggtgtt ttccggtcaa caagccatcc ccacaggacc 810181 gcaagcacga tgaatactcc gccataagcg gcgtatacac ggccgaaaga tgggaaggac 810241 tgaaacgtcg gaagaatgcc gtatacaatg aggatcagcg ccccggcgat tccgtagcca 810301 gctggctttg cctctctcag ccatagccaa accagatatc cgccgccaat ttcagcaagc 810361 cctgccgcga gaaataaaag aatggtaatc agcatcatga gcactcctca atttgcattt 810421 atctttcatt atagaggagg agagctttta aagcttcgga tgattctcaa attccttcaa 810481 atacgctttt cgctgaacct ctgtaaattg gctgatccaa ttgttttgag cctcttcatt 810541 caaatgggga aggatatagc gttcaaccgc ttcgaaaaac agcggattcg tgatgatgtt 810601 ccaggtcggg attcgaacga ttttgccgtc tgttttctcg atgataatat cctcaaaaaa 810661 gatccctttc aaactgtatt gatggcgtcc catataaagc cgcttcacct cggaaaacag 810721 cacgctgcgc tttctcaaga agatttcgcc actaggtccg gtctttatgg tgaaaatgac 810781 atttccacgg cttgtgaacg caggaaaagc cataaagaat gtgatcaatc cataaatcat 810841 cgccagtaat ccgccgccca aataaagcag ggcatattta gattcaaacg tgagggcttc 810901 agacaccagc cagactccca caataaaggc gccccctgta gcgaggaaca gccaagccct 810961 tagaaacatc atgcttttta cttcaatcat gtgctgcccc taaagcttcg gatgattctc 811021 aaattccttc aaatacgcac tgcgttggat gtctgtaaac tgtccgatcc aattgctttt 811081 cgcctcttca ttcagatgtg gaaggatata gcgttcaacc gcttcgaaaa acaacggatt 811141 cggaatgatg ttccaagtgg gaatgcgaat ggtcttctga tccacggttt ggatcaatat 811201 atcttcttgg aagattcctt ttagactaaa tttatggcgg ctcatctcaa ttttcttgat 811261 atcagtaaac gtaacagaca ctttgtcagt gaacacttct ccattttttc ctgtcttgat 811321 gcggaaaatg gtatttcccc gcggggtgaa agccggaaag aagatgataa ataaatataa 811381 acaaaacaag gtgaacagaa agccagcagg aatggctaat aggtaatatt tcgtttgaaa 811441 cgtaataccc atataaaaga gccacaaaca tgctaatccc ataccggcag atccgacaaa 811501 agcccatatt ctcaggaaca ttttgctttt gacttcaatg atttcttggt ttttcaatgc 811561 ttttctcctt ttgttaattc aattcttatc attttgaaat gatttgattt acaacatcct 811621 tatgagcagg gaggatagaa aattcattct gggtgatgcc tgtgacaagc caagtatggt 811681 gggcccccgg caggacgaat gccatgtcag ccacttcagg agtgttatct tttccatatg 811741 ccagacgcat aagtgtatcc attttccctt tccgcaaagc cagatcattt gcaaatcggg 811801 taacgtcctc ttggtggtca tgtttttcaa ggaactcttt tagatatgaa gggttgtctg 811861 aagcgccctc caagagtttt tcaaattcat ttgatgtcaa tgttacaatc gattctcttt 811921 tatcctctgt atctattata tgtaaaaact catctgtctt agcaagtaac ccttcacttg 811981 attccatttt tgtaatgcga tggacttgtt catcaaaaag gagttcgtga gagtaggtgc 812041 cgaattttga tacatggcat gacacattct gttcggcacc ttgcccgtta aatttagaaa 812101 gcttcactgt atagtcagcg tcgtttaata catggataaa cggacagtac tcgtccttta 812161 accgatattg atggttccga tattccgctg catccttggc taagagtgag cggcacgcgg 812221 cttcaaataa ggcgccgagc tgttcatctt ctatttccgg aaaataggcc tgcttcaagg 812281 ccattccctg ttcaaaaaac ccttcgctgt aaaagcaaaa caagagttct tctatgctaa 812341 ttgtaaactg cttcattgtt tattctccta tccaaatgaa aatttccctt taaggaaatg 812401 ggttgcgccg tgtataagcg aatccgctgt tttctttgct ttttccattc cttttttcgc 812461 gctgtctatc cctttatgta tcgatttatt cgccgcatct atgccgtcat tcactgattt 812521 gacgactttg ccggctgatt ccagcccttt tttggctgta tcaacaacag catggatcgg 812581 ttctttcagc tttaaggctg ctttttcagc aaaaccggct gtatatttgg cgatttgttc 812641 tccgacgact ccgccaatgt atgaacctgc tgccccaaga aggacagtac ccacaggtcc 812701 tgcaaagctt ccgattgcac cgccgatgac agcaccagct gtggcaccgc cggcaacaaa 812761 aatcgtatta ttcacagcat tcccgacggc cttggcgttt tcacgcttga gaacttccgg 812821 tttatcctgg tattttgcat aattttcagc aattttcacg cctgctccga atgtttcggt 812881 cgctccggta atcagtgtgg cggtaatggc atttcctttc gcgaatctca agcccgtttt 812941 tcccacatcc ttcaaagtgg agcgtacgcc ggcttcatta agaaatcctt ttgtgtagct 813001 tctgacgctg tttgaaaaat ccaccgtgtc ctgaggaaag tattttgtaa actttttatg 813061 taccaaatct gaaaatggac ggtttgtctt tttcaacaaa tatttaggat tcaaaagcac 813121 tcttgccgct ttttgataac gtgagctgtc aacggccctg gaaatatcca agagcagttt 813181 tgagtgctgg gctgtatgca agccgcttgg ttgtttcaca aatttcgtaa gccctaatcc 813241 gtaatatttt ccctgcgtca gcataagagc ggttaagctt gtcatcgtac cgtatttgtc 813301 gtaggcattg tagagctttc gcaaaatatc atcttgttcc acaaatttat cgcctgtttt 813361 tctgatgaaa atctcattgt cactcagctt agtgacgagc gcctttcctg agctccacgc 813421 atcgcccact ccagaaaaac agctgctgta gcggggatcg cattgcaaaa tcatctgccc 813481 cagctccaca tgcaggtcct tatatttgtt ttccatatca gttaattcag tgactacatc 813541 atttgcaagc tgttcgagct tatccggatc aactgcaatg tttcctgaca caccgttcac 813601 ctcccgagtt tatgtctttc ctctcttgct ttacgctcca gttcttccat tctggcaatt 813661 tcagcttttc gttcttctat tttgacagcg gcagccttca gctcttggct tgtttcaagc 813721 agctcctgtt cgaattgatc gtaggcggct ttcgtttcct cgaaatcctg gtcaaacgaa 813781 tctcttgctt tgccctgcca agcatctccc aatgcagata accgggattc aagcagcatt 813841 ttggagcttc tgacctcttc tgcggccgca ctatacttgt ttgccagctc aatgacttta 813901 tatgagtcca acttttgtcc cctgcctttt ctaaattcac gcacaattgg atgttttata 813961 taaatgatta taaataattc ggcatgtatc cgaatcgtac aaaagaacct tttcataaga 814021 attggaaggg cgtatattca cttaaaattc acagttggtg agactttaag attacaaaaa 814081 aggtaaaaaa accaaatctc tcagacataa ggcaaatgag aaatttcccg ctctatggga 814141 aaaaacacta aagttgatca aatgacctaa gtgcgccaaa cgtgttacgg gacgagctat 814201 ctcatggtat aaatggaatt gtaaacgtta tcaaggaggt cgtcatatga agaaaaaatc 814261 attctcaatc gtaatagcgg gcggagggag cactttcact ccagggatcg tactcatgct 814321 cttggaccat ttggaggagt ttccgatcag aaagctgaag ctgtatgata atgataagga 814381 gagacaggat cgaattgcag gcgcctgtga cgtttttatc agagaaaaag cgccggatat 814441 tgaatttgca gcgacgactg acccggaaga agcttttaca gatgtcgatt ttgttatggc 814501 gcacatcaga gtagggaaat acgcgatgcg cgcgcttgat gagcaaattc cgttaaagta 814561 cggagttgtc ggccaggaga cgtgcgggcc gggcgggatc gcatacggta tgcgttcgat 814621 cggcggtgtg cttgaaatat tagattacat ggaaaaatac tcgcctgatg cgtggatgct 814681 caattattcc aatccggcgg caattgtggc tgaagctacg agacgcctta gaccgaattc 814741 taaaattctc aatatctgtg atatgccggt tgggatcgaa gaccggatgg cgcaaattct 814801 tggcttatcc tcaagaaaag aaatgaaggt ccgctattac ggattgaatc atttcggctg 814861 gtggacatcg attcaggatc aagagggcaa cgatttaatg ccgaagctga aggaacatgt 814921 atcccaatac ggttatattc cgaaaacaga ggctgaagct gtggaggcaa gctggaatga 814981 cacgttcgcc aaagcgcgtg acgtgcaggc tgcagatcct gacacactgc cgaatacgta 815041 tttgcaatat tatttgttcc cagatgatat ggtgaaaaaa tcaaatccga atcatacgcg 815101 ggcgaatgaa gtcatggaag ggcgcgaagc ttttattttc agccaatgtg acatgatcac 815161 acgtgaacag tcctcggaaa acagcgaaat taaaatcgat gaccacgcat cgtatatcgt 815221 tgatcttgcc cgggcgattg cctacaacac aggtgaaaga atgctgttga ttgttgaaaa 815281 taacggtgca attgcgaact ttgacccgac tgcgatggtt gaggtgccat gcatcgtcgg 815341 ctcaaatgga cctgaaccga ttaccgttgg caccattccg caattccaga aagggctcat 815401 ggagcagcag gtatccgttg agaagctgac tgttgaagcg tgggcagaga aatcgttcca 815461 aaagctgtgg caggcgctga tcctgtcaaa aacagtgccg aacgcgcgtg tggcaagact 815521 cattcttgag gatttagtgg aggccaacaa agacttctgg cctgagcttg atcaaagccc 815581 aacccgcata tcataaatga aattccccca ttttcgaatc tgtaattgta tataatagaa 815641 agaaaatggg gggatctgat atgcagctcg aagaactgat caatcagcac tacagcaaat 815701 tgaatgacaa cgattttcat attttaaaat atatattgaa tcataagcac acatgctatc 815761 accttggaat cgacgcgctg gccaaagctt gcagtgtatc gcgttcctca attttacggc 815821 ttgcccaaaa gctcggtttc agcggttaca gtgaatttcg cgtcttttta aagtgggaag 815881 atcagccgga agaaggcgag agtatgagtt ttgaaaagct gcttgatgat attgaagcaa 815941 atttgaagtt tttacggaca aaggacatga cggacatgtg ccagctgatt gatgcagctg 816001 accgcatttt cgtctacggt tctggaaatg cgcaaaagat atgcgcccgc gacctgcaaa 816061 gaatgtttat tccgcgccat cgctatctta ttttgattga agacacaaat gaatttaatt 816121 tgatgcgcga tgattttaaa gtgaacgatc tgtttatcat catttctctt tccggagaaa 816181 caccggagct gattcctcag gcaagaatgc tttctgcaaa gggtattccc tttatttcca 816241 ttacgaattt aaaaaacaat gtcctcgccc agctgactcc gcataatctt tatgcgacaa 816301 gcaaacctgt gacattaagc gatagaacgg aaattgtcgc ttttgcaccg ttttttctcg 816361 ttggcgaagc attgttccgc gcatatgttg attacaaaga ggcagaaaaa aatgacaatg 816421 agtagcaggg ggttctggta tgatgcaaaa aattcagcgc tttggaagcg cgatgtttgt 816481 gcctgtttta ttattcgcgt tcgccggcat tatcgtcggt atcagcacgc tctttaaaaa 816541 taaaaccctc atgggaccgc tcgccgatcc tgacggtttt tggtatcagt gctggtatat 816601 cattgagcag ggcggctgga ctgtttttaa ccaaatgccg ctcttattcg ccattggcat 816661 cccggttgct ttggcgaaga aagctcaggc acgcgcctgt ttggaagcgc ttactgtcta 816721 cctgacattc aactattttg tcagcgcgat attgacggta tggggaggag catttggcgt 816781 cgacatgaat caagaggtcg gcggaacgag cgggttaacg atgattgcgg gcataaaaac 816841 gctcgatacc aacatcatcg gagccatctt tatttcttcg attgtcgtct ttttgcataa 816901 tcgctatttt gataaaaaac tgcccgattt tctcggcatc tttcaaggct caacatatat 816961 cgtgatgatt tccttcttta ttatgatccc aattgcgttg gctgtgtctt atatttggcc 817021 gatggttcaa tcgggaatcg gctcgcttca aagcttcctg gttgcttctg gggcggtggg 817081 cgtttggata tacacgtttt tggaacggat tttaattccg accggccttc atcactttat 817141 ttacacgccg tttatttatg gcccggctgt agcggaaggc gggatcgtca cgtattgggc 817201 acagcatctc ggcgaatatt cgcaaagcgc caaaccgctg aaggagctct ttccgcaagg 817261 cggattcgcg cttcacggca actcgaaaat cttcggtatt ccgggtatcg ccctggcttt 817321 ttatgtgaca gccaaaaagg aaaagaaaaa actcgtcgca gggctgctga ttcctgtcac 817381 actgacagcg attgtcgccg gtattacaga gccgattgag tttacgttct tattcatttc 817441 acctttctta tttgcggttc acgccgtgct tgccgccaca atgtcgacag ttatgtatat 817501 ggccggcgtc gtcggaaata tgggaggcgg actgattgag gcggtaacct tgaactggat 817561 tccgctcttt ggcagccacg gtatgacata tgtgtatcaa attttgatcg ggctctcgtt 817621 tacagcaatt tattttttcg tcttcagatt tttaatcctc aaattcaata tcgctacacc 817681 aggacgggaa aaggatgaac agcaggaaac aaagctatat tcgaaaaagg aatacagaga 817741 acgaaaaaac aaggatgaaa cggcctccgc tgctgaaacg gctgatgaca ccgcttttct 817801 gtatattgaa gcgctgggcg gaaaagacaa catcactgaa gtcacaaact gcgccacccg 817861 cctcagagtc agtgtcaagg atgaaacaaa ggttgaaccc gacagcgtat tccgcgcgct 817921 tggcgcacac ggcgttgtca ggaacgggaa ggcgtttcag gtaattatcg gattaagcgt 817981 gccgcagatg cgggagcgtg tggaaaaaat attgaatcaa taaagactgc cctccttttc 818041 gggagggttt tcgtttgccg tcaaaaagac cgccatagta aagtaaagaa agagacaatc 818101 gagtaaaaag gggtttggag gcttttacat gcaaaaggct ttgtcgtttt taaaaccata 818161 ttcattgctg gcgggaattg ctctgattct tatgctgacg gagcttgcag ttgaactgat 818221 gcagccttta ttgattgcaa aaatcatcga cgatgggata ttgaagcaag atctgcggca 818281 tgtatggata tggggcacgg tcatgatcgg gctgaccgtg ttatcctttg cggcggggat 818341 gctgaattcc ttttatgccg cccatgtcag ccaaagcttt tcctatgata cgagaaaagg 818401 gctttttcaa aaaatccagt ccttctccta ttccacattt ggacagtttt cgtcctcttc 818461 ttatattaca aggctgacaa acgacgtcac acaggttcaa aatatgattt ttatgagttt 818521 gcggtttatg ctgcgggctc ccttaatgat tgcaggcggc attgtgctgt cgcttgccgt 818581 taatgtgaaa ctcgggtttt ttctgcttgt gaccattccg atcctgatct tgtttttgct 818641 atgggtatta aggaaaggcg gggcactgtt ccgctcagtg cagaaaaggc tggatcaagt 818701 gaacaccatc atgcaggaaa atttaattgc aatcaagctg atcaaagcgc tgcttcgcgg 818761 cagccacgaa gtcaaacgat ttatcaaagc caacacaagg ctgatggaaa aaacggtttc 818821 ggcctttcag cttgtggaat tcacgatgcc tgtactgatg ctgctgatga atctctgcat 818881 ccttttgatt ttgtgggcgg ggtcctacag tattacgagc ggaagcactc aggttggcga 818941 tgttgttgcg ataattaact acgcaacacg aattacaggc gcgctttcga tgtttccgtt 819001 tttgattatg attttcaccc gggcgaaggc ttcaggggat agaatcggtg aggtgcttga 819061 aacagaaggc gacgagcggg aggaaggcac catatctgat cgtttgtcag gacggattga 819121 gtttcagcat gtatcctttc gctatcctga aatggacaga gaagcgctca ggaatgtctc 819181 attttccgca aagccaagag aaacgatcgc gattctcggt gcgacgggct cgggcaagtc 819241 cacgcttttt cagctcattc cgcggcttta tcagccggat tcaggccgca tttacataga 819301 tgaaaagccg gttcaagata ttccggctga agggctgcgc aggcaaattg gatatgtacc 819361 gcaggaagtc ctcttgtttt ccggcacaat caaagaaaac atcgcttggg gcaaagaaaa 819421 tgcttcacta gatgaaataa tggatgcggc aaaacttgcg caaattcatg aaacgatttt 819481 aaagctccca aatggatatg acactgtttt ggggcaaaga ggcgtcaacc tgtccggcgg 819541 ccaaaagcag cggatttcca ttgcgcgggc gctgattcga aaaccggcta tccttctatt 819601 agatgacagc acaagcgcgc ttgatctgca aacggaggcg aagctgcttg aagcaatcag 819661 cacataccat tgcacaactt tgatcattac acaaaaaata accacggcga tgaaagctga 819721 tcagattttg ctgcttgagg acggcgaact gattgaaaaa ggcactcaca gtgagctgct 819781 ttctgaatct cagttataca agcgcattta cgagtcacaa ttcggaaggg aggggagcga 819841 gtcatgctaa aagacatccg caagcctttc caatatccca aactgccaat tgacaaaaaa 819901 gaaggcgcga aaaagcgggc gaaagcaaag gatacaaagg gcacactgag acgaatctgg 819961 tcttacttgg ctgaaagaaa aggactgctc atacttgtca tgctaatggt tgtcatcagc 820021 gccatattcg gactccttgg tccctttgtg atcggaaagg ccatcgacca ttttatcgtc 820081 gggaaaacgg tcagcggctt gattcctgtt ttgcttcttc tgctcgctat ctatatcatt 820141 cagtccctgt cgctttggtt tcaaaactat tggatgatta cgatctcgca gggcacggtt 820201 ttcagaatga gaagcgaatt gttcacccat ctgcatgagc tgccgattcc attttttgat 820261 aaacagcggc acggcgagct gatgagccgg gtgacgaatg acatcgaaaa tgtcagttct 820321 accttaaaca cgtcagtcat tcaaattttg tcaagtgtga tcacctttgt cgggacgatt 820381 gcggtgatgc tgtacatgag cccgctcctt actttgatta cgctgaccat tattccggtg 820441 atggcagcga gcctgaaatg gatcaccaac cgaacgggaa agctgtttaa agaacagcag 820501 aaaaaccttg gtgatctgaa tgggtatatt gaggaatctg tttcaggcgc aaaggtcatc 820561 aaagcatatt cacgtgagaa gcagattact gctgaattcc tcgaaaaaaa cgctgcactc 820621 aagacgtcgg gcttttgggc gcagacgatt tccgggttta ttccgaaggt catgaactct 820681 ttgaataact taagctttac aatgattgcg gcaatcggcg gtttgtttgc gctgaaaggc 820741 tggatctcga tcggctccat cgttgtcttt gccgagtatt caagacaatt tacacgccct 820801 ttaaacgatc tggccaacca gtttaatacg atgctgtccg caatcgccgg cgctgaacgg 820861 gtgtttgacg tgcttgatga aaaagaagag cgcgaggatg aaaagaacgc cgtgcatcag 820921 cccatccaaa caggcagcat tgaattccgg gatgtgtcct tcggttacga taaagggcag 820981 cagacactga agcatttaca gtttaccgtg cctgcggggc agtccatcgc gtttgtagga 821041 ccgacggggg cggggaagac aaccgtcact aaccttctcg cccgttttta cgagcctaac 821101 gatggaaaaa ttttaatcga tggtacagat attaaaaccc ttactagagc aagcctaaga 821161 aaaaacatgg ggtttgttct tcaggattct ttcttatttc agggaacgat cagagaaaac 821221 attcgctacg gcaggcttga tgcttctgat caggaagtcg aagccgctgc aaaaacagcg 821281 aatgcccata gttttattga aaggctgcca aaagggtatg acaccgtact gacgcaaaac 821341 ggttcgggca tcagtcaagg gcagaagcag ttgatttcta tagcgagggc ggtgcttgcc 821401 gatccggttc ttctcatttt ggatgaagcg acaagcaaca ttgataccgt tacagaagtc 821461 aacattcaag aagcgctcgc ccgtttaatg gaaggaagaa caagcgtcat cattgcccac 821521 aggctgaaca ccattcaaag agcggaccag attgtggtgc taaaaaacgg tgaaatgatt 821581 gaaaaaggca gccatgacga gctgattcgg caaaaaggat tttacagtga cttatatgaa 821641 agccaatttg agaaatagac ctttgtcctg cacagaggtc tttttttgtt acagttttat 821701 agtactttta tttcattttc gtaaaatgta acaaaattac ttgacgtaaa caagttatgt 821761 atatatacta gcttacatta agtaagtgat aacatttatc aaggaggata aaatgaataa 821821 atcatttgaa attggcacat tacttttaag agttattaca ggtattatct tttttgttca 821881 cggtttatca aagtttcagg gaatggaggg caccatccaa tttttcggca gcataggcct 821941 tccaagcttt atggcgtatg tcatcgcagc gattgaactg attggcggag tgcttgtctt 822001 cttcggattg gctacacgta ttgtcggtgt actgttcgct cttacactga tcggcgccat 822061 catcactgtt aagctgaaag cgccattcat gggcaatgca gaatttgatt accttctgct 822121 tttgacatcc attcacctgg cgcttactgg aagtcgattc ctggcgctgg acccatttgt 822181 gtttaaagga aaaaagaacg gaaacgtttc agcataagaa aagaggcatg cagcatgacc 822241 agcattcatg aggatacaca cattggctat gccaaactca caattcgcag tctggagcgt 822301 tcgcttcagt tctactgtaa cgtcatcggt tttcaagtct taaaaaagac ggaccgccaa 822361 gcggaattaa cggctgacgg gaaacgcgta ctgcttattc ttgaagaaaa tccgagcgct 822421 gtcgtcttgc ctgaacggtc tgtgacaggc ctttatcact ttgcgattct tcttccggac 822481 aggaaagaac ttgggatcgc gctcgcccgc ctgattgaac acggcattgc tatcggacat 822541 ggagaccatg ctgtcagcga agcgctctac ctgtctgatc ctgacggaaa cggcattgaa 822601 atgtacgctg accgcccccg cagcacgtgg cagcgtgatc gggaaggaaa ctacgtcatg 822661 acgacaaccg ctgttgacat tgagggcctt ctggaagagg caggagatga gcggaaaaca 822721 tcgcttccga acgatacaat catcggacac attcatctgc atgtcagtga tttgaaagaa 822781 gcaaaggcgt tttatacaga tgtactgggc tttgacattg tcggaaacta tgcgggcatg 822841 tccgccctct tcgtttcagc cggggggtac caccatcata tcggcttaaa catttgggcg 822901 ggaagaaatg cgccgcctaa accgacaaat gccagcggac tagattatta tactgttgtc 822961 ctgccccacc aagaggagct ggatttggtg gcaaaccgag tcaaacatgc cgggtattcg 823021 attgaagaga cggaaaacag ctttcgtgtg aaagaccctg tttccggcgc ctatattaca 823081 tttgtgattt aactgcaatc cccttgccga aataacggca gggggatttt ttatttttgt 823141 ccgccttgtt atgatgagag aaccaacttg ttaggaggcg tttacatgga actcaaccac 823201 cttgtgacgg gcaaaatagc attaaatcaa tatgtgcatc gcttagagca aaaggatgtt 823261 tcattttacg tccactactg gggagcgatg acgaaccact ataacacact gcttcataag 823321 cattcctttt atgaaatttg ttacgtggta agaggtgaag gatattacct tgaaggcgat 823381 cgtacatatc cgcttcgtga acagacgatt tttttgtcaa agccggagca tttgcaccaa 823441 atcaaaagtg aaacagggct gttccttttt tacgtcgctt tcgagctgag cgaggatcag 823501 tcaagcgccg aatggatcaa agtgatggaa gaagtgaaac aaagcccctt tatcacaatg 823561 caattgaaag atggcgaacc gccgggcctg ctttggaaaa cgttaatgct gcaagcagcg 823621 caacctgtca atgcttttga caaagagatc ctatctcatt tgtcgcatgc attgatcctg 823681 tcattaatcc aaacctttct cccgtacgcc caacgcccga aacaaaagca gcccattcac 823741 acatcttctg ctttgctgac agaggtgaaa ctgcacataa aagacaatct gtcacagccg 823801 ttaaagctga cggatgtcgc tagccacttt catatctcag ggaggcattt atcacgttta 823861 tttgcagcag aactgggcgt cagctactca gaatttgtcc aaaatgaaaa aataaacaaa 823921 gctgccgaac tgctgaaatc aacgaatttg tcgattaaag aaatagcgga agaaatcggt 823981 ttctcagtac attatttcac tcgcgtcttt tccgctaaaa tcggcagctc tccagggctt 824041 ttccgctccc tttataaaga ctcaaaaatg accgcatttc aaatcaataa accttttcaa 824101 aaaatcgaac aggccaagcc gcacgaataa gatgtcctga aatgacaaaa caatgtcttc 824161 atatgataaa gacgcgagaa atctcgttgt cttataatct ttttagaaag cggttacaac 824221 aaggggtatt gctgaaggag ggatgcattg gcttatgctt ggtgtcgggt gctctgccat 824281 tcttgaaaga aggggaagaa agccgtgagt acaaaaaaga aagaggctgt aataggaaaa 824341 gaaagcttag ctcataaagg gcttttacga acgattacat tggtatctac attcggcggc 824401 ctgttgttcg gttatgatac gggtgtcatt aatggggcac ttccttttat ggcaactgca 824461 ggtcagctga atcttacacc tgttacagaa ggactggttg cgagttccct gcttctcggg 824521 gcagccttcg gggcgatgtt tggaggacgt ctgtccgatc ggcacggccg ccgaaaaacg 824581 atcctttatt tagccttact cttcatcgca gccacacttg gctgtacctt ttcaccaaac 824641 gcgtccgtga tgattgcctt tcgttttctg cttggactgg cggttggctg cgcttctgta 824701 acggttccaa cctttttagc ggaaatttcg ccggcagaac gcaggggacg aatcgtgaca 824761 caaaatgaac tgatgatcgt aattggccag cttctggcat acacctttaa cgccattatt 824821 ggcagcacaa tgggggagag cgcaaatgta tggcggtata tgctggtcat cgcgacactt 824881 ccggctgttg tgttatggtt cggaatgctc atcgtgcctg aaagcccgcg ctggctggca 824941 gctaaaggca gaatgggtga cgccctgcgg gtgcttcggc aaatccgtga agacagtcag 825001 gcacagcagg aaataaaaga aatcaaacat gcgattgagg gcacagcaaa aaaggccggc 825061 tttcatgatt ttcaagagcc gtggataagg cgcattctat tcattgggat tggaatcgcc 825121 atcgtacagc aaattaccgg tgtcaattcg attatgtact atgggacaga aattctgaga 825181 gaagccggtt ttcaaacaga agctgcatta atcggcaata ttgcaaacgg tgttatttca 825241 gttattgcgg tcatttttgg gatatggctt ctcggcaaag tccgtcgccg gcccatgctg 825301 atcatcggac agattggcac gatgacagcc cttctgctga tcgggatttt atccattgtc 825361 cttgaaggaa cacccgccct gccgtatgtt gtgctgagtt tgaccatttt gtttcttgcg 825421 tttcagcaga ctgccatttc tacggtgacg tggctgatgc tctcggaaat ctttcctatg 825481 catgtgcggg ggcttggcat ggggatcagc accttctgct tgtggacagc taactttctc 825541 attggattca cctttcccat tttgctcaat catattggga tgtcggcgac attttttatc 825601 tttgtcgcta tgaatatcct agcgattcta tttgtgaaaa aatatgtgcc tgagacaaaa 825661 gggcggtcac ttgaacagct tgagcattcc tttcgccagt atggccgccg cgctgatcag 825721 gaaatccaaa atcaaacaac tcacttatcg taacctgaga taccaggagg aatctatcaa 825781 tgaaactatc ttatgtaaca gacagcctag ggcatttgcc ttttgaagac atgctcaatt 825841 ttgccgcaaa gcttgggatc gatacacttg aaatgacaac cgggggctgg tcgccggcac 825901 ctcacttgaa tcttgatgaa ttgctgcaaa gcagcgaaaa aagaaaagaa ttttcacaag 825961 cgctggaaaa gcggaacatg acactttgcg cattaaactg ctcggggaac cctttagatc 826021 cgggtgaatt gggcaaatcg cacagagaca taactgacaa aacgatggag ctggctggat 826081 tattaggcgt caaaaaagtg atcatgatga gcggtttgcc agccggcggc ccggacgaca 826141 aagtgccgaa ctggatcaca tacacagtaa gctggcctcc cgttttaaaa gatatcctca 826201 actatcaatg ggaagacgtt gcgatcccat attggaagaa gcttgtcaaa aaagcggagg 826261 cctgcggcgt ggggaaaata gcgcttgaga acttcagctc tcaattagtc tataatcctg 826321 agactctctt tcggctcaga aatgcagtcg gcccgatggt cggtttgaat cttgacccga 826381 gccatttgtt atggatgggc gcagacccga tcatcgcagc aagggagctc ggctcagcca 826441 ttcaccatgt ccatgggaaa gatgtcagaa ttgaaagata tttatcggcg gtcaacggac 826501 ttttagaaac aaaagaagtg acagatcctg caaaccgggc gtggaattac gtagctgtcg 826561 gctgtggaca ggatttacag tggtggaagg aatttttttc agttgtaaaa atgatgggat 826621 atgaaggtga ggtttcttta gaaatggagg atctgacgat gtcacctgaa gcgggcatcc 826681 gtacttctgt agaagcttta aaacaaacca tcagccaata ggaggttttc atgatgctaa 826741 atggagaaag aatcatctct aagccgcttc gctgggcaat ggtaggcggc gggcggctca 826801 gccaggttgg atataaacat cgtattggag cgctgagaga caatactgct tttcaattaa 826861 ctgctggcgc ttttgatatc gatgccgaaa gaggaaaaga tttcggggtg aaccttggag 826921 tggatgcgga acgctgttat cccaactatc aaaccatgtt tgccgaggaa gcgaaaagac 826981 aggatggcat agaggtagta tcgattgcca ctccgaacgg cactcattat gagatttgta 827041 aggcggcgct tgaagcagga gtgcatgtca tctgtgaaaa accgctgttc ttcacttcag 827101 cagaggggca ggaaatcaaa gcgctcgcag agaaaaaagg gaaaattgtc ggcgtgacgt 827161 acggtttttc aggcaatcaa atgcttcttc aaatgcgtgc gatgattgaa caaggaatga 827221 tcggcgatat tcgcgtggtt gacttgcagt acacacacgg tttttgtgca acagatgaag 827281 gtgaaaagat aagcgctgca cagaaatggc gtgtcgaccc tgcgatcgcc gggccaagct 827341 ttgtgctggg cgatttatct acccacacgt attatatgtc acagcttatt atgccaaaga 827401 tgaaaattaa ggagctgctg tgtgaccgac agagcttcgt cggcagccgc gcaccgctag 827461 aggataatgc ccatgtgctg atgcattatg aaaatggagc ggtcggaacg atgtggacat 827521 cgtcaatcaa tgccggatgt atggatggcc atagaatccg gattgtcggc tcaaaggcaa 827581 gcattgagtg gtgggacagc aagccaaatg aactgacgta tgaagtgcag ggagagccgg 827641 gccagacact cgttcgcggc atgccgtatt tagatgatgt ttgcaacgcc gatgaacgac 827701 tgggcgcctt acacagcgaa gggctgtccg aagcatgggc caatatttat cttaaatttg 827761 ccattgcgat agacgccaaa aaccgtgaag atgaagaaat cttgaacaac ttggtttatc 827821 ctgacattga tgcagggatc gagggcattc gctggattga gaactgcgtg cgctcggcaa 827881 accaagggtc agtttgggtt gaatttaaat aaatgaggga atgcgccgca tatgacataa 827941 agttcatatg cggtttttat tttccagaaa ctcctgtcaa aaatgccctg aggcaggtat 828001 gataagaagg gaattgggta tcgggagtga tgagcgtgaa agctcttttt tttacgagaa 828061 tgttcacctt gatggtgagc tgtttaatgt atctgtccat tgtgaaagag gataactggt 828121 ttggatatgt atttatagca gcaggtgctg ccatgtatgc agccaatcat gttttgctga 828181 caaaagagac aaatgccatc tggttctgcc tgattgatat tgcaatcggc ttttcgttcg 828241 gatttatctt tcccggcaca ggtttgttca ttattatgct ttgtccggtt gcggtcgcct 828301 tttttctgcg ggggtttcct aaaagaacag catggtctgt cttatgtctt tcctctattt 828361 tatttttgac cgtcctcatc cgtacatatg cgatgttcgg caatgaattt gtcattgatc 828421 atttgactag catgacattc gttgtcttct gcggtgtcgt gggcaaatta atccgcaagc 828481 tgttggatgc gcaggatacg gcaaaacagc agtttcagga actgacggag tcccatctgg 828541 cgctgtctgc tgcacatcag gagctccatt tatatgcgaa gcaggttgaa gagctgactg 828601 ccatttacga gcggaacaga atggcgcgtg aaatccatga tacagtgggg cataaaatga 828661 cggcccttct cgtccagctg cagcttttgc gtgaatggca aaaaagagac agccaaaaag 828721 cggatgagac agtaggtgtc tgtgaaacac ttgcccgtga agcgcttgat gatgtccgct 828781 tatcagtacg cactctgcaa actgaaaacg atccttcgct aatcgaatcg ctgaaacagc 828841 tgacagagga cttttgcaaa aatgcaggag tcacaacaga atttgcggtc agcggtgatc 828901 ctgcaatcat cccgctgtct ctccatccga ccctgatcag aacggtgcag gaagcactga 828961 ccaatgccaa acggcacggc ggcgccgcag cctgttcgat acagcttgcc tgcacaacgg 829021 acagcatcag ccttgtcatt aaggatgacg gcaaaggcaa tcctgaggca gcacttggtt 829081 ttggtctctt gaatatgaaa aagcgggcag cggagcatgg cggaatgatc cgctttgaaa 829141 gcgaacggga tcaaggattt actgtaaatg cagaattttc acttgccaat aaaaaatgga 829201 gcttcgggcc cgtgcagcaa aaggagagtt tatcatgatt aagatcatca ttaccgacga 829261 tcaggatatc gtcagagaag ggctggcatc cctgctccag ctccgagaag agctcgatgt 829321 gatcgcaacg gcgcgaaacg gacaggaagc cttcgaaaag gcgaaagagc tggagccgga 829381 tatcgtgtta atggacatcc gcatgccggt ttccaacggg gtggagggaa caaaattaat 829441 cacaagctcg ctgccaagcg taaaggtttt gatgctgaca acctttaagg attcagcgct 829501 gattgctgaa gcgcttgaag agggagcaag cgggtatctg ctgaaggata tgtctgcaga 829561 tacgattgta aaagcagtga tgactgttca ttctggcgga atggtgcttc cgccggaatt 829621 gactgcccaa atgctgaatg aatggaagcg tgaaaaacag ctgaaaggaa taaatgagat 829681 agaaaaacct aacgagctgc tcgacctgac cgagcgcgaa atcgaagttc tggctgagct 829741 gggatacggg ctgaataaca aagaaattgc cgaaaagctt tacattacag aaggcacagt 829801 caaaaaccac gtttcaaata ttatcagcaa gctggctgtc agggacagaa cccaagccgc 829861 catttactcg gtcagatatg gtgtatctgt cttttgacat atgacgtttt gcatatacgc 829921 ttctctgaaa aggcctttta caggcctttt tttcatgccc tatgttctat ctgccgctac 829981 atgccgcacg cctttctttc ttctacaatg gcaatggatc aaaaaaagga gtgagacgac 830041 gtgctgcaag cagaaaacat caaaaaggca tacggaaaaa aaacaatcgt gaaaggcatt 830101 tctttttccc tcaaaaaggg ggagtcgttc ggtctgctcg ggcctaacgg tgcggggaaa 830161 tccacaacca tctcgatgat ttccggcctt gtgccgcatg acagcgggaa catcacggtg 830221 ggcggctatg ttatcggaaa agaaacggcc aaagcgaaac aaaaaatcgg cattgttccg 830281 caggaaattg cattatatcc gacgctgacg gctcatgaga atcttatgtt ttgggggaaa 830341 atgtacggac ttacgcacgg tgaggccaaa aaaagagcgg ctgaggtcct tgaatatgtc 830401 ggtctgactg agcgggctaa agataagatt gaaacatttt ccggggggat gaaacgaaga 830461 atcaacatcg gtgcggcttt aatgcataag cccgagctgc tgattatgga tgaaccgact 830521 gtcggtattg accctcaatc gagaaatcac attttagaaa cggtcaaaca gctcaacgaa 830581 acgggcatga cggtgatcta tacgagtcat tacatggaag aagttgagtt tttatgcgac 830641 cggatcggga taattgatca gggggaaatg attgcgattg gcacaaaaac tgatttgtgc 830701 agccgccttg ggggcgatac catcattcag ctcacggtca gcgggatcaa tgaagcgttt 830761 cttgtggcga tccgatctct ggcccatgtg aatgatgtaa cagtacatga attagagctc 830821 aaaattgaca tttctgcggc tcatcatgag aaagtcgtca caagcctgct tgctgaagcc 830881 actgctcatc atataaacct gctgtctctt caggtgcagg aaccgaatct ggagcgcctg 830941 tttctgaatc tgaccggccg cacgttgcgg gattgaggag ggacggcaat gaaaaaaagc 831001 atatggatcg catggaaaga tgtgaaaatc agaatcacgg acagaaaagg gtttatgatg 831061 cttatcctaa tgccgctcat cctaacctgt attttaggcg cagcgctcgg atcagttgtt 831121 gacggaggca gccggattga tgatatcaaa gtcggctaca ttcaatcaga ccagtcagat 831181 acagcaaaca tgtttacaaa agatgttctc aaaaaaatga agtcgataaa ggtcacaaaa 831241 gtcggcagca aagacaagat gaaaaaactg attgatgaaa agaaaatcga tgtaggcatc 831301 gttatcccga accattggga agccggcaaa acctcagctg ttgttaatgc cgctcctgat 831361 caaacattga aaagttccat cattgaaaca gctgcaagct catttataga gcaatataaa 831421 gcggtaaagg aagccgcgtc aggctcaatg gactacatca gtaaaacgga agctgtaaag 831481 caaggaaaac ttgaccctgc acagtttgca gaaaagctgg caaagacgct agaaaaagaa 831541 acaggtgaca agcttactat tgcggaaaaa tctgtcggca gcaaagccgt taccagtttt 831601 caatactatt cggcggcaat gctttgcatg tttatgctgt ttcatatcac agtcggggcg 831661 aaatcatttt tacaggaaaa ggatacggag acgcttgcca gaatgctgat gacgcctgcg 831721 caaaaatccg tcattctctt cggaaaatgg cttgggacgt atctgtttgc catcatacaa 831781 tttttcatat ttctgatcgt cacaatcaac gtatttggtg tggactgggg cggtaatctg 831841 ctgttagtga gtgtactcgg gctttcttac gccgcagctg tatctggtat ttcaatgctg 831901 cttgcgtcgt gcatcagcga tatgaaaact gcagatgcga taggcggctt cggcattcaa 831961 ttgcttgcgg ttctcggcgg gtccatgctg ccgctgtacc aatttccgga cgtcttgcag 832021 tctgtatcca aagcggtgcc aaatcgctgg gcgcttgacg gctttctttc tttaatggaa 832081 gggggaggct gggctgacct tcaaaagcct gtgcttcttt ttgcggcgat cggcttttgt 832141 tcacttgtaa ttggtatcag acggcttcat acaagataag gaggtacaaa aggtgaaaaa 832201 aattctagcc atttgcggca ttgagctttc tctcattttt aagaagccac agaactattt 832261 gatcatgttt gctgccccgc ttttgcttac ctttgtattt gggagtatgc tcagcggcaa 832321 tgatgataag gtgcggcttg caatcgttga tcaggacgat acgattctct cacagcatta 832381 tattcggcag ctgaaggcac acgatgatat gtatgtattc gaaaacatgt ctgaaagcaa 832441 agcgtcagaa aagctgaaac aaaagaaaat tgccgggatc atcgtcattt cccgctcgtt 832501 ccagacacag ctggaaaaag gcaaacatcc tgagctgatt ttccgtcacg gccctgagct 832561 gtcggaagcg ccgatggtca aacaatatgc agaaagcgca ttggcaacgc tcaatattca 832621 ggtgaccgcg gcaaaaacgg catctcagac agcgggagag aactggaagg cggcgtataa 832681 aacggttttc gccaaaaaac atgaagatat agttccggct gtaacacgac agacgctcag 832741 tgataaaaaa gagggtgcgg aagcaagtga cacagcctcc agagcagcag ggttttccat 832801 cctgtttgtc atgctgacca tgatgggagc ggctggaacc attttagaag caagaaaaaa 832861 cggcgtatgg tccagattgc ttacagcctc tgtcagccga gccgaaatcg gtgctgggta 832921 tgtgctgtcc ttctttgtca ttggctggat tcaatttgga atattgcttc tttccaccca 832981 ttggctgttt ggcatcaact gggggaatcc ggctgcagtt attgtattag tgtcactttt 833041 tctattgacc gttgtcggca ttggattgat gattgcggcc aacgtcagaa cgccagaaca 833101 gcagcttgcg ttcggcaact tgtttgtcat cgcaacatgt atggtgagcg ggatgtattg 833161 gccgatcgac attgaaccga aatttatgca atccatcgct gaatttcttc cgcaaaagtg 833221 ggcgatgagc gggttgacag agattatcgc taacggtgcc cgcgtcacag atattctcgg 833281 aatctgcggc attttgcttg catttgctgc gatcactttc gcagcggggc tgaaagcgct 833341 ccgagcctaa aaaacatctg ccgtttaggc agatgttttt ttgcatgtgg gtacattcgt 833401 atgggtgcag cctgaactgc ggttaatcct tatctatcat agctaaaatt gattccagcc 833461 aagaaacgta atttttctcc cgctccagcg ctttcgttag cacaagatag tggccgaagt 833521 ccggtgaaga aaatgacatc ggctctgctg aagccataag cttttcatag cttccctgta 833581 agtcagaaag cttggcctgg cgtttttgca gctggtcttt gaacaaatca gaagcctcct 833641 ggcgcgatag acaagaaatg aaataagcct tcagcataaa ttcatccttc accgtctcgg 833701 gtatcggctg gtggcggatc agccagtcat gcagctcctg ctttccgctg tctgtcaggg 833761 tgtacatctt tttctccagc tttgtgccct gaatcgttgt ccggaacgtg ataaatcctt 833821 catccgtcag ctttttgagc tcagggtaaa tctggctgtg cttggcgctc caaaactggc 833881 cgagctcctc tttaaaataa ctcgtaatat cgtatccact caattcgcct tttcgcaaaa 833941 gccctaatat ggcgtatttt aatactctca tgctatcctc cgtgtctggc tgtttcgcaa 834001 aacagatgag ccggtgctca actgtgattc taactgccta ttccccttat tatagaaaag 834061 ggaggaaggg aacacaaccg ggctctttgg aaatgaagat aaaaggtttg tcagaaggta 834121 tccgatttat ctccgtcaat ataaaagaga tttaaattta attttcagaa aaaatagtaa 834181 cgatattgat tttttatata taataggaaa ttggtggtat gaaaattttt tgggggaata 834241 aacgtgaaaa aagtacttat ggcattcatt atttgtttat cgctgattct atctgtttta 834301 gccgctccgc cgtctggcgc aaaagctgag tcagtacata atcctgtcgt tcttgttcat 834361 ggaataagtg gtgcatcata caactttttc gctattaaaa actacttaat ttctcaaggc 834421 tggcaaagca acaaactgta cgcaattgat ttttatgata aaacaggaaa caacctaaat 834481 aacggcccgc agcttgcttc atatgttgac cgtgttttaa aagagactgg ggcaaaaaaa 834541 gtagatattg tggctcatag tatgggaggc gccaatacgc tgtactatat taaatattta 834601 ggcgggggca ataagattca aaatgtcgta acgcttggag gggctaatgg tttagtgtca 834661 tcaaccgcgc tgccgggcac agaccctaat caaaagatcc tctatacatc tatttacagt 834721 ctcaatgatc aaattgtcat caatagcttg tctcggttac aaggagcgcg aaacatccag 834781 ctttatggca tcggtcatat tggcttgctt tctaatagcc aagtgaacgg ctatatcaaa 834841 gaagggctga atggcggagg cctcaataca aattaatatc ttcaaaaaac aacctgctgt 834901 ctccgttaca gtgggttttt tcgtctgaga aagccatagg gtcttatgac cttagtctat 834961 catgcatacg tcaatttatg acatcaggca ctttttcaaa tagagcggac atgttaaggt 835021 acaaccatcg atttctatca atttgaaata aaaggagcgc tgttatgcaa attaaagaaa 835081 tttttatgat ccgctgcatt tcgtgcttaa gtgtcgtctt gctccatatc atttcaatgg 835141 tcctgatgct tcaggcagaa gctcttgcag atatttctca cactgttgat tctttccgca 835201 cactcctgat gttcagcacg cccgctttta ttttcatctc tgaattttta ctggcccgtt 835261 cttatcctga tggggtgcct gacggttttt taaagaagcg gggaaaagtg atttttgttc 835321 cttttttatt tatcgcagcc atcgatgcgc tgctgatgac cagtgcgatg gggggagagg 835381 taacctttct cgcgtttgtg caaaaatatc tggcgaacgt attcttagga aactttatcg 835441 gatacttcat tctcgtcatc tttcaatttt acatgctgca tatgatgttt catgagtatt 835501 tgaaaaaagc atcgccgaaa tgggtgctgt ctatctcatt tgtggtgaca gccgcttatt 835561 taggctattt ctccgcagcc agcccggctc ctgcttctga agagggaggg gcatttccgt 835621 tcttctgggt tccgttcgca ggctggcttt tctacttttg tctagcctac tattgcggaa 835681 aagaatacaa gcgtttttta gcgctgctga accaataccg ctgggtggtg tacggcgccg 835741 caattgcttc tggggcgctg gttgtcactg tttcttatgt cggtgaaatc ggcatgatca 835801 gctcgaagcg gcctgatatc atgctgtatt caacaagcat gattttcctg tgttttcatt 835861 tgttttccaa aatgaagcat gtgccgaaaa tcatgatgtt tatcagcaac tattcctttt 835921 cgatttatct gcttcatgcc tattttatga ttataggcta cgtgttgctt ttgaatatgc 835981 ccgaaattcc tgccgtaccg gctgttctcc tgttgtttgc cgtgtgcaca gccggcccga 836041 ttatgacctc atgggcgctg aataagttca aatacgggta tttatttgtg gggaaaattt 836101 atcagccaaa acagaagaag gtaacagtcg aagtgcgtga tcacgcaggg tgaaaaacaa 836161 gcggcaggag ggctcctgcc gcgtttcttt acttctcatc cgcttgcaga actgttttta 836221 aatatagttt tgcagactca gcaagtccag atacatcagc cttttcttca tcgaaataca 836281 gggcgttttg aatgatgccg tcattcatat tgaggaaaaa cttggcgata gtcgcaagag 836341 gctgaaccgg ctgaaactct ccctgatcga tccctttttg caatagcctt gaaaaccttt 836401 ccacaaaaag atcatacctt ttctccaaat actgccgccg ttcttcattg cgccaagctg 836461 tcactaaata ttcaaattgc accggcgcca gcgtatctgc tacatctcgc aggccctcag 836521 tcagttcatc caaatagctg gaaatggagg cccaaacact ttggtgttca gctgatttat 836581 caagctttcg gagtccttca tccagccctg tttcaataat gcggcgaaac atctcctcag 836641 tgcttgaaaa ataaagatag acaccgcccc ggctgaaacc tgactcttct acaacatcct 836701 tcatcgtcgt taattcgaat ccttttcgtt taaaaaccgt tttggcagcc tctaaaatct 836761 ctgcctgccg tttatccttg tgctcctttg ttacttttgg tgacaagata tcgcctgctt 836821 tctgcaattt tcttacctat aagtgtaatc aacccaatca tgatcagcaa gcagccacag 836881 acaagaaaag caagtgatac accgatccat tccgccagca cgcccccgcc cgccatgccg 836941 aggatagagg cgagggttgt cgcactctga atagcgccga acaccctacc gctgtaatcg 837001 acaggcactg ttgtttgcac gagaatctga aatggaatat ggacgaggcc gaaagccgcc 837061 cccatgatga aaaaagcaaa tataaagaga gtgatgccgg caattcccat accgcttagg 837121 aatggcgcac ctccagttgc tagtccaaga agaagggttc cagctgagaa ataaagcaaa 837181 taagaagtga ttcgccgtct gccggtaatg gccgctgtaa ggagcatccc ggctccgctt 837241 acggccatgc accagcctgc cagctcgggc ggagctcctg aaaaggagcg gataagaata 837301 atcgcttggg aatcaccaat ctgcaaaaca aagagaacga cacaagctgt tagtaagcct 837361 gttaatagaa gcggcatccg tttcaaaaac tgaaggcctt ccttgataga agtaagtgct 837421 gctgtttttt cttgaggtgt attggctttt tgtaaaaaag catctctggg aaggaaaaac 837481 aaaatgacag cggaaagaaa gaaggcgccg gcgtttatat aaaaaacaga gtgtatcgag 837541 aaagcagcga tcagcgtgcc gccaagggca gggccgaaga tttttgagct gttatcaatg 837601 atgctgctga cggaaacggc ctgctgaatg tgtgcttccg gagccaattc cttaagcttt 837661 ccgtttttag caggtaaaaa aagtgaagaa aaacagctct gaacggatag caatacgtaa 837721 agctgccaaa gctcactgac ataaacgcag ctgataacag tgagggcacg gccgatttca 837781 gatagaaaca tgatcgtttt tctgtcaaaa cggtcggcaa gcagacccga tacaggtccg 837841 agtacaatga caggcaaagc aaacgacatc attaaaagcg acatatctaa tggagaagca 837901 tgaagctgaa aagcggctaa tgttagcacg gccaaaatgt gaagccagtc tccaagtgaa 837961 gaaatggttt gcgaggctaa cagtgtcatc agtccttttt gattgcgaaa caacggtttt 838021 tccatgattc atcctcctga ttattaaaat gacactagtg tcgtttttaa ttgtatggga 838081 aaaagacaca atatacaatc tttttcttgt aaaataaagg agaagattga atagaaggga 838141 gaacattcat gacatcagtc aatctaagct acccaatagg agaatacaag ccgagggaat 838201 ccatatcgaa ggagcaaaaa gataaatgga ttcaagtact tgaagaagtg ccggcaaaat 838261 tgaagcaagc tgtagaggtc atgacggaca gccagcttga cacaccgtac cgggacggtg 838321 gatggaccgt tcggcaagtt gttcatcatc tggctgacag tcatatgaac agctatattc 838381 gttttaaatt gagcttgacg gaagagacac cggctatccg tccgtatgat gaaaaagcat 838441 ggtcggagct aaaagactcg aaaacggcag atccgagcgg ctcactcgcg cttttgcagg 838501 agcttcacgg aagatggacg gctctgctcc gcaccctgac ggatcagcaa tttaagcgcg 838561 gattttatca ccctgataca aaggagatca ttaccctgga gaacgcgctc ggcctgtatg 838621 tctggcactc acatcaccat atcgctcata ttacggagct ttccagacgg atggggtggt 838681 cttaacgctt ttgccggcgg aaagccggaa tactgatagc agcaatcacc agaagtgaga 838741 ccacagcagc cgctgcatat aaatgatcat agccgctggc gacactcgca tgaatggcgt 838801 cgcttatcgc ggttttgact tcaggaacgg gaatgcgttc gatttgttct tgtaaagaag 838861 aaacttcaga actgtcgatc tccggaatca tctgcatcgc cttttctgaa tatccgctgt 838921 ccgataagcg gctgttgatc tcatcaccta tttggtcaaa cccggctgtg ataaaacctg 838981 cataaagagt aggcgccaag gtcagtccaa tttgccttac taatgaaagc gtgccaagag 839041 ctgtaccctt atttgttttt gccgcttctg atacaaggac gttcagcgga gcgcctaaca 839101 gaaagccaaa accgatccca gctgccacac ttgcgatcac aaactcccat ttttccgtga 839161 cccagagcgg aaataaagca aaccccgcac atgagatgat tcccgaaaga ataacggttt 839221 ttacaggacc ttttttgtcg gtaagtgctc cgccaagcca agcgccgatt ccggaagcca 839281 acgcaagcgg tgtcatccaa tagcctgctt ttgcggcagg gacacccaaa tactgttcga 839341 catatgacgg gataaaaatg actgccgcca agagcccccc ggataacaaa ccgatgataa 839401 gcgtgcgctg aaacatatgg tttcgcagca gagaatacgc caaaatggga tcgcctcctc 839461 gcatttcaac tctcttttca tacgagataa gcgctgcaaa acagagtatg ccaaaaataa 839521 tacatccata aacctccgga ttccccaagc tgtgtaagag atttgccccg tcaagattgg 839581 tcatgccgta catcacagct aaaatcgaca gggacaaaag gaagattccg gccgcatcga 839641 ggcgcttagc ctcaggtgct tttgtttccg cgataaaaca tgcgccgaaa acaaccaata 839701 gcacggcaat cggcaaatta atcaaaaata gccaatgcca agacccggtc caatcaagca 839761 gaaagcttcc gatatttggc ccgagcacag cggccatccc gttcattgcg ccaagcagcc 839821 caagcgcctt cccctgtttt tcctttggaa gggtcgcgag aatgtgagag ctgccgatga 839881 tgaaaatccc gccgcctcca agcgcctgaa tcagccgcga tatcagaaag agcgggaagc 839941 tttggctcaa agcaacaagc aaagaaccaa gtccgaacag gcaaacctca atgagaaaga 840001 gtttttttct gccgtagcgg tcggaaagtt ttccgacgat tggcacactg acgctaagac 840061 cgagcgtata aagggtaatg ccccatgatc cccaggaagg ggaaacggaa aacgactcgt 840121 ttatcgttgt taaagcagcc gaaataattc cgttatctaa agcagccata aacacgccaa 840181 tcgtaaacag gctgattgcc cacttttggc ttttctgctc tgttaatgct tcagacattt 840241 tcgtcaactc cttttagttc acttgaaata tattattcat tttaaatgaa ctaaatgtca 840301 aataaaaaaa gcctgctccc gcagtttgcg gatgacagac ttactgattt attctttttt 840361 cgcattctct aatgctcttg aaaggataga cagcccttcg taaacagcct gcttttcttc 840421 aggggacagc agctctaatg aacgcttcaa tttcaggtgg cccttttcat acaaaccccg 840481 gaaaatcttt ttcgcattct ctgtcaactg aacaactaca gagcggcggt cctcttcaga 840541 atgtgagcgt ttgacaaatc ctgatttttc aagccggtca agcagcccag ttgtattgga 840601 cagggaagcc cccatttttt cagcaatgtc gctcactttc aatgttccat ggttgtttaa 840661 tagcatcagc accttcattt gcggcatgct catatccagt ttcatccact cggacacatc 840721 accgagcccg gcggacgtta agactttcat atagagcacc catatttccc gttcctccga 840781 tgaaagaatg ttttcgttta agactgttgt atcgtgtaaa ttatattcca tttcatcact 840841 tcctcatcat tcactcctct taccatatta ctcgattttc actcctgaaa gaaagtgagc 840901 agaaaccgca tgcgggactt tgtccgaaaa ataacggtag tgtataatga gttggagatt 840961 attgggggag aggatcgaac tagaatatga ttggagagac cattgctgat taaaaagaat 841021 gctttatcaa tattaaaaat cgtttttcct attgctgttt tgctatttgt tatttatcaa 841081 tcgaaaaaag aactgacaaa tctgtcattc aaacgtacgc tcatggtcat caacggactg 841141 gaacgaacgg atttattcat gcttgtgttg atcggcttgc tggctgttgc ggctatgtcg 841201 ctgtatgatt acgtcctgaa gtactcactg cgcctatcga tcacaaacgg aaaagttttc 841261 agggtttcct ggatcgccaa ttcatttaat aatgtgttgg gattcggcgg tttagccgga 841321 gtcgggttaa gaatgatgtt ctataaggag catacgaaag accataaggc actcgtgaaa 841381 ggaatcgcct ggctcacatc atctatgctg ctcggattat ctgttttcag cattttcgtt 841441 gctgcgagag tgctgccagt tgatgaagtg attcatgaga agccttggct gtgggcggtc 841501 gttatcggtt ttgcactgat attgccgtta tctttagcgg tgtccaaaat aaaagaccgc 841561 aaagctgggg acgaagagaa tgcggataaa gtgaaaaatc cgattttcgc atatattgga 841621 gcttcagttg ttgaatggct catggccggg accgtcatct attttgcttt gttcgctatg 841681 ggcattcatg cagatatcag gtatgtgttc ggggtgttcg tcattgcggc gatcggagga 841741 atgatcagcc tcgtgccggg cggcttcggc tcgtttgacc ttttattttt gctggggatg 841801 gagcagcttg gctatcatca agaggccatc gttacttcta ttgtgttgta caggctcgcc 841861 tactcattta tcccatttat cttgggactg ttctttgccg ccggcgacct gacggaaaat 841921 acaatgaagc ggctcgaaac gaacccgcgc atcgcaccgg caattgagac gacaaacgtt 841981 ctgcttgttg ttcagcgtgc ggtattagtg agaattttgc aaggctcgct ttcccttatt 842041 gtgttcgtag caggtctgat tgtcttggcc tcagtttcct tgccgattga caggctgacg 842101 gttataccgc acattccgcg cccggcgctt ttgctgttca acggcctgtc cttaagctca 842161 gcgctcattc tgctcatttt gccgatcgag ctttataaac ggacaaaacg ttcctacacg 842221 atggccatta cagcgcttgt cggcggcttt gtgttcagct ttttaaaagg gcttaacatc 842281 agcgcgatat tcgtactgcc gatgattatc gtattgcttg tgctattgaa aaaacaattt 842341 gtccgcgaac aggcatccta tacactggga caattgatat tcgctgtggc gctgtttact 842401 gtggcgctct ttaactacaa tctgatcgcg ggctttattt gggaccggat gaagaaggtg 842461 ctgcgtcacg aatatttcgt ccacagcacc tcgcatatta cacatgcaac catcatggcg 842521 atcatcattg tgccgctgtt cttcttgata tttacagtgg tctatcataa gagaacgaaa 842581 ccgatcggag agaaagctga ccctgagcgt cttgctgcgt ttctcaatga aaaaggcggc 842641 aacgcgctga gccatcttgg ttttcttgga gataagcggt tttatttttc tagcgatgga 842701 aatgcactgc ttctgtttgg gaaaatcgcc agaaggctgg tcgtgctcgg cgatccatct 842761 ggccaaagag aatcattccc gctcgtgctg gaagaatttc tgaacgaagc gcatcagaag 842821 ggattcagtg ttttgttcta tcaaattgaa cgagaggaca tggcgctgta tcacgatttt 842881 ggctacaact tctttaaatt gggtgaggaa gcatatgtag atttaaatac atttaccttg 842941 actgggaaga aaaaagccgg ccttcgggca atcaataacc gctttgagcg ggaggagtat 843001 actttccatg tggatcatcc cccattttct gatgcgtttt tggaggagct gaagcaaatc 843061 tcagacgaat ggctcggctc gaaaaaagag aagggattct cgctcggatt ttttgatcct 843121 tcctatttac agaaagcgcc gatcgcctat atgaaaaatg cagaaggaga gatcgttgca 843181 ttcgcaaatg tcatgccgat gtaccaggaa ggagagatat cggtcgatct gatgcgctat 843241 cgcggcgacg ctccaaatgg cattatggac gcattgttta tccgtatgtt tttatgggca 843301 aaggaagagg gctgtacgtc atttaatatg gggatggcac ccttggccaa tgtcggcact 843361 gcctttacat ccttctggtc cgaaaggttt gccgctgtca tttttaataa tgtcagatac 843421 atgtacagtt tcagcggcct aagagccttt aaagaaaaat ataaaccgga gtggcgaggg 843481 aaatacttag cgtatcggaa aaacagatct ctttctgtca ccatgttcct cgttacacgt 843541 ctgattggca aaagcaaaaa agactccgtc taataagacg gagtcttttt ttatttcgtt 843601 tttaagaagt aggtttcaat atcatcaagc aggtagtttg cggctttaat tccgcctgcg 843661 gttgtccata cgacgtcatc gacttcatgt gcattacctg acttcacggc cttcaggttt 843721 ttccatagtg aactgcttgt ccactgattg gcccattttt cattttcttt tgcattatcg 843781 gctttataag tgaaataaaa cagcacatca gcatccatat caggaataga ttctttactg 843841 tcggttgaga acgtaaattg gtccttttgt ttcttaaaca gttccacttg tttttcaggg 843901 cgtttgaagc caagctggtc taaaataatc ccaggaaatg aatcggtata atagattctt 843961 gattcaccgg ataaaaagcg tacgactgaa acggttttgt ttgtctggtc gcccagcttg 844021 ttttttaaat cagaaacacg tttatcaaaa tcggcaatga cttccttgcc tttgtccgcc 844081 ttattcaccg cgttggcgta tagagtcagg ttatccttcc agttcccggc caaagattca 844141 gcaaaaacag tcggcgcaat cgcatttaac tgatcataaa ttttttcctg gcgcactttg 844201 tttccaataa tcaaatcagg ctttaattct gcgatggctt ccacattcgg ttccgtttca 844261 agaccgacgt ttttaacacc tttcatgtca tctttcagat agtcatacca cgggtcgccc 844321 ttccatgact ttacggctcc gaccggctta atgccaagcg ctaagagcgc ctctgttcct 844381 tcattagtta aaacaacaat ccgttttgga ttggcgggga tgttgtctga tgtccccatt 844441 gcatgtttga ccgttcttgt tttgctgctt gacacctcgc tgttgcttga actttctgaa 844501 ctattacagg cagaaagtac cataacggcc attaaaaata cgaatagcat gctgatatgc 844561 tttttcatct ttttcctccc aatattgaaa ttcattatca tttagatcat aataagcagt 844621 gttaagagtg tcaatcccta attgaggatt attctcaaaa acaaacatta catagtaaat 844681 aactaggaga attagatcat gatctgcaaa aaggcatctt caaaatggat tgtgttagta 844741 tgtctgattt tcattttact gacggctgtc tgcgcaagcg tcgtgtatgg ctatacaggt 844801 acgtcatgga gacaggtcta tcaggcgttt acttccttca atggaacaaa tgagcatgtc 844861 atcatcaagg atgtcaggct tccgcgcgct ttggttgcga cagtcgtcgg cgcctcgctt 844921 gcagccgcgg gcgctctcat gcaggcgctc acaaaaaatc cgcttgcgtc accggggatt 844981 ttcgggatta acgccggtgc aggttttttt attgttgccg gatcgttttt tctgcatatt 845041 cagtcacctc aggcattagt atggagctcg tttctggggg cagcatttac cgctgcgatc 845101 gtctatgcag caggctcgct tgggagggaa gggctgacgc caatcaaact gacgctggcg 845161 ggagctgcca tggcagccat gttttcttct ctgacacagg gcttgctgtc tgtcaacgaa 845221 ctcgagcttg cccaggtgct tttttggctg actggctctg tgcagggccg gagtctggat 845281 ctgttgatga cgatgtttcc atatgcagcg gcagcgctgg taatctgctt ctttctcggc 845341 caaaaaatta atctcctcgt tatgggagaa gatgtggcaa aaggactcgg ccaaaaaaca 845401 ggcctgctga aatttgtgat ggcgctttgt gttgtcatgc ttgcagggtc cgctgtcgcc 845461 attgccgggc cgatttcttt tatcggcatc attattccgc attttgcccg ctttgtcgtt 845521 ggtaatgatt atcgctgggt tctgccattt tccgctgttt tgggtgccat tttgcttgtt 845581 tgcgcggata tcggtgcgcg atatatcatt atgcctcagg aagttcctgt cggggtcatg 845641 accgccatca tcggaatgcc tgtgtttgtg tacatcgcaa gaaggggggc gaagctatga 845701 aacttcgttt tggcgttact gcggctgaaa agaaagcatg gatcgtcttt ttggttttac 845761 tggggttaac agctgctgta ctcatcataa gcgctggtct cggacaaagg tttattcctc 845821 cctgggatgt agcaaaaaca ttctttggtg caggttccaa gctggatgaa ctgatgatca 845881 tgtcgttccg catgccaaga attttgacgg ctttatgcgc cggtgtctgc ttggcagcgg 845941 caggcgcgat attgcagggg ctcgtcagaa accctctcgc atctccggat attatcggaa 846001 taacaggagg agcggcggta gcggtcgtgc ttttaatgat gttcttctca gaccgcagca 846061 gttcacttac gatcagtctg tcatggcttc cagcagccgc atttatcggc gcatcggctg 846121 tcgggctcat cgtctattta ctggcataca aaaatggcgc ctccacattt cggctggtgc 846181 ttatcggaat cggattttca atgtcggcgc aggcgatgac taccctgttg atgatcaaag 846241 gcccgattta ccgagcatca caagccaatg tgtatatcac tgggtcagtt tatgggtcaa 846301 actggcagca tgtaaaaata gctattatct tatctgtcat tctcttattc atttgttttg 846361 tcgcgctaaa aaatatgaat atacaggtgc tgggtgaaga tattgcggcg ggtgcaggaa 846421 gcgctgtgca gcgaaatcgt tttttcttgc tccttttgag tacggctctt actggttgtg 846481 cagtttcagt tgccggcaca atcggttttg tcgggctgat ggcgccccat attgcaagac 846541 ggcttgtcgg ctcatcttat ggcgcgctgc tcccagcgtc ggcacttatt ggagctctgc 846601 tcgttttaac agctgatatc gtcggcagaa ccttatttgc tccggtggaa gtgccggccg 846661 gcgtctttac agcggctatc ggcgcacctt attttattta tttgctctat aaaacaagaa 846721 attcttaatc gttacaccca ttttcttaaa aaagaaaatg ggtttttttg ataatgactg 846781 aagattcgta attatttttg ctatactgac agagacattg ataaagaaag ggcggcagat 846841 gaatgaaaga agcagaggta ttaaaatatg aagcatttac aagcagtccc ggcaaaggaa 846901 accccgcagg cgtcgttttg cagggagacg attatacgga agacgagatg cagatcatag 846961 ctgaacgtgc cgggtattca gaaacctcct ttatccgaaa aagcgagtcg gccgatcttg 847021 aactccgtta ctttacccct ggacacgaaa tgaatttgtg cggtcatgcg acagttgctt 847081 ctctttacgc attatgtgag aaaggaatgc tggagagcgg taaaacgtac agcatccaaa 847141 cgaaagcggg tatcctgcct gtgaagattt ctgaaaaaga tggccgcatt catatcacgc 847201 ttgaacaggc ctctccgcaa ttcaaaccat ttacaggcga tcggaaaaaa cttgcggacg 847261 cactgggtat caccgatgaa gattttcatg aagaccttcc gattgtgttt ggcagcactg 847321 ggatatggac agccatcgtt ccgcttaaat cattggaggc ttccaaaaaa atggtgccag 847381 ataacaaaca atttccggaa gtgttagttg atctgccaaa agcttcagtc catccgttta 847441 cctttgaaac cgtccatccc gacagcgacc tgcacgggcg ccacttttca tccccgtatt 847501 cgggaacgat tgaagacccc gtgaccggca cagcatccgg cgtgatgggg gcttatatga 847561 aacattatgg caatgccgag cagcataaat ttatcattga acaagggcag gaaattggaa 847621 aagacggaaa agtggagatc gaaatgaacg aagccggcgg ccatgtgaaa gtgaacatga 847681 caggaacagc cgtttactca gaaacccgta ttcttaaaat ctaatacgga tgatggttta 847741 caaaaagatg cactttccgt tatcattatg aaatgataat cattttcaat tgcataggaa 847801 ggtgagacgg tatgcctcaa accgaacaaa tacatcagca ttcagtactg agggacatca 847861 tacgcagcag aagatcgatt cgaaagttta aacaagagcc agtaccttca gcagtcattc 847921 ttgacatgct tgaaacggca aaatatgcgc caaatcacag agtgacagag ccatggagat 847981 ttatttacgt ttccagtgag acaggtaaag cgaacctcat taatacattt gcagcgttct 848041 ctaagaaatc caagccggat atgacagagg aaaagcttca aaatttcaaa aacacacttg 848101 ggcgcgttcc gggatttctc ctcgtcgtgt ttcaggaaga tgaaaacgaa agagcgcggg 848161 acgacgattt tgcggcaaca agctcgttga ttcaaaatct tcagcttctc gcttgggaaa 848221 aaggaatcgg catggtttgg aaaagcggaa aaatccttta tgacaaagaa gtccatcagg 848281 cctttggttt acaggataat gagcgtttcg ccgccatcat acaaacaggt tatcctgacg 848341 aggcgccgga agtgaaaaaa cgcacaccga tccgcgaccg attcactgaa atgtaaaaaa 848401 ccccttgtct caaacggaga caaggggttt ttcattaacg agatttcttt ttcgctctgt 848461 tgtcggctgc tttcgcacgc tcttgcgctt cgcggtcatc tgcatcagca agctcggttg 848521 aatattcttc gtaaacgccg tcagtttccc tttttaaggc atcgggaact tgtggaagct 848581 tttgtttgtt tttatcacgg tttttgtgga tatgatttct gcccatatca aattccccct 848641 aaaaagtgat atcaaacaaa tatagtattt ggttttaagg ggctatgtat tcctacttcc 848701 gcttagcagc tttttccgct tttttaaatt cgcctgaata aagaacttcc tgcatttttt 848761 tcaggttggc gccttgctgg tgcttctccc tctttttttc cataaaaagg acctccttca 848821 accatgttat tcttaaggtt gacgcttcct gctgttttta tacagtcttt cggtccgcta 848881 tcagctgtga gagtgcaaat tcaagatccg aatatgtaaa acgaaatcca gaggttatcg 848941 cttttttcgg aagagcgcgc tgtcctttca caatcaaaag actcatttca cccaatgctt 849001 ttgataaaaa gaattccggg acggggagcc agtgcgggcg gtgcttcacc cgtgcaatcg 849061 tttttccgaa ttgcttcatg tccacaggat tgggcgcggt gacattcatt gggcctgaga 849121 tgccggcgtt ttccaccgca tatcggatca tctgggccgc atcctcgaca tgaatccatg 849181 acagccactg ccttcccgtt ccgatcgttc cgccggccag aaacttatag gggagaatca 849241 tgagcgggag agcgcctttt tctccaagca tcacgccaaa tctcgcataa actgtccgga 849301 tgcccatcgc ttcaatatgc tgtccttcct tttcccacag gtgtgcagta tggctgagaa 849361 aatcctcatc tgacgttgca gaatcctctg tgaaagtttt ctcaaggctt gtgccgtaaa 849421 tgcccacggc actggcttgg atcaatgtct tcggcttctc cttctgtttc tgaataagcc 849481 gctgcacttc acgcgtcgca ttgatacggc tggagagaat gtgctgcttc gttttttctg 849541 tccagcggcc aaaaatcgat tttcccgcaa gatttatcca gacatcaata tgaggaagtt 849601 cctgctccgg tgcggctcct tccgacagcc attggacata tgtcatattt ttttgttcag 849661 tttcccttgc gtttcttgat aaaatataaa catggtgtcc ctggcgggta agaacgcctg 849721 tcagatgctg gccgagaaaa ccggttccgc ccgtcattgc gatattcatg aacatctctc 849781 ctcatcgttc taataaatat actttacctc attgtaataa aagaaaacgc gtttcaggcc 849841 tgagaaggga gattaagatg ccgtttatta caaaaatatc aacgcaaaaa aagaatacgg 849901 aacgcttcaa tatttttctg gatgataaat acgccttcag cgtggacgcg gatgtgctcg 849961 tgaaatttga gctcaagaag ggaaaagaac tcgatgatct tgacatcatt gagattcaat 850021 acggcgatga agtgaagaaa ggcttcaacc gtgcgcttga ctttttatcc tatcgaatgc 850081 ggtcgacgaa agaggtcgag gatcacttaa agaaaaaaga aacctcgccc cccgtcattg 850141 cggaagtcat ccataggctt aacgattaca agtacttaaa cgaccaggaa tttgccgcag 850201 cctatgtcag cactcacaaa aaaacaaacg gaaaaggccc tgatgttttg ttcagagagc 850261 taagagcgaa gggaattgat gacgatacaa ttaaggaggc gctaagttcc ttttcctttg 850321 aagatcagac aagagaagcg gtcaagcatg ttgaaaagct tctcaaaaaa gataaaaagc 850381 tttcgacgaa agaactcaaa cagcgcgccc agctgcagct tcagcgcaag ggcttctcat 850441 ttgatgttat cagcgcggcg atggatcaga ttgaatatga aaatgatgaa gacacagaga 850501 aagaagcgct gcgccttcac gcggaaaaag cgtttagaaa ataccgctat gacggctcat 850561 atgaaagcgc catgaaggtc aaacaatttt tattccgcaa aggattctca ctcgatttaa 850621 tcgagcaatt actgcaggaa gaggagtact gaaatggaga aacgatacag tcaaatgaca 850681 ccgcatgaac tcaataccga aatcgcatta ctttctgaaa aagcaagaaa agccgaacag 850741 catggaatca taaacgaact ggcagtgctc gaacggaaaa ttacgatggc aaaagcatat 850801 ttgctgaacc cggaagatta ctcaccggga gaaacatatc gtgtggaaaa cactgaggac 850861 gagtttacca tcagttattt aaatggcgtt ttcgcatggg gatacaggac ctcttcccct 850921 cagcaagagg aagcgctgcc aatctcagta ttgcaagaaa aagaataaag cgtaacagga 850981 ggctgatgat cagcctcttt ttgtttgcag cacatttaca cgaattctta aagaaaaaat 851041 cattgaattc acttgaaaaa tcttttaaga tgaaactcgt tgttttttaa aatcaaagga 851101 ggcgatgacg ttgagtatca aaaacccatc tgtaaaattt attatatttg ttcttatgat 851161 ttgtacattt tcaatcggct atacagaata cgcggtgatg ggtattttga cgtcgattgc 851221 caatgacttt catatacagg tttcatccgc agggcttctt gtcacggctt atgcggcaag 851281 cgtttgtttg acagggccgc tcgtcaccat catttccgtc aagcttccga gaaagcctgt 851341 gcttcttggg ctgatggcga tatttatcct ttccaacctg atgagcgcac tggcgccgaa 851401 ttttgcggta ttggccattt caagaatttt atctgcgtcc attcacggcg ctttcttcgc 851461 gattgccatg gtattcgcaa gtgaaatggt tccgccggaa aagcgtgctg cagctgctgc 851521 ttcaatgaac ggcggactga cagtggctct aatgcttggt gttccattcg gctcttatct 851581 cggagatgtc ctgaattgga gagcggtgtt ttccatcatt acggcacttg gtgtcatcgg 851641 atttttaggc cttatggctg ccgtgccgaa cagaaaacca aaagtgatcc caatgcttat 851701 gaatgagtgg ggtgttttta aacacaaaca agtgctgttt tccttcgcga ttaccatttt 851761 aggctattcc ggtgtcttta tcgcctacac ctttatcgaa cccattttga ggcattcagc 851821 cggattcagc acggttggca ttacaggtgc tctctttgcg tatggattgg gaggcgttgc 851881 cgggaatttc tttgctggaa aggtaccgct gcctttgctg actcggacga tgatcggcgt 851941 aatgatcggt ttaatcggtg ttctggctgt atttccttac atcgccattt acccggctgc 852001 agccattgtg gcaacgttcc tattcggggc atgcgcattc ggcacgccgc ctcttctgca 852061 aacaaaggtc atttcctcat ctgagggcgg cacaaccatt gccgcagctg tcagcgtatc 852121 agcatttaac cttgccaatg cccttggtgc atggatcggc ggaatgattt taaacggaac 852181 aggctcttat tcctggctgt ttgcaggagg tgcgcttatg accgcatgcg gacttgtgct 852241 ttctaccttc gcacacttat cagaaaagaa gagcgtctac gaatatcaag tcaataaagg 852301 gtaaaaaaca gctgcagtgt atgcagctgt tcttctttac cgtttgcctg aggctctcat 852361 tctttcttga ggatgctgat tgatagatcc gtcagcacgc tttgaagcat agtcgtcctt 852421 tgctctcggt tcaccctgaa atttgttttc gttttcgtaa ggaaatcctt tttctttatt 852481 tcggaccatg tcatatcccc ctaggttcga gatcaaaaag ttgcgtcttt tcagatgaag 852541 acgtaaggtt agtatatgga gaacaccacg taataaagcg ttattttttt cctgaagaaa 852601 ggagactgca cacatgaata tgtacattga gaaactgact aatctgcttc tggaaaagaa 852661 cgagatgatc agctatatac aggcaaaaac gtgggtggaa ttgttatgga gcgatttcga 852721 agcaacctac gcaaaagccg gacacgccta tcaaggtgaa aaaatgactg aaaaaatcgt 852781 cacacaatgg attgaaaact atggcggcca gctccacctt tttcaaagct cccgtaacga 852841 cgtgaatgat tacttaaatc aaagcagagg ccttttgcat taaaaacctg ccgttaacga 852901 ccggcaggtt ttttcatttt cttaaaatta ccttaacagg aagaaatcat aaacaaaaca 852961 tgtttcacca gcctgtcaat cagggaatac cacttatatc ttgtcaaaat gcgaggagga 853021 gctttatatg aaaaagaaac aagtaatgct cgctttaaca gctgccgcag gactgggttt 853081 gacagcactt cattccgctc ccgcagcaaa agctgcgccc cttcacgaca tatctgtcag 853141 catgccatca tccgatactt acatcataaa agcaggaaag ctgaatgtcc ggactgagcc 853201 aaatcatgaa ggtgatattc tcggcactgt atcatcagaa caaaaggtaa aagtcgatag 853261 gttcgtaaat gccgattggg ctcaaattca tttcaaagga aagaaagcat atatttcaac 853321 tcacttttta atgaaaaccg caagccaagc gaaaacaacg aaacagacag ccttctatac 853381 accgacgccc gaaaacggaa aagctaagca gctctcatct ggaacagagg tgacaatact 853441 tgggtgggga ttcagtgaaa acggcggatt tgacttcact tgggcgttcg tggattatgg 853501 cggagttaaa ggctatattc acacaaagga tttacaaatg cgataaaaag gcaggccgag 853561 gcttgtcttt ttgcctatgc atgaaacatt tcttctttct gcacgtaaca atgagaaagg 853621 agatgatgat atgacgggtt tagtcggcgg agggcttatg atcattgcgg gcatactgat 853681 caaactgttt cctcccaaat cgatcaacag tgtgtacgga tacagaacga gacgctcaat 853741 gtcagatcaa agattatgga atgaagcgaa ccgttacagt gcatcattaa tgatcctgtc 853801 aggcttggtg attgcgggaa tgggtttgct gctgggatca aacttgttta ttcttcagct 853861 tatcctgctg attgccgcct gtgtcataac atttatgcta acggagaaaa ggctgaaaat 853921 catgacgcac agtcaaggag gagatagaag tggacggagt taaatgccag tttgtcaata 853981 cgaacggaat cacgcttcac gttgcagccg caggacggga agatggcccg ttaattgtcc 854041 tgctccatgg atttcctgag ttttggtacg gctggaaaaa tcaaatcaaa ccgcttgttg 854101 atgcgggtta ccgggtcatt gctcctgatc agcggggcta caatctcagt gacaaaccgg 854161 aaggaattga ttcgtatcgg attgatacat taagagatga tatcatcggg cttattacgc 854221 aattcactga tgaaaaagca attgtcatcg gtcatgactg gggaggagct gtcgcatggc 854281 atttggcttc cacacgcccg gaatatcttg aaaaactgat cgcgatcaat atcccgcacc 854341 cgcacgtcat gaaaaccgta acgccgcttt atccgccgca atggctgaaa agctcgtata 854401 tcgcatactt ccagctgccc gatataccgg aggcatcact aagggaaaat gattatgata 854461 cattagacaa agcgattgga ttatccgacc gtcccgcgct ttttacatcc gaggatgtca 854521 gcaggtacaa agaagcgtgg aagcagccgg gcgcgctgac agctatgctg aactggtaca 854581 gagccctcag aaaaggaagc ttggcagaga aaccctctta cgaaacagta ccttaccgaa 854641 tgatctgggg aatggaagac cgctttttga gcagaaagct tgcgaaagag acggaaaggc 854701 attgcccgaa tggacatctc atctttgttg atgaagcttc ccattggatt aaccacgaaa 854761 agccagccat cgtcaatcag ctgattttgg aatatcttaa gaaccaataa gctaaaattt 854821 ctctccatcc gtctgtcata atggcagact ttttctgtgc gttttttttc atagtctgtt 854881 ttaaacatga caaaataaca ttaaaaatca tgaatgtcac cataaaattg taacaaaaaa 854941 caggtttaaa cgactttaaa aaaaggaata gccttactga agatttgtgt aaaactcccc 855001 taaggcaata cttaaaaaga ataataaaaa gaaggtgcct taatgaagca aggattaatc 855061 tcgattatta tcccgtctta caatgaaggg tataatgtta aactcattca tgaatcttta 855121 aaaaaggaat ttaaaaacat tcattatgac tatgaaatat tcttcataaa cgacggaagt 855181 gttgatgaca cgcttcagca gatcaaagac ttggcagcga cgtgcagccg ggtaaaatat 855241 atatcttttt ctcgaaactt tggaaaagaa gccgcaattt tggcgggctt tgagcatgtt 855301 cagggcgagg cggttattgt catggatgcc gatctgcagc atccgacata tttgctgaag 855361 gaatttatca aaggctacga agaagggtat gaccaagtca ttgcccaaag gaacagaaaa 855421 ggggacagct ttgtccgctc actcttatca tctatgtatt acaagttcat taataaagcg 855481 gtggaagtcg atttgcgtga cggtgtcggt gacttcagat tgttaagccg ccaagctgtg 855541 aatgcacttt tgaagctgag cgaaggaaac cgcttctcaa aaggcctttt ttgctggatt 855601 ggctttgatc agaaaattgt attttatgaa aatgtcgaac gaaaaaacgg cacctccaaa 855661 tggtcgttca gcagtctgtt taactacgga atggacggcg tcgtttcatt taatcataag 855721 ccgctgagat tatgttttta tacaggcatt ttcatcctgc tgctttccat catttatatc 855781 attgccacat tcgttaaaat tctgactaac ggtatttctg tgcctgggta tttcaccatt 855841 atctcagcag tgttatttct cggcggagta cagctgttaa gtcttggaat aataggtgaa 855901 tatatcggcc gaatctatta tgaaacaaaa aaacgcccgc attatttgat caaagaggcg 855961 aatatcccga acaaagacct gcctgaaacg aacgaattaa aaagcatgcg gcgtctgaca 856021 aaaatgcact gaaaatacca agcgccattg gcagtgcttt ttttgcgtgt ctattatctt 856081 aaaagcaaga ctggagaatt catatgaaaa gaaaacatat catgatctat gcggccagtt 856141 tgctggtgtc cgttctggca cacgcttttt ttgtgaaaga atgggcggaa ggcaggtata 856201 tgacaggtcc gggtgacggg cttgcgcaaa tgatcgtatt taaaaaatta ttatttgacc 856261 aatatacaca cgggaatttt ttctacaatt attcattcgg acttggcggc ggcacattca 856321 gtcagctcgg ctattatttt tctgcgtctt ttctttttct tgctgtgtct gccgctgttt 856381 ggctgcttca agccgtccag ctgatcggag aaacggatac gcttttttgg gcagagtcag 856441 ctgtttttat cagtattttc aaattgagct tgatcatctt tacgtccgct tctgtttttc 856501 attatcttct taagcacagg gcggcatcgt tcacgggagc cgtgttatac ggcgtctcaa 856561 ttatttattt ccgtcacgaa gcgtattggg aatttttcac cgatacaatg gtttggcttc 856621 cgctgcttgt gcttggcgca gaaaaaatta ttagagagcg gcgtccggcg tggtttatcg 856681 ttgcgtgttc gctgacgtta atcaacaatt tttactttgc atacataaac cttatattca 856741 tcggaatcta tgtgctgttc agatggctga tccgtttgga accacatgaa gagaaaagat 856801 ggattcaaat cagattattt ctcgtttcag gcttcatttc ttttggcatc agtgcggcgg 856861 cgtttgtgcc ggtagtatac ggttttttaa acaacctgcg ccctccatac agccagaaaa 856921 tagagtggct caatttcgat gataatatct tattttcgag ccggatcatc attgtgccgg 856981 ccgcttttct gctgtttttg tttattattt ctttttacaa aaaccgtgtg tttcgtctct 857041 ttgccgggtt gagcctgctg tttattctgt ttcatttcag tccgtatgcg gcaagcgtct 857101 ttaacggttt ttccgccccg caaaaccggt ttgaatatgt tctggccttt accattgcgg 857161 gagcagctgc ggctggtttg tcacagctgt ctgaattgaa acggaaagaa ctgctcccgg 857221 ccgcagctgt cgtcctgctt ctttacttgt atcatatcca aaggtataag ctcgatatat 857281 ggaagcctgc gaatgaaagt attctattgc tcttactcat gacaatcgca gccttgtttg 857341 ctgcagcttt tgcgaaaaaa cgggcaaaaa tggctgtgta cggtataatc attctttctt 857401 cgctgtttgt cgccaactcc tatcaaaaat acgcgctctc agaaggcggc gatttggaca 857461 gtgtgacaaa agaatatctt acaagtgagg aatacagagg gcgggaatca tctgagctca 857521 tcagacgttt acagaaggaa gacgatgacc cgctcatgag aatcgactgg atgaacgggg 857581 tccgcaataa tacgccaatc atttacggat ttaatggctt cagcgcgtat tccagcattt 857641 taaacaaaga tctgctggcc ttctattgga atgatttaag catcgatatg ggcagggaaa 857701 gcgtcagccg ttacgcgtca ttgggagaca gggcgaattt atacagcctg ctttacggca 857761 aatattatat gaccgaaaaa acaaacgaag ccagcgtccc gtacggcttc aaaaagcatt 857821 tagaaacaga gcattatgca gtttatgaga atcagtacat gcttccattc gttaaaacag 857881 cggatgccat atacagcgaa agtgagctgg accgattgcc cgctcttgcg aaagaacagg 857941 cgatgctgaa aggaattata ttaaaagatc catcaggaaa aacggagcag acaccaaaac 858001 cgtccaattt gatcaccaag tcggacatca ccgcaaaaca agcccagtat caaaacgggc 858061 tgctaaccgt aactggagaa aacggaggag agctgatcat caccccgaaa cagccatcat 858121 ccgctccggg agactactat gtcagctttt atttgaaaag caaagcaaaa gacaaaggat 858181 ttacattaaa ggtaaatgat tatgtcacaa caaggaaatc gaacaaatcg atctataaaa 858241 ccggagtaaa taatataacg gtaagagtgc ctaaatcagg ccatatctca atcaatcttc 858301 cgaaaggaac ctatgagctg agaaacatag cgctctatga agaaaattac caaacgctga 858361 aaaacgctgt aatgcaaaat aaaacagaga aagcagacaa actgaattgg aacaaaaatc 858421 gactgacctt ttcctatcat ctgtcaaaag accagtacat catgcttccg atcccatatg 858481 aaaaaggctg ggagctgaag atcaacggaa aaacacagaa gatcgaaaaa gcggattatg 858541 cttttatagg cttcaaggcg caaaagggag acaatcacat tgagctgact tactatccgc 858601 catacttcaa aatatcggcg atcatatctc tcgtcagtct gctgcttgct gttttttata 858661 taagacgtaa aaagcccggc tctatataga gccgagcttt aattttttct gaagtttttc 858721 ttcgctgaat atccatcccg tataggatga acgaatcgtg agatcatggc cgatatgaac 858781 aattgcgaca aacggataat ggcctttgct ccgataacgc aggtcgataa atctcacctc 858841 ataatgatct ttaaacgtat ccacttccca ccggtatacc ggagaaaagg acagaaacgc 858901 cgcgatgtta tcatcctgct ttgccgcatg cattacatcg gtttcaggaa caggcacccg 858961 attaaatgta tccagaatca cgacatgtcc ttccatgctt cttcctacat agaaagcatg 859021 tgctgtcgtc actgcgattc gccattgcct gaatttcatc gttggagaaa taataatgct 859081 ttcgatctca tcatgaatca tctcatgaag cttccgttta attctcagct gcatgatcag 859141 gcgcaccaag tagtagccta ccaatatgat atataagctg agaaacgtga tgccgggact 859201 cccgcctgca taccaaatcg cgatagctgc cagatggctg ataaaaataa acggatcaaa 859261 cgtattaatc agcccgagcg caacccattt tttcgaaaac ggacgaatgg cttgtgttcc 859321 ataggcgttg aatatatcaa caaagacatg cagaacgact gccagcagtg tccacagcca 859381 caggtgcaga aaatcggcct gaggataaaa taaatacaga atcgccggga tgatgacaga 859441 ccaaaacaaa acggcgggaa ttgaatgggt aaatcctctg tgattcctta tataaacagc 859501 attgttttta agctttaaca cagtatcaat atccggagcc tgagagcccg caagcgttgc 859561 gatcataaca gcgtgagcca ttgccggatc tgatccgaca acaggatcaa gcgtcgcaat 859621 accgcccagt gcgatgccca taacgacatg tgtgcccgta tccataggtg acctccttgc 859681 agggtgatcc tgcacattca ctttgtaaga aattccccat tttcatatac ccaattttta 859741 aactgattca atcgttctca tatgtttccg ctttttcttt attactattt aatgtaacat 859801 attatcgtac tgtgccctta gtgtacaaca aaaaacagtc taaagaaaag cggggcgcga 859861 aagactgggg agaaacacat atgaacgtac ttgaagacaa attaaaacaa aaagacatac 859921 agcaatttcg cgatgattta atctcatggt ttgaacgaga gcagcgcgtt ttgccgtgga 859981 gagaggacca agatccatat aaggtgtggg tatctgaagt gatgctgcag caaacgagag 860041 tagagacagt gattccttac tttctccggt ttgtagaaca attcccgaca gtggaagcgc 860101 tcgctgatgc tgatgaagaa aaggtgctga aagcatggga agggctcggc tattattcgc 860161 gagtcagaaa cctgcaaagc gcggtaaaag aagtgaaaca ggaatacggc ggcattgttc 860221 ctccagacga gaaagatttt ggcgggttaa aaggcgtcgg cccttataca aagggagcgg 860281 tgctcagcat tgcctacaat aaacccattc ccgcggttga cggaaatgtg atgcgtgtca 860341 tgtccaggat tctatctatt tgggatgata ttgccaaacc aaaaacaaga acgatctttg 860401 aagacgccat acgagctttt atttccaaag aaaaaccatc tgaatttaat cagggcttga 860461 tggagcttgg agccttgatc tgtacgccaa aatcaccctc atgcctgctt tgcccggttc 860521 agcagcattg ctcagcattt gaagaaggca ctgaacggga gcttccggta aaaagcaaaa 860581 agaaaaagcc cgggatcaaa accatggccg cgatcgtact gactgatgaa gacggacaag 860641 tgtatatcca caaacggccg tctaaaggtt tgctcgccaa cctgtgggaa ttcccgaatc 860701 ttgaaacaca aaaagggatc aaaactgagc gtgaacagct cattgctttc ttagaaaacg 860761 aatatggcat acaagctgat atcagtgatc tgcaaggtgt agtcgagcat gttttcaccc 860821 acctggtatg gaatatttca gtgtttttcg gtaaagtaaa acaagtgtcg gataccagca 860881 agctgaaaaa agtaacgaaa gaagagctcg aacaatttgc gttcccggtg tcacatcaaa 860941 aaatctggaa gatggcagga gaagcagccg ccatctcggc tgctccgtaa accattctta 861001 atcgtaagag acgcgcgtgc cgtggctgta gtccgcttca ttgcgcttca ttccgccgcg 861061 cgcttcaatt tcttgcgtta attcccggta ttttgattgg ccttcttcgt tcaaataagg 861121 cataatttgc tgaaaggcat gatgaaaata agcgagttca ctgttcttcc aatctttttt 861181 ggaaaccatg ttcaattcgc tcatatcacg tccgacatac ataacagaag acccccttta 861241 aagttcttgc cattattgtt tgtggaaata aaagaactat acgctacaag gagatgagga 861301 aaaatggaac aaaataaatg tgcactcgta acaggaagca gccgcggtgt cggaaaagcg 861361 gccgcgatca gacttgctga gaacggctat aacatcgtca ttaactatgc acgcagcaaa 861421 aaagcagcat tagaaacagc ggaagaaatc gaaaagcttg gcgttaaagt gcttgtcgta 861481 aaagcaaacg taggacagcc tgcaaaaatc aaagaaatgt ttcagcaaat tgatgaaacg 861541 ttcggcagac ttgatgtttt tgtcaataat gccgcttcag gagtactaag acctgtcatg 861601 gaattagaag aaacacactg ggactggacg atgaacatta atgcgaaagc attgcttttc 861661 tgcgctcagg aagctgccaa gctaatggag aagaacggtg gcgggcatat tgtcagcatt 861721 agttcattag gctctatccg ctatcttgaa aactacacca cggtcggtgt atcaaaagca 861781 gcgttagagg ctttaacccg ttatcttgcc gttgagcttt caccaaaaca aattatcgtc 861841 aatgctgttt caggcggagc gatcgacaca gatgcgctga agcacttccc gaatagagaa 861901 gatctgcttg aggatgcgcg ccaaaatacg ccggcgggac gcatggtcga aattaaagac 861961 atggttgata ctgtggagtt tctagtgtct tccaaggctg acatgatccg cggacagaca 862021 attatcgttg acggcggacg ctcactgctc gtttaaaaat ttttaaaaaa gaggaatagc 862081 tatacgatca cctgcacatt ctaatgaccg tggaggtgat aacaatggct aactcaaata 862141 acttcagcaa aacaaacgct caacaagtta gaaaacaaaa ccaacaatca gctgctggtc 862201 aaggtcaatt tggcactgaa tttgctagcg aaacaaacgc tcagcaagtc agaaaacaaa 862261 accagcaatc agctggacaa caaggtcaat tcggcactga attcgctagt gaaactgacg 862321 cacagcaggt aagacagcaa aaccaatctg ctgaacaaaa caaacaacaa aacagctaat 862381 cactgaaaca gaaaaaagca cttcatcttc gggtggaagt gcttttttct gtttgaaaaa 862441 cgacaaaact tgtggaaggt ctacagaatg agtcaaaggg tttgctttat ggagatcgaa 862501 atgattaaag gaggaaatgt ttatactttc atcaggctga aggaggaacc gatgaccgaa 862561 tttgaaaagc tggtaagtga acagatgaaa acgatggata agcttctcga tctccaatca 862621 gagctcgacc gctgcaaaca aattgaggcg gaactccggc atttggaaag ggatgcaagg 862681 ctgcgtggga ttcaggctga aattgcggta aaacggaaac accttgccga tatacaggat 862741 atgtttcaaa agcagacaga gcaggtcatt cgttcatatc gcagctcaga aaagccgtct 862801 tcctttgtgt agtgcaggaa tgtgccattc cccggccgga atggctcttt tattttcatt 862861 tttcaatttg taacgttata ataggtaaaa gacgttgtcg gtaagcaaat ttggacatac 862921 taactgtagg gctttataga aagtagggga gaaatatggg ctatcccaag gaaggagaaa 862981 ccattcaaat tcacagctat aagcacaacg ggctgattca tagaatttgg aatgagacaa 863041 caatcttaaa aagtacagaa atgtgtgtca tcggagccaa tgaccggacg atggtaaccg 863101 aatcagacgg ccggacatgg ataaccagag agcccgcaat ctgttatttt cacgcaagac 863161 aatggtttaa tgtcatcggg atgctgaggg aagacggggt tcattattat tgcaacatca 863221 gttctccgtt tgcctatgat ggcgaagcaa ttaaatatat tgattatgac ttagatgtta 863281 aggtttttcc tgacatgacc tacaatattc tcgatgaaga cgaatatgat gatcatcgga 863341 aagccatgaa ttatccaaaa gaaatcgaca gtattttaag agactactta aatacgctgc 863401 tccattggat tcaccagcgt cagggaccgt ttgcgcccga gtttgtcgat atgtggtatg 863461 aacggtattt gcgctataca aaataatggt tacgtaaaaa cctgttgcgg ggtacaacag 863521 gtttttcaca tgggctcaca cacatcatga taaagagaga gggggaatca accgtggggg 863581 ttatgaaacg ctacatgcaa ttcgtcaaac cttataagaa gcaaattttc gttacagtgt 863641 taatcgggat cgtaaaattc tccattccgc ttgctctccc attgcttctg aagtacgtag 863701 ttgacgacat tattcaagga ggcggcacgg ccagtgacaa aaccacgtca ttgttcacga 863761 ttatggcgat catgttcgcc ttatttttaa ttttgcgccc gcctgttgaa tattaccggc 863821 aatattttgc ccagtggact gccagcaagg tgctttatga tataagagct aagctgtttg 863881 accatataca aaaactgagc cttcgttttt acgcgaatac aagaacaggg gaagtcattt 863941 cccgagtgat taatgatgta gaacaaacaa aggatttcgt catcacaggg ctgatgaata 864001 tatggctcga tatgctgacg attttgattg taatctctat catgctcaca ctggacgtta 864061 aattaacgct gatctctatc gttttattcc cattatacgg aatatcagtg aagtattttt 864121 acggccgttt acgaaagctg acaagggagc gctcacaggc tcttgctcaa gtgcaggggc 864181 atttgcatga acgcattcaa ggcatgcctg tcatcagaag ctttgcgata gaagatcatg 864241 aacaggctca atttaatgag aaaaacggtc atttcttaga taaagccatc cgccacacga 864301 attggaacgc gaaaaccttt gcggtcgtta ataccattac agatttggcg ccgctcatcg 864361 tcatagcgtg cgccgggtat tttgtcatta atggaccgct gacagtcgga acaatggtcg 864421 cgtttgtcgg atatattgac agaatgtaca accctgttag aaggctgatc aattcctcta 864481 caactttgac acagtcaatc gcatcaatgg acagggtgtt tgaatttatt gacgagccct 864541 atgaactcac tgacaaacca aatgcgataa aggccgatca gattcgcgga ggagtggagt 864601 ttcaaaacgt ttcgtttcaa tatgagaagg acaaagaaaa tattcttcat gatgtatcct 864661 taaaagtaaa tagaggagaa actgtagctc tcgtcggcat gagcggagga ggaaaatcaa 864721 cgctcgtcag cctgatccca agattttatg atgtaacaag cggcagactg ctgattgatg 864781 ggacggatat tcgcgattat gaagcaagaa gccttcgcaa ccaggttggt atggtgcttc 864841 aagatacctt tttatttagt gaaacgattc gggaaaatat cgcgatcggc aagcctgatg 864901 ccacacttga agagataatc gaagccgcca aagctgcaaa tgcccatgaa tttatcatga 864961 gttttccaga aggatatgag acccgggtgg gggaacgagg cgttaagctt tcaggcggac 865021 aaaagcagcg gatctcaatt gcgcgggtat tcctgaaaaa tccgccgctc ctcattttag 865081 atgaagctac atcagctctg gatttggaaa gtgagcatta cattcaagaa gcgatggaca 865141 aactggcgaa ggatagaaca acttttgttg tcgcccaccg tttatcgaca atcacccatg 865201 cggataagat tgttgtcatg gaaaacggga caatcattga aatcggaacc catgatgaac 865261 tcatggacta tgagagccaa tacaagcact tatttaccat tcaaaatttg aactaaaaca 865321 tcaatcttat atccttttaa cgaaggatat aagatttttt tgtatataaa aaaacccggc 865381 tgtttaaccg ggttactctt ctgtttctat ttcgcagtct ttcggatgat acgtttgaaa 865441 acttgtgata agtgtttcta aatgttcaag ctgctcgcga tattccacgg cgcttgccat 865501 aatattgagc atgttgtaat caataagctc ctcatccgta ttctgctgat tttttaaaaa 865561 tgactttgtt aaaagctgct tataccggat gccttcttca accgcgtcat catgcggctt 865621 gatttttccg acaaacctca tcaaaatccg ctcgtgccag taaagcaggt aatcaagttc 865681 ttcagtcaat gtttcctgaa actcttccgg catatgatag atctcgtttt ccagacgatg 865741 cagcttcttc aatgtatcaa gcgcccgatt tgcagtaata atggcctgtc tgaacaggac 865801 aagctttctt gatttcacat aagtcgtttt cttaaagtaa cttctttctt ctttatatag 865861 aagatatgtc tgatcaagct tgatcatttt ttctttcagt ttttcaatat cctctttcaa 865921 aatcgaatgc tctgtcgact gccgcatgga caatctgatc cacttcataa tttcttcggt 865981 gttttcgacg gtattatgaa tcagctttgt ttcgtactta ggaggcaaaa acacaaggtt 866041 gacgataaag gaagaaagca cccctaagat gactgtgctt gttctgatca gcgcgaacat 866101 taaaaagtcg tcaccggcag attctaatat cgcaatgact gttacaagag caattgaaat 866161 tgtatgttca attttaagtt tcagcatgat tgtaatgaca ataactgctg ttaacccgat 866221 cataatcggg ctgggtccga aaataaggcc gaacactgtg gcaatcacag ctccgatgat 866281 atttgcttga acctggtcaa taataatgag aaaagagcgg taaatcgacg gctggatcgc 866341 aaatatcgct gcaattccag cgaaaatcgg cgcgggaagc ccgatccacg aagccaaata 866401 aagggcaagt gtaatcgcaa tcccggtttt gaaaatgcgg gcaccaagtt tcattggttt 866461 gtgcgtgcat tcctttctat agtaaattgt gtgacatagc aaatgggcta atccttaaaa 866521 ttcccggtta gtttatttgc taaacaatta agtaatatac agggatcgat acaaatattc 866581 aagctatttt tctagaaaaa gaccaaaatc ttacacgctg tttgattcca taaaaaaaca 866641 ggagctcaaa gctcctgttc aaggtatttg attctagttt tttagatgtt taaatgcatc 866701 ctcgaccgct gtaagcgtgt ctttaatatc ctgctctgta tgtgctgtgg taataaacca 866761 agcttcatac ttagaaggtg ctaaattaat tccgcgttcc agcatcagct tgaaaaacgt 866821 agagaatgtt tctccgtcac tccgttcagc ctgctcgtaa ttttccactt tctcatcaga 866881 gaagtatacc gtgagcgcac cttttaaccg gttgaccgta atggtgatgc cgtgtgtttc 866941 tgcgtgcttc aaaatgcctt cctcaagcat agcgccaagg tgatcaagct tttcatacac 867001 gcctttttct ttgagcactt ccagacaagc gatgcctgat aggatggaag cggggttccc 867061 tgccattgtt cctgcctgat aagcaggccc tagcggagct acctgctcca tgatttcttg 867121 tttgccgcca taggccccaa tcggaagtcc gccgccgata attttcccga gtgctgttaa 867181 atctggtttc acctgtaaga gatcctgcgc gccgccatac ataaagcgga aagccgtaat 867241 gacttcatcg taaataacga gagcccctgc attatgtgtt aattcattta cttgttctaa 867301 gaagccctct ttcggctcca cgataccgaa gttgccgaca atcggttcaa cgagaaccgc 867361 cgcgatttca ctgccccatt tttcaagagc tgctttatag ctatcgatat cattaaatgg 867421 tactgtgatc acttcgtttg caatgctttt cggtacaccg gctgagtctg gtgtgccgag 867481 agtagacggg ccggagcctg cggcgacaag cacaaggtcc gaatgcccgt gatagcagcc 867541 cgcaaattta atgatttttg tccggcctgt atatgcgcga gccacgcgga tggtcgtcat 867601 aacggcttct gtacccgaat tgacgaatct tactttgtcc atagcgggaa tggcttcttt 867661 gagcattttt gcaaatgtaa cctcgtgttt cgttggtgtt ccatacaata caccgttctc 867721 tgctgctttt ttaatcgctt ctgtaatatg cggatgggca tgtcctgtaa taatcggacc 867781 gtacgccgct aaataatcga tgtatttgtt gccgtccaca tcccaaaaat aagcgccgct 867841 tgctttctcc attgcaacag gagaaccgcc gccgactgct ttatatgatc tagacgggct 867901 gtttacaccg ccgacaatgt gctgtaatgc ctcattgtga agttcaattg attttgtatg 867961 caagaataaa aacctcctat atctccatgc gtcctttcta ttgtagcatg cttccgaaca 868021 agaacaatgg cttcgggctt cagattcagc tgagatggtt gtaatctgga caagaattgg 868081 atacgcttaa taaaaaaaca tccggaggta acgtaatgac tatagaaatc ggacaaaaag 868141 cgcctgatct tgagttaaaa ggtgatcatg gggaaacagt aaaattatcg gattataaag 868201 gaaagtacat cgtgctttat ttttatccaa aggacatgac accgggatgt acaactgaag 868261 catgcgattt tcgggacagt cacgaaagct tcgccgaact ggatgccgtc attatcggcg 868321 tcagcccgga cagccaggaa aaacacggaa aatttaaaga gaagcataac cttccatttc 868381 tgcttcttgt tgatgacgag cataagctgg cggaagcatt tgatgtgtgg aagctgaaga 868441 aaaacttcgg aaaagagtat atgggaatcg agcgttccac ttttttaatt gataaagaag 868501 gccggctcat taaagaatgg agaaaagtaa aagtaaagga ccatgtagcc gaagcgcttc 868561 aaaccctcaa agatatgtct gaaaagtaaa tctctatgag cctatgctta cttttaccct 868621 gatatcaatt gacaaattat cgtagaaaga gttacactaa ttataaacat tacaatgtaa 868681 gaattttttt tagaagagag gtgcatgacg gatggctgca catgaactaa aagaagcctt 868741 agaaacgttg aaggaaaccg gagttcgcat tactcctcaa cgtcatgcga ttctggaata 868801 tctcgttaac tctatggctc atccaacagc ggacgatata tataaagctc tggaagggaa 868861 atttcctaac atgagcgtag cgacggtata taacaatttg cgtgtgttcc gggaatcagg 868921 tttggtaaaa gagctcacat acggtgatgc ttccagcaga ttcgattttg tcacatccga 868981 tcactatcac gcgatttgcg aaaactgcgg taaaattgtg gacttccact acccgggcct 869041 tgatgaagtg gagcagctcg ctgcccacgt cacgggcttc aaggtaagcc accaccgttt 869101 agaaatttac ggcgtctgcc aagagtgttc gaaaaaagaa aatcattaaa aataagctga 869161 ccgcacgaaa cggtcagctt attttatttc gacattttct ttttattata agactcatca 869221 aattcttttc cttctaatcc cttatctaaa gtcagcggct ctcggcaatg catgcacata 869281 tcgactactc ctaaaacctt tgtctcttta tcacagcctg gacaaatgac gcgaaccgct 869341 ttagtcgaaa gcattccgat ccaaaagtaa actaccgtgc tgagaccgat ggataaaagc 869401 ccaagtatca taaacaaact agaaagcaaa actgactctt tgaaaaagat cccgatgtac 869461 ataatgataa acccaacgaa aaccaaactt aacgcaaatg ttctgatttt attaattttg 869521 ctggagtatt tcgccatgtc catccccctc tgttttaact atagcacaaa cccgatggga 869581 ttttcttcat gttttcggtt gaactggaat ttacatatgg agagttactg tgaaattgtt 869641 tataatagtt caatgtgttt agaaaaaagg aatttcgttt taaccataga attgaatcaa 869701 atagagaata aaaaaatttg aacaattgca ttggaggaat agtgatggaa aatcttctcc 869761 gtccaattta ccaagaaaga gcaagtcacc ccaatacatt ggctgtcatt atgattgaga 869821 gaagaaacaa aacatcttcc ttaacagata actttgatgc agctttgctg gtgattgtaa 869881 aggatgctga tgagccagtt tttataaagc attatgaatt tgatcatcaa acagcttctt 869941 tgcatgtggt aacagattct cagattcaag aatggatttt gcttggaaca aatagaagaa 870001 tcatagattg gattgtaaat ggcagagtct tgtttgaccg taatgaatac gtagttgaac 870061 tgattgacag gctgaataca tttccgtttg ccgaacgtaa actgaagatc ggactcgaat 870121 acggcaaatt aatcagaagg tatgttgaag ggaaagcttt ttttgaagcc aatcaatttt 870181 tagatgccta caatgccgtt gttcatgcgc tgcatcattt agcacgtatt gaagtaatcg 870241 acagaggatt ccatcccgaa accacggtgt ggagccaagt gcgccagatg gagccccaag 870301 tgtacaaatt atattccgag ctgattgaaa gtcatgagag cctggaaaaa agacttgaat 870361 tattattctt agcaaatgat tttctcatcc attccaaagc cgagatcggt tcggcgcatc 870421 ttttcgaagt aatgaaagaa aaagacattt ggcaattcgg tgagcttctt caacatcatg 870481 acctaaagca ctttacccaa gatcttggcg ttatgcttga ttacttgacg gaaaagggac 870541 ttatcaacgt ctgccagata gaaacgaaag gacaggctgt ctatcaccga ggatattctt 870601 ttaaaaaagg tgttgactct gattcttgac cgtgttatat tattaaacgt cgctgatgcg 870661 cttctgagaa aacaagctca cagcggcggg aaaataaatc aaaaaaacat ttgacaaaag 870721 aaagtcaaaa tgttatatta ataaagtcgc ttcaacaaga agtgaaaatg atctttgaaa 870781 actaaacaag acaaaacgta cctgttaatt cagtttttaa aaaatcgcac agcgatgtgc 870841 gtagtcagtc aaactagggc ctgcacgacg caggtcacac aggtgtcgcc gcaggatgcg 870901 gtgaacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg acgaacgctg 870961 gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc ctgatgttag 871021 cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata actccgggaa 871081 accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa aggtggcttc 871141 ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta acggctcacc 871201 aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac tgagacacgg 871261 cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa agtctgacgg 871321 agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa 871381 caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc cacggctaac 871441 tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat tattgggcgt 871501 aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca accggggagg 871561 gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca cgtgtagcgg 871621 tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg gtctgtaact 871681 gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc 871741 gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca gctaacgcat 871801 taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat tgacgggggc 871861 ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc 871921 ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga gtgacaggtg 871981 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 872041 acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc cggtgacaaa 872101 ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg gctacacacg 872161 tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat cccacaaatc 872221 tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat cgctagtaat 872281 cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac 872341 cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca gccgccgaag 872401 gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg 872461 atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta taaacagaac 872521 gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct ttgaaaacta 872581 gataacagta gacatcacat tcaattagta atacaagata tcacatagtg attcttttta 872641 acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg atgaaggacg 872701 ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga gatttccgaa 872761 tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata ggatatgaga 872821 aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc aaatgcgatt 872881 ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc ctcttggggt 872941 tgtaggacac tctgtacgga gttacaaaag aacgaggtag atgaagaggt ctggaaaggc 873001 ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag tggatcctga 873061 gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc aaggctaaat 873121 actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag caccccggaa 873181 ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc gttaacgggt 873241 gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag gttaagcaga 873301 agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt ggtcgtagac 873361 ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg aatggaggcc 873421 cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc 873481 gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca aggtaagagt 873541 cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa 873601 ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga tccgtagtcg 873661 aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag tggaaaagga 873721 tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt taaagagtgc 873781 gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta aacgtatcac 873841 cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc tgtgaagcca 873901 gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg 873961 ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg 874021 ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc 874081 tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg taagcgcggt 874141 attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt tcccataagg 874201 ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca ctgccaagaa 874261 aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag 874321 aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac cccgtaactt 874381 cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga ataggcccag 874441 gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta taggggctga 874501 cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg tgcgaattga 874561 agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat tccttgtcgg 874621 gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac gagagactcg 874681 gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa agaccccgtg 874741 gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata ggtaggagcc 874801 ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc tggctgtatt 874861 gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg cagtttgact 874921 ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag aatggttgga 874981 aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac aagtcgagca 875041 gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat cgctcaacgg 875101 ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat cgacggggag 875161 gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc caagggttgg 875221 gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag acagttcggt 875281 ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg agaggaccgg 875341 gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg tagctatgtg 875401 cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat gagatttccc 875461 attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg aggtggaagt 875521 gtggcgacac atggagctga cagatactaa tcgatcgagg gcttaaccat atttttgaat 875581 gatgtcacac ctgttatcta gttttgagag aataagtttt tcaaaaaaac acttgatttt 875641 ctcaagaata catagtataa tgttaaatgt cactgaaatt gtctggtgat gatggcgaag 875701 aggtcacacc cgttcccatg ccgaacacgg aagttaagct cttcagcgcc gatggtagtc 875761 gggggtttcc ccctgtgaga gtaggacatc gccaggcaga cttcattccg cagtagctca 875821 gtggtagagc tatcggctgt taaccgatcg gtcgtaggtt cgaatcctac ctgcggagcc 875881 attattggag agctgtccga gtggtcgaag gagcacgatt ggaaatcgtg taggcggtca 875941 actccgtctc aagggttcga atcccttgct ctccgccact gatacttata cataattaca 876001 attgaaagtc tgggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca 876061 cgggttcgaa tcccgtacgg gtcattatat gatggaggat tagctcagct gggagagcat 876121 ctgccttaca agcagagggt cggcggttcg agcccgtcat cctccaccat tatatcatcg 876181 cggggtggag cagttcggta gctcgtcggg ctcataaccc gaaggtcgca ggttcaaatc 876241 ctgcccccgc aaccaaattt taaaatggtc cggtagttca gttggttaga atgcctgcct 876301 gtcacgcagg aggtcgcggg ttcgagtccc gtccggaccg ccatttgaat acttaggctc 876361 ggtagctcag ttggtagagc aacggactga aaatccgtgt gtcggcggtt cgattccgtc 876421 ccgagccacc acctatgccg gtgtagctca attggtagag caactgactt gtaatcagta 876481 ggttgggggt tcaagtcctc ttgccggcac tgttttttca aaatttaatg tggaggggta 876541 gcgaagtggc taaacgcggc ggactgtaaa tccgctccct cagggttcgg cagttcgaat 876601 ctgcccccct ccaccattta taggggcata gtttaacggt agaacagagg tctccaaaac 876661 ctccggtgtg ggttcgattc ctactgcccc tgccaaattt atgacatctt gagattatgg 876721 cggttgtggc gaagtggtta acgcaccaga ttgtggctct ggcactcgtg ggttcgattc 876781 ccatcaatcg ccccatatta tcattgggct atagccaagc ggtaaggcaa cggactttga 876841 ctccgtcatg cgttggttcg aatccagcta gcccagtctc actttttata tcaactgcat 876901 ataatgtatt aagtccatta aaaatgcgga agtagttcag tggtagaaca ccaccttgcc 876961 aaggtggggg tcgcgggttc gaatcccgtc ttccgctcca attacggcgg catagccaag 877021 tggtaaggca gaggtctgca aaacctttat ccccggttcg aatccgggtg tcgccttctt 877081 attgccgggg tggtggaatt ggcagacaca caggacttaa aatcctgcgg taggtgacta 877141 ccgtgccggt tcaagtccgg ccctcggcac caattttact tacatggtaa gttgaattgg 877201 tgtttgtgtt ttatcattat aactaatcat attaatgatc tacataagta gatcattttt 877261 ttaatgcttt gatttatcat aacaagttaa gttccgaggc ctattataaa gcggctgtat 877321 agctagtctt tcaacacttt tattttatat ttccataaaa acttttttga aatacgttga 877381 cactttatga gatccatgat atatttatat tcgtcggtta gatacgacgt aaaacttgcc 877441 ggtgtggcgg aattggcaga cgcgcacgac tcaaaatcgt gttccttctg gagtgtcggt 877501 tcgaccccga ccaccggtat actgaaaaac ccgtttctta acagaaacgg gtttttattt 877561 tttattaaag aaaaggagcc tcggctcctt tttatactta ctcagcgtat tggtctagga 877621 tctcttctag cacctcttct agctcttctg tatcttcaag ctctgattgg ctgaaacgga 877681 cgcgtacaag ctgttctccg tcattataca tctcttccaa ccaccctcgg agtcctcttg 877741 ctctgcggtc gacttcgaaa atgatttcca aaccgtcttc gtctaaaagg aaaatgagct 877801 ctaattcatc aagcatctga cgataatatc cggaagtcgg aacgaattcg aattcttgaa 877861 cgaacggaag acgacgctgg aagtagggcg cttgttcgca gtctgcttcg ttaagacgga 877921 agcccaggtt ttcgattgct tcaagcacat tttcaatcca agggtgcgct tcaacgaaaa 877981 tgcggtcatg atcggattta tcgataccgc cttgaatgtc aaggtctgtc accacggcaa 878041 cctctacttt ccctacagtg atcggcgtat ctagaggcag agtgaatgtg aacggaaatt 878101 gatgctcttc accaggctgt atggtaaatg aaccagtgac ccggaaagaa tgaattgtag 878161 cgtatttccg gtgctcttca tcgtctttta caatgacata ccgtgtgcta agctgtaaat 878221 cgatataacg gatgtcctga gcgatttttc cgcctttgac atgtaccgtt ccctgtactt 878281 cttctcctgg aaaatatgcg tctttttcta aaattgtatc tacttttgca gctccaattc 878341 cggcacttgc cgcaagcttc ttaaaaaatg acatgttaga tcttcccctt tttctttttt 878401 ctcaacagat atacgtaaga aggaggaaaa aagattcgtt tgattcatac ttttttccta 878461 ttattcgtct cggcctaggg acagactaag aataatattg aaaataaagg agtcgatgga 878521 agtgaataaa gaaagtttgg ttgcagatga attacacaga atgtttttgg ctggtgagct 878581 gcaaatcaca gtagaggagg atataaacaa tatttccgaa aggctgagaa acggcgatct 878641 cagtttagac cgattaagcg gtgaagacgt gtttataaaa gaaacggtaa atgaggcttt 878701 aagaagagtg gagcaataaa aaagagacgg catctcatct ttgagatccc gtctcttttt 878761 gtggtctttg ctgtaagata aaagcgaatc gatttggaat tgctcacccg agccacccct 878821 tttctaacag aagatctgac agttcatcat ggagataaac agctgtatct aattgatcat 878881 gcaatgctct tctgatgtgg ggattttcgg ttgctgttgt tgcgacagtg tatttgttaa 878941 tgctggtttt tattgttgtt aacaaatcaa gaatatcttt gggacaaaga ctttgttcaa 879001 tgggaaacca cctcctttgt ttttttagca gctcctgata agaaagtatt tgactttgtt 879061 tcttgcttct atacaaaatg ctataataag caacaaattt tgttgggggg tgtgatgatg 879121 aagcagatta ttgcgatggg gggcgggggt ttttcgatgg agccggataa tttgtccctc 879181 gatcaatata tcctcaatca atcaaaacga gagcagcctc gtatttgttt tttgccgacg 879241 gcgagcggag attcccaaaa ctatattcag cggttttatc atgcatttca aacattggat 879301 tgcgtgccgt ctcatttatc tttgtttaag ccaccatcat cagatttagt ttcttttgtt 879361 atggaaatgg acgtgattta tgttggcggg ggaaatacgc ggaatttact tgtgttatgg 879421 aaagagtggg ggctggacca tattctcagg gaagcatgga agaacggtgt ggttgtagct 879481 ggaataagtg ccggtgcgat ctgctggttt gaagaagggg tgacagattc agccggaccg 879541 ctgacaagtt tgaaaagttt aggttttttg caagggagct tttgtcccca ttatgacggg 879601 gaaaaggatc ggagaccggc ataccaccag ctgatatcta acaagttctt atgcagtggc 879661 tatgcagcgg atgatggggc tgctctccat ttcataaatg atcagctgtt tcagactgtg 879721 agttcaaggt cgggtgcaaa ggcatatcgg gtgatgatgg ctgaacatga aatagctgaa 879781 atcccgttgc cggtcaaata tttagggtga aattggctga atattatcta tattcctctt 879841 tttttcagat tgattttatg ataagatgag tgcgaaatca atagttactg ggggtgcccg 879901 ctttcgggct gagagagaag gcaagcttct taaccctttg gacctgatct ggttcgtacc 879961 agcgtgggga agtagaggaa ttgtttttgt tattgtcttg ctgggcaata atatgtttct 880021 ttctgactgt aaccgggttc atttatatga atccggtttt ttgtgctggt tatgggcttg 880081 attttgtcct ttcaaacgta gaaaggggaa ggaaaagtaa tgcaaaacaa ttcagtgcag 880141 caagccaaca tttccattat gtcaagtttt tcaggcagca agaaggtata cgtggagggt 880201 tcttcttcgg acatccaagt gccgatgagg gagattgcat tgagtccgac gacgggatcg 880261 ttcggcgaag aggaaaacgc gcctgtgcgt gtctatgata caagcggacc gtatacggac 880321 cctgaagtaa ccattaatat tcaagaagga ttaaagccgc tccgccaaaa atggatcaca 880381 gagcgcggtg acgtggaaga gtatgaaggt cgggctataa aaccagaaga taacggttat 880441 aaaaaagcaa aaccaaacgt aagctatcca ggattaaagc ggaaaccgct gagggcgaag 880501 gcaggtcaaa atgtcacaca aatgcactat gcaaaaaagg ggatcattac acctgagatg 880561 gaatttatcg ccattcgtga gcatgtgtct cctgaattcg tcagagacga ggtagccagc 880621 ggccgggcga ttattccttc aaacattaat caccctgaaa gtgagccaat gattatcggc 880681 cggaattttc atgtgaagat taatgcaaat atcgggaatt cagcggttac gtcatccatt 880741 gaagaagaag tggaaaaaat gacgtgggcc atccgctggg gagcggatac gatgatggat 880801 ctctctaccg gaaaagatat tcatacgacg cgtgaatgga ttatccgcaa ttgccccgtg 880861 cctgtgggaa ctgttccgat ttatcaggcg cttgaaaaag taaacggcgt agctgaggat 880921 ttaacgtggg agatttatcg tgatacgcta atcgagcagg cagagcaggg agtggattat 880981 tttacgattc acgcgggtgt tttgcttagg tatgtaccgc tgactgccaa acggacaact 881041 ggtatcgtgt cacgcggggg agcgattatg gcgcagtggt gtctggctca tcatcaagaa 881101 agctttttat acacacattt tgaagaaata tgtgagatta tgaaaatgta tgatattgct 881161 ttctctcttg gggatggttt gcgtcccgga tcaattgctg atgccaatga cgaagcgcag 881221 tttgctgaat tagagacgct tggagagctg acgcaaattg cctggaagca tgatgttcag 881281 gtgatgattg agggtcctgg acatgttccg atgcataaaa tcaaagagaa cgtcgataaa 881341 caaatggaca tttgtaaaga agcgcctttt tacacattgg ggccgttgac aacggatatt 881401 gctccgggat atgaccatat tacttcagcg atcggagcgg cgatgatcgg ttggtacggg 881461 acagcaatgc tttgttatgt aacgccgaag gagcatttgg ggctgccaaa ccgtgatgat 881521 gttcgtgaag gagtcattac atataagatc gctgcgcacg ctgcggacct tgcaaaaggg 881581 catcccggag cgcaaatccg ggatgatgcg ttatcgaaag cccgttttga attccgctgg 881641 cgggatcagt ttaatttatc tcttgatccg gagagagccc ttgaatacca tgatgaaacc 881701 ctgcctgctg aaggagcaaa aaccgctcac ttttgttcca tgtgcggtcc gaaattttgc 881761 agcatgagaa tttcacagga tattcgggat tatgcgaaga aaaacgatct cagtgaagca 881821 gaagccataa ataaaggatt aaaagaaaaa gcaaaagagt ttgtcgatac gggaagcaat 881881 ttatatcaat aaaaaaaatg aagatggaga atgctccatc ttcatttttt tagaaaaaca 881941 gagagcgtcg aagcggagga atactctgtt caaagcggaa aacattttct ggatcatatg 882001 tcgttttgac acggcggagt cgttcaacgt tttcgccgta atatgttctt ggccagtttc 882061 tgatttcgat atctggccaa tttacgtagt ctcccatcgt ttctttcgaa agggacgttc 882121 tcagcccctc aatccagcgg acattttgtc ttttttctcc aggggatgtc cagtttgtta 882181 agtattcctg ggcgatgatt gcgtcacgat aataaaatgc cgtttggtcg ggagcgaccc 882241 gtccggctgc cccgccgagt gcttgctgcc agacactggc gttttgattc ggagcgtgct 882301 ctaaaaagtg ttttattgtt gagatcgcac gttctgataa tggcttttca atgaaagagc 882361 cggagcgttt cattttttga ggctgattgc ctcccgggct gttaaaaaag gttaccgctt 882421 caatgaatgg cgttgttttt accattccgc ttgtcggact tcctgctttc aataaaggct 882481 ttaacagttt ttttaactct gtttttggcc cgacaaattg gccgagggct tctatgcggt 882541 ttacttcttt aggccaaaac tctattgatg atgtaagccg gtcatctgta tacggggccc 882601 agttctgcca cgtgttatat acttcctcaa aatcatccca tccccatgta atagaaaaaa 882661 tcgacacttg agagatgggc actgctttaa atgtcatgga ggtgactatg ccgaaattgc 882721 ctcctccgcc tccctgagac gcccaaaata agtctggatg atttgaacag ctgactgtaa 882781 tcagatcagc gccctctttt tcgtctgcta cgatcatctc aagctgcacg aggctgtcgc 882841 aagtaagacc ggcagccctt gttaaaagtc caattccccc tccgagagtt aaacctgtga 882901 gccctacatt agcaatggtg cctgcgggaa gcgtcaggcc gtattgccag agtgtccgat 882961 agacttctcc caattcagcc cccgcttcaa tataggccag ctttttatcc tgattcacag 883021 ttattttttt catctcgctt aaatcaataa caagaccgtt atttaaaagg gaaaagttct 883081 catagctgtg tctgccgcct ctaatacgga aaggcacacg gttttcacgc gcccatttca 883141 gcgcattgag tgcatcctgt ttgttttggc aaaacacaat gatgtcagga tacctttcta 883201 agcttaggtt aatattggtt cttgcttcgt tatagtccgg atcatcccgt gtcacgatac 883261 gtccggtcaa ttttgtcttt tccacactcc cacatctctt tctctcgtat tctagtttct 883321 ctagcttatg cgtcagggga aaagagtgta taaggaaaaa gcggggatgc aatctgatac 883381 agtgtcaaca ccctcaaaaa atagttgaca ggtcggtatt gtatgaatta acatggtcag 883441 tacaaatttt tcaaatttat cgcgctgatc ggaacaccga aggctcttat cgtttagata 883501 agggcctttt ttgtatgaaa aaggggggat tattgatggg agtcaaaaaa gaaaagggga 883561 gaaaacgatt caggaagcga aaaacctacg ggaatcagat tttgccgctt gagctgctga 883621 ttgaaaaaaa caaacgagag attataaaca gcgcggaact catggaagaa atttatatga 883681 agattgatga gaagcatacg caatgtgtaa ctaaatataa aaaaacccgc tgactacaac 883741 gggtttttgc atttctccat taagaatctt ttttaatcgg caatccaagg ccttctgcca 883801 cgcgttttcc gtattcagga tccgctttgt agaagtgctc gatttggcgc agcttgattt 883861 cttctttttc taccggcttc atggcattaa cgatattttc aacaaggcgg gtacgttcat 883921 cttcactcat taaacgatac agatcgccgg cttgagtgta gtgatcgtag tgatcgtagc 883981 ttacgctgtc agcgatacct tgtaccggat atgctgcttg cttatcctca ggtgactctt 884041 ttggaccgcc gaagctgtta ggctcgtaat acacagatcc gccgccgtta tcatcaaaac 884101 gcatttgccc atcacgctga taattgttta ctttgttgcg tgcgcggttg attggcagcg 884161 cttgatggtt tgcaccgaca cggtagcggt gtgcatcatg ataagcaaaa agtcgacctt 884221 gaagcatttt atccggtgaa acatcaatac caggcacgag ggttccaggt gaaaatgtcg 884281 cttgttctac ctctgcaaag tagttttccg gatttctgtc tagaaccatg cgtccgacct 884341 cgattaacgg gtagtctttt tgagaccaaa cttttgtgac atcaaacgga tcgaaacggt 884401 acgtatttgc atcttctaaa ggcatgattt gcacatatag tttccatgca ggataatcac 884461 cgttttcgat tgcgttgaaa aggtcttctg tatggtaatc agggttttca ccggcaattt 884521 ttgctgccgt attgacatca aggtttttca cgccttgttc tgttttaaag tgatatttaa 884581 tccatacgcc ttcgccttcg gcatttgtcc atttgaatgt atggcttccg aagccgtgca 884641 tgtggcgaag tgtcgcagga attccgcggt cagacatcag gattgtcact tggtgcagtg 884701 actctggtga aagtgaccag aaatcccata cagccgtagg gtttttcagg tgtgtttttg 884761 gatctctttt ttgtgtatgg atgaaatcag ggaacttaat cgcatcgcgg ataaagaata 884821 caggcgtatt gttgccgacg atgtcgtagt ttccttcttc agtataaaat ttaacagcaa 884881 atccgcgcgg gtcgcgaact gtgtcagcag agccaagttc accggcaact gttgagaaac 884941 ggatgaacaa cggtgtgcgt ttgccgactt cagaaaggaa agcggctttc gtgtattttg 885001 ttacgtcgtt tgtcacttca aaatatccgt gtgcgcctgc tcctttggcg tgaacaacac 885061 gttcaggaac acgttctcgg ttgaaatggg ccaatttttc gagtaaatgt acatcttgaa 885121 ttaaagttgg tccgcgagaa ccggcagtca ttgagttttg attatctcca accggagcgc 885181 cccagctagt tgtcagttta tttgaactca tgttatcacc tcttggaatt tataagaaca 885241 taatatcatc tctaagtaaa aagtcaatat tattttataa ttattataaa atagttatct 885301 ctattaatcg atatatagta tcgaaattgt tgaaaaacct tgttgtaaca gctttttatg 885361 acacttaata atttttggag aaataatttt tccttctcta tttgcgaaac aagcagagta 885421 agtgataaac aaggatatca aaaatcgtat ttaaaaaaga gttgacatat cggaataatt 885481 tgaattaaca tgttattcaa acaaaaaaac aattgggcag ctgatcggac cgccgaaggc 885541 tctcatctct acaagaacag agatgggggc ctttttgttt tttttgaagg cggggttggc 885601 agaaagagag ggataaaagt ggctgtgacc atcagcatca aagaaaaggc atttgttcaa 885661 gaaggccgca aaaacacggt cttagaaaac atagaattat caatcgcacc aggcgaattt 885721 ctaacgctta tcggaccgag cgggtgcgga aaaagcaccc tgttaaagat tattgcaggg 885781 cttgattctg aatatgacgg gagtgtggaa attaacggcc gcagcgtaac agctccgggt 885841 attcagcaag gatttatttt tcaggaacac cgcctctttc cttggctgac tgttgagcag 885901 aatattgcag ccgacttgaa tttgaaggac ccaaaagtca aacaaaaggt ggatgaactg 885961 atcgagattg tcagattgaa aggatcggaa aaagcatatc cgcgcgagct gtcaggcggc 886021 atgtcacaaa gagtagccat cgcccgggcc ctgctgcggg agcctgaggt gctgctttta 886081 gatgaaccgt ttggtgcact cgacgctttt acaagaaaac acctgcagga cgtgctgctg 886141 gatatatgga ggaagaaaaa aacaacgatg attctcgtga ctcatgatat agatgaatct 886201 gtttatttag gaaatgagct tgcgatcctt aaggccaaac cggggaaaat ccataagctg 886261 atgcccattc acctggcgta tccgcgaaac cggacgactc cggatttcca agcgatcaga 886321 cagagagtgc tgtcggaatt cgagaaaaca gaagatttgg agtacgcaga aggatcaggg 886381 atatagaaag ggcggaagcg gaaatgaaaa aaggactcat tgtattggtt gccgttattt 886441 ttctgctcgc aggctgtgga gcaaatggag ccagcggtga ccacaaacaa ttgaaggaaa 886501 ttcgtattgg tattcagcaa agcttaagcc cccttttgat tgcaaaagaa aaaggctggt 886561 tcgaagatgc atttgaaaaa gaaggcatca aagtgaaatg ggtggagttt caaagcggtc 886621 cgccccaatt tgaaggcctt gcggcagaca aacttgattt ttctcaagtc ggtaattcgc 886681 ctgtgatcgc tggacaggcg gcaggcattg actttaaaga aatcggtttg tctcaggacg 886741 gcttgaaagc aaacggcatc cttgtcaatc aaaacagcgg cattcaagac gttaagggct 886801 taaaggggaa gaaaattgca gtcgccaaag gcagcagcgg gtttgatttt ttgtataaag 886861 cgcttgatca agtggggttg tcagctaacg atgtgacaat tattcagctt cagcctgatg 886921 aagcagcttc cgcatttgaa aacggatctg ttgatgcctg gtccatttgg gagccgtact 886981 tgtccttaga aacaatgaaa cacggagcaa aaatccttgt gaacggagaa agcacagatt 887041 tatattcacc gggttttact ttagtaagaa caaagttttc agaagagcat ccagacgaag 887101 tggtccgttt tctgaaggtg tttaataaag ccgttgtatg gcaaaaggaa catctggatg 887161 aagcagcgga cttatattct gacattaaag atctcgataa aaaggtcgtc gaaaatgtgc 887221 tgaaaaatac tgagccactt aatgagatca tcagtgacga cattgtgaaa gcacagcagg 887281 aaacagcaga ttttcaattt cgaacaaagg cgatagataa gaagattgat gtgaaggatg 887341 ttgtcgataa cacttttatc aaaaaagcat tagaggagca ttcctcagga ggtgatcaat 887401 gatgaaagca gaggctgcgg gctcgctgcc caaaacgaat gcggaagcgg tgcgaaaaaa 887461 gcccggaagg aagagatacg gctggatgaa ggggctttta ctgcccgctg tcatcattgc 887521 catctggcag gtcatcggcg ggctgggggt tgtgtccgct acagtgctgc ctacacctgt 887581 tacgattgtt ctgaccttta aggagcttat tttgtccggc gaactgttcg gccatctgca 887641 aatcagcatt tatcgggcgg cacttggttt tttgcttggc gcggggcttg gattgatgat 887701 cgggattttg gccggatttt ccaaacggac ggagctgtat cttgatccgt cgttgcaaat 887761 gcttagaacc gtacctcatc tggccgtcac gccgctgttt attttatggt tcggatttga 887821 cgaagtatct aaaattttgc tgattgcgct cggtgccttc tttcctgtct atatcaatac 887881 gtttaacggc atccgcgggg ttgacgcgaa gctgtttgaa gtcgcccggg tgcttgaatt 887941 taaatggcat cagcagatat ccaaagtgat attgccggca gccctgccca atatattgct 888001 aggcattcgc ttatcgctcg gcattgcatg gctcgggctc gttgtggcag agctgatggg 888061 ctcaagctcg ggagtcggct atatgatcat ggatgcgaga cagttttcac aaacgaataa 888121 agtctttgca gggattatca tttttgcagt ggttggaaag ctgacggatt ccttcgtcag 888181 gctgcttgaa cgaaagctgt taaagtggag aaacagctac gaaggataaa agatataaag 888241 gggagatgaa tatggaaatt ctttggttta taccgactca tggagacgcg agatatttag 888301 gatctgaaag tgatggacgg actgcggatc atctttactt taaacaagtc gcgcaggcgg 888361 cagacaggct gggatataca ggagttcttc tgccaacggg aagatcgtgc gaggacccgt 888421 ggcttacagc gtcggcactg gcaggagaaa caaaggactt aaagttttta gtcgcggtaa 888481 gacctggttt aatgcagcct tctctggcag ccagaatgac atccacccta gaccgcattt 888541 cagacggccg gctgctgatc aacgttgtgg cagggggcga tccgtatgag ctggcaggcg 888601 atggcctgtt tatcagccat gatgagcgct acgaggcaac agacgaattt ttaaccgttt 888661 ggcggagact tttgcaggga gaaacggttt cctatgaagg aaagcatata aaagtggaaa 888721 acagcaatct gcttttcccg ccgcagcaag agccgcatcc gcccatctat ttcggtggtt 888781 cgtcacaggc tggaattgaa gctgccgcaa agcatacaga cgtgtacttg acatggggtg 888841 agccgcctga acaagtaaaa gaaaagatag aaagagtcaa aaagcaagcg gcaaaagaag 888901 ggagatccgt tcgatttggc attaggctgc atgtcattgc ccgtgaaact gaacaagagg 888961 catgggaagc ggcagagcgc ttgatcagcc acttggatga tgacaccatt gccaaagcgc 889021 aggcagcttt gagccgttac gactcttcag gccagcagcg gatggccgtc cttcatcaag 889081 gcgatcggac gaagcttgaa atcagcccga atctgtgggc ggggatcggc ctggtcagag 889141 gaggggcagg aacagctctt gtcggtgatc cgcagacgat tgccgaccgg atagcggagt 889201 accaggcact cggcatagaa tcgtttatat tctccggcta tccgcattta gaagaagcgt 889261 attattttgc agagcttgta tttccgcttt tgccgtttga aaatgatcgg acgagaaagc 889321 ttcagaacaa aaggggagaa gcggtaggaa acacttattt tgtcaaagag aaaaatgcat 889381 gagtttaact aaaatacagc cccccgaaca tggtatgata ttcaaaaaaa gggggctttt 889441 tttctgaaaa cattgagaag cgcggcagtc atttgcctca tagctatgct gtcagcatgc 889501 ggacattcaa aacagatgga aatcaaagcg gcggacatat cagatcttga aaaaaacaga 889561 atggatgtcg cagcttcaca ggcattcact gccgaagccg tcaatatcgg tgaaggtatt 889621 tcttcagctg acatgtacat cgaacattat caaaagggaa agcttgttga gaggtttgga 889681 ccggttcgtg cagattattc agaggaaaaa actgatacca tacaatttgt ttattttgag 889741 aatgaagagg gggaaggaaa gaataaacat accaccattc attttggcat tgtggataaa 889801 cagggaacta tagcggctga ttcatcggtg aaacgcgacg atagcacaac acaggaaatg 889861 actcagaata tttcatcgcc ggaaccgatt actttcgaga agcctgcttt gatcggcagc 889921 agtattagag ggactgacga gacaatgcac acctctgaac ataaaaaaga gctcattaag 889981 catcaagatg cgttactgta ttatgtggaa ttgcatcatt agaatgggcg gcttcaggcc 890041 gtctgtttta caaagcggta tgcttgcttt tttgaatggt gaatgataca ttttaaatcg 890101 taacaatttc gatttaaagg gaggctatgt gacttggcta aaaaatcaaa agtggcaaaa 890161 gagttaaaac gccaacagct tgttgagcaa tacgctggta ttagacgcga gttgaaggaa 890221 aaaggagatt acgaggcact cagcaagctg ccaagagatt cagcaccggg aaggcttcac 890281 aaccgctgca tggtaacggg gcgcccgaga gcatatatga ggaagtttaa aatgtccaga 890341 atcgctttca gggagctggc ccataaaggc cagattcccg gtgtgaaaaa agcaagctgg 890401 taagaaaaaa ctccggccga ttacagcgcg ccggagtttt tttcgttttt cttgaaagag 890461 atgacgtagg aaaggtgctg gatgatcatg atgataaaca caataataat agggaaaaac 890521 ggaatgcgcg attgaaatag cggataaaaa atgagaagaa ccgctgcggc aggcagcgag 890581 aagtagacag cgatatatga cgcgcgacat gcttttgccg tcatcatctg ctctctttca 890641 tcctgctctt caaactcatc aggcagaagt agctgctttc tggcagggcg gctttttttc 890701 tgtaagtaca aataaaccgc agacgccgca acaaacagaa taaagggagt gaggtttaaa 890761 tcaaatacca tcccgccgct ctttgtgccg aaaaaagatg ctatgccttc tgaggcttca 890821 aagtatgaaa tcagcgccca gcatgcaagg ccaaataaaa caaggtgaaa agctgctttt 890881 gttttcatgc tcatcttagt tttcctcctc taaccaaaag acatcctcca ttttcatgga 890941 gaaggctttg cagattttca gtgctaacag cagtgaggga acataatcgc ctttttcaat 891001 cgctgccaca gtctgtcttg tgacgccgac cgtttctccg agtttttcct gagaatagcc 891061 gaagcgtgcc ctcagctctt ttactttatt tttcatcatg acgtctgtcc ccttcacaat 891121 ctcgattgat tatattgtat agtatactta acattatgta aatggaactt aacaacttta 891181 caaaaagata actttttttc gacaaaattt ttatattccc ttgacgaaaa ataaataaac 891241 atgtaatata aaaaaagtca gagcggtact gttgctgaca atcacaaatg cgggtgtagt 891301 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 891361 ccatacatac gttattaacg cagtgtttcg tttctcagat aaacgaagta ttgcgttttt 891421 ttatgtgaaa aagaacacgg tattcgtgtt cttttacgta agccaatgta ctgtatgggt 891481 gccgccgtga atttgttcaa acattttcgt taatgatgat aagaggttaa cagcgctgct 891541 tttctcaatc gatggcggga aaaaaatgat ttgcagcata ttcttagtct cgtttgaaac 891601 gggatagtgg ttgacgctgt ttttgaaatc gccaaaaatg ccgttttcat cagagaaaag 891661 cagtatgttt tctttttctc ccaatgagat ccggaccggc tcatgaagct ttccggcatc 891721 ataaatcata ataggcagag aatattttaa tgcgaaaaaa tcgattgtgt catgggccga 891781 gtctttactt tccatgaatt gttccttgga tatcgggacc agcatgtcct ccattggggt 891841 tgtttctccc tcaaatgaag ggttaagctg tttaaagagt ttctgccatt ccttgacgaa 891901 ggattcatcg gatataccgc cgtccgcata gtcgaaaaac aaggattctt gaaacaggcg 891961 gagtctgcct ttcagcattt gcggtgagga gccgacttcg atattctcat aaatgacagc 892021 agctgcatgt aagccggccg cacgttcagt aataacagaa tcaagtttga tattcactag 892081 cattcactcc agttacgtga tatcaaccta ttataaacgc tgtgtcgttt tatcacaaag 892141 aaaggaggct gtgcaaaaca tgaacgttta tcagctcaaa gaagaattaa ttgaatacgc 892201 gaaaagcatt ggcgtagaca agattggttt tacgaccgct gatacttttg acagtttaaa 892261 agaccgtttg attcttcaag aatcactcgg ctatctctcc ggctttgaag agccagatat 892321 cgaaaaaagg gtgacgccga agcttctttt gccgaaagcg aaatcaatag tggcaattgc 892381 tctcgcatat ccttccagaa tgaaggatgc gccgagaagc acgagaactg agcgcagggg 892441 cattttttgc agagcttcct ggggaaaaga ctatcatgat gtgctgaggg aaaagcttga 892501 tctgctggag gattttctaa aaagcaagca tgaggatatc agaacgaagt caatggttga 892561 tacaggtgaa ttgtctgatc gcgccgttgc ggaacgtgcc ggaatcggat tcagtgcgaa 892621 aaactgtatg atcacaacac ccgagtatgg ctcttatgtg tatttggcgg aaatgatcac 892681 aaatatccct tttgagcctg atgtgccgat tgaagatatg tgcgggtcct gcacgaaatg 892741 cttggacgcc tgcccaacgg gagcactggt taatcccggg cagcttaatg cgcagcgctg 892801 catctctttt ctgacccaga caaaaggatt tttgcctgat gaattccgga caaaaatcgg 892861 aaaccgcctg tacgggtgcg atacgtgcca aacggtatgc cctctcaata aagggaagga 892921 ttttcatctt catccggaaa tggagcctga tcctgagatt gccaaaccgt tattgaagcc 892981 gcttttggcc atcagcaatc gggaatttaa ggagaaattc gggcatgtct caggttcttg 893041 gcgcggaaaa aaaccgattc agcgaaacgc cattctcgcg cttgcccatt ttaaggatgc 893101 ttccgcactg cctgaattga cggaactgat gcacaaggat ccgcgtcctg tcatcagggg 893161 gacagccgca tgggcaatcg gaaaaatcgg agaccccgcc tacgcggaag agcttgaaaa 893221 agcgctggaa aaagagaagg atgaagaggc aaagctggaa attgaaaaag gaattgagtt 893281 gctaaaagct tcaggcatga ctaaacaagg cctgtcctga catacgtata gagcagaagg 893341 aaaaaacact tgagatcatc caagtgtttt ttctctataa aaaagtatgg cgggtggggt 893401 gagcttgaag tacattttag aacaattagc ggaggagcgg ctgggctttc tggttaacgg 893461 gcatgctatg agacaggagt ctcaagtcgg agaccttaaa gtcatggagc gtaagaaaaa 893521 gcttctggaa aaacgtaaag ttgacatcat aaaagcgaaa gcaaaggccg tgattaatca 893581 tgtgcgggtt gaggatgacg gaacgacctg cctttcgtat accatccatt acgaatacgt 893641 gtgtaaggaa caagatgaca gcttgtatat agaagagcac atagaggagc gaatggcttt 893701 cctgtatgat cacattttga ttagtgatca ggaaattgcg aaaaagccgg ctggatttca 893761 tgaagggacc agtattattg actattctga agctgaagag gaaagagaag cgtttggcag 893821 ggcttttcaa tacgatcgtc tcggcgctgt ccaatatgcc gagaaatttt ggaacaagcg 893881 caatcctgct tataaaaatt tcagcgataa ctgtacaaat tttatttctc agtgtcttca 893941 tgcaggaggc gcgccgatgc gcggtcatcc gaacagggga tcaggctggt ggatgaaaca 894001 aagctcatgg agctacagct ggacggtggc tcactctatg aaaatgtatt tgtcgaattc 894061 aaaggccgga ctgcgtgcgg tgcgggtgaa atcagcggaa gaactgatgc cgggcgatgt 894121 gatttgctat gacttcgaag gagacggccg gtttaatcat acaacgattg tcgtggcaaa 894181 ggacaaaggc aatatgccgc ttgtcaacgc ccagacttat gacagcagga tgaggtattg 894241 gtcatatgag gattctacgg catacacgcc gtcaatacga tatgcctttt ttcatatcgt 894301 tgatgatacg acaaaagagt aattaatgtt ataatgatgg gcggataaga aaaacagagg 894361 tgaacattgt ggcattacat gtcgttttat atcaaccaga aattcccgct aacacaggga 894421 atattgcacg tacttgtgca gcaaccaata caacgctaca cctgattcgt ccgctcggct 894481 tttcaacgga tgataaaatg ctgaagcgtg ccggactcga ttattgggag tttgttaacg 894541 ttgtgtatca tgattcgtta gaagaattgt ttgaggcata taaaaaaggc aagtttttct 894601 ttattacaaa atttggccag cagcctcata catcatttga ttacactgat cttgacgagg 894661 attatttctt cgtgttcgga agagaaacaa gcggtttgcc aaaggattta attcaaaata 894721 atatggaccg ctgcctgcgt cttccgatga cagagcatgt cagatcgtta aatctgtcca 894781 atactgccgc gattcttgtt tatgaagcgc tgcgccagca aaattaccgt gatttaaaat 894841 agtgaaaaac ccgctcatcg atgatgggcg ggtttttttg cggatgttga aatgctttgt 894901 ttcgtttttg ggcttaacaa cgtaacagtg ttatgttaca atgtacccat caaaggagct 894961 ggacttatgg aagaacaatt aatctctaaa aaagaattac ttgaaagaac atcgatttca 895021 tacggtcagc tgtatcgatg gaagcggaaa aacttaatac ctgaggaatg gtttattcgt 895081 aaatccacat ttacagggca agagacgttt tttccgagag aggagatttt aaaacgtata 895141 tcaatgattc aaaagatgaa agaaaatttg tctttggatg aaatgaggga aatgctgtcg 895201 ccgaaaatga aggatgtcag catgaccgct gatgaattgc ttcataaagg tttggtttca 895261 aggcctgctc ttgaagccta ttcagaagac ggaggaagtc cggttttttc atccagcgat 895321 ttgctttcgc tgtttgtgct tgagggcctg ctgcagtctg gaaatgtcag ccttgcagaa 895381 gcaaaaatgg ctgcagaggt attaaagaag catgatactg aagagattga aaaacagacg 895441 gagctgattg tgctccgcaa gctcggtgtc acaacttgtt ttatagcggc tgcggcggac 895501 agcattttgt ttgaatcatc cgtaaaggtt gtggaacggg tagatttatt aaaagcttca 895561 gaggaattaa aaacaacatt tatgcaggag ggccatcaat ggatgtagtg gaaaagctgg 895621 tgataaatgg atcaggaagt tctaagggag gaacatttca atcagttgag attaatggca 895681 gcgggacagt ggccggggac gtggagtgtg acactttttc ttttaatgga aacggaaaag 895741 cggacggcag cgtcaaagcg aaagcggtaa ctatcagcgg ttcaggaaag atacatggag 895801 acgttgaagc agaatctatc cggatgaatg gcactggttt tattcaagga gaggtatctg 895861 caaaacaatt gaaaatcgct ggatcatcaa catttggcgg cactgtcaag gctgatggaa 895921 ttgacattag cggaaaagct gtcatggaag cagattgtga aacagaaacc tttcaatcag 895981 aagggaaatg caaaatcagc gggcttttaa atgcagacca ggtgatcatt aagctttctg 896041 caggggaaag ctatgcgcgg gagatcggct gccgccatct tcaagtgacc tgcagaaaag 896101 gaatgctgac attgctcaga ttgatgccgc agcctgttct aacagcagag ctgatcgaag 896161 gtgacgtgat tgaattgaca aatacaaagg cgaaaaccgt gcgcggtaat aaagtgatca 896221 tcggcccgga ttgccagatt gaaaccgtcg aatacagcgg ggactatacc tgtgatccaa 896281 gcgcgtcggt tgaaacatcc acaaagttgt aaggaggatc gtaatggaga caacaaaact 896341 gggaaattta aaattatatg gcgctgggca tgccgcagga ggcgcgtatc acaatgtcag 896401 catcaaagga gaaggtatag ttggagaagg gctgtctgct gtaggctgcc gcatatacgg 896461 aacgggcctt tttctcggaa aagcagagac tgagcggctg cgtgtgctcg gagaaagtga 896521 atgtaaaggc gatctgacag ccggcaaaat caatatatat gggacaatga aagtcagcgg 896581 ctcacttcaa tttgatcgat tcaatctgaa aggccagact gaaattggcg ggaatatgac 896641 tggagaatcc tgcgatgtga aagggaagct tagcgtaata ggtgattgtg aaacagaaat 896701 gttccatgtc acaggctgtg ttgatgtatc ggggttatta aattcgggtg agatcaagct 896761 gggattgagc catgatataa gccatgtgca ggaaatcggc ggaacaacaa ttacagtgaa 896821 aagacgcgcg agttttttta gccggaagaa agggaagctg atcgccgatg tcatagaagg 896881 agatcgggtt tatttggaga ataccgaagc ggcagttgtc aggggaaaag aagtgatcat 896941 cgggccggga tgcagcatcg gaacgattga gtacgaatac aaatgtgaat gcgatccgca 897001 ttcacagatt aaagaaaaaa caaaactgta aaacattgtt ctgttataca aaaagggtgc 897061 tctttcagga gcaccctttt ttattctttt ccaggcttgc tttcgtatcc tgcggtaaaa 897121 attgatacta aaaaagtgac aatgacaccc atcatgatga ttgttttcac cgtctctccc 897181 cctcttcaat ttttccgtgc tgtccgagtc tggatgattc tgtatttttc tttattatga 897241 acggtcgcag tctgccttgt caacgatgta tgagtatctt tatttttaag aaaccaaagc 897301 atgtatcacg agatggcggc atagattgta tcaaagtacc ttatttgcat agtgtatcaa 897361 acatgataga ggaggtcctt atggatatat taaagaaaat tgaaaagtac agagaggaag 897421 agcagcggct gaaatgggaa ggaactttcg ccgattattt ggagattatt aaagaaaatc 897481 cgatggtcgc gcaatctgct cattctcgag tttttaatat gataaaagac agcgggatag 897541 aggagattga cggacgcaag aagtacagtt tttttgaccg cgagctgttc gggcttgaag 897601 aatctctgga gcgtcttgtg gaagagtatt ttcatccggc tgccaaacgt ctagatgtca 897661 gaaagcggat tctattgctg atggggcctg tgagcggcgg taaatccacg ctggtcacaa 897721 tgcttaaaaa aggtctcgaa gcgtacacgc tgacagataa tggcgctgta tatgcgatta 897781 aaggctgccc gatgcacgag gaccctctac atttaatccc ccatcattta cgcgatgact 897841 tttacagaga atacggcatt agaatagaag gaagtctttc tcctttaaat gtcatgaggc 897901 tggaggaaga gtacggagga agaattgagg atgtgaaggt ggagcgcatc ttcttttcag 897961 aagataagcg tacgggaatt ggaacattca gtccctctga tccgaaatct caggatattg 898021 ccgatttgac ggggagtatt gatttctcaa caatcgccga gtacggttca gaatcagatc 898081 cgcgcgctta tcgatttgac ggagagctga ataaagcgaa ccgcgggatg atggagtttc 898141 aggagatgct gaaatgtgat gagaaatttc tctggcattt gctttccttg acacaggaag 898201 ggaattttaa agctgggcgg tttgcgttaa tttctgctga tgagctgatc gtggctcaca 898261 cgaatgaaac ggagtatcgc tcatttattt ctaataagaa gaatgaagcc ctgcactcaa 898321 gaatcatcgt gatgccggtt ccttataatt taaaagtgtc tgaggaagag agaatttatg 898381 aaaaaatgat tgcagaaagc gatgtggcgg atgttcatat tgccccgcat acgttgaagg 898441 tcgccgcgat gttctcaatc cttacccggt taaaagagcc gaagcggtcg gatattgatc 898501 tggtcaagaa aatgagactg tatgatgggg aaagtgtgga aggatataac tctgtcgacg 898561 ttgaggatat gaaaaaagaa tataatgatg aaggcatgag cggaattgat ccgcggtacg 898621 tgatcaaccg gatttcttca acgattatca gaaaaaatat ggaatcgatt aattctctcg 898681 atgtccttcg ctccttaaaa gaaggtcttg atcagcaccc atcaatttca agcgaggaca 898741 gggagcggta tttgaatttt atctctgccg cccgcaagga atatgacgat attgcgaaaa 898801 aggaagttca aaaagcgttt gtttattcat atgaagaatc agcaaaaaca cttatggaca 898861 attacctcga taacgtagag gcctattgca ataaaaacaa gcttcgtgat cctttgacag 898921 gagaggaaat gaaccctgac gaaaagctga tgagatccat cgaagagcag atcggcattt 898981 cggaaaacgc caaaaaagcg ttccgcgaag aaattttaat ccgcatctcg gcctatgcga 899041 gaaaaggcaa gcggtttgat tacaattccc atgaaagact gcgtgaagct attcagaaaa 899101 agctgtttgc tgatctgaag gatgtcgtta aaattacgac ctcaacaaaa acgccggatg 899161 agcagcagct gaaaaaggta aatgaagtcg tggcccgttt aattgatgag cacggctaca 899221 actcgacgag cgccaatgag ctgctgaaat atgtcggcag cctgctgaac cgataagcaa 899281 cgtgacccgt ccgaataggg cgggttattt tgtcccattt tctaaatagt ttgtcaatta 899341 aacgtgcata tgtgcatatg atgaatataa atcttttcaa aagacttgtt tcataatctg 899401 gcacaagccg gaatacgtat gtatcacgac cacaaatggt taaggagggg aattcatgtc 899461 ccaaaatgac agcggccatt ttttgatttc tgaggaaaac tggtccctcc atcgcaaagg 899521 cttcgatgac cagcagcgcc accagaaaaa agtgcaggaa gcgatcaaaa acaatcttcc 899581 ggacctcgta actgaggaaa gcattattat gtctaatgga aaagatgtag tgaagatccc 899641 aatccgttca cttgatgagt ataaaatccg ttataactat gataaaaata aacatgtagg 899701 gcaaggagac ggcgagagcc aggttggaga tgttgtggcc cgggatggat cagacaaaaa 899761 acaagggcct ggaaaagggc agggtgccgg tgatcaggca ggcgaggatt attatgaagc 899821 ggaagtttca ttaatggatt tagaagaagc gctttttaaa gaattagagc ttccgaatct 899881 ccagcaaaaa gagcgggaca atatcattca tacagatatc gagtttaatg atatccgtaa 899941 aacagggtta accggtaata ttgataagaa aagaacgatg atgtcagcct ttaaacgaaa 900001 cgcaatgtca ggaaaaccgt cgttctaccc aatttatccg gaggacctga aatataagac 900061 gtggaatgac atcacaaagc ccgaatcaaa agccgtcgtt ttagccatga tggatacaag 900121 cggcagtatg ggggtttggg aaaaatacat ggccagaagc ttctttttct ggatgacccg 900181 ttttttgcgg acaaaatacg agactgtgga aattgaattt attgcccatc atacagaagc 900241 aagagtggtc tcggaggagg attttttctc aaagggagaa agcggcggaa caatttgttc 900301 ttccgtatat cggaagtcgc ttgagcttat tgatgaaaag tacaatcccg cccgctataa 900361 catttacccg tttcattttt ctgacggtga caacctgaca tctgataacg cgcgctgtgt 900421 gaagctggtc aatgatatta tgaagaaggc caatctgttt tgctacggcg aggtcaatca 900481 gtacaacagg cattcaacgt taatgtctgc atataaaaat gtaaaagatg agaaatttaa 900541 gtactatatt ttaaaacaga aatctgatgt ttttcaggct ctaaagaact ttttcagaaa 900601 tgaagagtct ggtgtaagcc atcaattttc gtaatgaaaa gcccatttca gggctttttt 900661 ttatttaata aaagcaagaa aacgcttgcg aaaaaaatac gggagaaaaa gaaatttttc 900721 ctttgacaaa tcttctttca tttattaata ttttatcttg tgaactatta ttgaggaatg 900781 aggtgaaaag gagttgactg aatcagaacg tgctttgctc acttttgaac agctcttcga 900841 tacgtctcgg gcgatatata aaaaacagaa gaagatattg gagattgtgc ttgagccttt 900901 tgatattaca gtccttcaat atttgctgat gtttaaaatt catcaaagcg gaagcacccc 900961 gctaagcaag ctggcaatgt cgcttgatct taagcctgct tctgtgacgc ggatgacaga 901021 tattctgtat aagcgccaat tgatgaatcg atatgacagt ccggatgacc gccgtatcgt 901081 catgattcag ttaaccgaag agggggaaga actgatagaa aaagccgctg tgcaatatgc 901141 aaaaatgggt gctggcttgt accaaaagct tgatacctcc cagctgcagt atttgcgcaa 901201 actagccgga agtttaacga agcttgctga aggctgttca gaaaaaagcg gtaattaaaa 901261 acttctcaca tattttcacc agctttccgc aaaatgatag aggatgaaac gaaaggagaa 901321 aacaaaatga acagaggacg tttaattctg accaacatta tcggtttgat tgttgttctt 901381 gcaattatag ctggaggtgc ttactactat tatcaaagca caaactacgt aaaaacagat 901441 gaagcaaaag tagcgggcga tatggctgct attactgctc cagcagcagg taaagtatct 901501 gactgggatc tggacgaagg aaaaacagtg aaaaaaggcg acacagttgc aaaaatcaaa 901561 ggtgaacaaa ctgttgacgt aaaatccatt atggatggca caattgtgaa aaacgaagtg 901621 aaaaacggac aaaccgtaca agctggtaca acaattgcac aaacgattga catggacaac 901681 ctatacatca cagcaaatat taaagaaaca gatattgcgg atattgaagt aggaaatagt 901741 gtagacgtag tagttgacgg agaccctgat actacatttg acggtactgt agaagaaatt 901801 ggttatgcga ctaactcaac ttttgatatg cttccttcta caaattcaag cggaaactac 901861 acaaaagtaa cacaaaaagt tcctgtgaaa atttcaatca aaaacccatc tgataaggtg 901921 cttcctggaa tgaatgcatc tgttaaaatt tctgagtaaa acagatcagt catcaaacca 901981 tgaaaggagg ttgtcttaga tggctacagg caaagaaaaa aatgcaaaaa accctatgtc 902041 attgctgatt gtgctaatgg cgggtttatt tttggcaatt ctaaaccaaa cactgcttaa 902101 tgttgcaatg ccgcacttaa tgactgaatt tggcgtaagt gcaacgacga ttcagtggct 902161 gacaacaggt tacatgcttg ttaacggtgt attgattccg ttatctgctt tcctgattac 902221 acgatttggc cagcggagtc tctttctcgt cgcgatgttt tgttttacgc tcggtacgtt 902281 agtctgcggt atcgcaccta acttctctac aatgctgatc ggccgtttga ttcaggccgt 902341 gggcggaggt atcttgcagc cgctcgttat gacaaccatt ctgttaattt tcccgcctga 902401 aagcaggggg aaaggaatgg ggattttcgg gctagcgatg atgtttgctc cagcggtcgg 902461 cccgactctt tccgggtgga ttattgagca ttatacatgg cgcattatgt tttacggact 902521 tgtgccgatc ggcgcaattg ttatcattgt ggctttcttc atctttaaaa atatggtgga 902581 gccgcaaaaa atcaaactcg atactcttgg cgcaatcctc tcgattgtcg gattcgcctc 902641 cttattatac ggagtcagtg aagccggatc tgacggctgg accgacccga ttgtattgtc 902701 tacagttatt atcggagcca ttgcaattgt tgcttttgtt gttcagcaat tgcgtcatga 902761 tgatccgatg cttgatttca gagtgtttaa atatgacatt ttctcactct cgagtgtcat 902821 taatatcatt attacagtgg cactttacac tggtatgttc cttttaccga tttatctgca 902881 aaacctggtc ggctttacgg cgcttcaatc cggtctgctt ctgcttccgg gtgcgatcgt 902941 tatgctgatt atgtcaccga tctcaggtat tttgttcgat aaattcggac cgagaccgct 903001 tgcgattatc gggcttctcg tgacagtggt aacaacgtat caatacacgc aattgacaat 903061 tgatacacca tatacacaca tcatgctgat ctattcaatt cgtgcatttg gtatgtctct 903121 cttaatgatg ccagtcatga cagccgggat gaaccagctt cctgcccgtc tgaacagcca 903181 cggaacggcg atgagtaaca cgcttcgcca aatcagcgga tcaatcggaa caagtttaat 903241 tacgacgatt tatacaaacc ggacgacatt ccattattca caaattgcag ataaaacaag 903301 cacggcggac ccgaacttcc tccatgcgtt ccaaaatgca gtttcgaatt taatggtgaa 903361 tatgaatgtg tcttatgata cggcgaaaac atatgtgtac tcacatattt ataaacacgc 903421 atcactcgat tccaatgtca tggggataaa tgatgccttt atgtgggcaa ccttattctg 903481 tgtagcaggt ttgattttaa gtatcttcct gcgtgacgtc agaaaagata aattgcgtaa 903541 gaagaaaaaa gaggagcttt cattacttcc tgctccaaaa gaagctaagg aatcttaatc 903601 tgtacaggga ggtttcctga atgaaaattt atgtagtgta tgatagtgaa ggcgaacata 903661 ctaaagtgct tgcagaagcg attgctgaag gcgcgagaga aaacgacgcg gctgaagtgt 903721 tcatcgacca tgtagatcag gctgatatcc gcaagcttaa agatatggat gcgattattt 903781 ggggatgccc agggcatttc ggaacaatca gctccggtct taaaacttgg atcgacagac 903841 ttggctactt gtgggctgaa ggcgagctga tcaacaaagt cggtgctgtc ttctgcacaa 903901 cggcaacaac acacggcggc ttggaaatga caatgcacaa tttaatcacg ccgatgttcc 903961 accaaggcat gattgttgtc ggactgcctg gcaacgtgcc tgaaaacgca ctttatggct 904021 cttattacgg agcaggtgtc acttgtccgg tagacagtga tgagttaatg tctgaggaag 904081 gtattcagct tggacgcgcg ttgggaagac gtgtcagcca agtcacagga aacctaacag 904141 caggacagta aggagaggtt gaaatggcca ttattatagc aataattgct gctgtcattg 904201 tcattgcggc ccttattaca tttaacgtcc gcaacgcctc acctggacct gagaagcaag 904261 aagcaaccga tagaatcgca cctccagaag aggaaaaaaa cgaagcgcat taccctgctg 904321 aagcaagggc tgccgagcat acgccatccg ttgtcaaaaa cgattctcca aaagagaagc 904381 gtgacacaat gggtgatgat atttacaggc aggcgctgca aaagtttaag cattctgatg 904441 aagttcatgc agaagaagag gtcactgagg aaagtgacaa aatgcaggac cgcagctatc 904501 gtgatgcgct gctctctatg aaaaataaga aaaagtaatg aaaaaggcaa atccgtttac 904561 tcatgcgggt ttgccttttt tgctgtttcc atcaattatg tttttatcaa ataaatccat 904621 ggaatatgtt gtattccacc ttgatctagt gtactatgtt actcatacac cgaggatttt 904681 ttccgggagg taaagacatg aattcttttt taggtttatt aaagaaagat atcaagcttt 904741 caagaatgtg gctgctagta tggatatgcg gaatcatttt cttattggga acaggccata 904801 ttatagcttc tcgcacgaaa gaacctctag tcatttttgg tttttttgtt gcagttgctt 904861 tttttctgct tttcttatct cctgtttttg ttttttatca ccttcgcaag gaagggaaat 904921 cacagctttg gctgtacaat ccaaatggcg gcttatggct gttttcttct aaattggcag 904981 catctttgct ctatcaattt gtgattcagt tggcattaac agcctatggc atatggatgt 905041 atcatatgct ctctgtaaaa aatctgctgg agcatcaagt tgatataacg agtacagtgg 905101 ctttgctgaa tatgtatggg cttatttctt cgttagatat gtcagtaaca gtcattgtgt 905161 tttggactgt ttttcactct ctcagaaatt ggcgcggaat gcggtgggct gcgatggttc 905221 tgttggtcgc aatgtggtta ttcttcgatg aatacatcat aagccctttg gttgaatctc 905281 aaaagcattt ctggcctgta acagtctatt gcaattttga tttccacttc cacaatgttt 905341 ggagattgga actaaaacct atccatctgt ctgtgctagg gtttcctatt gctatagtca 905401 tcacattctt gctgctcatc atggcttcaa aactgcttga tcgtaaagta gaggtgtaaa 905461 tatggacaat caattccaat cctcgaaacc gatttatctg cagatcgctg atcagatctt 905521 ttataggctg gtcaggaagg agctgctccc aggagacaag cttccttcag taagagaaat 905581 ggcgattcaa actaaagtaa atcccaatac aattcaaaga acttacagtg agatggaaag 905641 gctgggtatt gtggagacaa gaagaggtca agggacgttt attgcggaaa aagcagaaat 905701 cgtagacgag ctgaaagaca agctgacacg agaggtgctg gaaggctttg tcaagcaaat 905761 gaaagagctg gggctaacga aagaagaaat gttagaaggg attaaaacat tcacagaggg 905821 aggctaaaat ggaaatcaag ctagaacatg tatcaaaaaa atacggccgc catacggccg 905881 tcaatgatgt gtcaatcacc ctatcatccg gacggattta tggcctgatt ggaccgaacg 905941 gcagcggcaa gtcaacgacc ctgaaaatga tggctggcct tctgtttccg acttcaggat 906001 ttgtaaaagt tgatgaagag caggttacga gagaaatggt gcgtcaaacg gcttatctta 906061 ctgagcttga tatgttttat ccgcatttca ctgttaaaga tatggtgaat ttttatcagt 906121 cgcagtttcc tgattttcat acagaacagg tttataagct attgaatgag atgcagctga 906181 atccggaaaa aaagatcaaa aagctatcaa aaggaaatcg gggcaggctg aaaatcgttc 906241 ttgctttagc gagacgggca gacgtcatct tgcttgatga acctttttcc gggcttgatc 906301 cgatggtcag ggattccatc gtaaacagcc ttgtgtcgta cattgatttt gagcagcaga 906361 ttgtcgtgat cgcgacacat gaaattgatg aaattgagac tttgttagat gaagtaatca 906421 tcctcgccaa tggagaaaaa gttgcgcagc gtgaagtaga agatattcgt gaacaggaag 906481 gcatgtctgt tttgcaatgg tttaaatcaa aaatggaagt ttgctagaaa gaggaggaat 906541 atgatgaaaa cagtgttgga attgaaaaac gtgactaaaa acatcagagg ccgaacgatc 906601 attgatgatc tcagttttac gattcgtgaa ggcgaggtat tcggtttttt aggaccaaac 906661 ggagcgggga aaacgacaac catccggatg atggtggggt taatgaagct gtcgaaaggt 906721 gatgtcctca tttgcggcca atcaattacg aaagaatatg ccaaggcgat taagcatatc 906781 ggagcgatcg ttgagaatcc cgagctgtat aaatttttga gcggatataa aaatctccag 906841 caattcgcaa ggatggtcaa gggtgtcacg aaggaaaaaa ttgatgaagt tgttgaactg 906901 gtcggtttaa cagacagaat ccacgacaag gtgaaaacat attctctggg gatgagacag 906961 cgtcttggct tggcacaatg ccttctgcac gatccgaaag tgctgatttt ggatgaaccg 907021 acaaacggcc ttgatccggc ggggatcaga gaaatcagag atcatttaaa gaagctgacc 907081 cgagaaagag gaatggctgt catcgtttca agccacctgc tgtcagaaat ggaactgatg 907141 tgtgatcgaa ttgcgattct gcaaaaagga aagctgatcg atattcaaaa tgtaaaagat 907201 gaaaacattg atgagaatga tacatatttc ttccaggttg agcagccgag tgaagccgct 907261 actgttttaa atcagtacga tttgctgagt aagacaaatg gtgtagaaat caaactggct 907321 aaagaggaag tccctgcggt tattgaattg ctggtgatgc agcaaatccg tatttatgag 907381 gtcaaggtca taacaaaatc attagaggac cgtttcttag aaatgacagg tgaaacaaaa 907441 gaggaggttc agcatgctta atttgattta taatgagtgg ctcaaaattt tcagccgtgc 907501 cggaacatgg gtgatgatcg gaattctggg gctgacaatg gttggatttg catttttggc 907561 gaatcatttt tctgccggtg aatcaaattc ccattggaaa caagagcttc aagcacaaaa 907621 cgccgaatta aagaaagaaa tcaaagaaga tccttcactg aaagatgggt ataaagaaac 907681 aatcacactc aatgactatc gcatcgagca taatatccct agtgacacgg gctatacggt 907741 atggtcttat gtaacggatt cagcaaactt taccatcctt accggtctgt ttactattat 907801 catcgcggcc ggaattgtcg cgaacgaatt taattgggga acgattaagc tattaatgat 907861 tcggccgctc agtcgttttc aaattttgat gtccaaatat attacagttc tcctgtttgg 907921 gctcctgttg ctgttgattt tatttatcgg ttctacttta ttagggttga tcttcttcgg 907981 aacgggtggt gaaaccgccg cgaatattca tttaatctat aaggatggcc atgtcattga 908041 gcaaaacatg atggggcatt tggctacaac gtatctttct gaatccgtct cggctttaat 908101 ggtggcgacg atggcgttta tgctgtctgc ggtattcaga aacagctctc ttgcggttgg 908161 tttttccatc ttcttgttgg ttgccggtac gactgcaact gcatttattg cagcgaaatt 908221 tgactgggca aagtatatat tgtttgctaa tgtcgacttg actcagtatg tggatggcac 908281 accgttaata aaagggatga ctatgacgtt ttctctcgtc atgctggcga tctactttat 908341 catcttcctg ttgcttgctt tcggaatctt catgaagcgg gatattgcaa actaataaaa 908401 aaagctgttt tgcttatgca aaacagcttt tttgtcaaaa taaaaactgc aggtttgcac 908461 ctgcagtttt tcatatcaat ttatgcttac gcttctttag taacgttagc agcttgtggt 908521 ccgcggtttc cttcaacgat ttcaaaagaa acagcttggc cttcttctaa agttttgaag 908581 ccttcgcctt gaatagcaga gaaatgaacg aatacatcgt cttgaccttc tacttcgatg 908641 aatccgaaac ctttttcaga gttgaaccat tttactttac cttctaacat gaaatttcct 908701 cctaaagcga tcataacgct taaattcact attcttgctc ttaacaaact ttcaagacga 908761 aaactcttac aaaactttct tcttaaagat agttcgaaca aaaataatta cctttactct 908821 accagtaatc ttcagaaaaa acaactgctt attgaaattt ttttcggaaa ataccatatt 908881 tatttttcaa tttgatattt atttacggaa attcatctgt tttctcgata tgtgatcata 908941 cgtttgcctt agtattcctt cattttggga agataagtaa taggaattga caaccttatt 909001 ggatatgagt aaggtaaaag ttaatcaata ttacaaatga caacgtttat caactaagag 909061 agcgtatgat ttttatgtct gatattgctt gcatgctcta atacatagat aggagtatgg 909121 tcacaatgaa aaagtggctt atatgcagtt tcgtccttgt tcttctcgtt tcatttactg 909181 catgttcacc gtctgcagaa catgaatcga taaaaatcgg gattgctgag tctgacgggg 909241 caatatggaa ctatattgct caaaaggctg aagaggcagg gctggatatt cagctgatcc 909301 ctttttctga ttatgcggag tctgatatcg cacttgctaa caaagaaatt gatgccaacg 909361 cctttcaaac catttcatat tttcagtcgt tcactgaaaa atacaaactt aatttggcac 909421 cgctcgggac gacatacata acgcccatgg gcatttattc aaaacgatat gaacgaatcc 909481 gagatatatc gcggggagct gtcgtttctg ttccggataa agcgttcgat tttggcaggg 909541 cgcttacggt gctccaggaa gcgggtttgc taacgctgaa aaacggattt aacggaacag 909601 gttcagttga tatgattaaa gataatccga gacacctgaa attaaaagct gtccggcaac 909661 aggatgcagt gagcggtgcc gacgtgtttg tcatgaaacc atcagaagca aaaaaagcgg 909721 gcttgaaccc gaaaaagcat acgctaaaga gcggcggact catgtctgag gaagagatga 909781 atttgattgt tgtcagagcg gaggatcaag atcgggaagc gctgcaaacc attcttgagc 909841 tttatcaagc tgatgataca gcggcattta tagaaaaaga atatcaggga gatcttgtcc 909901 cggcttttct gcctttgaaa cgtctttcag attggaagaa tgaattcgaa cattgaattc 909961 attctttttt ttctgaaaaa cacactctgt tccgtcccgt ttctttcgct ttgtaaagca 910021 tttgatcggc aagaatgggc aaggatcctg gctgttccgt attattgggg taatgagcgg 910081 cccctagtga tatcgtaact gaaagctcgt cgccgtttgt taatacaatc ggtgcatcac 910141 ttacagtgct cctgatccgt tcagcgatcc gggctgcttt atcaagagaa cagttcggca 910201 ggagcacggc aaattcttca ccgccgatcc gagcggcagg atcagtattt cggatggtct 910261 gcttcagacg taaccctagc tctttgagca cctgatctcc ttcatgatgg ccatattggt 910321 cattgatggt cttaaaatga tcgatatcca tataaatcag tgcaaattga aaatgcgggg 910381 tatcggccgc ctgctgatac agagcttttg tggtttcttc aaattttctt cggttataca 910441 cgcctgttaa aaagtcaaag tgcgcctgaa acttatattg tttaaaaaga agatgtgcat 910501 ttgtttcatg atcaataata tataaactga gcatgccgcc cgctattgat atgatccaaa 910561 aatacaaatg aagttcgtat gaatgtaaat ctataagaaa ataaaaggaa aaggagatca 910621 agctatttgt gattattaaa agatagaaag catgttttag ttgaactttt tttcttctag 910681 aaacaatgag tgacggaatg gcagcgatac aaatgataat aaccgagtat agtgcagatg 910741 tgttcatcgt aatcagcaag cggcctgcag tgatcatggc cagggccgtt gccgttgaaa 910801 cccagcctcc ataaagagcg gcaatcataa tagggatatt tcgaagatca ataattgaat 910861 gctgataggt aaatccaaaa accatcagaa taaccccgag caaaccgcag gccagtcctt 910921 taacagcttg aaaggatatg ctgtcttttt tatgtactag cctttcttta aacaggtggg 910981 tgaagagata attaaatgtg attaaaatgg tcaaatttac aaacagttct ttcagcaaat 911041 attatcaccc ttatataagg tactaaagat ggaagggaaa gaaaagaaca aaaaaggcat 911101 tatataaggt ttttttactt gaattgataa gttaaaataa ttcgcacttg acccatcgga 911161 attagtgtaa tatagtaaat gagaaaattt gaagggagag tttacctgct ttggagactt 911221 tactggttgt attacatgta tttattttat ttttacttat cttagggctc tttgttatgc 911281 agaaaaaaca tgtttccttc tctaaacgtg tatttactgc gctggggctg gggattgtat 911341 tcggatttgc gcttcagctg atttacggcc cgacttcaaa tatagtcatt caaacagccg 911401 actggtttaa tattgccggg ggcggatatg tcaaattgct tcagatggtt gtcatgccgc 911461 tcgtctttat ttcgattctc ggcgccttta caaagctgaa gctgacaaaa aatcttggga 911521 aaatcagcgg tttgattatc gggattttag tagcaacaac agcagttgct gcagctgtcg 911581 gtatcgcgtc cgcgctttca tttgatctgc aggcgattca ggttgaccaa ggaagtacag 911641 agctttcacg gggacaggag cttcagcaga aatcagagga tatgacagcg aaaacgctgc 911701 cgcagcagat tgttgaactg ctgcctggaa acccgttttt agattttacg ggagctagac 911761 cgacttcaac gatcgctgtc gttatttttg ccgctttcct tggagtggca ttcctcggcg 911821 taaaacacaa acagccggaa caggcagaaa catttaaaaa actggttgat gccgtttatg 911881 ccattgtcat gcgtgttgtc acactcattt tgagactgac gccttatggg gtgctggcca 911941 tcatgacaaa aacaattgca acgagtgatc ttgacagcat tctaaaactg ggcatgttcg 912001 tgattgcatc atatgccgcg ttaatcacta tgtttatcat tcatttgctg ctgctgacgt 912061 tcagcggctt gaatccggtg atttatttga aaaaagcggt gcctgtactt gtatttgcat 912121 ttacgtcaag gtctagcgca ggtgctttac cgctgaatat taaaacacag agaagcatgg 912181 gtgtaccgga gggaatcgca aactttgccg gttcgttcgg tctttcgatc ggccaaaatg 912241 gatgtgccgg catttatcct gcgatgctgg cgatgatgat tgctccgact gtcggccaaa 912301 atccatttga cccggtgttt attatcactg ttatcgcagt cgttgccatc agctccttcg 912361 gggttgccgg agtcggcggc ggagcgacat tcgcggcgct tcttgtttta tcatcattaa 912421 acatgcctgt cgcgctcgcc ggtttgttaa tctcaattga accgttaatc gacatggggc 912481 gtactgcttt gaatgtcagc ggaagcatga catccggtct tattacaagt aaggtcacaa 912541 aagaaattga tcaaggggca tttcatgatc aatccagagt gattgaagct gaagaagcgt 912601 aacatatgaa aacgtgtaat ccaagaggat tacacgtttt tttaacggcc aggctctaag 912661 tcctccagca tttccatcat cgtgttgtcg tccatgacat tcattgcgtt ttgttcaaaa 912721 tgaatgggtt cagcataatg cggctgtctt tttttcgcgg ctgtctcagt ttgcctagtt 912781 tgagactgtg tatgctgatg ctgtggttgc tgctgtccag cgtgctggtg ctgacggcca 912841 ttttgccgct ggctttgatg ctgcgaacgg tcctggttat caccgctgct tccgctgctt 912901 ccgctaaatg cttgtttgac catgtttcct acattagaag catcaaacgt gttattttct 912961 gaatttcgtc tgttcatttg tcctgtgata aacccgctga ttctttggcg gatctgaggt 913021 gataatgcag taataagcat agttgatcct atgatcaatg ctgcggggct gattcctctt 913081 cgctggttga acaacatgat ccctcctttg cagtgtattc atattttccc cctcgttaga 913141 caaattaacc gttatatttc ccgggaaagc atttcctcca gatttgcatg cataattaaa 913201 gccagttaga aaaacctata agtaaagtga taaaggagga attcacatgt ttggaaaaaa 913261 acaagtcctt gcgtctgtgc ttcttatccc tttgcttatg actggctgcg gtgtagccga 913321 ccaaggtgag ggcagacgtg ataataatga tgtaagaaac gtaaattatc gaaatccggc 913381 caatgacgat atgcggaatg taaacaatcg ggataacgtt gacaacaatg ttaatgataa 913441 tgtcaataac aatcgtgtaa atgacgataa taacaacgac cgaaaacttg aggttgctga 913501 tgaagcagct gataaagtaa cagacctaaa agaagtaaag catgccgata tcattgtggc 913561 tggaaatcaa gcctacgttg cagtcgtttt aaccaatgga aataaaggtg cagtagaaaa 913621 caatctgaag aaaaaaatag ccaaaaaggt aagatctact gacaaaaaca ttgataatgt 913681 ttacgtttca gctaaccctg attttgtaga gcgtatgcaa ggatatggaa agcgtattca 913741 aaatggtgac ccaatcgccg gattatttga tgaatttaca caaactgtac agcgtgtatt 913801 ccctaacgct gaataaatga aagaagccgc acaatttgtg cggctttttc tttgcgttaa 913861 tgacacactg cgaactcagg ctgcatagag taaaaataaa aaggtacaag acggaccggc 913921 tcagggaggg agacgtttgc gggatggcat aggaaagcgt gcggcatccg ctctattcct 913981 gtgcggagtc cttgtgatgc tggctgtaag ctcagccatc gtatcaagcg cgatgtatat 914041 cctgtctttt ccaggtcagg catctggaat aacaaaagaa caagtgacga agcacatgaa 914101 gaaagagtca ttcaaacagg ccgatattta ttacacttct aaggaaaagt ccttactgcc 914161 attgacgaaa gaaacgcttg aatatgcggt cagtattaat cagattatga ttggatattc 914221 gaatcaaaag cctattgaca ttattttttt tcctaatgaa aaacagatgg aggcttactc 914281 cggtttattg gatgtagttg gtttttattc tgaacgggag cagctgatcg gattgttgcc 914341 tgaagagaaa aagaaactgt tagaagggga cgaggtagcg gtttatttgt accagagatt 914401 gttgattcat gaatactcgc accatgcgtt tcaccagaaa ttgaaggagc ttgagacgga 914461 tcccgatgag tttccgttat ggtttcatga agggttaagc gagtggattg cgaactatga 914521 attgctcata gatccgatca cgttttctgt cgtgcccttt gaccgtttgc agactgatcg 914581 agactggcag gaagctagag ccgaatatga cactgatgtc tatttgcaaa gcttttatat 914641 gatcgatgag ctgacggaca aatacgggaa agacattatt tcagaaatga ttaaggaaac 914701 ggcaaaaaaa ggggactttg aaaaagggtt taaatcagca acaaaggaaa gtcttgatca 914761 atttgaaaaa gattttaaga aaaaatttga aaaaaacagt gcggcattgg atagtatcta 914821 tccaatgcct ttgttattag tgaagtcctt gctgacccat tccgccttgt gtcggaggca 914881 tttgtccttg ggcaggggcg aatgaatttc gcagctgttc catatcctgc gcatcaagct 914941 gaggaacctg gtaatagccg tgtttgtttt ggtataggaa aatttcaaat gccatttcaa 915001 catactcctg aatttgcgca gacagtacgc gtcttacggc cggatttgtc atttccagag 915061 aagccatcgt cagcatagaa gcttgtgctt taatcgcgca aagcatttgt cggctgatga 915121 tgctgtcatc aatatcattc atggattgaa caggtttttt aggctgtgac ggctgcatgc 915181 cgtaaacagt ctggttgtct tccttcatca tataagttgc tgttttttgt gaaggttcgc 915241 ttcctgtttt gaagcattct gcagttatat tgtattgaga tgtgatgaat tgatgttgac 915301 gatcaaggat gtttagtaat tcttgatcct tacagaattg tctcagcatc ataaactgat 915361 caagcacagt aagtgttccg gaaagcacct catgcatatc aaacatttca tgtccgccgt 915421 ggtttttatg cggtttgcca ggaatacctt tgttcatttg ggattgctgc tgctgattga 915481 actgatccaa accgaattcc tccttttttt tcagatcagc tgtattttgt gtcagtctgc 915541 cgtgtattat gcagaagcct gaaaggaatt atatgctgtc tgtcgaaatg ataagcagac 915601 aaaatcgttg tcattatgtg tataagggag gaaatatgat gaggcgtatt ctgcatattg 915661 tgttgatcac ggcattaatg ttcttaaatg taatgtacac gttcgaagct gtaaaggcag 915721 ctgaaccgca acagcctata tcgattgaga aggcaataca gcaaaaagaa ggacaggcac 915781 ttgtcgaagg atatgcagtc ggccaggctg tttccccgca gcattataaa ctgacaagcc 915841 ctttttcaaa tgattataat gttgcgctgg cagaccgtaa aaacaaaaca tcgcccgaac 915901 acatccttcc tgtgcaaatc ccctccgcct tcagaagcca atttgggctg caaaccaatc 915961 cgcttcttct tgggaaaaag ataacggttc aaggaaagct tgaaaattac tttaacacga 916021 caggacttaa aaacgttcag tcgatgaacg taaccgatga cacaaaaact ccgccggctg 916081 aacagcaagt gaccataaat gaagcacggg gaaggctgaa tgaagaagta acgataaaag 916141 ggatcattac agctgatcaa aacgcaatcg gaggcgggaa gctgtcgacc tttttgcaag 916201 atgaaaccgg aggcattaac atttattcgc catcccctga acaatttccc gaattaaaag 916261 agggtatgga tgtcacggtg acagggaaaa tcacgtctta ccaggggctg aaagaaatcg 916321 ttccaaactc atcaggcatc aaaatcaacc agtcaaatca atccctcccc gcccccaaac 916381 acttaacaat caatgaactt attaacggca gcctaggtga tcagtatgaa ggacgccttg 916441 tgaaactaac cgcttttgtt tcctcaattc caagttctcc tgccggcggc ggttacaatg 916501 taacaatgat tgatgacgac catcatgcaa tgacgctccg ggttatgaat gaaacagggg 916561 tgataaacga gcttgatgag ggcaaatggt atgaatttac cggtgtgtta agcagatacc 916621 aaacctttca gctgcttccg cgaaaatcgg ctgacctgaa gctgcttgaa gagcagcccg 916681 cacctccgtc tgcagaggga gaatatgaag ggattgttga ccgggtagtt gacggcgata 916741 ccattcatct taaatctccg gtgcttggaa cgacaaaaat ccggtttgta aatgtagatg 916801 cacccgaaac atatcacaca ccaaaaaatg acgcagatga aaatcaatta agatttggca 916861 aaaaagcatc tgactatcta aaaacggttc tgtccccggg tgataaaatt actgtcaagg 916921 tcgggagtga agccaaggac agctatggca gattgctcgg acaagtcata accgaatcag 916981 gttcaaacgt gaacttagag cttgtaaaaa acggctatgc tccgacgtat tttatttggc 917041 cggttgacaa tgaagaggat tatcagcaat ttcaggccgc agtagccgct gcaaaaaaag 917101 atcaaaaagg aatttggaat gaaaacgatc ccctcatgga aatgccgttt gaattcagag 917161 ccagagagca agggaaaggc ctgacaagat atgtggggga ctcgtcgaat aaaacatatg 917221 tgcagccagc tgactggaag aagatagctg tggaaaacag aattttcttc gcctcagcaa 917281 gtgaagcgga gagcgcggga tataaaaaaa ggcaaacggc acctcaagaa catgtgccgc 917341 ttagaattct cagcatgaat gatttgcatg gcaaaatcga tcagcaatat gagcttgatc 917401 ttgatggaaa tggaactgta gacggcacgt ttggacgcat ggattatgcc gccgcatatt 917461 taaaagaaaa aaaggctgaa aagaaaaact cgctgattgt gcacgcggga gatatgatcg 917521 gcggaagctc tccagtttcc tctcttcttc aggatgaacc gactgtagaa ctgatggagg 917581 acatcggatt tgatgtcgga accgtgggaa accacgaatt tgatgaaggc acggatgaac 917641 ttctgaggat cttaaatggc ggtgatcatc cgaaaggcac aagcggatat gatggacaga 917701 actttcccct tgtatgtgcc aattgtaaaa tgaaatcaac tggagagccc tttttgccgg 917761 cttacgacat cattaatgtg gagggcgtac ccgttgcttt tatcggagtt gtcacacagt 917821 cggcagctgg catggttatg cctgaaggaa taaaaaatat cgagtttaca gatgaagcaa 917881 cagcggtgaa taaggcggcc gaagagctca agaaaaaagg cgtgaaggcc atcgcggttc 917941 tcgcacatat gtcagctgaa caaaacggca acgccattac cggtgagtct gctgatcttg 918001 caaacaaaac agattctgaa attgacgtga tttttgccgc gcataatcat caggttgtta 918061 acggtgaagt gaatggaaaa ctgattgttc aagcgtttga atatggaaaa gcgataggtg 918121 tcgttgatgt agagatcgat aaaacgacaa aagacattgt caaaaagtcc gcggaaatcg 918181 tatatgttga tcaaagtaaa atcgaaccgg atgtcagcgc gtcagccatt ttaaagaaat 918241 acgaaacaat tgcggaaccg attatcagcg aggtagtcgg cgaagccgct gttgatatgg 918301 aaggggggta ttcaaatgac ggcgatacac ctcttggaaa cctgattgcg gatggtatga 918361 gagctgccat gaaaacggat tttgccctta tgaatggcgg cggcatacgt gaagcgctga 918421 agaagggtcc aattacgtgg ggagatcttt acaatattca gccgtttgga aatgtgttaa 918481 cgaagcttga gattaaagga aaagatttaa gagagattat caatgcgcaa atctcgccgg 918541 tttttgggcc tgactacagc atcagcgggt ttacgtatac gtgggataaa gaaaccggaa 918601 aagcagttga tatgaaaatg gcagatggca ccgagatcca gcccgatgcc acatatacat 918661 tgaccgtcaa caactttatg gcgacggcga caggagccaa atatcagcca atcggactgc 918721 tgggaaaaaa tccggtgaca gggcctgagg atttggaagc gacagttgag tacgtgaaga 918781 gttttgatga gccaattgcg tatacaaaag agggaagaat taagcttgct gaagccagtg 918841 atattgaaga ccctgtaaca gaagacccga taacggaaga gcctggagat gatccgggga 918901 cggaggatcc gattaaagag gatccaaggc caggtgaaga tttgcctgat ataaaagaaa 918961 ctccgggaac agcaccggtt catcagcttc cgccttcagc catttcgaga ttcaatgaaa 919021 taccaatcaa caacacaaaa accgctgata ctgctaatag catcagcaca ttgccgttac 919081 aaaccgagac tgcggaaagc gggtctgatc atcagcttcc ggatacgtca gcgggctact 919141 ataactttat ggtaatcggt gcggcggtga cattgtcagg aacttatcta tatgtcagaa 919201 gaaaaaggag cgcctccaga acgtgaaaaa agttattcca ctattcatca ttgctgccgg 919261 cctagtgatc gcaggctatg gaggctttaa attgatcgat acgaatacga aaacggaaca 919321 gacattaaaa gaagcaaagc tggcggctaa aaagccgcag gaagcttcgg ggacgaaaaa 919381 tagcacagat caagcaaaga acaaagcatc atttaagcct gagaccggcc aagcgagcgg 919441 cattttagaa ataccgaaaa tcaatgcaga gcttccgatc gtggagggca ccgatgctga 919501 tgatttagaa aaaggtgtcg ggcattacaa ggacagctat tatcctgatg aaaacggaca 919561 aattgtgctg tcagggcatc gggataccgt gtttcgccgg acgggagagc tggaaaaggg 919621 ggatcagctc cgtcttctcc tgtcatatgg agaattcaca tatgaaattg taaaaacaaa 919681 aattgtcgat aaggatgaca catctattat cacgctccag catgaaaagg aagagctgat 919741 tctgacgacc tgctatccgt tttcatacgt cggaaatgcc ccgaagcgct atattatata 919801 tggaaaacga gtgacttaaa aagccgaggc agtgcctgcg gcttttcttc atgaaaaata 919861 tgtgcggcaa aggtttttca tatcagcagg gaaaggggct tcagcaacta tgagctcgtc 919921 tgttatcggg tgaaccgctt gtactttatt ggcgtgcagt gcctgcctgt ttagcagctt 919981 gctcccgcct ccgtaaagcg agtctcctgt caacggatgg ccgaggctcg ccagatgaac 920041 acggatttgg tgtgttctgc ctgtttccag ctctaattca acgagcgaca gccgttcttt 920101 cgcattgctg gccattacct tgaaatgagt gacggctgtt tgcccgcctg gtgaaacccg 920161 gcgtcttgtc gggtgtgagc ggtctctgcc gatcggtgaa ttaattgtcc cttttttcgt 920221 ccgtagctta ccttcagcga tagcggtata cgtacgcttc agcgtctttt tctctaactg 920281 ctggtctaag atggcgtgtg ccaaacgatg cttggcaaaa acgatagcgc cagatgtatc 920341 ctgatcaaga cgatggacgt ggcgcacctt acatgtttcg ccatttatct gataatgata 920401 cgcgatcaaa ttagccagtg tgccggtttg cccatcctca ttcggatgcg tcgcgatgcc 920461 agcgggttta ttgatgatga gcatatgatt gtcctcaaat aaaatatcaa gctcgccata 920521 ctccggaatg accgaagatg cttcactttc ctgaagatca atgaacacgc ggtctccctt 920581 ttttacaatc atattgttta agacggattc gtgattgacc tttatctgtt gatgggacat 920641 ccagtcttgt atcactggtt tagaagcttt gagcgctgtt ttgagtacgg aaaacagcca 920701 ttggccgtcc tgtttttcat tgatgaggat ctcaagccct ctgccttttt ggttcatgtt 920761 aaatggctcc ttttcgaagc ggaaggctgc tgtttctcat aggaaacact taccttagct 920821 ttcgcgtttt tttctgtgct attcttgagt aagacttagg atattcgatg gcaagaaagg 920881 tgattgacgt gagaattgtg aacgcagcaa ctgcagaaca ggagagcttt atcaaggagc 920941 tgtctatgga gctgatccat gatgtatttc ctctttattt ctccgaactg gacattcagc 921001 gctttaaaaa gaaaggcgtt ctgtctttaa ataaccatta ttaccaagga acattaaaag 921061 aagcatttca aattatggct tgtctgcaaa tgatacatat tatcctgacc aagccttcgc 921121 cgcactctga tttgagtgat caggcgattt ttgaaaaaaa cagcaagatg ctgaatgatt 921181 ttgggattta ttttccgttt gctttttctg actttcaaaa gaagactaac aaagcctttt 921241 tcggtcaaag aaggctgata taatcatgcg gcaagggctt ttctattttt agaaaagctc 921301 tttttgtatc agagaaatca tatcataaaa cctttcctct aactcccttt ttaaacggct 921361 cgtgtctgaa catactaatg attgaaaggg gtgctgacaa tgagttcagt taaagataca 921421 atgacaacgc aggtggcaac cgtttctccg aatcaaacga ttcaggaagc ggcttctcta 921481 atgaaacagc ataacgtcgg ggcgatcccc gttgtagagc aaggtgtttt aaaaggaatg 921541 ctgactgacc gtgacattgc attaagaact acagctcagg gccgtgatgg ccagacaccc 921601 gtttcagaag tgatgtcaac agaactcgta tcaggaaacc ctaatatgag tctggaagac 921661 gcgtcgcagc tgatggccca gcaccaaatc cgccgccttc ctattgtaga tcaaaacaat 921721 ctagtcggga tcgttgcgct tggagacctg gcagtcaatc agatgtcgaa cgagtctgcg 921781 ggatcagcgc tgacaaacat ttctcaccaa aacattcatt aataagaaag agcttgcagt 921841 gtgcaggctc tttcttcaca taaaacctta ctttttgaaa gcagacttgt ttcggggtat 921901 agtgagtgta tacatatgtc tcaattcgta ctaaaggagt tgtacccagt gattaaagcg 921961 ttaatttttg attttgacgg gcttattcta gatacagaaa cacacgaata tgaggttctt 922021 caggaaatat ttgaagagca cggctcagtg ctgccgctat ctgtctgggg aaaggtcatc 922081 ggaactgctg cgggtttccg gccttttgaa tatttagaag agcagatcgg gaaaaagctg 922141 aaccatgaag agctcacaca attgagaaga gagcggtttg ccaaacgcat ggaatcagaa 922201 aaagcgagac ctggtgtcga agcgtatttg aatgcggcaa aggatttagg cttaaaaata 922261 ggccttgcct ccagctctga ttataaatgg gtgtccggcc atttgaagca aatcggcctg 922321 tttgatgatt ttgaagttat tcaaacggcg gatgatgtgg aagaggtgaa gccgaatcct 922381 gaactctatt tattggcggc aaagaacctg ggggtatcgc cagcggaatg tctcgcgttt 922441 gaggattctg tcaatggttc gattgctgcg aaacgtgcag gcatgaagtg tgtcattgtc 922501 ccgaataaag taacgggtac cttgatgttt gaagactatg atcacaggct tgaatcaatg 922561 gcggagatgg agctcgccct attgcttgat catctgaact cacaaaacta gaaaggagcg 922621 agtaggttgt ctgagaaatt agatttgacc cggtttgaaa agaaaatggt tatccgcaat 922681 atcgaagaga aagacatcga caagattatc gatcttcaaa aggactgctt tccaggaatg 922741 gagccttgga agcgggagca tttaatcagc catttggagc attttccgga aggacagttt 922801 tgtgcagaat tcgaaggtga aattatcggt tcgtgctcaa gtctcctgat taactttgat 922861 gaatatgatg accgccatac gtggcaggac attacagatg acggttatat caccaaccat 922921 aatcctgacg gcttgaatat gtacggaatt gaagtcatgg tgcacccgaa atacagacga 922981 atgaagatcg gccaccgttt gtacgaggcg agaaaggact tagccagacg cttaaacctg 923041 aaaagcatca tcataggcgg acggattcca aactatcaca aatatgcaga ggaaatgaca 923101 gcgagagagt atgttgaaca ggtgacacgc caccaaattt acgatccggt tctttctttt 923161 cagctgatga acggctttac ccttatgcga attaacccga actatctccc ggatgataca 923221 gcttcgatca agtatgcgac gctgatggaa tggaataatg tcgattatct accgcagcag 923281 acaaaacgct attataaatc ggcgttccct gttagaattt gtgtgatcca atacgaaatg 923341 aagaaaattt attcctttga ggaatttgcg aatcaagtag aatactatgt cgatgttgct 923401 tccgacgcaa gatctgattt tgcggtgttc ccggaaattt tcacaaccca gctgatgtcc 923461 ttccttgagg aacggtcacc gagcttggcg gtgcagagaa ttaccgagta tacagaagat 923521 tacatcagcc tgtttactga cttggctgtg aagtataacg tcaacattat cggcggatct 923581 catttcgtcg aagaggaagg caagatctat aatatcgctt acctgttcag acgggacgga 923641 acgatcgaga agcaatacaa actccatatt acgccgaatg aacgcaaatg gtgggggatc 923701 agcgcaggag accaagttcg cgtgtttgat acggactgcg ggaaaatcgc gatccagatc 923761 tgttatgaca ttgaatttcc tgagcttgcc cggattgcgg ctgataaagg agccaaaatc 923821 atctttacgc cattttgtac agaagaccgt caaggctatc tgcgtgtcag atactgttcg 923881 caggctagag cggttgaaaa tcaaatttat acggttatct ctggaacggt cggaaacctt 923941 ccgcaaacgg aaaacatgga tatccaatac gcccagtcag gcatctttgc cccgtctgat 924001 tttgaattcg cccgagacgg cattgtcggc gaaacaaacc cgaatattga aatggtcgtc 924061 atcggcgatg ttgacctgga aattctcaga agacagcgcc aaaacggtac agtgcgccag 924121 ctaaaagaca gacgacgtga tatttatcat attcaatata aaaaataatt cccaaaaaac 924181 ccgcctgaat tggcgggttt ttttaaacaa aagcggaatt gtttaggtgc tttctttaaa 924241 ataaaagtaa attgtatagt ggatgtgcct tatggagttt ctgtattttc gccatttcct 924301 atatcataca gaaaacggct aggcttcaca ttgctattgc aatggctgtc caagttgttt 924361 cgagtgcgac ctttatcagt acgatgctga gcattgtcac tttgcctgtt ttgctttgga 924421 agctgcatcc tctttcttct tgagaaaggg gatgttttat tatttacgcg gtttattgac 924481 tctgacccgg tctggcttta tattgaaggc agggaaatca tcaccaagac atcacataaa 924541 gagaaggtct gtttcaattg aattggcatt atagggaacg ctaatgaaat ggagatgatg 924601 gggatggaaa acattcagca aaatcaggga ttaaagcaaa aagatgagca atttgtgtgg 924661 catgccatga agggagcgca tcaagcggac agcctgatag cccagaaggc cgaaggggcc 924721 tgggtaaccg acacagacgg acgccgctat ttggatgcga tgtccggttt gtggtgcgtc 924781 aacattggtt acggcagaaa ggagcttgcg gaggctgcct atgagcaact aaaggagctg 924841 ccttactacc cgttaacgca aagtcacgca cccgcaattc aactggcgga aaagctgaat 924901 gaatggcttg gcggcgatta tgttattttt ttttccaaca gcggatcgga agcaaacgaa 924961 actgctttta aaattgcccg ccagtaccat ctgcaaaacg gcgaccacag ccgttataaa 925021 ttcatctcaa gatatcgggc ataccacggc aatacattgg gagcgctctc agctaccgga 925081 caggcgcagc ggaaatataa atacgagcct ttgagccaag ggttcctgca tgcagctccg 925141 ccagatatat accggaatcc tgatgatgca gacacgcttg aaagcgcaaa tgaaatcgac 925201 cgcatcatga catgggaatt aagcgaaacg attgccgggg tcattatgga gcccatcatt 925261 acaggcggag gcatcctaat gccgccggac ggatatatga agaaggtgga ggacatttgc 925321 cggcgccacg gagccctttt gatttgcgat gaagtgatct gcgggtttgg acggacaggt 925381 gagccgttcg ggtttatgca ctacggtgtg aagcctgata tcattacgat ggcaaaggga 925441 atcacaagcg cgtatctgcc attgtcagcg actgctgtga aacgggacat tttcgaagcg 925501 tatcaggggg aagctcctta tgaccgtttc cgccacgtga acacgttcgg cggaagcccg 925561 gctgcctgtg ctttggcgtt gaaaaacctg caaattatgg aggacgaaca gctgattcag 925621 cgatcccgtg atcttggagc aaagctttta ggtgagcttc aagctctgag agaacacccg 925681 gcagtcgggg atgttagagg aaaagggctg ctgatcggaa tcgaactcgt caaagacaaa 925741 ttgactaaag agccggctga tgccgccaaa gtaaaccaag tggttgcggc gtgcaaagaa 925801 aaagggctga tcatcggcaa aaacggcgat acagtcgccg gctacaacaa tgtcatccag 925861 cttgcgccgc cattttgcct gacagaagag gacctttcct ttatcgtgaa aacggtgaaa 925921 gaaagctttc aaacgatata atataaaagt gaattattaa aggagcacat gatgagtttt 925981 cacaaccagc cgatcttacc ggctattcgc aatatgaagc aatttgatga gtttttgaac 926041 agttcattct cttacggtgt tattcttgat attcatctcg gccagctgaa gggcgtgatc 926101 aaagaagcgc aaaagcacgg aaagaacatg atggtgcacg tcgatctcat tcaagggatt 926161 aagcatgacg aatacggtgc ggaatttata tgtcaggata tcaagcccgc tgggattatt 926221 tccacaagat cgaatgtgat tgccaaagcg aagcagaaga aaatttatgc cattcagcgc 926281 ctgtttttgc ttgatacaag cgcgatggag aaaagcatgg agtttatcgg caagcataag 926341 cctgacttca tcgaagtgct tcccggcatc gttccgtcac tcattcagga aataaaagag 926401 aaaacaggga ttcccatctt tgccgggggt ttcatccgta cggaagagga tgtagagcag 926461 gcattgaaag cgggggctgt agctgtcaca acatctaata ccaaattgtg gaaaaaatat 926521 gaaaactttt tgacggaaag tgattgacac cgctttcatg cactgataca attgcactag 926581 gttaatacat tgtgatggag aactcggaga ccacagcagc tctttacggc aaatgtttat 926641 gcacccgtaa agcggtttgt tgtggttttt ttattctctt cttctctatc atgcttttta 926701 atcgtgactt taggaggaat gtgctatgac agcattttgg ggagaagtca tcggtacgat 926761 gctgcttatc atttttggtg caggtgtttg tgcaggtgtc aatttaaaga aatcgctttc 926821 attccagtct ggctggattg ttgttgtatt tggatgggga ttgggtgttg ccatggcggc 926881 atacgcggtt ggcggcatca gcggtgccca tttgaatccg gcgctaacga tagcgcttgc 926941 atttgtagga gattttcctt ggaaagaggt tccggtttat attgcggcgc aaatgatcgg 927001 agcgatcatc ggtgcggtga ttatttatct gcattacctc ccgcactgga agtcaacgga 927061 tgatcccgct gccaagctgg gtgttttctc aacagggccc agcattccgc atacatttgc 927121 aaacgtttta agcgaagtga ttgggacatt tgtccttgta cttggaatct tggccatagg 927181 tgcaaatcaa tttacagaag gacttaatcc tttaatcgtc ggtttcctca ttgtagcaat 927241 cggtatttct ctgggaggca ccaccggcta tgctatcaat cctgcacgtg acttaggtcc 927301 gcggatcgcc cacgcttttc ttccgattcc ggggaagggc tcatcaaact ggaaatacgc 927361 atgggttccg gtagtcggcc cgattttagg cggatcattc ggcggtgtat tttacaacgc 927421 tgcatttaaa gggcacatca caagcagctt ctggattgta agcgttatat tggttgtggt 927481 attgttagga ctctatgttt atacgaaatc acattctgct aaaacattat caaattctaa 927541 atatatttaa tcaaagggga gacatcttat ggaaacgtac attttatcct tagatcaggg 927601 gacgacaagt tcaagagcga ttctgtttaa taaagaaggc aaaattgtcc actctgctca 927661 aaaggaattt acacaatact tcccgcatcc tggctgggtt gagcataatg ccaatgaaat 927721 ttggggctct gtcctcgcgg ttatcgcctc agtcatctct gaatcaggaa tcagcgcttc 927781 tcaaattgcc ggcatcggca tcacgaacca gcgcgagacg acggttgtgt gggataaaga 927841 tacaggaagt cctgtctata atgcaatcgt ttggcagtcc agacagacgt ccggcatttg 927901 tgaggaactt cgtgaaaaag gatataatga taaattcaga gaaaaaacag ggcttttaat 927961 cgatccttac ttctccggca cgaaggtgaa gtggatttta gacaatgtgg aaggcgcaag 928021 agaaaaagcg gaaaaaggcg agctgctgtt tggaacgatt gatacgtggc tcatttggaa 928081 aatgtcaggc ggaaaagcgc atgtgaccga ttactccaat gcctcaagaa cactgatgtt 928141 taatatttac gatttaaaat gggacgatga actgctcgac attctaggcg taccgaaatc 928201 catgctccct gaagtgaagc cgtcctctca tgtgtatgcg gagactgttg attatcactt 928261 cttcggaaaa aatatcccga ttgctggagc ggcaggcgac cagcagtccg cattgttcgg 928321 ccaggcatgc tttgaagaag gcatggggaa aaacacttac ggcacaggat gtttcatgct 928381 gatgaatacc ggggaaaaag caattaagtc cgaacatggg cttttgacaa caatcgcttg 928441 gggcattgac ggaaaagtga actatgcgtt agaagggagc atttttgtcg caggctctgc 928501 catccagtgg cttagagacg gtttgagaat gttccaggat tcatcgctaa gcgaatctta 928561 tgcagaaaaa gtggattcaa ctgacggcgt gtatgttgtt ccagcatttg tcggactggg 928621 aacgccttac tgggacagcg atgtgcgcgg ttcggttttc ggcctgacaa gagggacaac 928681 aaaagagcac tttatccgtg cgacactgga gtcattggct tatcagacca aagatgtgct 928741 tgacgcaatg gaagcagatt caaacatttc attaaagacg ctccgtgtag acggaggagc 928801 tgtaaaaaac aatttcctaa tgcagttcca aggagacctg ttgaatgttc ctgtggagcg 928861 cccggaaatt aatgaaacga ctgcacttgg cgcggcttat ttggcgggta tcgctgtggg 928921 attctggaag gaccgttctg aaatcgcgaa ccagtggaat ctggataaac ggtttgagcc 928981 tgaattggaa gaagaaaaac gaaatgagct gtataaaggc tggcaaaaag ccgtgaaagc 929041 agctatggct tttaaataaa gtaatactat ggtataatgg ttacaagtta ataagaacgg 929101 tcctgagatg aggagagacc acagcaccaa agtgtaagca tgcactttgg ctgttgtggt 929161 ctctttttct atttaccgtg acaacaagga ggaaacgtaa tgatgaatca tcaattttca 929221 agtcttgaaa gagatcgcat gctgacagac atgacgaaaa aaacatatga cctatttatt 929281 atcggaggag gaattacagg agccggaaca gctcttgacg cggcatcaag gggaatgaag 929341 gtcgcactaa gcgaaatgca ggactttgcg gcgggaacat caagccgatc aacgaagctg 929401 gtacatggcg gcttgcgcta tttaaaacaa tttgaagtga aaatggtcgc tgaggtagga 929461 aaagagcggg cgattgtgta tgaaaacggc ccgcatgtca ctacaccgga atggatgctg 929521 cttccgtttc ataaaggcgg cacattcggt tcatttacaa catctattgg gttaagggtt 929581 tatgacttcc ttgcaggtgt gaaaaagtca gaacgaagaa gcatgctttc agcaaaagaa 929641 acgctgcaaa aagagccttt ggtgaaaaaa gacggcttaa aaggcggcgg gtactatgtg 929701 gaataccgca ctgacgatgc gagactgacc atcgaagtca tgaaggaagc ggttaaattc 929761 ggggcagagc ctgtgaatta ctccaaagtg aaggagcttc tttacgaaaa aggcaaagcc 929821 gtcggcgtat taattgaaga tgtgctgaca aagaaagaat ataaagtgta tgcgaaaaaa 929881 attgtcaatg ctacaggccc ttgggtcgat cagctcagag aaaaagacca ttcgaaaaac 929941 ggaaagcatt tgcagcatac aaaaggcatt caccttgtat ttgaccagtc tgtctttccg 930001 ctgaaacagg ctgtatattt cgatacacct gatggccgga tggtatttgc gattcctcgt 930061 gaaggcaaaa catacgtggg aacaacagac actgtttaca aagaggcgct ggagcatccg 930121 cggatgacaa cggaggatcg tgattatgtc atcaaatcaa tcaattacat gttcccggaa 930181 ctgaatatca ctgcgaatga catcgaatcc agctgggcgg ggctgcgtcc gctgattcat 930241 gaagaaggca aagatccttc tgaaatttca cggaaagacg agatttggac atctgactca 930301 ggcctgatca ccattgccgg cggaaaactg actggataca gaaaaatggc ggagcacatc 930361 gttgatcttg tccgtgatcg cttaaaagaa gagggcgaaa aggattttgg accatgtaaa 930421 acgaaaaaca tgccaatctc tggcgggcac gtcggcggtt cgaaaaatct tatgtccttc 930481 gttaccgcga aaacaaaaga aggaattgca gccggtttat cagaaaaaga cgcaaaacag 930541 cttgcgatca gatacggctc taacgtagat cgcgtctttg accgggtaga agcgctgaaa 930601 gatgaggccg cgaaacgcaa cattccggtt catattcttg ctgaggcaga atacagtata 930661 gaagaagaga tgactgcaac ccctgctgac ttctttgtcc gcagaacggg acgtttattt 930721 tttgatatca attgggtaag aacatataaa gatgccgtta ttgattttat gagcgagcga 930781 ttccaatggg atgagcaggc gaaaaacaaa catacagaaa acctcaacaa gcttttacac 930841 gatgcggtcg taccgcttga gcaataaatc ataacgggct gtctgcagcc cgttatttct 930901 ttttacgtgc cgaaaggggg agatctcagg ttatcaagtg acagaggcac ccgcttcata 930961 taaaataatg gcataagctg atacatagga ggacgaatat gacttggaga aagagctatg 931021 aacgctggaa acagacagaa catttagatc tggaattaaa agagcgcctt attgaattag 931081 agggagatga acaggccctt gaggactgtt tctataaaga ccttgaattc ggtaccggcg 931141 gaatgcgcgg ggaaatcggc gccgggacaa atcggatgaa tatttacact gtgcgcaaag 931201 catcggccgg gtttgcggca tacatctcga agcaaggtga ggaagcgaaa aaacggggcg 931261 ttgtcattgc ttatgattcc cgccataagt ctccggagtt cgcgatggaa gcggcaaaaa 931321 cacttgcgac acaaggcatc caaacatacg tgtttgatga gcttcgcccg acgccagagc 931381 tgtcattcgc tgttagacag ctgaacgctt atggtggaat tgtggtaacg gcaagccata 931441 acccgcctga atataacggc tacaaagtat acggggatga tggcggccag ctgcctccaa 931501 aggaagcgga catcgtcatt gagcaggtaa acgcgattga aaatgagctg acgatcacag 931561 tggacgaaga aaataagtta aaagaaaaag gcttaatcaa aatcatcggt gaagatattg 931621 ataaagttta tacagaaaaa ctgacgtcca tttctgtaca tcctgaatta tcggaagaag 931681 tagatgtaaa ggttgttttc acaccgctgc atggaactgc aaataaaccg gtcagacgcg 931741 gtcttgaagc actcggctac aaaaatgtaa cggttgtcaa agaacaggaa ctgccggatt 931801 caaacttctc cactgttaca tcgccgaacc cggaagagca tgcggcattc gaatatgcca 931861 ttaagcttgg ggaggagcag aatgcagata ttctcatcgc gacagatcct gatgctgacc 931921 gcctcggcat cgcggtgaaa aacgatcaag gcaaatatac agtgctgaca ggaaaccaaa 931981 ccggagcgtt gctgcttcat tacctgcttt ctgaaaagaa aaaacaaggc atcctgcctg 932041 ataacggtgt tgttctcaaa acgatcgtca caagcgaaat cggccgtgct gtagcttctt 932101 cattcggcct tgatacgatt gatacgctga caggctttaa gtttatcggt gaaaagatta 932161 aggaatacga agcatcaggc cagtatacct tccaattcgg ttatgaagag agctacggtt 932221 atttaatcgg ggattttgcc cgcgataagg acgccattca ggctgcgctt ttggcagttg 932281 aagtttgcgc gttctataaa aaacagggaa tgtcattgta tgaggcgctc atcaatctct 932341 ttaacgaata tggtttttat cgtgaagggc tgaaatccct gacgctgaaa ggcaaacaag 932401 gagcagagca aattgaagcg attcttgctt ccttcagaca aaatccgccg cagaaaatgg 932461 cgggcaaaca ggttgtcaca gcagaagatt acgctgtaag caaacggacg cttctgactg 932521 aaagcaaaga agaagccatc gacttgccaa aatcaaatgt attgaaatac ttcctggaag 932581 acgggtcttg gttctgtctc cgtccttctg gaactgagcc gaaggttaaa ttttatttcg 932641 ccgtaaaagg gtcatctttg gaagacagtg aaaagcgact tgccgtcctt tctgaagatg 932701 taatgaagac ggtggatgaa attgttgagt caacagcaaa ataattcaag tatgagctgg 932761 gtcattgtaa atgatccggc tttttctttt tctcatccaa aagtctgaaa gaaaatcatc 932821 ctacaagtga agcaatgaaa tacaaaaaac tggtataatc ttaaatacaa gatcaatgcc 932881 ggagtgagaa acgtgagcaa aacgaggatg gaaaaattaa aaacgctgaa aacgattgcg 932941 gaaaccttaa atcaagggca cgatatcaaa gcaacactgg atgaggtttt aaaagagttg 933001 ctgagtctga caaaccttca atccggatgg atttttctga tcgaagaaga tgggtcttat 933061 acgttagcgg ccgacgctta tctgcccccg gctttaagcc gcaaggaaaa agtgctgatg 933121 tgcgaagggg agtgttactg cctgacgaaa ttcaataacg gagggcttag aaaagctgca 933181 aatatcatga actgcaaacg catcgaatca gcagaaaacc tgcattgttt tgacacagaa 933241 gggattacgc atcatgcaac tgtgccttta gaagacgggg acagaagatt cggattgtta 933301 aatgtagcgg cggccggaaa aaccatgttt gatgaggaag agctgcattt actcgagtct 933361 gtcgcctttc agatcggaac ggcaatccag cgtatgaggc tttctgaata tcaacaaaaa 933421 aatgctcttt taatggagcg taaccgcctc gctcaggagc ttcacgattc agtcaatcaa 933481 atgctgtttt ccgtcagttt aactgccaaa gctgcgaaga cactaacaaa agatgaaaat 933541 ttacagcaga tgattgattt catccaaaac ctatcacagg acgcgctcgc agaaatgaaa 933601 gcgttaattt ggcagcttcg ccccggagga ttggaaaaag ggctggctga agccattaaa 933661 agctatggtg cgctcattgg attgaagatc atttttacac aaaaaggctg tcctgttctg 933721 actgatgagc aggagcatat gctatggcgt gtcgtacagg aagctttaaa taactgcaaa 933781 aagcatgccg gaacggatac ggcgtatgtt agtctgactg cttctttgtg ccatgcggag 933841 ctggatatca tcgatcatgg ggcaggattt cgctatgaag cgcatgccgg tctgccttca 933901 cttggcataa aaggtatgaa agagcgagcg gaaaaagccg gagctaagtt ttggattgag 933961 tcagcgcttg gaactggaac aaagctgtcc atcaggcttc cgctaaaaag ccgaaaagga 934021 ggggcggtat gaaaattgtc attgctgatg atcatcatgt tgtcagaaag ggtctgcgtt 934081 ttttctttgc cacccaggat gatattgaag tcgtcggaga agctgcaact ggattagaag 934141 ccctccgtgt catcgaagag acaaagccgg atcttgtgct aatggatttg tctatgcccg 934201 agatggacgg cattcaagcc attaaaaaag caatacagca atttccggat acgaatatca 934261 ttgtgctgac gagctactct gatcaggagc acgtcatccc cgcgcttcag gcaggcgcga 934321 aggcgtatca attaaaggat acggagcccg aggaattggt gaaaacacga caagtgcatg 934381 gtggcgaata caagctttct acagctatta tgccccatgt gctgacacat atgaaaaatc 934441 agcacgaccc ggaaaaagaa aaatactatc aattaactag aagggaaaaa gacgttctga 934501 ctgaaatagc gaacgggaaa agcaataaag aaatcgcagc agccttgttt atttcagaaa 934561 aaacagtaaa aacccatgta tcgaatcttt tagcaaaact tgaagtggcc gatcgcacgc 934621 aagcagcgct tttcgcagtg aaatataacc tgaatggaga gatctcaaaa tgaacatgtt 934681 agtcataaat ggcacgccaa gaaaacatgg cagaacaaga attgcagcat cctatattgc 934741 agctctgtat cacacggatt tgattgatct aagcgagttt gtattgcccg tttttaacgg 934801 tgaagcggaa caatctgaac tgttgaaagt acaggagctt aagcaacgcg ttacgaaagc 934861 ggatgcgatt gtattattat cgcctgaata tcacagcggc atgagcggcg ctttaaaaaa 934921 tgccttggat tttctaagca gcgaacaatt caaatataag cccgttgcat tattggcagt 934981 agcgggaggc ggaaaaggcg gcatcaatgc gctgaacaat atgagaactg tgatgcgggg 935041 tgtctacgcc aatgtcattc cgaagcagct ggtgcttgat ccggtgcata ttgatgttga 935101 aaatgctaca gtggctgaaa acattaagga aagcataaaa gagcttgtcg aagaactcag 935161 catgttcgca aaagcaggaa atcccggcgt ctaaacgccg ggatttgttt atgtgagaag 935221 ggctatttga tcttcataag tcagctctgt ggcatgatca atatatcgga gaagggaata 935281 cagcatcttt tctaaaacgg cgtaatcctg ttcaaaatga tacgcatgca gaaaatgctc 935341 aattcgtttt gataacaaat cgtcctctgt acgcaccatt aaaattaata aattatccca 935401 ttgagaacga tgggtgtaat aaagcgcttt atcgtaatcg gcataatcca tgaatcgctt 935461 ctcctttctt gggtgagaag ttcatgatta gtttatgccg catcctctgt tattgacggg 935521 gcaaaacttg ccgtctgcgt cagtaaaggg gtagcaatat gagggagaca taaaatcaaa 935581 atgcctgaat gaagatatcg cttttggtaa acctatgagg gaatatattc tgggtacagg 935641 agactgaaaa aatgaaatcc ctgccgtata ccatcgcact tcttttttgc ggattgatta 935701 tcgtgtcaat ggctgcaaaa ggtcattcaa cggacacaga cgagtccgtt caaaagtggg 935761 aacagcttgc ctggagcaaa attcaggatg aatataaggg cgcttcattt tctgattatg 935821 cttatatggg gcgtacagag gtgaatgatc agcagactaa agatgtcttt cgggtgacag 935881 tcagacagaa agatgacact ttttctgttc gggccgaagt ctattttcat ccggtgacaa 935941 atcatatgat cagcatcaac gtctttaggc tctaataaaa aactgtacag ccgttaaggc 936001 cgcacagttt ctgtttttag aaatatcgtt ttgcaccgag atagcgctgt ttccagtaag 936061 agttgttcat attggaaatg acaactccgg aatcgttggc atttatgaat tccccgttgc 936121 ctaggtaaat tccgacgtgg gaagggccgg ctttatatgt tgaaaagaaa acgaaatctc 936181 cgacagcagg ctggctaact gatttcattg tgttccaata tcccgctgcc gttaatctag 936241 atacggatgt gactttgttc agtacatagt aaatgaatcc gctgcagtca aacccggacg 936301 gtgtcgtgcc tccccagcga tacggaaccc caagctgcgc tttagcggcc gaaatcattg 936361 tgttaatctt cgcactcgtt gagctggtgg tgtttgaaga accggatgaa gacgatgatg 936421 aagcttttcc ggaaatgacc agcttttggc caacctgcaa gacatccgtt tttaaattgt 936481 ttttctcacg aatctgctga gctgttacat taaatttttg agcaatcacc cataaggaat 936541 caccgctttt caccgtgtat gtagtcgtcg tgccggagct tgcatttgac gaagaagacg 936601 acgatgatga agagcctgaa gatgctttac ctgtcagctt caatacttgt ccaacgtaaa 936661 gcacatctga tttcagattg ttgatatttc ggatttgctg tacagtcagg ttatagttgt 936721 ttgcgatttt ccaaagtgaa tcaccgcttt taacggtata tttagttgtt gctgaagttt 936781 ggttcgattt ggatgaattg tctttagaag acgtatcaga gccgcttgat tttgttttca 936841 acacctgatt cacgtaaatg gtgtctgatt ttaagttgtt caagaccttc aattcagcga 936901 tggacatatt gactttgttt gcaattttcc aaagtgaatc tccaagctgc accttatatg 936961 ttcccgtaga agatgaagaa cttgaactct tattagaact gctttttgaa ctggagcttg 937021 aactcttatt agagttgctt tttttactgg aactagagct tgaagaaaca gtaccggaca 937081 cctttaattt ctgcccagca cgaattaaat cgctgcttag tccgtttaat tttttcagtt 937141 cctgcaccgt cattttaaac tcatttgcga tcagccaaag tgaatctccg cttttcactg 937201 tgtaaacaga acttccgctc ttcttggttg ttgagcttga agtagatgaa gaagtgctgg 937261 atttgctgcc tggaatagta agcgtctggc cgatcgacag aacagtagtc gaaagatgat 937321 tggcggatgt gagggccgcc acacttgtgt tataggtttg ggccagtttc cataaagaat 937381 ctccgctttt gaccttaatc gttgctgctt cagctggtgt cactactaaa gttgtgccga 937441 caatcgcaga tgctgtcagc cctgctgcta atttcttttt catcttagct ctcctttttc 937501 ccccaatgat tttgcatttg ctgtttcttt tttatatcgg cacatttgtc tcatcgtttt 937561 gcctttttat aaaaatagcc aaattatctt aacaataagg gggaaaaagg gcataaaaaa 937621 agaaggaatc ttaatctatt ccttcatttt taaaagcttc atgatatctt ctttgttttt 937681 gacgaggtcg cgcagtgtgt atttgtctaa aactgcgagg taggctaaaa gcgcttcatt 937741 cagcacatgt tttaagccgc aaaccgggga aataacacag agattcttgt tcgcatcaaa 937801 acattcaaca atattaaaat cgtcctccgt ttttctgaca acctcaccga tgttgatgtc 937861 ttcagggtcc atgcctaatc gtatgccgcc gccccgtccg cgtatcgttt ctacgtagcc 937921 gagctggccg agcctgtata tgactttcat gagatgattt tttgaaatag aatacgtttc 937981 ggcaatctgt tttatatttg aaagttctcc gggacgctct gcagccagaa aaatcaacac 938041 tcttaatgaa taatctgtat aattggttaa cttcataata agacctcaga ataagacatt 938101 ttctatatct tatcataatc gattgaaaaa tgaaaaaaaa ggaattaaaa aacatgcacc 938161 cagctgggtg catgtttttt gcttacatgt cattcggcgg attttggttt ttacggtttt 938221 tttcgatttc tgtgttttgc attttgcgtt caaatgtaga cagataacgt gatgcaaaat 938281 ccttaccgcc aaggccgaag gataaaccaa aagcaagtgc gaagccgcta agaacgatga 938341 tgaacgcgga attgacgatt gtcgcagcga cacccagctg atccagggcc ataaagaaag 938401 caagtgcgat aatcgtatat ttagcaatag gcgctaaaga cttgaattcc tgacctttta 938461 tcatgcttgc gagcactttt ctcaccaatt ctcctgcgta aaggccgagt ccgagaatga 938521 atactgcgac aaggacattc ggcagatacg cgatgatgcc ggtggcaatt tctacgagga 938581 agtgcagccg aacaatttga agcgcctcag ctgtaaagag cagaatgaca atgatttgcg 938641 caatcatacc gacaacttga gacaaggaca gctttgcagg cgttccggct tccatgccca 938701 ttttccctaa gacagaatca aagcctgcgc gatggagcag tccggacacc atggatttca 938761 cccattttcc tgcccagata cccgctaata caagcacgat ggcaatcatg atgttcggaa 938821 gcatgtttaa aatcgtattc agcatagaga cagctggttt tgaaatgccg gcgacatcca 938881 gctgatcaag cgctgaaatg accaccggaa tcataatgag cacataagcg attgttccga 938941 tgactgctga aaggcttgtg tcttttaagt aaattgataa acccatacgt gccgcgaatc 939001 tttcggtgcc gatgcttgca aggaaattcg taatgatatc acggacaagg cgggcaacaa 939061 gccatccgat taatacgata agcgccgctg caaataattt cggcagaaaa gcgagcacgc 939121 tttccatcat atttgtaaaa ggacctgaaa tgccgctgat tttcaaagaa gataagaccc 939181 ctggcagaaa aacaagcagc acgagataaa agacaatttg tgaagcggta ttgacagcct 939241 ggtgaatatc ttttccttca gacaccaaat tccacttgcg cagtttgtca ctcgtgttca 939301 gcttcatccc gatttttttg acaaggaagc tcaaaacaga agctgcagcc catcctaaca 939361 gcagaatgag tccggctttc agcacgcttg ggatcgcagc tgcaatcgcc gaaagcatac 939421 tgacaaacgg cgatgccact gttgtcaggt gcaaaatgtt aaagaataaa ataaagacga 939481 tgatcagtgc gataaaataa acgaccttgc ttatgacttt ttccgaggaa tagcgtgaag 939541 gctttttccc agcaaagagc ttgtcgtcga tttttgtttt gctgagtcct ttgtataccg 939601 ctttttcaat gattttagca atagcccagc cgattaataa gacgagtaaa gcaatgatta 939661 cgtttggcag cttactgaga taagaagaaa acacgtctgc tacattcaat tggtatcgct 939721 cctttttcgt agtatggtgt gtgtttaccc acttatccaa taagcaaaca gatgaatgtg 939781 ccgggggaat tttttcttgc ccgagtgaga ctatcatctt ttgtctggcg ggctcataca 939841 ttatagataa gtccaagtag gggggattcg gttgaacgcg gaggagaaga agggattaca 939901 gcgggcaatt gaggaaatta ccgaaattgc aaaaggattc ggccttgatt tctacccgat 939961 gagatatgaa atctgcccgg ctgaaattat ttatacattt ggcgcgtacg ggatgccgac 940021 aagattcagc cactggagct tcggcaagca gtttcacaag atgaagctgc actatgatct 940081 agggttaagt aagatctatg agctggtcat taactcagat ccatgctacg cttttttgct 940141 ggacagcaac tcactgatcc aaaataaatt gattgtcgca cacgttcttg ctcattgcga 940201 tttcttcaaa aacaactgcc gtttccaaaa cacgaagcgc gatatggtgg aaagcatggc 940261 ggcaacagct gaacggataa aacactatga acaggttcac gggataaaag aagtcgaatc 940321 ttttttagat gcaatccttt cgattcagga gcatatcgat ccgtcgttgg tccgaccaaa 940381 gctccaatgg agtgtggatg atgaggaaga ggagattgaa gaggcagcca cgccttacga 940441 tgatctatgg tctttagatg aaaagaaacc gaaaaaacaa gtgaaaaaat cgaaaaaacc 940501 gttcccgccg cggcctgaaa aagatatcct gctttttatc gaggagcatt cccgggagct 940561 ggagccatgg cagcgtgata tattaacgat gatgagagag gaaatgcttt atttctggcc 940621 tcagctggaa accaagatta tgaatgaggg ctgggcttcc tattggcacc agagaattat 940681 acgtgagctt gatttaacct ctgatgaagc gatcgagttc gccaagctga atgcaggtgt 940741 cgttcagccg tccaaaacag gcattaatcc ttattattta gggctgaaaa tatttgaaga 940801 cattgaaaag aggtacaaca acccgacgga ggaaatgaag aaaatgggcg tgcagcctga 940861 ctccggccgg gagaaaatgt ttgaggtcag ggagattgaa tccgatatct ctttcatccg 940921 caattattta accaaagaat tagtcatgcg cgaggatctt tatttgtttc aaaaacaggg 940981 ccgagattat aaaatcatcg ataaacagtg gaagtcggtg cgcgaccagc tcgtaagcat 941041 gcgggtaaat ggcggttttc catatttgac agtaaacgac ggcgattata tgaaaaataa 941101 cgaactctat attaagcatt ggtatgaggg catagagttg gatttgaaat atttggagaa 941161 agtgcttcct tatttattcc agctttgggg aagaagcgtg cacattgagt ctgtgcttga 941221 ggataaggaa gtcatgtttt cgtacgacgg aaaaggtgtt caccgcagat atttataaaa 941281 aagaggatgc agcgttctgc atccttttta ttttccagtt tttaaaatct taaatatgat 941341 gtttgcctgg tccgtattgt taatcaatcc gcggaatttt tcttttccgg ggccgtacgc 941401 gtataccggt acttcttcgc cggtatgatc ggtactcgtc catccgctgt tggagcgggt 941461 attaaaaatc ttgatgatgg ctttggaggc ccctttgctt ttgtcagcct gtgcagctgc 941521 ttcaacgctt ttgatttctt cagatgtgac tttcagattg gcatagcggg cgagcacatc 941581 tttaaccggc ttgccttcac tgattttttt ggccatgaat tcaggtgttt tcttagcgga 941641 gagaatcggt tctgcgtgcc aattcttttc cccgtttgcg ccaatggtaa agccgccggt 941701 tgtatggtca gcagttgcaa tcacaagtgt atgtttgtct tttttcgcaa attcaatcgc 941761 ggctttatag gcctgttcaa aatctttaac ctcgctcatg gctcctactg tatcattgtc 941821 atgggccgcc cagtcaatct ggctcccttc gaccatcaag aaaaatcctt ttttattttg 941881 gttcaggcga tcaattgctg aaaccgtcat gtctttgaga gacggtgttt tactgtcacg 941941 gtcgagcgct ttagcaagcc ctccatctgc gaaaagcccg agcacctgct gatctttatt 942001 ttttttcaat gcttgtttag ttgtcacata gctgtagccg gcttgtttga attcctttgt 942061 caagtttctg tccttgcggt taaaataaga ttttccgccg ccgagcagca cgtctatttt 942121 atgtttgcct tttatcttgt catccatata gctgttggcg atttggtcca tgtttttccg 942181 tgattcattg tgggcgccat atgcggctgg agtggcgtgg ttaatttcag acgtggcgac 942241 aagccctgtt gacttgcctt gctgtttggc ctcttcaagt acagatttca ctttttttcc 942301 gtttttatcg acgccaattg cattgttata tgtcttaacg cctgtcgcta atgctgttcc 942361 ggctgctgct gaatctgtaa tattatagtc agggtcatcc ggatgcgtca tcatcatgcc 942421 tgtcaggttc cggtcaaatt ctgttaactt cgggttattc ggtgtgtcac cgttattttt 942481 catggaacgg taggctctta tgtaaggcgt ccccatgccg tcgcctatca tcacaatgac 942541 atttctgatc tcagctttgt cttgtttttt ggcgctggcc ttttctgttt gctgaagctc 942601 agctccggca aagattccag ctgtaaggac agaaacagcg gcgattggca gaagttttga 942661 tttcatattt tgaaacaaac tcattttttt catgcctcct ttaatgtatt ccgtttatca 942721 tgttagggaa actttgttaa atgcggctgt tgatcatgta aacaataagt aaagccttgt 942781 aaggaaatga aaaaacgctt ttcgttatct tgccttattt gatgtaaagc attcattttt 942841 cagaaaaatc tttacctctc tgtctttgca tgatatgttt gtttaaataa aaaaactgcg 942901 gataaccaca gctctcctcg aatatacttt atcactcatt tttccgatat atgagccgac 942961 cccgaaagtt tttcatttat ttcctttatg ttgaaaaaca tcccataaaa catgacaaaa 943021 gcactcgttt tttgtcacct ttgcaatgaa aatgaaatat ttaataccct taaaaacttt 943081 tttttagaac gaataattaa gaaatttgtc acatgaagtc aagactattt ctgatgggaa 943141 tctatcctta taatagaaat caataagatt aatttaaaaa aagagataca tatatataga 943201 gttaacattt ggggaggaaa atatgaaaaa gcaaatcatt acagctacga cagcagttgt 943261 tttaggatcg acgttatttg caggagcggc atctgcacaa agcattaagg tgaaaaaagg 943321 cgacacgtta tgggatcttt caagaaaata cgacacaacg atcagtaaaa ttaaatcaga 943381 gaaccacctt cgttcagaca ttatttatgt gggacaaact ttatcgatta acggcaaatc 943441 tacaagttca aaaagcagca gttcttcttc ctcttcttct acatacaaag taaagagcgg 943501 ggacagcctt tggaaaattt caaaaaaata cggcatgaca atcaatgaac tgaagaagct 943561 gaatggctta aaatcagatt tgcttcgtgt tggacaagtc ctgaaactga aaggttcaac 943621 tagttcaagc agctccagct catcaaaagt gtcatcgtct tcaacttcta cttataaagt 943681 gaagagcgga gacagccttt ctaaaattgc gagcaaatac ggcactacgg ttagcaaatt 943741 aaaaagctta aacggcttaa aatcagatgt aatctatgtc aaccaagtat tgaaggtgaa 943801 aggaacaagc acaagcagct caaaacctgc ttcatcttca tcgtcttcaa gcagcaaaac 943861 gtcatctaca tcacttaatg tgagcaagct ggtttctgat gcaaaagcgt tagtcggaac 943921 gccatataaa tggggcggaa cgacaacttc aggctttgac tgcagcggat tcatttggta 943981 cgtactgaat aaacaaacaa gtgtgggcag aacaagcact gcaggatact ggagttctat 944041 gaagagcatt gccagcccgt ctgttggtga tttcgtcttc ttcacaacat ataaatccgg 944101 cccttctcac atggggattt acattggaaa caacagtttc attcatgcag gatctgacgg 944161 cgtacaaatc agcagcctga acaacagcta ctggaagcct cgttacctcg gtgcgaaaag 944221 attctaattt ttagagaaaa cccgttcatt ggaacgggtt tttttcatta gacggagcac 944281 aggcgttttg gttgctccta aaaatgaaaa tgtgataaaa aatccaagaa ctttttttct 944341 ttcttatttt cataaagggc aatcgcgtaa gcgccggcat agggcagctg tacagactga 944401 taaggaattc tgatcatctg tttctctgct aactcacgct ttactgtaga taaaggcaga 944461 aatgaaactc cgagtccttc cttgataaac cgtttcgtta tatgtgtttg agtgaccttc 944521 attgttctca caaatggaaa tgtcattctg acttgacgga gcaagtcgtc ccagtaatca 944581 ggatgattgt gggtcaaaag caggtattgt tcgagcacct ctttggcatc aatttcgttg 944641 tcttctatga aacgcttatc gggcggggca acaaggacga cagggtcttt gtataagcag 944701 tggcagctta aagaagaaga ctgtaccttt aaacagctta gtccgatatc tgcttccccg 944761 gctttaatca gtgacgcgat ttccgctgat tcgaaaatcg taaccgccat ttctgtttcc 944821 gtattcattg ctgtgtaccg cttcatgaca gaaggaagca ctgtatctgc aataagcgga 944881 gaaaccgcga gctgtaaggt ttgagagtag ccttgtctca ctctgtgaag ctctgccatg 944941 ctgttttcat aatcatcaag aagcctgagc gcatacggca aatacgccct gccttcatca 945001 gtcagctgga tttgcctgcc tttacgctcg aacagcttgc agctgatttc tttttctaat 945061 tgcttgatat gtacggtcac agtaggctga gataagaaaa gcgtttccgc cgtttttcgg 945121 aagttctcat attttgcagc ggtcacaaag gtgtgaagcc atttgaaatc catttctatt 945181 ctccctctga ttaatatttt taattaattc cctttaaaat attgattatt ttttaaatat 945241 tatatttact ataataacag aaaaggatag ggggaataca aatggtacat tacggattaa 945301 agggaattac atgtgtagaa acatccatca gccatattga tggtgaaaaa gggcgtctga 945361 tttacagagg acatcatgca aaagacatcg cactgaatca cagctttgaa gaagcggctt 945421 atttgatttt atttggaaaa ctgccttcaa ctgaagaatt gcaggtattt aaagataagc 945481 tggctgcgga acggaatctt ccggaacata ttgagcgctt gattcaatca ctgccaaaca 945541 acatggacga tatgtcggtg ctgagaacgg ttgtttcagc attgggggaa aatacgtaca 945601 cattccatcc gaaaacagag gaagcaatcc ggctgattgc aatcacgcct tctatcattg 945661 catacagaaa aagatggacg cgcggtgaac aagcaattgc accttcttcc cagtacggac 945721 atgtcgaaaa ctactattat atgctcacag gtgaacagcc ttcagaggca aaaaagaaag 945781 cgcttgaaac ctatatgatt ctggccacgg agcacggcat gaacgcatcg actttttcgg 945841 cacgagtcac gttatctaca gagagtgatt tagtgtcagc cgtcacggct gctctcggta 945901 cgatgaaagg tccgctgcac ggaggtgctc cttctgcggt gacaaaaatg cttgaagaca 945961 ttggagaaaa ggaacatgct gaagcatatc tgaaagaaaa actcgaaaaa ggagagcgct 946021 tgatgggatt cggccacagg gtgtacaaaa caaaagaccc gcgggcagaa gctttgagac 946081 agaaagcaga agaggtggcc ggcaatgacc gtgatcttga tcttgcgctg catgtagaag 946141 cagaagcgat tcgtttgcta gaaatctaca aaccgggacg aaagctgtac acaaatgttg 946201 aattttacgc agctgcagtg atgagggcca tcgattttga cgatgaattg tttactccga 946261 ccttttcagc aagccgaatg gtagggtggt gcgcccatgt actggaacag gcagaaaaca 946321 acatgatttt ccgcccgtca gcgcaatata ccggtgccat tcccgaggaa gttctttcat 946381 aacatatttt ggcgtttatt catttctgtc gtgtggtaac gttcagtatc aaccacatgt 946441 ctaggagtga tgaatgtgaa cccaatggac agacaaacag aaggacaaga accgcagcat 946501 caggacagac agccgggcat tgagtcaaaa atgaatccgc tgccgctgtc agaggacgag 946561 gattatcgag gaagcggaaa actgaaagga aaagttgcga tcattactgg aggcgacagc 946621 ggaataggga gagcagcagc tattgccttt gctaaagagg gggctgatat ctccattcta 946681 tacttagacg agcattcgga cgcagaggaa acacgcaaac ggatcgaaaa ggagaatgtc 946741 cgctgcctgc ttatcccggg agatgttggg gacgagaacc attgtgaaca agctgtgcag 946801 caaacagtgg accattttgg taaactcgat atcttagtga acaacgccgc tgaacagcat 946861 ccccaggaca gcattctcaa tatttcaaca gaacagctgg aaaaaacctt tcgcacaaat 946921 attttttcca tgtttcatat gacgaagaaa gctttgcctc acctgcaaga ggggtgtgcc 946981 attattaata cgacatcgat taccgcttat gaaggggata cggcgttaat tgattattcc 947041 agcacaaagg gtgcgattgt ttcctttacg cgttccatgg cgaagtcgct tgcagataaa 947101 ggcatcagag tgaatgcggt ggcgcccggt ccgatttgga caccgcttat tccggcgaca 947161 ttccctgagg aaaaagtgaa acagcacggc ttggataccc caatgggaag accgggacag 947221 ccggttgagc atgcaggcgc ctatgttctg ctggcgtctg acgaatcttc ctatatgaca 947281 gggcagacca ttcatgtgaa tggcggccgt tttatttcaa cgtaatcaac gaaaaaccag 947341 ctcaagagct ggttttttgt gtggtgaaaa atttcaaaat aaaaaatttg tcgatttttc 947401 taacaatttt gttttcattt ttgcaatttt atatataata ttgagtagga gaaaggaatg 947461 attcgcgacc agtacaaata tagtagaaaa aaaagaataa tgaccattgt tactcatgaa 947521 ttcagaaaat tcaaataaaa tatataaaaa tagatgatcg ggagttgaag gggaatgaaa 947581 gggagcgttt ttaggaagaa aagcattcag gatttaatcg ctgcgacgag cggggaaaag 947641 tctttaaaaa gagaattagg ggcatttgat ttaacgttgc ttggaatcgg cgccattatt 947701 ggcacaggga tttttgttct gacgggaaca ggcgcagtca cggccggtcc cgggctgacg 947761 atttcatttg ttgtggcggc gttggcttgt ttattcgccg ccctgtctta cgcggaattt 947821 gcgtcaagtg tgcctgtttc aggttcggtg tatacattca cttatgcgac attgggagag 947881 cttatggcct ttattatcgg gtgggattta attttagaat acatgctggc ggtaagtgca 947941 gtgtcggtcg gctggtctgg ttatttccaa tcgtttttat cagggcttgg cattcatctt 948001 ccggttgctt taacagcggc accgggcgca gtgaaaggca cctttaccct gtttaatctt 948061 cctgcattcg tcattgtaat ggcgatcaca tatttgcttt atttaggcat caaagaatca 948121 aaaagagtca acaatatcat ggttatcttg aagatactgg ttgttctgct gtttatcgcg 948181 gtggcagccg tttacgtgaa gccgcacaac tggcagccgt ttatgccaat gggctttggc 948241 ggcgtgttca gtgcagcggc gctcgtattc tttgctttta tcggatttga cgctgtatcc 948301 tctgctgcgg aagaaacgaa aaatcccgcg aaggatctgc ctaaaggcat tattttctct 948361 ttactggtct gcacgatttt atatgtcacc gtatcagcca tcatgactgg ggttatcccg 948421 tttgctcaat ttgcgggtgt ggatcatccg gtttctcttg ttcttcaaag cgcagggcaa 948481 aattgggtgg caggcatcat tgatattggc gccgtgttgg gaatgacaac agttatgctc 948541 gtgatgcttt acgggcagac ccgcgtcatg tttgccatgt cgcgtgacgg acttgtgccg 948601 ggttcacttt ctaaagtgca tccaaagcac aaaacacctt atgtagccac ttggtttttc 948661 ggaacgatgt cggcgcttct cggctcactt gttccgctgg atgaacttgc aaagctggtg 948721 aacatcggga cgttgtcggc atttgtcctg atttctgtgg cagttatcgt tttgagaaag 948781 aaacagcctg atcttccgag agcttttaaa tgcccgggag ttcccgtgat cccaggcctg 948841 gcgattctgt tctgcctgtt cttgatttta aatctgggat gggtgacgat tgtccgcttc 948901 ctagtgtggc tgttaatcgg cttggtaatc tatttcctgt attcaagaaa gcattcaaaa 948961 ttaaatcaat aaccttttga taaagagagc ggccatacag gccgcctctt ttctgttctt 949021 ggcaaatgaa tctatagaaa tgaagacaaa aataagagat aatataggct ggaaaggaag 949081 tgacgtttat tgtctgagca aaaaccagtc caatgggctt cgaaaattgg tttcgtcatg 949141 gcagcggccg gctcggctat cggcttgggc gcgatttgga agttccctta cgtagcgggg 949201 accaatgggg gaggagcctt ttttcttatc ttcgtgttat ttaccatcct cttaggctat 949261 ccgcttttgg tgggggaatt tatttttgga agacggaacc agacgaatgc cattgatgca 949321 tataaaaaag aagcgccgcg atcagcttgg tttcttacgg ggtggatcgg cgtagcggcg 949381 tgtttcttag tgctgtcgtt ttacagtgta atcgggggat ggattttgct gtatatcgtg 949441 aaaacagcgt caggatcact gtccgggctt tctcaagcac agtatggcgc tctttttgct 949501 tctattatcc aaaatccggt gcagacgctc gcggctcagc ttgtctttat ggcactgact 949561 gtactcgttg tcgcaagagg ggttcaaaaa gggattgaac gggtaagcgc ggtgatgatg 949621 ccgattttgt ttttattgtt tattctgctc gttcttcggt ctcttacgct taatggtgca 949681 atggaaggcg taaagtttct gcttgtgcct catttcggcg atctgactcc ggaatccata 949741 ttattcgcgc tgggacaggc cttctttacg ttaacactgg gggtttcggt gatggtgacc 949801 tacagctcct atttgccgaa aacacaaaat atccctcgtt cggcagcctc cattgtcttg 949861 atgaatatca ttgtgacact cttggcaggt ttggctattt ttccggcggt tttctcattc 949921 ggttttcagc caaatgaagg accgacattg ctgtttacag tgcttccggc cgtttttgaa 949981 cagcttccgt tcggcacatt gttttttatc ggctttctcg ttgcattttt atttgcagcc 950041 ttaacctcag cattttcgat ggttgaaatt atcgttgcca caatcggaaa aggggacgaa 950101 aagaagagaa aaaaactgtc atggacgagc gggcttttga tctttttggt cggaatccca 950161 tgctgcttgt cttatggcgt tttgagtgat gtgcacctat ttggcaaaac gttttttgat 950221 attgccgatt ttaccgtcag caatgttttg atgccttcag gcgctctgtt aatttctcta 950281 tttatcccgc tgaaaatttc gaaaagcgaa ctcttggctg aaatgcgaaa tggatcaaat 950341 gcaggtaaag cattctttta cacatggttt tatttgcttc gttttatcgt gccgcttgcc 950401 attattatcg tgttcttaaa tttaatcgga attttatcat tttaaaaaac aggctccgtt 950461 tccggggcct gttttttatt taataagatg atatcaacgg tgcccatgcc gttttcagtt 950521 tttggatgcc gagcctgatg tcctcttctg acaaaccgcc ataaccgatt aagacagaag 950581 taaaaggcgt ctgttctata tatgagggag acacgggata gagggttaca ccgtggtcag 950641 cggctgcttg tattgcttct tcctcacttg ctggaaacaa aaggcgcagc agaatgtgaa 950701 gccccgagtt cttaccgaga atctcaacgg tgtttcccag ttcagagcga atggcttcta 950761 acaggacagc gtgttttttt cggtataagc ttctcattct atttatgtgt ttttgccact 950821 ctccggtttc gatgaagtct gccagtgcca attgcgagtg ggcagaaacg gtctgcttca 950881 ttaactgaac attgttttgg atcggttcca tgagttcagg gggcacaatc atgaagctga 950941 gccgcaagga aggcagaagt gactttgaaa aagtgcccag atatatgact ctgccattcg 951001 gatcaagacc ctgtaaagac ggaatgggat ggccgctgta gcgaaattct ccatcgtaat 951061 catcttctat aatgaatgaa tttgtttctg ccgcccatgc cagcagctcc tgtctgcggg 951121 taatcgtcat aatggtccca atcggaaact gatgcgaagg agtcgtatac atgagataag 951181 gattctgacg gtagagctca tccggcagga cgccttctgc atcagaacaa atcggagtga 951241 catccatgtg atttgcttca aacatccttc ttgaacggtg aaagcccggt tcttcaaagc 951301 cgatttttgt acctggcttt agcgaaaggc aaagattttg cagaagcacg gtggttcctg 951361 cgccgatgat aatctggccg ggttcacaat ttactccccg agacagcctg acgaatcggg 951421 caatcatgtg cctgagttcg tattctcctt gagggtcgcc agaggtgtga aacgatccgg 951481 aatagcgatc aagacttttt actatgcttt ttctccatgc gttaaaggga aagagggtcg 951541 gatcaacgct gccctgatgg aagtcaatag caggtgcgtt tttttgatgt aatcccggct 951601 gtacagactg ctgaaaatgg tcaggagctg tcgggaatcc tggttctact tccgccgcga 951661 accagccgat tttcggcttg cttttgacat agccctcagc agttaattgc tcataagctc 951721 gttctatagt tgccgtgctg acatcgagca agctggagag cctgcgtttt gacggaagtc 951781 ttgttccctt tgtgattcgc gcatgtgaaa tttcttgttt aaaaaaggta taaagctgtt 951841 catacagcgg tgttttgctc tttttatcaa gaaacggcgt aatatccatc tcatgtctcc 951901 tttgtagctg gcatggtcat tttttctgat attggctatt tggcaaatgc catttattag 951961 ctatgatcat tgtaacgaaa ggaaagggga ttgagaagat gatccatatg aaacaattaa 952021 cctcgaaaga agaatgggct gagtcgtatc cgattatgag tgaattgaga acagaactgg 952081 atatagagac gtatttacaa aggcttgaag cctgtgtgca gaaagaatcg tatatgctgt 952141 ttgccttata tgaaaataca gcaatcagag cgctgtgcgg ggctctgccg agagtttcca 952201 ttcataaagg agagcacttg tggattgcgg atcttgttac aacggcacct tgccgatcaa 952261 agggatacgg caaaatgctt ttggattatg cctcagactg ggcgagaaaa gccggactcg 952321 gttttgtcag tctttcatct ggccttcagc gtaaagacgc acatcgattt tatacagata 952381 aaatgggttt tactatagaa agttatttgt tccgaaaacc ggtataacga aaaaagacgc 952441 ctgaaaaggc gtctttttta aaagccaaac tgtaaattcg tatctacaga tacaatggta 952501 tacacacaaa taatcacaaa gagattaagg atgacgccga gcaggcctgg acctgtgcgc 952561 cctctcttga tgaagagttc aacaacgccg aacggaacgg cagccatggc gaacggaagc 952621 atttgatagg aataaaacgt gacgttgctg ataatggcca aattcagcaa cagcagggac 952681 agaaccgctg tcccgacaga gatccagccg aatacattgt gttctttaaa aattcttacc 952741 agttccataa ttccacctcg ccgacattcg ctgattttac agatttattt ttcagcatgc 952801 gctggatttc cttggttggc cctgtaacga ccgaaccgta tacattgaca ccgtttttct 952861 ctacataatc taatcggtta tctacattca ggtctttccg ttttgaaatg acctgagccc 952921 atttttcgtg tttggacatg aatttcaggg cgttgataaa ctgatcgcca ttcgacttgc 952981 cttttgtatt aagggcggcc aagaactttg aatcctttcc aggatagcca agaggttctg 953041 tggaagctgt cttatttgtg tttttctctg tttcgattgc gttccacaaa aagctcacat 953101 catagccttt gaatttgtta tacacgtctt ttgtcggata tgcacggtca tatgaaaggt 953161 agacctctga taccgttcct tcaggcaatg tgcttaacgt tttttctgct tttgcggtcg 953221 tttgttcaga cttgtttgaa ggatgtgtaa agtaatggcc ggttttattc acttctaagt 953281 catagtagtt tactgccggc gcttttactt tgttataaaa catttcaacc cgttcattcc 953341 ctacggcagc cgtcttcgtg ccaatctgct tttgcagcgg gaattccgta ttcattccaa 953401 atagcttcac ttggcttttc agtccggaag tatcaacaag aacattcggc atggtcaggg 953461 ctacagtgac tgcggcagtt tccataaact cattgccggt gctgtgtttt ccacccattc 953521 cgtaatagag gtagcttccc agcgtacaaa gcggcaaaat catcaatgtc gaaatgacgg 953581 caagcacaga aattcgcaaa taagacttgc gtttgccgta ggctaaaatc gctttttgtt 953641 tttcaggact gatgctgaga tcccaatcgt tatcgtcctc tagttcgctg tcaatcagtt 953701 cctgatatac ttcaagcttc tcgagttctt cctcaaatgc agtcatttcc tggtcgctca 953761 tttccccatt tttatattga tcaaaacgct ttttaaattc ttcattcatc attaacacct 953821 ctattataaa gtgctttcag ccgctgtctg gcacgaaata aaacactttt aaaattcgcc 953881 tctgaaatat tcataatatg ggatgcttct ttgtagttta actcttttaa ataatatagc 953941 gttaaggcct cccgataatt atcggggagc tcggacatat aaccagtcag cacttccttt 954001 atctctacct gatgggcagg actttgaaca gcattttgaa agaggcttcc gattaagtca 954061 tcagaaatgg ttacttcttt cttatgcttt ctgacgtaat caatgaaggc gtttcgcgcc 954121 acttgaaaaa gccagggctt tactttgctg tgatcatagg agtgaatgtg tatgtatgcc 954181 cgcataaagg tttcctgcag taagtcttca gcaagatgct tgtcttttgt catggagagc 954241 aggaacctgt aaacatcatt catgtacatt tggtaaattt catcgatcgt cactgccttt 954301 tctcccctct atgttataca cgcataagaa aggtttaaag ttgcacatta catgcaaacg 954361 gcttttttat acctaatcaa acaccattac tatatagtac ccaaaaatgg ccgcaaaaga 954421 tagtgcggag aaaggtttaa cattttttcc agaggggaaa agatagtgaa aaagtgaagg 954481 agtggcacaa tggaatatac cagtatagca gatacaggaa tagaagcctc cagaatcggc 954541 ctcggcacat gggccattgg cggaacgatg tggggaggca ctgacgaaaa aacatcgatt 954601 gaaacaatcc gcgccgctct tgatcagggg attacactga ttgacaccgc accggcttac 954661 ggcttcgggc agtccgagga aattgtcgga aaggcaatca aagagtacgg caaaagagac 954721 caggtgattc tcgcaacgaa aacggctctg gactggaaga acaaccagct gttccgccat 954781 gcgaacagag cgagaattgt agaggaagtt gagaattctt tgaagcggct tcaaacagac 954841 tatattgatc tttatcaggt gcattggccc gatccgcttg tgccaattga agaaacggct 954901 gaagtcatga aggaattata tgatgcggga aaaatccggg cgattggcgt cagcaatttt 954961 tcaattgagc aaatggatac atttcgcgcc gtcgcacctc tccatacgat tcagcctcca 955021 tataatctgt ttgaaagaga gatggaagag agtgtccttc cttatgcgaa agataacaag 955081 ataacaacat tattatacgg cagtttatgc agagggctgt taacaggcaa aatgactgaa 955141 gaatatacat ttgagggcga tgatctgcgt aatcacgatc caaaattcca gaagccccgc 955201 tttaaagagt atctttctgc tgtgaatcaa ttggataagc tggcgaagac acgttatgga 955261 aaatcagtga ttcacttggc tgtcagatgg atcttagatc agccgggagc ggatatcgct 955321 ctttggggag caagaaagcc tgggcagctt gaggccctat ctgagattac aggctggacg 955381 ctgaacagtg aagatcagaa agatatcaat actatattgg aaaatacgat atcagaccct 955441 gtcggaccgg agtttatggc cccgccgacc agagaggaaa tataacaaaa gctgagggcg 955501 aatcctcagc tttttggcgt ttaaacgaga gaaatcttaa aaattagtac caggtaataa 955561 aaaatattgt tataatagat gacagaaaga atcattgatt acgacaaagg aagtgcgata 955621 tgtataagtt ttgtgcaaat gctttaaaag ttattctttc tcttcgcgga ggagtgaagg 955681 tgtataacaa agaaaacctt ccggccgatt caggttttgt catcgcgtgt acacattccg 955741 gctgggttga tgtgattaca ctcggagtcg ggattcttcc ttatcaaata cactacatgg 955801 cgaaaaaaga gctttttcaa aataaatgga tcggttcgtt tctgaagaaa attcatgcct 955861 ttccggtaga tcgggaaaat cccgggccaa gcagtattaa aacgccgatt aagctgctga 955921 aagaaggaga gatcgtcggt atcttcccaa gcggaacaag aacctctgag gatgtgcctt 955981 tgaaaagagg tgcggtgacg attgcgcaaa tggggaaagc gccgcttgtc cccgctgcat 956041 atcagggccc ttcaagcgga aaagaattat tcaaaaaagg aaaaatgaag ctgattatcg 956101 gtgagcctct tcaccaggct gattttgccc acctgccttc aaaggaaaga cttgcagcaa 956161 tgacagaggc tttgaatcag cggattaaag aactagagaa taaacttgat cagctataag 956221 gcgttctgag agattgtcct gaaactgtga aaataagaaa agcaccctat acaaggtgct 956281 tttcttatta tgcttcctgc tggttagctg tctccagaag ttcttcttct tgaagctttt 956341 tcacttcaat atatgcgacg tggtggccgt caatttcatt aatgatgaat tcgcagccct 956401 cttcgatgat ggaatcatct ttttcaacat cgtatttttg agtaaggaac cagccgccga 956461 ttgtatcgac ttcttcgttc tctaaatgga tgcctagcag gtcgtttact tggtcaatta 956521 acacttttcc gtcaagaata taatggcctt cgccgatttt gcggatttcg ctaatttcat 956581 caatatcaaa ttcgtcgcgg atttcaccga caatttcctc aatgatgtcc tcaaccgtca 956641 caagcccggc agtaccgccg tattcatcag acaaaatggc catgtggacc ctctcttttt 956701 gcattttgac aagcaggtct tggatcggcg cagattcaat gacatgaatg atagggttga 956761 cgaattgaga aatggtggaa tcaacagata cctcaccgct gatgcaggcg gtcagcactt 956821 ctttaatgtt aataaccccg ataatgttat ctttatcgcc ctcttccaca gggtagcggg 956881 tatatttttc aatctgaatg atgtccatca tttcagaaat cttgatatca tgcggaaggc 956941 tgacaatttc ggtccgcgga atcataattt ctttcgcgag cctgtcgtca aattcaaaga 957001 ttttattcac atatttaaac tctgattggt tgatttcacc gcttttatag ctttcagaca 957061 aaatgattcg cagctcttct tctgagtgag ccagttcgtt ttctgaaacg gtctccaggc 957121 caaatgcttt ggtcaataac cgtgcggaat tgttcaaaag ccaaatgaat gggaacgcga 957181 tgcggtaaaa ccaaatcagc ggtttcgcaa acagcataga cactgcttcc gccttttgga 957241 tagcgactgt tttaggtgca agttctccga caacaacgtg taagaacgtg ataatggcat 957301 acgcaaaaat aaacgatatg acatgtgaaa gggaacctgg aacgttcatt tggacgaaaa 957361 gcgggtgaag cagcctttcg atcgttgatt cacctaaaac ccctaatccg atggaagtca 957421 atgtaattcc gagctgacac gcagataaat attcatcaag atgcgtggtc acttttttta 957481 cggctattgc tgctttattt ccttccgcga tcagctgatc gatccgtgag cctctgattc 957541 tgataatggc aaactcagat gccacgaaaa atgccgtcag ggcgattaaa acagcaacta 957601 aaatcaaatt cactatgtcc aattagaacc ttcactctag caatgagaat gaaggtaaca 957661 cctcctgtta gataaaatgg ttttaactta acagcagcat aaatgattgg aacacggcga 957721 gcttttcagg cgggagtttg cttttcagct tgtcacgatc ctcgggcttc agccgttcaa 957781 accgatgcaa gattccggag atgttttgat tcatatgatc aatttctaat gccagatttc 957841 caatttcatc atcaagttta gctgaagagg gaaactggtt ctccagtcga tctttaatat 957901 cggacagggc caatcgctgc ttcttgcaat ctacaataaa tataagtcgt ttgagtgcat 957961 tttcgtcgta gtaacggtaa tttgaacagg atctggccgg cgtaagcaga ccgagattcg 958021 tataataatc aactgtccgt ttcgttactc cggcgagtgc cgctagttca ctgatgcgat 958081 aagtctcagc cccatctata tccctcccaa ccatcacgtt atagttatga gaatagttta 958141 atatatgaac ggtgtcttgc acaagtttat tgtttttttt agaccggaat tggaagttgt 958201 ggaattcatc atctgattga agtaacatag gaagatagaa ttttcaaatt tttatatgcg 958261 gaagggacag atgaaattgg ctgggttatc ccgggaagtt gaagaaaact taaataaagg 958321 atcatggatt cgcaagctgt ttgatgaagg tgcaaggctg aagaaggagt tcggggaaga 958381 ccaggtattt gatttttcac tcggcaaccc gattgttgaa ccgcctgaag cttttaagag 958441 agcgttaata gaggaagctg aaaaaggcag ccacggatac atacaaaacc aagggcttct 958501 tgcagcgaga gaaaaagtcg cgcaatttct gggctcgcgt tttgaagctg atttctcagc 958561 ggagcgcatc gtcatgacgg tgggcgcggg aggcgctttg aatgttgcgt taaaaagcat 958621 cgtaaaccct ggggaagagg tcattattct tgcaccttat tttgccgaat ataagttgta 958681 tattgagaac tacgggggaa aagccgtcag ctgcccgttg acaagccggt ttgagatcga 958741 cattgaagcg gtaaggcaat cgatcactcc acagacgaaa gggctgattc tcaatacacc 958801 gcataacccc acaggcactg ttctcagcca gaaaaatata gacgatttag gcgctttatt 958861 aaaagaaata gaagagaaga gcggccagac gatttatgtg ctgtttgatg aaccgtacag 958921 tcaattaatc tatgatgaag agctggcaaa tccgtttcaa tcgtaccatc gtgtgatatt 958981 ggccagctca ttcagtaaag atctcggcat agccggagag cggctcgggt atatcggatt 959041 ggacagccga atgccggatg cggacctttt gatcaacgct tttgtgtatt gtaatcgaac 959101 gcttggattt gtgaatgccc ctgtcatgat gcagcgggct gtggcacgaa tggatgattt 959161 aagagtagac gcgagcgctt ataaagagcg ccgggattta atggtagaca ttttaaaaga 959221 agccggtttt gaatttgaaa tgccaaaggg aggtttcttt gtttttccga aatcgccgat 959281 tgaagatgaa gttgcatttt gcgtgcatgc cgcccaaaaa tacaaattat taattgtgcc 959341 gagcagcggt tttggaatga gcgggcattt ccgattatcc ttcagtgtgc cgatcgagca 959401 gattaaaaac tcacgggaca ttttcatttc tttatataaa gattttgctt aagaaggcaa 959461 agaaaagaaa acagttttca aggctgtttt ctttttatat ccgcaaaatc cttcctcttc 959521 caatccagac aggcgcagaa ttgacaagca ggcatgcagt taaggctttc ttcatgataa 959581 aagtctaaaa attaaaaatc atttttggaa tgagttgtgt tacaataaaa tatacaattt 959641 ataatcaaac tttgactttt ggaggtggta tgatggggcc ctctgcttag gcaacaatac 959701 accgcgtacc tcaatgttaa ggaaaaatga ttatatcagg aggtgactcc ttatcctttg 959761 ttgagaggat agggttaaat ggacgatatt gacagtctga ttttaattgg cgtgctcatt 959821 gctttaaccg cgtttttcgt tgcaagcgag tttgcgattg ttagagtgag gagatccaga 959881 atagatcagc ttatcacaga aggaaacaaa cgggcgatac tcgcaaggcg tgtcattaca 959941 gatttggatg aatatttatc cgcatcccag ctaggcatta cattgacatc aatcgggctt 960001 ggcgtactgg gtgagccggc ctttgaacgg ctgctgcatc cactgtttga accgctcggc 960061 ttgccggact cggtttcaca tgcagtctct tttgcagtcg cgtacggctt gatcacgttc 960121 ctgcacgttg ttgtaggtga actggccccg aaaacggtcg cgattcaaaa ggcagaacag 960181 ctgactttac tgatagcggg ccctttgcgt ttattctatt tgctcctgtt tccgtttatt 960241 tggatcctca atggatcggc gcggctttta tgcgggatgt tcggtttgaa gcctgcgtca 960301 gaacatgatg gttcccattc tgaggaagaa ctcaggatgc tgttatctga gagtttaaaa 960361 aacggagaga ttaatccgtc tgaatataaa tatgtgaata agatttttga atttgataat 960421 cggatcgcca aagaaattat gataccgcgg aaggaaatgg ctgctgtgtc aactgagatg 960481 acgatggccg agatgcttga agtcatgctg aaggaaaaat acacgcgctg gccagtcaca 960541 gatggagaca aagacagtgt gctcggtttg gtcaatacga agcatttgtt ttctgatttg 960601 ctgtttatga cagaagaaga acgaatgaag atgacgatcc atccgtatgt gaggccggtc 960661 atcgaagtga ttgaaacgat cccggttcat gacttgctga ttaaaatgca gcgcgagcgc 960721 attcatatgg ctatattgtc ggatgaatac ggaggaacct cgggacttgt gacgacagag 960781 gatattcttg aggaaattgt cggagagatc cgagatgaat ttgatgaaga tgaacagccg 960841 ctgatccaaa agcttggcga cggccattat gtgatggatg gaaaggttcg gatcgatcag 960901 gtgaacagcc ttcttggcgc atcgattcaa gaagacgtcg atacgatcgg cgggctgata 960961 ttaaaagaaa acatcgatat tgaggctggt gaatccattc gcatcggttc atatacgata 961021 aaggtgctga agatggacgg ccgattaatc aagcaaatcg atataaaaga agaagccggc 961081 aacacaaccg ggattacggc gcaccacaag ctgccgctgc ccgagcctgt gatgctgaac 961141 agtgcaacct tgagcgagaa ataagctcaa ggttttttta tattgtgatt gtccagccgc 961201 accaaaatgc aaaaagcgac ccgcaaagtg tcaggacgat gtacaagatg ctttctttta 961261 cacgtttggc cataaggagt tgaatagttt caacgctgaa tgtggaaaag gtcgtaaagg 961321 cgccaaaaaa ccccgtgcca atgataagcg agaccgaagc atttgcaacg tgaagtcctg 961381 taaatattcc gagcccgaga gctccgagaa tattgactgt cagtatgcca atgggcaggc 961441 tgagaccttt ggttttggcg gttatgacat tgccaagcca gaagcgaagc attgcgccaa 961501 gtccgccccc tatgaaaata cccgctagtg tcatttttcc tgcagcccct ttctttgctg 961561 aatgcctgct atgcgccgtc ccacaaaaac accaatcagt gcaaatatga tccctgatat 961621 caatgaggct gccacatata aaagagccaa tgagggttgt ccttgcaaaa gcatcactgt 961681 ttccttagaa aacgtggaca ttgttgtgaa gcctccgcaa aagccggtgc ctaaaaaagc 961741 cgacagcaga ggccgttttg ccccgatcat aaaaaatccg gtcaaaatgc ctaatagaag 961801 gctgcctgcc gcattttcca gccaggttgc cgccgggaac tgaccggtgt gtatccataa 961861 gtttaatccg tatcggaggc aggcgccaag cgcgcctccg ataaaaaccg cgctatatat 961921 tttcatgttt gccatccttt atgatgaaat ccgggtaatc tgtaacgatg ccgtccacgc 961981 ccatggcttg taattttgcc gctgtctttt gattgttgac agtccatgca aatatgttta 962041 agccattttt attgatggag ccgatcatca gacggttaag ccgtgtgtgt tttatattga 962101 catagtttgc aaaagagcgg aaggccttca tctgatttct ggacagcatg ccaaagttgg 962161 gccttgtaat gaccgctgtc ggaatcgaag gataaagctc gcggaacctt tggacggagc 962221 ggaactgaaa ggattgaaca atattattga tagaaaaaga aaattgccct aatagctgtc 962281 ccacctcttc ttcaattccg acttgagacg gatggccttt tagttcaatt aaaaggccga 962341 tttttttgtg gtagcgcttg agcaccgctt ccagggttgg aatacgctct ccttgaaaag 962401 cgggaccgta ccagcttcct gcatcgagtt tttgcaattc ctccaaggta aaatccttaa 962461 caaagcccga tccgtttgtt gttcggtcaa ccctgtcatc gtgtatcaca acaatctgcc 962521 tgtcttttgt aagctggaca tccagttcga tcatatctgc attcattttc accgcaaggt 962581 caaatgcggc aatcgtattt tccggagcgt agccggatgc tccgcgatgg gcaatgatgt 962641 acaagctaag tcagctcctc gtatgggcat ttctgttatt gtatcaaatc catatatgca 962701 ccgcgataca aactggtgaa ttttttctgc catatcggaa tggtccgggc tgaggaatgc 962761 gtataactaa aaaaagacac tcagcgtatc agaacacatt tcgtcagaaa attaggtctt 962821 tcgacatgtt cacaacaaaa tatgatcctt tataatagca aaaaaggagg cgagatcatg 962881 ggaaaaggga gaatcagagt ggaggaaaga attaaagccg aaacggatgc tgaaatgcaa 962941 aaagcaactc tccttgatca gacacaaacg aaaaaaggta agtgactgtc cctattgaat 963001 ctggctgata gatgaattga gaaatgaccc cggcgtttcg ccggggtttt gtgctgcata 963061 agacatttaa atgaacatcc ttacgaatat tttagtataa taaacaattg attgggatag 963121 aggggagaca gtcatgccgg attatctgca gcagtatttt acgcttgata acatcataca 963181 aatcggcatc agcttggcga ttttgctggt gtttcttata cttagaaaat tattcacaag 963241 atattttttt aacctgcttt ttaatttgac aaaccggccg aaaacagaaa tttttaaaca 963301 ggtggttctg gcgtttgata agccggccag atggtttttt gttgcccttg ggctgttttt 963361 agcgatccgg tattcaccgt ttttagatga gcaaatgccg gtcatcagca aaatataccg 963421 ctcactgatt gtggcgctct tgtgttgggg tctttgtaat ttgaccgcaa catcgtcgtt 963481 tatcttccat aaggtgaacc agcgcttcga gcttgacatg gatgacattc tggccccgtt 963541 tttatccaaa ttgctccgtt ttgtgatcat tgcgctcagt gtcagtgtga tcgctcagga 963601 attcaattat gatgtcaacg gatttgtagc gggccttggt cttggcggac tggcttttgc 963661 gcttgccgcg aaggatacca tcagcaactt cttcggcggt attatcatta ttactgaaaa 963721 gccgtttaca attggtgact gggtggagac gtcgacagta acaggatcag tcgaggatat 963781 tacctttagg agcacgagat tcagaacagc acagggggcg cttgtaacgg tgccgaactc 963841 tacgctgtcg atggaagcga tcacgaactg gacaagaatg accaaacgcc agattacgtt 963901 ttccatccat gtgtcctacg ctacgccgat tgagaacctt gaacgctcca ttcattctct 963961 cagaacaatg ctcttagagc atgagggcgt tgataatgaa ataatcatgg tcaactttga 964021 tacgtttgcc gacagctact acaatttatt ttttaacttc tatacaaaaa cgacggtttg 964081 ggctgaaaac cttaatatta gagaggatat caactataaa attattgaga ttttaggtgc 964141 agaaggcgtt cagtttgcat atcccggcca aatggttgtt gtcaagcaaa agcacgaaag 964201 cgaccaattc caggtgaatc taaataaaga ggaaaaggaa cgggcttaaa agagagactt 964261 cgtctgacag aggcggagtc tttttcatgg taaaataaga gaaaaaggcg gtgttgagtt 964321 ggaaacattc aaaagtattc tacatgaagc acagagaatt gttgtgctga ccggagcggg 964381 aatgagcaca gaatcaggga tccccgactt tcgttcagca gggggcattt ggacggagga 964441 tgcctcaaga atggaagcga tgagccttga ttatttttta agttatccgc gtctgttttg 964501 gcccaaattc aaagaattgt tccagatgaa aatgagcggc agctttgaac cgaatgaagg 964561 ccatttgctt ttagctgagc tggagaagca agggaagcag gtcgatattt tcacgcaaaa 964621 cattgacggt cttcataaaa aagcggggag caggcatgtg tacgaactgc atggttctat 964681 ccagacagca gcttgtccgg catgcggcgc ccgatatgat cttccccatt tgctggagcg 964741 ggaggtgccg gagtgcacgg cggccggaaa caatggggac atttgcggaa cggtattaaa 964801 aaccgatgtt gttctctttg gcgatgccgt catgcacttt gacacccttt atgaaaagct 964861 ggatcaagca gatcttttat tggttatcgg cacgtctctc gaagtggctc cggctagatt 964921 tgtgcctgag gatgcaagcc tgattcccgg catgaagaaa gtcatcataa accttgaacc 964981 aacgtattgc gacagcttgt ttgacatggt catccatcaa aaaatcggcg agtttgcccg 965041 aagtttgggc atgaaaaagt gagccgcttt atgcgcctca cttttttatt catgaacagg 965101 aaccattgtg tcctctaaca ctccgaagga atagcctttt tcttttaatt tattgattag 965161 taccggcagc gcatttacag tagcaggaag atcatgcatg agaattacat ttgggcggct 965221 tgaagagctg tgttccatat tctcaagctg ctgtaatacg gcggtcacat actgtgaatt 965281 ccggtatttc cagtccatgc tgtcgatcgt ccaatcccag tacacaaacc catctttctc 965341 cagattgcga atttgtgagg cggttagtga cggcttgctt ccgtatggcg ttctgacaag 965401 atcggtttta tatcctgtaa tgtcctgcag cgtgtcacgc gcctcctgca tttcttttag 965461 cggagatgtc ggtgtttgat agaacaatct gttattgtgg gtaacgccat gtaaaccgag 965521 tgcgtggcct tccttttctg ctcttttcac agcctgcttg aattcgttca tccgcggtga 965581 cagcataaaa aacgtcgctt ttacatcagc gcttttcagt acgtcgagca agcgggttgt 965641 aacggctgaa gggccgtcgt cgaaggttaa gtaaaccgtt ttatctccca tgttctgctt 965701 tgtctgcaga tgttttatca ggagatcggg ggagtcgttt ttcagcttaa ggctttcctt 965761 ctcatctcga agctggccgt ttgttgtgac agtgacttcc tttgctttcg ttgaactgtt 965821 ggaataaccc aaaatcacca taagcaaaag cagcacacat aaaactgcta aacttgcaaa 965881 tttaaaagca agcgaaactg cagaaggaga agcctctcct ctcgtttgtc gcataacaat 965941 ctctccattg gcataaaatc tctacataat gctgtacagc aggcagctta tgaagatgcc 966001 ttatgtttac aacctatgta ttaccagtca agtatacagg aataaaactg gaaagcacat 966061 agaaaatttg tcgaaatgtc agattttaag gaaaaaataa actcctttcc gctatagatc 966121 tcttgatctt tctgtttttc agcttgtcca atatggtaga attagtgata atgacagctt 966181 gaatgacatc agggacatct cgaaaaggga gggcttttat gaaggtttta gtcaatggcc 966241 ggctgattgg gcgcagtgaa gcatcaatcg atttggaaga tcgcggttat cagtttggtg 966301 acggcatcta tgaagtgatc agggtgtaca aaggagtatt gttcggctta cgtgagcatg 966361 cagagcgttt tttcagaagt gctgctgaaa tcggaatttc actgccattc agtatagaag 966421 atctcgagtg ggacctgcaa aagcttgtac aggaaaatgc ggtcagtgag ggagcggtat 966481 acattcagac aacaagaggt gtggccccgc gaaaacacca gtatgaagcc ggcctcgagc 966541 cgcagactac tgcctatacg tttacggtga aaaaaccgga gcaagagcag gcatacggag 966601 tggcggccat tacagatgag gatcttcgct ggttaagatg tgatatcaaa agtctgaatt 966661 tactgtataa tgtcatgacg aagcaaaggg cctatgaagc cggagcattt gaagccattt 966721 tacttaggga cggcgttgtt acggagggta catcctctaa cgtttatgcc gttatcaacg 966781 gcacagtgcg aacacatccg gctaatcggc tcattctcaa tggaattaca cggatgaata 966841 ttttaggact gattgagaag aatgggatca aactggatga gactcctgtc agtgaagaag 966901 agttgaaaca ggcggaagag atctttattt cgtcaacgac ggcagaaatt attccggtcg 966961 tgacgctcga tggacaatcg atcggaagcg ggaaacccgg accggtgacc aaacagcttc 967021 aggctgcttt tcaagaaagc attcaacagg ctgctagcat ttcataaatg aacgaagaaa 967081 agagcccgct ttttacagcg gggctctttt tattttttaa caaatccaat caaaatggag 967141 atcattggcg atatatagag gaagaacgta aatgggatgt agtctatgac tggaacacca 967201 agtgcgctcg ccataaatgc gccgctgacg ccccaaggaa tcaatgggtt aattaatgtt 967261 ccgccgtcct ctaatgatct tgtcagaaat tttcgctgga tgtttcgttt gtcatataaa 967321 gatttaaatg attgtcccgg tattaatatc gataaatact gttcgcccgt tgccaagttg 967381 acgccgatgc ttgagcagac agttgctgca acaagacggc cttttgagcg gatgcctttc 967441 atgacgcctt ccaatagtgc agaaatcaat ccgattttct ccatcaatcc gccgagtgca 967501 aaagcaatca taatgagaga gacagagccc atcatggatt gcagtccgcc tctgttaata 967561 attttagcgg ctgcctcatt gtcagtttcg aaagttgtgc cattttgtaa agctgtcata 967621 aacgcctgca ggctgctgta gggtacaaaa atagcagtca aaattcccga ggaaataatt 967681 ccggcagtca gaacggggat tactgatacc cgtttcattg ccagcaaaac gactaagagc 967741 ggagaaagaa gggcccacgg tgtcacgttt gcagcatctt ttattccggt tatgacctgc 967801 tgaatattat cggttgaagc agcgtccgct gacactgatg aaccgagaaa gtaaaacaga 967861 acgacagtga tgagcaaagc tggaatggtt gtgcccatca tatggcgaat gtgttcaaag 967921 attggtattt cgcctattcc ggctgcaaag ttggttgtgt ccgacatcgg cgacatttta 967981 tccccaaaac aagcgccgca tatgactgcg cctgctgtcc attcaagcgg aacgccagcc 968041 gcgctcgcca cgccgatcag cgctactccg attgtgctta cagttgtcag acttgagcca 968101 acaagtgtgc tgatgatcat acatgaaaac aaagcagtca acagaaggtg gcttggttca 968161 ataaaggata gggcataaac tgtcatagtc ggtattgcgc cgctgtacat ccaggcgccg 968221 attaagatgc cgatcagcgc tagaacaata atcggctgta cgccgttttt gatcccgtct 968281 acaatccctt tttcaatgct cttccaggga aatccaaacc ataaagctgc tgctgaaagc 968341 atgacaacac ttaaaaacag cgggatatga ggttctacat gaagcaagaa taagcaagaa 968401 ataataatgc acaacatgaa tataaataaa ccgacggcta acggaaacgt cagctttttt 968461 tgagaatcca aaataacacc ccatatttat ctttaatgct tttgtgcttt tgggcacgaa 968521 agcattataa cagaaaaaaa cgaaaatcta tgttttttca caattatgaa tataaaagaa 968581 gtgagcacag ggcgtgctca ctttacaatc aggacgggta tatccgattt cgctgaaagc 968641 ttttcactta cacttccgaa tattagcttt ttcagcctgt tttggtctct gcttccggtt 968701 acgatcatat cggcagaaat gcggtttgca tgctcgataa ttgattcagc cggatcgcct 968761 tctaatatat cgatatctcc atctgcctgc tgttcattca gcatcattct ggcttcggcg 968821 atgacttctt ccgtacggtc ttcatagatc attggctcag gtgatgttac atccgatatc 968881 agcggatcag gaacacttgt catgcctccg ctgatatagc ttgcctcagc tgcgggtctg 968941 ggcgggtcga tgacggtctg attgtctttc atatcatgtg aatgggcgac ggtaatagcg 969001 gcatttacgg ttttagcaag atcaatggct gtcagaagcg ctttcttact attttcactt 969061 ccgtcaaacg caacaatgat acggtcagca tggaacatcc ttctcaccct ttcaaagcgt 969121 cttacaacac tactacccga atttgagcac aattaacctt ttcctattca agtaatgatt 969181 gacaataaaa ggttttgttt atatgatgat aaaaagatga aatcagaatg gaaggagggt 969241 ttgctatgcc aaggaatttg cgtgtttatc aaacagtttc atattggcgc ggcaaacctt 969301 ttgttctgtt ttcgtgaacg gttttttagg tcggaccgcg cgctgaaaag cgctgtgcgt 969361 aacatatcgg ttaaaaaagg catggagctg acgcttcatg ccttttttat atacaaaatc 969421 taaggaaaga caggtgtatg ggatgtgaag acaaatacag aggcgagggc agttcgtgcc 969481 aaactggatg aaaaaagctg caaggaaaaa atagaaggcg gctgatgagg agatggggat 969541 agatgttttc agttttgaaa aagcttggct ggttttttaa ggcgtactgg ctgcgctata 969601 cgattgcgat tgtcctttta ttagcagtca atgtcattga aatgtttccg cctaagctct 969661 tggggaacgc catagatgat atgaaagcag gggcatttac tgcggaaggg ctgctgtttt 969721 atatcggtat cttttttgtg ctgacggcgg ccgtgtatat catgtcttat ttttggatgc 969781 atcagctgtt tggcggagcg aatctgatgg agaaaattct tcgtacgaag ctgatggggc 969841 atttgctgac tatgtcgccg ccgttttatg aaaaaaaccg aacaggcgat ttaatggcac 969901 gagggacaaa tgatcttcag gccgtcagtt taaccacagg gtttggcatc ttgacgttag 969961 ttgattctac gatgtttatg atgacgatct ttttgacaat ggggtttttg atcagctgga 970021 agctgacctt tgccgccatt atcccgcttc cagtcatggc gattgcaatc agtctatatg 970081 gaagtaaaat tcatgagcgg tttactgagg cccaaaacgc gttcggggcg ctgaatgaca 970141 gagtgctgga atctgtttca ggcgtgcggg tgattcgcgc gtatgttcag gaaacaaacg 970201 atgttcgccg gtttaatgaa atgaccgctg atgtttatca gaaaaatatg aaagtggctt 970261 ttattgattc actgtttgag ccgacggtaa aactgcttgt cggcgcaagc tatctgattg 970321 ggctcggcta cggagcgttt cttgtattcc ggaacgagct gacgcttgga gagttagtgt 970381 cctttaacgt ttatctcggc atgatgattt ggccgatgtt tgcaatcggt gaactcatta 970441 atgtgatgca gcgcggcaat gcgtcattag atcgggtaaa tgaaactctt tcttatgaaa 970501 cggatgtgac agatccaaaa cagcccgctg atcttaaaga gcctggagat atcgttttca 970561 gtcatgtcag ctttacatat ccaagctcaa caagtgacaa tcttcaggat atttcattta 970621 cggtgcgaaa agggcagact gtcgggattg caggtaaaac cgggagcgga aaaacgacaa 970681 ttattaagca gcttttgcgc cagtatcctc caggtgaagg gagcattaca ttttcaggtg 970741 taccgattca gcaaatccct cttgaccgtc tccgcggatg gatcggatat gtgcctcagg 970801 atcatttact gttttcacgg actgtaaaag aaaatatttt atacggaaaa caggatgcaa 970861 ctgataaaga ggttcagcaa gccattgccg aagcacattt tgaaaaagat ttgcacatgc 970921 ttccgtccgg tctggagaca atggtcggtg aaaaaggcgt ggcactgtca ggcgggcaga 970981 aacaaagaat ttcgatcgcg agagcactca tggcgaatcc ggaaatcttg attctggatg 971041 attcactttc cgctgtagat gccaaaacag aggctgcaat tatcaagaac atcagagaaa 971101 accgcaaagg aaaaacgaca tttattttga cacaccgatt atccgcggta gagcacgctg 971161 acctgatcct tgtgatggac ggcggcgtca ttgctgagag aggcacgcat caagaactgc 971221 tggccaataa tgggtggtac cgggaacaat atgaaagaca gcagctgttc actgcggaag 971281 aagggggagc aggggcatga aaataggaaa aacgttatgg agatacgcac ttctttatcg 971341 aaaattgctg atcacagccg tccttttgct aactgttgcc gtcggtgcag aactgactgg 971401 gccctttatt ggcaaaaaaa tgatagacga ccatatcctc ggcattgaga aaacatggta 971461 tgaagctgcg gaaaaagata aaaatgccgt tcagtttcac ggcgtctcat atgtcagaga 971521 ggaccgattg caggagcctg tttcaaaagc aaaagaagcg catatttatc aagtgggaat 971581 ggcgttctat tttgttgatc aggctgtcag cttcgacggg aatagaacgg tttctgacgg 971641 gaagctgacg atcacaaacg gagacaagag ccgggcatat gctgccgaaa agctgactaa 971701 gcaggaactt ttccagttct atcagccgga aataaaggga atggtgttac tgatctgcct 971761 gtatgggggc ttgcttgtgt tttcggtatt ctttcaatac ggacagcatt atctgctgca 971821 gatgagcgcc aatcggatta ttcaaaagat gaggcaggac gtgttttcgc acatacagaa 971881 aatgccgatt cgctattttg acaaccttcc ggccggaaaa gtcgttgcgc ggattaccaa 971941 tgatacggag gctattaggg atttatatgt cacagtgctt tcaacatttg tgacaagcgg 972001 aatctatatg ttcgggatat tcacggcttt gtttctgctt gatgtgaagc ttgcgtttgt 972061 atgtctggca attgtgccga ttatctggct gtggtcggtc atataccgga gatatgcgtc 972121 atattacaac caaaaaatcc gctcgatcaa cagtgacatt aacgcaaaaa tgaatgagtc 972181 aattcaaggc atgaccatta ttcaggcttt ccgccatcaa aaggaaacaa tgagagaatt 972241 tgaggaatta aatgaatcac atttttattt ccaaaacagg atgctgaatt taaactcctt 972301 aatgtcccat aatctggtca atgtcatccg caatcttgcg ttcgtctgtc tgatctggca 972361 ttttggcggt gcgagcctga atgcggcggg gattgtttct atcggtgtgc tgtacgcgtt 972421 tgtcgattat ttgaaccggt tatttcagcc gatcacaggc atcgtcaatc agttttcaaa 972481 gctggagctt gcaagggtct ccgccgggcg tgtttttgaa ctgcttgaag aaaagaatac 972541 ggaagaagcg ggtgaaccgg cgaaggagcg cgcgctgggg cgggttgaat ttcgtgatgt 972601 gtcatttgcg tatcaagaag gtgaagaggt attaaagcat atttccttta ctgcgcaaaa 972661 aggcgaaacc gtagcgctcg tcggccatac cggatcagga aaaagctcga ttttgaatct 972721 tctgtttcgt ttttatgatg cgcaaaaagg tgatgtctta attgatggaa aaagcattta 972781 caacatgtca agacaggaac tcagatccca tatgggtatt gtgcttcagg acccgtactt 972841 attctcgggc acaatcggat ctaacgtaag tctggatgac gaaagaatga ctgaagaaga 972901 aataaaaaat gcactgcggc aagtcggtgc tgagcctctt cttaagaagc ttccgaaggg 972961 cattaatgag cccgtgattg aaaaaggcag cacgctatcc tctggagagc ggcagttaat 973021 ttctttcgct agagctttgg cgtttgatcc cgcgatcttg attttagatg aggcaacggc 973081 gcatattgat acagagacag aggccgtgat ccagaaggcg cttgatgtcg tcaaacaagg 973141 acgcaccacc ttcgtcatcg ctcaccggct ttcaacaatc agaaatgctg atcagatttt 973201 ggttcttgat aaaggagaaa ttgttgagag agggaaccac gaggaactga tggcattaga 973261 aggccaatat tatcaaatgt atgaactgca aaagggacag aaacattcca ttgcataacg 973321 ctcaaaaacc caaaacaatc gtgttttggg tttttggttt atgtagtcaa taagccagtc 973381 cgacacggtt tccgacatac tcacctgtaa cgagctcacg atataaaaag tccgcagtat 973441 cgccgaccga aatgcttgtg ccgccctcag gcaaaacgtt acgctccgta cgataaacgc 973501 cggttgctgt tccgtccggg aggtaagtgg ggcagatgat tgtccagtct aatgatgatt 973561 ctttaagcat ttcgtatact tttgcatgct ccttggctgc gcgggtctgc tttcgtttcg 973621 attcatttgt ttcaaaccgg tattttcccg gttcatatcg ggaatctagg atccctgcgg 973681 tgccgatcgt aataagccgt ttgatatgct gttcctccat aacggagaga atgtgtgcca 973741 tagcagttga caaggtatca tcaccatctg tgcctagaca gctgatcacg atttcagcat 973801 tctccattat ttttttcaca tcttctaagc ggcgggcgtt ccccatgaca gttctgtctt 973861 ttgaaagggg aagatcagca tgttgagatc tgatcagagc gaaaatatca aatctttcat 973921 ctgctgcagc ttgtgttaaa aaggcttgtc cgacgcggcc gctggctcct aataaagcga 973981 ttttcattaa aaaacctcct cgcctttcat tataaaagga tgttctcagt ttgaacagcg 974041 cgggaaagaa tacctgtaca aataaacaga acgatgggaa acatattcat gaatcatgga 974101 tacacttacg aattgaacca gctcccaatt cacaatggtg atgaatgaca ccccgattcc 974161 ctcccttttt ttctaggata tgtggagcag gaaaaaaggg tgacaaaata aagagagcgc 974221 ggaaaccgcg ccctctatag ccatatattg aattgttatt gaactctgcc gcccatttgc 974281 tgctgagcga aagatactaa acgttttgtg atttctcctc cgacagaacc gttagcgcga 974341 gaagttgtgt ccgctccaag gttaacgccg aattcagaag cgatttcaag tttcatttga 974401 tcgatagcct gagctgcgcc aggaactagt aagtcatttg aagagttttg gttagccatg 974461 tgtaaaatct cctttttatt tagtatggtt gggttaactg gagttgcacc aatctgtgaa 974521 cccttctcgg gtgtcactgc cgcctcggcg taacccaatg ctttgccggc ttgttactac 974581 gtattatgtt aaaatggccg gaaaatcatg cggagaattg tgtggtaaat cttgagaaat 974641 aaaaaaagct tagccgttta ggctaagcta gtcataaata tgaaaaagca tcagttcatg 974701 tatctcgttt gtaagagcag gctcgtcagc gcgggcggga aacaagtctc cccattcaat 974761 ctcaccgctc ttatgataga tgccttcata atgggtccct ttataataaa atgaaatttt 974821 ccatccgggc agcttttctt ttgggaacaa aggtttccag ctgaaatgag aaatcattac 974881 ggccacgctc cttacatttg gtatcaattg acctaaataa aaacggctta tgttcattgt 974941 atcattgttt cagaacatca ttgaagaggc ctaaatatgc agtttgtccc agctttggat 975001 aaagataagc ccgctttatt aaaaaagcgg acaggttacg aaggccacaa tgcttccgga 975061 gatgtgattg ccttctcaga taaatatgac gcgtattcaa aacttcttcg ttttgtaaga 975121 gaatcaacat gatgcaaatt tggatgagaa aaaatgcttc ggcccgggcg cgaattcgct 975181 tcaaacatcc atactttacc gttctgatca atgccaaaat cgaaaccaat ctccccgata 975241 aatccctcga tatgatcatg aaggacatgg cttgcagtca gtgccgctgc agaaagcttt 975301 ttaatgacct caactctttc agcgggatca tcgtatactt ccgcaagtgt ctttacagtg 975361 ccgccgttag aaagatgtgt tgtaatgctg ttctttccgg aaatttttac ggcgattgct 975421 gtcactgtcc attttccttt tctgttttta ttggtatgga cacggaaatc cgctggtttg 975481 ccttgaaatt cgatgagatc aacaccttgc tgaatgagaa agtcggacgg gttgtgatgt 975541 ttttgaaatt ctgcaaggaa tgaggcggca tcggaataat caattgatgt aaaagttttg 975601 gcgtcattcg tatgctttac cgtcaggccg ccatctgttc ttgtcagctg ataaatgccg 975661 gtgccgagtg ctccatttgc cggtttgata tagacttttt tgtatgcgcc acagagctca 975721 tctatcagct ccacagacgg tgtcagctcg gatctaggca aaaagggtgc cgttcttgga 975781 tctttttcga gcaattgatg aacgttccat ttattgaaaa acgttttatt aaaccatggg 975841 atctgatatt catcgatcag cctctttttt gtatgttgca agagaagtga atcttcaatt 975901 tttcggttcg gcaaacggtc ataaacgacg ttcggcaatg gaacgatttt tttctcccag 975961 ccgttttccc tgtaaaggag gccttcaatc gtgccttcct cccaattgat ttggtgcgcg 976021 ccaaaaacga agcagtagcc cccggcttgc tcgtgtaacg tgacaagttt agaaaaaaag 976081 agggaacgat ccttaaatgg gcgttcaaga gatacagtaa accctgccgt aaagatgccg 976141 actaacggcc cgatatgcac tgtatgatca tgaatcagta tatctgccct gcttcggtgg 976201 ggaagcaaaa gctcatgaaa cagattttca gagagaagca cggtttgttc cagatgccgt 976261 ctgtaagcaa cgtggcatct gacaaccttc gttccgaatg cggcatgcaa aagtccgtct 976321 tgcttcagcg aagagggcag aaacagggtg ttttcactgg ttttgtctat gccgatcaaa 976381 aaccgtttag gattcacgcg gaagaactcc tttctggctt tgctcagaaa acagatattg 976441 gcagcgtttt aggggacaag tgtacagctg ttctttttgc tcgggagaga cacgcaggat 976501 tgacttcctg cctggtttgg aattgatatc taaaatccaa attctcccgt cctttgcaag 976561 acatatatca agaccgagtt caaacaacgg cccatagcgc tcgtcaagat aatacggaac 976621 cgattgggta attgaaaaca catcatctag taaaaccact tgctgttttt tcggtatatc 976681 ttcaaaccag gagtcaaatg tcagcgcatc agatccgcct gacaaattgg ccagcagccc 976741 gtgtttgtat ccgcgtctta ctgcctttcc gactgtattc cattcacctg cttcgttttt 976801 ttccataaac agacgaatat cacaagggta ttgttcctta tcttgaatgt ttaagtaagg 976861 ctgaagcaaa tattgatgct gaagcacttt tttgcaccat gttttaaaag aagtctggtt 976921 ggaaaacgtt tttgtctgct tatcctttcc gatgtgataa gtagcagtga tgtttttctt 976981 gcccagcttc aaaagaatca cgcctctgcc tcccgcgccg aatgccggtt taaggatgca 977041 ggctttttct ttggataaaa aggagtgaat ttgttcgtag cggctcacct ttatcgtttc 977101 gggaatatag ggattgatta cagagtgctg ctgcaaatcg tgaaggacgg tccacttatc 977161 gggaagaccc cgcccgataa attccgtttt cggatatttt ttgagccact caacgattgg 977221 ttttgctttt tgggaatgtg aatccttgcc gtaaaaacag cgatcataaa tataatctgg 977281 aatcgccatt tcagtttcgt tccatgtgct gctggccgaa tgatagaccg atgctttgac 977341 acgcaaagtg tcaggtgaaa tatcaaatgg tgtaaaccgg atgaaacgta tgccgaattc 977401 gggtgctctt ttggccagtt ctgcggaata atccgcttca tgctggcggg ataaggacat 977461 aaaaccgagt gttatcatgg tgagactccc ccttttattc aaaagctgcc ggcgggtgtc 977521 cgcagcttta cactaaatac atgtaagacg aacgcagctg acggtattct actttacaga 977581 atacgattct ccaccttgcc ctattccaaa agaacaagct gattttctaa gaacaggaat 977641 ttgtctcctc gtttgctaag tgattgcatg agcctctata atacgtatag gtacataatc 977701 tatatgaaaa aagctgaagc acagatggag gaagatgaat aggaatgggt attgcaggaa 977761 cctttatttt tatgatcgtg atcggcgctg ccattggagc ggtgaccaat catttagcaa 977821 ttcaaatgct gtttaggccg tataaagcgt actatttgtt tgggaaacga gttcctttta 977881 cgcccgggct gattccaaga cggcgagatg aacttgcaaa acaaatggga ctgatggtag 977941 tcaatcatct cttaacccct gaaggcatta aaaagcggct cgtctctgat gcagccaaaa 978001 cgcaggctct tcgagtgggg gaacagctga ttcaaaagct gtcactttct gaagtgacag 978061 taaaagaagc gcttgaaaaa gccgggatga agcgccccga aaaagctgct gatgcatgga 978121 tcagcagctg gaccgatgat aagctgcatg agcttttccg ccaatacggg gaccaatcgt 978181 taaaagagct ggtgcctata gaggtgcagg aaaagcttga ggaaaaaatt ccgatgattt 978241 caggatatat attgtcacgg agtgtccgtt attttgaaag tgatgaagga aaaatccgtc 978301 ttggcaatat gattgatgac tttttaaaag agcgcggcat gcttggaagc atggtgcaat 978361 tgtttcttgg caattcaagc cttgcggatc gcgtgctgcc ggagctgctg aaattcttgc 978421 gcaatgagga aacaaataaa ttgctttctg atctcttaaa aaacgaatgg ggcaagctga 978481 gggagtatac gtttaatgaa gcagatgaaa aatggaatgc aaaggcgctc attttcagtt 978541 tgaaacgaag agtgctgcaa gcattttcga ctgccccttt cttcaacaat acgattggca 978601 cgcttaccgt ccgctatgaa tctgagctga cccagcaaat gctgccggca ctattagaca 978661 aattgcttga aggtatttcg tccaaccttg aaagtgtctt aaaacggttg cgtcttgagg 978721 aaatcgtcaa ggagcaggtg gatcagttcc cggtggagcg tcttgaagaa atggtgctgt 978781 ccatttcaaa aaaagaattt aaaatgatta cctatttggg gggccttctc ggcggaatta 978841 taggcgcgat tcaagcattg tttgtcatcc ttttttaaga agaaatggtt tttgattaat 978901 gaaaggagct ccatagtctg ttatagtgga gtggtatgtc aaacggcaat gatgaaagga 978961 gctatttaca atggctgtta atttttatga tgtagcgtat gatctggaaa atgcattacg 979021 cgggagcgaa gaattcaccc gtttaaaaaa cctttacgac gaagttaacg cagatgaatc 979081 agcgaagcgc atgttcgaaa acttccgtga tgtacagctt agactccagc aaaaacaaat 979141 ggcaggagaa gagattacac aagaagaagt gacgcaggct caaaaaacag ttgcgcttgt 979201 acagcagcac gaaaaaattt ctcagctgat ggaagcggag cagcgcatga gcatgctgat 979261 tggtgaattg aacaaaatca ttatgaagcc tttagaagag ctttacggca gtgttgaagg 979321 ctaataagca aaatcccttc ttggataaga agggattttt tattcactca gcaaacttgg 979381 aaatccaatg aatcttttac ctctccattg atgatgactg ataatgtatg aattcctttg 979441 taatgctttc tggtggttaa atccttaaag gattggattc ttgtgtatga cttcgtttcg 979501 ttttttcgta tatttgtttc tgttatttta aatactttct gatgacgctg gcctcttgct 979561 tttacaaaat caattgcgta ctcaattctt actttttgat ccctgtctga atgaatatag 979621 aaagaaaatt caaggctttc gccaataact atacgtttgg gctggcatgt taaatcatgt 979681 agttgtatcg aatcagcatt ttcataacca aaaagcgcta aggcctgttt atcacccttt 979741 tttaataagg tccgataggc gtgtttgata atccagtctg tatggggatg tgttccgtac 979801 cattgatctg cgacttttct cagtaaatga ggatgcgttt ttgatatatc attaaggttg 979861 ttggccacgc tttttcttac atataaagac tcgtcctgca tcagcttctc aaggatcggc 979921 aatacggggg aagggtccga tttcaaagcc ggtatcgatt ttccccatgg caggcggggc 979981 ctgctgcctt cgctcgcaag tcttctcacg tgttcatttt tatgctcaga ccatgcaagc 980041 aattgtgcaa tcatcttttc ttgatctaac agcaaaaaag gccttacagc aaattctgag 980101 gtcgaatatt gcgtaaagga ttccaatgcc tttattgatt cttcccaatg cgctaacccg 980161 tactgttcca cataatctgg aaataaaatt ccgctgagtc ctttaaaatg aggggctgta 980221 tcccgtaaaa ttgtgagcgc ttcaacgtat tgttttggca aagtttcgta taaagaaact 980281 gtcacgcggc gcatccgctc ttttaaagtg agttcaggcc agtcctccag ccgtaatgta 980341 tccaagaatc tgtttttgtt aaaatcagga taggatgacc ttacatgatg gatcaactga 980401 gatatcagtt cttcattata tatttctttt aaatcagcca tataaacacc gctttttcgt 980461 ttattattta tattgtatgg gaatgtacgt tctggatcaa gtgtatagtc ctaaaaatta 980521 acaactgatc ctaccacgga tatacaaaag ttggttactt tttttagtta aaaaaaccct 980581 tgtcatcgga aaggaaaact gagataataa cattgaaagc gcctacactt acctatttca 980641 aatggatacg gtcgcatatc atgccgttat atagagggga taagcaacag agagtaagtg 980701 ttcggagcgc atcattggtc aaacaagggg ttcctgatac atgatttttc gtaaatcgaa 980761 ataacgatat tagggagaat ggctgcttcg atcgtatcct atcaacaagc catacataaa 980821 gtctgctgag ccaggctttt tttgctttaa gaaaaggttg ttctaaacac agagacaggg 980881 tcatatccta tacacaagta cagtcatcaa ggagggggac atctctgtgt caaaacaatt 980941 gcttgcctta aatatagatg gagcgctgct tcggtcgaac gggaagattc atcaggcaac 981001 gaaagacgcg attgaatatg taaagaaaaa agggatttac gtcacacttg tgaccaaccg 981061 tcattttcgc tcagcacaga aaatagcgaa atcgctaaag cttgatgcca agctgatcac 981121 ccatagcggg gcatatatcg ctgagaaaat tgacgccccg ttttttgaaa aaagaatttc 981181 tgatgatcat acctttaaca ttgttcaagt gctggagagc tatcaatgca atattcggct 981241 tcttcacgaa aagtattcca tcggaaacaa gaaaaaggtg aattcgaatt tattagggaa 981301 agcactcatt catccgtctg acccgatctt ttatccagtc cagttcgttg aatcattaag 981361 cgatctcctc atggatgagc cggtgagtgc acccgtcatc gaggtgtaca cggagcacga 981421 cattcagcat gacattacag aaacgattac aaaagccttc cctgcggtgg acgtgattcg 981481 cgtaaacgat gagaaactga atatcgtccc gaagggtgtc tcgaaggaag cgggtttggc 981541 cctcgtcgct tcagagctgg gcctgagtat ggatgatgtc gtggccattg ggcatcagta 981601 tgacgatctg ccgatgatcg aacttgccgg tcttggggta gcgatgggga atgccgttcc 981661 ggaaattaag agaaaggcag attgggttac aaggtccaat gacgagcaag gtgtcgctta 981721 tatgatgaag gaatatttcc gaatgcagca gcgaaaagga tttcttgata agttccacat 981781 gaaacgtgtg taaaaaagcc gctcgcgccc tgacaggtgc ggcggctttt ttgccggatt 981841 gattttagca gtttatttct gtacactaaa gaaagttttg aatctgataa attaggtgat 981901 gaagttgcaa attaaaatag aaggcataca tgatgaccgc ctgcatcggc ctctgcaaaa 981961 tattgcaaat ttgttttatg aagagtgcga gcttgcgtat ggcggagagg agcccgcaga 982021 ttttgtcatt tctttagcgt tgtcacaaac ggatgagcat gtgacggttt ctggagaagt 982081 gaagggtact ggcataaagg aacagcatac aaaattcttt tctccagaca tgactgaaaa 982141 agaagctttt aagcaagtga aaaacacaat ttcttatgtg tatctcaatc ttcttcaggc 982201 gcatacgggc attacgcaga agtggggaat cctcacagga atccggccca caaagctgct 982261 tcataaaaaa ctgcaaagcg gaatgtccaa ggagcaagcg catgctgagt tgaaaaaaga 982321 ctatttaatt catgatgaaa aaatcatgct aatgcaggaa attgttgacc gtcagctggc 982381 ggcagtgccg gatttgtacc gagtaaagga tgaagtcagc atttatatcg gcattccgtt 982441 ctgcccgaca aaatgcgcgt attgcacatt ccctgcgtac gctatccaag gacaggcggg 982501 cagagtcggc tcattcctat ggggactgca ttacgaaatg cagaaaatcg gtgaatggct 982561 gaaggagcat gatgttaagg ttacaaccat ttactttggc ggcgggacgc cgacaagcat 982621 tacagcggag gagatggatc tgctgtatga agaaatggtc cgctccttcc cggatgtgaa 982681 aaacattcgt gagattacgg tggaggccgg tcgtcctgac acgattacag aagaaaaact 982741 cgccgtttta aacaaatatg acattgatcg gatcagcatc aatccgcaat cctacgaaaa 982801 cgaaacgcta aaggcgatcg ggcggcacca tacggttgaa gagaccattg agaaatatca 982861 tctgtcacgc cagcacggca tgaataatat taacatggac ttgattattg gtttgcctgg 982921 ggaaggcgtg aaggagttca ggcacagtct ttcagaaaca gaaaaactga tgccggaatc 982981 ccttaccgtt catactcttt catttaaacg ggcgtcagaa atgacgagaa acaagcataa 983041 gtacaaagtt gccggcaggg aagaggtttc tcaaatgatg gaagacgcgg tagcctggac 983101 gaaagagcat gggtacgtgc cttattattt ataccgccag aaaaacattc ttggaaacct 983161 tgaaaacgtc ggatactctt tgccgggaca agaaagcatc tacaacatta tgattatgga 983221 agaggtgcag acgattattg gcatcggctg cggcgctgct agtaaattta ttgatcggga 983281 tacagggaaa attacgcatt ttgcgaatcc gaaagatccg aaatcgtaca atgagcgctt 983341 cgagcactac acggacgaaa aaatcaaata tttagagcag atttttgaaa aaacgacaaa 983401 gcagcactga ttacagtgct gcttttttta tccctgtttt tttgcgggct gaacctcagg 983461 cttccattta aataccttgt tcagcaagcg gtaaattcgt tttgattcct ttgtgacaag 983521 cggtcccaaa atcgccagaa tgaggacata taatgcggca aacggcttta atgtggccga 983581 cagtccgccg gctatcccga gattcgcaac gataatcgaa aattctcccc gcgatacgat 983641 cgtcagcccg atattcgatg aagccttatg agaaagccct gcgcgtcgtc ctgccaccat 983701 tccggcgata aaatttccca gaatggtcaa aatcactgca cccaacgcaa gccaaaccgc 983761 ttcaccaagc gaaaacggat cgatgctgag gccgaagctg aaaaagaaca tcgcaccgaa 983821 gaagtcgcga aacggaacaa cgaggtgttc aatcctatcg gaatgctctg tttctgaaaa 983881 gaccaaaccg agcagcagcg cgccgattgc ttctgctaca tgaatcgtct ctgaaaaacc 983941 ggcgataaaa aagagtgctg cgaaaatgac gataataaac acttcgtttg agcgaatgtc 984001 caacagtttg ttcaacagcg gcgggagttt tcttgctgcg ataaaaaaca gcagcatata 984061 accgaaggcg atcaaaatgg acaagagtgc actccctacg gatgtcgcat cacctagtat 984121 aaggccggaa acaacggaca gatatacggc aaggaaaata tcttcaaaca tgatgatgcc 984181 gagaatcaat tcggtttccg ggttggcggt tctttttaaa tcaacgagca cttttgcgac 984241 aatcgcactt gacgagattg tgatgacgcc tgcgaggatg aggacttcca gaaaggaaaa 984301 tccggtgata aacccgtaaa gcagtccgag gctgaagtta atcaaaatat aaatcgtccc 984361 gccgaccgcg attgattttc ctgatttgat taacttcccg acagagaatt cgagtccgag 984421 atagaagagg aggaacagta cgcccattcg cccgaaaaac tcgatgattt cactgctttg 984481 aataaatgtt agatcaataa tccccatttt cggcgcgtgc ggtccaacaa gcattcccag 984541 cacaatcaga aacggaataa tcgaaaattt aattttattg gcgatcacac tggcgattgc 984601 cacaagcaca agtgcagttc cgacttcaaa tacaagatgg tccatcgggg ctcacacgcc 984661 ctctccagaa agaaaatcgt gaatcagttt cttcagatgc tttctctcac ctgagaggac 984721 aagggtgtca ttttcttcaa taatcgaatc cgctccggga tttaggagct tttcctggtt 984781 gtgtttgata atcgcaataa cagtgacatc gtaattctgg cgaacatcaa gctcaccgag 984841 tgtgcgtccg atcgatttgg cgcctttttc gaccttaaac cattcaataa taagatcgct 984901 gaaggccatt tcgatggact ccagagcttg cggtttatag accatgcccc cgagaatagc 984961 tgcaatttgc cttgcttcag aatcatccaa tgaaatattt gaaagaagct catccgggtc 985021 ccggtcatta aaccggtaaa tttcccttct tccgtcatca tgaatgataa tcgtcatttt 985081 ttcgtggctt cttgtttcga tttcaaactt tttgccgatg cccggcagat cgttttcttt 985141 aatattcaat gaaaatccct ccgaatgtag tgttggcagt atggggtgag ttacaaataa 985201 aacttgagca aattatattc ggaggtaatt agactggtat ttgacaggga cggccaaagc 985261 cttttccagc ctgtttatca gcggttcgtc aagtggtttg acagagagct gcctgacaga 985321 ctgcgccagc gggctgtact ctttgatcag ctcagccggg tgcatgctgc ccggcgatgg 985381 cgtttttgcc gattgtgttt cctgcggata tgaagacata ggcacatagc tgtcagtgct 985441 tgcttcaaac tgggaaggca gaaccacgtc cgaaggggga aagtacacca taaataaact 985501 taacagaaaa ctgatcagca atttatccat gttcctttcc tcccttctca tcaagatatc 985561 ccttcttttt cactatataa aactttatgt ttccattcaa acaatatgca tttttcagta 985621 tctattgacc ttgaaaaata aaaaggttta tttggggatg gcggggaatg tataggagaa 985681 agaaaaaagt aagcgcatac atggaggtgc ttttaatgga gtttgttcaa tatgcatgta 985741 atggggccgt tgcagagatt atcctgaatc ggcctgatgc ccatcacgcc ctgaatgaac 985801 agatgctgtc tgaattgaag gaggcagtcg aaatggcggc tgcaagcgag gcgctcatcg 985861 ttctcctgag aggaagcggg aaaggctttt cggccggcgg tgatatcagg atgatgacgt 985921 cagagcatga ccctgaccaa tttaaacggc tgatggatac gattgaggct gtcaccctga 985981 atttatatca gatgaagaaa gtgacaattg cagccattca tggtgctgct gcgggactgg 986041 gcctgagttt ggcgctttgt gcggacattg tgctcgctga aaaaaacgcc gttctcgcga 986101 tgaattttat cggcattggg cttgttccgg acggcggagg acattatttg ctgaagaaaa 986161 gaatcggtga agcaaaagcg aaaaaactga tttggagcgg aaaaaaacta tctgcctcgg 986221 aagctgccga tatggggctt cttgatggga catttgccgg agaccctgcc gaaggcgcaa 986281 gacccattat cgaaaccctg ttggcctccc ctcttttggc gatgatcgaa acgaaaggta 986341 tttttcaaag cctccaaatt gaagaactga aaaaagtgct atcccttgag cgcagcgccc 986401 aagagagaat gagaaggacc aaggatcacc aagaaggaat ccgtgccttt ttagaaaaac 986461 gggagccgaa gtttcaagcg taacagatca gccggaaagc tgatcatctg tgaaacaaaa 986521 tcagctttcc ggctgcattg actaaacgat gagtatgact atgaagctct ttttctttta 986581 agagggcttc accatgcgtt tttgccgctt cttcatgttc tgcctcgaat tgctcgttta 986641 ccagcgtgtt ccccgaagga tcaaatacgg taaggaaata atcagccatc aggtttctcc 986701 tccattttaa ggtttatcag tctttcttca tttatattct aaaaaggaaa tcaaaatcct 986761 ttattatgct ttatccaaaa ttagtatata atgggtcagg gaaggaggag attcagtgct 986821 tacaattgat cacgtaacga agacatttgg agattataaa gccgttgacg gattggactt 986881 agatattccg gaacagcaaa tgttcggtct attaggcgca aacggagcgg gaaaaacaac 986941 aacgtttcgc atgatcctag gattattaag cattacggag ggctcaatca gctggaaggg 987001 ccgtcctgtg aattatcata tcagcaacaa aatcggttat ttgccggaag agcggggcct 987061 ttatccgaaa atgaaggtaa gggatcagct cgtctatctt gccagattaa aagggatgga 987121 gaagcgagag gctgtaaaag agctcgggac atggcttgaa cgcttcaata ttacagatta 987181 cgagaataag aaggtggaag agctttcgaa ggggaatcag cagaaaatcc aattcatttc 987241 ggcagttttg cataagccgg agctcctgat tcttgatgaa ccattcagcg gcttggaccc 987301 tgtcaatgtt gagctgctaa aagaggccgt gatctcgctg aaaaacagcg gtgtttctat 987361 tttattttca agccatcgga tggaacatgt ggaggagctt tgtgagaacc tttgcatatt 987421 gcagaaagga aaaccggttg tacaaggcaa gctgaaggag atcaagcgtt ctttcggtaa 987481 aaagaatgtt accattcact ccgatgacga tctgcgcttt ttgcagtccc atgaaggcat 987541 tcttcaatgg aaggaaacgg cagacggcgt caagctgcag attgccaatg aagacatttc 987601 tcaagagatt tttgcgatgc tccaaggaaa agggtttatc agaaagtttg agcttgaaga 987661 gccgtcactg catgatattt ttatagaaaa ggtgggggcc gtctatgaat aaattttgga 987721 tcatgctttc tcatacatac aaaaataaga ttatggcaaa atcctttatt atttcgactg 987781 tcatcacggt gctgcttgtt ttagttgtaa cgaatctgga gtcgatcatt tctttgtttc 987841 aaggtgacga tgcgaaagaa aaaatcgccg ttgttgatga aacaaacgaa ttatatccgg 987901 ttttttctaa gcagctgaaa gcggtggata cagacggcga tcttgatgtg aagctgtcga 987961 agcaatcgga ggatgaggtc acaaagcaag tcaaagatga atcactcgat ggcatgctca 988021 tcatcaaacg agatgaaaaa gggaccattt caggaacata taaagcgtta acgatttctg 988081 atgaaagcac gtatcaaaca ctgcagcagg cgctgacgca aaccaaaaca gctgtcggaa 988141 cagcggagct cggcgtgtcg caggaaacga ttagcagcct ttatgcgcct gttactgtgg 988201 ggcagaaggc gctgaaagaa ggggcaaagt ctgaggaaga gcttggccag acggtagggc 988261 ttgtttacat tatgctgttc gtcatttatt tctcggtgat tatgtatgcc agcatgatag 988321 cgatggaggt cgcaaccgaa aaatcttcgc gagttatgga aatcctgatc tcaagtatgc 988381 cgccgatcca gcaaatgttt gcaaagctgc ttggtatcgg gcttgtcggg atcacacagc 988441 ttgctattat tataggagcc ggctctctgt cgcttaagct gaaccaaaag agcgaaacgg 988501 cttcatctgt cggcggattc cttaatttga ccgacgtatc tgcaaccact gtcatctatg 988561 ctgtcatttt ctttttgctc ggatactttt tgtacgcgac acttgccgcg tttctcggca 988621 gtgtcgtcag cagaatagag gacgtgcagc aaacgatcac gccgatgacg cttttggttg 988681 tcgccggttt tatgatcgcg atgttcggtt tgaatgcgcc tgacgcagga tttattacgg 988741 taacttcgtt tattccgttc tttacgccaa tgattatgtt cctgcgcgtc ggcatgcttg 988801 atattccgtt ctggcaggcg gctgtcggaa tcggaatcac actgctcacc attgtcatac 988861 tggccgttat cggcgccaga atttataaag gcggtgtatt aatttacggc aattcaagcg 988921 cgttcaaagc gatcaaacaa gcgctacgtt tagcgaaaaa ctgattggaa aacagcctgg 988981 ggattctcag gctgtttctt tattgacaga acgtgcattc gcaagaattc ggtgctaaaa 989041 taagggtact tcatcctgga aaggagcaga atgttgactg atctaacctt tattcatgcg 989101 gcagatcttc atcttgacag cccgttttac gggatatcgc atctgccgga gccgattttt 989161 gcccggatta aagaaagcac gtttgcaagc gtgagacata tgatagacgc cgcagtgaga 989221 gagcacgttg atttcatttt gcttgcggga gatctgtttg atgaagccaa tcgaagctta 989281 aaggctcagc tctttttgaa aaaacagttt gaaagactca gagagtgcgg aatttcggta 989341 tacgtcatct ttgggaatca cgatcatctt ggcggggagt ggacgccgat tgaatggcct 989401 gagaatgtcc atattttttc gtccgctgtt ccagaagaaa aatcgttttt taaagaaggc 989461 aggcgcatag caagcattta cggcttcagc tatcaagcca gagcattgat ggaaaaccaa 989521 gccgcccgct atcggagatc aactgacgca ccgtttcata tcggcatgct ccacggcacg 989581 ctgtcaggat ctgaaggaca cgatccgtat tgcccgttta cacatgacga cctcgtgaaa 989641 agcgggatgg attattgggc gcttggccat atacataaac gccaggttct atctgccgag 989701 catccggcag tcatttaccc gggaaacacg caagcacgcc atataaagga gacgggagat 989761 aaaggctatt atctcgttca tgtgacaaac ggagatatat cttatgaatt tcagagagcg 989821 catgatgtcc tgtgggaaaa agcggcggtt gatgtgacgg aggcaaagaa tatgacagcc 989881 ctcttccaaa tggtggagga cacgttttcg aagctgcgga aaaaggggag ccctgtttgt 989941 gtaaggcttg ttttacaagg gacggcgccg gaatggctgc tggaggcgcc aaaaggcacc 990001 ttggatgagt ttcttgaagc tcttcaggaa caagaagcgg aagaggaacg tttcgtttgg 990061 cctcttagat tggacgatga gacagaaaac gaagcaaacc taacaaacct tgatcctttt 990121 tttggcggtt tatttgaaga cattgatcgc agcgatctgt cagacgtgct ggaagggctt 990181 gagcggcatc cagtgtatag aaggcacgcg gaccggttta gccaagagga ggtaaaggaa 990241 ataaaagagc aggcacagat aatattgaaa agacagctta aggtgcttga tacatgaggc 990301 ggtgacagct ttgcgaatta tatctttaca tatctaccaa tacggaaaat tttccaatcg 990361 gacctttgac ttttccgcct ctcctgtcca agtcatctac ggattaaatg aggcaggaaa 990421 aacgacgatg atgtcattca ttgaaagcat gctgttcggt tttccgaaaa cgaaaaagta 990481 tgaaccgaaa acaggcggtg tctacggcgg tgttcttgaa gctgaacatc ctgagtatgg 990541 ggtgctgaag atcgaacgga cgaaagggac tgccgaaaaa ctaagcgtgt acacagaaaa 990601 gggcgaagta aagcagggag atgttttaaa gcagctgttc cagggcacag acaggtcgtt 990661 gtacaaagcc atatattcgt tcgacgtatt cgggctgcag gaaattcacg cctttaatcg 990721 ggacaagata ggggaatttt tgctcttttc cagcttgttt ggtgctgaag ccgtatcaaa 990781 gcttgattca aggctgacga aggaaagcga aaggctctat aaaccaaatg ggcgaaaccc 990841 tcaattgaat caggagctgg aaacgcttaa gcagctggca gttaagctaa aacaggctga 990901 agcagaggaa gcgggctatc atcagcttct cgaggaaaaa cgaacgcttg aagcccgcct 990961 tgcagccgcg gaaaccgaat tgaaagagac ggcgggacat atccgaatga ttgagggagc 991021 gattgagcga aagccgctgc taaatgaaaa agcgacactc gaacaggtga ttgcagaatt 991081 tccggaacac gcaggacaat ttcctgctga cggactgcat cagctggaaa aatatgaatc 991141 ccatcttcac ccgaaatcag cacagcttga ggcgcttcgg gtgaagatgg cggagttgga 991201 caaacagagg caaaagctta tccccgataa agaactattg gcgaaagaaa cgctgataca 991261 agagctttcg gcagcgtttc atatgtacca atcctgggga gaacagctgg cagccattca 991321 ggcacagctg cgccagacgt ctgcgcagac agcggcaggg ctggaacagc tcaataaaac 991381 ggatgaaaat gagctcctga atatgaacac ctcatatgat tatgaatggc agcttcagca 991441 agcggtgcag caatatgtac aggcaagaga cagaaaacgg cagcttgacg agacgtttga 991501 acttgcccgg caagagctgg aagacgcgga aaaggccgtt cgtgccgctt cgtccgcgat 991561 tcttgaaaac agccaaagaa aagataaaga agcagctctt agagcatatg atgaaacaca 991621 ggggcagcac caagagcaag cgaagctcag agaacagcta acgttttttg aaagacagca 991681 ggctaaacag aaaaagactg tcattgcagc tggtatgttg ttcatcgttc tcttttctct 991741 gctgcagcaa tggattcccg ccataagttt cggcgctgca cttattgtgt attggcttgt 991801 ttcaggaaag tcgtcttctc gaaacagccg agagacaaga cagcccatga cggatatttc 991861 accagcagaa gctgaaatgc ttagagaagc gttatgggag gatgaccgca ataagcagca 991921 ccttctcaca cagcgtgcag cgctccagca aaaagaggcg gcgtatgaaa gggtcatcca 991981 gcagtttgaa cagtgggaag ccgaaatggc gccgtccttt acacaggttg agcgttttat 992041 gaatgagctc ggatttaagg aagatccatc atttttgctt gatgcataca gcttaatgaa 992101 ggatgttaaa aaagaagtga agaaaaagca tgagctgacc atagaagcag gcaggctgaa 992161 aaagcaccgg agaacattcg aagaacgcgt cagtatgctt cttcccgtga atcagagtca 992221 ggatatctcc atttcggacg cccttcacac attgcggaaa aacattgaac gtgaaaaaga 992281 aattgagaag caaaaaaagg aaattgaaac agatattcat tatacaaagg aacagatgct 992341 tgaacttgag caagaaatac agtatttcca cgcacagatt gaacagttat ttgccgcggc 992401 tgctgcaaaa gacagagatg cgttttttgc catagccgcc atcagcaggc aattgaagga 992461 tacggagaac aagcttcatc acgtaaacgc acagcttcaa ggcgggtacc cggaggaact 992521 tgaactggcg gattccaata cgctttctga attgaaagat aagcaatttg ttgagaatga 992581 aagaaaagag cggctgactg aggagatcga gcagctccgc agccaaatcg cactgctctc 992641 agtcaaacag gaacaattag aggcttcggg aatggtctca gacctcaagc ttcaaaccga 992701 aatgcaaaaa gaacgtgtga aagaaacggc taaaaaatgg gcctccatac aaatggtcaa 992761 acaggtgatc agaaacaaat tggagcggca taaaaaaatc gagcttccgc gccttctgga 992821 gacggcagga gaatttttcc gtcctctgac tgacggaaac taccaaacca tttatttttc 992881 cgaaacggat gattcgatca tggttatgca tcgcgatggc actgtctatc atgcggaaga 992941 gctgtcacaa gggacgtgtg aacagctgta tacagcgatc cgctttgctt tggccgttac 993001 gcgccagggt gagtcaaagc ttccgttcca gcttgacgac agttttgttc attttgatca 993061 ggaaaggctg aaacgtgtat tacatgttct gtatgattta tctgaaggcg gtaggcagat 993121 tttgtatttt acatgccatg agcacgtaaa agatgcattt catagcagcc aaatcatcca 993181 tttggtgtca taaaagaggt tctatagctg aaaatcggta tgtgatatac tggtattatg 993241 taagatacgg agggagcttt aatagaatgg ctaaagggat tatgctacat gaggttggcg 993301 aacaggtgga ccagtatcta ttgattaaat cctcgacgaa agggattgca agcaatggaa 993361 aaccgtttct gacgctgatg ctgcaagacc agtcaggcga tattgaagcg aagctgtggg 993421 atgccaagca aagtgatgaa gtgacctatg cgccgcagac gattgtcaag gtcgtcggcg 993481 atgttcacca ttatcgcgga cgcacccagc tgaagctaag aaatatcaga ccggtaagcg 993541 agcaagaaaa cgtcaatatt gatgattttt tagaaaccgc gccgattccg aaaaatgaaa 993601 tgatggatac catcactcaa tatatatttg aaatgaaaaa tccgaatatc cagcgaatca 993661 caaggttttt ggttaaaaaa cacgaagctg agtttatgga ttatccggcg gctacgaaaa 993721 accaccatga gtttgtctca ggtttggcgt atcatgttgt ctctatgctg aacctggcga 993781 aagcaatagc agatttatat ccttctcttg atcgtgatct gctttacgcc ggtgttatcc 993841 tgcatgatct tggaaaagtg aaggagctgt ccggccctgt ttccacttca tatacggttg 993901 aaggcaattt gctcggccat atttccatca tggtgacaga gctttcaaaa gcggctgagg 993961 agcttcaaat cgattctgaa gaggtgttaa ttcttcagca tttgattttg agtcaccacg 994021 gcaaagcaga atggggcagc ccgaaaccgc ctatggtgaa agaagcggaa attcttcact 994081 atatagacaa tctggatgca aaaatgaata tgatggacag agcgcttgag cgcgtgaagc 994141 cgggcgagta tactgaacgt gtatttgcac tggaaaaccg ttccttttat aaaccgacat 994201 ttcataaata acttaaaaag gactgatgct gacatattca gctcagtcct ttttgatgcg 994261 tctttcccgc acataactcg tctcattccc gcatatggtt aagaataaag aatctatgca 994321 aagggggagg agcccgtgtt attttttccg tggtgggtgt atctttgtat tgtaggcatc 994381 attttcagcg catataaact tgtggcggca gccaaagagg aagaaaaagt agaccaggct 994441 tttattgaaa aagaaggaca gatttatatg gagaggatgg aaaaggagcg agaacgccgc 994501 agttctcagc agcatgaaga agaaaatcaa aaccattcca tcgcataaaa aaagctgtgc 994561 ggctcaatga gccgcacagc tttttttatt atttagaatt gcttgaagat gaagaagtgc 994621 tgttgcttgt tgaagatgta ttaaatgtgt ctttcagatc tttatctttt acttcgatgt 994681 cagccttctt catgactttt tgaacagctt cctgaacagc tgcgttgtca tttaattttt 994741 gttcaagcac ttcagatttc agttcttttt tcatatcatc atatttgccg cgttcttctg 994801 tctttttaat gatatggtag ccgtattgcg ttttgacagg atcactgact tcacctgttt 994861 ttaatttgaa tgcagctttg ctgaatgttt cgtccatttg gccttctttt gcgaaccagc 994921 caagatcccc gccttttgaa gcagagctgt ctgttgagta ttctttcgca aggtcttcaa 994981 acttctcgcc ttttttcagc tttttctcta cttcttcagc tgtcttttta tcagcaacaa 995041 ggatgtggct tgcacggatt ttgcctttta agccttccca gtactctttg atatcggcgt 995101 ctgttacttt gatgttatct ttagccgctt tttgtgtcag caattcatat tttacttgtt 995161 ctttcaggta atctttgcca tattgctttt cgagggcagt atattgatcg ccaagctgcg 995221 ttttgtattc tttcagcttg ttgtcaattt ctttatccga aactttatac ttcttgtcca 995281 atactttttc ttgcactagc tgtgtcagta cgcttgcgcc agctgttttc ttcatgtttg 995341 tgtaaagctc gccttttgtg acatcgcctg cgtctgtttt tgcgataact tctttgtcgc 995401 cgctgctgca agcactgaga gcgaggatgc ttgtagcagt gatagctgct attgcgattt 995461 tcttcattgt tttcaaacac tcctaatcat tccaaattaa attacctatg cgtatcataa 995521 catattgtgg ctttctgtaa aaagatttta aataaagggc attcgtctag tcaaactttt 995581 gctgatgaca tacttatata ttgatcaaga aaaggaggta tgtaacatga gcggaggata 995641 ctctaacgga ttcgcgttgc tcgtagtact gttcattttg cttatcatcg taggtgcagc 995701 ttacatctac taagcagccc gaggatcgct tgcaacataa gcgatccttt attttcacta 995761 gcgcctaatc gtttcaaaca tgaattgcat aacatgtaat tggtaaataa agcttattac 995821 aggaggtgct atttaagatg ggtgaagtat ttgcaggcgg attcgcttta ttggttgtgt 995881 tatttatttt attgattatc atcggcgctt cttggctgta ctaatcaaca taaaaaagca 995941 tagctgctta atcagcagct atgctttctt tcgtatttac actgtaaagg agatctccac 996001 aaacgaagag atcagtaaaa ttaatataga tacattaata aatcggaata ccttatcttg 996061 ccgctcttca ggaatctctc tgacaaggca taatgtattg gtgagcctgt ttatgaaata 996121 taaaataaac acggcagcca cgataaaata gaataaaatg atgggagatt ccccctctct 996181 ctgaactgtc ccatattaca ttaccaaata tttattaaaa aagatagaat gcaaattgaa 996241 aaatcgccac cagcaccagg gtttgactac ttttcaacaa gaatatccaa gccgtcagct 996301 tcctgatcaa taaaagcggt tttcggtgct tttatcagct tgagagccag caggaaatca 996361 ggcagacagt agccggcgtg aatgcccgag atcatgcaaa aataatgagc gtgattcgga 996421 aatgccagtg ctgcgtaaaa caataccggt gtaatcagca agaacgggct gacgagtgaa 996481 atcagcattg ttgtttttgg tatacgtttc catgtgcgca tgcgcaatat gtaaaacttt 996541 ttttctattt ttcttttttt gcagatgatt ggcaggacat ggatgacttt atgtacaaat 996601 aaaataacga cgagcaaacc gccgaataaa gatacatatt catcgcttaa gcttgtgcca 996661 ggccgcagca gctcaaaagc taaaaaggta gatataaaaa ccaaaatcat aaaacataca 996721 gcagttaata ttatgcgaac ggcgccataa tccttcatga gatttatggt cttccagcaa 996781 ttcatcaaag tcatccttcc atacatcttg aatagaatct caaaataatt tactcctccc 996841 aagagaaaaa atcaatgctt ttttaagaaa aaatatcatc cggcaggtat ttttttgaaa 996901 caagcaaaca aactgcgaaa tatggggtta gaactttctt ctcagtgaat tatcagctaa 996961 aataagatta aagatagaaa gaagtggtgt ggatggattc gatggatcat cgcattgagc 997021 gattagaata ttacatacaa ttattagtga aaacagtaga tatggacagg taccccttct 997081 atgcgcttct cattgataaa gggctgagca aggaagaagg ggaagcggtt atgaggatat 997141 gcgacgaatt gtcggaagag ctggcaacac aaaaagcgca aggatttgta acctttgata 997201 agctccttgc gctttttgcc ggacagctga atgaaaaatt agatgttcat gaaacaattt 997261 ttgccctgta tgagcagggg ctttatcaag agctgatgga agtctttatc gacatcatga 997321 agcattttga ttaactgttt acaggttcga gctcttcagc cggttcatcc gccgcactgt 997381 cctttgcttt tttcttcaat tttccgttta cgctttcaaa gtcattgtca atattggtga 997441 gtgacgtttc gaaaatttcc ataaaatcat cgccgtagat atggcgtatc atacacatca 997501 tttctgccac ttcaggaaat tttccgaata aatgatataa aggctgtgac cctttaaaaa 997561 cagcgttgcg tgtcggatca aattcctcaa gcaagctcca gaatacctcg gtaccttcct 997621 cagtcaattg gacatatgtg ttccgtttat cattcagccg tttggagaac cttaaatatc 997681 cccgttcttc cagctttttt gaaaagttga atgcggttga tacgtgcatg accccgaatt 997741 tcgcgatttc agaaatggaa gctccattca attgatacgc aatccataaa atatgatgct 997801 cattaatatt caggtcatac ggtttgagcc attgctgcca atccttctcg atcgatttcc 997861 aaagagcctt gctaagctga gccattttct gggtgaaaac cagagcttct ttcacatcat 997921 agggcggttc cactcgattc attacgtcac ctgcttctct ttttcttttt ctctattatg 997981 ccaataaaat aaagattaat aaagatgaaa atgtaagaat tttttaataa attcacaaac 998041 cattgcgacg aaagggtttt tcggccaaaa aaaatacggg tccaattttg gcccgcattt 998101 ttttcttttg aataggatat tagttttgta aggttttctc cagctgtctg attttctctt 998161 cgatatcggc aatttctttt tgcagatcct gctggtgagg cttgatctct tcctgccatt 998221 ttttaattga tgtttggagc tcgccgccca cgtctttaat aacatccgtg ctttcttttg 998281 ccgctttgat cagctggtct tttaatgcaa gcccgtctga ctttaagcgt ttgattgttt 998341 cttcaaaaga atcataattg gttttcattt tttcacgcag ctgctttcct gaggaaggtg 998401 cagtaagaag aaccgctgct cctccgatga tgccgcctac gaatagtcct gttaatagag 998461 aacgtccgct cgccattaca atcaccccgt ctttttcttc aaaataggat tcattcagca 998521 tttttcattt ttgttgaaag cctgaacttc tatacatagc ttgctttatt ttagcatatt 998581 ttttaagtga aaaggaggga gaaggttgtc tgtctttttg attgtattat cctgcatcac 998641 ccttgccttc gcttcaggcg ctgtttacta tatcaaactt ctcagccagg ctgcttctta 998701 tccgcccaag agggttatcc ggcagaaagc gcttgtttgt tcaaccggaa ccgcctttac 998761 actatgtctt atctttttca caaaactcct cgcttaaaac atgctgacat gctgcgggcg 998821 ctctgttcaa aaaaacctct cccggaagcg gaagaggttt tgtgtgacaa ttatttagca 998881 gcttccataa agcttgaacg ccttaaaatg gtttgcacaa tcggataaat aatgatcatt 998941 gagattgtat tcagcacagc ggccggcaga acaacagccg cgaacaatgc ggcgaaaccg 999001 cccggtaaac cgacgatcaa taaagctgac gatagaaaca caattcctga taagatggtc 999061 ccgatcactg tcagcacagc ggctgcacct gttttccggc tctttctgaa caagagaaac 999121 agggagaaga acagaaacgc tgatacgggt ttatcaatga tgttagggat ctgtccggct 999181 ggaaacgcgg ttgtaagcgc ggaaatgatt ccggtcacga tcccgatgac gagtacattt 999241 tgcacccgcg ggaacagcag aatgcccatg aacatcatga tcagcatcat atctggtttc 999301 atgccgccta aaaagggcgg aataatggaa tgaagcgctg cgccgattgc ggcaaacaga 999361 gccataatga ctaactcttt tgttttcata actatgctct cctctgctaa gctttttgcc 999421 ctccaataat atgctcatca tttattgcga aggctttaca gaatgtgtta tgcaaacagt 999481 ataccaaacg gacggtttgc atagccagac tttttactca ttttcctgct ggaatttctt 999541 catgaacgca gctaattttt cacagtcttc gagagagacc gcgttataaa tagaagcgcg 999601 gcagcctccc accgaacggt gtccgccaag gccgatcatc ttcgcatctt ttgctttctg 999661 aacgaatgtt ttcgttaatt cgtcatcccg aagcgtgaat gtgacattca tgcgtgagcg 999721 gctgtctttt ctggcatgtc ctttatagaa gccgttgctt tcatcaatac agctgtagag 999781 aacctgcgct ttttgttcat tgcgctgttc aacagcttcc acaccgccgt tttccttgag 999841 ccattccaga acgaggctca gcatataaat cgcaaatgtc ggcggagtgt tgtagagtga 999901 atccgctttg acatgcgtgg aatatttcaa gatttttggg acgttcgcat tttcattttg 999961 cagccagctt tttttcatga tgactacagt cacgccggaa gggccgaggt tcttttgggc 1000021 gcctccgtag atcacatcaa atttggacac atcgattttt ctgcttaaaa tatcgctgga 1000081 catgtcggct acgagcggaa ttggagaatt cggaaactcc tgccactgag tgccgaaaat 1000141 tgtattgttg gatgtgatat gtaaatatgc gccgtctttt acatccgtaa ggtcaacctc 1000201 tggaatataa ctgtaattgt ctgtttcact tgtagcggtg atagacgtgt tcccgaacag 1000261 tttcgtttct gccagtgctt tttcagacca agcgccggtc atcacaaaat gtgcggtttt 1000321 ttcaggtgtt aaaaagttca tcggaagcat tgagaattga aggcttgccc cgccttgaag 1000381 aaacaagata tcgtaatctt ccggaatgcc catcagttcg attaagaggc ttttcgcttt 1000441 ttggtgcacc gcttcatact ctttgctgcg gtgggaaagc tccataacag acatgccgga 1000501 ttcgttaaaa tcaataaatt ctttctgtgc tttttgcaga acttccagtg gcagcgctgc 1000561 aggacctgcg ttaaaattcg ttgtacgttc cattatgatc tctccctgtt ttccacgtta 1000621 atgtataaaa taatacaatt atcctatcac aaaaattcag ttttttgata aaaaattaga 1000681 attatcaaaa gaaattgacg gatgtttgcg aaatgttcac aaaataaaat aacctcatct 1000741 tatgatgagg ccaggcgttt tgcgatagag gaagagatgt tctgcagatc ctccggttta 1000801 taatcatcag catgcgtttt ccaaaccgct ccgaatccat ctccttttcc gtagcgaggg 1000861 ataatatgca tatggtagtg gaacacagat tgtccagctt tttcgccgtt attgttcagc 1000921 gtatttaagc cgatcggttc aaattcatcc cggatagcgc gggcgatttt tggaacagca 1000981 tggaaatatt gttttgctaa ttcatctgta aattcatata cattctcaat atgtgttttc 1001041 ggaatgacaa gcgtatggcc ttttgtcact tggctgatat caagaaaggc aagtacatgt 1001101 tcatcttcat acaccttcgc tgatggaatg tcgccggcaa taattttaca aaagatacaa 1001161 ttctctgcac aatgcatgag ggttcctcct tatgaaattg tttagtatgt atacattcat 1001221 cgtaccacag aaatgcagaa aatagaaaac aggatgaacg gcgagcgttc accctgaatg 1001281 cagaggaaga gcttatatga agaaaatgtg ttatgccttt ggtaagcacc tcatttgtca 1001341 ataaaatgaa gacttgttta atgcctaacg attcctgcga taaacacctc atttgacaat 1001401 ttgcttcata catgaagaat tcatcaattc agtgaagaga aatggtttga gcattggaca 1001461 tgtttatttt ctatccaact gtttctaaga cgtctttgac aaacacctca tttttcagtt 1001521 gatatgcttt tcctctacaa cttttatgat gtccagaacc ctgtctcttt atgacagcaa 1001581 attcatcatt tgttaaaagg gaattgtttc aaatcaggcc ttgtttttgg tactatgaag 1001641 aaaaacacta taaggggaga aactatgtct ctgctatcgg taaaagactt gaccggcgga 1001701 tatacaagga atccggtttt aaaaaacgta tcattcaccc ttgaaccgaa tcaaattgtc 1001761 ggcttaatcg ggctgaatgg tgctggtaaa agtacaacaa tcagacacat catcgggctg 1001821 atggacccgc ataaaggttc aatcgaatta aacggtaaaa cgtttgctga ggatccggaa 1001881 ggctaccgtt cacaatttac ctatatacct gaaacacctg ttttatacga agaattgacg 1001941 ctgatggagc atcttgaact aacagccatg gcatatggac tgtcaaaaga aacgatggag 1002001 aaaaggctgc ctccgctact aaaggaattc cgaatggaaa agaggctgaa gtggttcccg 1002061 gcccattttt ctaaaggaat gaagcagaag gttatgatta tgtgcgcatt tttggcagag 1002121 cctgcgctct acattattga tgagcctttt ctagggcttg atccgcttgc cattaacgcg 1002181 ctgcttgaac ggatgaatga agcgaaaaaa ggcggggcga gcgtgctgat gtcaacacac 1002241 attttggcaa cggcagaacg ctattgcgat tcgtttatta ttttacataa cggcgaggtg 1002301 cgggcgcgcg gcacgctgtc agagctcaga gagcagtttg gaatgaagga cgcggcgctg 1002361 gacgatttgt atcttgagct tacaaaggaa gacgctggcc atgaataata tgcttgatat 1002421 ttggcagtcg cggctgcagg agcatatcaa agaaacaaga acatacatga aatatatgct 1002481 caacgatcac ctcgtcattg ttttgatttt ttttctagcg ggcgctgcaa gctggtacag 1002541 caaatggata cgggacattc ccgctcactt tccgtccttt tgggtgatgg ccgtgctgtt 1002601 ttcgctcgta ttgacaagct cttatgtgcg aacgcttttg aaggaggctg accttgtttt 1002661 cttattgcct cttgaagcaa aaatggagcc ttacttgaag caggcgtttg tctacagcta 1002721 tgtgtctcag ctgtttccgc tgattgcgct gagcatcgtt gcgatgccgc tttatttcgc 1002781 agtcactccg ggagcttcgc tcgtatcgta tgccgcggtc tttgtccaac tgttgctgct 1002841 gaaagcgtgg aatcaggtaa tggaatggcg aacgactttc caaaacgacc gcagcatgaa 1002901 acggatggac gtcatcattc gctttgcggc gaatacactc gttctttatt ttgttttcca 1002961 atctgtttat atgtatgcgc ttctcgtcta tgtcattatg gctgttcttt atctgtatat 1003021 gtcttccgca gcaaaacgga aaacatttaa atgggagagc catattgagt ccgaattgag 1003081 acgaaagcag cgtttctatc ggattgccaa cctgtttact gatgtgccgc atttgcgaaa 1003141 gcaagccaaa cgcagagctt atctcgactt tttgctgcgg cttgtgccgt ttgaacagcg 1003201 caaaacattt gcctatatgt tcacccgcgc ctttttgcgt tcgagcgatt atttgggcat 1003261 tcttgtcaga ttaacgatcg ttttcgcgct gatcattatg tatgtctcag ccagcccgct 1003321 gattgccgcg gttttgactg tgtttgccat tttcattacg ggcattcagc ttctgccgct 1003381 cttcggtcac tttgaccatc tggcgcttca agagctgtac cctgtgcaaa aagaaacaaa 1003441 gctgaaaagc tatttctctc tattaaaaac tgcacttagt attcaagcgc tgctgatgtc 1003501 tgttgcatct gcctatgcag ccggcttgac cggttttctg tacgcgctga tcggttctgc 1003561 cgttctgatt tttgttgttt tgcctgctta tatgacgacc aggctgaaaa agcacggaaa 1003621 gctgtgaact gaaaagaggt aatcaaatga cagataatca gctgctgatg caggaagctt 1003681 tggaatggaa aatgcatttt ttgcgaaagg attccatgtt tgaacgcttt tcgaagcgtg 1003741 tccagacgaa ggtgaatgaa cggattcctg aaaaaatcca tacggtcgtc accgagagtg 1003801 tgaaaaaaat ggtagaagcg acaatggccg gctctaatat catcacctat aaaaaggata 1003861 caagtgcact gtcgctcagt gaaaaaaacg aattggcgaa aaaaacgatt gtttcttatc 1003921 aaaaagtggc agctgctgag ggagtcggca ccggagcggg cggcattttt ttaagcattg 1003981 ctgattttcc gctgctgctt tcaattaaga tgaagtgttt atttaccttg tcttccattt 1004041 acggctttga tgtcaaggat gcacaagaaa ggatattttt gctgctcgtg tttcagcttg 1004101 cgttttcgag tgatgatggc cgtaagtcgc ttttttctgt catcgaaaat tgggagacgg 1004161 agaaaaagag catcgactgg agagtgttcc agcaggaata tcgcgattat atcgacgtcg 1004221 tgaagctttt tcagcttttg ccgggcgtag gagcggcagt cggcggaatt gccaattata 1004281 agctgcttgc tcagcttgga gaaacggcaa gacatgtttt tcatctgagg atattaaagg 1004341 aaacagccgg agaataaaca ctccggctgt ttttttatag ctgatgatag gtgatcgcag 1004401 cgccggcaag gaccttggcc gctgtcagca tggctttttc gttgatatca aatttcggat 1004461 ggtggtggga atagactcgc tctggctgtt cgggagcggc gcctgtaaag aaaaaagtgc 1004521 ccttcacgtt ttgtaagtaa taagcaaaat cctcgccgcc catttgtggt tcaccgtcaa 1004581 tgacctgctg aacgccctcg gtattctttg cggtgctcac caagtggttc gtttctgcag 1004641 gatggttcac aaccgctgga taaccctgtt cataggtgta ctcataggac gcgccgtgca 1004701 tgctgcatat tccttttaca accgcttcaa tttctttctc cagaatgtcc cggacatttt 1004761 catcaaaaga acgcgctgtg ccgatgagta ctgcttggtc tgcgatgaca ttaaacggat 1004821 tgtcggcgat gaaggagcct gtcgaaatga cggcggattg aatcggattg actttgcggc 1004881 tgacaatgtg ctgcaaagag gaaacgattt gcgaaccgat taggacggcg tctttagtat 1004941 catgcggatg agcgccgtgg ccgccctttc cgaagacttt aatcgtaaat cggtctgccg 1005001 ccgccattac ggcgccgggg cggcagagaa tagttccgag cggctcagtt gcccaaagat 1005061 gagtgccgaa tatcacatcc gtgttttcga gacatccgtc atcaatcatt ggctttgcgc 1005121 ctccaggata atattcttct gcatgctggt ggatcatcac aaatgttccc ttcagttcat 1005181 gtctgttttg gtgaaggacc ttggccactg cgagaagagc tgcggtgtgg ccgtcgtggc 1005241 cgcatgcatg catgacacca ggcactttgg aggcgtaagg gacatctttt tcatcttgaa 1005301 tggggagagc gtcaaagtcg gccctcaaag cgactgtagg gccgggttcg cttccttcta 1005361 tatttgctaa aacccctcta ccgccaacgt ttgtgcggat tgggactcct aacgattcat 1005421 aataggaagc aataaatgcg gcggtttttt cttcttgaaa tgagagctca ggatacatat 1005481 gaaaatggcg cctgatctca accatttctt caaaacagcc gtcgagctgt ttgtttatct 1005541 ctttctgcag tgtggatatg gacaaagccg cttccccctt ttctatgctt ttccatgatt 1005601 gtatagaaaa agtctgaata tttcaactca tgctgtttta aagcatcatc acagctgcga 1005661 gggttgtcac caaaaggcca atcgcgacgg gaatgaagtt ttttctggca agctcaaaag 1005721 gatcaacttt gcaaatggcc gcggcgggaa tcaaagccca tgggaccagt gttcctccgc 1005781 ccacccagat ggcagagatt tgtccgagcg cggtcagaat agcgggatcg gcatggagag 1005841 cggacgaaaa gagctttgcg atggagccgg cgagagaaat gccagaaaat cctgagccgt 1005901 caaggcctgt tatggctcca gcggcagtta atgcagtggc ggcaagctcc tttgacatag 1005961 gcatcatatg ggataaagca atgccaagat cgttgacaat gccgtgggaa cctttaggga 1006021 gtgaagtgcc cagtatgctt tcatagcctg agtcgccaag ataaaagaaa gcggcaatcg 1006081 ggatgacggg gccgaaaacc ttaaaaccga acttaaatcc gtcaataaaa tagccggtga 1006141 ttttttcaag ccctttatgc ttatacacga aaaaatgaac ggtaaagagg atacaaattg 1006201 cagacccgcc aattaacgcg gttgcatcat ttccttgtag gttaaacaag agcatgcagg 1006261 cgatatctgc aagaaaggca agcggaatca aaaaagccag tatggaccgc aggcgttttg 1006321 gcaagtacag cgagttgtct tgttcgccgg aaagaacggg ggaaaaagaa gtgggatgct 1006381 cctgtttttt gcgttcgcgc tgaatcatga taaaggcagc agttgttgtt gtcacaccca 1006441 taatcagcac aagcggaata ctggccgaga cgacatcacc gactggaatg cctgctgcat 1006501 ccgcagtcag ctttggcgcc gcctgaatga caaagtctcc tgacagggca aaaccgtgtc 1006561 cgaataagtt catggccatg gccgcggcaa gaggcgtcaa accggcacgt gcggctgcgg 1006621 ggagcaggac ggcgccgatc aaagcgacac ccggagaagg ccagaagaat agagaaatgg 1006681 cgaacatcag gcctccaatc agccaatagg cagtcacagg ccctctcaca aggcttgcaa 1006741 agggagaaat catcgcttca tttatccctg tttttgttaa caaatcactc attgaaacga 1006801 taaagcaaat gatgaaaatc gtgggcagca gttcgccggc cgcatagata aagctgtgga 1006861 ataaactgct gacagaagct gaaagtgaat ggctggccca tagcgatatg ataaaaatgc 1006921 cgaatagaga aataaatgtc gtgtcttttc tcagcagcat aaataggata attgcaccga 1006981 taaaaaacac atacagaaca tggacaggca aaatcccgac ttccatcatc gatcactcct 1007041 tccgcttaca gattattcat aggcgggcgg aaggtgccgg gacagagggg agggttatga 1007101 tggaagatga acattgatct gtttcagctg ctcaatcaga tgatgcctta atcctctatt 1007161 cgctttttgc agatgttttg ggaagcattc aggagaaaaa atgacgcacc cttcagcaag 1007221 ccagtttttt ctataggcga tgatgctttc cgatggctct atatgagtta tcctcgtgct 1007281 gcatctcgta ctcatcaaat ccgaactgaa aaccgcagca cgggcagatt tcatgagaat 1007341 gattgccttc atgatcatat ggcggttcag ccaatcctta aacccgcaga ctgggcaagt 1007401 atgcttcatt ttgctttcct cccaataaaa taagctgccg gacatgccgg cagctattcg 1007461 acagcgaaat atgtggtgac ataggaaggc cgggagaaga tcgacgttgt gtcaattccg 1007521 gcagatgtat cgcgtttttt gtgggcttct ttgtaagaac cggactgctg ccagtcttga 1007581 aaggcgcttt ccgtttccca caaggtcaga atgacatagg tgtcactgtc aagcggacgg 1007641 agcactcgaa ttgcttcaaa gccaggctcg ttttcgactt ttcccgctct gtttttaaat 1007701 ctgttttcaa acagcggacg cccttcctga gtaacggcaa tattgttcaa tactgcaaaa 1007761 ccgggatgtt tgatctctcc gacttggtca atgacttcat aagcgtgtgg tgcctggaaa 1007821 acggtatctc cgtttgtttc atgaattaaa atggcgtttt cctgcccctg catcaaaagg 1007881 atattttctg agggatgctt ctgtacgatc gtttttaaaa aatcggctgt cccatatgta 1007941 atataaacct tcatatcagc cacctcctgc ttgctagtat atcaaaacaa tggtataagt 1008001 ttctattggc gagtgcttcg aacataattc caaacaattt ttcccatact acctttagaa 1008061 aggcgaggtg agttcatgtt taagataaag aaaaagaaac tttttatacc tatcattatt 1008121 ttagtgttaa ctgcttttct cgctttaata ggatatattt caattatttt tctcggccat 1008181 tatgtcatag atgaaaaaaa gcttattctt catgcttctt caaaaattgt tgatcaaaac 1008241 ggagatgagg ttgcaagcct gtatacagaa aatcgcgagc cggtctcgat caatgagatt 1008301 cctaagcagg tcagagaagc gtttatcgct gttgaggata aaaggttcta tgagcatcac 1008361 ggcattgatg caaaatccgt cggaagggca gtgtaccgcg atatattagc aggcggaaag 1008421 gtggaaggcg gaagcacgat cacccagcag cttgccaaaa atatttttct gacacatgac 1008481 aaaacatttc taagaaaaac aaaagaagtg atcattgcga ttaatcttga acgggattac 1008541 agcaaggaca agctgcttga aatgtattta aaccagcttt acttcggaca cggggtttac 1008601 ggcatacaag cggcgtccca ctattatttt aataaagaag taaaagattt gactgtatct 1008661 gaaggcgctg ttttggccgc tattccgaag gcgccttcta cgtactctcc aattttgcac 1008721 cctgataaaa ataaggagcg gcgtgataca attctaggta tgatgaatga ccaaggctat 1008781 atcagtgcga aagaggctgt caccgcacag ggccggacgc ttggactgca tgtgaagaaa 1008841 cagtcggaaa caccttggtt tgacagctac attgaccttg tgatcaaaga ggcggaagac 1008901 aagtattcca tttccggaga gcagcttctt caaggcggat acacgatcaa ggtgccgctc 1008961 gattcgaagc tgcagaagac ggcttaccag gtgatgaaag agggaagcta ttatcccgga 1009021 acagatcaga atgccgaggg aagcgcggtc tttattaata acaagacagg cggtgtagaa 1009081 gcggccatcg gcggaaggga ttacacatcc aaaggatata accgtgtcac agctgtccgc 1009141 cagccgggtt ccacatttaa gccgcttgct gtatacggac cggcgatgca ggaaaagaaa 1009201 tttaagccat attctctatt gaaggatgag ttgcagtcct acggagatta tacgccgaaa 1009261 aactacgaca gccggtatga gggcgaagtc actatgtctg acgccattac gtacagcaaa 1009321 aacgcgccgg ctgtctggac gctgaatgag atcggcgtcg aaacagggaa atcttatttg 1009381 aaagcaaacg gcattgatat ccctgatgaa ggccttgctc ttgctctagg cggcttggaa 1009441 aaaggcgttt caccgctcca gcttgccggc gcgtttcata catttgccgc gaatggaacg 1009501 tatactgaac ccttctttat ctcgagcata atagatgaag acggagaaac aatagccgat 1009561 cataaagaag aaggaaagcg ggtattcagc aagcagacgt cttggaatat gacgagaatg 1009621 ctgcagcagg tagtcaaaaa gggaacggcc acgtccggca cctatcacgg cgacctggcg 1009681 ggaaaaacag gttcaacatc ttatacaggc gtctccggcg cgacaaagga cgcctggttt 1009741 gcaggctata cgccgaaaat aaccggggca gtctggatgg gctatgacaa aacggatcaa 1009801 aaccattatt tgaaagccgg gagctcatac ccgacgcggc tgtttaagga tattttgaca 1009861 caggcaggag aaaccggtca tgtgttcaca aagcctaaaa acgttaaaga actggaaagc 1009921 ccgattgagc tgaagccggt caaaacactc acagccgatt acacatttaa agcagcgggg 1009981 ctctttacta ttgaattaaa gtgggacgct caagaggatg atcgggccgt atacagaatt 1010041 tatgtaaaca aggacggcga ggagacgctt cttgattcgg ttgaagggaa gggaagctat 1010101 gaaattcctt atgccaactt attttcgggc gcgtcttata aaattgtgcc ttataataca 1010161 cagacaaaaa gagaagggga aggaaccgat tacgttcagc caaaattgtt ttcctcttaa 1010221 tggaattcgg cgattttttg aactttgagc tacatttcta taccatttgc ctaaaacaag 1010281 gtatagtgta ataagtcaag aaatacgaac gtatggttgc cgtatgaaag gtggaaatca 1010341 gatgagtaaa cgagaaacgt ttaacgagac gtttttaaaa gctgcgcggg gagaaaaagc 1010401 ggatcacacg cctgtgtggt atatgaggca agcagggcgc tcacagccgg aataccgcaa 1010461 gctgaaggaa aagtacggat tgtttgagat cacacatcag cccgaacttt gtgcgtatgt 1010521 cacaagactg ccggttgagc aatacggagt cgatgctgca atcctttata aagatatcat 1010581 gacgccgctg ccgtcaatcg gtgtggatgt tgaaatcaaa aacgggatcg gtcctgtgat 1010641 tgatcagcca atccggtctc tggcggacat tgaaaaactc ggccagattg atccggaaca 1010701 ggacgtgccg tacgtgcttg agacgattaa actgcttgtc aatgagcagc tgaacgtccc 1010761 gctcatcggt ttctcaggtg cgccttttac gcttgcaagc tatatgatcg aaggcggccc 1010821 gtcgaaaaac tacaataaaa caaaagcctt catgtacagc atgccagatg catggaatct 1010881 gctgatgtcc aagcttgccg acatgatcat cgtgtacgtg aaagcgcaga ttgaggcagg 1010941 cgcaaaagcg attcaaatct ttgattcgtg ggtcggcgca ttgaatcagg cagattacag 1011001 aacatacatc aaacccgtga tgaaccggat cttttcagag ctcgcaaagg agaatgtgcc 1011061 gctgatcatg tttggcgttg gcgcaagcca tcttgcaggt gattggcatg accttcctct 1011121 cgatgttgtc gggcttgact ggagactcgg cattgatgaa gccagatcaa aaggaattac 1011181 taaaacagtg cagggcaacc tggacccgtc cattttgctt gcgccatggg aagtcattga 1011241 gcagaaaacg aaggaaatac ttgatcaggg tatggagtca gacggcttca ttttcaatct 1011301 tggccatggg gtatttcctg atgtcagtcc cgaggttttg aaaaaactga cagcatttgt 1011361 ccatgaatat tcacaaaaca aaaaaatggg tcaatattcc taagcatatc ttttggtatc 1011421 ttaatgatat cctgtcaaaa tgtttgtatc agatcattaa agagggtgta aacagtgagt 1011481 agaaagaaaa tggggcttct cgtgatggcg tacggcacgc cttataagga agaagatatt 1011541 gaacgttatt atacacatat cagaagaggc agaaagcctg aacctgaaat gcttcaagat 1011601 ttgaaagaca gatacgaagc gattggcggc atttcaccgc ttgcccaaat cacagaacag 1011661 caggcgcata atctggaaca gcacttgaat gaaattcagg atgagattac gtttaaagcg 1011721 tatatcggac tgaagcatat cgagccgttt attgaagacg ccgtagcaga gatgcataag 1011781 gatggcatta cagaagcagt cagcatcgtg ctggcgccgc atttctccac gttcagcgtt 1011841 cagtcctaca acaaacgcgc caaagaagag gctgaaaaac tcggcggctt aacgattacg 1011901 tcagttgaaa gctggtacga tgaaccgaag ttcgtgacat attgggttga ccgagtgaag 1011961 gaaacatatg cgtcaatgcc tgaggatgaa agagaaaacg caatgctcat cgtatccgca 1012021 cacagcctgc cggaaaaaat caaagaattt ggagacccgt acccggacca gcttcatgaa 1012081 tcggcgaaat taattgctga aggcgcaggc gtttccgaat atgctgtcgg ctggcaaagt 1012141 gaagggaaca cgcctgatcc ttggctcgga cccgatgttc aggatttaac acgtgattta 1012201 ttcgaacaaa aaggctatca agcatttgta tatgttcctg ttgggtttgt cgcggatcac 1012261 ttagaagtgc tttatgataa tgattatgaa tgcaaagtgg ttactgacga tatcggcgca 1012321 agctattacc ggccggaaat gccaaatgcc aagcctgaat ttattgatgc tttggcaaca 1012381 gtcgtattaa aaaaattagg acgttaaaga aggcgatgaa catgagtgac ggcaaaaaac 1012441 atgtagtcat catcggcggc ggcattaccg gtttagccgc cgccttctat atggaaaaag 1012501 aaatcaaaga aaagaatctg ccgcttgagc tgacacttgt tgaggcaagt ccgagagtcg 1012561 gcgggaaaat ccagactgtc aagaaagacg gctatatcat cgaaagaggg ccagactcat 1012621 ttctggaacg aaagaaaagc gccccgcagc ttgttaaaga cttaggtctt gagcatttgc 1012681 ttgtcaacaa tgcgaccggg caatcctatg tgcttgtaaa ccgcaccctg catccaatgc 1012741 cgaagggcgc tgtaatgggg ataccgacaa aaattgcgcc gtttgtttct acgggtctgt 1012801 tttccttgtc cgggaaggcg agagctgcta tggatttcat cctgcctgca agcaaaacaa 1012861 aggatgatca gtcattggga gaattcttcc gcagacgtgt cggagatgaa gtggtcgaga 1012921 acttaatcga gccgctacta tcagggatct acgcaggcga cattgacaag ctcagcctga 1012981 tgtcgacatt tccgcaattt tatcagacgg aacaaaagca tagaagcctg attctcggca 1013041 tgaaaaaaac aaggcctcaa ggctcaggcc agcagctgac ggcaaaaaaa caagggcagt 1013101 tccaaactct gtcaaccggt ttgcagaccc ttgtagaaga gatcgaaaag cagttaaagc 1013161 tgacgaaggt gtataaaggc acaaaagtga ccaaacttag ccatagcggc tcttgctatt 1013221 cgctcgaact ggataacggc gtcacacttg atgctgattc agtaattgtg actgctccgc 1013281 ataaagcggc tgcgggaatg ctttctgagc ttcctgccat ttctcatttg aaaaatatgc 1013341 actccacatc cgtggcaaac gtcgctttag gtttccctga aggctccgtc caaatggagc 1013401 atgagggcac gggttttgtc atttcaagaa acagtgactt tgcgatcaca gcctgtacgt 1013461 ggacgaataa aaaatggccg cacgcagcgc cggaaggcaa aacgctgctt cgggcatatg 1013521 tcggaaaagc cggagacgaa tccattgtcg atctatcaga taatgacatt atcaacattg 1013581 tgttagaaga cttaaagaaa gtcatgaaca taaacggcga gccggaaatg acatgtgtaa 1013641 cccgatggca tgaaagcatg ccgcagtacc atgtcggcca taagcagcgt atcaaggagc 1013701 tgcgtgaagc acttgcatct gcgtatccgg gtgtttatat gacaggcgct tctttcgaag 1013761 gtgtcggcat tcccgactgc attgatcaag gaaaagctgc cgtgtctgac gcgcttacct 1013821 atttattcag ctaaaacctc cgctttatcg cggaggtttt tttgatgtgc aatggcaata 1013881 ttgtgtaaaa aatgattgaa ttgaacagca ggttatgata catttgcata tgtacttaat 1013941 gactaaaatg ttcaaacggt cagtttcgag gtgaatacaa tgtcaataga tcgaaaaaag 1014001 ctcattttgg aggcggctac aaagtctttc acgcagttcg ggtataaagc gacgacaatg 1014061 gatcttgtcg caaaacttgc gaacgtgggg aagggaacca tttatacttt tttcaaaaac 1014121 aaagaagagc tgtttgacga gattttcact actttattaa aggaaatgaa gcaaaaagcg 1014181 gatgaagcga tggagccgag ccttccgttc catgaaaatg tgcacagagc gctgtttgcc 1014241 attctggagt tcaggaaaac acatcagctg acgattaaaa ttttccaaga gaatgccgag 1014301 attggtacaa tggcagttca ggaagtgatc cagaaaatgg agcgatccat cctgtcttat 1014361 atcaaaagca agattgaaga cgggatcaaa agcggcgcaa tcaagccgtg cgaccctgag 1014421 ctgacagcct ttgtgatgct gaagctttat atcgcgctca tttttgactg ggaaaaacaa 1014481 caccccccgc ttgataaaga gacaattgcg ggactgcttg aattgtatgt tgtcaaagga 1014541 ttgtcagcga actagataat cctttctctt tgcaagaaaa tgaccatttt ttatgatgag 1014601 tcagttttag aatggaggca tcaggatgaa cacaatacga agtcagtgga aagacatcgt 1014661 aacaagtaaa aaattattga ttcccatcat cgccattttg tttgtcccgc ttatttacag 1014721 cggcgtattc ttaaaggctt attgggaccc gtacggcaca gttgaccagc tgcctgtcgt 1014781 tgtcgtcaac caagacaagg gagcaacgta tgaaggagaa aaacttcaaa tcggtgatga 1014841 tctggtcaaa gaattaaagg ataataacaa ctttgattgg catttttcca atgatctcga 1014901 ccaatcgtta aaggacttat tgaatcaaaa atattattta gttgtcgaga ttcctgagga 1014961 tttttctaag aatgccagca ctgtattaga caaaaatccg aaaaaattgg atctgaaata 1015021 ccatacaaat gcaggttcta actatgtagg ggcaacgatc ggcgaaaaag cgattgataa 1015081 actgaaagcc tctgtttcaa aagaagtgac cgagcaatat acgaaagtta tttttgataa 1015141 ctttaaagat atcgcaaaag gtttgagcga cgcgagcagc ggcgcgaaaa aaattgatga 1015201 cggcacaaag gatgcgaaaa acggaagcgc ccagctgaaa gaaaatctgg cgaagctgaa 1015261 ggaaagcacc gctaccatca gtgacaaaac agcgcagctt gcagatggag cggctcaggt 1015321 gacgagcggc atccaatcac ttgacagctc gctcggtaaa ttccaggaca gcagcaacca 1015381 gatttatgat aaatctagtc agcttgcagc aggatcaggc gagctgacaa gcaagatgaa 1015441 tgaacttctt gccggacttc aaaatgtgca gaagggtacg cctaatctta ctaacgggtt 1015501 ggatcagctc aacagtaaag tccaagaagg ttctgagaaa gcggcaaaag cggaaaagat 1015561 cattaatgcg ctcgatttaa cgaagcttga aactgctgta aacaatctgg aaaagtcaga 1015621 aactgcgatg aaggaattca aaaaacagct gactgacttt gaaaacagtt tgaaaaaccg 1015681 tgatcaggca tttaaaaatg tcatcaattc gagtgacttc ttaacagcgg agcaaaaaag 1015741 ccagctgatt aattctgttg agaaaaagct tccgcaagtt gatgcgcctg attttgatca 1015801 aatattaagc cagctaccta cagctgatca gctgcctgac atcgcaacga taaaaagctc 1015861 tcttgaagac gtgaaagcgc aggtggcgca ggtgaaagcc atgccggaag ctacatctaa 1015921 gctttataac ggcgcaaaaa caatccaaga tgcgattgac agattaactg agggagctga 1015981 taagatatac aacggttctc agaagctgac agatggccaa actaaactga cagcgggcat 1016041 cggtgaatat aataagcagt tcgcaaaagc aaaagcgggc tcagagcaat tggtgacagg 1016101 aagcagccaa gtatccggcg gattgtttaa gctgttagac gggtctaaac aggtccaaag 1016161 cggatcatca aaacttgcag acggatctgc atcacttgat acaggtttag gcaagctatt 1016221 ggacggcaca ggagagctgt ctagtaagct gaaggatgcg gctgaccaaa caggagatat 1016281 cgatgctgat gatcaaacat acggcatgtt tgcggatccg gttaaaacca aagatgatgc 1016341 cattcattcc gttcctaact atggaacagg gctgacacct tatatcctgt caatgggctt 1016401 gtatgtcggc ggcatcatgc tgacggttgt cttcccgctg aaggaagcgt caggacgtcc 1016461 gagaaacggt tttgagtggt tcttcagcaa attcaatgtc atgatgcttg taggaatcat 1016521 tcaatcattg attgtggcga cggttcttct attgggaatt ggtcttgagg tagagagcac 1016581 gtggagattt tacgtgttta cgatcattac gagtctcgct ttcctggcga taattcaatt 1016641 tttggctaca acgatgggca acccggggcg atttatcgca gtcattattt tagtgctgca 1016701 gctgggagcg agcggaggaa ccttcccgct ggaattgctt ccgaatttct atcaggtcat 1016761 ccacggcgca ttgccgatga cctacagcat taacggattc agagcagtca tttcaaacgg 1016821 tgactttggc tacatgtggc agatggccgg cgtcttaatc ggcattgccc tcgtcatgat 1016881 tgcactaagc attacttact ttacaatgtt aagccggaag gaagaaacat cagaagaaca 1016941 gccggcttca taaagaaaaa gaacttgttt ccttggaaac aagttctttt tttgttacat 1017001 cccccattta ataagcaatc ctgtataggt taatccgccg ccaaacccga aaagcaaaac 1017061 gatttgatct tttttcagct tcccggcttt cactgcgaga tcgagcgcca aaacaattga 1017121 aaccgaagac gtgtttccgt agtgctcaac actagtgagc gttttttcaa tcgggaacgg 1017181 tgttttttca caaattgact cgatcatgcg caagttggcg ctgtgaggaa caaaccaatc 1017241 gagatcatcg gagctgagtc ctgctttatg taaaagccgt tcaaattcgc cagggacggt 1017301 tcttgcggcc catttatata cctcgcgtcc gttttgcacc atttttccgg aaccgacaag 1017361 ctgcacaccg tttatttcat ttcgcagtcc ggcacgatac aaaatatcgc cgccgttccc 1017421 gcttgttcct tgtacagacg caagaaatcc cggcgtctct tcatctcgtt ctactaacag 1017481 cgcacccgcg gcatcgccga acagtacgca tgtcgttcga tcggtataat cggttacctt 1017541 tgataacgtc tctccggcga tgacgagaat tttttgatga aggccagatg tgatcaatcc 1017601 atttgccaaa tggaggccgt atgtcagccc ggcgcatgtc gcattaatat ccagcgcgcc 1017661 ggtgctttcc cagccgaaat attcctgtac gcggcatgcc gtactcggaa aggcgtaatc 1017721 ggatgtggtt gtggcaacga ggatcatatc gacatcatca agcgttcctt tataacggct 1017781 cttgagattc ttcaccgctt ctatgcataa atcagaggta aattgatgtt catccgcaat 1017841 ccggcgttct ctcattcctg tgcgctgaac gatccattca tcagaggtat caacgatctt 1017901 ttctaaatct gcattggtta aacgtctgct cggcgcatag gtgccgatag ctgtaatttt 1017961 tgcttttgac atatgaatca ctccttatgg tcagattata acactagata ttagtatctg 1018021 gtactaaaaa gaaggttttt ttacaaaaaa agagaagtgt agataggaat ctatgaaaaa 1018081 gaaaaaggag gctgaaaaat ggtcagtcaa gaagcagtag tctttttggc attatccggg 1018141 gctattgcgt ttctgttgcc aatcgggctg attgtatggt ttaagcgaaa gtatggtgcc 1018201 tcgcttaaag tgttttttat tggcgctctc acgttttttg tcttcgctca gctgctggaa 1018261 ggcggcgttc atgtttatgt actgcaagtg aatgaaatga cgaaagaagc gatgcagcat 1018321 ccattatggt atggcattta cggctgcttg atggccggca tttttgagga gtgcggaagg 1018381 tatttgatga tgcgattttt tatgaagcgc catcatactt gggcagatgg tctggctttc 1018441 ggggcaggcc atggcgggct tgaagccatc ctgattacag gcttgtcctc tatctcactt 1018501 attgtatacg catttgcaat caatagcggg acgtttgaac agcttttggt caatggcgac 1018561 gtcaaacagg cgcttttgcc gatacaggag cagctgctgc atactccttc gtatgaatgg 1018621 atgctgggcg gaatagaaag aatcagtgcc attgccgtcc agattggtct gtctctgctt 1018681 gttttgtacg cggttaaaaa ccgccggccg ctgtttttgc tgtattctat tcttttacat 1018741 gcactgttta atgtcccggc ggttttatat caaagaggaa tcatagagca tgctgcagct 1018801 gttgaaatca ttgttgctct tatagcggct ttatcagttt attggattgt aaaagcaaaa 1018861 agggtgtttc aataaaaggt ccaagcagca gcaatgcccg cttggaaaaa tgtgaatgga 1018921 aatattcatt aagcatgggt catcagaata tttctgattc agtctttagc aatgacagca 1018981 agaatgtctg tgttttttac aagagaaaca atggtgtttc tttttcttct tctcgcaagg 1019041 gtcatggcat tctttctttt tcttgcaatg gtcgtggaaa tctttatcga accactcgtc 1019101 aaagaaccaa aaatcatcga accaatcgtg acaacgacat ttctgttcat gtgaatgacg 1019161 acagcacata gaaatccctc ctcttcccat gctctctaca gcatatgaga gattgatagg 1019221 aaaagattgg acgggtccct cgggaaaaga gtatatttta agtagaaaat aaaaggagga 1019281 atgccctatg acgtccgtac gtaaaacgat ggagctcatt aaagaacttg tatcgatccc 1019341 aagcccgaca ggaaatacat atgaggtgat caattatatt gaaagccttt taaaagaatg 1019401 gaaggtagaa acggttcgga accacaaggg cggcttaatt gcaacgcttc caggacgcga 1019461 cacatcccgg catcgcatgc tgacagcgca cgttgacacc ctcggcgcta tggtgaagga 1019521 aattaaagcg gacggccggc tgaaaatcga cttaatcggc gggttccgct acaactcgat 1019581 tgagggggag tattgccaaa ttgaaaccgc ctcgggaaaa atgtacacag gcacaatctt 1019641 aatgcatcaa acgtctgtgc acgtatacaa agacgcggga aaggctgagc ggaatcaaga 1019701 gaatatggag atccgcctag atgaacctgt tcactgccgg aaagatacgg aggagcttgg 1019761 cattggcgtc ggagactttg tgtcgtttga tccacgtgtc gagatcacat caagcggatt 1019821 tattaaatcg cgccatttgg atgacaaagc aagcgtcgcc ttattgctcc gcttaattca 1019881 tgaaattcaa acagaagaca ttgagctgcc gtatacaacc cattttctta tttccaataa 1019941 tgaagaaatc ggttacggcg ggaattcgaa tattcctcct gaaacagttg aatatttggc 1020001 ggttgatatg ggcgctatcg gtgacgggca ggcgacggat gaatattcag tatcaatctg 1020061 tgtgaaggat gcgagcgggc cgtatcatta tcagctcaga aagcatttag ttcaattagc 1020121 cgagaagcat catattgact ataagcttga tatatatccg tactacgggt ctgatgcgtc 1020181 agcagcgatc aaatccgggc atgatattgt gcatggcctc atagggccgg gaattgacgc 1020241 ttcccatgca tttgaacgca cccataaatc atctcttcgc cataccgcta agcttctgta 1020301 ttactatgta cagtcaccaa tggtataagg gggaggacca atgaagattt ataagctgaa 1020361 aagcacattc ggttgggaag gtgatgacgg gttgggagaa cagctgattc agcagatcct 1020421 tgccggagaa aaaagcgcca cgtgcgcgcc gaaatcattg tattcaaaag atgaattgag 1020481 ggacgtttat caaacagcgg gtcagcttgt taccgtttat gataaacatg acaatccaag 1020541 atgcaatata aaagtaacag atgtctttga aaccaccttt ggtgcgcctg atatgaggtt 1020601 agtcaaagga gagggcaatg gagaccgaat tgaggagttt caagaggatc atcggatggc 1020661 atgggcggaa ctgatcaaaa gcggtgaact ggagctgaat gaggatactg ttttgattac 1020721 agagttgttt gtgcttgtta aagattaaaa aagcctgcgg ggcaagaacc ccgcaggctt 1020781 ttcattaacc agaaatggtt gcgttttgtt ctgttttcga ttgggacata acagtttctg 1020841 ctttcgcagg attaaacatg ccttcccatt tagacatcac aacggcagca agcgcgttac 1020901 cagtcaggtt gacaactgta cgtgccatat ccatgatgcg gtctacgccg gcaataaagg 1020961 caagtccttc agccggaacg ccgatggtgc caagcgttgc aagcaagaca acaaaagaag 1021021 taccaggtac ggcagccatc cctttggatg tcaccattaa gacgagcaca agcgtaattt 1021081 ggtgccaaat cgtcaaatca atgccatata cctgtgctaa aaagagtgcg gcaatagatt 1021141 gatagagaac ggaaccgtct aagttaaacg tgtaaccgat cggaatgaca aatgaaacaa 1021201 tgccttttgg acatccgatt ttctccattt tttccatgat acgcggaaga accgtttcag 1021261 agctggacgt actgaacgcc agtaagattt cgtccttcat gtaagcaagg aacttgaaga 1021321 tgctgatgcc ggcaattttt gcgacaatcc cgaaaataac aattaagaag aaagcaagcg 1021381 cgacataaac caatccgacg agctttccga gagagataag agaaccgagt ccgaatttag 1021441 acacagtcac tccgataaga gcgaaaacgc cgaatggcgc cactttcatc acaaggttta 1021501 caacgtggaa catggcatgg gatacacctt caaaaaaggc taatacaggc ttgcctcttt 1021561 caccgatcgc ggaaataccc aatgcaaata gtactgtaaa gcagatgatg gctagaagat 1021621 ccccttcgac caatgactgg aagaagtttg tcggcacaat atggaggaac gtttccgcca 1021681 ctgatttatt actttgttct ttttcagttt caacatattg actgatgtcc gatttttgag 1021741 cttcgtgtat attaactcct gtacccggat ggaagatgtt tgcaagggct agtccgagaa 1021801 taatggcaaa agtcgtgatg atctcgaagt acagaatcgt tctgaagcct aatttaccga 1021861 cttgctttcc atttcctgca ccggctacac cgatgattaa gctggagaca acaataggaa 1021921 tcactatcat tttgattaag cgtaaaaaga gatccccgat tggctgcagg taagtaggca 1021981 atgctgggtt gccataccaa atgacgccaa caatgacacc tagaataagt ccaacgaata 1022041 tttgtgtggc taatccaaac ttaattcttt tcatagatta cctcccaaaa aacaaagtat 1022101 caacatatat catgaataga catatattta atctcactat tagatcaaat tataatagat 1022161 aagaaatcaa ttcgtctata gtaaattata tttcgaaaat aaagaatatt caatgacatt 1022221 atgataatca ccagaattat ctaaaaacag gtgagctttg acctaacctg actattattt 1022281 caaaattaag agatatgtga aaaaataaga aaatcccacg cgtaaggcgc gggattttcg 1022341 ctcattacaa atcgtttact tttatacagt cattgcagat attaccataa cactcatgct 1022401 gctcttctat cttttttccg cattccgcac actttttcga aggcaggttt ctaaaaaatt 1022461 ctgtgatttt ccccagcata accaatccct ctttcccctt tgtagtgatt tcattgtaat 1022521 ataacagatt acaaaaatca ataactgttt tgatacaatg tttaaaacat gcttttttca 1022581 agaaaaatgg gtatattgaa ggaggaccaa tttttttgaa aagataggag gacattatga 1022641 aagttacagt tatcggatgc tatggcggtt ttccggccgc aaatgaagcg acgtcaggct 1022701 atttgtttca gtcaggtgat tactctctgc ttgttgattg cggcagtgcc gtattgtcta 1022761 agctgttcgg atatgtgccg gcggaaaagc tggatgcggt cgttctgtct cattatcacc 1022821 atgaccatat cgctgatatc ggaccgctgc aatttgccaa gcaagtcggt tcgtttctcg 1022881 gcaaaggaga gcatacgctt ccgatttacg gacatgatgc tgatatagaa cagtttcaaa 1022941 agcttacata taaaacacat acaaaaggga tcgcctatca gccggatcag ccgctgactg 1023001 ccggtccgtt tacgatcacc tttttaaaaa cgattcaccc ggtgacgtgc tatgccatgc 1023061 ggattactga cggcagccac actgtcgttt atactgctga ttccagctat caggattcat 1023121 ttataccgtt ttcgaaagat gctgatttat tgatctcaga atgcaatttt tatgccgatc 1023181 aagacggaac aagtgcaggc catatgaaca gcctggaagc tgggcgcatt gcaaaagaag 1023241 ccggagcggg agaactgctg ctgacacatt tgccgcattt tggcgtgcat gacaaccttc 1023301 gcaaagaagc gaaaaccgtt tttaacggag aagtgaatat tgcgaaatca ggttttgtgt 1023361 gggaaggata aaggaggagc accatgttat ttatagacaa tcaaaatatc aatgatccgc 1023421 ggatcaatct tgctatcgag gagtactgtg taaagcattt agaccctgaa cagcaatatt 1023481 tgctctttta tgtgaatcaa ccgtctatta tcattgggaa aaaccaaaat acaatagaag 1023541 aaatcaatac aaaatatgtt gaggaaaacg ggattatcgt cgtccgccgt ttatcaggcg 1023601 ggggcgctgt gtaccatgat ctggggaact tgaacttcag ctttattacc aaggatgacg 1023661 gggacagctt tcataacttt aaaaaattca ctgagccagt gattcaggcg ttacatcagc 1023721 ttggggttga agccgaatta agcggccgga acgacattgt agtagatggc cggaaaatat 1023781 ccggaaacgc tcagtttgca acgaaaggcc gtattttcag ccacggcacc ctcatgtttg 1023841 attcagccat tgatcatgtt gtatcagcat taaaggtgaa aaaggataaa attgaatcaa 1023901 aaggcatcaa atcgatcaga agccgagtgg caaacatcag tgagtttctc gatgataaaa 1023961 tgaccaccga agaattccgc agccatttgc ttcgccatat ttttaacaca aacgacgttg 1024021 gaaacgtgcc ggagtataag ctgacggaaa aagattggga gaccattcat caaatttcga 1024081 aagagcgcta tcagaattgg gattggaact acggccgctc accaaaattt aaccttaatc 1024141 attcgaagcg ttatccggtt ggatcgatcg atttgcacct ggaagtcaag aaaggcaaaa 1024201 tcgaggactg caaaatcttc ggagatttct tcggtgtcgg tgatgtatct gaaattgaaa 1024261 acctgctggt cggaaaacaa tacgaacgca gcgtcatcgc tgatgtgctc gaaggtgtga 1024321 atctcaagca ttactttggg aacattacga aagaggattt ccttgatctg atttactaag 1024381 gcaaaacaca tcgtttgaaa gagcggttgt gtttttgaaa taatggaggc aggagggatt 1024441 cacatgaaag tgtttttaat cggagcgaac ggacaaatcg ggcaaagact cgtctcttta 1024501 ttccaagata atcctgatca ttccatcaga gcgatggtca gaaaagaaga acagaaagcg 1024561 tctcttgaag ctgccggtgc agaagctgtg cttgcgaatc tggagggcag cccggaagaa 1024621 atcgccgctg cggcaaaagg ttgtgacgcg atcattttca cagccggttc cggcggcagc 1024681 acaggctatg ataaaacgct gctggtggat cttgatggag cggcaaaagc cattgaagct 1024741 gcggccattg ccggaatcaa acggtttatt atggtcagcg ccctgcaagc ccataaccgt 1024801 gaaaattgga atgaggcact caagccttat tatgtggcca agcattatgc tgataaaatt 1024861 ctggaagcga gcggtttaac ctatacgatt atccgtccgg gaggccttcg caatgagcct 1024921 ggaacgggaa ctgtttcagc agcgaaggat ctggagcggg gatttatttc ccgtgatgac 1024981 gttgcaaaaa cggtcattgc ctctttagat gagaagaata cggaaaatcg ggcctttgat 1025041 ctgacagaag gagatacgcc gattgccgaa gcattgaaga aactatgaca gtactgacac 1025101 tcagggcttt ttgctcttga gtgttttttt ctgtttctct ataatggaga agaaagcttg 1025161 gcttcaataa tgaatgacta ttcattcact taaggggtgg gagaatgaat cttgtttcaa 1025221 aattggaaga aacagcatct gagaagcccg acagcatcgc atgcaggttt aaagatcaca 1025281 tgatgacgta tcaagagctg aatgaatata ttcagcgatt tgcggacggc cttcaggaag 1025341 ccggtatgga gaaaggggac catttagctt tgctgcttgg caattcgcct gattttatca 1025401 tcgcgttttt tggcgcttta aaagctggga tcgtagttgt tcccatcaat ccgttgtaca 1025461 cgccgacaga aattggttat atgctgacaa atggcgatgt aaaggcaatc gtgggcgtta 1025521 gccagctttt gccgctttat gagagcatgc atgaatcgct gccaaaggtt gagctcgtca 1025581 ttttatgcca gacgggggag gccgagccgg aagctgcgga cccagaggtc aggatgaaaa 1025641 tgacaacgtt tgcaaaaata ttgcggccga catctgccgc taaacaaaac caagaacctg 1025701 tacctgatga taccgcggtt attttatata cgtcaggaac gactggaaaa ccgaaaggcg 1025761 cgatgctgac acatcagaat ttgtacagca atgccaacga tgtcgcaggc tatttgggaa 1025821 tggatgagag ggacaatgtg gtctgcgctc ttcccatgtt tcacgtgttt tgtttaaccg 1025881 tctgtatgaa tgcaccgctg atgagcggcg caactgtatt gattgagcct caattcagtc 1025941 cggcatctgt ttttaagctt gttaagcagc agcaggcgac catttttgcc ggtgtgccta 1026001 caatgtataa ctacttgttt cagcatgaaa acggaaagaa agatgatttt tcttcgatcc 1026061 ggctgtgcat ttcgggaggc gcgtccatgc cagtcgcgtt gctgacggcg tttgaagaaa 1026121 aattcggtgt taccattttg gaaggctacg ggctctcgga agcatcaccc gtcacgtgct 1026181 ttaacccgtt tgacaggggc agaaagccgg gctccatcgg gacaagtatc ttacatgtcg 1026241 aaaacaaggt cgtagatccg ctcggacgcg agctgcccgc tcaccaggtc ggcgaattga 1026301 tcgtgaaagg ccccaatgtg atgaagggct attataaaat gccgatggaa acagagcatg 1026361 cattaaaaga cgggtggctt tatacggggg acttggcaag acgggatgag gacggctatt 1026421 tttacattgt tgaccggaaa aaagacatga tcattgtagg aggatacaat gtgtatccgc 1026481 gggaggtgga ggaggtgctg tacagccatc cggacgtcaa ggaggcggtt gtcatcggcg 1026541 tgccggaccc ccaaagcggg gaagcggtaa agggatatgt ggtgccgaaa cgctctgggg 1026601 taacagagga ggacatcatg cagcactgcg aaaagcatct ggcaaaatac aagcggcctg 1026661 ccgccattac gtttcttgac gatattccga aaaatgcgac ggggaaaatg ctcagacggg 1026721 cactgagaga tattttgccc caataaaatg aaaaagcgaa gcggttagct tcgctttttc 1026781 attttcaatc ctttgcttct tttttaataa tatttagcag cgcctttgta tcatttttgc 1026841 ttaatttgta gtatgtgcca tccttcaaaa aaacggcttg ctggctgccg tcaatccata 1026901 gtctgaatga gtcataccgg tctttatgaa acttgattgt cccttcgtaa tcaggggctg 1026961 atgttttttc tgtcttcacc tgttttccct gattcataat atccagcata tctttgacgt 1027021 gctgtctttt ttcaatctcg atatcttcct ggccgcttga agacagtgtg atcaaatccg 1027081 cgtctaccga ttgatacaca tcgcctgatc ggctgtaaag ataaaaaaat gcgataaaca 1027141 caagaccgat taccacgatg gctgccacta tttttttcat ttgcatcact ccaaacattg 1027201 ttagttttcc cagcgatcgg ggtttccatg cttaaaaggg tggaaaagtg cggaacacag 1027261 cttggttcta agaatttgaa tttatgatta caatagaagt aacgggttga tgtgaggagt 1027321 gaggcgttat gcgcaagtgg attgcggcag caggacttgc ttacgtgctg tacgggctgt 1027381 ttttttattg gtattttttc ctgtcgggtg attccgcaat accggaagcc gtgaaaggga 1027441 cgcaggctga tccggcttct ttcatgaagc cgtctgagtt ggcagtggcc gagcagtatt 1027501 cgaatgtcaa gaatttttta ttttttatcg gggtaccact tgattggttt ctgttttttg 1027561 ttctgcttgt cagcggtgtt tcaaagaaaa tcaagaaatg gatcgaagcg gccgtgcctt 1027621 ttcggttttt gcagaccgtt ggttttgtgt ttgtgctttc gctgattaca acattggtga 1027681 cgctgccttt agattggata ggctatcaag tatcgcttga ctataacatt tccacacaga 1027741 caacggccag ctgggctaag gatcaggtta tcagcttttg gatcagcttt ccaatcttta 1027801 cgctttgcgt tctcgttttt tattggctga tcaaaaggca tgaaaaaaaa tggtggttat 1027861 acgcctggct gttaacagtg ccgttttcgc tgtttctgtt ttttattcag ccggtcatta 1027921 tcgatccttt atacaatgat ttttatccgc tgaaaaacaa agagcttgaa agcaaaattt 1027981 tagagctggc agatgaagcc aatattccgg ctgaccatgt atatgaagtg aacatgtcag 1028041 aaaaaacaaa tgcgctgaat gcctatgtta caggaattgg ggccaataaa cggattgtat 1028101 tgtgggatac gacgctgaac aaacttgacg attcagaaat tctgtttatt atgggccacg 1028161 aaatgggcca ttatgtcatg aagcacgttt acatcggtct ggctggctat ttgctcgtgt 1028221 cgctcgccgg attttatgtc attgataagc tttacaagcg gacggttcgc ctaacccgca 1028281 gcatgtttca tttagaaggg cggcatgatc ttgcggcact tccgctgtta ttgcttttgt 1028341 tttctgtttt gagctttgcg gttacgcctt tttctaatgc tgtctcgcgt tatcaggaga 1028401 ataaggctga ccagtatggg atcgagttga cagagaacag agaagccgct gttaaaacgt 1028461 ttcaggattt ggccgtgacg gggctgagcc aggttgatcc tccggtgctt gtgaagattt 1028521 tcagaggcag ccatccgtcg atcatggaac ggattcaaca tgcggagaaa gaagagaatg 1028581 cgccggaaca tcaggatgct gacaaataaa aagaagcagg tatggaggaa cctgcttctt 1028641 tttactatta ttgtgcagct gcttgtacgt tgattaaccc ttttccatag tagaaagagt 1028701 ttccaagata tgttgcagtg ctttctaaac gatcacggac ttgcgcgttt gtccaagtcg 1028761 ggtgcttaga aagaattaac gctgctgctc cggcaacgtg aggagtcgcc atggacgttc 1028821 cgttataagc gccgtaagtg cctccaggaa gtgtgctttg gatggacacg ccaggagcca 1028881 tcacatcaag ctcagaacct gcgctggaga atgaagctct ttggttgctg ctgtttaccg 1028941 cacctactgc aatagtagaa ggatattttg cagggtagcc gactgtgctt gtgcttccgg 1029001 atgaaccttc gtttccggct gcggcagcaa cgacgatacc gctggaaacg gctttgtcaa 1029061 cgactgtttt cagcgctgta gaaccagtag gtccgccaag gctcatgttg ataacatcca 1029121 tattgttgga aatggcccac tcaatgccgt taataatcca gctatattgg ccgcttcctg 1029181 ttgaatcaag cacttttact gcatataatg atgcgcttgg cgctacgccc agaacaccga 1029241 ttgagttatt aagagcggca atcgtaccgg ctacatgcgt accgtgagaa ctgccgtcct 1029301 ggtatgggtt tgtttcagaa ggtacgaagc ttgctccgcc tctgacgttt aagtcaggat 1029361 gagaagagtc aattccgctg tcgataacag ctacttttac gttagagcct gtgtagcctt 1029421 gagagtgaag agccggcgct ttaatttgag aaatgccata aggaacagat tgcgcatatt 1029481 catgtgcaat atgatcttct tccacatatg caacgctcgg atcttttttc aattctttta 1029541 cagctttttc atccaatgtt gctgcggccg cgttaacata cttaaattgc ttttgaacct 1029601 ttccgccttt ttcagaaata acatcctttt tcttggcgga actcatggca ctcattgtct 1029661 gtttaaatcc gacaatgtat ttcttttctg tactgctttt tccggcagcc tgcgcagaca 1029721 tgttgctgaa cgccatcgta aagattaacg ttaacgcaaa caacaagctg atccacaatt 1029781 ttttgcttct cactctttac cctctccttt taaaaaaatt cagagtagac ttacttaaaa 1029841 gactattctg tgaatttatt gtaatagatg gaataatatt ttagtagacc catttttttg 1029901 agatgatttt atctctattt aggtatatca tctctcgcta tttccgtaga gactcgaaat 1029961 aactattttc atacagaaaa gaacgaaaat agacatgagt aaatgttcat tatgctgaaa 1030021 tgtcatgctt ttttaggtta aatgctcctg agtcccggca aattcctgtc gaaaaaattc 1030081 gttcaaatga cctgcgtgtg cttccgtgag aacaatggat attatcgtga tattttttca 1030141 aagcatgatg ataaaagtat tctgaaaaat aaactttaca gaaaagggat agaatgaaaa 1030201 aattattgag agggaggaag aaataagatg aacattcgcc aagcaaagac atcagatgcg 1030261 gccgccattg cgccgctgtt taaccaatat cgggaatttt atagacaggc atccgatttg 1030321 caaggggcag aggctttttt gaaagctcgt ttggaaaatc acgagtctgt tattttgata 1030381 gcagaagaaa atggagaatt cataggcttt acccagctct atccaacgtt ttcttctgtg 1030441 tcaatgaaaa ggatatacat attaaatgac ttatttgtcg ttcctcatgc gcgtacaaag 1030501 ggagccggcg gccggctgct ttctgccgca aaggattatg cagggcaaaa cggggcaaaa 1030561 tgtttaacac ttcagactga gcaccacaac cggaaggcaa gaagcttgta tgagcaaaac 1030621 ggctatgaag aggataccgg atttgtccat tattgtctca atgtgccggc gaagtgaaaa 1030681 tggcggcttg atgatttggt tttttgaacg ttcttcggtt acgatataaa tgaaaaggag 1030741 tgtgccgaat gtcaacgtta tttcaagcct tgcaggcaga aaaaaatgcc gatgatgttt 1030801 cagtccatgt gaaaaccata tcaacagagg atttgccgaa ggatggtgtc ctgattaaag 1030861 ttgcttattc cggcattaat tacaaagatg gtctggccgg aaaagcagga ggcaatatcg 1030921 tcagagagta tccgcttatt ttaggcattg atgctgcggg tacggtcgtc tcttccaatg 1030981 atccgcgttt tgcggagggg gatgaggtga tcgcgacaag ctatgagctc ggtgtctcac 1031041 gtgatggcgg attaagtgaa tacgcttcgg tgcctggtga ctggctggtg cctttgccac 1031101 agaatctttc gttaaaagaa gcgatggtgt acggaacggc gggatttact gcggcgttat 1031161 cagtgcatcg gcttgaacag aacggtctgt ctccggaaaa aggcagcgtg ctagtcacag 1031221 gagcaaccgg cggtgtcggc ggaattgcgg tatcgatgct gaacaagcgg ggttatgatg 1031281 tggtggcaag taccggaaac cgggaggcgg ctgattattt gaaacagctt ggtgcaagcg 1031341 aagtaatcag cagggaagat gtctatgacg gaacgcttaa ggcgctgtcc aagcagcaat 1031401 ggcagggagc ggttgatcca gtcggcggaa aacagcttgc ctcgctttta agcaaaattc 1031461 aatacggcgg atctgtcgca gtgagcggct taaccggcgg aggagaagtt ccggcaaccg 1031521 tgtatccttt tattcttcgc ggagtaagcc tgctcggaat cgattcagta tattgtccga 1031581 tggacgtcag agccgctgtt tgggagcgca tgtcttctga tctcaagcct gatcagctgc 1031641 tgaccatcgt ggacagggaa gtatcattgg aagaaacgcc gggtgcgtta aaagatattt 1031701 tgcaaaatcg cattcaagga agagtgattg tgaagcttta acaggatcag cttgcagaga 1031761 atgttatttt tctgcaagct tttttgtgga caggatgatc agctgctgaa ctgctgtgtc 1031821 gcgaaacaag attttcctgt aagccgaact ttctcttctc attttaaaaa taattggtga 1031881 taatgattct cattccgtgt tatactactc ttggacatct taaccataga aactaccaac 1031941 aggagagact ggaacatatg aaaaaaacac tgattattct tacagtttta cttctttctg 1032001 tcttaacggc tgcttgctcg tcttcaagcg gcaatcaaaa cagtaaagaa cataaagtgg 1032061 cggtaacaca tgatttaggg aagacaaatg tgcctgagca tccgaagcgg gttgttgttc 1032121 ttgagctagg ttttattgat acactgcttg atctcggcat tacgcctgtc ggggttgccg 1032181 atgacaacaa agcgaagcag ctgatcaaca aggatgtgct gaagaaaatt gacggctaca 1032241 catctgtcgg cactcgctca cagccaagca tggaaaaaat cgcttcatta aaacccgatt 1032301 taattattgc tgacacgacc cggcataaga aggtgtacga tcagctgaaa aaaatagcgc 1032361 cgacgattgc acttaataat ttaaatgctg attatcagga tacaattgac gcttcgctta 1032421 cgattgcaaa agcagtcggc aaggagaagg aaatggagaa aaagctgacg gcgcatgaag 1032481 aaaagcttag cgagacaaag cagaaaatca gcgcgaacag ccagtccgtg cttttgatcg 1032541 gaaatacaaa tgataccatt atggccaggg atgaaaactt ctttacatcg agacttttaa 1032601 cacaggtcgg ctaccgatat gcaatcagta cgtcaggcaa tagcgattca agcaatggcg 1032661 gcgactctgt gaatatgaaa atgacactgg agcagctgct gaaaacagat ccggatgtga 1032721 tcatcctgat gacaggaaaa acagatgacc tcgacgccga cggtaaacgc ccgatcgaaa 1032781 agaatgtcct ttggaaaaaa ctgaaggcag tgaaaaacgg gcatgtatac cacgtggatc 1032841 gtgcggtgtg gtctctgcgc cgcagtgtag acggggcgaa tgccattttg gacgagcttc 1032901 aaaaagagat gccggctgct aagaaataaa agaaaagaca ggcaaacgcc tgtctttttc 1032961 ttatttgata aagccggata agtggctgtt gatattatag tcttttatcc gccatttttc 1033021 ttctgcaaat tcaatgttgc tgaggcaggc gttgacgaga cgggtgcttt gaagctccgg 1033081 gtcaccgccg gatatttctg tcagcagggc gtgaattgcc gcaccgtgcg ccacgatcag 1033141 caccttcttg tttggatacg cctgattcac ttttgccaaa ccgcccatca gcctgtcagt 1033201 gagttcttct aaggtttcca tattcggata gatgttatct ggatagcgct ttgtccgttc 1033261 ctccagcggc atgccctccg cgtcgccgta atcgcgttcc ttaaaatcat ccatctcgac 1033321 tatcggaaga tgcagatatt cattaataat ttccgcggtt cttttcgctc ttttcagcgg 1033381 gctcgtcaca ataatatccc aagaaaagtc ctttacatat tctccggttt ctcttgcttg 1033441 gcgttcacct gttgcgttta gcgggatatc ggttttgcct tggcattttt gctgcaggtt 1033501 ccaatcggtt tctccatgtc ttactaaaca aacggctgtc ataaaatccc cttcctgact 1033561 ttattcatat cgctattata ctaaatcgaa agcgtgtgtc ctatgaaaaa gcctatgcaa 1033621 gaacttcaaa taataaagcc agtccgattc cgccgccgct tccgatggct gcaacagcat 1033681 attgacagtc tggccgtctt ttcgcttcat aaaacaatct ggttaccaga gctgcacctg 1033741 atgcaccgta cggatggcca agagctaagg cgccgccgcg cacattgatt tttgaaaagg 1033801 gaatgccgag ttcttgcgag cagacacaaa ttttgacggc aaaggcttca ttgatttcaa 1033861 ataaatcgat atcatcaggt gttacatcgt gtgtatgtaa gagctgacga atcgcgacaa 1033921 ccggtgccgc gggcggaaag ttggggtgaa tgccgctgac agcgctgccg ataaaccgaa 1033981 gcacaggctt aagtcccagg gctgctgctt tttcttcttc cattaccaaa agagcggctg 1034041 ctccgtctgc tatgccactg ctgttggctg ctgtgactgt tccggagctg gtgtcgaaaa 1034101 ccggctttgc acggggaata atcgcttcta ttggccgcgt tttcaaaaat gcttcgtccg 1034161 tctccaattc cccgagagca acaacttctt cacggtaaaa tccttcatca tgcgcgttcc 1034221 tgctgcgttg atggctgaga agcgcgtact catcctgcat gcttctgctg atggaatagc 1034281 gtgcagccgt atattctgcc gcaatgccca tgtctggatc gccgatcgca tctggagaaa 1034341 agcgagcccg ttctgaaaaa ggggattggc tgctgctttc tgagccgccc gcgatataca 1034401 tcgtgccggc tcccgcttga ataaggctgc aggcatagcg cacagcttca aggccggagc 1034461 cgcactgtct gtcaattgtc attccgggaa ccgataaagg cagtccggct tgaagggctg 1034521 acagtctggc caggttgccg cctctgccag tagcgtttcc gagaatgacc tcgtcaactt 1034581 gatcctctag ctttcggctg agacagcgga tgatgggagc cgccaaatcc tccggcagga 1034641 agggcttcag cagtccgttt tgatttccaa agatcgttcg ttttgcatca acaataaccg 1034701 cattcattta tactgtacac tctcttccag ccattttttc actctggaac gggcaatttt 1034761 tccgctgctc gtttccggca agctgtctgc aaacacccat tttttcggaa ttttatagga 1034821 ggctaatttc tgtttacacc aggctttcag tgttctggca ttagcgtttc caagaatgac 1034881 agctacagcg atttctcccc aatactcgtc gggaatgcca acgacagccg cgctttcaac 1034941 ctctgggcag gcgagaagca cacgttcaat ttcttctggg aaaatattta atcctccgta 1035001 cacgatcatc ccgttttctc ttcctgatat gtatagaaag ccctcttcat caacgtagcc 1035061 catatcatct actgtcatcc attcatctgg tgtgctgccg ttcacatagc cggaaaacct 1035121 catcgggctt ttgacaaata tttttccgat ttctcctggc tggcagcgtt ctcctccagc 1035181 gttgcggatt tcgatccgga cattatgaaa agggcggccc gctgaatgcg gcttccgttt 1035241 gctgtcttcc ggtgaagaaa acgtcacaaa actaagctct gatgtgccgt aaaaatcgta 1035301 cagcttgaga tgaggccatg cagcggcaag cttcttcttg gattctgccg gccagtctgc 1035361 gccggatgaa atgattttga cgggactgtc gggaaaaccc tcaatccttg cgagggcgtc 1035421 tgtcatcgtc ggtacggtat agagaacact gatggattca cggcacagcc attccttcgc 1035481 tttggcagga gaaaactttt tcagcaaaca aacggttcct ccgagaaaca aagtgctgac 1035541 agccccatat aggaagtgag aggacattaa cgctccggga atcagaacct tatcatctga 1035601 tgaaatcgaa aaatctgttt ctgtacaggt aaagctctcc atccatgagc ggtgagatcg 1035661 cgtaaaggcc ttcggttttc ctgtcgagcc cgacgtaaat cccatataaa aagggtgctc 1035721 cggatcaatg gtaggcaagg gatcagcggc tgcctcagaa atatctgcca tacagttatc 1035781 cagcaataca acaggtgtct ggctatctgt cagtttgttt ttgaaaaagg ctaaagtaac 1035841 cacaagatcc gcattgctta tggacagccg ctccttacat tcagccgggc tccagcgtgt 1035901 gtcgatggga atggccgtac atccagccgc tgcggctccg gcaaacagct gtaaaaacgc 1035961 gagactattt gggagcagga tcgccacacg attcggcatg ctcggctgtg accgcagcca 1036021 atttgcggtt tgagagacaa gccgatccca atcatggtac gtgatttgct ccgattcagt 1036081 ctggatcgct acacggccgg gcgatgtttc ggcagtagat gaataggtat gagtaattgt 1036141 catgtattgt catcctcctt ttgtaaacat cgtatcagaa agagacaagg cttgagtgat 1036201 ttttatcgcc agaaatgcag atacagccgc ttttatcaaa tcaccaggca catatgcaag 1036261 gctcatgaag gcggcctgtg acaaatcaat atgcatgata aaagcttgta ccggtatacc 1036321 aagcagataa ataaagatga tgccgaatac gatatgagtg aaaaagagac gcaatactgt 1036381 caccttccgc agcctgttag cggctaaact gatcagccat gaagcgaggg gataagcaat 1036441 caaaaagcct gcgctcggtc cgaaaaacac accaaaaccg cctcgtccgc cgggcaacag 1036501 cggcgctccg aaggcgacga gcagcaaaaa gacaagctgg cttaagaaag cagactttgg 1036561 cctgagaatg ctgcctgcca acatgacacc aagcgtttgc aatgtaatcg gaacgggtgt 1036621 aaaggataag aagagagggg gcataaagcc gagcactgcc atcagcgcgg tgaaaatcgc 1036681 aatatgcatc atgtcgatta atttcagcat gtgaaatcct ccaaaaagta atcaaatatg 1036741 gttatacaat aaatgcaggt aattattatg tcaactgatt tttaatttaa gtttacataa 1036801 tgaacgcaaa aaaaccggcc gtatggcaga ccggtttttg atggttattc ttctgtcagg 1036861 atgacaagcg aatcaacgga agcggccaca tgggaaacgg cgcggctgac ttcctgaagc 1036921 cctccaagaa aggcttgcag atcgacgtcg attttgcctg attgctcttt gctgattttc 1036981 atgctgtgga cgatttcatc gaataagcgg ttaatttgcg tcattttttc tttactttcg 1037041 ctgactagct cattcacgtc tttgatatgc ttggatacaa tgttgatttg tgtattcgta 1037101 ttgttcacaa gctcagaaac agtagagacg gtttttttcg tatcctcaga aagcttccgc 1037161 acttcatttg ccacgacagc aaagcctttg ccgtgttctc cggcgcgggc ggattcaata 1037221 gatgcattga gcgagagaag gtttgtttgt tcagctatgc ctgtgacgat gccgaagatt 1037281 ttttcaattt gctgcgcgat ttcatccagc ttgaccattt ctttttcgat ttggacaagg 1037341 cttgtgtcaa ttttgttcat ctgtttttgc tggacttcta gctctttttt tccgccgatc 1037401 gacttttctt caacagtgct ggatgttaca gtgccggctt tggatgcttg agaaatgcct 1037461 tcagatttgt ccacaagctc ttgaactgat ctgcttgttt ctgaaaacag attggcaatc 1037521 gatccagagg tttcttgaat tttctgatga agaaggtttt tcttttcttc ttgttcatca 1037581 cgggtctggt tgtactcgct ttgaaacgct tcaaggacaa gctgctgttc taagttcaag 1037641 atttttgttg ttgctttaat ggcttttagc agttcttgct gatttgtaat ggacgcttca 1037701 taaatgtcaa tcattgacaa aaggagctct tgaaacgcac ccatatacca ttttggcaaa 1037761 aggccgattc ttaaatggat ggaggcgatt cggttacgct tttcaataaa ttcatcatcg 1037821 ataacgcctg caaacatttc ctgaatatgc cgttttaacg tttgttttaa gcggtcaact 1037881 gagctgtgat cattaatgat atccatcaat gagctttcat ggtcaaggtt tttataaaac 1037941 gcatcgacga tatttacgat attttcttga atgagtggct gaagctgctc taacacataa 1038001 agctcagcat ctcccaacct gaccattttg agctgttttt tgacatctgc atgtttgttt 1038061 gtgagctgaa tgcggttttt ttgttgtccg tttgaatctg aaaagtaagc tgtttcttgt 1038121 tttctgtctt ttttaaataa caatacaatg atcccccttg ggaaaaatat aatttttact 1038181 ttttggcttt ttaagccttt ttctttttta tcggccaagg gaaacatgaa tgaagctgca 1038241 gatgaaaaat atttgaaaaa acgttcatta aaatgaacgg tttaatcgag atctatttgt 1038301 tttaatggtt taatggccgg accctctaca acttcgccag atggcttaaa gcgtgatccg 1038361 tggcacggac aatcccacgt atgctcactg tcgttccact cgacctcgca gcctaaatgg 1038421 gtacaagtcg tatcaacgag atggaggcag cctgtctcat cacgaaatgc tcccgctcgc 1038481 ctgccgttta tggtgacggc tttcccttct cctggcgaaa tgtcttcaaa ttggacatca 1038541 ggcttttcaa gctttccttt tatcaaatgc ttggcgacat ctgcattgta ggaaatcact 1038601 ttctgcaacc cgggattcag atggaaacgg gacggcgtga aaatgctttc gtatgggttt 1038661 tcttttttct ccacaaggtc tgacaataaa gtggctgcga ctgctgagga cgtcatgccc 1038721 cattttttga acccggtcgc tactagaata ttgtcctcat tttccgacat cggcccgata 1038781 aacgggattt tgtcgatcgt cactagatct tgggtggacc aataatatgg aatgctttcg 1038841 atgccgatgg tgctttcggc cagttgtctc agtgtttcat aatgtgtaga catggctttt 1038901 ccctggcctg ttttatggct tactccgctg aagagaatca gcttttcacc gtttacaacc 1038961 gtatagcgga gcgccactga cggctgatcg atactcaaat acatgccctc gggatactcg 1039021 atcttcggct tgatggcaag gacataagat ctgtcggagt acattctcgc agcatataat 1039081 ccgcctccgt cataaaaagg gaagtgggaa cagcatatga taaagcggct cttaatggcg 1039141 tgccggcttt ttgttaccac ttcgggcctt tcgccttttt tgatatcaag cgcaacggtc 1039201 tcttcataaa ttcggccgcc tttttgaaca atttgctcca gaagcgcttt taagtattga 1039261 agcggatgaa attgagcttg attcttcatg acaagcgcca gcttagaacc taagggaatt 1039321 ggaagatcct tgataaggtc tctttcaatt ccgagctttg tgtatgcctc atgctcggtg 1039381 tggatttttt gaacagcgtt ttcatttgcc gtataaagat atgcgtcttg ctcgatccat 1039441 tcacaatcaa tttgatgttc atccacaatg ccttttatgt aatcaattgc gttttggttt 1039501 gcttcataat aaagcctcgc atggtttaat ccgaaatggc ggataaattc gtcgtatatc 1039561 atgtcatgct gtgcggtaac tttagcagtt gtatgcgcag tggttccgtt aagaacctga 1039621 tttgcttcaa tcaaaacgac acggaagcct ctcttcgtaa gttcatatgc cgttgtgatt 1039681 cccgtaatcc cgcctccgat aatggtgacg tcacattcag tgtcctcttg aagcgcagga 1039741 aaagaaggca ggtcagttga tgttttccag tatgtttcag gtgcttcctt tgcaaaatgt 1039801 tgattagcca agccgttata cctccaatca gatttattct taatttttcc atattctatc 1039861 ttttcataca taggaagcag gcattgttca taacataata aggttgaaaa ggagtgattt 1039921 cattggcgaa tcaaaaaaag aaaacattac cgcctcagca ccagaaccag cagcctggtt 1039981 ttgaatatct gatggacccg cgtccggttt ttgataagcc gaagaaagcg aaaaaattag 1040041 agggcaaaac cgctattatt actggaggag acagcgggat tggacgcgct gtctcggtgt 1040101 tattcgcaaa agaaggggct aatgtggtca ttgtgtattt gaatgaacat caggacgccg 1040161 aggaaacaaa gcagtatgta gaaaaggaag gggtaaaatg cctgctgatt gcaggagatg 1040221 tcggggatga agcgttttgc aatgatgtgg tcgggcaggc aagccaagtg tttccatcca 1040281 ttgatatatt ggttaacaat gcagctgagc agcatgtcca gcccagcatt gaaaaaatca 1040341 ccagccacca gctgatcaga accttccaaa caaacatttt ttccatgttt tacttaacaa 1040401 aggcagtgct gcctcattta aaaaaaggga gctctattat taataccgct tcaattaccg 1040461 cctataaagg caataaaacg ctgatcgatt attcagcgac aaaaggcgcg atcgttacgt 1040521 ttacaaggtc cctttcccag tcgcttgttc agcagggcat acgggtcaat gcagtggcac 1040581 cgggtcccat ttggacaccg cttatcccgg ccagctttgc cgcaaaagac gtggaagtgt 1040641 ttggttcaga cgtgccgatg gaacgcccgg ggcagccggt cgaagtggcg ccaagctatc 1040701 tataccttgc cagcgacgat tccacatacg tcacagggca gacgattcac gtcaatggcg 1040761 gaacaattgt gaacggataa taaaaagcca atccttgaag gattggctta ttcgctctgc 1040821 ttgagcgctg catattcttt agagagcgta agaaacgcat ctttatcttt ttcgtccaag 1040881 gctttgttaa tttggtccgt cagcatggca agccgacggt tatacaagga ttcatcgagc 1040941 accatttgaa tgtaaatatc cgtcattgtg acatcgaatt cttttgtttt ttgcgtgttg 1041001 cgggacttca tgagctcagt gtacgatttt ttctctttca taaagaatcc ccccaatgcc 1041061 ttttttatag tatatggata acggtcgaaa aaatcaataa atttttataa tttttagaca 1041121 actaatactt ggcaatctat cgacatatcc tgcaaaatgc cgtaaaccgg caagtcttat 1041181 gaaagtaaaa tcggtttatt actagtcatt tagtaccatt aaatatcatt aaaagatgat 1041241 tttatcttaa atgttaaaaa aacctgtcgt tttacaaaaa cagatgatag attattagta 1041301 taaattttgc agaaaaagga tggaggccat aatatgagtc agaaaacaga cgcaccttta 1041361 gaatcgtatg aagtgaacgg cgcaacaatt gccgtgctgc cagaagaaat agacggcaaa 1041421 atctgttcca aaattattga aaaagattgc gtgttttatg taaacatgaa gccgctgcaa 1041481 attgtcgaca gaagctgccg attttttgga tcaagctatg cgggaagaaa agcaggaact 1041541 tatgaagtga caaaaatttc acacaagccg ccgatcatgg tggacccttc gaaccaaatc 1041601 tttttattcc ctacactttc ttcgacaaga ccccaatgcg gctggatttc ccatgtgcat 1041661 gtaaaagaat tcaaagcgac tgaattcgac gatacggaag tgacgttttc caatgggaaa 1041721 acgatggagc tgccgatctc ttataattcg ttcgagaacc aggtataccg aacagcgtgg 1041781 ctcagaacca aattccaaga cagaatcgac caccgcgtgc cgaaaagaca ggaatttatg 1041841 ctgtacccga aagaagagcg gacgaagatg atttatgatt ttattttgcg tgagctcggg 1041901 gaacggtatt agaaaaatag gaaggagctg accgaacagg gcagctcctt tcataaagct 1041961 atgccgtcgg aattcctccg gtgatgccat atacctgaga tgtcacatag cttgaattct 1042021 ctgaagctag aaatacataa acatcggcca attccactgg ctgcccagcg cgatttaatg 1042081 gagctggcgg cgtgccttgt ccgaatttcg ggatgttttc cgtcggctgt ccgccggaaa 1042141 tttgcagcgg tgtccaaatt ggtccgggcg caactgaatt tactctgatg cctttggaag 1042201 caagctgttt tcccagtccg acggtaaagc cgataatggc gtttttcgtt gctgcgtaat 1042261 ctaacagcat cgggcttgga ttatagcctt caactgaggt agttgtgata attgaagctc 1042321 cctccggcaa atacggaagc gccgctttta caacccagta aagggaaaag acgttcactt 1042381 caaatgtttt atagatttgt tcagtaggca gatcttcgat gttttcgacc gcttgctgtt 1042441 tgcctgcaac gagcgctagc acatcaagtc cgccgagttc gtgatgcgac tgtttgacta 1042501 gatcttggca aaaggattcg tcgctcaagt ctccggggat cagcactgct tttcggcctt 1042561 ctgcttcaat cagctctttt acctcttcag catctggctg ttcctcgggc aagtagttaa 1042621 tagccacatc ggcaccttct ctggcgtaag caattgcggc agcgcggccg ataccggaat 1042681 cgccgcccgt gacaagcgct tttcgacccg ttagtttacc tgatcctttg tagctttttt 1042741 ctccgcaatc agggacaggc ttcatgttct tttgcaggcc tggcggttct tgatattgtt 1042801 cgggaaattc atcatgaaaa aatgctttta taggattcgt aagatttgaa tcagacatca 1042861 gcaacgctcc ttttctgttt ggtgtacatt cgtatgtgta cccctgagca taagcagaaa 1042921 aacatgtttt ggcagtttga atagtgaagg aaaaagaaaa caagaaaaaa caaagccttc 1042981 ttccatattt atcttgtcaa ataagactat atgaattatg ataaattcga gctataaatc 1043041 aactaaatat tgggtgttgg gagagtgaat cgtcatgaaa aaagcggcgg cggttttgct 1043101 gtcactcggt ctcgttttcg gtttttcata cggagctggc catgtggcgg aagccaaaac 1043161 aaaggtgaag gtctataaga actgcaagga gctaaacaaa gtatacaaag gcggagtggc 1043221 ccgcacatcg aaggtgaaaa acaaaggcgg aaaaacgaag tacaagcctt acgtttctaa 1043281 ggcactttac gatgccaata aaaacaaaga ccgcgataaa gatcttatcg cctgtgaacg 1043341 gtaaataaga aaaagcaatc tggtgtccag attgcttttt ttatgcttag gccgcctgat 1043401 cggccgcagc gcttttcgcc ttccttgtca taaggctgac tgccatcatg accgtgatat 1043461 tcaaaagcag ggcgacgatg ccgacattca agtcttttgc ggcttgcggc agagccggaa 1043521 ataaagtgcc gatcgtcgtt tccgtcattg taatataagt aactgctccg acacctgcaa 1043581 taatgccggc gaaagctcct tgctttgtca ccatattatg cttgagcagg ctgaacaaaa 1043641 gggcggggaa tagctgtgtg acaaggctgt agcccatcaa aagcagcgta acgatggtat 1043701 tcccgccttt gaaggtaaaa tacaccgaaa tcagcgcaat caccggcact aaaaacttag 1043761 caagcgccga tacttgctgt tctgtcgtgc ggggcgcgat taccttgtac acattttttg 1043821 caaacagtgt ggaggcggac attaagatca tagaccctgg cacaagtgct gtcagcagtc 1043881 cggcagcacc gataattccg acaaaccaag ggtcaaatgc ttgcagagac agtctcaaaa 1043941 gcgacaaatc cccgtctgcg ccattcagat ctggaacttg caggatagcc gcaaagccga 1044001 cgaaaaggac gaagagcagg accagctggt acaaaggcat gatgatggcg tttttacgaa 1044061 acacttttgg gttttcggct gaatacgaag cggaaaacgt gtgaggccac atgtaaaaac 1044121 caagcgctgt caagagtacg gttgaactga accaggccac actttgtccc gattcgggga 1044181 gcgtaagaaa gccaggcttt gccgtttcaa tctgctgaaa catgtcttga aatccgccgt 1044241 agtaatgaat tggcaaatac acacctaaaa acagaacgac aaccagaatc atgatgtcct 1044301 tcacaaccga tatccaggca gacccgtgaa tgcctgaaac cataacataa accgtgatgg 1044361 aaacagcgcc gatccagatg gcagcggtcg gggtgatttt gccgtacgag gtttccgata 1044421 caatcagccc gaggcctttc agctgcagta caagataggg aatgagtgcg gcgatgccga 1044481 ccagtgaaac gagaatgcca agcagcggac tgttgtattt ttttgtgaaa aaatcagact 1044541 gcgacatcag tttatgctgt ttcgcgtacg tccaaactgc tggaagaagc cagtaagaaa 1044601 ggatgtaggc cagacatccg taggcgatga tataaaaggc tggaccgcct tttccgtagg 1044661 cccagccgct gccgccgaga aacgtaaaag tagtataaat ttcgcctgcc atcaaaagga 1044721 agacgaaaac agttccgaag ccgcgccctc cgaccgtcca ctgctccagg ttcatgtctt 1044781 ttcctttttg ggcgcgtata ccgagaaaaa tactcaagag caggacaccg aagatgatga 1044841 tgagagctgc attcattctg cttcctcctt tttattttcc ttgtcgagga catacacaat 1044901 cgccatcagc gcagaggtca aaagagccca catcacaata taggcaagaa taaacggcat 1044961 gccgaacaca tagggggtca ccttatttgc aaaagggatg ccgagtaaga ttccgataaa 1045021 gggtaaagcg gcaagaacgt gaatcagttt catagaatcc tccttctatt taggattgag 1045081 gtgtacaagc ctaagcgtac tgaaaatgat gtcgcagata tcgcagcaca tgtcattttt 1045141 tggagtgaaa ggctgtggtt cgaattataa ataaatttat tttgtttgta tagtgtgaat 1045201 tgtctgaaat taatgctctg aatcgcccga agagggaacg ggcagtatga ttcaaaaggc 1045261 tcagagtctg tctggggcaa atagatagta tgttaataat tcgctgacct gctcacggat 1045321 tcgcggatta aaatagcgat ggttttcttc ataaccgtcg atgacaaatg tatagagtgt 1045381 aaaggcctca tcgcgttccg tctcgcggat tgcaattttt cttttcctca gttcttttct 1045441 gacctccatc aaatcctttt gtgctatttt taatgattcg ctgataagct gtttataagg 1045501 atgcttcaat tttaatgtgc tttcttcaat tccggcgaga tcacggttaa aaatcgtaat 1045561 ggccatgggc aaaaagagag cccgttcaat taaatcgtat atttcctcct gcagatttgg 1045621 catattgact ccttctttct aagggaacgt ttgttctatt tgtattctat atcggctggt 1045681 gaaatgtttc aagacagaaa aaatcaccaa aactttttag ttttctgctg ataatgtgta 1045741 gaataaggat agacaaaccc ggtaaggagt ataaatgttg gagcattttt tatcctattt 1045801 gacacaagaa catttaactg aattatttca aagctatagg gctttcggtc cgctcattgc 1045861 tgtgctgctg cctttaattg aagcatttct cccgtttttg ccgctgatcg tgtttgtggt 1045921 ggcgaatacg aactcgtttg gcttgtggga aggattcatc ctatcctggg cgggatcaac 1045981 tgctggttcc attctcgtct ttttgattgt ccgtcaatac ggacagagaa aattgcttgg 1046041 atttatccgc agtcatccgt ctgtcagaaa gctgatgtta tgggtggaaa gacacggctt 1046101 cggtcccatg tttcttctgc tttgttttcc atttacaccg tcagccgcgg tgaatgttgt 1046161 tgccggtttg tcaaggatcg gaacgcggcc gtttattttg gcggcagcct cggggaagct 1046221 tgtcatgatt tttatgatca gcttcatcgg atatgatctg cacgcgctga ttacacagcc 1046281 gattcgaacg gtcatcgccg tattggtgat cactgtctta tggtatgtcg gcaaaaaggt 1046341 ggagcggtat ctgcatgtaa gagccagtca gcgtgagcat gatggaggga gacagtaaca 1046401 tgaaaaaacg gttttggttt cttgccggtg tagtgtccgt tgttctcgcc attcaggtta 1046461 aaaatgctgt ctttattgat tacaaggtag aaggcgtcag tatgaacccg accttccagg 1046521 aaggaaacga attgttggtc aataaatttt cgcatcgatt taaaaccatc catcgttttg 1046581 acatcgtcct ttttaaaggc cctgatcata aagtgctgat taaacgggta atcggcttgc 1046641 ccggtgaaac gatcaaatat aaagatgatc agctgtatgt gaacggaaag caggttgctg 1046701 agccattttt gaagcatttg aaatctgttt ctgccggcag ccatgtaacg ggtgattttt 1046761 ctttgaaaga tgtgacggga acaagcaagg tgccgaaagg aaaatatttt gtcgttggag 1046821 ataatcgcat atacagcttc gacagccggc attttggtcc gataagagaa aaaaatattg 1046881 tcggtgtgat ttctgatgcc gaataaaaag acgctaattg aagaggcgtc tttttgtatg 1046941 ccgtttggaa aaatgtgttg aagaaaaatt tgtaaggagc tataatcaaa attgttacct 1047001 gtgtaacaaa atttatatat ttttttgact ggagggccgt ttttattggt ttttgttcgt 1047061 ttttcatgaa acaaaaggag tggtgaatga tgatgaaata tgaagcagtg attataggag 1047121 gagggccggt tggatttatg ctggcttctg agcttgcaat agccggagtg ggaacatgtg 1047181 tgattgaacg gcttgaaaaa cctgttccgc attccaaggc gttgacgctg cacccccgaa 1047241 cgctggagct tcttgagatg agagggattt tagagcggtt cgtatccaag ggaagcaaga 1047301 tacctaccgg acatttttca atgctggata cccgtctgga tttttcaggc ttggatacga 1047361 gctgtcctta cacgcttttg ctcccgcagt ccaaaacaga aaagcttctt gaagatcatg 1047421 cacgaagcct gggaacagag gtgtttcggg gtgccgaggc gctggcggtt acgcaaaacg 1047481 gggaagcggt ccaaacaatt tttaaggatc gggacggcag tgtacggacg atcacaagca 1047541 agtttgccgt tggggcagat ggcgccggga gtaccgtccg gaaacaggcg aaaattgagt 1047601 ttccgggaac agacagcact gtcaccgctg cgcttgggga tgtggtgctc ctttctccgc 1047661 cgccgtcagg tgtgctgtcc ctttgcacaa aagagggcgg tgttatgatt gttccgttat 1047721 ctccagaccg ataccgtgtc gttgtgatca gcccttatcg cacacaaacg ccgaaagatg 1047781 tgcctgtgac tgaggaagag ctgaaagctg acctcctgcg aatttgcgga actgacttcg 1047841 gtttaaccga cccttcgtgg atgtcgcggt ttgggaacgc cgcgcgccaa gcgaaacggt 1047901 atcgggacgg cagaatcttt cttgcgggtg atgccgcgca tattcatttt ccggcgggcg 1047961 ggcaaggact gaatgtcggc cttcaggatg caatgaacct cgggtggaaa ctggcggcgg 1048021 ccatcaaagg ctctgcgcct tcttggcttt tggacagcta ccatgatgag cggcatccgg 1048081 cagcggaagg gctcctcaga aacacggagg cacagacaaa gctgatcgat ttcactcaag 1048141 caggcctcca tttgcgaagc atgatgtcgg agctgctggc cttccctgat gtgaatcgat 1048201 atgtagcggg gcaaatttct gcgctcgatg tcagatatga agctgatcgt accatgccgc 1048261 cgaatcgttt gaacggggca aggctccctg acatgaagct gattctttcc gacggcaatt 1048321 cggaacggct gtacagcttt ctccaaaacg ggacattcgt tttgctgtca ttgaggcagg 1048381 aagctgatga tcatatcgaa gtaaaaggct tacgtacggt aaccgcctcg cttgcagaac 1048441 cgaatgaaaa gttgcggaat gtgcatacca tattgattcg tcccgatgga catgtagcct 1048501 gggcggtgga tgcatcagcg cccgattgtt ccgaggtgat tcaaaaaggg atcagccgct 1048561 ggttttccgt caccagccga gtataattca attcgattgt ttcatctgta acaaaacggt 1048621 atgatagaag aaacaatcga atgaaaaagg atggaaaacc cgatgaacac agatcatacg 1048681 aaacgcaatc tttttgaatt gtatgcggag ctcattcatc agcaggagaa atgggagggg 1048741 cttattaaag cctttttatc tgacgaattg aggaagctgg atgtagagca cgggagtaaa 1048801 tctcaattga cgatgacaga aattcatgtt ctatcctgtg tcggggacaa tgaaccaatt 1048861 aatgtcacgt cgatagcaga aaaaatgaat acgacaaaag cgactgtatc acgcatcagc 1048921 acaaaattgc tcggcgcagg cttccttcac agaacacagc tcagcgataa taaaaaggag 1048981 gtctacttcc gattgacgcc tgctggaaaa aagctgcaca gtttgcacaa atattatcat 1049041 cagaaggctg aacagcgttt tctgtcattt tttgaccgct ataccgagga agagattctt 1049101 tttgcggaac ggctgtttcg ggatctggtg acaaaatggt atccgtcgtc agaagaaatt 1049161 gaaggggggc ttcctagcat ttttaaataa aaaacacgca ctgcggtgcg tgtttttcgc 1049221 tttgcggccg cctcgagaat tctttcattt caccctctgg cagcactcac ttcaaatctg 1049281 atccattaac aacgaaatat ccgcttatat ttcctcatct cgatggtttg cgaattaaaa 1049341 gttcttgaac ccttttttca actaggcact actgccgctg attgagctct ttttgtcttt 1049401 tttttcacca tgaagatggt gaagcaggcg ataaaacggc ggcagcaggg caataaccag 1049461 aatgacgcga atgacctgaa ccgcaacgac aaaggtggaa tcagcatgta aggtaactga 1049521 cgtcgtcgcc atctctgcaa tcccgccggg cgcaaatgcc agaacagaag tgatgagcga 1049581 aattcctgtc agctcggaaa cgatcacggc gctcaaaaac attgctgcga ttaaaccgac 1049641 ggacgagaca aacccgacga tgataatacg ggtgacgccg gcaaacatgc ttttgtacat 1049701 cttagagccg atcgttgccc cgagaaatac ttgtgataca tggttagctt gtgacaacca 1049761 ccatgccgtc atgtcgtgcc ctgtcaccgc agctccgcca acatgtacaa ttgctacacc 1049821 gagcatgctg ccgagcagcc atggagctgg aaattttaaa aatttcgcag ctttgcaagc 1049881 tccccaggca gcgagaataa gaatgacggt ccacaaaacg ggagcgagcc taaaatctgt 1049941 cgttgcagaa gaaatcgtct ctgctgcggc acttgcggta cgatcttgtt ttgtatagat 1050001 cagaatgact aaaaacggaa tggaaagcac cacgagcagc acacgcatca tttgaacgag 1050061 gctgactata gcggtattgg cgcctacttc ctgtgcgatg ctcggcatgg cggaaagtcc 1050121 gccgggagcg gtgccgacaa agctagtcat catatccgtt ttgctgaaac gccaaagcac 1050181 atatcctgac agcatggcca gcaggataga caatatcagc ataacgccga ctgaaaacca 1050241 atggtctttg agaacagaga gaacggataa attcagcttt tggcccaatt cgatgccgag 1050301 gatcatctgc ccgagggcga gccatcgtcg gttaattcct ttttggtctg gtgccatcat 1050361 cagccatgcc ggccgtatca tggcgaggca gcaggcgaca atcagtgttc cgatcatcca 1050421 tccaattgat attccggtta atgaaagaat aaaccccccg gctgcactga ttgcgataaa 1050481 ccatagatct ttgaggagat tttcgtcttt cttcaatgta aaacccttct tcctttttca 1050541 cgtaacactc caattgttca cgtagtgaat gtatttatta ctatagtata tttttgttga 1050601 taaagaaatt atgaattatt ttctataagc gattcacttt tcttatgacc ttgtgttcga 1050661 gcttttctat tgtgtaagtc agagataaac ccgctgtcag cagacacacg gcaagagcgt 1050721 aaaaaatcac ttctccgcca aatgatgtca ggatcagccc gcctgccagc ggtccgattg 1050781 agcgggatat atcccaatgc agaccataga cagcataaaa ccggcccagc aaatgaggcg 1050841 gcgccaattt cgatatgaag gtctggatgt gggttagccc gatgctttca ccaaccgtca 1050901 tcaccgctgc cgtcactaaa agcattgtca gagaggttga gcatgcaaag ccggctgccg 1050961 caagggagta gcaaatataa gtaatgaaga ggatcgtttt cattgaaagc ttttcggtcc 1051021 ctttgacaag aggtacttgg agaacacagc tgaataaagc ttttgctgct gaatagatgg 1051081 tcagcatgga cagataatca gaaaacatgt ttttgctgaa cagcctgtat gttgtttctg 1051141 tttgtgcata taacatgctg atggggagag aaagcagcaa aagaagcagg acaggcctgt 1051201 atattgtaaa gctcgcggac attttcgggg taacagctgg gtgtagcggc tttgtctcag 1051261 gcagtttcag tgcagcgatc agaaagtaga taaacaatgc tgcagcatct aatgcgaata 1051321 tccacacggg gttatgattg tacagcagca tccccactag cggtcctgcc gtcagacccg 1051381 tcgaatagat cgcattgatg accgcaaaca cttccgaacg tctgctttcc ggcgtgcttt 1051441 cagcgatttg ggcgcgggaa gcgggaatgt acaacgatct tccgatgcca ttcatgacat 1051501 agagaatagc gaaaacatac gcatgctcag caaatacaaa ccctgtcatt gccgctgatt 1051561 gaagaagcaa tgcggtcaaa atcgctgtgc gccgcccaag ccgatccgtc acccgtcctg 1051621 cagcgagcgt caggaaaata tcagcaaatg gctgaaggct gatgatcagc attggcatca 1051681 tgatactgcc gtttaattgt tcatgcagat acagcaccat aaaaggtccc atcattgcac 1051741 ctgtcaggct tgtcagcaat tcgccgaaaa agcggagccg aacgggagcg gtatatctcg 1051801 attttataga gtgaaaactg gtcaacatgt gatcgccgcc tttcgctgtt tgatatagta 1051861 gtagtgtata gaaggggcgg cggcccaaaa agtgaagaaa agaagagata aaagttcccc 1051921 ttttgtcggg aggtgcgggg attgaagctg atagagcact acgtggcgct tgtaaaaaca 1051981 ggctgcgccg agtatgggca aatgaacgaa atgacgctca ctgagattgc cgactgttta 1052041 ttttgtacag aaagaaatgc aaagctcatt ttacataagc tggagaacag caattggatt 1052101 atccgggaaa gcggggcggg gcgcggccgc aaatctaaaa tcgcgtttct tcggaggcct 1052161 gaggaactgc ttcttcaaac tgcaaaggaa tataccatgt caggaaagct taaaaaggca 1052221 aaggagctgc ttcagcagta tcagtccgcg tttccagggc ttcaaaacga atataacatg 1052281 tggctatcag aggtattcgg atttgtgacg gagacaggcg agaatggggc gaaggatgtc 1052341 ctgcggctgt tcatcacgcc tgaatctgtc agcagtttgg atccatgcca aatatttttg 1052401 cggtctgagg gccatttcgt caaacagata tttgatacac tcttcacgtt tgattcggat 1052461 atgcaggagc cgaagcctca tttggttcat ggatgggaag aggtcggaaa aaaacaatgg 1052521 agattttttc ttcgaaaagg tgtgttattt cataatggac agccgctgac atcgcgggac 1052581 gttgcgttta catttcagcg ctttttggaa ctggctgaca acccgtataa atggcttctg 1052641 cacggagtga aacaagtctt agaaaagggc ccttattgtg tggagctcat actcgataag 1052701 ccgaatgcgc ttttgccgta tgctctttgt gatgaacggc tgtccatact gccggcagaa 1052761 cagggcggcg ggaaaaatgg aacagggcct tttcagatga atcagcaaca tagcgggatg 1052821 cttgtgcttg aagccaatga gcgctacttc aagggacgcc cctatttgga tcgcgttgag 1052881 tttgtgtttt ctgagcaagc cggagagatg aacggtttta ccattcaaga aaaacaaaca 1052941 tgtcctgagc agcaaactgt ctttgatgag cggcatgttc agtatttgtc gcttaatctg 1053001 aaaaagaagg ggcctcttca gcaccgaagc tttagaaaag cgctccggct gctgatttcc 1053061 tctgaacggc tcgttcgtga agcgggaggg caccgaagaa ttccggttac gtcctttttg 1053121 catccgagtc cttttgagtg ggagggcgtt tcgccatctg aattgttgaa aaaaagcgga 1053181 tacgagggcg aaacaatcgt gctttatacc ttttcggaaa cggatcatcg tgaggacgcc 1053241 gaatggattc aaaatatttg cgcccagcac ggtatcaggc ttacacttca attctgtgat 1053301 gctgctgatc tgcgacggcc ggaaatcgtg cagatggcgg atatcattca tgacagtgcg 1053361 acgttttatc aagacagcga gtttggtttt ctgcatttgc tgctgtcgga gaacagtttc 1053421 ttgtatcagc atctatctga aaagctgaca cagatttgct caggaatgac agagcggatg 1053481 ttttccatgc ctgaccgctg ttcgagaatc aacatcctgc gtgacattga ccggcagatg 1053541 atacaggagc tgaacgcgat cccgctgtat caaaatgtgc tccaggtgac atcaagtaaa 1053601 aatgtaaaag gcctggtgct tgatgaagag ggatggattg atttgtactc cgtatggctg 1053661 tccaaataaa aagagggttc ttttttgaac cctctttttt acgctgccat gctgcggcat 1053721 tgttcagcac aggtgaagca ggctttcgca catgcttggc aatgatcatg atcgtgcttt 1053781 ccgcattcag tgccgcatgc ttcacaaata tcggcgcaaa gtgcacaaat ttctttcata 1053841 aacgggctgt ccgtttgcat ggctttgacc gccagcgcgc aaatatccgc gcattccctg 1053901 tcaagccgga tgcatccgct gagatgatgc tgcacgcttt cttccaagca tttagtgaaa 1053961 caatgattgc aagccttcat gcaatcgatg caagcctcaa tacaagcctc agaatattgc 1054021 tccatggttg attccccctg tatgacagta tatggtttta tgtttcacgg ctgcatttga 1054081 aaaaaacagg ggagtgtgtt tttagctaag gggatatgta catataccct gaatgggtat 1054141 atctaacgtt ccatcagata gtataggaac cagacagcgt gattttgttc atcacgtgct 1054201 gcgcgcgtaa agacgccttt cgcttttaag tttgacgttt cctcggccgc acgcaagtaa 1054261 aagtcgacgg tttcttgttc atctttaaaa gcggcgtcca gtcctcttgt gaaattgtcc 1054321 gggcattctt ccgtttgttt cggcatgatg tgtttgccgg taattgaacc atacagtgtg 1054381 gaaaattcac ggaggtggcg aatctcgtca cgcctgattt cttcaatctg ttttctgacc 1054441 tcatcgctgt gggcgagttc ggcaagcttg cggtagcatt gaatagcact gaattctccg 1054501 ttgatggcct tctgcaaatt ccgaatcaaa acaggatctt cccggtatgg caccggatag 1054561 ggatagtagc tgtaatgcaa ggggattcaa ctccattctt aggaattggg cttctgtaaa 1054621 agtatatgtt gggcagggag agatgtgcgg agataatcag ctttttatat gtgaaaaggc 1054681 cgtttttacc aatagatcag attggtcatt ttcgtcaaca ttcgataaaa tatagagaga 1054741 taaaaagaga ggggtcttct aatttgggag cagagttttt agtaggcagg tccgggagtg 1054801 gaaaaacgaa gctgatcatc aacagcattc aggatgaatt gcgccgggct ccattcggga 1054861 agccgatcat ttttctagtc ccggatcaaa tgacgttttt aatggaatac gagcttgcta 1054921 aaacgccaga tatgggcggg atgatacgcg ctcaagtgtt cagtttttca cgattggcct 1054981 ggcgcgtcct ccagcatacg ggaggaatga gcaggccgtt tctgacgagc accggcgtac 1055041 aaatgctcct gcggaagctc attgaggagc ataaacagga gttcaaagtc tatcaaaaag 1055101 cgagtgacaa aagcgggttt accgcacagg ttgagcggat gctgacagag tttaagcgct 1055161 attgtctgga accggaggat atccgccgga tggcggaaag cggaacggct tccgagtatc 1055221 gcggagaacg tgttttatct gaaaagctcc atgacttatc aattctgtat cagcaaatgg 1055281 aaaaaagcct cgcagatcaa tatcttcact ctgaggatta tttgacattg ctggcagagc 1055341 atatcccgct tgcggaagat ataaaaggcg cccatatcta tgtggatggc ttttatcagt 1055401 ttaccccgca ggaattcagg gtgttggagc agcttatggt tcatgcggag catatcacgt 1055461 tttcgctcac agcggacaag ccgtcatatg agcgggagcc gcatgaactg gaattgttca 1055521 gaatgacggg gaaaacctat taccgcctgc atcagaaggc gaaggaactg aatttggaca 1055581 ttacgtataa agagctgagc gggactgagc ggcatacaaa gacgccggaa ttggcgcatc 1055641 tagaggcaca gtatgaagcg cgtccggcca ttccatacgc agaaaaacaa gaagccctta 1055701 ctgtgatgca ggccgcaaac agacgagctg agctggaagg cattgctcgg gaaattcacg 1055761 ccctagtcag agagaaggga tatcgctata aggatgtagc aattcttgcg cgccagccgg 1055821 aagactacaa ggatatggtg aaggaagttt tcgcagatta cgagattcct tatttcattg 1055881 acggaaaagc atctatgctg aaccatccgt taattgaatt tatccggtcg agccttgatg 1055941 ttctgaaagg gaattggcgt tatgaagcgg tgtttcgctg cgtgaaaacc gaactgctat 1056001 tcccgctcaa tgaaccgaag gccaaagtga gagaacaggt cgatcagctc gaaaattact 1056061 gtatcgccta tggtattaaa ggcgaccgct ggacaaaggg cgatcggttc caatacaggc 1056121 gttttgtgtc attggatgat gattttgcgc agactgatca ggaaatcgaa atggaaaaca 1056181 tgttgaatga cacccgcgat tggattgttc cgccgctttt tcagcttcaa aaacgcatga 1056241 aaaaagcgaa gacggttcaa gagaaggcgg aggcgctcta tcgttattta gaagagacgg 1056301 atgtgccgct gaagctggat caggaaaggc agcgtgctga ggatgacggc agaatcattg 1056361 aagcgcagca gcatcagcag gcgtgggacg cagtcattca gctgcttgag gagtttgttg 1056421 aaatgatggg agatgatgag atttctcttg atttgtttca gcaaatgata gaagccggcg 1056481 cggagtcgct tacattttct ctaattccgc ctgcgcttga ccaggtgttt gtcggcaata 1056541 tggatttgtc cagaatgtat ggcacctcct gcacctttgt gctcggggca aacgacggcg 1056601 ttctgccggc acgccctgat gaaaacgggg tcctgtcgga tgatgaccgg gaatggctga 1056661 aaacgattgg ggttgagcta tcctcaggcg gacgagagcg tttgcttgat gagcacttcc 1056721 tcatctacat ggcgttttca agtccgtctg accggcttta cgtatcgtat ccgattgctg 1056781 atgcggaagg aaaaacgctt ttgccgtcga tgatcgttaa gcggctggaa gaactgtttc 1056841 cgcatcataa ggagcgcctg ttaacaaatg aacctgaaca ggtcagcgat gaggaacagc 1056901 tgatgtatgt tgtgaataaa agcgtggcac agtcctttac cgcgagccag ctcaggttat 1056961 ggactcggga atacgacatc agcgacgtct ggtggagcac gtacaatgtg ctgatgagtg 1057021 agcaggacag gctgcaatcg aaaaagctgt tctcaagcct gtttttccgg aatgaagtga 1057081 agcagcttga acgcagcgtg tcgagacagc tctatggtga acgtattcag ggcagtgtat 1057141 cgagaatgga aacctttaac gcatgcccgt tttcccattt tgcgtcacac gggctgcatt 1057201 tgaaggaacg gcaattcttc aagcttgaag caccggatat cggccagctg tttcattcca 1057261 gcttaaagct gatttcggac aggctgcgtg agcaaaagct ggattggcgc gatttaacga 1057321 aggagcagtg cgagctgttt tcctatgatg cggtagagcg gctggcaccg aaactgcaaa 1057381 aggaaattct gctcagctca aaccggcatt attatgtgaa ggaaaaactg caaaaaattg 1057441 tgacacgtgt gtccggcatt ttaagcgagc atgcgaaagc gagcggattc gtaccgatcg 1057501 ggcttgaact gggctttgga ggaaaagggc cgcttccgcc gctgaccttt caactgaaaa 1057561 acggctgtac gatggaactc gtcgggcgaa ttgaccgtgt tgataaggct gaaagctcaa 1057621 aaggcctgct cctcaggatt gtcgattata aatcaagcga caaaggcctt gacttagcgg 1057681 aagtatatta cggattggca ctgcaaatgc tgacgtacct tgatttatcg attacacatt 1057741 cagctgactg gctcgggatg agggcgacgc ctgccggagt gctgtatttc catattcatg 1057801 acccgatgat tcaatctaat ctcccgcttg ggcttgacga gattgaacag gagatcttta 1057861 agaaatttaa aatgaagggc ttgctcctcg gtgatcagga agtggttcgc ctcatggata 1057921 caacccttca agagggacgt tcaaatatca taaacgccgg cttgaaaaaa gacggctctc 1057981 tcagatcaga ctcagcagca gtcggtgaaa aggaatttga tcttttgaca aagcatgtgc 1058041 gccgcacctt ccaagaagcg ggcgaacaaa tcaccgacgg gcgcgtatcc attgagccgt 1058101 acaaaatgaa gaacaagacg ccgtgcacat actgtgcgtt caaatcagta tgccaatttg 1058161 atgaatcact ggaagaaaac gagtatcgcc cattaaaggc tgaaaaggac aagacaatac 1058221 ttgagtggat aaaaaaggag gcggatggca atgaacattc ctaaaccggc agacagcaca 1058281 tggacagatg accaatggaa tgccattgtt tcaaccggcc aggatattct tgtggcagcg 1058341 gctgcgggct ctggtaaaac cgctgtgctc gttgaacgaa tgattcggaa aatcaccgcg 1058401 gaggaaaacc caatagatgt agaccgtctt ctcgttgtga catttacaaa cgcctcagcg 1058461 gcagagatga agcaccgaat cgcagaagcc ttggaaaaag agcttgtaca gcgccccggc 1058521 tcgctgcata ttagacgcca gctgtctctt ttaaaccggg ccagcatttc gacgctccat 1058581 tccttttgcc tgcaagtgct gaagaaatat tactacttga tcgatcttga tccgggcttt 1058641 cggatagctg atcagacgga aggcgagctg atcggggatg aagtgcttga cgagctgttt 1058701 gaagacgaat acgcaaaggg cgaaaaggcg ttttttgagc ttgttgaccg ctatacgaca 1058761 gaccggcatg atctggatct gcaatttctc gttaaacagg tgtacgagta ttcccgatcc 1058821 catcccaacc cggaggcgtg gctggaaagc tttgttcatt tgtatgatgt atcagaaaag 1058881 agcgccatcg aggagctgcc gttttatcaa tatgtcaaag aagatattgc aatggtgctt 1058941 aacggggcga aggaaaagct cttgcgcgcg cttgagctga cgaaagcgcc gggcggcccg 1059001 gcgccgcgtg ctgacaattt tcttgatgat cttgctcaga ttgatgaact gattcagcat 1059061 caggacgatt tcagtgaact atataagcgg gtgcccgccg tctcttttaa gcgtgccaaa 1059121 gcagtaaaag gggatgagtt cgatccagcg ctccttgatg aggcgacaga tttgaggaac 1059181 ggcgcaaaaa aactgcttga aaagctcaaa accgactact tcacgcgaag tcctgaacag 1059241 cacttgaaaa gcctagccga gatgaagcct gtcattgaaa cgctcgtaca gcttgtcatc 1059301 agctatggaa aacgattcga agctgcgaaa caggaaaaat caatcatcga tttttcggat 1059361 ttggagcatt actgtttagc gattttgaca gctgagaatg acaaaggtga acgtgagccg 1059421 agcgaggctg caaggtttta tcaggaacag tttcatgagg tgctcgttga cgaatatcag 1059481 gataccaacc tcgtgcagga atcgattctg cagctcgtca caagcggtcc ggaggagact 1059541 ggtaacctgt ttatggtagg agatgtcaaa cagtcgattt atcgattcag gcttgcggag 1059601 ccgcttcttt tcctctctaa atacaaacgg tttacagaga gcggagaagg cacggggcgg 1059661 aaaatcgatt taaataaaaa tttccgaagc cgggctgata ttttagacag cacaaacttt 1059721 ttatttaaac agctgatggg cggcaaaatc ggtgaggtcg attatgacga gcaggctgag 1059781 ctgaagcttg gtgcagcgta tccggacaat gacgagacgg aaacagagct gctgctgatc 1059841 gacaacgcag aagatacgga tgcaagcgag gaagcagaag agcttgaaac ggtgcagttt 1059901 gaggcaaaag ccatcgctaa ggaaattcgt aagctgattt catcgccgtt taaggtgtat 1059961 gacggaaaaa agaaaacaca tcgcaatatt caataccgag atatcgtgat tttgctccgt 1060021 tcgatgccgt gggctccgca aatcatggag gagctgagag cacagggcat accggtttac 1060081 gccaatttaa cgtcaggcta ttttgaagcg gtcgaagtcg ccgtcgcgct ttctgtgctg 1060141 aaggtgattg ataatccgta tcaggatata ccgcttgcct ctgtgctgcg ctcaccgatt 1060201 gtcggagcag atgaaaacga gctgtctttg atccggcttg aaaataaaaa agcgccgtac 1060261 tatgaggcga tgaaagacta cctggctgct ggtgaccgga gcgatgagct ttatcaaaag 1060321 ttaaatacgt tttacggaca tctgcaaaaa tggcgcgcgt tttcgaaaaa ccactcagta 1060381 tctgagctga tttgggaagt gtaccgcgac accaaatata tggattatgt cggcggcatg 1060441 ccgggcggaa aacagcgcca ggccaatttg cgtgttcttt atgacagggc gcgtcaatat 1060501 gaatcaacgg catttcgcgg cttgttccgt ttcctgcggt ttatcgaacg catgcaggag 1060561 cggggcgatg atcttggtac ggcgagagcg ctcagcgagc aggaggatgt tgtccgctta 1060621 atgacgatcc acagcagcaa agggctcgaa tttccagtcg tgtttgtagc aggtctcggc 1060681 cggaatttca acatgatgga tttgaacaaa tcgtacctgc tggataagga gctcggattt 1060741 ggcacgaagt atattcatcc gcaattacgc atcagctatc cgacacttcc gctcattgcg 1060801 atgaagaaaa aaatgcgcag ggagctgctg tcagaggaat tgcgtgtgct ctatgttgca 1060861 ttaacgagag cgaaggaaaa gctgtttctg attggctcat gtaaggatca tcagaaacag 1060921 cttgcaaaat ggcaggcatc cgcgtcccaa actgattggc ttctgccgga atttgaccgc 1060981 tatcaggcga gaacgtatct agatttcatt gggccggctc ttgccaggca cagagacttg 1061041 ggggatttgg ctggtgtgcc agcacacgct gacatctcag gtcacccggc tcgttttgcc 1061101 gttcaaatga tccattccta tgatttgctt gatgatgatc tggaagaaag aatggaagaa 1061161 aaaagcgagc gcctagaagc gatccgccga ggtgaaccag ttcccggctc gtttgcgttt 1061221 gatgaaaaag cccgcgagca gctgagctgg acctacccgc atcaagaagt gacgcaaatt 1061281 cggacaaagc aatcagtttc tgagatcaag agaaaaagag agtacgagga tgaatacagc 1061341 ggcagggccc ctgtaaaacc ggctgatgga agcattctgt acagacgtcc cgcttttatg 1061401 atgaaaaaag gcctgacagc ggcagagaaa gggactgcca tgcatacggt tatgcagcat 1061461 atcccgctgt cacatgtgcc gtcgatagaa gaagctgagc agacggttca caggctttat 1061521 gaaaaagagc ttctcactga agaacaaaaa gacgctattg atatagaaga aatcgtgcaa 1061581 tttttccata cagaaatcgg cggacagctg atcggtgcta agtggaagga ccgggaaata 1061641 ccattcagct tagcgcttcc ggccaaggag atctatcctg atgcacacga ggcagatgag 1061701 ccgcttttag tgcagggtat tattgactgt ctctatgaaa ctgaggacgg attatatcta 1061761 ttggattata agtcggaccg gattgagggc aaattccagc atggatttga aggagcggcc 1061821 ccgatcttga agaaacgata tgaaacgcaa attcagctgt acacgaaggc agtggagcaa 1061881 attgcaaaaa caaaggtaaa gggatgtgcg ctttatttct ttgacggagg gcacattctg 1061941 acattatagc gagatccata agctccggaa tttcaggcgg agcgggtctc gttttctata 1062001 taaaagagag gtgaaagcat ttgcggattt tacatacggc tgactggcat cttggaaaaa 1062061 cgcttgaagg aagaagcagg ctgagtgaac aggccgatgt gctggatgaa ctgaatacga 1062121 ttgtaaagga tgagcagatc gatgccattg taatggcggg ggatgcattt gacaccgtaa 1062181 acccgccagc tttagccgag cagctgtttt atgaaagcct gtctgcgctt agcgacagag 1062241 gaaagcgccc gatcgtcgtc attgccggaa atcacgataa tcctgaccgt ttgtccgccg 1062301 cttcaccgct gacacatgaa aacggcattc atttaatcgg ttatccgaca acagagccga 1062361 ttcatattga agtgccttca gcaggagagc ttttggcggt tggagcgctg gcgtacccat 1062421 ctgaagcgcg gttaaatgaa gtgctatccg atacgtttga tgaaaagctg ctccgtgatc 1062481 actatgatgt gaaaatcagg caggcgtttg agcatatgac aagccggttc cggaccgatg 1062541 cagtgaagat tgccgccagc catatttatg tggcaggcgg aaaccaaacc gattcagagc 1062601 ggccgattga agtcggcggt gcatacacgg tggctgctga aagcctgccg gcagatgccg 1062661 cttacgttgc gctcggccat ttgcatcgcc cgcaaacgat caagcgggcg cggacgcttg 1062721 cgcgttattc aggatctccg ctcgcctaca gcttttctga agcgggctac gctaaatcag 1062781 tgacgattgt ggacgcaaag cctggggaag aggccacttg gcaagaggtg ttattatcaa 1062841 gcggcaagcc acttgtgaag tggaaagcgg caaatggatt aagtgaggtg tacagctggc 1062901 tggatgaagg cagagatcag aatgcttgga ttgacttgga aatccgtgtc gcggaccagc 1062961 tgtcacttga agagattcac aggctgcgga aggcgcaccc gggctttatc catatcaggc 1063021 cggtttttga agaacagaac aaagaccggg aacggatcga ggttaaacat gtctcaatcg 1063081 aggaccgctt taagaaattt tatgaaaaac aaactggcgg tgcggtgccg gatgaagaaa 1063141 tggtgaagct gtttttagag cttgcatcag gcgttgaaga ggaggatgcg aaatgaagcc 1063201 gatcgcctta agcattaagg ggctccacag ctttagagag gagcagacga tagattttga 1063261 aggcctttcc ggtgccggtg ttttcggcat tttcggcccg acaggaagcg gtaaatcctc 1063321 tatactcgac gcaatgacgc ttgctttata cggaaaggtg gaacgggcgg cgaataatac 1063381 gcacggaatc ttaaatcacg ccgaagatac gctgtctgtg tcctttacct ttgcgcttca 1063441 gacgaatcac caaatctcat acaaagtcga gcgtgtgttt aagagaacgg atgaaatgaa 1063501 ggtaaaaacg gcactttgcc gcttcatcga aatcaaggac gagcatacgg tgctggctga 1063561 taaagccagc gaagtgaata aaagagtgga ggagctctta gggctgacga tcgacgattt 1063621 tacgagagcg gtggtgctgc cccaagggaa atttgctgaa tttctgtctt taaaaggggc 1063681 agagcgcagg catatgcttc agcgtttatt taatttggag caatatggag acaggcttgt 1063741 gaaaaagctg agacggcagg cgcaggaagc caatgcgaga aaaaatgaaa tgcttgctga 1063801 acagtccggt ctcggtgagg cgagctcaga ggcagtggag caggctgaaa aggttctcga 1063861 acaagctgaa gcccggctgg aagcgatgag gaagaaccgt gatcaggcga aggagcggtt 1063921 tacagagcat caggagatat ggaatgtcca aaaggaaaaa tccacttatg aagaagagga 1063981 aaaacgtctc gcagaagaac agccgcatat agacagcatg caaaaacgcc tgctggaagc 1064041 agaaacagca gcagccctta agccctatgc ggaccggtac gcagaagcga tccagcatga 1064101 ggagcaagct gaaaaggaac aaacgctagc ccaaaaggat ttagcagacc ggacagcttt 1064161 ctttcagcaa aaacatgaag agtatgaagc gtggcgccag cataaaagcg agaaagagcc 1064221 tgagctttta gccaaacagg aacagctttc acgcttgcag gaaatcgaaa tcaaactgag 1064281 tgaggccaag caagaggaag agcgcaaaaa ggctgacctc cggcagaaag aagaggctct 1064341 tcaatctgtc atgaatgaat tagagaccgt aacagaccgc ctgacacgag ggcaaaacag 1064401 acagacagaa ttgaagcagc agctcaaatc cctgcaggtg acatccgatg agcgaaaaag 1064461 ctgccagcag gccgcagaga tggcattgcg catcagacaa accgaggaac aaatcaaaaa 1064521 agagaaaaaa cgaagtgaag aattgaacct cgtgctgcag aagatgaatg aagagaagaa 1064581 tacactcgtt caaaagacgg aagcggaaga aaacaacatc attcaggcat atgaggcagt 1064641 tcaaactgtg taccatttgg tgtgcgaaac ggaacgctca ttaacacgta tgacggaaga 1064701 ggctagaaag agtcaacaca cgcttcactt acagcgtgaa aaagcaaggg tggcactgct 1064761 gacaaaagag ttagcccaaa agctgactgc cggaaagcct tgcccggtat gcggttcaac 1064821 cgatcatgat ccatctgcct cggtacatga aacgtatgaa gccgacagcc atcttgaaga 1064881 ggacatcaaa cggacagatg tgttattgac ggaagctgca gctctcagcc aggagattct 1064941 ttcagccaaa attatgcttg aagaacagtc cgcgcgcttt attgaacagt gtccgttttt 1065001 gcagacaatt caagcacaga accttgaagc ggcagcttcc ttcgaacatc agccggtgta 1065061 tgaagcattt gaaactgcca aatttgaatg gaaacgaatc aagcaggaca ttctttctgt 1065121 taagacacga atggcacaaa tgattggcgc ctatcaggag tctttaaaaa aggccgagca 1065181 gcttaatgaa aaaatcggtt ttgaaaaaag agaagccgac cgtattgaaa gcatcatcag 1065241 tgagcttcaa tcctcaatgg acagcagtct gaacatgttt aaagaagcat ttcagaatca 1065301 atctgtggac gaagcagaaa aatggcagca agccattgaa gaaaaggacc gggctgcaga 1065361 agaatgtgaa aaacgaattg agaagagtat cgcgtttctt gctgagcatg aagcacaaaa 1065421 ggaaaaactg cgggaatcgg gacaccggct tgagcgggaa aagctggagc ttcattatgc 1065481 ggctgaacgc atcaagagcg tgatagctga ttatgagcac gaactcggag attatgcaaa 1065541 aggagattcg attcaaatca aactccgctc tgtccagcag gatctaaagc tgttaaagga 1065601 aaaagaacaa tctttatatg aagaactgca aagcgcccaa atgaagctca accaagcgaa 1065661 aagccgcgct tctgcaagcg agctcactct tcaagaggcg aagggcagat tggaaaaagc 1065721 aaaagctgct tggcttgagc atacaaaaaa cacctccatt acccggactg aggaggttga 1065781 acaaagtctc atcccagctg atgaacttga aaagatgaaa accggcatag accagtttat 1065841 ggataaactg aagcaaaatg ctgcaaactt aaaacgagta gcagagatac ttgccggcag 1065901 agcattatca gagagcgaat ggaacgaaac cgttgcagca ttacaagaag ctgaggacgc 1065961 atttggcgct gctatagagg aaaaaggcgc ggccgcaaaa gcactggctg tcattcgcga 1066021 ccatcataaa cggtttaatg aaattgaagc tgaactgaaa aaatggcaga tgcatatcga 1066081 caggctggac aagctgcaag ctgtgtttaa aggcaatacc ttcgtcgaat ttttagctga 1066141 ggagcagctt gaaagcgttg cgagggacgc ctcagcaaga ctcagtatgc tgacaagaca 1066201 gcgctatgcc atcgaagtag attctgaggg cggcttcgtg atgcgggatg acgcgaatgg 1066261 aggcgtacga cgcccggttt ccagtttgtc tggaggagag accttcctca cctcgctttc 1066321 acttgctctt gcgctgtctg cgcagattca gcttcggggg gaatacccgc tgcagttctt 1066381 tttcttagat gaaggcttcg gcacactgga tcaagatctg cttgatacgg ttgtaacggc 1066441 cttggaaaaa cttcagtcag acaacctggc tgtcggtgtc atcagccatg tgcaggaact 1066501 gcgtgcacgg cttccgaaaa agctgatcgt ccatccggct gaaccgagcg gccgcggtac 1066561 gcgggtatca cttgagttga tgtaagggag gagcggatat ggcaaagcag attgccggaa 1066621 tatgtgagct gtgcggccgg agcgatgtcc agctgacaga gcatcatctt acaccgaaag 1066681 aggaaggcgg aacgtttttg ccgacagcga tgctctgtat tccttgtcat aaacagattc 1066741 atgccttata taccaatcaa gagctcgctg tacgtttaaa tggaatggct gaactcagaa 1066801 gcgatccaga gcttgcccgg tttgtcaaat ggatcagaaa acagccgcct gagaagctga 1066861 tcaaaactaa gaaatcaaat gaacgaaaaa agaaaaaatg actaaaaagc agccctctct 1066921 ttgcagagcg gctgctttta tccgtttcca accatatccg gaagcaaaag ttgttgttga 1066981 aaagtaacca aaaagcggtg ctcgatgcac cgctttttta tttgcgcccc cgttggactg 1067041 ctgtgtacat aatggatcgc tttccgtttg aagccgtcca ttcaaaacgg tctcctgtcc 1067101 cttcgctgct gtagttgtag tgatgctgca tcgcgcattg tgcggtgtca tttgaaaagt 1067161 gataaaagga cacaccctgc cccgccgaag tattcgaaaa gactccttta ttataagaaa 1067221 agacgcaatc gaataccgat aagccgaagc tgtgcaagtg ctgcagaaat gcgagaaagg 1067281 tttcgtcgtc aagcgaatcc aaaagcgcca tgagcggccg cttgactgat ttctcatagc 1067341 ggatgcgttc tccgccggaa agggagatgt tttctgcacc gcatgccaaa accaacttgt 1067401 cctgaaagcc ggcttgctcc cactttcctt tatgatggat ccagattggg ctgtgttgga 1067461 gactgtccgc cagcagtata tcgccttcac cgttttcgat taagcagatg ccgtcttcaa 1067521 tgaggatggt gccgtattcc cactttcgtt cctctgtata taacaattgt ttccgtttca 1067581 tccatgctgt ctcctttttc ttcattcctc tcttttcttt ccaattcaag cctgtcccat 1067641 acaactcttt tatggacaaa tcaactatct gcctatagat gcataaactt actaaggtgc 1067701 tgaaagaaac gaaattgtta cgaaagaaac gggattggag ctgatgtcac atgtgtggaa 1067761 ttacgggttg ggtcgatttt aaaaagcagc tcgtccagga aaaacaaacg atggacagaa 1067821 tgacagacac tctttccaaa cgagggcctg atgattcaaa cgtttggggg gagcaccatg 1067881 ttttattcgg acataaaaga cttgcggttg ttgatattga aggcggacgc cagccgatgg 1067941 cgtgtaccta taaaggcgat acgtacacca ttatttacaa tggcgagctt tataacacgg 1068001 aagatttgcg caaagaattg cgggcgcggg gccatcaatt cgagcgtacg tcagataccg 1068061 aggtgcttct gcacagctac atcgagtggc aggaagactg tgtcgaccat ctcaatggca 1068121 tattcgcttt cgctgtgtgg gatgaaaagc gtaatctgtt gtttgccgcg agagaccgtc 1068181 tcggtgtaaa gccgtttttt tacacgaagg aaggctcttc atttctcttc gggtcggaaa 1068241 tcaaagcaat cctcgcgcac cctgatataa aagcgcgagt ggacagaacg ggactttctg 1068301 aaattttcgg tcttggaccg tccagaaccc cgggcactgg catatttaaa ggcataaaag 1068361 aaatccgccc ggctcacgcg ctgacatttt ccaaagacgg acttaatatt tggcgttatt 1068421 ggaatgttga aagcgaaaaa catacggaca gttttgatga cacggttgcc aatgtcagat 1068481 cgttatttca ggacgcggtg acgcggcagc ttgtgtcgga tgtgcctgtt tgcacattcc 1068541 tatcaggcgg tctggactca agcgcgatta cagcgattgc ggcgggccat tttgaaaagg 1068601 aaggaaaagc accgcttcat acttattcga ttgattacga agagaacgat aaatattttc 1068661 aagcaagcgc ttttcagccg aatgatgacg gaccatggat tgaaaaaatg acagaggctt 1068721 tcggcacaac gcaccacaaa tgcgtcatca gccaaaaaga cctcgttgat catttggagg 1068781 aagctgtact ggtcaaagac ttgccgggaa tggcagatgt cgactcatcc ctgctgtggt 1068841 tttgccggga aatcaaaaag gactttgtcg tcagcctatc gggagaatgc gcggatgaga 1068901 ttttcggcgg gtacccgtgg ttccatacgg cagatgttga gtctggcttt ccatggatga 1068961 gatcaacgga ggagcggatc aagctgcttt ctgactcatg gcagaaaaaa ttgaatctga 1069021 aagaatacgt aaatgccaaa tatgaagaaa ccttggcaga aacgccatta ttagacggag 1069081 aaacgggtgt ggataaagca agaagacagc tgttctattt aaatatgctt tggtttatga 1069141 cgaacctttt ggatcggaag gatcgcatga gcatgggggc gagcctggaa gtgcgggtgc 1069201 cgttcgccga tcaccggctt gtggaatatg tttggaatat tccgtgggaa atgaaaatgc 1069261 atgataatcg ggaaaaaggc attttgcgca aagcgcttga gggcattttg cctgatgaca 1069321 ttttgtatcg caaaaaaagc ccatatccga aaacacatca tccggaatat acaaaaggcg 1069381 tcagcgagtg gctgaaaacg atcagaagcc aaaaggactc cgtgctccat accttactgg 1069441 acagaaaaca attagatcag cttttagaaa cggaaggctc ctccttcaag gtcccgtggt 1069501 tcgggcagct catgaagggg cctcagctga tcgcccatct tgctcaaatt catacatggt 1069561 ttgaagcgta tcgcattgat attgacgaga ggtaggttca atacaaatgt gattaaaagc 1069621 cagagatgta tagatttaaa taagaaggat agatgagcag ggaaatatat gctctatcta 1069681 tccttttttg tacaacagca ctatcgaatt gcccccgcat tccttcaata agaatgaata 1069741 ggttttaatg ttctgccgat aaaactagct gataccgggc ttaactttaa ttccctagcc 1069801 catacagaaa gttgaccaat atggtgaatt tcgtgagcga tgatatggtg taatatttca 1069861 tctcgcgtat ataaaacacc tgtctcccaa ggaacgctta caagttcatc ttttatttga 1069921 tctgaatgtg tttgtaaaac atcaattatt tcagttcgga atgtatttga gagagatttc 1069981 actttattga gtgtttgata atcagcgaac tgaacagcga tatcttcttt tccttggata 1070041 gcacgaatcc aactatattc cacatcaata atatgaaaaa gggtatataa aatattctct 1070101 actccgccaa gacgattttt aagtaattct tcagtggtta gttgatgaca ccaagtaaac 1070161 cattgatctc taacctgcca gttatattca aaaaatttca tcactaaact cactccaata 1070221 ctatcatgta tcataacaat tagccctttt ttccgtgatt cctctattaa tgaagtgatg 1070281 attgagaaat gtttacattc tacctgttgt atggcattaa aaataataat gcatatctcg 1070341 tcgatgatgc tgtgcgtctt gttactttta caaagtaaga atcggcattt tcttcatata 1070401 caattaggaa aaaacatact agacttgaag aagcagtgat acataggagt gagaaaatga 1070461 aagagataaa agaagcttac cagcaatgcg gacagattgt tggcgaatac gcgccagcct 1070521 gtttcaaagc attatcatat ctcccgctaa agcaaagaca agcctcttgg gcagtattgt 1070581 cgttttgcca cacggcggcc agtgcagacg aaaaggtatt gcccgcattt gaagctaaag 1070641 ctgatcatgt ttaccaaagg acaaataacg gtaaacaaca tctatggaag gcttttgatc 1070701 atgcgtatcg gacctttaca ttggaaagcg aaccttttcg ggagtttatt gccgcacaaa 1070761 aagaagacgc caagccgtat gatgaccttg atgaactgct catgtacgca tatcggacgg 1070821 gcggtgctgc cggattgatg ctgctgccga tactgacacg ccgaaaacaa gatcagctca 1070881 aacaagcagc cgtctctctc ggcttggcca tacagctggt tcgcttctta agtgatcttg 1070941 gcacagatca gcaaaaaaac cgcattcccc gtcaggtaat gcagcaattc ggctatacag 1071001 aggctgatct ccaaaaaggc accgtaaata aagcgttcac aatgacgtgg gagtatatcg 1071061 cttttgaagc agaagcctac cttgaagagt gtcaggatgc cttgccgcta tttccgcagt 1071121 attctcaaaa aacggtgaaa gccgctcttc atttgcaccg ggctgtttta gaaaaaatcc 1071181 gggcgaagca gcacgatgta tttcaatatc acttcgctct cacagagacc gaagtgaagc 1071241 agattctgtc tgatatctaa aaaacacccg gccttgattg agccgggtgt tacgccatac 1071301 ctttttgaat ccagatacgt gagcgccatc ttctgtacat taagattccc cggacccatt 1071361 catccgcgat aaaagaaatc caaatgccgg caagaccgaa accgaggtgg atgccgaaaa 1071421 gataagcaag cgggaggcca atgccccaca ttgaaatcat tgccatgtaa accgggaatt 1071481 tcgcatcccc cgcggcccgc agagagttaa tgataatgac attaaacgag cggcctggtt 1071541 caaggataat ggtcatggca atcaataggc ttgcagttgc tataatgtca gggctttgtg 1071601 tgaagagtcc gatcaggtct tttgaaaaga tcgtcatcaa aacagaggta gccgcagcaa 1071661 ttccgagtgc ccaatataag ctcttcatgc agcgctcata agcggcatca aattgtttgc 1071721 cgccgatata acggccgatt aagatttgtg taccctggct gatcgcagtg ccgaacagca 1071781 aaataaacat cgtaatattt tgcgtataca cttttgttgt caacgcctgc gcgcccatga 1071841 tggcgataaa atacgtgact atcatttgcg acaggttgta tgaaagctgc tctcccgcag 1071901 aaggaatgcc gattttcagc agcttgcgca aatgctcttt atgcatatga aagacttttt 1071961 tcagcgacat cttcagctgg atgcgtttgt tgacaatcac aatcatcgcg attaatccga 1072021 tgacgcgggc gatagatgtg gacatggcca caccggcaac accgagaaca ggaaagccga 1072081 acaaaccgaa aatcacaaca aagtttccgg caatgtttaa aatgttcatg ccgatagtga 1072141 caaacattgt atcttttgtg tagccgtagc tttttaagat cgcgctgaat gtcatgatta 1072201 aagcctgaat aaaggacaga cctccgacaa cttgtaaaaa gactttcgca tcaggcatca 1072261 gtgcgtctga taatcccatc atatgaagca gagggacagc cgcgaaaaag acgacggcgc 1072321 tgatggccag gctgatgaag aagttggcgc cgattgacac ataagcgact tccatggctt 1072381 ctttcttttg ccgtgagcct agaaattgtg aaatgataac ggtcgttcct gttgcgataa 1072441 agctgaacat cacgataatt aaatttaaaa tctggttgct gacgccgact gctgccacgc 1072501 tgttatccga gtattggctg agcatcagtg tatcggcatt acccataaac atatataatg 1072561 agacctcaat aaagatcggc caagtaagcg aaaataatga gaacgttttg tcagcgggtt 1072621 ttttcaaagc agttgatttg aagacagctt gtttcatcgt gtctaacccc tttcgtaaat 1072681 aaaatcaacg ttttaaagtg tacctccatt tccttataat aaaaagggat agaaacgata 1072741 cttcttgtaa aaatccgact taaaaaggag gatgattcaa atgcctcgca tcctgtttac 1072801 agtcccgcct tttccggtat ttatcgcagc tggggaaggg gtttttaaaa aaggagaaac 1072861 ccatgtgaaa cgtgtattct ccgtgtttga tctgatatat gtcaaacagg gaacgttata 1072921 tataacggaa aatgaaacat cgttttctgt tgaaggcggc gagtacatct tgctttctcc 1072981 cggtcttgaa cactacggga cgaagggcag tgatgaagca acctcctact attggcttca 1073041 cttcgatgaa catcgatatg aatttacggc aaagggaggc agcaactggt ctgagcttca 1073101 gcaggaaaaa gggagcttcg aagagctggc ccgctacgga ttggccttgc cgagaaaagg 1073161 caaggtgcag cgcccgcagt ttatggcgca gcagtttgaa aagctgatcg attactccgc 1073221 ggaaaactct gatttgccgc tcagaaagca aattttattt gaggagctga tgctgcatct 1073281 tcaaaaagaa gcgttccaaa taccgtctgc gaaagagcgg gtagcctggg aggcggcccg 1073341 gtatttacag gagcactata aggaaaagac gacaatcaag gatctgtcgc tcgcccttca 1073401 ctatcatcag gattatgtga gccgctgcat gcagcaggtg ctcggcgtaa ctccggcaca 1073461 atacacgaac cgggtgagaa tgacggaagc gaagcgtctt ttatcctcta caaatgataa 1073521 aatgggcgtt attgcggaaa cggtcggaat ggaagatccg acatactttt caaaactctt 1073581 taagcagata gaaggcattt caccaattga ataccggaaa attgtcagcc ggaaagttca 1073641 ataaccagac gagggatgaa catgaaaaca acaatttacg atgtggcaaa ggcggcgggt 1073701 gtttcgatca caactgtgtc ccgtgtgata aacaatacgg ggagaatcag cgataaaaca 1073761 cggcagaagg tcatgaatgt catgaatgaa atggcataca cgcccaatgt ccacgccgcg 1073821 gcgttaacgg gaaaacgaac gaatatgatc gctctcgtgg cgcctgatat ttcaaatccg 1073881 ttttacggcg aactggccaa aagcattgag gaaagagcgg atgagctcgg ttttcaaatg 1073941 ttgatttgca gcaccgatta cgatccgaaa aaagaaacaa agtatttttc tgtgctgaaa 1074001 cagaaaaagg tggatggcat tatttttgca acagggattg aaagccatga cagtatgtct 1074061 gctttggagg aaatcgccag tgaacaaatt ccgattgcca tgatttctca ggataagccg 1074121 cttcttccga tggatattgt tgtgatagac gacgttcgtg gcggatatga ggctgccaag 1074181 catcttctgt cactcggcca cacgaacatc gcctgcatta tcggagacgg gtcaacgaca 1074241 ggcgaaaaaa atagaatcaa aggcttccgt caggcgatgg aggaagcggg cgtgcccatt 1074301 gatgaatcac ttatcatcca gacgcggttt tccttggaaa gcggcaagga agaagcggga 1074361 aaattgctcg acagaaatgc tccgactgct atttttgcct tcaacgacgt attggcttgt 1074421 gccgccatac aagctgcgag aataagaggc ataaaagtgc cggatgatct ttctatcatt 1074481 ggttttgata atacgatact cgcagaaatg gcggctccgc ccctgacaac cgtagcccag 1074541 ccgataaaag agatggggcg gagcgtcatc gaactgctgg cagaagcaat agagggaaaa 1074601 cgaaaggcga aacaaaaaat agtgctcccg cctgagcttg tagtcagaca ttctacatca 1074661 ccgctcaaca catgagcccg ctaatgagcg ggttttttca ttatgacagt tgaagccaaa 1074721 aaaacatatt gcgtgtaaac caaaggcggt gtaaaatata accatctttt gagaaagcgc 1074781 ttgcgcaaaa tggcagagcg gatagaaccg ctgttttttt agctgttaag agaaaacgct 1074841 ttctcaaagc gagcccgaaa tgagataaag gagaggatgg gacgtggaac atcaagtaag 1074901 atgtgcagta ttgggattag gaaggctcgg ttattatcat gcgaaaaatc tcgtcaccag 1074961 tgtgccgggg gcaaagctgg tttgtgtcgg tgatccgtta aaagggagag cggagcaggt 1075021 tgccagagaa ctcggtatcg aaaaatggtc agaggacccg tatgaagtgt tagaagatcc 1075081 cggcattgat gctgtcatta tcgtaacgcc gacaagcaca catggtgata tgatcatcaa 1075141 agcagccgag aacggcaaac agatctttgt tgaaaaaccg ctgacattaa gccttgagga 1075201 atcaaaagca gcttctgaaa aagttaagga gacaggtgtc atctgccaag tcggctttat 1075261 gagacggttc gatcccgcat acgcagatgc caaacggcgg atcgacgctg gagaaatcgg 1075321 caaacctatc tattataaag gctttacgcg cgaccaaggc gcgcctcccg cagaatttat 1075381 caaacacagc ggtggaattt ttatcgactg ttccatccat gactatgata ttgcccgtta 1075441 tttgctaggg gcggaaatca cttctgtttc aggacacggc aggattctga acaatccgtt 1075501 tatggagcag tatggcgatg tggatcaggc gctgacgtat attgaatttg actcgggcgc 1075561 agcgggggac gtcgaggcaa gcagaacctc tccatacgga catgacatcc gggcggaggt 1075621 gatcgggaca gagggcagta ttttcatagg gacattgaga catcaacatg tgaccatcct 1075681 atcggctaaa gggagcagtt ttgatatcat tccagacttt caaactcgtt ttcatgaagc 1075741 ctactgcttg gagcttcagc atttcgccga gtgtgtccgg aatggaaaaa caccgattgt 1075801 gactgatatt gatgcgacga tcaatttaga agtgggtatc gccgcaacca attcctttcg 1075861 aaacggcatg ccggtacagc tagatgtgaa gcgcgcttat acaggtatgt aaaagctaag 1075921 tatgttgcat ttgaggcttt ccgcaaaaaa agcaagggca ttttagccct tgctttctct 1075981 tttctcatat aaatagtaca tataatcagt aggtacgcct gaatggtcca gctgtctcag 1076041 catggcggtt acgttccctc tgtggtaagt gccgtgattg acgacatgca ggatggtgtc 1076101 tgcataggtt gattccagtg tacctagttt cggatgctgc attgtgaagg tctgttctaa 1076161 gtccgtctgg cggctgaaga aatcatgata ctgtgactcc agctcggcag cgtgctgttt 1076221 aatcgctgcc atattacctt gcgcggactg taatttgcct gcgctgtcta taatctcttg 1076281 gtaggccact cccgaaagaa cattcagcca aatgtagtca gccctgcaca tatgaagcag 1076341 cacgtcgctg acagaaggaa atacgctctt tacttcttga taggcagttt cctccggcag 1076401 gttttcgata tgggtaaata ttttcttgtt tgcccaagaa tgatagtcat aaaactgttt 1076461 tgcatcagtc atcagcatgc ccccttttct aagaaattcg tttttttcat ctgtttctcc 1076521 ttcaattgca aaagagtgac accccaaaat atcctgccgc tgcccacatt accgctgcag 1076581 agcatttgtt tacgatcagc ataagcctgc cgctcgtatc tatcgtctga aacaaccggc 1076641 ccgctattgc aaggctgatg aaccaaatcc aagacacagc gatgcaggcg gccataaaga 1076701 gccatttctc aagccccgaa tattgaagag agctcgtgcc gatgacgccg atcgtgtcca 1076761 gaatggcatg cgggtttaaa agagaaacag cggccgcaaa cgcagcttgc ttttttggtg 1076821 tgaacgtatg tttctcattt tggcttgtgt tcggacggat gttccaagtc acccagccca 1076881 tataaagcaa aaataaaaat ccgccggcca tcatgactgt ctcaaacaca ggcagctcct 1076941 gcacaatgac agacacgccc gcaacggcta atacaattaa caaggtatcg cagactgaag 1077001 cactgatgac agctgggaga gcccgccaaa tatgcttttg caacgcgcct tgctgaaaaa 1077061 taaacacatt ctgcactccc agcggcaaaa ttaagccaaa cgcgagcaca attccgtgaa 1077121 tgattgcatt catgctgaaa aagctccttt cacatttttt ttcaatcata agagagattg 1077181 tcactaaagt ctccagccat ttggttgggt taggaaccag ccaaatgtat aatgtgtaaa 1077241 aaaggggggc atgaccttgt cgcaatggca gccaagccga aagtcggatg ttccgctgca 1077301 tcggcagatc gaacaatata tgaaagacaa gattcttcac ggagagtggg ctgtagggac 1077361 gaaaatcccc tcacagagaa cgctggccga catgtttcaa gtcaaccgca gcacagtcac 1077421 agcagccata gatgaactca cgtctcaagg cttgttagag ggaagaaaag gcggcggtac 1077481 gaaggttgta aacagtactt ggagcgtgct gacggctgag cctccgcttg attggagcga 1077541 ttacgtccgt tcgggcattc atcgcgccaa ttcttccatc attcaagcta ttaatcagaa 1077601 cgaaccaaga gcggatatca tcagattagg aactggagaa ctttcaccgg atcttgtgcc 1077661 tgctgacaca attggacgga tgtttcagca aatcaatccg ggcgtcctgt ctttaggata 1077721 tgagcagccg aaaggaaacc gtcagctgcg ggaggcagtg gccgaccatt taaaaggaaa 1077781 gaagatccat gtgtcaccgt ctgcaatttt aattgtgtcc ggtgcacttc aggcacttca 1077841 gctcatctca attggacttt taaaacgaga ttctgtcatt ttgacggaga agccgtccta 1077901 ccttcaatcc ttgcatgtat ttcaatcagc tgggatgcgg cttcgcggct tgccgatgga 1077961 tgatgaaggg gtcaaagcgg ggcttgtttc ttctaatcga aaacaatatg gaggacagct 1078021 gctttacacg attccgtcgt ttcataatcc gacaggcaca gtcatgtcag agcagcgaag 1078081 gaaagagatc atcagcctgt caaaaaaaga gcagatgccc atcattgagg atgatgcgta 1078141 cggtgattta tggtttgaag aaaaaccgcc gcagccgttg aaagcaatgg atcatgaggg 1078201 caatattctg tatctgggcg cgttttcaaa aacggttagc cccggtctgc gaatcggctg 1078261 gcttgccggt ccggagccgg ttattgaaag gctggcggac attaaaatgc agacagacta 1078321 cggatcaagc ggcctgtccc agtgggcggc tgccgagtgg ctgtcacagg gatattatga 1078381 agagcatctg acttgggtac gcaggaagct taaagaaagg agagacgccg ccgttcattt 1078441 tctcgagcgg tatgccgggg acattgccac gtggcggatt cccgcaggcg gcttttatat 1078501 ttgggtgaca tttcacaaaa acctgcctgt cagccgtttc ttttatgaat tgctgaaacg 1078561 gcaggtgctt gtgaatcccg gctatattta tgacggtgaa gaccgaaaca gcatcaggct 1078621 gtcatattcc tatgcatctc ttggagattt ggaaactggc attaaagcgg cagctgaaac 1078681 agcacgccgc ctgatgatgt cctaggcttt ggttatacga tgacagctcc cagtgccctg 1078741 gcgaaggcaa tcgcgtgctc aggtgcgatt ttgcagcctt tcaatttgtc gagggagaca 1078801 tgaagctgtt caaaacggca cgtgctgatg tccatgtttt gaagggacgt gccggtaaag 1078861 ctggcgcctt ccaattcgca tccgtcaaag tgtgtctgct ggagcaccgt atcgctgcat 1078921 tcactttgca taagagcaca gtgatcaaat cgaacttgtt tcatatttga gtacgaaaat 1078981 gagctgaaat gtccgtggca ttcctcgaat gaaacattcc gcagcgttgc ttccgccaca 1079041 ttcattccaa ccatttttga ctgcttaact gaagttctgt gaatgacagc cccgctgaaa 1079101 tcggcgtttg ataaatcgca tttttcaaag atcacatcgg tcagttcaat atgccgaaaa 1079161 gacacatcga taaagacgac atttctgaat accgtttttt caacacatag tctttcgata 1079221 tcttcgccgc agatggtgca atcttcaaac aaatgcatgc tgattacatc atcctgtgtc 1079281 acggcatcat gaaaatctgc ggtttgcagg ttttccggta tgttcggttt ttgaattgcg 1079341 attttattca tgtgatgaca tcctttgctg cccgaaaaac agaggcttcc gggttcaatt 1079401 taatagatcg ttaaggaaat tgatacatat agtaaatcgt gaagagcctt ttcttggtac 1079461 agcagcccgc ttgttttgta agcataaatg gaaagcttcc tatacgtcaa ggcgtttaca 1079521 ggccgaaaaa gccaaaggga acaggaggaa tgcggaatgg ggcattacat caaaaccgag 1079581 gagcatgtga cactgtttgt agaggatatc ggacatggaa ggccgatcat ctttttgcac 1079641 gggtggccgt tgaatcataa gatgtttgaa tatcaaatga atgagcttcc gaaaagggga 1079701 tttcgtttta tcggcgttga tttgcgggga tatgggcaat ctgaccgccc ttgggaaggc 1079761 tacgattatg acacgatggc cgatgatgtg aaagcagtca tttatacgct gcagcttgag 1079821 aatgcgattc ttgccggttt ttcaatgggc ggcgcaattg caatccgtta tatggcaagg 1079881 catgaaggag ccgatgttga taagctgatt ttactgtctg cggcggcccc cgcgtttaca 1079941 aaacgcccgg gttatccgta cgggatgagg aagcaggata ttgacgatat gattgaattg 1080001 ttcaaagctg atcggcccaa aacactggct gatttaggga aacagttttt tgagaaaaaa 1080061 gtgtctccag agcttaggca gtggtttctc aatctgatgc tggaggcttc ctcctacggg 1080121 acgatccact cgggcatcgc attaagagac gaagatctca gaaaggaact tgctgcaatc 1080181 aaggtgccga cgctgatcct gcacgggaga aaggatagaa ttgcgccgtt tgattttgcg 1080241 aaagaattga agcgcggcat caaacagtcg gaattggttc cgtttgcaaa cagcgggcac 1080301 ggagcatttt atgaggaaaa agagaagatc aacagtttga ttgcgcagtt ctccaactca 1080361 taagaaaaaa cccgacattg atcgggtttt ttatataatt cctctgtttt gcagtgcgtt 1080421 aatgatgaga tcagctccat cggaaataga ggtctggtca gactcaatga tgaaatcggg 1080481 tgaaagcggc gcttcatacg gagaatcgat cccggtgaaa tgtttgatct ctccgtttcg 1080541 cgctttttta taaagccctt ttggatcgcg ctgttcacaa acatgcagcg ggcacttcac 1080601 ataaatttcg aagaactcac ctttaggaaa gagcgctcta accatgtccc gatcctctct 1080661 gaatggagaa ataaaagccg ttaaaatcat ttgcccgctg tcgacaaaca gcttcgccac 1080721 ttctccgatc cggcggatgt tttcaatcct gtcaccagtc tgaaatccaa gatctttgtt 1080781 taagccgtgg cggatattat caccgtcaag cacgtagctc tgaatgccct tgcggtaaag 1080841 cttttcatcg acagcattgg ccagcaccga ttttccggag ccggacaaac ctgtaaacca 1080901 aaggacgcag cttttgtgtc cgtttaagga ctgtctgtca gactttgaga tggcagcggg 1080961 atgccaaatg atgttcggat tgtgtgtcat tgcaattccc cgctgttttg cttgatggca 1081021 acaggctgtt ggtgaagtcc cttgatcagc acggctgcga cctcaggccg gctgaattct 1081081 ttaggcggct ttttgccttg gcggagaagc tctctcactt ttgtgcctga taagtggatg 1081141 tggtctctcg ggctgtgcgg acatgttttg gaggtgccca tgtttccgca ttttcggcaa 1081201 taaaagctgt gctcaaaaaa cagcggcttg atgcccagct cttcctctgt gaatgattga 1081261 aaaatatttt gggcgtcgta tgttccatag tagctgccga cacccgcgtg atcacggcct 1081321 acaataaaat gggtacagcc gtaatttttt cggacgagcg catggaaaat cgcttcccgc 1081381 ggacctgcat aacgcatggc ggcagggaaa accgataaca tgacacgatc ctttggataa 1081441 tagtgattaa gcaaagcctg gtagctctcc attctgatat cgctggggat atcgtctgac 1081501 tttgtttctc cgacaagtgg gtgaagcagc agaccgtcga ccgtttctaa cgctgttttt 1081561 tgaatgtatt catgcgctct gtgaacaggg ttcctggttt gaaagccgac aatcgtcttc 1081621 cagccgagtt tttgaaaggc cgctcttgtt tcagcgggcg ttgcataaaa ctgttcgaaa 1081681 gatttgtcag gcaggctgct gaccgtgata ggccctccga tatagtaatc cgggcgcgcc 1081741 agcaattttt ttacgcctgg gtgggcagga tcgtttgttt taaaaacaga cagtgcttct 1081801 tgtgttttat caggctggta tatatcggtg actgtgatca tgccgtaggt aacaccgtct 1081861 ttcacaagct tgacgtgatc tccggcagac agctgtcttg ctgttttttc tccgacaggc 1081921 agcgtaatcg gcaggctcca cggcaagccg tttgccagcc tcatctcttt cacaacggaa 1081981 tgataatctt tttctcccaa aaaacctgtt aacgggctgt agccgccgat cgcaataagc 1082041 tccagatcac tcagtgcaag ctgatccagc tctgcttggc acgcgcaccc ttcaaaatgg 1082101 catgcgggat cacagcggtt gattaatacc cctccgtggg gttcgtttcc attcaacgtg 1082161 ttcaacctcc atttatacgt ttccttgttt tcttttctgc acttaatgaa agtttgacat 1082221 cagcgcctta acatcatttc gattctcaca tcaagaacct gccatccgct attcttgatg 1082281 caggccgcat tctgttttct cccgtccggc ccatcttcca gccctctcat cgttcgggtc 1082341 cggggaaggc agtgtacaca tttcacagcc tatgctcgga taatgttgat cgtgcagttt 1082401 gttataaggc aaattgtgca ggcggatgta cgtccaaacg tcatcccatg tccagtggat 1082461 aagcgggcaa attttgatga gctcaaactt ctggtccagg tttacgtatt gaatatgctt 1082521 tctcgttggt gactgatccc ggcgcagtcc tgaaatccaa gctgtcatgc cggacaggtg 1082581 ctttttgagc ggttcgattt tccgcaattg gcagcagagg ttcgggttat gcttccacag 1082641 ctctccgccg tacttcgtcc cctgttctgt taagctcagc tcgggttcga gcatctggat 1082701 tgcaaatccc ggatatcgtt ctttgacggt ctcgatcagc tcatatgttt cctgaaaatg 1082761 aagcccggta tccaaaaaga tgatgtgtgc gtttttgttg atttttgata ttaagtcgag 1082821 aagcaccatt ccttctgcgc caaagctgca ggcgtacaca atcttttctc cgtacgttcg 1082881 gtaagcccat ttcaacacat cgagctcatc gatcaattga tccgttatct gtttggacag 1082941 catgtcgttc caagtgtcat atgtgatggt ttcgttcaat gttttccccc cgtttgcatc 1083001 tgcttttttt atctattgat cgagttatag gcagactatt cattttttgc ataaaggttc 1083061 aggttttagg tgccgcgccc gcctaaaatg aggtgcggaa ccattaagag cccggctgaa 1083121 tatgcttttt agcaaaatgg ttttatgccc aaggagaggt agtatgccga ttgccattta 1083181 tcaggggcat catcattcgc ttgccccggc ggacattaac atcgtcattg atgtcatcag 1083241 agcctttacg gtcgcccatt atgcgtttat cggcggggcg aaagagattt tgttggtccg 1083301 gacagctgat gaagcctttg cgctgaaaga cacctatccg gattatgttt tgacgggaga 1083361 ggaaaagggg gtcggtatca gcggatttga tttagataat tctccaaaac gtatggctgg 1083421 gcagaatatg acggataaaa gcctgatcca gaaaacaaca aacggcgtca cagcagcatt 1083481 gggggcgctg aacgcaaagc atctgttcgt aactggattt tccaatgcca aaacaacggc 1083541 acagcatgtg aaaaagctcg tcgcaaacga ttgtgtcata aacatagtgg cttcccatcc 1083601 atccggtgat gacgatatgg catgtgcgga gtatatcaaa ggcatcattg aagggacaaa 1083661 tgtggtaacg gctgcggagg cgattgaaag aataaaaggc tcttctgttg cggagaagtt 1083721 ttttgactgc cgccagccat tgtttgattc ggaagacatc gtttactgta caaaagaact 1083781 gacgggcgat ttcgtgatga aagtgaaaca agatggagaa gttccaacga tagagagggt 1083841 cataatatga atgatttttc actagaattg ccagtgagaa caaacaagcc gagagaaacc 1083901 gggcagtcca ttttaattga taacggctat cccttgcaat ttttcaaaga tgcgatagcc 1083961 ggagcgtccg actatattga ttttgtgaaa ttcggctggg gcacatcatt acttacgaaa 1084021 gatcttgaag aaaaaatcag cacactgaaa gaacatgaca ttacattttt ctttggcggc 1084081 acactgtttg aaaagtacgt aagccagaaa aaagtgaatg aatttcatcg gtactgcacc 1084141 tatttcggct gtgaatatat tgagatttca aacggtacgc tcccgatgac aaataaagag 1084201 aaagcggctt acattgccga tttttctgat gaatttcttg tgctcagtga ggtgggcagc 1084261 aaggatgcgg aattagcaag ccggcaaagc tctgaggaat ggcttgaata tatcgttgag 1084321 gatatggaag cgggcgcgga aaaagtgatt acagaagcca gagaaagcgg aacgggaggg 1084381 atctgttcca gcagcggcga tgtcaggttt caaattgttg acgacatcat ttcctcggat 1084441 attgatatca acaggctgat ttttgaagcg cctaacaaaa cgcttcagca agggtttatt 1084501 caaaaaatcg ggccgaatgt gaatcttgcc aatattccat ttcatgatgc catcgcgttg 1084561 gaaacgctgc gtttagggct aagatccgat accttttttc tgtaaaatag cggctgcggg 1084621 gctctcgtcg tgaagagagc ctctgcctat tattttttat ggcggtacat aggcgtgaga 1084681 tagggaagtg aggtcaggcg gatgttgtag atgaagtcga tgactcttgt cgatatcacc 1084741 tggcatatga gggcttgaat gacgatgccc cagtcaataa tagacgcggt gaccataaaa 1084801 atgatgcaat tcatgatgag caggatcgtt ccaggattcc cgccgcggta gatagaaatc 1084861 atcagagcaa gggctccgaa tcctccgttc gaaattttat atttgtataa aagtccgatt 1084921 ccgagtccca ataacactgc gccgcttgcc agatcaagcc acaggttaga tgtgatatca 1084981 ggaaaaactg catcaaagat caataccgag acagaggtga cggtgataga agcgagggtg 1085041 ccggtgaatg ttctcatctc cagccatttt aaagcggtaa aaagcattga tacattcaca 1085101 gcccacactg aaaatccgtg ggggatttga aacagataat gcaatagcac cgcaatacct 1085161 gctgcaccgc ctgtcggaat atcatgcgga aataaaaaca aggacatgcc gagtccttgt 1085221 agtacgccgc ctacgacaat cataaacgta agttttgctt tcatcagcag ttcagccatt 1085281 aagtcatttg ctcctttatg aaaagacttg tccgctgttt tcattttatg aggctgtcca 1085341 ttatttatgt ctcaaaataa agaaatggcc cagcttaata ggctgagcca tcccacttgt 1085401 agcgattgac gatctccata ttgatctctg tgccaatgcc ttttcctttc gggatgtgga 1085461 ccattccttt tgaaggctgc aggctgacga gatctgtaaa aggattctcc atgacgtccc 1085521 actcgatcgg ttcaatgtga tcgttcttca ttttagacca tgggggcaga caggcttgtg 1085581 caaataaagc atagagccgt gagagcgatc cgtcatatgc atgggcggat gctctgacgc 1085641 cgaaataacg cgcgagctgg aggcagtccc gaaactcatc aattccgttg acatgcatga 1085701 catcgggctg aatgatatcc aaacagcgct gtgaaaggag aggcacatat tgcgccgggc 1085761 ctttcatgtt ttctccgccg gcaacaggaa cagacaaacg gcttcgaagc atagcgtaat 1085821 cctgcggctg atcaaagggc aaaggctcct caagccagcc aatgttcgtc cattcggaga 1085881 aatagcgctc ccatttaaaa gccgcagcgg catcgtagct ttggtttgcg tccagaatca 1085941 tcgtaatgga gctgcctgct gtatgctgca gcgcattgat gtgccggaca tcctccttga 1086001 atgaagtccc gccaattttg actttgattt gctcaaaacc ttttttcaac tgggcttcaa 1086061 cattggagac tgagcggctg atccattgcg gggagtctga gtacgattga aaagacgcgt 1086121 acacaggaat ctcctctctg tatcgcccgc cccataattc gcaaaccgaa caatccgcag 1086181 ctttggctgc aatctctgtc agcgccatgc ttacagcgga ggccgcccgc tggtgccatt 1086241 tttgaatcgt gcgcactaat gacaggcggc tgccagcctg ttttcctaat agaaatggga 1086301 tgatccgctt cgtaaaaccg acatggagag cagggagcca atcaacgcat tctccccagc 1086361 cgtctatccc gctttcggtg ataatcctga tgagataaca agtccgatat cgtttaaacc 1086421 cattggcatc tccgtatggc ttttctaatc gatgaaatag cggaaaggtt tcaatccgta 1086481 caattttcac actgggtgct acctttcctc agcgggctgg agccgattgc cagccatttt 1086541 agggtcttct ttttcttttg tttcttcatt gttttgcttc acatggatga gcatcatcac 1086601 aagaatcccg acaacgagag tcaatcccgc gatgcttaaa aacatgccgg gtctggacca 1086661 ttgcatcagg cggccgaaaa tcggaggacc gatcgctacc cctaagaaac gtacagagcc 1086721 gtacagcgag gtgacaaatc cccgtctttc tttgccgaca gccccggtaa tgaaactgtt 1086781 cacacaagga aggacaagac ctgagcctat actgctcagt acaagaacac tgataaaaag 1086841 gacaagattt tcaatgaatg acagtgccgc gtaggatacg gtcatgaacg ccaatccaag 1086901 tacgatcagc tttttcatta acgattgctt ttgcccgatt ttgcttcctg ttgtatagga 1086961 cgtcacacac ataaccaaaa gcgggatcgc taaaattaag ccttttttca cgccgtcggt 1087021 gtcgtatgtt ttttcaagaa catctgagag ataaaacagg atgccgaata aagtaaacaa 1087081 acaggtcgca ccggctaaat aagcggtaaa cagccatctg ccttcatgtt taaagacact 1087141 taacagccct tttgcatatt gtccgattgg tggcggttct ttttcctttt tcttttcttt 1087201 aataaaaatc caagtcagta cgatcgaaat gatacaaaac acaggaaagg caaaaaacgc 1087261 gccataccag acaagcaggg cgatcagcga gccaatgatc ggcgatagca ctttccccat 1087321 gccgtttgaa gcttcaacaa ggccgagcac cttgctctcc tgggcgcctt taaacagatc 1087381 tcccgtcagt gccatggcaa ttgggccggt tccggctgcc ccgattccct gtaacgctcg 1087441 tcctgccatg acccaaggat aggcattgtc aaaaaaacct gccgcaaacc cggctaacaa 1087501 accgccggca ccatacaaaa ttaagcaggg aataatgatg actttccttg agaatcggtc 1087561 tgcgagataa ccgacaatcg gaatcgcaaa tgctgcaatc aaggaaaata ctgtgatcac 1087621 gagactgact tgaaattgtg ataaatgaag ttcagatttc atttttggca aaatcggaat 1087681 aagcatcgag tttcctaggg ttaatattaa agggattgaa ccgattgcca caatcgtcat 1087741 tccgttattt tgttttgatg attccatctc agagcacact ccttttcttc tgcttagaat 1087801 gtccctgatg gcttcgttta ttcagcgatc agacagcaaa aaaccgaaca gaagatacct 1087861 gttcgggaaa aaagagggtt aaccgagagc ctgtgaaatc aaagcatata agtgtccatt 1087921 ttgaataggc gcttttttct gatagaacaa aatcggaggt tcatcatctt tatgaaatcc 1087981 catttctatc aggctgtcat gcagagacgt gtgttcactc ggtatatcga ttcgcatcgg 1088041 cccttgtttg ccggccgcca gccttgtaat tatctgtgct gcaacatctg atgatggagc 1088101 gatgataggg ccgaatttca aattggccgg tgtctgtaca gaaagtccgt agccaatgag 1088161 ctgtccgtcc tgatttctgg cgatgataca ttcgcatgaa gcagaaataa gctgctgcaa 1088221 aaggtttgat cgatctccgc caaaggcagc cagatccgcc gcggttaagt cgtgaaagtc 1088281 ttgttctcta aaggatgtca gttcagcatc aagctttttt gtataaggtt gaaaactgtg 1088341 acagctgtac tttcgcactg aacctgccgt atgaaaacct gctttttcat aaagcggcaa 1088401 accttctttt gtggcgcaaa gcctgatggc ggtgttttca tccgtttggg taatacaggc 1088461 gtttaccata cgccggccaa gaccgagccg ttgatattcc ttgtcaacga taacaaggcc 1088521 gatagaagta agacggccaa acaaaaacaa gccgatgcag gaaataatat caccgctgac 1088581 attttgataa ccgaaaaagc gtccctgctg aacaagcagt ttcagctctt gttcgccata 1088641 atccggccac ccggcttgcc cgcaaagccg caataagccg gaaacgtgtt cttcatgaag 1088701 cttaatcagt tcatctacta cgtccataag atcacctgct tgttctaagt gttttgtaca 1088761 tgacaatatg attgccaatg ccgggaatgt caaatggttc gccaagttcc ttccagccaa 1088821 gcttggcata gtagcccttg acatggtgtc ttgcgttgca ccataccgcc tgaacgccgc 1088881 tctccgccag tttgtgctcc gcgtgtttga tcagcgtgct tccagctttt tgatcgcgat 1088941 atccctcgag cgttgccatg cctctcagcc gatacgcaga ggcttccgtt aataaaggct 1089001 gactttgcgg ggaaaaagaa gcgatgctga tcagcgttcc atcataaaac acgccgagat 1089061 gaaaggagcc ttctgcgtga tcctctttat atttgcattg ttcgatggat tgatggggac 1089121 gcagaatgcg atgccggatt tcatatgtat cttccacgga aatggttttg acttcgagca 1089181 taatgttcct cctcatgatt gtttttctat atcgtaacac gaatctcgtt gaaaaagact 1089241 gcccgattcg atcaggcagt cttttggaaa ttaatgcaaa aagatatttt ggcgctgctc 1089301 atctttttgc tgaatatatg atgtgagctc agcggttaag tcagatctga ggaaaggcgt 1089361 tatcaagtag atgccgttaa acagctcgca tgccgtatcc agcagggagc gtgcaattgc 1089421 aaggccttcc gccttttgct tttctttatc ttcaccggca tgggccattt tttcgcgaat 1089481 cgtatcagac agcttaatgc cgggaatttc attatggatg aattcggcat tccggctgct 1089541 tgtcagcggc atgatgccga tatagatcgg cgtcttcaga tgttttgttt cgttatggat 1089601 atcgacaagc tgctgctcgg aatagacagg ctgagaaaca aaataatctg cgccgcaatc 1089661 tatttttttc tcaagccgtt ttaccgcttt atccagatgg cggacgttag gattaaatgc 1089721 ggcggcaact gagaaattcg ttttcttgcc gagcggtttt ccagacagag acagaccttc 1089781 attgaattgt ttgatcagcc tgattaaatc aaaagatgtt aaatcatata cagacgtcgc 1089841 cccaggaaaa tccccgattt tagaagggtc acctgtaata gcaagcacgt cattcagccc 1089901 taacgtatca aggcccatta aatgtgactg taagccgata atgttacggt cacggcacgt 1089961 aatatggaca agggaacgca tatcgagctg ctgcttgaca agggcgccgc aggcaacatt 1090021 gctgatccgc ggggtcgcca aagaattgtc ggcgagtgtc agggcatcga ttcccgcttc 1090081 ttttaattca gcagcagcgg acagaaattt gtcaaagctt agttttttcg gcgggtccag 1090141 ctctacgata atagagcgtt ttttcgctgc gatctcatcc aggccgggct cggttcgctc 1090201 gtgatgaaca gaaatgaatt ctttcgcccg ggttttgact tctttttccg taatcggagc 1090261 cagcccgcca accgcttccg ccatcgccct gatgtgattc ggcgttgtgc cgcagcagcc 1090321 gccgataatc cgcgcacctt gcttacggaa ttctgacgcg ctgttttgaa aatacgtgtc 1090381 gtctgtttca tagacgagcc gtccctcttc aagcgaagga agactgctgt tcggataaac 1090441 ggataagaat acgtcatcaa aaatcggcac ttcgcttagc gcttcaatca tgtgataagg 1090501 gccgaggcgg cagttaatgc cgacaatatc agctccgaga tccgcaatcg agcgcaatgc 1090561 gtcagaaagc ggcgttccgt cctgcaatac gccttgctcg tgcatggaga cattgagcat 1090621 aatcggaaga tcagtctctt tgcgcgcgat tttcagcact tcacgggctt cttccaaatc 1090681 ataatatgtt tctaacagca agccatccgg ctcttcatgc agcagcagat acagctgctc 1090741 gcggaagctg cgcttaattt cgtcaagact gtatgcgttt ttattaaatg tgcgtatgcc 1090801 gcccatcgtt ccaagcacgt atgcatcgcc tgctgaagcc cgcgcgatct ttacggcctc 1090861 ctgattcatt tttttgatgt catcctcaag cccgtgtctg gataatttaa tatagttggc 1090921 tccgtacgta ttcgtttgaa taatgttggc tcccgcttca acgtacgctt tatgtatgcg 1090981 ctgaatttcc tccggctttg aaatattgag ctcctcaaaa cacctgtcaa tgccatagga 1091041 gtagaggagc gtccccatgg cgccgtcacc gattaacacc tgtctttgca aatcttctaa 1091101 aagtcccatt gtctgcctcc tttattcaca tcagcaagga aaaaagagaa ataaaaaaag 1091161 tcctcttaag aagaagactt tgtcagtgat tttgtctctt cttatcttcc aagctgttcg 1091221 agcttgctgg atttagcacc ttggtcatgg ctgatcgcca ttacaccggt tgctgaagct 1091281 tcgtcgggcc agtccctctg cttctcttga taagaacgga tatgaaattt tcgtgtcagg 1091341 aagtgccaaa agatatctgg cgtttttccc tttctccaaa tttaccgaaa ataaagacaa 1091401 taatcaatag gaatcagaaa atttatctga aatttataaa ttgaacgtca attggcagat 1091461 ctgctccccg tacagctgag ataatctgct gcaggtcatc tttgtttttt ccggtgacac 1091521 gcacttgatc atcctgcacc tgagacttta ctttcagtcc ggagtttttg atgatcgtat 1091581 tgattttttt tgcgttgtcc ttgtcaatgc cttgaacaag ctttgcacgc tggcgcaccg 1091641 ttccgcctga cgcgttttca accttgccgt aatcaatgtt ttttgtcggt acgtttcgtt 1091701 taatcaattt gctgaccagc acatctttca gctggcttaa tttgaattcg tcatcggaaa 1091761 cgaggaccag ctcctcttta tctaaagaaa tgtcgctttt gctgccttta aagtcatatc 1091821 gggtactgat ttccttcagt gcgatttgga ttgcgttttg cacttcaggc aattccacct 1091881 tggatacaat atcaaatgaa ctttcttttg ccatatgaaa acctccataa catttaactt 1091941 atgtgttgat tatagtagaa taaagagaaa cttccaacag aacaaagaat caatttgtga 1092001 tgattggaaa aaatgttaac aaaatccgca gagaataagc ggaacaggaa ggacgatagc 1092061 atgagaccag ggcagcaatt aaccttgagt atagatcacc aaaccgactt cggttacttt 1092121 ttaaccgatg gggaagatac gattctctta cataacagtg aaatgactga ggatatcgag 1092181 gacagagacg aagtagaagt ctttatatac gtagaccagc aggaaaggct tgcggccacg 1092241 atgaaaattc cgatcatcag cgcggatgaa tatggctggg ttgaagtggt ggataaagtg 1092301 gaagatatgg gcgttttcgt tgatgtcggt ttatcgaagg acgcactagt cgcaactgag 1092361 catttgccgc cgtacgaaga tgtctggccg caaaaagggg acaaacttta ctgtatgctg 1092421 aaggtgacga accgggggcg catgtttgcg aaaccagcgc cggaagatat catcagcgaa 1092481 ctgtttaccg acgcttcaga agatctgatg aataaagagc tgacaggtac ggtgtacagg 1092541 ctgatcgcat cgggttcatt cgtgatcacg gatgacggta tccgctgttt tattcacccg 1092601 tcagaaagaa aagaggagcc aagactgggt tcaagagtca caggccgggt gattcaagtg 1092661 aaagaagacg gttcagtcaa cttgtcgctg cttccgagaa aacaggatgc aatgtcagtt 1092721 gatgctgagt gcattctaac gtatatgaga atgagaaacg gtgccatgcc gtacagtgac 1092781 aaaagccagc ctgacgatat cagagaacgt tttaatatga gcaaagccgc ctttaaacgc 1092841 gcgctgggcc atttgatgaa aaacggaaaa gtgtatcagg aaaatggatg gacatacgag 1092901 aaaaaatagc atgaaaacgg ctcgcctgca gcagactgcg gagcgagccg tttttttatg 1092961 tctagtttaa ttcatcaacc agcgttctga ttgccatttc gcgatccaca ttgtctgaaa 1093021 tcgcaatcgg cgtaatatca atggcgagaa tgatcagaat cagggcacct gctgcagcaa 1093081 cataagaaac ataatagaaa tagttagcgg tatcaacagt gttgacaagc tcggcctgaa 1093141 ctctggatgt atcatcctta gaagcggcga tttcctttgc agcttctact ttttcttcaa 1093201 cgatttgacc tgcttttttc agcagttcat ccactttcaa tgcatctttg ctgtaaacag 1093261 ctttcttcag gttatcaaaa aagtcagcat cctctttttt aatatcagcg acaacctgat 1093321 tggcaaaagc ctttgcctgt tttgtgttga gtttgtctgt catcgcttta ttaaagacct 1093381 ctggaagctg tttgccaact tccccttggg caaacacaaa gcctttaaaa atttcctcac 1093441 ctgaatactc aagctgcttt gcctgtgcca cactttcttg ctgcttcacc aaaaacacag 1093501 tcgtcaccaa tacaaccgac aaaaatacta gaaacgcctt cttcaaactg aaacctctcc 1093561 cttcttgtgt tttttattcc acaacagtct gcgaatatat gtaaattgaa tcgtggaatc 1093621 gataggagtg agatacaata tcaaaatgcc ggccatgata atcgaaaaac tgatgaggcc 1093681 cagcatgact gcaaaaatct catgcataaa aacagcgatg atcaaaatca atctccaatg 1093741 cttcttcggc gcaaacagtg ccgcgaagat gacaatttga accagcagcg tcccccatgt 1093801 cggaatcacc acgaacggac ttgttacaat tggcttcgtt aacgcctgaa aaaagccgtt 1093861 gaagccaatg gttttttcct gggcgaaata atagacggcc gttccgtcca cccattcctg 1093921 ctgagatagc ttagcgacgg tagagtgaaa ataaagcacc gccacttgga ttctgatcac 1093981 aaaataagaa ataaaagctg ttatttttcc aagtgttctt ttgccctcta taggtctcgt 1094041 actccaatgc cattttctcg gatcggtcag cgtgatggga agcaataaaa aggtcatgac 1094101 tgctgctgcc tgctcgcctc cgtcgatgac gatcagcgat gactgcaggc tgtaactgac 1094161 ataccaatgc agaaccccgg tgattctggg gcgccagcca atgacaacaa gcaccagaat 1094221 ggcaatgcag acccatctga aaagatttaa catcatatag ttattttcgc cgagacaaaa 1094281 gagactgaga ttcattttac aagctggata gctgctgatc ccgctggctg gcttcataat 1094341 gaggctcggg tgattgatga gcagcgtcag caggctggat agcgcaatga tgcttcgcgc 1094401 gaggccatat acatttgtcc acgggtttct ttcgtcccat ctggtgatgg tctgttttat 1094461 gttttcgagc atgagatcac aaccttgact atgcttttta cctgataaga cgaaggggta 1094521 tatttagaat agctccaagg aacaatatcc tctttcgtca aatagtagct gccacaaagc 1094581 agcgggcggg gagcgggtgt ttttaattgc acggttttgg ctttgctttt gcatgcgccg 1094641 aggtcctttt ctttacatgc tgtccactgt tccttgccga cttggctgta gatcacgccc 1094701 atttcaacgc cttgtgaccg cccataccga tacaggccga ataggttgtc agccctcata 1094761 ttgggccatc tgaccttggc gctggcattt tcagcctcat ataagccgat tgcagtatca 1094821 cgcggatttt tgctaaaaaa gccccagccc tgagggagga tgctggacat gagaaatttg 1094881 gagtcctttg tcagcggaat cggggttgtc cctaagctgc caataataga aaacagaaat 1094941 agcgaacccc aaaggattga aaaaatgaca aaaaatgata tcgatttctg cattcgactg 1095001 ctccttttaa cctgaagaat cgtttttaca cttttcataa tataaaaaca tttatgtaat 1095061 aaaaaggtta aaaagtatga gaaattccat ttttgttaaa aggaaaaaca ggacatttta 1095121 cactgctata tgtgattgat atatagtgtt tttttcgata tatttaaacc atgaaaacga 1095181 atcaagttaa tgaccgctgg attgttcaat ttcgaaaagg gattttcgag ctggccatcc 1095241 tatcccttct gcgttctaaa ccgatgtacg gttatgagct gacgtcatcc ttaaaaacca 1095301 cctcggcgct ggctatttca gagggagcga tttatccgat tttgaaacgt atgaccgaga 1095361 agggatggat cgaatttttt tgggaagatt cactggacgg cccgaaaaga aagtattaca 1095421 aaatgacgca aaaaggagaa gaaatgttaa aagaacggct ggagaaatac ctggaaaccc 1095481 atcaagcctt actgtcttta tcgggggatt tgctatgaat ggacagctta tcattgaccg 1095541 atacatggag gaactaaatg cagagctggc gaatatgcct gatgtagaga gagaaaacgc 1095601 tatcgacgaa ttaaaggggc atatcaccgc tttcgttcaa gacagaatca aagccggcct 1095661 tagtgaagag gaactgcagg aagctgttga atctgaattt tctcatccga aggagcttgc 1095721 cgaattgatg atgggtgatg ggggagagac gaaaaggagg aggtctttat tgggcaaaag 1095781 ctggatttcg gtccttctca ttgtcacgat tatcgccctg ccgctgctgc cgtccgactt 1095841 cagacatctg ccgctggctg tttatttaat ggtgctcgcc ggatatgtat ggaagcggaa 1095901 aaaattggtg atgtttgcag gtgtcagaaa aaacaaaatg cgctctcaaa aggagattgt 1095961 caagatttcg cgagtcggtg cggtttatct gctgttttta gcagtggtgc tccttttgag 1096021 cccgttcctc aatgcgcttg tcgtcctgct gctgattgca gtaagctgcg ccgctttttt 1096081 tctttttctt aacatcaagt aatcttgtag gaggctgtaa gatggaaatc agcatcaatt 1096141 atctattaat tgtcatcgcg cttttattct ttgtggttgc ctattttgtc ggaatcaaaa 1096201 aacaaacctg gatgttggct gggtttaacg aggcgcgtat acgggataaa gatcggctgg 1096261 ccagaatagc aggctacttt ttcttgaatt ccggtttgtt cattttgctg aatagtttta 1096321 tctcatttca aggtcaggag cagctcatac ctccgcttat actggcatat ggagcagggg 1096381 ttattattta tgtcaataaa aaattagtag agtagaaaaa gaagggcaga gcgaaatatc 1096441 tctgcccttc ttttttggga aaataagaac gaagcaccac atacaagttt ttgtattttt 1096501 gataggatga agaaaaatgg tagattccaa aataggaagg atgtggtgtt ttgcgcaact 1096561 tgaccaagac atctctatta ctggccggct tatgcacagc ggcccaaatg gtttttgtaa 1096621 cacatgcctc agctgaagaa agcatcgaat acgaccatac gtatcaaacc ccttcataca 1096681 tcatcgaaaa gtcaccgcag aagccggtac aaaacacaac ccagaaagaa tcgctatttt 1096741 cctatcttga caagcatcaa acgcagttta agctcaaagg gaatgcgaac agccattttc 1096801 gcgtttcgaa aaccataaag gatccaaaga caaaacaaac gttttttaaa ttaacggagg 1096861 tttacaaagg aattccgatt tacggctttg aacaagcggt cgcgatgaag gaaaacaaac 1096921 aagtgaaaag tttctttgga aaggtgcatc cgcaaatcaa ggacgtctcc gtcacaccgt 1096981 ctatttctga gaaaaaagca atacatacag caaggcgtga gctcgaggct tccattggaa 1097041 aaatcgaata tcttgatggg gaaccaaaag gcgaattata tatctatcca cacgacggtg 1097101 aatatgatct cgcctacctt gtgagactct cgacatctga acctgagcct ggctattggc 1097161 attatttcat cgatgccaaa aacggaaagg tcatcgagtc ctttaatgcc attcatgaag 1097221 cggcaggtac aggaatcggc gtgtcaggtg atgaaaaaag ctttgacgtc acagaacaaa 1097281 atgggcgctt ttatttggct gacgaaacaa ggggaaaagg gatcaataca tttgacgcga 1097341 agaacctgaa cgaaaccttg tttacgcttt tgtctcaact gatcgggtat acgggcaaag 1097401 aaatagtcag cggcacgtcc gtatttaatg aacctgcggc tgtagacgca cacgcaaatg 1097461 cgcaagccgt ttacgattat tacagcaaga catttggccg tgattctttt gatcaaaacg 1097521 gagcaaggat tacgtctacc gtgcatgtcg gcaaacaatg gaacaatgct gcgtggaacg 1097581 gtgtccagat ggtatacggg gatggagacg gttcgaaatt taagccgctg tctggatcgc 1097641 tcgacattgt cgcgcatgaa atcacacacg cagtcacaca gtattccgcc ggtcttttat 1097701 atcaaggaga acccggtgca ttaaatgagt ccatttctga cattatgggc gcgatggctg 1097761 accgtgatga ttgggagatc ggcgaagatg tctatactcc tggtattgca ggagattcat 1097821 tgcggtcatt ggaggaccca tctaagcagg gaaatccaga tcattactcg aaccgctaca 1097881 caggaacaga ggattatggc ggagtccata tcaattcgtc cattcacaat aaagcagctt 1097941 atcttcttgc agaaggaggc gtgcaccacg gtgtacaggt tgaagggatt gggcgtgaag 1098001 caagtgaaca aatttactat cgggctttaa catattatgt aacggcatct acagatttca 1098061 gcatgatgaa gcaagcggcg attgaagctg ccaatgattt atacggtgaa ggctcgaagc 1098121 aatcagcttc agtcgaaaag gcgtatgagg ctgtcggcat tctatgagca aacaaaaaca 1098181 gtcaggacac agagtctgac tgtttttgtt tgctcatttt cttaaaaaga atatcgccaa 1098241 tgtacctgga ccggcatgcg agccgatggc tgaactgatt ggatgcataa tgatttcttt 1098301 cggcttgaac gcttcctcaa tcaggtgttt catatccgtg gctttttctt tgttcgcggc 1098361 gtagctaatc ccgacggttt gattgctcca atcatccccg cgctctttca taagctcgat 1098421 gatccgtttg aaaagtttct tctgtccgcg aattttttcc agaggcacaa gcttgccgtc 1098481 ctccatctga agcagcggtt taatattcaa caggccgccg acaaaagcgg acgttttgga 1098541 tatccggccg cccctcgcga gatatgttaa atcatcaacg gtaaaaatgt gttcaagctg 1098601 gctgcaaaag ttctttacag acgtttcaat ttcttgtatt gtattcccgt tgatacagag 1098661 atcggcagca tgccggacag ccagaccgta tcctaatgaa gcgcatttgg aatcaatgac 1098721 ccgcaaatcg aaatcgggga attcctcctt cacttcattg gcgatcatta cagctgtctg 1098781 atacgtgccg gagagacctg aggaaaaggc aatgtaaaga gcgggatcac ctgtttcggc 1098841 atattgcaaa aacacatttt taatcgtttg cggtgaggct tgggacgtct taggcgtttc 1098901 tccattttgc atcgcttcaa atatttgatc cgcatgaatt gtgactgcat cttcgaattc 1098961 tttatcgccg agagaaaccc tgagcggaat aaagccaatg cctttttctt caaaataaga 1099021 acgaggcaaa tcagtggcgc tgtcagcgat gagatgaact gtcatattgc ttcccttctt 1099081 tccgttatcg ctcgttatca tgagagttaa gccaactata tcatattaat ttgccaaaat 1099141 cgtgttcaaa tatttgtttt aagggaaaac ataataaaga agaaagagcg gaggaacatg 1099201 ccatggtact agatcaaaca aaaaaattac tcatcgtcat catcggcgct ttactcaatg 1099261 ctgccgggct gaacttattt ttgatacctg cagatgtata tgccagcgga tttacaggtg 1099321 ttgcccagct tttatcaagc gtcgttgatc aatatgcccc cttttacata tcgacgggaa 1099381 cgctcttgtt cctcttaaac attccggtcg gtattttagg atggctgaag gtcggcaaat 1099441 cgtttacagt gtacagcatt ttaagtgtcg cactcactac tctgtttatg gggatcctgc 1099501 cggaaacaag cctgtcacat gacattttgc tgaacgcggt gttcggcggc gtcatttccg 1099561 cagtcggtat cggcttaaca ttaaaatacg gagcttcgac aggcgggctt gatatcgtcg 1099621 ccatggtact tgcaaagtgg aaggataaac ccgtcggcac gtatttcttc attctgaacg 1099681 ggattatcat cttgacggca ggattattgc aaggttggga gaaagcatta tataccctgg 1099741 ttacactata tgtgacaacg agggtgatcg acgccattca cactcgccac atgaagctta 1099801 cggcaatgat tgtgacgaaa aaagcggacg aaatcaagga agccatttac ggaaaaatgg 1099861 tgcgcggcat cacaactgtt ccggcaaaag gagcatttac gaacgaacag aaagaaatga 1099921 tgattatcgt catcacgagg tatgaactgt acgatttaga aaagatcgtc aaagaagttg 1099981 atccaaaagc atttacgaac atcgttcaaa cgacagggat ttttggtttc tttagaaaag 1100041 actgacgaaa gcaggtggaa gtcgtgaaac ggctgcttgt gatgctcctc cccgtgctgc 1100101 ttttgatagg ctgcgggaaa gatgagcaga cagaacccga taaggaggta tcaggcggaa 1100161 tggagaatca agaggttgtt ttatctattg acgcaattca ggagcctgaa caaatcaagt 1100221 ttaacatgtc gctgaagaac caaagcgaac gtgctattga gtttcaattc agcacagggc 1100281 aaaaatttga acttgtcgtg tatgattctg agcacaaaga aagataccgt tattcgaaag 1100341 aaaaaatgtt tacgcaggct tttcaaaacc tgacgcttga atctggagaa acatatgatt 1100401 tctctgatgt gtggaaggaa gtccctgagc ccggaaccta tgaggtaaag gtgacattta 1100461 agggcagggc ggaaaatctc aagcaggttc aggctgttca gcagtttgaa gtcaaataag 1100521 aggctatggc gagtcgccat agcctttttt tattgcagtt tgtccagctg attttgaaat 1100581 tgatgcaact gttgacgttc cgcatctgtc gaattggcat acgcagaaga tacagcattt 1100641 ttggctctca gaatcgcttg ctcctgatcg ccttcctcaa agccgtttgt caccatgacc 1100701 gcctgttgaa caaatgattt tgcctgctga aacagttcat ttctcattta atattcatac 1100761 tgcctttcag ccgagtctcg tgccgcggca tgctggtgag cttcttctaa agtagaccga 1100821 tatggaaatc ttgcggcgtg tagcccgatg gagtctttac cctgctgaat aaaccttctg 1100881 gatttgcttc gtttacccat tttgagactg cccccttcca tactttgacg agatgagtcg 1100941 tcttcaatag tatggtgggg taaagtaagg tttatgagtg ggaaaaatta atacggacct 1101001 tctttaaagt gagaaatatt ctttcaaaaa ccttgccacg ccgtcctctt catttgtggc 1101061 cgtagttcgg ttggcaatct gcttgaccgc gtcaattcca tttcccattg caacgccgca 1101121 gcctgcaaat tcaagcattt ccaaatcgtt atcctcatct ccaaaagcaa tgatccgctc 1101181 cctcggcacg ccgtaataat cgctgatttt ctgcaggccg accgctttat tcatgccgct 1101241 tttgataatt tcaatgacat gccaaggagc ggcccatctt ctatggtcga tcacctcggc 1101301 atgcacatcc gataaatatg agcgtattgc cggcacatcc tcttcctttg catgtatgag 1101361 tacggacgtc acatcttcac cgagattttc ccgcaagtct ccgaccgtta catttgttgt 1101421 gttcatgtta aaggcatcta tcaggtgctc atcatggtaa tgaaagtata cgtcgtcaat 1101481 cacttcagca agcacgttat gtacgttgta gctctcgctg atatccacga gctgtttgac 1101541 aacatcaagc ggcagtgacg tatgataccg tccccagctg tcgtcttgcg gatgatggac 1101601 aaatgctccg ttaaaattga caattggcgt tgtcagctcc atctgctggt agtacatgga 1101661 acttgaacga tacggacggc ctgttgagat gcagacataa tgcccgtcat cttttaggcg 1101721 ctgtatcgta tgaagggtgt tttcagatat ggttttatca tcctttaata atgttccatc 1101781 taaatctaat gcgattaaat agggttttgt ctccatgaaa agctccttta accttagatt 1101841 ttgcttgttt tgccttactt acagtgtagc tttttaccat ctttattgtc tacatgttac 1101901 acttatgatt atggttatcc taaggagggg cacattgtga tacaaattga gaatcaaacc 1101961 gtttccggta ttccgttttt acatattgta aaggaagaga acaggcaccg cgctgttcct 1102021 ctcgtgatct ttatacatgg ttttacaagc gcgaaggaac acaaccttca tattgcttat 1102081 ctgcttgcgg agaagggttt tagagccgtt ctgccggagg ctttgcacca tggggaacgg 1102141 ggagaagaaa tggctgttga agagctggcg gggcattttt gggatatcgt cctcaacgag 1102201 attgaagaga tcggcgtact taaaaaccat tttgaaaaag agggcctgat agacggcggc 1102261 cgcatcggtc tcgcaggcac gtcaatgggc ggcatcacaa cgcttggcgc tttgactgca 1102321 tatgattgga taaaagccgg cgtcagcctg atgggaagcc cgaattacgt ggagctgttt 1102381 cagcagcaga ttgaccatat tcaatctcag ggcattgaaa tcgatgtgcc ggaagagaag 1102441 gtacagcagc tgatgaaacg tctcgagttg cgggatctca gccttcagcc ggagaaactg 1102501 caacagcgcc cgcttttatt ttggcacggc gcaaaagata aagttgtgcc ttacgcgccg 1102561 acccggaaat tttatgacac gattaaatcc cattacagcg agcagccgga acgcctgcaa 1102621 tttatcggag atgaaaacgc tgaccataaa gtcccgcggg cagctgtgtt aaaaacgatt 1102681 gaatggtttg aaacgtactt ataaagcact aagttattaa caagagctga atttacgtta 1102741 tactgtagaa aaaaggagtg agggaacgtg gaagaagcat taaaagaaaa catcatgggc 1102801 gccctggaac aggttgtcga tcctgagctt ggcgttgata tcgtgaacct cggcttggta 1102861 tatgacgttg atatggatga agatggcttg acgcacatca ccatgacgct aacatcaatg 1102921 ggatgccctt tagcgccgat tatcgtggat gaggtgaaaa aagcattagc ggaccttcct 1102981 gaagtgaaag acacagaggt tcacattgta tggaatccgc cttggactag ggataaaatg 1103041 tccagatacg caaaaattgc gcttggcatt caataaaaca aaaaaggaca gcctgacatg 1103101 tgaggctgtc cttttttaca gctgaaagga gtgaaaggaa atgatgtacc tgctggcagt 1103161 tttatgcccg ccgcttgctg ttttgttttc gggaaaaccg tttcaggcct tgctgaatct 1103221 catattgacc tgtatctttt ggctgccggg cgcgattcac gcctgcttta tcgtcgccga 1103281 ccgccgtgcc gaaaaacggg caagaagata atttggaaaa atgaggacgc agtcatggta 1103341 taatggtcat aaaaacagca gggagagcac tatgaaaaag aaattgcttg cattcgcgct 1103401 ttgtactggc gcgtatgcgg ccctgtttgc gtactctgtg aactcagagc aaaaaacagc 1103461 cacaagcgag atgacggatg tcagccgcct gatgcctgta aaaataaagc agacagtgaa 1103521 agggcaggaa gaggaaatgc tcattgacac agtcaaagag gcaaatcgaa aaaacataaa 1103581 aatttcaatc gccggggccc agcactccat gggcggccat acatattatg aggacggcat 1103641 cgttctcgac atgacgggct acaacaaaat cctgtcactc gatcaagaga agaaaaccat 1103701 cagggtgcaa agcggtgcaa cgtggaatga tatccagaaa tacgtgaatc catacggact 1103761 cgcggtaaaa gtcatgcagt cacaaaacat ttttacaatc ggcggatctc tcagcgcaaa 1103821 tgcacacgga cgtgatattc gctacggctc gctaattgat acagtcaaat cattccggct 1103881 tttaaaagct gacgggatga ttatcactgt cactccaaaa gatgatttgt ttacggcggt 1103941 catcggaggg tacggccttt ttggcgtgat tcttgatgta acgcttgagc tgacagatga 1104001 tgagctgtat gtcatgaaga cagaaaaaat gaattacagc acatactcag actatttttc 1104061 aaagcatgta aaaggaaatc cagatgtccg aatgcatctg gcgcgaattt caacagcgaa 1104121 aaaaggattt ctgaaagaca tgtatgtcac gaattacgta ttggctaatc atcaggatca 1104181 gctgtcctca tacagcgaac ttaaagaaga cgagtatacg ggagccacaa agtttgcact 1104241 cggcttgtca agacggtatg aatgggggag gaattggctg tgggacacac agcaatccta 1104301 tttcctgagc cagaacggca cagagatttc acgcaataac gtcatgcggt ccgaatcaaa 1104361 gtttcttgag tatgaaaaca atgacaacac agatgttttg caagaatact ttgtgcccgt 1104421 gaaggagtat gggtcctata ttgatgacct gagacaaacg ctgtcggacg aagatctgaa 1104481 cctgctgaac attacgatcc gctacgtgca gaaaaatgaa aaggccgacc tttcctatgc 1104541 gaaggacgat atgttttcgc tcgtactatt aataaacgag ggcttttcaa aagaagacca 1104601 ggcagatacc gcccgaatca tcaggcgcat gacagacgtt gccatcaagc acggcggcag 1104661 ctattatctg ccttatatga cctaccagac aaaagcgcaa atgagacagg catatccgaa 1104721 aagtgaagcg ttttttcaga aaaaacgaac ctatgacccg gatgagcgct ttatgaatta 1104781 cttttatcag aggtataaat aatggggaaa aacaaattaa aatggctgac attatcacaa 1104841 agcagcgtgt ttttcgcaag cagcttaatc tttccgtttt atattctgtt tgtgaaaaat 1104901 atcggctcaa gctacacaca gttcggtttt tcctacggat tgttcgggtt gagcggagcg 1104961 cttatttacc cgctcctcgg acggctgtct gaaaggtttg acagccgtta ttttctgctt 1105021 ctgaactcgt gggggatggc tgttctgctt ttatatgtcc cgcatatcgg aagcgtcgtt 1105081 caagtgtata tcgtccaagt gctgttaggg ctctttggag cgatgcaaaa gcatggagaa 1105141 aaagtgctga tcgctaattt tacagacagt ggagagcgtg gaaagaagat cgggaattac 1105201 catttttgga cagctgtctt ttcagcagca gccattatgc tcgggggctt tctcgctgac 1105261 tttttcacag tgcaaatgat tttttatgca agctctattc tatatttttt gagtggattg 1105321 atgatgatga aaacaggctg acgcggtcag cctgtttttt tatgcggctg aaatgcggca 1105381 ccgcatcaac gtttttgtgc tggagtcgtg ctgatttttt ttgagcggaa ttcccattga 1105441 acagaaaatt tataaatgaa taaaaatatt aaatatacga ttgaattaat ttttattcat 1105501 gttataatgt taaataattt cacaaagacc aagagggtga acttgttttg aaaataggaa 1105561 ttgtaggtgc tacaggatat ggaggcaccg aacttgtcag gattctttcg catcatcctc 1105621 atgcagagga atgcatactt tattcatcca gcggagaagg gaatgtctat agcgagggtt 1105681 atcctcatct taccggctta gcggatcagc agctgaagcc gattgatatg aatacgatca 1105741 aacacgaaat agatatcatg tttctcgctg cgccgcccgg agtatcaagt gaattgactc 1105801 caaagctggc agacgcggga attacggtta ttgatctgtc aggtgatctg aggataaaag 1105861 aaccggctga atatgaaaaa tggtataaac ggacagcggc accgaaggcg gtgattcaag 1105921 aggcggtata cggtctggca gaactgaatc aactgcaaat tcaacaggcg aaactcattg 1105981 ccaatccagg ctgttttcca acagctgttt tgcttggcct cgcgccattg gctcaaaaga 1106041 aactgctcga tgaatctttc gttatcgttg acgcgaagac cggtgtttcc ggagcgggaa 1106101 gaaaagcatc catgggaact catttttctg agctgaacga caattttaaa atttataaag 1106161 tcaatgaaca tcagcacacg ccggaaattg agcaggcgct gaatgaatgg cagccaggtc 1106221 tcgggcccat tacattttcg gctcacttgg ttccgatgac aaggggcatc atggcgacga 1106281 tgtataccag attaacctgt gacctaaccg cagatgacct gcatgattta tattcggaat 1106341 tttaccaaga ttcatatttt gtgagagtga ggccaaaagg tcagtacccg caaacgaaag 1106401 aagtgtacgg cagcaatttc tgtgatatcg ccgtgaccct cgatgagaga acgaacagag 1106461 tcacgatcgt ctcggtaatc gataatttaa tgaagggtgc cgccggtcag gcagtgcaaa 1106521 actttaattt gatgaatggc tggaatgaag aaactggact caccatcacg ccaatttatc 1106581 catagaacgg gagagaatcg aaccatgatt cagttaagtg aagatcaaat tgtaaaagta 1106641 acaggtgatg tatcctcgcc aaaagggttt caggcaaagg gtgtgcattg cggactgcgc 1106701 tactcgaaaa aagacctcgg cgtcattatc agcgagacac cggccgtgag tgcagcagtt 1106761 tatacccaaa gccactttca ggctgctccg atcaaagtga cacaagacag cttaaagcac 1106821 ggaccgacac tgaaagccgt catcgtcaac agcgccattg ccaacgcctg cacgggagaa 1106881 cagggcttaa aggacgcata cacaatgcgg gagagctttg cttcacagct tggcattgag 1106941 ccggagcttg tcgctgtttc atcaacgggt gtcatcggcg agcatttaga catggaaaaa 1107001 atccacgcgg ggatcgaact gctgaaagaa acacctgcgg gatcaggcga ttttgaggaa 1107061 gcgattttaa caactgatac ggtgatcaag cagacgtgct atgaactggc aatcggcggc 1107121 aaaacagtca cgatcggcgg agcggccaaa ggctctggga tgatacaccc gaacatggcc 1107181 acgatgctgg gatttgtgac aactgacgcg gcaatcgaag aaaaagcgct gcaaaaggcg 1107241 cttcgggaaa tcactgacgt ttcatttaac caaatcacag ttgacggaga aacatccacg 1107301 aacgacatgg tattagttat ggcgaatggc tgcgccgaaa acgagtgcct gacagaagac 1107361 catccagact ggccggtctt taaaaaagcg ctcttgctca cttgtgagga tctagctaaa 1107421 gagattgcca gagacggaga aggcgcgaca aaactaattg aagcccaagt acagggagcg 1107481 aaaaacaatc ttgatgcaaa cgtcattgcc aaaaagattg tcggctcaaa tcttgtaaaa 1107541 acggcagtat acggaacaga tgccaactgg gggcggatca tcggagccat cggacactcc 1107601 gcagcacagg tgacggcaga agaagtagag gtttatcttg gcggccaatg cctgtttaag 1107661 aataacgaac ctcagccatt ctctgaatct atcgccaagg aataccttga aggagatgaa 1107721 atcaccattg tcatcaagat ggctgaaggg gacggaaacg ggagagcgtg gggctgtgac 1107781 ctgacctatg actatatcaa aattaacgcg agctatcgca cgtaataaag gggagcgaaa 1107841 tgaagaaaac aatcgttttt aaatgcgggg gaagcgtcat ccgtgagctg tcggaggaat 1107901 tttatcaaaa tctgaaagag ctgagggcgt caggctggaa gctggcaatc gtacatggcg 1107961 ggggaccgga aatcacaaat atgctgaaac ggttaaatat caagacagag ttttcgggcg 1108021 gacagaggaa aacaacgaag ccggtgctgg aagtggcgga aatggtttta tccggttctg 1108081 tcaataaatt tttcgttgct gagcttgcca aacacggact gcgagccgcg ggcatttctg 1108141 gtaaggatgg cggtcttttg gaggctgatt atctagatcc ggaaacatac ggagaagtgg 1108201 gagaaatcaa aaaagtcgat gcgtccatgg tgaacgcgct gatggaaaat ggcatcatcc 1108261 ccgttattgc gccgctgtct atgacaagcg actgcaaaac gctgaatgta aatgctgatc 1108321 tggctgcttc agcagtcgcc ggagcgcttg aagccgataa gctgatgttc gtcacggatg 1108381 tcgatggaat catgaaggaa aagcagcgtc tggacgtcct gacccctaag gagattcaga 1108441 tgctgatcaa gcaggaagtg atcacaggag ggatgatccc gaaggtcaat tcagccttgt 1108501 cagctttatc agatcaggtg tctgaagtca tgatcgtaaa cggtaaagga tcattcttcg 1108561 cagaacaaac ctttcaaggg acaaaaattg tcaaagcaaa ggaggctgtt tcatgagcag 1108621 cttgtttcaa acctacggcc gttgggatat tgacatcaaa aaagcaaagg gaacgtacgt 1108681 tgaggatcaa aacggcaaaa cgtaccttga tttcattcag gggattgcgg tatcaaatct 1108741 aggacactgc catgaagcgg tgacagaggc agtcaaaaaa cagcttgaca gcgtatggca 1108801 cgtatccaac ctgtttcaaa acagtctcca agagcaagcg gcgcagaagc tggcagcgca 1108861 tagtgcggga gatcttgtct ttttctgcaa cagcggcgcg gaggcgaatg aaggtgcgat 1108921 aaagcttgcc agaaaagcaa ctggaaaaac aaaaatcatc acttttcttc agtcgttcca 1108981 tggccgcacg tatgcaggga tggctgcgac cggacaggat aaaatcaaaa caggcttcgg 1109041 cccgatgctt ggaggctttc actacctgcc atacaatgat ccttctgctt ttaaagctct 1109101 tggggaggaa ggcgatattg ccgcggtgat gcttgaaaca gtgcagggag aaggaggagt 1109161 caatccggcg agtgctgaat ttttatcagc cgtacagtcg ttttgcaagg aaaagcaagc 1109221 ccttctcatt attgatgaaa tccagaccgg catcggacgg acgggaaaag gcttcgcata 1109281 tgagcacttc ggactctcac cggatatcat cacagtcgcc aaaggattgg gaaacggctt 1109341 tccggtcggc gctgtcatcg gaaagaaaca gcttggagaa gcgtttaccc ctggttctca 1109401 cggaacgact ttcggaggaa acatgctggc gatggctgct gtgaatgcca cattgcaaat 1109461 tgtattccag cctgactttt tgcaagaggc tgctgacaaa ggggcgtttt taaaagaaca 1109521 gcttgaggca gagctaaaga gcccttttgt taaacaaatc cgaggtaaag gattaatgct 1109581 tggaattgag tgtgatggcc cggttgctga cattattgct gaattgcaga cattaggctt 1109641 gcttgtattg ccggccggcc cgaacgtgat tcggctgctg ccgccgctca ccgtgactaa 1109701 ggatgaaata gcagaagccg tcagcaagct gaaacaggca atcgctcatc attccgctgt 1109761 aaaccagtga ttttttttcg atataaaggc ataaaaattc atttttataa ttaattattc 1109821 atcaagaggt gggctgttag atggaaggtt atttagtgtt agaagatggg acatcgttca 1109881 gcggcgagct ggacggtcat gaaaactgca cgggagaagc tgtttttttc acaggaatga 1109941 caggctacca ggaagtgctg acagatccat catataaggg acagattatt gtatttacct 1110001 acccgctgat tggcaactac ggcataaatg aaaaggattt tgaaagcaag aaaccgcaag 1110061 taaaagccgc ggttgtctat gaggcgtgtg atcacttttc tcattatgaa gcggtataca 1110121 gcctcaagga gtatctacag aaatggaata ttccgctgtt aacccatgtt gatacgaggg 1110181 ctgtcgtgaa gaaaatccgg gcaaacggga cgatgggtgc gacagtcaca gcctctaaag 1110241 aaggagctga gattgccctt caaccagaga atgtggcaga gcaggcttcc gcccaggaaa 1110301 tcagcacatt cggcgacggg aataaacata tcgctctcat tgattttggc tataaaaagt 1110361 caatcgcatc atcacttgtc aaacgaggct gcaaggttac cgtggtgcca taccagcaaa 1110421 tggaggccgt atacaacatc aaacccgatg ggctatcgaa cggacctgga gatccgaaag 1110481 ccattcagcc atatttagga aagatcaaaa gcatcatcag ccgctttccg actctaggca 1110541 tttgtctcgg acatcagctg atcgcgctcg cgtttggagg gaatactttt aagctgccat 1110601 tcgggcacag gggagctaat catccggtca tcgaccgtaa gacgaaacgg gtctttatga 1110661 caagccaaaa ccacagctat gtggttgatg aacagtcgat taatgaagaa gagctcacca 1110721 tcaggtttca tcatgtcaat gatacgtcag ttgaagggct tgcccataaa aaactgcctg 1110781 tcatgagtgt tcaattccac ccggaagccc atcccggacc tgcggaaagc gaatggattt 1110841 ttgatgatta tctaaagaat gtgataccag caaggagaga aatcgcgcat gcctaaagac 1110901 accagtattt caagcatatt agtaattggc tcaggcccga tcatcatcgg gcaggcggca 1110961 gaatttgatt attcaggcac tcaagggtgc atcgcgctga aggaggaggg ctaccgggta 1111021 attctcgtca acagcaatcc ggcgacaatt atgactgatg aagccttcgc tgatgaaatt 1111081 tattttgagc ctctgacagc agaaagcctg acagccatca ttaagaaaga acggcctgat 1111141 gggcttcttg ccaatttagg cggtcagacc gcgttgaatt tagcggtgga gcttgaagaa 1111201 acgggtgttt taaaagagca cggcgtcaaa ctcctcggca catccgttga aacgatacaa 1111261 aaaggagagg accgggaaaa attccgttcg ttaatgaatg aattaaaaca gcctgtgccg 1111321 gagagtgaaa ttgttgataa cgaggccgat gccctccatt ttgcggaatc catcggtttt 1111381 cctgttatta tcagaccagc ttacacatta ggcggaaagg gcggaggaat cgcccctgat 1111441 aaagaagcct ttacagctat gattaagcag gcgctattag caagcccgat caatcaatgc 1111501 cttgtcgaaa aaagcattgc cggctttaaa gaaattgaat atgaagtcat gcgtgacagc 1111561 aataacacat gcattaccgt ctgcaatatg gaaaatatcg atccggtcgg cgtgcataca 1111621 ggtgactcta tcgttgtggc gccgtcacaa acattgacag acgaagacta tcaaatgctg 1111681 cggacagcaa gtctgacgat catctcagca cttgatgttg taggcggctg caacattcaa 1111741 ttcgcgcttg atccattcag caagcaatat tacgtcattg aagtgaatcc gcgtgtaagc 1111801 cggtcatcgg ctctcgcatc taaagcgacc ggttatccga ttgcgaagat ggccgcgaaa 1111861 ctggcagtcg gatacactct tgacgagctg aaaaatccgc tcacaggctc gacttacgca 1111921 agctttgaac cggcactgga ttatgtgatc gtcaaatttc cgcgctggcc gtttgataaa 1111981 ttcaaaaacg cagaccgcaa gcttggcaca aaaatgaaag ccaccggtga agtgatggcg 1112041 attgaacgga atttagaagc ggcgatacaa aaggcagccg cgtcgcttga attaaaaaat 1112101 atcgggacac accttccaga gctcagcggg ttgtcaattg atacgctatg ggatttggca 1112161 atcactccgg atgaccgcag atttttcgtt gtcatggagc tgttgagccg cagcgtctcg 1112221 attgatgaca tccatgaaaa aacaaaaatt gatccgtttt tccttcatac ctttgacaac 1112281 atcatcaaat tggaaaaccg cctgatggaa gcagggagcg atctctcttt tgaattattg 1112341 aagaaagcaa aggaaaaggg attctcagac gcaacgattg cctcgctgat cagcaaaaca 1112401 gaagaagagg tgcgcgcgct tcgcaaggag atgggcatta cgccttcctt taaaatcgta 1112461 gatacatgcg cggcagagtt tgatgcgaaa acaaactatt tttactccac atatttcgga 1112521 gagaccgatg gagacatcag ccgcaaagag aaaaaacgcg cgctcattat cggatcaggc 1112581 ccgattcgga tcggccaagg cgttgaattt gattacagtg ctgttcacgg tgtgctgaca 1112641 ctgcaagagc ttgggttcga aaccatcatg attaacaata acccggaaac tgtcagcacc 1112701 gattatgaaa ttgcggaccg cctgtatttt gaaccgatga caacggagca tattgtaaac 1112761 gtggcggagc aggaaaatat tgattttgca attgtgcaat ttggcggtca aactgcaatc 1112821 aatgctgctg aagcgctcga aaaagccggc attactcttc ttggcacatc atttcaaacg 1112881 ctcgacgtgt tagaggatcg ggatcaattt tatcagcttc ttgacgagct gggattgaag 1112941 cacgcaaaag gagaaattgc ttatacaaaa gaagaagccg cttcaaaagc gagtgagatc 1113001 ggctatccgg tgttaatccg cccatcttac gttatcggcg gaatgggcat gatcattgtt 1113061 gactcgcaag cccagctttc tcagctgctg aatgatgagg acagcatgcc atacccgatt 1113121 ttaattgatc agtatgtgtc tggaaaggaa gtcgaaattg atttgatttc cgacggcgag 1113181 gaagtcttta tcccgacata taccgagcat attgaacggg caggtgtcca ttcaggggac 1113241 agttttgcca ttcttcccgg accgtccatc acgagcgggc tgcagcaggg catgaaagat 1113301 gcggcacaaa aaattgcccg aaaactttca tttaaaggca tcatgaacat tcaatttgtg 1113361 atcgacaatg gaaacatact cgttcttgaa gtgaatccga gagcgagccg cacggttcct 1113421 gtcgtcagca aagtaatggg cgttccgatg attccgctcg ccacacgtct gctggcggga 1113481 gcgtccttaa aagatctaaa tccggcagtt caaaatcatc atggagttgc cgtgaagttc 1113541 cctgtttttt cttctcatgc gatccaggat gtggatgtca agcttggacc ggaaatgaaa 1113601 tcaacgggag aaggcatgtg tgtcgcatat gattctaaca gcgccttgaa aaaaatctat 1113661 acaagagtct ggagtcaaaa aggaagcatt tatttgcaaa acgttccgga agatgtgaag 1113721 gagttagcag aaaacgcagg ttttacaata catgaaggaa catttgcctc atggatggaa 1113781 caggaaggaa actcgctcca cattaatctg agcggttctg aagaagcacg caaagaacgt 1113841 ttggaagcca tgacgcacgg catccccgtc tttacagaag aagaaactgt gcgggcgttt 1113901 ttacaaagcg gttcaggcca tccgcagcct gtatctctca aagacctcta taaaaaggaa 1113961 gtggcatcat gcacacagtg acgcaaacca gtttatacgg aaaagattta ttaacgttaa 1114021 aggaccttag tgaagaagat ataaacgcct tgctcgcaga agccggtgag ctgaaacaaa 1114081 acaaaattca gcctatattc catggcaaaa ccttggcgat gatttttgaa aaatcatcaa 1114141 cgcggacccg tgtttcattt gaagcgggca tggcgcagct gggcgggagc gccctctttc 1114201 taagccagaa agatctgcag ctggggcgcg gtgagactgt cgctgatacg gcaaaagtgc 1114261 tgtcaggcta tgtggatgcc atcatgatcc ggacctttga acatgaaaag gtggaggaac 1114321 ttgccaaaga agctgacatt ccggtgatca atggacttac cgataaatac cacccatgcc 1114381 aggcgctggc ggatctcttg acgattaagg agataaaagg gaagcttaaa ggcgtaaaag 1114441 tcgcgtacat cggtgacgga aataacgtgg cgcactcctt gatgatcggc tgcgcgaaaa 1114501 tgggctgtga tatctcgatc gcttcaccaa agggatatga agtgttagat gaagcagctg 1114561 aagcggcaaa gacatatgca cttcaatccg gctcttctgt cacgctgaca gatgatccga 1114621 ttgaagctgt aaaagacgcg gacgtgattt attctgatgt gtttacaagc atggggcagg 1114681 aagcggaaga gcaagaacgt cttgctgtct ttgcgcctta tcaggtgaat gcggcgctgg 1114741 tcagccatgc caagcctgac tatacatttt tacattgtct ccctgcgcat cgcgaggaag 1114801 aagtgactgc ggagattatt gacgggccga actctgcagt gttccagcag gcggaaaacc 1114861 gtcttcatgt gcaaaaagca ctgctgaagg ccattttata taaaggggaa tcatcaaaaa 1114921 actgctgagc caaactcagc agtttttttg atggcaacat attcacagcc gcttaggcgc 1114981 atactacagc aaaaaggaaa aggaggaaaa acagtgggac agcagcacca attccggccc 1115041 ggacagaaag cgcctaataa cggtgtctac gtagaaatcg gcgagacagg gagcatggtt 1115101 aaaaaccctc aaaaggtcca tctgtcagca ggggaaatgt tccccgaaac atcaaaccac 1115161 aaccggctgt ggacctacaa aagaaagccg tgaccactaa aaaacccaaa acaataaatg 1115221 ttttgggttt ttggcttttt aatgctggct tgcatttttg ttcataggca tgatttctgc 1115281 taaaaccatg attaagacat acagtacaac agcaatgaca gatgatgttt tgaaattata 1115341 cgtaacgctg ttcatgcttg caaccaagta gcatgccata tgtgataaaa ggaacgtcca 1115401 aataaaggca ataatatatc gcacgtttcc acctcgtcct tctcattcta ttctaaaagt 1115461 tatcatacca tacaaaaagc gaagggggaa tccaatttta gcagaaagtg aggtgacaaa 1115521 agagtctgat tcgtcacact ttaatggtaa aatataaaac gtcaatcagt ataatagcca 1115581 aaaatgtaaa aggctaggac tttaccttat tcgtttcttt tctatttaca taagatagcg 1115641 tgagatgaag tgtgaaagga ggcgggcaag cgatgggaat aacggaaaga tactttcaac 1115701 tgggaacgga gcataatgtc attcatctgc cctatcgccc gaacggcttc ggcatcttta 1115761 tcttggggga cagaacccac tttgtcggac atgattcaag cttttggcag cagcattatg 1115821 gcagaaatca gcttctgagc atgttgatga atgaaggata cactcttttt aacagcaatc 1115881 tgttcggaag gcattggggg gcggaaaaag cagtcaccta tgccaaacag ctgatacatt 1115941 ctgtgctgaa gcaggaaatc ctcaatccga agattcatat tttagcagaa ggcatgggtg 1116001 ctctcgtggc cgatgaactg cttcgttttt ccccggatca tatccgctca gccgcaatgt 1116061 tgaatccttg tctcgatctt caggcacatt atgaatcgga aaaagaaaat aaatttttct 1116121 ataagcaatt tttgaaagaa gtatcgaaaa gctacggaat ttctgaaaaa gaagcggaag 1116181 cgattcgtta taaaacaatt caaagctacc cgagcggcgt accggttcat atatggcagc 1116241 gtatgaccgg agctccatat ccctacagcg tacatgcgga agttttcaag gaaaaacagc 1116301 aaaagcaagg ctcaccggtc gacatgacat ttcatttatt tgagcatcca agcagaattt 1116361 atgcatcaat ttgcaaattc tttcatagtc atgaaaaaga attatagaga atataatgac 1116421 aacagccttc tcttttgcgg aggctgtttt gttttgggaa atgaaaaacc ggaagggcgg 1116481 cagatgcaat ggaatcaacg ctgattgtag gtgcggacga atttttcggc ctttcattat 1116541 gtgagcgaat gatggatgaa ggcatacatg ttgacgttgt tctggcggaa acagaagata 1116601 aaatgagaca aatgtactta gaagaaagac tcatgtggct tgggagaaat gaactctttc 1116661 gccagcttga acacattgga gaccaaaatt atgatacaat ttgtatccag ttcggaagtt 1116721 ttttgccttt agaccaatat gattctcctt atattttagt atatgaagaa gaccgaaaag 1116781 aatgggataa acgtgaaaaa acaggctcgg aaaaaaccgt gatcctgccg aaaatgtacg 1116841 ggccatggaa agaagaaaca gaggaagacg gctattacac aaacgacgtg gctgacgagt 1116901 tgctgagatt cctgttagaa ccaagccgtc atagcaaaga tcagcttttt gaattgcaag 1116961 tcacagagaa aacctcaaaa gaagaagcaa aaacaaaaat tatcgagtgg aaaagacaat 1117021 tttcatcaat tttcgacaaa tattaagaaa aaccttccat gtttcgagtt ttctagatac 1117081 aataaacgta taaaaataat acatgttata gcttgtcaaa aggagttgaa catgacttga 1117141 tcacaaggct tgtcatgatc ttttctgtcc tccttttatt gagtggatgt ggacaaactc 1117201 cgttcaaagg aaaaattgag aaggtcggca tgctctttcc tgatacgatt aatgacctcg 1117261 tatggggcac aaaagggtat aaaggattac tgaatataca atccaaatac aatgtggacg 1117321 tctattataa agaaggcgtt aaaacagaag aagatatcat aaatgcgatt gaggattttc 1117381 ataagagggg cgtcaatctg ctctacggcc atgggagtga atatgctgag gtgtttaact 1117441 tggtcggcga agattatcca gatatggaat tcgtcatttc caatgcgaaa gcgaaagctg 1117501 ataatgtaac aagtgtccat tttagcgggg aagcaatggg cttttttgga ggaatgactg 1117561 ctgcccatat gtcgaaaacg aatcaggtcg gtgtaattgc ttcctttacg tggcagcctg 1117621 aggttgacgg ttttatcaaa ggggccaagt atgaaaatcc ggatatagag gtaaatacga 1117681 aatatacgga tcattgggat gatgatacaa cagcagtaaa gctttatcag aaaatgaaga 1117741 acgaaggcgc ggatgttgtg tatcccgccg gagacgggta taatgttcct gttattcagc 1117801 aaatcaaaaa agacggtctt tatgccatag gctacgtcac agatcaatcg gatctgggcg 1117861 agaataccgt attaaccagc acggtgcaaa atgtggacaa ggcctatgaa atcattgctg 1117921 aacaatttaa taaaggcacc cttgagggcg gcgatcatta ctacgacctg aacacgggag 1117981 tcgttgagat gggaacattc agcccgctcg tcgatcaaga ctttcagcaa agaatcgcca 1118041 agctgatcaa aacatacaac aaaacaggcg agctgccaaa aaacgagtaa tggagtgacg 1118101 tcacatgcag cacgaaaaat cacttgaatt cttgcaaatt gccatgaaat atctccctga 1118161 agcgaaagaa cagcttgaga aatcaggcat tgagctctca atggaggcca tccagccgtt 1118221 tatgaatcta tttacaacgg taatggcgga agcttatgag cttggcaagt ctgacgctaa 1118281 atctgaaaca gaataagaag aagccacttt tttgaaagtg gcttttcaca tgattttctt 1118341 tttaatagcg gagagcatgg gcgcaagctc ctttaaagcg ggcttgattt gatcaagaga 1118401 gttcataatt gaaccgattt ggtccataat atgcatgtaa ttaatcgtct cttcgtcgtt 1118461 tgtctgagaa acctgagaaa cttcctcttg ctgttcctcc tccttctctt ctgttggttt 1118521 tgctgcatcg ccgaacatca ttcttgaaaa cacatccaac tgcatacgcc tcctttccat 1118581 ataccatact ctatgagtaa gatgaactga tagtttagac gaatatattg ccatgtgaaa 1118641 aaaaatagga tagaattagt acctgatact aataattgat cacaacctga ttgatcttct 1118701 aaatttaaga tataaaggag tcttccctaa tgaaagctgg aatacttggt gttggacgtt 1118761 acattcctga gaaggtttta acaaatcatg atcttgaaaa aatggttgaa acttctgacg 1118821 agtggattcg tacaagaaca ggaatagaag aaagaagaat cgcagcagat gatgtgtttt 1118881 catcacatat ggctgttgca gcagcgaaaa atgcgctgga acaagctgaa gtggctgctg 1118941 aggatctgga tatgatcttg gttgcaactg ttacacctga tcagtcattc cctacggtct 1119001 cttgtatgat tcaagaacaa ctcggcgcga agaaagcgtg tgctatggat atcagcgcgg 1119061 cttgtgcggg cttcatgtac ggggttgtaa ccggtaaaca atttattgaa tccggaacct 1119121 acaagcatgt tctagttgtt ggtgtagaga agctctcaag cattaccgac tgggaagacc 1119181 gcaatacagc cgttctgttt ggagacggag caggcgctgc ggtagtcggg ccagtcagtg 1119241 atgacagagg aatcctttca tttgaactag gagccgacgg cacaggcggt cagcacttgt 1119301 atctgaatga aaaacgacat acaatcatga atggacgaga agttttcaaa tttgcagtcc 1119361 gccaaatggg agaatcatgc gtaaatgtca ttgaaaaagc cggactttca aaagaggatg 1119421 tcgacttttt gattccgcat caggcgaaca tccgtatcat ggaagctgct cgcgagcgtt 1119481 tagagcttcc tgtcgaaaag atgtctaaaa ctgttcataa atatggaaat acttctgccg 1119541 catccattcc gatctctctt gtagaagaat tggaagccgg taaaatcaaa gacggcgatg 1119601 tggtcgttat ggtagggttc ggcggaggac taacatgggg cgccattgca atccgctggg 1119661 gccgataaaa aaaggtgagg tgcacacaag atgactaaaa aaagagtagt tgttacagga 1119721 cttggagcat tatctccact tggcaacgac gtcgatacaa gttggaataa cgcaatcaac 1119781 ggtgtgtccg gaatcggtcc gatcactcgt gttgacgctg aagaatatcc ggcaaaagtt 1119841 gccgctgaat taaaagattt taatgttgaa gattatatgg ataaaaaaga agccagaaaa 1119901 atggaccgct ttacacaata tgcggttgtg gctgcgaaaa tggcggttga agatgcagat 1119961 cttaacatta ccgatgagat cgcgccgaga gtcggtgttt gggtaggctc cggtatcgga 1120021 ggacttgaaa cactagagtc tcaatttgaa atcttcttaa caaaaggccc aagacgggta 1120081 agcccgtttt tcgtgccaat gatgattcct gacatggcga caggccagat ttctattgca 1120141 ttaggagcaa aaggggtgaa ctcttgtacg gttacagcat gtgctacagg aacgaactcc 1120201 atcggtgacg cgtttaaggt tattcagcgc ggtgatgcag acgtgatggt cacaggcgga 1120261 acagaagcgc cgctgacaag aatgtcattc gccggcttta gtgccaacaa agcgctgtct 1120321 actaatccag atccgaaaac agcgagccgc ccgtttgata aaaaccgtga tggctttgtc 1120381 atgggggaag gtgcagggat tatcgttctt gaagaacttg agcatgccct ggcccgcggc 1120441 gctaaaattt acggagaaat tgtcggctac ggctcaaccg gagacgctta tcatatcaca 1120501 gcgccggccc aagacggtga aggcggagcg agagcgatgc aagaagccat taaagatgca 1120561 ggcattgcac ctgaagaaat tgattacatc aatgctcacg ggacaagcac gtattacaac 1120621 gacaaatacg aaacaatggc gattaagacc gtttttggcg agcatgcgca taaacttgcg 1120681 gtaagctcta caaaatcgat gacaggccac ctcttaggag cagccggcgg tattgaagcc 1120741 attttctcta tcctggccat taaagaaggc gtgattccgc cgacaatcaa tattcaaaca 1120801 cctgacgaag aatgtgattt ggattatgtg cctgatgaag cccgcagaca ggaacttaat 1120861 tatgttctca gcaactcatt aggattcggc ggacacaacg caacattaat ctttaaaaaa 1120921 tatcaatcat aatcaagcca aaccggctgc ccttaaaggg tagccggttt tttttgtgtg 1120981 cataggatta aaagaggagg cgatcacatg agtgtagaac aaacatatag ctggctcagg 1121041 aaggccggtt caatagatga tttggcgcat tacattatcc cgcttttttc aggtgcggag 1121101 aaaaagaact ggaagggcat tctggggcat cttcagcatc atgggatgtt taaaaacata 1121161 aaagagggta ttcagacggt ttccaagctg aaggaaaaag gtttttacgg acatatccaa 1121221 aaggaagaac agtacctcaa aaacaaatgg caaggtcctg atgtaccaat tgttacgctg 1121281 ccggttgatg aacgaaacag gagaatccgt ttagaattcg gatcaaaatc aggactcgcc 1121341 tttcaagaca aaatgttcct ttttctttcg tcagatttag attttgggtc ggtatctgcc 1121401 cttatgacgc atgagtatca tcacgtttgc cggttaggtc atctgacaaa agaggaaaag 1121461 gatgtcacat tacttgatac aatcatcatg gaagggctgg cggaatatgc tgtttatgag 1121521 aggttcggcc gaagtcaaac ggctgaatgg acgacttggt atacaccgga acagcttcag 1121581 gctttatatg aaaaaaagat tgcgccccat cgggatatca aacgggataa tcgattattt 1121641 ccccagctgt tattcggcaa aggatatcag ccaaaaatgc ttggatacgc agttggattc 1121701 aatattgtaa aaaaatattt aaccgccagc aaggcaagca ccgcagacgg gctgtccatt 1121761 cctgctgaga cctttttgga tgcaatgctt taaaaggata aaataatgga atttcattaa 1121821 taatattaca tttatcctaa aaaattcttg attttgcaaa atgattgtaa taatatacaa 1121881 ctataaaatt tttcgataat tcaatattat ttattatttc tgaataaagg gattgctttc 1121941 tcttgaaaac gtttgacaac aagagggggg aaaggggagc tagcatgagc acacttttag 1122001 aagtgaataa tttaaagact tattttttca ggaaaaagga gccgatccct gcggttgacg 1122061 gagtcgattt tcacatcagc aaaggcgaaa ccgtcgcgct tgtaggtgaa tcgggctccg 1122121 gaaaaagcat tacttcttta tcaattatgg gcctcgtcca aagctcaggc ggaaaaatca 1122181 tggacggctc tattaaactc gaagacaaag acctcacctc attcactgaa aacgattatt 1122241 gcaaaatccg cggtaacgaa gtatccatga tctttcagga accaatgacc tcccttaatc 1122301 cggtgttaac aatcggagaa caaattaccg aagtgctgat ttaccataaa aacatgaaga 1122361 aaaaagaagc ccgtcaacga gctgttgaac tcttgcagat ggtcggtttc tcccgggcgg 1122421 agcaaattat gaaggagtac ccgcatcggc tgtccggcgg tatgagacag agggtgatga 1122481 ttgccatcgc actgagctgt aatcctaaac tgctcattgc tgatgaacca acgacagcgc 1122541 tggacgtgac aatacaagcc caggtgctgg agctcatgaa agatctctgt cagaagttca 1122601 atacatcgat tcttctcatc acacacgact taggtgtcgt gtctgaagct gccgatagag 1122661 tgattgtcat gtactgcgga caagtcgtag aaaacgccac tgttgatgac ttatttttag 1122721 aaccgcttca tccgtataca gaaggcctgc ttacgtcaat tcctgttata gatggagaga 1122781 ttgataaatt aaatgcgatt aaaggcagtg tgcctacacc ggataatctg ccgccggggt 1122841 gccgttttgc cccaaggtgc ccgaaagcta tggataagtg ctggacaaat cagccttcgc 1122901 ttttgacaca caaaagcgga agaacggtga gatgcttttt atatgaggaa gagggtgccg 1122961 aacaatcatg acagcagcta atcaagaaac aatcttagag cttcgtgacg taaaaaaata 1123021 ctttccgatc cggtcaggcc tttttcaaag aaaagtcggt gatgtaaaag cggtggatgg 1123081 tgtttcattt tcgttaaaaa aaggagaaac actcggaatc gttggagagt cgggctgcgg 1123141 aaaatcgact gccggcagaa cgatgatcag actgtacaaa ccgacagagg gccaaattct 1123201 ttttaaaggg caggatattt ccaatctgtc agaggagaag ctgcggaaga gtgtccgcaa 1123261 aaatattcaa atggttttcc aagatccatt tgcttcgtta aacccgagaa agaccctgcg 1123321 ttccatcata aaggagccgt ttaatacgca caacatgtat accatgcgtg aacgaaacga 1123381 aaaagttgaa gagctgcttg caagagtagg gcttcacccg tcgtttgccg gccgttatcc 1123441 ccatgagttt tcaggcggcc agcgtcagcg gatcggcatt gccagagcac tcactttgaa 1123501 tccagagctg atcattgcag atgagccggt ttccgcactt gatgtatcca ttcaggccca 1123561 agtgattaac ttgatggagg aattacagga agaatttaat cttacgtatc tatttatctc 1123621 tcatgatctg agtgtcgtcc gccatatcag cgacagagtc ggagtaatgt atcttggcaa 1123681 aatgatggaa ctgaccggca agcatgagct ttatgacaac ccgcttcacc catataccca 1123741 agcgctttta tcctccgttc cggttacaag aaaaagaggt tctgtcaaac gtgaacgcat 1123801 tgtcctgaag ggagaactgc ctagtccggc caacccgcca aaaggctgcg tattccacac 1123861 aagatgtcct gttgcaaaac cgatatgcaa ggaacaaata ccagaattta aagaagctgc 1123921 tcccagccac tttgtggctt gtcaccttta tagctaatgt tgcccgcaca gctttgagag 1123981 ggggtatgca cactacataa acaacagcct agaagaacga acatttcaag agggggaata 1124041 tctaatgaaa agacggaaaa ccgcactgat gatgctaagt gtattgatgg ttctggccat 1124101 ctttttatca gcctgctcgg gatcaaaatc aagcaacagc agcgcgaaaa aatcagcagg 1124161 caaaccgcag caaggcgggg atttggttgt tggttcaatc ggagaaccca cactttttaa 1124221 ctctctgtat tctaccgatg acgcaagtac ggatattgaa aatatgctgt acagcttttt 1124281 aacgaaaacg gatgaaaaac taaatgtgaa attgtcactc gctgaaagca ttaaagaatt 1124341 agacggcggc cttgcatatg atgtgaaaat taaaaaaggc gttaagtttc atgacggaaa 1124401 agaactgact gcagacgacg tcgtatttac gtacagtgtc cctttaagca aagattacaa 1124461 gggagaacgc ggttcaacat atgaaatgct gaaatccgta gaaaaaaagg cgattacgaa 1124521 gtcttgttta agctgaaata taaagacggt aatttctaca acaatgcgtt agacagcaca 1124581 gctattctgc cgaaacatat tctcggtaat gttccgattg ctgatttaga agaaaatgag 1124641 tttaacagaa agaaaccaat cggttcagga ccatttaagt ttaaggaatg gaagcagggc 1124701 caatatatta agctcgaagc gaatgatgat tactttgaag gaagaccgta tttagatact 1124761 gtgacgtata aagtcattcc tgacgcaaat gctgccgttg ctcagctgca ggcaggcgat 1124821 attaatttct ttaatgtgcc cgccactgac tacaaaacgg ctgaaaaatt caacaaccta 1124881 aaaatcgtta ctgatttggc attaagttat gtgtacatcg ggtggaatga aaaaaatgaa 1124941 ttattcaagg ataaaaaggt tcgtcaagcg ctaacaaccg ctcttgaccg cgagtcaatc 1125001 gtcagccaag tattagatgg agacggcgag gtagcttaca ttccggaaag ccctttatct 1125061 tggaactatc ctaaagatat agatgttccg aaatttgagt acaacgagaa aaaagcgaaa 1125121 cagatgcttg cagaagccgg ctggaaagat acgaacggtg acggcattct ggataaagac 1125181 ggaaagaaat tctcgtttac ccttaaaacg aaccaaggaa acaaagtccg tgaagacatc 1125241 gctgtcgtcg ttcaggaaca gctgaaaaaa atcggcattg aagtgaaaac ccagatcgtt 1125301 gaatggagcg ctctcgttga acaaatgaat cctccgaatt gggattttga tgcaatggtc 1125361 atgggatgga gtttatccac attcccggat caatatgata ttttccattc aagccagatt 1125421 aaaaagggtt tgaactacgt ttggtataaa aatgccgaag cggataaact catgaaagat 1125481 gcaaaatcaa tcagtgacag aaagcagtat tcaaaagaat atgagcaaat ctatcaaaaa 1125541 attgcggaag atcagccgta tacgttcttg tattatccta acaaccatat ggcaatgccg 1125601 gaaaatcttg aaggatacaa atatcatccg aaacgtgatt tgtataatat tgaaaaatgg 1125661 tggcttgcaa aataaatttc ccttaaaggg gagggagagc gttttctccc tcttctgttt 1125721 ttaataagga aagtaaaggg ggacaagtat atggctgcat atattatcag aagaacctta 1125781 atgtctatcc cgattttatt gggaattacg attttatcat ttgttatcat gaaagccgcg 1125841 cccggagatc cgatgacatt aatgatggac ccgaaaatca gccaggctga cagagagcag 1125901 tttattgaaa aatacggtct gaatgatcct cagtacgttc aatatttaaa gtggctaggc 1125961 aacatggtgc agggtgattt cggaacgtct attgtcagaa aaggaacgcc tgtttcagaa 1126021 ttgattatgg caagactacc caatacgctc ctgctgatgc tggtttcaac gattttggct 1126081 cttatgattt ctattccgtt cggtgtcctg tcggcaaagc ggccgtattc aaaaatcgac 1126141 tatggcatta catttacctc gtttataggc ctggctattc caaacttttg gtttggatta 1126201 attttgatta tggtgttatc ggtaaatctc ggctggtttc caactggggg tgtcgagaca 1126261 ctgaataccg aattcaatat atttgaccgg attcatcatt taattctgcc tgcattcgtt 1126321 ctagctacag ctgacatggc cggactgacg agatacacga gatccaatat gcttgatgta 1126381 ttaaatcaag attatattcg cacagcgaga gcaaaaggat ttaaagagaa cagagtgcta 1126441 tttaaacatg gattgaggaa tgcattatta cccgtcatta caattttcgg tttgatgatt 1126501 ccttcattta tcggcggatc tgtcgttgtc gaacaaattt tcacttggcc gggattagga 1126561 aagctgtttg tcgattcagc attccagcgc gattatccgg ttatcatggc aatgactgtg 1126621 atctcggcgg ttcttgtcgt tgtcggaaac ctcattgcag acatccttta cgcgattgtt 1126681 gatccgcgga tcgaatatta aaaggaggga aacagagatg tcagagctgc aaacaactcc 1126741 ctcgccggag atcaggctga aagaaaatat ttcgaaaaag ccagaaacaa tgacaaagat 1126801 tttctgggaa aaattctcga aaaacaaact ggccatttta ggtgccgtta ttctttttat 1126861 cattattatg tctgctgttt tcgccccttt aattgcacct tatccccaag agcagcaaag 1126921 cctgcttgat aaatataagg cgccgggcct tgaacatctg atgggaacgg ataaatttgg 1126981 acgtgatatt ttcagccgga tcctatatgg agcgcgtgtc tctttattgg ttggatttgc 1127041 gtccgtagtc ggttcgattt tgatcggaac ggttttagga gcattagccg gatatttcag 1127101 aggaatagtg gatgctgtca ttatgcgtgt agttgacatt gtgttatcca ttcctgatat 1127161 tttcttgttg atcacgctgg tcaccatctt caagccgggt gtggacaaat tgattttaat 1127221 tttctgtctc acaggatgga ccacaacagc acgattagta aggggagaat tcttgtcgct 1127281 ccgttcaagg gaatatgttc ttgctgctaa aacaattgga acaaaaacgc acaaaattat 1127341 tttttctcat atcctgccca atgcgttagg gccgattatc gtgtcagcta cgctgaaagt 1127401 tgggtctgtt attctagctg aatcggcgct aagctacttg ggctttggaa tccagccgcc 1127461 aatcgctagc tgggggaaca tgcttcaaga cgcacagaat ttcacagtaa tgattcaagc 1127521 atggtggtac ccgttatttc ccgggctatt tattttaatg accgttttat gcttcaactt 1127581 tgtcggtgat ggcctgcggg atgcgcttga cccgaaaaat attaaataaa aatgaatatc 1127641 atatctgtta taaaatatca ccaaatcaga aaaaagcagg tctcctttag tcagaaaata 1127701 tacaaagaga tctgcttttt atgattctta cataaaccca gtgattccag atttcctcaa 1127761 tctctttgga ataatttctc tatcccttgc ctatactgtg gacaacagtt tttataaaag 1127821 tgaggggtta gagatgttat ttcttcatga tgtgtgggtc aattggtttg aaggggaaga 1127881 aaatggctac aatgtatgcc actttcacga atggcgcaag gaagatacgg ttgagctttt 1127941 ggatcaggtg ccgctgttaa gggtgccgtc agtactgttt cattacatag aaaacgattt 1128001 gtcagagctt ccgaaaggtt tgcttgaaga cgtacatcag aaatcgtaca ttcgaaaaaa 1128061 tcatgagcgg acaaagcttg agtattgttt tgtcgtaaca gacggaatcg gcattttagc 1128121 tgttgacacg atcggctaca cgatccctgt cagaaaaagc cgtctaatcc caagacagga 1128181 gcagctcgtt tatgaaatgg taaaagatgt agagcctgaa acatatgaat ttgagccaaa 1128241 gaagctggaa tcctccaagg aatatcacat cttatcatta gcaccagaac atgtcagagg 1128301 actgacaaga aaagaacggc aaattaagca gctgatgttt atggcgcttg accaattaaa 1128361 agggctgaaa aaccgagcgg aaattggcta ctggtacaca gagtggaatc cgcatatgta 1128421 tgaacaaatc aaaaggatga gctttgaaga gatttgggac atgctgtata acgaaacaat 1128481 tgaaggctgg tcggacaaac acctagcttt ttgcgaaaac ctaataaaag gacagccttt 1128541 tttcgaaaag ctttgggaaa tggaaaacga atcaaaggtc aactgaaaaa aaccgctctt 1128601 tgcaaagagc ggttttttga ttagcgtctt tttcttccaa gacccatggc attctccatt 1128661 tttttcagca ttttgtttgc tgtccgattc gctcgttccg cgccttcatc aagaatccgg 1128721 tctaattctt cagattctat cagctcgtaa tagcggtcct ggatcggttt taatgcgttc 1128781 actacgactt ctgccaaatc acctttaaac tcgccgtagc cttttccttc gtactttgct 1128841 tcaagctctt caattgtcgt attgccgagg attgaataaa ttgtaagaag gttggaaacg 1128901 cccggtttgt tttccttatc aaatttgaca atgccttcag aatccgttac tgcgcttttg 1128961 attttctttt caagctgctt cggctcatcc agcaatgtaa tataagcttt ctgattcgga 1129021 tcagatttgc tcattttctt cagcggatca ttcagagaca tgatacgtgc accgactttt 1129081 ggaattttca cttccggaat cgtaaagatg tcgttgtatt ttttgttgaa gcgttctgca 1129141 agattccgcg tcagctcaag gtgctgcttt tgatcctcgc cgacaggtac aagatccgtt 1129201 ccgtacagca gaatatcagc ggccatcagc ggcggatatg ttaacaggcc ggagacgaca 1129261 gcttcattgc ctttggattt gtccttaaat tgagtcatcc gctcaagctc gccgatatag 1129321 gcgacacact gcatcatcca tccggcctgc gcatgtgcgg ggacctctga ctgaataaac 1129381 aatgttgctt tttctggatc aagtccgaca gctaagtaaa gcgccgcgag attgcggata 1129441 ttctttctaa gctcaagccg gtcttgagga acagttatcg catgctgatc gacgatgcaa 1129501 aaatagctgt tataatcatg ctgcagttcg acaaactgct tcattgcacc gatatagttg 1129561 ccgagcgtca ctgagccgct tggctgaatg cctgaaaaaa tcgtttgttt catgaaaaca 1129621 tcaacctcat ttcttaaaac ataataaaaa aggctcattc ttcccctgta aaaaagggac 1129681 gaatgaaccg tggtaccacc ctgattattc cattaaaatg gaatcactct gacgtttgta 1129741 acggagactg ctccggctga gcctactttt ttccagttcg gtcagctgct ccaaagtcca 1129801 ttccacattg cccgttatct gctcccagca ccgcagactc tcttcaaaca ggtgaaacgt 1129861 gtactactct ttttcatagc aagcttttct tttgattgct tcattataaa tcaattataa 1129921 ccaattgtca tcatgaaaaa acattctttt ttccagtaaa attgtaataa tataaataac 1129981 acgagtgctg taaaatcctt aaatgataac tgctatcagc gtaaaaacag gcagatatta 1130041 tatgtaaaaa gcaatatggg cagaaaacac atgaaaaagt ttttaatcaa tttatgcttt 1130101 aaatggtaga aggatattat gttcatggaa gaaaaactaa cgaagtttaa atattttaaa 1130161 ttgataaaat aatattgcaa taaattattt gtttcattat aatgaacttg ttcactctat 1130221 tgttacagct tttttacaaa aataatcaga aaagacggaa cagaataaaa gttgtggaaa 1130281 ctcaggttca tttgtctgat atttctgagg atttagccgt aaggagctga aaattattat 1130341 tagggggttt gcgaatatga aaaaacgttg gtcgattgtc acgttgatgc tcattttcac 1130401 tctcgtgctg agcgcgtgcg gctttggcgg cagcggatca aacggtgaag ggaaaaagga 1130461 cagtaaagga aagacgacac ttaacattaa tattaaaact gagccgttct ccttacatcc 1130521 gggattggca aatgattcag tatcaggcgg tgttatccgt cagacttttg aaggattgac 1130581 acgtatcaat gcagatggtg agcctgaaga aggcatggct tctaaaattg aaacgagcaa 1130641 ggacggaaag acatatacat ttaccattcg tgatggtgtg aaatggtcta atggagaccc 1130701 tgtaactgca caagattttg aatatgcttg gaaatgggcg cttgacccta ataatgaatc 1130761 acaatacgct taccagctct actacataaa aggtgctgaa gcggcgaata ccggaaaagg 1130821 cagcctagac gatgtggcag taaaagctgt gaatgacaaa acgctgaagg ttgaattaaa 1130881 taacccgact ccatatttca ctgaattaac tgcgttctat acgtatatgc cgatcaataa 1130941 gaaaattgca gagaaaaata aaaagtggaa tacaaatgcc ggagatgatt atgtatcaaa 1131001 cgggccgttc aaaatgacgg catggaaaca cagcggctct attactctcg aaaaaaatga 1131061 ccagtattgg gataaagaca aagtcaaact gaagaaaatc gatatggtta tgatcaacaa 1131121 taacaatacg gaactaaaaa aattccaagc tggcgaactt gattgggccg gtatgccgct 1131181 cggacagctt ccgacagaat ccctgccgac cctgaaaaaa gacggttctt tacatgttga 1131241 gccgattgca ggagtgtatt ggtacaaatt caacactgaa gctaagccat tagacaacgt 1131301 caatatccgt aaagctttaa catattcgct tgaccgtcag tcgattgtta aaaacgttac 1131361 gcaaggagag caaatcccgg caatggctgc agtgccgcct acaatgaagg gatttgagga 1131421 taacaaagaa ggatacttca aagacaatga tgtcaaaaca gcaaaagaat accttgaaaa 1131481 aggcctaaaa gaaatgggct taagcaaggc atctgatttg ccaaaaatca aattgtctta 1131541 caacactgat gacgcacacg cgaaaatcgc tcaagcagta caagaaatgt ggaagaaaaa 1131601 tttaggcgtt gatgttgagc ttgataactc agagtggaat gtctatattg ataagctcca 1131661 cagccaagat tatcaaatcg gccgtatggg ctggctcggc gacttcaatg atcctatcaa 1131721 cttccttgaa ttgttccgcg acaaaaacgg aggaaataac gatacaggct gggaaaatcc 1131781 agaattcaaa aagcttctga atcagtcaca aactgaaaca gataaaacaa aacgtgcaga 1131841 gctgctgaaa aaagcagaag gtattttcat tgatgaaatg ccggttgccc caatctattt 1131901 ctatactgat acttgggtac aggatgaaaa cctaaaaggt gttatcatgc caggtactgg 1131961 tgaggtttat ttcagaaacg catattttaa ataaggctac gtctgaaaat aaaagacctc 1132021 aaggtatatg gggagaaaag ccccatatac ctttcttact gatggagtat aaaaatgtaa 1132081 aaaccatgga ggtgttcccc cttgctaaaa tatatcggaa gacgcttagt ctatatgatt 1132141 atcacactat ttgtgattgt aactgtgaca ttcttcttaa tgcaagcagc accgggcggg 1132201 ccattttcag gtgagaaaaa gcttccgcct gaaattgaag caaatttaaa tgcgcattat 1132261 ggcttggaca agccgctgtt tgtacaatat gtcagttatt tgaaatcagt tgcaatgtgg 1132321 gatttcggac cgtcatttaa atataaaggt cagagtgtta acgacctgat cagttcaggt 1132381 ttccccgttt catttactct tggagcagaa gctattctcc tcgctttagc gttaggtgta 1132441 ttgtttgggg tcattgcagc cctttaccat aataagtggc aggattatac cgtcgcgatt 1132501 ttaacgatat ttggtatttc ggttccgagc tttatcatgg cggctgttct gcaatatgtg 1132561 ttctccatga agcttgggct gtttccggtc gcggggtggg attcctgggc atacaccttt 1132621 ttgccttcca tcgcacttgc ttccatgccg atggcgttta ttgccagact ttcccgttca 1132681 agcatgatcg aagtgttaaa cagtgattat atccgcacag cgaaagcgaa agggctttcc 1132741 cgcccagcgg ttacagtgcg gcacgccatt cgaaacgcac ttttgccggt tgttacatat 1132801 atgggcccga tggccgcaca ggtcttaacg gggagcttca ttattgaaac catttttggg 1132861 attccggggc ttggtgcaca cttcgtcaac agtattacaa accgtgatta tacggtcatt 1132921 atgggtgtaa cggtgttctt cagtgtcatc ttgctattgt gtgtattaat cgtagatgtg 1132981 ttatacggca ttattgatcc aagaatcaag ctttccaaag caaagaaagg agcctaggcc 1133041 atgcagaaca ttccaaaaaa catgtttgaa ccagccgcag cgaatgccgg cgatgcagaa 1133101 aaaataagta aaaagagcct ttccctctgg aaagatgcga tgcttcgctt ccgcagcaat 1133161 aagcttgcaa tggtcgggct tatcattatc gtacttatta tccttatggc aatttttgcg 1133221 ccgatgttct caaggtatga ttattcaact actaatctct taaatgcgga taagccgcct 1133281 tcaaaagatc actggttcgg aacagatgat cttggacggg acattttcgt ccgtacatgg 1133341 gtaggggcgc gaatctcaat ctttatcggt gttgcagctg ctgttctcga tttgctgatc 1133401 ggcgtcattt gggggagcat ttcaggcttc cgcggaggaa gaacagatga aatcatgatg 1133461 cgtatcgctg atatcctttg ggcagttcct tcattattaa tggttatctt actgatggtt 1133521 gttcttccga aaggtctatt tacgattatt attgccatga cgattacagg ctggattaat 1133581 atggccagaa tcgtgcgcgg acaagtgctg cagctgaaga atcaggagta tgtgcttgct 1133641 tcacagacac tgggtgcaaa aacatcccgt cttctattta aacatatcgt gccaaacgca 1133701 atgggttcta ttttggtcac gatgacactg acagttccta ctgcgatttt tacagaagcc 1133761 tttttaagct atttgggact tggtgttccg gctccgctgg caagctgggg aacgatggct 1133821 tctgacggat tgcctgcatt gacctattat ccgtggcgtt tattcttccc tgccggattt 1133881 atctgcatta caatgtttgg ttttaacgtt gtcggcgacg gattaagaga cgcattggat 1133941 cctaagttac gtaaataagg gagtgatacg ggtgacacgc ctattagaag taaaagattt 1134001 agcaatttca tttaaaacat atggcggaga ggtccaggcg atccgcggag tgaatttcca 1134061 tctggataaa ggggagacgc tggccattgt tggagaatca ggttccggaa aaagtgtaac 1134121 ctctcaagcg attatgaagc tgattccaat gcctccgggt tatttcaaac gcggtgagat 1134181 cctgtttgaa ggaaaggatc tggtgccgct gtccgaaaaa gaaatgcaaa atgtccgggg 1134241 aaaagagatc ggcatgatat tccaagatcc gatgacctct ttaaatccaa cgatgaaggt 1134301 cggtaaacaa attacggaag tgctttttaa acacgaaaag atctcgaagg aagcggctaa 1134361 aaaacgcgcg gttgaactgc tggaattagt cggtatccca atgccggaaa agcgggtgaa 1134421 ccaatttccg catgaatttt caggcgggat gagacagagg gttgtcattg ccatggcgct 1134481 tgcagcgaat ccgaaacttc tgatcgccga tgagccgaca actgctcttg atgtaacgat 1134541 tcaagcgcaa attttggaat taatgaagga tttgcaaaag aaaattgaca cgtccatcat 1134601 ctttatcaca cacgatcttg gtgttgtggc taacgttgct gaccgggtcg ctgtcatgta 1134661 cgcgggacag attgtagaaa ctggtacggt agacgaaatc ttctacgacc cgagacatcc 1134721 gtacacttgg gggcttcttg catccatgcc gacactggaa agttcaggag aggaagagct 1134781 gactgcaatt ccgggcacgc cgcctgattt gacaaacccg ccaaaaggag atgcttttgc 1134841 cctgcggagc tcttacgcga tgaaaatcga ttttgaacag gagccgccaa tgtttaaggt 1134901 atccgatact cattatgtaa aatcgtggct gcttcatcct gacgcgccaa aggtagagcc 1134961 gcctgaagcg gtaaaagcga aaatgcgtaa actggcaaac acgtttgaaa aacctgtctt 1135021 agtgagagaa gttgaatgaa ttgactgaaa aactattaga aatcaaacat ttaaaacagc 1135081 actttgtcac gccgagggga acggttaagg ctgtagatga tttatcattt gatatctata 1135141 aaggtgaaac attagggctg gttggtgaat ctggctgcgg taaatcgaca acaggccgaa 1135201 gcattatcag gctgtacgaa gcaaccgatg gtgaggtgct gttcaacggc gaaaatgtgc 1135261 acgggagaaa atcgcggaaa aagctgctgg aattcaaccg caaaatgcag atgattttcc 1135321 aagaccccta tgcatccctg aatccgagaa tgacagttgc tgatattatt gctgaaggcc 1135381 ttgatattca taagctggca aaaacgaaaa aagagcggat gcagcgagtt catgaactat 1135441 tggaaacagt gggattgaac aaggaacacg cgaaccgcta tcctcatgaa ttttccggcg 1135501 gccagcgcca aagaatcggg attgccagag cgcttgctgt tgatccggaa ttcattatcg 1135561 cggatgagcc gatttccgct ttggatgtat ccattcaagc gcaggtcgtg aatttaatga 1135621 aagaactgca aaaagaaaaa gggctcacat acctgtttat tgcccacgat ttatcgatgg 1135681 tcaaatacat cagtgaccgc attggcgtca tgtatttcgg gaaactggtt gagcttgcgc 1135741 cggcagatga gctttatgaa aatccgcttc acccatatac aaaatcattg ctttctgcga 1135801 ttccgcttcc tgatccggac tatgagagaa atcgcgttcg ccagaaatat gatccgtctg 1135861 tccatcaatt aaaggatggg gaaacgatgg aattccgtga agtcaaaccg ggacattttg 1135921 tgatgtgcac ggaagccgaa tttaaagctt tttcatgatt catcaatcct tcaagagatt 1135981 tctcttgaag gatttttttg cgtcttcata gaaagtgaga atgataacat ttacaattag 1136041 aggaaaaagc ggaggcgaaa tacgattcaa tttctgcata acaaaaatgt ttttgcgcta 1136101 ttgctgtctc aatcttttca atctttagca ggagtcctcg tcacaatcgt tttaatggtc 1136161 cggatctatc aaatgactga ctccgttttt ttggcgggcc ttattttatc gttcatgtcg 1136221 tttgcgagta tagcagcaag cttttgcgtc tctccggtgc ttcgcattct cggttttaaa 1136281 aaggtgcttg cgggagcgaa tctgctgaga gcggtcttta ttatactgat ggcatacagc 1136341 gtcactcatc acggacaggc attcttttgg attacgctgc tgtttgtgtt ttgtttttcc 1136401 ttcgcgggcg ctttttttca gccggcaaga tttgcgctgc tgccgattat tgttccaaag 1136461 aagcaatatg taaaagcgaa tggtgtgatc tccctctcga atcaattgtt cttaacagca 1136521 ggctggggcc ttggaggcct tctgacgtac gccgtccctt ttgaactcgt tgtcggcgct 1136581 gccatttgcc tgtttgttct atcgggagct tccatcagtg tgctgcatgt aaatgaagaa 1136641 gaggctgcag gaactgctga aacagcatct gtcagaagta tatggaagga tttaatgatc 1136701 atccctattg taagagacat tactgtaatg gacatgttag aagctttggc gggttccgta 1136761 tggtcatctg ctattctcct cgcatttact gcggctgttt tgcatgaaac agaggtgtgg 1136821 tgggggatgt ttaacgcttc ctattttata ggcgcaattg tcggcagtgt gattgctatt 1136881 cgtttttctt ctttttttga gcggaatatg ggctatgcca ttatgttcag ctcgcttgta 1136941 atgtcggcgc tgaccctttt gttttcattt tctccagtcc catttttatg cgctctggct 1137001 tgtgctgcaa tggggccttt ttatcaggtg cgtgatattt gccaggaaac catgctgcag 1137061 gaagttattc ccgagcagaa acgaatcgga atcatggctg caaaaaatgc gattttgact 1137121 ccttggtcag gcgtcaccta ctccattatg gggctagtgg ctgatgctgc tggtgcgaaa 1137181 atagctttta tcgcggctgc tgcattatat atcatgacat ttctgattgc actggcgcag 1137241 ccccgtctgg ttcattacag gcgagaaaat cgagttcaat gagaaacact tcaaaatgaa 1137301 cggagcagct ggctccgttt tgctgaaaaa aaaatgaaac catggcggaa gttcgcacgt 1137361 ctttatagat gtaaggctgt ttaaacaaga agaaatgggg tatatctaaa agtatgaaga 1137421 caacgaactc ataaggagca aatcaatgaa ctggtatgaa aagcttagcg agtactttcc 1137481 aattgaagaa atgaaatcaa aagcgcatat ggaagctctt ctgaaagagc gaagcgatat 1137541 ttatcataaa gatgaaggca aacatcatat tttaatgttt gcggaattcg attcttttat 1137601 cttcgttgat tatctgtatg tgtctaagga tgcaagaggg caggggcttg gcggcaaatt 1137661 gatcgcgaag ctgaaaaaga aaaataagcc catattgctc gaggtggaac ctgtggatga 1137721 agatgatact gatacagaaa aacgcctgag gttttatcaa agagagcatt tcaagcatgc 1137781 tcagtcaatt gggtaccggc gccggtcatt ggctacgaat gaagtaaaca agatggagat 1137841 tctgtactgg tcaccaaaaa cagaatcaga agaagaaatt cttgaagcca tgaaacagac 1137901 atatgaaaac attcatactt ataaagatga gaaatggtac ggagaatcgt acgaaaaaac 1137961 ggatgaggtc ttggaaatca tcgatgaaga aaaacaaaaa aatattttcg atcagttaag 1138021 ctaattgaga ataagaacat atcatgaaca ttaaaaattt gctggattga cacatttttt 1138081 tcttaggata ctgttcacac ttactttttt atagtataat acctgtaaag attccttttt 1138141 tagagtaatt tcaatttaag aataaaatag atgttcatcc tactaattag aggagtgaag 1138201 atgaatggtt acactataca catcaccaag ctgtacttca tgcagaaagg cgagagcgtg 1138261 gctcgaggag cacgagattc catttgtaga aagaaacatt ttctctgaac ctttatcaat 1138321 tgatgaaata aaacaaattc ttcgaatgac tgaggacgga acagatgaaa tcatctcaac 1138381 ccgttcaaaa gtattccaaa aactgaatgt gaacgttgaa tctatgccgc tgcaagattt 1138441 gtaccgcttg atcaacgagc atccaggttt gcttcgccgt ccgatcatca ttgacgaaaa 1138501 acgtttgcag gtcggatata acgaagacga aatcagacgt ttcctgccaa gaaaagttcg 1138561 ctctttccaa ttaagagaag cacagcgttt ggcaaactaa tagatcgtat catcaaaaga 1138621 aggctgagtc atcagccttc ttttattttt caacctgctg gtaataaatg ctcgcaagga 1138681 tgacaaacgc aaccgtcaaa atggggagga gcgtttcgac tgtgccgtgc tgcgccataa 1138741 aaagcgacag ctttttgtct ctgacaatca tttctccgcc agtataagca agcagcccgc 1138801 ttcccgcgta aatcagaagc ggtattttct ctagtgcaat atggatgagt ttgctgcccc 1138861 aaataataac cggaaccgat acacacaatc ctataacaac gagagaaaac tcaccgtgtg 1138921 aagctcccgc aactgcgatg acgttgtcca gcgacataaa gagatctgca agcacaatcg 1138981 ttcgtatcgc tctccacagg gaggtgctgc ttttaatgtg tttcgtgtct tttttttcaa 1139041 tcagcagctg atatcctaaa tacagcagga aaattccgcc ggcgcactgc aagaacggaa 1139101 tgttcaaaag atatactgct gcacttgtta atccgattct catggcaacg gcaataaatg 1139161 ttccgagaat aatggcttgc tgtctttgct tgtccggcaa atgtctgctg gccatggcaa 1139221 taacaaccgc gttatctccg ccgaggatca ggtcaatccc aacaatgacg agcagagaaa 1139281 tcagatagtc atgctccatg aagcggcacc tcgctttcag tccttcgctt gtactactac 1139341 tatatgagac aggtcatatt ttatgatatc agccgcctga tctgccgttt tttaggcaaa 1139401 ggtgcatttt tatttctttt gtgactgttt tatcataaaa tagaaataca aaggaattca 1139461 cactggcctt ggttaaggtt aagatgtgga cggaatgggt aaagtgtagt aaagtacaat 1139521 taatcgggag cttagatgtc ccttcaacat cttatataga agggaaggtt ggcaaatgga 1139581 aattgaaaga attaacgagc atacagtaaa attttatatg tcttacggag atattgaaga 1139641 tcgcggtttt gacagagaag aaatttggta taaccgtgag cgcagtgaag aacttttctg 1139701 ggaagtcatg gatgaagttc atgaagaaga ggaattcgct gtggaaggcc cactttggat 1139761 tcaagttcag gcactggaca aaggattaga aatcatcgtc acaaaagccc agctttccaa 1139821 agacggacaa aagctcgaac tgccgattcc tgaggataaa aagcaagaac cagcatctga 1139881 ggatcttgac gccttgctgg atgatttcca gaaagaagag caagccgtca atcaggaaga 1139941 gaaggagcaa aagcttcaat ttgtcttgcg atttggcgat tttgaggatg ttatttctct 1140001 atctaaattg aacgttaacg gaagcaaaac gactttatat tcgtttgaga accgatatta 1140061 tttatatgta gatttttgca atatgactga tgaagaggtt gaaaatcagc taagcatcct 1140121 gctggagtac gcaactgaat cctcaatcag catacaccgt cttgaagagt acggcaagct 1140181 gattatttca gagcatgctc tagaaacgat aaaaaaacac tttgcatcat agcaaaccga 1140241 tttccttccg gaaatcggtt ttttttatgc acgaaaatgc cattttagag atgtgaaaaa 1140301 tcaaaaacat atagacaagc agaaaataca gcgaacagga gttgatcatc ttttccagaa 1140361 agtatacttc atctggaaag gagagatgac aattgtttag tgctgtgact gaagacggcc 1140421 aaatgtttca ccttctaggc gctcagcaaa accagaaatt aaagcggaga cggttcttct 1140481 gtccggtatg cgggggagag ctagctgtga agctcggact tcaaaaagcg ccgcattttg 1140541 cccataaaca gaacaagtcc tgcgccatag acatcgagcc ggaaagcgcc taccacttag 1140601 aaggaaaaag acagctgtat gtatggctga aaacgcaacg ggcttcacca atattggagc 1140661 cgtatataag gacaatcaac caaagaccgg acgtcatggc aagaatcaag gagcatatgc 1140721 ttgctgttga atatcaatgc gccactatcg ctccagatgt ctttcaaaag cggacagagg 1140781 gcttcaaaca agaaggaatc atcccgcagt ggattatggg atacagccgc ttaaaacgga 1140841 ctgcttcgtc cttttatcag ctttcaactt ttcattggca gtttatcaat gcaagtccat 1140901 acagagaact gatatgttat tgtcctgaaa ggcgttcttt tctccggctc agccacatca 1140961 ttccattcta cacaaaccat tcttattcct cagtccaaac gatccctatc catcgggcag 1141021 gtgcaggcga tctttttttc actgaaccga aaccctcaat tcaatattca ggctggacga 1141081 aagcgattca ccgttttcgc cataaacccc atcggtttaa ctcaaaggaa acaaatcgcc 1141141 ttaggctgct gttttatgag aaacgacaga cgcctttttc ttttctgccg actgaagtgt 1141201 ttgttcctgt tagaaaaggg gcagttttta agagtccggt ttttgtgtgg caggggtttc 1141261 tttatttgtt tatgacggat cttggaggta aacgtgcgcc aattcgtttt tcagccgttt 1141321 tgcagcagtg caaactgcac attcataata agaacattgc actcaggtcc gaatgcagcg 1141381 aagagtgtct ttcagaagcg gttaaacagt atattgattt tttgtgcaag aagggatttt 1141441 taagggagac tcagaaagaa gtatatgtgc tgaatcagcc tgcaggaggc atacactcca 1141501 tgcaggatct catagaaaga gaccgcagct gttttataga atgagtttgt cttatttggc 1141561 tcaccctaag acaaaggtgg tgggcaggct gtgaaaggca caaaaggaaa ggtttttcgt 1141621 gtttttactg cttttttggc attcgttctc ttcattactg catatgattt gacaaaaggc 1141681 agtgaaaaac cggaagatat tcacaacaca agtttattga gaaacagctg ttttttcaat 1141741 tggcttgaat caaagaagac gagggggatc accatggctg aggaaaaaaa agcaaaccaa 1141801 ctgcctgaca gaagtgaggt aaaggcagaa gacacatgga gacttgagga tatttttcct 1141861 agtgatgagg cctggaataa agaatttcaa gctgtaaaag aattaattcc gaatttatct 1141921 aagtataaag gaaagctggc agattcagct gatcatttat acgaggctct tacgtatcaa 1141981 gataaagtga tggagcggct aggtaggctg tacacatatg cgcatatgcg ctctgaccag 1142041 gatactggga actcctttta ccaggggctg aatgacaagg cgggaaacct gtatacacag 1142101 gccgcaagcg cgacagctta tttggttccg gagattttat ccatagaaga agacaaactg 1142161 cagcagttca ttcttgaaaa agaagaattg aagctgtact ctcatgcgat tgaggagatt 1142221 acaaaggaac gtccgcatgt gctgagcgag aaggaagagg cgctgcttgc tgaagcctcc 1142281 gaggtactgg ggtcatcttc aaatacattc agcgtgttaa ataacgcaga tataacgttt 1142341 ccatccatta aagacgaaga tgggaatgaa aaacagatca ctcacggcaa ctttattaat 1142401 ttcttggaaa gtgaaaaccg tgaagtccgc aaaaatgcgt ttgacgcagt gtataaaacg 1142461 tacggacaat ataaaaacac aatggccacg acgctaagcg gcactgtgaa aaaggacaac 1142521 ttctacgcga gagtgaaaaa gtacaagtcc gcgcgtgagg ctgcgctttc taacaacagt 1142581 attcctgagg aagtatacga taaccttgtt aagacgatta ataagcattt gccgctcctg 1142641 caccgctata ttgcgctaag aaagaaagtg cttgagcttg atgaagtgca tatctatgac 1142701 ctgtatacac cgcttgtgaa agatgctggg atgaaggtga catacgagga agccaaagat 1142761 tacatgctga aaggcctcgc acctttaggg gaagaatatg cctctatcct aaaagaagga 1142821 ctggaaaacc gctgggtgga cgtttacgaa aataaaggca aacgcaatgg ggcttattca 1142881 tcaggagctt acggcacgaa tccgtatatt ttgatgaact ggcataataa cgtcaataat 1142941 ctctttacgc tcgtgcacga gtttggacat tccgtacaca gctactatac gagaaagcac 1143001 cagccttatc catacggcaa ttacagcatc tttgtcgcgg aagttgcctc tacgacaaat 1143061 gaagcgctcc ttggcgaata tttgctgaac aatttagagg atgaaaaaca gcgcttatat 1143121 attctcaacc atatgcttga gggcttcagg ggaacggtct tcagacaaac gatgttcgct 1143181 gaatttgaac atctgattca tacaaaggcg caagaaggcg agccgcttac acctgagctt 1143241 ctgacaaatg tctattacga cctgaataaa aagtattttg gagacggcat ggtgattgat 1143301 aaggaaatcg gccttgaatg gtcgcgtatt ccgcacttct attacaatta ctatgtgtat 1143361 cagtatgcga caggttacag cgctgcccaa gcattaagca gccagatttt gaaggaagga 1143421 aagccggcgg ttgaccgtta tattgacttc ctgaaagcgg gaagctcaca atacccgatt 1143481 gatgtcctga aaaaagcggg tgttgatatg acgtctccag agccaatcga agccgcgtgc 1143541 aaaatgtttg aagaaaaact tgatgaaatg gaagagctgc tgatgaaagt caagcagtct 1143601 taaaaaagta agcctgtgcg gaaatgacgc acaggctttt ttaaaaccct ttaaaggttt 1143661 tccggtgatt caagcggtag agggtaaaca aaatagacag aaacagcaga ggagaggtaa 1143721 tataaagcgg cagcatatgc atcatgccta agatattcaa gcagaaaaaa acagcaatgc 1143781 acacaattga gatcaaagta gacatcatgg cggtcctcct cgtccttttt ccttataagg 1143841 atatgagtga atgcacttcg ttatgttttg tgacaaaaat atgaacatta agcatagagg 1143901 ttgtcaaaag tcgacatctt ttgttatcat aaggatgtga aattgatcac aaacaaacat 1143961 tacccctttg tttgaccgtg aaaaatttct cccatcccct ttgttgtcgt taagacatat 1144021 gaaaccgcgc ttatcccggc gcggtttctt tagtgctaaa aatggaacgt acgtttggtt 1144081 atggcataaa aaaacagcct caagcatatg cacgcctgcg gctatttttc acatgattga 1144141 tattcatcag aataagtgct gagagacttc caaaacattc cgtgtttggc ttccactttg 1144201 gcaacctttt tagcaaacgc cagttttttc atttcttttt ctacctcttc aaggctcagg 1144261 tcatatacaa gagcaatttc cttcgaggca acgaagcgga aatattcaat aaaacattct 1144321 aaaggcggtg tttccgacgg cttcggctcg tcgccaagca tctcaaataa aatttcttca 1144381 tatacatcat atgagtagct gccaggaact ttaagccctt catcctcatg ctgcgtatta 1144441 aaaaacgtca gtgtcggatt aacagaaaca tccatctcgg cagcaatttt catgtcacat 1144501 tgaagcgcct tgaccgcgct ttgagaatgc agatcttttt tgaattcttc aagatcgaga 1144561 cttgtatttt cagcaatctc caaaagcacg ttttcatccg taatattttt ctttgaaaca 1144621 aataggctct cctgcatatt tctgagaaat tgcatgccgg cttttcgtcc ttgcagttcg 1144681 gctgctttaa aagcgagagc agccatataa ggcgatgaaa gcggctgatc ctgttcgaac 1144741 cagacattgc cgtcacatga catgccagag cggctcgcga tcttttccca tgcttctgcg 1144801 agaagatgct tttttcgctt tttatttaaa gcggtaaggc ttgcggaagc gataatgcgt 1144861 aaggtgaaaa aacgtccgta tctgattttc agctttttga tgacgggctc taaggaccag 1144921 cattcaggac ataaagggtc tacaaacata taaatttcaa gcggtttttt tggatgaccg 1144981 tggcaatggg cgaagtatag ctcatgctga tagtttgtca agatgatcga tcctccgctt 1145041 ccgtttgatt caccatatgc cttgctgtca actccagccg gccaaacaaa aactcacgaa 1145101 tttcgccctc cagccctaca tggtccattg cgtccttcat acagctgagc cacgcatcag 1145161 ctctctcgtt tgtaattgga aagggaagat gccttgctct gagcatagga tggccgtgtt 1145221 cctcagtata aagaggaggc ccgcctaaat actgagttaa gaattgcttc tgtttcctgg 1145281 cggtttctgt caaatcgctt ggaaaaatcg gcttcagcaa aggatgagac gcgacacgct 1145341 cataaaaagt atcaacaagt tgcgatagaa gttcctctcc aatcgcttca taaggtgcgt 1145401 taaacgattg tcccatgttg actactcctt taaatatggc taataggaat cataaatcct 1145461 attgcaaaaa gtaattttct gtatttcatt gtttcatcta gatttatttt agcaacaagg 1145521 catcatttct acaaacaaac tgccttttat gcgtttgatg actcatttcg gctgacagcc 1145581 ggggtttgta tttcatatca tatcacataa aaatcaggaa tgcgtaagat ttcacttcgc 1145641 aaaaaaacca gagggaaaga gcacctctgg ttacgcgtaa taaactgaag ttattttttt 1145701 tacatagttt tgcgtttctt ggaaaggagg aatgcctccg tatcggtcaa cattccccgg 1145761 tccggcgttg taagccgcta atgccataga cacattgccg tcgtatttat ccagcatttg 1145821 ttttaaatat ttcgttccgc cctccacatt ttgctgcgga tcaagcggat tggaaacgcc 1145881 aagtgagctt gctgttgacg gcatcagctg catgaggccc atcgcacctg ctccgctgac 1145941 cgcttttgca ttaaagcctg attcctgttt gatgacggcg cggatcagtt tttcatcaac 1146001 gccatattta tcagcggctt ttttaatcgc actgtcaata gagaagtctc ccgaacggat 1146061 ctgatttgct tcatgtttgt ttgaagctga atctgcaaca gctgtttcag tgctttctgc 1146121 cgcttttgtg actgaacctg aattgctgct cgtatatgag ttaagcccat acgctgaaag 1146181 cagtgacggc gctgttgtat tcgcgctgtt cagcatgctg agcgggcttg gcgatgaaga 1146241 aggtgctgat tgctgagatg tcagaccgtt tgtatattgg ctgagcaaag aactgaaact 1146301 tgaaagcggg ctttccgtat tctgagtgtc cgagctgctg cgtgcattag atatggactg 1146361 taatgcctga agctgaagta atgctgccca attcgttaca ttcacgatgt cattccacct 1146421 tatatagact ttcgtttttc ttcataaaaa cgcagaattt tatttttggt ttcgcgctga 1146481 ggaatgctga attgctgaag cagcttttcg aaggcttgtc tgccctcatg ccaatccgcc 1146541 gcctcaaatt caatttcata gtcctcttta tttaaatatc ggctgtggtc taaaactatt 1146601 aagccttttt ctgtttcttt ttccgcacgg tttgttgcta aagatccaaa gtattgtatg 1146661 gcatccgtat cgatctgaag cttgtgcagc tggtccttca cagggccctc gggaactgaa 1146721 aatccagcga gatctgatac ctctgaaagc tgctggtgcg tttccagaag ccccacatca 1146781 gccggctcct ttaatgtaag gacatacttt ccgttttttc tgcggatacg aagcgcagca 1146841 tgtttttgtt tcagcgcgaa gctgtctgta tcaaaataat gattcttttg atctgtaaaa 1146901 tctttttctg tcagctggag tgccgatgct atgtttttga attcttgttt ggtcagcatg 1146961 tttttaaatt cgatttcaat ctcttggctc atgatgctct tcctttccgc cctgtaaatc 1147021 ttatttttac tattatctct ttagatgtta ggtttatcaa tatcgagctc gatatgataa 1147081 aatgaatctg tactttgttt aaaaaaggag agcattatgc aaaacagaat cgaaattttg 1147141 aatgcaacat tatcggatga tcagcttcgc cttgcctgtc agacagaagg aaacgaagcg 1147201 gaacgcaagc cgtcaggtca aatgcttgtt gattctgacc actttgcttt tgtatacata 1147261 cttgaattag ctgattcttt tgaatatgtc attataaagg aacatgtatg gccggaactg 1147321 aagcaggccc atgcacaaaa aataccggtt gttttagagg caggagacca aacaattgaa 1147381 ctggcaggcc tgcatgagga gctggaatat cttttagaaa atataaaaga taatgcaaac 1147441 tatggagaag aaatggaaga aaaagtgaaa cgcgtgtttt tatagaaact ggttcggaat 1147501 tgggggatgt atgatggatg acaaacaatg ggagcgtttt ttagtgccgt accgccaggc 1147561 tgtcgaagag ttgaaagtga agctcaaggg gatccgcaca ctatatgaat acgaggacga 1147621 ccattcaccg atcgaatttg tgaccggacg cgtcaagcct gtggcgagca tacttgaaaa 1147681 agcgagacgg aaaagcatac cgctgcatga aattgaaacc atgcaggaca ttgctggcct 1147741 tagaatcatg tgccaatttg tcgatgacat ccaaatcgta aaagagatgc tttttgccag 1147801 aaaagatttc accgttgtgg atcagaggga ttatattgcg gaacataaag agagcggata 1147861 ccgatcatac catcttgttg tgctgtaccc tttgcagacg gtatccggag aaaagcatgt 1147921 tctcgtagaa atacagatcc gtacactggc gatgaatttt tgggcgacca ttgaacattc 1147981 attgaattat aaatacagcg gaaacattcc tgaaaaagta aaactaaggc ttcagcgcgc 1148041 ttctgaagcg gcttcccggc ttgatgaaga gatgtcggag atcaggggtg aagtacagga 1148101 agctcaagct gccttttcaa gaaagaaaaa aggaagcgag caacaatagg taaaggggaa 1148161 gaagagcatg aaatttgccg tatcatcaaa aggagatcaa gtttctgata cgctgaaaag 1148221 caaaatacag gcgtatttat tggattttga tatggaactg gatgaaaatg aaccggaaat 1148281 cgttatttca gtcggaggcg acggaacgct tttgtatgct tttcacagat acagcgaccg 1148341 tttggacaaa acagcatttg tcggcgttca cacaggtcat ctgggttttt atgccgactg 1148401 ggttcctcat gaaattgaaa aacttgttct tgccatcgcg aaaacgccgt atcatacagt 1148461 cgaatatccg cttctcgaag tcattgtgac ctatcacgaa aacgagcggg aagaaagata 1148521 cttagctttg aatgaatgta cgattaaaag catcgaagga agccttgttg ctgatgtgga 1148581 aatcaaaggg cagctctttg aaaccttccg gggcgacggc ctctgcctgt caactccatc 1148641 aggcagcaca gcctacaata aggcgctggg cggagcgatt atccatccgt ctatcagggc 1148701 gatccagctt gcggaaatgg cttcaattaa taaccgcgtg ttccgtacgg tcgggtcacc 1148761 tctgcttctc ccatcccatc atgattgcat gattaagccg agaaacgaag ttgactttca 1148821 agtgacgatt gaccatttaa cccttctcca taaggatgta aagtcgatcc gctgccaagt 1148881 tgcatccgaa aaagtgcggt ttgcgagatt ccgtccgttt ccattttgga aaagagtcca 1148941 ggattcgttt attggaaaag gtgaatagaa agaggacata tcgtggagca tttttttatc 1149001 agaaagaaca ttacttccgc tgaggacggg atgactgtaa aagaatatgc cggtgaactg 1149061 ggaatttcga aacgtctgct gaccgatatt aagtttggcg ggggagacct gcagattaac 1149121 ggtgagcatg tgacggtcaa atacgttttg aaagagggag atcttcttat cgtgaagttt 1149181 cctgaggagc aggtgagcga gacgctgttg gcagagcctg ttccgctcga tatcctttat 1149241 gaggatgaac atgtgcttgt gataaacaag cagccgtatg tgtcatcaat cccttcgaga 1149301 gagcacccct ccggcagcat tgccaatgga attattgatc attatcaaac aaccggagtg 1149361 agggcgacag ttcatcttgt cacccggtta gaccgggata catcaggtat catgcttgtt 1149421 gccaagcatc gatttgccca ctccatttta tcgtctgcgc aaaaaaacgg ccttgtgaaa 1149481 cgccggtatg cggcagtggt tcacgggcgg atggcacaga tggagggaac agtcgatgct 1149541 ccgattggca gacatcctga cagtattatt gaacggacgg taacgccaga cggccagaag 1149601 gctgttactc atttttacgt cacatgtgca aatgatgaca tgacctcggt ggcattgcag 1149661 cttgagactg gacgaaccca tcaaattcgt gttcatatga gctatctcgg gcacccgttg 1149721 tgcggcgata cactgtacgg cggaacgaga caggaaattg gccggcaggc tctgcacagc 1149781 gagcatcttt cgtttatcca tccgctgaca caggagaaca tgaggtttca tgctccactg 1149841 cctcaggaca tgagcaaact gataaaagga gagaatcatt gattctctcc ttttttatat 1149901 ggggcgaaat cttgattcgt cgtaaggcag ggagcttgga acagagacgg tttctatttc 1149961 tggaaagcga aagcctgtca gttgatttcc gaacacgcag cctgtatcaa tgttgatggt 1150021 gcgattgacc ttccgaggct ctttcacagg tgtatgaccg tataccaccc aagcctttcc 1150081 gttataggct gccgcccaat cacgcctgat gggtctgccg tccggatatg tttcacccgt 1150141 cacgtcaccg taaagcacaa agtccttcac tctgcgggta tatttgccga tatcgtcagc 1150201 tcttatgcca gcatgggcga caactaattc tccattatgt aagatgtcgt aaagcggcgc 1150261 tgtttcgtac agcttcataa actgttcgct gactgatttt ttctcatctt tggaaagttc 1150321 ctcaagctct gccgctgttg tttcgagacc atgcatcact tttaccggat ttccttttaa 1150381 gtaacgatat aatttattgc aatggtttcc cgggacataa cgcacagcgc ctttttcgta 1150441 agcgccggct acaaatcgga tgacctctat cgatttgggc cctctgtcag ttaaatctcc 1150501 ggcaaaaaca agcaccctgc cttcttcatg gacaggtact ccatttttga ttgtatagcc 1150561 aagcttttgg attaatgcag tcatttcgtc atagcagcca tgaatatcgc tgatgatatc 1150621 gtaagccatg cggtctcctc cttaccgatt gttttattta ttatgaagca aagtgttgtg 1150681 agtcatcaca agcttttatg tgcaaattat agaagaagaa tcattttcta aacaggatta 1150741 agaccttatc actttatttt tcatcatcac ccttgttaaa atcgcgttat gttttttaaa 1150801 aatgaggttt tgttctctga gtgagaacta gcataaccct gacttaaaaa ggaggttctg 1150861 attatggcgc atacatctgt cgcatcttta gttgttgtac ttatcgttgc atttttgaca 1150921 cccatccttt tgcatcggtt taaactcagc atcccggttg ttgttgctga aatcattatg 1150981 gggctgataa ttgggaaaag cggccttaat ttagttgtgg agggtgacac ctggctccag 1151041 acactctcta tgctcggatt tatcttttta atgtttttaa gcgggcttga aattgatttt 1151101 tcgtcgtttg agaaaggaaa gaaaaagcag ttcctgccga atggcaagga agcgccgaat 1151161 acgtttgctg cggcatctgt tattttcgtc ggtattttta ttttatcatt gctcttgtcc 1151221 tatgggttcg tcttggccgg atttatccaa aatgcatttt tgatgaccct gattatttca 1151281 acgatttcat taggcgttgt cgttccaaca ttaaaagaag aacggatcat gaattcgaat 1151341 atcgggcaga ttattttgct tgttgctgtt attgctgatt tggccacgat gattcttctt 1151401 gctgtttttt cttctttata cggagaggac agcggaaaca tgtggctcct gatgattctg 1151461 tttgcggccg gagtggtgct ttactttttc ggccgggtct tcaaacatcg ctcttttgtt 1151521 caatccatgt caaaagggac gatccagatc gggacgcgtg ccatttttac gttaatcatt 1151581 gtactcgttg ccctgtctga atcacttggg gcggaaaata ttctcggcgc tttcttagcg 1151641 ggggttcttg tttccctgct ttcgccaaac aaagaacttg ttcagcagct ggactcattc 1151701 ggttatgggt tcttaatacc gattttcttc gtgatggtcg gtgtgaagct tgatatttgg 1151761 actcttttcc aggataaaac aattttaatc atgattccgc tcctgctgct tgcgctgtta 1151821 gtcagcaaaa tcattcctgt catgtactta aagaagtggt atgataaccg aaccattttc 1151881 gcgtctggtt tcctgctgac atcaacgctt tcgctcgtga ttgctgctgc aacaatcggc 1151941 cagcagcttc acgtgatcag tacaaatatg tcaggagcgc taattttagt agccgtcatt 1152001 gcaagtattt ttacgccgat ctgttttaaa aaattataca aacgggaaga gcagccggag 1152061 gagaaaaaga cgattacgtt cattggcgcc aatcaaatga ctttgcctgt cacactcgaa 1152121 ttgccagagg aagagtatga cgtgcgtgtt gtacacgtct accaagagaa tgcggaggaa 1152181 aagctgtcag aatcagtgtt tgctgttgaa acaatttctg actatgaaca cgagacgctt 1152241 gaatcactcg gcatttttga aacggatatc ctcgttgtgg cgacaggaaa tgaagatatg 1152301 aatgcagaca ttgcattact tgcaaaagat aaaggcacag aaagagtcat tgcaagcgta 1152361 ggatcaccgg agcatgaagc agctctgaag gagcagggaa tcagcatctt ttctattctg 1152421 ctgtcgacaa aaacgctgct tcgcgcactg attgaagcgc ctggcgtcat gaagctgctc 1152481 acgaaccaag agtcttcgct gtatcaaatt aatatggaga acagtaaata tgatggtgtc 1152541 attttacggg aattcccttt aacaggtgac gtcatctttg tcaggatctt cagaggtgtg 1152601 gacagcatcg ttcctcatgg ggatacgagg ctgaaacttg gagaccgttt aattgtcacc 1152661 ggatctcggg ggtacgtaac ggatcttaag aaaacattgg aaggataaat cttgaccaaa 1152721 taaggattcg tgttaatata gaggtgcaga acaattcaat atgtattcgt ttaaccacta 1152781 ggggtgtcct tcataagggc tgagataaaa gtgtgacttt tagaccctca taacttgaac 1152841 aggttcagac ctgcgtaggg aagtggagcg gtatttgtgt tattttacta tgccaattcc 1152901 aaaccacttt tccttgcggg aaagtggttt ttttattttc agagggggaa tgatttgtga 1152961 agttttcaga agaatgccgc agtgcagccg cagaatggtg ggaggggagc tttgtccatc 1153021 cgttcgttca aggaatcggt gacggaacgc ttccgattga ccgttttaaa tactacgtac 1153081 ttcaggattc ctattattta acgcattttg caaaggtgca gtcatttggt gccgcttatg 1153141 cgaaggatct ttatacaacg gggcggatgg caagccatgc ccaaggtaca tatgaggcgg 1153201 aaatggcgct tcatcgcgag tttgccgagc tgttggaaat cagcgaggaa gagcgtaagg 1153261 cgtttaagcc gtctcctacg gcgtactctt atacatccca tatgtaccgt tcggttttga 1153321 gcgggaattt cgcagaaatc ttagcggccc tgctgccatg ctattggctc tattacgagg 1153381 ttggtgagaa attgctgcat tgtgatccgg ggcatccaat ttatcagaag tggattggca 1153441 catatggcgg tgattggttt agacaacagg tcgaggagca aatcaaccgc tttgatgagc 1153501 tggcggaaaa cagcacggag gaagtgcgtg ccaagatgaa agagaatttt gtcatctcca 1153561 gctactatga atatcaattt tggggaatgg cctatcgaaa agaaggctgg tctgacagcg 1153621 ccataaaaga ggtggaggaa tgtggagctt cacgccataa cggatgacag caagccggta 1153681 gaagagctag cgagaatcat cattacgatt cagaatgaag ttgattttat tcacattcgg 1153741 gaacgctcaa aatcggcggc ggatattttg aaactgctcg atcttatttt tgaaggcggt 1153801 atagataaac gaaaattggt gatgaacggg cgcgtggata ttgcactttt ctctactatt 1153861 caccgcgtgc agctgccaag cggcagcttt tcaccgaagc agatcagagc cagatttcca 1153921 caccttcata tcgggaggtc ggtgcattca ctggaggaag cggttcaagc agaaaaggaa 1153981 gacgcggact acgtgctgtt cggccatgtg tttgaaacgg attgcaaaaa gggtcttgaa 1154041 ggcagaggag tatctttgct gtcagatatc aaacagcgga tttccatccc ggttatagcc 1154101 atcgggggga tgacgccgga caggttaaga gacgtaaaac aagcaggggc agacggcatt 1154161 gctgttatgt caggaatttt ctcttccgct gaacctttgg aagcagccag acgatattcc 1154221 cgcaagctaa aggagatgcg ctatgaaaag gcattatgaa gcagtggtga ttggaggcgg 1154281 aattatcggt tccgcaattg cttattattt ggcaaaggaa aacaaaaaca ccgcattgtt 1154341 tgaaagcgga acaatgggcg gcagaacgac aagtgccgct gccggaatgc tgggcgccca 1154401 tgccgaatgc gaggaacgtg acgcgttttt tgatttcgct atgcacagtc agcgtctgta 1154461 caaaggtctt ggagaagagc tttatgcatt atccggtgtg gatatcaggc agcataacgg 1154521 cggtatgttt aagcttgcat tttctgaaga agatgtgctg cagctgagac agatggacga 1154581 tttggactct gtcagctggt attcaaaaga agaggtgtta gaaaaagagc cgtatgcgtc 1154641 tggtgacatc tttggtgcat cttttattca ggatgatgtg catgtggagc cttattttgt 1154701 ttgcaaggca tatgtgaaag cagcaaaaat gcttggggcg gagatttttg agcatacgcc 1154761 cgtcctgcat gtcgaacgtg acggtgaagc cctgttcatc aagaccccta gcggagacgt 1154821 atgggctaat catgttgtcg ttgccagcgg ggtgtggagc ggaatgtttt ttaaacagct 1154881 tggactgaac aatgcttttc tccctgtaaa aggggagtgc ctgtccgttt ggaatgatga 1154941 tatcccgctg acaaaaacgc tttaccatga tcactgctat atcgtaccga gaaaaagcgg 1155001 aagactggtt gtcggcgcga caatgaagcc gggggactgg agtgaaacac cggatcttgg 1155061 cggattggaa tctgttatga aaaaagcaaa aacgatgctg ccggctatac agaatatgaa 1155121 ggtggatcgt ttttgggcgg gactccgtcc gggaacaaag gatggaaaac cgtacatcgg 1155181 cagacatcct gaggacagcc gtattttatt tgcggctggc catttcagaa acgggatcct 1155241 gcttgctccc gcaacgggcg ctttgatcag tgatctcatc atgaataaag aggtcaacca 1155301 agactggctg cacgcattcc gaattgatcg caaggaggcg gttcagatat gatgctacag 1155361 ctgaacggta aagacgtgaa gtggaaaaaa gacacaggta caattcaaga cctgctggcg 1155421 tcgtatcagc ttgaaaataa aatcgttatc gtggaaagaa ataaagaaat aatcgggaaa 1155481 gaacgctatc acgaggttga gctttgtgat cgtgatgtca ttgaaattgt ccattttgta 1155541 ggaggcggat gagcatgtta acaattggcg gaaaatcatt tcaatcaaga ttgctgctgg 1155601 gcacggggaa atacccatcg tttgacattc aaaaggaagc agtagctgtt tctgagtctg 1155661 atattttaac atttgctgta aggagaatga acatttttga agcatctcag ccgaattttc 1155721 tggaacagct tgatttatcc aaatatacgc ttttgccgaa tacagcgggc gccagtactg 1155781 ctgaagaagc ggttcggatt gcaaggctgg cgaaagcttc aggcctttgt gacatgatta 1155841 aagttgaagt catcggatgc agccgttcct tgctgcctga ccctgttgag acattaaaag 1155901 cgtctgaaca gcttcttgaa gaaggcttta ttgtgctccc gtacacgtcg gatgacgttg 1155961 tgctggcgag aaagctggaa gagctcggcg ttcatgccat catgccgggt gcatctccga 1156021 ttggatcagg acaaggaatc ttaaatcctt tgaatctgtc gtttattatt gaacaggcga 1156081 aagtaccggt catcgtggat gcgggaatcg gctcgcctaa agatgcggca tacgcaatgg 1156141 agcttggagc ggatggcgta ctgctcaata cggctgtatc tggcgctgac gatcccgtga 1156201 aaatggctcg tgccatgaag ctcgcagtgg aagcagggcg cctttcttat gaggcgggcc 1156261 gaatcccgct taagcaatac ggaacggcaa gcagtccggg agaaggtctt cctgtatgac 1156321 aggcaggtat tcaaggcagg agctgtttgc tccgatcggc ccatccggcc agaaaaaatt 1156381 gaaagaagcg cgcgccgtga ttatcggcgc cggcgcgctc ggaacagcca gtgcagaaat 1156441 gctggtgaga gcgggagtcg gctctgtgaa aattgccgac agagattatg ttgaatggag 1156501 caacctccag cgccagcagc tttatacaga agatgatgtc aaaaaagaaa tgccgaaagc 1156561 agccgctgcg gagcgccgtc tccgttcgat taacagcgat gttgatgtga ccggccttgt 1156621 catggatgtg acagcagaaa atatcttcga gctgattagg gatgcatcga ttattgtgga 1156681 tgcggctgat aattttgaaa cccgcctgat cgtaaatgat gctgcggtaa aggaagggat 1156741 tccttttctt tacggtgcct gtgtagggag ctacggtctt acctttaccg tggtgccggg 1156801 ttctactcct tgcctgcatt gcttgctcga tgcacttccg attggcggag caacatgtga 1156861 cacagctggc atcatcagtc cggctgtttt gcaggtagca gtctttcagg taacagatgc 1156921 actgaaactg ctgacgggag aggagtgcga gccggtgctg cgctcctttg atttgtggaa 1156981 aaacgagcgg tcagaagtga gagcggccag tctcaaacat gacgcatgcc caagctgcgg 1157041 cacaaaggat tttccgtttt tgtcttatga aaatcaaaca aaagcggctg tattgtgcgg 1157101 caggaacacg gtgcagatca gatcatctat tacgaaagaa gcggatcttg aagcgcttgc 1157161 cggtcagctg aggcaggccg ggcttgaagt agctgcgaac ccgtatttaa tttcctgccg 1157221 ctcggatgat atgaaaatgg tgctgttccg ggacggcaga gctttgatcc atggaacaaa 1157281 tgatattgcc cgggcaaaat ccatttatca taaatggatt gggtaataaa aggagtgtag 1157341 tgtaatgagt atatataaag cattgacaat cgccggatca gattcaggcg gcggcgcagg 1157401 gatacaggct gatattaaaa cctttcaaga gcttgatgta ttcggaatgt ctgcgattac 1157461 ggcggtaacc gctcaaaata cgcttggcgt tcacggggtg catccgctga ctgtagagac 1157521 gttgagacag caaattgacg ctgttgctga ggatttgaga ccggatgcag ttaagacggg 1157581 aatgctctgg aatgccgaca tgattgaaga agtggcaaga aaaattgacg agtacggatt 1157641 caatcgtgta attgttgatc cggttatgat cgcaaagggc ggggcatcct tgctgcgtga 1157701 tgagtcagtt gccaccttaa aggagttgct cattccaaga agctacgcga ttacgccgaa 1157761 tgtcccggaa gcagaaacgc tgacaggaat gacaatcagc tcgctggatg accggaaaaa 1157821 agcagcggag cagctcgtca agatgggtgc gcagcatgtc attatcaaag gcgggcacca 1157881 gcctgaggac aatcacatta ctgaccttct ttttgatggc agcatgttta tgcaaatcac 1157941 ccatccttat atcaatacga agcatacgca tggcacaggc tgcacctttg ctgcggcttt 1158001 aacggcccaa acggctaaag gagacagcat ccatcaggca tttgaggttg cggccaactt 1158061 tgtccgtgaa gcggtggaaa atacgctcgg catcggatcg ggacacgggc cgacaaacca 1158121 tttcgctttt aaacgaaaca gcttaaatac aagccgatga gatcaccagc tgatggtgat 1158181 ctcttttgcg tttgctacgg tatgcgcttt tcatctggac aaggttatga tatgatagga 1158241 attaagatca ggtactaata ctatgtcttt attaaatata ggaggcttta tacatatgaa 1158301 tttttcactt gaaggccgta acattgttgt gatgggggta gccaacaaac gcagcatcgc 1158361 ctggggcatt gcgcgttctt tacatgaagc gggtgcacgt ttgattttca catacgctgg 1158421 tgaacgcctg gagaaatccg ttcacgagct tgccggaaca ttagaccgca acgattccat 1158481 catcctccct tgcgatgtta caaacgacgc agaaatcgaa acttgcttcg caagcattaa 1158541 ggagcaggtc ggtgtaatcc acggtatcgc gcattgtatc gcgtttgcca acaaagaaga 1158601 gcttgtcggc gagtacttaa acacaaatcg tgacggcttc cttttggctc ataacatcag 1158661 ctcatattct ctgactgctg ttgtcaaagc ggcacgtccg atgatgactg aaggcggaag 1158721 cattgtcact ttgacgtacc ttggcggaga gcttgtgatg ccaaactaca acgtcatggg 1158781 tgtagcaaaa gcttctcttg atgcaagtgt gaaatattta gctgctgact taggaaaaga 1158841 aaatatccgc gtcaacagca tttctgccgg cccgatcaga acattatctg ctaaaggcat 1158901 cagcgatttc aactctatct taaaagacat cgaagagcgt gcaccgcttc gccgcacgac 1158961 aacacctgaa gaagtgggcg atacagctgc gttcttgttc agcgatatgt cccgcgggat 1159021 tacaggtgaa aatcttcacg ttgattctgg tttccatatc actgcccgct aagcaggctg 1159081 ttaatgatgc aagggctgtc ttgctttctg tagcagggga tacaaaaatc ttgagcggtt 1159141 ggctgttttg ccgcgcctgt tagcagggca agacaaatat aaatgctgtt tcgcccgggt 1159201 catggctaca tataaaaggc gtctttcctc ctcaagagcg gcctcgtctc cttttcttgc 1159261 cgtttctaat gagaaatcgt gcggaatcga gccatctaca gtgcctaaca cgtagactgt 1159321 tttgaattca aggccttttg accggtgaat ggtcatcagc tgaacgccat gttcatccgt 1159381 tctgtttttc tcagcggccc tcatatggtc tacgtgggca agaaagtcag gaatcgtttt 1159441 gaacttcttg gcgacaacct tgatgtcgcg caggtcatca gagccttttt ccagcttgtt 1159501 gccctcattg ccccgctttt ttaaatactc ggagaagccc atttttcctt ctgcaaaggt 1159561 gatggcttct acgggtttca ttgtgcggag gcttgcaaaa aacggtacga ttttcttgat 1159621 tttgtccagc tggaatggct tcagatcagg caatttggcc agcgctttga tcatggtaca 1159681 gtcctctgta atcgagagcg ccttcagcgt attcaaagcg gactgtttta aaaacaaggc 1159741 gggaagcaag tgtttaatcg cctcggtgtc atcctcattt tggctggcgt acaagtaggc 1159801 gagaatctgg cggacgatcc gtctgctgta aaacgattgg acgccgcggt cagctgtata 1159861 cggaattgac gattgatgaa gcctttcata tatagcacgg cctccgctgt ttgtgcggta 1159921 aagaaccgca aagtcttctg gactggctcc attttgaatt ttttctttga tatcggaaac 1159981 gaccattgtg gcttcttcct cttcatcata aggataaaac agcacaggga cctgaatgtc 1160041 atcgcgggcc gcttcaagcg ttttggcata tctgtttttg ttctttttca caacgatatc 1160101 agcactagag acgatcgggt gcgtagacct gtagttcgca gttaaataga tcgtcttcgc 1160161 tcccggataa tccttttgaa aatcaagaat gaaagacgga ttgcttccgc gaaacgcgta 1160221 gatggactgg tcatcgtctc cgacacagca caggttttgc tccgggctgg cgagcatttg 1160281 catgattttg tattgaaccg gattaatgtc ctgaaactca tcaattaaga tatacgtaaa 1160341 ccgagattga tattgttcca gaaggtcagg ccgctcgata aacaattcat agcaggctga 1160401 agccatgtca tcaaaatcaa attggctgtg ttcttttttc tggcgttcat aatgttcata 1160461 taaacgataa acttgttttt cccactcatc ttttagaggg atgcgttcat ttgggacata 1160521 agtgtttttc caaaaaccga tctgctgcag ggcttggtca actggggatt ctttctcatc 1160581 gatgccttct tcatagagtg cttttttgat atattgttcc cgctgccact ccattttcag 1160641 cagatgctca ccgttccatt tagcagaatt agagtgatac aagatcttat aaaacagact 1160701 gtggaatgtt cctgtcacaa ttcttctgac ttttgccggc tgtaatccgt actggttcgc 1160761 catacgctct ttcatttcag cgacagcttt tgttgtaaag gtgacaagca gcatattttc 1160821 aggcggtatg cctaagtgtt cgatcatgtg ggcggcacgg gctgtcagta cccgtgtttt 1160881 tccgctcccc gcacctgcaa gcacgaggag cgggccctct gtttccgtga cagctttcag 1160941 ctgatccgtg tttaaaccga cagacggaaa aaggctcgta tcgggttcta ttgtttttgg 1161001 cacaaatggt gttcctggtt taatgcttct aggacggtgc cattctgtaa cagctgggga 1161061 cgggtcagcg gcgatcgctt ttcccttggg taaacgaatg acaccagatt cctgatcatc 1161121 ttcttttttc ccctctttag agggcttcgg ttcgcacgcc tcctcacatg ccggaaaatc 1161181 gcctggctgg cgatggataa actctggcgg atcggcgatg ttaagccgta acaaaacggg 1161241 ctttccgcaa tgagaacaaa ataaatgtcc ttttattccc tcttcaaaga ggaattgata 1161301 atgttctctc gaatatgtat gtaaatgtat gattctatca ttcagtcggg cgcatttcaa 1161361 aaaggggtcc tcccaatcaa aaggtgttca ttacagacaa tgactatcat atcaaaagaa 1161421 atgtgtttca aaaagtaagt ttaagggaaa agagacagca gaggggtggg tattgtatga 1161481 tatatgcagg tcaaattcag aaccagcaat acgctcaata tgctaataga acgattggac 1161541 ataagcagga ttatgccgga accgaaaaaa tcagctatgt cccgtttcag cgggtataca 1161601 aagaactgga aaagcagcag gagaatcaaa cggcagctga aagaaaagta aacgagatga 1161661 aacgtaagcg ctctctttat aagagattgc gagaaaaagg aatggggaca tatattaatc 1161721 gatatgtata aaaaaccgtt cataccagag aacggttttt ttatatgcag taaaaatccg 1161781 gatctcaaaa gatccggatg cgttcagtcc ttcatcattt gtaagtgcgg aatgccggca 1161841 tcgaggaatt ctttttcaga aagcacgcga tacccgtgtt tcttgtaaaa cggcacagcc 1161901 tgtgtttgcg cgtttaaaat gaaaccggaa gcgcctccgt ctgccgcggc tttttcgagc 1161961 gctttcataa tgatgccgcc gacaccggct gagcggtggc ttttcagtac gcaaatccgc 1162021 tctaacttgc cgtagccgtc cttcatgcgc catcttccgg caccgacagg cttttcaccg 1162081 tcatacacga cgatatgctc tgactcattt tcaagttcgt caatttcttc ttcagcaggc 1162141 acgttttgtt ctttgacaaa gacttcttct cttacataga atgcatcttt cagttgttct 1162201 tcattttttg cgataactgc tttcaaacat tattctcctc tgcctagcaa gaaggtttca 1162261 tatactgtcc acgatccgtt ttccaactgg tagagcaagt ggaaacggtc aacgatttct 1162321 tcatgcgaca cttcctgcat ttttaattgt cccagcacat ctgaatgctc atcgtcggaa 1162381 agattttggc cgaccgtcac atgcggaacg aaattatatt cctgttctcc tgccaacaca 1162441 ccggtgtata gcttttcatt gagtgttttt aactcttccg tcggttctgc tttgatgtaa 1162501 atgacattat tgacaggcgc aaatgagctg tattttgtca ttttgagaac gagtgggtgg 1162561 gactcttttg cgatgtttct taaatgtgat acgagctgat ccgctttctc ctccgcgcat 1162621 tcaaaggatg ctctcagcgt caaatgaggc gggattagag agtagcttgg gtcatagcgc 1162681 tttctgtaag agtttgcaag gtcttggagc ttttttgatg gaaataaaac gattccgtat 1162741 ttcatattat gtccctcctg gaaataaagt atgatagagt gttaaagcat ttttttcagc 1162801 gccggggtga tgagcggctg ccagtatgtc catttgtggt ctccgtcaaa tggctcgaaa 1162861 tcataatcgg aaagcttttt ctccagcagc tgtttcagct cccggttcgg ttctgtaaag 1162921 tccagaatgt tcccgtctgt cgtgtggacg tcagtttctt ttgttccgat ttggtgataa 1162981 atagagaggt gtttgatatc gtctgactgt tttacggctt ctagtacgtg tttgtcaaca 1163041 tagggagact gcatgatgat gttgccaaac atattcggat aatcaagcgc tgtcataagt 1163101 gacacggttg ctccgagcga atcaccgatc agcgttcggc cgtaaccgat ctgataggtt 1163161 ggatactcat catctgcaaa aggaacgagc tcatgggcga tgaaccgttt ataagccgaa 1163221 aattttgaac cctccggatg ataagtgttt ctgcgctctt ttacatcctt atagggaaca 1163281 ccgataataa tgctccggtc tatttcgcgt ttcgacagca attcctcaac ctgtctgccg 1163341 attctcccca gcctgaaata atcgtggccg tcctgcgcga taatgacatg gtatttataa 1163401 agcggggagt agttggacgg cagataaaca agcaaggtca tttcctcgtt aagctctttt 1163461 gaaaagaatt tcttttcttg cactgtgccg tttttcggtg ccataaaaac attcctccag 1163521 gacatcacta tactttcttg cattttcaat tattgtacca tgaattatta gaaatttctc 1163581 tctttaaacg gttcggcaca cgaagaaaaa agtgttgaaa taaactgtga attgcgctaa 1163641 tataaaacaa tcagaaaatt gaaatcgata tttcttatcg tgagaggtgg agggactggc 1163701 ccttagaaac ctcagcaacc ggcttgtttt gcatttgcaa agcgccaagg tgctaaatcc 1163761 agcaagcgtt ttttatgctt ggaagataag aagaagcgtt aaaccccttc ttcttatgaa 1163821 gaaggggttt ttattttgaa aagggaaggt gtcagctata tgtcacagca cgttgaaacg 1163881 aaattagctc aaattgggaa ccgtagcgat gaagtcacgg gaacagtgag tgctcctatc 1163941 tatttatcaa cagcataccg ccacagaggg atcggagaat ctaccggatt tgattatgtc 1164001 cgcacaaaaa atccgacacg ccagcttgtt gaggacgcga tcgctaactt agaaaacggc 1164061 gcgagagggc ttgcctttag ttcgggaatg gctgctatcc aaacgattat ggcgctgttt 1164121 aaaagcggag atgaactgat cgtttcatcg gacctatatg gcggcacgta ccgtttattt 1164181 gaaaatgaat ggaaaaaata cggattgact tttcattatg atgatttcag cgatgaggac 1164241 tgtttacgct ctaagattac gccgaataca aaagcggtgt ttgtggaaac gccgacaaac 1164301 cccctcatgc aggaggcgga cattgaacat attgcccgga ttacaaagga gcacggtctt 1164361 ctgctgatcg tagataatac attttataca ccggtcttgc agcggccgct tgagctggga 1164421 gctgacattg tcattcacag cgcaaccaag tatttaggcg ggcataacga tctgcttgct 1164481 ggacttgtcg tggtgaagga tgagcggctc ggagaggaaa tgtttcagca tcaaaatgca 1164541 atcggcgccg tcctgccgcc atttgattcg tggcttctga tgagaggaat gaagacgctg 1164601 agcctcagaa tgcgccagca tcaggcaaac gcgcaggagc ttgcggcgtt tttagaagag 1164661 caggaagaaa tttcggatgt gctgtatccc ggaaaaggcg gcatgctgtc cttccgtctg 1164721 caaaaagaag aatgggtcaa tccgttttta aaagcactga agaccatttg ttttgcagaa 1164781 agcctcggcg gggtggaaag ctttattaca taccctgcga cccagacgca catggatatt 1164841 cctgaagaga tccgcatcgc aaacggggtg tgcaatcggt tgctgcgctt ttctgtcggt 1164901 attgaacatg cggaagattt aaaagaggat ctaaaacagg cattatgtca ggtcaaagag 1164961 ggagctgttt catttgagta aacacaattg gacgctggaa acccagctcg tgcacaatcc 1165021 atttaaaaca gacggcggaa ccggggcagt cagtgtaccg attcagcacg cctcgacttt 1165081 tcaccaatct tcatttgaag agttcggggc atatgattac agccgctctg gcacgccgac 1165141 aagaacagct ctcgaagaaa caattgccgc actggaaggc ggaacaagag gatttgcttt 1165201 cagttcaggc atggctgcca tctcaacagc atttttactg ctgtcacagg gtgatcacgt 1165261 tcttgtgaca gaagatgtat acggcggaac cttccgtatg gtgacagagg tgctgacccg 1165321 gtttggcatt gagcatacgt ttgtcgacat gacggatcgt aatgaagtgg cgcggagcat 1165381 caagccgaac acaaaggtca tttatatgga gacgccatca aatccgacac ttgggattac 1165441 ggatattaaa gcagttgttc agcttgcaaa agaaaacggc tgcctgacct ttctggacaa 1165501 tacattcatg acgccggcac tgcagcgtcc gcttgatctc ggcgtggata ttgtacttca 1165561 cagcgcgaca aaattcttaa gcggacacag cgatgtgctc tcaggtttgg ctgctgtcaa 1165621 agatgaagag cttgggaagc agctgtataa gctacaaaac gcgttcggcg ccgtccttgg 1165681 cgtgcaagat tgctggcttg tcctgcgcgg attaaaaaca ttgcaggtcc gtttagagaa 1165741 agcgagtcaa acagctcagc ggcttgcgga atttttccag aagcacccgg cggtcaagcg 1165801 cgtgtattat ccgggactgg ctgatcatcc cggcgctgaa acccataaaa gccagtcaac 1165861 gggagcgggc gccgtgctat cttttgagct tgaaagcaaa gaggccgtta agaagttagt 1165921 cgagaatgtg tcactcccag tcttcgctgt cagccttggc gccgtggaat cgattttgtc 1165981 ctatccggca acgatgtctc atgcggcaat gcctaaggaa gagcgtgaaa aacgcggtat 1166041 cactgatggc ctgctccgtc tgagtgtcgg cgtcgaacat gcagacgatt tagaacacga 1166101 tttcgaacaa gcgctgaaag aaattgctcc agtttcggtt cgttaaaaaa gaagccgggg 1166161 atagtccggc ttcttttatt attgttcgtc atcaggattc agaatcgcga ggacttgatg 1166221 atcctcccaa acgccattaa tttttacatt ttttcgggcg atgccttctt tatgaaatcc 1166281 cgctttttct aaaacacgca tggacccgag attacggggc atcacaccgg cttcaatccg 1166341 atgcagtttc aattcgtgga acgcataatc aacaaccaat ctgactgcct ctgtcataat 1166401 gccctttcca ttatgggctt tgtctaaaaa atacccgatg aacgcagttt gcagcgcgcc 1166461 acggatgatt tgaaagagcg aaaccgtccc gattaatcta tcgtctgacg ctgtaaagat 1166521 gccaaaatga tattcttcat ctttctcaag tctttcctga tactcggtta ttcgttttct 1166581 ttgcccctca accgtatagt aatcgtctgc gcgtatcata gaaaactgtt cgaaaaaatc 1166641 tcgattttcg ctttgcagcc ccagattttc ttcggcatcc gttacttcta aaggtctaac 1166701 ataaatggtt tttcctttta acatatagtg atctctccgt tctcatgtca gcattcctct 1166761 tacattattc tcagggaaat gcaaatatcc tttttataag aaggaagaaa accaatttcc 1166821 cataaaagtg ccaacatagt tgccgattaa gtagccgagc gtaccgacaa gcatgatcgg 1166881 ggcgacaagc tcccgccatc ccttggcaat tgccatcgca gccgcagtcg tcggtccccc 1166941 gacagtagcg ttgacggcga gcagaatttc ttcaagccgc acacggaaca attttccggc 1167001 agctaaggaa accgctaaat tgctaatcgc aatgataaac acgaataata gaataagagg 1167061 cgcattcgtg acgattaagc ggagatctgc aggaatgccg atcaccacaa aaaacaaata 1167121 aatcaaaaag gttccaagct cctgagatcc attgagcctt tcaaaaaaac gcgggaaaag 1167181 aaaaatgata agaacagtta aagacgtaag aaccaggtac tgatcgccaa gcgtaccggt 1167241 cagcagggga tgagaaaaaa tgcttttaaa ataaccggaa accttcatac taaccgcaac 1167301 aagcgcgaaa gcggcaccgg cattaaaagc gatatccttt aaggaaatat ccttccgttt 1167361 ccaatagctt tcagcactgt ttccgctgtt tccatcggct tttaccttct cttcaaacgg 1167421 catggcataa tgccgctgaa accatttgag tgcaggaatg ctgattaaaa taaaaaacaa 1167481 aagcgccatc ataaaattat cagccacaac ggtagccgac acatattcac caggcgtctc 1167541 aaattttgcc gccatcgccg caaagttgac cccgccgccg atataagagg cgctgatcat 1167601 cccaccgatt ttatctaagt aaggaatatg ctgtttgagt agaaaaaaag ccaggatact 1167661 gccaagcact gttccaacgg agctaatcag aaaaataaac agcaaacgcc tgctttcctt 1167721 aaaaatttgc ctaacattga tctgaaacaa taaaagtggt atcgccagcg gtaccacata 1167781 agaccacaca gtgtcataca cgggcgactc aacaggaagc actcctacat ttgtaaacac 1167841 catagcacct gcaagggcga taatagcgcc cgacacagca gacgcccact taaagcgctg 1167901 ctccagcccg atgctcactg ccgcccacac cgcaataaac ccccataata cccatacatc 1167961 atcagaagaa atcaaagaat gcaaaacccc atcacctcta ttgttagaaa attaagacat 1168021 attataatag ccggggaacg gaacagcaag tccaaaaaaa gtttttctaa aaaagcagtt 1168081 gacgaataga aggtaaggtt atataataga acttgtcaga aagataacaa catacccagc 1168141 aacacataca tatcatgatt ccgtagctca gctgggagag cgctaccttg acagggtaga 1168201 ggtcgctggt tcgagcccag tcggaatcat agcttaaacc cttgcgcagc aagggttttt 1168261 tactttgcgt taataaagcc ggttcgtcaa attcgtgagt tgttggcgaa ctgttggcga 1168321 aattcattga ccgcagtcca aaaactacct ccaaacttac ttgattagtt caatagtaac 1168381 aaacggaaga tcggatttct gttaaatctt cattgagaat agccagtcca agaccgtcac 1168441 ttcagccatg catcttttaa atgaaatttt gtactgaaaa catcaattgt atttttaaat 1168501 tctgctctag aatcagcccc tttataataa tcttgataaa ttgcttgggg tgatactgat 1168561 tcgtgatttg tgctatggtt tgcaaggctt gtagcaaaag caggagcaac agtaacgagt 1168621 aaagcaaggg ataatgcaaa accagttaaa gctttttcaa tttcatttta agcacttctt 1168681 tttttaaaat acaactttat tattaaatgg aatacaaaaa catccaaggt gtttttttgt 1168741 tagtaagttg agttaggggg attggatggc acttagaata ttgtttctgc tgatgggatg 1168801 ttgattctgg atatatttcc aacacgatta caggccggac atgaaagcga accttgcttt 1168861 gatcggggca atcatttcat ttacggctgc ggtttacttt aaagatattg atgtattgag 1168921 agaagaggga aaacaaatga acggaatttc tgagcgttgg aacacgttta aattacaaaa 1168981 atcccctgaa ccactctaga tcaggggatt gctttcccaa cagcttatta agtagcggaa 1169041 ggcatgatca acgatttagt atcaatttat taattgcgaa tactagaaac ataccgtttt 1169101 ccgccttcct tagaagtaac atattctcga ggaacattaa gtctattggt agaatgataa 1169161 cttacataaa gtttcatatt tgctcggctc gttacgatag ccgtatgatc catccaacca 1169221 tcagcatagc gaagacctat tttattatgg taatcatagt gatatacatc tccaagcttt 1169281 acatttgaat atgtatcaga aacagtcttc atttttattc cgccagcttt taaaatgtat 1169341 gatctaaagg ctcctgcatt aacccaagca tctgtatagg gtttccattc tttaaagtac 1169401 ggcattcttc cagctcttaa tgcttgggaa acaaagttag tacaatcttt gtctttataa 1169461 tatttatagt ttttatttgg ttttaaggca tatttttctg catatttcat tgcagcgtaa 1169521 ccactatatc ctttaacaga tgttgcagtc acagttagtt gattagagtt agcagcattg 1169581 aagttcatac ttactggttt atcttcactt ttcacttctt ctttatcatc atttttcact 1169641 tcttgcttat atttttttaa aaattcatct aatttaacat ccgaagaata ttcttcatca 1169701 ttttcatatt gtagagttga agaagaatta tttaattgtg ttacatttag ttgcttagaa 1169761 gaattactca atggtattac atttagttga ttagaagaat ttttaacttg agagaaactt 1169821 agattagaag tatttgttga ttgagaactt tgtttattag aagttgtttt gggaatttca 1169881 agtttaatat tatcgcccag agatgttgtt actttttcaa caccaaaaac aaagtttcga 1169941 gtaatataag cttcaacaat tagcttattg tttttttcag aagtcttaac atcgtctata 1170001 tcgtatgtaa actcgtggaa tttttgtttg tccactttac ttaacgcaga atacagtaag 1170061 actccttcgt cggaatcagt caatttagac tctttaggat gcgctaaagg agtgttgtgt 1170121 tcaaaatcat atttttgttg ttctaacata tccttaactt tttcgtaacc aatctcgttg 1170181 gtaattgaaa cattttcttt agtctcttta ttagtagtgg ctgcaaaaac ttcatttgtt 1170241 gacactaatg gtgacaatga tagacataaa actagtgaag caagtaattc ttttttcata 1170301 cgaaacctcc aataaaatct aaatataagt aatatttatc atttacacca attgaaatat 1170361 ggcataaaat acatgtaata atataacata aaaataaata cataaaaagg tatcggagga 1170421 aaaaatgaaa aagaaaacta aaattatact ttctctcttg gcagcactta ttgttatatt 1170481 gatagtactt ccagttctat ctcctgttgt ctttacagct tcttcggaaa aaggagcaat 1170541 cagacacgaa atttataaaa gaggatatcc ctaccaaagc tactttgcag ttctccagaa 1170601 aagagaagga gacaatgaat ctgggaatct ttattatgta aattggctag attggaaaga 1170661 tgaaacaggg caaactcctc acttatgcta ttcgaaaaaa tcatcagatg gtgaatacga 1170721 agtaagttgt ggcacagggc cgtaaaaata aattttaaaa ttgaataagt ccaagacgga 1170781 aagcctgcgg acactgatcg ttttacagag aaatttgtgc ttcgatcggt gtccgttttt 1170841 tttcgcaact aaccagatgt ctatcgcgat tactagctat gaaaggagta attagacatg 1170901 aaacagtcca aaaagaaacc atcacagaag caacatgagc gcttagatcg tttctggcaa 1170961 caaatgatga acactaacat gcaaacactc agacgtggca aaggcggcgc ttataaacgc 1171021 agaaagtaaa aagggagttt gaggatgatg aaaaacggat tcgcttataa aaacggaaag 1171081 cttgtgaata tcttttgcgg caaagaagag ctctataacg agttgaaagc cttcttggtc 1171141 aaaaccttca gtatcaacgt gaaagaggta tcgaggccct caatatatcg cagaacaaaa 1171201 agcaaacaac tggaatgaca cttactctat ttaactatca ggagggaaag cactatgaca 1171261 gatcaaatga ttgcatggga gattgaggaa tggattcgtg attataaatt catgctgcgg 1171321 gagatcaaaa ggctcaaccg tgtattaaac aaagtggatt ttattagcac aaagctcact 1171381 gcaacatacg gggaggaagc gggcatgcca aggggatcag caggcgtcag tcaggcagaa 1171441 ttgcggcaga tggaccgaag agaaaggcgg cttcacaaat atgaatctat tgtgcattac 1171501 ctggacaatg caatggaaca cattgaagaa gaaaagcacc gaatcgttta cgattgcatg 1171561 atggaaggca tgagctacac tgctattgca aaccaccttg attgctcccg ggataccatc 1171621 agaaagatca aaacagccat aatcggcaac atcgtcaata aagtcaaaga agccaacttt 1171681 ctgcaatatt tgaattcgtt taaatcggcg gtgtaaaatg gggggcagga tcggcgcggc 1171741 ggattattcc tgcgtcacca ccaatttcat acaatgagta aaacctccca gtggtaagcg 1171801 aggatcaact caactgggag gtcttacata gtgaatcggt gataaaacag cagcagtatt 1171861 gcgtacatgt taatatcccc gacaaaatat gtttttttca acagattcgt tcgacaaatt 1171921 ttgcaaattg ttaatcgata acttttcatt cccgatatta aaaatgggag tgaattgtaa 1171981 aatgaaaaaa cagaaaaata ataaaaagaa gaatattgaa aagcgaaata ttgaaaagcg 1172041 aaatattgaa gagaagaata atgaggactt agaagaactg gaaaatgcga tttatactta 1172101 tcacaaaaag gagctacttg ctttctttct tgaaaaaact cgaattggtc atgataagga 1172161 agaatacaaa aggttccaat ctcttcttta taagttggat attgaatgtt tagaatttgc 1172221 tatatcgaga ttttctcata tagatattat ccatgatcat tcaaaatatg ttccagcctt 1172281 tatcccttta tttgcagcat atctcaccat gttctttaat ttttatgaaa aacattgggg 1172341 agctttatct tttgctgctg gtacaattgc tgctattgtt tggataattg cagtagaaag 1172401 aaaacataga aatcaagcaa tttctattat gaaaatattt gaacaagtca aagagagaaa 1172461 agtgaaagac agatctaaag actgaaagga gaaaatatga ataaggataa attaaggtat 1172521 gcaatcttaa aagaaatttt tgaaggtaat acccctttgt cagaaaacga tattggagtt 1172581 actgaagatc aatttgatga tgctgtgaac tttttaaaac gcgaagggta tatcattggg 1172641 gtccattatt cagatgatag acctcattta tacaaattag gacctgaact gacagagaaa 1172701 ggtgaaaact acttgaaaga gaatggaaca tggtctaagg cctataagac cattaaagag 1172761 attaaagatt ggattaaata ataagagcat cctgcggggt gctttttttg ttccctgtaa 1172821 actgcttccg gtaagtctca ggatagacaa ttggcggtta acggcttgag cacggtggtg 1172881 gtttagaggg aatatctttt ccaaaacaac acgaatcaga agggggcggc ggtgaatgta 1172941 gatggccgaa aagcacattc aggcgtataa ggattacgtc aaaggcatga aatacaagga 1173001 ccttgccgag aaatacgggg tgtcagtgaa caccattaaa tcgtggaagc agcggcatgg 1173061 ttgggaaagg aaaaagggtg cacccattga aaaaagtgtg cacacaaaaa aaggcgggca 1173121 accgggcaac aaaaatgcat tagggaacaa tggcggcgca ccacagaaga atcaaaatgc 1173181 tgtgactcac ggctttttct ctaaattctt gccagaagag acgcttgaaa tcatggaaga 1173241 gattcaggag cgttcgccag ctgatatgat atgggatcag atacagattc aatatgcggc 1173301 cattcttcgg gcgcaaaaga tcatgttcgt ttctgataag gaagaaatga tcaaagagct 1173361 gaaaaagaaa aggtccctca tatctgaggt cagcgaaatt gaagatgggc ttgtcattag 1173421 ttttagtacg tggtttcgct acagacttta cagtgaaaca aacacctaac acatttcaca 1173481 ttgcttcaga ttgccttcaa acttgataat ataacttcta aaccttccta taaaatgaag 1173541 gttttttatt tgatttcaat ttttaaatcc tttacataca gcgattgatt aactcgagca 1173601 atcaatgtcg cagttatatt tatttttcaa gaaaatgtta taatgaaaag ccataaaatg 1173661 atgggagggg gaatttcgat gcattacata acggcatgtt taaaaatcat cagtgataaa 1173721 gaccttaatg agataatgaa ggaattcaaa aaacttgagg aagaaacgaa caaagaagag 1173781 ggttgtatta cattccatgc ttatccgctt gagccatcag aacgtaaaat aatgctttgg 1173841 gagatttggg aaaacgaaga agctgtgaaa atccatttca caaaaaaaca cacaatagac 1173901 gttcaaaaac aagaattaac ggaagtagaa tggttaatga aaagcaatgt gaatgattga 1173961 aaggctcttt aaaaagagac attcaatgac ttagtatcag ccacttgtga ctaagtagta 1174021 aattgttgtc caactcttat tttttctatt taatattttt tgagacgaaa atgttttttt 1174081 aagctgattt taaaatgtat tcaaagtcag ctctgtttga tttaatggat tatattattt 1174141 ggatagcttg ttaccatcat aatggagata ctccttataa attggaggtt aaaataatga 1174201 gtcattctca agaaaaaatt gcactaatta caggagcaag cagtcaaggg gatattggta 1174261 cggctatttg tcgtaagtta gcctcacagg gtatacatat cttctttact cactggaatt 1174321 ctgatacggc ctggatagaa gaatttcaac aagaaatttt acgtatgggt gtccgctgtg 1174381 aggcaatgaa aattgattta tcagatgcac atgctgcatt cacaatacat gaaaaaattt 1174441 cagataaatt aggatatcct tccatcctta ttaataatgc agctcattcc gcaagtgata 1174501 attatgtatc gttagatgct aaatcacttg atgagcatta tgcggttaat atgagatcga 1174561 attttcttct ttgtgttgaa ttcgcccgtc ggtttaaaaa atctaattta atatcaggaa 1174621 gaatcatcaa tatgacatca gggcaggatt taggtccttt gcctggggag ttagcgtatg 1174681 cagcaactaa aggagctatt tctgcattta ctaggtcgtt atcacaagaa cttgcaccat 1174741 tgggcatcac tgttaacgcc gtaaacccag gtccaacaga ttctacatgg atgacagatg 1174801 aaataagaaa ttttctttca cctaaatttc caatggggcg tattggcaca ccagatgatg 1174861 cagcacgaat gattgccttt cttgcaagtg atgaggctga atggataact ggacaaatta 1174921 ttcattcaga aggtggattt attcggggct aagctaatga aacacggtat acaccaatgt 1174981 atgatgtatt cccaaaacta aatctaaact tgaagcgaaa ataaggtccc ttctcttttt 1175041 agagggggac cttattttat tcatgcatgt tttgcatcca gaaaatctgg cggataaaga 1175101 ttaataaacc gttacatata cttttccgaa tactgcagta cctttaaaca aagtaatcgt 1175161 ggctttccct tttgatttag ccgtcactaa accattttga tcgacttcag caactttttg 1175221 gttatcagtc caataacgag tagctgaatt atttttaaca gaataggttt ctccaacttt 1175281 tagaggtaaa ttatagtctt gaatcttgat aacatgtgta ggtgaaatag aaatgttctt 1175341 tacttcagta ggtgtggagt ttatttcatg agctgaagct accccgctga ccgacagagc 1175401 taacgcagaa atcgataaag cagaaacaac cgtttttttg aaattcattt tgaaacactc 1175461 ctttaaagtt ttttgtcttg cactataaca attcaataaa agtaattatt ttccttgtaa 1175521 ataaatgtta ataatatgtg aacgatcaat tgatttgagc taagaatatt gtgtgccctg 1175581 cacagagttt gtatttatga tggaaaattg ctgagagaga atggccatcc ttaaaatgtt 1175641 aatagcacac atttgatggg tattagtttg ttgagcgtgt ggaaattttg ttacctgcac 1175701 tttatccccg aagataccaa atcacttttc ttcatcatgt tcttactttc gtactcatac 1175761 attagaaaat cttcgttcta aataggtgaa gaattggagt atttttatga atttctgctg 1175821 aatatacatt acatagcaaa ctcaaagagt ataaaaatcg cttttttccg gaagcttcgg 1175881 taaaaaacga aacttttgtc tctatgattt tgttttataa tgtaaacggt ttcttatata 1175941 gtatacttat actatcaatt tgctcaagta gatactgaca ggaaggatag aaaaacagat 1176001 ggaatacata aatacaagac aaaaagagat tttgtatctg ttgttatctg aacctgatga 1176061 ctatttagtt gtgcaagatt tcgcagatag ggtacagtgt tctgaaaaaa caatccggaa 1176121 tgatttgaaa gtgatcgagg attatctcaa tgagcattct catgcacagc ttattcgaaa 1176181 accagggttg ggcgtttatt tacatataga agaacaggaa aggacctggc taagccaaca 1176241 attacatact gaacattttt cttctaggca gcggagcgat aaggaaagaa tgctgcacat 1176301 tgcttatgac ttattaatga atccgaagcc tgtttccgca aaagacattg ccgctcggca 1176361 ttttgtcaat cgatcttcca ttaaaaagga tttatacgca gtagaagagt ggctgaagcg 1176421 ttttgatctc acactggttt ctaggcagcg gcttggatta aaggttgaag ggaacgaaag 1176481 aaataaaaga aaggcattgg caagaatatc tgatttgatt cacaatacag cgtttaccag 1176541 ccaatttatt aaaagtaagt ttttacatta tgaagtagac tttgtgacga aagaaatcaa 1176601 atcactacaa aaaaagcatt ccctctattt cacagacgaa acgtttgaaa gtttgttgct 1176661 gcatacattg ttaatggtcc gccgcatcaa aatgaagcag ccgatttcat tgtccccaaa 1176721 agaaatggcg gcagtaaaaa agaagaaaga atatcaatgg acatttgctt gtttacagcg 1176781 gcttgaaccg gtttttgcaa ttcgcttccc tgaagaagaa gccgtgtact taacattaca 1176841 tatattgggc ggtaaggttc gttatccatt gcagacagaa gagaaccttg aaaatgctgt 1176901 gcttcctaag gttgtagggc atttaatcaa tcgtgtttca gagctgaaaa tgatggattt 1176961 tcacaaggat caggatttga tcaatggttt gaacattcat ctcaatactg tgctacaacg 1177021 gctgagctac gatctttctg tagcaaatcc tatgctcaat gacatcaaaa agatgtaccc 1177081 ttatttgttc cacctcatca ttgatgtttt ggaagacatc aatcaaactt ttgatcttca 1177141 tattcctgag gaagaggcag catatttgac attgcatttt caggcagcga tcgaacggat 1177201 gcagggcagc agcgagacac ataaaaaggc ggttatcgtc tgccacatgg ggattgggat 1177261 gtcacaattg ctgcggacaa aaattgaacg gaaatatcac caaatcgctg taatggcttg 1177321 tattgcaaag gccgatttaa aggattatat caaaaagcat gaggatattg atcttgtcat 1177381 atccaccatt gcgctggaga atataacggt tccccatatt gttgtgtctc cgcttttaga 1177441 gcctggcgaa gagaagaaat taagtgcgtt tatacgtcag ctgggcgaat cacaccgcca 1177501 aaaacaaaaa acgtttcaga tgctgaacaa tacgactcct tttttggttt ttttgcagca 1177561 ggaggcggag catcgctaca agttaatcga acagctggcg acagctttgt ttgagaaagg 1177621 ctatgttgat aaggactatg cggttcatgc ggtgatgagg gaaaaaatgt cggctacaaa 1177681 tattgggtca ggcattgcca ttcctcatgc aaacgctaaa tttattaaac aatcagcaat 1177741 cgcgattgcc acattaaagg agccgcttga atggggaaat gaaaaagttt cgctcgtttt 1177801 tatgctggct gtcaaacacg aggatcaaac tatgacaaag cagctgttta gcgagctttc 1177861 atatcttagc gagcagccgg ccttcgtcca gaagctgacg aaagaaacca atgtcatgac 1177921 atttttatct catttggatt attaaaagca gggattattc cttgcttttt ttgttcatgg 1177981 cagggcttga gaaataaatt tgcgagtgaa gacgcctatt ctccagcaat gatctaaata 1178041 aaataagagt ttaatagttg gagaagaaat gttacactct tttctgtata tggtaaagaa 1178101 tgaaaaaaca cgattcggtt ggtagtccgg atgcatgatt gagaatgtca gtaaccttcc 1178161 cctcctcggg atgtccatca ttctttaata tcttttatga ggagggaatc gttatgaaat 1178221 taacgattta ctacgatggt cagttttggg taggcgttgt tgaagttgtg gacaatggaa 1178281 agctaagagc ctttcgtcat ctttttggca aagagccgag ggattctgaa gtattagagt 1178341 ttgttcataa ccaacttttg aatatgatgg cccaagctga gcaggaagga gtgcgtttac 1178401 aaggcaggcg tcaaaaaaag atcaatccaa aaagattgca gcgccaggtt tcaaaagagt 1178461 tgaaaaacgc cggagtaact tctaaagctc aagaggcgat aaagctagag cttgaagcaa 1178521 gaaagcaaaa gaaaaaacaa ataatgaaag aacaacgaga acatgtaaaa gagcaaaggt 1178581 atatgctcaa aaagcaaaaa gcgaaaaaga agcacagagg taaataatcc aaacaaaagc 1178641 aggcgcagtg cctgcttttg taattaagga ctctactttg taacatatat ccaatgttta 1178701 tactccgctg atttatgatt caatataaac cctaacttct ccaaggtttt ttgtgagcct 1178761 agattatcat gttcgcatct tgcggtgatc cgggatactg tttctcggct taatgcccag 1178821 tttattagtt tttgggcggc ttccacacaa taacctttgc ggcgatgact tttatttgtt 1178881 gcaaaaccga tttcaatcat gccattttcg tctgggtcac ctaaaaatcc agttccccca 1178941 acaatttcat aattgtcctt ctttacaata atccatgaat caaatccttt tgttccattg 1179001 tttttgacta aaatctcgcg gaaataaggt atcgcttcaa aaaaatcaga atttggccat 1179061 tcaccatttg tttcatagcc taattctttg atagcctgat gatcttgttt agacgcggcg 1179121 tcaagaaggg gaatatcaat cgtttgtaat cgtaatcgat tcgtttcaag gagaaccata 1179181 tatttaatcc tcttttcttt ttactgggaa taatgataac atataacaat tttctctggt 1179241 accttggcag tagagaaaga tgaaaaaatt gagggggatt gaaagagtga caggtgagag 1179301 tttgcccaga ccaaaaacgg gtaggaaaat gctgatgtta atgtgtccct acccgttttt 1179361 ctgttcctga atgcagggtt tctgataaca tgttgtgcta ccttttcgca atcaaataaa 1179421 gcgatatggc tctttgggtt tgcacaggat tatgaatgat aatgacccat tggtttcttc 1179481 gtcttggaaa gcttgctacc gcatacaatg gagcagtatc gcgcggagtg aacccaccat 1179541 ttatcacgtt gatatctctt ccttcaagat gacaaactaa gtattcacct ggattgatga 1179601 cctgttggtt cgtccatgcg taagaataaa agccgtctcc aagatcttcg gtggaagatg 1179661 gggggacaaa gccatctaca gtcaatgtga tttctcttct tcgctgtctt tctgaaaagt 1179721 ctggacttct ttgagggtta tgagtatgtg aaaagtaagg aattaacgca gggccataaa 1179781 agtaatgata caaagcaacc actcctttat tttccattca tacaaattgt atgtgggagt 1179841 tatttgttca ttcctgtttt gttccatgta gactaataat gggctatagg cgtccaagga 1179901 aatcaatttg tccttccgtt gattcaatgc tagtaacctt gaaaatgcag gttaggatga 1179961 tagaatttac atattactgc aagaagttag acatacatca ttttgatagt gggtgaaaac 1180021 aatggcgaaa aaaatggcaa aaacaaatgc ggttcgtctg atagaacagc agaacatctc 1180081 ttatgaggta ttagggtata aaacagacgg ccagccggta gatggcatct ctgttgcgga 1180141 aaaaatcggt tattctttga aatatgtata taaaacgttg gttgcagcag caggaacaaa 1180201 tcattattat gtctttgttg tacccgttgc agaagagtta gatgtaaaaa aggcagcaaa 1180261 ggtgacaggg gaaaagaaaa tagaaatgat tgcaatgaag gagctgttag cggtaactgg 1180321 ctatcttcgc ggcggctgct cgccaattgg catgaaaaaa ttgttcccga cctatattga 1180381 tgcatctgca gaaacgcttg attttattat tgtcagtgca gggaaaatcg gtatgcagct 1180441 aaagttggcg ccacaagatt tagccagatc atgtgatgcc gcatttgcag aaattgtata 1180501 gatgcagata taggggaacg aaaaagctta gtcatatcga ttaagctttt tccgcatccc 1180561 tttcaaatat gatttcaaaa taagcagctg ccccataccc atctatactg ggagcgaaaa 1180621 tctgaacgaa tctccagcct cttttcgcat aatcatggat gatttgctgg tagtcttctt 1180681 taggccttct tctcatcgta ctcagctcaa ctcttacgaa ttcatattct ttcatcgttt 1180741 gatccctcct attaaggtat acgtaaaatg gagcgagaag ttccgaaaac ctaggttaag 1180801 gtcggaaagt atatttcact cactaaacaa atccatttat gcctgatgcc tgcatgcatc 1180861 tgggaagagt taaggggcta taaaaacgaa ttttaccggg tcagcagtcc aaatgaatct 1180921 cttgcttatt gcatttgact gagtatataa gtaaaaaaag agcggccaga acatataaga 1180981 aggagatgat cattaacgca ctcataacag ggtagtgttt agcggagtag atgaaaaaat 1181041 caagctgtga aatttgtttg gggctgctga cggcatcaat tccattaagc agttttgaga 1181101 gtttagcagt atagttccaa tcaaatcgat ctgaaacaag ctcgcttcct tgataccaat 1181161 taacagcagc taaaaacaga aataccataa tagaaaatcc aagctgaaca actaaaaata 1181221 ttcccttcac ttttgtatga cctccaaatc tatgaatatg ggaaaatcaa acaatatatt 1181281 accaccgtat gggttattct tgcaatttca cttccataca actcaaacgc aagtctattt 1181341 ttttgtttgt ttttggctta taatacctga tgatggaaaa agagtgcggg tttatagatt 1181401 agagaaacaa atgtatttct tagcattttt tatttgtgga gagagtatag aagcattcga 1181461 ttagatctgc tttttcacag aaacggtttt catctgtttg cctgagcttt acaattggct 1181521 ggcaaaaaaa caatgatttc tttcaatcaa aacatgcaac gatgcgacac attttatatc 1181581 ttgatgactt atttcattgc ctttaagtca tcctatcgag aaagcgatgg tattttatga 1181641 acaaagaaac cctaaaaaac atactcatga ttttttcaat atgcgcaaca ctccgagaaa 1181701 ccgatggtat gcgcatagct gatagctgga ttttgagtga gattatacga tttttgattt 1181761 gcatggttgt gttttttgcc atgacatttc tattagatgc tgtttttcca aacaaaaaag 1181821 agtcacatta atgtgtggct ctttttgcat catctgatca gaaacatcat aaatgaatcg 1181881 atcatcatga tgaagaacag caagcaaaaa taaataagcg agtagacaaa catatccttt 1181941 gcccacttca cgtcatcgtc tgttttgaat cctttgatgc tttttttgat ccatatgcct 1182001 ccgagaacca aggcggctaa gaaataaaat gggcttatat ggccggtgcc gagagagaaa 1182061 ggaaataata gcgtgaccgg caccaggacg gcaatatatt gcatcatttt tatttttgtt 1182121 acatgattgc ctttgactac tggcaagagc ggaacgccag cagcgcgata ttcctctttg 1182181 cgtcttatcc caatcgccca aaaatgcggc ggctgccaca gaaacataat cgtgtacaac 1182241 agcactgctg tcatactgaa gtcaccggtt acggcacaat accccatcaa tggcggcgca 1182301 gctcctggga agctcccgac aaatgtgctc cacacagacg ttcgtttcac ccataccgta 1182361 tagatgatcg cataaaaaat aaaggcggcc agtccgagaa aggccgttaa tggattgagg 1182421 gaataaagca tggcaagacc tgcgattcct aaaacagagc catatgttaa gatcatggct 1182481 ggcggcattt tccctgtgac cgaggccctg ctgcgagttc gtgccatttt tgcgtccata 1182541 tgccgatcaa aatagttgtt atagacagtg ccggaagcca tcacaaacgc ggttcccaac 1182601 attgctgtta ccattgtcat caaaaaagcc aagccggtta acgttttttc tgcgcttgca 1182661 aacgcgatcc aaaacccgcc gaaggctgct atcgagtttg atatgataat gcccggcttt 1182721 gcaagtttga taaaatcgta aatggttacc cggttcgaag cttttatgta ttttgtttca 1182781 gatatggctg cagaatctct tgtattctcc aaaaatagac gcctccccca aaactgcatg 1182841 cttttgttat cgtaacaaga gggggacaga atcacaatta tttcccatat ttgtcatgat 1182901 attgtcattt ttaaaacaaa aaaatgggga gctggactgc ccccattttg atatgtggcg 1182961 actagtaacc gtaacctccc ccatatcctc cgccataacc tccgccgtaa ccgtaccaag 1183021 ggtagtaagg cggtcgcggg cgcgggtagt aataaggcgg gcgcggataa aacgggtaga 1183081 acggataata cggtcttgga taataataag gcggataaaa tggcggtctc ggacgcggat 1183141 aataataagg ctgtctttca tcataagggg taatttgttc aaatgactgt tcattcaaag 1183201 ggtaatccaa gaggaaaacc tccctagctt tttttattcc ttttaccata ttcctgatgc 1183261 ttaagttggg tgtatgtaca ttcatgaaat tcggtttttt ttatgatgaa attccttaaa 1183321 aaggattgac atgaacttct aaatctcata gtattacaaa tgtgaaataa atgttactac 1183381 aatgttacaa aaacatttct aaatagatac agttccaact gatgaagagt aaatcgaaat 1183441 ggctacgaaa gaaggagttt ttgttgttgg caaaaagaat caaatggttt catgtattaa 1183501 tagcagttgt atgtgtggtg ggccttatcg gctttttcca taatcattca ttgaaaaaag 1183561 aaacggtcat gaataaagta agaactgatt ctcaatatgg gaatgttgag atcgcaacgc 1183621 ttgtgaatga cgggaaaact tttaattacg cggtaaacta tcctgttttc aaaaatgaaa 1183681 aaatggattc ggcattaaaa agattcgcag aaaaagaggt tcgtcaattt caaaaggaaa 1183741 caaaggacgt tgaccaagag catacgacaa aacgcaacga attaaatgtt gattataaaa 1183801 ttgtccatta tgccaaacag acagtggcga ttgtatttaa tgaatataaa tacatcggcg 1183861 gggcacacgg gcaaaccgtg aaaaaaacgt ttaactatga ttttagtaaa caagcgtttc 1183921 tttccattga tgatattttc aaagaggacg ctgactactt acataagctt tcgttaatcg 1183981 cttatcacga gctgaaaaag aataaggaca ttgccgcgga cgatgcactg ttaaaggaag 1184041 ggacggctcc gaaaaaagaa aatttcagcc gctttgccat caaggaggat tatatcgaac 1184101 tttactttga cacatatcag gttgcagcag gctatcttgg agagcaatcg attgccatta 1184161 agaaaagtct tttgaaagac attctgaaag aacaatatat tgataaagca aaaaataaaa 1184221 ataaaatcaa agaacaaaag ccgaagcatg aagtgatttc tttacccaaa gaggaaacag 1184281 ttgatccaaa tcaaaaagtc attgcgctta ctttcgacga cggcccgaat cctgcgacaa 1184341 caaatcagat tctagactcc ttgaagaaat ataagggtca tgccacgttt tttgttttgg 1184401 ggagcagagt tcaatattat ccggaaacgc taataagaat gctgaaagaa ggaaatgagg 1184461 ttgggaacca ttcatggagc catccgcttc tcacaaggct ttcagtgaaa gaagcgttaa 1184521 agcagatcaa tgatacgcaa gacatcattg aaaaaataag cggatatcgt ccgacgcttg 1184581 taagaccccc atacggcggc attaatgatg aactgcggag tcaaatgaaa atggatgttg 1184641 cgttatggga tgttgacccg gaagattgga aagaccgtaa caaaaaaaca attgttgacc 1184701 gtgtcatgaa tcaggcggga gatggaagaa ccattttgat tcacgatatt taccgcacct 1184761 ctgctgatgc ggccgatgaa attataaaaa agctcaccga tcaaggctat caattggtga 1184821 cagtttctca gcttgaagag gttaaaaaac aaagagaagc gaaataaatt agaaaaggct 1184881 gtccgtacgg acagcctttt ttctatttaa taagagcctg tggtggccca aacatttaag 1184941 tttggtcctg aatacttgcc gaaagcgtaa gaagtccttg gatctaaatc atataccatc 1185001 ggtgtatagc aagacttttg gccggccacc gcttttccat tgccgcctgc agaatcacaa 1185061 ttatatcttt ttccgtctgt gttccgggta atctccgcat ttgcttcata gccagacgtc 1185121 aatgtattat tcatcgtgat ttttgcccaa gccgttttac atgtactgct gaatttaagc 1185181 tcgactactc cgatgacttg attgctggca ttcactaagt ttgaggattt ttttgtagag 1185241 ccgctggacg cacaatcatt gtaataaggg ctttttccat cgtaggcatg ggtttccgcc 1185301 ttggcgggtg cacctttgac ggcaaaaaca aatactactg cgaataacac caatgaagcc 1185361 ttcataaaca gtcttttcaa tttatgacct ccttaatatg gcaaacaata aatcatatgg 1185421 aggaacaatc aaaacatgca tgcttttttg tgaacaataa aggcggccgg gaggatggag 1185481 ttcttggccg cctctggtat gaggttatgc ttttacatca atggtttgtc cgagagttgg 1185541 atgttgaatc atctttaagg tttgatcggc attttgctgg gcggtgtcca gccttttttt 1185601 cgttaaagca atatttacat tctgggcaag ggatgcttga tgcatcgcaa ccgataaagc 1185661 aggaatatcc atggttccac ctcctatgcc ttacctatcg gcgggtttgt atgattttac 1185721 agtgaaaaat ggcttaattt ctcttgttga cccttacgct gcggcatatc gtatgttttt 1185781 gacaaggagg gaatcaggat gaatctagta atggaaaaga cctttgagca atacgaaaag 1185841 ctgttttcaa tggaagaaca gaaaagagaa gatgtatttc ggtatacgat gatgaggccg 1185901 tttgaaaaga tgtggaccgc catccaagtt ccgctgaaag cgaaggagcc aaacggctat 1185961 gatgtgatca tggctgcgaa aatgctgggc tatttggatg tccgtgatgc tgaaagcggc 1186021 cagaaagcac tacaaatact gaaagaatca catgtttcag agacagctga atctgcactt 1186081 cggcaatgca tattttttgc tgagcgcgaa cagctgcggg tgaatgcaaa ggagatcaaa 1186141 ttcggccttt atatcgctga tccaaataag cttcagctgc aaaaaggcta ctgcgggttt 1186201 ggcgggatac cgggctttat tcatgtatgg attaatccga acagttataa cctgccaagg 1186261 attccttcca ttattgctca tgagtttcat cataatgtgc ggttttcgta tatagatttt 1186321 catcatggct ctgtaagtgt cggggattat cttgtgattg aaggattggc ggaatcattc 1186381 gccagagagc tgtttggtac ggaacgattg ggcccttggg taactcgttt tgatcatgaa 1186441 gacttgcaat attccattga tgtgattaat gaggtgctgg atgtgaaagg attttcggaa 1186501 gtcagccgtt atatgtttgg tgatccaatt gctaacgacc aaggctttaa gcctgcaggt 1186561 ttatcggctt ttgcgggtta tgcagttggc tatcatgccg ttcagtcatt tatgaatcaa 1186621 catcatatca cgataagcga ggccacacgt ttggatgcga agaccattat ttctcaatgc 1186681 ggtctgtttt ctacatgaaa aaagcgtcac atacagcggc gctttttgat tcccaaaacc 1186741 agcagttcta tggcggcaca ggcggcaatt ccgattgtat atgcttcgat atcgctccat 1186801 aaaaaaccgt accctagtac aagcccgcca agagaagtat ctctaatctg gtcgatccat 1186861 tcggcatgat agagctggct gaattcaatg acaaaacaga aagaaagact gataatgccc 1186921 gttatcattg tcttcagctt ccgaaataga aatccgcatc ccgtgaagat catggcggcc 1186981 cacaacgagt ctcccagata agtattgagg gtatcaggaa gaacactgga gaatgctctg 1187041 gatccaagcc ccagcccaat gatcagtatg gtgaaaactg catatatcca acgatttcgc 1187101 ttcattgcga attgataccc cgtctctgct tcatctccct gtattgtaag gaatatagct 1187161 tttatttgtc cactaaaaaa gcggctgaat agccgcgtag ggtgtttatt ttgcttttag 1187221 gtttacatgg tcggctgtct gatccgtgcc tattacaaaa tggagttcat agcggcctgt 1187281 atcatataca taatcgattt catcggtaaa cgggacggtt aacacccgat ttactggtcc 1187341 taattgcttc tgcagcactt ccggcgtaac tccgcctaaa ttcagctgcc gttccacacc 1187401 ggttccaaag tagcggattt ctgaaattgt catgtcttta tgataggaaa atccgtagcc 1187461 cggctgtccc atattccagt gatataaatc aaatcgattg tctcccccga ctggtctttc 1187521 cggttcccca aacgcagcgt ggacatcccc ttttgtgctt ttgttaatgg taaggccttg 1187581 cgcctgctga ggcatttccc ctttataggc ggtgttatag aggtttttga caagctcagc 1187641 ggctgattga ttcgtgtttt ctgagagtgt gtttgtttga gctgcggcct ttgccggtgc 1187701 tgaaaaggac gcagccccaa agccggtaaa acagcttgtt actgctgctg ccgcggttat 1187761 agcagacatt gtctttttca tgttaatccc tcctaattga tctaccattc cgtttccccg 1187821 tgtttttgca acgaaacatg tgagtgcgct ttgtatgttt tattgagttg ttgtaaggga 1187881 actgaaatag gtaattcggt atataaagca agaaagggga atggagatgg ctggcaagaa 1187941 aacaatcaca ataaacggcg ttgaaatgga agcgtccgag gaacagacgg tgctgcagct 1188001 tttgaataac agctcgattg aagtgccgca agtttgctat catccaagct tagggccgat 1188061 tgagacatgt gatacgtgca tcgtcagcat caatggtgag ctgaagaggt cgtgctccgc 1188121 tgaattaaag gatggggatg tcattgatac gctctcacct gacgtgaaaa aagcgcaggt 1188181 catcgggatg gacaagattt tatataatca tgagctttat tgtacagttt gcgattacaa 1188241 caatggggga tgcgaaatac ataatacggt gaaggaaatg aaaatcaatc accaaagcat 1188301 tccgtttgat cacaagccat accataagga tgaatcccat ccgttttatc ggtatgatcc 1188361 agatcaatgt atattgtgcg gacgctgtgt tgaggcatgc caagacgttc aggtaactga 1188421 aacgctgacc attgactggg agcggaaacg cccgcgcgtc atttgggata acgacgtgcc 1188481 gatcaatgag tcgtcatgtg tgtcatgcgg ccattgttca acggtctgtc cgtgcaacgc 1188541 gatgatggaa aaaggaatgg aaggggaagc cggatattta acaggcatca ataacgaaac 1188601 gctgcgaccg atgatcgaga tcacgaaagg cgtagagaca ggctacggct cgattctcgc 1188661 gatttctgat atggaatcgg ccatgcgtga tgaacgaatc aaaaaaacga aaaccgtctg 1188721 cacgtattgc ggcgtcggct gcagctttga tgtctggaca aagggcagag acattctgaa 1188781 agtagagccg caggaggaag cgcctgccaa cggcatttct acttgtgtga aaggcaagtt 1188841 cggctgggat ttcgttaaca gcgaagaacg cctgacaaag ccgctgatcc gtgaaggcga 1188901 tcatttccgt gaagcagagt gggaggaggc gttattgctg atcgccagca agttcactga 1188961 attaaaagag gcgtttggcc cggattctct cgcttttatt acatcttcta aatgtacaaa 1189021 tgaagaatcc tatcttatgc aaaagctggc cagaggggtc attggcacaa ataatgtgga 1189081 caactgctct cgctattgcc aatctcctgc gactgccggc ctgttccgga cagtcggcta 1189141 tggcggtgat tcaggatcaa ttacagatat cgcgcaagcg gaccttgttt tgattatcgg 1189201 ttcgaacacg tctgagtcgc atccagtctt atccactcgg attaaacggg ctcataagct 1189261 gagagggcag aaagtgatcg tcgcggatat cagaaagcac gaaatggcag agcgctcaga 1189321 tttatttgtc cagccgcgtg ccggatcgga tatcgtctgg ctgaatgcga tcgccaaata 1189381 tttaatagaa aacggcaagg ccgatgaacg atttttgaga gaaagagtga acggacggga 1189441 tgaatatgta aaaagcctcg cgccgtacac acttgaatat gctgaggaga aaaccgggat 1189501 tgatcaagaa acccttatcc aaatggcaga gatgatcggg caagctgaca gtgtgtgcgc 1189561 attgtgggcg atgggcgtga cacagcatat tggaggaagc gacacgagca cggcgatctc 1189621 taatctgctg cttgtgacag gaaactacgg aaaaccggga gcaggttctt acccattgcg 1189681 cggccataac aacgtgcagg gagcaagtga ctttgggagt atgcctgaca gactaccggg 1189741 ctatgaaaaa gtgacggacg aacaagtccg ccaaaaatac gagcgtgtgt ggggtgtgcc 1189801 gctgccgaag gagccgggta tgaccaacca cgaaatgatt gaaaaaatcc attccggaca 1189861 gttgaaagcg atgtatgtaa aaggtgaaga aatgggcctt gtcgactcca atatcaatca 1189921 tgtacacgct gcatatgaaa agcttgattt ctttgtggtg caggacattt tcctttcacg 1189981 tacagcggag tttgctgatg tggttcttcc tgcgagcccg agccttgaaa aagaaggaac 1190041 gtttacaaac acagaacgcc ggattcagcg tttgtatcag gtatttgaac cgctgggtga 1190101 atcaaagccg gattggcaga ttattatgga ggttgccaat aagcttggcg ccggctggct 1190161 ctatgagcat cctgcagaca ttatggagga agcagccaag ctgtcgccga tttatgccgg 1190221 tgtcacctat gaacgtcttg agggctataa ttccctgcaa tggcctgtaa acgctgatgg 1190281 aaaggattcg cctttactct ttacagagcg cttccctttc ccagacggca aggccattct 1190341 ctaccctgtc cagtggacag agcctaagga attcggtgag gaatatgata tccatgtcaa 1190401 caatgggcgg ctcttggagc acttccacga agggaacctg acttacaaat caaaagggat 1190461 ttcggagaaa acaccggaag tgttcttaga aatttctcct gagcttgcgg cagaacgagg 1190521 gattcaggac ggaaccctcg tcagactcac atcgcctttc ggaaatgtca aagtgaagtg 1190581 cctgattact gatcgagtca aagggaagga agtatatctg ccaatgaacg attcagggga 1190641 agcggcgatc aacctgttaa caggcagcca tgccgataag gataccgata cgcctgctta 1190701 caaagaaaca tcggccaaga tggaaatttt gaagcacgac ggaatcagcc cgctgcctaa 1190761 gatcaaccac cgcaacggca atccgcagcc gcaaatcggt gtgcaggttc ataagaaatg 1190821 ggcgcggaag gattatattt tccctggtga cgctgtgaaa agggggatgg gccataatgg 1190881 ctaaagcgat taaacgaatc caaaaaatcg aggtaacaga agaggatcag cgaaagcgtg 1190941 atttgcggga aattgaagat gctctaattg accacaaaga agcgattctc gaaacattgc 1191001 atatgctggg ccatatgaac gagcgcgggg tcctgccgtt gctccgcggc ctttttggtc 1191061 aaggggataa agttcttgat atcctggtga aaaaggcaga tacagaggaa acagccaata 1191121 cgctgaaaaa tctgcttctt ctgtttggaa cactcggcat gctggacgtg aagcagctgg 1191181 agcctctcat tttgaaagtg aatgcgggtg tggcaagcgc tgtagagcag aaaaacagtg 1191241 aagaaaagac aggttatttt gatattatcc gctcgctaaa agacccggaa atcaacaaat 1191301 caattacact gctcttttcc tttttaaaag gaatgggaca agatacaaag gagctggaac 1191361 gcacgacgca gcctccggaa caccaaaaac atcatcagga accccgagag aaaagaggaa 1191421 tgaataagcg agattgacct cccacccgag cggcttcagc cagctcgggt tttttgatga 1191481 aaaggtctaa tggactagta aaaaatattc aaatactagg aagaagtaag attgtgatga 1191541 atgagataga aataatcgtt actttcttac ctgttaagaa aagggaaaat ctgattataa 1191601 tagaaatcga ttactttaga tgggggaaca atcatgaaaa aagtcttatt actattattt 1191661 gtcttgacga tcgggttagc gctttctgcg tgcagccaat cgagcgatgc gtcagagaag 1191721 gaaaaaccga aagagaaaaa atcgcaagaa gagcttgaaa aggaacttga taaggaattg 1191781 aaaaaaggcg gtgagccgaa gaccaaaaaa gatgatcaaa tacataaaat aggagaaaca 1191841 tttaaagcag gacatacgaa ttttacagtg aataaagttg atagagtgca aaaaggtgaa 1191901 tatatgaatg ttggcggagc tgtaaatgag gagacaaaaa caataaaaga tgatgaggaa 1191961 cggcttatta tagaagttac gatggaaaat ataggggaag attcaataag ctacaatttt 1192021 atcgggtttg atttaagaga taagaatgat caatcagtgc ggcctgtttt ttctatagaa 1192081 gagaagggca gaatccttat gggaggaaca ctagtatcgg ggaaaaaggt tacaggtgta 1192141 ctcagttatg tcatccctaa aggagaacag aaacattaca cactggtata taatccgttt 1192201 ttagctgata caaatagcag taatacagaa gagagagtaa aggacgatat tgattacttg 1192261 gtgaagttag attagatgct aatttacagt tgcacgtttt tcatctgtgg aaaacgtgca 1192321 ttttttatag cgaaacttga cttgaaagga tgagtgataa aagtgcaaac caaatggctg 1192381 gaacgggcac agcggattcg ggcgatcgcc caagcggggc ttgctttttc caaggatgtg 1192441 tacgacaggg agaggtacga agagctaatg aagcttagcg cggaaatgat ggcggattac 1192501 tcggagaagg acattgaagt tatcactgat ttatggcaag gcgagaaggg ctatccaaca 1192561 ccgaaagcgg atgttcgcgg cgctgtattc agagagaatc agattttgct tgtccgggag 1192621 aagcatgatg agctgtggtc gctgccgggc ggattttgcg agattggttt atcgccggct 1192681 gaaaacgttg tcaaggaaat caaagaagag tcggggtacg atacagagcc gtctcgattg 1192741 ctggccgtgc tagacagcca taaacactct catccccctc agccttatca ctattataaa 1192801 atcttcatcg catgcagcat gacggacggg cagggggaaa cagggatcga gacgaatcat 1192861 gccgcttttt ttccggaaga cagactcccg ccgctttctc ctaaacgaaa cacaccctca 1192921 cagcttagca tgctgtttga ctttttgcgc catccggaca agaaaacgat atttgactaa 1192981 aaaagaaaga gcctgtgggc tctttctttt ttataatgta atgtgttttt cgttggcgag 1193041 tttcagaagg gtcaaaatag aatcggcttg tttatggccg agtttttgct ttaatttgtt 1193101 ttcttcaact aatcggctgc cataaatttt gacggaggct ttgtcgacga cagtatgcca 1193161 gttttcctgt ttttttccct caacaagcgg tttttcatgt ctctcagaaa aagagaacac 1193221 aaagagtacg aatgcaagtg aaagtaggat tccgacaact tgttttttgt aatcagtctg 1193281 tgctgccacg ttgttctctc cttcaccttt taccttctat ttaatcatag aaccaaatta 1193341 ttttacataa tgggaaagtc atttttggag ttagtgcatt tggttgaaaa cagagacgtt 1193401 ttttgagcgg agcggtgcaa ttgaatccat attggatttg cgtgcttatg cctaaggtca 1193461 cgttgtgagc caaaacagca gtgcagaata gaaaaaaatt gaaagattat ggtaagatga 1193521 acgaaattcg agggggaata tatgatgcct gcatcgaaca tcgtgatcgc ctgcctgctg 1193581 ttatcaattt aattatttgt ggtagtccct ctctttttcg aaagcgggag gtgaagtgga 1193641 acattaattg ctgaattctt tcaaggggag tgaccgtaca tgaatgtgtt aaaccgccgg 1193701 caagccttgc agcgagcgct gctcaatggg aaaaacaaac aggatgcgta tcatccgttt 1193761 ccatggtatg aatcgatgag aaaggatgcg cctgtttcct ttgatgaaga aaaccaagtg 1193821 tggagcgttt ttctttatga tgatgtcaaa aaagttgttg gggataaaga gttgttttcc 1193881 agttgcatgc cgcagcagac aagctctatt ggaaattcca tcattaacat ggacccgccg 1193941 aagcatacaa aaatccgttc agtcgtgaac aaagccttta ctccgcgcgt gatgaagcaa 1194001 tgggaaccga gaattcaaga aatcacagat gaactgattc aaaaatttca ggggcgcagt 1194061 gagtttgacc ttgttcacga tttttcatac ccgcttccgg ttattgtgat atctgagctg 1194121 ctgggagtgc cttcagcgca tatggaacag tttaaagcat ggtctgatct tctggtcagt 1194181 acaccgaagg ataaaagtga agaagctgaa aaagcctttt tggaagaacg agataagtgt 1194241 gaggaagaac tggccgcgtt ttttgccggc atcatagaag aaaagcgaaa caaaccggaa 1194301 caggatatta tttctatttt agtggaagcg gaagaaacag gcgagaagct gtccggtgaa 1194361 gagctgattc cgttttgcac gctgctgctg gtggccggaa atgaaaccac tacaaacctg 1194421 atttcaaatg cgatgtacag catattagaa acgccaggcg tttacgagga actgcgcagc 1194481 catcctgaac tgatgcctca ggcagtggag gaagccttgc gtttcagagc gccggccccg 1194541 gttttgaggc gcattgccaa gcgggatacg gagatcgggg ggcacctgat taaagaaggt 1194601 gatatggttt tggcgtttgt ggcatcggca aatcgtgatg aagcaaagtt tgacagaccg 1194661 cacatgtttg atatccgccg ccatcccaat ccgcatattg cgtttggcca cggcatccat 1194721 ttttgccttg gggccccgct tgcccgtctt gaagcaaata tcgcgttaac gtctttgatt 1194781 tctgcttttc ctcatatgga gtgcgtcagt atcactccga ttgaaaacag tgtgatatac 1194841 ggattaaaga gcttccgtgt gaaaatgtaa tagataagga gactggagat tcatgaaaaa 1194901 gtaccatatt tcgatgatca atatcccggc gtacggacat gtcaatccta cgcttgcttt 1194961 agtagagaag ctttgtgaga aagggcaccg tgtcacgtac gcgacgactg aggagtttgc 1195021 gcccgctgtt cagcaagccg gtggagaagc attgatctat catacatcct tgaatattga 1195081 tcctaagcaa atcagggaga tgatggaaaa gaatgacgcg cccctcagcc ttttgaaaga 1195141 atcactcagc attctgccgc agcttgagga gttatataag gatgatcagc ctgatctgat 1195201 catctatgac tttgttgcgc tggctggtaa attgtttgct gaaaagctta atgttccggt 1195261 cattaagctc tgttcgtcat atgcccaaaa tgaatccttt cagttaggaa atgaagacat 1195321 gctgaaaaaa ataagagaag cagaggctga atttaaagcc tacttggagc aagagaagtt 1195381 gccggctgtt tcatttgaac agttagctgt gccggaagca ttaaatattg tctttatgcc 1195441 gaagtctttt cagattcagc atgagacgtt cgatgaccgt ttctgttttg tcggcccctc 1195501 tctcggagaa cggaaggaaa aagaaagcct gttgattgac aaggatgatc gcccgcttat 1195561 gctgatttct ttgggtacgg cgtttaacgc atggccggaa ttttacaaga tgtgcatcaa 1195621 ggcatttcgg gattcttcat ggcaagtgat catgtcggtt gggaaaacga ttgatccaga 1195681 aagcttggag gatattcctg ctaactttac cattcgccaa agtgtgccgc agcttgaggt 1195741 gttagagaaa gctgatttgt tcatctctca tggcgggatg aacagtacga tggaagcgat 1195801 gaacgcaggt gtgccgcttg tcgtcattcc gcaaatgtat gagcaggagc tcactgcaaa 1195861 tcgggttgat gaattaggcc ttggcgttta tttgccgaaa gaggaagtga ctgtttccag 1195921 cctgcaggaa gcggttcagg ctgtatccag tgatcaagag ctgctcagcc gcgtcaagaa 1195981 tatgcaaaag gatgtaaaag aagctggcgg agcggagcgt gcggcagctg agattgaagc 1196041 gtttatgaaa aaatccgctg tcccgcagta aaaacataaa aaccgaaatc aatttgattt 1196101 cggttttctg tttaaatatt ttttttcatc ccgcatctcc ggcattctct aagaaatttt 1196161 ccgcctttta cagagctttt gaacagtgtg taatcacagt tgtcgcagcg cccgctgcgg 1196221 gcatccggat attcattgaa ttcgtaaaca atcgatgtat cgtagccttt tgtttcatat 1196281 tcttcttttt tggtttccat gtcgatcctc cgttacaaga cgtgtctgct gtttatctta 1196341 cagcaagctt ccggcgtatt caatggattt taggaggttg ggtttatctt gatttctccc 1196401 ttggtttgcg ccaaaatagc tttattaagc ttatatacat aaaaagccta tgcaaagagg 1196461 agaggaaacg ggtatgggaa aagggttact tggaaaacgc gtggcaatcg gtggctcacg 1196521 aaaaacggaa gaaattagta caatcattga aaaacagggc ggaatacctg tcatccggcc 1196581 tctccaaggt acagtttact tagcagagaa gcaggtggag ccggatttgc ggacgtttgc 1196641 ggaagaaaaa gctgactggg tcattttcac gacaggcatc gggttggaga ctcttgtcga 1196701 tatggcagag aaaattggac tgaaagatga gtttctgcag gccattcgcc aagcgaaagc 1196761 ggcatgccgg ggatacaaaa cgctgtctgc gctgaaaaag cttggaatca caccggaagc 1196821 ttcggatgaa gacgggacaa caagaggctt aatccgttcc ttggagcctc acgacttttc 1196881 aggaaaaaca gtcatggtgc agcttcatgg cgaaaaagcg ccggctctca tggcatttct 1196941 tgaagaaaaa ggcgcgtctg tcctgccgat tctgccttat cagcacatcc cgccggagga 1197001 ggaaacggtg gagcggttat gccgagagct gatgaacgat gaggtcgatg ccgtttgttt 1197061 tacaacggcc attcaggttc gttccctgtt tgattttgcc aaggggcgag gttatatcaa 1197121 tgaagtgaag aaggtattcg aagaacgcgc catcgcagct gctgtcggaa aagtgactgc 1197181 tgaagcactg cgggaagagg gcattacgag actgcttgcg ccagagattg agcggatggg 1197241 tgcgatgatt gttgagctgg ccaagtatta tgaagaaaag gaataacaag tacaaaaagc 1197301 cgcttttccc tcggaaagcg gcttttgtct gtcattcatt ttgcttcagc tgctgatgaa 1197361 cggtgaataa tgatgggtat gtcagcacgc ttaagattac acaagtcagc gcggctgagg 1197421 ccatcgttgt aaacacgatt aagagttgaa agcgtactgc ctgaatcggg tccgcgccgg 1197481 ctagaatctg gccagtcatc atgccgggaa gctggacaag acccagtgtt ttctggcttt 1197541 cgagcgtcgg gatcatactc attttcatcg ctgaggtaag aatgcgctgt atggattgct 1197601 tcggtgtgcc gccaagtgac aatattaatt gaatttcttc tttgcgaacg ccgacttctg 1197661 agttaagccg gtttagaaac aaacttgaga gcaccatcga atttccgatg accatcccgc 1197721 tgatcggaat gacatatcgt gccgtaagcg gaatgatatg aagagacagc agaattccct 1197781 gcgtcacaat ttctacgatt gctaacgcgg caaacaccct ccaaaacgaa ccgatagtat 1197841 ttttctttcg cttgatgaca ttttgcgccg ccaccgcgag cattaacagc accatcagca 1197901 ggataaaaac agggtggtct ccgcgaaaaa tcagcgacaa aacataaccg atgataagca 1197961 gctgcaccgc ggcccggatg gtggcgatga tcatgtcttt ttctacaccg gctttaaagg 1198021 attttgataa aaacaaggcg atcaaaacaa agatcatcgt taaagagaga gaaaggtaat 1198081 ccattaccga gtgcctccct tcaaaaattc tttcgctgct tcatgctgcg gagcggagaa 1198141 aaatgtgtcg gtttcagcga tttcaagcag ccggccatct gccataaacc aaatggtatc 1198201 ggctattcgt tttgcctgct ccatattatg agtgacccac atgactgtcc attttttctc 1198261 ttgatgctga cgtttgatca gttcttcaat ctcaagagca gagaccgggt ccaaggccga 1198321 tgtgatttcg tccaacaata gaatggagga aggatttgag agcgttctgg ccagtgacag 1198381 tctttgccgc tgcccgcccg ataagtctct ggcgcttctg tctaacaact ctggcggcag 1198441 ccctgcaagc gaagccagct tttcaggaga gtacagctgg gattgatgca gcctttgtac 1198501 aagacttaaa ttgtcacgca ctgtcccgtc gagcacggga gccgattgaa acgcgagggc 1198561 tgccgttcgc ctcagctcat tgacattcca ttctctgact tcctttccgt atatgttgac 1198621 ttcgccgctg tcaggcgttc tcattaaatt acacatagaa aggagggtgc ttttgcctga 1198681 gccggaaggg cctaaaacgg ctacgattgc accctgttga atgtctccgg tgacatcctg 1198741 cagcacatca taggtttgtc catcttgttt atagcttttt ctgactgatc tgaaggagat 1198801 ggctggtatg ttttgtgttt gatcgtttgc ttccattaca ataatcacct ttcaatataa 1198861 gtaggctgac attatattta actataacgt gaaacagatt ccttttggta gcacaaataa 1198921 aggagaacag gctttcaccc attctcctgc agatgctacg cagtcagatt tgactgtgct 1198981 ttctttttcg gttttctcgg ctgtgaagcg aaggtatgta acatcatccc cgctattata 1199041 atgaacaaac cggcaaatga taatagagat gggaaaacgc ctgacagcag aacaatttca 1199101 ccaagcagcg cgaaaatcac ttcaccggat tgagtggctt caacagctgc gagtttttgc 1199161 ggattgtctc ttaccatatc agtggcccag aaaaataaaa ccgtcgcaat gatgcctgag 1199221 ctgacggcaa cgataaagga ttgaacggtt tgacttgctg ttggaaggcc atctgaccac 1199281 cagccgtaag ctgctaatat aagccagaat ggaaggcttg ccaatgtcat tccaagcacg 1199341 cgctgaaatg tatcaagccg gcctccgtat tcttcgagca ttcttcggtt tcctaacgga 1199401 taggcaaaag ccgcaatgac aaccggcagc acactgaaaa gcagcatcct cccagaaagc 1199461 gattctgcat gctgaagctg aatcagagcc gctccaatca ggatgatcac agaagtgcca 1199521 agtgaaacca ggggaatctt ttggcgaatg agctgcggac cgcccggcat atcttgtttg 1199581 acataaaaca aaggagataa gagcaccccg gctacaattg taatttgcca ggttccagct 1199641 atgagccacc ccggaccgta tgcagccgca aatgtaatcg gtgcgtaaaa aagcacgaaa 1199701 ccgacgaagc tccatttgat ccaataaaac ggctttttcc tcatttctag taagagaggc 1199761 gtgaatgtcc ctctcatgat gacaatcaaa cataaaaatg gcaccataaa aataaagcgc 1199821 agcgaagagc tccaaagcca gctgcctcct gataactcca tcgctctgtt taatataaag 1199881 gtaacggcga aaaagagtga agccaatatt ccgataacga tagctttcat gatatccctc 1199941 attctggcat tattttttta tactatacta ttcggtatca tgcagatcaa tggaatcatg 1200001 agaaaaacat catgtttggc gaaccgctat atgtggaaga caaaaaaggg aggtgaaatt 1200061 gatggaaaga gagacacaga catacttctt tccggatgac ggcaggattc cgaatcaccc 1200121 tgattttccg ctcgtggtgt atcaaaacgc gcttaaggac accggactgg cagagcggat 1200181 cgtcacccgg catggctggt caaacagctg gtcagggagt gtttttccat accatcatta 1200241 tcacagcaat acgcatgaag tcctgattgc ccttaggaga gaggctgtga ttcagtttgg 1200301 gggagaaaaa ggggctgcca tccctttcaa atcaggcgac gcagtcgtga ttccagccgg 1200361 agtcggacat aaaaagctca gctcaagccc cgattttact gtccttggcg cctatcccgg 1200421 tggcgttcag tacgatatga agacggggaa gccgaatgag cgggaggaag cggtcaaaca 1200481 gattaagcag gcggcgttgc cggcgaatga tccgatcaca ggaaaaagag agcctctatt 1200541 ggaaatatgg gtaaagtgaa ggggagaaat tgctggattg tcaataacta gtgccgcaga 1200601 aacgatatga catgagctcc atataaatta atttcataat cgaagcaatt cacgttcaaa 1200661 ttttgttcaa aaagtgttat catatagaag gtaatcgaat tggagttttt tgtgtttgct 1200721 attttcagag agagtaaagg attttgactt attcaattgt ttatttttag ataaaaataa 1200781 tactgaatat ggcaagatga aaaactgggt agtaaacatt tatttttgta aatgattgtg 1200841 catgaattca caatccttat tcttatgcct taaaagcgtg agacagggag aggcactacc 1200901 ctttccaaaa aaatcagcaa actgcttata gtaaaggaga attggatatg ccagaaacaa 1200961 tcgatcaaac aaatgcgtct gtcagccaaa gccagcaaga tcttattgat cagctattaa 1201021 agccagaagt tcaagaatca ttgactgttt tagttgacca gcttccgaag ctgactgagt 1201081 tagtgaatat tttaacgaag tcttatgatt tcgctcagtc tgtagcgact gacgaagtgt 1201141 taaagagcga cacagtcggt gcgatcactg aaattctcga gcctgtaaaa gaaacagcga 1201201 aagaagtagc tgcgactgcg atcgaagcaa aagaccgcgc ggaagcaagc aacgaaacaa 1201261 ttggactttt cggccttctt cgcatgctga aagatcctca agctcaaaag ctgttccgtt 1201321 ttgctaacag ctaccttgaa gtcatgaacg aacgcgaaaa ccaaaaataa tctcagattc 1201381 aaattgatat aaaggacgga ggatatacga tgtcaaaaca tattgtcatt ctaggcgctg 1201441 gttatggcgg agttctttct gctctaacag ttcgcaaaca ttacacaaaa gaacaagcac 1201501 gcgtgacagt ggtaaacaaa tacccaactc accaaatcat tacggaatta caccgccttg 1201561 ctgcaggcaa cgtgtctgaa aaagcggttg caatgccatt agaaaaactt ttcaaaggca 1201621 aagacattga tcttaaaatt gcggaagtaa gctctttctc tgttgataaa aaagaagttg 1201681 cgcttgctga cggttctaca ttaacttacg atgcgcttgt tgtaggtctt ggttctgtaa 1201741 cggcttactt cggcatccca ggtcttgaag aaaacagcat ggtattgaaa tctgctgccg 1201801 atgcgaacaa agtcttccaa catgttgaag atcgtgtgcg cgagtactct aaaacgaaaa 1201861 acgaagcaga tgcaacaatc cttatcggcg gaggcggctt aacaggtgtt gagcttgttg 1201921 gtgagcttgc tgacatcatg ccgaaccttg cgaaaaaata cggcgtagac cataaagaaa 1201981 tcaaattgaa acttgttgaa gcaggtccga agatccttcc tgttcttccg gatgatctta 1202041 tcgagcgtgc gactgcaagc cttgaaaaac gcggcgttga gttcttaaca ggtcttcctg 1202101 ttacaaatgt agaaggaaac gtaatcgatc tgaaagacgg atctaaagtt gttgccaaca 1202161 catttgtttg gactggcggc gtacaaggta acccattagt cggtgaatca ggcctagaag 1202221 tgaaccgcgg acgcgcgact gtaaatgact tcctgcaatc tacatctcat gaagatgtat 1202281 tcgttgctgg agacagcgca gtttacttcg gtccagacgg ccgtccatac ccgccaactg 1202341 cacaaatcgc atggcaaatg ggtgagctga tcggttacaa cctattcgct tacctagaag 1202401 gcaaaacgct tgaaacattc aagccagtaa actctggtac acttgcaagc cttggacgca 1202461 aagacgcggt tgccatcatt ggtgctaatt ctacaccgct taaaggtctt cctgcttcct 1202521 tgatgaaaga agcaagtaat gtacgatatt tgacacatat taaaggactt ttcagcctgg 1202581 cttactaatc cttttaatga atctggcatt gccaaaagca ttcctttccg agtgctttct 1202641 ggcaatgtct ttttttatgt ttatgacagc gttaacattt cattttcaaa aaagagattg 1202701 atcccaaagg aatataaagg taaaataaaa acaaatcaaa atgttaacgt taacattttg 1202761 aaatagaatg aaagacggtg aggacatgga acccttcatg ggcaaaaact ttttattgaa 1202821 aaatgaaacc gctgtcagcc tctatcacaa ttatgcgaaa gacatgccaa ttattgatta 1202881 ccactgccac ttaagtccga aagaaatcta tgaaaataag acatttcaaa acatcacgga 1202941 agcctggctg tatggtgacc attataaatg gcgcatcatg agagccaatg gaattgagga 1203001 gacatacatt accggagatg cgcctgatga ggagaaattt atggcttggg cgaaaaccgt 1203061 gccgatggcg attggcaacc cgctctacaa ctggactcac ttagaattgc agcgtttttt 1203121 tggcatttac gagattttaa acgagaagtc cgggtcggct atatggaaac agacaaataa 1203181 actgctcaaa ggggaaggct tcggggcaag ggatttaatc gtgaaatcaa atgtaaaggt 1203241 cgtgtgcacc acagatgacc ctgttgattc tcttgaatac catttattgt taaaagaaga 1203301 caaagacttt cctgtcagtg tgctgcctgg atttcggccg gataaaggac ttgagatcaa 1203361 tcgtgaaggc tttcctgagt gggtgcaggc gcttgaagat gccgctgcca tatcgattac 1203421 aacctatgat gagtttttaa aggcgttgga aaaacgagtg cgattcttcc actcagccgg 1203481 cggcagagtt tctgatcacg cgatagatac aatggtattt gccgaaacaa caaaagaaga 1203541 agctggacgg attttttctg acagattaca aggaacagag gtttcttgtg aagatgagaa 1203601 gaaatttaag acatatacgc ttcagtttct ttgcggtttg tatgcggagc tcgattgggc 1203661 gatgcagttt catatcaacg ctttaagaaa cacgaataca aaaatgatga aaaggctcgg 1203721 acctgataca gggtatgatt caatgaacga tgaagaaatt gctaagcctt tatacaagct 1203781 gctgaactca gttgagatga agaaccagct gccgaaaacg attttatatt cactgaatcc 1203841 aaatgataac tatgtcatcg ccagcatgat caacagtttt caggacggta ttaccccggg 1203901 aaaaatacaa ttcggcacag cctggtggtt taacgatact aaagacggaa tgctcgacca 1203961 aatgaaagcg ttatcaaatg ttggcctttt cagccgtttt atcggcatgc tcaccgattc 1204021 cagaagcttt ctttcgtata cgcgccacga atatttcagg cggatcgtct gcaatttgat 1204081 tggagaatgg gtggaaaacg gcgaagtgcc gcgcgatatg gagcttctgg gaagcatcgt 1204141 tcaggggatt tgctatgaca atgcgaaaca ctactttcaa tttcaagaag agaaagcaaa 1204201 cgtgtaacaa agtgtccgct cagtatcgct gagcggatca ctatccgaaa attcttaaga 1204261 cacagaggtg gaacatgcga actgaactgg caaataaggt tgtgtcggtc gaaacggaaa 1204321 aaaggctttc attgaaagag aaaatgtcct atggctttgg tgattttggc aacggtttta 1204381 tgtttgatct cggccagatt tatttattga agtatttcac tgatgtagcg ggaatccccg 1204441 ctgcgatggc cggcggcatt tttttagtca gtaagctgtt tgcagcgata acagatccaa 1204501 ttgtcggctc atcaatcgat tatcgcaaaa acatcggcaa acgggggaaa ttcaggcctt 1204561 atctattaat cggcagcatc gtgcttgcgg tgcttactgt tcttattttt ctgtctccca 1204621 atgtatcaac gaccggaaaa ctgatatatg catatgcatc ctatatgatt tggggcatcg 1204681 gctattcgtt tgtgaatatt ccgtacggct cattaggggc agcgatgact caaaattctg 1204741 aggaccggac ctccatttcg acgttccgcc aaatcggatc acttggcgcc ttgtttatca 1204801 caagtgtggc cgtgatgccg ctgctcgtca agtttgataa tccgaaggtc ggctacccgg 1204861 tggtcatggg cttgttcgcc gcgctcggtg tgttttggtt ttatatttgc taccgcaact 1204921 gcaaagagcg cattatcata tcggaagcac ccaaagaaaa attaacactc tcatctgtcg 1204981 tcaaaacatt tattacaaat aaaccgctgt taacccttgt cctgatgacg attttttcaa 1205041 tttccgcata caacattaaa tccgccatgc tcgtctattt cgcacaatat aacttgggca 1205101 atgttgaatt aatggcttat atgaacttca tcattattgg ttcttccttt ttgggcgtcg 1205161 tattccttcc aaagctcgtc aagatgtttg gaaagaaacg aacggcaatg atcggctttg 1205221 gcatcagtgt ggccgcggat ctgatcaact ttatgcttcc atctaacgtt tatgtgttta 1205281 caattctcgc cagtatcgcc tttatcggaa tcagtatccc aaatggcatc acgtgggctc 1205341 ttgtctccga tattatcgac tatggcgaat ggaaatccgg tgaacggaag gaagcaacga 1205401 catattcact tttcaatttc tcaagaaagc ttgctcaatc tttgtctggc tttctctcgg 1205461 ggatcggttt ggggattatc ggctatgtgc cgaatgcagt ccagacagca caggcgctga 1205521 ttggcatcaa agcgctgctt cttctgtatc cggccattgc tttggcatta gcgatgttca 1205581 ttatcggctt tctttataaa ctcacagacc agcagcatgc tcagatcgtt caggatcttc 1205641 atcaaaagag ctgacaatat aatataaaga atatttaaaa taatttgtaa ataaaatgtg 1205701 tttgtagggg tttcgcttgg agagtgccca aaaaactgaa aaggaaggag gcacttgctt 1205761 gaaaacgata acaattgcag ctgaagaagc aaaggaactc gtttggcaaa agctggacgg 1205821 tgccggtttg aatgaacgag atgctgaaaa agtggcagat gttctcgtgc acgctgattt 1205881 gcgcaatgta cattcgcatg gcgtgctgca cacagaacac tatgtgaaca ggcttttagc 1205941 gggagggatc aatcctgggg cacagcctgt ttttaaagag acggggcctg tgaccggggt 1206001 gcttgacgga gacgatggtt tcggtcatgt gaattgcgac atggcgatgg accatgcaat 1206061 tgacatggcg aagaaaaaag gagtcggcat ggtcacggcc gtaaacagca gccattgcgg 1206121 agcgctaagc tattttgtgc aaaaagcggc tgacgaaaag ctgatcggaa tggcaatgac 1206181 gcatacagac agtatcgttg tcccatttgg ggggaggact cctattttag ggacaaatcc 1206241 gattgcttac ggagttccgg ctaagcataa aaaaccgttt atcctagata tggcgacatc 1206301 caaagtggct tttgggaaga ttctgcaggc ccgtgaagag ggcaaagaaa ttcctgaagg 1206361 atggggagtc gatgaaaacg gagaagcagt aactgatcct gacaaggtcg tctcactttc 1206421 aacattcggg ggcccgaaag gctatggact atcgattgta gtggatgtgt tttccggatt 1206481 gctggcgggc gcggcttttg gccctcatat tgccaaaatg tacaacggcc ttgatcaaaa 1206541 aagaaagctg gggcattacg tttgcgcgat caatccatcc ttttttactg actgggatac 1206601 gtttttagag cagatggatg ccatgattga tgaactgcag caatcaccgc cggctgttgg 1206661 attcgaaaga gtgtatgtgc ccggcgagat cgagcagctg catgaagaaa gaaataagaa 1206721 aaacggaatt tctatcgccc ggagcgtgta tgaattctta aaaagcaggt gagtaaaatg 1206781 aaagcggttc aagtgcgaaa agcgtatgat ctggtgacag cggaggtgaa gaagccagtt 1206841 ctttcaaagg atgatgaagt gctcgtgaaa gtcaagcgag tcggcatttg cggttcagac 1206901 atgcacattt atcatggaac gaatccgctc gctaccctcc cgagagtcat cggacacgag 1206961 gtaacgggac aagtggaggc agttggtgcg aatgtacaga gcctaaaacc cggtgatcat 1207021 gtggtgattg agccgatttc ttattgcgga tcgtgctatg cctgccgcaa agggcggccg 1207081 aatgtttgcg ccaagctttc tgtatttggc gtacatgagg acggaggcat gcgggaatat 1207141 attgtgcttc cggaaagaca gcttcacgcg gtctcaaagg acttgccttg ggaggaagca 1207201 gtcatggccg agccttatac gataggcgcc caggcagtgt ggagaggcca ggtggaaaaa 1207261 ggtgataccg tcctgatcca gggagcgggg cccatcggga tctgtgtgtt aaaaatggca 1207321 aaactggcgg gcgctgctgt catgatgact gacttgaaca acgagcggct ggcatttgcg 1207381 aaagaaaacg gcgccgatgc tgttgtaaat gtccaagcag aacatgttgc cgagcgggtc 1207441 cttgaatgga ctgggaatga aggagcaaac gtggtcattg atgctgtttg cctgccggag 1207501 acttttgcac tttcaattga ggctgtgtca ccggcgggac atgtggttgt gcttggattt 1207561 gatgaaagag cggctcagat ttctcagctg ccaattacaa aaaaagaagt cacgataacc 1207621 ggatcccgat tgcagaccaa tcagtttcca aaagtggtag agcttttgaa tggaggccgg 1207681 ttaatgcata acgggctggt gacccataca ttttcagttg atgacgttca tcatgcattt 1207741 cagtttatta aggagcatcc agatcaggtg cggaaagccg tcatcacgtt tgattaaatg 1207801 actgaatccg gaggtgcgag catgaatatg acattccgat ggtatggacg aggcaacgat 1207861 acagtcacac ttgaatacgt gaagcaaatt cccggtgtca aaggcatcgt ttgggctctc 1207921 catcaaaagc ccgtcggcga cgtgtgggaa aaagaagaaa tcagagccga aactgaatat 1207981 attcaatcct atggttttca tgctgaagtt gtagaaagcg tgaatgttca cgaagcgatt 1208041 aaacttggga acgaagaacg cggccggtat attgaaaact acaagcaaac gatccgcaac 1208101 cttgccggat ttggcgtgaa agtgatctgc tataatttta tgccggtttt tgattggaca 1208161 cgcacggaca tgttccggcc gctagaagat ggatcgaccg ctctgttttt tgaaaaggcc 1208221 aaggtggaaa gccttgatcc tcaagagctg attcggacgg tggaggaagc atccgacatg 1208281 acactgccgg ggtgggagcc cgaaaaattg gctcggatca aagagctttt tgctgcctac 1208341 agaacggtcg atgaagaaaa gctatgggac aatttatcat tctttttgca ggaaattctt 1208401 cctgttgctg aggcctatgg tgttcaaatg gccattcatc cggatgaccc gccgtggccg 1208461 attttcggac tgccgcgcat tatcacagga gaggcaagct ataagaaact gcgggcgata 1208521 tcagattcac cgtctaattg tatcaccctt tgtacaggtt caatgggagc caatcccgct 1208581 aacgacatgg tggagatcgc taaaacgtat gccggcatcg ctccattttc acatattcgc 1208641 aatgtgaaaa tttatgagaa tggcgatttt attgaaacat ctcatttaac aaaggatggt 1208701 tcgatcaaca ttcaaggcgt gatggaagaa ctgcataagc aggattacga aggatatgtc 1208761 agaccggatc atgggcgcca tctttggggc gagcaatgcc gcccgggata tggcttatac 1208821 gatcgggcac ttggcatcat gtatttgaac gggctgtggg acgcttatga agcaatggca 1208881 aaaaaagagg tgggcatatg atcccgctgc atgagaacct ggctggtaaa acggctgtca 1208941 tcactggcgg cagcggcgtg ctttgctctg cgatggcccg ggagctagcc cgtcatggca 1209001 tgaaggtggc gattttgaat cggacggctg aaaaaggcca agcggtcgtg aaggagataa 1209061 cggcggctgg cggcacagcg tgcgctgttg ctgcggatgt gctggacagg atgtcactgg 1209121 agcgggcaaa ggaagacatc cttggccaat ttggcgctgt tgatctgtta attaacgggg 1209181 ctggcggcaa tcatcctgac gcgataaccg atgtggagac atatgaagaa gcgggagaag 1209241 gccaatcctt ttttgatatg gatgagaggg gctttctaac tgtattctcc accaacttca 1209301 ccggtgcgtt tctggcctcg caagtgtttg gtaaagaact gctgaaggcg gattcacccg 1209361 cgatcatcaa cctttcttcc atgagtgctt attcacctat gacgaaggtt ccggcataca 1209421 gtgctgcgaa agcatccatc aataatttta cgatgtggat ggctgttcat tttgccgaaa 1209481 ccgggctgcg ggtcaatgcg attgccccag gcttctttct gacaaaacaa aatcatgatc 1209541 tgctgatcaa ccaagacgga acgttcacca gccgatctca caaaattatt gcgggaacac 1209601 cgatgaagcg cttcggaaaa ccggaggatt tgctcggtac gctcctttgg ctggcggatg 1209661 aatcctattc cggttttgtc actgggatca ccgttcctgt cgatggagga tttatggctt 1209721 attcaggtgt gtaacgaaag cggtgcaaca gaaactgaac caacataggg gtgaggttga 1209781 gatgttttca aaagataagc ttcccgttat cctttttttg ttcctggcag gggtgattaa 1209841 ttacctggat cgctcggcgc tttccattgc agctcctttt attcaggatg atctcacatt 1209901 gtctgccaca caaatgggct tgattttcag cagtttttcg ataggttatg ccatttttaa 1209961 ttttcttggg ggcgtggcat ccgaccgcta tggggcaaag ctgaccttgt ttgtcgcgat 1210021 ggttgtttgg tcgctgttta gcggagcagt cgccctcgct tttggctttg tcagcctgct 1210081 gattatacgc attctcttcg gaatgggaga aggcccgctt tcggcgacca tcaacaagat 1210141 ggtgaacaac tggttcccgc cgacccagcg ggcgtccgtt atcggtgtaa ccaacagcgg 1210201 cacgcccctc gggggagcca tttccggccc gatagtcggc atgatcgcag tggcgttcag 1210261 ctggaaggta tccttcgttc tcattatgat tattggattg atatgggcag tgctctggtt 1210321 caagtttgtc aaagaaaagc cgcaagagac gatcaaggaa gcaccggcaa taaaagcaga 1210381 aacgtctccc ggagaaaaaa ttccgctcac cttttacctg aagcaaaaaa cagtcctgtt 1210441 cacggcgttc gcttttttcg cttacaacta catcctcttc ttctttttga catggtttcc 1210501 gagctatctt gtcgacgagc ggggattaag tgttgaatcg atgagtgtca tcacggtcat 1210561 accgtggatt ttaggattta tcgggctggc tgcgggggga tttgtttctg actatgtgta 1210621 caaaaaaacg gcccgaaaag gtgtgctgtt ctcgcgcaag gttgtgcttg tcacgtgttt 1210681 gttttcatca gctgtcctga ttggttttgc cgggcttgtg gcaacgactg cgggggctgt 1210741 cactcttgtc gctctgtcag tgttctttct ttatttgacc ggtgctatct attgggctgt 1210801 cattcaagat gtggttgatc aaaacaatgt cggttctgtt ggcggcttca tgcatttcct 1210861 cgccaacacg gcaggaatta tcggcccggc tttaaccgga tttattgttg accaaacagg 1210921 cacgttttct ggagcatttt tgcttgccgg tgggctggct gtcttcgctt cacttgctgt 1210981 gattcgtttt gtccgtccaa tcattggtaa gccagcggga acagaagctg agaatcctgt 1211041 gtcttattaa tctggaaata tagtgggaga ggcggtatgt ttgatgatac aatatacagt 1211101 aaataatcgc agccggtatg ataaggaagg gaattagatg gtaaccataa aagatatcgc 1211161 aaaactcgca aacgtatccc acactactgt ttccagagca ctcaacaaca gcccttacat 1211221 caaagaacat acgaagaaaa aaatattaga gctagcagag cagctcaact atacaccaaa 1211281 tgtaaatgcg aaaagtctgg cgatgcaaaa gtcgcatacg atcgggctat tctttacaag 1211341 cattacaaac ggaacctcac acagcttctt tgcagacact atcaaaggcg tcaatcaagc 1211401 cataagtgag gattacaatc tgtatgtgcg cggcattgat gatctgaaaa actatgactc 1211461 cgttacaccg atgagatatg acggcatcat tttaatgagc caaagtgaca ttgataattc 1211521 ttttatttac catattcgcg aaaaaaacat tccgcttgtc gtgctgaatc gtgatattga 1211581 tgatcgtacc atcacgaata ttttgtccaa tgacaaggaa ggctctcaag aagctgtaga 1211641 atacttcatt cagtccggac atcaagacat cgccatcatc gaggggatcg aaggctttaa 1211701 atcctcccag cagcgaaagg aagggtactt atccgcactg attcaacatc atattccgat 1211761 caagcatgaa tacagtgtca aaggacagta cgatatggaa agcggctttc aagcgatgga 1211821 gcggctgctg gcactgccga atcctccaac cgctgttttt tgttcgaatg atgacatggc 1211881 aatcggagcg atgaatgcga tattcgcaaa gggcctgcgc gttcctgatg atatttcggt 1211941 gatcgggttt gatgatattg ggttttcaca gtacatcacg ccaaggcttt caacagtaaa 1212001 gcgcccagtg gagaaaataa gcgtgctcgg tgcgcaaaaa ctcttgtcgc tgatcagcga 1212061 gcccgaaaca aaagcagaaa aaatcttgga aaacacagaa tttatggtgc gtgattcagt 1212121 cagacgattg acgacgtgat gtcccgtttt tcagcgggca ttctttatac agaaaaatgt 1212181 taacgtgtgc ataaagtgag agggaggcaa taagggtgca gaagctgaat aaaaatgtgt 1212241 acgatcacta tactcagtat ccagaaaaaa ttctccaatt cggagaagga aactttcttc 1212301 ggggatttat cgattggcag attgatcaat tgaatcaaca cactgatttt aatgggagcg 1212361 tggcagttgt ccagccaaga ggctcagaaa aaatcaaacg attaaatgag caagatggat 1212421 tatatacact ttttttacaa ggaatgaaag acggagaagc ggtaaacgag catatgatta 1212481 tcaactcaat cagccgggga attgacctgt tttctgatta tgaagcatac aaagaattgg 1212541 catcaagcga aaggcttcgg tttattatct ccaacaccac tgaggctggg attgtatgtg 1212601 atgaaaaaga tcgtttagag gataggccgc aaaaaacatt ccctgggaaa ttaactgcat 1212661 ttctttactt tcgctatcag gcttttaaag gagatcagac aaaagggtgt gtcctgatcc 1212721 catgtgaact gatcgagaat aacggtgaaa agctgaggga aacggttctt cattatgcac 1212781 atctgtggaa gctggaggaa ggatttacac agtggattca tgaggccaat acattttgta 1212841 atagtttagt agaccggatt gttccgggtt ttcccgtcga cagcattgat gagatcacgg 1212901 cagatcttgg ctatcaggat gatttgatag ttgtgggaga gcaatattat ttgtgggtta 1212961 tcgaggggcc tgattggatt ggaaaagaac ttccctttgc ggctgcaggg ctgcatacaa 1213021 agatcgtcag cgacctcacc ccataccgga ctaaaaaagt aagaatttta aatggcgctc 1213081 atacagcaat gacgccagtg gctttattat acggcttgaa gactgttagg gatgcagtcg 1213141 agcatccgga agtggggcga tttataagag agctgattga tgacgaaatt cttcctgttt 1213201 taaaaatgga aggtctttct cagtatgctg acgatgtgct gaaccgtttt aaaaacccgt 1213261 atattaagca ttacctggaa agcattgcat tgaacgccat ttccaaattc aaaacgagaa 1213321 acctgccgac tcttaaggaa tatgctgaac aaaagggaca gcttcctgaa cgcttggtgt 1213381 tttctttcag cgctcttctg tatttttatc atgataacga gacattgcag gatgatccgg 1213441 cagttcttca atttttcaaa gaggtttggt gtcaggagga tggcgacatg cttcggattg 1213501 catcaagagt gttaggcgaa cagcggctgt ggggggcaga tctcaatgag ataccgaagc 1213561 tgactgatag agtcgctgtt tacttgaatc atattcatga gctgggcatg cagagggctc 1213621 ttgaacaata ctgcatacaa gggggagagg tacgttgaag tcgtttataa agattcataa 1213681 gcaagataat gtccttcttg ctctgcggga tattcaaaag ggagagaggc tgcatgctta 1213741 cggcgtgtcg attgaagtaa aggatgatat aaaaagaggc cataagattg cattgcagtc 1213801 tatcaaagaa aacgacagca tcgtcaagta cgggtttcca atcggtcatg catcacaaga 1213861 tatctcgatc ggagagcata ttcatgtcca taatacgaaa acaaacctgt ctgatatcca 1213921 attatacagc tatacaccga gatttgatga aaatccgtat tctaatgaga accggacgtt 1213981 taaaggtttt agaagagaaa acggagatgc gggtgtacgg aatgaattgt ggattgtccc 1214041 aactgtcggc tgtgtcaatg gaatagcaga aaaaatgctg cagcgttttg tcagagaaac 1214101 aggggatatc gctccatttg ataacgtact ggtgttaaag catcaatacg gatgctcgca 1214161 gcttggcgac gatcatgaaa atacgaagca gatcctgctg aatgccattc gccatccaaa 1214221 tgccggcggc gtcttggtgt tagggcttgg ctgtgaaaac aatgagctgg caagaatgaa 1214281 ggaagcactg caagatgtga acttgaagcg ggtgaagttt ctggaatccc agtcggtgac 1214341 cgacgaaatg gaggcaggcg ttgctttgct gaaggaaatt catgaagcgg ccaaaggaga 1214401 taagagagaa gacattccgc tgtctgaact gaagatcggg ctgaaatgcg gaggttcgga 1214461 cggtttttcc ggcataaccg caaacccgct gcttggacgt ttttcagatt atctcattgc 1214521 acagggaggg agtactgtgc tgacggaagt accggaaatg ttcggcgcag aaaccatcct 1214581 gatgcagcgg gctgccaatg aagaagtgtt tcataagata gtcgatttaa tcaatgattt 1214641 caaacaatac tttattaaac atgatcagcc ggtgtacgaa aatccttcac cgggcaacaa 1214701 agcgggcggc atttctacac ttgaggataa atcgctgggc tgtacgcaaa aagcggggat 1214761 ttctcctgtc acggatgtct tgaaatacgg tgaagtactc aagacaaaag ggctgactct 1214821 tttgagcgca ccgggcaatg atttgatcgc ctcctccgca ttggcggctg ccggctgcca 1214881 aattgtcctc tttacaacgg gaagaggcac gccgtttggc acctttgtcc cgacggtgaa 1214941 agtagcgaca aacaccgagc tgtatgaggc gaagccgcat tggattgatt ttaacgcagg 1215001 ccttttagca gaggatgatg ttcatgagga atatgtgctg cgtgagttta tccactatat 1215061 gattgaggtg gcaagcggcc agcttgtgaa ccatgaaaaa aatgatttca aagaactcgc 1215121 catttttaaa tcgggtgtga cgttataata agaaaaggct atccttcaag cggatagcct 1215181 tcttcattaa atcaatttta aaccgctgac taaaataatg gaagccataa taaattgcag 1215241 tggacgcggg gagaatcgag gcgaaagatg gctcccgatc agtacgccgg gaattgaacc 1215301 gaggagcaga ttagctgcca gcatgtaatc cacgcttccg aagcttgcgt tcaaaatgcc 1215361 tgctgccgta acaagaagaa aagcatgcgc gatatcggtt ccgacaatct gtgacgcttt 1215421 catgttaaat aagtaaatca tggcgattgc aaataatgag ccggacccga ttgatgttaa 1215481 tccgacgata aacccaaaca caacaccaat aagaattgtc agcgccctct tattttcaag 1215541 cggcatcagc tgccagcggt tggggcgaag ttttctatcc aaaaacaaac gaacgatgat 1215601 tgaaatggca accagcgtta acacatatcc tagagcgtgc ttaataattt cttcctgatg 1215661 ctggtgaaag gcggggaaca aatgcaatat gccaatggct agcgaagcac tcggaatacc 1215721 gccgatggct aagtatttta ccaatttaaa gttaatcgtt ttctgccgcc aatgggaggc 1215781 aacgccaaac agctttgtga tcgagttata tacaagatcc gtaccgaccg cgatggaagg 1215841 attaattcca agcacaatta aaaggggagt taataaggcc gctccaccca ctcccgtcaa 1215901 tccgactaag gctccgacaa acaaacccat caatatgatg cttacactca tgataaaggc 1215961 ctcctgaaaa cccgactaga attcacccga atcttattcg cgttggtcaa gtattaattg 1216021 taagtgctcc atcggctgct gaaaaacccg agctctatcc gctccctgat ggtatcattc 1216081 aattgacaac accttataca tcaggagaac acgtctttca ggtgcaacga gcacttgcgg 1216141 ctctgtattt ttaccctgat aaaggcgctg ttaacaacgg aattgacggc gtttacggac 1216201 cgaaaacagc tgacgcagtt gcccgttttc agtctgttaa cggtctaact gctgacggta 1216261 tctacgggcc tgcgacgaaa gagaagatcg cagcgcaatt aagctgatca aagaccataa 1216321 aaatcccgga gccgctccgg gatttatttt ttcttcttca acttttttat aattccagca 1216381 ctgcgctccc tcacccgaag cgagtacccg gaaagcccaa accttccgta atcaacaaac 1216441 ttcacacgcc tcaccaattt tttcactgta tcacctgaca ttatcctctg tttgtattta 1216501 ttatatgtca ccctttaaga aaaggaataa ggacaagagc tgttttccct tgtcctttta 1216561 gtgtgatcat gctttttttc gtttatactc gtcaatcagc cgttcgtttt ctttgaagat 1216621 tcttgctgta tgcggactga cttgatagct tgcgacactg gtggttgaac gttttttcag 1216681 gattttaaac ggcttcgccg ctctgggctc gcatctgttt tgaaacgcac gttccattat 1216741 ccttcacctt cctcctcaat tggcagcacc aaatcatata tgctcgttaa tgacgtaaat 1216801 agcaaataat caaattccgt gacaatgctg tcagacgtca gcttgatgac atagttctgt 1216861 gtctcgatgg taaaagggat gagaaccact tttccgtatt ggtcgtaata aacatccttt 1216921 cgatcgagcc gtgtttgtac atctgccgga tcatccatat gctcggttaa ccggtcttta 1216981 tcagcctgtg tcgaatagtg gcaaagagaa gccgttaagt tcattttatc agcataggtt 1217041 ttcagcagct tatcaatacc ttcagcataa gcatctatac ttccataata aacatggatc 1217101 ggttcgtttt tcaataggta ttggtatgtt ttcagccgat tgagatacat gtggagcatt 1217161 tcgttgtttt cttcaagaat ttctcttgtg tctgtttcaa gctcgctgcc ggccagtttt 1217221 ttgacatatg cacttaagaa gataaaagca tcaatcaaag caaaactgac tgcgacaatg 1217281 agataccgtt cccagtgggt aaatagggaa gtgggctcat atgtccagta taccatagcg 1217341 cccagaacaa acagcaaata ccaagttttc cgaatggcgg acattttttc tttgaccttc 1217401 gcttcgaaac gccacgtggc atacacgtat aaccccagtc cggccacgat gcaccagacc 1217461 atgatctgaa agaataaaac catattcgaa tccctcacat ctgaaatagg ttctgcttat 1217521 tgtattcgag agatccggat ggttttcctg ttccatcaaa aaaaccgctc ctttgacaga 1217581 agcggtgtga cattaaaata tcatatttaa aataaagtag gcgatggcac caagtgtcgc 1217641 tgaaatcgga agcgtgatga cccatgtaat gagcattcgc ttggccgtac cccagtttac 1217701 gccttttacg cggtgggacg caccgacgcc aagaattgat gaagaaatga cgtgggttgt 1217761 actgaccggc aaatgaataa acgtggcgcc gaaaataatg gctgctccgg ttaagtcagc 1217821 ggaaacaccg tttaccggac ggattttcat gatctttccg ccaacggttt tgatgatttt 1217881 ccagccgccg attgatgttc cgagacccat ggctgtcgcg caggcgaatt gcacccaggt 1217941 aggaatatca ttagcagaag tatgtaaatt cgctgtgatg agagccattg tgataattcc 1218001 cattgctttt tgcgcatcgt ttgttccgtg tgtatacgat tgcagggcag ctgttacaat 1218061 ctgcactctg cggaattgct tattcgtttt cgccaagttg ctgtctttga aaatcagctt 1218121 aacgatgcta taaagaataa aaccaaggac aaaggcaata attggtgata gaatcagtgc 1218181 ttcaatgatt ttaatgaagc ccttatagtt taacgctgca aatccggctg ccgcaatggc 1218241 tgcaccggca atagcgccga tgatggcatg ggatgagctg cttgggatac cgtagtacca 1218301 tgtgataagg ttccaggcaa ttgcagcgag tagcgcagcc aaaatgacaa cagagccatt 1218361 ttccagcgta taaggatcta cgatgtcttt cgtaatggtt ttggcaacac ctgtaaacgt 1218421 cattgctccg acaaagttca tcacagcagc caatataatg gcatggcgcg gttttaacgc 1218481 ttttgttgat accgaagtcg caattgcgtt tgccgtatca tgaaacccgt tgatgaaatc 1218541 aaacgccaga gcacaaatga ctattagtat cgttaatatt aatagaatat ccatttttac 1218601 ccctcgttac gcgtttttca taatgatggt ttcaagatta ttggcaacac tttgacaaga 1218661 gtcggcgatt tcttcaagcg tttcgtatat ttcacgatat tgaatgactt tgattggatc 1218721 tgtttcattt ccgaaaagat tctttaatga ttttctgtgc aagttgtcac aactgtgctc 1218781 atactcttta attttgattg cgtgaggctg aatatccttt aagcgatttt ctgccagcag 1218841 ctcgatcgta atcaaaatct ctttcgcaca ttctctgata tatccgctga atttatcaat 1218901 atgctcgtct gatgaagtaa ttgagaaaat ctccatcatg gcagagaaat gttcgattcc 1218961 gtcaagcaca tcatccaagc tgtttgtcag ctgaaggata tcttcgcgct caataggagt 1219021 gatgaacgct ttgttaagct ctttaatcat gacatgaaca tgattgtcac cttttgtttc 1219081 atattccttt aacgtatctg caaattcttt aagagtcgtt tggttagtga ccttaaaatt 1219141 cacaaaatat tctgcagttt cgtctatgtt ctttgcaatt tctgttaaaa ggagtgagaa 1219201 cttatctttt tttcttctta tcattaaaaa ccctccatag tttgaatgaa caatgcacac 1219261 atcaaattat tatatagcct tttgtcgaaa aaaaacaggt aaagtcgaaa aaaacgtatc 1219321 ttgacttttt tgataaatcg tgtctcctta ttttgaccta cttcgcttta aaaaaacgac 1219381 ccaagtttgc aaaaactttc tgcttaacgt aaaaagtata tcaaaagttg tgtttttcct 1219441 gtcaactttt atcttctgtt tcaccaaaaa acggttccct aaacaaggga accgttttat 1219501 cagcttgctt ttcgtttttt catcccgtaa taaacaggca gtccggcaag gccgatgagg 1219561 atggataatc cgcagctcat tgtatctgta atgagtgtgc tgcctaacac aaagaaggag 1219621 cccgcgattg ccagaattgg cataaatgga taaagcggaa cactgtaggc gcgcttttct 1219681 ccctttgctc gcttgcggag aataaacact gcaaaaaagg ccatcacata aaaaatgtag 1219741 atcatgaaaa tggagatttc tgagagctta tcagggttgc tgatcagcat cataatcaaa 1219801 gccaaagcaa tttgaaaaga aatcgcaatc catggtgtgc ggaacgacgg gtgtacatgt 1219861 gacagttttt cagcaaatgg aagctgtttg cgttccgcca ttgcaaatga aacacgcggg 1219921 aaagaaagca cctttccatt taagcaccca aagatgctga cgataatccc tacactgatc 1219981 agctttccgc caattgaacc gaacagcatg gttgcagcgg tgcttgtcgc attttcacca 1220041 agcgtgacaa tttcgttcgc tgacaggatg tgaagcaatg caaaattaat gaaaatatag 1220101 atcgccgtta caattaataa tccgcccgtc atagcgcgtg gcagcagctt ttcgggattt 1220161 ttcatttctc cgccgagagc ggcaaggaga atccatccgt cataagcaaa caacgtagct 1220221 aaaatagccg ccccgaagtt catatcagaa atgctttcgt ttactgctgt gaagatgtgc 1220281 tgatcgcctt tccaaaggcc aaagacgatg atgcaggcaa tcggaatcag ttttccgatc 1220341 gttgtcagcg tttggacaaa accgccgtat tttgtaccga taatattaat gacgcataaa 1220401 aagagaactg ctataattcc aatgactttt gatagtccag atccccagcc gaaaagattc 1220461 gccattaaag atccaaaata taaacccagc gcgccaataa tcgccgggcc gtaaatgata 1220521 atctgcaccc agccgcacaa aaatccccaa aactcgccgt acacttcttc aaggtacgta 1220581 taaagcccgc cggtttttgg aatctgcgtt ccgatttccg cgattgtcaa accgcccgcc 1220641 agtgttaaaa taccgcctaa cagccaggcg aaaagcgcca tttttgaatc acctgaataa 1220701 gcaagcacag cgccgggctt cataaaaaca ccagaaccga taatggttcc gatgacaaga 1220761 gtaagggcaa acaagaggcc tatctctttt ttcaaaccgt tgtcttcagt atgcatgtcc 1220821 ttaacctcct atgatgttga agcttcatgt tgaagaatct attttttcat attgtaaacc 1220881 ctattttaga aaagtgaaat aaaataaatt ttctgatttt cgaaatttgc tttgtgtaca 1220941 gcagataaaa ctgtagaaat acctgtttta atggtctata aacgaataaa attcataatt 1221001 tttatttaca aagttcgtgt tttatgtatt aggattttag ccggtacaga ggggagatga 1221061 gaattcagaa aatgaacgaa ccttcggtga agctgatatg ttgactttct catgcgaata 1221121 aaatactttg ttattagaac aataaatata caattatgat atgatatctc gaaatcgaga 1221181 taaaataacc tggagggaca gcatatgaaa gttaacggca ttcaccacgt atcggcatta 1221241 acggccgacg cacaaaaaaa cttggatttc tataagaaag tattaggatt aaagctcgtc 1221301 aaaaaatccg tcaatcagga tgaaccgaca atgtaccatc tgttctacgg agatgaagtg 1221361 gcaaacccgg gaactgagct gacgtttttc gagattcccc gcattgcacc gtttcatgcg 1221421 ggaacaaaca gtatttcttc tattggattg cgcgttccag gcacagaagc cctgcattac 1221481 tggaaagaac gttttgaaga gcagcaagta acgcacagcg gcatctccaa aagagccgga 1221541 cgtgacatat tggcatttca agatcatgag gggcagcgac ttgtgctgac tgctgatgag 1221601 gaaggaaaag gatatggcct gcctgttaaa cagagcggca ttccggaaga attttcgttt 1221661 cgcgggttag ggccggttga actgactgtg ccatatgctg aaccaacttt acacgtattg 1221721 acgaatattc ttggatttac agaaatcagc cgtgaaccag tcgaagggca aggaaccgcc 1221781 gttattctgg aatcaggaga aggcggtgct gcaacggaaa tccatttaat agaaagaaac 1221841 gatcttccgc gagagcgtca aggcaaaggg agtgttcacc acgtcgcatt tcgggtaaga 1221901 gatgaagaag aacttgccgg gtggcaccgg atcatcagcc gcgaaggctt tagcaattca 1221961 ggcatagttg agcgctacta tttcaaggcg ctgtatttca gagaaccgaa cggcattttg 1222021 ttcgagttat caacagacgg accgggcttt atggtagatg aaaatcttga tgagcttggc 1222081 caaacgattg ctcttccgcc atatctagag catcgaagag cagaaattga agcaaaattg 1222141 aaaccgatcc aataaattgt gattcttttg ccttccggcg ccgccggagg gcttttttta 1222201 ttaccataat taattttgac ctaaacagca tgccttatta gggaggaaat atcagatgct 1222261 gattgggaga aatggcttaa aaccctttgc aaatatgggt gattggtatg gaatggcctc 1222321 ggcaaaaata ttgtctttgt ttattaatag tttattcata tttgcttgtt acactatttc 1222381 aaagttagac aaaaaggagt gaaaaataag tggaaaagaa aaaacgcgag ctggatatcg 1222441 tcctcctcct cattttgctc gcatctgcat tcttaaatat ctataacatt tggaaggacg 1222501 acacggtgaa tccttattac accgcggcag ttacaagtat gatgcaaagc tttcataatt 1222561 tcttttatgc ttcgttcgat gctgccggct ttataacagt agataaaccg cctgttacat 1222621 accaaatcca aacgatcagc gcactgatat tcggtatgca cggctggagc gtcatcctgc 1222681 ctcaggcact tgctggtgta ggttctgtcc ttcttatgta cttgctgata aagccgacat 1222741 ttggaaaaac ggcggcgcgt attgcctcat ttgttatggc atgtacgccg atagctgtag 1222801 ctgtagcacg tacaaacaat gttgatgcat tactggtatt tttcttattg cttgctacat 1222861 ggcttctctt taaagcgatc agaaaaggaa agctgatctg gctgttagca gcatttttcg 1222921 ttgttggagt aggttttaat acaaaaatgc tgcaggctta catgatttta ccggctttct 1222981 tattgttcta tctgattgcg gcaaacgcca caatcaagaa aaaaatcgtt tcattggtaa 1223041 gtgcgttagc cgtattagca gccgtttcgt tatcgtggcc gctcattgtt gacaatatcc 1223101 ctgcaagcaa gcggccttat atcggaagca gccaaaccaa ctctgttttg gaattggctt 1223161 tcggctataa cggaatccag cggctgacag gccaaaattc aggcggcggc cagggtgcgc 1223221 caaacaaaga cgcttcaaaa gaaatgtctt cttctgataa cactcaagca ccgcctaatc 1223281 agtcatcaag caacagctca tcaagcgatg gtaaatcctc aaatggcaat atggcggcgc 1223341 ctccatccaa tggccaaatg ccaagcggcg gtcaaggagg ccctccaagc ggcggagatg 1223401 gcggccaagg cggacccggc ggagacggag ggaaaggcgg tacaggaacc ggttcgaaaa 1223461 tgcaatcagg ttcagggatg tttggaacgg gaacacctgg tccactgcgg cttttccaac 1223521 aagagttatc tgatcaaatc agctggcttc tgccatttgc gatatttgga atcgcaggct 1223581 tactgatcgc tggcgcaaga gaaagaagaa gattatctgt agagcagaag gaaacggtgt 1223641 tctgggttgc gtggcttgta ccgattgccg gattcttcag tgtcgcagaa tttttccatc 1223701 attattatct catcatgctg gcaccgccga ttgcggctct tgtcggtgcg gggtgggtcg 1223761 ctcttgttca tctgtaccgc aatcagacag gctggaaagc atggcttttg ccgggagcaa 1223821 ttattgcgac aactggattt gaattgttta ttctcagaaa ctacaacgat caaatcggtg 1223881 ttggatggag tatcggggta ggtgttatcg gcgtgttgtc agcgattgct ttgctgctgt 1223941 ttaaacagcg ccaaaaaccg ttcagttatt atgtttcact tgcagctctc ctcgcattgc 1224001 tggtgatgcc gatgtattgg gcaagtacac cgcttctgta cggaggcaac agctcactgc 1224061 ctgaaacagg ccctcaactc gcatcaatga gcggaaaagg catgggaatg tctgatgcga 1224121 ctgtaaatga aaaactgatc aaatatctag aggagaataa ctccggagct gaatacctat 1224181 tcgccacaac cgattcgaac acagcggcac catatatcat taaaacgaaa aaagctgtca 1224241 tggctattgg tggatacagc ggttctgacc cggcaatcac actgactcaa ttcaaaaaac 1224301 ttgtaaaaga aggaaaagtg aaatacttct tggcttctgg aatgggaaga ggcggaaaca 1224361 atgacattgt tgaatgggtt gagaaaaatg gaaaagaagt agcatcagaa aaatggcaat 1224421 caagttctga tcaaaaaaca gaaaatactg attcagctga tacatcaagc agcaaggctt 1224481 caggtgaaaa cggcaaaatg ggcggacctg gcggaatgaa tcagtcagca acattatacg 1224541 aactacatgc tgatgaatag gaggcaaaaa catgagcaga catattcaat attcaattgt 1224601 tgtacctgtg tataatgaag agcttgtcat tcatgaaacc tatcagcgct taaaagaggt 1224661 catggatcaa acgaaggaaa actacgagct gctttttgtc aacgatggca gcaaagaccg 1224721 cagtattgag attttaagag agcacagcct gatcgatccg agagtgaaaa ttattgattt 1224781 ttcaaggaat tttggacatc agatcgccat tacggcaggt atggattatg cacaggggaa 1224841 tgcaatcgtc gtcattgacg ccgatttgca ggaccctcct gaactgattt tagaaatgat 1224901 tgaaaagtgg aaggaaggct atgaagtcgt gtacgccgta cggactaaac gaaaagggga 1224961 aacctttttc aaaaaacaaa ccgcggctat gttttaccgg cttctcagcg gtatgacaga 1225021 tattgatatc ccgattgata cgggggattt tcgcctcatg gacagaaaag tctgtgatga 1225081 aatgaagaga ttaaaagaaa aaaatccatt tgtaagaggg ctagtcagct gggtgggttt 1225141 caaacagaca gcggtcgagt atgtacgtga tgaaaggctc gccggagaaa caaagtaccc 1225201 gctcaagaaa atgctgaagc tgtcaatgga cggcatcacg acattttcac ataaaccgct 1225261 gaagctggca agctatgcgg ggattttaat gtcaggtact ggatttctgt atatgtttat 1225321 cgtgctgtat ctgaagctat tcacagacag cacgattacc ggctggtcat cacttattgt 1225381 gatccagctc ctgttcagcg gcattgtcct tctgattttg ggcgtgattg gcgaatatat 1225441 cggcagaatc tacgatgaag ccaaagacag gccgctttac atcgtccaaa aatcgtatgg 1225501 aattgaaaat aaaagactct atagagacca gcatatgtca taacctcaaa ccccctgtcc 1225561 gtaatggaca gggggttttt atgctctgag cacgatctaa agcaaaagat gctgatagat 1225621 atatggaaat tgggtaaaga agagattgtg agcttgtact gcggttcagt catgctgaaa 1225681 taaaaacagc aaaacttaaa gatttcgtcc tcggctttgc tgcatgtcag ctgttatatt 1225741 ggggggcttt taagaaacgc atgattagag ccgtaccagt tatgtttaat agaatactcg 1225801 tacccaatac aattccccac gtcaacgtcg attcagagag aagaaagctc agcaaaagaa 1225861 aagccaatcc tgcgcagatc atacccagtc ccacggtttt catgttcatg cctcctagca 1225921 aacgatgttt ctagcatctg atgtgaatga tgtcaatctg tatgatatac ggatatctcg 1225981 tcagaaagtt tcatagaaca attaggtctt ttatctaata aaaagcctca gaccgctttt 1226041 acggcctgag gcattatgtc ttacgaagtt ttctcttctt tttgatccag tttaattttt 1226101 ttcgtcattt ctttgccgtt tcggagaatt ttcacttcaa cggtatcacc gatctttgcg 1226161 tctttatata agatattgcg caattcactg cctgtatcaa tttctttacc ttttaggccg 1226221 atgataatat cctccgcttt taatccggcc ttttcagcag gagagcctga agcgacctca 1226281 cggatgtaaa cgcctttatt cagctggctg ccgaacaggc cgagtgtgcc ttcttggtaa 1226341 ttttgcggca cttgctctag atcaagcatg ctgacaccga tatatggacg ttcaatttgt 1226401 cctttagaca gcaattcttc agcaatcggt tttacgtcat tgcttggaat ggcgaatccg 1226461 ataccctcaa catcatcctc actgattttc atactgttaa tgccgacaat tttgccgtct 1226521 gtatttaaca aaggaccgcc gctgttacct ggattaattg ctgcgtctgt ctgaatgacg 1226581 ttaatgctcg tttcgccggc tgatgtagac attgaaaccg ttctgtccac gccgcttaca 1226641 attccttgtg ttactgtgcg ggacaggtct tttccaagcg gatccccaat cgcaataacg 1226701 gtctcgcctg ttctaagatc agatgaatca ccgaagtttg ccacttttgt gacgtggtca 1226761 tcactgattt ggaggacggc taaatcagtt aacgagtcac tgcctaccag ctttgcagta 1226821 acctcagtgc cgtcatataa agataccttc agtgatgatg ccccttctac gacgtggtta 1226881 tttgtaatga tataagcctt gccattctct tttttgaaaa tgacacctga ccctgaaccg 1226941 ctttctgtat cttcgctgga atcagaagaa ctagagccga acaaagagct gtttgattgt 1227001 gcctgaagat ttgtaatacc gacaatcgct ggtgaaaggt cttctaccat atctgagatt 1227061 ttagaagagt cctcgctctt gaatgcagat gagctgcttg agcttttttt agattcagag 1227121 gaggtgcttg ttgctgtaac agattgcgtt tgctgctggc tggatgattg ttttgcagtg 1227181 tcctgagaat catggtcacc aagcggtgta aacgtgtaaa tgccaagagc aagactgccg 1227241 ccgatcactc cgccaagcaa cggtctgaac catccgaatc ctcgtttttt cttctcctga 1227301 tcatgaatga cattgcgggc cgagtaggag gcgctctgat cgttctcttt cgttaaaaag 1227361 acctcattct cattaccttt cgttctgttt tcatcacgat agttatccat catgttcact 1227421 ccgtttctct attttcacat gtctatttat attgataggt ttatgacttg agtttatcat 1227481 aaacaaaaac tgtgggataa aaatgaaaag attatgggaa attgtgaaaa agtgcggaaa 1227541 acggtacact tcatattgta tatgaaagga ctgagtcgat ggaacagatt ggattgattg 1227601 gatatggcag catggcggat atgatcgcta gacagctgtt gaaacatgaa caaataaaag 1227661 agaatgagct atttattgag acgagaacga agggggagcg gctgcgggca ctcatgtcag 1227721 attatccaaa cgtatcggct gatccgttgg agaattgggc aaatacgtgc caattgattt 1227781 tgatatgcgt cccgccactc catgtcatcg aaacaatgcg ccgtctgtac ccgtatgtga 1227841 acagaaatac tcacatcgta tccatagctg ccggtgtgcc gctgcgtctt ttggaggcag 1227901 aaacagaagc cggtatctca cgtgttattc ctgccattac gtccgaagca gaagccggca 1227961 tctcacttgt cgttcacagt gaagcactgg ctgcagagaa aaaagaacgt ctgaatgaat 1228021 tgttatcggt tttcagccgt gtacgggaaa tcaaagaatc gaatttagat gtggccagca 1228081 atttaacgag ctcggcaccg ggattcatag ctgcaatctt tgaagaactg gcactgtctg 1228141 ccgtcagaaa cagcagcctg tccaaagaag aagcctttga ttttctgatt cattcgctat 1228201 acggaactgg caagatgctg atcgaaaaaa atatgtcttt cgaggagacg ctggaacgtg 1228261 ttgcaaccaa aggcggaata acgggagagg gagctgaggt gatacacgcc tctgtgccgg 1228321 acgtttttga tgaggtattt gaaagaaccc tgagaaaata tgaactgctt acagaacagg 1228381 ttggtaaaca aacatgaatc cttgaaagag gattcttttt ttatcactga atgattgaga 1228441 tttttcccag ttatattgca tttttcctct ttttttaata taatttgtta gaatattcat 1228501 aatttagtaa aaaaggagga gcgttatgaa attgtacatg tcagtagata tggaaggtat 1228561 ttcgggtctt ccggacgata cctttgtgga ttccggcaag cggaattatg aacgcggacg 1228621 gcttatcatg actgaagaag caaactactg tattgctgaa gcgtttaaca gcgggtgtac 1228681 cgaggtgctg gtcaatgaca gtcattcgaa gatgaataat ctgatggttg aaaagcttca 1228741 ccctgaagca gacttgattt ctggtgacgt caaaccattt tcaatggtgg agggactgga 1228801 tgatacgttt agaggcgctt tgtttctcgg ttatcatgcg agagcctcga ctcctggtgt 1228861 catgtcacac agcatgattt tcggcgtccg tcatttttac ataaacgatc ggcctgtcgg 1228921 tgagcttgga ttaaatgcat acgttgccgg ttattatgat gtcccggtat taatggtagc 1228981 cggggatgac cgggcggcga aggaagcaga agagcttatc ccgaacgtga cgacagccgc 1229041 agtcaaacaa accatttcaa gatccgcagt gaagtgcttg tcgcctgcga aagccggacg 1229101 gctgttgaca gaaaaaaccg catttgccct gcaaaacaag gacaaagtca agccgctcac 1229161 accgcctgac aggccagttc tgagcattga attcgccaat tatggccaag cagaatgggc 1229221 gaatctgatg ccgggaacgg aaatcaagac gggaactaca accgttcaat ttcaggcgaa 1229281 ggacatgctt gaagcctatc aggcgatgct tgtcatgact gagcttgcga tgcggacatc 1229341 attctgctaa aggggtgttt taggctttgg cgcgatacat gataaagcgt ttttgggcaa 1229401 tggcagctac gattttggtg attaccaccc tgacttttgt tctcatgaag gtcattcccg 1229461 gatctccttt taacgaggag agaggcacaa atgaagccgt tcaaaaaaat ctcgaagcct 1229521 actatcactt agacgatcct ctcattttcc aatacatttt ctacttaaaa tccatcatta 1229581 cattcgattt cggaccttca attaaaaaac cgtcggacag cgtaaatgat atgctggaac 1229641 gcggatttcc cgtttccttt gagcttggga tgacagcgat tgtcattgct gtgatttctg 1229701 ggctggtgct gggcgtaatc gctgcactcc gccgcaatgg ctttttggac tacgccgcga 1229761 tgagtcttgc agtactcggc atctccatcc cgaattttat tctggcaaca ttgctcattc 1229821 agcaatttgc tgtcaatctc aaactatttc ccgctgcgac atggacgagc ccgattcata 1229881 tggtgcttcc gaccgcagcg cttgctgtag ggccaatggc gatcattgcc aggctgacac 1229941 ggtcgagcat ggtcgaagtt ctgacacagg attatatccg cacagcaaaa gcaaaagggc 1230001 tttctccgtt caaaattatc gtaaaacacg cactcagaaa tgcactcatg cccgtcatta 1230061 ccgtcctggg cacactcgtc gccagcatct taacaggaag ctttgtcatt gaaaaaatct 1230121 ttgccattcc gggaatggga aaatattttg ttgaaagcat taatcagcgg gactaccccg 1230181 tgattatggg aacgaccgtt ttttacagcg tcattctgat tatcatgctg tttttggtcg 1230241 atttggccta cggtctctta gacccgcgca ttaaactgca taagaaaggg tgaagcgtgt 1230301 gaatctccct gtacaaacgg atgaacgcca gccagaacag cacaatcagg tgcctgatga 1230361 gtggtttgtc ttgaatcagg aaaaaaatcg ggaagccgat tcggtcaagc ggccgagttt 1230421 gtcatacacg caggatgcct ggaggaggct gaaaaaaaat aaattagcga tggccggact 1230481 ctttattctt ttatttcttt ttgtcatggc agttatcggg ccctttttat cgccccatag 1230541 tgtcgtacgc caatcgctga cagaacaaaa tcttccgccc tcagccgatc attggttcgg 1230601 caccgatgaa ctcggccggg atgtgtttac ccgaacatgg tatggcgcga gaatctcgtt 1230661 gtttgtcggc gtgatggcag cactgattga ttttttgatc ggtgtcattt acggaggcgt 1230721 tgccggctat aaaggcggca ggattgacag cattatgatg cggattatcg aagtgctgta 1230781 cggactgccg tatctgcttg ttgtcatttt gctgatggtg ctcatgggac cgggactggg 1230841 cacgattatt gtggcgctga ctgtgaccgg gtgggtcggc atggcgagaa ttgtaagagg 1230901 ccaggtgctt cagattaaaa attatgaata tgtactcgcc tcgaaaacct ttggcgcgaa 1230961 aacctttcgc atcatccgga agaatttgct gccgaatact atgggagcga tcatcgtaca 1231021 aatgacatta accgtacctg ccgccatatt cgcagaatca tttttaagct ttctcggcct 1231081 gggcatacag gctccgtttg caagttgggg cgtgatggcg aatgacggcc tgcctacgat 1231141 tttatctggg cattggtggc gcctgttttt tccggccttt ttcatatctc tgacgatgta 1231201 cgcgtttaat gtgctggggg acggattgca ggatgcgctt gaccctaagc tgaggaggta 1231261 gctgtatgga aaaagttctg tcagtccaaa atctgcacgt gtcttttacg acttacggcg 1231321 ggacggttca ggcggtcaga ggggtgagct ttgatttgta taaaggagaa acctttgcga 1231381 tcgtcggcga atccggctgc ggcaaaagcg ttacctccca aagcatcatg ggcctgcttc 1231441 cgccttattc ggcgaaggtg acagacggca ggattctatt taaaaacaaa gacctttgcc 1231501 gtctctctga caaagaaatg agaggtataa ggggagccga catttctatg atttttcaag 1231561 acccgatgac ggcgttaaac cctacgctga ctgtcggcga ccagctgggg gaagcgctat 1231621 tgcgccacaa aaaaatgagc aaaaaagcgg cacggaaaga ggtgctttcc atgctgtcat 1231681 tggttggtat tccagatccc ggagagcgcc taaagcaata tccccaccaa ttcagcggcg 1231741 gtatgagaca gcggattgtc attgcgatgg cgctgatttg cgagcctgat atcttaattg 1231801 cggatgaacc gaccaccgcc ctggatgtaa ccattcaggc acagatttta gagctgttta 1231861 aagagattca gagaaaaacg gatgtgtctg tcattctgat tacgcacgat ttaggggttg 1231921 ttgcccaggt agctgacaga gtcgcagtca tgtatgccgg gaaaatggcg gaaatcggca 1231981 caagaaaaga tattttttat cagccgcagc acccatatac aaaaggcctg ctgggctctg 1232041 tcccgcggct ggatttaaat ggcgctgagc tgaccccgat tgacggaacg ccgccggatt 1232101 tattttcgcc tccgccgggc tgcccgtttg ccgcccgctg tccgaacagg atggttgtgt 1232161 gtgacagggt gtacccgggc cagacgatca gatctgactc gcacaccgtc aactgctggc 1232221 tgcaggatca acgagcagag catgcggtgc tgtcaggaga tgcgaaggat tgaacatgaa 1232281 aagggggaag aggatgaaac gagtgaaaaa gctatggggc atgggtcttg cattaggact 1232341 ttcgtttgcg ctgatggggt gcacagcaaa tgaacaggcc ggaaaagaag gcagtcatga 1232401 taaggcaaaa accagcggag aaaaggtgct gtatgtaaat aatgaaaatg aaccgacttc 1232461 attcgatccg ccgatcggct ttaataatgt gtcatggcag ccgttaaata acatcatgga 1232521 ggggctgacg cgtcttggca aagatcatga gcccgagccg gcaatggcgg agaaatggtc 1232581 tgtttcgaaa gataataaaa cttacacatt tacgattcgg gaaaatgcga aatggacaaa 1232641 cggagatcct gtaacagccg gagacttcga atacgcgtgg aagcggatgc ttgatccgaa 1232701 aaaaggcgct tcatcggcat tcctaggtta ttttattgaa ggcggcgaag catataacag 1232761 cgggaaaggg aaaaaagacg atgtgaaggt gacggcaaag gatgatcgaa cccttgaagt 1232821 tacactggaa gcaccgcaaa aatatttcct gagcgttgtg tccaatcccg cgtatttccc 1232881 ggtaaatgaa aaggtcgata aagacaatcc aaagtggttt gctgagtcgg atacatttgt 1232941 cggaaacggc ccgtttaagc tgacggaatg gaagcatgat gacagcatca caatggagaa 1233001 aagcgacacg tattgggata aggatacagt gaagcttgat aaggtgaaat gggcgatggt 1233061 cagtgacaga aatacagatt accagatgtt tcaatcaggg gaacttgata ccgcttatgt 1233121 ccctgctgag ctgagtgatc agctgcttga tcaggataac gtcaatattg ttgaccaggc 1233181 gggtctctat ttctatcgat ttaatgtcaa catggagccg ttccaaaatg aaaacatcag 1233241 aaaagccttt gcgatggctg tggatcaaga ggaaattgta aagtacgtca cgaaaaataa 1233301 tgaaaaaccg gcgcacgcct ttgtatcgcc tgggtttacg cagcctgacg gcaaagattt 1233361 ccgtgaagca ggcggagacc tgatcaagcc taacgaaagc aaagcgaagc agctgctcga 1233421 aaagggcatg aaggaagaaa actataataa gcttcctgcg atcacgctta cttacagcac 1233481 aaagccggag cataaaaaga ttgccgaagc tattcagcaa aaattgaaaa atagccttgg 1233541 agtcgatgtg aagctggcca atatggaatg gaacgtattt ttagaggatc aaaaagcgct 1233601 gaaattccaa ttctctcaaa gctcattttt gcctgattat gcagacccta tcagttttct 1233661 ggaagccttt caaacgggaa attcgatgaa ccgcacaggc tgggccaata aagaatacga 1233721 tcagctgatc aaacaggcga aaaacgaagc cgatgaaaaa acacggttct ctcttatgca 1233781 tcaagctgaa gagctgctca tcaatgaagc gccgatcatt ccggtttatt tttataatca 1233841 ggttcacctg caaaatgaac aagtaaaagg aattgtccgt caccctgtcg gctatatcga 1233901 tttaaaatgg gcagataaaa actgatggag gcgattgagg aaatactgct tctttatgcg 1233961 aaggagcggt attttttctc tttcttgcac gtatacgtag ggtgcagagc aaatgaaagg 1234021 agtgttttcg ttgaattaca agccgaaagc gttgaacaag ggtgatacag tcggagtgat 1234081 cgcgcccgca agtccgccgg atccaaaaaa gcttgacacc gcgcttttat ttttagaaga 1234141 gctcggtctt caggtgaagt tgggcaaggc gctgaaaaac cagcacggct atttagcggg 1234201 acaggatgat gagcggctgg cggatctcca tgagatgttc agagacgatg aggtaaaagc 1234261 agtgttgtgc gcatgcgggg gttttgggac aggacgtatc gccgcgggca ttgatttcag 1234321 cttgatccgc aaacacccta aaatcttttg gggatacagc gatattacgt ttttacatac 1234381 tgccattcat caaaacacag gtcttgtcac tttccatggc ccgatgctca gcacggatat 1234441 tggccttgac gacgttcacc cgctgacaaa agcgtcatat aagcagctct tccaggagac 1234501 ggaattcacc tatacagaag agctttctcc gctgaccgag cttgttcctg gaaaagcgga 1234561 aggcgagctt gtcgggggaa atctgtcttt gctgacgtct acactgggca cgccatttga 1234621 aattgatacg agaggaaagc ttctgtttat tgaagatatt gacgaggagc cttatcaaat 1234681 cgaccggatg ctgaatcagc tgaaaatggg ggggaagctg acggacgcgg cgggaattct 1234741 agtttgtgat tttcacaatt gtgtcccggt gaagcgagag aagtctctct cgcttgagca 1234801 ggtgctggaa gactatatta tttctgcggg caggcctgct ctgagaggat ttaaaatcgg 1234861 ccactgctcg ccaagtattg ccgttccgat cggtgcgaaa gctgctatga atacagcaga 1234921 aaaaacagcc gtaatagagg cgggcgtttc agaaggggcg ctgaagacat gaaaatcatt 1234981 cgaatcgaaa caagccgaat cgctgtcccg ctgacaaagc cgtttaaaac cgcacttcgc 1235041 actgtgtata cggctgaatc agtcatagta aggattactt atgacagcgg tgcagtcgga 1235101 tggggagaag cacccccgac gttagtgatt acaggagaca gcatggatag cattgaaagt 1235161 gccatccacc atgtgttgaa gccggcattg cttggaaaaa gcctggcggg ctatgaggcc 1235221 attctgcacg acatccagca tcttcttaca ggaaatatga gcgcgaaggc tgctgtagaa 1235281 atggctctat acgacggctg ggcgcagatg tgcgggctgc cgctttatca aatgcttggc 1235341 ggatatcgag atacgctgga aacagattat actgtcagtg tcaactcacc tgaagagatg 1235401 gcagctgatg ccgagaatta tctcaaacaa ggctttcaaa cgctgaaaat aaaggtcgga 1235461 aaagatgata ttgcaacaga tatcgcccgt atccaggaaa tcagaaaacg tgtcggatca 1235521 gctgtgaaac tgcgtttaga cgctaatcag gggtggaggc cgaaggaagc ggtaactgcc 1235581 attcggaaaa tggaggatgc gggcctaggc attgagcttg tcgagcagcc tgtccataaa 1235641 gatgatctcg ctgggcttaa aaaggtgaca gatgcaacag atacgccgat tatggctgat 1235701 gaaagtgttt ttacaccgcg ccaggcgttc gaagttctgc aaacccggag cgcagacttg 1235761 atcaatatta aattgatgaa agcgggcggc atcagcggag cagagaaaat taatgccatg 1235821 gcggaggcct gcggggtgga gtgtatggtc ggcagcatga tcgaaacgaa gctgggcatt 1235881 acggccgcgg cgcattttgc ggcaagcaag agaaacatca cacgctttga ttttgacgcg 1235941 ccgctgatgc tgaaaacaga tgtattcaat ggcggcataa catatagcgg cagcacgatt 1236001 tcgatgcctg gcaaaccggg cctcggaatc atcggggctg cgcttttgaa aggggaaaaa 1236061 gagcaatgat gcacactgtc atatcagcag tggccaacat ctggacagcg cctgattcac 1236121 ctcgtccgtc tgatcaattc atgcttcaac cgactgtaat gatcagagac tggctggagc 1236181 gcatgacgta tgatgaacgg cttggattat gtacagacaa tgtaatccaa actcaggttc 1236241 tctttggcga aaaggtactt gtgacggcgg aacaggggga atgggtttct gtgatcgtgc 1236301 ctagccagcc atcccgaaag gatccgcgcg gatacccggg ctggatgaaa aagtaccagc 1236361 tggaaaaaac aaagcccatc catacacaac acgatgtgat gatcagcaaa cctgctgcct 1236421 ttttgtacag aagcaatggg gaaaaggaga tcgaattaag ctttttgaca gttctgcccc 1236481 ttattgcaaa agaaaacgga tattttaagg tttcgaccgt ttttggggaa aggtttgtga 1236541 ggcaaagtga tgcagtgcct gtcagccaac agaaagggac tgctgaagac atcattcaaa 1236601 cgggtgcgtt ttttcttggc cttccctacc tgtggggagg gatcagcggg tttgggtttg 1236661 attgctccgg atttatgtac agtatattta aggcgaatgg atacagcatc ccccgtgatg 1236721 cgggagatca ggctaaggca gggaagggtg tcccgcttga tgatatgaaa gccggtgatc 1236781 tgctgttttt tgcttatgag gaaggaaaag gagcgattca tcacgtcggt ctgtatgtag 1236841 gcggcgggaa aatgcttcat tctccaaaga cagggaagtc aatcgaaatc ctcacattaa 1236901 cagagacaat ctatgaaaaa gaattatgtg cggtgcgccg ctgtttttca gaataaggag 1236961 ggagacaaat gaggcgactg cctttgttag aggtcagcca gctgaaaatg cattttgacg 1237021 cagggaaaaa gcggacagtc aaagctgtcg acggggtcac ctttcagatt cgtgaaggag 1237081 aaacgttcgg gctagtcggg gaatcagggt gcgggaaatc aaccttgggg agagtgctga 1237141 tgcgccttta tcagccgaca gaaggaagcg tgacataccg cggcacaaat cttcatgcac 1237201 taagtgaaaa agagcagttt gccttcaacc gcaaactgca gatgattttt caggaccctt 1237261 atgcttcact taacccgcgc atgaccgttc gagaaattat tttggagccg atggagattc 1237321 ataatctcta caatacccat aaagcacggc ttctcgtcgt ggacgagctg cttgaggcag 1237381 ttgggcttca ccccgatttt ggcagccgtt atccgcatga attcagcggc gggcaaaggc 1237441 agagaatcgg gattgcgaga gcactgtcgc tgaatcctga atttatcgtg gcggacgaac 1237501 cgatttctgc acttgatgtc tctgttcaag cgcaggtggt caacctgctg aagcggcttc 1237561 aaaaagagaa agggcttacg tttttattca ttgcccatga tctttcgatg gtgaagcata 1237621 tcagtgacag gatcggtgtt atgtacttag gacacatgat ggaaattaca gagagcggca 1237681 ccttgtatcg tgaaccgctc catccctata caaaggcgct tttgtcctcg attccgattc 1237741 cagatcctga attggaggac aagcgtgagc gtattctctt gaaaggggag ctgccgagcc 1237801 cggtcaatcc gccaagcggc tgcgtgtttc gtacccgctg tccggaggcg atgcctgaat 1237861 gtggagaatc tcgtccccag cttcaagaaa tcgaacccgg ccgttttgtc gcttgccatt 1237921 tgtatcgaaa tgctgaaacg aaggaaaaag taagataaat aaaaagagtg gctccttttt 1237981 actagagcca ctccatttgt ttatacttga tgtaaaaact ttacacaaac cgggtaaggg 1238041 acagaaaccg ttgatgggag gagtgtcaat cggccggttt ctttgtctct ttcaaacaag 1238101 acaaggttgc ctgtttcttc atttgaagca acgaggaacc cttccgttgg gtcaaataca 1238161 aagtcacgag gccagtttcc ttctgtcgac actctttcta cgaaagccag ctctcctgaa 1238221 tattgattca cttcaaatac ggcgatactg tcatggccgc ggtttgcgac ataaacaaaa 1238281 cgtccgtcct gcgtgacatg tattgcgctt ccctggctgt tatctgtaaa atcatcaggg 1238341 atggcagaaa cgacttggat ttctctaaat tcgccggctg tcgggttgta ttcaagcgca 1238401 atcacttcat tgcttaattc tgtcatgaca taagcgtatt tttctttcgg atgaaaagcg 1238461 atatggcgag gtcctgcacc gggagcgaag gaatggcttc cggattcagt caacacaccg 1238521 tctttaagct tataggtgta gagcttatct atacctaaat caaccgctac cacataattg 1238581 tgttcaggtg tgaaccccgc gtagtgtgta tgcggttttt cttgtctttc gtgcggccct 1238641 tttcctgtgt gagcggcctc tgaaacaggt gattgcaagc tgccgtcttc ctgaaccgga 1238701 aaaacgtgta ccttcccgct gtgataattg gcagtcagta cgaattgatt ttgatcatca 1238761 acgcttacgt ggcatggcga agggccatca attaactgat gattcagaaa tgtcaattcg 1238821 ccgctgtttt tatcgatttg ataggcagca actccgcctt ggccgtctgc tttttcgatg 1238881 gaataaagga tggtgttgtt tttattcgtc gccacatatg tcgggttgcc cagcttagcg 1238941 gccagctttg gctcgctgag tgcttttttc tcagtatcaa gctcaaatga ataaattcct 1239001 tcgcttccgc cttttgtata tgttcccaca tatcctatgt attttgtcat gcgatttccc 1239061 ccttaaaaat gatgtcacct ctatattaac gtatcttgat aaaataagct gttcaaaaca 1239121 tgaaaaaggg gaagattctt cattcgcctc gaatcagcgg cattgtgcag cacctgaagg 1239181 agccgcctga tttaataatt tctgacaggt caatttcgat aatgtgatag cctcttttcg 1239241 atagctgttg attgacatgg cggttgccag ggagactgat gatcgttttt tttccgattg 1239301 aaaggacgtt ggtgccaagc gtaaattgtt cgtcctcggg cacctcaata agatcataac 1239361 gttttgccag catatcggct gcatctggct caatggcctg tgaataaatt aacgcttcgc 1239421 tttcagatat aatgttaaat acgcagtcca aatgcaaaaa tttttcatga agcttcactg 1239481 gaacgatcgt atattcagga agtgcctctt ctagctggcc gatagctgaa atgtcggtgc 1239541 gctggctgat tccgacatag acaatgtcat catcgataat gacgtctccg ccttcaatac 1239601 tcgtatcaag catgcgggtg taagagatac cttggctgtg aaaaaaatct tttataacgg 1239661 cttcttctcc ttggcgaatc ggttcagtca tgcttgacag aaaggctttt tctccgatga 1239721 caaatcctat gtccctagta aaaacctgtt ctgggagtcc gtcgcgaacg ggcaaaagga 1239781 cgacctcaac gttgtgtgac ctaagtgcct ccactaagcg gctgtgctgg tcgttagcgg 1239841 tttttacatg aatattgtca tcttcaaaat gtttttgtgt ttcgtttata acatctttta 1239901 tggtcatgtg ctcaggtttg cataagatca ctttttgaag tgtgccgtat tccgttcggc 1239961 ataccgtttt gtgctgagat ttcgggatgg atacgtccat ttgtttttcc tcctaaagtg 1240021 tgaagaatac atttattatt ccctcatcat gaaaatcatt aaaccatttt aaattttaga 1240081 caaatggaag agaatattgt ttaataggag aatataagtg catttagcta aaagatcaga 1240141 catcaaaggg gagaaaggta tggaaacacc ggaaacaaga ttttgtaaag agtcaaaggt 1240201 tgtgaaaacc agcagggtgt tcccgcttga cacgaacaac cataatacgc tgtttggcgg 1240261 aaaattaatg agctacatag acgacattgc ctctatttca gcggcgcgcc attgcagacg 1240321 tgaaacggta acagcttcaa tggattctgt agatttttta aagccgatcg ggcaaaagga 1240381 ttctgtctgc ctagagtcat atgtgacatg ggtcggcaca tcttccatgg aagtatttgt 1240441 gaaagttatt aaggagcatt tgatgactgg cgaacgggaa ctcgctgcca catccttttt 1240501 gacatttgtc gcattagatt caaatggcaa gccggtgcct gtaccgaggg ttgtaccgga 1240561 aacagaagaa gaaatcatgc tgcataatac agctgtacag cgtgctaatg aacgtaagaa 1240621 ccgcaagaga cacagccagg cgcttgcaaa tgcgctcgga actgataagc cttggtgaac 1240681 gttaaaccca aaacataagt tgttttgggt ttttttgtac ttttcaatgg tgattattac 1240741 aatggttagt ccgtttttgc taggggattc tataaaaaag caacaaatgt catgttaaat 1240801 tgataatttt gtgacaactt tattaaagat tcattttaga tatatctttt attcgtaaga 1240861 tcatgtattt taaagatata ttttaaatac atcttttcga aaggattgtt tataaaatgt 1240921 tagataacaa aacaatcgaa attattaaaa gcactgtacc cgtattgcaa cagcatggag 1240981 aaacaatcac tggccgtttt tacgatcgga tgtttcaaga ccatccagag cttttgaaca 1241041 tttttaatca aacaaaccaa aagaaaaaaa cacagcgaac tgcactggca aatgccgtta 1241101 ttgcagctgc ggcaaacatt gaccaattag gaaacatcat tccggttgtc aaacaaatcg 1241161 gccacaagca ccgcagtatc ggaattaagc ctgagcacta cccaatcgtc ggtaaatatt 1241221 tgctgattgc gattaaagat gtattgggag acgctgcaac tcctgacatt atgcaggcat 1241281 gggaaaaagc gtacggagtc attgctgacg cgttcatcgg aattgaaaaa gacatgtatg 1241341 aacaggctga agagcaagcc ggcggctgga aggagtataa gccattcgtt atcgcaaaaa 1241401 aagagcggga aagcaaagaa attacatcct tctatttgaa accggaagac agcaagccgt 1241461 tacctgaatt ccaagcaggg caatatatca gcatcaaagt gcggattcct gattctgaat 1241521 atacgcatat ccgccagtac agcctgtctg atatgccggg aaaagactat tatcgaattt 1241581 cagtgaagaa agatggtgtc gtgtcttcct acttacacga tgggctgcag gagggagatt 1241641 caatagagat cagcgcaccg gcaggggact ttgttttaga tcatgcatca caaaaagatc 1241701 tcgttttgat cagtgccgga gttggcatta caccaatgat cagcatgctg aaaacatctg 1241761 tttccaaaca gcctgaacgg caaattctgt tcattcatgc ggcgaaaaac agtgaatatc 1241821 atgcattgcg ccatgaagta gaagaagcag caaaacattc tgctgttaaa acagcatttg 1241881 tgtatcgcga gccgacagag gaagaccgtg caggtgatct gcattttcat gaaggacaga 1241941 ttgatcagca attcctcaaa gaactgattg ccaacacaga tgcggattac tatatttgcg 1242001 gttcaccgtc gtttattacg gcaatgcata agcttgtatc agagctcgga tcagcgccgg 1242061 agtctatcca ttacgagcta ttcggcccgc aattaagttt ggcgcagtcc gtttgaacac 1242121 atacatgaaa ctcttctcct ttcagagaag agttttttat tgagatataa gaaggcagac 1242181 aagcgccggt ttctacatcc ggacaatcac agacccgctg ccatttgtgc atacacggtt 1242241 ttgctgttct tgcattgttc tcagcaattc attgtttacc tcaatcgctc taattagttg 1242301 cttcattctt agctccaaac cggccagcct gtcgattgtt tgctgctggt agccctcggg 1242361 ttggggagcc aatggcagat caaagggcca aagggtattc gacttctgat ttttcatatt 1242421 gcgtattgcg cctccaatcg gtgtcacttt ctattatgtt atgttcaggc gatatgcacg 1242481 ttcgcctaga cactgatgca tagagggcct gccacggggc acaataggct caatatgacc 1242541 agcggatgga ggtaaagatc ggtgttatgg atggtatggg tatttttact gaagccagtt 1242601 atcgtatttt cgattgcata tattttgttt cggcttgccg gtaaaaaagc tgtgtcacaa 1242661 atgaacaatt ttgacctgct tttgaccttc gcaatcggaa ccattatcag tgagccgatc 1242721 cttacatcca agctgccgat gtcaatttat tatgcgggtg cttttttggt gctttatctt 1242781 atcatgagca agctctcttt atctaataaa tggcgatggc tcctagtcgt gagcccgact 1242841 gtcctaatcc gaaacgggga tattgatgaa cgcggccttc gtaaagaaag gctgactgtt 1242901 aatgagctgc tcggaaagct gagggaaaag ggctatgccg acccggctga cattgatctt 1242961 gctatcattg aagaaacggg agaagtaagc gtcatcccga aagaggaagc gagagcggtg 1243021 caggtgcggg atttgaatat ggaagctgaa cggaatttta tcccgattcc gctcatactg 1243081 gatggcgaaa tccttgatca taatttgaaa tatctccaaa aaaaccgatc ctggctgttt 1243141 gagaagcttg aggaaaaagg gtacagcccc aaactgctgt cttcgattat ccttggcacg 1243201 atgaatgcac gcggtgatat atcccttgat ttaaataccg ctaatgaacc gcagcatgat 1243261 ccttacttat ataaaccggg aaataacaat taagatggct ctctcttgta atgagagctt 1243321 ttttcttttt taaagggaat ttttgtttgg tgtcaaatgt acctagttag gaggggaact 1243381 gaacatgaag gacttatcca taagaaacga catggcgcca acggtcagtt tgctgtattc 1243441 cgcagtggaa gaaaacagtc tccgtctggc ttccatcgta agccatatga cacacagtga 1243501 actttactat aaggggcgct gccaaacaaa aaacagcacg gctcagcttt tgcaccatat 1243561 cacaaatgtt gatatcagat gggtctggcg tatcaaggaa aatcggatcc cggaccatat 1243621 tgaacaggca tacggcccga tgacagatga aagcggacgg ctgcctgaac cggtgaatca 1243681 gccagactta gatgaactcc tgaaaagaca tcagcatgta gtagagaagc tgaaatcggt 1243741 atgcttcact ttaactgaaa atgctttgaa ccagccgctt tccttcgaag gtgacaccgc 1243801 gacgatacga tggggaattt ggcatatggc agatcataac cgctatcatc aggcacatat 1243861 tgaagctctc aaaaaagaat ggaagcagga tgtggcgaag tatgaacgct aaaacgaagc 1243921 ttgtgactga tcgaattcgt ttgcgctgta tggaagatcg ggatcaagcc actttgtttg 1243981 ggctgctttt taatgatcct gacgtcatga catattattc cggtttaaaa gataagaggc 1244041 aaacccgcga gtgggtcaat tggaaccaac gaaatgaaaa agggtacggc gttagtctgt 1244101 ggatcgccga agataagcgg acaggggagt ttttggggca atgcggcatc gttccccagc 1244161 agatcgaaaa tcaaaccgta atggaaattg gctatatgtt tgcccgccgc cactggggga 1244221 acggctatgc gcaagaagcg gctcgggcct gtctggacta tggctttaac gagcggcagt 1244281 tcggcaaaat ggcggctttg attgatccgg gtaacaaagc gtccatacgg gtagcggaga 1244341 aaatcggcat gcattacagc aaaacgatca gaaaatggaa taaaccgatc gcggtatatg 1244401 aaagaaaatc ttacaattga aagatagagc tgagtttagt atcatgatat catgtaaagt 1244461 tttctagggt tccgcatgtc aattgacatg gactggtccg agagaaaaca catacgcgta 1244521 aatagaagcg cgtatgcaca cggagggaaa aaagcccggg agagtcaatc tcatgtgaga 1244581 cgactgtccg gggttttttt gttttcggag aatcttaata gatagaaagg aatgactcaa 1244641 aatgaaatgg ggattggtcg tgcttgccgc tgttttcgag gttgtttggg tgataggctt 1244701 aaagcacgct gactcagcct taacatggag cggcactgcc atcggcatca tattcagctt 1244761 ttaccttcta atgaaggcga ctcacagtct gcctgttggt accgtgtatg ccgtctttac 1244821 cgggctcggc acagcgggaa cagtacttag tgaaatcgtt ctttttcatg aaccggttgg 1244881 atggccgaag ctattgttaa ttggcgtgct cttaatcggt gtaatcgggt tgaagcttgt 1244941 gacacaggat gagacagagg aaaaaggagg cgaggcataa tgctgcactg gatcagttta 1245001 ttgtgcgcgg gctgtttaga aatggccggc gtggccctta tgaatcaata tgcgaaagaa 1245061 aaaagcgtga aatgggtgct gttgatcatt gttggttttg ccgcttcatt ttccttgctg 1245121 tcgtacgcaa tggaaaccac tccgatggga acggcttacg cggtctggac aggaattggc 1245181 accgccggcg gggcgcttat cggcatcctc ttttacaagg agcagaaaga cgccaaacgg 1245241 atcttcttta tcgcgttgat tttatgctca gcagttggtt taaaaattct gtcataaatt 1245301 gatttttatc aaatcttcag tataatggat aaatagttta gacttacaaa gataagaggg 1245361 attattcatg aaatcatata tgactcagcg gttggacgaa taccgtgacg gaaatgagga 1245421 taaaggtcgg ctcttggtca gctgccccga tcagccgggt atcgtctctg cagtttccgc 1245481 gtttttattt gaacacggtg ccaatattat agaatcaaat caatatacga cagaccctga 1245541 aggcggccgg ttcttcctga gaatcgaatt cgactgcgca ggcattcgtg aaaaaaaatc 1245601 atcacttcag gcagcgtttg cctctgttgc ggaaaaattc gacatgacat ggagcttaac 1245661 tttggcgagc gaactgaagc gtgtcgccat tttcgtttca aaggagctcc actgcctgca 1245721 tgagctgatt tgggaatggc aaaccggcaa cctgatggcg gagatcgctg ttgtcatcag 1245781 taaccatgag gaagcgagag agctggttga gcgcctgaac attccattcc actatatgaa 1245841 agcgaacaaa gacatcagag cggaagtcga aaagaagcag cttgaactgc tggagcagta 1245901 cgatgttgat gtgatcgtgc tcgcacgcta tatgcagatt ctaactcctg attttgtttc 1245961 ggctcatccg aatcgcatca tcaatatcca ccattcattc ctgccagctt ttatcggtgc 1246021 gaatccgtac aaacgggcct acgagcgcgg cgtgaaactg atcggtgcga catctcatta 1246081 tgtgacaaac gatcttgatg aagggccgat cattgaacag gatattgagc gtgtggacca 1246141 ccgcgataat gcggaagcgc tgaaaaacat cggaagaaca attgagcgca gcgtgcttgc 1246201 ccgtgctgtg aaatggcatt tggaagaccg tgtcatcgtt catgaaaata aaacaatcgt 1246261 ctttaactag actgcaagag gcccgcgcaa tgcgggctat ttttgatgac aaaaaacctt 1246321 gacaagtgtc ttttttcttt gcataatata aaaaaatcat tgagcgttga agaggattag 1246381 taagcagacc tttctgtgac agagagcaaa atgaatcgct gaaacatttt gccgcatgaa 1246441 acctgccgaa cctgccttgg agtcctaggg ggaaaaccta ggcgcataac ctggcgttac 1246501 aggagagcgg agcgtgcaca agcgcgttca atcaaggtgg taccacggaa acccatttcg 1246561 tccttatgaa tcaggatgaa atgggttttt ttattgtaga agagccgcgg aggagaataa 1246621 atgaaaaaac aaagaatagt agtgaaaata ggaagcagtt cgctcacgaa tagcaaagga 1246681 agcattgatg aggcaaaaat cagagagcat gttcaggcga tttccgtgtt aaaaaaagcg 1246741 gggcatgaaa tgattctgat tacctcgggt gccgtagcgg cggggttttc cagcctcggt 1246801 tatccatccc gtcccgttac catcaaagga aaacaggcgg cggccgcggt cggacaaaca 1246861 ctgttaatgc agcaatatat gaatcaattt aaacaatact cactgactcc gggacaaatc 1246921 cttttaacga gaaatgattt ttcgaaaaga gaacggtatc gaaacgcgta tgctacgata 1246981 atggaattat tagagcgggg cgtcattccg attatcaacg agaacgattc tacatctgtt 1247041 gaagaattga cattcggaga taatgatatg ctttctgcgt tagtcagcgg attgattcac 1247101 gcggaccagc tcatgattct cactgacatt aacggactgt atgatgccaa tccaaatgaa 1247161 aatcctgagg cgaaacgatt tgattatttg ccagagatca cgcctgaatt gcttggatat 1247221 gcaggttcag ctggatcaaa ggtcggcacc ggcggaatga aatcaaagct gttagccaca 1247281 caaaccgcgc tgtctctggg agtgaaagta ttcattggaa ctggcagcgg agagcaaaaa 1247341 cttgcggaca ttttggacgg caggggagac ggcacttata tcggagacaa agaactatct 1247401 tcggttaaca acacaaggca gtggattcag ttccactcgc cgatatcggg agaaattatc 1247461 attgatgcgg gtgccgaaga ggcgatgatc cataatggaa gcagcctttt gcccgctgga 1247521 gttgtgggcg tgaacggaag ctttccgaaa ggggcggttg tggaagtcag gggaccgggc 1247581 ggcgtgatcg gcaaaggcca aactcattac tcctccgagg agattatgga ggctaaaggc 1247641 aaacgcagtg acgaacttga ttttgagaaa acgtttgagg ttattcatag gaatgactgg 1247701 gtcaatgtaa aagactagga ggcggaaaaa tgagtgaagt ttctgtaaaa gcgaagctgg 1247761 cgaaagaagc agcagccgaa atgatcatga aaacaacagc cgagaaggat gaggcgctca 1247821 gcctcattgc aaacggactc cgcaaagaac tggattttct cttggcggag aatgcaaaag 1247881 acattgtgaa cggaaaagag aatggtttaa caccggacat cattgaccgt ctctcattgg 1247941 atgagaaacg gatacgcgat atcgcggacg cggtggagct cttaatcgac ttagcggacc 1248001 caatcggcga ctctcttgaa acgattgaaa aagaaaacgg cctgtttatt gaaaaaatcc 1248061 gtgtgccgct cggtgtcgta ggaatgattt atgaggcgag gccaaacgtc acagttgatg 1248121 cggctaccct ttgcctgaag acagggaacg cggttgtgct gcggggaagc tcctcagcca 1248181 tccacagcaa caaagcgctc gtcagtgtca tttacagagc acttgagcaa tcagcgcttc 1248241 cgattcacgc tgtgcagctg attgaggata cgagcagaga gacagcaaaa gagctcttta 1248301 cgttaaatga tggcttagac gtattgattc cgcgcggagg caagaaactg attgatctcg 1248361 ttgtgagaga atcaacagtt cctgtattag aaacgggagc aggaaactgc cacatattca 1248421 ttgacgaaac agccaaaccg caaatggcag aaaaggttgt tgtaaatgcc aaaacgcagc 1248481 gcccttctgt atgcaacgcg attgaatcat tgctgattca caaggcttgg gcaagacagc 1248541 acggaaaaga attgctggac cagctggaaa acgcgggagt tgaaattcgc ggtgatgaat 1248601 tggtatgtga acttcatcct tcaagcaaac aagcatcaaa agaagattgg gaaaccgaat 1248661 ttttagcgcc tgtcctcagc gtaaagacgg ttgaaaacgt ccaagaagct gtaaagcata 1248721 tccaacaata cggcaccaat cattctgaag cgattttaac tgaaaatgac aaaaatgcgg 1248781 tatattttca aacggctgtc gatgctgccg ctgtctatca taacgcgtca acccgcttta 1248841 ccgacggctt tgaattcggc tacggagccg aaatcggcat cagcacgcaa aagcttcatg 1248901 caagaggacc gatggggctt cctgcactga cttctacaaa atacatcatt aaaggaactg 1248961 ggcaaatccg tgaatagcgg ggtaatgttc aatgaaaaag cttatctcat tacgagataa 1249021 gcttttttat acgcgaaaaa ttgacatttc aaatttaatt gtgtacaatt taattgtata 1249081 aaatatattg ggggaatgaa aaatgagtca gccattattt accgcaactg tttcagcggt 1249141 aggaggaaga gaaggaaagg tcatttcatc agaccgcgtt cttgagcttg atgtcgcaat 1249201 gccggggaca ccgagagcca agaaattaga aaaagcgaca aatccagagc agctgtttgc 1249261 agcaggttat gcagcttgct ttgacagcgc cctgcagctt gtcgcaagaa cagaacgggt 1249321 aaaagtagag acagaggtta cagcaaatgt tagcctgtta aaggatgaag cggaccaggg 1249381 ctataagctg ggtgtgacgc tgcaagtaaa aggagaagga gtcagtgcat cagaattgga 1249441 ggcgcttgtg aaaaaagcgc acggcgtctg cccgtactca aaagcaacct ccggaaatat 1249501 tgatgtgaca cttgaagttg ctgaataaat aaaaagagga tgcctgtaca aggcatcctc 1249561 aatttttttg atgaagtgtt tccagtaatg tatatagagc ggactttaac tgtttgagat 1249621 cctccccaga ctgctttgag agccccagaa ttgtccctgg aatgtcaacc gctttttctt 1249681 ttaataacgc tccgtcctct gtcaggctga tcaacacgga ccgctcatcc tcttcagatc 1249741 tttttctcgt aatcaaaccc tgttgttcca ttcgtttaag catcggagtg agcgttcctg 1249801 aatctaaata cagctgttcg cccatttttt tgacagtaag cgtttcatgt tcccataaca 1249861 aaagcaaagc caaatattga gggtatgtta tattcagctt atcaagcagc ggcttgtatt 1249921 gctttgtcat ctcccgcgaa ctcgcatata gcaaaaaaca aagctgattc tccaatttca 1249981 tatgatcaaa tttattttcc attttgttca ccaactcttt tttgtcattc gattctattg 1250041 tatctgaaaa acctcacttt tcctattctc ggcaaacata gcatgtttaa aaagatcaga 1250101 aagggaaata taacaactag atacaaataa ggaggttggg aaatatggca ctatttacag 1250161 caaaagtaac cgcgcgaggc ggacgagcag gacatattac atcagatgac ggtgttcttg 1250221 attttgatat tgtcatgcca aatgccaaaa aagaaggaca aaccggcaca aatccggaac 1250281 agctctttgc ggcagggtat gctgcatgct tcggcggcgc gctcgaacac gtagccaaag 1250341 agcagaatat cgaaattgat tcggagattg aagggcaggt cagcctcatg aaggatgaga 1250401 gcgacggcgg gtttaaaatc ggtgtcacac ttgttgtgaa cacgaaagat ttagatcggg 1250461 aaaaggcaca agagcttgtc aacgccgctc atgaattctg tccttactca aaggcaacca 1250521 gaggaaatgt tgatgtaaaa ctagaattaa aataatgacc ggcatcctga ggattctcag 1250581 gatgtttttt ggtgtcggac atgcggggcg ggcacagatt tatgataaaa cttcagagaa 1250641 gcgtttgaag catgccttta aaccaaaagt tacagatgaa gcgggtggct ggcacggtgt 1250701 ctgccgtgct gaattgcgcg tatatgctgt tttgtatttg cacagggcat agcggctact 1250761 tggagaaata acaaggacca ggccgcgcat gcctgatcct tttaatattc tttcttattg 1250821 gcgaagttcc gccatgcttg aaacggggat aaatgctctg ttagtgtcac ttgataaaag 1250881 gggatcgttc tttcttcagc aggtttatca atttctttat aaatgaatga atcatcaaac 1250941 ccggcttcgg cagcgtctgt gtgctcagct gcatagaaaa cggctttagg ccgggcccag 1251001 tagatggcgc ccaagcacat tgggcatggt tcacagctcg tatacaaaat gcagtcatca 1251061 agctggtagg ctcctagcac cttacaggct ttccgaatag ctgtgacttc cgcgtgggca 1251121 gtcggatcat tgcttgttgt gacgttgttc tgtccctctg caataatggc tccgtctttc 1251181 acgataacgg ctccaaaagg cccgccgatt cctgcattca ctccttcaca tgcgagagtg 1251241 acagcccgtt ttaagaacgt ttcatgattc atcccaatcc ctcctgtcaa tagagtgtta 1251301 ttagtatagc cgaaaagaat gcaaagaaca ttcttaaaaa agtgcaaaat aaacaaagta 1251361 tttgggggat ttgctaaata agaaaccgat tgtggctgta ttatagaaaa aaaccatctg 1251421 ccaaatgcag atggtttttt caaattatac tagctgtgtc tgctgtgctc ttgcctgttt 1251481 tgcggcttca accatatttt tcaatgctgc aaccgtttct tcctgctgtc ttgttttcaa 1251541 tccgcagtct ggatttaccc agaagcggtc agtcggacag acggcaagcg catcaacgat 1251601 aatattgtac atttcttcag ttgacggcac acgagggctg tgaatgtcat atacaccaag 1251661 gccaagccct ttcaaatacg ggtggttttt taagtaatct aaaaatcctc cgtggcttct 1251721 gctatgttcg attgtaatca catcggcatc aagatcattg attgtatcaa cgatatcttc 1251781 gaagttgctg tagcacatat gtgtatgaat ttgtgtctcg tttttcacgg aagaagtggt 1251841 taatctgaaa gcttctgccg cccaagtcaa atactcatcc caatcgcggg ttttcaatgg 1251901 aaggccttca cgcagcgctg gttcatcgac ttgaatgatt tgaatgcctg cgtcttcaag 1251961 cgctttaact tctttgcgaa gggcaagccc gatttggaag gcgatttctt tcctcgagat 1252021 gtcgtttcga gggaaagacc agtttaagat tgtaaccggg cccgtcagca ttcctttcac 1252081 atgcttggaa gtcaatgact gtgcgtagac tgtgtctttc actgtcatcg gttcaataaa 1252141 ttcaacatct ccgtaaatga ctggcgggcg gacacagcgt gagccgtatg attgaaccca 1252201 ggcatattta gtgaaggcga aaccggccag cttttcaccg aagtattcga ccatgtctgt 1252261 ccgttcaaat tcgccgtgaa caaggacatc aagctccaat tcttcctgaa tatcaatcca 1252321 tctttttgtt tccgcattga taaagttttg atactgttca tcggaccact cagctttccg 1252381 ccatttttgg cgtgcgctcc gcacttcagc agactgcggg aagctgccga tcgttgtcgt 1252441 cggcaaaagc ggaaggccga gagattcatt ttgtagggct aaacgttctt caaacggaat 1252501 cgggcgcttg aagtctttat cagttaattg ctcaagctct ttcttttgtt cagaattggc 1252561 gcctgttgca aactgtttaa gcgcctggat atcagcctta gcctgctgaa tctcttcgct 1252621 gatcgccgct tttcctgata ctaagccttc tttcaaagct gtcagctcgg ccagcttttc 1252681 ttttgcgtag gataatccgt tcaataggtc tttttccaaa tgctcatcag ggtgtttcgc 1252741 tactggaaca tgcagcaggc tgctggaagg ctgaatccac agttcatcaa cttttgcaat 1252801 gctgagaata tcaagaacgg catcgagacg ctcttcaagg tccgctttcc aaatgttgcg 1252861 tccgtcgata acgccggctg ccagcacttt atctgtcggg aagccatgtg ttttaagctg 1252921 ttccaggttt ctgcctttgt cgtgaacgaa atcaaggcca attccctgaa ccgggtaaga 1252981 gatcagctct tcataagcat caacagaatc aaaatacgtc tgcaaaagca cattcaagga 1253041 tgaaagctca cttgtaatgc tttcaaataa ttcttttgcg ccgcgtacat cttcactaga 1253101 ggcggtaacg agcgccggct catcgatttg aacccatttt acgccttctt cttcaagctc 1253161 tttcaaaagc tgtacatata atggcacaag gcgtttttgg atcgcttttg cttcagacgg 1253221 ttcatagcct ttagcaagcg taacgaacgt ataagggccg acaatcacag gctttgtttc 1253281 cacaccgtat tcctgtttga tccggcgata atcttcgagt tgtttgtttc ttgtcagacg 1253341 gaactcaatg ctctcgtcat attccggaac gatgtaatgg taatttgtat taaaccattt 1253401 tgtcatttca ctagatacag cgtctttgat tccgcgggcg atagcgaagt atgtatcggt 1253461 agcgtcagtc aaatgtctga accgtttcgg gatccagttg aagctgactg ctgtgtcgag 1253521 tacatggtca tactgtgtga aatcagaaac aggcacaaca tcaatctgct ggtcaatttg 1253581 tgtttttact gcggataaaa atagttcgtc gatttgcttc aaaaacgtat ctttatcagt 1253641 actgcctttc caatacgctt caagtgcttt tttccattcc cggttcagtc cgattctcgg 1253701 aaatcctaaa ttcgatgttt tgatggttgt cattgtttct cctcctttat atgtaaaaca 1253761 ctctctttca cccgcggata caggctgcta agaggttttc tcacaacaaa aagcctcttt 1253821 cccatgagag aaagaggctt ttctacgtaa aacactgcct ctctcatctc tcagacacaa 1253881 tctgatggaa ttagcaccgt gccttatgag acatcagtct cggcgcgaaa agcagtgcgc 1253941 cccatttcac aatggtatta cggtcggttg ctgttggggt caaaaggcca atccctcgcc 1254001 caactctcga taagagaaaa tgttattaat tttttgaaaa gttgaatcat ttgttggtaa 1254061 tcttaacagt aattcaaatt cattgtcaac atagaatttg aaatttttat ttacatgatg 1254121 tggtgtatat tatataagaa aaataatctt atagggtcaa caaatgtgat tgctctgctt 1254181 tttctgcgag ctcatcagga gctgttaaat acaggaatcc attgcctgcc agcgtttttg 1254241 caatatcaag aggaagtgtc ctgcggatta gctgtgcgaa aacctcagat tcagaaagct 1254301 ttctttgaaa tgattcttct tcatagcttt tgattaaagc aagcgcaccg ctgacatgag 1254361 gggcagccat tgaagtgccg gtcagcttac cgtacttctt gttgggaagg gtggataaga 1254421 tgttttctcc tggtgccaca aggtcaatct ctttattcgc gttagaaaat tctgataatt 1254481 ctcgcgctac agaaacagat ccaactgcaa tcacttcatt ataagctgcg gggtaggaaa 1254541 gctcttctgt gcgttcgtcg ccgtcacctt catttcccgc tgcacaaacg acaagcactc 1254601 cgtttttcac tgcgtttttc actgcttctt ttagctctgg cacatcgctt ggccctccaa 1254661 gggacattga gatgatgtcg actttctgtt ccaccgcgta gttgatgccg ttaattatcc 1254721 attcgtattg tccgctgccg ttctcgccgc caagaacctt cacaatcaat aggcttgcct 1254781 caggcgcgac tccggcaatg cctccgtttg aatcattagc tgcaattgtt ccggcgacgt 1254841 gtgtgccgtg tccgttgtag tcggaaatcg catcttcctt gccgccgtcg tcatccgtga 1254901 agttctttcc gccgatgatt tgatttttta aatcagggtg gcttgtgtcg cagcctgtgt 1254961 ctaatacagc aactttaata tttttgcctt ttaccccttt tgcccacatt tctggcgcct 1255021 taatcacttt aatgccctca ggaagctcgt ttacatccat gatctgctca ttcgtcacat 1255081 acgggatcaa gcggatttca ccattcataa aaaagccctc cttttttatg cttgcaagtg 1255141 gattcaaggg tgttgcctca tattatatga aaaaagcaag cgctcggaca gagccatttg 1255201 aagcattttg aaaaaatagg atacacacca aagaattagt aatcttcaaa atattggatg 1255261 gcttcaacat gtatgactgg gattcaactg taagtcaagt tataatagtg ttggggaaag 1255321 gagcagtgtc atgaaactga atgaaaaatt atatgcattt ttttcagagc atgtggaaca 1255381 aatggccgag gaatggattg aaacgatgga ggaaagtgat ccgaattcgc tttacgccct 1255441 acataatgca acagtaacgg aagaattgaa agagcaggac agagaatttt accggcatct 1255501 gaattacatg tatgttttac cggaaaaaca atttctcgaa gagtttcaag agtgggtcat 1255561 tgagctgacc aacgatcaaa aacatctcga cacaccggtt cagtatgtca ttcgggagtt 1255621 tatgagaaac aggagattat atacgaagta ttttgagaag ttcgcagaag aaaatgaatc 1255681 agcgtttgaa ccgggagaga agcaaaaatg ggcagatttg attgtaaaag tatttgattt 1255741 caccatttat acattcgttg atcacgctga aatgaatgcc aagcagcaat taaacgccca 1255801 aagagaaatg atattggaat taagctcacc tgtcattacc ctgagcaaat caacagctct 1255861 gctgccgctt gtcggtgaca ttgataccga acgggcgaag tttattctgg aaaacacgct 1255921 tcaagcttgt gcgaaaagac gtgtggagca tctgttaatc gatctgtcag gtgttgttgt 1255981 ggtggatacg atggtggcgc accagatctt taaattgatt gaggcgctta atctgatcgg 1256041 tgtccggtca accctgtcag gaatcaggcc tgaaattgcg caaactgctg tacagctggg 1256101 gattgacttt tcgaatatta ctattaaaac caaccttgcc caagcattaa actatcatca 1256161 ataaaaaaat ccgctatctg tgatagcgga ttttttatga tgcgaaacat aaagatacga 1256221 gaaaggatcc cgcgaataat aagaggacga ggcaaaagaa cacccagtcg cgccggttca 1256281 cgctcaatgt cctgtagtat gtccggtttc tgcttcctgt aaatcctttc gattccatcg 1256341 caagcgctgt ccgttccgct tttctgatgg cgcttgccaa tagcggtatg gtatatcgtt 1256401 ttaacgcact gattttatta atgatgccgc tctccgccgc tcctcctctg attttatgag 1256461 cctgctgaat cagctggacc tcatccttta acagcggaag aaagcgaaag cctgcaatga 1256521 caccgtacgc gagctttggt gagagcctgc actgctggac aaggctcagc ataaatagaa 1256581 tcggatcggt tgtaaaaaca aacatcatcg ataaggcgga aaagcataaa atacgaaacc 1256641 cgagagagat gccgacagac acattatcgc tgttaatgga gatagggcct gcttgaaaca 1256701 aaaaattatc cggtgttgtc ggcacttttc caaaaactgc ggctgtccac acgcatccga 1256761 atgctaaaat caaaaacgga atcgtaaaca acaaccattt tttcaatggg attccggccg 1256821 ccagtaaaac gcccgcaacg atgatgatat aaaaacatgc cggagtgtaa gggttgtaaa 1256881 taaacgacag catgacgaca caacaaaaaa ccgccgccgc tttcacagtc ggattaatga 1256941 gatgtaacgg ttgcttcatc acgcacctcc tcttgaaatg ccatccattc atatagaagg 1257001 ggaagggtga gctttgcttt ttgaacaagc cctgtttctt gagaaaacaa ctgcgctgga 1257061 gatccgtcaa aggccaggcc tgtatcgtga agcacaagca cgctgtcagc atacgaagag 1257121 actagctcca tatcgtgtgt aatcataagg acagcagttc cctctgcctt gatacgttga 1257181 atcatttcca tgcattcagc cgccgtgcgg gcatcctggc caaaggttgg ttcgtctaat 1257241 aataaaacct ttacgtcatg catgagcata gtagctacgc tcagtcgccg tttttgccct 1257301 tggctgatcg caaacggatg atgatcagcc aaatgcgcaa gaccaaaacg ctgcagcagg 1257361 tgttgcgctt ttttctcagt ttcagcattt gctttctggc cgaacagaag ctcgtcatac 1257421 accgtatcgg tgacgaattg atgctcaggg ttttgaaaaa caaatcccat ccgtttacgc 1257481 aattcttttt ctttatattt ctgcagcggc tgatcataga gaaggatttt gccgctttgc 1257541 ggtttcatga gactggccag aactgatagg agcgtcgatt ttccagttcc gttcggaccg 1257601 acaagcgccg ttaaagagcc ttcgcgcaac gaaaagctga tgtctttgaa aatcgcctgc 1257661 tgtcctctcg cgaacgaaag gctgctgact tcaagcacac tctccccaga aggggctttc 1257721 ttctttttga catgcccggc aggaataggc tctttgaaca gcatctcttt tgataaagta 1257781 aacggcatac tcagcttttc ctgcagatga cagacctttg gaatggcgat gcccaatttc 1257841 tttagtgtct ccgcttcatg ctgaaataga tttttcgtca ggccatccag tgcctttttg 1257901 cctgatttgt cgagtacgat cgttctctca atccaaggcg cccattcatc aagctggtgc 1257961 tcaatgacga ggaggctgaa acctttttcc cgctgaagat ccttcatcag atgaacgaac 1258021 tcccgagctg agaaagggtc taaaagagag gtcggctcat ctaaaataat aagctcaggc 1258081 tccatcgcca aaatacaggc gagagccact ttctgctttt gtcctcctga aagggttgag 1258141 atcatttttt cttttaaatg ggtaatgcgt aatttttcta atacggcgtt gattttctct 1258201 gtcatttctt cttttggaat ttgcagattt tccagcccga acgctatttc gtcctccacc 1258261 gtcagcatgc agaactgctg atcaggatcc tgaaaaacga ccccggcatg ctgagtaatc 1258321 gtttcggagg tttcagcatc tgtgaccggc ttttgaaata gaaatacatg tccggactga 1258381 atgccgtcgc aagcctccgg atatagaccg tttaaacaaa gggcgagcga gcttttaccg 1258441 catccgctcg gtcctaataa taaaacacat tctccttttt gaagctcaaa cgaaatgtct 1258501 tgaaaaaccg gtttctcgtc ttcttcataa gagaagctga gctgctcaac cgtcagaagc 1258561 tcatcaaagg cttgcatgtt ctgacgcccg cttccgtttc tttttcagtt cctttccgag 1258621 tgccattccg tttaacacac ctgtataagc gagagagtcg ctgacagctt ttccgagaag 1258681 ccccgccaaa agcgcgccgg aaatgaggcg gatcacaagc ataatgagca gataacctgg 1258741 tgaataggct gcatagccag aaacaaagag atcatagata aagctggcta ctgaagaccc 1258801 cataccggcc agcataagga cagggagaga gtatgctttc cagcgtgttg caagaaatac 1258861 agcctcagcc ccgagccctt gaacaatgcc aatgacgatg accatcgggc cagacggatt 1258921 tcccagcagg cactcaacga gagcggcaat gatttcagaa acgagcgccg cacccggttt 1258981 tcgaatcatg tacgcggcga tcacagaaac gataaaccaa atgccgtaaa ttggttcata 1259041 ggcgattggc ccaaacatac ctgcaagtac gtttccgaaa tgtgtaaata ataaataaac 1259101 aacggcaaat acgatactga taacggacat gatgacaatt tcttttactt tccagctttt 1259161 catgttatcc ctgctttctg ttttttcttg atggactgtt agccgaaaga ttcacagtca 1259221 tggtgatgtg gtttgtttgc tgctcagcca tgcggaaaac ggcctccaat gtgctgaata 1259281 cgtcatgcgc atccccgtca agctcgctcg cgtaatggac accctgtacg aaagtgcctt 1259341 gggcttttgc aatgtcgaca gcctccataa tcaatcccat ataatccggc tcattcattg 1259401 gataaagggc aaattggcac ggcgcttccg ccttcaagcc tcggacagca tcttcattga 1259461 cacgcttatc acctttggaa agatatgtat ccccctgtgt gtcacccggg catccaatgg 1259521 aaaacgtgcc gttcatgacg atgtgttgtt cgctgtttgc tgcatgaagg taaatggctt 1259581 ttgcagcatc gaatacatga tcaatcgatc cgcgtaacac cgtgctgata tggtcggttt 1259641 tcgtccaaac cttggatgta tctgtttttt tcagcgcaga cttgatcaca ctgataaaat 1259701 catccgtcat cggatataaa gagaagcgaa aaccggcgat tctgcttgta ccgcaaatat 1259761 gctccatttc tccgacctcc tgtttttttg gtaaaataaa aaactgcata tcctaaggga 1259821 atatgcagtc atagatcgat taagcgcaca aaaaaataca ccattcggtc aacctgcact 1259881 tccccacgct ggtattatcc agatcgggtc ataagggatc aaagcgcgtt tcttccgcgc 1259941 tttatctcag ccaaaacagc acccctagtg ctttccgtat acaatttttt attttgacat 1260001 cataatagat gataagaatc attttgtaaa caacgaaatc atttttttca tatagggacg 1260061 ggagaggatg gtcaaatttg gaaaaaggac acatattaat tgtggaagat gaagaaaaaa 1260121 tcgccagggt tcttcagctt gaattggaat atgaaggata cagcgtcacg atcaaacaca 1260181 atggcacaga aggtcttgat gcggcagcgg aaggcgggta ttccttggtg cttcttgatg 1260241 tcatgcttcc ggggcttagc ggactggaag tgctgcgccg cttgagaaaa acggattcgc 1260301 agacaccggt catattatta acggcgcgag acagtattcc tgataaggta acaggtctgg 1260361 acatcggtgc aaatgactat gtcaccaagc cgtttgaaat cgaggaattg cttgcgagaa 1260421 tcagggcggc gctgcggcaa aatggaacaa aaactgaaga tatcggcacc tttcttacat 1260481 atgacgattt gcgggtgaac gaaaaaaccc gtgaagtgag acgcggagac aaagaggtgg 1260541 aattaacgcc gcgggaattt gatctgctcg tctatatgct aaagcatccg cagcaagtgc 1260601 tgacacggga gcaaattcta agctcagtat ggggatttga ttatatcggt gatacaaatg 1260661 tcgtggacgt ctacataaga tacatcagaa aaaaactgga ctatccttac gaaaaacagc 1260721 tgatccatac gattcgcggg gtcggctatg ccattaaggg gtaaacgatg aagctgaaga 1260781 ccaagattca tctatacact tcgatatcac tgttgatttt attaattttg gttcataccg 1260841 cagtatatct cattttttcg tctgcgctga catcaaagga tgcggcccgg cttgctgatg 1260901 agacggataa cattgccgaa gcgctgcgtg ccgctgaaac agaaggagtg gctttgcagg 1260961 atatgctgca ggcctatctt ccggcaaatg gcatggtgcg tgtagtgaat ggtgatcaaa 1261021 aagccgttat gacgatcaca aaagaaaaag cctataaaga ttttcctctc tcttttcata 1261081 gcggcgaaac ggcagatgtg aggaaacctg acggcaagct gtttgccgag gctgctgttc 1261141 cggtgatttg gaccgatgga caagtcgtgt ctcttcagct ggttgaaaga ctggagaaca 1261201 cagaagagag tctgtttctg ctgaaaatca tcttaatcgc tgcaagtgct gctgtctgca 1261261 ttgcttcttt ttttgcaggc agcttgctag cccgccgaat catcaatccg atcagacgat 1261321 taatgatcac aatgaaagac atacagcgag acaaagaatt taaaacgatt tctttagaag 1261381 gacagtccaa cgatgaattg tatcaaatgg ggctgacatt taatgaaatg gcaatgatgc 1261441 tgaaggagca ctatgataaa cagcagcaat ttgttcaaga tgcttcacac gaattgaaaa 1261501 ccccgctcac tattatagaa agctacagca gcctgatgaa gcggtggggt gcaaaaaagc 1261561 cggaggtgct tgaggagtcg atagaagcca ttcactcaga agcggtgcat atgaaaaaac 1261621 tgaccaatca gcttttggcg ctggccaaaa gccatcaagg actcgaggtt gatctgaaaa 1261681 caatcgatct gattaaagcg gcgcgcgcgg ttatgcaaac gctccagtcc gtttatcagc 1261741 gtgacatatt gcttgaaaca gataaagaga gcctgcttgt aaaggcagat gaagaacgca 1261801 tcaagcagct gttgaccatt ttgcttgata atgcaataaa gtatagtgaa aagcctattg 1261861 agatgtcagc cggaacgagg aatggacggc catttctatc agtgagggat gaaggcatcg 1261921 gaatacctga ggagcatatc ccgcatttgt tcgaacggtt ctaccgggca gatgaggcac 1261981 gaaacagaaa aacaggcgga acaggtttag gcctttccat tgccaagcaa atcgctgatg 1262041 agcatggcat tgagctgtct gtcaaaagca agccgggaca aggaacagct gtcaccatgc 1262101 aattcagcga acagaatggg ggaggccgat gactaaaaca ataaaaacag tatcttttgc 1262161 tgcagcagcc attttagttg tcatcatctg tacgtttctc atcattcggc aaacccatga 1262221 gaacgtattg tcaaaggaga ctgtcgtaaa aaaagtcgaa gcctcttatg aaggcaaggt 1262281 cacgaaagca acacaatcaa aggataaaaa aacatatgat ataacccttg aaaatccaaa 1262341 gggaacttac tttgtaaaag cagacgcaat atcggctgac attctttcaa tgaatagagt 1262401 aaaagcagtg aatccatctg ccatgacaga aaaagaagcc gagcatctcg cgcttgagcg 1262461 ggtgccggga acggtcaaaa aacaaacacg gcaaagtcaa gttgccactt ataccataca 1262521 aaaagaagac gggaaaacat acgaagtgaa ggtagacatg caggcaaaaa cagtcttgtc 1262581 tgccgatcaa atcagcagca aagatcaaca aaaaacgccg attacgaaaa aagaagccaa 1262641 aacaattgca gagcgaaaaa cgggcggaac agcggatgac gcagatctcg aagaaagtga 1262701 gggcactctc atctttgaag tagacgttga tcttcctgat aataaggaag cgacagtgaa 1262761 aatcaatgcc tacacaggaa aggtagctaa cattgtgtat gaagactgac ggtttctcat 1262821 caaattctca tcttgctctc gttttccttt catgttgagt atgtaaactg tactcataca 1262881 aaacaaagga gggctcacaa atgctcaaga aaaaatggat ggtcggtctt ttagcagggt 1262941 gcctagcggc cggaggattc agctacaacg cgtttgccac agaaaacaat gaaaacagac 1263001 aggcttcttc taagacggat gcactcactg aacaagaagc agaagcaatt gctaaaacag 1263061 ttgttgacgg cacagtagaa gacattgaca gagaccttta caacggcaaa gaagtctatg 1263121 aagtggagat tgaaaaagaa ggtgaagact acgacgttta tgtagatatt catacaaaac 1263181 aagcgcttaa tgacccgtta aaggagaaag cagaacaagt cgccataacc aaagaagaag 1263241 ctgaagaaat tgctttaaag caaacaggtg gaaccgtaac agaaagtaag cttgacgaag 1263301 atgacggtgc ttacatctat gaaatggaaa tccaaacgaa gcaaggaact gagacagaat 1263361 ttgaaatttc cgcaaaagat ggacgcatta tcaaacagga gatagatgac taatcaaaac 1263421 ccccgctgca gcgggggttt ttcatgataa gaaaccttct tttggacaat ctaagtagaa 1263481 aaggaggcga aacgcatgga aaagaaagag gagcaataca tcaatcaggc tgaatatgtc 1263541 cctcatccga cgaaggaagg agagtatgcc ttatttcttc atgaaacgta tcatttgctt 1263601 tctgaagatg acgagacaca aacaacagaa taagggctta ggcccttgtt ttgttccgta 1263661 attgtgatgt aagcgcattt attacttttt tgagttgaca tagcttgttt ttttctgtaa 1263721 tctcagtgtg tcaattcaat taggaacttc gttaggtgag gctcctgtat ggagatacgc 1263781 tgctgcccaa aaatgtccaa agacgccaat gggtcaacag aaatcatcga cataaggtga 1263841 tttttaatgc agctggatgc ttgtcctatg ccatacagtg ctaaagctct acgattgaag 1263901 gcgcccgcac gctttttttg ccgtgcttct ttcaccttca atcccgaagg ctttttttat 1263961 gcctttaaaa cgaaaccaat caaaggaggt gcggagtatg gattctcccc attcgagtca 1264021 atctgaagaa gtacccatat actatgacag caagacaatt gattacacga tgaggagacg 1264081 aactgccgca ccttctggcg aggccggcac gtctccgtag aggaggtacg agtcccgatg 1264141 gttcaaaaca tgacctatga cgaactcatt ttacgcatca ttattttact gcgagacggg 1264201 aaaatcaggg attttagaag tgttattgat gagcttcagc cctatgacat ggcatttatt 1264261 tttaaagaaa tgccggaaaa acatcgcgcc cgctatttat cttatttaac tgtagacgat 1264321 atcactgata tgatcgggga gctggaacgc gaatttcagc ttgtcgtctt aaataaagtc 1264381 ggaaaaacaa aagcaacact ggcgatgaac aaaatggaca acgatgacct cgctcaattg 1264441 cttgaagaaa tggacgaaga actgaaggaa cagcttttat ccagcatgga agcgtcagaa 1264501 tcaaaagctg tacagctctt gatgaattac ccggctgatt cagcgggacg catgatgaca 1264561 aaccggtatg tgtggatccc tcagcattac acggtaaaag acgcggtcgt caaactgaaa 1264621 agcttcgctg aaatagctga atcgatcaac tacttatatg ttattaatga aagcaaacag 1264681 ctggttgggg ttctttccta ccgcgatttg attctgggtg aacctgaaga aaaggtgcag 1264741 gatttaatgt ttacccgcgt catatcagca gatgctcttc aggaccagga agaagttgcc 1264801 cgcctgatag aacgttacga ttttttggca ataccggttg tagaagaaaa caacgtgctt 1264861 gtcggcattg tgacggttga tgatattatc gacgttgtta ttcgggaagc tgatgaggat 1264921 tacgaaaaat ttgccgcttc cggtaaagac atcacctttg acacaaaagc ttacgtggcg 1264981 gcataccggc gtctgccatg gctgatttta ctcttattta tcggactgat ttcaggaagc 1265041 attatcagct attttgaaga cgcgctgaag caggttgtcg cgcttgcgtt tttcatgccg 1265101 atggtgtcag ggatgacagg aaatacggga acacaatctc ttgcggttgt catcagaggt 1265161 ttgtctaaag aagaaatgaa caaaaaaacg attgtgcgcc tgatcttccg ggagttcaga 1265221 acaagcattt ttatcggagc ggtttgttct gtgctgattg cgattgtttc tatcatatgg 1265281 caggggaatg cgcttttggg atttgttgtc gcctcttcac tgttcttaac cttaatcatc 1265341 ggcacgatgt caggaacgat tatccctatt attttgcaca aactgaaagt agacccggcg 1265401 attgcttctg gaccgctgat tacaacgtta aacgatattt tatctttatt aatctacttt 1265461 ggcattgcca ctgcattcat tcactcatta taaacgtaaa aagtccgtct caactgcgag 1265521 ccggactttt attatttaac ggtttttgta ccgaaagtga gcattaagct gcccctccag 1265581 catttttttc cgcacttgcg gatcgttttt taacatctgt tcttttttgc gcatatcctt 1265641 taaaatctct gccgtctgta cgccgtcttc acgcttattg gcgatatcca tcagccgctc 1265701 cacatcggca aaggagtatt ttcttgtccc ccttgaagaa cgctgcgggt aaatgagctt 1265761 tcgttcctca taatacctga tctgtcttac ggacaatcct gtcaattcac tcacaattcc 1265821 gattgaaatc acttttttgt ctttataaga atgatcttct gtggtcattt ttccacccct 1265881 ggatgtcttt tgataatagt atataaaaaa caaagagaaa aaacctgacg cttgtcatat 1265941 tttctaacat caaatagaag atttttgaaa aaatacggaa gaaaaattaa caagaataat 1266001 gcgtaacacc caagcgcgtt ttatccttta tgtaacgaat caaacgagga ggaaggataa 1266061 tcatggagga agaaaaagca gtctcactgg caaaagaaat tatagagttg gatatcaagc 1266121 gtgatgaaat gctggagacg tttatgcagc ttgccggaga acaggctttt caattattaa 1266181 gatcggttca aaacggacaa taccgaaaat cttcgtaaac ataaattctt tacattagat 1266241 tcataccacg ttcatttaaa aagagtatct tttgtatagg atacctcaaa atgaaggagg 1266301 acgctatgag taatttattg aaatccgctt tagaaaaaga acgacgccat tattctgaaa 1266361 aactctatca gataggggtt tataataaag aggtcatgaa caaaatgacg atttctgagc 1266421 ttcggaaaga atacgcttat ttctttcgaa gcattacaaa tcataaaaat tatccttata 1266481 caagataatg tataaggatt tttttgcttt tagaaggaat ttctcgaatt atagcgaata 1266541 cgtatagtaa gggactgaac tcttattata tgtaagggtt ttcattattt ttttataaaa 1266601 atcctatata cgaggtagat atgatgagat tatcgtttaa cgaagaagaa gttgagcgtg 1266661 cgatgaattt gtacagagtt tttgcaaggg ctttcaaaag tgtgtccgaa catagtatcc 1266721 gtgatagcaa agagcacggt tttaatccca ctgaatttgc tgtactggaa ctcctgtaca 1266781 caagaggccc gcaaaaatta cagcaaattg ggtcgagact tctgcttgta agcggaaacg 1266841 tcacatatgt tattgacaaa ctagaaagaa acgggttttt agtaagggag caggacccga 1266901 aagataaacg ctctgtttac gcacatttaa ctgacaaggg aaatgagtat ttggataaaa 1266961 tttatccgat tcatgcactg cgtattgcga gagcgttttc aggtctttcg cctgatgaac 1267021 aggaccagct gatcgtcctg ctcaagaaag caggcataca cagccagcat ttgctgtttc 1267081 gttaactatt ctacactctc tatttcagga gagtgttttt ttgtttccat atgattcttt 1267141 ttaaaacatc tttaatcttc ctatcagaca tttcgccaag gtatccattg acgtgttttt 1267201 tatactcctt catctgttcg ttcgattgaa aaaatgccgc gatatactct tctgctttct 1267261 gcatgtccca gtttctcata tctgtgacga gtttcctttc atgtagaagg tttaaattca 1267321 tttcctcctg tcccggcagt gcatgataaa taaataccgg aagccgtttc tgtaagcatt 1267381 cactgatggt cacgcctccg ggtttagtca tgatgcctgt cgcctgttcg tacaaacggt 1267441 tcatctctgc tttgctgtga aggtaaggaa tcgcctcaat caaggggtgg tgtaaacttt 1267501 tgacatagga gtagagcttt tcgtttctgc cgcataatat tttgtataag atctttccgc 1267561 ctggcgacag ttcctgcacc cattttaaaa tcccaccgac ccccatactg ccccctgtga 1267621 tgatgatggt atatggcggg tggtgctgca aggtatctgc tgattccatt tcaaaatttt 1267681 ggtgaactgg aatgccggtc aagtatatgt tgttctgatc gataccctct gatattagct 1267741 gcttctttac ttccgtgctc ggaacaaaat ggtaatcaat gttcttccgt ccccataatt 1267801 gattcacgaa aaaatcagtg tatacattca caaccgtcag attcggatat tcaggcttta 1267861 gtcggttcag cagataagaa ggcagcgcat gtgtgcagaa ggcgatatca ggctgttttt 1267921 cttggaggat gtgcctcatt tgctgtgtga acagccattc gtacatgaaa tagcgtttgt 1267981 catgctgaaa ttctccgcag gcgaggagcc tgtaaatgcc gctgtacgtt ttcgggaaat 1268041 attgaatcca ttttaaataa gccacggagg acaatttttc taaccgccta tacgaatgtg 1268101 aaaagatatc aatcttttca gctgccagcc cttgagactc taattcagcc tgcaatgcat 1268161 cagccacatg atgatggccg gtggaaatgc ttaaaaaagg aaaaatgaga atgtttttca 1268221 tgacagtcct cctaaaaaaa tatggcaact atattttgag gagaacgttc acaaaatata 1268281 agggtgtttt tgatcataag gaaggtgaaa agatgaaaac ttgtttcctt tccatatgga 1268341 gagtggttga tccgatttat ttcttttttt caaggctaag cttgattgac aacgatcaaa 1268401 aaagcgtttt tcgagtcagg ctgacgaagt acaaaggaca tcatgtcgtg cttagcgacg 1268461 gaacgcatat aagaaaaaat gatgtgctcg ttaaaatcca cctgcataac ataaagctga 1268521 tcagggagct gcaaagcatt gagagcgcag tcagaaaggg aatcattatt tatcagaaag 1268581 tatatcaatc gatgccgctt cttcttgact atatcaacaa tcataaaaaa agcgagaaaa 1268641 tcaaaggaat cattgggatt acaatgcttg acaaaggtgt ggaaaggctc ggctttgatg 1268701 tgatcacccc ggtgaaccct ttttacagat gctttaaaaa agtgtctcat gtgccgattt 1268761 tatatttgac ttcaaagcct gtgagcttgc ggcatttacc gaattcatcc tatttgttta 1268821 tctcaaaaga aaagctgcag aaaacctatc aaaaaaaaga ctgatgcctc ggtcagcaca 1268881 gtcttttttg attaaatctg atgaaatgtc acttcagggc ggcttccgac acggatattt 1268941 acgccggttt gtcccaagcc ctcgctgata taaaatggtt tatcgtgatg ataatgaagg 1269001 cctttaatca tgttcattcg cacgagcttt cccattttca ccaaatgata cggttttggc 1269061 cagtgaattt gcccgccgtg aaaatgccct gacagcaggt aatcataatg aacatctttc 1269121 atatccagaa taatatttgg gtcatgtgtt aagacaagat gatagccatt ttccagactt 1269181 tgataagagc cggtgatatt actccgattc gtactgtaat catcaatgcc gataatattg 1269241 actggtcctg cagccgtctc gattcgaaca tgttcatttt gcagcgtgat acagccgttt 1269301 tcctctaaaa ctcgcttcaa tctctgaaag tcctcttctt tcaatacata atcgtggtta 1269361 ccgaacaccg cgtacattcc atatgcaggc tttagctttt gcaaggcgtt caagtaacct 1269421 gccagtttcg gaatattacg tttccgatca agaaaatccc cggtaagagc aatgatgtcc 1269481 acaggctgat cttttgttaa atgatacagc tcctcaggtg agactgaaat gttttccaag 1269541 tgaagatcag ataaatgaag gatatttaat ttttttctgg ctggaaggcc gtctttttgg 1269601 tcgattgaaa tggtgttgac tttcacatct tttgtattgc ggttcgcttt atatagaaat 1269661 ggcacaaata cgagtatggc caatgaaagt aagattgtaa acaaaatata tcccctccct 1269721 tctatcagta tagtaagtga tcaagcccta tggatagcgg gaattaatgg gtagagacag 1269781 gttgaaaaac ggattgtcat atgatgaatg atttggaagg gaaaagggat aataaatttt 1269841 gacacatgag gcagaacatg ccgacggagt cagaataaca aatggatgtg taagcaatgt 1269901 tacgattgat gagacaacaa aaaaaagaaa catattatct ctggatcgca ttatttcttc 1269961 ttttattgta tgtatccccg ctttttattt taaaggaaga tgcccatatc cgggtccacg 1270021 ataatttaga ttccaacatc gcttggtaca aggttctggc cgatagcgga gaaatcgtcg 1270081 gcaaggttga cgctgccatt ccgcaaatca ttaacgggct gccccgggat gcctttggca 1270141 ccgagtggag cggaattgtt tggctccatg ctttcttttc ttccatgacc gcctatgcaa 1270201 taagccagac ggttacaaga gttgtcgctt tttttggaat gtatgtgctg ctgaagaaac 1270261 atataatccc ggaaccaaaa gcggctttca tccgaattgg cgtatcgctt gcatttgcct 1270321 taacaccgtt ctggccttcg ggaatgctga gtacgcttgg gtaccctttg gcactgtggg 1270381 cttttttaaa tatccgaaaa ggggatatct catggagaga gtggctgacg ctgggcttgc 1270441 tccctctata ctcaagcttt gttctaggct tcttcttttt cctggcaggg atggcgtgtt 1270501 tttggctgta tgatgccatt acaaaaagaa gatggaattt gatgttctta ggcagtattg 1270561 catttatgac gagtatctat cttttcgttg aatatcggct tgtctattcg atgctgtttg 1270621 agcacgcacc gatgcatcgt atcgaattta tctcatctag gcatgacgtt tggcattctc 1270681 ttcgactatc cataaaaaac tttgtctatg gccataatca tgtgatgacc gttcataccg 1270741 ttgtcatcct tccgatcctg atggtcgtat ttgctgctct gctgttcaaa cgaaatcgga 1270801 caaagccaga aaatgtttat ctgtttttat gtgtgcttaa ttacgggttg tcattatggt 1270861 atgcgttttg gttcaacaaa atttgggctg ttccaaagca gaaatttgct tttttagcag 1270921 aatttaattt tgcccgtttt cattttcttc ggccgcttgt tatatacgtg agctttgcgc 1270981 ttgctttata tctcatttgg cggatgggga aaggatggaa atggcttgtg tacgccgcag 1271041 tcgctgcaca gctgatggtg ttggcgcctt ttaatgaaga atatacgtat ggtgttcatt 1271101 acaacgcgcc gacattcagg gagttttatg catcagagca attcaaagag attaaggaat 1271161 atatcggacg tccgcaagat tcgtataggg tggcgagcat cggactgcat ccgtctatcg 1271221 cccaatataa cgggttttat acgttagata cgtataacaa tctgtatccg ctctcatata 1271281 aatatgaatt tagaaaaatc atcgaaaaag agctggaaaa aaattctcgg ctgaaacaat 1271341 actttgatga atggggcagc cgctgctacc tttttgtcga tgaactcggt aaacgatatg 1271401 atttcaaaaa gaactcgaag aaaacgatca acaaccttca attaaataca gatgtattta 1271461 aaaaaatggg tggacggtac attttttctt cagttccgat catgaatgct gaacaaaacc 1271521 atctcgcgct cgtaaagacg tttgaccata aagattccgc ctggcgcatt tatttatatg 1271581 aaacaagata aggaggatat cgattgaaac agtcacagcc agtattaacc atcgtcgtcc 1271641 cgtgtttcaa tgaagaggaa gtgtttcaag aaacaagcca tcagctgaca gaggttgtag 1271701 atgatttaat tgaagaaaaa ttaattgctg aagacagtaa aattctgttt gtcgatgatg 1271761 gcagcaaaga ccgcacttgg gctttgattg ctatggagag cataagaaac aagaaggtta 1271821 ccggcttaaa attagcctgc aatgtcggcc accaaaaagc gcttttagcc ggattgcata 1271881 aagcgaagaa taggtcagac tgcgtcattt cgatcgatgc tgatcttcag gacgacatct 1271941 ctgtgatccg ggattttatg ctgaaatatc atgagggctg cgagatcgtt tacggtgtac 1272001 gccggagcag aaaaaccgat acctttttca agcgcacgac cgcgttaggg ttttatcgtc 1272061 tcatgaataa acttgggatt aaattaattt ataatcatgc tgattttcgt ttaatgaata 1272121 aaaggtccct tgaagagctt gagcgttatc cggaagcgaa tctgttttta agaggtattg 1272181 tccccatgat cggctttaaa tcggccgaag ttttgtatga ccgcaaggaa cgctttgccg 1272241 gcaaaacgaa atatccgctg aaaaagatgc tatccttcgc ttttaacggg attacttcat 1272301 tcagtgtcgc accaattcga ttctttacgc ttttagggtt tgttttgttt ttcctcagcg 1272361 ctgtggcagg gattggcgcg tttattcaaa agctgctcgg ccatacgaat gcaggctggg 1272421 cgtctcttat catatccatt tggtttttgg gcgggctgca attgatggga attggaatca 1272481 tcggagagta tattggaacg attttttctg aagtgaaaag acggccgaaa tacgcgattg 1272541 atattgattt gtataatgaa cagctgagcc cgcttcagcg ccaggaaaaa gagcggttag 1272601 aaaaaaagta cagttaaaca cggaaagagc tgacttcatt agtcagctct ttttcttcaa 1272661 ctgatgcaat atagcgctaa gcggttcgtc ttgcgggttg cggtaaaaat caaaaaatgg 1272721 gcagccctgc ttcttaattc gatcgatgac cgtatcaatt gtaaacagag cgggtgttaa 1272781 agatgattgc acctcatgcc agtagagcgg ggctgcaaca gtcccaagct catttcctct 1272841 cgttgaatag ggacagataa tcgtttttcc ttctgcatgc tgcaaataat caagatacaa 1272901 tttgcagtgt ctgtttttaa tcaagcgttc agtggtaaag agctcgggaa atgcattggt 1272961 gcagtactct gcgatcagct gcgtaaattg gcgtgtttct tcatacgtaa atgcctcggg 1273021 agacaaggga atataaagct ggatgccttt gttgccggac agcttcgggt acgatgtgat 1273081 gccaaaggaa tccaacagcc gcttcagttc atttgcggcc tgcacggcca taagaaagtc 1273141 atctcgcgaa ggcgggtcta aatcaatgac aatctcagcc ggacgcctgc ttttaatggt 1273201 ttgaaaagga acgtgaaact ccaaagcaag ctggttgcaa agccatagca atgtagacat 1273261 atcctcacag acaatatgtt catggcttcc atcatagaaa gactgaacaa aatccggcgc 1273321 atagtccggc ttgttttttt ggaaaaatga ttcgctccta gatccatgcg gatagcggat 1273381 gacggtgaca gcccggtttt tcagaaatgg gagcaggtag tcactgactt caatcatata 1273441 ctgaataaaa tcttcttttg tttttttatt cttttcaaat atgattttat ccaggcttgt 1273501 gaactggagc tttgggtgaa ccggtttgga gtgtcgtatg acttgcgcat acgtgcattc 1273561 ggtccagtcc atttggaatt cgaaaccgat aaacgatacc tctcttaatg tgccttggag 1273621 aattgttaag tattgaacag ctgcacaaat cgaaggttca agcgtaaatt cgcctgaggg 1273681 tgtttgatgt ccgtgctgtt ccataatctc gcgtatagcg cttttttcct catcacgcat 1273741 tccgtgcgag acagaggcaa tcggtgtcat tattccgttt tttaacaccg ataccgtcag 1273801 aaacccgttg ttagggttga accctgttat gcaaacataa gcttgtttaa agtttttata 1273861 tttgagccaa tcggacgacc gcttcttttc aagccatttg ctgtttgttt tcttcgctac 1273921 aattccttct ccgtcatatt ttattaccat ctcccagagt tgatcaaaat gatcataaca 1273981 gggaatggat tgaatggttt cttttgcgta aggatctgga gatgcaggaa gctttgctgc 1274041 ggatatgagt tcacgcagcg attttttgcg gtccaaatac gaaagaagcg ttacatcttc 1274101 tccgcttcgc tctaacaaat caaaggcgag aaagcagcac ggccgcgcgt ttgccgattc 1274161 ctgaatcttg tctggccttt tcaaacgccc ccgcacttga aggtgttcaa aatctgcacg 1274221 acagggattc accaaacata cgatttcacc gtcaagtgtc agcggaagct ctttttctag 1274281 gtgctgaaag gcagttttgg cgaattgtgt gatttcaggg aaggtgctgc tgagctccac 1274341 accatttctg ctggttaagg tcacacctga agaatggatg cggagaatac agcggtaccc 1274401 atcatatttt acttcgtaac gccattctgc tccgattggc ggtgacgaag ttaagaccgg 1274461 ctgcatggta aacgccatgc gctatgatgt gccggaggct ttttttctag ttgttttttg 1274521 ttttttatct ccggctcctt tcggttcagc ggcttgtgca ggtgcggcag ccggtgtctc 1274581 ccggttcggc cttctggttc tgtcgatgct ggcttgcaga gcgcttacca ggtcaatgac 1274641 atcttcacga ggtggcgctt tatcaggagt gacagccgtt tctttatttt ctagcttgtc 1274701 gttgactctt tgcagcagcg cctgtcggta cgtgtcttca tatttctcag gctcaaactt 1274761 agcagtcagt tcatctatta atgtgatagc agtttgcagt tccttatcgt ttacattcga 1274821 ttgatcaggt acacctggga cttgagcggc gcttctgacc tcatcgggat aatggataga 1274881 ctccatgacg atacaatttt cataaacgcg gagaatcgcc agctgctgct ttgacctgat 1274941 tgtcatattg gcgataccga tctttccggt tgagcgcagc gcctcacgca gcagggtata 1275001 ggccttcgtc ccattatccc cggggccgac aaagtaggag cggttaaaat aaatcggatc 1275061 aatttcctga agctgaacaa agtcaacaat ctcaactgct ttctcctcat gctcctgttt 1275121 taagcttttt aaatcttcgt ctgtcagcac tacatatttt ccttttacat attcatatcc 1275181 cttcacaatt tcatcaggac taagagtttt ttcgcaattt gtgcaaactt tctcgtattt 1275241 gattggtgcg tgatcctctt tatggaggct gcgcagttta atatctttat cttctgtggc 1275301 cgcatatagc ttgatgggga tgtttactaa tccgaagctg atcgatccct tccacattgt 1275361 atgcatatcg ataaacccct ttttttcttt agtgtgaaga gaaggagtac gattcatgtg 1275421 tagtaactta tgggtgaaaa aaagccggcg ctgttattgc gacggctgtt caataatgaa 1275481 ttgttcgaat tgttccggag gtattggcct gctgaaaaag aagccctgca aatggtcgca 1275541 gcctttttca aaaagaagct gcttttgagc tgcattttcc acaccttcgg caatcacctg 1275601 caaagacagc tgatgcccca tggcaataat agctccggta atttgctctg atttaggatg 1275661 ggtctgaata tcgtcaataa atgatttgtc aatcttcagc ctgtgaatcg ggaagtcctt 1275721 caaatagcta agagagctgt gaccagtacc gaaatcgtca atactgattc tgattcctaa 1275781 ttctgttagg gatgacaaaa cctttttgga gtgattgaga ttgtccattg tcatgctttc 1275841 cgtcacctcc acttcaagaa gctgcggagg aagctggtac ttattaagcg tatccttgat 1275901 gaggggaatc agatctttag attgaaactg tctggcggaa atattaatgg cgacagaaag 1275961 atcatagcct ttgtcatgcc aaatccttgc ctgcttgcat gcttcatcta taatccactt 1276021 tccgatatca ataataagtc ccgtttcttc tgcaacaccg atgaattctc cgggcggacg 1276081 cagttgcccg tctggtgtca caaggcgtat cagtgcttct gctcctgtca ttttttgttt 1276141 tttcacactg aattgcggct gataatgcaa gacaaatcta tcgttttcga ttgcttctct 1276201 gagtaccatc tcttggttaa gcttaacggt ttctttgttg ccgattgaaa aagaatagta 1276261 tctgtatttg cttttgtttc gttctttagc cgcatacatc gccatatcag cctttttcat 1276321 caattcaagg ccatccgtcc cgtcttttgg agatatcgca atcccgatac tgacagatgt 1276381 gacaagggtg tgatcttgaa ttttgaaagg ttttttgaat ttttggataa tttttcttgc 1276441 taaaacatct gcttcgcctg ttcctgtatt ggcgtctgtt aatataataa taaattcatc 1276501 accgccaaga cgggcgataa atccgttatc agggactaca gatgacaggc gtttagctgc 1276561 aaactgaagc aattgatcac cgacattatg ccctaatgca tcgttaatca ctttaaaccg 1276621 gtttaagtca agaaagaata caacagtgtt ataatgcaag gaatgctcgc gattcagcac 1276681 ctttgttaga tgagagatgg catgccttct gttaggtaag tctgtaagcg aatcataatg 1276741 agccattcta tggatttctt tttctgcttt gtactgcttc gtcatgtctt tacaaatgac 1276801 ataaatgctg tctagttcct gattgacctc aacaggtata agcgtaatat ttaagtgaaa 1276861 ctggcctttt tcagtgataa gatcgctatc gctgttcatc gcttgtttat cttttttaac 1276921 ttgctcaaaa aggcgcttaa ccttcagtga tgtgtaattc ctccagtcat gcatgctgaa 1276981 gccaaatttg ctgatcattt cctcaccagc gtgattggaa gatattatgt ctccttctaa 1277041 tgataaaata aaaattgcat caatattgtg gacgattaaa gactgaaatc gctgttcgtt 1277101 atcctttatg cgttcgctct gtttaataaa ctttcgatct gcatgggaac tgaataacaa 1277161 taacgtttgg atacaaaaaa taattaaagt aacaaaaatt gaccaatgaa acgtttgcac 1277221 ctccatatgg cttccgggcg gagccatgtc cttatggaaa gttgccgcaa gcatccctgt 1277281 gtagtgcatg cccgaaatcc caatgcccat tacaattgaa ctgacgcctt tatagaatat 1277341 aagatgctca gaatgttttt ttacggccaa gtcaaagaat atttttaacg agacgaaaga 1277401 ggctgcaatc gcaatgataa ttgaaactgt aaataaaata ggttcgtaaa taatcattac 1277461 ccgggaaatg gcagacattc cgatatagtg catagaagca atagatgcgc caagcacaac 1277521 tgatccggta agcagtctgt aatatgtaag aatgtgccgg ctgacaaaat ataatgacac 1277581 aaatgatccc gaaacagatg cgccaatggc tgccattaaa ggcatgaatt catattccat 1277641 cggcatttcc atatggacgg ccatcatccc tacaaaatgc attgaccaaa taccgaatcc 1277701 cataataagt gagccgccga tcagccaaat tttacttttt aagcctgtat tgatggtgac 1277761 tttccttgaa agttcaaggg aaatatacga ggcggtacag gcaattagaa tagataaaca 1277821 tatgagagtc gtattatatg taacgtgtat ttccaaatgg agattccccc cgtatcgtgt 1277881 gttccagtct tgttgactct ctttattatc ggctgcttaa ccgcagagtt tcagccttca 1277941 aaacgataga aatacgaggg agatctattt ttagttcaac tgaccgtgaa aaatgtgtta 1278001 aaatcatctt gatgttttcc gaaaagagaa aaatgtatga tacataaaca tgaaacaagg 1278061 gagttggtgg ctatcgaaga gctggttatg tcatggattg aagcatttaa aagcttatct 1278121 tattttggaa tatttctagc gctcagcatt gagtttattc cggccgaagt cgtcttgccg 1278181 cttgcgggct attgggtatc taaaggcgat atgacacttg ctggcgttgt tttggcagga 1278241 tcgcttggag gagtggccgg tccgcttacg ctgtattgga taggccggta cggaggaagg 1278301 ccgtttcttg aacgttttgg gaagtatctc tttattaaac ctgaagcgct tgataagtca 1278361 gataattttt tcaaaaaaca tgggggcttt gtcgccttca gcggccgttt cttgcctggt 1278421 atcaggacat tgatttccat accgtgcgga attgcaaaaa tgaatgtttg ggtgttttcg 1278481 ctttatacat tcattgctat gcttccgatt acatttgtat atgtttatct cggtgtgaag 1278541 ctcggtgaaa attggaaggc agtcggctct attcttgatc aatatatgct tccgatcggg 1278601 atagcgattt tggcgctgtt cctgctctac ttactgatga aaaagaggaa gaaacgcacg 1278661 cactccgaac aattatctgt atttttgaaa aataaacgtt gacaaatcac tgcgctgcgc 1278721 atattattga cgtataaaat catatttctt gaaatcccaa aggggagtag cgtccggaat 1278781 gtattccgga aacaaagtcg tcatttcatg gattgtatcc atcggctttg ttggcatgcc 1278841 tgaattcatg tctagcaaga cctttgcctt atgtcggcaa aggtcttttt tgcatggtcc 1278901 ggccggcata agatcggatg aagagaaaga aaacaacttt tttgggaggg tatcatttat 1278961 ggatgcagca ttattattag agtatggttg ggttcttctc gtcttgatcg ggctggaagg 1279021 gattttagcc gccgataacg cgctggttat ggcggtaatg gtaaaacatt tgccggagga 1279081 aaaaagaaaa aaagcgttat tttatggatt ggcaggggct tttgttctgc gatttggctc 1279141 tttatttgca atttctttct tggtcaacgt atggcaggtt caagcgattg gcgcgatcta 1279201 tttgctgtat atctcagcaa gccacttatt gaaaagatat gtatttaaga aagaagacac 1279261 acataaagag acgaagcaaa gcggtttttg gccgactgtt ttaaaagttg aactggcaga 1279321 tatcgcgttt gctgttgatt ccatcttagc agcagtagcg ctggcggtta cacttcctgg 1279381 gacatcactc ccgaagatcg gcggacttga cggaggacaa tttctcgtca ttttggccgg 1279441 cggtatcatc ggactggtga tcatgcggtt tgcggcttcc atgtttgtga agttattaaa 1279501 ggaacgtcca agcctagaaa cagcagcctt tgtgattgtc ggctgggtcg gagtgaagct 1279561 tgctttatat acgcttgccc atcgcgacat agcggttgtt tctgagcact ttatccattc 1279621 tggaacatgg aagctgatat tctggggtgt cttagcagca atcgcggttt gcggctggtt 1279681 tatgtcaggt gggaaaaaac agccggaggg tgcacaaaac gaacaaaaaa acagcacccg 1279741 tgaacgggcg taatctgaaa gactctgctt aaaagcagag tctttttgtg tttgaagcgt 1279801 tttcataagc gaaataaaat aacattttta taacatcttt gttacaaaaa acacgcataa 1279861 aaccccctta attctttaga aaggcacgaa atcatgtata gaacgtcaga atggtttgtc 1279921 ataattgaga cattggaaat caatatttct ttttctcctt tgcgaatccc tatcaaatta 1279981 gctatcatta atgagtagtt atagggagga actgaggtga aaccagtgct tagccttttg 1280041 tttaaattgg gaaaaaagaa gcaaacactt gaaaaagctg ttgagagtat acaaaaaggc 1280101 aataaagatc tgcaaaatga attaatacag caatataagc catttatcgc aaagacggtt 1280161 tcatccgttt gtaaacgata tatagatgaa aaagacgatg agttcagtat tggactgatc 1280221 gcgtttaatg aagctataga aaaatattca cctgaaaaag gaaattctct gctcgcattt 1280281 gctgagctta ttataaaaag aaaagtcatt gattacatta gaaaagaagc cagaagcgca 1280341 caaaatataa atatcgattt acaggaagga gacgatcagg agtcatcaca aagcctgatt 1280401 gaagccgagc tttccattga tgaataccgc cgtcagattg aacaggagca gaggcgggag 1280461 gaaatcctct attttcaaaa gcagctcaag gattatggtt tatcgtttaa agaactgctt 1280521 gaaaattctc caaaacacac ggatgcaagg caaaacgcca taaaggtggc aatgacgctt 1280581 gttgaacatg aagaattggc cgctatcctg tatacaaaga agcagcttcc ggtcaaacag 1280641 cttgaacagc ttgtctctgt aagccgaaaa acgattgaga gaaacagaaa atatattatt 1280701 gcgatgtgta ttatcattac gggtgattat atttatttaa aagattatct taaaggggtg 1280761 ctgcactcat gagaagaggg attatagtag agaaaaataa aaaattcgtc acgttgctga 1280821 cccctgacgg acaattttta aaagccaaaa atgatcgaca cagctatgaa atcggagaag 1280881 aaatcatgct tccgagtgaa acacgcatgg gcagaagggc cagctttttt gattttttta 1280941 aactgcgccc tttcaaaatg gggattttta cgatgactgc tattatgctc tttattttta 1281001 tagttctccc cgttttttct aataataagg cctatgcgta tatgacaatc gatatcaatc 1281061 caagcgtcga aatggcgtta aacagcgatt atgaagtgat tgaactgacg cctctaaacg 1281121 atgagggaca gaaagtcgtg aatgatatag atgattggga gaagactgat tttaaaaagg 1281181 tgattgacga tattataacc gactgcagtg aacacgggta tgtaaaaaaa tcgaaagaaa 1281241 tattgatttc cactgtttat gaaaacacag aagacaatac atataaaaag gctgtgaaaa 1281301 aacagctgaa tgatgtgact gaaaaatata aaacgacata ccgcatggaa tctctcgagt 1281361 cagatatgca aacgagggaa aaagcgaaga aagaaggcgt ctcaacaggc agctacatca 1281421 aatcaaatga aaagaatgac aataaagata taaaagatga ctccagcaaa ccatccgggg 1281481 aagaggatca aaagagtgat gaaaatgagg atgaaaacac cgatcaaact gacacccagg 1281541 acagcaagca aggagataat gaacagctga atgatgcgga ttccggagac cagaaagaag 1281601 agaaagcgga tgaccagatt gatgatagtg acaaagataa aaaaataaag gaatcagatg 1281661 aaaacacaaa taccgaaaaa gatggggacc atgagcaaac cccaatacaa gatcctcaag 1281721 ataaaggaaa tgaaaataac ggcgctgaca agggccaaag ccaatatcac agggactgga 1281781 acaatggtga acaaggcaag aaccgttctt cgtccagaag ggataacgct tcagaccgac 1281841 gtaatccaaa cggctacagc agtgataatc attcagctaa aaatgaagat tcgccgagtg 1281901 cccccggcga ataaagacct gaatttattt agttgtgcca tttaattgtg attgtgcttg 1281961 ctgtaccagc cgctttgtca tttctccgcc tacagagccg ttagcgcgtg cgactgtatc 1282021 agaaccaagg ttcacaccga attcttgagc cacttcgagt ttaaattggt ctagtgcctg 1282081 ctccacccct ggaacaacga gtttatttct gctcgccatc tttttcatct cctttttcga 1282141 taaagaaatt cttaacgcgt atttagtttg aaatatacgg ggtttattta tgctggcaat 1282201 tgttgtggag aaaaataaaa ccccggcctc tgagccgggg tggcgcagac tatagaatgt 1282261 ctgctgtcat tttatgtgcg gttgcctgaa tatggaatgt caaaatggag aggactgtaa 1282321 tggcgataat ctgtctgatt ttaagccatt ggctgtcatt cagttcttca aaacggtgac 1282381 ggagacgctc tgtctcctgt tcggcgatct cctgcagatt tgattctttc atagaaggag 1282441 tatcttggtg atggatggca tcaagcacat atgcgcagct ttcataataa gcaatcgggc 1282501 tgatgacatc atcagatctg tctgagattg tgttaaaggc cacttttaaa atagcccgta 1282561 tgtgttcaaa gtcataaatg gattttaaat cacgtacaat taaaagaata actgcctgtt 1282621 caattgagta ttttttgccc agctcagggt gtccgatcag atctttgata tcacgcttta 1282681 cccagttttg aatcgcggtt gactttaacg aagtcagctc gcataagttg ccaagctcta 1282741 cgatttcatt tgtagacaga ccgtattctt ttttctgttt ttttcgttcg tatcttgtaa 1282801 gaaattcagg aatttctaga tgattggctg ctttttctgc tgacatgttc gctgattgga 1282861 cgagaatgtc gagcgggcta tgttctcctt gtccttttag ggaatagagc agccgcacca 1282921 tatcggttcg agagagttta aaaatgttca ttgttcacct ctttaaacaa tttgacgcgg 1282981 atataggtct atgtataagt tcaaaattca agcgtcagca aattacatta acatcatacg 1283041 tcgaattcct tgcattttca aatggatgtt ttataattta aatatacggg ttcttttgaa 1283101 cttaaaataa cggaggttgt tatggcgaaa agaatttttc tgtttattct aacgaatatt 1283161 ttggtgctta caacaatcgg gatcgttttg tctgttttaa gctctgttac aggagtcggg 1283221 acgtacttta cagctgatgg cggtatcgat ccaatggcgc ttcttgtgtt cagtttagtc 1283281 gttggatttg tcggttcctt tacgtctctt gcgatatcca gatggatggc aaagacgatg 1283341 atgggcgtca gagtgctgaa tccgaaaaaa cactcgctca gctatgagga acagcaattg 1283401 gttgatcgtg ttcacagatt aagccgctct gccggtttaa cgaaaatgcc ggaagtcggg 1283461 atttaccgtt cacctgaagt aaacgcgttt gcgactggac cgtcaaaacg ccgttcactt 1283521 gtcgcagtat cgtcagggct gctggagcag atggatgacg cagcagttga aggtgtgctt 1283581 gcccacgagg tcgcgcatat cacaaatggt gatatggtaa caatgacgct tttacaaggt 1283641 atcgttaata cctttgtcgt ctttttatcg cgtatcgccg cttggatagc aagccgtttt 1283701 gtcaaagaag atctagcgcc gatcgttcat tttattgcaa tgattatttt tcagattgtc 1283761 ttttcgatac ttggcagcct ggttgtgttt gcgtattcac gccatcgtga attccatgct 1283821 gacaggggag gagcggatct tgccggcaag gacaagatga ttcatgcgct gcggacgctt 1283881 aaaagctatt cttcccggat tttggaagac gatcagacag ctgtccaaac gttaaagatt 1283941 aatggcaaga agcgctcttc acttttctct actcatcctg atttagatga gcgaatcaga 1284001 cggctggaag ctaaataata caaacacatt gttcctctga gagaattctc agaggttttt 1284061 tattttatcc attgactaaa atcataaaaa aataagcaag ttaagaaaat gtttcgtaaa 1284121 agcctttaaa aatggaccta atatctttag aataattacc gtacttaaaa agagaggcag 1284181 aaggatttta catgagatta aagtttggaa aattgataca ggccttgtca ccggcccagc 1284241 tgatcgcatt atattatttt cttgcagtta ctgtggccgt tatattgctg agtttgccgg 1284301 cggcccataa accgggggcg gattggacgt ttattgatgc gctttttaca gctgtcagtt 1284361 cagtcagtgt aacggggctg acagttgttg atacagctga tacattcagc acaataggga 1284421 tttttatatt agcatttgtt ctgcaatttg gcggaatcgg aattatgacg ctcggaacgt 1284481 tcatttggct gatcatggga aaacgaatcg ggctgaaaga acggaagctg attatggttg 1284541 atcaaaacca atcccagttt tcaggaattg tcaatctgat gaagcaggta ctgtttctga 1284601 tcttgtggat tgaatttttt ggcgggctga tactcggcac atatttctta acctactatg 1284661 actcctatca ggaagcctat ttacacggat tttttgccag tatcagtgca acgacaaacg 1284721 gcggatttga tattaccggt aattcgatga ttccatttcg ccacgattac tttgtgcagt 1284781 ttattacaat gcttttaatt atatttggag cgattggatt tcccgtgctt gttgaagtaa 1284841 aggatttcct gttttcaaag catcggcgtt atccatttac gctttttaca aagatcacga 1284901 cgattacgtt cggctcactt gtcttgtttg gagccattgg catctttgcc ctggaagcaa 1284961 accatgcgtt cgcaggaaaa tcatggcatg atattttgtt tttgtccctg tttcaatcaa 1285021 cggcaacccg aagcgggggg ctggcaacaa tcgatatcag ccaattatca gattccacac 1285081 tcttttttat ttgtgcgctg atgtttattg gagcgtcgcc aagctcagtc gggggaggca 1285141 taaggacaac gacttttgct ttgaaccttc ttgcgctgtt tcattttgcc cgcggcaata 1285201 aggccgtaaa ggtattcaaa cgggagcttc accctgctga cttgatgaag tcgcttgttg 1285261 tcacgatgat ggcgatcctg ctcgtttttg gcgcgacact cattctgacc attacagaaa 1285321 aacattccct gctggagctt ttgtttgaag tgtgctcggc attcggtaca accggcctat 1285381 cgcttggaat tacggcagat ttgagcagtg ttggaaaatg cgtcattatg attgtcatgt 1285441 ttatcgggcg aatcggcatc ttgaccttcc tgtatctgat cggaagaaag gaaattgaag 1285501 cgaattatca ctatccgaag gaaagagtga ttatcggata ggcaaaacac cgcatatttt 1285561 gcggtgtttt ttgattacca aaaaaaagat gtgtgcctcc tgttcagttg gagaacctaa 1285621 ctccgacagg tgcaatttac gctcctgcat cttaaaatgt ctgaaaattg gcgaggagga 1285681 ttcgtatgaa gcgtaaagct gaagtgaatg aagccattaa aaataacaat acacctaccg 1285741 agagcatgga ccccaattca tataagacac aatatcatga cgaccccaat tttagagggg 1285801 caaaccgcaa ttccaaacag ggccagcagg gaggcatgta attgtgaaga aaaaccgtca 1285861 tagcagagac atgcaaaatc ataaaaagcc tatgaataaa aaggtgctgg aggaagaatt 1285921 ctcaagtgaa ctcggggatt acaatgccgg aaagatcatc gaaacgctgg aagtcaccaa 1285981 gcctgaaaag aaaaaagaaa aaaacaaaaa acaacaataa aaaagacctc ttaggcggcg 1286041 tcccgcttaa gaggtgcttt ttctatttta aataagcatt tttgcccgtt cctctgacaa 1286101 attgcaataa gcttgtcatc ctcagctcaa tgaatggctg agcgactgtc ttaacaaagt 1286161 tgctggagag gactgatgtc agggctgctg ttaaaagcaa gaggatcact aagctttgat 1286221 agtcagtaag ccaatcctca agcccgacct gccgtaatgt cttaataata aacccgtgaa 1286281 gcagatacac gtaaaatgtc cgggttcccc atttggtaaa gaaataccgt ttttgcggaa 1286341 cgagcgctaa aaagctgaag gttgccccaa aggcgagtac ataccagccg attcgggata 1286401 gtccgcttac cagggtaacg tctccaaatg aagaatacgg ttttgaacca aacagaaaag 1286461 aatagtcaaa atcgatgccc cagcagatga cgaatactgc ggcaagcact ccgagcgcaa 1286521 tttgtttgcc gcgttttgat ctcaataaat caaaatgatg tttatttaaa taaaaaccga 1286581 caaggaacat cggtaagaat acgaatgtcc gtgacaagct cagcgtgctg ctgacaaagt 1286641 ccagataacc gatcagcacg gcgattccgc agctgacaaa cagcgcccac tgctttgaaa 1286701 gctttgaaaa aggatatagg agcaggttcc aaaagaataa gcttacaaga aaccataacg 1286761 accattgcgg atcaatcggg ttcacatttg ccatgctttc atcttgcata atgtaataaa 1286821 agacggaata aataatttgg aaaatcaaat acggaataat cagcttgacc gccagctttt 1286881 ttacatatcc cgcccgttta aagcctttcg cgaaataacc ggatacaaga ataaatgcag 1286941 gcatatggaa tgtgtaaatg aacttgtaga ggtagagcat aaaatgatta tcattaataa 1287001 aggaacgaag gatatgaccg aatacaacaa ggaatatcaa taaaaatttt gcgttatcga 1287061 aataactgtc ccgcgattta ctcatagcat caccttctct ttcatcagtc actaagagat 1287121 tattccctgc tggtacatat tttaaaataa aagatgaaaa aggaatctaa aaaaatgctg 1287181 attgttaggt cgatgtaaag tgacggtaag gatcgtagaa aatgtcttcg taatgtaatg 1287241 acgctgaaat tttctgaaat ttatagggca aatgaaggaa gttcccgcat tttgtagaaa 1287301 tattgaggga taggttttga agaaggagtg tacatgcatg gaaactcttg gtgtccagac 1287361 aaactcggag ctgcgagagg aactgaatcg cctcaaagaa gaaaacgcgc gactgaaaaa 1287421 ggaattgaat cagcatcaag tgattgtcaa caatacgctc gatgctattt ttatttgtga 1287481 taacgaaatg cggattgttc aggcaaatga agcaacagaa aggatgcttc aagttgactc 1287541 ggaagatttg aaaaagcgtt ctgttttgga ttttttgttt tcaatcccaa aggatgaact 1287601 gaatctttcc gtaaagaagt tttttaaaaa aggctttctg tggaaggagg ttccgatcag 1287661 gcttgattgc ggggcaacaa aatacataga gtttctggcc aaaagaggta ttggtgagga 1287721 tttctttttt gttgtcatga gggacatatc ttctaagaag attctggagc gggaattctc 1287781 tatgaatgaa cagcttttta aggacttgtt tgacagagca gttgacggaa tcgtcctgtt 1287841 tgataaagat ggcggtttta ttgatgcaaa tttgtccttt tgtaaaagct ttgaaatcaa 1287901 tcataatgag ctgtctcatt tatctttgta tgagttcata gacagcggct cacgaaaaga 1287961 tttcgacaat atctggaagg cgctcaaccg caagggaaaa gcgaaggggg agctgcctgt 1288021 caagcttcgt tcaggagttc aaaaactatt tgaattcacg attacatcaa acatcatcag 1288081 cggtttttat atgtccatta tgagggatat cacagagaag cggtctatgg agctgcagct 1288141 ctttaaaagt gaggagcgct tcagagaaat ctttgaaaat gcaatggacg ccatcatcat 1288201 ctggtcgaat gacggaagaa tcgtaaaagc gaatcaatca gcctgtaaaa tttttgagct 1288261 gccgatgaat ttgctgttga aaagaaagct gtgtgatttt ctcgttgact cgcagcagaa 1288321 atacagcata acgaagagga aatacgcaaa atacggagag atcagagaag agctgctgtt 1288381 tcaaatgggg aacggccaat tcaaagagct tgaatttact tcaaaacgga caatccttga 1288441 aaatcagcat ttgacgatct taagaaatgt aagcgacaga aagcggatgg aaaaggagct 1288501 tcgggaaagc gagctgaaat tcagaaaagt gttcaacgga tcaatggacg gcaatgtatt 1288561 gttcgacaat caatacagga tcatcgacgc caacccgtta gcaagccata ttttgggcct 1288621 gtcacatgaa gagatcaaac agcacagcct gttagatatt atttctgctt atgaaataga 1288681 aaatttggca tcaccggcaa ggcagattaa ttttgatgaa atggacaacg aaattccatt 1288741 tttgctgagc agcggtgata acagaaaact cgaattctca tttaaacgga atattattca 1288801 aaatatgaac ttggctatct ttaaagacgt aacagagcga aaagaattgg aggagcgcct 1288861 gcgcaaatca gatacccttc atgttgtcgg cgaactcgca gccggtattg ctcatgaaat 1288921 cagaaatccg atgactgctc ttaaaggctt cattcagctt ctgaaaggga gtgtcgaggg 1288981 agactacgcc ctttacttca acgtgatcac ctcagaacta aagcgcatcg aatccatcat 1289041 caccgaattc ttgattttag ccaagcccca ggccattatg tatgaggaaa aacatgttac 1289101 ccaaattatg agggacacga tagaccttct aaatgcgcaa gccaatctca gcaatgtaca 1289161 aatgcaactt gatttaattg acgacattcc cccgatttac tgtgaaccga atcagctgaa 1289221 acaggttttt atcaatatat taaaaaacgc catcgaagtg atgcctgacg gcggaaatat 1289281 ttttgtaacg ataaaggcat tggatcaaga tcatgttcta atctccttaa aagacgaggg 1289341 aatcggaatg acagaagata aattaaagcg acttggtgaa ccgttttata cgacaaagga 1289401 acggggaact ggacttgggc ttatggtaag ctataaaatt attgaagaac atcaaggcga 1289461 gattatggta gaaagtgaag aagggaaggg caccgttttc catattacgc ttcctgtcag 1289521 acagaatgct gaagaaagaa ggaatgatga atgaactact atacgacagc cgaaacgccg 1289581 ctcggtgaac ttatcattgc cgaagaggag gaccggatca ctcgtctatt tctcagtcag 1289641 gaagattggg tggattggaa agaaacggtt cagaatactg agcataagga aacacctaat 1289701 cttgcagaag cgaaacaaca gcttcaagaa tatttcgcag gcgaaaggaa gacattctcc 1289761 ctgccgctca gccaaaaggg cactcctttt cagcaaaaag tgtggcaagc gctggagagg 1289821 attccatatg gcgaatcccg aagctatgcg gatattgccg ctgctgtcgg cagtccgaaa 1289881 gcggtgcgcg ctgtcgggca ggctaataaa cgtaacgacc tgccgatttt tgtcccgtgc 1289941 cacagagtga tcggcaaaaa cagtgcgtta acaggatacg ccggaagcaa aacggagatc 1290001 aaagcatttt tgctaaacat cgagcgaatc tcctataaag aaaaataaaa catatggcac 1290061 gttccctttt ttcacggccg acatatcatt ttattaagtt aaaaaagttg gtctgatgaa 1290121 aaaggaggac aaagcaattg aagccgagcc gctctgagaa acttgccgtt tttgccgaac 1290181 tgtttgtgaa actgcatatc ttatcaagcg ctcaaaaaga tgaaatcatc aatgttaaca 1290241 aaaagaaaca aaaaaaccgc tgactcggct ccaaatgagc aaagtccagc ggttttttaa 1290301 tgcacctttt ctcctttaaa cagctgttca atctcttctt catagtttcc ggtcataatc 1290361 cctttttctg tgatgattcc tgaaatgaga tcatgaggtg taatgtcgaa agcgggatta 1290421 aagacaggca cattggatgg agcggtccga actccggaaa tctgcctgac ttcctcggga 1290481 tctcgttcct ctatcgggat atcagcgccg catttgacct ttgtatcaaa tgtagataaa 1290541 ggtgcggcga caaaaaacgg aatatcaaag gcgtttgcta aaatagcaag accgtatgtg 1290601 ccgattttat ttgccgtatc accgttcttt gcaattcggt cggctccgac gataacagcg 1290661 gaaatttgtt tttccttcat cgtatgggcg gccatgctgt ctgtgatcag agtgacatca 1290721 atgcccccct gcatcagctc ccaagcagta aggcgtgaac cttgcaggac aggccttgtt 1290781 tcacaggcat aaatgtgtaa tcccaaatct ttttgtttgg ccaagtaaaa cggagctagc 1290841 gccgttccat agcggcttgt cgcgattgag ccggcattgc agatcgtcat gatcctgtcg 1290901 ccttttttga aaagctgcag ggcgttttgg ccgatcaacc ggcacgtttc ctcatcctcg 1290961 acctgaatct gaatggcttc atggacaagg tttgtttttg cttcatttac ggaaatcgcg 1291021 ttttcgaccg aatgactcag tctctcaagc gcccatgaca aattaatggc ggtaggccgt 1291081 gagctgttta aatattgttt gatgtcttcc agtctgcggc ggaattccgt gacattgtct 1291141 gtttcaatgt ctttggcagc aagcgccagt ccgaaggcag ctgtaatgcc gatcgccgga 1291201 gcgcccctta ctttgagcgt gacaatcgca tcaaatacat cctctttcgt cgtcagctcc 1291261 aaatattccg tctcatcagg aagcttttgc tgatttaaaa tggtaatagc tgtttctttc 1291321 cattcaacag aacgtggaac agcaaatgaa tgggtcatga atagatcatt cctttacaag 1291381 taacttaaat aattcaataa catctgttat cgttttgaat tccgaacgtt tttcgataaa 1291441 ggctgtgccg gtttcgagcg ccaagcgttt tctgccgatt cgtttatcaa acggcacgat 1291501 cgtatccagg tcagctacat gggcaaggcc gatcgtgcgt cgtatcagct cacagcccgc 1291561 aaatccgatt gcttcttcaa aaatatggct gagcgtatca gtgaggtaac cgtcgatgtt 1291621 ggcgtaaaca tccagactgt ccttctgcca ggcttcacta aacgtctctt caaacgtttc 1291681 ccagacctgg ttgacatgtt catataacgg ctctctgtca gccccgtcac ggctgagtgc 1291741 gttcaaaaat aagttggcga taaattgccc tacatcaaag ccgatcggtc cgtaaaaagc 1291801 aaactcagga tcaatcacct ttgtttcgtg ctcacttgcg aaaatgcttc ctgtatgcaa 1291861 atcaccatga atcaacgttt ctgcagacgt taaaaatgac tttttcagct tagcggcttc 1291921 gattttaacg ctgtcattat tccaaagctt ttcgacaaaa ggacgaagct cttcttcaaa 1291981 atcatttgtg tcatggtcga agaaaggatc tgtaaaaaca agtctttccg taatgtcgca 1292041 tagctctgga tttgtaaact gtttaacaag ctgttttttc accttaggtt caagcgcgta 1292101 atctgatgag tagaaaagtg tttttcctaa aaattcaccg atgtgctgcg acagatgagg 1292161 atagttttca ccctcaatga gtccttttct tgcgatcttg aggtgagaga gatcctccat 1292221 gacggtaacc gccatttccg tatcagaata aaacactctt ggaaccaggt gaggcacatg 1292281 ctcgccctga cggatgagag cgctgctttc gattcttgca cggtcgattg tcagcggcca 1292341 gctttctccc accacttttg catacggaac cgcctgttta atgatcaatg ctctgtcatg 1292401 ttcttgatca taaatatgaa aaacgtaatt taagttgccg tctccgatct cctggcatgt 1292461 cagcgtgctt ttgcttggaa ataggccaag cttcaccgcc aacgccacag cggagctttc 1292521 atttaacgtt tcgtataaag gtgtttttgt gactcccatc atcataacct ccaattatgt 1292581 aattaattaa tatgtggccg taaaaaagcc tccttctcag agagaaggag gcttaacatc 1292641 tatgtccgcc tctcttatct ctcagatcag atctgaatgg aattagcacc gtgccttaag 1292701 agaccagcgt ctcggcgcga aaaaaatgcg ccccatttca caatggaatt acggtcggtt 1292761 gcttttgggg tcaaaaggcc aaatccctcg cccaactctc gataagagaa tatattcact 1292821 tgtttgacaa ttctaattta tcagttgatg aacatggtaa caggtaattt agttagttgt 1292881 caatatattt tttaatataa atcttttctg atatcatcga aaacaggaat gctctcccga 1292941 acttctgcgc tttcttgaag gtcgatttcc gctcggacta tgccttcttc ccggccgcct 1293001 tcagcaagta cacgtcccca tggatcaata atcaggctat gtcctgcaaa ttcattatcc 1293061 ggatttgaac cggtacaatt gcaggctgcg acaaagcatt ggttttcaat ggcccgcgca 1293121 ataagcaggc ttttccaatg atcaaggcgg ggaagaggcc attccgcaga aataaacagc 1293181 acgttggcgc cttttgtcgt atgttttctg atccattccg gaaaacggat atcgtaacag 1293241 atcaatccag agcttttgac gccgtcaagc tcaaagtatc cgtcttcgga accggctgat 1293301 aaatacagat gctcatccat cagctgaaaa agatgggctt ttctgtactc tttaatgatt 1293361 tgcccttcct tatccgcgat gtacattgta ttataaacat cagaattctt cctgacagcg 1293421 accgatccgg cgacaatatg aacaccatgt ttttttgccg ttttcttcag ccagctctga 1293481 gcggagcggc cgtcttcgtc agcgagttca tcaagattgg ccagatcata tccggtcgtc 1293541 cataattcag gcagaacaag aacatcagca tgtttgcttt ctttttcgat gaaaaattca 1293601 gcctttttta tattttccga aggttttccg tatgaaatat caaattgaag acaagatatc 1293661 gtccatttca tctttttaac accccaaatt tttctttact tttttcattt aaccatatat 1293721 gatgatggac tatcatttca agattttttt agaaggtgag aatagatgaa atttgaacag 1293781 tctcatgtat tgaaggaatt gcctaaacaa ttcttcgctt ctctggtgca gaaagtgaac 1293841 cgaaagcttg cagaaggaca tgacgttatc aatctgggac agggaaatcc agatcagccg 1293901 actcctgagc atattgttga ggagatgaaa cgagctgtcg ctgatcctga gaatcataaa 1293961 tattcgtctt ttcgcggctc ataccgtctg aagtcagcgg ctgctgcatt ttacaaaaga 1294021 gaatacggca ttgatctgga tccggaaacc gaagtcgctg tattattcgg cggaaaagcc 1294081 ggtctagtcg agctcccgca atgcttgttg aatcccggtg atacgatttt agttcccgat 1294141 ccgggttatc ctgattactg gtcgggtgtc acacttgcaa aagcaaagat ggaaatgatg 1294201 ccgctcgtaa aggacagagc gtttctccct gattacagca gcataaccgc tgaaataagg 1294261 gaacaggcga aattgatgta tttgaattat ccgaataatc cgactggagc tgttgctact 1294321 tccgagttct ttgaagatac cgtgcgtttt gcggctgaaa acggaatctg cgtcgttcac 1294381 gattttgctt acggcgctgt aggatttgac ggctgcaagc ctttaagctt tttgcagact 1294441 gaaggtgcga aggatatcgg aattgaaatt tacacgctgt caaaaacgta taatatggca 1294501 ggatggcggg ttggctttgc cgtcggaaac gcttcggtca ttgaagcgat caatctttat 1294561 caagaccata tgtttgtcag tcttttcaga gcgactcagg aggctgcagc agaggcactg 1294621 ttagccgatc agacgtgtgt ggcagagcaa aatgccaggt atgagagcag gagaaacgct 1294681 tggatcacgg catgccggga aatcggctgg gatgtaacag ctcccgcagg ttcttttttt 1294741 gcatggctgc ctgtgcctga aggctatact tctgagcagt tctcagatct tttgctggaa 1294801 aaagcgaatg tggcagttgc ggctggaaac ggcttcggtg aatatggcga gggctacgtc 1294861 agagtcggac ttttaacaag tgaagaaaga cttaaggaag ccgcttatcg aattggcaaa 1294921 ctgaacctgt ttacccaaaa aagcattgac aagaccttat aacgatggga taattcaaaa 1294981 taatttataa aatctatatt ttcttatcaa gagcaggcag agggacgagc ccgatgaagc 1295041 ccggcaaccg acttataaag cacggtgcta attcttgcag ctagcggctg agagataaga 1295101 ttcggacgag aaacgaaacc tctttagacg cgattgcagt ttgaagaggt tttttgatat 1295161 ggatgaaaat gaaaggagct ctggcatgag tgagttatta gcgacatatc tcctgaccga 1295221 accgggagcc gatacagaga agaaagcaga acaaatcgca acaggattga cagtaggctc 1295281 ctggactgat ctgccccttg taaaacagga gcaaatgcaa aagcacaagg ggcgggtgat 1295341 aaaagttgag gagagagagg gaactgctgc atcagaaaaa caagcggtca tcacaattgc 1295401 ctatcctgaa atcaatttct ctcaggatat tccggctttg ctgacaacag tgtttggcaa 1295461 gctgtccctg gacggaaaaa tcaaattaat cgatcttcac ttctctgaag catttaagcg 1295521 tgcactgccg ggaccgaagt ttggcgtata cggcatccgg aagctgctgg gagagtttga 1295581 gagaccgctg ttaatgagca tatttaaagg cgtaatcgga agggacctga gtgatattaa 1295641 agaacagctc cggcagcagg cgcttggcgg agttgacttg attaaagacg atgaaatttt 1295701 ctttgagact ggtctagcgc cttttgaaac aagaattgca gaaggaaagc aaatattgaa 1295761 agaaacgtat gaacaaaccg gacataaaac gctgtatgcg gtgaatttga ccggacgtac 1295821 ggctgatctg aaagacaaag cgagacgcgc cgccgaattg ggagcggatg cgcttttgtt 1295881 taatgtcttc gcttacggct tggacgttat gcaaggcctt gcagaagatc ctgaaatccc 1295941 agttccgatt atggcgcatc cagcagtgag cggagcgttt acgtcttctc cgttttacgg 1296001 tttttctcac gctcttttac tcggaaaatt aaaccgatat tgcggtgctg acttcagcct 1296061 ctttccgtct ccatatggtt cggttgcgct tccaagagca gatgcactgg cgattcatga 1296121 agaatgtgtg agagaggatg cttttaacca aacatttgct gttccgtcag caggcattca 1296181 tcccggcatg gttccgctat taatgcgtga tttcggcata gaccacatta ttaacgccgg 1296241 aggaggcgta catggacatc cgaacggtgc ccaaggcggg gggcgagcgt tcagagctat 1296301 tattgatgcg gtcctagagg cccagccgat tgatgaaaaa gccgaacaat gcaaggatct 1296361 taagcttgcg ctagataaat ggggaaaggc tgaagccgta tgacgactcg aaaacctttt 1296421 attatttgtg attttgacgg aacaatcacg atgaacgaca acattataaa tatcatgaaa 1296481 acatttgctc ccccagagtg gatggcatta aaagacggcg tactttccaa aacgctgtca 1296541 atcaaggaag gtgtcgggcg gatgttcggc cttctgccca gcagtttaaa agaagagatt 1296601 acaagttttg tattggaaga tgcaaaaatc agggaaggct ttcgggaatt tgtagcattt 1296661 atcaatgagc acgagattcc gttttatgtc ataagcggtg gaatggactt ttttgtatat 1296721 cctttgcttg aaggcattgt ggagaaagac cgcatttatt gcaaccatgc ttcatttgac 1296781 aatgactata tccatattga ctggcctcat tcctgcaagg gcacatgcag caatcaatgc 1296841 gggtgctgta agccgtcggt catccatgaa ctttctgaac cgaaccaata tatcatcatg 1296901 atcggtgatt cggttacaga tgtggaggca gcaaagctgt ctgacctatg ctttgcaagg 1296961 gattatttat taaacgaatg ccgggagcaa aacctcaatc atcttccgta tcaagatttt 1297021 tatgagatca gaaaggaaat tgagaatgta aaggaggtac aggaatggct gcaaaacaag 1297081 aacgctggcg agagctcgct gaagtaaaac gggaattggc agagagagat tggtttccgg 1297141 cgactagcgg caatctgtca attaaggtta cagatgagcc tttaacattt ctcgtcactg 1297201 caagcggaaa agataaacgc aaagagacgg ttgaagattt tctgctggtc gatcaaaacg 1297261 gagagcctgc tgaaagcggg cattctctga aaccgtcagc agaaacgctt ttgcatacac 1297321 atttgtacaa taaaaccaat gccggatgct gcctgcatgt ccatacggta aacaataatg 1297381 tgatttcaga gttatacgga gaccaaaaga aaatcacatt caaaggccag gaaattataa 1297441 aagcactcgg cttgtgggaa gagaacgcag aagtgaccgt tccgattata gaaaatccgg 1297501 cacatatccc gacgctagcg gcactgtttg cggaagagat ttcagaagat tcaggagctg 1297561 ttctgatccg aaatcatggt attacggctt gggggaaaac agcatttgag gcaaaaagag 1297621 tgcttgaagc gtatgaattt ttgttcagct accatttgaa attgaaaaca ctcgagcatc 1297681 agctggttaa ataaaaggag gaattgaaat ggctacaatt cgaattcatg atgaggcaaa 1297741 tacaacgatt gaaaatcaag aggaagtggc aagctttctg gacagtcaag aggttattta 1297801 tgagcaatgg gatatcacga ggcttccgga acatctctca gagaaatatg acctgacaga 1297861 agaagaaaaa cagcaaattc ttgatacctt cgaaactgaa attaaagata tctcaacccg 1297921 ccgcggctat aaagcacagg atgttatttc attgtcagac agcaatccga aacttgatga 1297981 actgcttgaa aactttaaaa gagagcatca ccatacagac gatgaggttc gttttattgt 1298041 aagcggacac ggtatttttg tcattcaagg ccaggacggc acgttttttg atgtccgttt 1298101 aaaccctgga gatttaatct ccgtgcctga gaatatccgc cattacttca cgcttcagga 1298161 ggaccgcaaa gttgtcgcgg tgagaatttt tgtcacaact gaaggctggg ttcctattta 1298221 tgaaaaagac agcgtgaatc aataagcgtg agatagcccc gttcatcgaa cggggctttt 1298281 tatatttatt gcaaacgcca cttttcatat tgtgacagtt cttttttaat cagtgtccaa 1298341 atcaaaccta aaacagctgc atcgtcaatg aatccaagac cgaggattac gtctggaatg 1298401 atatcgagcg gcatgacgat atacaggatt gcggcagtta acagcaaaag tgttttaacc 1298461 tgtgaacgag ggtagtcgcc atttcgccaa tcgcgaagca tctgaaaaaa agtagtgatg 1298521 tgctggatac atttttttcg gtttttcctc tttaaaatcg cttttccgcc tgccgctccg 1298581 agcattattg ctttcttttt cttcattggg catacctcct gcctggcggc gtgtttaaga 1298641 tattcttcac ctgggtattg ttcttctaat cctatcaata tatctattat acctgaaaaa 1298701 ttaacttatt taatgaaaat atgtttacaa ataaagtata atctgtaata atgcacaata 1298761 acccaatcaa acttgtttcc tatttcttag cggcgagggg tgaagtgaat gggcggttct 1298821 tctgaacaag aaagattgtt ggtgtctatt gatgaaaaaa gaaagttaat gatagatgcc 1298881 gctagaaagc agggatttac agggcatgac acgatcaggc acagtcagga gctggattgt 1298941 ttaataaatg aatatcatca gcttatgcaa gaaaacgaac attcccaagg gattcaaggc 1299001 cttgtaaaga aattaggctt gtggccccgc agagatgtta tgccagcata tgatgcaaat 1299061 aaatagcggc ctatcagatg catatataaa gagagagctt ttcggaagcg ctcttttttt 1299121 ctggaaaaaa ttcatatgaa agagggaact aatgaaggaa ctggcgattc tcattaccga 1299181 aatggtcaat caatttcatg atgcttttat ttccttatgc ggaatatttg gcattcattt 1299241 aactgacaaa gaaatgcatt tttgggtgat cggcattttt ggcatattct ttttcggcgt 1299301 cactcacgct gtgtttacat ggctttctaa atggagtatg acagccttgt cctttatcta 1299361 taccgttaca gtcatcattg tcatcgtatt tgcgattgag attcagcaaa aggtgacggg 1299421 gagagggaat atggagtttt tagatgccac ggaaggtata aagggttttt tagtattttt 1299481 tatgtttttt ttgcttttga aaatgctgtt gcgtttcatc aaaatccttt tttctggaag 1299541 accagcaagc aaatcgaatg gcaatgcccg atcacgaaga taaaaaaccc tcctgacatg 1299601 gtcagggggg ctatgatgcg gatacgggga gggtgatcgt cacctctgtg cctcttcgca 1299661 cttcactttc aatatgaata gagcctccgt acatcagcac gatccgttta caaacaacaa 1299721 ggccgagacc ggttcctttt tctttagaag taacaaaggg aaggaagatg tgatccagca 1299781 tttcctgaga aatcccttca ccgttatcca caactttgat tatggctttt ttatctaaag 1299841 ctcctaggga gatcgtcagt ttgcctcctt caggcattga ctcgaggcca ttttttgcta 1299901 catttaaaat cacttgttta atatgatctt ttgtacattt tacgagtaag ggctgctcgg 1299961 ttagatactg taattcgact tcaacattgt atagattgcc ctcagaataa atgatcggca 1300021 taatttctcc gataatgtcc tgaagtgagt tcagctccca tttttcagct gtcggcttgc 1300081 cgagaacgag aaactcactc actatttgat tgatgcgctt tatctcctgt tcgataatgg 1300141 agaagtaaag ctgatcttcc tcacctttat atttcttttg caacagctga ataaagccgc 1300201 ttatcccggt gagggggtta cggatttcat gggctgtgct ggcagcaagc gtcccgatca 1300261 gctctaattt ttgcgcctcg ttttctgagc gctccagctg ggtctgccgc ttcagcaaat 1300321 aatacagcac gagaataaaa aggatattca gcagaacaat aatacatgaa agcggaagca 1300381 caaggctttt cgacagttct tctattgtga ccgggttcgg atagactttc atattccagc 1300441 tgatatcatc cagatatccg ctgacaggtt tctgatcctc tgcatgagag gcttgtccgc 1300501 tcgcaaaaat cattttcccg tcttggttca caacttcaat ataaacatca gggcttagta 1300561 agttaatgag atttttcaaa taatcaattt gaatagctgc gacaagataa tctgtcacat 1300621 tacgttttga gtccaaaaca ggcacacaaa ttgtgaaaat tggctgacca gtaattctgc 1300681 tcgaataact atctgaaatg actgtctttt tagtttcctt tgcttttata aaaaaagatc 1300741 tgtcggccag gtttactttc gtttttaatt cggttgtgct tgcggtgacg tctcctttgg 1300801 cattgagaaa atagagaccg gaaaatctcg gctctgaatc aaaggtcttt tccaaaattg 1300861 attgcatttt ctttatatca accggtctgt cgatggcgat ggacaaggag gtcattctcg 1300921 ccattgtttc tccgattaaa taattgattt tgttgcggtg aaggtttagc aggacacttg 1300981 cttcttgttt atgttctgca gctattgtat ctttttcttt ttcatatacg aaaaagctga 1301041 tgacgattgc cggaatcacg accagtatga tataaagttt gactctcccg caggcgcctt 1301101 ttagtatttt caatttgcat cgctccaaca tacacctgat tagaggtatt atatcattgt 1301161 ttcttcttct ttaataagaa aaaataacca aaaaaattag aaaaagatgt tggcaagctt 1301221 acattttaaa aaagaagaga aatattggaa agatttttat tgacattttg gtctttgttt 1301281 attaatgttt ctctgtaacg gtttctaaaa ggatgattga gacatgacag aaaaatcact 1301341 gaagttattt atcgtgctgt cgcgcgcgta tcggtctatt aacgatcata tgaataagca 1301401 tattcataag catgggctga atccgactga atttgctgtg ctagagcttt tgtaccataa 1301461 aggcgatcag ccgctgcagc agataggaga taaaattctc ttggctagcg ggagcatcac 1301521 atacgttgta gataagctgg agcaaaaaga acttctcatt cggaaagcgt ctcctacaga 1301581 cagacgagtg acatttgcgc aaattactga aaaaggcatc ggtcttttga acgatatttt 1301641 ccctgatcac gctgctgaaa ttgatgaaat gatcagcgta ttaagcgaag aagaggtaga 1301701 gatgtgcacc gaaatgttaa aaagagtagg attaaacgca aaacagtttc ataataagta 1301761 aaaaaaggaa gcctgatatg tcacaaggct tccttttttg ctatttttca tttgtttccg 1301821 ctgcgcctct cggcaaaatg agaacttcaa cccgccggtt tttgcttcgg ccttccgcag 1301881 ttttattgga agccaccggt ttatactcgc cataaccctt ggcgctgaac acttttgcat 1301941 cgagcttggg gttttcaatc aggagcccca taaagtttac cgctctcatg acgcttaaat 1302001 gccagtttga ttggaattca gaatttttaa ttggcatatt atcagtatgt ccgctgataa 1302061 tgatatttct tggcgggtta atcacaagaa gatttgaaat ctcttttgca agcggcacat 1302121 cttccttacg gatggtcgct tttccagaat cgaagaagat gctgtcttta atcgtaatca 1302181 gaaggccttc actagtcatc ttcgtctcca gctgatgttc cagcttttta tctttgatga 1302241 acttttccac ctggctcttc acattttcaa gttcttcttg atcagctgct ttttcttttt 1302301 ctttcttgtt tttctctttc tcttcttttt cctttttcac ttcatcgatg ccgtctgact 1302361 cgttttcagg aggagtgaca ctggagtagt ccagtacacc ggttccgcct gtaaaaactt 1302421 cattaaatga ttttgagagc atttgaaact tagctgcgtc aatcgagctg ctcgcgtaca 1302481 gcacaataaa caatgccagg agaagagtaa ggatgtcggc gtaaggaacg agccatgatt 1302541 catcaacgtg ctcgtcctca tgcttcttct tcttttttct cgccattttg cgcctctcct 1302601 tgttctgcaa atttcaagcg gtccttcgca ggaagataca ttaaaagctt ttgttcgatg 1302661 actttcggtg cttgtccttc taaaacggat aaaacacctt caatcatgac ctcacgcagt 1302721 tttacttcct gttttgattt tcgttttaat ttatttgcga aaggatgcca taacacatac 1302781 cctgtaaaga taccgagaag tgtggcaaca aaggcagcac tgatggcgtg tccaagctca 1302841 tctgtgttat ccatatgaga gagagcggca atcagcccga ttacagcgcc gagtactcca 1302901 agtgtcggag cgtacgttcc tgcttgtgta aaaatagcgg ctcctgcttg gtgcctgtcc 1302961 tccattgctt cgacttcctc tgtcataata tctcttataa attccgcgct ttgcccgtca 1303021 acagccatgc tgagcccgtt tttcaagaaa gcatcatcta catcctcaat gcttgcttct 1303081 aaagcaagca gaccttcgcg gcgtgcaagc tgagcccatt cagagaacat aggaatgagt 1303141 tcctctattg tgagctgttt attttcctta aataacactc gaaacagcgt aggcactttt 1303201 ttaatttctt ttgttgggaa cgcaataacg actgctgaga ttgtcccggc gataataatt 1303261 aaaatggcag cggggtttgc aagggcgctg aaactgacgc ctttcagaac catcccgacg 1303321 ctcaatgcca caaaagcaag aataataccg attaacgaag ttttatccat agttttcacc 1303381 aaatcctttt ttactagctt gtctatggtt aatatcggtt ttggtgcccg gaactttagg 1303441 gacattgtga atttgttcat gaaatattca aggaagaggc atagaaggga gaaataaaca 1303501 aaaacgggct ctccaaaatt gaaaagcccg ggggtctact gaaattagca gcttgcttgc 1303561 aagctgtcct tcagatggta ttcatataat agtagaaata catattcact gtatataaac 1303621 atgttccatc cctccttaaa aaagtgtaaa ggatgaaggg aagtagcgct tcaggagaag 1303681 ggacggtaat ttctaagtca agagtatgaa agtataaaaa aaagcggctt cctaaaagga 1303741 aaccgctgat tgttattttg ctcgcacttt gattttatca tcttctaaaa tcacgtgaaa 1303801 acttgtgatc tcgccattat caagcagcag atcggtcatt tcatcctcaa cccattcttg 1303861 gatggttctt ctaagcggac gtgcaccgaa tgaagggtgg tagcccagct cagcgatttt 1303921 ttctttcgct tcatctgtca cattcaagct aatgccccgt tccgccaatg tttcttcaag 1303981 ttctccaaga agaaggctga cgattttgac aagatgttct ttttccaatg agcggaactc 1304041 aataatgctg tcaaaacggt tgaggaactc aggtttaaag aacatgctca gtgaatcaat 1304101 taatgtttgt tcttcgatga cactgtcatc tgattggaaa ccgactttcg tttgtttctc 1304161 accagcaccc gcattacttg tcatgatgat cacagtgtct ttgaagctta cagttctgcc 1304221 ttggctgtct gtcagacggc catcttccat aatttgcagg aacatatgct gaacgtctgg 1304281 gtgtgctttt tcaatctcat ccagcaacac aatgctgtaa ggattgcggc gcaccttctc 1304341 agttaattgt ccagcttcct catggccgac atatccaggc ggtgaaccga taattttaga 1304401 tacggcgtgt ttctccatgt attcgctcat atcgagtcgg ataatagcgt cttttgtgcc 1304461 gaataattca tctgccagtg ttttagaaag ctctgttttc cctacgccgg taggaccgac 1304521 gaagaggaag gagccgactg gtctgttttt ggattttaat ccggcgcggc ttcgtcttac 1304581 cgcttttgcc actttttgaa cagcggcttc ttgtccgatc acgcgttcat gaagttttgc 1304641 ttcgagttct ttcattttcg tttgttcgtc tgcctgcagt ttgccgacag ggatgcctgt 1304701 tttttgttca acaatttcct gaatgtgctc agcttccaca gtgacagcgg tatgagcgga 1304761 ggagctgttc agttttttct ccaatgcgag ttcttcatca cggagttttg ccgccagttc 1304821 gtaattttct tcttccaggg cttttgtttt ttcggcttca attgcagtta agcgttcagc 1304881 ggcatcctca tcattcagtt catcaattaa caggttggct tttgaacctg cttcatctaa 1304941 taaatcaatt gctttatccg gcaggtgtct gtcctgaatg tagcgggatg ataaagtgac 1305001 acatgctttg attgcttcat cactgaatgt tacgccatgg tacgcctcgt atttgtcttt 1305061 aatcccttgc agaatgagga tagcctgttc aattgaaggc tcctgcacca tgacaggctg 1305121 aaaacgtctt tccagcgcgg catctttttc gatttgacga tattctttca gtgttgtcgc 1305181 gccaatgact tgcagttcgc ctctggctag ggccggtttg agaatgttgc cggcgtccat 1305241 tgatccttct gcagagcctg cgccgacgag aaggtgaatt tcatcaatga acagaatgac 1305301 attttttcgt tccttcagct cagtgatcag ctgtttcatt ctctcctcaa attggcctct 1305361 gatccctgtg tttgcaacaa gagatgcaac atcaagcaag tatagctctt tgttttttag 1305421 tttgtttgga acatcacctt cagcaatttt taaagcgagc ccttcagcga tggcagtttt 1305481 ccctacaccc ggctcaccaa taagaaccgg attgtttttg tttcggcggt ttagaatttc 1305541 gatcactcgc gccacttcat catcacggcc gatgacggga tcaatgagac cggcttttgc 1305601 accgtttgta atattttgag ccagctcatc aagcaaccct tttttttcgc tttgttttgc 1305661 tgcgctctgt tctttcggct ggaatgcctg ttcaaacgga aatccgaaag attgaggacc 1305721 catactcatt gaaggtttac gggtcagttc gttatagcaa gtttcacaaa gaaccatctg 1305781 tttatgaacg gaatttattt gcatgttaag gcgaatcgtc gcctcgtttt gatgacaatg 1305841 ttgacaacgc atttgccaaa acctccttaa taatttgatc atctttgacc aatgaaagtg 1305901 aataaaaagg tctattgggt ttgaccttct ttgactatta gtatacggca aacttaacgg 1305961 cattcaaacc aatatgctca aagcagactg aatatttgac tatctttgac caattgattt 1306021 ttaaaaaagg ccggtttgtt tgaccaactt tgattaatag tatactctga ctatctttga 1306081 ctttcaagtc ttatgcacaa aaatttttga tttgttacaa agtaaaacat gttttcttcg 1306141 tcttttcaag gaacttgtct cataggttat aaaaaggcat atatggacaa aactgcggtt 1306201 cgttcggagg gaagaaatgg aacaatcaaa agggtctgca agtcagcttg cttttgtgta 1306261 tgtcggcaca gtagtcggag ctggatttgc gactgggagg gaaattgttg agttttttct 1306321 gaagttcggc tggttcggtt ttttcggcat tctcgtcagc ggcggaatgt ttacgttact 1306381 gggggccaag ctgatgatca tttcaaagcg aatcaatgcc aagtcatatc aagaaatgaa 1306441 catatttttg ttcggggcga cggctgggcg gattatcaat gtatttatgc tgtttgttct 1306501 ccttggagtt acatctgtta tgctttcagg ggcaggggcg ctttttgagg aacagctggg 1306561 gatgtccgct cagattggga tgctcattac aatcggtctg agtttaattg tgatgactag 1306621 aggagtaaaa ggcattttcg gtgtcaatgt gtttgttgtt cctcttttaa tcatcttttc 1306681 aatgattgtg gtggccgact cttttatatt cagcgaatca cgaaacgcag ctcagtgggt 1306741 ctggccgcat cgctgggatt ggctgttatc agcagtttct tacggggctt taaatttatc 1306801 gcttgcccaa gctgttttgg ttccgctggc gaatgaaatg tcatcggaga aagtgataaa 1306861 aaaaggcgct ttaatcggag gcacgatgct gacgattgtg ctgtccgcga gttttctgtc 1306921 tttgtcgact cttccggatg tatttttgta tgatataccg atggcgcaag tggtttatct 1306981 ctttgcacga tctgtccatt tgatttattt actcattatt ttcggagaag tgttcacatc 1307041 agttatcggt aatctatatg gattagaaaa acaagtgcaa agctttcttc cagtgaaaag 1307101 caaatatatc tttgcagcca ttatgatcac ggcttatatt acgagccaaa tagggtacgg 1307161 caggcttatt tcaacgattt atcccttgtt tggctatgtg agcctggcct tcataggcgc 1307221 tttgctttgc aaaaaagctc ctcggcggcg cagtttataa atatatataa tgaaacgaac 1307281 cgtcactata gagcgataat tgatctagga accggggact gactttttta ttgtcaagaa 1307341 aaacatcatt atggtaagat agcagaagtg aaaaaattga agaaaatccg tgcgatatgc 1307401 gggagaggtt ctagctacac cctctataaa aaactaagga cgagctgtat ccttggatac 1307461 ggcctttttt atgtttttct agagcacctt ccgaaaaaag gtgttttttt gcgtgaatta 1307521 gctgtagcga tgtctctcgc cggcgttttt attgcggaga aggagaggaa tcatgaaaaa 1307581 agaaaaagca attgtcgtat ttagcggcgg tcaagacagc acaacatgct tactgtgggc 1307641 cttaaaagaa ttcgaagaag tcgaaacggt gacttttcat tataatcagc gacattcgca 1307701 ggaagttgaa gtggcaaaat ccattgcgga aaagcttggt gtgaaaaatc atttgcttga 1307761 tatgtcactt ttaaatcagc ttgcaccgaa tgccctgact agaaatgata ttgagataga 1307821 agtaaaagac ggcgaactgc catccacatt cgttccaggc cgcaatttgg tattcttatc 1307881 ctttgcgtct atcctggctt accaaattgg cgcgcgccac attattacag gagtttgcga 1307941 gacagacttc agtggttatc ctgactgccg tgacgaattc gtgaaatctt gcaatgtcac 1308001 ggtaaatctg gcaatggaga agccgtttgt gatccacacg cctctcatgt ggctcaataa 1308061 ggcggaaacg tggaagcttg cagatgagct tggcgcgctg gattttgtga aaaacaacac 1308121 gctgacatgc tataacggca tcatcgcaga cggctgcggc gaatgtccgg catgtcacct 1308181 tcgttcaaaa ggttatgaag aatatatggt gatgaaagga gagcgtgcat aaattgttat 1308241 ctcaaattta tccgcaggcc cagcatcctt attcgtttga actgaataag gacatgcata 1308301 tctcagccgc tcattttatc cctcgggaaa gtgcgggagc gtgcagcagg gttcacgggc 1308361 atacgtatac cgtaaatata accgttgccg gcgacgaact tgacgattca ggctttcttg 1308421 tcaatttcag cgtactcaaa aaactggtgc acggaaacta tgatcacacg ctattaaatg 1308481 atcatgaaga tttttctcag gacgaccggt attcgctgcc gacaactgaa gtcgtggcga 1308541 aaacgattta tgacaacgta caggcttatt tagacacttt ggagaataag ccgacctgtg 1308601 tacaggtgtt tgtccgtgaa acaccgacaa gctactgtgt ctaccgtccg aaaaagggtg 1308661 gtttgaatgg ctaaaggaat tcctgtatta gaaattttcg gcccgacgat tcaaggagaa 1308721 ggcatggtga tcggacagaa aacgatgttc gtccggacag ccggctgcga ttattcctgc 1308781 agctggtgtg actccgcttt cacttgggac gggtctgcta aaaaagatat tcgctggatg 1308841 acggcggagg agatttttgc ggagcttaag gacattgggg gagatgcgtt ttctcatgtg 1308901 acgatctcag gcggcaaccc ggctctgtta aaacagctgg atgcttttat tgaactgctg 1308961 aaggaaaata acatccgtgc agcgcttgaa actcaaggga ccgtttatca ggattggttt 1309021 acgctgattg atgacctgac aatttctcca aaaccgccaa gctcaaaaat ggtaacgaac 1309081 tttcaaaagc ttgaccacat tttaacttca cttcaagaga atgatagaca gcatgctgtc 1309141 agcttgaagg ttgtcatctt taatgatgaa gatctggaat ttgccaaaac tgtgcacaag 1309201 cggtatccgg gaatcccgtt ttatttacaa gtcggaaatg atgacgtgca tacgacagat 1309261 gatcagtcac tgattgcaca tttgcttgga aaatatgaag cgcttgttga taaggtagct 1309321 gtcgatgcgg agctgaatct cgtcagagtg ctcccgcagc tgcacaccct gttatggggc 1309381 aacaaacgcg gagtataata gaaaggaaga tgaacatgac gacaagaaaa gaatcagaat 1309441 tagaaggtgt aacattgcta ggcaatcaag gtacaaatta tttgttcgaa tatgcaccgg 1309501 acgtgctgga atccttccct aataaacatg taaaccgtga ttactttgta aaattcaatt 1309561 gcccggaatt cacatcttta tgtcctaaaa caggccagcc tgactttgcg acaatctaca 1309621 tcagctacat tcctgatgaa aaaatggttg aaagcaaatc attaaagctg tatctattca 1309681 gcttcagaaa ccatggtgac ttccacgagg actgcatgaa tatcatcatg aacgacttga 1309741 ttgaattaat ggacccgcgc tacattgaag tatggggcaa attcacgcca agaggcggaa 1309801 tttccattga tccgtacaca aactacggaa agcctggcac gaagtatgag aaaatggccg 1309861 aataccgtat gatgaaccat gatttgtatc cggagacaat tgataatcgt taattattcc 1309921 gttgtgtgat acggagtgta aaaggaagtg gagtcacagt aaaatccgaa cattcagcgt 1309981 taattttcag cggaaatgtg acctggtcac agcgaagtgt gacccgcact aagctcaata 1310041 aaagtgggaa aagtcacacc tgaaaatggc tctactcatg ggaattgtat taaaaagtgt 1310101 gacctgaggt gcaacctgaa ctgtgacttt tatgcagtga aaaattgata gtacagaagc 1310161 agattaaggc gtacaatttg tacgtctttt cttttttatc cgaaagaaaa aatgcctatc 1310221 tagagatcat aggcattaaa tattattatc aatatcttca tttatttttt ggctaagttt 1310281 ctgaaccttc tctttaacat ttgaaacagc tcttttttga atttcatcaa ttctcctgaa 1310341 tatagtcgat gacacttctt attagaactt cactttcaaa attgaatatc tcatttattt 1310401 ctgactgttc ttcatctgtt aggtgatggt attgaagttg tttagcattt acttcagcag 1310461 ctacatcaat cctaacttag ttgttctggt tgtacaattt catattcacc ttctgcatac 1310521 tcttgctccg cataatagcc tccccattga cagagctcct gcaagatagg tttaagagat 1310581 tctccaagtt cagtggatga atattcaacc ttcggcggta cttgattata catctttctg 1310641 ctcacaagtc cactggcttc aagctctcta agtgtttgaa tcagcatttt ctgagttata 1310701 tttgggataa tgcgctttaa ttcactcgtt ctctttggtc cattcattaa aaagtataat 1310761 acaaggcctt tccattttcc gccaataact tcctttgtca cttcaaaccc acagctaaat 1310821 tttttcatgt ctaaagctct ccattccaca tttattactt tttagttact atatcacaaa 1310881 aaagtgggta cttccgataa tgtgcttact gaaggatact atatcttgta agttgttctt 1310941 caagtactta aaggtactag acataaaata aaattaattc taaaggagtg ttaagtatgg 1311001 gtaaatttga aggtaaaata gcgcttgtaa cgggtggaac aagtgggatt ggtcttgcta 1311061 cagcacaaaa atttgtaaac gaaggtgcat atgtttatat tacgggacgt agacaaaacg 1311121 aacttgataa agctgttaac caaattggca agaacgtaac cggtgttcaa ggtgatattt 1311181 ctaagcttga agacttagac aaactatatg acattataaa gcaggaaaaa ggtaagttgg 1311241 acattctttt tgctaatgca ggcatcggca acttccttcc attaggtgaa attactgaag 1311301 agcaggttga tagaacgttc gacattaacg ttaaaggaac catctttact gttcaaaaag 1311361 cgttatcact attcccggac aaagtaggtt ctattattgt aacgggctct actgctggat 1311421 caattggcaa cccagcgttt agtgtatatg gagcatctaa agcagcatta agagcactag 1311481 ttcgcaactg gattcttgac ctaaaaggta ctgaaatccg tgtaaatgtg gttagtccag 1311541 gaggtattct tacacctgcc tacgatgagc tttttggtga tgcacttgaa gaggtactgg 1311601 aaaatagcag aaatactgtt ccagctggaa aagttgggac acctgaagaa gtagcaaacg 1311661 ctgtatcttt ccttgcttca gacgaaagca gttacttgac gggtgttgaa ttgttcgtag 1311721 atggcgggct agcacaggta taatttcact gcgcagagat tacaaatagt ccccaaaaaa 1311781 ggttaatggg gatttacttg aagaagtcgt ataaaaaagt cgttttcctt aaaggacagg 1311841 gaattcgact tttttatatt tgaatttgat taacgttgta aattcgcatt ttcctggggc 1311901 tactactaaa tgacctgtaa aaaagattac actgtgaata aatgtactta aagtaacggg 1311961 ggctcttgac ttttaataaa aaataatatc cctgtccttg tattctaata cttttaaaaa 1312021 tatttaaagg aatccttatg tcctgaataa ccacatagga aaatatgttg taggttgctt 1312081 tctttttttg tggggcatcc cacacaagct atctcgtgat ctcacacctg aacgtttttt 1312141 atagactagt accgcgacaa gttatattac atatacatac caataaagta gacattaaaa 1312201 agtgaaagag aggatggaaa tgtgtgaaaa ttcttttcct tgagagtcat cccatgtggc 1312261 tctatggttt accgaatggg tttagggaag caggacatac cgtaatgatt tccggtcctg 1312321 taagtcggga aaatataact gaaatgatag acgaatttaa accagattta atagtatcta 1312381 tgggatggac accagagcat tcaagggaaa agcaggcctg gattcgcaac gctactaaaa 1312441 aggtgaatat ccctctcgtt tattgggcaa ctgaagaccc gctgcacact caaaacttta 1312501 ctatcccgtt aattaaaaag atgaaaccgg attttgtttt cacggtcacg ccttctctgt 1312561 gtaaaactta tgaaagcatg gggattaaag cagctcactt agactttgca tttcacgaaa 1312621 gtatacatca ccagattaaa ccattagcga aatacagttg tgatatagca gtggtggcta 1312681 atgcttaccc taattttctt gaagaacatc cggaagtgtt ccgttcgtcc tctttaaaaa 1312741 cgcttattcg tcctcttata cggaagggta ttcgcattga tttttggggg agaaactggg 1312801 aaaaaatgag taaatatata ggaagagaaa ttccccgcaa ttggatccat ggataccttg 1312861 attatactga agcatataaa gtttacagtt cagcaaaaat cattatcggt ttgcaaaact 1312921 gtgaaagcca acttacacaa cgcacctatg agattcttgg ttccgggggg tttttattga 1312981 catcggatac accagcagtt cgaggtaaat tcaaacctgg ccgcgatctc atcgtttctt 1313041 cctccccaaa agaaacattg gaaaaggtta aatactattt aaatcatgat agcgagagaa 1313101 aaaagattca gataaacggt aaaaaggctg taaagaatga ttcctatcgg catagagccg 1313161 agagaatgct tgaggtgcta aaaagcagag gaatcataag aaacttaggg gaaaccattc 1313221 attatgtaga tgttctcaaa gaaaaatacg tgatccatca tgttactccc ggtgaaacat 1313281 tatcaataat tgccagtaag tataatgttt ccctgcagca actcatggag cttaatcatt 1313341 tcaaatcaga tcaaatatat gctggacaaa tcattaagat tagagagaaa ctgtttagaa 1313401 atattaataa caaattattc taaaggagag taatatgaat gaaggggaaa atacctaaaa 1313461 taagaaatca agcgaataaa gtaaaaagaa cgcctcgtta tatggaattt cccgtgacat 1313521 acgaagtata tcatgtggaa tccggcgata cattatggac gattgccaaa tcctttgaaa 1313581 ttccggtaca acaacttatg aatcttaata agctttcttc agatagaatt tatcctggac 1313641 aaattataaa gataagagaa agataatctt tgaggtttcg gaagcgaatc aaattgaaat 1313701 gacaatcctc atttttttat ttgtggggaa cttgatattt ttggggatga aggggttatg 1313761 agatgtttca aatgagctat tactattctg gattaggatg ggactttatt caacacgttg 1313821 atcaaacgaa cggagtatta aatgttgtgt ctcctgattt tttctatatc agaaaagatg 1313881 gatcattact tctccgttca gctaatcccg atgtgattaa agctcttcat agaagaaaat 1313941 taaaagtagt tccttttcta agcaatcatt gggatcagga tttgggacga tttgcattaa 1314001 tgaaccgagt tcttttagct aaacaaattt ctcatgcaat agaagaactg gatttggatg 1314061 gagttaatat cgatatagaa aaccttacag aaaaagatcg gaatctattt acagatttta 1314121 ttagattagt aaggaaaagt attcctagac ataaagaagt atcagttgca gtggcggcaa 1314181 atccttttgg ctggacgaag ggctggcacg gatcatatga ttacgagtat ttagctaaat 1314241 atgcagatta tcttatggtt atggcctatg atgaaagccg ccttgctggg cctactgcaa 1314301 gtgtaggatg ggtggaaaag tccattcaat atgttctgac ccaaaaaatc tctcctcaaa 1314361 aactagtttt aggattgcca ttctatggcc gctgctggat ggaaggccaa tctgcctctc 1314421 aagccattcc cctttacctt gttgttagta aaaaggcata gcgggacaat tatttttgac 1314481 accaagagtc aatctccaaa agctattttt actgtcaatc acgataaaaa ggggccgttg 1314541 ccttcgggaa catatacatt atggtttgaa aatgaacagt cactcagagc aaaaataaaa 1314601 ctcgctcaaa aatataatct gaaaggtctt ggcagctgga gtcttggaca agaagatgcg 1314661 tcagtctgga atacagtgtt taaaaatata taatgattta tagttcagaa caaaattcga 1314721 agataattgc aatgaatctc taaatggaca tactgaaagg agtttattac gagtgcgggt 1314781 aaaacagtga gggcattcca taggcccttc tcccaaaatg ttctacacga ggcattacat 1314841 tgggcttgaa atacacattc aaacttatgt tatagtacgc attttacgga tgtgttgaat 1314901 ttattctgct tccatgattt aatcatacac atgctacttg atagcagggt tatcgcattt 1314961 cattcagaat tgttcaggat cgatatggaa gcgcacgact aactagaact ttaaaagcat 1315021 acactcatat acttcctgaa tggatgctgg tttatctaaa aaacatgatg agaattgatt 1315081 gtacgcatgg tgaagcatga cttgttgata atcgaccata tggtttctcc ttagaaatga 1315141 gggggttttt acataaaaaa gacgagcgaa tccgggggga attccactcg ccgctttcta 1315201 atgaaaagac gggatgctgg atggcagctc gtctgtttta ttataattta acgaacgtat 1315261 gtttgtaaag gtgtcttttc gaatgaattg gttcatataa ccgttaagaa cagattcatt 1315321 gtaaacattc gctaaggtat gctaagatgc atggactata aaggagtgat atgaagtgaa 1315381 gacattgcgg ttaaacaatg taacgttaga aatggctgca tatcaagagg agagcgagcc 1315441 gaagcgaaaa attgcattta ccttaaacgt tacgagtgag acttaccatg atatcgctgt 1315501 cctgttgtat gaaaaaacgt ttaatgtcga ggttccggaa cgcgatcttg ccttccgggg 1315561 ggaaatgaca aattattcaa catcattgac caacctgtac gaaccagggg ccgtcagcga 1315621 gttctatata gaaataacgg aaatagacaa aaacgccgat tcatgatcgg tgttttttat 1315681 gtaaaaaagc tgccggccgg cagcttttga gaaagcgaat ttcatatgta aggtgttaaa 1315741 ttgtccgtct tgcagttttt tgaataaatg tggaaataag gaggttttaa taggagtctc 1315801 tgatgatctt ataattttta tgattaacaa ctgtcaatga atctaactca agatcccgat 1315861 agttatccat gatcgtcaca tcaacgataa cagaattctc atttactttt tcaacaacac 1315921 cggttaatcc gtttttaaat tcaatgacat tcccaacctt agcgattttc acaagcttcc 1315981 tctcctttaa acataataat gccttttgaa agtattttgc agtattttca ttgagaagta 1316041 aagcgataag gagttttatc tcccttatga attgttctgt cgctataaag atgatatatt 1316101 gattttcgtc aatagaaaga aaagggggga atttttgttg cgtcccgaag aaataacaga 1316161 aatgattgaa cagctgcgca ccggcgccat aaacgaactg agagtccaga aagagcattt 1316221 tcttgatttc agggccgtgt tatctaaaca agatgatttt aaacatttcc gaggaattgc 1316281 ccagcaaggc ggagatgtta tctttcaata cttagaacag ccaagaagct gaaggtttct 1316341 catacgtgag aagccttttt atcatatatg acagaacaca agccttttat tacagctgtc 1316401 tgtaacaggt gtaaataaaa tgtaaagtac caaagatgga taaacatgtt ttaatttaac 1316461 aatatttata gaatttcaga ctgttttttt gccattaagc agtgagtcat cctctttatt 1316521 ccatcctgat acctccttgg gagagttgga aaatcttttt ccgtgaaaat gaatggatct 1316581 cttgttaagg ttatgaagtg ttttttggag cactttaagg aggaaactgt atgacaacga 1316641 aattcactgc tctggctgtt tttcttcttt gtttcatgcc tgcagccaaa attgagcata 1316701 cacaagcttc actactgagc gcaaagaaga caaaacatga agaagcgaaa tggcttacac 1316761 atatagatcg aaatacgaat gaatctttcc cttcactgtc tgctgataaa gacaagaaaa 1316821 taaaaccgat taagctatca gcacacactg aaaagaaaga gaaagataaa ccggacaaaa 1316881 caaatgatga gaaagaaaca tatacacagt ctgaaaaaga gttgctgtcc cgtctcgttc 1316941 acgcagaggc caaaggagaa tcatataaag gcaaggtcgc tgtagcaagc gttgtactga 1317001 acaggacgga gaaaaaaggt tttcctgata cgataagagg agttatttat cagaaaaacg 1317061 cctttgaacc ggtcgcaaac gggagcatta accaaaagcc tgataaagaa tcgattgaag 1317121 ctgccgaaga agcgctgtcc tcaaaaaata gagaaacaga tgccatattc ttttataatc 1317181 cgaaaacagc gtcagataat tggattcgtt caagaaaaat cgtagaaaaa atcggcagac 1317241 acgtttttgc cgtctaagca tagaagagac aatttgtctc agctgtgctt tttttcatat 1317301 aaagagtaaa aataaaataa tttttgaact tgtctcatat gatgttggta gtacaagaga 1317361 caaggagaga catcatgaat cgatttgtga aagggatcat tcttttatcc attgccgcct 1317421 ttttcgctga atgccttgaa tttgtcgtca atatgatttt ggcgcgggag cttggcgagc 1317481 atgggatggg gctttacatg agtattttgc ccacgatctt tttaattatt gtcatcgcga 1317541 gcctggaact gccgatatcc atttctaaat tcattgccga gtcaaatcct aagcttcatg 1317601 aaagcatgct gaggcacgct ttcagaatga cagccatttt tactgctttt tctactgccg 1317661 ccgctagtat tgcgcttccg tttattccgg tatttgatac ataccacccg tttattaaag 1317721 ggattgtcat cggcttaatt cctgttgtcg cctttacttc aatcgccagg ggctacttta 1317781 tgggtgtgca gaaaatgggg aagatcgcaa ttgccaatgt gctgaaaaaa atcatccagc 1317841 tcttgtgctt attcctcttt tttcaatggt actcatttga attggacatg gctgtgctga 1317901 tttccttgtt tgttctagtc gtgagtgatg tggtcgtgct tgtttattta tattcacaat 1317961 ttatcatggc aaggcgggcg ttatccggcc agcagcacat tcatttgcgc ggaaaggatg 1318021 taaggaaaag actgcttgct gtttcaattc ctacaacagg actgcgtatt tttcatgcgg 1318081 ttgtcaatgc aattgaaccc tttttagtaa aaggagctct tttggctgcg ggcgttgccg 1318141 ggacagcggc gatcgatcaa tacggaatgc tggcaggagt ggctgtgacg atagggtcgt 1318201 tccctgcttt tattgcccat tcgttaatgg tcgtcatgat accgagtatt tcggaagctt 1318261 atgcactttc tcagtatgac atcgtgttaa aaaggctgaa gcagtcgatt ttcattacat 1318321 taggttacgg tatacctgcc gtctgggtca tgttccagtt tgcgggacct ctcacgcatt 1318381 tgttttttca ctctcctgaa gcgcagtatt acttgcagct gttgtggcct tactttctct 1318441 ttcatctgtt tgtcatgccg ctgcaggcgt gcttaatcgg gatgggtttt gtgaaagagg 1318501 ctttttatca caatgtatgg agccatatcg ttgcgctaag tatgatgtat gtactgggat 1318561 caatggagaa tctgcaaatg ctcgggatta tccttggaat gaacactggc atgattcttt 1318621 tgacgagcct gcactatgcc acgatctgca aagcattgaa ggtatctgta tttcttacgg 1318681 gagggaccag aacgccgcga attgaaggat gataaaggaa cagcaggggc aagctaattg 1318741 aaaagcatga aaggaagatt ccatgttgac gaagcgcttg cttactatat acattatgtt 1318801 attagggttg attgcatggt ttccaggtgc ggcacaagct gaggaaaaac agcctgctgt 1318861 tcccgctgtt tttcttatga aaacgataga aggggaggac atctcgattc cgaataaagg 1318921 gcaaaaaaca attctccatt tttggacgtc atggtgcccg ccctgcaaaa aggagcttcc 1318981 acagtttcaa tcgttttatg atgcccatcc atccgacagt gtaaagctgg taacggtgaa 1319041 tttagtgaat tcggaacaaa atcagcaagt cgttgaagac tttattaaag caaacaagct 1319101 gacgtttccg attgtccttg actcaaaagg ggaattgatg aaggagtatc atatcatcac 1319161 gatcccaaca tcatttttgc tgaatgaaaa gggagaaatt gaaaaaacaa aaattggccc 1319221 gatgacagcg gaacaactga aggaatggac ggaagaatag ctgagagcat agactctcag 1319281 cttttttcat atagagaaga agtgaataaa cattaatgat aattattatc aaaaagaaat 1319341 taaaataatt ataattgaaa ttctcttcgt gcgtgctata ataaaggaag acatcaagaa 1319401 ataactgacg ataaagctgc cttttgggca gcgattttgt ttttataaga gaaatgaaga 1319461 tgatttacgt tctcaattag agaggagaat tcgatatgaa tgaacaagtt atcgttcaac 1319521 gcgacccgca tgagccattg aaaacagaca agagggaaaa aaactgggca cagcacgcgg 1319581 agcttattgc agcacttgta tcaggcgctc ttattttggc aggctggctc ttatccggat 1319641 atcaggtatt atccataata cttttcttgc tggcttttgt gatcggcgga tttgctaaag 1319701 cgaaggaagg aatcgaagaa acactcgaat ccaaaacgct gaatgtagaa cttttaatga 1319761 ttttcgctgc cattggttcc gccttgatcg gatactgggc agagggtgct attttaatat 1319821 ttattttttc cttaagcgga gctttagaaa catacacgat gaataaaagc agcagagatt 1319881 taacgtcttt aatgcagctt gagcctgaag aagcgacatt gatggtcaat ggtgaaacca 1319941 aaagagttcc ggtttcagac ttgcaggccg gtgatatgat tgtgatcaaa cctggagaac 1320001 gcgtagcggc agacggtatc attgaatcgg gctcgacaag tcttgacgag tcggctttaa 1320061 caggtgaatc aatgcctgta gaaaaaaaca caggcgacac tgtattcaca ggaacggtga 1320121 atcgcaatgg ctccttgaca gtccgtgtca cgaaagcaaa tgaagattcg ttattcagaa 1320181 aaattatcaa actggttgaa tcagcgcaaa atagtgtttc acccgcgcag gctttcatcg 1320241 aacgatttga aaatgcttat gtgaaaggtg tgctaattgc ggtggcgctc cttttattcg 1320301 tcccgcactt tgcgctgggc tggagctgga gtgaaacctt ctaccgcgca atggtgttta 1320361 tggttgtcgc gtcaccttgt gcgcttgtcg cctctattat gccggcggcg ctgtccctga 1320421 tttcaaatgg cgcccgcaac ggtatgcttg tgaaaggaag cgtctttctt gaacagctgg 1320481 gctcagtgca aatgatcgcc tttgataaaa ccggaactgt aacaaaaggc cagcctgccg 1320541 tagagacgat cagaatagca gaaggattca gtgaagcgga agttcttgag gctgtctatg 1320601 ccatcgaaac gcaatcaagc catccgctcg cccaagccat aacggcgtac gctgaaagcc 1320661 gcggcgtgaa tcagtccggc tacatatcta tagaagaaac ctcagggttt ggcgttatgg 1320721 cagaagtgtc gggtgcgaaa tggaaggtcg gtaaagcagg ttttatcggc gaggaaatgg 1320781 cagcacaatt tatgaaacaa acagcatcag atgtcattca aagcggtcat acaattgtat 1320841 ttgtgaaaaa ggatgatcaa atagcaggct gtatcgcact gaaggaccaa atcaggcctg 1320901 aagcaaaaga ggtcatggaa gaactgaacc gacttgggat taaaacggcc atgctgacag 1320961 gagatcacga agacacggct caagcgattg ccaaggaagc cggcatgaca actgtcgtgg 1321021 cagaatgcct gcctgaccaa aaagtgaatg aaatcaaacg gttaaaagaa gaattcggaa 1321081 cgattgcaat ggtgggtgac ggaatcaatg atgcgccggc actcaaagca gcggatgtcg 1321141 gcattgcgat gggcggcgga acagatgtag cacttgagac cgctgatatg gtcctcatga 1321201 aaaacgattt gaaaaagctc gtaaacatgt gccgcttgtc tcggaaaatg aacaggatca 1321261 tcaaacaaaa tatcgtgttt tctctagctg taatctgcct gctgatttgt gcaaactttt 1321321 tgcaggcgat ggaattgcca tttggcgtga ttggtcatga gggcagcacg attttagtca 1321381 tactaaacgg tttaagactc ctaaaataaa accagcagcc taatcaggct gctggctttt 1321441 tatgtatcaa gctttccctt catttttgtc tttatcagat cttttcataa ctaggatgag 1321501 agcgagggtg cagcaaagga aacccgctgc acagcctatg atagagctgt aataataaaa 1321561 gcccaccatc ttcatcccga taaaaggagc ggaaattccc aaaaccgtta agagcataac 1321621 tgcttttcgt ctgaaaaaat tcatcagcaa acggaacaac ccccctgcga ttgaacgtta 1321681 ctgtcagtat acaggaagag gagcaggaaa taaaatgcat tagaaaatga aggcgtcgtg 1321741 aaaggcaaac accggtaaaa cctgttacaa tggaagacag aacaatgcat tgcaaatggc 1321801 agggaggaac aagaagtgaa tagaatacaa cgcgtctctt catggctgaa ggaagcgggg 1321861 catactgccg catttattca tacgaaagaa aatgtttttt acttaaccgg tttttacaca 1321921 gagccgcatg aaagattaat ggggttattt atttttcaag aagaggagcc tttctttgtt 1321981 tgtccaggaa tggaagcagg acaggcccgc aacgcaggct ggaatcatga aatcattggc 1322041 tatgcggatc acgaaaatcc gtgggagctg atagagaagg ctttgaaaaa gcgaaatatc 1322101 agcatacata tgcttgcggt agaaaaggat tcaatctcgc tgtcacgtgc agaacagctg 1322161 aagcatgcga cgggcggggc tcaatttgtt tcagcagaag aaacactcaa tcaatttcgc 1322221 ctgattaaag atgacaatga gattcgtttg ctgaaagagg cggcaaagct tgcagattac 1322281 ggtgttgaag tcggcacagc cgctttgcgt gaaggcatca gtgaagtgga agtgctcgct 1322341 caaattgagt atgagctgaa gaaaaaagga attcagggca tgtctttctc tacaatggtt 1322401 ttattcggag aaaaatctgg ccagcctcat ggaaatcctg gtacagccac gttgaagaaa 1322461 ggtgattttg ttttatttga tctcggtgtt attcttgatg gctattgctc tgatattaca 1322521 agaacgtttg catacaaaac catcaatccg aagcaggagg ccatttacga gactgtgctt 1322581 caagcggaaa aagccgcgat tgaggcaagc aaacccggtg tgagaatcgg agatctggat 1322641 ttaactgccc gcggaatcat tgaaaaagcg ggatatggtg attattttcc tcaccggctt 1322701 gggcatggac tcggaatttc agtccatgag tatccatcaa tgagccaggc caacgataca 1322761 ctgctgcagg aaggcatggt ctacacgatc gaaccgggga tttatgtgcc agagatcggc 1322821 ggcgtacgca ttgaggatga cgttcacgta acaaaggacg gagcagttgc tctgacccaa 1322881 tatccaaagg atttgatcat actgtaatag aaataaaaaa ggactttgtt ctcgacatcg 1322941 tcctttttta tctgcattaa ataaaaaaat catcaaatgt tcgaaagggt ttaatttcat 1323001 gtttttggtt gagaggtttt acagcaagac agctgccacc gagaacagtg agacataacc 1323061 caattaaaat gaagaaaccc atgtgatctt ctcctttcag ctaaaaacac aaaaagatat 1323121 ctggtacgtc catatcatat tgtatgaaac gcattccaga tcaaggggat ttagaaagaa 1323181 gggaatctat ggctaatatt aaagacattg cagagaaagc cggtgtctct gttacaacgg 1323241 tttcccgagt cataaacaat catccatacg tcagtgaaga caaacgaaaa agagtgtttg 1323301 aggcaatgga atcattggag tacacgagaa atattcacgc tgtacatttg tcgaaaggat 1323361 tttcaaacat gattggtgtt gtcttgccga cggttaatct gccatatttt gcagagctga 1323421 ttgcaggaat agccgacgca gccgcggaat ccggggttca cctctcttta ttccaaacaa 1323481 actatgaagt acaaaaagaa atctttgcgc tgtcccaatt aaagcagcgc caggttgacg 1323541 gcctgatttt ttgctcaaag gcgcttgctg atgagaaact catggaatgg gagggcccga 1323601 ttttgctttg ccagaattca gataatgccc gcttcccaac catcagcatt cctcaccaag 1323661 aagcatttcg gaacggcttg gactatttaa ttgccaaagg gcacaaaaaa atagccatct 1323721 gtttggcaag aaaaaaaggc atgaacagcc attttcgaat caaagcctac aaagaggcat 1323781 tggaagagat cggcgaggca tttcgtgaag actgggtaat tgagaaagcg attacaatca 1323841 atgatgggaa ggcgcttttt cataaatgga atacgtggaa ggaaaagccg acggctattt 1323901 ttgttgccaa tgaccaagtc tcagcagggc tttttcttga agcaaagaac cagcgggtgt 1323961 cagtaccgga tgagcttgca atcttaagcg ttgataacca cgaaatcagc caagcgcttg 1324021 gaatcacaac gatcgatatt cagacaaggg aaatgggaaa gcaggcattt gccatattgg 1324081 aaaaaagaat tcaaggacag ccgattgaaa ggaaagttct ggattaccgt ctcatcgaaa 1324141 gatcgactgt ttagtgaatg cattgaaaaa aggtttgacg tgcattctgt tcgttatgta 1324201 cgatatgagg tattgaatga caaaggagct gaggatcgtg aatgggtcct tcacagtgaa 1324261 aaaggtactg aataataacg tattaattgc ttctcatcat aaatacagcg aagtcgtttt 1324321 aatcggaaaa ggtattggtt tcggaaaaaa acaagatgat gtcattgaag ataaaggcta 1324381 cgataaaatg ttcattttaa aagacgagaa ggaacaaaag cagtttaaaa agctccttga 1324441 ctatgttgat gaaaagctcg ttgatatttc aaacgatgtc atctatcaca taagcaatag 1324501 gacgaatcac tcattaaatg aacatattca cattgcgttg acagaccata tcgcatttgc 1324561 gatcaaaagg cagcagcagg gatttgatat gaaaaatcca tttctaatgg agactcagtc 1324621 actatatcct gaggagtacc aaattgccaa agaagtcata gatatgatca atgaaaaagc 1324681 gggactctgc cttccggaag gggagattgg ttttatcgct ctgcatatcc attcagcgtt 1324741 gacaaaccgt ccgctgtccg aggtcaatca gcactctcag ctcatggcgc agcttgtcga 1324801 ggtgattgaa gactcatttc aaatgaaagt aaataaggaa agtgtcaact atttgcggct 1324861 gatcaggcat atcagattta caatagaaag aattaaaaaa gaagaaccga ctaaagaacc 1324921 agaaaaatta atgttgttat tgaaaaatga atatccgcta tgctacaata cagcttggaa 1324981 attgattaaa atcttgcagc aaacattgaa gaaaccagtt catgaggcgg aagcggttta 1325041 tctgacgctt catctgtacc gattaaccaa taaaatttca taaattcagt ttatccttat 1325101 aacgtgttac tgattcgatc aggcatgagt gattgaggga aaaaaacggg aagttcattc 1325161 tcgttctttt gcgcacccaa ttttgctcat gcctttttgt tgtgtaaaag ggcaaatgta 1325221 aacggttaaa ctggaagact tacgcctgtg aattcgttgt catgattttt agctgtaagg 1325281 tcagactagt aaaaagagga ggtcaattct tatgtttaaa gcattattcg gcgttcttca 1325341 aaaaattggg cgtgcgctta tgcttccagt tgcgatcctt ccggctgcgg gtattttgct 1325401 tgcgatcggg aatgcgatgc aaaataagga catgattcag gtcctgcatt tcttgagcaa 1325461 tgacaatgtt cagcttgtag caggtgtgat ggaaagtgct gggcagattg ttttcgataa 1325521 ccttccgctt cttttcgcag taggtgtagc catcgggctt gccaatggtg atggagttgc 1325581 agggattgca gcaattatcg gttatcttgt aatgaatgta tccatgagtg cggttcttct 1325641 tgcaaacgga accattcctt cggattcagt tgaaagagcc aagttcttta cggaaaacca 1325701 tcctgcatat gtaaacatgc ttggtatacc taccttggcg acaggggtgt tcggcggtat 1325761 tatcgtcggt gtgttagctg cattattgtt taacagattt tacacaattg aactgccgca 1325821 ataccttggt ttctttgcgg gtaaacgttt cgttccaatt gttacgtcaa tttctgcact 1325881 gattctgggt cttattatgt tagtgatctg gcctccaatc cagcatggat tgaatgcctt 1325941 ttcaacagga ttagtggaag cgaatccaac ccttgctgca tttatcttcg gggtgattga 1326001 acgttcgctt atcccattcg gattgcacca tattttctat tcaccgttct ggtatgaatt 1326061 cttcagctat aagagtgcag caggagaaat catccgcggg gatcagcgta tctttatggc 1326121 gcagattaaa gacggcgtac agttaacggc aggtacgttc atgacaggta aatatccatt 1326181 tatgatgttc ggtctgcctg ctgcggcgct tgccatttat catgaagcaa aaccgcaaaa 1326241 caaaaaactc gttgcaggta ttatgggttc agcggccttg acatctttct taacggggat 1326301 cacagagcca ttggaatttt ctttcttatt cgttgctcca gtcctgtttg cgattcactg 1326361 tttgtttgcg ggactttcat tcatggtcat gcagctgttg aatgttaaga ttggtatgac 1326421 attctccggc ggtttaattg actacttcct attcggtatt ttaccaaacc ggacggcatg 1326481 gtggcttgtc atccctgtcg gcttagggtt agcggtcatt tactactttg gattccgatt 1326541 tgccatccgc aaatttaatc tgaaaacacc tggacgcgag gatgctgcgg aagaaacagc 1326601 agcacctggg aaaacaggtg aagcaggaga tcttccttat gagattctgc aggcaatggg 1326661 tgaccaggaa aacatcaaac accttgatgc ttgtatcact cgtctgcgtg tgactgtaaa 1326721 cgatcagaaa aaggttgata aagaccgtct gaaacagctt ggcgcttccg gagtgctgga 1326781 agtcggcaac aacattcagg ctattttcgg accgcgttct gacgggttaa aaacacaaat 1326841 gcaagacatt attgcgggac gcaagcctag acctgagccg aaaacatctg ctcaagagga 1326901 agtaggccag caggttgagg aagtgattgc agaaccgctg caaaatgaaa tcggcgagga 1326961 agttttcgtt tctccgatta ccggggaaat tcacccaatt acggatgttc ctgaccaagt 1327021 cttctcaggg aaaatgatgg gtgacggttt tgcgattctc ccttctgaag gaattgtcgt 1327081 atcaccggtt cgcggaaaaa ttctcaatgt gttcccgaca aaacatgcga tcggcctgca 1327141 atccgacggc ggaagagaaa ttttaatcca ctttggtatt gataccgtca gcctgaaggg 1327201 cgaaggattt acgtctttcg tatcagaagg agaccgcgtt gagcctggac aaaaacttct 1327261 tgaagttgat ctggatgcag tcaaaccgaa tgtaccatct ctcatgacac cgattgtatt 1327321 tacaaacctt gctgaaggag aaacagtcag cattaaagca agcggttcag tcaacagaga 1327381 acaagaagat attgtgaaga ttgaaaaata agggtgttag tacgccgtgc ttgtcagatg 1327441 acaagtacgg ttgtatgata taatattgtg aagtaataaa gctttaagtt aaaaggagaa 1327501 tgataaaaat ggcacaaaaa acatttaaag taactgcaga ttctggaatc catgctcgtc 1327561 ctgcgacagt tcttgtacaa actgctagca aatacgacgc tgacgttaat ttagaatata 1327621 acggcaaaac agttaacctt aaatctatta tgggtgttat gtctttaggt atcgctaaag 1327681 gcgctgagat cacaatctct gcttccggag ctgacgaaaa cgatgctctt aacgctttag 1327741 aagaaacaat gaaaagcgaa ggactcggcg agtaatgcaa gaattaaaag ggattggtgc 1327801 ttcagccggc atcgcgattg caaaagcgta ccggcttgaa gagccagatt taacggttga 1327861 aaagaaaaac atctctgatt ctgaagcgga agtaagccgt tttgatgaag cgattgcacg 1327921 ttcaaaagaa gagctcgaaa aaatcaaaga gcacgctttg aaagaactgg gtcaggataa 1327981 agctgatatt ttttctgctc accttttagt tctcagtgac cctgagcttc tgaaccctgt 1328041 gaaagaaaaa atcagcactg attcagtgaa cgctgaattc gctttaaaag aaacgtcttc 1328101 tatgttcgtt actatgtttg aatctatgga caacgaatat atgaaagagc gtgcggcaga 1328161 tatccgcgat gtaacaaaac gcgtaaccgg ccacctgctt ggcgtcgaaa ttccaaaccc 1328221 aagcatgatc tcagaagagg ttattattgt agctgaagac ttaacaccgt ctgacacagc 1328281 tcaattaaac cgtgagttcg taaaaggatt cactactgat atcggcggac gcacatctca 1328341 ctctgccatc atggcacgtt ctcttgagat tccagcagtt gttggaacga aagctgctac 1328401 aggcacgatc caaaacggcg tgactgttat cgttgacggt atcaatggcg atgtcattat 1328461 tgacccatct gcggaaactg taaaagagta tgaagaaaaa cataatgctt atttggctca 1328521 aaaagctgag tgggcgaagc ttgtcaatga accgactgtc tcaaaagacg gacatcatgt 1328581 agagcttgca gcgaacatcg gtactcctga tgatgtaaaa ggtgttcttg aaaacggcgg 1328641 agaagcagtt ggcctttacc gtacagaatt cctttacatg ggaagagatc agctgcctac 1328701 agaagatgag cagtttgatg cttacaaaac ggttcttgag cgtatggaag gaaaatcagt 1328761 cgtcgtgcgg acacttgata tcggcggaga caaagagctt ccttacctgc agcttcctaa 1328821 agaaatgaac ccgttcctgg gatatagagc gattcgtctt tgccttgaag agcaagaaat 1328881 cttcagaaca cagcttcgcg cgctgcttcg tgcaagtaca tacggaaact tgaaaatcat 1328941 gttccctatg attgcgacag ttaacgaatt caaagaagca aaagcgatcc ttcttgaaga 1329001 gaaagaaaag ctcgtaaaag cgggacaggc tgtatctgac gatattgaag tcggaatgat 1329061 ggttgagatt ccgtcaactg cagtcatcgc tgatcagttt gctaaagagg ttgatttctt 1329121 cagtatcgga acaaacgatt tgattcaata cacaatggca gctgaccgta tgaatgaacg 1329181 tgtatcttac ctgtatcagc catacaaccc ggcaatcctt cgcttaatta cactggtaat 1329241 tgaagcagca cacaaagaag gaaaatgggt tggcatgtgc ggagaaatgg caggagacga 1329301 gattgcgatt ccgatccttc tcggcttagg cttagatgag ttctcaatga gcgcaacgtc 1329361 tatccttccg gcaagaacac aaatcagcaa attgtctaaa caagaagctg agtcattcaa 1329421 agagaaaatc ttatctatga gcacgacaga agaagttgtc gcgttcgtaa aagaaacatt 1329481 caagtaatgt acaaaaacca gacggcctcc ggcctgtctg gtttttttca taagtaaggg 1329541 tatagaagga cacaataaca tggctaggag ggatagtatg tcaaaccaat ttaacgcagg 1329601 agatactgtt tatgtgatct acagaaatcc gcacgccgcc aatgtagccc acataaagga 1329661 agccgaaatt gtgcaccatc cataccatga aggcgagctt tccctgttta tttatgaaac 1329721 ctatcatcca ttcgcagagg acgatgctgt gtttgcaagc tatgaagaag ctaaatcgct 1329781 ttacaaagaa ctgtttgata ttgatccgta tgagtaacaa ggaaatcatt acaactcata 1329841 tcctttccgc ctagtgagaa aagtaacgtt agtaaaggaa aaggatgtgg catcatgcag 1329901 aacccatttg ttccgcagct tgtgtatata gaaccgaggg cgctggaata tccgctgggc 1329961 caagaattac aagataaatt tgagaatatg ggtattgaaa tcagagaaac gacatcccac 1330021 aatcaggtgc gtaatatccc tgggaaaaat catcttcagc aatatcgcaa tgcgaaatca 1330081 actttagtta tcggtgtccg gaaaacatta aagtttgatt catccaaacc ctcggccgaa 1330141 tatgccattc cgtttgcaac aggctgcatg gggcattgtc attactgcta cctgcaaaca 1330201 accatgggat caaagccgta tatcagaact tatgtaaacg tcgaagagat tttagatcag 1330261 gcagataagt atatgaagga gcgcgcacca gagttcacaa ggttcgaagc atcatgtacg 1330321 tcagacattg taggaattga tcatctgaca cacacgctga agcgcgccat tgaacatttt 1330381 ggccaaagtg atctcggaaa gctccgattt gtaacgaaat ttcatcatgt cgatcaccta 1330441 ttagacgcaa agcataacgg gaaaacgaga ttcagattca gtattaatgc cgactatgtg 1330501 attaaaaact ttgagccggg aacttcacct cttgataagc ggatagaagc ggcagtaaaa 1330561 gttgcaaaag caggctaccc gctaggcttt attgttgctc cgatttatat tcatgaaggc 1330621 tgggaagaag gatacagaca tctgtttgaa aagctagatg ctgctttgcc gcaggacgtt 1330681 agacatgaca ttacgtttga attaattcaa caccgtttta caaaaccggc caaacgagtg 1330741 atagagaaaa attatccgaa gacgaagctc gaattagatg aagaaaagcg ccgttataaa 1330801 tggggccgtt acgggatcgg aaaatatatt tatcagaaag atgaagagca tgcacttcga 1330861 gaggcacttg aatcctatat tgataccttt ttccctaacg caaaaattga atatttcact 1330921 taaacgggct gttgtgatca acagctcgct tttttataaa aaacattttt ccattccatc 1330981 aaaacgccgt aattcaatga ttctttatcc tccaaataat tgctgactac acgaataggt 1331041 gaacgcccgc aacggaggag aaaggacagc acagggtcgt ttttcctgcc ttccatcaca 1331101 tcttcaacgt actgaacagc gctgatctcg tgtgcgtatt tataatacaa aggaatgcgg 1331161 ccgccgccga gaaggcgttc cagtctttta tcaacagtca gctcatacat cgtattcatc 1331221 agccattttc cgattccaag ctttcgataa tgaggagaaa cagaaatatc cactacatat 1331281 aaagtatttc catgaggttc atgattttta atcgatccgt tgtcagttgc ttgtgcccat 1331341 gtatgatcag gagaatcagg ctcaaattgt acaataagag cagtcatgga accgataatt 1331401 ctgccattga tgagcgcgca taaagcgcct tccggaaagg ttttgatatg gctggcaagc 1331461 tggtcctctg accacagcaa ttcctgggga aacggaggag ggaaacattc ttcttgaaga 1331521 gaaatcagcc tctcgatgtc agtctcagtg tagtttctaa tggtcagagc ctcaaatttt 1331581 ctgccgtcat gcacatacat ttgttttagt atgatcatca ctctccttat gttgtttcat 1331641 tataacgaag attgaatttt cagtaaatat attccgattt tcttataatt tattttttga 1331701 ttattcattt ttcaaacgaa agggccgata tagaaattag gaggggattg gtttgtttaa 1331761 aaaacttcac atgaagattg ctgtttttgt ttcgattatg ttaatcatca cagttgttct 1331821 cttaatgctg tcttcttatt tgacgctaaa accgatgatt acagaggatg ggaaaaatac 1331881 aactcaaaac gtgacgcagt cacttgaaca aaatattgaa ttgcaattaa agagttatgc 1331941 catttcgtta tcaagattgg ctaatgggga attaacgcat acatttgtaa cgaaaccaag 1332001 taaagaagct tctcggctgt ttcacgatga cattaagcaa atcaaagaca acgatgatta 1332061 tgttgcgatg gcttacatag gcaccgcaaa aaaagaaatg tttacatatc caaaagcgga 1332121 tttcgctgag gattacgatc caacatcaag accatggtat aagcttgcag ctgaaacccc 1332181 ggatcaagtt gtttggacgg aaccttataa agatgtcgtg acaggagaca tgattgttac 1332241 tgcatcgaaa gcgatcttag acaggcaaaa agtgataggg gttgccagct atgacttgaa 1332301 actctctgct atccagagta tggtcaataa acaaaaggtg ccttacaaag gatttgcctt 1332361 tttagctgat gcgagcggca atcttttagc ccatccgtca aatcaaggaa aaaatatatc 1332421 aaaggatcaa acactgcaaa ccatcgcatc cgagaaaaaa gggatacaag atgtgaatgg 1332481 gaaaatggtt gtgtaccaaa cgattggcga gacaggctgg aaggtcggaa cgcaatttga 1332541 taccgatcaa ttaatgtgga tttcagataa aatgaatcgg gccaatcttt ggatatcatt 1332601 gattgcgctt atcataacaa ttattctcag ctacttcctg gccaaaacga taaccggtcc 1332661 gatacagcag ctgatcgtaa aaacgaaagc tgtttccgca ggcgatttaa cagtgcgcgc 1332721 ggaatcaaaa tctaaggatg aagtcggtat tttaacaaga gatttcaatc tgatggttga 1332781 aaatatgaag gaaatggttg agcaagtgag actctcttca gggaaagtat ctgacacctc 1332841 tgaacaacta acggctgtgg ctgccgaaac taatgaaaca agcggacaaa ttgcaaaagc 1332901 gattgaagaa gtagccgcag gggcatcgga acaggcttct gaagttgaaa ccattaatga 1332961 aaaatcggaa agcctgtcaa cgaaaatcag gcaaatcgct gaggaggcag gcggaattaa 1333021 agaacgctca aaatcgtccg aggatgcaag ctataaagga cttgacgcgc tcggccagct 1333081 gctgatgaaa tcaaacgaag ccaatatgga aacgaaaaag gttgaaacga tgctgctgga 1333141 tttggaaaat caaactaaga atattgaaga agtcgttaca gcgatttcaa acatatctga 1333201 tcaaaccaac ttgcttgcct taaatgccag tattgaggca gccagagccg gagaaagcgg 1333261 gcgcggtttt gccgtcgtag ccgatgaagt gcggaagtta gctgagcaat cagccctttc 1333321 tacaaagcat atcagcgaga ctgtgaagct tatccagctt gagacaaaag aggcctctca 1333381 cgcgatggtt gaggcaagca gaatgaatga tgaacaaaac agtgcaattc acgaaactgg 1333441 agaggtatta aatacgataa ctgcagaaat gcagtcactg gtacaaggta ttgatcacat 1333501 ttacgcggaa attcaaagaa tgagtgaaga acagcttgcg atttctgaag ccattcaaag 1333561 catttcagcc atatcacagg aatcagctgc cgcagcagag gaagtgaacg catcaaccga 1333621 tgaacagctt gtcacccttg ataaagtcaa acactcaacg gaaacactaa aacatgcaag 1333681 ccaagagctt atgaacacaa ttgcaaaatt cacattgtaa tccaattaca tccccaaaca 1333741 tcatttgttt tggggatttt ttattttata agatgaatag atatggtagt ctagaaaatg 1333801 aaggaaaaat gataaatttt aactaaaatc taaacgaaac atctgggagg aatgaccttg 1333861 aaaaaaacaa ttggttttat cggtcttgga gtaatgggaa aaagcatggc atcacatatt 1333921 ctcaatgacg gccatcctgt attggtgtac acccggacaa aagaaaaagc agaaagcata 1333981 cttcaaaaag gcgcgatctg gaaagatacg gtcaaagatc tttcgaaaga agcggatgtt 1334041 atcatcacaa tggtcggcta tcccagtgat gttgaagaag tgtatttcgg aagcaatgga 1334101 attattgaaa acgcaaaaga aggtgcatat cttattgata tgacgacatc taagccttcg 1334161 cttgcgaaga agattgctga agcggccaaa gaaaaagcat tgttcgcttt agacgctcct 1334221 gtttccggtg gagacatcgg tgcacaaaac ggaacactcg cgattatggt cggtggagaa 1334281 aaagaagctt ttgaagcctg catgccgatt ttctctttaa tgggagagaa tattcagtat 1334341 caaggaccgg ctggaagcgg acagcatacc aagatgtgca atcagattgc aattgcagcc 1334401 ggtatgatcg gtgttgctga agcgatggct tatgcccaaa aatcaggcct agagccggaa 1334461 aatgttctga aaagcatcac aacgggcgca gccggaagct ggtcattgtc aaatcttgct 1334521 ccccgtatgc tgcaaggcaa ctttgaaccg ggattttatg tgaagcattt tattaaggat 1334581 atgggaattg cactagagga agcagaatta atgggggaag aaatgccagg cttgtcgctc 1334641 gcaaaatctt tatatgacaa gctagctgct caaggtgaag aaaacagcgg aacacagagt 1334701 atatataagc tttgggtgaa ataaaaaaag attgcctgta cgaaacaggc aatctttttt 1334761 tattattttc cgatgaattg ttgtgtccag atgcttccag actcaacgta accaacaccg 1334821 atgtgagtaa agttagggtt tagaatgttt tttctgtgtc cttcactgtt catccaagct 1334881 tttactactt cttctggtgt cttttggccc ttcgcaatgt tttcacctgc tgttttgtag 1334941 ctgattccga aagatttcat catatcaaac ggtgagccgt atgttgggct ttggtgatca 1335001 aagtagtttt tgtctttcat atcctgagat tttgcgcgtg cagatttgct taacgtttca 1335061 tcaatttgaa gcggttttaa gccttgtttt tgtctttctg catttgtaag ttcaacaact 1335121 tttttctcat atgcacttac agatgaaggt gcagacgttg ttgtgtttgt tttttcagca 1335181 gttgcgggtg ctttagaagc agtgttttga tcagcagctg ctttttcagt agtcttttgt 1335241 gcaggttttg ccgtttctgt cttttgaaca tcctgaactt tcacgttaga ttgcttcgca 1335301 tgtttttgaa gaagctgctt catctctttt tcgtttgcag cgtttaacgt tttgatattt 1335361 gtgttaatat gcagtttttt cactgcatcg ttaagtgaca tgttttgtac tgtgttcccc 1335421 gtttttactg taaccacagg ctggcaggag agttctttcg ctgatgcttg ctgtacgccc 1335481 ccgaatgtga ataatccaac cgcagcggca gcagataaaa taaatgcttt cttcattagt 1335541 tcgtaacctc ctagagttgt ttgtttctac agaaaaatca taacatagct tttttgtcat 1335601 aaagattcca gcactttcct ttgacaaata gagattgtca ttttcgtaaa gtaaatccgt 1335661 tgaatcacta agaataaggg aatcagcggt atatatgatt ttatcgtacc gttacatagc 1335721 ttcctttttt ttgaaccgtt agttatattt taatgtgttt ttatattgac agcttttttt 1335781 actccttttc gctgtaacaa ctattacaaa ggtgttacaa ttaatctcag tatatgtaaa 1335841 tatattgaat gatttgagag gggtaaccag aagtgactga aataggacgt gaaccaaaga 1335901 aaaagagcaa aggaaacaga gcaatcagaa tgaacctttt tttcctagct gtctttgttc 1335961 tattcactgc attaattttt aagctcgggg ttgttcaaat tgttgaaggc gaacagcatg 1336021 aagaagacgc tgagaaatca aatgcaaaaa cagcttacta tcctgcgcct cgcgggaaga 1336081 tgtacgacag aaaccagaaa gttgctgtcg acaaccagag cgttccagaa attgtgtatg 1336141 tatcaacatc tagcacaaaa acagaagata aaatcaaaac agcgaagcgg cttgcttctt 1336201 tcattcatat tgataccgaa tttttgaagg aaagggatct tcgtgattac tggatcgcag 1336261 ctcatccgaa aaaagccgcc gctctgctta aggaatcaga aagcaatctg aaaggagacc 1336321 aggcttacaa gcttcaaata gagcgtgttc cggatcaaga attaaaggct attcagcaag 1336381 atgacgaaga aatggaaact gctgcgatat atacaaggtt ttcaagcgga aatgcttacg 1336441 aacctcaaat cgtaaaggca atgaatccaa ataagagcaa tagcaatgga aaaaacggag 1336501 cgctgcttga tgagaagaaa aactcctcgc aaagaccaaa aaatgactta acatatgatg 1336561 aaatttccat tgtttctgag catttagaag aacttccggg aatcgatatc gtaaacgatt 1336621 ggacacgaaa atatccttat gacaaaaccc tttattctgt tttcgggggc gtcacgacac 1336681 ctgatcaggg cctgctgagc gaccggaaag atttctactt aacaagaggc tatgcgaata 1336741 atgacagggt gggaaaaagt tatttagagt atcaatatga agaatattta aattcgcata 1336801 aagaaaaagt ggaatacgta gaagataata aaggaaatgt cgtcagccaa aaaaccattg 1336861 ataagggcag caggggatac gatcttcagc tttcttttga catggagctt caggcaaagg 1336921 tagaaaagat cattgaagaa gaagtaagaa acagccgtgc acgcggaaat tacatgcttg 1336981 acagagcctt tgccgtaatg atggacccga ataacggcga tattttatca atggcaggga 1337041 aaaagataga tttaaaaacc aacaaaattg aagattatgc gataggggca tttaccaccc 1337101 aatatgaaat gggatcagca gtaaaggggg ccaccgtgct agccggctat caggacggga 1337161 tcccgcatta taaatattat atcgatgctc caatgctttt aggaacgaat cttataaaaa 1337221 aatcttatac taatatggga accatcaatg aattaaccgc attgcaaaaa agttcaaacg 1337281 tatatatgtt caatgttgcc atgcatattg caggcgtaac atacaagccg catggatctc 1337341 tcccggctga tcagaacgat ctactgaaaa tgagaaacta ttacagccag tttggtctgg 1337401 gagtaaagac aggtattgat ctcccgcagg aatcagccgg aatgcaaacc acacctaaaa 1337461 ctgtaggagg attaatttta gacttagcaa ttggccaata cgatacatac acaccgcttc 1337521 aaatggctca atacatctca gtaatcgcca atggtggcta tcgtgttcag cctagaatcg 1337581 tcacaagtat tcataagcca ggaaaaaaag accagctggg taaggcgatt gaacatagga 1337641 aacctaaagt actcaataag attaataatt cagagagcga tttgaaacaa gtacaaacag 1337701 gcatgaaatt agtcacttct tcagggacag caaaaaatac gtttacagaa gatgtatcag 1337761 ggaaaacggg aacagcggaa acattttact acggcacgaa tcgcaactgg tgggggaaaa 1337821 aaacatacaa tctgactttt gtcggctatt acccgtcgaa aaaaccaaaa gtggccttta 1337881 gtgttgttgt tccatcagta gatgatgatg ataagatcaa taaaattatt gccaaaagag 1337941 ctatccacgc ctacgcagag ctcgaaaaaa aacacagtaa aaaataaaaa acagggtgca 1338001 caactaaaag attgtgtgcc ctttctttta ttcaaaaatt gacgttcacc ataagaatag 1338061 aaggagaata ctcattttct agcgaatcat actaggtaaa agtcaatctg tatatgtcga 1338121 aacacgatga tcatgcaaag gagggattct gtggaacagg atacgcagca tgttaaacca 1338181 cttcaaacaa aaaccgatat tcatgcagtc ttggcctcta atggacgcat catttatata 1338241 tctgccaact ccaaactgca tttgggctat ctccaaggag agatgatcgg atcattcctc 1338301 aaaacgtttc tgcatgagga agaccaattt ttggttgaaa gctattttta taatgaacat 1338361 catctgatgc cgtgcacctt tcgttttatt aaaaaagatc atacgattgt gtgggtggag 1338421 gctgcggtag aaattgttac gacaagagct gagcggacag aacgggaaat cattttgaaa 1338481 atgaaggttc ttgaagaaga aacaggccat caatccctaa actgcgaaaa acatgaaatc 1338541 gaacctgcaa gcccggaatc gactacatat ataacggatg attatgaacg gttggttgaa 1338601 aatctcccga gtccgctatg catcagtgtc aaaggcaaga tcgtctatgt aaacagcgcg 1338661 atgctttcaa tgctgggagc caaaagcaag gatgctatta ttggtaaatc gtcctatgaa 1338721 tttattgaag aagaatatca tgatatcgtg aaaaacagga ttatacgaat gcaaaaagga 1338781 atggaagtcg gaatgattga acagacgtgg aaaaggcttg atggcacacc tgttcattta 1338841 gaagtgaaag catccccgac cgtctacaaa aaccagcagg ctgagctgct gctgctgatc 1338901 gatatctctt caaggaaaaa attccaaacc atcctgcaaa aaagccgtga acgatatcag 1338961 ctgctgattc aaaattccat tgataccatt gcggtgattc acaatggaaa atgggtattt 1339021 atgaatgaat cgggaatttc cctgtttgaa gcggctacat atgaggattt aattggcaaa 1339081 aacatatacg atcagctgca tccttgcgat cacgaggatg taaaagagag aatccaaaac 1339141 attgccgagc aaaaaacaga atctgaaatt gtcaagcaat cctggttcac ctttcagaac 1339201 agggtcatct atacggagat ggtctgcatt ccgacgacct tttttggtga agcggccgtc 1339261 caggtcattc ttcgggacat ctcagagaga aaacaaacag aagaattgat gctgaaatcg 1339321 gaaaaattat caatcgcagg gcagctcgcg gcgggaatcg cccatgagat ccgcaaccct 1339381 cttacagcga tcaaaggatt tttacagctg atgaaaccga caatggaagg caacgaacat 1339441 tactttgata ttgtgttttc tgaactcagc cgtatcgaat taatactcag tgaactgctc 1339501 atgctggcga aacctcagca aaatgctgtc aaagaatatt tgaacttgaa aaaattaatt 1339561 ggtgaggttt cagccctgtt agaaacgcag gcgaatttaa atggcatttt tatcagaaca 1339621 agttatgaaa aagacagcat ttatataaac ggggatcaaa accaattaaa gcaggtattc 1339681 attaatttaa tcaaaaatgc agttgaatca atgcctgatg ggggaacagt agacattatc 1339741 ataaccgaag atgagcattc tgttcatgtt actgtcaaag acgaagggga aggtatacct 1339801 gaaaaggtac taaaccggat tggagagcca tttttaacaa caaaagaaaa aggtacgggg 1339861 cttggattaa tggtgacatt taatatcatt gaaaaccatc agggagttat acatgtggac 1339921 agccatcctg aaaaaggcac agcgtttaaa atttcatttc caaaaaaata aaaacaacgg 1339981 cttaaacgcc gttgtttatc gtctgcattg cttcacgttt ttttaataca aataattcta 1340041 aacggtctag gccttctctc agcgtgtcca ttgagcatgc aaaagacagc cttacatatc 1340101 cttcaccata tgttgagaac gagctgcccg gcacgagtgc cacgccagcg tcttccaaaa 1340161 gagccatact aaaatcaaat gaagtcattc caaatgattt aatagaaggg aagatataaa 1340221 acgcaccgga cggtttaact acgtcaagtc ccatggaaac aagacggtca taaacatagt 1340281 ccagacgttt tttgtattgt tctctcataa tcaatgcatc gtcaaagccg tttgtgacag 1340341 cttcaagcgc ggctttttga gaaatggatg aggcgcacga cacattgtat tgatgaacct 1340401 ttaaaatgtg ctttgcaatg tctttcggtg caaataaaaa tccaattctc caaccggtca 1340461 tgctgtgtga ttttgacaac ccgttaatga caatcgtttg atcccgcaaa taggttgcga 1340521 tggagtaatg cggtctgtca tatgttaatt cactgtatat ttcatcagac aatacgaaga 1340581 catttctgcc ttttaagaga gctgcgatgc ttttcagttc ttcttcagat aaagtcacgc 1340641 cggtagggtt tgacggataa ggaagcacga cacacttggt gttgggtgtc agagcatctt 1340701 caatcagccg ggcggtaagc ttaaagccgt gtgacgtagt atcaacaatg acaggcttgg 1340761 ccccgcacaa attgataata ggttcatagc ccggataaat aggccctggc ataatgactt 1340821 catcaccggg agataaaatc gtccggaatg cagcatcaat ggcttggctt gcgcctgttg 1340881 tgatgataat ttcagattca gcatcatagt tgaaatccgc ttttttcttc atataaagct 1340941 gcacagcttg tctcagctcc aggtagccgg cattcggagt atatgacgtc acgttttcat 1341001 caatggcttt ttttgcggca gctttcacat gatgcggtgt gaaaaaatca ggctggccga 1341061 ttgtaagtga aatgacgtct tcgtgttggg ctacaagatt cgagaatttg cgtattcctg 1341121 aaatttcgat ctctcttgct ttcggattca gcaaatgttc cataattcat caccttaaca 1341181 aatataatga gtttatccta ttttaccact agctgatcat ttgtcacctt tttaactgat 1341241 atatttcgat tgtatgcgcc ttttttctaa acataccttt cttttcagaa aaaaagaaga 1341301 caaccagcga tttgattgtc tttattgtat catgttctat tattgtttat atgtgccaat 1341361 ttcattaata gccataatca aaatgaaggt cttcgtgcca aatcagatac ggaggatgct 1341421 cttcttgaag gtcagctgat tctttcttca tattcaggta agtttcttca ctgatatcct 1341481 ctaaaacagt catttcgttt tctttaaata ttactaaggt acccattatt tacacccttc 1341541 tttggaaaaa tccttgacta ttttatcact gttagttgga aagtcaatgg ttattaggaa 1341601 aaaagtttct tttttgagga acgcggcttg ttgccttcgg aattcgattt tgaagagctg 1341661 ccattcactt tttacaaatt acgccgatat atacagtaca atactgaatg cgaatagcga 1341721 gggattgaat tgtcgttaca acaatacgaa attttattgg attctggtac aaatgaatta 1341781 gaaattgtga agtttggcgt gggtgaaaat gctttcggaa ttaacgtcat gaaggtaaga 1341841 gaaattattc agcctgtcga ggtgacatca gtgcctcact cccatcagca tgtagaagga 1341901 atgattaaac tcagaggaga aatcctccct gtgatcagtc tcttctcatt ttttggagta 1341961 gagcctgaag gatcaaaaga tgagaaatat atcgtgactg aatttaataa acggaaaatt 1342021 gtttttcatg tcggctctgt ttctcaaatt cacagagtat cctgggaagc gattgaaaag 1342081 ccgacatcgt taaatcaagg aatggagcgg caccttaccg gtattattaa gctcgaagac 1342141 ctgatgatct ttttgcctga ctatgaaaaa attatttatg acattgaatc agattcaggt 1342201 gttgacacgt ataatatgca taccgagggc ttcgatgaaa gaagaactga taaaaagctt 1342261 atcattgtag aggactcacc gcttttgatg cgcctcttgc aggatgaatt aaaagaagca 1342321 gggtacaaca atatcgcttc gtttgaaaat ggaaaagagg catatgaata cattatgaac 1342381 cttgctgaaa acgaaactga tttatcaaaa cagattgata tgatcatcac tgatattgaa 1342441 atgccaaaaa tggacggaca caggctcaca aagctgctga aggaaaatcc gaaaagctca 1342501 gatgtgccgg ttatgatttt ctcatcgtta attacggatg atctgcgtca ccgcggcgaa 1342561 gttgtaggcg cagatgagca aatcagcaag cctgagatca gtgatttgat taaaaaagtg 1342621 gatacgtatg ttattgaata aataaaaaca gccgttgcca gaaagaggca cggctgtttt 1342681 tattttaaaa gtaactctcg ccaagttttt taaagaccgg tttatggtaa gctggctgct 1342741 ggcgatttgg cactagcggc ttttctttca tgccgacata ttcttgcaat aggtgtttcg 1342801 cttttgttaa agacatttga gctttaggat ttcgatacga ttgattaagt gtacctaaat 1342861 gcggaagatg ttcgaagtct tctttagttg gaggcatgtg aaaatagtag tctccgattg 1342921 agataagcac gtccgattgc tgttggctga accttggatt ttttgaaaaa tgaagcccta 1342981 ttttctttcc tttaccttct ttgacaagct tttgcaaagc ccgttttttc agcagatata 1343041 ggtatttagg gttgggggcg gtttttgcat ggcggttcac agtgtaaact gcttttgaaa 1343101 gattttctac ggttggctgc agatctttcg tatatgcatg gtcgtccatt atttctctcc 1343161 tttgctctta tcaatttcta tatgtttaga ttatactttt ttaaagttga aatgcaaata 1343221 ttgaatgtaa aaatgcgctt ttttctaaga aaaaaagcgc atttttaacc tgcattatac 1343281 agatcttgcc ttctttttcg gctgttcttg aaatgcttcc tgaacattca cttccacagc 1343341 ctgagcactg tattttggca gtgcaataaa ataaaaaata aaaacgagca ggataataac 1343401 acccatgccg taataaagat aatcaatgtt tgaaacaaac ttagggaata acagcgcgac 1343461 taagccgagt gtcaaagatt gtgcaaacat cataaaaggg tcctgcatgc cgcttacacg 1343521 tcccatcagt tttggatgaa caatttttgg catccaccct ccgattgcaa tgttgatcgg 1343581 tccgatacac attcccagtg caaaagctgc cgcgtaatac acccataaaa tattggtgta 1343641 gccgaggacg aagatcagca aacctgcaat gaaaatcggt atcgacatta aaaagtgcgg 1343701 cttcactttt ttagagatga gcgtgccgat tacgcttcct gccagaagcc caaacccgag 1343761 tgcgatcgta aatacagacg tatgccactc ataacggtca ggcgccaatc catatttcat 1343821 tgtaaacatc ggcaatacgg cgaatcctcc attgacaaat ccaaaaatga agaagccaaa 1343881 aataagagat gccagcaatt tgttttttaa aatatagagg atgccttctc taaagtcatt 1343941 tattgaatcc ttaacagaag tctttctcca gctgaatgca ccgtttggct gtcgggcttc 1344001 ttttggaatc cggcagctgc ggatcagcag cccggaaatg ataaagctga caaaatcaag 1344061 aataatggcg ccttcaatac cgattgtgtt gtacataaac gcgcctatgc cgactccaaa 1344121 caccataaaa atgctaaaaa gcatctgatt aagccctgcc gctttcgcat aatgctcctt 1344181 cggcagaatg gcttgtacca aactgttttc tgccggaaag aaaaactttg ttacagcgct 1344241 tctgataaat aagatacaaa aaacaagagg aatattgccg gtaaataaag tgaaaaaaag 1344301 cacgacagtc aggcctgctc tgatccaatc acaattttct gccacctttt ttctatcaaa 1344361 ccggtccgcg acgactccca cgatcagaaa tacaaatatg gtcggaagag aatacatcag 1344421 ctccgccaag gtcgtatatg aaggctggct gctgaatcgg tccagcaaaa aaaaagcaaa 1344481 ggccatgttg cctactgtcg tgcccatttg agaagcgagt gctgcgaaaa atagacgaac 1344541 aaaattacga tttttaaata tatccataaa aacgctcctt accctaaagg tcccacttta 1344601 tcatattata aaccgcctgt ttttgaaaca aataagaaaa cattaccggt taatcgtgac 1344661 tctcgttccg tttggcacaa ttgaagcaag ttcgatcacg tctttgttat gcatgcgaat 1344721 gcagccttta gaaacagcct taccaatcga agcgggatta ttcgtcccat gtattccgta 1344781 gtgctgcttt gaaaggctca gccaataagc gccaaatggg ccgccgggat tgcgctggcg 1344841 gttaataatg taaaactcgc cagtaggcgt ttgcgttagt attttaccaa cggcgatggg 1344901 ataggttttc attacccgat tatttaggga cagcgtaagg gtcttcgctc cgattgagac 1344961 tgcgatatga tacggaattg tataagggtc cggcagtccg gggatgacta tggactgtcc 1345021 cgcggtgagc cctgcctgca gtgacggatt agcctggagt aatgcagccg tgctgattct 1345081 gaaatcagcc gcgatgctgt tcagtgtatc accttgcttc acctggtacg taagcagttt 1345141 cctcatcctc cttttttact tataagtatt gatgaggagc ccatcctgct acattaattt 1345201 gtgcttttta aggtgaagac agtgatttca ggcttggcaa gaaaccgcaa aggcagcctg 1345261 gtcatcccga ggcctcggtt tacgtaaata tgagtgctgc ccgtttgata cattccctct 1345321 gtgtagactt ttccatatgg aggcgtaata atcggtccgt aaaaaggcag ctgaatctgg 1345381 ccgccgtgtg tatggccgga aagctgaagg ttcacgggat aatctgttgt tttcaaggct 1345441 gcatcaggtt catggacgag aagaatggaa aaaagtctgt cgctcagcct tgaaagggtg 1345501 ccttcataat ctgggtttcc cagcattaag tcatcaagcg aagcaatctc gattttgctg 1345561 ccatctgcga gtgacaatgt ttgatagcca ttgcgatata ccgtgaaacc tccggccgtc 1345621 atcaggcttt tgtaaacggc agttccatag cctccgtgat catgattgcc gtaaatacaa 1345681 agcttgccga agggagcatt aagctttctc aataatggaa tgactgcctg gtggtgctgg 1345741 tacgtatcag gattatcaat aatatcacct gtaaaaacaa tgagatcagg tttagattca 1345801 ttaattgtaa gaatgacagt ttttaaatct tcgagagtaa agtaatcact caagtgtgca 1345861 tcgctgaact gcacgatttt aaaaccgtca aatccgtgcg ggatgagaga gctttttatt 1345921 gtgtgttcgg ttgtctcgat catatgcggc tcgagatacc tggcatagcc atatcccccg 1345981 ccggccgtta aagccccggc agcaagagcg ccgaacattc cttttagaaa ttgtcttctg 1346041 gacatctttt tcatttcaaa ccaaccttta atagagtttt tctattatat catctgtatc 1346101 tgataaaaat ctcatatgag catgtgctga cagaggcagg gatataatga tagaatatta 1346161 ttgaatgaat aatcattcac aattggaggg ataaacatgg aaaaaaaggc ggtaattatt 1346221 accggcgggt caagcggcat gggaaaagcg atggcaaaaa aacaggctga attagggtgg 1346281 cacgttatgg tgacagggag gaaccatgag gcacttgagg aaacaaaaaa agaaattcag 1346341 acctttgagg gacaggtcgc ttgttttcaa atggatgtcc gttccgattc cgccgcttca 1346401 gacatgatta aagaagcggt aaaagccttt ggccggcttg acgcgctgat taacaacgcg 1346461 gccggaaact ttatttgtcc ggcagaaaag ctgacgccca atggatggaa agccgttatt 1346521 gagattgttt taaacggcac atttttttgc agccaagcag cggcaaggca ttggattgac 1346581 cagaagcagc agggtgtcat tttaaatatg gcagccacgt acgcttgggg agcgggagcg 1346641 ggggtcgttc attccgctgc agccaaagcg ggggtattgt cattgacaag aacgctggcc 1346701 gttgaatggg ggagcaaata cggcattcgt acaaacgcga tagcccccgg accgattgaa 1346761 cgaacaggcg gtgcggagaa gctatttgaa tcggaaaaag cgatggcccg cacgatgaac 1346821 agtgtgccgc tcggccgatt gggcacaccg gaggaaatcg ccgctttggc agcgtttttg 1346881 ctttctgatg aagcatccta tataaacggg gattgtatca caatggacgg ggggcaatgg 1346941 ctgaatcctt atccgtttta atctgaatat ttataagtga atatttaagt tattaagaac 1347001 ttttatgttc gaatgtaata cctccacaat taaccttctt cctatccaat ttgataacac 1347061 atagagcttt atttgtttat gaggtgttgt gtcatacgta agccacctaa tatatgaaag 1347121 gtatatttta aaaggggaga cgaaatatga agaacttaga tttcaaataa aacattcata 1347181 taattacttc gttaactaaa aagagaaatt ataagaatga aaggtttcaa ggttacatca 1347241 gattgggagg aaggtaatat aatggacgag atggtattat taactcagga atggctcaat 1347301 gaaacgtaca aaggaaaaag tggctacaat tccattgagg aaaatgggaa aactggctgg 1347361 aaaacaatgt atgcattaac tagagcatta caactagaat tgggaattac acagacttcc 1347421 gacagttttg gtcctacaac tttaagaaag cttaaagaat taggcccgat ttctacgtca 1347481 actaattcaa aaaaaaatat tgtgaaaatt attcaaggtg ctctttattg taaaggttat 1347541 ggtccaggtg gattaacggg tacatttggt cagggaacga aagaggcgat agcagaaatg 1347601 caattgcata tggggctttc taaaacagac ggtgtagtaa cgcctaaggt gtttaaagct 1347661 ttattaaaca tggactctta tatcctttta aatggggcgt cagagaaagt tcgttcaata 1347721 cagcaatggc taaataataa atattacaat agagagaatt tctactttat gccctgtgat 1347781 ggcctgtatt caagggatac tcaaaagtct cttgtttatg caatacagta cgaggaaggg 1347841 ttaagtgata gtatagctaa tgggaatttt ggaccaacta ctcaaagatt gattcctgta 1347901 ttaagaattg gagaaacaga tgaaaaaaac agttttattc atttatttca agctgctcta 1347961 atctttaatg gctacaatgt tccttttgat ggagtatact ctgaatctgt aagatcaaaa 1348021 gtaaaggctt ttcagtcttt tgcaaaatta caacagagtg gtactgccga ctttcaaaca 1348081 tgggcttcac ttctagtaag tactggagac cccaatcgaa aaggagttgc ttgtgactca 1348141 attactcaaa ttacatcgga cagggcggag tcccttaaga gggcaggtta taagattgta 1348201 gggcggtatc taacaaatgc gccggggagt acactaaata aaaaaataca accaggtgaa 1348261 ttagaaacta tcttaaaatc aggtttaaat gtttttccga tttatcaaac ctatggggga 1348321 gcaacaaatt attttaataa agaacaagga aagaaagatg cgtttgctgc ttataaagca 1348381 gcaaaagaat acgggtttaa aaataacact gtaatatact ttgcagtaga ttatgatgca 1348441 tatggtaacg atttaaacaa caatattatt ccacacttcg aaggtataaa tgaaataatg 1348501 aacggttttt taggttcaac ttacaaaatt ggtatttatg cccctaggaa tgtatgtact 1348561 atagtttcta aaaaaggttt agcatttgca agttttgtaa gtggtatgtc tactggcttt 1348621 agcggaaact taggatatcc tttgccttac aattgggcgt ttgaccaaat ttcaacaatt 1348681 actgttggaa atggttctgg aatgattgaa attgataatg atatttgttc aggtttggat 1348741 aatggagtta ataccataaa tatagtgcct tcagagaata agaagttttt tgatcaaatt 1348801 gatgttttat atgaaactgc tgaaaaatat gctcaaatgc aaagcgactt aaataatggg 1348861 gtaaaaaaaa cacaattagc taatgagttg gttgcccagt atttaagaaa ggatgactac 1348921 aaagggtgga agtgggtccc taccgcaggc cagattgatc ctatttatcg tgaatgggca 1348981 gtaaagcgct aggggaagac ctagtaaatg gaattgttga tcctatatca aaaactgtca 1349041 taggaacgca gcatcttatg gcaacttata atgccattat ttatagtggt ggttactctc 1349101 aaacactacg agattttgct ggttggactg gagatctatt aacaacaata caggacatga 1349161 aattacacgc tcaagaattt aattcgcctt atgatgcggc tatgaaaata ataggtaata 1349221 tgtatcaatt tagcctagat gatttattta gtgatgtaga tgcaattaat ctagcgaata 1349281 aaacatcagt tggtgctaat gcacaacctc taaatatcgc aattagagat tattatagta 1349341 ataatgactg tatgaatagg ttcactcaat ttgtaaataa tagatttgat ggttcgttag 1349401 acaaaatttt ctctgaagca gagtattatt taaatacaaa ccttgaccca gttgttgttc 1349461 caattaggtt agcctttaaa cgtgcttttg atgttgagga ttatagtgaa gagattggaa 1349521 aaataacagc acaagcattt agagatgtta tcgagaaaaa aatgatatct gaataaactg 1349581 caaaacaagc gaacgttaaa actggtcgtt cgcttgtttt attttctatt taaatttatg 1349641 atataatttt taaagattaa ggagtgattc attgaagaaa ttgttaaaaa agttagttgt 1349701 attattttta agcagtttag ttatcatctt taatgtttgg tactttatta tttgtgcttt 1349761 ttccccagag tattatcaaa atacaaatct tacttctaat gaaataataa gatttgaaaa 1349821 actataccac atagattttc ctgatgaaac aaaatttatt aaagctagag agtatttggc 1349881 tgggcccgga ggagatacgt cagctgtatt atatgtgtct ctgccaacca agcgggtaga 1349941 aaaagtttta tctgattaca cgtatatgaa aataaactat actgacaatg tcggttcaat 1350001 gtatggagtt gacgtttcaa agagtgtcgc cggtttaaca actcttacat ttggcactta 1350061 cgataaaaaa ggaactttct ataatatgaa acatgatgat gattggatgt ataaaggcac 1350121 tgactggaat ctttactttt ggacagctgc tagttataat gctgttattt ttgtatttgt 1350181 tttggttatt gtgaaacaaa tgaataaaat tcttaattaa ccagtatgta gattgataat 1350241 ctcaaaaaaa ttttcctctt cttttaacat actccatacg acctactttt ccatactatg 1350301 atttttttga aatttgtggt gtagttataa ttgtgcgtat aatcagacaa agatagagaa 1350361 gcaggtgata acatgttgga tccacttgat attttaacga acattgatga tgtccttcca 1350421 tattaccagg cgatttttag tgccgaggag cagaaggttg tcggatatga ggtgcttgga 1350481 cgaattttgg cagattcaga aatccaaagt ctcgggccct tctttttaga tgcggggata 1350541 cccgaagaat ataaattaga ggttgataac agaattatcc gccaggctct tgaccgcttt 1350601 ttagaggcgg attctgatct gctgattttt atgaatcagg atgccaatct gctgatgctg 1350661 gatcatggtg aaagctttct ggagcttctg aaagaatatg aagcgaaggg aatcgaactc 1350721 caccgttttg tgcttgaaat tacagagcac aattttgaag gggatattga gcagctctac 1350781 catatgcttg catactatcg tacatacgga attaaaatcg cagttgacaa catcggaaaa 1350841 gaaagcagca acttggacag aatcgcgctg ctctcaccag atctgttaaa aatcgatttg 1350901 caggcgctga aagtgtcaca gccgtcaccg tcatatgagc atgtgctgta cagcatatct 1350961 ttattagcaa gaaaaatcgg tgcggcgctg ctgtatgaag acattgaggc gaacttccag 1351021 cttcagtacg cctggagaaa cggaggccgc tattttcagg gctattactt agtgtctcca 1351081 tctgaaacgt ttctagagag agatgtattg aaacaaagac ttaaaactga atttcaccaa 1351141 tttatcacac atgagaaaaa gaaactggag accgtctatg agcactctga acagttttac 1351201 aaacgagtgc atcaggctgt gacctctttg agaaaaaaca atctgtcttc tgatgatgac 1351261 tttattaaaa agctggcgga agagctgaca gattgcagct tcaggattta catgtgtgat 1351321 gaagaaggcg atcagctgac gggaaatgtg tttaagcaag atggagaatg gatttatcag 1351381 ccggaatatg cggaaaagaa ctggagctgg cgcccttatt ttctggagaa cattatgaga 1351441 atgagaaatc tcagaaaagg ttttttcagt gatctgtaca gtgatttgga aacaggtgaa 1351501 atgatcagaa cgttttcata tccgatggat gatcagatgt atttatttat agacttgcct 1351561 tattcttatt tatatgagca ggacggactg atttaacggc tgaaaggccg ttttttttat 1351621 gaaatgaaaa aaatatcaaa aaacgattga cattgatact gagaatcatt atcatttaat 1351681 tatagagaga agctactctc tgttccccaa cccctctatc agatcaagat ccgaaaaaac 1351741 ttggcgctac ccccgccaag ttttttattt gtcaaagcat aggacaatcc aatgaaacaa 1351801 taaacctaac tagtggtaaa cgtttaacac ggggagaaac attgagtgcc gaacacccct 1351861 gacactgctg cacgggtgag gaggaaaatt cgttctgaaa tgattatttc agttccgttg 1351921 tttacctcta tccagcatga ctcccattga ttatggccac gcgggacttc accataaaat 1351981 tcaaaagaag gttttgacaa agttgcaaaa aggcattctt aatgctgcca aagattcgaa 1352041 aaaaattata attatgtgca tgacattcaa aaaaagcctc aaactaaaga aaaatagttt 1352101 ttttcacttt ttttctttgc ttaaattcag cagtgaaaat gccatcctgt ccgactttat 1352161 ggtatgatgc tcaatagaac ttgtattata ataaatactt gttgatttga agttgctttt 1352221 tgaaaggagt ctttttttag aatgtcacaa ttaatgggta tcatcacacg gctgcaaagt 1352281 ctgcaagaaa cagcggaagc ggctaacgag ccaatgcagc gttatttcga agtgaatggt 1352341 gagaaaatat gcagtgttaa atatttcgaa aaaaatcaaa cgtttgaact gacggttttc 1352401 caaaagggtg aaaaacctaa cacatatccg tttgataata tcgacatggt ttccatcgaa 1352461 atctttgaac ttcttcagta agattcctga aataggggga acaagcttcc gcctttgcaa 1352521 aagtaatcga aataaacggt aaggaacata cttgtttcat ggttgtaaat ccttgaaaag 1352581 gagtgtcgtg atggctgatt cttttctgtt ttataatctt tcagaagcac agatgacctt 1352641 tcaagatgtg atggaacggc ttaaagcctt tgttcaaaag gacccccgtt cttcttatgt 1352701 gttatcgatc ggaaccgatt cacaggttta ccgcgattac acaaagttta ttaccgcatt 1352761 gcatttgcat cgtacaggca agggagcttg gggctgcttg aaaaatcata cagtcgacag 1352821 acccatacat agccttcggg agaagatttc gttagaaacg gcgtacagcc aagaaacggc 1352881 cgctcatatt cttgatggac acttaatgga tattaccgat ctgctcctgc cctttaccgg 1352941 tgagggggcg gatcttacct ttgaagttca cttggatatt gggaaaaaag ggcttacaaa 1353001 agatctgatc caagaaatga ctggacgtat tacctccatg gggattgagg ccaaaataaa 1353061 gccggattca tacactgcct tcagctatgc aaatcgtttc acaaaataat ttggctgaaa 1353121 aagccaaggt aaatgtcgaa ttatgcggtt gacgtttgtt atctgattac ttattctagc 1353181 ggtagagctg aaagtaagtt gtcttgcttt cagaggtatt cagtataaaa cagggggcct 1353241 gattgcgaat gagtcttatc ggtgaacgat ttacagaaga agaacaaaaa cttctgctga 1353301 atatcctgat caaccatgag tatgccatcg agctattaag cagtgagatc aacgatatag 1353361 agacagggac caaaaacgtt gacggaacca cctacaaaaa acttgtaacg ctatacgacc 1353421 gatttcgatt tgaaaattaa tgggacaccc tataattgat actccacaaa gagtatcttt 1353481 tttattgaaa ggaaactttt cgacaaatac tgataaagtt tatattattg caatataggg 1353541 aatgtattga tgatgaaaat gaaaaggggt cgaaaacatg ataagcttac aatcagatca 1353601 acttcttgag gcaacagtcg gacaatttat gattgaggcg gacaaagtag cgcacgtgca 1353661 agtcggaaat aaccttgagc atgcattatt agtattgaca aaaaccggat acacagccat 1353721 cccggttctg gatccttcct accgtttaca tggcttaatc gggacaaata tgatcatgaa 1353781 cagtattttt ggacttgagc gaattgagtt tgaaaagctt gaccaaatca ctgttgagga 1353841 agtcatgctg accgacattc cgcgccttca tatcaatgat ccgattatga agggattcgg 1353901 catggtcatt aataacggat ttgtctgtgt tgaaaatgac gagcaggtat ttgaagggat 1353961 ttttacgaga agagtcgttt taaaggaatt gaataagcat atacgctcat tgaataagta 1354021 ggctgtacgg tcctattttt attatatagg cagagtgaaa aaagaaagcg catacataat 1354081 ttaaacgaga atagggcttg aataagaaac taagatttta ttagaatggg agataagaaa 1354141 aacttattga taacaaaaag gaggacgaca tgcagcttca agagcttcat atgctcgtag 1354201 ttttagctga ggaattaaat atgagaaagg cggcagaacg gctttttgta tctcagccgg 1354261 ctttatctca gcgcttacaa accattgaaa aggcgtgggg aacaaaaatc tttttaagat 1354321 ctcaaaaagg attaacggta acgcccgccg gtgagaaaat cattcagttt gcgaatgatg 1354381 tgacattaga gcaggaaaga ataagagaaa atattgacga gcttgaaggt gaaattcacg 1354441 gcacattgaa gcttgccgtc gcctccataa tcggtcagca ttggctccct aaagtcctga 1354501 agacgtatgt ggaaaagtat ccgaatgcaa agatctcgct cataaccggg tggagcagcg 1354561 aaatgctgaa aagcttgtat gaggatcagg ttcatatcgg cattataaga ggcaaccctg 1354621 agtggaaggg gcgcaaagat tacttaatga cagatcatct gtatttagtg gatactgaaa 1354681 tttcctgcat cgaagatatt gcccatacag aacgtccgtt tatccagttt aaaagtgaca 1354741 gcacttattt tcaggaaatt cagcactggt ggcatcaaaa atttaaaacg tcgccgaaac 1354801 agacgatatt ggttgatcag attgaaacgt gcaaacagat ggcgctgcac ggaatcggtt 1354861 atgccatttt gccgtctgtt acccttcaaa atgaagataa agtgaataaa atgcctcttt 1354921 tagacatgaa agggcatccg atcggtcggg atacatggtt attaggttat gagcctgcct 1354981 ttgaactgaa acaagttcaa gcttttgtac aagtgataaa ggatatgctg gatcaggaaa 1355041 atccatttta aagacagcga ggtgctgtct tttttttatt tatctgttga caatgaaaat 1355101 cattatcatt taaagtgata catatgatat tgaaaatcat tatcaactaa tggggtgata 1355161 acatggctaa agccttgatt acatatgcca gcatgtcagg aaatacagaa gacattgcct 1355221 tcataataaa agatacgctt caggaatatg agttggatat cgattgtgtc gagataaatg 1355281 atatggatgc gtcttgttta acctcctatg attatgtact gattggcacc tatacatggg 1355341 gggacggcga tttgccctac gaagcggagg attttttcga agaggtcaaa cagattcagc 1355401 ttaatggttt aaaaacagcc tgcttcgggt ctggcgatta ttcttatcca aagttttgcg 1355461 aagcggtgaa tttgttcaat gtcatgctgc aagaggcggg agctgctgtt taccaggaaa 1355521 cactaaaaat tgaattagcg cctgaaacag atgaagatgt ggaaagctgc cgagcgtttg 1355581 cgagaggttt tcttgcatgg gcagattata tgaacaagga aaaaatccat gtttcataaa 1355641 ggggcaaccg ctgttacggc atcggcgttt tctggatatt ttgtggcggt acaaagagaa 1355701 ggcatttttc attactcttt ggagcagggc tggagaaagc tttttcgttt gaaaagtaag 1355761 atacactgta tcagctacat agggccttac ttatttggcg ttggtgaaaa gggaacagtc 1355821 attcgttcgg ctgatgaagg gaaaacctgg acgatgtcga gctttccgac aaatgcaaca 1355881 gtgtgggcga ttaccggcag aaacaacggg tttgtctgcg cccacggtaa gcattgtatt 1355941 tatgtatcgg atgattttgg tgtctcatgg cgcgtagcca aaccttttgc cgaatttcat 1356001 aatccccctg ttatccggtc gttatgcctt cacgggggca atctctttat cggcacgcaa 1356061 atacacgaat attttggcgg catttgggct tacgacatta agcgtgacac tgtccaagtt 1356121 gtcaaaaaag aaaaaaaccg gatgacggca tccatgctcg tgttcaatga aaattggctg 1356181 gtggcggcga tgggttctgt gaaaggaaag cacggtgctg tcactgtaag gaatcttttg 1356241 aatggtgaag aattcaccat acaatccagt atgatcagaa atgaagaatc atttcttgat 1356301 ctttcagagg atgatggcat tatatatgtc actacaacac aagatgaaaa tggtttttcg 1356361 agaatttacc aggttgatct cgaagcccgg tcgttaaaat ggttcgatac cattaaggga 1356421 catggatgga gagtggccaa tcagaaagag aatttctttt gcgcaggctt gtatgaatgt 1356481 aaatttgtcc agccgtacga agtttcagca atgattcatt agaggaggaa caaggaattg 1356541 gcgaagattt tgctcgttta tgcaacaatg tcaggcaaca ctgaagctat ggcagatttg 1356601 attgaaaagg ggcttcagga ggcgttagca gaagtagacc gtttcgaagc aatggatatt 1356661 gatgatgccc agctgtttac cgattatgac catgtcataa tgggaaccta cacgtgggga 1356721 gacggagatc tgcctgatga atttttagat cttgttgaag acatggagga gattgatttt 1356781 tccggcaaaa catgcgctgt attcggttcc ggtgatacag catatgaatt tttctgcgga 1356841 gcggttgata cgctagaggc aaaaataaaa gaacgcggtg gagacattgt gctgccttcg 1356901 gtaaaaatcg aaaataatcc agaaggtgaa gaagaggaag aattaataaa cttcgggaga 1356961 caattcgcaa agaaaagcgg gtgcgctgtc tgatcactca ctgggaactg ctaaaacggc 1357021 tgttcctttt tttcttgtct ttgtatcttt cctttgatac agtaatgagg tagaaaatca 1357081 ggaggaggac tatacatatg aaaatgatgg acgcaaatga aattatttca tttattcaaa 1357141 atagtacaaa atctacacct gtaaaggttt acgtgaaagg tgagctggaa ggaatcaatt 1357201 tcggtgaatc tgcgaaagct tttatcaatg gaaacactgg tgtcgttttc ggtgaatgga 1357261 gcgaaatcca aacagcaatc gaagaaaacc aaagcaaaat cgaagactat gtggttgaaa 1357321 atgaccgccg caattctgcg atcccaatgc ttgatcttaa aaacatcaaa gcgcgtatcg 1357381 agccgggtgc gatcatccgc gaccaagttg aaatcggtga taacgcagtc atcatgatgg 1357441 gtgcttctat taatatcggt tcagtcatcg gcgaaggcac aatgattgat atgaacgttg 1357501 tgcttggcgg acgagctact gttggaaaaa actgccatat cggcgcgggt tctgtacttg 1357561 cgggcgttat tgagccgcca tccgctaaac cggttgtgat tgaagacgac gtcgtaatcg 1357621 gcgcaaatgc tgttgtgctt gaaggtgtaa cagtaggtaa aggagctgtt gttgctgcgg 1357681 gagcgatcgt ggtaaacgac gttgagccat acactgtcgt tgcaggcaca ccagctaaaa 1357741 aaatcaaaga cattgatgaa aaaacaaaag gcaaaactga aatcaagcag gaattacgcc 1357801 agctgtaagg aaaagtttga taaaaaaggc gtggataata tatccacgcc ttattcgtat 1357861 aggcaggagg aatagaaatg aagatagagg agctcatcgc aattcgcaga gatctgcatc 1357921 gtataccgga gcttggattt caggagttca aaacccagca gtatttatta aatgtcttgg 1357981 aacaatatcc gcaagacaga attgaaattg agaaatggcg aacagggctt tttgtaaaag 1358041 tgaacgggac ggcgccggaa aaaatgctgg catacagagc ggatatcgat gcgctttcta 1358101 tagaagagca aactggtctt ccattcgcat cagagcatca cggcaacatg cacgcctgcg 1358161 gtcacgattt gcatatgaca attgcactcg gcattattga tcattttgtt caccacccag 1358221 tcaaacatga tttgcttttt ctgtttcagc cggcagagga agggcctggc ggtgcggaac 1358281 caatgcttga gagcgatgta ttaaaaaaat ggcagcctga tttcatcact gcccttcata 1358341 ttgctccaga gcttccggta ggcaccattg cgacaaaaag cggccttcta tttgcgaata 1358401 catcagagct agtcatcgat ctggaaggca aagggggaca tgcggcatat ccgcatttgg 1358461 ctgaggatat ggttgtagca gcaagtacac ttgtcaccca gctgcaaacg attatctcta 1358521 gaaacacaga tccgctagac agtgctgtta ttacagttgg taccattacc ggaggctcgg 1358581 cacaaaatat cattgcagaa acggcccacc tggaaggcac gatccgcacg ctttctgaag 1358641 aatcgatgaa acaagtaaag gaacggattg aagatgtagt gaaaggaatc gaaatcggat 1358701 tccgctgcaa aggaaaagtg acatatccgt ctgtatatca ccaagtttac aatacgagcg 1358761 gattaacaga agaatttatg tcttttgttg ctgaacatca actggcgaca gtaattgaag 1358821 caaaagaagc aatgactgga gaggattttg gctatatgct gaaaaaatat cccggattca 1358881 tgttctggct cggcgctgat tctgaacatg ggcttcatca tgctaagctg aatcccgatg 1358941 aaaatgcgat agaaacagcg gttcatgtca tgacaggtta tttttctgtt tatgccaatt 1359001 aagtacaaat gaaagaataa aattccataa aatgagcact ctagtaaacg gaggtgttca 1359061 aaaatggcta aaaaaattgg aattgaacaa tcgttatcag atgtagaagc tgctttaaaa 1359121 gaaaaaggat atgacgttgt aatgatgaaa agccctgctg atgctcaagg ctgtgactgc 1359181 tgtgtcgtaa caggtcttga taataatgtg caagggatag ccgatacggt aacacaagca 1359241 cctgtcatta cagcttccgg gatgacggct gaagaaattt gtagcgaagt tgagagcaga 1359301 attcagtaat aaaaaaaccg aagcaaaaag cttcggttct tttatttatt ctgtttcttt 1359361 agggaaagcg cggtcgaacg cgttctttat ttcttttctc aacactcgtt cgactcgcca 1359421 ctgttccata ttttctgttt tggcaatgac cctgattaca atttcagaag tccccagttc 1359481 ttgaatcccg atgacatttg ggccttcttt tatttgtgga agagccgctg ccgtttcatc 1359541 acaaacctgc tgtaaaatat gaatcatttc atcaatattt ctttcagccg gcactttaat 1359601 gtcaacaaga gcctgcatgg taccacgaga atgattgctc acgtttgtga tgtttctgtt 1359661 ggggatgtaa tgcagtgttc cgtcaaagct gcggatttga gttgtcctta agccaacctg 1359721 ctcgacaatt ccgtcaaagg tggaaacggt aatataatct ccgacatcca attgtttctc 1359781 aagcaaaata aaaaaacctg tcacgatatc actgacaagc ccttgggcgc caaatccgac 1359841 agccaggccg acgattcctg cccccgctaa aagagcgctt ggatcataat gaaacaaatc 1359901 tagaaccatg acgaaaaata tgaaaatcaa tgtataagca aatatgttaa gagtcaggct 1359961 tcggagcgta tgtgcacgtc cgatagacaa gctattctgc tcctcgaatt ttgcaaacag 1360021 atgtttaatg attttcatgc ctaatgatcg aacgataaaa tagagcaata tcataatggc 1360081 gagtttaatg agcagaacac cggcatttgt aatcagtccc gcccaatcat attgtttaat 1360141 aaagtccatg ttgagctcct tttctaattg attgctgcac attgagacta gttaccctgt 1360201 acatgaccat gttaaacgtt ttattcaaaa atgtcgaagc caaagacata catgatttgt 1360261 taaaaattga ctcaggaaat ctgcttttat ataatggcat tgcaatataa ctaaaaatgg 1360321 ttaatcaccc tttattttca tgcgattttg acctttaagc caaacaataa attggaggga 1360381 tacatatggc agaacgtatg gtaggtaaac aagctcctcg ttttgaaatg gaagcagtcc 1360441 ttgcaagcaa agaattcggc aaagtaagtc ttgaggaaaa catgaaaaac gacaaatgga 1360501 cagtgctgtt cttctatcca atggacttca cttttgtttg tccgacagaa attacagcaa 1360561 tgtctgaccg ctatgacgag ttcgaagatc ttgatgcaga agtcatcggg gtttcaactg 1360621 ataccatcca tactcattta gcttggatca atacagaccg caaagaaaac ggtcttggcc 1360681 agctgaaata cccgcttgct gctgatacaa accatgaggt atcccgggaa tatggcgttt 1360741 taatcgaaga agaaggtgtg gctttgcgcg gattgtttat tattaatcct gaaggggagc 1360801 ttcaatatca aactgttttc cataacaaca ttgggcgtga tgttgatgaa acgcttcgtg 1360861 ttctccaggc gctgcaaact ggcggactct gtccggctaa ctggaaacca ggccaaaaaa 1360921 cactttaatt ctttccaaga acgaaaagcg gtctagcata ttcgttaggc ctctctttta 1360981 aaataggagg gaaaaagcaa tgaaattacg tcagcccatg ccggaattga cgggagaaaa 1361041 agcttggtta aatggtgaag tgacgagaga gcaattgatt ggggaaaagc cgacgcttat 1361101 tcatttctgg tccatcagct gccacttgtg caaagaagcg atgccgcaag tgaatgaatt 1361161 tcgtgataaa tatcaagatc agctgaatgt tgtagctgta cacatgcccc gttccgaaga 1361221 tgatcttgac cctggtaaaa ttaaagaaac agctgctgaa cacgatatca ctcagccgat 1361281 ttttgttgac agtgaccatg ctttaaccga tgcatttgaa aatgaatatg tacctgcata 1361341 ttatgtgttt gataaaacag gacagctccg tcacttccaa gccggcggga gcggtatgaa 1361401 aatgcttgaa aaacgtgtga accgcgttct ggctgaaacg gaataggtat ctgactaaat 1361461 agtatttcct aaaaacctga cctcatcagg ttttttattt gtgcaaaaag caatggaaga 1361521 agagtaagaa gcttattttt ccaaatttgg gtataggaat tgatgatttg tttgattgat 1361581 acgctaaaaa acacagctaa tttttgatgt ttttcctcaa ttttagataa atctcatatc 1361641 tcataactcg aaaattgtag atattacact aaatttcttt aaagaagtaa gtaaaatata 1361701 tattttcaac attataccaa ataaactaga aagcccctta atcccttgag aataaaggac 1361761 tcttttgaaa aataaaacat tttcagaaaa taaggaattt ttcatagagt aaatataata 1361821 gtaaaatgct aaaataatag ttgataaaat tacttttgta atctaatatc ttaattaaag 1361881 atgttaattt tgataggggg tacattgagg aatgtttaat gaaagagaag ctttgcgctt 1361941 gcggttagaa caattaaatg aagctgaagt gaaagtcatt cgtgaatatc aaattgaacg 1362001 tgataaaata tacgcaaaat taagagagct ggacagaaat ggaagccctt ccgaaatcaa 1362061 aaaggatttc cgttctgaaa aaaaacctga ctctctgccg gttctcgctg agcttgcggc 1362121 tcaggaaatc agaagctatc agccgcaatc acagcagcag tctgttcagc ctcagcttca 1362181 atctatttcc tctcttcctg ccggtatacc agacggaaca acacgaagaa gaagaggaac 1362241 ggcaagaccg ggatcaaaag cagctaagct gcgtgaagct gctattaaaa cattaaaacg 1362301 ccacaacgcg gcgattaaga gctcggagct tcaaaaagag attgaaaaag aaagcggtct 1362361 tgaaatccct aatatgacaa cgtttatgca aagcttaatt aaaatgtacc cggaagtgaa 1362421 aaagccatat cgcgggcagt acattttaga gggtgaaatc gaatctgcag aatcagcaaa 1362481 cgaataaata taaagaaaaa ctgcttggca tcgctcaagc agttttttta ttgaggtttt 1362541 ttctgtgaag gtttgttttc tttttcaaga ttaagcttat acacccactt ttgataaggc 1362601 ttttcttcag cggctctgtt tttcagctct tcgattgtat ggctcttggc ctggtctgat 1362661 gattgggcgt gggcaagctg tttttgaagc acatgtatct gtttggtgac atcttcaagg 1362721 atagtctcta catgatttgg ctgcgcgtag gccgctggag cttcttcttc cgttttttct 1362781 ttttgtttcg tgccgccatc aatatcggca aaatgagaag caatccaggc atcgctttca 1362841 tcaagttgcc gtttatacga tataatagtt tcgtgaaata atttttcttt cgttttttct 1362901 atgtctagca gtctttcttt cgtttctatg attcgatctt tcatatgatc aacttctatt 1362961 ttaatatgtt ttagctgata ttctttttct accatttgct cttttagacg cccgttttcg 1363021 gcttttatca attcggcttg ctgttttgcc tgaagcagtg cattttgttc ctgctcaatt 1363081 gaggcttgaa gttcgctgat ccgtttatga agatttttat tttcttcttc gattttgact 1363141 ttcgcaatat gaagtttatg tttttcttcg atttcggctc tgcgtttata ggtttcagca 1363201 gatagaagct cctgcaaaac aacgatttta tcaagcagtt cagctcttat ttggtgcagg 1363261 gtttggctgg tgtgggaggc atgtttttct tttgttgaca tatgtgttaa ttcggcagac 1363321 agctgctgga gtttttcttt catatcggta ttttctttga gcagtttgtt atttttctga 1363381 tgaaagtagc ttgcttcaag ttcagaaatc agcttatggc accttgaaag ctcggatttt 1363441 aaataaaggt tctcctgaga cacgtcgtgg aaaaaaggac ctgatctttt cattcgaacc 1363501 atctccctca tgatgttaac actacaatat gcaaatactg aacagctatt cctctttaat 1363561 aaacagacaa gcagtagcgt tgagcctttg cttttgctat gcttttaacg aaactagagg 1363621 tgagatgata tgaagcatgt aaacgtactg ctggcagggg gagcctcacg tcgctttgga 1363681 gaaccgaagg cgtttgtcaa atggaagggc aggatgcttt acgaatgcgc taaagaggca 1363741 cttggagaac aaacggttat catcagccgt cccgaattta ttgatagatt tcaagaaaac 1363801 ggtgaaaatg aagtgtatca agatgctgag ccatttcaag gcatggggcc attggctggt 1363861 atatataccg cttttaaaaa gacagacggt gatctttata ctgttctttc ctgtgacaca 1363921 ccgctgatac aaagaaggac gatgctggag ctcaaacgtc tgatgattgc cggtgcggac 1363981 gcggtagtcc caatttcaga cggacaagtg cagccattga ttgcgattta ccacaaacgt 1364041 atcatgccag ttctatacga tcagctttct gagaagaggt tgagaatatc agatttatta 1364101 ggcagaattt cggtttgtta cgtacaggct gaaaatatcg gagcaaaccc ggcagagttt 1364161 atcaacatta atacacgtga tgattttagc tgtttggaag aaaaatcgaa ctccctcaag 1364221 cgggactgac ggggcaataa catgataaga tgacataaaa gataaggaga acaggtttga 1364281 tggaggaacg ttattcacgg caaatcagat ttaagcaaat tggggaagag ggccagaaaa 1364341 gactggcaga cagccatgtg ctgattgtcg gagcgggagc gctcggcact gcaggagctg 1364401 aagggctttc gagagcggga gtcggtacga ttaccattat tgaccgtgac tatgtggagt 1364461 ggagcaatct tcaaaggcag cagctttata cagaaagcga tgccaaactc cgcatgccga 1364521 aagccatggc tgccaaagag catctatcag cgattaacag cgagatacat attgaggcgt 1364581 atgttaccga aggaacagcc gaaacgcttg agccgctgat tgaaaaagca gatgtcgtga 1364641 tcgacgcgac agataatttt gaaacccgca tgctgataaa cgatcttgcc cagaaaacaa 1364701 agacaccttg ggtctatggc gcctgtgtaa gcagccaggg aatgttcatg actgtcattc 1364761 ccggagaaac cccttgtctg tcttgtttgt ttgagcaaat tcctgtcggc ggggcgacgt 1364821 gtgatactgc cggcattatt ccgcctgctg tgcatatcgt ttcagcatat cagcaggctg 1364881 aggcattaaa gctgttaacc ggccaaaaag aagcaataca gcgggggttt gtgacatttg 1364941 atgtctggaa caattcgcat atgaagatta acgttaatca tgtacgccgt gaggaatgcc 1365001 catcttgcgg agctaatgcg gtatatcctt atcttcagga ttggaacaca ccaaaagctg 1365061 ctgtactatg cggccgtgat acagtgcagg taaggtcaga atcattaaaa agaatcccga 1365121 aacaggagct cattaagcgg ctgaaaacaa tcggcaaggt cgaggctaat gcgtttttgc 1365181 tgcatatttt ttacgaggat ttcagaattg tcattttcaa tgacggacgg gcactggtgc 1365241 atggaacaaa tgatgtgaaa gaagccaact ccgtgttggc aagagtgatt ggactgtaac 1365301 aacaggaggg gtcagaatgc tggagaaaag aacaccgata ccggtagacg aggcagttcg 1365361 gcgtgtctgc cattttcaaa aacaaggtga aacagaatgg gtggcgcttg aagacagcct 1365421 tcatcggttt ttagccgaag atataactgc ggatcaccac gtacctgcgt ttgaccgttc 1365481 gccatacgat ggttttgctg tcagagcgtg cgatacggca gaagcttcac gtgaaaaccc 1365541 agttcggttt gaagttattg accatattgg agcgggagca gtatctgaaa aagaacttgg 1365601 cccgtttcag gccgtgcgga ttatgactgg cgcgcaaatc cctgaagggg cagatgcagt 1365661 cgtcatgatt gaactgactc aagcctttga ggagaatggg aagtcattta tgtctttaaa 1365721 acgccgcttt cagacggggg ataatatttc aaaaacaggt gaggacgctc aaaaagggag 1365781 tgttttactg acaaagggca cccgggtgac accaggagtg acggctcttt tggcaacatt 1365841 cggatacgca tctgtgcctg tcgtgagaaa gcctgtagtc gggattatcg caaccggtac 1365901 cgaattgctg aatgtcagtg atccgctgga accgggaaaa atccgcaaca gcaatgcgag 1365961 tatggtatat gcgcaagcga tagaagcagg cgcaacaccg ctttatttag ggaaaatctc 1366021 tgatgaactg gataaaagct ttgctgcagt taaagaagcg atgaaaaagg tggacttcct 1366081 gatcacaact ggcggtgtgt cagtcggtga ctttgacttt ttgcctgcga tctatgaaaa 1366141 actcggagcg gacgtgctgt ttaataaagt tgccatgcgc ccgggcagcg tgacaacggt 1366201 ggcgcatgca aacgatatgc tgctgtttgg cctttcaggt aatccgtcgg catgctatgt 1366261 cggttttgaa ctgtttgtca aaccgataat ccagacatgg ctgctcaatg aaacaccgca 1366321 ttcaatttgt gcggaagctg ttttgaccaa ggattttccg aagccgaacc catttacccg 1366381 atttgttcgt gcgctcgtgc accatcagga agggaagctg ttggcgacac ccgttggctt 1366441 agataagtcg agctctgtca catcacttgc agatgccaat gcatttatta tcctgccggg 1366501 cggtacgcga ggctacgaat ctggcagaac ggttcaagtg ctgctcatca gagaagagaa 1366561 tggaagtgaa tggccttggt ccgtcctttc ccgatcgtcc aagttgtagg atttcaaaac 1366621 agcgggaaaa caacgtttat tgagcgcatt cttgaaaaag cctctgaaca gggagtccat 1366681 ttgggctgcc tgaagcacca tggtcacggc ggtgaaccgc aaacgctcac ggaaggaaaa 1366741 gacacggacc gttacaaggc ggcaggtgct gatgtaacag cggtagaagg tgctggtgtg 1366801 ttacagctga ctgcccgccg caattgggat ttggcacggc tgattgagtt ataccaattt 1366861 ctcgaaacag actgtcttct gattgaaggc tttaaaaaag ccccttatcc taaagtggtt 1366921 atcctaagtg aaaaggaaga tctggaagcg ctgcaagcag taaatataat cgccatcatc 1366981 tatagaaaaa aagagcatat gacagagcat cagggattac ccgtttttca tgcggatgat 1367041 ccggttgccg tggattttgt gctttcacag ctgaaggggg aatctgcata atggaacggt 1367101 ttgagattac gaaaacaccc attaatactg aaaacatcat caaaaaagtg gagaaacggg 1367161 aagcgggagc cattacaaca tttattggta cggttcggga atggacaaac ggaaaaagaa 1367221 cggttcggct tgaatatgag gcatatgaac cgatggccgt gcaaatgctt gctcaaatcg 1367281 gcgctgaaat cgaagaaaaa tgggaaggtg cctcagctgc gatcacgcac cgtataggtg 1367341 tgctcgatat cggtgaagca gcggtagtga ttgctgtatc ttctccccat cgaaaagccg 1367401 catatgaagc caatgagtat gcgattgaac gcattaaaca gattgtgccg atttggaaaa 1367461 aagaaatttg ggaagacggt gagcaatgga tcggcgacca gctagaaacg acagcttatc 1367521 cgaacggaaa accagaccta agcgagggag agcagcatga ttaaaattct tttatttgca 1367581 gggcttgctg aacaggccgg tacacaagca atagaaatag atatggaaca agcaaccaca 1367641 gatgaaataa aagcgagtct aaaagaacaa tacggtcttg aatctattga tacggctatg 1367701 attgccgtta acgaaagcta tgtaaaagaa aatacctctg tatcttcggg tgacacggta 1367761 gccatcatac cgccggtcag cgggggatga aaaccggacg gcatttcagc cgtccggttt 1367821 ttctgtattt cattggcata tccccaagta tcctcagcat acaatgattt tctgtaagcg 1367881 tttattctac atatgttact ccctataaag taagagactc actccataat tagactgaaa 1367941 ttttgaaaaa taatagaaat ttatttcggg tatcgatata gtgaagatga taaatgttgg 1368001 aaaggtgctg gatatggaga catttaaaag attaaaaatg tattattggc cgtacagaaa 1368061 agtgtttatg tggtcgcttc tagccatgct tttgatgact gcaattactg tcgtttatcc 1368121 gattatcctg caaattacga ttgatgagat cgtactggga cggcagtatc agcttgcggc 1368181 gtgggtcagc ttaggattta ttgcggtgat ggttttgaaa ggaatggcta ccttttttca 1368241 tcagtattta ggtgatatgt tcgggatcaa atccgtttat cggctgagaa atggtctgta 1368301 tgaaaaactg cagcggcttt ctttttctta ctatgataac gcgaaaacag gagatttgat 1368361 gtccaggctg actgctgatg ttgaagggct tcgttttttc ttatcatacg gtctcgctga 1368421 gctcattcgc ttcggcctgc tggtagccat cagcctgtcg gttatgtttt actattctgt 1368481 tcctctcacg cttgtgacaa tagctgttct gccatttctc gcggttgcgg tataccggtt 1368541 tgacaaaaga gtccatcccg ccttcagagg catccgcaaa tcgtttgcga aactcaatac 1368601 aaaagttcag gaaaatatca gcggcattaa tacggttaaa tctctttcca gggaagattt 1368661 tcagatcagc actttcaata aagccaatgc agaatacagg gcgcagtatt tacaaacatc 1368721 atccatttgg tctgcgtatt tccctttaat ggagttcatt ggtaacactt gtattgtagc 1368781 tcttctctca tacggcggtt acttggttat gcaaaatcag ctcaatcccg gcgagcttgt 1368841 tgctttcttc agccttgtca attatatgat gtggcccatt atgaacttag gttttgtcat 1368901 caatatgttc tctcaagcaa aagcgtcagg ggaacgcctg ctcgacattc tggaaaaaga 1368961 agaagacatt acagatcatc ctcatgcttt gcataaacaa aaattaaccg gagatgtcca 1369021 tttcaaaaat gtttctcttg catacggaaa agaacaaaca aacgcgctgt gcaatgtaag 1369081 ctttgaggca aacagcggga aggtaatcgg actgttgggc ccgacaggtt caggcaaaag 1369141 ctcagtgaca cagcttctca ccagatttta cagtcctgtt ggcggaatga ttaccattga 1369201 tcacaaaccc atcacagatt attcgttaaa aacccttcgc tccaatatcg gggtcgtact 1369261 tcaagaatcc ttcctgtttt catctacgat tagatcaaat atttcgtatg ggcggccgga 1369321 tgcctcaatg gaagacgtca tcgaagcggc aaaaagggcg caggctcata actttattat 1369381 ggagcttcct gatgggtatg acaccatgct gggagagagg ggaatggggc tttccggcgg 1369441 gcagaaacag cgtattgcca ttgcgagagc catctgcttg aacccgagca ttttaatatt 1369501 ggatgatgcc acaagcgcag tagatatgca aacggagcac agcatacagc ttgccttaaa 1369561 agaagtcatg aaaaaccgca caacctttat cgtcgctcac cgcatttctt cactgaaaca 1369621 cgctgatgaa attctcgttt ttaataaagg acgcattcgt gaaaggggaa cacatcatga 1369681 gcttcttgaa aaaggcggct actataaaaa gatttacgat ttgcaatacc gtgatgtcaa 1369741 aatgattaat gagccgcatg aggtcggata gggaggggcc aaatgaaaca agcgaaaaaa 1369801 cagggggttt tagagcgttt ctattactct tcagatgaaa tcattgaaaa gccgtttaac 1369861 tgggctcaaa tgtggcggct gctgagctat gtcaaaccat atcgaaaaac aattttgccg 1369921 ctttcttttc tcactgtatt gattggcact gctgtgaagc ttgtgatccc cattttgatc 1369981 ggcgtttatg ttcttgatca agcgattaca gggagaaact cggagctgct gattcagctc 1370041 atttttatta ttagcggttt atatgtcctc aattacgccg ccaatgtgtt aagaatcagg 1370101 tggatgaatc agcttggcca gcatgtcatt tacgatttgc gacagcattt atttacccat 1370161 gtgcagcgct tatcccatcg attttttgat cagcggtcgg cgggatcgat cttagtcagg 1370221 atcatgaatg atattaactc tcttcaggag ctctttacaa gcggagtcat caatttgttg 1370281 accgacttgc tgcttctggc cggcgtgatt attattttgt ttacgctgag ccctgagctg 1370341 actatagcca tcatggtgac attgccgatt atgtttttta tttcaacaag tctcagaaaa 1370401 aaaatacgcc gatcctggca aacggtacgg ctgaagcaat cgaagctcaa ctctcatcta 1370461 aacgaaagca ttcagggcat ccgggtcacg caggcattta cgcaggaaga agaaaacatg 1370521 gcgtattttg acggtgtcaa tcaggagaac tacgaatcat ggcgggaagc aactagaaaa 1370581 aatgccatgt tccgtccgct tgtagaaatg acgaatgcga ttgggacggc tgtcttgatt 1370641 tggtatggag ccacactcat catgaatgaa accattacga ttggcgtctt cgtttctttt 1370701 gctttctatc tgggaatgtt ttgggaacct atttcgagac tgggtcaggt ctataatcag 1370761 ctgttaatgg ggatggcatc atcagaacgg atttttgagt ttctggacga acagccaaat 1370821 gtcaaggaga agccgaatgc cattcataat gaaaagataa atggggagat cagttttgaa 1370881 gaggttgaat tttcgtatga tgaaaaacga aaagcccttc acgccgtttc tttctctatt 1370941 cctgcgggat cgacgcttgc gcttgtcggg catacaggga gcgggaagac gacgattgcc 1371001 aatttaatca gccgttttta tgatgcggcc ggaggcacca ttaaaataga cggtataccg 1371061 attaaggatc tttcccttgc cagtctgcgc tctcaaatca gcattgtcct gcaagataca 1371121 tttattttct ccgggaccat catggaaaat attcgttttg gaaggccaaa tgcttcggat 1371181 gaagaggtga tgaaagcgtc ccaagcggtc ggagcggatg agtttatttc cgatttagcg 1371241 gaaggatacg caacagaggt agaggaaagg ggcagcgtac tgtctgccgg tcagcgccag 1371301 ctcatttcat ttgcaagagc attgctcgcc gatccggcta ttatcatcct tgacgaagca 1371361 acggcaagca ttgatacaga gacagaagta aaaattcagc aagcgttaaa aacgcttctg 1371421 aaagggcgta cagcagtgat gatcgctcac agattgtcta cgatccgcga cgccgaccgc 1371481 atcattgttc ttgatcacgg caggaaaata gaagaaggga accatgatca gctgctcgct 1371541 aaaggaggca tttatgccgg gcttgtgaaa gcgcaataca gcacagcgat agaataatat 1371601 gaaaagcctt caatattgaa ggtttttgga aatttattag aaaaacatga aactttttga 1371661 tatccttccc gtactatttg ttagatattc tcaaggaggt tttgaaatgg aaacgaatgt 1371721 agaaaaaaac agcggaacgg cgactgaaaa gccttcactt ttcggagtaa tcacaagtcc 1371781 gtccgttcaa tttgaaagaa taagagaaag gccggctgta tggggaccgc ttttgattgt 1371841 tgcagcaatt atcatcgtcg gtgccgtgct gcaatcactc ggtacggatt atagtgagct 1371901 tttgaaaagc caggatacgc aagggctatc tgctgaacaa atggaaactg tcgcaacaat 1371961 aaccaaattt ggcggaatgg caggcgctat tatcggcggt atcgcagcat tatttattgc 1372021 ccctcttatt tattggctct gtgtaaaagt atcaggcggt gttacgacat ataaaaaaat 1372081 gctttctctc agtctgtttg tctctttgat tagcagtctc ggattattgg ttaatggaat 1372141 cgttgctttt acgactgacg tgaatcctct ttacagcacg acgtcactcg cagggattat 1372201 cccatctgac ggggctctcg ccagtgtgtt aaataccttt gaaattttca gcatctggag 1372261 ctttgtatta ttagcaatcg gacttcacaa aacgggaggc atctcaaaaa aagccgggtg 1372321 gatttcagca atcattctat tcggaatttt agttgtattt tcgctttttt caggtttaat 1372381 caattctgtg gcgggtgcat aagctcatga aaaaagtctg gatcggaatt ggaatcgcag 1372441 ttatagtcgc tctttttgtt ggaatcaata tataccggtc tgccgctccg acaagcggca 1372501 gcgccggcaa ggaggtacag acggggagcg ttgaagaaaa tgaaatctca tcaacggtta 1372561 tggttcctgg cacgctaaaa ttttcaaatg aacagtatgt cttttatgaa gcggataaag 1372621 ggacattaga agacattaaa gtaaaggaag gcgataaagt taaaaagggc acggctttag 1372681 tcacctatac aaatgagcag ctgagcctgg aaaaagaaca gaaccagtta acgtctgaat 1372741 ccaaccggct tcaaattgac caaattcaag aaaagttaaa agccttggac agcaaagaaa 1372801 gagaactgga aaaacaggta ggaaagaaag aagcagaaaa acaaatcgaa tctgaacgga 1372861 cagagcttca aatgcagaaa aaaacagcgg agatcgaatt aaaacaaacc gagcttcagc 1372921 ggcagtcact tgccaaccgg gtgtcagatt tagaagtgaa aagcgaaatt gaaggcaccg 1372981 ttatttctgt caaccaagaa gcggcatcca aaaagtcaga tattcaagag cctgtcatac 1373041 atatcggcaa cccaaaagac cttgtcgtct cagggaaatt gtctgaatac gatacattga 1373101 aagtcaaaaa aggccagaag gtcacactca cttcagatgt aatacagggt aaaacatgga 1373161 aaggcacggt ttccgcagtc gggcttgttc cggatcagca ggagagcgct gcggcacaag 1373221 gaacagaaca ggcggtccaa tacccgcttc aagtgaaaat aaaaggaaat cttccagaag 1373281 gaaagccagg ctttaaattt atcatgaata ttgaaacaga taaacggaaa gcaaatacgc 1373341 ttccttcaaa ggcagtcaaa aaagaagatg accaatatta tgtgtataca gtaaaagacg 1373401 gaaaagcaaa gcgagttgat gtcaaaatcg gcgaagtgac agatgacctg acagaaatta 1373461 aagaggggct tacccaagat gatcaagtca ttttgaatcc atctgatcag gtgactgacg 1373521 gaatggaagt gaaatcctaa atgattcagc tttctaatgt gcgaaaaagc taccagatcg 1373581 gaaaggaaac gtttgatgtt ctccattcta ttgatttgga cattcatcaa ggtgaatatg 1373641 tctcgattat ggggccgtca ggatcaggaa aatcgacgat catgaatatt atcggctgtc 1373701 ttgatcggcc gacttccggt acatatcaat tggacggcga agacatttct tcatataaag 1373761 ataaagaact ggcggcagtc cgtaaccggt ccatcggttt tgtatttcag caatttcagc 1373821 ttcttccgcg gctgaacgca aaaaaaaatg tcgagctgcc gatgatttat tccgggatag 1373881 gcaaaaagga acgtcaagag cgggctgaga gagcattgga aaaggtcggg ttagccgatc 1373941 gaatgctcca catgcccaac gagctgtcgg gcgggcagaa gcagcgggtg gcgattgcga 1374001 gggcgatcgt gaatgagccg aaattgattt tagctgatga accgaccggc gcgctggata 1374061 cgaaaacaag cgaggcgatt atggatcagt ttacagcatt aaatgccgag ggaacgacaa 1374121 tcgttctggt tactcacgag cctgaagtag cagattgcac gaatcggatc gtcatggtgc 1374181 gtgacggaaa cattgttcct gccagctccg gacaaaggag tgtgggagaa tgagcctgtt 1374241 ggaaaacatc agaatggctc taagctctgt ccttgcccat aaaatgcgtt cgatcttaac 1374301 gatgctcggc attatcattg gtgtaggctc tgtcattgtt gtcgttgcgg taggacaggg 1374361 cggcgagcaa atgctgaagc agtcgatcag cggcccggga aatactgtgg agctgtacta 1374421 tatgcctagc gacgaggagc ttgcaagcaa cccgaatgcc gcagctgaat ctacgtttac 1374481 agaaaacgat attaaaggtt taaaaggaat agaaggcatt aaacaagtcg ttgcttcgac 1374541 ttctgaaagt atgaaagcgc gttatcacga agaagaaacc gatgctacgg ttaacggaat 1374601 aaatgatgga tacatgaatg tcaattcttt gaaaatcgaa agcggcagaa cctttaccga 1374661 caatgacttt ctcgcgggga atagagtcgg aatcatctct caaaaaatgg ctaaagagct 1374721 gtttgataaa acctcccctc taggtgaagt tgtctggatt aacggacagc ccgttgaaat 1374781 tatcggcgtg ctgaaaaaag taacaggctt gctttctttc gatttaagtg aaatgtatgt 1374841 gccatttaat atgatgaaat cctcttttgg cacaagtgat ttcagtaacg tatcattgca 1374901 ggtcgaatca gcagacgaca taaaatcggc tggaaaagaa gcggcacagc tggtaaatga 1374961 caatcatggc acagaggatt cgtatcaagt gatgaacatg gaagagattg cggccggaat 1375021 tggcaaagta actgcaatta tgacgacgat tatcggctca attgcaggta tttccctttt 1375081 ggtcggcgga atcggtgtca tgaatattat gctcgtatca gtcacagaac ggacgcggga 1375141 aatcggaatc agaaaatcac ttggtgcgac gaggggacag attctgactc agtttttaat 1375201 tgaatcagtc gtattgacgc tgattggcgg tctggtcggg attggtattg gatacggagg 1375261 ggccgcgctt gtttcagcca ttgcgggctg gccgtcactc atatcctggc aggttgtatg 1375321 cgggggcgtg ctgttcagta tgctcattgg tgttattttc ggcatgcttc ctgcaaataa 1375381 agccgcaaag cttgatccca ttgaagcgct gcgttatgag tagcctcatg caacatgcat 1375441 gaggtttttt tatgtttagt gatttctact atgaatataa aagacttttt tcattaaaat 1375501 aagaagaaaa tgtcgtacaa ttgtccttat ttttgtcgaa tttacagttt acaaacccta 1375561 tagacatacg ttaatatgga gaaacgtgaa agattttgat agttattgaa tgaatttgaa 1375621 tgattttagt tgcctaaacc gaaaatagcg tttacaatga aattgtattc aaaatgaata 1375681 cgttttcatt aggaggtgaa gcatgctaac tcctgaacgg catcaattga ttattgatca 1375741 aatagaaaag catgatgtgg taaagattca agagcttata aatctgacta atgcttctga 1375801 atcaacaatc agaagagatt tatcgaccct tgaagaacgc ggttttttaa agcgcgttca 1375861 tggtggagcg gccaagcttt ccgatatcag acttgaaccc gatatgcttg aaaaatcatc 1375921 caaaaacctt cacgataaac tgaagattgc tgaaaaagct gcttctcttt tagaagaagg 1375981 ggattgcatt taccttgatg caggcacgac gacattgcac atgattgatt ttatggataa 1376041 aaccaaagat attgtcgttg tcacaaacgg ggtaatgcat atcgatgcat taataaggaa 1376101 agaaatttct ttttatctgc ttggaggata cgtaaagcac agaacgggcg cgattattgg 1376161 aggcgcttca ttggttgcca tggaccagta cagatttgac aagagttttc tggggacaaa 1376221 cggtgtccat acagaggctg gatttacaac gccggaccct gatgaggccc ttttaaaaca 1376281 gaaagcgatc aaacaggcaa aacacgctta cgtcttagca gacccttcga agttcggaga 1376341 aatttcattt tcggcattcg ccggaatagg cgacgcaaca atcattacga ctgacgctga 1376401 agagcttaca ttcgataatt accaagaaaa aactgtcgta aaggtagtga aaccatgatt 1376461 tacactgtaa cacttaatcc atctgtcgat tatatagttc acgttgaaga ttttactgta 1376521 ggaggcctga accgttcttc gtatgatacc aagtatccag ggggcaaagg catcaacgta 1376581 tcgagactgc tgaaaagaca ccatgtggcg tctaaagcgc tcggattcgt cggcggattt 1376641 accggagaat atatcaaaac atttttacgg gaagaaaacc tggaaacagc tttttctgaa 1376701 gtaaaagggg atacccgtat caatgtaaag ctgaaaacgg gtgatgaaac tgaaattaac 1376761 gggcagggac cgacaatttc ggatgaagat ttcaaagcct ttttagaaca gttccaatct 1376821 ttgcaagagg gagatatcgt tgttcttgca ggaagcattc catcttcact ccctcacgat 1376881 acttatgaaa aaatcgcaga ggcctgcaaa cagcagaacg cacgagttgt tctggatatc 1376941 tcaggcgagg ctcttttgaa agcaacagaa atgaaaccat ttttgatgaa gccaaatcat 1377001 catgagcttg gagaaatgtt cggcacggcc attacatctg ttgaggaagc cgttccttat 1377061 gggaaaaagc ttgtagaaca aggcgctgaa catgtaatcg tatcaatggc cggagacgga 1377121 gcgcttctgt ttacgaacga agctgtttat tttgctaacg tgccaaaggg gaaattggta 1377181 aactcagtcg gagcagggga ttccgttgtt gcaggtttcc ttgccggaat ttccaaacag 1377241 ctgccgcttg aagaagcatt ccgcttagga gttacttcag gcagtgctac cgcgttctct 1377301 gaagaacttg gaacagaaga atttgtccag cagcttcttc ctgaagttaa ggtcacacgt 1377361 ctatagagga ggaaacacaa gtgaaaataa ctgagctttt aacgaagcat acgataaagc 1377421 ttaatattga gagcaaagaa aaagaaaatg ttattgacga aatggtcact gttcttgata 1377481 aggctggaaa gttaaatgac cgacaagcct ataaagaagc cattttaaat cgcgaaagcc 1377541 aaagctccac gggtatcggt gaaggaatcg ctatccccca tgcgaaaacg gcaagcgtta 1377601 tcaacccggc gatcgcgttc ggacgttcaa aagacggcgt cgattatgaa tcattagacg 1377661 gccagccggc tcacttagtg ttcatgatcg cggcgactga aggcgcaaac aacactcacc 1377721 ttgaagcatt gtcaagactt tcaacgctgt taatgcgtga agaaatccgt aagcagctcc 1377781 ttgaagctga gtctgaagat gccatcatcg acattattaa tcagcacgat aaagatgatg 1377841 acgaagagga agaggaagaa gaagcggcac cagcacctgc cggaaaaggg aaaattttag 1377901 cggttactgc atgcccgaca ggtattgccc atacattcat ggctgcggat gcccttaaag 1377961 aaaaagcgaa agagcttggt gtggaaatta aggtcgaaac aaatgggtca agcggcatta 1378021 agcacaagct cactgcccaa gaaatcgaag atgcacctgc aatcattgtc gcagcggaca 1378081 agcaggttga aatggaacgt tttaaaggca agcgcgtact tcaagttcct gtaacggcgg 1378141 gtatcagacg tccgcaagag cttatcgaaa aagcgatgaa tcaagatgcg ccgatttatc 1378201 aaggcagcgg cggcggttca gcagcttcaa atgatgatga agaagcgaaa ggcaagtctg 1378261 gaagcggtat cggaaacacg ttttataagc acctgatgag cggtgtcagc aacatgcttc 1378321 cgttcgtagt cggcggcggt attctcgttg cgatttcatt cttctgggga attcactctg 1378381 ctgatccgaa tgatcctagc tacaacacgt ttgcagcagc attaaacttt atcggcggcg 1378441 acaatgcatt aaaactcatt gttgcagttc tggccggttt cattgcgatg agtattgcag 1378501 atcgtcctgg ttttgcgcct ggtatggtcg gcggatttat ggcaactcaa gcgaatgctg 1378561 gattcttagg cggcttaatt gccggattcc ttgccggtta tgtcgtgatt ttactgaaaa 1378621 aagtatttac gtttatccct cagtcacttg atggattaaa acctgttttg atttacccgc 1378681 tgttcggtat ttttatcact ggcgtattaa tgcaatttgt cgtcaataca cctgtagcgg 1378741 catttatgaa tttcttaaca aactggcttg aaagccttgg tactggaaac cttgtgttaa 1378801 tgggtattat cttgggcggc atgatggcga tcgatatggg cggtccgctt aataaagcag 1378861 cctttacgtt cggtatcgcc atgatcgatg caggcaacta tgcgcctcat gcagcaatca 1378921 tggccggcgg tatggttcct ccgcttggta tcgcacttgc aacaaccatt ttcagaaaca 1378981 aattcactca gcgtgaccgt gaagctggta ttacatgcta tttcatggga gctgctttcg 1379041 taacagaggg agcgatccca tttgctgcgg ctgatccgct tcgcgtcata ccagctgctg 1379101 tagtcggtgc agctgttgcc ggcggattaa ctgaattctt ccgagtaacg cttccggcgc 1379161 ctcatggagg agtattcgta gctttcatta caaaccatcc gatgctttac cttttaagta 1379221 tcgtgatcgg tgctgtcgtg atggcaatta tcctcggtat cgtcaaaaaa cctgttacag 1379281 aaaaataaga aaaaaagcgt ccttggttcg aaaggacgct ttttcttatc cggccggcag 1379341 ggagcgcggt taagttatgt attttattct tttttatgat aaagtaaaag aagagaaaca 1379401 actgacatag caattgtcta ggaggaaaca ctttgaccga ggaaaaaaat acgaatactg 1379461 agaaaacggc gaagaaaaaa accaatacgt acctggaatg gggtaaagcg attgtcatcg 1379521 ctgttctgct ggctctcctg atccgtcact ttttgtttga accgtattta gttgaaggtt 1379581 catctatgta tcccacatta catgacggag aaaggctgtt tgtgaataaa acagtcaact 1379641 atatcggcga gctgaagcgc ggagatatcg ttattatcaa cggtgaaact tctaaaatcc 1379701 attatgtaaa aagattgatc ggaaagcctg gagaaaccgt tcaaatgaag gatgacacgc 1379761 tttatataaa cggtaaaaaa gtagccgagc cttacttgtc taaaaacaag aaggaagcag 1379821 aaaaacttgg tgtcagtctg acaggagact ttggaccggt taaggttccg aaaggcaaat 1379881 actttgtcat gggagataac cggctgaatt ctatggacag ccgaaacggg ctgggactga 1379941 tcgcggaaga tcgaattgtc ggcacatcga agtttgtctt tttcccgttt aacgaaatgc 1380001 gtcaaacaaa ataaaaacgc cttgctggcc taggacagca ggcgttttta ttttgaaaaa 1380061 gaagcgacca atgcaatgca taaaaccgtg atgaacactg aaccgataat agccagcaca 1380121 ctgaagaaaa ggtgaacctg tttgttctct tttccgcgct tttctaatag ccgtttagaa 1380181 aaaatgtgcg aaaatatgta aataagggct atgcctatat ataagccgat atctttggcg 1380241 gtaaagcctg ttacggcaag gtaaaagccc gtaaaaaaga tcagtaagca atattcagta 1380301 agtgttaaaa gcctcaacgt gttcctccat gagagtgtgt aattttccag gcggatgcat 1380361 tctctctctt taattgtaac acagctggct ggtttgggtg tataagtgtt ttctctctgt 1380421 tttatcaggg aatcatttct cttgccctgc attcatggta tacttttatt gatgatagac 1380481 atgatggagg ataataaatg attgctgtaa ataatgtaag cttgcggttt gcggatcgca 1380541 agttatttga agatgttaat attaaattta ccccaggcaa ctgctatggg ttaattggtg 1380601 caaacggtgc cggtaaatca acgtttctaa aggtgctgtc aggcgaaatc gagcctcaga 1380661 caggcgacgt gcatatgagt cctggcgagc gtcttgccgt cttgaagcag aaccattttg 1380721 agtacgaaga gtatgaagtg ctgaaagtgg tcattatggg ccacaaacgc ctgtatgaag 1380781 tcatgcagga gaaagacgct atttacatga agcctgattt ctcagatgag gatgggattc 1380841 gtgctgctga gctagaaggt gaattcgcgg aactgaacgg ttgggaagcg gaaagtgaag 1380901 ctgcgatcct gttaaaaggc cttggtatct cagaagatct gcacacaaaa aagatggcag 1380961 acctcggcgg ttcggagaag gtaaaagttc tcttggcaca ggcattattc ggcaagccgg 1381021 atgttctgct gctcgatgag ccgacgaacc acctggacct tcaggcaatt cagtggcttg 1381081 aagagtttct gattaacttt gaaaacacag ttattgtcgt atcccatgac cgtcactttt 1381141 taaataaagt atgtacgcac attgccgacc ttgattttaa caaaattcaa atctatgtcg 1381201 gaaactatga tttctggtac gagtcaagcc agctggcgtt aaagctttct caagaagcga 1381261 acaagaaaaa agaagagcag attaaacagc ttcaagagtt tgtcgctaga ttcagcgcca 1381321 atgcgtctaa atctaagcag gctacatcaa gaaagaaact tctcgaaaaa atcacgctgg 1381381 atgatattaa accgtcttcc cgccgctatc cttatgttaa cttcacgccg gaacgggaaa 1381441 tcggaaatga tgttcttcgc gtggaaggct taacaaaaac aatcgatggc gtaaaggtgc 1381501 ttgacaatgt cagctttatt atgaatcgag aagataaaat tgctttcact ggccgaaatg 1381561 aacttgctgt tactacgctg tttaaaatca tttccgggga aatggaagct gacagcggaa 1381621 cgtttaaatg gggtgttacc acatctcaag cgtattttcc aaaagacaac agcgaatatt 1381681 tcgaaggcag tgatctgaac cttgtagact ggcttcgcca atattctccg cacgaccaaa 1381741 gtgagagctt tttacgcggt ttcttaggac gcatgctgtt ctctggagaa gaagtccaca 1381801 aaaaagcaaa tgtactttcc gggggagaaa aggtccgctg tatgctgtcg aaagcgatgc 1381861 tttctggcgc caatatttta attttggatg agccgaccaa ccatttagac ctagagtcca 1381921 ttacagcgct caataacggc ttaatcagct ttaaaggcgc tatgctgttt acttcccatg 1381981 accatcagtt tgtgcagacc attgccaaca gaattataga aattacacct aacggcatcg 1382041 tcgataagca aatgagctat gacgagttcc ttgaaaatgc tgatgtgcag aaaaaattga 1382101 ctgaactata cgccgaataa aaaagcagag atttctctgc tttttttgat acctaaatgt 1382161 gaaaggagat cacaacatga aatttttggt tgtcggagca ggtggagtag gcgggtatat 1382221 tggcggacgg ctttcggaga aaggaaatga tgtgacattt ctcgtgcgcc aaaaacgagc 1382281 tgagcagctt aaaaaaaccg ggcttgtcat ccatagtgaa aaagggaatg tatcatttca 1382341 gcccgaacta atcagtgccg gagaaacagg gcaatttgat gtcgttatca ttgcttctaa 1382401 agcatactcg cttggtcaag tgatagagga tgtcaaacca tttatccatc aagaatctgt 1382461 cattatccct tttttaaatg ggtaccgcca ctatgagcag ctatttgcgg cattttcaaa 1382521 agaacaggtg ctgggcggcc tgtgttttat agaaagtgct ttagacaaca aaggagaaat 1382581 tcatcatacg agcgcatcgc atcgttttgt atttggagaa tggaacggcg agcgtacgga 1382641 gcggataaga gcgcttgaag aggcattttc aggtgtgaag gctgaagtca tcattagcgg 1382701 gcatatcgag aaggacattt ggaaaaagta tctctttatt gcagcgcaag cggggatcac 1382761 aacgttattt caacgaccgc ttggcccaat cctcgccaca gaagccggac gtcacacggc 1382821 ccaaactctt attggggaaa tttgcactgt tttacgaaaa gaaggtgttc cggctgatcc 1382881 ggctcttgag gaagagagct ttcgtacgat gaccagcatg tcttaccata tgaagtcctc 1382941 catgcttcgg gatatggaaa acggccaaac gacagaaggc gaccacctgc atggattttt 1383001 gattgaaaaa gcaaaacgtt tatctctcgc tgcaccagta ttagaaaccg tttatgcgaa 1383061 tctgcaaatg tatgaagcag aaaaataaaa aaaggaggcg gaaaagcctc cttttattta 1383121 cttaaaaagc ccaatttccg tttctgaaga taggctctct tttcccgtct gccgtaattc 1383181 cgtcaatatt catatcctta gaaccgatca taaagtccac gtgtgtaatg ctttcattta 1383241 ggccttcttt gacaagctct tcacgagaca tctgctttcc gccttcaata ttaaaggcat 1383301 aggcgcttcc gatcgccaaa tgatttgacg cgttttcatc aaacagcgtg ttatagaaaa 1383361 gaatgtttga ttgtgatata ggcgaatcgt aaggaacaag tgccacttca cctaaatagt 1383421 gagaaccttc atctgtttcc accagttctt ttaaaatatc ctcacctttt tcagctttaa 1383481 tgtcgactat acggccattt tcaaacgtca gggtgaaatt ttcaataata tttccgccgt 1383541 agcttaatgg ttttgtgctt gataccactc cgtcaacccc gtctttttgc ggcagcgtga 1383601 acacttcttc tgtcggcata ttggccataa actcatggcc actttcattc acgcttcccg 1383661 cacctgccca aacatgcttc ctaggcagct taattgttag atcagttcct tctgcttgat 1383721 aatgtaaggc agcgtaatgt ctctcgttca aatggtcaac tttttcatga agattttggt 1383781 catgattgat ccacgcctga accgggttgt cttcatttac gcgcgtcgct ttaaaaattt 1383841 cttcccacag aaggtggatc gcttcctcct ctgatttgcc aggaaacacc ttgtgagccc 1383901 agcctgctga tgccgcacct acgacagtcc agctgacttt gtctgattga atatattgtc 1383961 tgtatgtatg taatgctttg cctgctgctt tttggaatgc cgcaatccgt ttggaatcta 1384021 taccttttag caagtctggg ttcgacgaca caacagaaat gaaagcagct ccatttttgg 1384081 caagctcttc tctgcctttt gcttcccatt caggatattc ttcaaatgct tcaaacggcg 1384141 caagttcgta ttttaatttg gcgacttcgt catcctgcca attcacggtg acgttttttg 1384201 cgcccttttc atatgcgtgt tttacaatta aacggacaaa atcccgaacg tctgttgaag 1384261 catttacgac tacatactgg cctttttgga cattaacgcc gacttctacc gccagctgtg 1384321 catatgtatt taatttctgt gaaaatgaat ccatgaatca ttcctccaag cttttttctc 1384381 atcatatcaa atatgatcct ataaaggaaa gaaggagccc aaagtgaaaa acccaaaacg 1384441 acacgtcttg ggttttttca atattatgga tgattcagtt ttacagtgcc gcctgcaggc 1384501 gaatggggca tatttgccaa agaaatgctc atgcctccaa gaataattcc gcttaaaatg 1384561 gctgcgatcg ctactcttct tcctaaatct cttagcatct gtttcctcct taacgtttct 1384621 ccatttccca caatatgaag gaagtgagga aaaaagaagc aagaaatttg ccgcgtgtga 1384681 gaattttgcg ggtaaagact atttaattgc cttttgcagc ttatcaatca cttctaaaga 1384741 acggcctgtg ccgattgcta cagattcaag cgggttttgc gccacgtgta caggcacgac 1384801 aatctcttct gtgagccatt ctttaattcc attaaggagc gcgccgccgc ctgttaaaat 1384861 aacgccgcga tcaacaatat ctccgctcaa ttcaggcgga cagtcctcaa gtgtcgctct 1384921 gatggcttca agaatatgca ggagggattc acgcattgca tcttgaattt cgttggattg 1384981 aagcataatg gtttttggaa gacctgtcac gaggtcacgt ccccgaattt ccattgcctc 1385041 tggtatatgt tcaatcagag catggccaat ttccattttt acctgctcag ctgtgcgttc 1385101 gccgatcagc aaattgtatt ttttacggac gaaagaaacg atatcctcat caagctggtc 1385161 tccgccgatc ctgatagaat ggcaggaaac aacgccaccg aaggaaataa tagcgacctc 1385221 tgtcgtccct ccgccgatat ctactaccac attggcaacc ggctcatcaa ccggtaaatc 1385281 cgctccgatg gcggctgcaa ctggctcttc gattaaatga acgtttttcg cgccgcaatt 1385341 tttcaccgca tcactgatgg cgcggcgttc tactgctgtt gagcctgatg gtgtgcaaac 1385401 gactacgttc ggttttctga acgacatgcc gatgcttttt gcggcttttt tcataatgtg 1385461 ctttagcagg tcagttgtca tatcatagtc tgcgatcacg ccatctttca tcggtctgac 1385521 agcgacaatt tttcccggtg ttttaccgat catgtttttc gcgtcagctc cgattgcaag 1385581 cactgctttt gtcgtcgtat ccactgcgac aacagatggt tcatttagga taatcccttt 1385641 atttttgctg taaacaagta tattagctgt tcctaagtca atcccgattt cagttgattg 1385701 aaacatgttt tcacccaatc tctatcctaa tttaatatga ttctacattt aaagtttctc 1385761 agaaatactg cgatttttgg gggtgtgcgt cggtaaagaa atgtttttgt aaaaaatcaa 1385821 ggaactgtgt aacagaagta atacattttt cggttttatg gaaaaaatat cttgtaattc 1385881 ttatagaaag cgggaaactt tttcaaagtt tcattcgtct acgatatatt gaggtacatc 1385941 cttaaaacat tacatgagaa aagaaacatt taaaggaaga agggttttta tgaaatcaat 1386001 aggtgttgtg agaaaagtag atgaattagg ccgcattgtc atgccgattg agttgagacg 1386061 ggcattggat attgccataa aagacagcat tgagtttttt gttgacggag ataaaattat 1386121 cttgaaaaag tacaaacctc atggcgtttg tttaatgact ggagaaatca cttcagaaaa 1386181 taaagaatac ggcaacggta aaattacgct aagccctgag ggtgcacagc tgcttctcga 1386241 agaaattcaa gccgctttaa aagaataaaa ttatgctaaa aaaggcggag tgatatcatc 1386301 tccgcctttt ttgcgtgcca atttttgatt accgccgcct aagataagac atcaagatat 1386361 ttggtaatga atgatttggg atactttaca tattttactc aattatttgt cgaagaatgg 1386421 tacaataagt agagaaacac aagcggcagg tggtcatatg agaaaatatc aagctcgtat 1386481 catttccatc attttggcaa tgatttttat aatgttttgg gattatttat tttattttat 1386541 aggcaaaaac ccgattaatt ggcctgttga tattgtgtat actgcagtca cgctggtaag 1386601 tgtctggatg ttggcttatt atattgatga gaaacagcag ctggttaaga aaatgaagga 1386661 taacgaatgg aagtataaac agctttctga agaaaaaaac cgcatcatgg ataatttgca 1386721 ggaaatcgta tttcaaacga atgcaaaagg tgaaattaca tatttaaacc aagcgtgggc 1386781 atctataacc gggttttcaa tcagtgaatg tatgggaaca atgtataacg attacttcat 1386841 aaaagaaaag cacgtagccg accacattaa cacccaaatc caaaacaaag cgtcttctgg 1386901 catgtttacg gcaaaatacg tgacaaaaaa cggcacgatt ttttggggag aagttcatta 1386961 taaactttac tatgaccggg atgaccaatt tacaggcagc ctgggtacaa tgtcagatat 1387021 cactgagcgg aaagaggctg aagatgagct cattgagatt aatgaacggc tggcgaggga 1387081 atcccagaaa ctatcaatca caagtgaact tgccgcaggt attgctcatg aggtcagaaa 1387141 ccctttaaca tctgtcagcg gtttcctcca gattatgaaa acacaatatc cggacagaaa 1387201 agactatttt gacatcatct tttcagagat taaaagaatc gatttagtgc tcagcgagct 1387261 gctgctgctt gcaaaaccgc aggcaatcac atttaaaaca caccagctta atgagatctt 1387321 gaaacaagtc acgacattgc ttgataccaa tgcaattctg tccaatatcg tcatagagaa 1387381 aaatttcaaa gagacagatg gctgtatgat taatggagac gaaaatcagc tgaagcaggt 1387441 ctttatcaac atcattaaaa acggaattga ggcaatgcca aagggcggtg tcgtaaccat 1387501 ttcaactgct aaaaccgcct ctcatgcagt gataagcgta aaggatgaag gaaacggcat 1387561 gccgcaggaa aagctgaagc agattggcaa acctttttat tcaacaaaag aaaagggcac 1387621 tggactggga cttcccattt gtttgagaat cctgaaggaa catgacgggg aattgaaaat 1387681 cgaaagtgaa gctggaaaag gcagcgtctt tcaagtggtt ttgcctttaa aatcagacag 1387741 ctgagaggag aaaaataaag tgaactcgct tctgtttgta tacgggacat taagaaagca 1387801 tgaaaaaaac catcatttgc tggcacaatc ggcatgtatc aatgagcagg cgagaacaaa 1387861 gggaagtttg tttgctgcaa aagaggggcc cacagttgtt ttcaatgatg aagatgaagg 1387921 ctatatatat ggcgaagtat atgaagcaga tgaattgtgt atacataagc tcgatcaatt 1387981 ttttcaagga tatcataaac aaacggtgtt tgtagaaacg gatgtcggga ttaaaattgc 1388041 gcttatttat tttatgaaca aagacgggtg tgccggtttt acgaaaataa gcagcggcga 1388101 ctggaaagaa catcagatga tcagcaaatc gaaaaatccc atttattatt ttgcctatgg 1388161 atcatgcatg gataatgccc gctttcaaaa agcgggagtc gatcactatt ttcaagatcc 1388221 agtaggaaga gctgttttaa aaggatacac aacccgcttc acgctaaaaa gggaagacgg 1388281 ttcaagagcg gacatgttgg aagacggagg aacaacagaa ggcgttttat accgtatccc 1388341 ttattctgct ctctcctatc tatataaaag ggagggcgtc gaatctctta cgtatcggcc 1388401 ggcatttgta gacgttgaag ctggcggaag gcactacaaa gactgtttaa cctttctcgt 1388461 cctccaaaaa gaagcggaaa ttgccccgcc tcagcactat cagattgaaa tcgaacgcgg 1388521 agcggagctg tatttgtcgc ctgagtttac tgaaaagctc aagcggcata tgaattcgct 1388581 gccaaaagga taacactgta acaaaagaat atgataaaat ttgatcaata tcatgtcata 1388641 taaaggagca ccacgatgaa aaaagaattt gcggtaattg ggctgggccg ttttggtggc 1388701 agtatttgca aagcattaag cgaagaaggc gtcgaggtta tggcaatgga tatcgatgaa 1388761 gataaagtca acgagtatgc caagattgca tctcacgcag ttatcggtga ttcgacagac 1388821 gaatctgtcc tgaaaaattt aggcctgcga aattttgacc acgttattgt agcaatcggg 1388881 gaaaatattc aagcgagtat tttaacgaca ctcattctga aagaacttgg cgtccatacg 1388941 attacagtta aagcgcagaa cgattatcac gaaaaagtgc tgtctaaaat tggtgcggat 1389001 cacatcgtcc acccggaacg cgatatggca aaacgaattg cgcataatat cgtgtccaac 1389061 aatgtacttg actatttgga gctgtctgaa gagcatagtc ttgttgaaat cgtagctaac 1389121 agccgcctgg ctggaaatac gcttctcgat ttagatattc gcgcaaaata cggtattaac 1389181 atcgtagcca taaaaagggg caaggaagtc atcgtatcac cgcttgcaac cgaagtcatc 1389241 caccaagaag atatactcat tgttattgga tcagttacag acatctcccg tttcgaaaaa 1389301 agagttcttc atacaaaata gcagccaaat aagccgtcct caaagggcgg tttttcatat 1389361 tatcagaata taacaacttt aatgaactga gcgtcaattt cttaaaattt cattgactaa 1389421 gcacaggcgt tccgatagca tattgtacca tataataaaa aaaggagggg cctatttgaa 1389481 taaagaagcg ctagtcaata ggctgaatgc ttcagccaaa agacaaaaag ctgatatcgt 1389541 cattaaaaac ggaaaaatca tggacgtata taatcaagaa tggatatatg aagatattgc 1389601 gattacagat ggagttattg taggcctcgg tgagtatgaa ggcgaaaata tcattgatgc 1389661 agagggacaa atgattgttc cgggttttat tgatggacat gtacatattg agtcgtcaat 1389721 ggttacaccg attgagttcg ctaaagcagt gttgcctcat ggcgtgacga cggttgttac 1389781 agatccgcat gagatcgcga atgtgtctgg tgaaaaaggg attgagttta tgcttgaaca 1389841 agctcggcat acaccgctga atatccattt tatgcttcct tccagtgtgc ctgccgcaag 1389901 ttttgagcga tcaggcgcaa ttctcaaagc tgccgatctc aagccttttt atgaagaaga 1389961 agaagtatta gggctggctg aagttatgga ttatgtgtcg gttcagcagg ctgaaaaaga 1390021 catggttcag aaactgcttg atgcccgtgt ggcaggaaaa aggatagacg gtcatttagc 1390081 tggtttatca acagacctca ttaacattta cagaaccgca tttgtcttaa acgaccatga 1390141 agtaacatcg aaggaagaag cccttgatcg tatcagaagg ggcatgtatg tcatgatgcg 1390201 tgaaggatca gtcgccaaaa acacgctcaa tgtgctgccg gcggtgaatg aaaagaacgc 1390261 acgccggttc tttttctgta cggatgataa gcatgtggat gatttattgt cagagggaag 1390321 tgtaaaccat caggtgaaaa tggcgattca agccggactt aatccgtttt tagcctatca 1390381 gctaggaagc ctcaatgcag ccgaatgcta cggattagat acaaagggag cgattgcccc 1390441 gggttttgac gctgatttgc tttttgtatc tgatctggaa aatgtcactg tcacaatgac 1390501 gatggtaaaa gggcagactg ttgctgaaga cagcaaagcg gtctatcagg atcatgcttc 1390561 aactgcagca ccagatcagg cactgcttga ttctgttaag cttgctgctc ctcttaacaa 1390621 acaggatttt catatgccaa tcgattcaga gcagcagatc aatgtcattc aaatcatacc 1390681 aaatcagctt gaaacacgat tagtacaagt tccggctcct gttgcccgcg aatttgagcc 1390741 tgacactgag cttgatttgt taaagattgc agttgtcgag cggcataaag gattaaaaga 1390801 aaccggactt ggtgttgtga aaggttttgg attcaagagc ggagcgattg ccacaaccat 1390861 ttcacacgac tcccataata ttattgccgt cggaacgaat gatgaggata tcgcggcggc 1390921 agttaataag ctgcaggaaa ttggcggagg attaacaatt ataaaaaatg gggaagagct 1390981 ccattcagta ccgctgccga ttgcagggtt attatccgac caatctgcag agcaagtgaa 1391041 tcaaagcttg ctgacgcttc atgataaatt gtcgttaatc ggtttcacag gcggatttaa 1391101 tccatttttg acattgtcgt ttttagcgtt gcctgtcatt cctgatatta aaatgacgac 1391161 tacgggatta ttcgatgtaa aatcatttca acacatatca ctgcaataaa aagaggcact 1391221 cccttaggga gtgcctcttt ttttaaacct ccataatgat cggcaggatc attggacggc 1391281 gctttgtttt ttcgtacaag aaaggtgcaa gcgtgtctgt aatttcgttt ttgatttcag 1391341 accattgagt cgtttttcgt tccattactt tttgtaagtg atttgaaatg agctcttgag 1391401 cgtcgttgat caagtcacca gattctctca tgtacacaaa tcctctggaa atcaaatcag 1391461 gacccgctga aatcttgaag tcgtccatgt caatgctgac aacaacgatg acaagtcctt 1391521 cttcagagag aattctgcga tcacgaagta cgatattgcc aatatcaccg ataccgcttc 1391581 cgtcaatgta cactgaaccg gacgggattt ttcctgcaac tgaagcctca tcgcctttaa 1391641 gtgctaatac ttcaccatta tccatgataa agcagttttc ctctgggatg ccacaatctg 1391701 ttgcaagttt gacatgcatc ttttgcattc tgtactcacc gtgaatcggc atgaagaatt 1391761 taggcttgat taaacgaagc atcagcttct gttcttcctg tccgccgtga ccggatgtat 1391821 ggatatcgtt aagagggccg tgaataacct cagcacccgc acgatacagc tggttgattg 1391881 ttcgactcac gctgattgtg ttgcctggga taggggatga agaaaatacg actgtatccc 1391941 caggattgat tgaaatttgg cggtgtgtgc cgtttgcaat tcttgataac gccgccattg 1392001 gttccccttg gcttcctgta cataaaattg ttactttatt agcaggcata cgattgattt 1392061 cgttatgctc aataaacgta tttttaggac agttaatata accgagtgtc tgtccaattt 1392121 cgatagccga ttccatactg cgtccaaata cggcaacttt tcttccattt tgtacagcag 1392181 cttcaattac ctgctgcaag cggtgaatat tcgacgcaaa tgtggcgaag ataattcggc 1392241 cgtccacctt gcggaaaatg tcatgaatgc tttctcctac acggcgctca gacatggtaa 1392301 actccggatt ttcactgttt gtgctgtctg aaagaaggca caaaacgcct tctttaccga 1392361 tttcggccat tttcgttaag tttgccggct cgccgactgg agtaaagtcg aatttgaaat 1392421 ccccagtatg tacgatgttt ccgggcggcg tttttacaac aatgccgtag gaatccggaa 1392481 tactgtgtgt tgttctgaag aatgacacag ccgttttgcg gaactttaca atatcatcct 1392541 cgccgataat gttcagtttc gtctgtctca ataatccatg ctcttcaagt ttattccgaa 1392601 gtaagccgat cgcgagtttt ccgccgtata caggaatatt cacttgtctg agcaggtatg 1392661 gaataccgcc gatgtggtct tcgtgcccgt gggtgataaa aagcccttta attttatctt 1392721 cgtttttgac taaatacgta taatcaggga tgacgtagtc aattccgagc agttcgtcct 1392781 cgggaaactt gatccccgca tcaatcagta caatttcatc ctggaattgc accgcgtacg 1392841 tatttttacc gatttcgccc aaacctccga gggcgaaaac agcagtctga tcatttttta 1392901 caaatttcat accgctcata actccaatac tttaaaattt tcgctctgtt gttcatattc 1392961 taagaatgca ccatcaacag gtgtaataaa ctcaatatta aatttctttt ctttcagctt 1393021 tgttctgacg tcacgctcag atacgccttc aatataaagt gaatctgtct tttcccgaac 1393081 aggtacttcg tcagccttct cttgataaaa taccttataa atcattccaa atctctcctt 1393141 aaatgccgta tgttagactc gctcattcta ttatattcga aaacggaata taaggaaagc 1393201 cttgagcaaa ataaggatct ctcaaaaagt gaaagatccc ttgtcaggca attgctttct 1393261 tacggagcat tccgttccat tgtcttctga gtttctttct taatttacgc agcattagcc 1393321 agtccctcct ttaatgaaaa atttgtccca gagttctttt atacaaatag tatacggaga 1393381 ttgaggaaga cttttcgtgg ttattaatgg aatttaatat gatttttgaa cgaaattgtt 1393441 tgctgaatga caatcttttt gtatgatgag ggtgggaatt gcagaccaag acgataaagg 1393501 ggaagttgcg atggattcta aattaatctt ttttgatatt gacggcacaa tatatgatca 1393561 tgataagaat ataccggaaa gtacgagaaa aaccgtggcg gagcttcagc gccaagggca 1393621 tcatgtgttt attgccagcg gccggtctcc atttttggtt aagccgattt tggaggagct 1393681 gggcatccac tcatttattt cctacaatgg acagtttgtt gtctttgaaa atcaagtgat 1393741 ttataaaaat ccgctgcctg aaaatgcaat caggcgatta ttaaagcagg cggatgaagg 1393801 caagcatcct gttgtgttta tggctgagga cacgatgaaa gcgactgttg cggatcaccc 1393861 ccatgttctc gagggaatcg gcagccttaa aacagattat ccagagaccg atgacctttt 1393921 ttatgaagga aaagaaattt ttcagcttct tttattttgt caggatgaag aagaaaaagc 1393981 ttatgccgct tttcctgagt ttgatctagt tcgctggcat gagctatcga ctgatgttct 1394041 gccgcacgga ggttcgaagg cagaaggaat caaaaaagtg attgagcgtc ttccgtttga 1394101 tatcggcgat acatatgctt tcggcgacgg attaaatgat ttgcaaatga ttgaatacgt 1394161 tgggacaggc gttgctatgg gaaatgctgt tcccgaactg aaagaaatcg cggactttgt 1394221 aacaaaaccg gtggacgagg atggaattgc atacgctgtc aaagaattgg gccttttaaa 1394281 ataaagaaac ggctggcatt gtgccagccg ttttctcttt tagcgctcaa ttgcgattgc 1394341 attttcaggt tctttgaaag gattttcctt atcaatatga tcatagaaca taacgccgtt 1394401 caaatgatcg atctcatgct gaaacacaat agccggaaat ccttttaaac gaatatcaat 1394461 attttcgcct tctagtgttg ttccttttac tctgatgcga gcatagcggg gaacataacc 1394521 gggaatcgct tcatccacag agaggcagcc ctcgccgctt gttaagtagc ttttttcaac 1394581 tgaatggctg acgatcttag gattaaacag agcatagctg tataatttac cggaagcatc 1394641 ttccgcatga acggcgatca ttcgtttttt gatattaatt tgaggagctg cgagtcctac 1394701 gccagggcgc agcttgtatt tttcggctaa ttctggattt tggctgtttt taacaaattc 1394761 gatcatgtcg gccagctgct gtttttctgc atcagttgga ggcagctcaa caggttcggc 1394821 agtctctctg agggctggat ggccgtcacg tacgatgttt tccatagtaa tcaagaaact 1394881 tcactcctaa agcttaatat gtaaattata tcggatttct tcacaaaggt gcaacgaaac 1394941 gaatgaccag ccgtatatgg ctggtcaatt tcatgctgtg tggttagcaa cagcctccac 1395001 ctaaataagc agctccgaca atgattaaca gaatgaataa aacaacgatt agcgcaaagg 1395061 tgcggccgta gccatatccg cagccaccat atccgtaacc accataactg cagcagcctc 1395121 cgccgtaacc atatccatac atattacata acctcctctt ttaattacgc cagagccttt 1395181 ataagtaggc atagcgtcta atataaccta tgtaaaaaca aaaaagttgt atggtcatct 1395241 gtcctgattt ttcacttttt tgatttaatt tcagtattgc atttatacag cacggctatt 1395301 gccaaatgtc cccatggatt ctatagtaga aattgtcaag attgggggat ttaacgtgaa 1395361 agacgctata aaacggcggc ctggaatcaa gatcggagct ttttgtgcca tggcactgat 1395421 attaacagga tgcatgggac aggacccggt tgattcactt catcattcat tagaaaaagc 1395481 cgcggaatcg gaaaagccgt ttcaagaaga acaaaacaca ctcaaagaat tagaggccaa 1395541 agaaaatcag ctttacgata gtgttatgaa gctcaatatg gatgattata aaaaaattgt 1395601 tgctttatct aataaggcgc ttgaaaatgt cagcaagcgc gaagaacacc taaagcttga 1395661 aaatgacagc atgaaaaaat cggaaacaga atttgaggaa gcaaaaacgt cagcggaaca 1395721 tattaaggaa aaagacataa aagaaaaggc cgatgccgca gcaaaccata tggagaaaag 1395781 atatacatca tatggcacta tgtataaaga gtataaaaaa gcgcttgagc ttaataaaaa 1395841 actgtatatg cagctgaaag acaaagattt gacaagagat gatctggatc agcagatcga 1395901 taaagtcaat gcttcttatg aaaagatcct taaatatagc ggagaattta atgaacaaac 1395961 cgaaaaatat aataaagccc gggaagattt atatgatgct gcaggctatc gtgtgaaaaa 1396021 gagctgactc gatcagctct ttttttgaat gaaatgcgat tcggatttcg ttcaaaattt 1396081 tcatttctat tgtagtacag catagtaagg tatactagta cagttttggg tgcggttggc 1396141 atctgttttt ttgatgaaaa tgtaaagcga atacatttat tgaaaatcag cgatgaaaac 1396201 gattgacggt tcttctttat ttggtgtaaa ctaatccatg ttaagcggtg ttgtattagt 1396261 tttttacaac ttcgaaataa tacagttcaa agcagagtgt aactatccta cataaaaggt 1396321 tttggcaaac tggggatcgg ctaaaatata atacgactta ctgctgatac tttagggtac 1396381 cctaagtttg tatgtataaa aggaatgcac gtctaatgac tgtttaaaag aaaggaagag 1396441 gtgacttagt atggctgcaa aaacgaaaaa agctatcgtt gacagtaaga agcaatttga 1396501 tgccattaaa aagcagttcg aaacgttcca aattttaaat gaaaagggag aagtcgtgaa 1396561 tgaagcggcg atgcctgatt taactgatga tcaattaaaa gagctaatgc gccgcatggt 1396621 atttacgcgt gtgcttgacc aacgctctat ctcattaaac cgtcaaggac gtctcggatt 1396681 ttacgctcct actgcgggtc aagaagcttc tcagattgca acgcatttcg cgcttgaaaa 1396741 agaagacttt gttcttcctg gataccgtga tgtgcctcag ttaatttggc acggccttcc 1396801 attatatcaa gcgtttcttt tctctcgcgg acatttcaga ggaaaccaaa tgcctgatga 1396861 tgtgaatgcc ctttctccac aaatcattat cggtgctcaa tacattcaaa ctgccggtgt 1396921 tgcgctaggt cttaaaaaac gcggtaagaa agctgtcgca atcacttaca ctggtgacgg 1396981 cggagcttct caaggggact tctacgaagg aattaacttt gccggagctt ataaagcacc 1397041 tgcaatcttc gtggtgcaaa acaaccgtta cgcgatttca actcctgttg aaaaacaatc 1397101 tgcagctgaa acaattgcac aaaaagctgt agctgccggt attgtcggcg tacaagtaga 1397161 cggaatggat ccgcttgctg tatacgcagc aactgctgaa gcacgcgagc gcgcaatcaa 1397221 cggcgaaggt ccaacactaa ttgaaacact tacattccgt tatggcccgc acacaatggc 1397281 tggtgacgat cctactaaat atcgtacaaa agaaatcgaa aatgagtggg aacaaaaaga 1397341 tccgcttgta cgtttccgtg cgttccttga aaacaaaggc ttatggtctg aagaagaaga 1397401 agcaaaagtg attgaggatg cgaaagaaga aattaagcaa gcgatcaaaa aagctgatgc 1397461 tgaaccgaag caaaaagtaa ctgatttaat gaaaatcatg tacgaaaaaa tgcctcacaa 1397521 ccttgaggag caatttgaaa tttatacaca gaaggagtcg aagtaagcca tggcgcaaat 1397581 gacaatgatt caagcaatca cggatgcgtt acgcacagaa ctgaaaaatg acgaaaatgt 1397641 cttagttttc ggagaagacg ttggtgtaaa cggcggcgta ttccgtgcga cagaaggatt 1397701 gcaaaaagaa ttcggtgaag accgtgtgtt tgacacgcca cttgctgaat ctggtatcgg 1397761 cggtcttgcc cttggtttag gcttaaacgg cttccgtccg gtaatggaaa tccaattctt 1397821 cggatttgtt tatgaagtaa tggattcagt ttctggccaa atggctcgta tgcgctaccg 1397881 ttctggcgga cgctggactt cacctgtaac aattcgttct ccattcggcg gcggtgttca 1397941 tactcctgaa cttcacgctg acagcttgga aggtcttgtt gcacaacagc ctggtatcaa 1398001 agttgttatt ccatcaactc cttacgatgc caaaggactt ttaatttctg cgatcagaga 1398061 caatgatcct gttgtcttct tagagcatat gaagctttac cgttctttcc gtcaggaagt 1398121 tcctgaagaa gaatacacaa ttgagcttgg aaaagctgac gtgaaacgtg aaggtactga 1398181 tctttcaatc atcacttacg gcgcaatggt tcatgaatca ttaaaagctg ctgatgagct 1398241 tgaaaaagac ggcatttctg ctgaagttgt cgaccttcgt acagtaagcc cacttgatat 1398301 cgatacaatt atcgcctctg tagaaaaaac aggacgcgcg attgtcgttc aagaggcaca 1398361 aaaacaagcc ggtattgctg caaacgtagt agcagaaatt aatgaccgtg cgatcctgag 1398421 cttggaagca cctgtacttc gcgttgcagc gccagataca gtatttcctt tctctcaagc 1398481 ggagagcgta tggcttccaa accataaaga cgttcttgaa acagcaagaa aagtgcttga 1398541 attttaatca aactgcataa tcgagaggga agatgaacgt tttccctcta ttatatatct 1398601 gttttcaatg cttacgatgt aaactttaaa attgcttaat caaactagga ggtcgagaac 1398661 tgtggcattt gaatttaaac ttccagatat cggggaaggt atccacgaag gcgaaatcgt 1398721 aaaatggttt gtcaagccta acgacgaggt agacgaagat gatgtactgg ctgaagtcca 1398781 aaatgataaa gcagtagtag aaattccttc acctgttaaa ggaaaagtat tagaattaaa 1398841 agttgaagag ggaacggttg caactgttgg acaaacgatt attacgtttg atgcacctgg 1398901 ttacgaagat cttcaattta aaggcagcga cgagtctgac gatgcgaaaa ctgaagcaca 1398961 agttcagtca actgcagaag ctggacaaga cgttgcgaaa gaagagcaag ctcaagagcc 1399021 tgcaaaagct actggcgcag gacagcagga tcaagctgaa gttgacccga acaaacgcgt 1399081 gatcgctatg ccttccgtac gtaaatatgc acgtgaaaaa ggtgtagaca tccgtaaggt 1399141 tactggttca ggcaacaacg gacgtgttgt aaaagaagat atcgacagct ttgtaaacgg 1399201 aggagcgcaa gaagctgcac cgcaagaaac agctgcacca caagaaacag ctgctaaacc 1399261 ggctgctgca ccagctccag agggcgaatt cccagaaaca cgcgaaaaaa tgagcggtat 1399321 ccgtaaagca attgcaaaag cgatggttaa ctctaaacac actgctcctc acgtaacgtt 1399381 aatggacgaa gtggacgtaa caaaccttgt tgcacatcgt aaacagttca aacaggttgc 1399441 tgctgatcaa ggaatcaagc tgacttactt gccttacgtt gtaaaagctc ttacatctgc 1399501 actgaaaaaa ttccctgttt taaacacgtc aattgacgat aaaacagatg aagtcatcca 1399561 aaaacattac ttcaacatcg gtatcgctgc tgacactgaa aaaggcttgc ttgtaccggt 1399621 tgtgaaaaat gcagatcgta aatctgtctt tgaaatttct gatgaaatca atggccttgc 1399681 aacaaaagct cgtgaaggca agcttgctcc agctgaaatg aaaggcgcat cttgcacaat 1399741 tacaaacatc ggttctgccg gcggacaatg gttcactccg gttatcaacc atccagaagt 1399801 tgcgattctt ggtatcggac gcattgcaga aaaagcgatt gttcgtgatg gcgaaatcgt 1399861 agcagctcca gtcttagctc tttctctcag cttcgaccac cgtatgatcg acggagcaac 1399921 tgcgcaaaat gcattaaatc acatcaagcg tttactgaac gatccacaat taattttaat 1399981 ggaggcgtaa tgttatggta gtaggagatt tccctattga aacagatact cttgtaattg 1400041 gtgcgggacc tggcggctat gtagctgcca tccgcgctgc acagcttgga caaaaagtaa 1400101 cagtcgttga aaaagcaact cttggaggcg tttgtctgaa cgttggatgt atcccttcaa 1400161 aagcgctgat caatgcaggt caccgttatg agaatgcaaa acattctgat gacatgggaa 1400221 tcactgctga gaatgtaaca gttgatttca caaaagttca agaatggaaa gcttctgttg 1400281 tcaacaagct tactggcggt gtagcaggtc ttcttaaagg caacaaagta gatgttgtaa 1400341 aaggtgaagc ttactttgta gacagcaatt cagttcgtgt tatggatgag aactctgctc 1400401 aaacatacac gtttaaaaac gcaatcattg ctactggttc tcgtcctatc gaattgccaa 1400461 acttcaaata tagtgagcgt gtcctgaatt caactggcgc tttggctctt aaagaaattc 1400521 ctaaaaagct cgttgttatc ggcggcggat acatcggaac tgaacttgga actgcgtatg 1400581 ctaacttcgg tactgaactt gttattcttg aaggcggaga tgaaattctt cctggcttcg 1400641 aaaaacaaat gagttctctc gttacacgca gactgaagaa aaaaggcaac gttgaaatcc 1400701 atacaaacgc gatggctaaa ggcgttgaag aaagaccaga cggcgtaaca gttactttcg 1400761 aagtaaaagg cgaagaaaaa actgttgatg ctgattacgt attgattaca gtaggacgcc 1400821 gtccaaacac tgatgagctt ggtcttgagc aagtcggtat cgaaatgacg gaccgcggta 1400881 tcgtgaaaac tgacaaacag tgccgcacaa acgtacctaa catttatgca atcggtgata 1400941 tcatcgaagg accgccgctt gctcataaag catcttacga aggtaaaatc gctgcagaag 1401001 ctatcgctgg agagcctgca gaaatcgatt accttggtat tcctgcggtt gttttctctg 1401061 agcctgaact tgcatcagtt ggttacactg aagcacaggc gaaagaagaa ggtcttgaca 1401121 ttgttgctgc taaattccca tttgcagcaa acggccgcgc gctttctctt aacgaaacag 1401181 acggcttcat gaagctgatc actcgtaaag aggacggtct tgtgatcggt gcgcaaatcg 1401241 ccggagcaag tgcttctgat atgatttctg aattaagctt agcgattgaa ggcggcatga 1401301 ctgctgaaga tatcgcaatg acaattcacg ctcacccaac attgggcgaa atcacaatgg 1401361 aagctgctga agtggcaatc ggaagtccga ttcacatcgt aaaataattt tcatatcaaa 1401421 aacagccccg ctttgagcga gggctgtttt tttattttga cagcacatgc tgtaatggtt 1401481 taatgatgtc ttctttcttt ttcacacatc cctcgatttt caccacgaca tggcgctgat 1401541 caacaaccat aagggtaggg acagtttcaa tctcatcttc ccagccttct tttttatcat 1401601 agaccttcat tttatctatt tgctcgggat aatctttttc taaatcaagc agtgcatcgt 1401661 aataaggcgc ttcctggtct atttggttct catcagaaaa aaacaggatt tgtgtatgat 1401721 gaatgttgtc aatccggctt tttttcatcg gattgatggt ggaaagcgta cagcccgata 1401781 aagcaaatac tattatcagc atggggaata ccgcgcgata tcgcatctat cttctcctct 1401841 gtataaacag tagttaacta gctttagttt atcacgagag acggcttaat ctgcttcttg 1401901 ttacctaatt gttatataat tgaaaccgtt tttaaagtga gattacatat tatatcaatc 1401961 gtttaaaata gcaacctggg gtatattgaa ttttttgctg cattcttgga tgaaagttca 1402021 agaaaacgtg caattacatt atgtgctgtg gcatatatat cgagtaaagc ttctgtatga 1402081 agaagatatt gtatgatgga aaatggaaaa acaaggtgaa tatgatgata tgaaataaaa 1402141 tgtgttatac agtttgttgt tgacatttta aatgtgacat attaatataa taacaacaaa 1402201 agaaattaag cgttttcaaa tttcaaagaa atggggaata agagatgggt acgattgttt 1402261 gccaagattg caacgaagcc attcattact ttgaagatga gaaagtgaca acattatatg 1402321 gaacttgctg cggacaatgt caatgtcctg ttgatgaaga gtaaaaaaaa gcatgcggct 1402381 taaagccgca tgctttttat tttttattga attgcttttt gttctttgat gacccggatc 1402441 atatgtaaag tcgagtcctc aggtccttga acagggaggc ctgcgtcaag gtttttaaaa 1402501 atgtagctga tgttttcttc tgtaataatt tctcctggga tgaagattgg aataccaggc 1402561 ggatatacca tgacaaattc agcaataatc cgtccggatg cttcttttaa tgggatgact 1402621 tccgtatttg catagaaagc atcacgcgga gtcattgcca ataaaggtat ttctggaagc 1402681 agaacctcag tttgctgatg tgttacatct tgttctgaca tttgctgtgc gatctcagtt 1402741 aaagcctcta caagccggtc tgcatcattt tggctgtcac caggagtgaa aatacacaaa 1402801 atattgtaca gatcagaaag ctccacctca atattaaagg attcacgaag ccatttttcc 1402861 acgtcatgtc ctgtcaggcc aagacttttc acagagataa tcaattttgt cggatcatag 1402921 ctgtaagctg ctttcgaccc aagaatctca gaaccgacac aataaatgcc ttcaatctga 1402981 ttgaggcgat ctctcgtctg attggcaagc ttgagtgttt cctcagcaag ctggcggcct 1403041 tctgttgcaa ggcgttttct ggcaacatcc aaagaagcga gaagcaagta agaagttgac 1403101 gtagttgtca gcatgctcag gatggattgc actctgtctt tagatacaag gccttctctc 1403161 atgtttaaaa tagagctttg tgtcagtgat ccgcccagct tgtgtacact tgtcgctgct 1403221 atgtccgctc ctgcctgcat agccgatagc ggcaattcgt cgtgaaaatg aatgtgaacg 1403281 ccgtgtgctt catccacaag cactggcaca tcaaacgaat gagcgagttc tacgatgctt 1403341 tttaagtcgg ctgcaacacc gaaatatgtc gggttgatga cgagaagccc ttttgcatcc 1403401 ggatgctcgg taagcgcccg tttagcagat tcaagtgtaa ttccgtggga gatgcccaat 1403461 tcattgtcaa tttcaggatg aataaaaatt ggaaccgctc cggaaaatac aatagctgtc 1403521 ataattgatt tatgaacatt tcttggaata ataattttat caccaggtcc gcaaacagcc 1403581 attaccattg tcataatggc gccgcttgtt ccttgaacag aaaaaaatgt atgatccgct 1403641 ccaaatgctt cagcagccag atcttgtgct tgtttaataa tgccttttgg cgcgtgcaga 1403701 tcgtctaatg gttcaatatt aatcaaatct atgcttaacg cgttttcacc gataaattgt 1403761 ctgaattctg ggtccattcc tgcccctttt ttatggccgg gaatgtggaa ttgaacaggc 1403821 tgtctgcttg catgcttttt cagtcctgtg tataagggtg tttcatgttg cgacaattgt 1403881 tttcccacct ttgtaatcat acctatgcat aatagtgtgt attaaaatca gtttctcaac 1403941 cgttttttag acgtaaaaca aatgaattat attatgaact tgaaagaatg taaagaacaa 1404001 tttatgatca aatgaagatg ctttctctta agggaagtaa atctacaagg agtgaagaaa 1404061 atggagtatc aatatccgat gaatgaagat tggacaaccg aagaagcagt ggatgtgatt 1404121 gcatttttcc agcaggttga gcttgcatat gaaaaagggg cggatcgtga agaactgctt 1404181 aaagcttacc gccgtttcaa ggaaattgta ccggggaagg ccgaagaaaa aaagctatgc 1404241 ggcgagtttg aggaacaaag tacatattct ccttatcgca cggtcaaaca ggcgagagaa 1404301 tctgatcacg cgaagattaa gatgtaagaa aaagagccgg gggatatccc ggctcttttt 1404361 tatgcttgtg ttactttttg ggtgagacgg tacagaaaag caagctgttt aaaggcatcg 1404421 tcgatacgct gaaggaattc ctggttattc atattcagca cttcttcttt ttggagctgg 1404481 atgccgcata acagctcggc tttctttaca gtctgcaaac gctcaaacag tgtcttcagc 1404541 tgttccttgt ccatttcaga ctgtttatgt actcccggtt ttgtgtgatc tgcagaccaa 1404601 acgaagctgt cagggatatt tttcgtaatg gtttcttggt tcacttcaag caatttgccg 1404661 tattcttctt tgatagggga ttcataaata atcgcgaacc atacaaagac gtggctttcc 1404721 cataaaccaa tttggaaatg cggcagtttt ttatagcctc ttttgctgtt tgcgaacgcc 1404781 acccagctgt cagccggggg attgacggat cttcttgcgt gctttgccac atgcggaaac 1404841 atttcatctc cggttaaagc tgataaagtt ggggcaaaat gttcgcctag agctgtaagc 1404901 ttcggacgga ccgtctcttt taatacttcc atgcgcgcgt ctaagccttc tattgtaaat 1404961 gtgttaaagt cttcttcagt gaaacgcatt tgtgtcatga ttttcctcct tcatgctaag 1405021 tatacatatt ttatcacagt tcatacgagc ttcaaaaaga ttgagcgcgt ttgaagtaag 1405081 gagaaatgtg gtaataaacg agtaggtaaa cacacaattt tcagaatcat gttgcgcgta 1405141 aatagaacaa tcatacgata taagaagtaa tcattgttga atggcaaaat gggatgcttt 1405201 tttacaaaca aatgatctct ggaaggggcg aaagacaatg aggcaagttg taaaagaggg 1405261 atttaaggaa gagaaaaaca atcgtgttgc tgtctggaga ctagaggttg attatgaatt 1405321 ggcaacccta tatgaagcaa tgcagaaaga aaatgaagag cagattgaac aaagcaaaaa 1405381 caaacttgag cgacttagaa aagaatggat tcgtcttaac gggtaaaaaa gcgatagtga 1405441 aaacgaaccg catgaatggt tcgtttttac gtgagaaggg atatttttca ttttccttgc 1405501 tttttcattg ccgttatcag tatcctataa aataaaaggt ctacatagaa gagaggtacg 1405561 aacgaatgac aaattggacg gaaatcgatg agattgcaaa gaaatggata agagaagcag 1405621 gcgcgagaat tacacaatcc atgcatgaaa gcctgacaat tgaaacgaaa tcaaatccga 1405681 atgatttagt caccaatatt gacaaagaaa ccgaaaagtt tttcattgat cgaattcaag 1405741 aaacatttcc gggacatcgg atactcggtg aagaggggca aggagacaaa atccactcac 1405801 ttgagggagt cgtatggatt attgatccga ttgatgggac gatgaatttt gtgcaccagc 1405861 aaagaaattt tgcgatttcc attgggattt ttgaaaacgg tgaaggtaaa atcggtttaa 1405921 tttatgatgt ggtgcacgat gagttgtatc acgcatttag cggcagagga gcttatatga 1405981 atgaaacgaa gctggctcca ttaaaagaaa ccgtcattga agaagcgatt cttgccatta 1406041 atgcaacatg ggtaacggaa aacagaagaa ttgatcaaag tgtgttagcg ccacttgtga 1406101 aaagagtcag aggcacacgc tcctacggtt ctgccgcttt agagctggca aatgtcgcgg 1406161 caggaagaat agatgcttac atcacgatgc ggcttgcgcc atgggactac gcagccggct 1406221 gtgtgctgtt aaatgaagta ggaggcacct atacgaccat tgaaggagag ccgtttacct 1406281 ttttagaaaa ccacagtgtg ctagccggaa acccatctat acataaaacg atatttgaag 1406341 agtatcttca tgctcggaag taggccattt gagcaggatg atctcagctt gttagaaaag 1406401 ctcgcggagg ctcatcctgt atggaaagag gaggagtttg gagataaaga tgcagaagac 1406461 tatatcattt cctactccat gtacaacggt tcatggcttg tatgggaaaa agacggtatg 1406521 cctgttgccg tcagctacca tctcgagtgg tctccttcaa acggtaagcc gtggctcgga 1406581 acggtcctga ttgacccggc tgaagaaaaa aagggacatg cgaagatgat cattgaacag 1406641 atcagcaaat tgcttagagc gaaacataaa gcgatgtttg cgggagttcc cattgagcgc 1406701 agggaatgga tactgttttt aagccaatgc ggctttgaac agctgaaaac ggaaaaagat 1406761 gagaaaggca aatcatttat gatcttggtg aagcctttag cagaagctgc cgtatgataa 1406821 tggcagctta tttgctgcat gcgggttcaa taaaaagcct ctcaaacatt gagaggcttc 1406881 tgatgatttg aaaattattt ttttaccgca tgaatataat gaatcgtttc aaacgctgac 1406941 aaattgtctt ttcgattact aaagaaaagg tcattgatgt cgtctggtga tagatgttca 1407001 tagatcagta aaccagatga ctctaacaga tgttcaatct cttgataagt gaaacatgat 1407061 ttcatcggtt ccccgcttgc ggcagccatc ttcaccatat gttcaactcg attcgacgtc 1407121 ccttttgctg taaaaagtgt ttcgtccgca taatcaaaaa caatagagct tccaggcggg 1407181 acatgagaaa ataaattgct gatcaagctt gcattttctt cccgtgttac ataataagac 1407241 actccgagaa ggctgaagaa tgtttttgtg tttttaaatc cttcatctaa gagaggatca 1407301 tacgaaaacg ttttggtgaa atccatagga acaaaatgaa gatgacccgg aattgtcaga 1407361 tttgcatcct tcagcttatt ttttttcaat tgctgtgtgg ccggatgatc aacctcgaaa 1407421 acctgtaagc tgttttctaa ttctggatgc cgaaagcaga aagtatccag tcccgctcca 1407481 agaatgacat actgttttgc ccccaggatt aattcgttgt gcaagacttt ttcacaataa 1407541 gaagcacgtg ctaggggcgt tggagacagc tggatttgtg caacccattt taatattttt 1407601 tcaggatcat tttgaagacg ttcggcgatc tctttgttga aaaacgatat ttcttgaatc 1407661 atatttttac tgatgtcgat aaactctttt tcgttaatga gatcttttgc gataaaatca 1407721 tcaaaaataa gaggtgtgtc atatcggctg tgatatgcac gggcaaaagc tgaaattaga 1407781 gacgttaagc tggactcatt tttcctcatg aaatgatcct ccacaaaaaa taagattccc 1407841 ctggccagga gaatcttatt atacatacaa atatattaat agtaaatttt agcataaata 1407901 aatttttttg tcaatgtttt tgctcttaac tggacgcgcg atccttcaca tagccacgtg 1407961 acctgtagca gaattcgtct atcaattatg tggactgaat cattagcttt tataaaatgc 1408021 gcacttgcgg ctgcatccct ctttatgcaa atcaggagcg gttttctgtc tcatggcagc 1408081 atcttttcgt cgtttcagct gagagagaaa tcaagatatg taacaataaa agcctgaggg 1408141 atctcaggct tttcctaata ttacaatcca acagcattcc aggctgcttc aactttagcg 1408201 gcatcagttg agccgtagag gtcacgggca gactgaatga gagctgcctt ggcatctttg 1408261 aacgtggaag aaggcgtgag gtacgttgtt aacgcacggt aatagatttg ctgtgattta 1408321 gatacaccaa gttttgtgat ggtgttgtaa gcggctttgt ttggaattcc gctgtttgtg 1408381 tgtacaccgc cataatcgcc ttcatctgtg tttggaaggt ttcggtaatt ggcgtaattg 1408441 tcaggctggt tgtattttgt agggttggac aggctgcgaa gagcaggctg gctgaccgta 1408501 atgtcttcac cgatgtccca gtcttctgta tcgttaaaat acccgaatac gtcagagaaa 1408561 gactcgttta atgcacctgg ctgattttca taaatcaagt tggctgtttc ttgggtgacg 1408621 ccatgtgtca tttcatgcgc tgtcacatct aatgagccgg aaagcggaga gaagaatgaa 1408681 ccgtcgccat caccgtaaat catctggtct cctgtccatg cagcgttatt gtattgagtg 1408741 ccgtagtgaa cggaagaaac gattttactg cctttgttat catagctgtt tcgtttaaag 1408801 tttgaataaa aataatcgta cactttaccg aggttatagt gtgcgtcaac ggctgcccgc 1408861 tgtgatgaag atgtaaatgt tttcgttgtg cttgagacaa gcgtgcccgg aaggcggctt 1408921 tgtctgtttt gcaaatcata tgtgatgatt tgggtgcctg ttggttttga aagatctctt 1408981 agaacatatt ttccgccttc ataagagatg ttcaaaggaa cagttgcgcc ctttagcgtt 1409041 gttccgcttc cagtggcggc ggcatgttct actttatttt gctgttttaa aatgctgcct 1409101 gtttcggcgt caactaagac ttcccagttt gcaggttcag gctcgacata gcgaatcgtc 1409161 acgtcgtaag caagacgata gctgccgtct tttgtttcta tcgcttttaa ttcggcttta 1409221 ttgctgtttt tggccgctcc gttagaaaca gcgtctggtg atttgccgat agctttgaaa 1409281 gcgagtgcca gcgctttttc agaagagact ttttggctgt tatctgtttt tgcagcagat 1409341 tgattgtgta attcaccatt gaccgcatag acattatcgg atttatcgac gtgaacgatc 1409401 acttgcgaat ctttaattgg cactccgtta acgacaggcg catatcgaaa gtgcttgtat 1409461 ccaagggcat cagtcgtgct ttcaacaagc ttcagccttt tggaagggtc acctttaaaa 1409521 atgttgctgt tctttttcaa aaactgcttg acagccttgt catttggtgc agagagttct 1409581 gattgcgcaa tcgcgttttt ggagaggaaa tttgtttgat tctctttaag ctgatgacct 1409641 tcagcagcct gaacacctgg caggctgatt gataaactca taaacgaagc agcgacagca 1409701 acagacaatt tcttacctaa acccacaata aatccccctt tttgaaaata ctgaaaactt 1409761 tatattgtta tattaaacta gcattctgga atactcaaca aaaactaaca taactagaca 1409821 aaattgatag tattgtcctg tgtttgtttt tgttgaataa tatcaagatg agtcaagtgt 1409881 catgtggtgg ttcattcaag agttatgttt tttacatatc aaggggaaga tgagatattt 1409941 ttgtttcatc ttgaaacttt ttgaaaagtc cgctgtctaa ccgaatgagg ccttaataag 1410001 aagtaaagga ttgttgttcg tgttggagtt attcagtcat tatgtattgc atttcgaacg 1410061 ttattttata ttaagcagac aaagcaccct gctgattcaa tggtcaattg ttgttctggc 1410121 gggcttatat cttttggtgc atcatcccaa aataaaccgg cagcgcacaa tgttcttggc 1410181 gggtgttata ttgcggattg tgctgctggc gggagtgtct gttgaactta ttcaccaggt 1410241 gcaatcaaca aacttcacca gcgcttactt aagagaggac ggaaaagaac tgctgccgct 1410301 gctgcatttt ttgttatacg gatatgtgct gctgacggct tttcactata tgctgatgcc 1410361 gcgtgatcat ggcggaaagg gtaagtttta tacgttcgac cttgctgttg tcagtttgcc 1410421 gatcgtacaa atgattttta gtttcttttc gtattggaag gaatacccgg atgggatgga 1410481 gccgattgca ttcgtgtttc tgtttttcat catcactctt cccattgcgt tgaatgtagt 1410541 gtttttcaag ctgtattgga gaacggataa gatcttacta ggcttatttt atacgctgat 1410601 tatcggactg cttgtcttgc tgcttgcgcc atatcccaat caaatctcaa aagattatgg 1410661 tgcagtaatg ccatatacga tttatttggc aatggcggga tttttgatga gctatcatct 1410721 gttccaaaag tcaggaaagg tttatgtgcg tgtgaataag tgggtgacga tggctgtcat 1410781 ggtgtttttt gtcctgctgt taaatccgat atataacata ggaacggctg ctttcgctgt 1410841 atcaaagcca gcaaatgtcc atgattcatt caattttgtc ggggagcaca tttcatcaga 1410901 aaaagcggaa cagatactaa agtcattttt tcctacggat gaaacacttt atttgcacga 1410961 tacaaacatg gatgtgcatt atttctactc atttgaaagc aaaggttaca aagctgaggt 1411021 agatgaagta tcgcagctaa ttcgtaatta tgaatactta caaaaagcac atgggaaaaa 1411081 gctaacgaat caggagtaca agcgaaagtc catcgctttc cttgagcgac acggacgtgt 1411141 gttacataag gatcatatcg aaacaaaggt atctcaagaa gacggccaga cagtcgtacg 1411201 tatttacctg aaaaatcaac ttcataaaaa agatcatgct gatgatggcg cggtatttta 1411261 ttgggaaaag gaaaccttaa tggggtttag tgaagatcct tcgatttatc agcttgactc 1411321 tcttctgcat gttcatataa cggaacaaga cattcacgac aaagtggaac aaatgtttac 1411381 agcgctgaac atatcaaaac agccttatca gatcactgat attgaaagcg acagcctgct 1411441 tggaagcatg gtgagagttg aaacaaaagt tggaattgtt ttggaatttg agggcgaatc 1411501 aggttgttta catagtcttt cgcttccgat gaaaaagaat atctcaatgg ctaacagccg 1411561 gctgcagcat cagatattat cgatcttcga tgctcgtgga tcagaaaaga agaaaaaaag 1411621 cagtcagggt gacatggtga tgtatactga ttcttctaaa acatatgagt ttgttgaagc 1411681 tcaaggtcag ctaaacgttt atgtatacag cgatacacct gatcagtcat tcccctatac 1411741 gtatcgtaat ggaacattgg cttacgaaaa agtagcttct ctatatcagg atgtcattta 1411801 caaaaagcgt atgcgtccga ttatcgttca aagaggggat gaacggcatt atgcatggct 1411861 gatcattatt cagccgtttg gttcaaatcg ccatgatgcc tatgtagtgg atggagaaac 1411921 acaagaggtg aaaagtcttt atgaatcata aagaaaaaga gtctgttttt gtagacttat 1411981 acgacctgta taaagaagga gagctagagg atgaatcaat ggaatggatg aaacagcatg 1412041 aatccctatt tcaaaagaat gcggaagact taaagagtaa aacttgttta aagagaagtc 1412101 ccggtgctga agaagaaagc caaatcagat atatgaaagt atacctgtct tccatgtata 1412161 tctgtttcat tttattggcc atttggatga cggtgtggtt ttatttttaa tgaagcatag 1412221 ggattccatt gaggacttgt atcggcagta ttatcaagaa attttaaatt atttattcag 1412281 aaggactcat catcttgaaa cagccaagga cttagcgcag gacacgtttg taaaagctct 1412341 taacggtctg gcttcgttta gggggcattc ttccatcaga acatggctct acaccattgc 1412401 gcatcatacc tttatcaatt ggtaccgaag ggatgtcaaa taccaattta ctgaaatcag 1412461 caaaaatgaa gggttaacgc aaacaactta tgaccagcct gaacagtatc tgtcacggac 1412521 ggtgaaaagc gaaacactgc ggcaggagct cctgaagtta aaagatcagc atcaatccgt 1412581 tttgatttta agagaattcc aagagctttc ttatgaagaa atcgctgaga tattaggatg 1412641 gagtctttct aaggtgaata ccacattgca ccgggctaga ttagagctaa agaaaaacat 1412701 gacgaaaagt agagaggagg agcggatatg acctgctttc tagtaagaga cctgcttcct 1412761 ctgtatcttg aaggtgattg taaaagagaa acggaacacg ttatagaaga gcatttaaaa 1412821 atgtgcagca gctgcagaga catgtatgac acgatggctg agccatttga attggaaagc 1412881 gaacaggccg ttgaggaggc ttatctgccg gaagaagaac tgcgttttaa acagaggtac 1412941 tatggattac tgatcatgaa agctgcctgc tggtttggag cggcggttgc catgatgctg 1413001 atcatcaaac tgctgatata aaaaaagcgc ttgtccgatt ccggcaagcg cttttttaca 1413061 ttaagcctgg ggatgaatca tatcgtaaat agcggcaagc tgttcttgtg acagggcact 1413121 gaagagtttt tcataaacgt cagcttgcag tggcgttgca cctgcttgta gcgctgcgtc 1413181 tttatcatag ctgtacacat catcttgtag cacaatggct gcttgaagaa tgtgaatctt 1413241 gagagaaaca gcggagaaaa attgttcaag tgcaagtgct tctttttctg tgaagccaag 1413301 ttcaactgct ttttctgtat caaatttgta atttccatcc tcgagataca cacattgtga 1413361 aacaatgctg aaaaattctg atgtcgattc ccagagtgta gcaattacct gagcctcttc 1413421 ttttgtcatt cctaactcga cagctttttc gctgtcaaaa taatatacac cgtcttgttc 1413481 gtatatacat tgatttaata tatcaatgaa tgtattgaga tcttcgttag tgctcgcctg 1413541 atgctggagt tgaacagcag tgttatcaac cggtgttttt gcgctggctg catcaggacc 1413601 gaacgttaat agagcagctg aggtcattgc ggcagtcgtt aacatagctt tttttacaaa 1413661 tgttttcttc atgtttcttc tctccctttt atgaattgtg ctacaaattc cattataggg 1413721 agtagtttcc ggtggaggaa taggcgctat ggtattttat gtgtatcgtt gccgaactac 1413781 tttttgaagg ctgcacgtgt gatcgttaga acgattgtct atgtatgaag gctgttttgc 1413841 atcttcctga ctaagaaaca ggggagataa ggcttaaaga aatgaaaaac accgctttct 1413901 ttgcggtgtt ttttgattac aatgtcgccg gcggggcaat gcttttaatc aagcaagcct 1413961 tgttcgcgca ttttcttttt taatgtaaat ccgccgccca tgacagcgca aacaagtaca 1414021 atgctggcga taatgcctgc agggcttttt tcagcgataa agacgccgat cagcataatg 1414081 ctgaaaaccg ctgcaaatgc aaataatagt aaaagccaat tcattttttt cataaattcc 1414141 atcccctttt acgtcttata ttaagtttac agaaaaacgt gacgctttta aagaggatgt 1414201 gtgatataat atgaaagtta tctaattttt ttaggagatg aaaaagtgaa acttcgaaat 1414261 gatcttcgca acatcgcgat tattgcccac gttgaccatg ggaaaacgac tctagtcgat 1414321 cagcttttac atcaggctgg tacgttccgt gccaacgaac aggttgctga acgcgcaatg 1414381 gactctaatg atcttgaacg cgaacgcggc attacaatat tggcgaaaaa tactgcgatt 1414441 aactataaag atacacgtat caatattttg gacacccctg gacatgcaga ctttggggga 1414501 gaagtagaac ggattatgaa aatggttgac ggcgtagtgc ttgtcgttga cgcatatgaa 1414561 ggctgtatgc ctcaaactcg ttttgttctg aaaaaagctc ttgagcaaaa cctgaaccct 1414621 gttgttgttg taaacaaaat tgaccgtgac tttgctcgtc cagaggaagt tatcgatgaa 1414681 gttctggatc tgttcattga gcttgatgcc aatgaagagc agctcgagtt cccagtggta 1414741 tatgcttccg cgattaatgg aacagcgagt cttgatccga aacaacagga tgaaaacatg 1414801 gaagctttat atgaaaccat tattaagcat gttccggcac ctgttgataa tgcagaggag 1414861 ccgcttcaat tccaagttgc ccttcttgac tacaacgact atgtaggccg tatcggaatc 1414921 ggacgcgtat tccgcggcac aatgaaagtc ggacagcagg tttctcttat gaagcttgac 1414981 ggaacggcaa agtcattccg tgttacaaag atttttggtt tccaaggctt aaagcgtgtg 1415041 gaaattgaag aagcaaaagc gggagacctc gttgcggttt ccgggatgga agatatcaac 1415101 gttggtgaaa cggtatgtcc tgtagaccat caagatccgc ttccggtcct tcgcattgat 1415161 gagccgacac ttcaaatgac atttgtcgtg aataacagtc cgtttgcagg ccgtgaaggc 1415221 aaatatgtaa cggcccgcaa aatcgaagag cgtcttcaat cacagcttca gacggatgtg 1415281 agcttgcgtg ttgagccaac agcttctcct gatgcttggg ttgtttcagg acgcggtgag 1415341 ctgcacttgt caattttaat tgaaaatatg cgtcgtgagg gctatgagct tcaagtgtca 1415401 aaacctgaag ttattatcaa agaaatcgac ggcgtacgct gtgagcctgt tgaacgtgtg 1415461 caaattgatg ttcctgaaga gcatactggc tctgtaatgg aatcaatggg tgcccgcaaa 1415521 ggcgaaatgg ttgatatgat caacaacgga aacggccaag tccgtctcat ctttacagtt 1415581 ccttcccgcg gattgatcgg ttactctaca gaattcctat cattaacacg cggattcggt 1415641 attttgaacc atacgtttga cagctaccag ccgatgcagg caggccaagt cggcggacgc 1415701 cgtcaaggtg tacttgtgtc aatggaaaac ggaaaagcaa catcatacgg tattcaagga 1415761 attgaagacc gcggtgtcat cttcgttgag ccgggtactg aagtatacga aggaatgatc 1415821 gttggagagc ataaccgtga caacgacctt gttgttaacg tcagcaaaat gaaacagcaa 1415881 acaaacgtcc gttctgcgac aaaggatcag acaactacaa ttaaaaaagc gcgcatcatg 1415941 tctcttgagg agtctctaga gtacttaaac gaagatgaat attgtgaagt aacacctgaa 1416001 tccatccgtt taagaaagaa gatcctcaat aagaacgaac gtgaaaaagc agctaaaaag 1416061 aaaaaaacag caggattgtc ttaatctcgt gcagaatttg aaaagataga acccgtacgt 1416121 ttacagggga gggaatcttt ttgaatgacg taagcgaacg cctgtcgttc ttcgccgctc 1416181 tatatcaagt agaccggcag cctgcggcag gcatgtggct gctgtacggc acgatttttg 1416241 tgttggccgt tattgtattt aagcttggat ttgctaaacg gcttcctgta ttaaaatctg 1416301 cagtggtgta tgtatttttg gctttgggct gcactgtttt gactttttta ggggtgtttt 1416361 tgcccgtggc agaaggattg gtcgtcgctg cgctgatttt aatcatttac aaaatccggc 1416421 tgtatcagtc gaaaaaagga cagtctgcaa aatcataaaa gactcagctg aaagctgagt 1416481 cttttttgtg ttctgtatgg ttaagcggcc gctttatttt ttgacttttt cttttttctg 1416541 ctgtcccggg tgaaaagtaa attttcccgt tttcagccgt tcctctgttt ttttggcaat 1416601 ccgatcgtgg cattcctggc acatatatgt atggatcggg cggtttcgaa gccgtttcgc 1416661 gatcagggta tcatcatcaa ttgtttcaat tttatcgcaa atagaacatt tgaccctcat 1416721 catatcacct ctttcactaa catgtattat accacggatc agaagctgtc caaaataaga 1416781 aaaagctaaa gcgcaaggct atagcttagt cattgttgtt ctttttcata tgatgatcag 1416841 attgatcgtt ttgttccttc tccatttcct gttgctgttt tctatttaat tggtcatttt 1416901 gctgctttgt ttgcggttca tcttcattgt caatcacatc gttaggcact tcgggaagca 1416961 ctcggccgac aattgcagct aattcatcca gtatacctgt taccggatgg ccctcgctga 1417021 tttctctgct catttcgcga aggcggctga ccgtatcggg atcagcaatg actactgcgt 1417081 tggcgccata tcgatcattc tttagcgcct gagctacaga atatttaatg gtttccactt 1417141 tgcttctgtc caaagtatca tcgacatcaa tcccaacaac agcatagcct cccagcacaa 1417201 cggctgttgc atccttgacg tcggggtttt tttcagcaac gctgacaaga tgcttggcaa 1417261 tatccgttct tgttccattg tcttttgttt cttgagttgt gtcctttacg tgaatcggtt 1417321 tagtctcctg ctgtcttgtt gattcttttt caacattctg gccctgtttt ccttgttgat 1417381 aggcacaagc ggacaggata agtgtcagct gtatgataat gaaaagaatt cgcacttgcg 1417441 ggttccctcc ttaaaatgct ttcattaatt ttattgttga attaaccttc tatctttatg 1417501 cacaaaaaca tatattttag caggcattca cctttttcat caaaagagaa gcaggaagaa 1417561 ctttgaccct tatatcagga ggctgagact tgagtaaaat ttatgtgtta gatacgaatg 1417621 tgttattaca ggatcctaac gcgatatttt cttttgaaga aaatgaggtt gtcatccctg 1417681 ctgtcgtttt agaagaggtt gattcaaaaa aacggtatat ggacgaagtt gggaggaatg 1417741 caaggcacgt atctaagcta atcgatgcgc taagacaaaa gggcaggctg catgagcatg 1417801 taccgcttga caccggcggc acactgagaa ttgaactgaa tcatcgttcg tttcaccagc 1417861 tgcaagagat ctttattgaa aagacgaacg ataatcgcat attagccgtt gcgaaaaact 1417921 taagcctcga ggaagaaacc aaggaaaatg gcaggccggt tatccttgtc agtaaggatg 1417981 tactggtcag ggttaaagcc gacgcaatcg gactgcttgc tgaagatttc ttgaatgacc 1418041 gggttgtgga caatgatgaa atgtacagcg gctataaaga tttatatatc agccagcagc 1418101 tgttcagctc tttttacggg aaaaatcaaa tttcagtaaa cgatgtgaaa cagcatgcgt 1418161 tttatccgaa tcagtttgct ttaatgaagg atgagctagg agggtcctcc tcggcagtcg 1418221 gaattgcaga caaaaccgga acggtattaa aaagactcgt atttgatgat gaacatatat 1418281 ggggaatcag gccgaaaaat gtacagcaga caatggcatt agagcttttg ctgcgggaag 1418341 atattccgct tgtcaccctg atcggcaaag cgggaaccgg caaaacgctc ttagctttgg 1418401 cggcagggct attacagaca gaagacttgg gaatatataa aaagctggtc gtcgcaaggc 1418461 cgattgttcc tgttggcaag gacatcgggt atttgccagg cgaaaaagag gaaaagctaa 1418521 agccttggat gcagccgatt tttgacaact tagagtttct gtttaatgcg aaaaaaccag 1418581 gggagcttga tgctattttg gcgggaattg gctcaattca ggtagaggcg ctgacttata 1418641 tcagagggag aagcattcca gatcaattta ttatcattga tgaagcgcaa aatttgacca 1418701 ggcatgaggt gaaaacgttg ctgacgagag tcggtgaggg cagtaaaatt gtcttaatgg 1418761 gcgaccctga acaaattgat cacccatatt tagacagtct gaacaatggt ttggcctatg 1418821 tggttgagcg gtttaaagga caacccatct caggcagcgt gaagctgtta aaaggtgaga 1418881 gatcaggtct cgcccagctt gcagctgatt tgctgtaaca cttaaatgat ttcgatctct 1418941 tttacatcgg taatcggctg tttgtgatga accgggtctt caaagtaaat atgcacgggg 1419001 ccgccttctt gaatcggctt gcctgcctca ctgaaatgga caatactgtt cagagcggtt 1419061 tccagagaaa cggcggcctt tcccgaactt gtgacaaata cacattgtgt cgcagagctg 1419121 ttcggctcag catttttcag gacagtccca agtctcattg cgaaactgcc gttcatcagt 1419181 ttttgcttct catattgctt ttccgtcttt aatgtaggcg gcgcgattcg cccctctctg 1419241 atgacgcgtt ccggatcaag gtcggattca tccccggctg attgtaaata tgtgtcttga 1419301 ctgtcccctt tgcggtcaaa cgaaaatttg cgatcatcaa aaatccatac gcttggatca 1419361 atggtaattg gatatgtaac attgcctttt acttggataa cgctcatgat atgaccccct 1419421 tctctcaaaa ttataaaagt tttcgcatga attgtcactt tgtgtacaaa ttatgtgtat 1419481 tgaaatgctg agggaacgag ggtgtttgca tggtatgcca gcataatgat gagcttgaag 1419541 ccttagtgaa aaaggcgaaa aaagtaacgg acaaggggga ggtagccagc tatattcccg 1419601 ccttggcaaa agctgataaa cacgacctgt cagtggcgat ttattattcc aataatgttt 1419661 gtctgtcagc aggtgacgta gaaaaaacat ttacgcttca aagtatatcg aaagtccttt 1419721 cccttgcttt ggtgttaatg gaatacggca aagataaggt cttcagttat gttggacagg 1419781 agccgaccgg tgatccgttt aattcaatta tcaagctcga aacagtgaat ccgagcaagc 1419841 cgttaaaccc tatgattaat gccggggcat tggtagtgac aagtctgata aggggaagaa 1419901 cggtaaaaga gagacttgat tatttgcttt cttttatcag aaggctgaca aacaaccaag 1419961 agattacata ctgccgggaa gtggctgaat ctgaatacag cacttcaatg attaatcggg 1420021 cgatgtgtta ttatatgaag cagtacggca tttttgaaga tgatgtagag gcagtaatgg 1420081 atttatatac gaagcaatgc gcgattgaga tgaacagctt ggatttagcg aaaatcggat 1420141 ctgtattcgc attgaacggc agacatccag agactgggga gcaggtcatc tcaaaagatg 1420201 tcgctagaat ttgcaaaacg tttatggtga cgtgcggaat gtacaatgca agcggggaat 1420261 tcgcaattaa ggtcggaatt cctgcgaaaa gcggcgtatc cggcgggata atgggcattt 1420321 cgccttacga tttcgggatc ggcatattcg gccccgcatt agacgaaaaa gggaacagca 1420381 ttgcaggtgt aaagcttttg gaaataatgt ctgagatgta caggctgagt attttttaat 1420441 ttatgtcata tgcttaaatc ctcttgcatt ttctgttgat accctttatg ataaatagaa 1420501 gaattaggta ctcgcctggg gaacggaggg atacttttgg cttcagagat gatagttgac 1420561 catcggcaaa aagcttttga actcttaaaa gtggacgctg agaagatttt gaagctgatc 1420621 cgagtacaaa tggataactt aacgatgcct caatgtcctc tatatgaaga ggttttagat 1420681 actcaaatgt tcgggctttc gagggaaatc gattttgctg tccgcctggg attggttgat 1420741 gaaaaagacg gtaaagacct tttatacaca ttggagcgcg aattgtctgc tttgcatgac 1420801 gcgtttacag ctaaataaat gataaaactc aaacttatta acagtttggg tttttttata 1420861 accgctattt ttctctcatc tcataaaaga cggtcttttt ttacacattc cttccgaatc 1420921 gtatagagat tcttcgtctc gtttgataaa ttgtagtaaa ataaaaaaga taaatacata 1420981 aaaaccatag ataatggaag ttagaagcag ggaagaggat gttatgttaa aaaaaatgct 1421041 aaaatcttat gattactcac tgatattcgc aatcgtttta ttatgcggat tcggtttagt 1421101 gatggtatac agctcaagca tgattacggc tgtctcccgg tatggagtaa gcagtaattt 1421161 tttcttcatg cggcagctgt ttgctttaat tgcgggtggc gctctattta ttctcatggc 1421221 gttgtttcct tataaagcac tggcccatca aaagtttcag aaggggatac tgcttgtatc 1421281 tgttcttgcg cttatctcac tgtttgtttt cgggcatgtt gccggaaacg cgcagagctg 1421341 gtttaaaatc ggcggaatga gtattcagcc gggggagttt gtgaaactgg tcgtgatttt 1421401 ataccttgca gccgtatatg caaaaaaaca aagttatatc gaccatctgt taacgggagt 1421461 agcccctccg gtagtcatga cgcttataat ttgtgggtta attgccatgc agccagattt 1421521 cggtacagcc atgattatag ggttaattgc gacgtgcatg atcttgtgct ccggcttcag 1421581 cggaaagacg ctggtgaggc ttgtgatact gggcggaatt gttttcattt tagtcagccc 1421641 tattatctat ttgaatcagg acaaaatttt aactgaaggc cgtttagcgc gttttgagag 1421701 tcttgaagac ccatttaagt atgcaaattc atcaggtttg caagtgatca attcttatta 1421761 tgcgatcagc tcaggcggca ttttcggcct ggggctcggt gaaagtatcc aaaaatacgg 1421821 atatctgcct gaatcacaca ctgactttat tatggctgtc attgctgaag agctcggcat 1421881 ttttggggta ttgtttgtga ttttcttatt gggttttgtc gtcataaaag gtttttatat 1421941 tgccagaaaa tgcgaggacc cgtttggaag tcttctggcg atcggcattt caagcatgat 1422001 tgccatccag tcgtttatta accttggcgg tgtcagcgga ttaattccga ttacaggggt 1422061 tacgctgcca tttatcagtt acgggggctc ttctttggtg ctgctgctgg ggagtatggg 1422121 gatattagcg aatatcagca tgtttgtgaa atattcagag aataagaaaa agaaagagcc 1422181 cttggcgccg aagggaatga aaaagaaaca gctcaaaaaa actgtttatc tgtaaaaaac 1422241 aagtgtgtac aggggaagga tattccgcta tgatagatta tattccattc gggtaagggg 1422301 gagaaaagtt tgtctcagca atcgatacaa aaagtattag tagcaaacag gggagaaatt 1422361 gcaatccgaa tattccgggc gtgtaccgag ttgaatattc gtacagttgc ggtctattca 1422421 aaagaagatt ccggttccta ccatcggtac aaagcggatg aagcatactt ggtcggtgaa 1422481 gggaaaaaac cgattgatgc ttacctggat attgaaggta tcattgatat tgcgaaaaga 1422541 aacaaagtcg atgcaattca tccgggatac ggtttcttat ctgaaaatat tcattttgcg 1422601 agacgatgtg aagaagaagg catcgtattc atagggccaa aatccgagca tctcgatatg 1422661 tttggtgaca aggtaaaagc gcgtgagcag gcagaaaaag cgggaatccc cgtgattccg 1422721 ggaagcgacg gtcctgccga aacgcttgaa gccgtcgaac aatttggaca agctaacggt 1422781 tatccgatca tcattaaagc ctcgcttggc ggcggcggcc gcggtatgcg gattgtcaga 1422841 tctgaaagtg aagttaaaga agcatatgag cgtgctaaat cagaggcgaa agcagccttt 1422901 ggcaatgatg aagtttatgt agaaaaatta attgagaatc cgaaacatat tgaggttcag 1422961 gtcattggag acaagcaggg caatgtcgtc catctttttg agagggattg ctccgttcaa 1423021 agacgccatc aaaaagtcat tgaagtggcg ccgagtgtct cgctgtcacc tgaattaagg 1423081 gaccaaattt gtgaggctgc agttgcgctt gccaaaaatg taaactatat aaatgcgggg 1423141 acggtcgaat tccttgttgc aaacaacgag ttctacttta ttgaagtaaa tcctcgcgta 1423201 caagttgaac acacgataac agaaatgatt actggtgtcg atattgttca aactcagatc 1423261 cttgttgccc aagggcacag ccttcacagc aaaaaagtaa atattcctga gcaaaaggac 1423321 atttttacaa tcggctatgc cattcagtca cgggttacga ctgaggatcc gcaaaatgat 1423381 ttcatgcctg atacaggaaa aatcatggct taccgctcag gcggcggttt tggtgtccgt 1423441 cttgataccg gaaacagctt ccagggcgcc gtgatcacac catactatga ttcacttctc 1423501 gttaagcttt caacttgggc tttaacgttt gaacaggcag ctgccaaaat ggtgcgaaac 1423561 cttcaggagt ttagaatcag aggcataaaa acgaacattc cgttccttga gaacgttgca 1423621 aagcatgaga agttcctgac agggcaatat gatacatctt tcattgatac aacgcctgaa 1423681 ttatttaatt tccctaaaca aaaagaccgc ggaacgaaaa tgctcactta catcggcaat 1423741 gtgacagtga acggcttccc tggaatcggg aaaaaagaaa aaccggcgtt tgacaaaccg 1423801 ttaggcgtaa aggtagacgt tgatcagcag cctgccagag gaacaaagca aattctcgat 1423861 gaaaaaggtg cagaagggct tgcaaattgg gttaaggagc agaaatctgt ccttttaact 1423921 gatacgacat tcagggatgc ccaccaatcg ttattggcaa ctagaatcag atcgcatgat 1423981 ttgaaaaaaa tcgcaaatcc gacggctgcg ttatggcctg aactattcag tatggaaatg 1424041 tggggaggcg cgaccttcga tgtagcctac cgattcctga aagaagatcc gtggaaacgt 1424101 ttggaagatc ttcgcaaaga agtgccgaat accttattcc agatgttgct tcgctcatca 1424161 aatgcggtcg gctatacgaa ttatccggac aatgtgatta aagaatttgt gaagcaatca 1424221 gctcaatccg gtattgatgt gtttcgtatt ttcgacagct taaactgggt aaaagggatg 1424281 acgttagcca ttgatgctgt tagggatacc ggcaaagtgg cagaagctgc gatttgttat 1424341 acgggagata tccttgacaa gaaccggacg aagtacgacc ttgcatatta tacatcgatg 1424401 gcgaaggagc ttgaggcggc cggagcccat attctcggga ttaaagatat ggcagggctg 1424461 ttaaaaccgc aggctgcata tgagctcgtt tctgcgttga aagaaacgat cgacattccg 1424521 gttcaccttc atacgcatga tacgagcgga aacggtattt atatgtatgc gaaagctgtt 1424581 gaagccggcg ttgatatcat agacgtggcg gtcagctcaa tggcgggatt aacgtcacag 1424641 cctagcgcga gcggatttta tcatgcgatg gaaggcaacg accgccgtcc ggaaatgaat 1424701 gtccaaggcg ttgaattgct gtcccaatat tgggagtcgg tgcgtaaata ttatagtgaa 1424761 tttgaaagcg gaatgaagtc tccgcatact gaaatttatg aacacgaaat gccagggggc 1424821 caatacagca acctgcagca gcaagccaag ggagtaggcc ttggcgaccg ctggaacgaa 1424881 gtcaaggaaa tgtacagacg cgtgaacgat atgttcggtg acatcgtcaa ggtaacgcct 1424941 tcctcaaaag tagtcggaga tatggcactc tacatggtgc aaaacaatct gactgaaaaa 1425001 gacgtttacg aaaaaggtga atctttagat ttccctgatt ctgtcgtgga gctttttaaa 1425061 ggaaatatcg gccagcctca tggcggattc ccagaaaaac tgcaaaagct gatcttaaaa 1425121 gggcaggagc cgattacagt cagaccgggc gaactgcttg agccggtgtc atttgaagcg 1425181 atcaaacagg aatttaaaga gcagcataac ttggaaattt cagatcagga tgctgtggca 1425241 tatgcccttt atcctaaagt cttcactgat tatgtgaaaa cgacagaaag ctatggagac 1425301 atctcggtat tagatacacc gacattcttc tacggtatga cattaggtga agagatagaa 1425361 gttgaaattg agcgcggcaa aacgctgatc gttaagctga tttcaatcgg tgagcctcag 1425421 cctgatgcca cccgcgtcgt ttatttcgaa ctcaacgggc agccgcgtga agtagtcatt 1425481 aaagatgaaa gcattaagtc ttccgttcag gaaaggctga aagcagaccg gacaaatcca 1425541 agccacatcg cagcttccat gcctggaaca gttattaagg tattggctga agcaggcaca 1425601 aaagtcaata aaggtgatca tttgatgatt aatgaagcga tgaaaatgga aacaacggtt 1425661 caggcgcctt tctcaggaac aatcaagcag gttcatgtga aaaatggtga gccgatccaa 1425721 acgggagatc tgctccttga aattgaaaaa gcataaaaaa caaagagtgt atatcaatga 1425781 tatacactct tgttttttat atagaaaatg tggagtgaaa cagatggtta gaagagatat 1425841 aaggggactt cagagattat agagtactgt cacaagccca aaataaaaag aggcttatac 1425901 agccaatatt ttagatgctt tgtagtatgc cgtgcatatt tctttaagca ctatctgatt 1425961 taaaaggctt taatacttat gttcgcgagc tatagatcca tatgaaattt ctataatcac 1426021 gatgagaaag gggacagacc gaagtgagcc gctcactgat catcaagttc ggcgaaggct 1426081 ggcgattgaa acgcataaag cgccaaaaaa caagacataa aaaagaccaa agccgcctaa 1426141 ggctttggtc ttgagtcctt atgattgcct ggattcataa cggaaacgag caatcaataa 1426201 taagaagtag catagaacgc caaacagaca ggcaataaag aacgagtggg caagtgcaaa 1426261 gcccagagcc agttcagagt atacgatcat aataccggac agtgcctgta atgtaatgaa 1426321 aataagacat gagatccatc cccaaaagat ctgtttttga tctttatagg aagtaatagc 1426381 atgaacagcg gcaacaataa tccatacaaa taaaagtaag gctgctgctc tgtggcccat 1426441 ttgcacccat tcatggaatt gggtcggaag tccattgttc agcgggctgc acagcggcac 1426501 attaggacat gccagacttg attcagtgtg tcttacatat gcgcctgtat acacaacgat 1426561 ataggaatat attaaaattc ctatcatgtg aaattgcatc tttttgccga tttgaagcgg 1426621 cttaaccagt gttctgactg atttatcagc ttcaaatatg agcaatgtta aaataagcac 1426681 tgaagcaaaa gaaattaatg agatgccgaa gtgaagcgcc ataatcagcg cgttcgaacc 1426741 gaatacgaca gccaatgcgc caagcaatgc ctgaagaaat aaaaagataa ttgacatgat 1426801 cgcgagaaac gttgtttcac gaaaaatcgg cgtgattttt ctccatgacc aaaacgcaag 1426861 gcttagcaca aggataatag agattccgct tgcgaatcgg tggctccatt caataattga 1426921 agccggattc agttcaggga aaaaacggcc gtgacacagc ggccactgtc tgccgcatcc 1426981 ttggccggaa cctgtttttg taacgagggc acccccgatt aaaacaatta gcatgacaaa 1427041 tgtcgtcaga acaccgagag cttttaatgc tttattcata caatattcac cttcttaaca 1427101 tactgctgca attttatata cgttccaagt gtaagcgaat atgtgttttg tggcaattcc 1427161 cagagccttt tgttcacaaa aatataatag aatgacggct tctggaaaat gtacacttga 1427221 ttattcatgc cgggtctgat agaaataagg taaacgcaat gccgatttgg agattgcctt 1427281 catctttggt aaaattcata aaaagttcac aaataaattc ctgtttgtcg tttaatattt 1427341 aataggatgt ttttttacaa gatgttatct tgtatgatag agttgcaggt tattttattc 1427401 tcctgcgtta ggtttgtaag ggaggtttac gttatggcta actccagaat cttaaatgat 1427461 acagctatag acggacaaat tgaagaaaca acggcatgga aagattttct gtcccttatt 1427521 aaaataggga tcgtcaattc taacctcatc acgactttca ctggaatgtg gcttgcactg 1427581 catatatccg gtttaagttt tttaggcaat ataaacaccg ttcttcttac gttaatcggg 1427641 tcttcactga ttattgcggg ctcctgcgcg atcaataact ggtatgaccg ggacattgac 1427701 catcttatgg agcgtacgaa agtaagaccg acggttacgg gtaaaattca gccgagtcag 1427761 gcgttatggt ctggaatttt gctggttgct ttaggattga tcatgctgct gatgacaact 1427821 gtcatggctg ctgttatcgg ttttatcgga gtctttacgt atgttgtatt gtacacaatg 1427881 tggacgaaac gccgctatac gattaacaca gtagtaggaa gcgtttccgg tgcagtgccg 1427941 ccgcttattg gatggacggc agtggaaggg aatatcggtg tcgtagcatg ggtgttattc 1428001 atgattttat ttatttggca gattcctcac ttcttagcat tggctattaa gaaaactgag 1428061 gattacagag ctgcaaatat tccgatgctt cctgtcgtat acggatttga agtgacaaaa 1428121 agacaaatta ttgtgtgggt tgcgtgcctg atgccgcttc cgtttttcct tggtagcctg 1428181 ggtcttccga ttgtcattct cggcttgctg ttaaatatcg gctggctgat tcttggctta 1428241 atgggattcc gctccaagaa tatcatgaag tgggcaacgc agatgttcgt ttactcgctt 1428301 aactacatga caatctattt cgttgccatg gttgtcttga cgcttttcta aaaaatagat 1428361 atgatgcttg ttttatcgct tcaaaataaa cgatgacaac tagtaaatgc cgccttgacc 1428421 tcttgtttaa tcaggcggct ttacttttat acatagatgg cattttgagt aaaaaaactc 1428481 ataatttaag agaagaggaa atgtaagtgc tttattggtg ataggttgga tggcgataga 1428541 tttcgatccg ctttccgcct ttgtattgac cagaaaaggg gttgggtgaa atggtaaagc 1428601 attggcgtct tattttatta ttagccttag tgccgcttct attaagcgga tgtggaaaac 1428661 cttttttatc cacgctcaag cctgctggcg aggtggctga taaacagtat gacctgacag 1428721 tgctcagcac attgattatg gtggttgttg ttgcagtagt atctgttatc ttcttttatg 1428781 tgattgtgag attcagaaga tcacgggtcg gtgagaacac gataccgaaa caggtagagg 1428841 ggaataaatt tttagaaatc acatggaccg tgatcccgat tttgctgctc attattcttg 1428901 tgattcctgt tgtattatat acgctggagc tagcggacac atcaccaatg gataaaaaag 1428961 gccgcaaagc tgaggatgct cttgtagtca atgttagggc aaatttatac tggtgggagt 1429021 ttgagtaccc tgattacggc attatcacaa gccaggagct gattgtaccg acagatcagc 1429081 gtgtatattt taatttaaaa gcctctgatg taaaacattc cttctggatt ccttcagttg 1429141 gaggaaaact tgatacgaat acggataatg aaaataagtt cttcctgaca tttgattcaa 1429201 aacgaagcaa agaggcagga gatatgtttt ttgggaagtg tgcagagctt tgcggccctt 1429261 cacatgcgct gatggatttt aaggtgaaga cgatgtctgc aaaagaattt cagggctgga 1429321 caaaagaaat gaagaactat aagtctacag cagagagcga tttggctaag cagggtgaag 1429381 aactgtttaa agagaaaaac tgcctgagct gccatgcggt agagccgaat gataagcgtg 1429441 cagaagccgc tagaacggca cctaacttgg cgaccttcgg tgaaaggaca aaagtggcag 1429501 gggtgaaaga ggccaacaaa gaaaatgtga aggcttggct gaaggaccct gacagcataa 1429561 agccggggaa caaaatgaca ggcacatatc caaagctctc agacagcgaa acaaatgcgc 1429621 tttatgaata cttaaaaggc ttaaaagcgg aaagcaagta gggaagaaag ggagatattg 1429681 ggggaggtca catatgttga atgcgcttac agaaaagcgg acgcgcggat ctatgctttg 1429741 ggattatttg acgacggtgg accataaaaa aatcgcaatt ctttatttag tggcaggggg 1429801 attcttcttt cttgtcgggg gaattgaagc gatgtttatc agaattcagc ttgcaaagcc 1429861 ggaaaatgcg tttctcagtg ctcaagcgta caatgaagta atgactatgc acggaacgac 1429921 gatgatcttt ctggctgcga tgccgctctt atttgccttg atgaatgcgg ttgtgccttt 1429981 gcagatcggg gctcgggacg tttcgtttcc atttttaaac gcgcttggtt tttggctctt 1430041 ctttttcggg ggcattttct taaatctaag ctggtttttg ggcggagcgc cagatgcggg 1430101 ctggacatca tatgcctcac tttcgcttca ttctaaaggg cacggcatag actttttcgt 1430161 cctcggactc caaatatcgg ggctcgggac gctgatagcc gggattaact ttttggccac 1430221 gattatcaac atgagggctc cgggcatgac gtatatgagg ctgcctttgt ttacatggac 1430281 gacatttgtg gcctcggcat tgattttgtt cgcgtttccg ccgcttacgg ttggattggc 1430341 tctcatgatg ctggatcggc tgttcggaac caatttcttt aatccggagc ttggcggaaa 1430401 tacggtcatt tgggaacatt tattttggat cttcggccac ccggaggttt atatcctaat 1430461 tttgcctgca ttcggtattt tttctgaggt catccctgtg ttcgccagaa agcgtttgtt 1430521 tggctattct tcaatggttt ttgcaatcgt gctcattggc tttctgggct ttatggtttg 1430581 ggtgcaccac atgttcacga ctggtctcgg cccgattgca aatgcgattt ttgcggttgc 1430641 aacaatggct atcgcgattc cgaccgggat taagattttt aactggctgt tgacgatttg 1430701 gggaggaaat gtgaagtata caaccgctat gctgtatgct gtctcattta ttccatcctt 1430761 tgtgctcggc ggtgtgacgg gagtcatgct ggcagctgct gcggctgatt atcagtttca 1430821 tgatacgtat tttgtggttg cgcacttcca ctacgtcatt attggcggcg ttgtattcgg 1430881 ccttttagcc ggtgttcatt tctggtggcc gaaaatgttc ggtaaaattc tgcatgaaac 1430941 gatggggaaa atttcatttg tattgttttt tatcggcttt cacctcacgt ttttcattca 1431001 gcattttgtc ggcttaatgg ggatgccgcg ccgggtttat acgtttttgc caggacaggg 1431061 tctggaaacc ggcaacttga tcagtacaat cggggcgttt tttatggcgg cagctgttat 1431121 tcttctgctg gtcaatgtca tatggacatc ggtaaaaggt gaatatgtag gtgctgatcc 1431181 atggcatgac ggacgtacgc tggaatggac cgtttcttca ccgccgccgg agtataactt 1431241 taaacagctt ccttttgtca gaggacttga tccgctttgg atcgagaagc aggcagggca 1431301 caaatcaatg acgccggcgg aaccggttga tgatattcat atgccaaacg gctcaatcct 1431361 gccgctcatc atttccttcg gcctttttgt cgcagcgttc gggctgctgt acagaagtga 1431421 ttacgcttgg ggcctgccgg tgatctttat cgggctcggc atcacattta ttacgatgct 1431481 gcttcgttca gtaattgatg atcacggcta tcatattcat aaagaggaac tgccgaacga 1431541 tgataaaggg gtgaaggcat aatgcaagtt caagaaaaat tcaccgcaga aacctttcca 1431601 gcttctcctg aaaaagtaac cctggaaggg aaaaataaat ttttaggctt ttggcttttt 1431661 cttggcggag agactgttct gtttgcgtct ctcttcgcca cgtttcttgc gcttcggaat 1431721 tcaaatgccg gtgatccgcc tacgacggaa atgttcgatg tgacacttgt attcattgcc 1431781 acaatgcttc tattaacgag cagtttaacg agtgtgtacg cgatgtacca catgaagaac 1431841 ttttccttcg gcaagatgca gctttggctg ggaattacga ttttattggg ggcgggcttt 1431901 ttaggactgg aaatctatga gttcaagcat tacacccatg aatttggctt taccatcaca 1431961 agctctgccc ttggttctgc gttttacacg cttgtcggta cacacggcgc ccacgtggca 1432021 tttgggctta tgtggatcag cacgcttatg atccgcaatg ccaagagagg gctgaatctg 1432081 tatacggcgc ctaagtttta cgttgccagc ctttattggc actttattga tgtcgtgtgg 1432141 gtcttcatct ttaccgttgt atatttaatg gggatggtgg gataaacatg gtcgataaaa 1432201 aaagcagagg gcatatcaat agcgaccttg aatttaagaa aaaaaagcat gcccgggaga 1432261 tgaaatatca agtcctgtct tttggtttaa tgatcggtct tacgattgtt gcatttctga 1432321 ctgtggccac ggacggtgtc ggcagctggt ttacgattcc tttcattatt ttgctagctg 1432381 caattcaagt catttttcag ctgtattatt tcatgcatat gaatcagaaa gggcatgagg 1432441 cgccggcact gtttttgtat tcaggggtgt ttgtcgcgtt tatcactgtg cttgcgtttg 1432501 tgacaattat atggtggtaa tttgaacagc cgccggaggt gaagaaatga atcagttgga 1432561 gatatttggg tttcgcgcga tgtggagccc ttatcttttt tgtatcctgt taggcattac 1432621 ggcgctttat ctctattttt acaggcgaat gtcttcaaag ccgaatcgaa taactggtaa 1432681 agagatggtg tgctttctgt cggcgatgct gtttttatat gcagccgagg gaagcccggt 1432741 tgatctgctc ggacatatta tgttcagtgc gcatatggtg cagatggccg tcctgtattt 1432801 ggttgtcccg ccgctgttaa tcgcggggat tcctgcatgg ctctgggaaa aaatcatttt 1432861 caggccttca atcaaaccgg ttttttcctt ttttacgacg cctttaattg ctttgctttt 1432921 gtttaacggc attttttctt tatatcatgt accgcttata tttgatactg tcaaaacaga 1432981 tccgttttac catacattaa tcacttggct tatctttgtg cttgcgttct tcatgtggtg 1433041 gccgcttgtt cataaggttg agcgtctacg gcagctcagc ggcttgatga agctgggtta 1433101 tattatggcg gacggtatgc tgctcacacc tgcttgcgcc ttgatcatgt tcagcggtgc 1433161 accgttatac gccacctata cagatccggc tttatgggct gaggcaatga ggctttgcgt 1433221 gccagcggat atgatggggc aggtcccatt aacagggcca gagatgttga atacactgcc 1433281 tttgttagag gatcagcagc tcggagcagt catgatgaaa atcattcagg aaattgtgta 1433341 cggtactttt ttggccgtta tttttttcca atgggtgaag aaagaaaggg aaaaggacgg 1433401 gcaggaggag ccgccgtata ttcagcagac gatatcataa aaggtacagc gaaatatgct 1433461 gtaccttttc gttacatttg aactgttttt aacatgttgg ctatgtcctg aatcagtgcc 1433521 ttgctttttg tcacaacctg tacgggaaac tcttccgttt ctccatattc tactccatga 1433581 gggtagtaat gctttcctag gagaggggac attaattgaa tcacggcgcg cccgcttccg 1433641 acatcgcctt ctgccgcaat accttgtatc cgcaggtaaa acgtaccctc aatcgtcgaa 1433701 aacttcttgt cataggtgac tctctcgtaa tcccattgac ccgctctgat aagacctttg 1433761 ctttccatta agtcgtctag ccagctgagc tcagccttaa ccccttcaag tccgctttca 1433821 gtaaacttca acactgaccc ctccttataa aaattacctt tcctgacaat catagtatga 1433881 aagcgttaaa ctttcaatga atcttcttct tttgaaagta tgcaaaaatt aaattttgac 1433941 gacaatagca ctagactaaa ggaggttaaa cggatgacaa aaataaaaga tctgatgaca 1434001 gccgacttgc aatattgcac ggtattagat aatgtatatg aagctgcagt aaagatgaag 1434061 gacgcaaatg taggagcgat accggtagtt gatgaggacg gggaaacatt ggtcggcatc 1434121 gtaaccgacc gcgatctcgt attaagagga atcgccatca aaaaaccgaa ctcgcaaaaa 1434181 atcactgacg cgatgactga aaaacctgtc agtgtggagg aagatgcttc agtcgatgag 1434241 gttcttcatt tgatggcatc gcatcagctc agaaggatac cagttacaaa aaataaaaaa 1434301 ctgactggaa ttgtcacgct tggtgatctt tctttatctg agcaaacgaa tgaacgtgcc 1434361 ggcagcgcct tatcggatat ttccgaaggg gataatagag aagaaggctt ttttcattaa 1434421 cacataaatc tttgacatgt taaataggct gtattgtaat gggatgtaaa caagagattg 1434481 tgaatcgcca cgggggtgat agattgaaaa atatattgag agcaatggtt atccttttga 1434541 ttatctgcgg aacctatgtt ctgtttattc aatatggatc tgttcctgaa aagaaatcaa 1434601 atgacagcga gcctcaggtg tcgaatgagg aagcgcaaag cggcaaacga atacatatgc 1434661 cgacttcagg gttattgtcc ttcatgggca agcacgccga tgaagtaacg aaaaagcttg 1434721 gggaacctga acgtattgac ccttcggctt atgattacga ttggtgggta tacaatcaag 1434781 gtaaggatca atatatccaa atcggggtat taaacaataa agtggtcaca ttattcgcgt 1434841 cgggtaatga tattaacgcc aagcctttca aaattggaga atcaactggc gaagtattca 1434901 agaccaccca ggtggcacca tttgtgaatg tagagtataa aggaaattcc tatcggtttg 1434961 aattttctga agaagatatc aatacaagac cgactgtaaa ggtaggaaag atgtatgtcc 1435021 agctgtatat ggacaaattt gaggggaagc tatccagcat cagggcgttt gatgcgcaga 1435081 cctttgtaaa gcaaagacct tatgaggtag tgtaccgcgg ggaattaatt aaaccgaaag 1435141 ccgtttcaga tgagaaatgg aaaaagatcc aaacaacgag cgaaaagcaa atccttgatt 1435201 tgacgaatgt catacgcgtt aaacatggac ttgcgaagct tgagtgggat cagccaacgg 1435261 cggaagtggc atttgggcat agtgaggata tgaaggaaaa taattatttc tcccatgtct 1435321 ctaaaaaata cggctcgctg aaagaccgct tagaagaagg gcatgttgat tttcagcaag 1435381 cgggagaaaa tatcgcatac aattatgtgg acggtccggc tgctgtagaa ggctggctga 1435441 atagcgaagg ccatcgaaaa gcgcttctga attcagatta tacgcatctt ggtgtcggag 1435501 tagaccggaa atattacacc caaaacttta ttaagcgatg gtaatgaaag ccgcggacga 1435561 atggttcccg gctttttcta tttccataca agctggtctg aatgaatgtg ctgatagctt 1435621 acagataagg ccgtttccca tcccttcagt caggcttttt caccagtgta tagggatatc 1435681 gctaaaaatt catttgggaa tgaatatagg cgaacacaat gcccgacaaa acgatacatt 1435741 gtagtaggta acgattttcg gagggggtga ggattgtggc gaatcaacat gccaatcatt 1435801 caatcaatga ctttaaacaa ttcgtcaaaa agcatcccaa gctgataaaa gaagtgcgca 1435861 aagaacaaag aagctggcag gacgtatatg aaaattgggt cctcttcggg gagagcgacc 1435921 cgatttggga tccatatcgg gaaccggaag aagcttctga agctgtgcct gaaacaccgc 1435981 aaaaaaatga ttttgtctcg aaaatggtga cagcggtgaa aaagatggat gtcaatcaaa 1436041 tgaacgaaca aatcaataaa atgagccagt cgatctcatc gttgcaaagc cttcttaata 1436101 cattttccgg aagcggacag aagcattctc agccaggctc tggacagcat cctttttctt 1436161 ttcgaaagga ttaaaaaagg ggagctcata tgcgcaaaga ggttcaggaa tatattttag 1436221 caaacgaaga acggaaacga ttcatcagag aacagccgat atggtaccgc aggctttcaa 1436281 gaaaaccgga tgatctgtcc tcctttcagc ttgaaatgat gaatttttat gaaaaaacca 1436341 ttccgcatcg ggtgaatcag tttacgaacg ggattcaaat ggcgcaaatg atgatgcaaa 1436401 tgtttcaagc gatgcggaca aaagattaaa aggccccgaa gaagggtctt ttttcatgcg 1436461 gtcataaggt tttgttggcg gctgcggtta agcattttcc aattggctgg tttcatggta 1436521 aactaacaac tggaggtgca tgttatgtat gcgacgatgg aatccgtgcg gcttcaaagt 1436581 gaagctcagc agcttgccga gatgattctg cagtcggaga cggctgagaa ctaccgcaat 1436641 tgttacaagc gtctccagga agatgaagag gcaggtcgga ttattcgttc ttttatcaaa 1436701 ataaaagagc agtatgagga tgtacagcgt tttggcaaat atcatcctga ctatagagaa 1436761 atatcccgga aaatgaggga gatcaaacgt gagctggacc tgaacgataa ggtggctgac 1436821 ttcaagagag ctgaaaatga gctccagtcc attcttgatg aggtcagcgt tgagattggg 1436881 acagctgttt cggagcatgt gaaagttccg actgggaacc cttattttga cggtttgtct 1436941 tcatgcggag gcggctgcgg ttcaggcgga agctgcggat gtaaagtgtc ctgacgagac 1437001 tggccgtctc gtcttttaca tataagagaa aacaggcagg tgattgtatt ggagaatagg 1437061 cgccagggca tggttgtgta tctgcactcc ctaaagcaga gcaaaatgct gaggaagttc 1437121 gggaatgtgc actatgtatc aaaacgatta aaatatgtcg tactgtactg tgatatggac 1437181 caaattgaaa aaacaatgga caagattgcg tcttactcat ttgtgaaaaa agtggagcct 1437241 tcttataaac cgtttttaaa attggaattc gagtcaaagc ttgataaggc aaaagaatac 1437301 gattataaaa tcggcatata gctataaaaa aatccccgca ggcatctgcg gggtccttct 1437361 attccttaat atgttaagga gaaggcaaag ggagaggaga aaccggagga agaacttatg 1437421 gggaaacgta agtcttctcc gcggttggca acaacatcct ctagatgctg ttgcttatag 1437481 tatggacaag gatcatgctg cctatacacc tgtttatcaa gattagcgtt cattgtttgg 1437541 aagaatgctt tatgttaaga taggattgat ttttttctat gtacatagcg gcgtccggcc 1437601 gaataaagaa acaaaatagc ttttagaaaa agtggtgtgg aacatgagag taatttctgg 1437661 atcaaaaaaa ggccgttcac taaaggctgt agccggaaca tcaacaagac cgacaaccga 1437721 caaagtgaag gaatccattt tcaatatgat cggcccttat tttgacgggg gcaggggact 1437781 tgacttattc gcagggagcg gaggtcttgg aatcgaagcg ctttcacgcg ggtttgagca 1437841 ttgtatattc gttgaccgtg attttaaagc gattcaaacg gtaaaatcta atttgaaaac 1437901 gctggagctt acaaaacatg cacaggtata ccgcaatgat gcggaacgtg ctttgcacgc 1437961 tgctgctaaa agagaaaccg gctttcgcgg aatttttctc gatccgccgt ataaggaaca 1438021 aaagctgaaa gcacttttaa ctttgattga cgaatatcaa atgctggaag aagacggctt 1438081 tatcgtcgct gagcatgaca gagaggtcga gcttcccgaa accgtaggag atcttgtgat 1438141 gacaagaaaa gaaacctatg ggttaacagg tgtagcgatt tataaaaaga gggggtagtg 1438201 aggtggcgag tatagctgtc tgtcccggca gttttgatcc tgtgacctac gggcatctgg 1438261 acatcatcaa acgcggggcg catatttttg aacaagtgta tgtatgtgtg ctgaataatt 1438321 cttcaaaaaa gcctttgttc agtgtggaag aacggtgtga gcttctgaga gaagtcacaa 1438381 aagacattcc gaacataaca gttgaaacat cgcaaggcct gttaattgat tatgcaaaaa 1438441 gaaaaaatgc gaaagcgatt ttaagaggct tgagagctgt atctgatttt gaatacgaga 1438501 tgcaggggac atcagtaaac cgggtgcttg atgaatctat tgagacgttt tttatgatga 1438561 caaacaatca atattcgttt ctaagttcaa gcatcgtaaa agaagtggca agatacaacg 1438621 gctcggtatc agagtttgta ccgccggaag tagagttggc gcttcagcaa aaattcagac 1438681 aaggatgagg gttttgactc atcctttttt tgttccgttt gtcagtctgt aagaaaaaat 1438741 gataatgtac gtaaacagcg cgcatagtgt gacagcaggt ccgatctgca caagcagatt 1438801 ccagccgttt ataaaggcag ttgacatgtc actgctgtta agagatttaa atacatactg 1438861 atacggatca tgccatgctg tgtaaagagg tttccataaa agcatgacga agacagcggc 1438921 ataaacgccc tgcagcaaac gtgcgataaa gaatggttta aatctaatgt cggtttccga 1438981 taaaatacct gccacctgag cttgtacgga aaagccgcta aacccaagaa taaagctgac 1439041 gataatggct ttttgcagaa gagaaacatc tgtctcgctg acaagcttgc tgcctaatgt 1439101 aatttcaaac atccctgata aaagcggaat gtccaattga gtcggaagct gaaacaaagt 1439161 cagtgctcct tttgtgaaaa cagacaaaac atcagtcagc tggaccactg acaacagccg 1439221 attgaagaca gaaaataaaa taataaagcc gcctaccata agaagcgttt gaacagaaga 1439281 cgtcacggcg tcgcctaaaa ttttacctaa gggccgtttt tctgcaagtc tggcggtatg 1439341 aagagcgtgt aaagcatctt tgactgaagg gaaaggtatc gttttctttc ttctgagatg 1439401 ctgctcttcc ttgcggccat aggagcgcat tgttaaaccg acggcaagat tccccaaata 1439461 gtgtgcagaa gctaataaaa tgcctagtga tgcgttttga aagaaaccga cggcaacagc 1439521 gccgaaaata aagagcgggt ttgaagaatt ggtaaacgac gcgagccgtt ctgcctctac 1439581 tcttgaaatc tgattttcct gccgcagacg ggcagtgagt tttgcgcccg ctgggtttcc 1439641 tgatgccatt cccatagcaa gaacgaagcc gccgacaccc ggcacgcgaa agatcggccg 1439701 cataaaaggc tcaagcaaaa caccgacaaa ccgcacaatg ccaaagccga ttaagagttc 1439761 ggacagaata aaaaatggca gcaatgacgg aaacacaacc tcccaccaca tagacagccc 1439821 ggttttagag gcttcgaatg aggcctgtgg atgtgagatg acagtcgctg ttaaaaaaag 1439881 aaaaaacgag gcaatcaaaa gtgtattaat cttcgacaag ttcattctta cctccccgat 1439941 gctaaaaatg cccaatgaca tgtatatcat gataaaataa tgtatgatgt aaaacggcca 1440001 agcagtacct gtcctcttga ttctttgtac taatatacga gcataggggt tcagtttaga 1440061 ccatagaatt cggtatacag ggaattcagg caggaggtta acgctttggc caaacctaaa 1440121 atcgggttag cgttaggatc gggaggggcc agagggcttg ctcatctcgg tgtgctttcc 1440181 agtttacata agcaccaaat tgaagtggat atgattgcag gaagcagcat gggcgctttg 1440241 gtgggcagtt tttacgccgc cggacatgac gtggcaacga tgaaaaaagt agccaaagcc 1440301 tttaaacgaa ggctttatgc tgattatacg gtgccgaaac tcggtttttt aaaaggtgac 1440361 cgcgtcagac agcttgtgca tgcttataca ttcggaaaac cgattgaaga gctccaaatc 1440421 ccgctgggca ttgttgcgtg tgatctacag acgggagaaa agattgtgtt ccgaaaagga 1440481 tcagtgtcag atgcagtgag ggccagcatc agcatcccgg gtatctttat tccgcagcgg 1440541 ctggacggac gccttcttgt agacggcgcg gtcgtcgatc gaattccggt ttctgttgtg 1440601 aaagacatgg gagctgatat tatcatcgct tcggatgttt ccagggttcg aaaaactgaa 1440661 acagcagtgc atatttttga tgtgattatg caaagtatgg atatactgca aaatgaatta 1440721 gtgcggcatc aaacaattgc cgcagatatc atgattcgcc cttcccttga aacatacagc 1440781 tcaagctcgt ttgccaatat tgaagaaatg atatcggcag gcgaagaggc gacaaaccga 1440841 atgatcagca agataagaaa agaaatagag aattgggagg gctcataatt tgctacgtaa 1440901 aaaacatttt agctggatgc tcgtcatcct catactgatc gccgttttat catttataaa 1440961 acttccatac tatattacaa aaccgggaga agcgacagag cttgcttcat tgataaaagt 1441021 ggagggaggc tacccggaaa aaggaagtct gtccttaatg actgttaaag tgggaccggc 1441081 taatccattt acatatgtgt gggcaaagat gcacccttat tatgaaattg ttcctgatga 1441141 gagcattaag gaggaaggcg aatcagataa ggagtatatg aaaagacagc tccaaatgat 1441201 gaaaagctcg caagaaaatg cggttatagc cgcctatcaa aaggcaggaa aaaaagtcag 1441261 ctattccttt aacggcatat acgcaagctc agttgtagaa aacatgccgg caaaagggaa 1441321 aatagaagtc ggtgataaaa tcatcagcgc agacggcaaa aactatcagt ctgctgaaaa 1441381 gctgattgat tatatcagca gcaaaaaagc gggagataaa gtcacgttaa agatcgaaag 1441441 agaagaaaaa gaaaagcgtg tcacccttac gttaaaacaa tttcctgatg agccggatcg 1441501 ggcaggaatc ggagtttcgc tttatacaga cagaaacgtg aaggtagagc ctgatattga 1441561 ttttgaaatc gaaaatattg gcggcccgtc agcagggtta atgatgtccc ttgaaatcta 1441621 taatcagctg acaaaaccag acgaaacaaa aggctacgat attgcgggaa caggtacgat 1441681 tgatgttgac ggaaaagtag gcccgatcgg cggcattgat caaaaagtcg tcgccgcaga 1441741 caaagccgga aaagacattt tcttcgcgcc aaatcaaaac ggcgccagca attccgatta 1441801 taagaacgca gtaaaaacag caaaagatat tgattcaaat atgaagattg tgcctgttga 1441861 taccatgcag gatgcgattg attatttgaa taagctgaaa gcgaaaagca cctgattctc 1441921 aggtgctttt tctatacatt taaaaagtgt tgttcatctt cgtcatatcg aatcggtgca 1441981 tgtccgtatt cctgtaggtc aaactcagtt ctcagcggct cttctatcgg caggctgtaa 1442041 atcctgcttg cttttacgtc cagatcgaga gctggatggg agaaagagga cagtttgctg 1442101 acaagcggaa cagacagtgc ttttttcttt tcggataaat aagcctgtcc ttttttcgtc 1442161 atgccgagaa gcctgatata cggcgcctta tcgttgtcaa gcagcttttg catatcctgt 1442221 ttttttgttc tggttaaaat gtgtgtattc atccgctgga gccttgtcca cgtatagcgt 1442281 tttgttttca gcagttccat aaattcctga taggagctgg attttctgat cgaacgaata 1442341 attctgtgct ctaaaccttc ctccacctcg tatacttgct gtaattcccg tgccgttaca 1442401 gttgaaaggc tgtattttaa gtaagaaaag tagctttcag gtgtatgcca caatccgaaa 1442461 gatttgcggt aagctgctaa ttcacgtgca gatgcagcag ggagaaaacg aaggcaggct 1442521 tcgagattct ggccaatcat cgcttttcta atgcttgtgg cacttgctat atggttttcg 1442581 ccttcaggga gatcggcatc atgatagtcc gaagagattc gtgccgtagt ataaggtttc 1442641 ataggatatc ccccggttag aatcgaggtc acatactggt atcccaaaat gttatttggt 1442701 tttgacaagt caagtgcact ttcagtatgc aaaatggagc tgaaggcgat agccgccgct 1442761 gctgggtaac tggccccctt tttaagttct tctttaattc ggtcattcaa tatatgttta 1442821 tgctcatcaa taagctgtgc tgtttctaaa aaaggcttga tatccccatt ttcactcccg 1442881 aaaaacagcg cctcacattc aagttcgttc aggatggaaa cactgccgcg tgcaaaaatg 1442941 tctgcttttt gcacggcata aagataaggc agctcaatga caagatcaac tccgctttgc 1443001 agcgccattt ttgttcgggc ccattttgat acaacagcgg gttccccgcg ctgtaaaaaa 1443061 tgtccgctca tgaccgcgac agccgtgtca catccggttt gcagctttgc tgtttgggca 1443121 tgataaaggt gaccgttatg aaagggatta tattcaacca ccaatccgac agctttcata 1443181 ttttttccgc ctttcttgct atgtttaaaa acgtatggta catttgcaaa tgaaaactct 1443241 tacgccttat ttttgtttta agtgtatgca tagcatattc cgctgtcaac gatacttcaa 1443301 tggcagcatt atgctgtaaa gaaaaaatat tgacaaaaac aatcttaaaa gctataatca 1443361 tgtttgttgc tttcctgagg tgatacaaat gaaatggacg atttatcagc tgcatcaaat 1443421 gccaaaacaa agttttgagt ttgatgaaac agttgagtta aatgagctga caaagctgaa 1443481 ttctgacatt cgccgcattt ctcccgttcg ggtgaagggc agagcggata tcaaatccaa 1443541 acaggtttcg tttgatttta caatttcagg cgaaatgctt ttgccatgct caagaacact 1443601 cgttgatgtt ccgtatccat ttgaaatttc aacaaaagaa ctgtttatat ttcatcacac 1443661 ggatgatata gaagatgatg acgttcacat tgttgaggac gatactatcg acataactcc 1443721 gatcgtgaaa gaagaaattc ttttagaaat ccctatgcaa atcttttgtg aatctgaaca 1443781 agaaaaagga gctgctcctc aagaaggaaa ggattggcaa gtcatttcgg aagaagacaa 1443841 gaagaatcaa gttgatccga gacttgcagc ccttgaaaag ctcttaaaac aagatgatga 1443901 atcttaactc tttaaggagg tgggaataat ggctgtacct tttagaagaa cttctaaaat 1443961 gaagaaaaga ttgcgccgta cacatttcaa acttaatgta cctggtatga cagaatgtcc 1444021 gtcatgcgga gagatgaagt tgtctcaccg tgtatgcaaa gcatgcggat catacaacgg 1444081 caaagacata aatgtaaaaa gtaactaatg agaaaagcgc agggtgaaag ccctgcgctt 1444141 tttctttttc tcttcctgtc agcttgcgga aaatttgtga gtgcaaatag tctatctaat 1444201 ctattaccgg catatgtatg agataaataa gctgacatgg agggagattg aatttgacca 1444261 ttacaagaca agatgcttgg actcaggatg aggatttgct gctggcagaa gtggtgcttc 1444321 gtcatattcg agagggagga acacagcttt cagcctttga ggaggttgga agggcgctga 1444381 ccagaaccgc ggcagcctgt ggtttcaggt ggaactcgta tgtgagaaaa caataccagt 1444441 caggtataga gcttgcaaaa aagcaaagga aagaactgag aaagcaaatc ggcgttcatt 1444501 cggtcaatat gccgaattcc atgaagcaga ctgcctcggc atcgtcagaa ggaaaacgag 1444561 atttgtccat tcaggatgtc attcaatttc tcgaacaatt caaagaaaca ccgtctgcac 1444621 aagaatttca gcttgaaagg gaaaaattga aggagcaaat ccaatcgctg caaaaagagc 1444681 ttgaggattt gcggagtgaa aatcagacat tgcggaatca gctagagatg acagaagagg 1444741 attacaaggc actgatcgat atcatggatc gggccagaaa aatggttgtt tcgaaggaag 1444801 acggaagaat gaaaaaagcg gctcaagaaa cgtaaagaaa cgcctgaaat gaaccggccc 1444861 tatagtaaga ataggccggt tgttttgatt tctatgcaga ctctcccggt gtcatttcgc 1444921 gatccatatc aggatgccag atgagcgggt tttccccttt gtcccgcgcc atatcatact 1444981 taacagtttt aaagttcatt ttgttccaaa attccgctga tttcattctc ggatttgtcc 1445041 ggatcggcat tttgaatgat tttgcaaatt caaccaaggc tctcccgtat cccctgttct 1445101 ggtagcccgg aagaacctca agcttccaca gctccaaata atcctggcgg ttgtcaaaat 1445161 agggattcga tttgccgtta acttgataca gactcattcg tgctacaagt ttatcgccaa 1445221 aataaatccc gtaaaaaggc gaggtgctgt cattttcaat aatattatcc tgaagttctt 1445281 caagcattga aagctcctga atgccgtatt ctttgaattt cttgaattct tccagcgttt 1445341 tatagttgat aagcagacgt tctacctttg tcaaacaaat ctcccccttt gttgtttcta 1445401 catatattgt aaacgcttta tttaaaaaat ccaaatattt aaactttaat tttaagcaca 1445461 tgggatcttt gagaagtaat ttcttcttac ttctgctatg ataatacgta aatgctaaat 1445521 tgggtgtgac atcatgaaaa ttggaattat cggcggaggc tccgttggtc ttttatgcgc 1445581 ctattatttg tcactttatc acgacgtgac tgttgtgacg aggcggcaag aacaggctgc 1445641 ggccattcag tctgaaggaa tccggcttta taaaggcggg gaggaattca gggctgattg 1445701 cagtgcggac acgagtatca attcggactt tgacctgctt gtcgtgacag tgaagcagca 1445761 tcagcttcaa tctgtttttt cgtcgcttga acgaatcggg aagacgaata tattattttt 1445821 gcaaaacggc atggggcata tccacgacct aaaagactgg cacgttggcc attccattta 1445881 tgttggaatc gttgagcacg gagctgtaag aaaatcggat acagctgttg atcatacagg 1445941 cctaggtgcg ataaaatgga gcgcgttcga cgatgctgaa ccagaccggc tgaacatctt 1446001 gtttcagcat aaccattcgg attttccgat ttattatgag acggattggt accgtctgct 1446061 gacgggcaag ctgattgtaa atgcgtgtat taatccttta actgcgttat tgcaagtgaa 1446121 aaatggagaa ctgctgacaa cgccagctta tctggctttt atgaagctgg tatttcagga 1446181 ggcatgccgc attttaaaac ttgaaaatga agaaaaggct tgggagcggg ttcaggccgt 1446241 ttgtgggcaa acgaaagaga atcgttcatc aatgctggtt gacgtcattg gaggccggca 1446301 gacggaagct gacgccatta tcggatactt attgaaggaa gcaagtcttc aaggtcttga 1446361 tgccgtccac ctagagtttt tatatggcag catcaaagca ttggagcgaa atacaaacaa 1446421 agtcttttga gctttttcgg taacatgcta tactcatttc ggatcactaa ctatttattg 1446481 gagaaaggaa gttctagaag atgcagctaa ctgaactttc catcaaaaat cagaatgtgt 1446541 ttgtacagca ctatatagat ggcaaagaag aaatgtcttc tttttttgat tacagtattc 1446601 atcataagga catgtggcgc gaaagactgg aagacttatc ttcccggttt ttcgcaagag 1446661 aggaattggc ggcgtactta acctcttacc ataataaatt cggttcaagt gcgatgcagt 1446721 ctgctattga gaagctgaag gacccgtcaa gtgccgctgt agtcggcgga cagcaggcag 1446781 gacttttaac aggaccgctt tacaccatac ataaaatcat ttcaatcatt gttttagcaa 1446841 agcaacaaga aaaggaactg caagtgcctg tcataccaat cttctgggtg gctggagaag 1446901 accacgattt ggatgagatt aattttgttc acacatctga agagaatggg cctgtgaaaa 1446961 aaaagctgcc tcagtcttat tggaagaaat catcagcagc gagtacatcg cttgatcagg 1447021 aaaagtgtgc cgcgtggata gatgatgttt ttgccgcttt tgaagaaaca gaccatacga 1447081 atacacttct cgacaatgtg aaacgatgtt taagggaatc tgttacgttt actgacttct 1447141 ttgaactgct gatcgcggat ttgttccaag aagagggctt agttttatta aattctgggg 1447201 atccggggat taaaaagctg gaaacggcca tgttccaaaa gattcttcga gaaaatgatg 1447261 aactcgcccg ggctgtatca gatcagcagg ccttcatgcg tcaagcaggc tacaaaccga 1447321 ttatcgagtc cggaaaagag caggcgaatc tgttttatga atacgaagat gagcgttttt 1447381 taattgaaaa agataacggc cgatttgtca tcaaagagct tgatctagga tggacgaggg 1447441 atgaacttca tacacatatg gaagaacatc cagagcgttt cagcaacaat gttgtaacga 1447501 gaccgttaat gcaggaattt ctcattccga ctttagcatt tattgcaggg cctggggaaa 1447561 tcaattattg gggcgagctc aaacaggcat ttgcggtgat gggcttcaaa atgcctcctg 1447621 tcatgccaag gctgaacatt acgatacttg agcggcatat tgagaaaaaa ctggctgaac 1447681 ggaatatctc attacaagac gcgattgagc gcggaacgga gaatcaaaga gagacatact 1447741 tcgagcgcca gattccggaa gagtttacgg cggtgatgga tcaggcgaaa agccaaattg 1447801 aagcgattca caaaacggtc cggcaggagg cgttaaaggt tgatcaaagc ttggaacctt 1447861 tacttctgaa aaatgccgct tttattcagg atcagcttca attcttagag cgcacggtga 1447921 tgaagcgaat tgaagaaaaa gaaggctacg tcttgaagga ttatgaaaga attcaaaata 1447981 gcattaagcc gcttcttgcg ccgcaagaac ggatttggaa tatcatgtat tatttgaaca 1448041 ggtacggtcc aaaattcttc acgacattca agaatctgcc attttctttt caaaatcaac 1448101 atcaagttgt caaactttga aataaagttt taaagaaccc tgactagttc agggtttttt 1448161 tttatgggta aacagtgtaa aatgaagttg tggagcgaag tggtgaatag tggtgagtta 1448221 aggagagaaa gtggggcaag agatcatgtt tatgggtgaa tatcagcata ccatcgatgc 1448281 gaaaggccgc atgatcgtac ccgctaaatt cagagaaggc ctaggtgagc aatttgtgct 1448341 gactagagga cttgaccaat gtctcttcgg ctaccctatg cacgaatgga aacaaattga 1448401 agaaaaacta aaagctcttc ctctcacaaa gaaagatgcc cgcgcgttta cccgtttctt 1448461 cttttcaggg gcgactgaat gcgaactgga taagcaaggc agggtaaata tcgcatcatc 1448521 tctattgaat tacgccaaac tggaaaaaga atgtgttgtt atcggggttt ctaatcgaat 1448581 tgaattgtgg agtaaagtaa tttgggaaca atacacagaa gagcaagaag attcatttgc 1448641 tgaaattgct gaaaacatga ttgggtttga tatataatga ttcttcgtgt ataacactct 1448701 aaaaacaatt tcaattcatc ctgataaaag gtgggaccaa cacaatatgt ttcaacacaa 1448761 gacagtactt cttcgtgaaa ccgtagacgg acttaatatt aaaccagacg gtacatatgt 1448821 agactgcaca ctcggcggag ctgggcatag tacatactta ttgcagcagt tatccgagaa 1448881 ggggcgttta atcgcttttg accaagatga tacggcatta cagcatgcta aagaagtgtt 1448941 gtccgattat aaaggacagc tcattctgat taaaagcaat ttcaggtatt taaaagaata 1449001 tttgaatgaa caaggcgtta cagaagtaga cggcatttta tttgatttag gggtgtcctc 1449061 tccgcagctg gatacaccgg agcgcggatt cagttaccat catgacgcac cgttggacat 1449121 gaggatggac cagtcggcta cgctttcggc gaaagaagtc gttaatgagt ggcgctatga 1449181 ggatctcgtc cgtattttct ttaaatacgg agaagagaag ttcagtaaac agatcgccag 1449241 aaaaattgag gaggcaagaa tgaagtctcc tattcaaact acgggccaac tggtcgatct 1449301 aataaaagac gcgattcccg ctccagcgag aaggagcggg ggacatcccg ctaaacgcgt 1449361 gtttcaggca atcagaattg ccgtaaacga tgaacttagg gtgtttgaag aagctttgga 1449421 gcaggcaatt gaggttctga agccaggggg cagggtatcg gtcattacct tccactcgct 1449481 agaagacaga atttgcaaaa ccacttttaa agaaaagtcg tcgcttccgg aacttcctcc 1449541 gggacttcct gttataccgg aagagtttga accggagctg aagctcatca cacgaaaacc 1449601 gattacggca tctcaagaag agcttgaaga gaacaaccgg gctcgttctg ccaagcttcg 1449661 gattgctgaa aaaagaaaat aacgaaacgc gaacgcaaaa ttaaaaggag gtcatcagcc 1449721 tatgagcaat ttagcttacc aaccagagaa acagcagcgg catgcgatca gtcctgagaa 1449781 aaaagtgatt gtcaagaaaa gggcttccat tactctcgga gaaaaagtgc ttcttgtcct 1449841 ctttgctgcg gcggtgctca gcgtatcgct tttgatcgta tcgaaggcgt atgcggcata 1449901 tcaaaccaat attgaggtgc aaaagcttga ggagcaaatt tcatccgaaa ataagcaaat 1449961 tggtgacctc gaaaaaagcg ttgctgattt aagcaaaccg cagcgcatta tggacattgc 1450021 gaaaaagaac ggcttgaatt taaaagataa aaaagtgaaa aacatacagg aatgattcaa 1450081 atgccaaaaa agaataaatt tatgaataga ggagcagcga ttctaagtat ttgtttcgct 1450141 ctctttttct ttgtcatcct ggggagaatg gcatatattc aaataaccgg aaaagcgaac 1450201 ggcgaagtgc ttgcgacaaa agcgacagag cagcatgaaa agaaacggac catcgaagcg 1450261 agccgcggct cgattttaga ccgaaaagga aaagtcattg cagaggacac agcgacgtat 1450321 aaactgattg cgattctcga taaaaaaatg accactgatg tcaagcatcc tcagcatgtt 1450381 gtaaacaaag aaaaaacggc ggaagcattg tctaaagtga taaacttgga caaggccgac 1450441 atccttgata tcttaaataa agatgcaaaa caagtcgagt ttggctcagc tggccgggat 1450501 attacgtatt cacaaaagca aaaaatcgaa aaaatgaaac tcccgggcat ttcattttta 1450561 cgggatacaa aacgctacta tccaaacgga gtatttgcat ctaatctaat cggctatgcc 1450621 gaggttgatg aagaaacaaa tgaaatttcc ggcgcgatgg gattagaaaa agtgctggat 1450681 aagtatttga aggagcggga cggatatgtg acatatgaaa gcgacaaatc cggctgggag 1450741 ctcccgaaca gcaaaaataa aattacagcg ccaaaaaatg gtgacaatgt atatttaacc 1450801 attgaccaga aaattcaaac ctttttggaa gacagcatga caaaagtggc gcaaaagtat 1450861 aatccgaaaa aaatcatggc cgcagtcgtt gatccgaaaa cgggcaaagt ccttgccatg 1450921 ggacagcgcc caagctttga tccgaacaag cgcgatgtga caaactacta taatgatttg 1450981 atttcatatg cgtatgaacc cgggtccacg atgaagatct ttacactcgc tgctgcgatg 1451041 caggaaaacg tgtttaatgc gaacgaaaaa tataaatcag ggacatttga agttggcgga 1451101 gcacctgtta aggatcacaa taacggtgta ggctggggtc cgacaacata tcatgacggc 1451161 gtcctaaggt cgtcgaatgt cgcttttgcg aaactggcga aagaaaagct gggatatgac 1451221 cgcctcaatc aatatttgca caaattcaat ttttaccaga aaacaggtat tgatttgcca 1451281 ggagaagtct ccagcaaaat caactttaaa tatgaatttg ataaggcgtc aactgcatat 1451341 ggccaagcgt ctgcggtcac accaattcag cagattcagg ccgcaacggc aattgcaaat 1451401 gacggtaaaa tgatgaaacc ttatgtcatt gaccatatcg ttgaccctga taaagataaa 1451461 actatttatc aaaataagcc ggaatcagcc ggaactccaa tttctgcaag tactgcgaaa 1451521 aaggtgcggg atatattagg agaagtcgtt acatcgaaga tcggaacagg gcaagcttat 1451581 aaaatcgaag gttttgatgt tgccgggaaa acaggtactg cgcaaatagc cggtaaaggc 1451641 ggatatttag acggcacaga taactatatc ttttcgttta tgggtatggc gccaaaagat 1451701 gatcctgagc ttttaattta tgttgctgta cagcagccgc aactaaaagc aggacaaagc 1451761 agttcagatc cagtatcaga aatcttcaat ccaacaatga aaaatagcct gcactaccta 1451821 aacatcgaac caactgaaaa atctgactca gataaggaag aaacaaaagc gcagacaatg 1451881 cctgatttaa cagatcaaac ggtagctgct gctcaaaaga aagcaaaaga ggagaatctc 1451941 acaccaattg tcatcggcag tgatgtcgct gtaaaagaac agtatccgaa agcggatgag 1452001 gaagttctca ccaatcaaaa ggtcttcctg aaaacgggcg gcaaaatcaa aatgcctgat 1452061 atgacaggct ggtcgagaag agaggttctg cagtacggcg agctcgcggg aattcatatt 1452121 gaagtaagcg gacaaggcta cgctgtcagc caaagtgtta agaaagacaa agaaatcaaa 1452181 gacaaaaccg taatcaaggt taagtttaaa aatcctgatt aaaaagaaag ccgtcgttat 1452241 gcaggctttc tttttttatg ccttcagagg agcatcgttc tacctgtcca aattcaggca 1452301 taaaatgaaa caagcctaaa taaggagtga acggtctctt gcgcgtctcg aatgtaacgg 1452361 ttagaaaacg tttattattt gttttgcttt ttggcgtgat cgtgtttctg atcattgata 1452421 caaggctggg gtatgttcag tttgtgatgg gcgaaaaact gacttcgcta gcgaaagatt 1452481 cctggagccg gaacttgccg tttgagccgg agagaggcga gattctggat cggaatggtg 1452541 tgaagctcgc aacaaataaa agtgcgccga ccgtattcgt cgtgccgcgc caagttcaga 1452601 atccgatgaa aacgagcaag cagcttgcgg cggtgctcaa tatgtcagaa gaaaaagtat 1452661 ataaacatgt gacaaaaaaa gcgtcaatcg aaaagatcac tcctgaaggg agaaaaattt 1452721 caaatgagaa ggcgaaagaa atcaaagcgc ttgatttaaa aggtgtgtat gttgcggagg 1452781 acagtatccg tcattacccg ttcggcagct ttttatctca tgtgcttgga tttgcaggaa 1452841 ttgacaacca agggctcctt ggacttgaag cctattacga cgatgattta aaaggggaaa 1452901 aaggttctgt taagttttat acagatgcca aggggaagaa gatgcctgat gaagcggatg 1452961 actatacgcc gcctaaggat gggcttgata tgaagctgac agttgattca aaggttcaga 1453021 cgataatgga aagagagctt gataacgctg aggccaaata tcatccggac ggcatgattg 1453081 ccgtagccat gaatccgaaa aacggagaaa ttttggggat gtctagcagg cctgacttcg 1453141 accctgctga ttaccaatct gttgatccgt ccgtctacaa tcgaaatctg ccagtatgga 1453201 gcacgtatga accgggatct acctttaaaa ttattacact tgcagcagcc cttgaagagc 1453261 aaaaagtaaa tttgaaacgg gatcaatttt atgataaagg gcatgctgaa gtggacggag 1453321 cgagactgcg gtgctggaaa agaggcgggc acgggctgca gacgtatctg gaagttgtgc 1453381 agaactcctg caacccgggg tttgttgaat taggcgagcg cttaggaaag gaaaagcttt 1453441 tcaaatatat caaagacttt ggttttggac aaaaaacggg gattgatctc caaggcgagg 1453501 gaacaggcat cttattcccg cttgagagag tgggcccggt ggagcaagca actacggctt 1453561 tcggacaggg agtatccgtc acgccgattc agcaggttgc agcagtatcc gccgctgtaa 1453621 acggaggaac gctctataca ccttatattg caaaggaatg gatcgatcct gttacgaaga 1453681 aaacggtcaa aaaacaatca ccaatcgcaa agaaacaagt catttctgag gaaacatcca 1453741 aacaaatccg ctatgctcta gaaagcgtcg tcgcagaagg aaccggccgc aatgcatttg 1453801 tagaaggata tcgtgtcgga ggaaaaacgg gaactgcaca aaaggttaaa gatggaaaat 1453861 atcttgaaaa caaccatatt gtatcattta tcggtttcgc gccagcagat gatccgagtc 1453921 tagtcgtcta cgttgcggtg gataacccga aaggcacgat tcagtttggc ggaacggtgg 1453981 cagcgcctat tgtcggaaat attatgagag acagtctgcc ggaacttggt gtgaagcccc 1454041 ggaaaaatca aatcgagaaa aaataccaat ggaacgacac aaaaacaata gaagttccga 1454101 atgttgtagg gatgtctgtc tcagatcttg agtcactatt ggtgaatctc aatgtggatg 1454161 cttccgggaa agggagcaaa atcgttaaac aatcgccagc tgccggaacg aaagtaaaag 1454221 aaggctcaaa gatacgcgtg tatttgactg aagaagatga aaaggaggca gccgattgat 1454281 tcgggctgcc tattctttta ttgcagaaaa aatgctgata tctttcaaga ttagctggat 1454341 gtatcctttt atttacgcta aaatatgaac tgtatgctta aaatcattac cacatcattt 1454401 gatgtgactt caatgataaa aagaacgaat tagaatgttg agaggtttga tacgatgaaa 1454461 cttacaaagc tgcttacata cttaacaacc gaaccttctg taaacgactc acaagaccct 1454521 gaaataactt caattgagat ggactccagg gaagtaaaga aagggagtct ttttgtatgt 1454581 gtaaaagggt atacggtgga tggccacgat tttgcgcaaa aagcagtaga aaacggtgca 1454641 gcggctattg tggcagaaag agaggtcgat gtgaatgttc ctgttattat tgtccggcag 1454701 tcacttcgcg cgctcagcgt tttgtctgat gcgttttacg gacagccgac gaagaagctt 1454761 cagctgattg ggataacagg gacaaacggc aaaacatcaa cgacccacat ggtcgatgag 1454821 attctgaaaa aagcgggaaa acgcacaggc ttgatcggta caatgtacat gaaaatcgga 1454881 gacgaaacac ttcctgttaa aaacacgact ccggaaagcg tcacgctgca gaaaacgttt 1454941 aagaaaatga atgacaagca cgttgacact gcaatcatgg aggtttcttc ccacgctttg 1455001 tctttaggac gcgtccatgg ctgtgattat gatattgccg tgtttacgaa tttaacacag 1455061 gaccatctgg actatcataa aacgatggat gagtaccggc atgcaaaaag cttgctcttt 1455121 tcccaacttg gcggggcttt caaccatgaa catccaaagc gtgccgtcct gaatgctgac 1455181 gatgaggcga gcgcttattt tgaaaaggta acagctgcgc atatctctac atacggaatt 1455241 aaaaacgatg ctgatgtgat ggcgaagaac atcagtatca ctgcacaggg cacaagcttt 1455301 gatctcgtga caaacaaagg cacgaagcac atcacgatgt ctctcgtcgg acaatttaat 1455361 gtgtataacg tgctggccgc tgttgcgaca tgtattgcag caggcatacc gtttgaaatc 1455421 atcactgagg ctgttgaaga attgcatggt gtaagaggcc gttttgaatt ggtcaatcag 1455481 cagcaggagt ttcctgtcat tgtagactac gcgcacacac cggacagcct tgaaaatgtg 1455541 ctggagacat gcagagacat gacggaagga aagctatttg tcgttgtcgg ctgcggagga 1455601 gacagagata agacgaagcg cccgaaaatg gctaaaattg ctgtggagct ggctgacgag 1455661 ccgattttca cgtcagataa cccgagaagc gaagatcctc gcgcgatttt aagagatatg 1455721 gaagccggag tagagaacgc atactatcac agtattgcaa accgcgagca ggcgatcttt 1455781 ttcgcaattg ccaatgccaa aaaaggcgac gttgtcctca ttgccggaaa aggacatgaa 1455841 acctatcagc agatcggaaa tgaaactttc gattttgatg atgctgaagt agcggcgaga 1455901 gccattgttg aactcaataa gaataagacg aattcatagg aaagagatgt tactgaataa 1455961 tggagcttga aaagattttt catatggaaa aaaatcatga atatgataac tacgtatgtc 1456021 gtttgaaaga aacaggagga gaaaaggaca atgcttgagc aagtcattct gtttacaatt 1456081 ttaatggggt ttttaattag tgttctgctc tctccgattc ttattccgtt tttaagaaga 1456141 ttaaaattcg gccagagtat tagagaagaa ggaccgaaat cacatcagaa aaaatcaggg 1456201 acaccgacaa tgggcggggt catgatcata ctttctatca tagtgacaac aattgttatg 1456261 acacagaagt tttcagaaat aagccccgaa atggtgctgc ttctgtttgt tacgctaggc 1456321 tacggtttgc ttggcttttt agatgattac atcaaggttg tcatgaagcg caatcttgga 1456381 ttgacatcaa agcaaaagct gatcggacaa attattattg cggttgtatt ttacgccgtg 1456441 tatcattact acaattttgc gacggatatt cgcattcctg gaactgactt atcatttgat 1456501 cttggctggg cttactttat ccttgtgctc tttatgctag tcggcggatc aaacgcagtt 1456561 aacctgactg acggccttga cgggttatta tccggtactg cggcgattgc ctttggcgcc 1456621 tttgccattc tggcatggaa tcagtctcaa tatgacgtag cgattttctc agttgccgtt 1456681 gtcggtgcag ttctgggctt ccttgtattt aatgctcatc cggccaaagt ttttatggga 1456741 gatacgggat cgcttgcatt gggaggagcc atcgttacca ttgccatttt aacgaaatta 1456801 gagatcctgc tggttatcat cggcggtgta ttcgttatcg agacattatc cgttattttg 1456861 caggtcatca gctttaaaac gacaggtaaa cgaatcttta aaatgagtcc gcttcatcac 1456921 cattatgagc ttgtcggctg gtctgaatgg agagtagtcg tgacgttttg ggctgcggga 1456981 cttttgcttg ccgttttagg aatttacatc gaggtgtggt tataagtgga aaatgatcaa 1457041 tttttacaga aacagcattt tttaatcctt gggcttgcga aaagcggata tgcggcggcc 1457101 tccattcttc atgaaaaagg catttatgtt gcagtcaatg atcaaaagcc ttttgaagaa 1457161 aatgaaccgg cacaaaagct ttctgaaaaa ggaatcgaag ttgtttgcgg agagcatcca 1457221 gtttctctgt tcgatcagca tcaaatcacg attctgatca aaaacccggg aattccttat 1457281 gaaaatatca tggttcagga agcagagaaa cgaggtattc cggtttggac ggaaattgag 1457341 ctcgcttact acctgaccag cgccaagttt atcgggatta ccggatcgaa cggtaaaacg 1457401 accacgacaa cgctaattta cgaaatgctc aaggctgact cgcaaaaagc actgattgcc 1457461 ggaaacatcg gcacagtcgc aagtgaggtt gcctatcatg ctgatggaga tgaatggatc 1457521 gttaccgaac tgtcttcgtt tcagctgatg ggaacacacg ctttcagacc ggaaatcagc 1457581 ctgattttaa atgtatttga cgcccatctg gattatcacc atacgcgcga aaactatgaa 1457641 aaagcgaaac agaaagtgta ccttcatcag actgcttcag ataaagctat tgtcaaccag 1457701 gatgatgaaa ccgtcgtgcg tcttgctgaa gccggaaaag ccgaaatcgt cccattttca 1457761 gtcagcaaaa cgcttgaaca gggcgcatat gtaaaagaca gtatgattat gtttaacggc 1457821 gaagccattc ttcctctgga agaggttgta ctgcccggtg ctcataacct ggagaacatt 1457881 ttagcagcta ttgcagttgt gaaaacggca ggagcatcca atgaggcggt taaaaaggtg 1457941 ctgacaagct ttactggtgt gaagcaccgc ctccaatatg tcacaactgt gaatggccgc 1458001 aaattttata acgacagtaa agcaacaaac attctggcga caagcaaggc gctttcagct 1458061 tttgataagc cggtcattct gcttgcgggc ggactggatc gcggaaatgg ttttgatgac 1458121 ttgaaacctt atatgaagca tgtcaaagca gtgcttacat ttggccagac ggcgccaaaa 1458181 ctcgagaaac tcggcaatga actgggaata caacatgtca aacgtgtcga taatgttgaa 1458241 caagcagtat ctgcggcgtt tgcgctctca aatgaaggag atgtcatcct gctgtcaccc 1458301 gcgtgtgcga gctgggatca attcaaaaca tttgaagaac gcggtgacat gtttatagat 1458361 gccgtgcata tgcttaagta agggcttgtc ttgaagtaaa tcggcagccc taatgacttt 1458421 aagcttgggg tgtcgattgc tttgactact aaaaaaacat cgcctgattt gttattggtc 1458481 atcattacgt tattattatt aacaatcgga ttaattatgg tgtacagtgc gagtgcggta 1458541 tgggcggatt ataaatttga cgactcattc tttttcgcga aacggcagct tttgtttgcg 1458601 ggaatcggcg tcattgctat gttttttatc atgaatgttg attattggac ttggaggaca 1458661 tggtccaaat tgctgatggt tatctgcttt ttccttctgg tgcttgtttt gataccgggc 1458721 gtcggaatgg tgcggaacgg ttcaagaagc tggatcggag tcggagcatt cagcatacag 1458781 ccttcagagt ttatgaagct tgcgatgatt gcattccttg ctaaatttct ctctgaaaaa 1458841 caaaaaaaca tcacatcgtt cagacggggg ttcgtccctg cacttggcat cgtgttttca 1458901 gcatttttga ttatcatgtg ccagcctgac ctcggaacgg ggacagttat ggtcggaact 1458961 tgtattgtca tgatttttgt agccggcgca cggatcgccc atttcgtctt tctcgggctg 1459021 atcggcctca gcggatttgt cgggctcgta ctatcggctc catatcggat aaagcggatt 1459081 acctcatact taaatccatg ggaagacccg ctcggaagcg gatttcagat cattcaatcg 1459141 ctttatgcag tggggcccgg cgggttgttc ggaatggggc tcggacaaag cagacagaag 1459201 ttcttttatc tgcctgagcc gcaaacagac tttattttcg ccatcttgtc agaggagctg 1459261 ggctttatcg ggggaacact tattttgctc ctcttcagcg tcctgctgtg gagaggaatc 1459321 agaattgcgc ttggtgcgcc tgatctgtac ggaagctttg tcgcagtcgg cattatttca 1459381 atgattgcca ttcaagtcat gataaatatc ggcgtagtca cgggcctgat tcctgtaaca 1459441 ggcatcacgc tcccgtttct gagctacgga ggctcttcat tgactctaat gctgatggca 1459501 gttggtgtgc tgctgaatgt aagccgctac tcgaggtatt aacgaatgta tttccaagcc 1459561 tcctgtctaa catgaagctt ggaaacaatt gatgcgataa ccctgtccaa caaaacaggg 1459621 ttatcgttat gttatagaga aacttagact gggggaaaaa agaaatgcga attgcaataa 1459681 gcggaggcgg tacaggggga catatttatc ctgctcttgc ttttattaaa gaagtgcaaa 1459741 gacgtcatcc taatgtggaa tttttatata tcggaacaga aaacgggctg gagaaaaaaa 1459801 ttgttgagcg ggagaatata ccgtttcgtt caattgaaat tacaggattt aaaagaaaat 1459861 tgtcatttga aaatgtcaag actgtgatgc gttttctgaa gggcgtcaaa aagagtaaat 1459921 cgtatttagc ggaatttaag cccgatgccg taattggaac gggcggttat gtatgtgggc 1459981 cggttgtcta tgccgctgcg aaaatgggaa ttccgactat tgtccacgaa caaaacagcc 1460041 tgccgggcat cacgaataag tttctttcaa aatatgttaa taaagtagcg atttgttttg 1460101 aagaagcgaa atcacatttt cctagcgaga aagttgtatt tacgggaaac ccgagagcct 1460161 ctgaagtcgt ctcaataaag acgggacgat cattggctga atttgggctt tctgaagaca 1460221 aaaaaacggt cttaattttc ggcggaagcc gaggcgctgc accgattaac cgcgctgtca 1460281 ttgacatgca ggatgtgctg aaaacaagag actatcaagt gctgtatatc accggtgaag 1460341 ttcactatga aaaagtaatg aatgagctga aaagcaaggg tgccgctgat aatatggtca 1460401 caaagccgtt tcttcatcaa atgcctgagt atttaaaggc cattgatgtc attgtggcca 1460461 gagccggtgc gacaacgatt gccgaaatta ctgctctcgg aatcccaagt gttctgatcc 1460521 caagtccata tgtgacagcg aatcaccagg aggtcaatgc gaggtctctt ggccagcatg 1460581 atgcggcgat tgtactgaaa gaaacagagc tcagcgggga gaagctgatt gaagcgctag 1460641 accggattgt actgaatgag caaacgttaa aggaaatgag cgaacgaaca aagtcactcg 1460701 gtgttcctga cgcggctgcc cgtttataca gcgtactcga ggaattaaaa aaatagtaga 1460761 aaagcaaatg gaatgcggag gtttacgatg gagaaagtga tacaggaatt aaaagaacga 1460821 gaagtcggca aggttcttgc aaatgaaccg ctcgcgaatc atacaacgat gaaaatcggc 1460881 ggacctgcgg atgtattggt cattccaagc agtgtggatg ctgttaaaga catcatggac 1460941 gtgattaaaa aatatgatgt gaagtggaca gtcatcggcc gcggatcaaa tcttcttgtt 1461001 ttagatgaag gaattagagg cgtagtgatc aagctggggg cgggtcttga ccatttggag 1461061 cttgaagggg aacaagtaac agtcggaggc ggttattcgg tggtccgcct tgctacatca 1461121 ttgagcaaaa aaggcctgtc cggtttggaa tttgctgccg gcattccagg atcagtcggc 1461181 ggagcggttt atatgaatgc cggcgctcac ggttctgata tgagcgagat cctcgtcaaa 1461241 gcgcatattt tatttgaaga cggaacgatt gagtggctga caaatgagca gatggatttc 1461301 agctacagga catctgtact gcaaaagaaa cgcccgggcg tttgccttga agctgttttg 1461361 cagcttgagc agaaggataa ggaatcaatc gttcagcaaa tgcaaagcaa taaagactat 1461421 agaaaaaata cacagccgta ttcaagccct tgtgcgggaa gcatattcag aaatccgctt 1461481 ccgaatcatg ccgggaacct tgtagaaaaa gcaggcttga aaggatatca aatcggcggt 1461541 gcaaagatat cggagatgca cggaaacttc atcgtcaatg cggggggagc atcagcaaaa 1461601 gatgtgcttg atctcattga ccatgtgaaa aagacaatcc gtgaaaaata cgagattgat 1461661 atgcacacag aggttgaaat catcggcgga aatcgctgat tcaagttctg actgaagctg 1461721 ttcatatgat atactgtaag caaacgacaa acggcatcat agtatgccgt ttgttttgga 1461781 atagacagac ttttaacagc tgtttcattt gaatgaggtg aacaggcaat gaacccgggt 1461841 caagaccgag aaaaaatcgt taacattgaa gagcggatcc ctaaaattaa agagcagagg 1461901 aaacaaaagg caaaccgccg tctcatttca tttattatgc tcttttttat tatggtgctg 1461961 atcattgtgt acctgcaaac accaatcagt aaagtatcaa caatctctgt tacagggaat 1462021 gaaaatgtat caaaaaagga aattatcgac ctttccgata ttaacagcgg agatactgag 1462081 ttttggagtt tggacaagca aaaaacagaa aagaagattc agcaaaataa attagtgaaa 1462141 aaagcggaga tcagcaaatc gcttcctaat aaaatcaaca ttgcaatcga agaatataaa 1462201 gcgattgctt atttagaaaa agacgatgtg tactatgaag tgcttgaaaa cggctcagtt 1462261 ctgccaaacg aagtaacgcc ggatgatgcc ggaccgattt tagtgaattg gacaaacgcg 1462321 aagaagcggt ctcaaatggc caagcagctc gatgcgttgt caaattcgtt aaaacagtcg 1462381 atttcagaaa tttattatac gcctgtaaaa atggatgaaa accgtattaa gttgtacatg 1462441 aacgacggtt atgttgttac ggcatctatt aaaacgtttg cagaccgaat gaagacgtat 1462501 ccttctatca tctcacagct aagcagcaat aaaaaaggaa tcattcattt agaagttgcc 1462561 acctattttg aagagtttgg gaaaaacgat aaagctgcta aaaaggaaga tgaaaattga 1462621 ggggcaaatc agcagtcctt ctttccttga ttatgcttat cgcaggtttt ttgatttcat 1462681 tttcttttca aatgacaaaa gaaaacaaca aaagcgcggc tgagacggaa gagtggaaaa 1462741 aagaatatgc gctgagagat gaactgctga aacaagagaa agaaaataag aagtttgaaa 1462801 aagaattata tcaaaagcaa aacaaagtcc gccaggcgga aaataagctg aagaaagaga 1462861 agtcggaata ctataatgtc ctcgaagata cagaaaaata caggatgtat attggggaag 1462921 tcggtgtgca gggagaaggc gttgaggtga cattggaaga tgcgtcatac ataccggaag 1462981 gggagaatgt gaatagttac atcgttcacg aaagccatat cttccaagta gtaaacgaac 1463041 tgtatatctc aggagcggca gctgtcgccg ttaatggaca gcgtttgacg catgattcgt 1463101 atatcaaatg caatggtcct gtggtaacgg tagacggggt gcagcatccc gctccgttta 1463161 cggtatccgc tattggagat ccagatgtcc tgctgccctc gttaaatatc gctggaggcc 1463221 taattgatca gctgtcaatg gatcatattt ctgtgtcggc agaaaaagag aaaaacgtac 1463281 aaatgaaacc gattctgaaa acgaaggaat gactgaaaaa gcgggtgaaa tagattgaaa 1463341 ataaagcgtt ccttcataag catcagtgtt cttatggtca tcttcggcct gatgatatct 1463401 gttcagttta attcgttaaa gcaccccaaa gtccgggata caagagatat gtgggatatt 1463461 agggaagagc tgacatcaga gcagaagaag caggaaaagc tgctggctga aataaacaaa 1463521 tatgacaaat tgctgaatag ctattcgcaa acgaaagaaa tgacaaaaga aaccgcgcta 1463581 aataatacct tgcaatcctt aaaaaaaaca gccggcatga ccgatataac aggtagcgga 1463641 attgtcatta cgatttcccc gcttttttct gaaagcttaa caggagagcc gatcgaaaat 1463701 ccgcctccgg atttgctgaa aaagctgata aatgaactca actcctacgg tgcagagcat 1463761 atctcgatta atgagcgaag agttgtgaat catacagtca tcagagatat aaacggcact 1463821 acaaaaatag acggatacgc ccttgacgat tatcctttaa cagtaaaagt gcttgccaaa 1463881 gatccggaca tgttacacag cagagtgaag gggtcaggcc ttgaggatct ttttgcatct 1463941 gaaaatttag cattaaaagc cggtaaatct gaaagcaaac taacattaaa agcatatgac 1464001 agaccactgg acgtacaaca gctgaaactg cttaaagact gaaaaggagg agaattgtca 1464061 tgtggctgcc cgtgttggga ctggtgctcg gaatagcgat tggactaatg acaaacttaa 1464121 cgataccgag tgaatactca aactatttat cgcttgcggt gcttgccgca cttgatacat 1464181 taatcggcgg aatcagggcg catttacaag gtacatatga tgaaatggta tttgtttccg 1464241 gtttcttttt taatattata ttggcaataa gtttagcttt tctgggagtc catcttggtg 1464301 tagacttgta tttagcaggt atattcgcat ttggagtcag attatttcag aatatagccg 1464361 ttatcagaag aaatctacta acaaagtgga ctctttctaa aaaaaataaa aaaaatgtga 1464421 tataaaagag gatatacata ggatataacg aatattttca ataaacataa aatgtgaaaa 1464481 gcacataaaa atattctgtt gttatttttt gttacacact tgtaaagcca cattcattgt 1464541 attgttgttc cgcaaataat agaatagaaa tgatcgaaat gtgaggaggt gccatagaat 1464601 gaacaacaat gaactttacg tcagtcttga catcggtacg tccaatacaa aagtgatcgt 1464661 cggagaaatg acagatgatt cccttaatat tatcggtgtg ggaaatgtac cgtctgaagg 1464721 gttgaaaaaa ggctcaatcg ttgatataga tgagaccgtt cattctataa gaaaagcgtt 1464781 tgaccaagct gaaagaatgg taggttttcc gcttagaaaa gctattgtcg gcgttaatgg 1464841 aaattatatc aatattcaag atacaaacgg tgttgtagca gtttccagtg aaaataaaga 1464901 aattcaggtt gaagatgtac gccgtgtcat ggaggcggca caggttgttt ccgtaccgca 1464961 tgaacagctg attgttgacg tcattcctaa acagtttatc gtagatggaa gagatgaaat 1465021 caccgacccg aaaaaaatgc tgggtgtgcg tttagaagta gagggcacct tgatcaccgg 1465081 ttcaaaaaca atcttacata acttactccg ctgcgttgaa agagctggta ttgaaataac 1465141 tgatatttgc cttcagccgc tggcagccgg ttctgctgca ttatcaaagg acgagaaaaa 1465201 ccttggtgtg gctctcattg atataggggg agggtcaaca accattgccg tattccagaa 1465261 cggacatctc acttctaccc gtgtcattcc tctcggaggc gaaaatatca ccaaagatat 1465321 ctccatcgga ttgagaacgt caacagaaga agcagaacgc gtgaaaaagc aacttggaca 1465381 tgcctactat gacgaagcct cggaagatga aatatttgag gtaaccgtta taggcaccaa 1465441 tcaaaaacaa acatttacac agcaagaagc agcgaatatc attgaagcga gagtagagga 1465501 aattcttgaa attgtttcag aagagcttcg cagtatggga attaccgatc tgccgggagg 1465561 cttcgtgctg acaggaggac aagcagctat gccgggtgtc atgtctttgg cacaggatgt 1465621 gctgcaaaac aatgtcagag tggcaagccc gaattatatc ggtgtaagag atcctcaata 1465681 tatgacggga gtgggcctga tccaattcgc ctgccggaat gcaagaatcc aaggcagaaa 1465741 aataggcttt aagatgcctg aagaagcgat acaggaaatc gcagtctcat catctgagga 1465801 acaagagcag catcatcacc aaaatgaggt gcagcagcgg ccaaaaggaa aacaaaaaac 1465861 acaagccgaa cataataaac agagcaaaat gaaaaaacta ttaagcatgt tttgggaata 1465921 gatagatagt cattcggcag attaggagga tttagcatgt tggagttcga aacaaacata 1465981 gacggcttag catcaattaa agtaatcgga gtaggaggcg gcggtaacaa cgccgttaac 1466041 cgaatgattg aaaatgaagt gcaaggagta gagtatatcg cggtaaacac ggacgctcaa 1466101 gctcttaacc tgtcaaaagc agaagtgaaa atgcaaatcg gcgcaaagct gactagagga 1466161 ttgggagcag gtgcgaatcc ggaagtcggg aaaaaagccg ctgaagaaag caaagagcag 1466221 attgaagaag cacttaaagg tgctgacatg gtattcgtga cagctggtat gggcggcgga 1466281 acaggaacag gtgccgcacc ggttatcgca caaatcgcga aagacttagg cgcattaaca 1466341 gtcggcgttg tgacaagacc gtttaccttc gaaggacgca aaagacagct tcaggctgca 1466401 ggcggaatct cggcaatgaa agaagcggtg gatacactga tcgtgatccc gaacgaccgt 1466461 atccttgaaa ttgttgataa aaacacaccg atgcttgaag cattccgcga agcggataac 1466521 gtacttcgcc aaggggttca aggtatttct gacttgattg ctacacctgg tcttatcaac 1466581 cttgactttg ctgatgtgaa aacaatcatg tcaaacaaag gatctgcttt gatgggtatc 1466641 ggtattgcta ctggggaaaa tcgcgcggca gaggcagcaa aaaaagcaat ttccagcccg 1466701 cttcttgaag cggccattga cggtgcgcaa ggcgtcctca tgaacatcac tggaggaaca 1466761 aacctcagcc tatatgaggt tcaggaagca gcagacattg tcgcttcggc gtctgatcaa 1466821 gacgtaaaca tgattttcgg ttctgttatt aatgaaaatc taaaagatga gattgtggtg 1466881 acagtgattg caaccggctt tatcgaacaa gagaaggacg tgacgaagcc tcagcgtcca 1466941 agcttaaatc aaagcatcaa aacacacaat caaagtgttc cgaagcgtga gccaaaacgt 1467001 gaggaacctc agcagcagaa cacagtaagc cgtcatactt cacagccggc tgatgatacg 1467061 cttgacatcc cgacattctt aagaaaccgt aataaacgcg gctaatgtaa aggacaaaat 1467121 cgttttcgat tttgtccttt tttgtttttc tcttcacact ttccttctta taaagtcttt 1467181 ttccctattg cttccttcgc gagctcgatt atggatggtt tacgttttgg aaaaagtaag 1467241 gtatcctagt tcgtacaaag ttttatgaaa attaaaacaa ttataaaagg caataaagag 1467301 gaggaccacg atgattttgc agcttgacaa tgtctcacta aaacggaatg ggaaatggat 1467361 actgaaagat attcattgga aggtggaaga aaaggaaaat tgggtgcttt acggcctaaa 1467421 tggcgccggg aagacagcgc tgttaaatat gctttgctca tattattttc caacatcagg 1467481 cgagatgcag gtgctcggcc atgaatttgg caaaacagag cttggggaaa agctcagacg 1467541 taaaattggc ctcgtctcag cagctcttca gcaaaaattg tatccggcag attcagcttt 1467601 tgaaattgct ttgagcggag cttacgcttc gattgggtta tatgaaacgc caagtaagga 1467661 aaccagggaa aaagcgatag gtttgttaga ggacttggga gcaattgaat atgccgatcg 1467721 ccgctatgaa accctttctc aaggggaaaa acaaagagca ttgattgcta gagcactaat 1467781 ggccgatccg gagctgctga tactggatga accagtcaca ggactggatt ttattgcccg 1467841 ggaaaagctg ttagatacga ttacatacat tgcaaacaaa gaaaatgcac catctatcct 1467901 ttatgtgact catcatgctg aagaaatttt gcctgtcttt gataaagccc ttttattaaa 1467961 acagggagag gtttttggat ccggagaaat aaaggaaatg cttactgatc aaatactttc 1468021 cgcttttttt gatacgccaa tccatgtatt atggaatcag gatcggccgt ttttaacaag 1468081 agctgagccg ataacgaatg cctgacaaat atatatagat tcatcctagg ggtgctttgc 1468141 gaagctgaga gagactttgt ctcaaccctt ttgacctgat ctggatcatg ccagcggagg 1468201 gaagcggtga aaagcggagt acatcggact ccgtttgttt ttattaagcc gtttcatcac 1468261 atttgaaacg gcttttttga ttttaaagaa taggagcgga tttacattgg atcaacaaat 1468321 atactctttg caaaaaaaag tggaagaaca taaggaggag cttattcagc ttgcgaaaac 1468381 gctgatttct tatcaaacac ctgctccgcc tgcaagaaat acagagggca ttcagtcttg 1468441 gattgcggga tatttaaatg aattgggatt ctcgatcgac aaatgggatg tgtaccctgg 1468501 agatcccaat gttgtaggga agctaaaagg aacagattca gcagattatt atagcctgat 1468561 tatcaatggc catgtagatg tggcagaggt aaaagaggat gaagaatgga agcacgatcc 1468621 gtttcatccc attgaaaaaa acggtctctt aatcgggcga ggcgcttccg atatgaaggg 1468681 cggaatggct tgtgtgctgt ttgctgtcaa attaattcgt gaagcaagca ttgaacttcc 1468741 aggtgatctg attctgcaat cggttattgg ggaggaagtt ggagaggccg gcacacttga 1468801 atgctgcaag aggggctacc acgctgattt tgcaattgtc gcggatacga gcgatatgca 1468861 tattcaaggc caaggcggtg tcattacagg ctggatcgaa atcaaaagca gtcaaacatt 1468921 tcatgatgga acgagacgga atatgattca tgcaggcgga ggaacattcg gagcaagcgc 1468981 aattgaaaaa atggcaaaaa tcattgcggg gctcggtgaa cttgagcgcc actggtctat 1469041 tatgaaaagt tatcccggtt ttaaaccagg cacaaatacg attaacccgg cagttataga 1469101 aggcggcaga catgcggctt ttatagcgga cgaatgccgg ctgtggatca cagtccattt 1469161 ttatccgaat gaaacccatg accaagtggc agcggaaata gaagattacg tcaatcggct 1469221 gagtgacagt gatatttggc ttagggaaaa ccgccctgta ttcaagtggg gaggctcatc 1469281 tatgatagaa gacaggggag aaatttttcc ggcattggaa gttgaccctg gccacccagg 1469341 cgtcttagcg ctaactgcct ctcatcagaa agtgaaacgg gagtgtccaa ttattgacgt 1469401 ttctcaatca gttacagatg gcggatggct gtatgatgcc ggtattccat gcgtaatata 1469461 cggtcctgga gatctgcaca atgcacactc tgtgaacgag aaggtatcga ttgagcagct 1469521 agtagagtat acaaaaatta tactcgattt tatcatcagc tggtgcagcc ggaaaaaaga 1469581 acaatgacat gaaaatttct tcttgctgac aaggttcagc ctgcccgttc atatacttga 1469641 acaaaaggac ggaaaaagga cgtgatggaa tgatcagcat ttcagaattt caggtaaagg 1469701 atgtcgtcaa tgtctcaaac ggaaaaaagc tggggagtat tggtgatatt gatatcaatg 1469761 tgaccactgg aaaaattcag gcgatcatac tcggaggaaa tgggaaagtt ctcggatttt 1469821 ttggaaaaga agaggaattg gtcattccat ggcgaaatat agtaaaaatc ggggaagatg 1469881 taatcttagt ccgattaagt gaaccacatg cataaacctg cttgtctgcc gcagattggc 1469941 aaatgccgga agtctcgatt cttccggcac atttcattta gaaatatgca aatcggcgct 1470001 caacgaatgc agtaagatgt ggtaaaataa gtgggaaatt ccgctttttt aaatgtttgt 1470061 cgaaaggttg gatcatcatg aatacatatc acccattcag tcttaccaca ccctcgacac 1470121 tcatgataca agactgggct caaacgaatc aaaacaacaa agaggtcatt gccggattta 1470181 cgacaaaaaa cggcggtgtc agccaaaagc cttttgaatc gttaaataca ggattgcacg 1470241 ttcatgacaa agatgcagat gtagttaaaa atcgtgaata tattgccgat atgtttaata 1470301 ctgatttgca gtcttgggta ttcgctgatc agacacatga taatcgcgtt cagaaagtga 1470361 cgcagaggga taggggaaaa ggcgcccgtg agtatcacac ggctctaaaa gcaacggacg 1470421 ggatctatac aaatgaaaaa aatgtatttt tagcattatg ctttgctgat tgtgtgcctc 1470481 ttttctttta tgatccggtt aagtcgcttg tcggagtcgc ccatgccggg tggaaaggca 1470541 ccgtcaaaca gattggcaga gaaatggtga agcaatggac tgagaaggaa ggttcaaatc 1470601 cctcagatat ttacgctgtt attggcccgt ctatcagcgg agcatgctat acggtagacg 1470661 accgcgtcat ggatgctgtc cgcgcattgc cggtttcagc agaccttgcc gccaatcaga 1470721 cggcaaaggc acaatatcag cttgatctga aagagctgaa ccgtcttata ctgatggaca 1470781 gcggtttggc aagtgaacaa atttctgtca gcggtttatg cacggaaagc gagccgtctc 1470841 ttttctattc tcatcgccgc gatcagggga aaactggacg gatgatgtcc tttatcggaa 1470901 tgaaggaggc ataaaagatc ttgcgtgttg ttgataattt acgacatata aacgaacgaa 1470961 taaacgaagc atgtaacaga tcgggccgca gctccgatga agttacggtt attgcagtca 1471021 caaaatatgt atcacctgaa agagcacagg aggcagtaga tgctggcatc acctgcctcg 1471081 gagagaatcg ggatgcggaa ctgctccgca aacaggaatt gatgaaaggg aatccggaat 1471141 ggcattttat cggcagtctg caatcaagaa aagcaaaatc tgtcgtcaat tcggtttcct 1471201 atatccattc cctagaccgg ctctcattag cgaaagaaat tgaaaaacgg gctgaaggta 1471261 ctgtacgatg ctttgtgcag gtcaatacct ctcttgagcc ttctaaacat ggcatgaaaa 1471321 aagaagaagt cattccattc atacaggagc tttccggttt cgaacatatc cttgttgccg 1471381 ggctgatgac aatggctccg ctgactgatg atcaagatca gatcagaagc tgtttcaggt 1471441 cgctgagaga actccgtgac caggttcaga agctgaacca gccgaacgct ccgtgtactg 1471501 aactgtcgat gggcatgtca aatgattttg aaattgcaat tgaagaagga gctacttata 1471561 ttagaatcgg ctcatcgtta gtcggaaatg aaacaggggg tgtacagcaa tgagtatgaa 1471621 aaataaactg aaaaactttt tctcaatgga agatgaagaa tacgaatatg aatatattga 1471681 gacagagcgg gaatctcatg aggagcatga gcaaaaagaa aagccggctt acaacgggaa 1471741 taaacctgcg ggcaaacaga atgtagtgag cttgcaaagt gttcagaaat cctctaaagt 1471801 ggtgttgagt gagccgcgcg tttatgcgga ggcgcaggaa atagccgacc atttgaagaa 1471861 ccggcgggca gttgtcgtca atcttcagcg gatacagcat gaccaggcga agcggattgt 1471921 tgacttttta agcggaaccg tttatgccat tggcggcgat attcaaagaa tcggctcaga 1471981 tattttcctc tgcacgcctg acaacgtaga tgtatcaggc acaatttctg agctcatatc 1472041 tgaagacgaa catcagaggt ggtaaagcga gatgatcctt tatcaagttt tttcggtttt 1472101 aagcttatta atcacaatat actcatttgc cctgatcata tatattttta tgtcatgggt 1472161 gccgagtacg agggaaacag cagtcgggcg ttttttggct tcgatttgtg aaccatatct 1472221 cgaaccattc agaaaaatca tccctccgat tgcaatgctg gatatttcac caatcgtagc 1472281 aatacttgtg cttcggtttg cgacaaccgg cttgtgggga ctttatcgca tgattgcgtt 1472341 ttaatgtgac agtttgatag gggcttggca gcagccaagc ctctttacat agaagggaaa 1472401 gacgatgagc gatatatatc agcacttcag aaaagacgag cgggccttta ttgatcaagc 1472461 gctcgaatgg aaaagaattg tccaggagca gtaccggatg aagctgaccg actttttaga 1472521 tccccgagag caggtcatcc tctctgctgt tacgggacag gcagatgtcg ggcttgcctt 1472581 ttccggcggc tatgacagag cggagcggaa acgggcgatt ctgtttccag agtacattac 1472641 tccggaagaa tcagattttg aactgcaggc gtttaacgtc cgttatgctg acaagtttgt 1472701 ctcagtagat catcgttctc tgcttggtgc attaatgggc ataggattaa agcggcaaaa 1472761 attcggtgac atcgtgtttt ctgagacagc agtgcaattg attgtctcag ccgataccgc 1472821 tgattttgtg gctgcacagc tgacccaagc aggcaaagcg gcggtcagcc tagagaaaat 1472881 cgacttgtca gaccttaaca ttccagcagt tgatgtcgaa ataagagatg acacggtttc 1472941 ttctttaagg cttgacgccg tctgcgcctc tatgagcagg caatcccgcc agaaatcaca 1473001 gacgcttgtg aaaaacggcc ttgtgaaagt gaactggaag gtggttgaag atccttcata 1473061 catagtcgcg gaaggggaca tgctgtctat cagaggtttt ggccggtgca gcttaacaaa 1473121 aatcgaagga aaaaccaaaa aagacaaatg gagagttacg tttgaacgac aaaaatagtc 1473181 ggtttttcag tttttttctc catctgtgcg aaatttgttt tataatgtga actagataac 1473241 cgtactgaaa tgtaaaaatg gaggtggcat catgccatta acgccaaatg atattcacaa 1473301 caagacgttt acaaaaagtt ttcgcggata tgatgaagat gaagtaaatg aattcctagc 1473361 ccaagtcaga aaagattacg aaattgttct ccgcaagaaa actgagcttg aagcgaaagt 1473421 caatgagctt gatgaaagaa tcggacactt tgccaatatt gaggagacat tgaataaatc 1473481 aattttagtt gctcaagaag cggctgaaga cgtaaaacgc aattctcaaa aagaagcaaa 1473541 gctgatcgtt cgggaagcgg agaaaaacgc tgatcgcatt atcaacgaat cgttatcaaa 1473601 atcaagaaaa attgcaatgg aaattgaaga gctgaaaaaa cagtctaaag tgttcagaac 1473661 acgtttccaa atgctgattg aagctcagct tgatcttctg aaaaatgacg attgggatca 1473721 tctccttgag tatgaagtcg acgctgtatt tgaggaaaag gaataaattc tctgattatc 1473781 ttgacatttt cttagcttgt cgaatataat acgttcataa attcagatga aaaaacggtt 1473841 gaaagggaca gtcatgtttc cttcaggcct tcatagcgac ccggagatgg tgagagtccg 1473901 ggatggccgg aatcatgtag atcagccctt tagtttcctt gctgaactca cagtaggtta 1473961 ggacgttcat cacgttacga tgctcaagag gaaaaagtgt atgcttgctt tttctaaaag 1474021 ggtggtaccg cgagataagc tttctcgtcc cttatgggat gagagggctt tttttatttt 1474081 ctgaaaaaat gcagtggagg aatgaaaatg gattttaaag acacgctctt aatgccgaaa 1474141 acagatttcc cgatgcgtgg aaatttgcca aaccgtgagc ctgacattca aaaaaaatgg 1474201 gaggaagaag atatctaccg tcttgttcag gaacggacga aagaccgccc gaaatttgtt 1474261 ttacatgacg gacctccgta tgcaaacggc gacatccata tgggccatgc acttaacaag 1474321 attttgaaag acttcattgt ccgctataaa tcaatgagcg gctacaacgc accgtatgtg 1474381 ccgggctggg atacacacgg attgccaatt gaaacagctc tgacaaaaaa caaaaaggtc 1474441 aaccgcaaag aaatgtcagt agcggaattc cgcaaactat gcgaagagta cgcttggaag 1474501 caaatcgagg gacagcgtga gcaattcaaa cgtcttggtg tccgcggtga ctgggaaaac 1474561 ccatatgtga cattaaaacc ggaatacgaa gcgcagcaaa tccgcgtatt tggtgaaatg 1474621 gcaaaacgag gctacattta caaaggcctt aaaccggtta actggtcacc ttcaagtgag 1474681 tctgctctgg ctgaagccga gatcgaatat caagataaac gttcagcatc tatttacgtc 1474741 gcttttggtg taaaagacgg aaaaggcgtt cttgaaaacg gcgagcgcat catcatttgg 1474801 acaacaacgc cgtggacaat tccggcgaac ctcggaatct cagtgcaccc tgatcttgag 1474861 tacagcgtga ttgcagtagg tgaagaccgc tttgttgtag caagtgcctt agtcgaaaat 1474921 gttgcatcgg catgcggatt tgatcagtat gaagtgacaa gaacggtcaa agggaaagac 1474981 cttgagaaca ttatcgctga acacccgcta tatggcagag actctctcgt tatgcttggt 1475041 gaacacgtaa caactgatgc cggaacaggc tgtgttcata cagcgcctgg acatggggaa 1475101 gatgacttta tcatcggcca aaaatacggt ttagatgtgc tttgcccggt cgatgaaaaa 1475161 ggtgtaatga caagcgaagc tcctggcttt gaaggcatgt tctatgatga tgcaaacaaa 1475221 gcgatcacac agcagcttga tgaaaaaggc gcacttgtga agcttgaatt cattactcat 1475281 tcttatccgc atgattggag aacaaaaaaa ccaaccattt tcagagcaac agcgcaatgg 1475341 tttgcgtcta ttaaagattt cagatcagac ctgctggatg ccattaaaga aaccaaatgg 1475401 gttcctgaat ggggcgagca gcgtttgcac aacatggttc gggaccgcgg agactggtgt 1475461 atttccagac agcgtgcgtg gggtgtgccg attccggtat tttacgctga aaacggagaa 1475521 ccggttatta cagatgaaac cattgaacat gtttctgaat tgttcagaca gcatggatca 1475581 aacatttggt ttgaaaaaga agcaaaggat cttcttccgg aaggctttac gcatcctggc 1475641 agcccgaacg gcacatttac aaaagaacag gatatcatgg atgtttggtt tgattcaggc 1475701 tcttcacatc aagcagtgct tgaagaacgt gatgacctcg ttcgcccggc tgatctatac 1475761 ctagagggat ctgaccaata tcgcggctgg tttaactctt ctctttctac agcagtagcc 1475821 gtaacaggga aagcgccgta taaaggtgtg ctcagccatg ggttcgcact ggatggagaa 1475881 ggacgtaaga tgagtaaatc aatcggtaac gttgttgttc cggctaaagt catgaaacag 1475941 cttggtgccg acatcttaag attatgggta tcttcagtgg attatcaggc ggacgttcgc 1476001 gtgtctgacg ccattctgaa gcaggttgcg gaagtatatc gtaaaatccg caacacgttc 1476061 cgtttccttc acggcaacct tttcgatttt gatccaaaaa caaatgcggt ggctgtcgaa 1476121 gatcttcgcg aagtggatca gtatatgctg attaagctga acaagctgat tgataaagtg 1476181 aaaaaagcgt atgatgagta cgaatttgcg gttgtgtatc acagcattca taatttctgc 1476241 acaatcgaat tgagctcatt ctaccttgat tttgcaaaag atattgtcta catcgagcat 1476301 gcggatcatc cggatagacg cagcatgcag acagtattct acgaaacgct tcttgcatta 1476361 gtgaagcttt cagcgcctat ccttccacat acggcagacg aattgtggtc tcatttaaca 1476421 tttgttgaag agcagagcgt tcagttgacc gatatgccgg aaacaatcac ggttccaaac 1476481 agtgaagcga ctgaagaaaa atttgaccgc tttatggctc ttcgtgatga cgtgttaaaa 1476541 gcattagaaa ctgcgcgaaa tgaaaaaatt atcggtaaat ctttggaagc aaacctgaaa 1476601 ttgtatccaa acaaagaaaa caaggagctc ttggcttcca taaaagaaaa cctttctcag 1476661 ctgtttattg tgtctgaact gacaatcagc gaagaaaatg aagcgccgaa cgatgcgcaa 1476721 agctttgcga cgggtaaaat cgctgtcgag aaagcggaag gcgaaatgtg tgagagatct 1476781 cgtgtgattt caaaagatgt aggggcaaat ccgaaatatc ctacactttc attacgcaac 1476841 gctgaaatcg ttgaaaaata ctatcaaaaa taatgcaaaa gagcccggcg taaaagccgg 1476901 gctttttttg tgccaagagt gacatccttt agaacgaaag gaaaaatctt atgggcttta 1476961 gatcatcatt cacaggcaac aataaagata ctacgttaag agcaggagtt gtgaagaatg 1477021 aatgatcaac tgaccgcaat ttatacggaa cttcttctga tgaaagaaga attacagtcg 1477081 agattatttg agtattcttg ctttcaggtt tctacaagcc cgcaagcagc aatcaatcaa 1477141 aaacaaaaag caactctgat ctatcatatt aaagaagaac ttcaagacgt tctccttgca 1477201 ttgtccaaaa tcgaaaacgg cacattcgga tactgtgaag aaactggggc ccccattcct 1477261 cttgcaaagc tggcagtgct gccgacggcc cgaacagcaa acgattttct ttattctgtc 1477321 caatttgaga aaaaaacgct tccgatatgg aaatcaacgg atatcgaata tggtcaggca 1477381 ctgtatgaat aacagtgtct gtccggttaa tatgcctgat atttctttac tccagtgctt 1477441 tttattgata aaatgcataa tggattaaag taaccgtaaa ctggaggaac gtttgtgctg 1477501 tattatatga ttgcactact tattattgca gccgatcaat tgacaaaatg gctagttgtt 1477561 aagaacatgg aacttggcca aagcattccg atcattgatc aggtattcta tatcacctcc 1477621 catcgcaata cgggtgctgc atgggggata ttagcgggtc aaatgtggtt tttctacctc 1477681 ataacaaccg ctgttattat tggtattgtt tattacatac agcgttatac aaagggacaa 1477741 aggcttcttg gcgttgccct cggacttatg cttggcggtg ccatcggcaa ctttatcgat 1477801 cgggctgtca gacaggaagt tgtggatttt atccatgtta ttattgtcaa ttacaattac 1477861 ccgatattta acatcgcgga ctcttcacta tgtgtcggcg taatgctttt atttatacaa 1477921 atgctgttgg acagcgggaa aaagaaaaag gagcaatagc atgaatcaaa ttgatataac 1477981 cgcttcagaa gaacaaaaaa gtgagcggat tgataaattt ttggcatcga ctgagaatga 1478041 ttggtcaaga acccaggttc agcaatgggt aaaagacgga caggttgtcg tgaacggaag 1478101 cgcggtgaaa gcgaattata aaattcagcc gggtgatcag gtgaccgtca ctgtacctga 1478161 accggaagcg ctcgacgtcc tggcagagcc tatggatctg gatatttatt atgaggacca 1478221 ggatgtgctg gtcgtcaaca aacctcgcgg aatggttgtt cacccagcac ccgggcatct 1478281 tacgggcaca cttgtaaacg gtcttatggc tcattgcaca gacctttccg gaataaatgg 1478341 tgtgatgcgc ccgggtattg ttcacagaat cgataaggac acgtccggtt tattaatggt 1478401 ggcgaaaaat gatatggcgc acgagtcact cgtaaaccaa ttggtcaaca aaacggtcac 1478461 gcggaaatat acggcggttg tccacgggct tatttctcat gatgacggca caattgacgc 1478521 gccgatcgga cgggataaaa aagaccgtca aagcatgact gtgacacgtg atggcaaaaa 1478581 cgctgtcact cattttcatg tgcttgagcg ttttcaggat tttacgttag tggagtgcca 1478641 gcttgaaaca gggagaaccc atcaaattcg tgttcatatg aaatatatcg gattcccatt 1478701 agcaggcgat ccgaaatacg gcccaagaaa aacaatcgac tttaatggcc aagcgcttca 1478761 cgcgggagtt ttaggttttg accatccacg aacaggagaa tatgtcgaat ttgaagcgcc 1478821 gcttcccgag gatatggcag aattaatcga aaacctcaga aaaaacggtt gacagagggt 1478881 ttcttttctg aaataataaa cgaagctgaa tagattcttt aaaacagtcc agagaggctg 1478941 agaaggataa cggatagacg ggatgcgtgt ataggcgcgc accttgtcct aaaacccctc 1479001 tatgctctgg caggaggggt tttttcttct atatgaactg tgaggtgtca cacattgaat 1479061 caaaaagctg tcattctcga cgaacaggca attagacggg cgctgaccag gattgctcac 1479121 gaaatgatcg aacgcaataa aggaatgaat aactgcattc ttgtcggcat taagacaaga 1479181 gggatttacc tggcaaaacg ccttgcggaa cgcattgaac agattgaggg aaatcctgtt 1479241 acagtcggtg aaattgatat tactctttac agagatgatc tttctaaaaa aacaagcaac 1479301 gatgaaccgc ttgtaaaagg tgcagatatt ccggtagata ttacagatca aaaagtcatt 1479361 ctcgttgatg atgttctgta taccggaaga acagtcagag caggaatgga tgcgcttgtt 1479421 gatgtaggca gaccttcctc cattcagctt gcagtgcttg tggacagagg acaccgggag 1479481 ctgccgatcc gagcggatta tatcgggaaa aacatcccga catcaaagtc tgaaaaggtt 1479541 atggtacagc ttgatgaggt agaccaaaac gatctcgtcg ccatttatga aaacgaataa 1479601 tagatcacct ttttaagggc aatccagaga ggttgcaaag aggtgcacaa caaaggccca 1479661 aaaagtattc ggcaggtctt tgtatgcctc tttgcgtaaa aaagcaaaga ggttttttta 1479721 tacagtcatt gagtcatcct aaaatgaaag tcaacaatca gggggaaatc atcatgagta 1479781 agaaaaaagt aaatttaggg gtcagggatg tcccgacacc tttctcttgg gtttcattca 1479841 gccttcagca tttgtttgcc atgtttggct caaccatttt ggttccgaag ctcgtcggaa 1479901 tgagtcctgc tgtggcgttg gtgacaagcg gcatcggaac actggcgtac cttcttatta 1479961 ccaaaggaca aattccggcg tatctcggtt catccttcgc ctttatttct ccgatcattc 1480021 tggtaaaagc gaccggcggg ccgggagcgg caatggttgg agcgtttctt gcagggctgg 1480081 tgtacgggct gattgcctta ttgattaggc agcttggaac aggatggctg atgaagattc 1480141 tcccgcctgt agtcgtaggg cctgttatta tcgtcatcgg gctgggactg gcaagcactg 1480201 cagtaaacat ggcgatgtat gctgatccga acgcgagtga gttggtctac agcttaaagc 1480261 actttagtgt cgcaggagtt acgctggcaa ttacgattat ttgtgcgatt ttcttacgag 1480321 ggtttttaag cctgattccg gttctgatcg gaatcatcgg cggatacctg tttgccctta 1480381 ctcaagggat tgtcaacttc cagccggtgc ttgacgcgaa atggtttgca gtgcctgaat 1480441 ttatcattcc gttcaaagat tattcaccgt cagttacgct cggcatcgca gccgcaatgg 1480501 ttcctgtcgc atttgtcaca atgtcagagc atatcggcca ccaaatggtg ctgagcaagg 1480561 ttgtcggaca agacttcatt aaaaagccag gtcttcatcg ctctattatg ggtgacagtg 1480621 tggcgacaat cctcgcttcc ctgatcggcg gccctccgac aacgacttac ggagaaaaca 1480681 ttggcgtgct ggccatcaca agagtattca gcgtctttgt catcgggggc gcggcagtga 1480741 ttgccctttg cttcggcttt atcggcaaaa tttcagcgct gatcagttca gtgccgtcag 1480801 cggtcatggg aggcgtctcc ttcctgctgt tcggaatcat tgcttcaagc ggcctgagaa 1480861 tgctgattga caacaaaatt gattatgaaa acaacagaaa cctcattatt acatcagtta 1480921 tccttgtcat cggtgtagga ggcgctttta tccaagtgtc tcagggcgga ttccaagtgt 1480981 caggaatggc gcttgccgca attgtcggtg tcatcttaaa cctgattctt ccgcaggcga 1481041 aggaagagca ggcagacaca tctgaacaac atcatattta aaacctttta atgaaagtcc 1481101 agagaggctt ggaagggtta tgaagagaag gaagcttcaa tgctgccctc tatttaacca 1481161 taccccgagt ctatcttaga ccggggtttt ttttcagcct taagttgaaa agagagggga 1481221 aagaacatga agcatttaac gacgatgagt gaacttagca ctgaggaaat caaagatttg 1481281 cttcaaacag cacaagagct caaaagcgga aaaacagaca atcagcttac aggaaagttt 1481341 gcagcaaacc tgtttttcga accgagcacg agaacgcggt tcagctttga ggtcgcagaa 1481401 aaaaagctgg gcatgaatgt gcttaacctt gatggaacaa gcacaagcgt gcaaaaaggc 1481461 gaaaccttat atgacacgat ccggacgctt gaatcaatcg gtgtggacgt ctgcgtcatc 1481521 aggcacagtg aggatgagta ttatgaagag cttgtcagcc aggtgaacat tccgattctg 1481581 aatgcgggag acgggtgcgg ccagcatcca acacaatcac tgcttgattt aatgacgatt 1481641 tatgaagagt tcaatacgtt taaagggctt accgtctcca ttcacggcga catcaagcat 1481701 agcagagtgg caaggtcaaa tgcggaagtg ttgacaagat tgggtgcccg ggtcctattt 1481761 tccggccctt cggaatggca ggatgaagaa aatacattcg gcacgtatgt ctcaatggat 1481821 gaagcagttg agtcttccga tgttgtcatg ctgctgcgca ttcaaaatga acgacatcag 1481881 tccgctgtca gtcaggaagg ctatttaaac aaatacggct tgaccgtaga acgggctgag 1481941 cgtatgaagc ggcatgcgat catcatgcat cctgctccgg taaacagagg agtggagatt 1482001 gatgacagct tagtagaaag cgaaaaatca agaatcttca agcaaatgaa aaatggcgta 1482061 tttatcagaa tggcagtgat acagcgtgcc ttacaaacca atgtgaaaag aggagaagca 1482121 gcgtatgtca tatctcatta aaaacggctg gatactaaac gaaaatggtg aaaaaacaca 1482181 agcggatatc cgagtgactg gagaaaccat caccgcaatc ggcaagcttg atgcaacgga 1482241 taatgaaacg gtaattgatg caaaaggttt gctcgtttca cctgggtttg ttgatctcca 1482301 cgtgcatttc agagagccgg gcggagagaa aaaagaaact attgaaaccg gggcaaaagc 1482361 agcggcgcgc ggcggctata ctacagtagc agcaatgccg aatacgcggc cggttcctga 1482421 tacaaaggag cagatggaat gggtgcaaaa cagaattaaa gaaacatcat gcgtaagagt 1482481 tcttccatat gcatccatta cgatcagaca aatcggcgat gaaatgacaa actttgaagc 1482541 gttaaaagaa gccggggcat ttgcttttac agatgacggc gttggtatac agacagcagg 1482601 aatgatgtat gaagcgatga aacgggcagc cgcaattgac aaagcgattg ttgcacattg 1482661 cgaggacaac tccttaattt acggagggag cgtacatgag gggacattct ccaaagcgaa 1482721 cgggctaaac ggcattcctt ctgtgtgtga atcggttcat attgctcgcg atgtgctgct 1482781 ggctgaggcg gcaaactgcc attatcatgt atgccatatc agcacaaaag aatctgtcag 1482841 agttgtacgc gatgcgaaaa aagcgggaat cagagtgaca gcagaagtat cgccgcatca 1482901 tttgctgctt tgtgatgagg acatcccggg gctggacaca aactataaaa tgaatcctcc 1482961 gctccgcagc ccagaagaca gagctgcttt aattgaaggt cttttagacg gaacaattga 1483021 ttttatcgca acagaccatg caccgcatac ggaagaagag aagaacacag aaatgaagct 1483081 ggcgccattc ggaattgtcg gcttagaaac agcattcccg cttctttaca cacactttgt 1483141 caaaaatggc agctggtcac tgaagcagct gattgactac atgacaatca agccatgcga 1483201 agcgttcggt ctcccatatg gaacattaca aacggggcaa gctgcggaca ttacgttaat 1483261 cgatttagaa aaagaagcag ttatagacaa agagacattt ttatcaaaag gaaaaaatac 1483321 accattcaac ggcatcagtt gcaccggctg gccggtcgct acaattgcgg cagggaagct 1483381 tgcttatgaa gaggggagac ttgtcaaatg aagagacgat tagtactgga aaacggagcg 1483441 gtattcgagg gagaagcttt cggaagctta gaacacaaca tgggagaagt cgtttttaat 1483501 actgggatga caggctatca ggaaatttta tctgatcctt cttactgcgg acagatcgta 1483561 acattaacat acccgcttat cggaaattac ggcattaacc gtgatgattt tgaatccatt 1483621 accccttttg tcaaagggct gatcatcaaa gaattatgtg agctgccttc caactggcgt 1483681 tcagcataca ccttagacga gtatttaaaa atgaaaaaca ttcccggact ccagggaatt 1483741 gatacaagga agctgacaag aatgatccgc acggcaggcg cgctaaaagg aacattcgct 1483801 tcatctgatg aagatatcga agcagtgctg aaaagactga acgaaacgga attgccaaga 1483861 aatcaagtat cccaagtatc agcaaaaaca gcatatccga gcccgggaag aggcaaacgc 1483921 attgtcttgg ttgacttcgg catgaaacac gggattctaa gagagctgaa caaacggaaa 1483981 tgtgacgtca tcgttgtgcc ttacaacatt acagcggaag aggtgcttca gctgaaaccg 1484041 gacggtatca tgctttctaa cggacctgga gacccgaagg atgtgcctga agcgattgaa 1484101 atgattaaag gtgttcttgg aaaagtgcca ttattcggaa tatgtctcgg ccaccaatta 1484161 ttcgcgctgg cgtgcggggc gaatactgaa aaaatgaaat tcggccacag gggctcaaac 1484221 cacccggtaa aagagctggc tacaggaaaa gttgccttaa catctcaaaa ccatggatat 1484281 acagtttcgt ctatcagtaa aacagaactg gaagtgacgc atatcgcaat taacgacgat 1484341 acgattgaag ggctgaagca taaaacattg ccggcattta cggttcaata tcatcccgaa 1484401 gcctcacctg gtcctgagga tgccaaccat ctatttgaca gattcatcga aatgatcgaa 1484461 acaacagaga aagaagggga agcggtatgc caaaacgcgt agacattaac aaaattttag 1484521 taatcggatc tggaccgatc atcatcggcc aagcagcaga atttgactat gcgggaacac 1484581 aagcctgtct tgctttgaaa gaagaaggct atgaagtcat ccttgtcaac tcaaaccctg 1484641 caacgatcat gacagataca gaaatggctg accgggttta catcgaaccg ctcacacctg 1484701 aattcctgac acgaatcatc agaaaagagc gcccggatgc cattcttcct acactcggag 1484761 gccaaaccgg tttgaatctt gcggttgagc tttctgaaag aggcgttttg gcagaatgcg 1484821 gcgtcgaagt gcttggcacg aaactgtctg cgattcagca agctgaagac cgtgacttgt 1484881 tcagaacatt aatgaatgaa ctgaatgaac cggtgcctga aagtgagatt atccactccc 1484941 ttgaagaagc agaaaaattc gtcagtcaaa ttggattccc tgtcattgtc cgcccggcat 1485001 atacattagg cggaacaggc ggaggcatct gctcgaatga aacagagcta aaagaaatcg 1485061 ttgagaacgg cttgaaatta agcccggtac accaatgtct gcttgaaaaa agcatcgccg 1485121 gctataaaga aatcgagtat gaagtcatga gagacagcca ggatcacgcc attgtcgttt 1485181 gtaacatgga aaacattgat ccagttggaa tccatactgg agacagtatt gttgtcgcgc 1485241 cgagccaaac gctcagcgat cgcgaatatc agctcttgcg gaatgtatcg ttaaaactga 1485301 ttcgcgcgct tgggatcgaa ggcggatgta atgtccagct cgccttagat ccagacagct 1485361 tccaatatta cattattgaa gtaaatccgc gtgtcagccg ttcatctgcc cttgcatcaa 1485421 aagcaacggg gtacccgatt gcaaagctcg ctgctaaaat tgcagtcgga ctttcattag 1485481 atgaaatgat gaacccggtg acaggaaaaa catatgcagc atttgaacct gctcttgact 1485541 atgtcgtatc caaaattccg cgctggccgt ttgataagtt tgaatcagca aacagaaagc 1485601 ttggcacgca aatgaaagcg acaggtgagg tcatggcaat cggccgcacg cttgaagagt 1485661 cattgctgaa ggcagtgcga tcactggaag cggatgtgta tcatcttgaa ttgaaggacg 1485721 ccgctgacat ttcagatgag cttcttgaaa agcgaattaa aaaggccggt gatgaacgct 1485781 tattctactt agctgaagcg tacagaagag gctacacggt agaagacctc catgaatttt 1485841 ccgctatcga tgtcttcttc ttgcataagc tgttcggaat cgtacagttt gaaaaagaat 1485901 tgaaggccaa tgcgggcgat acagatgtgc tgagacgggc aaaagaactc ggcttctctg 1485961 atcagtacat cagccgtgaa tggaaaatga aagaatctga gctttacagc ttgagaaaac 1486021 aagcggggat tgcgccggta ttcaaaatgg tagatacatg cgcggcggaa tttgagtcag 1486081 aaacgccata cttctatagc acatatgaag aagaaaatga atctgtcgtt acagataaga 1486141 aaagtgtgat ggtgcttggt tcgggtccga ttcgaatcgg tcagggtgtc gagttcgact 1486201 atgcgacggt tcactctgta tgggcaatta aacaagcagg ctatgaagcc attattgtca 1486261 acaacaaccc ggaaaccgtt tcaacagact tcagcatctc agacaagctg tattttgaac 1486321 cgcttacgat tgaagatgtc atgcacatca ttgacctcga acagccaatg ggcgttgtcg 1486381 tacaatttgg cggacaaact gcgattaacc ttgctgacga gctttctgca cgcggagtga 1486441 aaatccttgg aacttcatta gaagatttag accgtgccga agaccgggat aaatttgaac 1486501 aagcgcttgg agaacttggt gttcctcagc cgcttggcaa aacagcgaca tcagttaatc 1486561 aggcggtaag catcgcaagt gatatcggtt atccggtact ggtacgccct tcctatgtac 1486621 ttggcggccg ggcgatggag attgtttacc atgaagagga actgcttcat tacatgaaaa 1486681 atgcagtcaa aatcaatcca cagcaccctg tattaattga tagatacttg accggaaaag 1486741 aaattgaagt cgatgcagta tccgacggtg aaacagtcgt cattccggga attatggagc 1486801 acattgaacg tgcgggcgtt cactccggag actcaatcgc tgtttatccg cctcagtctc 1486861 tcacagagga cattaagaaa aaaattgaac aatacacgat cgcattggct aaagggctga 1486921 atattgtcgg tttgctcaat attcaattcg tcttgtcgca aggcgaggtg tacgtgctag 1486981 aagtgaatcc gagatcaagc agaaccgtac cgtttttaag caaaattacg ggtatcccaa 1487041 tggcgaatct cgcaacaaaa atcattcttg gtcaaaagct ggctgcgttt ggctatacag 1487101 agggccttca gcctgaacag caaggtgtat ttgtaaaagc gccggtcttc tcctttgcca 1487161 agctgagaag agtggatatt acgttagggc ctgaaatgaa atcaacaggt gaagtcatgg 1487221 ggaaagattc gacacttgaa aaggcgctct acaaagcctt gatcgcttca ggtattcaaa 1487281 tcccgaacta cggttccgtg cttttaacag tagctgataa ggacaaagaa gaagggcttg 1487341 ccattgctaa gcggttccac gcgatcggct acaacatttt agcgacggaa ggaacggcag 1487401 gctacctgaa agaagcttcc attccagcga aggtcgtcgg aaaaatcggt caggatggcc 1487461 cgaacttgct tgatgtcatc agaaacggag aagcgcagtt tgtcatcaat acgctgacaa 1487521 aaggaaagca gccggcaaga gacggtttta gaatcagacg tgaatcagta gaaaatggtg 1487581 ttgcctgcct aacatcttta gatacggcag aggcgatatt gcgagtgctg gaaagcatga 1487641 cattccgtgc tgatcaaatg ccggcagtca acacaaatca ggaggcggca gtcactatat 1487701 gaaaaaagcg tatttgacag tatgttctaa ccagcaaatt gcagaccggg tgtttcaaat 1487761 ggttctgaaa ggggagcttg tccaagggtt tacaacccct ggacagttcc ttcatcttaa 1487821 agtgagcgaa gcggttacgc ctcttttgag aaggccgatc agcatcgcag acgtcaactt 1487881 tgaaaaaaat gaagtcacca tcatttatcg ggtagatggg gaagggacaa gactcttgtc 1487941 actgaagcag cagggagaac ttgtggatgt cctcgggcct ttgggaaatg gctttcctgt 1488001 taatgaagtt caacccggaa agacggcttt gctggtagga ggcggagtag gtgtgccgcc 1488061 tctccaagag ctgtcgaaac gcttgattga aaaaggggta aatgtcatcc acgttttagg 1488121 attccaatcg gcaaaggatg ttttttacga ggaagaatgc cggcagtacg gagacacgta 1488181 tgtggcaaca gctgacggaa gctacgggga aaccggattt gtcacagatg tgattaaacg 1488241 gaaaaagcta gagtttgata tcctcctcag ctgcgggccg acaccgatgc tcaaggcgtt 1488301 aaaacaggaa tatgcccata aagaagtata tctgtccatg gaggaacgaa tgggctgcgg 1488361 aatcggcgca tgcttcgcgt gtgtgtgcca tacaaacgaa agtgagacat cctatgtaaa 1488421 agtatgtctc gacgggcctg tatttaaagc tcaggaggtg gcgctgtaat gctagaggtg 1488481 aaattgccgg gacttgattt gaaaaaccca atcattcctg catcaggctg cttcggtttt 1488541 ggaaaagaat tttcacgttt ttatgatttg tcttgtcttg gagctatcat gattaaggct 1488601 acgacaaagg agccgcgctt tgggaatccg acgccgcggg tagctgagac tggtgctgga 1488661 atgctcaatg cgatcggtct ccaaaatccg gggctggata gtgtgttgca tcatgagctg 1488721 ccgtggcttg agcagtttga tacaccgatc attgccaatg tcgcaggttc tcaagtcgat 1488781 gattatgttg aagtcgcaga acatatcagc aaagcgccta atgttcatgc tcttgaattg 1488841 aatatttcct gcccgaatgt gaaaacaggc ggaatcgctt ttggcacgaa tcctgaaatg 1488901 gctgccgatt tgacaaaagc ggtgaaagag gtttcggatg tacccgttta tgtgaagcta 1488961 tccccgaacg tggctaatat cacagaaatt gcattagcga tcgaggaagc gggagcggac 1489021 ggtcttacga tgatcaacac actaatcggc atgagactcg atttaaaaac cggcaaaccg 1489081 atattagcga ataaaacagg gggactttcg ggccctgctg tgaagccggt tgccattcgc 1489141 atggtgtatg aagtcagcca gatggtcaac atcccgatta tcggaatggg aggcgtgcaa 1489201 acggctgaag atgccctgga atttcttctc gcgggagcaa gcgcagtcgc tgtcggaaca 1489261 gcaaactttg tgaatccttt tgcatgtcca gagattattg aacagctccc atctgttttg 1489321 ctccaatacg gctatcaatc aattgaagaa tgcatcggaa ggagctggaa tcatgaaaaa 1489381 caacctgccc atcatcgcgc ttgattttgc gtcagctgaa gaaacacttg cgttcttagc 1489441 gccttttcag caagaaccgt tatttgtaaa ggttgggatg gagctttttt atcaagaagg 1489501 gccatctatc gtgaaacaac taaaagaaag aaactgcgag ctatttttag atctaaagct 1489561 tcatgacatc ccgactactg taaacaaagc gatgaagcgc cttgccagtc ttggagtaga 1489621 cctcgtcaat gttcatgctg ccgggggcaa aaaaatgatg caggcagctc tcgaaggctt 1489681 agaagaaggt acgccggctg gaaaaaaacg tccgtcactt atcgcggtaa cccagctgac 1489741 aagcacatct gaacaaatca tgaaagatga actgctgatc gaaaagtctc tgattgatac 1489801 ggttgtgcac tacagcaaac aggcggaaga aagcggactg gatggagtgg tctgctctgt 1489861 tcatgaagca aaagccattt accaagcggt gtcgccttca tttctgactg tcactccggg 1489921 gatcagaatg tcagaggacg ctgcgaatga ccaagttcgc gtagcgacgc ctgccattgc 1489981 aagagagaaa ggttcatcag cgattgtagt aggacgctcg attacaaaag cggaagaccc 1490041 ggtaaaagcc tataaggctg tcagacttga atgggaggga atcaaatctt gaaacaaatc 1490101 atcgcaaaac atctattaga catccaagct gtatttttac gcccgaacga gccgttcaca 1490161 tgggcaagcg gcattttatc accgatctac tgtgacaacc gccttacgct atctttccca 1490221 gaggtcagaa acgatgttgc ttcaggtatc agcaagcttg ttaaagagca ttttcctgaa 1490281 gctgaaatga ttgcgggaac agcaactgcc ggtattcctc atgctgctct tgcggcggac 1490341 catttgaatc ttccgatgtg ttatgtgagg agcaagccga aggcgcacgg aaaaggcaat 1490401 cagattgagg gagctgtgca agaagggcaa aaaacagtcg tcattgaaga cttaatttcc 1490461 acaggaggca gcgtgcttga agcttgtgca gctttacaag cggccggctg tgaagtgctt 1490521 ggtgtcgtct caatctttac gtacggactt cctaaagcgg aggaagcctt cgcaaaggca 1490581 gaactgccat actactcatt aaccgattat gatacgctca cagaggtcgc gcttgaaaac 1490641 ggaaatattc attcagatga tctaaaaaag ctgcaaacat ggaaacgaaa tcccgagtca 1490701 aaagattggt ttaaaaaata aaaaataaat tcaaatgatg taaagaggct tcaaagcctt 1490761 gctgtacttg aaaacaggct gtgaggcctg tttttttatt aatcctataa aaaaagtcgg 1490821 gttgacttat gttagaattg tgctaaaatt tactacaaat ctaaaaactt atcaagagcg 1490881 gctgagggac tggacctatg aagcccggca acctgcatag tttgtaaggt gctacttcca 1490941 gcaaaatgaa ttccattttg aaagataagg gctgcatgct gttcctgtct ttctttccgc 1491001 cggattgaaa gttttttatt ttaagaggta aaaaggctat ctgtatatca gcagccgcga 1491061 atcacattac atgggaaaag acaaccggca gaaagctact gtttgtttgt ctccgaaagg 1491121 aggaaagaag aaatgttaac gtatgataat tgggaagaac caacgattac atttccggaa 1491181 gacgatcctt ataaaggagc gctgtcagtt ttaaaatggg catacggcca ttacggcgat 1491241 cagcttgttt atgcctgcag tttcggaatt gagggaatcg ttctgattga cttaatttat 1491301 aaagtgaaaa aagacgcaga gattgtgttt cttgatacag gacttcattt taaagaaacc 1491361 tatgaaacaa ttgaacgagt gaaagagcgt tatccgggtc ttaatatcat cctgaaaaaa 1491421 ccagatctca cccttgagga acaagccgaa gaacatggtg acaaactatg ggaaagagag 1491481 ccgaatcagt gctgctatct tagaaaggtc gttcctttaa gagaggcgct ttcaggacat 1491541 ccagcctggc tttccggcct gcgccgtgat caagggccaa gccgtgccaa tacgaatttc 1491601 ttaaacaaag atgaaaaatt caagtcagta aaagtttgcc cgcttatcca ttggacttgg 1491661 aaagacattt ggagatatac atcccggaat gaactggact acaatccgct tcatgaccaa 1491721 ggctatccaa gtattggctg tgcgccttgc acttctcccg cttttacagc agaagatttg 1491781 cgctcaggca gatggaatgg tatggcgaaa acagaatgcg gactgcatga ataaggagct 1491841 gcaaaatgga attagccgct attttattta gcttgttttt cgcgatgaat attggtgcaa 1491901 gcggcgctgc agcttcgatg ggggttgctt acggctccgg agccatcaaa aagaaaactt 1491961 acgctttgat cctatgcgca gtcggtgtct ttgccggggc ggtcattggc ggaggcgagg 1492021 ttgtaaaaac aatcagctcc ggcattattc ctgagcagac gattacactg acgattgttt 1492081 gcatcattat tggagctgct gccctgtcgc tctttactgc taatctgctc ggcattcctt 1492141 tgtcgacaag tgaagtaaca gtcggcgcgg ttgtcggcgt gggagtggct tataaagtat 1492201 tgtttgtgaa caatcttctg atcattgtgt cattttgggt ttttgtcccg ctgttcgctt 1492261 tcggcttcac ctatttcgta tctaagctgt ttcgttattt taagattgaa gtaaaatctt 1492321 ctaaaaagca aaaaatcctc ggcattgttt tgttagttgc cggatttttc gaagcattct 1492381 ctgccggcat gaataacgtg gcgaatgctg ttggcccgtt agtagctgcc ggtgtgcttg 1492441 atgtcggaaa aggaaccttg tatggaggag cttttgttgc tcttggcgca ctgttattag 1492501 gccggcgagt gctagaaaca aacgggaaga aaattacgag gttctccaaa ggggaaggca 1492561 ttctcttatc cggtacagga gcgggactgg tgatcatcag ttctgtattt gggatgccgg 1492621 tgcccttggc gcaagtcacg tcatcgtcta ttatcggaat aggcatggcg aaaaacggtc 1492681 cgaacgtgtt ccataaacaa gttgttcaaa cgatgctgaa ggtatggatc gtatcgccgt 1492741 ttttatcttt atcgatttct tatctgcttg tatccttgtt tttaaaagca gattattatt 1492801 cgatctttat catggtaagt gtgcttttag cggcgggcgg tgccatcagc ctgacaaagg 1492861 ccattcgtaa agagagacgc tcagtccacg aacaaggcgg gggaatctga tcattaatct 1492921 gagtaatttt ataagttaac taggaggaga tggatattat gagcttagca ccacacggag 1492981 gaacattagt aaacagagta gatgaatcat atgatgtgag cggcattcaa aaagaaattg 1493041 aacttgattt aatttctttc gcggatttgg aattgatcgg tatcggtgca tacagcccga 1493101 ttgaaggttt ctttaatgaa aaagattacg tatcagtggt cgaaaacatg cgtctttctt 1493161 ccggcgttgt ctggtctctt ccaatcacgc ttccggtcga tgcgcaaaaa gcagcggaac 1493221 tgtcacttgg tgaaacggta aagttaacgt atgaaggaga aacttacggc gttatccaaa 1493281 tcgaagacct gtacgtgcct gacaaacaaa aagaagctgt caatgtgtac aaaacagatg 1493341 aacaggagca tcctggtgtt aaaaagctgt tcagccgcgg caatacatat gtcggcggac 1493401 cgattacgtt gattaaaaaa gcttcaaaac agttccctga atttacattt gaaccgtcag 1493461 aaacgagacg ccagtttgcg gaaaaaggct gggaaaccat tgtcggtttc caaacaagaa 1493521 accctgttca cagagcgcat gaatacattc aaaaaacggc tcttgaaaca gtagacggct 1493581 tgttcttgaa tccgttagta ggtgaaacaa aatctgatga cattccagct gatgtacgga 1493641 tggaaagcta ccaagtgctt cttgatcatt attacccgaa agatcgtgtt ttccttggtg 1493701 tctttttagc ggcgatgcgt tatgcaggcc cgagagaagc aattttccac gcgcttgtca 1493761 gaaagaacta cggctgcaca catttcatcg tcggccgtga tcatgcaggt gtaggcgact 1493821 attacggaac atacgaagca caggaactgt ttgacacatt taaacctgaa gaactcggaa 1493881 ttacaccgct gaaatttgag cacagcttct tctgtaaaaa atgcggaaat atgggaacag 1493941 caaaaacttg ccctcatggc agagagcatc acgtcatttt atcaggcact aaggtaagag 1494001 gtatgctgag agacggtgtg ctgccgcctg ctgaattcag tcgaaaagaa gtagtagaag 1494061 tgttaatcaa agggatgaag aaaaaagaag aagtaggcgt atcttaagga ggactggcag 1494121 tgacaaatcg cgatattgta tggcatgaag cctctatcac aaaagaagag tatcagcaaa 1494181 aaaacaagca taaaagctcc attctctggc tgacagggtt aagcggctca ggcaaatcaa 1494241 ccattgccaa cgccgctgcg agagaattgt ttgagcaagg ctaccaagtc attgtgctgg 1494301 acggggataa tatccgtcac ggcctaaata gggatcttgg tttttctgat gaagaccgaa 1494361 aagaaaacat ccgccggatc ggagaggtgg cgaagctttt tgttcagcag ggaaccattg 1494421 tgattactgc ttttatctct cctttccgcg aggacagaca acaggttcgc gagcttgtgg 1494481 aagcgggcga atttaatgaa gtctacatta aatgcgacct tgatatttgt gaacaaagag 1494541 atccgaaagg gctttacaaa aaagcaagaa acggcgagat tccgttcttt acaggaattg 1494601 attctcctta tgaagaaccg gaagctccag agctcgttct tgattcagga cagcatgacc 1494661 gtgaagcgtg taaaaatcag ctgatcgagt ttgttaaaca aaaattgagc tgaatatgat 1494721 ctgctgcgtt cttctcagat gccggaatgc aagcgagaac atcatcacag cgaatcttct 1494781 ggaagaactc gaatagatcg ggggaaatac gatggggaaa gtatatattg taggagcggg 1494841 tcccggtgac cctgatctgc tgacaattaa agcgctgaaa gccattgaaa aagctgatgt 1494901 catcttatat gacagattag taaataaaga gattttacaa tatgccaaag agcaagcaga 1494961 cctgatctac tgcgggaagc ttccggattt tcatacgatg aagcaggaaa ccatcaatcg 1495021 atttcttgtg aagtatgcgc aaaaagggaa aatggttgtc agactgaaag gcggagaccc 1495081 ttttgtgttc gggagaggag gggaagaagc ggaatgcctc tctgaaaatg gaattccgtt 1495141 tgaaatcatt cccggcatta cgtctggaat cgcggcagcc gcttatgccg ggattcctgt 1495201 tacccatcgg gatgcgggct ctaacgtcgc ttttgtaacg ggtcactata aaaaagaaga 1495261 agattttgag gaaaagtgga aagcgctggc tacaggaatt gatacacttg tcatctatat 1495321 gggtatcaaa aacgtgcagc agattgaaag aaaactcctt gaaaatggcc gggacggttc 1495381 tacgccagca gcctttattc attgggggac aacggacaag caaaaatctg ttttttgtac 1495441 agttgacacc ctttcagaaa cggtgataaa agaaaacatt acaaatccga gtttaattgt 1495501 cattggaaat gttgtaaatt atcactataa gctggaatgg tttgaatctg aactaaaaaa 1495561 acaagattta agcgaggcgt tgtaaaaatg aaacaagcaa ttttatatgt cggccacggc 1495621 agccgggtca aaaaagcgca gcaagaagcc gcagcctttt tggaaggatg caaggcccac 1495681 atctctgtgc cagtacaaga aatcagcttt ttagagcttc aggagccgac aattgagaca 1495741 ggatttgaag catgtgtgaa gcaaggtgcc actcatatcg cagtggtgcc tctgcttctt 1495801 ttaacagctg cgcatgcaaa acatgatatt ccggaagaaa ttgtccgtgt tgcatctcga 1495861 tatccatcag tccgtatttc atacggaaag ccgatcggga ttgacgaaga agtagtcaag 1495921 gctgtatatc accgaatgaa agacataggt gttccgtatg aaaatgccag agtggtgctc 1495981 atcggaaggg gaagttcaga tccagacgtc aaaagagacg taaccggaat tgctaatctt 1496041 cttcaggaaa tggttccagt gaaggaagtc attccgtgct ttttgacagc atgcggccct 1496101 aattacaaag aggttttttc agaacttgaa aaagatgacg gcataacaac ctttatcgtt 1496161 ccatatttgc tttttacggg tatgctgatg aatgaaatcg aacgagaggt tcagaaatta 1496221 aaagcccata atccgaacgt ctacctctct tcctatatcg gttttcatcc tcatgtgaaa 1496281 aacgcatttt tgaaccgtgt gagagaaact gcggcaaatt ctgagggaca atttgatttt 1496341 gatggaggtt catatgcttc cgctgcacat tagcctggaa aagaagaagg ttgtgattgc 1496401 ggggggcgga agcatcgctc tcagaaggct gaaaacggtg atttctgagg gagctgatat 1496461 aacgcttgtc agtccggatg tggaaccgga aatcaagcaa atggcagaag agcggcgtat 1496521 caaatgggaa aaacggacaa ttgaaaaaga agattatctc aatgctttct tcattattgc 1496581 tgcgacggat aatgcggcag tgaacaaaga aattgcccaa tccgcttcgc cttttcagct 1496641 tgtcaattgt gtcagtgacg ctgagcttgg caatgtatat atgccgaaaa tcgtaaaaag 1496701 agggcatgtc actgtgtctg tttctacaag cggagccagt ccaaagcaca cgaaagagct 1496761 tgctgaaaac gtggataagc tgattgacgg cgattttgtt gctgaagtga acaggcttta 1496821 tcagatgaga agaaagaaat aagccagagc atacaaatgc tctggctttt ctttatgcgg 1496881 ctcagctttt tttgagcttg atgacagtat cagcatcagg cgtgacaaag acggtatgct 1496941 ggctgtcata agtgacgaaa ccgggtttcg cgccgtttgg ttttttgaca tgcctgattt 1497001 ttgtataatc tacaggcact gaacttgaat ctttagcttt tgaaaaataa gctgcaattg 1497061 tcgcggcttc catgattgtt tgctcatcag gttcgctgct tctgatcaca acgtgggagc 1497121 cgggaatgtc cttcgtgtga agccagatat cgtctctggc cgccactctt gtcgttaaat 1497181 attcattttg acgattgttc ttacccacta aaattgtcag ccctgaggtg gattcatatg 1497241 tttctaacac cggattgtgc ggtttttgct ttttctggcc tttttgctgc ttagggcgta 1497301 aatatttgcc ctcaacaagc tcttccctga tttcgctgat atcccgggga gaagcggacg 1497361 aaagctgctg aatcagctga tcaaaatatt cgatctcttc ctgtgccagc ctgatttgct 1497421 cctcgacaac tgcgaccgaa tttttcgctt tctgatactt cgtgaaatag gcctgtgcgt 1497481 tttcagaagg cgttttgttc gggtttaaag gaatcgtgat tgtcgggctt tcttcatcat 1497541 aataattgat gacctcagcc tgtttatcac cttttttcag catatataaa ttagcggtta 1497601 aaagctctcc gtaaagctga aattccttcg cgttttccga atactccagg gttttctcta 1497661 attttttgat tttgttggca ttcttcttcc gttcgttcac aacaaaacgc tcaagatcct 1497721 gagcctgttg cttaacccgg tctcgttcag cttttccgaa ataaaaacgg tcgagcagtt 1497781 cgcttaatga atcaaaacgg cgcgcttcgc cctttagatg agtcagctcc agcagataaa 1497841 aatattcctt tccgtttaca gtcgtaatgt tgggaatgaa acggtgctct ttcacttcgg 1497901 caaacagtgc cagcaacgct tttggcagtg tgactttgtt ggcaaggcct gctctgtgaa 1497961 ccgcttcttt ggcgaaaagc ggagacacgc ctgaaaagtg gtcgacaatt tgtttatcaa 1498021 gccttccttc ttgaaagctg aggtgacgca aaatatcatc ttctgacgcc tcaagaggcg 1498081 atattttgtc ctgagcaggc ggaagcttat aatcttggcc gggcagtact gtacggtagc 1498141 tgttcattga cggtgataaa tgcttaagtc cgtcgataat cacattttct gctgcgtcag 1498201 tcaaaatgat attgctgtgg cggcccataa tttctacata aagctttcgt acggtttcat 1498261 cgccaatttc gtttcggctt ttgatatgaa aaatcataat gcggtctaag cccgcttgtt 1498321 caattttctc aatgaatccg ccttcgatat gctttctcag caacatgcaa aacattggcg 1498381 gttcgcttgg attttcataa gcttgtgccg tgatatgcac ccgtgaatag ctcggatgtg 1498441 ccgataataa tagtttttgg ttttttccct tggcacggat gtggaaaatc acatcgtgct 1498501 tatatggctg atggattttt gtaattcgtc cgcccattat tttctcgtta agttcgtgtg 1498561 tcattccgta tgtaaacatg ccatcaaacg acatatgcaa tacaccctct cattcttcct 1498621 gcattcgata attatagcat gaaatgggac gagtcagaat aagcatgctt atagagtgat 1498681 atctctataa gagagcaggg gagtggacga gcggaatgaa gtttcatgaa atgggacaaa 1498741 cagatttact agaggcaacc aatacgtcca tgaaacaagg attaacagaa aaagaggtaa 1498801 aaaaacgcct tgacaagcat ggaccaaacg agctgcaaga agggaaaaaa acttcagcgc 1498861 ttctcttgtt tttcgcgcag ttcaaagatt ttatggtgct tgtgcttctg gcggcaacgt 1498921 taatctcagg atttcttggt gaatatgtag atgcggttgc gattattgcg attgtgtttg 1498981 tgaatggcat actcggtttc tttcaagaaa ggcgtgctga gcaatctctt caggctttaa 1499041 aagagctttc aacaccgcac gtcatggcac tcagggaagg aagctggaca aagattcctt 1499101 ctaaggaact ggtgccgggt gatattgtga aatttacgag cggggacaga attggcgcag 1499161 acgttcgaat tgttgaagcg agaagccttg aaatagaaga atcagcgcta accggggaat 1499221 caatcccggt tgtgaagcat gctgataaat tgaaaaaacc ggatgtttca ctcggcgata 1499281 ttaccaatat ggcatttatg ggtacgattg tgacccgcgg cagcggtgtc ggggttgtcg 1499341 tcgggacagg aatgaatacg gctatgggga aaattgccga catgcttgaa tcggcaggga 1499401 cattgtcaac cccgctgcaa agaagactgg agcagctcgg gaagattttg attgttgttg 1499461 cattgcttct gaccgtactt gtcgttgctg tcggtgttat tcagggtcat gatctgtaca 1499521 gtatgttttt agcaggtgtc tcgttagcgg tagccgctat tccggagggg ctgccggcga 1499581 ttgtgacagt ggcgctttcg cttggtgtac agaggatgat taaacaaaaa tccattgtta 1499641 gaaagcttcc tgctgttgaa acgcttgggt gtgcgtctat catttgctca gataaaacag 1499701 ggacaatgac ccaaaacaaa atgacagtga cgcatgtctg gtccggaggg aaaacatgga 1499761 gagtggcagg ggccggctat gaaccgaaag gaagcttcac actaaacgaa aaagagatca 1499821 gtgtcaatga acataagccg cttcagcaga tgcttctgtt cggagcgctt tgtaacaact 1499881 ccaatattga gaaaagagac ggcgaatatg tgcttgacgg agatccgaca gagggagcgc 1499941 tgctcaccgc ggcaagaaaa ggcggttttt caaaggagtt tgttgaatct aattacagag 1500001 tgattgaaga atttccgttt gattccgcac ggaaaatgat gactgtcatc gtagagaatc 1500061 aagacagaaa gcgctatatc attacaaaag gtgcgccgga tgtactcatg cagcgatctt 1500121 cccgtattta ttatgatggc tcagcggctc ttttttcaaa tgaaagaaaa gcagaaacag 1500181 aggcggtatt aagacatttg gcatcacagg cgctcagaac gatagcggtc gcctacaggc 1500241 cgataaaagc aggcgaaaca ccgtcaatgg agcaggcgga aaaagatctg accatgcttg 1500301 gcctttcagg tatcattgat cccccgcggc cggaagtcag acaggcgatt aaagaatgcc 1500361 gtgaagcggg aattaagacc gtcatgatta caggtgatca tgtagaaacc gctaaagcga 1500421 tagcgaaaga cttgcgcctc cttccgaaaa gcggcaaaat catggacggc aagatgctga 1500481 atgaactttc tcaagaagag ctttctcatg tggtggagga tgtgtatgta tttgcccgcg 1500541 tttcccctga acataaacta aaaatcgtaa aagcctatca ggagaacggg catattgtgg 1500601 cgatgacggg agacggcgtc aatgatgctc ctgccattaa acaggctgat atcggcgtct 1500661 ctatgggcat taccgggaca gatgtggcca aagaagcatc atctcttgtt ctcgtggatg 1500721 ataattttgc gacgattaaa tcagcgataa aagaaggcag gaacatctac gaaaatatca 1500781 ggaagtttat cagatacctg ttggcgtcta acgtcggaga aatccttgtc atgctgtttg 1500841 cgatgctgct tgcccttcct ttaccgctgg ttccgattca gattttgtgg gtcaacttgg 1500901 tgacggacgg attgccggca atggcgctcg gcatggatca gccggaagga gacgtcatga 1500961 agcgcaagcc ccgtcatccg aaagaagggg tatttgcccg caagctagga tggaaggtcg 1501021 tttccagagg atttttaatc ggagttgcca ctattttagc gtttatcatt gtgtaccacc 1501081 gcaatccgga aaacttggct tatgcccaga cgatcgcgtt tgccacattg gtgctcgctc 1501141 agcttattca cgtgtttgac tgccgcagcg aaacttctgt tttctctaga aatccgtttc 1501201 aaaacctgta tttaatcggc gcggtattgt catccatttt gctgatgctt gtagtaatct 1501261 actatccgcc gcttcagccg attttccata ctgtagccat cacgccgggg gactggatgc 1501321 tcgtcatcgg tatgtccgcc atccctactt ttttgctggc ggggtcactt ttaacaagaa 1501381 aaaaataaat tcatatgata taatcttagg ggtaatagcg tgtctattgc ccttttatta 1501441 tgagaacagg gaagaattgg gtgttttaaa atgatacgaa gtatgacagg cttcggcagt 1501501 gcaagcaaaa cacaagacga tctctctgta agcgttgaac ttaaatctgt gaactacaga 1501561 tttaaagaag tgaacgctcg tttgccaagg cctttgctat attttgaaga taagctgaaa 1501621 cagaccattc tgcagcatat tcagcgcgga agaattgagc ttttcgtatc cgttgacagc 1501681 gatatgcttg ttgagaaaag gcttgaaatt gattggccgc tgctcgatga gtttgtcgca 1501741 gccgcgagag atatgaagaa gcggtatcaa ttgtctgcag agcccgatgt aatggatttc 1501801 tttaagcttg atcatgtcgt ccaggttcat gaagaacaga cgcaaaatga caagctggag 1501861 gcgttgatca tcgatgctgc agaagaagcg gtaaaaggtc tctgtgaaat gcgtgaaaaa 1501921 gaggggctgc tcttagcgaa agactgcctg atgcatattg atcagcttga agagctggtg 1501981 agagaaactg aattgctggc tgcagatgtc gtatctcgtt accgggaacg gctgtatgcc 1502041 agaatcaaag aatggactga agacgtatta gacgagagcc ggcttgtaac agaatgcgct 1502101 atttttgcag accgctctga tatcactgaa gagattacaa ggctgaagag ccacttcgcc 1502161 cagtttcgtg atatattagc tagtggcgga gctgtcgggc gcaaactcga ctttcttgtt 1502221 caggagctca atcgggaagc aaatacgatc ggctcaaaag caaatgatca tcagatcaca 1502281 aagcttgtcg ttgaaatgaa aagttctatt gaaaaaataa aagaacaagt gcaaaatata 1502341 gaatagtgac tgtgcgtatt gtttacagac ggtcttacta ggctaaacta gagacgtcta 1502401 ttttacaggg ggaacgtaga agatgacgat taaactgatt aatatcggat ttggcaatat 1502461 catctccgcc aatcggatga tttcgattgt cagcccggag tctgcgccaa tcaaacggat 1502521 gattcaggat gcaagagacc gcggaatgct aattgacgct acatacggac gaagaacccg 1502581 tgcagttgtc gtcatggata gtgatcacat tatcttatct gccgtccagc ctgagacagt 1502641 tgcacacaga ctttctgtta aagaagaaat tatggatgaa gggcaggggt aattgccgca 1502701 tgaaagaaag agggttatta atcgttctct caggtccctc aggagttggt aaaggaacgg 1502761 ttcgacaagc gatcttttcg caggaagaca caaaatttga atattcgatt tcagtaacca 1502821 caagaagtcc aagagagggc gaagtgaacg gagtcgatta ttttttcaaa acaagagacg 1502881 aattcgagca aatgattgcg gacaacaagc tgcttgaatg ggcagagtat gtcggcaatt 1502941 attacggcac gccagtcgat tatgttgaac agacgcttca agatggaaaa gacgtctttt 1503001 tagaaattga agttcaaggg gctcttcaag tgagaaatgc tttcccggaa ggcctgttta 1503061 ttttccttgc gcctccaagc ctttctgaac tgaaaaacag aatcgtgaca cgaggaacag 1503121 aaacagacgc tctgattgaa aatcgaatga aagccgcaaa agctgagatc gaaatgatgg 1503181 atgcttatga ctatgtcgtt gaaaacgata atgtcgaaac ggcttgcgat aaaatcaaag 1503241 caatcgttct tgctgaacat ttgaagcgtg aacgcgttgc accaagatat aagaaaatgc 1503301 tggaggttga ataatcaatg ttagatccgt caattgattc tttaatgaat aaattagatt 1503361 caaaatatac gctggtgact gtttctgcga gacgtgcccg tgaaatgcaa atcaaaaaag 1503421 accaaatgat tgaacatacg atttcacaca aatatgtagg caaagcttta gaagaaattg 1503481 atgcaggcct gctttcgttt gaaaaggaag accgcgaata gtagcacaag tagcaaccta 1503541 tatcatgtag gttgttattt ttttccgtgc ggttttgtaa agtgcagagg gggagaattc 1503601 attgcttaac aatcgaaatg tgttactttg cgtgagtgga ggcatcgctg tttataaagc 1503661 ctgtgcgtta acgagcaagc tggttcaggc aggagcaaat gtcaaagtga ttatgactga 1503721 atccgcttgc cgattcgttt caccgctgac atttcaggca ttgagccgcc acgaagtcta 1503781 tacagataca tttaaagaac aaaatccaag cgtcatttct catattgatg ccgcagactg 1503841 ggccgacttg attatcgtag cgccggctac ggctaatgtg attggaaaac tggcaaacgg 1503901 catcgctgat gatatgctga cgacaacatt gttggcagca acggctcccg tttggatcgc 1503961 gccggcaatg aacgttcata tgtatgacca cccggcagtc aaacgaaaca tttctgttct 1504021 ttatcaggac ggttattgtt ttattgagcc aagtgagggc tatttagcat gcggttacgt 1504081 aggaaaaggc agattggaag agccggaaaa catcgtaaag ctggccgaaa aacattttgc 1504141 tgaagaaaca tccgctcctt tagaaggcaa gcatgtggtc attacagccg gcccaacgcg 1504201 ggaagcgatt gatcctgtcc ggttttttac caataaatcg acgggcaaaa tgggctacgc 1504261 actggcggag gctgctgttc agctcggcgc acgggtaatc ttaatttctg ggcctgtttc 1504321 acttgatcag cctaaaggcc ttgctgagtt tatccctgtt caatcggctg cggatatgcg 1504381 cgaagctgtg ctctctgtgt atgacgcaag cgatatagtc attaaaacag ctgcggtagc 1504441 cgattttacg ccgaaaacag tatttgacca taaaatgaaa aaacaagacg gcggcatgac 1504501 cttagaactg aaaagaacag tcgatatttt gaaagaattg ggcgagaaaa agaaagagca 1504561 gattttggtc ggatttgccg ccgaaacaca agacattgaa cactatgcac gtaaaaagct 1504621 cgccgctaaa aaccttgatt tgattgtggc aaatgatgtg aaagcaaatg gggccggttt 1504681 tggtgctgat acgaatatcg tgacaatctt tttcaaagac gggcataaac gcgaactccc 1504741 gattatgtct aagctcgatg tttcttttga aatccttcag gagatcgcag ccctctcaaa 1504801 acaaaccgga gagcgctcat gaattttgca gaagtcatcg ttgatgtcag caccaaaaat 1504861 atagacaggc cttttgatta taaaatccca gaccatctga agggcatgat caaaacgggg 1504921 atgcgggtca ttgttccgtt tggcccccgt aagattcaag ggtttgtgac agcagtcaaa 1504981 gaagcatctg acctatcggg aaaatctgtc aaggaagtag aggatttatt agatcttaca 1505041 cctgttctga cagaggagct tatgattctg tcatcatggc tgtcagacaa aacgctgtct 1505101 tttaaaataa cggcgcttca agcaatgctg cctgccgcct taaaggcgaa atatgaaaaa 1505161 gaattaaaaa ttgcacacgg agccgatctt ccgccgcaag tggaacggct gttttctgaa 1505221 acaaagacgc tgctgtattc agatataccc gatcatgaga cgctgaaact gattcaaagg 1505281 catgttcaaa aaggggacat tgacgtgacg tataaagtcg cgcaaaaaac caataaaaaa 1505341 atggtcaggc atattcaggc aaatgcgagt aaagaagagc ttgctaagca ggctgaggga 1505401 ttgtcccgcc aagcagcaaa acagcaggcg attcttcact ttctcatctc tgagccggaa 1505461 ggtgtgaaaa ttcctgcggc ggaattgtgc aaaaaaacgg acacgagctc tgcaaccatc 1505521 aaaaccctta tccaaaaagg gcttttgaag gaaagctatg aagaggttta cagagatccc 1505581 tatcaggaca aaatgttcaa aaaaacagag cccctgccgc tgacagacga acagagggct 1505641 gccttcgagc ccatacgcga gacattggac agcgatgagc ataaagtgtt cctccttcac 1505701 ggcgtgacag gaagcggaaa aaccgaaatt tatctgcaat caattgaaaa agtactggcg 1505761 aaaggaaaag aagccatcgt cctcgtaccg gaaatatcgc tgacgccgca aatggtcaac 1505821 cgcttcaagg gccgcttcgg ctcccaggtg gcagtcatgc acagcggttt atccacagga 1505881 gaaaaatatg acgagtggcg taaaatccac cggaaggaag tacggcttgt cgtcggtgcc 1505941 agatccgcca tttttgctcc gtttgaaaat ctcggaatga taatcatcga tgaagagcac 1506001 gagtcttcct ataaacagga agaaatgccg cgctatcatg cgaaagaggt ggcaatcaag 1506061 cgggctgagc atcacagctg cccggttgta ttagggagtg ctacgccgac attagaatca 1506121 tatgctagag cgcaaaaggg cgtatacgag cttctttcac tgaagcaccg tgttaaccat 1506181 cgggtgatgc ccgaggtttc gcttgtcgat atgagagagg agcttagaaa cggcaatcgc 1506241 tcgatgtttt cagttgaatt gatggaaaag cttgaagaaa cgattgccaa gggtgagcag 1506301 gcggtgctgt ttttaaataa gaggggctac tcttcctttg tgatgtgcag ggattgcggc 1506361 tatgtcccgc aatgcccgca ctgcgacatt tccatgacgt atcatcgtta cggccaaagg 1506421 ctgaaatgcc attattgcgg acatgaagag cctgttccgc acacttgtcc tgaatgcgca 1506481 agcgagcata tccgcttttt cggaacggga acacagcgag tggaggaaga gctgacaaaa 1506541 gtgctgccaa gtgcgagagt gattcggatg gatgttgaca cgacatcacg gaaaggcgcc 1506601 catgaaaaat tactgtcagc tttcggagaa ggaaaagcgg atattcttct cggaacgcaa 1506661 atgatcgcga aagggcttga ttttccgaat gtcacgcttg tcggagtgtt aagtgctgat 1506721 acaacacttc atattcctga tttcagatcg gctgaaaaaa catttcagct gttaacgcaa 1506781 gtcagcggcc gggcaggcag gcatgaaaag cccggccatg tcatcattca aacgtataca 1506841 ccgtctcatt acagtatcca gctgacgaaa acacacgatt atgaaacgtt ctatcagcat 1506901 gaaatggcgc acaggagaga gcaatcctat ccgccatact actatttggc tcttgtgact 1506961 gtttctcatg aggaagtggc gaaagcagcg gttacagctg aaaaaatcgc tcattttttg 1507021 aaagcaaact gcggagctga cacgaaaatt ctcggaccaa gcgcgtcgcc gatagccagg 1507081 atcaaagata gatatcgcta tcaatgcgtg ataaaataca aacaggaaac ccagttatcc 1507141 gctttattga agaagatact ggaacattat aaacgcgaaa ttgaacaaaa acatgtaatg 1507201 atttcaattg atatgaatcc ttatatgatg atgtaagatc tcacgtcttg gagggtaaca 1507261 aattggcagt aaaaaaggtc gtcacacatc ctgcggaggt tttggaaaca cctgcggaaa 1507321 ccgtgactgt ttttgataaa aagctaaaaa aactgcttga tgatatgtac gacaccatgc 1507381 ttgaaatgga tggtgtcgga ctggcagcgc cgcaaatcgg cattttaaaa agagcggccg 1507441 tcgtagaaat cggggatgac agagggagaa ttgatctcgt taatcctgaa attttagaaa 1507501 aaagcggcga gcaaaccgga attgaaggat gcttgagctt tcctaacgtc tatggtgatg 1507561 tcacacgtgc cgattatgtc aaagtgcgtg cgtttaaccg tcagggaaaa ccgttcattc 1507621 tggaagcgcg aggcttttta gcaagagccg tgcagcatga aatggaccac ttagacggtg 1507681 tgctgtttac atctaaaata agtaaatact atacagaaga tgaactagcg gatatggaag 1507741 gatgatttga tgacgagaat cgtatttatg ggaacgccgg atttttcagt tcctgtttta 1507801 agaaccctga tagaggacgg atatgaagta gtgggggtcg tcacacagcc ggaccgtccg 1507861 aagggcagaa aaaaagtact gacacctcct ccggtaaagg aagaggcatt gcgccacggc 1507921 atcccggttc ttcagccgga aaaagtcaga ttgacagaag aaattgaaaa agtgctggca 1507981 ttaaagcctg acctgattgt aacggcggca ttcggacaaa ttttgcctaa agagcttctc 1508041 gacagtccaa aatacggctg cattaacgtt cacgcatccc ttttgccgga actgcgcggc 1508101 ggtgctccga tccattattc cattctgcag ggaaagaaga aaaccgggat taccattatg 1508161 tatatggtag aaaaattgga tgcgggcgat atgatctcaa aagtggaagt ggacattgaa 1508221 gaaaccgaca atgtcggaac actgcacgat aaattaagcg ttgctggcgc gaagctattg 1508281 tctgaaacgg ttccaaacgt tattgccggc agcatatcac ctgaaaagca ggatgaagag 1508341 aaagcgacgt acgcgcctaa cattaaaaga gagcaagagc tgctcgactg gtccagaacg 1508401 ggcgaagagc tttacaacca gatccgcggc ttaaatccat ggcctgttgc ttatacgact 1508461 ctaaacggac aaaacttgaa aatatgggcg tcgaaaaaaa tagcggcacc aacaacagct 1508521 gagcccggca cagtcgttgc agttgaaaag gaaggaatta tcgttgccac aggtaacgag 1508581 acggctctgt tattaaccga actccagccg gcaggcaaaa aacgaatgaa aggcgaagac 1508641 tttgtgcgag gcgctcatgt tgaagccggt gatgtgttag gagtaaacaa tgaaaaaaac 1508701 tagtgttcgt gacatcgccc ttgaggcgct gatcaaatta gaacaaaacc aggcatacag 1508761 caacctgctg ctgaaatcgg tcattaaatc aaatgaactg agtgatcaga acagagggct 1508821 tttgactgaa cttgtctatg gtacattaca aaataagatc gcgcttgatt atatgcttaa 1508881 accgtttatc aataagcctc aaaaggtaaa gccgtgggtg attcagcttc ttcgcctatc 1508941 cttatatcaa atggagtatt tggagaagat tccagacagg gcagccattc atgaagcggt 1509001 tgagattgct aaaatccgcg gacacaaagg cattgcttca tttgtcaacg gcgtgctccg 1509061 ttctattcag cgcgaaggtg ttccatcctt tgacgcgatc gaagatcctg tccgccggct 1509121 ggcgacagaa acaagccatc cggaatggct tgtgaaagag tgggcggatg cgtatggatt 1509181 tgaagctgcg gaaaagattt gccgcatcca tctcattccg ccgaaacaga cgctgcgtgt 1509241 caatcaaatg aaagcagaca gagctgagct gcttgaccaa atggctgctg agggaatcga 1509301 agttgaaaaa ggcgacctcg ctgaagatgc tgtgaagctc ttaaagggaa caattgccgg 1509361 aactcatttc ttccaaaacg gcgaagtttc tatccaggat gagagctcca tgctcgtcgc 1509421 ccgcgccctt gatcctaagt cagatgaaac agtgcttgac gcgtgtgcgg cgcctggcgg 1509481 aaagtcggct catatcgcag aattaatgaa gaacaagggg agcgttacgt cgcttgatct 1509541 tcacaaacat aaagtgaagc tgatcaaaga agcggcagat cggcttggcc tgacaatcat 1509601 tcatgcggaa acaatggatg ctagaaaagc gggggaaacg tttgaaaacg aacagtttga 1509661 ccgaatattg gtcgatgccc cgtgctcagg tttcggtgtt atcagaagaa agccggacat 1509721 gaaatacacg aaaaaacctg acgacagcgc ccgtctagct gaaatccagc tgtcgatctt 1509781 gagggaaatc gcaccattag taaaaaaagg tggcactctt gtctacagta cgtgtacaat 1509841 ggaccggaca gaaaatgatg aagtaataca tgcgtttata caagaacatc ctgattttga 1509901 acccgatttg tctcttgaaa agcggctgcc tgaaaaggtg agaccctttg ttcgggatgg 1509961 aaggcttcaa atccttcctc attatttcgg aacagatggt ttctttattt gcagcatgag 1510021 aaagaaggga taagcaatgg cagaacttaa taaaacaaaa gtaagaaaag aattgcggac 1510081 agagcgtccg tctatttatt cttttgaatt agatgaaatc aaacaatggc tgacagacaa 1510141 tggagagaaa ccgttccgtg cagcccagat ctttgaatgg ctatatgaaa aacgcgtatc 1510201 ttcttttgaa gatatgacaa acctctcaaa ggatctgcgt gagaaattaa acactcgctt 1510261 tgtgttaaca acgctgaaaa cggctgttaa acaaacctct caagacggta cgatgaagtt 1510321 tttgtttgag cttcatgacg gttataccat cgaaaccgtt ttaatgagac acgagtatgg 1510381 caattctgta tgtgtaacga cacaagtcgg ctgccgtatt ggctgcacat tctgcgcgtc 1510441 aacgcttgga ggcttaaaac gaaaccttga agcaggggaa attgtcgctc aagtagtcaa 1510501 agtgcaaaaa gctcttgatg aaacggatga acgcgtcagc tctgtcgtga tcatgggaat 1510561 cggcgaacct tttgataact ttaacgaaat gctcgctttc ttgaaaatca ttaaccatga 1510621 caagggcctg aatatcggtg ctcgccatat tacggtctct acgagtggaa tcatcccgaa 1510681 aatttacgaa tttgctgatc agcaaatgca gattaacttt gcaatttctc tgcacgcgcc 1510741 gaacacagaa atcagaagcc gtttgatgcc gattaacaga gcatataaac tgcctgatct 1510801 aatggaagcc gttaaatatt atattaataa aacaggacgc cgtatcagct ttgaatacgg 1510861 gctgttcgga ggcgtaaacg accaggtgga acacgccgaa gagcttgccg acttgctgga 1510921 aggagtcaaa tgccacgtga acttgattcc ggtaaactac gtgcctgaac gggactatgt 1510981 gcgcacaccg cgtgatcaga tttttgcttt tgaaaaaacg ctgaaatccc gcggagtaaa 1511041 tgtcacaatc cgaagagagc aaggacatga cattgacgca gcctgcggtc agcttcgcgc 1511101 gaaggagcgt caagacgaga cgaggtgatg agggttgtta acagccttaa aaacagatac 1511161 aggaaaaatc cgccagcata atgaagatga tgcggggata ttcaagggga aagatgaatt 1511221 tatattagcg gttgtcgctg atggcatggg cggccatctt gctggagatg ttgcgagcaa 1511281 gatggctgtg aaagccatgg gggagaaatg gaatgaagca gagacgattc caactgcgcc 1511341 ctcggaatgt gaaaaatggc tcattgaaca gattctatcg gtaaacagca aaatatacga 1511401 tcacgctcaa gcccacgaag aatgccaagg catggggacg acgattgtat gtgcactttt 1511461 tacggggaaa acggtttctg ttgcccatat cggagacagc agatgctatt tgcttcagga 1511521 cgatgatttc gttcaagtga cagaagacca ttcgcttgta aatgaactgg ttcgcactgg 1511581 agagatttcc agagaagacg ctgaacatca tccgcgaaaa aatgtgttga cgaaggcgct 1511641 tggaacagac cagttagtca gtattgacac ccgttccttt gatatagaac ccggagacaa 1511701 actgcttcta tgttctgacg gactgacaaa taaagtggaa ggcactgagt taaaagacat 1511761 cctgcaaagc gattcagctc ctcaggaaaa agtaaacctg cttgtggaca aagccaatca 1511821 gaatggcgga gaagacaaca ttacagcagt tttgcttgag cttgctttac aagttgaaga 1511881 gggtgaagat cagtgctaat cggcaagcgg atcagcgggc gttaccaaat tctccgcgtc 1511941 ataggcggcg ggggaatggc caacgtgtat ttagctgagg atatcattct agaccgtgaa 1512001 gtcgcaatta aaatcctgcg gtttgactat gcaaatgaca atgaatttat cagacgtttc 1512061 cgcagagaag cccaatccgc atcaagcctc gatcacccga atattgtcag catttatgat 1512121 ttgggcgagg aagatgatat ttattatatt gtcatggaat acgttgaagg catgacgctt 1512181 aaagaataca taacagcaaa tgggccgctt caccctaaag aagcgctgaa catcatggag 1512241 caaattgtct cagccatcgc tcatgcccat caaaaccaga ttgttcacag agacatcaag 1512301 ccgcataaca ttttgattga tcatatggga aatatcaaag taacggattt tggaattgcg 1512361 acggcactaa gttcgaccac aatcacccat accaattcag ttctgggctc ggtccattac 1512421 ttatcacctg aacaggcccg gggcggctta gccacaaaaa aatcggatat ttatgcgctt 1512481 ggaatcgttc tatttgagct tttaaccggc cgtattccgt ttgatggaga gtcagcagtc 1512541 agcatcgcct tgaagcatct tcaagcggaa actccttcgg caaaaaggtg gaatccatcg 1512601 gtcccccaaa gcgttgaaaa catcatactc aaggcaactg ccaaagatcc ttttcatcgc 1512661 tacgaaacgg ctgaagacat ggaagcagac ataaaaacag cttttgatgc cgacagactc 1512721 aatgaaaaga gatttacgat tcaagaagat gaagaaatga caaaagcgat acctatcatt 1512781 aaagatgaag aacttgctaa agctgctggc gaaaaagaag ctgaagtgac aaccgcacaa 1512841 gaaaacaaaa caaagaagaa cggcaaaaga aaaaagtggc cgtgggtttt gctcacgata 1512901 tgcctcgttt ttatcacagc tggaattctt gctgtcactg tttttccgtc gcttttcatg 1512961 cctaaggatg tcaaaatacc tgatgtctcc ggaatggaat acgaaaaagc cgcagggctc 1513021 ttggaaaaag aaggtttaca ggttgattcc gaggtgttgg aaatctcaga tgaaaaaatt 1513081 gaagagggcc tgatggtaaa aacggatcct aaagcggata ccacagtcaa agaaggcgcc 1513141 acggtcaccc tttataagag caccggaaaa gcaaaaacgg agatcggtga tgtgacaggc 1513201 caaacggtcg accaagcaaa aaaagcgttg aaggaccaag ggtttaatca tgtaacagta 1513261 aatgaagtga atgacgagaa aaatgcgggc actgtcattg accaaaatcc ttcagcaggg 1513321 actgagctgg tcccgagtga agatcaagtc aaacttacag tcagtatcgg acccgaagac 1513381 attacgctta gagacttgaa aacctacagt aaagaagcag cgtctggata tctggaagac 1513441 aacggattga agcttgtaga aaaagaagca tactcagatg atgttccaga aggacaggtt 1513501 gtcaaacaaa aaccagcagc aggtacggca gtaaagccgg gaaacgaagt tgaagtgaca 1513561 ttctctctcg gaccagagaa aaaacctgcg aaaacagtga aagaaaaggt caagatcccc 1513621 tacgaaccag aaaatgaagg ggacgagctt caagtgcaaa tcgcggttga cgatgcggat 1513681 cacagcatct ctgacactta cgaagaattt aagataaaag agccgactga acgaacgatc 1513741 gaactaaaga ttgaaccagg ccaaaaaggg tactatcaag taatggtaaa caataaagtt 1513801 gtcagctaca aaaccattga gtatccgaaa gatgaataac aaggagggaa aatatgcctg 1513861 agggcaaaat tattaaggcg ctaagcggct tttactatgt actggatgaa tcagaggatt 1513921 cagataaagt aatacaatgc agaggaagag gcattttcag aaaaaacaaa attacccctc 1513981 ttgtcggtga ttacgttgtg tatcaagctg aaaatgacaa agaaggatat ctaatggaaa 1514041 ttaaagaaag aaccaacgag cttatcaggc cgccaatttg caacgttgat caagcggtcc 1514101 ttgttttctc agcggttcag ccttctttca gcacggcatt gctcgaccgc ttcctggttc 1514161 tcgttgaggc caatgatatt cagccgatta tatgcattac taaaatggat ctgattgaag 1514221 atcaagatac agaagatacg atacaagcct atgcagaaga ctatcggaat attggttatg 1514281 acgtatacct tacctcctct aaggaccaag atagtttagc ggacatcatc ccgcattttc 1514341 aggataaaac aacggtattt gccggtcagt ccggtgttgg gaaatcctcg cttctcaacg 1514401 cgatcagtcc ggagctcgga ttaagaacaa acgagatttc cgagcatttg ggccgcggga 1514461 aacacacaac ccgccacgtg gagctgattc acacgtccgg aggtttggtt gcagatacac 1514521 cgggattcag ctcgcttgaa tttacagaca ttgaggaaga agagctgggc tataccttcc 1514581 ctgatatcag agaaaaaagc tcttcatgca aatttagagg ctgtttacat ctgaaagagc 1514641 cgaaatgtgc ggtgaaacaa gctgttgaag acggggaatt aaagcagtat cgctatgacc 1514701 attatgttga atttatgacg gagattaaag acagaaagcc gaggtattag cataatgata 1514761 aaggttgcac catctattct ttccgctgat tttgccgctt taggcaatga gattaaagat 1514821 gtagaaaaag gcggagccga ttgtattcat attgatgtta tggacggcca ttttgtcccg 1514881 aatatcacaa tcggtccgct gattgtagaa gcggtccggc cggtaacgga tctgccgctt 1514941 gatgtccatt taatgataga agagccggat cgttatatcc cggcttttgc gaaagcaggc 1515001 gcagatatcc tgtctgtgca tgctgaggca tgtccgcacc tgcaccgtac catccagctc 1515061 attaaagagc aaggagtgaa ggccggagta gttctaaacc cgcatacccc tgtacaagtc 1515121 atcgaacatg ttttcgacga tcttgatctt gttcttttaa tgacggtgaa cccgggcttc 1515181 ggcgggcaga aatttattca ttcagtcctt cctaaaataa aagaggttaa gcgaatggcg 1515241 gatgaaaaag gaaaaaaaga tctgttaatt gaagtagacg gcggcgtcaa caaagaaacc 1515301 gctccgctcg tcattgaagc gggcgcaaat ttactcgttg ccggttcagc tgtttatggc 1515361 cagtctgacc gcaaaaaagc aatttctgaa atcagaggaa gtaaataagc agctttagaa 1515421 aagagctggg catacaatag cctaagctct ttttcctgta tgcagagaaa ggaatcagag 1515481 atgaaaacaa ttaatatcgt tgcgggaggc ccgaaaaatc tcattcccga tctaaccggc 1515541 tatacggatg aacacacgct ttggatcggt gttgacaaag gcaccgtcac tctcttagat 1515601 gccgggatca ttcctgttga agccttcgga gattttgaca gcataacgga gcaagaacgc 1515661 cggcgaatag aaaaagccgc tcccgccctt catgtgtatc aagcagaaaa agatcaaaca 1515721 gatttagacc tcgcccttga ttgggcgctg gaaaagcagc cggatattat tcagattttc 1515781 ggcattacag gcggcagagc tgatcatttt ttaggaaaca ttcagcttct gtataaaggt 1515841 gtaaaaacga acataaaaat taggctgata gacaaacaaa atcatattca aatgttccct 1515901 cctggtgaat atgatattga gaaggatgaa aataagcgat atatctcctt cataccgttt 1515961 tccgaagaca tacatgagct gaccctgacc ggttttaaat atcctctaaa taattgtcat 1516021 attacgctcg gttcaacact atgtattagt aacgaactca ttcattcacg aggtactttt 1516081 tcgtttgcaa aaggcatatt aataatgata agaagcacgg attaagcatg tgctttcatt 1516141 caattgctga aaacaatgaa caaggcggtt acgggacgtt ataggagggg acaaaaatga 1516201 aattttacac cattaaattg ccgaagtttt taggaggaat tgtccgggcg atgctgggct 1516261 catttagaaa agattaatgc ccaggggttc aaagccctct ttcaccacat aaaaacgcct 1516321 gccacatatc ggggcaggcg ttcattttgt tatacacgct caactttacc ggatttcaaa 1516381 gctcgagcag atacatatac ttttttaggt tttccgttca caaggatacg aaccttttga 1516441 agattcgcgc cccaagtgcg cttagaagcg ttcattgcgt gagaacggtt attcccagct 1516501 gttgtttttt tacctgtgat aacgcattta cgtgccattt gtttccctcc tcacttgcac 1516561 aaaacatcta ctttttaaca ttcatataat cttagatgct ttcgatatgg atactttaaa 1516621 taatttacca cagctaaaaa acgtttgcaa ctattgtttc atcatctttc aagaaaattc 1516681 acttgacatc ttgcggaaac agcagcgcta tagtatatgt agaggtacgg ccagcgatta 1516741 ttgcctggtc ttttcataat ggaaaccata tagtagaata gctgtaactc tatgcattcg 1516801 aaggaggaac tagtgtgtcc attgaattaa gaacgaagta cggacagatt gatatatcta 1516861 atgaagtcat cgcgatggtt gcaggaggcg cggcggttga ctgttacggc attgtcggca 1516921 tggcctctaa aaaccagatt aaagacggac tgactgaaat ccttcggaaa gagaatttca 1516981 gcaggggtgt ccaagttcgc caagaaggag aacagataca tatcgacatg tatatcattg 1517041 tcagctacgg cacgaaaatt tctgaagtgg cacataatgt ccaaacaaaa gtaaagtaca 1517101 cagtaaatca aaccatcgga ctggcagtgg attctgtcaa tatttatgtc caaggcgtac 1517161 gagtgacgaa cccgtagtta ggaggagtag gattgtctat cagaacatta gacggcagaa 1517221 cctttgccga gatgattctt gcgggagcgc agaatctgtc tcaaaacgcc agtgcagttg 1517281 atgcactgaa cgtgttcccg gtgccggacg gtgatacggg aacaaatatg aacctgtcga 1517341 tgacttccgg agcaagagaa gttgaacaaa tggatacgga tgatatcggg aaggtgggct 1517401 ccgcgttatc taaagggctg ctcatgggag cacgcggaaa ttcaggagtt atcctatccc 1517461 aattgttccg cggatttagc aaaaacattg aaacgaaaaa agaaattaat gcacttgagt 1517521 ttgccgctgc gctgcaagca ggtgtagaca tggcgtataa agctgtcatg aaacctgtag 1517581 agggcaccat tttaacagtt gcaaaagacg ctgcaaaaaa agcaatgatc ttagcagaaa 1517641 aagaaaccga tatcactgcg ctgatgactg cagtgacaga agaagcagag gcgtctttaa 1517701 accgcacccc tgaattgcta cctgtcctaa aggaagtagg agttgtcgat agcgggggca 1517761 aaggcctgct ctgtgtgtat gaaggtttcc ttgcttcatt aaaaggtgaa actgtacctc 1517821 agaaagcagt tcttccgtca cttgacgaca tggtcagcgc agagcatcac aagagcgcgc 1517881 aaagcatgat gaataccgaa gatattgaat ttggattctg taccgaagtg atggttaggc 1517941 ttgatcagac aaaaagagag ttcgacgaag gcacgttcag gcaagacctc agccagttcg 1518001 gagattctct gcttgtgatt gcggatgaat cgctggcgaa ggttcatatt catgctgaag 1518061 agccgggaaa cgtgttaaac tacgcccagc attacggtga attgatcaaa ataaaaatag 1518121 aaaatatgag agaacagcat acctctatca tcagtcaaga aagcaaacct gcagacaacg 1518181 aaacaccgcc ggcaaaacag ccgtatggca ttgtgactgt agcgatggga gaaggaattg 1518241 cagacctatt taaaagcatt ggcgcttctg ttgtgattga aggcggccag accatgaacc 1518301 caagcactga ggatattgtt gatgccgtga agtctgtaaa tgcagatacg gtatttatcc 1518361 tgcctaacaa ctccaacatt atcatggctg ctaaccaagc ggccagcgta gtggatgaac 1518421 aggtttttgt cattcctgct aaaacggttc cgcaagggat gtcagctctg ctggctttta 1518481 acccggatca agaagctgaa gcgaacgagg ccaatatgct aagcgccatt cagcaagtaa 1518541 aaagcggaca ggtgacgttc tcagtcagag atactcatat tgacggtaaa gacattaaaa 1518601 aaggcgactt tatgggcatt ctgaatggaa cgattatcgg cacttctgaa aatcagctgt 1518661 cagccgcgaa aatgctgctg tcagaaatga tcggagaaga tgatgaaatc gtgaccattc 1518721 tatatggtga ggatgcgtct caggaagaag ctgagcagct tgaagcgttt ctcagtgaaa 1518781 agtacgagga gattgaggtt gagatccaca atgggaaaca gcctctgtat tcgtatatag 1518841 tttcagcaga atagaagggc aatttgccct tctattctta tgtctgcttt taagtgcggc 1518901 agcgctgtaa cgcgcccgct tgccatttta tatctgatca attagtctag aagcaaagcg 1518961 ctaataagct ctggttcata aggaggaata gcatgaaata cagaagcgtt tttgatatta 1519021 tcggcccggt tatgatcggt ccgtccagct ctcatacagc gggagctgct agaatcggga 1519081 gagtggccag aagtttattt ggcagagagc ctgagcgcat cattgtatct ttttacggct 1519141 cgtttgcgga aacgtataag ggccacggca cagatgtcgc gattatcggc ggattgcttg 1519201 attttgatac attcgatgaa cggattaaaa ccgctataca aattgcagaa gctaaaggaa 1519261 ttgatataga gtttcgggta gaagacgcag tcccggtcca cccgaacaca gcaaaaatca 1519321 ccatttctga tgaaaagggt gagctggaac tgacgggtat ttcgattggc ggaggaaaga 1519381 ttgaaatcac agaattgaat ggttttgagc tccggctgtc aggaaatcat ccggccatat 1519441 tagttgttca taatgacaag tttggcacaa ttgccggtgt tgccaatgtt ctggcgaaat 1519501 tttcaatcaa cgtaggacat atggaagtag cccggaaaga tatcggccag cttgcgctga 1519561 tgacaataga ggtcgatcaa aatattgacg accacattct cgacgagctg tcgaagctgc 1519621 cgaatattat tcaagtgaca aagattgctg actagcgaaa agggtcagga ggagccagtt 1519681 atgtttcgta atgtaaaaga attaattgag attactaaag aaaaacaaat attgatctct 1519741 gatgtgatga tagctcaaga gatggaagta acagaaaaaa caaaagagga catttttcag 1519801 cagatggatc ataacctgtc tgttatggaa gcggcggttc agaaaggact cgagggagtt 1519861 acgagccaaa cgggcttaac aggcggagat gccgttaaat tgcaggccta tattcgatca 1519921 ggaaaaagcc tgtctggccc gctgatttta gatgctgtat cgaaagccgt tgcaacaaat 1519981 gaagtaaatg cagccatggg aaccatctgt gcgacaccga ctgcaggttc tgccggtgtg 1520041 gtgcccggta cgttatttgc tgtaaaagaa aagctgaatc caacaagaga acaaatgatc 1520101 cgctttttgt ttacagccgg ggctttcgga tttgtcgtgg ccaataacgc aagcatttcc 1520161 ggcgccgccg gaggatgtca ggcagaggtt ggatcagctt caggcatggc ggctgcggct 1520221 attgttgaaa tggcaggagg aacacccgaa caaagcgcgg aagccatggc cattacatta 1520281 aaaaatatgc taggcctcgt gtgcgaccct gttgcagggc ttgttgaggt gccttgcgtg 1520341 aaacggaatg cgatgggcgc gtcaaatgcg atgattgctg ctgatatggc attggcgggc 1520401 attacaagcc gtattccatg tgatgaggtt atcgatgcca tgtataaaat aggccaaacg 1520461 atgccaactg cacttagaga aacaggccag ggcggtttag cggcaacacc gacaggaaga 1520521 gaattagaga aaaaaatttt cggaggagcg ctaggttcac gtgaaacaac atcagcaaac 1520581 tagtatagct aacattaagg gtattgggcc ggaaacagaa aaaacattga atgaactcgg 1520641 tatttatgac atttctgatc ttctgaatta tttcccttat cgctatgatg actacgagct 1520701 gagggattta gaagaagtaa agcatgatga aagagtcaca gtcgaaggga aggttcattc 1520761 agagccttct cttacctatt acggaaaaaa acgaaacagg ctgacattca ggcttctggt 1520821 cggccactat ttaatcacag ccgtatgttt taaccggcct tatttgaaga agaagctttc 1520881 gctcggctct gtggtgacgg tttcaggtaa atgggacaag caccgccaaa ccatctctgt 1520941 tcaggagttg aaaaacgggc cgcatcaaga agacaaaagc attgaaccag tgtattctgt 1521001 gaaagaaaat gttaccgtca aaatgatgag gcgctttatt cagcaggcgc tgacccaata 1521061 tgcagactca cttcctgatc ctcttccgga aaagctaaga aaaagctata aactgcctga 1521121 ctattatcaa gcgttaaaag caatgcacca gcctgaaaca agggaagcat taaagcttgc 1521181 cagacggcgg tttgtttatg aagaattttt gttgtttcag ttgaaaatgc aggcgttccg 1521241 aaaggcggaa agagagcaga cacaagggat acggcagcgt ttttcaaacg aagaactcat 1521301 gagatttatc aaaagcctcc cgtttcccct cacaaacgcc cagtcacgcg ttcttcgcga 1521361 aataacagca gacatgtctt ctccatacag aatgaaccgt cttcttcaag gggacgttgg 1521421 atcaggaaaa acggcagtcg ccgccattgc actgtatgcc gcgatcctat ccggatacca 1521481 aggagcgctc atggtgccga cagaaattct ggccgagcag catgctgatt cgctcgtttc 1521541 gctatttgaa aaatgggacg tcagcgttgc tcttttgaca agctctgtta aaggaaagcg 1521601 gcgaaaagaa ctgcttgagc gtcttgcggc gggtgagatt gatattcttg taggaaccca 1521661 tgctttaatc caagacgagg tggagtttaa ggcgttgagt ctcgttatta ctgatgaaca 1521721 gcacagattt ggagttgagc agcgcaaaaa gcttcggaac aaagggcagg atcccgatgt 1521781 tctctttatg acagccactc caatcccaag aacattagcg atcacagtat tcggtgaaat 1521841 ggatgtatct gtcattgatg agatgccggc tggacgaaag cgaattgaaa cctattgggt 1521901 aaaacatgac atgcttgatc gtattttggc atttgtcgaa aaagaattaa agcaaggcag 1521961 gcaggcttat atcatctgtc cgctgattga agaatcagat aagcttgatg tgcaaaacgc 1522021 cattgacgtg tacaatatgc tttctgatat ttttcgggga aaatggaatg tcggccttat 1522081 gcatggaaag ctgcattccg atgaaaaaga tcaggtcatg agagaattca gcgcaaatca 1522141 ctgtcaaatt ctcgtatcaa ccactgttgt ggaggttggc gtaaatgttc cgaatgcaac 1522201 aattatggtg atttatgacg ccgaccgttt cggactatca cagcttcacc agctgcgcgg 1522261 ccgtgttgga cggggtgagc atcaatcttt ctgtattctg atggctgatc caaaatcaga 1522321 aacagggaaa gaacggatga ggatcatgtc ggagaccaat gacggtttcg agctgtctga 1522381 aaaggatctg gaactgagag gtcccggtga tttcttcggg aaaaaacaaa gcggaatgcc 1522441 ggaatttaaa gtggcggaca tggttcatga ttacagagcg cttgaaacgg caaggcagga 1522501 tgctgcgaat cttgtggctt ctgacgcgtt ctggaaggag ccggaatacg ctgtgttaag 1522561 agatgaattg ctgaagagcg gagtaatgga cggggaaaaa ttaagctgag tatcagaagt 1522621 ttttggtgtt cagccagaaa caatcgttgc attccaatct atgaaattat atactactat 1522681 tagtacctag tcttaattgt ccggatggtg tttagatatg agaagaaata agagagaacg 1522741 ccaggaatta cttcagcaga cgattcaagc aacccccttt attacagatg aagaactagc 1522801 gggtaaattc ggggtgagca tccagacgat acgtttggac cgcttagagc tttccatacc 1522861 tgaactgaga gaaagaatta agaacgtggc agagaaaaca cttgaggacg aagtgaagtc 1522921 cctgtcactt gatgaagtta tcggagaaat tattgacctt gagctggatg atcaggcgat 1522981 atccatttta gaaataaaac aggagcacgt gttcagccgg aatcagattg cgagaggaca 1523041 ccatttattt gcacaggcga attctttggc cgttgcagtc attgatgacg agctggcgct 1523101 gactgcaagt gcagacatcc gctttacaag acaggtaaag cagggtgaac gtgtcgtagc 1523161 aaaagcgaaa gtgacggctg tcgaaaaaga aaaaggaaga acggttgtcg aagtgaacag 1523221 ctacgttggc gaagaaattg ttttttctgg acgctttgac atgtatcgtt caaaacattc 1523281 ataaaggtgg agcatgcatg agaatagctg tagatgcaat gggaggagac cacgctccca 1523341 aagctgttat tgacggagtt ataaaaggta tagaggcatt tgatgatctc catatcacac 1523401 ttgtcggtga caaaacaacg atagaatcac atttaacaac tacatcagat cgcatcacgg 1523461 tgctgcacgc agatgaagtg attgagccta cggatgaacc ggtccgtgcc gtgcgaagaa 1523521 aaaagaactc atctatggtt cttatggcgc aggaggttgc ggaaaacaga gctgacgcct 1523581 gcatttcagc gggaaatacc ggtgcattaa tgacagccgg tctctttatt gtcgggagaa 1523641 ttaaaggaat tgaccgtccg gcgcttgctc cgacacttcc gactgtttcg ggagacggat 1523701 ttcttctcct tgatgtcggc gccaatgtcg atgccaaacc ggagcacctc gttcaatatg 1523761 ccatcatggg ttctgtttat tctcagcaag tgcgcggtgt cacttcaccg agagtcggac 1523821 ttttaaatgt cggaacagaa gataaaaaag gaaacgaact gacgaagcag acgtttcaaa 1523881 ttttaaaaga aacagcaaac atcaatttta tcggaaacgt ggaagcgcga gaccttttag 1523941 atgatgtggc ggatgttgta gtaacagacg gctttaccgg gaatgttaca ctcaaaacgc 1524001 tggaaggctc tgcgttgtca atttttaaaa tgatgagaga cgtaatgacg tctactttga 1524061 catccaagct tgcagcagct gtgctgaaac caaaattgaa agaaatgaaa atgaaaatgg 1524121 agtattcgaa ttatggcgga gcaagtcttt ttggcttaaa agcgcctgtg atcaaggcgc 1524181 acggctcttc agattcaaat gctgtattcc atgcgattcg gcaagcaaga gagatggtca 1524241 gccaaaatgt ggctgcgctc attcaggaag aagtgaaaga agaaaaaaca gatgagtagt 1524301 ctggaggttt ttacatcatg agtaagattg catttttatt cccgggtcag ggatcacaat 1524361 ttatcggcat gggaaaagag ctttatgagc aggtgcctgc tgcaaagcgt ctgtttgatg 1524421 aagccgatga aacgttggaa acaaaactca gctcgcttat ttttgagggg gatgctgaag 1524481 aattaacact tacatacaat gcgcagcctg ctttgcttac gacaagcatc gctgttcttg 1524541 agaaatttaa agaatctggc attacacctg atttcacagc aggacacagc cttggtgaat 1524601 attctgcact ggttgcggct ggcgctctgt ctttcaaaga tgctgtttat actgtcagaa 1524661 agcgcggaga gtttatgaat gaagcggtgc cggctggcga aggagcaatg gctgcgattc 1524721 tcggcatgga tgctgaagca ttaaagcaag taaccgataa agtcacagag gaaggcaacc 1524781 ttgtacagct tgcgaatctc aactgtcctg gccaaatcgt catttccgga acagctaaag 1524841 gggttgagct tgcatctgaa ctggcaaaag agaacggcgc aaaacgcgca attccgcttg 1524901 aagtaagcgg tccgttccat tctgaactga tgaaaccggc tgctgaaaag ctgaaagagg 1524961 tattggacgc ctgtgacata aaagacgctg acgttccggt catctcaaat gtttctgctg 1525021 acgtgatgac tgaaaaagca gatatcaaag aaaaacttat tgagcagctt tactctccgg 1525081 ttcgttttga ggaaagcatt aacaagctga tcgcagaggg tgttacgact tttattgaaa 1525141 tcggtcccgg aaaagtgctt tcaggccttg tgaaaaaagt gaatagacgg ttaaaaacaa 1525201 ttgctgtatc agatccggaa acgatcgagc tggcaattca aacgcttaag gaggagaatg 1525261 ataatgctta atgataaaac ggctattgtc actggcgcat cccgcggaat cggccgctca 1525321 atcgcccttg atctggcaaa aagcggagca aatgttgtcg tgaactactc cggcaatgaa 1525381 gcgaaagcaa atgaagtggt agatgaaatc aaatcaatgg gcagaaaagc aattgctgta 1525441 aaagcggatg tatcaaatcc cgaagatgta caaaacatga taaaagaaac attgtctgtt 1525501 ttttctacga ttgacattct ggttaataat gcgggaatta caagagacaa tctcatcatg 1525561 agaatgaaag aagacgaatg ggatgacgtc attaacatta acctgaaggg tgttttcaac 1525621 tgcacaaaag ctgttacaag acaaatgatg aaacagcgtt caggccgcat tattaacgta 1525681 tcgtctatcg tcggcgtcag cggaaaccct ggacaagcca actacgtggc tgcaaaagcc 1525741 ggcgtcatcg gtttaaccaa atcttctgct aaagagctcg ccagccgaaa tattacggta 1525801 aacgcaatag cgccaggatt tatctcaact gatatgacag ataaacttgc aaaagacgtt 1525861 caagacgaaa tgctgaaaca aattccgctc gcgcgctttg gtgaacctag cgatgtcagc 1525921 agtgttgtca cgttcctagc ttcagaggga gctcgttata tgacaggcca aacgcttcat 1525981 attgacggcg gaatggtgat gtaagttttt tctcgaaaat ttcatcgtag tttctctagt 1526041 tttttaaaaa cgaatccact ataatacttg aggggaggtg aattgctatg gcagacacat 1526101 tagagcgtgt aacgaaaatc atcgtagatc gccttggcgt tgatgaagca gacgtcaaac 1526161 ttgaagcttc tttcaaggaa gacttaggtg ctgattccct agatgtagtt gagcttgtta 1526221 tggaacttga agacgagttt gatatggaga tttctgacga agatgctgaa aagattgcaa 1526281 cagtcggcga cgctgtgaac tacatacaaa accagcaata agctgatgct aaaagtcccg 1526341 ccgaaacgcg gggctttagc cctttattcg tgcagttatt acagcatgcc gcttttacgc 1526401 gcgctgtatc cggtttagtc agagaagcgc ggtgaacctg atgtgcctat ggaggttact 1526461 atgtcaaaac actcacatta taaagataaa aaaaagttct ataaaaaagt agaacaattt 1526521 aaagagtttc aagaacggat ttcggttcac tttcaaaatg aaaagctttt gtatcaagca 1526581 tttacacatt catcttatgt gaatgagcat cggaaaaagc cgtatgaaga taatgaaagg 1526641 cttgaatttt taggtgacgc tgttttggaa ctgacgatct ccagattctt atttgccaaa 1526701 tacccggcta tgagtgaagg agatttgacg aaattgagag ccgcaattgt ttgcgaaccg 1526761 tctctcgttt cattggctca cgagctgtca ttcggcgatc ttgtcctgtt gggtaaaggc 1526821 gaggaaatga caggcggaag aaagcgtcct gctctattgg cggatgtttt tgaggcattt 1526881 atcggagcct tgtaccttga ccaaggatta gagccggtcg aaagtttctt aaaagtttat 1526941 gtgttcccta aaattaacga tggtgctttt tctcatgtga tggatttcaa aagccagctg 1527001 caggaatacg tgcagcggga cggcaaaggc tctctggagt ataaaatctc caacgaaaaa 1527061 ggacctgcgc acaaccgtga atttgaagcc atcgtatctc taaaaggtga accactcgga 1527121 gtcggaaacg gccgttcaaa gaaagaagcc gaacagcacg ctgctcagga agctttagct 1527181 aaattgcaaa aacaccatac gaaacaataa aatccccctt atgactcagg gggatttcag 1527241 tatgtatgcc gtcttatttg accaatgttt atgatagaat tgaaatactt attacataag 1527301 gaggatcgct atgttcctca aacgtttaga cgttatagga tttaaatcat ttgcagaacg 1527361 gatttccgta gacttcgtta aaggcgtgac agcagttgtc gggccgaacg gaagcggaaa 1527421 aagcaacatc acggatgcca ttcgctgggt tctcggcgaa caatcggcac gctctcttcg 1527481 cggcggaaaa atggaagaca tcatttttgc tgggagtgat tcaagaaagc gattaaatct 1527541 agctgaagtt acgcttactc ttgataatga tgatcatttc ttgccaattg acttccacga 1527601 ggtgagtgtc acaagacgtg tgtacagatc aggtgagagt gagtttctga ttaacaatca 1527661 gccatgccgc ttgaaagata ttattgattt atttatggac tctgggcttg gtaaagaagc 1527721 attttctatt atcagccaag ggaaagtgga agagatcctg agcagcaaag cggaggatcg 1527781 ccgcagtatc tttgaagaag cggccggggt gcttaaatat aaaacgagaa agaaaaaagc 1527841 agaaaataaa ctgtttgaga cacaggacaa tctaaatcgg gtagaagata tattacatga 1527901 gcttgaagga caggttgaac ctcttaaaat tcaagcttca atagcgaaag actaccttga 1527961 gaaaaagaaa gagctggagc atgttgaaat tgcgctgact gcctatgata tcgaagagct 1528021 gcatggtaaa tggtcgactc ttaaagagaa agtgcagatg gcaaaagaag aagagcttgc 1528081 tgaatcgtct gctatttctg cgaaagaagc aaagattgag gatacaaggg acaaaataca 1528141 agcgcttgat gagtcagtag atgagctcca gcaagtttta ctggtaacta gtgaagagct 1528201 ggaaaagctt gaaggccgta aagaagtcct gaaagaacga aagaaaaacg ctgtgcaaaa 1528261 ccaagaacag cttgaagaag ccatcgttca gttccagcaa aaagaaacgg ttctgaaaga 1528321 agagctttcg aagcaggaag ctgtcttcga aacgcttcag gctgaggtga agcagttaag 1528381 ggcgcaagta aaagaaaaac agcaggctct cagtcttcac aatgaaaatg tcgaagagaa 1528441 aatcgagcag ctgaaaagtg attattttga gctgttaaac agccaggctt cgatacgcaa 1528501 cgaactccag cttcttgatg accagatgtc ccaatccgct gtcacattgc agagacttgc 1528561 ggacaacaat gaaaagcacc tgcaggaacg gcatgatatt tctgcgcgta aagccgcatg 1528621 tgaaacggaa tttgcccgaa ttgagcagga gattcacagt caagtcggtg catatcgtga 1528681 tatgcagaca aaatatgagc agaaaaagcg ccaatacgaa aaaaatgaat ccgctctgta 1528741 tcaggcatac caatacgttc agcaagcgag atcaaaaaag gacatgcttg agacgatgca 1528801 gggagatttc tccggctttt atcaaggtgt taaagaagtg ctgaaagcga aagagcgcct 1528861 tggcggaatt cgcggagcgg ttcttgagct gatttctaca gaacagaagt atgaaacggc 1528921 cattgaaata gcgctcggcg cttctgctca acacgtcgtg accgacgatg aacaatctgc 1528981 ccgcaaagcg attcaatatt taaagcagaa ttccttcggc cgggcgacgt ttctgcctct 1529041 ttctgttatt agagaccgcc agcttcaaag ccgtgacgcg gaaacagccg cccggcattc 1529101 atcatttctc ggggttgcca gtgaacttgt cacatttgat cctgcgtatc gaagcgtcat 1529161 ccagaatctt cttggaaccg ttctgatcac agaggactta aagggtgcaa acgagcttgc 1529221 gaagcttctc gggcaccggt accgcatcgt aacccttgag ggagatgttg tgaaccccgg 1529281 tggttcaatg acgggcggcg cggttaaaaa gaaaaataac tccctccttg gaagaagccg 1529341 ggagctagaa gatgtgacga aacggctcgc tgaaatggaa gagaaaacgg cactgcttga 1529401 acaagaggtc aaaaccctta agcactccat tcaggatatg gagaaaaaac tggctgactt 1529461 aagagaaacc ggggaaggct taaggttaaa gcagcaggat gtgaaaggcc agctgtacga 1529521 acttcaagtt gccgagaaaa atatcaatac ccatttagag ctctatgatc aagaaaaatc 1529581 tgctctgtca gaaagcgatg aagagagaaa agtgcgcaaa cgcaagcttg aagaagagct 1529641 ctctgccgta tctgaaaaga tgaaacagct tgaagaggac atagacagac tgacaaaaca 1529701 aaaacaaacg caatcctcaa cgaaagagtc tctctccaac gagctgactg agctgaagat 1529761 cgcagcggcc aaaaaagagc aggcttgcaa gggggaagag gacaaccttg ccagattaaa 1529821 gaaagagctc actgaaacag agcttgcgtt aaaagaagca aaagaagact taagcttctt 1529881 aacgtcagag atgtcatcta gcaccagcgg cgaagaaaag ctggaagaag cagcaaaaca 1529941 taaattgaat gacaaaacga aaacgatcga actgattgca ttaaggcgcg atcagcgcat 1530001 caagcttcag catgggcttg atacgtatga gcgtgagctg aaagaaatga aacgcctgta 1530061 taaacaaaaa acaacgctct taaaagacga agaagtcaaa cttggacgaa tggaagtcga 1530121 gcttgataat ttactccaat acttacggga ggaatacagc ttgtcctttg agggggcaaa 1530181 agagaaatat cagcttgaaa ctgatccaga ggaagccaga aagcgcgtga agctgattaa 1530241 actcgcaatt gaagagctgg gtaccgtgaa cctcggaagc atagatgagt ttgagagggt 1530301 caacgaacgg tacaagtttc tgtcggaaca aaaagaagat ttaacagaag cgaaaaatac 1530361 cttgttccaa gtgattgaag aaatggatga agaaatgacg aagcgcttta acgacacatt 1530421 cgtccaaatc cgctcacact ttgatcaagt tttccgctcc ttattcggag gagggcgagc 1530481 tgaactgagg ctcaccgatc ctaacgatct gcttcattca ggagtcgaga ttatcgctca 1530541 gccgccgggg aaaaagctgc aaaacttaaa cctcctgtca ggcggagagc gtgcgcttac 1530601 tgctatagcg ctcttattct caatcctaaa ggttcgtcca gtgccgtttt gcgtccttga 1530661 cgaagtagag gctgcgctcg acgaagcgaa tgtgttccga tttgcgcagt atttaaaaaa 1530721 atacagcagc gatactcagt ttattgtgat tacccacaga aaaggaacga tggaggaagc 1530781 ggatgtgctt tatggcgtaa ccatgcagga atccggtgtt tccaaggtaa tttcagttaa 1530841 gctggaagaa acaaaagaat tcgttcagta acgaggaaag aggttaaaag atgagctttt 1530901 ttaaaaaatt aaaagagaaa atcacaaaac agacagattc cgtatctgaa aagtttaagg 1530961 atggccttga aaaaacaaga aactcctttc aaaacaaagt gaatgatctt gtatcccgtt 1531021 accgtaaagt ggatgaggat ttcttcgaag agcttgaaga ggttcttatc agcgcggatg 1531081 tcggttttac aaccgttatg gaattaatag atgagctgaa aaaagaagtc aaacgcagaa 1531141 atattcaaga tccaaaggaa gtccagtcag tgatttctga gaaactggtc gagatttata 1531201 acagcggaga tgagcaaatt tcagaactga acatccagga tgggcgttta aacgtaatcc 1531261 ttctggtagg tgtaaacggc gtcgggaaaa caacaacgat cggaaagctt gctcataaaa 1531321 tgaaacaaga aggaaaatct gttgtacttg ccgccggaga cacttttaga gcgggagcca 1531381 ttgaacagct ggaagtatgg ggagagcgta caggagtgcc tgtcattaag cagacggcag 1531441 gaagcgatcc ggcggctgtc atctacgatg ctgttcatgc tgcgaaagca agaaatgccg 1531501 atgtattaat ttgtgatacg gcagggcgtc tccaaaacaa agtaaatctc atgaaagagc 1531561 ttgaaaaagt aaaacgtgtt atcgaaagag aagttcctga agctccgcat gaggtgctgc 1531621 ttgcccttga tgccacgacc ggccaaaatg caatggctca ggcaaaagaa ttctctaaag 1531681 caacaaatgt taccggcatt gctttaacga agcttgacgg tacggcaaaa ggcggtatcg 1531741 tccttgcgat tcgcaacgag cttcacatcc cggttaaact agtcggttta ggagaaaaag 1531801 ttgatgacct tcaggaattt gatccagaat cctatgtgta cggactcttt tcagatttag 1531861 tggaaaaagc cgacgattaa gaaaaaggcc ccaacatctt ggggcctttt tcttttttat 1531921 cttcttactt gataggcgaa atgataaagg ctgttatcag tggataccag tcttgactca 1531981 ccagaaaaaa ctctgaatgg gatgatgtca tagtaatgaa cggaaacaga tgtgtaatac 1532041 gtatagtaac cagcagctgg ccccaaatac attggaacct caaatgttcc gtttgcatca 1532101 gtcgttcctg aagcagtttg tgttgtgttt ccgaccttcg tgtccgcttc aaatcttacg 1532161 ggcgcgtttg gcactggctg tccgttttgg tcgagtaatt tgccgcttac tgtaatattg 1532221 tacttgactc gccaatattg accttgtccg taattgattt taccgtatac ccctccatct 1532281 gtgctgatat ttgtgattga ggccttataa ggtgcctcag cagcgtctgc ttgctgtgcc 1532341 gggaaaccta ttgtaaacag ggctgccaga cataacataa acaataaacc gatttttttc 1532401 ataaaaatcc tccttaaaat agggttcata tacaatatcg gaataaattg gatgatattt 1532461 agcgtatttt ggaaaagtta atcgccgctt tgacaagata aaaacttgac agtgtcatta 1532521 aaaccgtgta aactaagtta tcgtaaaggg atttgactta acaaagggga gagctcaaat 1532581 gtcactcgaa aagacaacga gaatgaatta tctgtttgat ttttatcagt cgttgttgac 1532641 gtcaaaacag aagagctata tgtcgcttta ttatttggac gatttctccc taggcgaaat 1532701 agccgaagaa tatgaggttt caagacaagc tgtttatgat aacatcaaac gaacagaagc 1532761 aatgcttgaa caatatgaag aaaagctgct ccttttgaaa aagtttcagg agcgtaaaga 1532821 gatgtttaat aagctgaagg agcttgcttc cggttcaaaa gaagaggaag aaattacagc 1532881 tctgattgaa gcgcttgaga aattagatta ggaggcggca aactatggca tttgaaggat 1532941 tagccgaccg actgcagcag acgatttcta aaatccgcgg aaaagggaaa gtcagcgaac 1533001 aagatgtaaa agagatgatg cgtgaggtcc gtcttgcgct gcttgaggct gacgttaact 1533061 ttaaagtagt caaggatttt gtcaaaaaag taagtgaacg cgctgtaggc caagacgtca 1533121 tgaaaagtct gacgcccggc cagcaggtca ttaaagttgt tcaagaggaa ctgactgagc 1533181 tgatgggcgg cgaagagagc aaaatcgccg tcgcaaaaag gccgccgact gttattatga 1533241 tggtcggtct ccaaggtgcc ggtaaaacga caacaagcgg taagcttgcg aatctgctgc 1533301 gcaaaaagca taatcgcaaa ccgatgctgg ttgctgccga tatttaccgc ccagccgcaa 1533361 ttaagcagct ggaaacactc ggcaaacagc ttgatatgcc tgttttctct cttggcgatc 1533421 aggtcagtcc tgtagaaata gctaaacagg ctattgagaa agccaaggaa gaacattatg 1533481 actacgtcat tttggatacg gcagggcgct tgcatatcga ccatgaactg atggatgaac 1533541 tgaccaacgt caaagaaatc gcgaatccgg aagaaatttt cctggttgtc gattcaatga 1533601 ccggtcagga cgctgtgaat gttgccaaaa gctttaatga acagctcggt ttaaccggtg 1533661 ttgtgttgac taagctggat ggagacacac gcggcggggc tgcgctttct attcgcgctg 1533721 tcacaaacac gccaattaag tttgcaggtt tgggcgaaaa gcttgatgcg ttagagccgt 1533781 tccatcctga acgcatggca tcaaggattc tcggcatggg cgacgtgctg acattgattg 1533841 aaaaagcaca ggccagcgtt gatgaagaca aagccaaaga gctggaacaa aaaatgagaa 1533901 cgatgagctt cacattggac gattttctgg agcagctcgg gcaagtcaga aacatggggc 1533961 cgcttgatga gcttctgcaa atgatgccgg gtgcaggtaa aatgaagggc ctgaaaaaca 1534021 tccaagttga tgaaaaacag ctgaatcatg tggaagcaat catcaaatca atgactgttc 1534081 ttgaaaaaga acagccggat attatcaatg ccagccggcg gaagcggatt gcaaaaggaa 1534141 gcgggacatc cgtacaggaa gtcaaccgtc tgcttaagca gtttgatgaa atgaaaaaaa 1534201 tgatgaagca gatgacaaac atgtcaaaag gcaagaaaaa agggtttaag ctacctttta 1534261 tgtaatcggt tatacatgat aaaaccgttg ttaagaaaaa acactttaca aacactttta 1534321 tcattgttaa tatactatct tgttgaaata ttttcggagg tgctagtaaa atggcagtaa 1534381 aaattcgttt aaaacgtatg ggagcaaaaa aatctccttt ctatcgtatt gttgtagcag 1534441 attctcgttc accacgtgac ggccgtttca tcgaaacagt cggaacttac aacccggttg 1534501 caaaaccagc ggaagtaaaa attgacgaag agcttgctct taaatggctt caaactggag 1534561 cgaaaccatc tgatacagtt cgcaacttgt tctctagcca aggaatcatg gaaaaattcc 1534621 acaacgctaa acaaggcaag taatgactga tcaacacttg gaagatttga ttgtccacat 1534681 tgtgacgccg cttgttgatc atccagatga cattcgcgtc ataagagaag aaaccgatca 1534741 aaagattgcg ctgcgcttat ctgtccataa gtcagatacc ggtaaagtta tcggaaagca 1534801 aggccggact gcaaaagcga ttcgaacagc tgtatttgca gctggcgtac agtcttctaa 1534861 gaaagttcaa tttgaaatat ttgactaaaa gggagagggc cggcacctcc ccttttttta 1534921 cacgcaaaaa aagggtaaac tgatagaagc ttaggcaaaa tagaaaagcc tggacgagta 1534981 aaagttttaa aagcggggag cttggtgcga tgcaaattat tcaccgtgta gccgttatgc 1535041 aagtcttaac cgagcgcagt aaagaaaagc ttttagcttc ttttgctgag aagaaacaaa 1535101 tgcttgaacg agaatgcagc cagctctatt ttcagcttag aaaacatgag aaagaacagc 1535161 aaaaccctaa tatgattgaa caatttaaaa aggcaataga aaagcgaaaa gatgatataa 1535221 aaatcattga ttttcaaatt gctcaagtac atacattgcc gcttggcagt gagttgaaag 1535281 aaaaggaagt cgatgcgctg ctgacgattg aagccgggga tgactggcat gagaaaacag 1535341 cagcgaacac catcgtcata aaagacggaa aagtaattga aattcgccag aggtgatcat 1535401 atgacaaagc gatggtttaa tgtaggcaaa atcgtaaata cccacggaat caaaggcgaa 1535461 gtgcgggtga tttcaaaaac agattttgcc gaagaacgat acaagccggg aaacacgctg 1535521 tatttgttta tggacggccg taacgaacca gtggaggtaa cggtaaacac acatagactg 1535581 cataagcaat ttcatctcct gcagtttaaa gaaagacaaa acctaaatga agtagaagag 1535641 ctgaaaaacg caatcattaa agttcctgaa gaagaattag gagagctgaa tgagggtgaa 1535701 ttttatttcc acgaaattat tgggtgtgaa gtatttactg aagaaggcga actcatcgga 1535761 aaggtcaaag aaattttgac gcctggagcc aatgacgttt gggtcatcgg acgaaaagga 1535821 aaaaaagacg cactcattcc ttacattgaa tcagtggtta aacatatcga tgtcagggaa 1535881 aagaaaattg agattgaact catggaaggg ttaatagacg aatgaaaatc gattttttga 1535941 cgctgtttcc cgaaatgttt gaaggcgtgc tcggctcatc gattcttcaa aaagcccagg 1536001 aaaaagatgc ggtgcagttt caagtcgtaa atttccgaga gtactctgat aacaagcaca 1536061 atactgttga tgattatcct tatggcggcg gggcaggcat ggttctcaag ccccagcctg 1536121 tttttgacgc ggtcgaggac ctgacatcaa aggcagccgc tgctccgcgt attatcctcg 1536181 tatgcccgca aggtgagcgt tttacccaaa aaaaagccga acaattagct aaggaagagc 1536241 atttgctgtt catttgcggc cactatgaag gctatgatga acgcattcgc gagcacttgg 1536301 taacggatga aatatcaatt ggcgactttg ttctgacggg cggtgagctc cctgcaatga 1536361 tgatcgcaga cagtgtggtc agactgcttc cgggtgtact gggtaaagag gcttcccata 1536421 ttgaggattc cttcagcacc ggacttttag agcacccgca ttatacaaga ccggcagatt 1536481 acaaaggttt aaaagtgcct gaaacactct tgtcaggaaa ccatgcaaaa attgaagaat 1536541 ggcggaataa agaatcgatc agaaggacct acctaagacg tccggatctg ttgaaagacc 1536601 acccgcttac agagcagcaa agaaagtgga tttctgaatg ggaaaaagaa tagattttat 1536661 tgcataggct atgaaattgt gataagatac tacttgtggc ttaagcgggc ttatccgctg 1536721 caagcttgaa aacgatgttc cgctgtgccg gtttttgtgg ccaagagcat ctgttggaag 1536781 gagttgaaaa cgatgcaaaa actaattgaa gatatcacaa aagaacagct tcgtactgat 1536841 cttcctgcgt tccgtcctgg tgacacttta cgtgtacacg ttaaagttgt tgagggtaac 1536901 cgtgagcgta tccagatctt tgaaggtgtt gtgattaagc gtcgtggtgg tggaatcagc 1536961 gaaacgttca cagttcgtaa gatttcttac ggtgttggcg ttgaacgtac tttcccagta 1537021 cacacaccaa aaatcgcgaa aatcgaagtt gtacgttacg gtaaagtacg ccgtgctaaa 1537081 ctttactacc tgcgtgaact tcgcggaaaa gcggctcgta ttaaagagat cagacgataa 1537141 tgataacgaa cgaaaagagc ttgttacctg taacaagctc tttttttata cagaatttga 1537201 aaatgccgga caggcatcgt aaaatacata aaggacaaca atgaatcatg catactgaag 1537261 ataaaggcgg tgttcgtgtc acatgacaat tcaatggttc ccgggccata tggcaaaagc 1537321 aagaagggaa gtaaccgaaa aattaaaatt aatcgatatc gtatatgaat tggtagatgc 1537381 cagaattcca atgtcatcaa gaaacccaat gattgaagat attctaaaaa acaagccgcg 1537441 aattatgctg ttaaacaagg ctgacaaagc agatgcggca gttacacagc agtggaaaga 1537501 gcactttgag aaccagggga tccgctctct gtctattaat tctgtaaatg gacaagggtt 1537561 aaatcaaatt gtgcctgcat caaaagagat cctccaagaa aaatttgacc ggatgcgtgc 1537621 gaaaggtgtg aagccgagag cgattcgcgc tttgattatc ggcattccaa acgtcggaaa 1537681 atcaacgctc atcaaccggc ttgcaaagaa aaacatagca aaaacgggag acagacctgg 1537741 tattacgact tctcaacagt gggtcaaagt tgggaaagaa ttagagctat tagatacacc 1537801 gggaattttg tggcctaaat ttgaggatga gcttgtcggt ttgagactgg cagtcaccgg 1537861 ggctattaaa gactcgatta tcaatttgca ggacgtggcc gtgtttggtc ttcgttttct 1537921 cgaagaacat tacccagaac ggcttaaaga gcgttatggc cttgatgaga tcccagagga 1537981 cattgccgag ctgtttgatg caataggtga aaagcggggc tgtctcatga gcggtgggct 1538041 catcaactac gataagacga ctgaagtcat cattcgcgat attcgcactg aaaagttcgg 1538101 caggctgtca tttgaacagc cgacgatgta aaggcgcgca gaaatgcggg tctttatttt 1538161 ttcttggctg aaccgataca tacagtaagg gagaagagaa agtgaataca ttaaccgtaa 1538221 aggacattaa agaccgtttg caggaagtga aggatgcaca agacccattt attgcccaat 1538281 gcgaaaacga cccgagaaaa agcgttcaaa cgcttgtaga gcaatggctt aaaaagcaag 1538341 cgaaagaaaa agcgctgaaa gaacaatggg tgaatatgac ttcctatgaa aggctggcaa 1538401 gaaacaaagg atttcgcttg attgcaggtg ttgacgaggt cggccggggg ccattggcag 1538461 gaccagttgt cgccagcgca gtcatccttc cagaggaatg tgaaatactt gggctgacag 1538521 actccaaaaa gctttcagag aaaaaacgcg aggaatatta cgagcttatt atgaaggaag 1538581 cactggcggt cgggatagga attgtagaag ctactgtgat tgatgagatc aatatatatg 1538641 aagcttcaaa aatggcaatg gtgaaagcga tacaggattt gtcggataca cctgattatt 1538701 tgcttgttga cgcaatgaca cttccgctcg acacggctca ggcgtcaatt ataaaaggcg 1538761 atgccaaaag cgtgtctatt gcggcaggtg cgtgtatcgc aaaagtgacg agggaccgaa 1538821 tgatgagcgc ttatgccgaa acgtatccca tgtacggctt tgaaaaaaat aaaggctatg 1538881 ggacaaaaga acatttggaa gctctcgctg catacggccc aactgaattg caccgcaaaa 1538941 ctttcgctcc tgttcaatct ttcagataaa tcaccatgga caaggaggca cctttttaaa 1539001 atgaacatac gaaatgatgt gcaaaaggcg ctgcagcacc ttttcgggcg tacagccgtc 1539061 ccgcaggaaa catcaaaagt aaacgaagcg ctaaacgggg agaagcgtct cctcttagga 1539121 aaagtgcttc gtttactagg agatcagcat gccctgatcc aagtcggcaa tcaaactgtt 1539181 cagggaaaac ttgaaactca gcttcgtcct caggcatact attggttttc ctacgaaaaa 1539241 aaaacggcag agcaaacagg ccgtcttcag gtcgttcaaa gctttgatca aaatcctaaa 1539301 accattcagg atgcagctgg caaactttta aatgctattt cagtgaagac gtcaaacgca 1539361 gctctcatga tgacaggagc gatgctgaaa agcaaaacac ccgtaacaga aaatgatatc 1539421 aaaacagctg tccgctggat ggacacgctg ccttcgcaag acacaaaaaa agcagttgaa 1539481 acggttctct tcgctttaaa gcgtgatctt cccattcact ccgagatttt gaatggtgtt 1539541 cacgctgtga aatcgcctgt tccgttgcat cagcacgtat cccagctgct acaggcaatc 1539601 gaccaaaacc ctcagcagag ccaaatgatg tcaaagctaa aggaagcagt cacggtgctt 1539661 ttaaatagtg aaatcgatgt ccatgcagaa cggctgattg ataagcttat ttctttaacc 1539721 gacaatacga aagcaccttc tccgacgaat acagctggaa gcagggagct tagcacacca 1539781 gctggctccc ccggaaaagc cagcctgccg attgcaaatc acacagcaga acagggaagc 1539841 atacaagaag agcctgttaa aacagcagca gacattccaa ttaaagaagc ccgccagctg 1539901 ctggtgaagc tgacggaatc tgctgaaaaa aacagtctcc aaattgtgaa agaagcagca 1539961 aattggatta aagcggctgc ttcatcgggt gatagtaagt cacttgcagc ttcagctgtt 1540021 ttacaggcgg cacaagtcac agatcaggaa gccgaagtct ttttaaaggc tgttcagcag 1540081 acagcacccc atttggcgga taaggcagat gttctttctt tcttatccaa agtgaaaacg 1540141 gcaatcggcg caagggacga ggttgcgttc attaaagcgt ttgaacaagg aagcgcagtc 1540201 acatctggcg aaatgcaatc catcaagctg gctctttctg ccttaagagc atcgcatgag 1540261 gtagccgaac cagtcaaaca agaagccgat cagctttttc ataaattaaa tggccagctt 1540321 ttcatgcagc aggaccatcc atcatacagc caaattgtaa tgtcatttcc gatgttttcg 1540381 aagtcagggg ttcaggacat gactgttctg tttaaaggaa agaaagaagc ggatggaaag 1540441 cttgatcctt cccattgccg ccttttgttt ttgctgcagc ttgatacact aaaagaaacc 1540501 gtcgttgatt gcttggtaca gcaaaaagtc atgaccatta caatagagac tgatttcgag 1540561 ctgcaggctg cgatcgatcc gatggtgccc gcgcttaaac aggggctaaa ggaaatgggg 1540621 tacagccttt caggggtaaa cgctaaaaaa agggttcaca ccgaagaaaa ggcttcaatc 1540681 gatcaatata taacaagtat cagtgatcag gaagtggatg tgaaaatatg aaagagcaga 1540741 caccgatcag aaaagctgtt gctctccatt atgacgaaca aaaagacaag gcgccgagag 1540801 tgattgccac agggaagggc catgtagctg acaacattat aaaagaagcg aaaaaagcag 1540861 gggtcccgat tcaagaagat cggacccttg tcgaattaat gcgccatttg acggtagatg 1540921 atcaaattcc tgaagctctt tatgaaacgg tagccgagat tttttcattc atttacaaat 1540981 tggacgaaag cgtaaaaaac aaaaaatagc taaaatattc cccatccttc tttgaaattt 1541041 atgtttttaa taaagtaaaa gtttgaatgt ttagaaggat taaaagattt tgcatcgaac 1541101 tgtagacaat tcttccagta ttattataga atgaaagcgc agtctatttt agttttgtta 1541161 cataagttag gaggatggga aatgaatatc catgagtacc agggaaaaga agtcctcaga 1541221 aaatatgggg tatctgttcc tgaaggtaaa gtggctttta cagcagaaga agcagttgag 1541281 agtgcaaaga gcttatccag ctcggtttat gtcgtaaagg ctcaaattca tgctggcggt 1541341 cgaggcaaag ctggtggggt aaaaatagca aaatcattag acgaagtaaa agcgtatgcc 1541401 gaagaactat tagggaagac cctagttaca catcagacgg gtccggacgg ccaagtaata 1541461 aaacgcttac ttattgaaga aggctgcgat attaaaaaag aatattacat cggtctagtg 1541521 cttgaccgcg ccacttcaag aatcgtttta atggcttctg aagaaggcgg aacggaaatt 1541581 gaagaggttg cggagaaaac accagaaaaa atcaaaaaag ctgtcattga tccagctgtt 1541641 ggccttcaag gctatcaagc cagagaaatt gcattcgcta ttaatattcc aaaagagctc 1541701 gtgggaaaag ctgctaaatt tatgcttgga ctatataaag cgtttgttga gaaagactgc 1541761 tcaatcgccg aaatcaatcc gcttgttgtg actggcgacg gaaatgtgat ggcgcttgat 1541821 gcaaaattga attttgacag caatgcgttg taccgacaaa aggacattat ggaatacaga 1541881 gatttggatg aagaagatcc gaaagaaatt gaagcgtcca aatatgatct aagctacatt 1541941 tcccttgatg gaaatatcgg ctgtatggta aacggcgcgg gacttgcaat gtctacgatg 1542001 gatattatca agcattatgg aggagaaccg gccaacttcc ttgatgtggg cggcggtgca 1542061 accgcggaaa aagtcacgga agcatttaaa atcattcttt ctgatcaaaa cgttaaaggg 1542121 atttttgtca acattttcgg cggcattatg aaatgtgatg tcatcgcaga aggggttgtt 1542181 gaagcgacta gacaagttgg tttgacattg ccgcttgtcg tccgtcttga aggcacaaac 1542241 gtggatctag ggaagaaaat ccttagtgaa tcaggattaa acattacatc tgcggaatca 1542301 atggctgacg gcgcgcagaa aatcgtatcc ttagtttaag aaagaatgaa aggcagggga 1542361 ccaaataatg agtgttttca ttaataaaga tacaagagtt attgtgcaag ggattacagg 1542421 ttctaccgct ttatttcata cgaagcagat gcttgaatac ggcacaaata tcgttggcgg 1542481 tgtaacacct ggaaaaggcg gaacagaagc ggaaggtgtt cctgtattta atacagtggc 1542541 tgaagcagtt caaacaaccg gcgctaacgc gtctgttata tatgtgcccg caccgtttgc 1542601 agctgatgcg attatggaag cggtagatgc ggagcttgat ctcgtgattt gtatcacaga 1542661 acatatcccg gttttggata tggtgaaggt caaacgcttc atggaaggca agaaaacgag 1542721 actgataggg ccgaactgtc ctggtgtcat tacgcctgaa gaatgtaaaa tcggcattat 1542781 gcccggatac atccataaaa agggtcatgt aggcgttgta tcacgttcag gaacattaac 1542841 atacgaagcg gtgcaccagc tctcagaagc gggtgtaggg caatctacag ctgttggaat 1542901 cggcggcgac cctgtaaatg gaacaaactt tattgacgtt ttaaaagcgt ttaacgaaga 1542961 tcctgacaca cacgcagtca tcatgattgg cgaaatcggc ggtacggccg aagaggaagc 1543021 ggcagagtgg gtaaaagcca acatgacaaa accggtagtc ggttttattg gcggtaaaac 1543081 agcacctcct gggaagcgca tggggcatgc aggcgccatt atttccggcg ggaaagggac 1543141 agctgatgaa aaaatcaaaa cccttaatgc atgcggaatc gaagttgcag agacaccttc 1543201 tgtcatgggt gaaaccttaa tcaaggtgct gaaagagaag aacttgttcg aaacttgtaa 1543261 aacgcattaa taaaaaaggg acagccgtca aggctgttcc tgctttttct aacaaaagga 1543321 ggtcaatcta ttggatcagg ccgctgtctg cctaacgatt tgcagaatca atcaattatt 1543381 atccccatcc cttctattaa aatggtggaa agccgatccg tctatgtcgc tgacatcacc 1543441 cgtgttacaa acggttactc gtgatcaaat aaaagcagct gcattaaaaa acgaaataga 1543501 acaattttat ccaaagctcc cgcgtgtact tgctgcttat cgtgagcaag gcattaacac 1543561 catccctatt tcttcaaagc aatatccttt ctggcttaaa agcatttatg atccccctgc 1543621 cgtactgttt gcaaaaggtg atatgactct tctttcgaaa gggagaaaaa ttggaattgt 1543681 aggcacaaga aatccaacag cttatgggaa acaagttgtc aatcatctta caaaagagat 1543741 ctgtcgtaaa ggttgggtga ttgtcagcgg actggcgtct gggatagacg gaatgtccca 1543801 tgctgcaagt attaaggcga aggggcggac aattggcgtc attgcaggcg gatttcaaca 1543861 catttatccc cgagaaaacc ttcagttagc agatcacatg gctaaacacc atatcctgct 1543921 gtcagagcac ccacctgaaa ctaaacccca aaaatggcat ttccctatga gaaaccgtat 1543981 tatcagcgga ctaagtgaag gcgttattgt cgttcagggc aaagaaaaaa gcggttcgct 1544041 gattactgcc tatcaagcat tggaacaagg gagagaggta tttgccgtac ccggttcatt 1544101 gtttgaccct tacgccggag gtcctataaa actgatccag cagggggcta aagccatatg 1544161 gtcagcagag gatattttcg aggaacttcc tgagagaaac gttcaatata cggaaccctt 1544221 ttgaattatc gtttgacaaa cggtattgta atatttaata atagtgagga tttaaagttg 1544281 catattgttt tctatttaat taatgacgtt catgataaag aatgaaatgt tgaaagccaa 1544341 ataaagacag ctgcaaaaat aaaattgaaa tatcttgaaa agagagagaa cacctcttga 1544401 gggggatgaa aatgtctgat tatctagtca tcgtggaatc gcccgctaag gcgaaaacga 1544461 ttgaacgtta cttaggtaaa aaatataaag taaaagcatc aatgggacat gtccgggatc 1544521 ttccaaaaag tcaaatggga gttgacatag aacagaattt tgaaccgaaa tatattacca 1544581 ttcgaggtaa aggcccggta ttaaaagagc tgaaaacggc tgcgaaaaaa gccaaaaaag 1544641 tgtatctcgc agctgacccc gacagagaag gggaagcgat tgcatggcat ttggcacaca 1544701 gtcttgattt agatctcaac tcagactgcc gtgtggtgtt taacgaaatt acaaaagacg 1544761 ctattaagga atcgtttaag catccccgca tgatcaatat ggatttagtg gatgcacagc 1544821 aagcgagacg tattttagac aggcttgtcg gatataaaat cagtccaatc ttatggaaaa 1544881 aagtcaaaaa agggcttagc gcaggacgcg tgcaatccgt tgccctccgt ttgattattg 1544941 accgtgaaaa agagattaac gactttaagc ctgaggaata ttggacaatt gacggtacgt 1545001 tcttaaaagg tcaagaaacc tttgaagcga gctttttcgg gaaaaacggc aaaaaacttc 1545061 ctttaaatag tgaagctgat gtaaaagaga ttctttctca gctcaaaggg aatcaatata 1545121 cagttgaaaa agtaaccaaa aaggaacgca aacgtaatcc tgctttgcct tttaccactt 1545181 ctaccctgca gcaggaagcg gctcgcaagc tcaatttcag agcgaagaaa acgatgatga 1545241 ttgcacagca attatatgaa ggaattgatt taggaagaga aggaacggtt ggtctgatca 1545301 cgtatatgag aacggattca acccgtattt caaatacggc tgttgatgaa gcagctgcat 1545361 ttattgatca gacatatgga aaagagttcc taggcggaaa acggaagcct gcgaaaaaga 1545421 atgaaaatgc ccaggatgcc cacgaagcaa ttcggccgac atcagttctt agaaaaccaa 1545481 gtgaattaaa agcagtcctc ggcagagacc aaatgagact gtataaatta atttgggagc 1545541 gttttgttgc cagccaaatg gcaccggctg ttctcgatac aatgagtgtc gacctgacaa 1545601 acaacggttt gacatttcgt gcaaatggaa gtaaagtcaa gttttccggg tttatgaagg 1545661 tgtatgttga aggaaaagac gatcaaatgg aagaaaaaga ccggatgctg cctgacttac 1545721 aagaaggcga cacggtatta tcaaaagata tagaacctga gcagcatttt acccagccgc 1545781 ctccgcgata tactgaggcc cggcttgtta aaacccttga agaacgcggt atcggccgtc 1545841 catccacata tgctccgaca cttgatacta ttcagcggcg cggctacgtg gcattggata 1545901 ataaacgttt cgttccgact gaattaggtc agatcgttct tgacttgatc atggagtttt 1545961 tccctgagat cattaacgtt gagtttacag ctaaaatgga gagagatctt gatcatgttg 1546021 aagaaggaaa taccgaatgg gtcaagatta tcgataattt ctacaccgat tttgaaaaac 1546081 gcgtcaaaaa agccgaatcg gaaatgaagg aagttgagat tgaaccagag tatgctggag 1546141 aggattgtga attgtgcagt tctccaatgg tatataaaat gggacggtac ggtaaattct 1546201 tagcttgctc caacttccct gactgccgga acacgaaacc gattgtgaaa caaatcggtg 1546261 tgaagtgccc gagctgcgga gaaggaaaca ttgttgagcg aaaatcgaaa aagaaacggg 1546321 tgttttacgg ctgtgaccgt tatccggact gtgaattcgt atcatgggac aaaccaattg 1546381 aacgaaaatg cccgaaatgc ggaaaaatgc tcgtcgagaa aaaactcaaa aaaggtatac 1546441 aagtccaatg cgtggaatgc gattataagg aagaaccaca gaagtagcgg tgagcagggt 1546501 cttgctcacc ttctttgtgt gttaaaagaa ggccttgaat aataaactag gagatgtgaa 1546561 agatgaacca acaaacagtg aatgtaatcg gagccggact cgcaggaagt gaagcagcat 1546621 ggcagcttgc caaacgtggg attcaagtca aattgtatga aatgcggcca gttaaacaaa 1546681 cgcctgcgca tcatacagat aaatttgctg agcttgtctg cagcaactct cttcgctcta 1546741 atacacttgc taacgctgtc ggtgtattaa aggaagaaat gcgtgcgctt gattcagcca 1546801 ttatcgctgc ggctgacgaa tgttcggtgc ctgccggggg cgctcttgca gtagaccgtc 1546861 atgaatttgc cgcaagtgtg acaaatcggg tgaaaaatca tccaaacgta accgttatta 1546921 atgaagaagt gactgaaatt cctgaaggcc ctactatcat cgcaacgggt ccgttaacat 1546981 ctgaatcgct gtctgcccag ctgaaggagc tgactggaga ggactattta tatttttatg 1547041 acgcagcggc gccaattgta gaaaaagaca gccttgatat ggataaagtg tacctgaaat 1547101 cccgttatga taaaggtgaa gcagcatatt tgaactgccc gatgacagaa gaagagtttg 1547161 accgttttca tgaagcatta acatcagcag aaacagtgcc gttaaaagaa tttgaaaaag 1547221 agattttctt tgaaggctgc atgccgattg aagtcatggc aaaacggggt aagaaaacaa 1547281 tgcttttcgg tccgatgaaa ccagttggtc tagagcatcc tgttacagga aaacgccctt 1547341 atgccgtcgt tcagctcaga caggatgatg ctgcgggaac actttataat attgtaggat 1547401 tccagacaca tttaaaatgg ggagaccaaa aggaagttct caagttgatt ccaggacttg 1547461 aaaatgtaga aatcgtcaga tatggcgtga tgcatagaaa cacatttatt aactctccaa 1547521 gcctgttaaa gccgacttat caatttaaaa accgcagtga tctgttcttt gcaggccaaa 1547581 tgacgggagt agaaggatat gtggaatcag ctgcctcagg acttgtagca ggcattaatg 1547641 cggcgaagct tgtattggga gaagagcttg tgatcttccc tcaggaaaca gcaattggca 1547701 gtatggcaca ttatattaca acaacaaacc agaagaactt ccagccgatg aatgcaaact 1547761 ttgggctttt gaaagaattg ccagttaaaa ttaaaaataa aaaagaacga aatgaacaat 1547821 acgcgaaccg tgcgattgaa acaattcaaa caatttcgaa aacaatatag gtattgattg 1547881 caacctgagc gcgatttgtg ataccattta aaagcccttc ctggggaggt attaggcatg 1547941 gagaatgtta agaatttcgt aaagttattc gttgaatatt tacaaattga aaaaaattat 1548001 tcacaatata ctattgtgaa ttatgtggat tcaattgaag aattcgagac tttcctgcgc 1548061 gttcaaggta taaatggatt tgaagaagct gcatatcaag atactaggat ttttttgaca 1548121 gaagcctatg aaaaaggttt atcgagaaga acaataagca aaaagatatc tgcattaaga 1548181 agcttttata agtttctgat gcgggaaaag cttattgaag aaaatccgtt tcagcttgtt 1548241 catctgccaa aacaggagaa acggataccg aagtttctat atcaaaaaga gcttgaggag 1548301 ctgtttgaag tttcagatat aagccagccg gccggaatga gggatcaagc gctgttagag 1548361 ctgctctatg ccactggaat gagggtcagt gaatgctgtt ccataactat taacgacgtt 1548421 gatttattta tggacactgt gcttgttcac ggtaaaggca agaagcagcg ctatatcccc 1548481 tttgggtctt atgcccgcga agcgttgaag gtatacatga atagcggaag acagtgcttg 1548541 ctgatgaagg caaaagaacc tcatgatcta ttattcgtaa atcaaagagg cggaccgctt 1548601 acagcccgtg gcatcagaca tattttaagc gggcttgttc aaaaagcgtc aagcacttta 1548661 catatccatc cgcatatgct tcgacatacg ttcgccacgc atctgttaaa tgaaggagcg 1548721 gatttgagaa gcgttcaaga actgctcggg cattccaatc tgtcttctac acagatatac 1548781 acgcacgttt cgaaggaaat gttgagaaac acatatatgt ctcaccatcc aagagcattt 1548841 aagaaaaatt aaaggaggcc ctttatgtca tcttttcatg cgaccacaat atttgccgta 1548901 cagcataaag gacgaagcgc tatgtccgga gacggccaag taacatttgg tcaggctgtt 1548961 gtcatgaaac acacggcacg gaaagtgaga aaactgttta acggcaaagt tcttgctggt 1549021 tttgcgggat ctgttgcaga cgctttcact ttattcgaaa agtttgaagc taagcttgaa 1549081 gaatataacg gcaacttaaa acgggcggct gttgagcttg caaaggaatg gcgcagtgat 1549141 aaagtgctaa gaaagctcga agccatgctg attgttatga atcaggatac tttgcttctc 1549201 gtatcgggaa caggcgaggt gatcgaacca gatgacggca ttctcgcgat tggatcagga 1549261 ggcaattacg ctttggcagc gggaagagca ctgaaaaagc atgccgggga aagcatgtct 1549321 gcaagtgaga ttgccagagc cgcgttagaa acagcaggcg aaatttgtgt ttacacgaac 1549381 gatcaaatca tactggaaga gcttgaatag aaaggacttg aggcgcatgg aaaaaaaacc 1549441 gttaactcct agacagattg tagatcggtt agaccaatat attgtcggtc agcaaaatgc 1549501 gaaaaaagct gtcgccgtgg cattaagaaa ccgctataga agaagtcttc tggatgaaaa 1549561 gctgaaggac gaggtcgttc cgaaaaacat tttaatgatg ggtcctaccg gcgtcgggaa 1549621 aactgaaatt gccagacgaa tcgctaagct ttcaggtgcg ccatttatca aaattgaagc 1549681 tactaaattt accgaagtcg gctatgtagg cagagatgtt gaatcaatgg tcagagatct 1549741 tgtggagact tctgttcggc ttataaaaga agagaaaatg aatgaagtaa aggaacaggc 1549801 agaagaaaat gcaaacaaac gcattgttcg tctgttagtt cctgggaaga aaaaacaatc 1549861 tggtgttaaa aatccgtttg aaatgttttt tggaggcagc cagccgaatg gtgaagatga 1549921 ggcggagagc caggaagaag caaacatcga agaaaaaaga aaacgaatgg cgcatcagct 1549981 ggctttagga gagctcgaag actactatgt aacagtagaa gtcgaagaac agcagccttc 1550041 tatgtttgac atgctgcagg gctcgggtat ggagcagatg ggtatgaaca tgcaggatgc 1550101 gctgagcgga ttaatgccaa agaaaaagaa gcggcgcaaa atgacagtca gagaagccag 1550161 aaaagtcctg acgaatgaag aagcaagcaa actcatcgat atggatgaag tcggccagga 1550221 agctgttcag agagcagaag agagcgggat tatctttatc gatgagattg ataaaatcgc 1550281 aaagaacggc ggtgcatctt cttctgccga tgtttcaaga gaaggtgttc agcgggatat 1550341 ccttccgatt gttgaaggtt ctaccgttgt cacaaaatat ggttctgtaa aaacagacca 1550401 tgtattattt attgcagcag gagcgtttca tatggccaaa ccgtctgatt tgattcctga 1550461 gctgcagggg cgtttcccga ttcgtgtaga actgaacaaa ctcacggtag acgacttcgt 1550521 gagaattttg gttgagccgg ataatgcgct gctgaaacaa tatcaggcat tattgcagac 1550581 agaaggtata tctcttgaat tttctgacga agctattcat aagattgctg aagttgctta 1550641 tcatgtgaac caggacacag ataatatcgg tgcgagacgc cttcatacaa tacttgaacg 1550701 cctattagaa gatttgtcgt ttgaagctcc agatgtaacg atggagaaaa taacgattac 1550761 accacagtat gtcgaagaaa agctcggaac gatagccaaa aacaaagatt taagtcaatt 1550821 tatattgtga aaaatttaat atgaggaatg tttaggagga ttatttatca tggctttatt 1550881 acaaaaaaca agaattatta actccatgct gcaagctgcg gcagggaaac cggtaaactt 1550941 caaggaaatg gcggagacgc tgcgggatgt aattgattcc aatattttcg ttgtaagccg 1551001 cagagggaaa ctccttgggt attcaattaa ccagcaaatt gaaaatgatc gtatgaaaaa 1551061 aatgcttgag gatcgtcaat tccctgaaga atatacgaaa aatctgttta atgtccctga 1551121 aacatcttct aacttggata ttaatagtga atatactgct ttccctgttg agaacagaga 1551181 cctgtttcaa gctggtttaa caacaattgt gccgatcatc ggaggcgggg aaagattagg 1551241 aacacttatt ctttcgcgtt tacaagatca attcaatgac gatgacttaa ttctagctga 1551301 atacggcgca acagttgtcg gaatggaaat cctaagagaa aaagcagaag aaattgaaga 1551361 ggaagcaaga agcaaagctg tcgtacaaat ggctatcagc tcgctttctt acagtgagct 1551421 tgaagcaatt gagcacattt ttgaggagct tgacggaaat gaaggtcttc ttgttgcaag 1551481 taaaattgct gaccgtgtcg gcattacccg ttctgttatt gtgaacgcac tcagaaagct 1551541 ggagagcgcc ggtgttatcg agtctagatc attaggaatg aaaggtactt atatcaaggt 1551601 actaaacaac aaattcctaa ttgaattaga aaatctaaaa tctcattaat cacaaaaaga 1551661 accctttttg agggttcttt ttttatttca aataaaggaa atcaataagc tttatttcct 1551721 gggttgaaag tctttctatg taataatttt aataaatttt gcatttttct tcaaaaagtt 1551781 tcaaaaatgc cgaaaagaaa ggagaaaaaa cagaaattct gctattttca ggcttatatc 1551841 aaggcgagaa atgtagttct aacaatctag gactttatac ctagttgcaa aatagataat 1551901 tgtgaggaca tttttttaca cgaacttcat agactttatg cctgttattt cttacaataa 1551961 gcatatagtt ttacaattct cgacaaggat attgagggtg aaaaaaactg aaatggaggt 1552021 aagtggattt gagcttattt tctggaacga tacaaaatct tgaaaatgcc ttgagcagag 1552081 cggatattaa gcaaaaagtc ataactaata atatcgccaa tatagataca ccgaactata 1552141 aggcaaaaaa agtctctttc caaaatttat tagatcaaga atcctcgcgt cttgaagcga 1552201 taaaaacaga ctatcgtcat gttgattttt ctgatactga ttcgaattat tcaattgttg 1552261 cgagcggaga tacatcgtat cagcaaaacg gaaacaatgt tgatgttgac aaagagatga 1552321 cagaattggc gcaaaatcaa atcaactatc aagctttggt tgaaagaatg aacggtaaat 1552381 ttaattcgct gaagaccgta ttaacaggag gaaaatgatg acagcttttc atagcttaaa 1552441 tgtttcagca tcggctttaa cagctcagcg agtcagaatg gacgttgtat catctaactt 1552501 agcaaatatg gatacgacaa gagctaagca ggtgaatgga gagtgggtgc cttacagaag 1552561 aaaaatggtt tcccttcagt caaaaggtga atcgttctct tccattctca attctcaaat 1552621 gagcggaagc gggaatgctg gaaacggtgt gaaggtttca aaaattacgg aggatgattc 1552681 ggattttaat cttgtctatg atccgacaga ccctgatgca aacgctgaag gatatgtaca 1552741 aaagcctaat gttgatccat taaaggaaat ggttgatctt gtcagcagca ctagatcata 1552801 cgaggcgaat gtcacggcga tgaatgccac aaagggaatg ctgatgaagg cgttagaaat 1552861 cggaaagtag gcgaactgtt aaacaaggtg aaaaaacgat ttaattaagg tattaggggg 1552921 ataacaatgc aatccttgaa ttatgaagat caggtgcttt ggacgcgctg gaaagagtgg 1552981 aaagatccta aagccggtga cgacttaatg cgccgttaca tgccgcttgt cacatatcat 1553041 gtaggcagaa tttctgtcgg actgccgaaa tcagtgcata aagacgatct tatgagcctt 1553101 ggtatgcttg gtttatatga tgcccttgaa aaatttgacc ccagccggga cttaaaattt 1553161 gatacctacg cctcgtttag aattcgcggc gcaatcatag acgggcttcg taaagaagat 1553221 tggctgccca gaacctcgcg cgaaaaaaca aaaaaggttg aagcagcaat tgaaaagctt 1553281 gaacagcggt atcttcggaa tgtatcgccc gcggaaattg cagaggaact cggaatgacg 1553341 gtacaggatg tcgtgtcaac aatgaatgaa ggtttttttg caaatctgct gtcaattgat 1553401 gaaaagctcc atgatcaaga tgacggggaa aacattcaag tcatgatcag agatgacaaa 1553461 aatgttccgc ctgaagaaaa gattatgaag gatgaactga ttgcacagct tgcggaaaaa 1553521 attcacgaac tctctgaaaa agaacagctg gttgtcagtt tgttctacaa agaggagttg 1553581 acactgacag aaatcggaca agtattaaat ctttctacgt cccgcatatc tcagatccat 1553641 tcaaaggcat tatttaaatt aaagaatctg ctggaaaaag tgatacaata atgaatttca 1553701 tggttagcga gtgaaaaaca tgtcaacact attatggctt ttaagcttta tgctccacgg 1553761 cgttcttctg tacgctgtca ttatcctgta tacgaggctc gctgcagtga aagaaacaga 1553821 aaaacagcaa aaacagatac ttgaagagac ggaaaacacc ttggcggcat ttctgcttga 1553881 attaaaagaa gaaaatgaga aactgataga aaataaagct tcatctgcaa gtcaatcaga 1553941 tgaagaatcc caaaagtcag gccttcagac ctctgaaaca tatcaagagc gggatccagt 1554001 ccaagaggca gagaatcttc ctgaacatat tgaaggtctg attacagagg ttgaccgtcg 1554061 ggaagagctc gtaaacagtg aggtccaatc atttgaagac caggtcatag aattatatga 1554121 acagggatat tcggcaagtc aaattgccca gaaaatgaag agcggaaaga cagaaatcga 1554181 gctattttta aaatttcgct ccaaaggtgt aaaggattct tgattgtcgg ataaagctgt 1554241 gttatattat gtcttggtgt taaatacaca cgcttaacga tttatgcaga gggtgctgca 1554301 ggcggcagtt ctgtacaaaa atgacctaag cggaggaaaa aaaccattat attaggagga 1554361 aataacatgt cagtcatttc tatgaagcaa ttgcttgaag ctggtgttca cttcggtcac 1554421 caaacacgcc gttggaaccc aaaaatgaag cgttacattt tcacggagcg taacggaatc 1554481 tacatcattg accttcaaaa aacagtcaaa aaagtagagg aagcttacaa cttcactaaa 1554541 aatcttgctg ctgaaggcgg aaaaatcctt ttcgtcggaa caaaaaaaca agctcaagat 1554601 tctgttaaag aagaagctca acgctctggc atgtactatg tcaaccaacg ctggttgggc 1554661 ggtacattaa caaacttcga aacaatccaa aaacgtatta aacgtcttaa agacattgaa 1554721 aaaatgcaag aaaacggtac gtttgatgta cttcctaaaa aagaagtcgt tcaattgaaa 1554781 aaagaattag agcgtcttga aaaattccta ggcggaatta aagatatgaa ggatcttcct 1554841 gatgcattat tcatcatcga tcctcgcaaa gagcgcatcg ctgttgcgga agctcgcaaa 1554901 ttaaacatcc ctatcatcgg tatcgtagat actaactgtg atccagatga aatcgatgtt 1554961 gttatcccag cgaacgatga cgctatccgc gctgttaaac ttctaacttc taaaatggca 1555021 gatgcaatct tagaagcgaa gcaaggcgaa gaagaagcgg aagttgctga agaaactgca 1555081 ccagaaacag aaacaacaac tgcgtaacct attcaaaagg tgataagagg gactgccttt 1555141 tatcaccttt tttcaagaaa aatgtgtaat atacatactc ttgtttaaac atataaggag 1555201 gaatacaaat ggcaattact gcacagcaag taaaagaact gcgtgaaaaa actggcgcgg 1555261 gcatgatgga ttgtaaaaaa gcgttaactg aaactgacgg agatatggac aaagcaattg 1555321 accttttaag agaaaaagga attgcaaaag cagcgaaaaa agctgaccgt atcgcagcag 1555381 aaggttctac tcttattaaa actgacggca acaaaggcgt tatcctagaa gtaaactctg 1555441 aaactgattt cgttgcgaaa aacgaaggtt ttaaagagct tcttaacact ttagctgacc 1555501 accttcttgc aaacacgcca gctgatgttg aagaagcaat gggccaaaaa atggaaaatg 1555561 gctcaactgt tgaagagtac atcacaagcg cagttgctaa aatcggtgag aaaatcactc 1555621 ttcgccgctt tacagttctt acaaaagacg acagctctgc attcggtgcg taccttcaca 1555681 tgggcggccg catcggtgta ttaactgttc tcaacggtac aactgatgaa gaaactgcga 1555741 aagatatcgc aatgcacgtt gctgcagtta accctcgtta catttctcgt gatcaagtat 1555801 ctgaagaaga aacaaatcat gagcgtcaaa tcttaactca gcaagccctc caagaaggca 1555861 aacctgaaaa catcgtagcg aaaatggttg aaggccgtct gaacaaattc ttcgaagaaa 1555921 tttgtctatt agaccaagcg ttcgttaaaa acccagatga aaaagtgaaa caagttattg 1555981 cagcgaaaaa cgctactgtt caaacttttg tccgctatga agttggagaa ggcatcgaaa 1556041 aacgtcaaga aaactttgct gaagaagtaa tgaaccaagt gaaaaaataa tggtgaaaag 1556101 atttcgcggc taagtcgcgt cttttcaggc agtatagggg acacattttg tgttccctat 1556161 ttttaaaact atatttacaa accttttttt ctcttgcata atagaaaacg gcaatgttta 1556221 cacttggagg ttatcatgga aaaaccaaaa tacaaacgta tcgtattaaa gcttagcggg 1556281 gaagcattgg caggagaaca gggaaatgga attaacccga ctgtcattca atccattgca 1556341 aagcaagtga aggaaatcgc tgagcttgaa gtcgaagtgg ctgttgttgt aggcggcggc 1556401 aacttatggc gcggaaaaac aggaagtgac ctgggcatgg accgcgcgac tgctgactat 1556461 atgggaatgc tggcgacagt aatgaattcg cttgctcttc aagacagctt ggaaacactc 1556521 ggaatccagt ccagagtgca aacatccatt gaaatgagac aagttgctga accgtacata 1556581 agaagaaaag cgatacgcca cttagagaaa aaacgtgtcg ttattttcgc tgcgggcaca 1556641 ggaaacccat atttctcaac tgatacgaca gctgcactgc gggctgctga aattgaggca 1556701 gacgttattt taatggctaa aaataacgtt gacggtgtgt ataatgctga tcctagaaaa 1556761 gatgaatcag ctgttaagta tgaatcactt tcttatcttg acgttcttaa agacggcctg 1556821 gaagtcatgg attcaacagc ttcctcttta tgcatggaca atgacattcc gcttatcgtc 1556881 ttttctatta tggaagaagg aaatatcaaa cgtgccgtta tcggtgaatc aatcggaacg 1556941 atcgtgaggg ggaaataacg tgtcaaaaga agtattaact caaacaaaag aaaaaatgga 1557001 aaaagcaatt gctgcttatc agcgcgaatt ggctactgta cgcgcaggcc gtgcaaatcc 1557061 atcattatta gataaagtaa cggttgaata ttacggagcg cagacacctt taaatcagtt 1557121 gtcttctatt aacgtgcctg aagctcgtat gctcgttatc acgccatacg ataaaacagc 1557181 aatcggtgat atcgaaaaag cgattttaaa agctgattta ggtcttacac caacaagtga 1557241 cggcaatatg attcgaattg caattccggc actaacagaa gagagacgga aagaattagt 1557301 gaaagttgta aaaaaatatg ctgaagaagc aaaagtagct gttcgtaacg ttcgccgtga 1557361 tgctaacgat gatctcaaaa aacttgagaa aaacggagac attactgagg atgaactgcg 1557421 tgcttccact gaagacgttc aaaaactgac agatgaatat gtgtcaaaaa ttgacagtgt 1557481 cacaaaagac aaagaaaaag aaatcatgga agtttaatga aaaactatgt acaatagata 1557541 atagtgaaaa gaccctctca tgtttacagg gggttttttt gttaatactg ttgattacat 1557601 tgattatcag cagggaatgt aacctttttg ggtgacggag gaatctcatg ctcaacatac 1557661 tcaaaaattg gaagaatcag caaactgcgg cttccaactt agaacgttat acaaaagaag 1557721 acatacttaa gggagaaatt cccgaacaca tcgccattat catggatgga aatggccgtt 1557781 gggctaaaaa acgctctctt cccagaattg caggccacca tgaagggatg aaggtggtaa 1557841 aaaggaccac gaagctcgca aacgaattag gtgtcaaagt actgacattg tatgcatttt 1557901 caacagaaaa ctggaaaaga ccgaaaatgg aggtcgattt tttaatgaag cttccggaag 1557961 aatttttgaa tacgtatctt ccagagcttg ttgaggaaaa tgtacaggtt cggatcattg 1558021 gggatgaaac ggctttgccg gcgcacacat tacgtgcgat tgaaaaagct gtacaggaca 1558081 cggcgcaaaa cgacggaatg atccttaatt ttgctcttaa ctatggaggc cgtactgaaa 1558141 ttgtcagtgc tgcaaaatca ctcgcggaaa aagtgaagga aggctctttg aatattgaag 1558201 acattgatga atcgcttttt tctacttatt tgatgactga atctttgcag gatcctgaac 1558261 ttttaattcg aacgagcggc gagataaggc tgagtaattt tatgctatgg caggttgcct 1558321 acagtgaatt tgtctttact gacgtcttgt ggcctgactt taaagaagat cacttcttgc 1558381 aggcgttagg agagtttcag cagagaggcc ggaggtttgg cggaatttag aggatggtgg 1558441 acatgaaaca aagaattttg acaggtgttc tggcagcaat tgtattttta tttttggtta 1558501 ttgtcgggaa attgccgttc accatattaa tttatgctat gggcagtgtg gcgctttttg 1558561 aacttttacg gatgaaaaag ctgaagctgg tttcactgcc gggtttgatc ggtcttttat 1558621 tattgtggat gttcttatta ccaagccagt attcgttttt tgaagcggac gggatttcca 1558681 aaatggaaat cgctttattt gcggtactgc tattgctgac ttacacagtg ttggtcaaga 1558741 acacctttac ttttgatgaa gtcgggttta ttacgcttgc agcaatttac atcggaatgt 1558801 gttttcatta ttttatcgaa atcagaaatc ttgaccaata cggattaaca tacatttttt 1558861 atgcgtgtgt tgtcatttgg tccaccgatt ccggtgccta ttttgtcggt aaatcgcttg 1558921 ggaagcggaa actgtggcct gaaatcagtc cgaataaaac agtggaaggg tttgcaggcg 1558981 gaattgtcat cgcacttgta ttggcgacga tttttcagct tgttgcacaa cttccgatcc 1559041 cgtatatcta tctgctgttg atcacgctgt ttttgtctgt ttttggacaa ctgggagatt 1559101 tagtggaatc cgccttgaaa agacattacg atgtaaagga ttctgggaat attcttcccg 1559161 ggcatggcgg tatattagac cgttttgaca gtttcttgtt tgtcatgcct ttcttgtact 1559221 ttctgcttgc ccttttttca taaaaaagtc taatatgaat atgagactga tcatgcagca 1559281 ataagaatag gagtagtggc aactttgaaa aatatttgtc ttttaggagc aacaggatca 1559341 atcggcgaac agactcttga tgtactgcgt gcacatcaag accaatttca gctggtatct 1559401 atgtcgtttg gcagaaatat tgataaggcc gttccaatga ttgaggtctt tcagccgaag 1559461 tttgtctctg tcggtgatct ggatacatat cataaattaa aacaaatgtc tttttctttt 1559521 gaatgccaaa tcgggctggg agaagaagga ctgatagaag cagcagtgat ggaggaggtt 1559581 gacattgttg tcaacgcttt gcttggaagc gtcggtctta tcccgacatt aaaggcaatt 1559641 gaacagaaaa aaacaattgc gcttgcaaat aaggaaactc ttgtcactgc agggcatata 1559701 gtaaaagaac atgctaagaa atatgatgtt ccgctgctgc ctgttgacag tgagcattca 1559761 gccatttttc aagctcttca aggcgaacag gctaaaaaca ttgaacgcct catcattacg 1559821 gcatccggcg gaagttttcg ggacaagacg cgggaggagc tcgaatcagt aacggttgaa 1559881 gatgcattaa aacatccaaa ctggtcaatg ggtgcaaaaa ttacaattga ttcggctaca 1559941 atgatgaata agggattaga ggtgatcgag gcacactggc ttttcgatat accttatgaa 1560001 caaattgatg tggttttaca taaggagagc atcatccatt caatggttga gttccatgat 1560061 aaaagtgtga tcgcacagct cggaactccg gatatgagag tccccattca atatgcgctc 1560121 acttatcctg accgattgcc attaccagat gcgaaaaggc ttgaattatg ggaaatcggc 1560181 agccttcatt ttgagaaagc tgattttgac aggttccgat gcttacaatt tgcttttgaa 1560241 tcaggtaaaa taggaggaac aatgccgaca gtgctaaatg cggcaaacga agtagctgtc 1560301 gctgcctttt tagctggcaa gataccgttt ttggctattg aagactgtat cgaaaaggca 1560361 ctaacccgcc atcaattact gaaaaaaccg agcctggcgg acattcaaga agtggacaaa 1560421 gatacccggg gatacgtcaa ttcaatactc acataaggtg gtatgttcgt gaatacagtt 1560481 atagcgttta tcattatttt cggaacgctc gttttcttcc atgaactggg ccatttattg 1560541 ctagcccaaa gagcgggaat tctctgccgt gaatttgcga tcggcttcgg tccaaagatt 1560601 ttttctttca aaaaaaatga aacagtttat acgatcaggc tgcttccggt cggcggattt 1560661 gttcgtatgg ccggcgaaga tccggaaatg attgaggtga aacccggata cacggtcggg 1560721 cttctgttta ataaggaaga tcaagttgag aaagtcatca tcaatcaaaa ggaaaaatat 1560781 ccggatgctt tagtcattga agtggaaaca gcggatctag agcatgacat gaagatcacc 1560841 ggttatgaac aggggaaaga ggacgaactt tccagcttta ctgtcagcga aacatccttt 1560901 tttattgtag acggagaaga agtgcagatt gcgccgtata atcgccaatt tggttccaaa 1560961 cctgtatggc agcggattaa agcaattgct gcagggccga ttatgaactt tattttagct 1561021 tacgtcattt tagtgatgct tgggctgatt caaggcgtac cgtcaaatga acctatgctc 1561081 gggcagctga cagacaatgg acgggcggct gaagcagggc taaaagaagg ggattatatc 1561141 caaagcatta acggagagaa aatgaggtct tggactgaca ttgtctccgc tgtaaaagaa 1561201 aacccggaga aagaaatgga cgttgcagta aaaagagata acaaaacgct tcatatttcg 1561261 gtgactccgg aagctgttaa agatgagaac aaaaaaacaa tcggacgttt cggttcctat 1561321 gcgccgactg aaaaaggcgt actctcagcg gttgcttacg gcgcgacatc aacagttgat 1561381 gtcaccaaag ccattttaac caatctgagc aaattagtaa caggccaatt taaactcgat 1561441 atgctgtcag gtcctgtcgg catatatgac atgacagacc aagtggcgaa aacagggatc 1561501 gtgaacttat ttcagtttgc ggcgttttta agcattaacc ttgggattgt caacctgctt 1561561 ccgattccgg cacttgacgg aggaagactg ttgtttctat ttattgaagc gattcggggc 1561621 aaaccgatta acagggaaaa agaagcattt gttgtgttta tcggagtagc tttcttaatg 1561681 cttcttatgc tggttgtcac atggaacgat atccagcggc tgtttttgta aacgaaaagt 1561741 aaatcaatca gaggtgcgaa gaaatgagac aaagcttgac gcttattcct acgctccgtg 1561801 aagttccagc tgatgccgaa gcaaaaagtc atcagcttct tctgagagca ggatttatca 1561861 gacagaatac gagcggggta tacagctata tgcctcttgc gtataaggtg attcaaaaca 1561921 ttcagcagat tgttcgagag gaaatggaga aaattgatgc cgtagaaatg ctcatgcccg 1561981 cattgcagca ggcagagaca tggcaggaat caggcagatg gtatacgtat ggtcccgaac 1562041 tgatgagact aaaagaccgt catggccgtg aatttgcttt aggggcaacg catgaagagg 1562101 ttatcacttc gcttgttcgc gatgaggtta aatcttataa gcgtctccct ctgactcttt 1562161 atcaaattca gtctaagttc agagatgaaa aacgtcctcg cttcggtttg ttaagaggcc 1562221 gcgaatttat tatgaaggat gcgtactctt tccatgcatc tgcagagagc ctggatgaaa 1562281 cgtatcaaaa aatgtacgag gcctattcta atatttttgc ccgctgcggc attaatgtaa 1562341 gacctgttat cgctgattca ggcgcaatgg gaggaaagga tacgcacgaa tttatggcac 1562401 tttctgcgat cggagaggat acgattgcgt attctgatga atcacagtac gcggctaata 1562461 tcgagatggc tgaagttctt caccaggaag ttccttcaga tgaagagcct aaagctctag 1562521 agaaggttca tacgcctaac gtgaaaacaa tcgaagaact gactgcgttc ttacaggttt 1562581 cggctgaagc gtgcattaag tcagtattgt ttaaagctga tgaccgtttt gtcttagtgc 1562641 ttgtaagagg ggatcatgaa gttaacgata ttaaagtgaa aaacttgctt catgcagaag 1562701 ttgtagagct tgctacacat gaagaggtca ttcagcagct cggaacagag ccaggctttg 1562761 taggccctgt cggtattcat caggatgtgg aagtatatgc cgatcaagct gtgaaagcaa 1562821 tggttaatgc tgttgccggg gcaaatgaag gagatcatca ttataaaaat gtcaatgtga 1562881 atcgtgacgc gcaaattaaa gaatttgctg atcttcgttt tattaaagaa ggtgatcctt 1562941 caccagacgg caagggaacg atccgttttg ctgagggaat cgaagtcgga caagtcttta 1563001 agctcggaac acgctattca gaagcgatga atgcgacata tttagatgaa aacggacgcg 1563061 cgcagccaat gctgatgggc tgttacggaa tcggtgtgtc aagaacgctt tctgctattg 1563121 ctgaacagca tcacgacgaa aaaggcttaa tatggccaaa aagcgttgcg ccgtacgatc 1563181 ttcatattct tgctttgaac atgaaaaacg atgggcaaag agagcttgct gaaaagctgt 1563241 atgccgattt aaaagcggaa ggctatgaag tgctctatga tgaccgtgct gagcgtgccg 1563301 gcgtaaaatt cgctgattca gatttaatcg gccttccaat ccgcatcact gtcggaaaac 1563361 gagctgacga aggaatcgtc gaagtgaaaa ttcgtcaaac tggtgagtca actgagattt 1563421 cagtagacga attatctgcg tttatcagca agcagtaatc accataacga tttatcaaaa 1563481 aacatgttaa aatagaaata atagaaggta cctcattgcc tgaggtacct tcacttatga 1563541 tgtttttagg gagggatact gtcttaatgg aacagttatc agtaaacaga aggcagtttc 1563601 aaattcttct gcagcagatt aatatgacag atgatacctt catgacatac tttgaacatg 1563661 gcgagattaa aaagctgaca attcacaaag cttctaagtc ttggcatttt cattttcaat 1563721 ttaaatcttt gctgcctttt caaatatatg acacattaac aacgaggctg acgcaatcgt 1563781 ttgcccacat agcaaaagtg acatcttcaa ttgaagttca ggatgccgag gtcagtgaaa 1563841 gtatcgttca agactactgg tcacgctgca ttgaagaact gcagggcatt tcgccgccga 1563901 ttatcagtct tttaaaccag caaaaaccga agctgaaggg caataaactg attgtcaaaa 1563961 ccaaaacaga tacagaagcg gctgcgctaa agaacaaata cagttccatg attcaagcag 1564021 aataccgtca atttggcttt ccggatcttc agcttgatgc tgaaatattt gtatccgagc 1564081 aagaagttca aaagtttcgg gagcaaaagc ttgcggaaga ccaagagcgg gctatgcagg 1564141 ccttgattga aatggagaag aaagataaag aaagtgatga agaccaagca ccatctggtc 1564201 ctcttgttat cggttatcaa attaaagata acgaggaaat ccgaacactt gacagcatca 1564261 tggacgaaga acggagaatt acggtccaag gttatgtgtt tgatgtggag acgcgcgagc 1564321 tgaagagcgg gcgcacgctg tgtatcttca aaattacaga ctatacaaat agtattttga 1564381 tcaaaatgtt tgcacgtgaa aaagaagatg cggcgctgat gaagtctctg aaaaaaggaa 1564441 tgtgggtaaa agcacgcgga agcattcaaa atgatacatt tgtcagagac cttgtcatga 1564501 tcgcaaatga cgtaaacgaa ataaaagcaa aaacccgtga agattcagca cctgaaggag 1564561 aaaaaagagt ggaattgcat cttcattccc caatgagcca aatggatgct gttacgggta 1564621 tcggaaagct tgtcgaacag gcgaaaaaat gggggcatga ggccatcgct ttgaccgacc 1564681 atgctgtcgt tcaatccttc cctgatgcgt attctgcggc caaaaagcat ggaattaaaa 1564741 tgatttacgg gatggaagcg aatctcgtgg atgatggcgt gccaattgct tataatgccg 1564801 cacatcgtct gctcgaagaa gaaacatatg ttgtttttga cgttgagacg acaggattgt 1564861 ctgctgtata cgataccatt attgagctgg ctgcagtaaa agtaaaaggc ggagaaatta 1564921 ttgataaatt tgaggcgttt gcgaacccgc atcgtccgct ttccgccaca atcatagagc 1564981 tgacagggat cacagatgat atgctacaag acgctccgga tgtcgtagat gtaataagag 1565041 atttcagaga atggattggc gatgatattc ttgtcgctca taatgcaagc tttgatatgg 1565101 gattcttaaa tgtagcctat aaaaaacttc ttgaagtcga aaaagctaaa aacccagtca 1565161 ttgatacgct tgaacttgga cgttttctct atccggaatt taagaaccac cggttgaaca 1565221 cactttgtaa aaagtttgat atcgagctca cacagcatca ccgtgcgatc tatgatactg 1565281 aggcaaccgc ttatttgctt ctgaaaatgc tgaaagacgc agctgaaaaa ggtattcagt 1565341 accatgatga gttgaatgaa aatatgggtc agtccaatgc ttatcaaaga tcaagaccgt 1565401 atcatgcaac attacttgcc gtgaacagca cgggacttaa aaatttattt aagcttgtgt 1565461 cactttctca tattcattat ttttacagag tgccgcgtat tccgagatct cagcttgaga 1565521 aatacaggga agggcttctg atcggttctg cttgtgacag gggagaggtt tttgagggaa 1565581 tgatgcaaaa atcgcctgaa gaggtggaag atatcgcgtc attctatgat taccttgagg 1565641 ttcagccgcc tgaagtgtat cgtcacttgc tggagcttga actggtccgt gatgaaaaag 1565701 cgctgaaaga aattattgcg aatatcacga agctggggga aaagcttaat aaaccggttg 1565761 ttgctacggg aaatgttcat tacttgaatg atgaggataa aatctacaga aagattttaa 1565821 tatcctcaca aggcggggca aatccgctga ataggcatga actgccgaaa gtgcatttca 1565881 gaacgacaga cgaaatgctt gaagcttttt ctttcttagg tgaagaaaaa gcgaaggaga 1565941 tcgtagtcac caatacccaa aaggttgctt ctttagttga tgacatcaag ccgattaaag 1566001 atgatttata tacgccgaaa atcgaaggcg ctgatgaaga gatcagagaa atgagctatc 1566061 agcgtgcaag aagcatttac ggggaagagc tgcctgaaat tgtcgaagcg cggattgaaa 1566121 aagagttaaa gagtattatt ggccacggat ttgctgttat ttacttgatc tctcacaaac 1566181 ttgtaaaacg ttcactagat gacgggtatc tcgttggttc ccgtggttcc gtaggatctt 1566241 cattagttgc gacacttact gagattactg aggtaaaccc gctgccgccg cactatgttt 1566301 gtcctgagtg ccagcattct gagttcttta atgacggttc tgtcggttct ggttttgacc 1566361 tgcctgacaa gacatgccct cattgcggaa cgcctttgaa aaaagacggc catgatattc 1566421 catttgaaac gttcttagga tttaaagggg acaaagtacc tgatatcgat ttgaacttct 1566481 caggggaata tcagccgcaa gcacacaatt acacaaaagt attgttcgga gaagacaatg 1566541 tatatcgtgc gggaacaata ggcacggtgg cagaaaaaac agcctacggt tatgtaaaag 1566601 gctatgccgg agacaacaat cttcatatgc gcggtgccga aatagatcgg ctcgtacagg 1566661 gatgcacagg tgtaaaacgt acaactggac agcaccctgg cggtattatc gtagttccgg 1566721 attatatgga tatttatgat ttttcaccga tccagttccc ggcagatgcc acaggttcag 1566781 agtggaaaac gactcatttt gatttccact ccatccatga caacctgtta aaacttgata 1566841 ttctcggaca cgatgacccg actgttattc ggatgcttca agacttaagc ggaatagatc 1566901 cgaaaacaat tccgacggat gatcctgaag tgatgaagat cttccaggga accgaatcac 1566961 tcggtgtgac tgaagaacag attggctgta aaacgggcac tcttggaatt cctgaattcg 1567021 gaacccgatt tgtccggcag atgcttgaag atacaaagcc gaccactttt tctgagctcg 1567081 ttcagatttc aggcttgtct cacggaactg atgtatggct tggcaatgca caggagctca 1567141 tccacaataa tatttgtgag ctgagtgagg ttatcggctg ccgtgatgac attatggttt 1567201 atttaatcta tcaaggcctt gagccgtccc ttgcctttaa aatcatggaa ttcgtgcgta 1567261 aaggaaaagg attaacgcct gaatgggaag aagaaatgaa aaataacaat gtcccagact 1567321 ggtatattga ttcctgtaaa aagattaaat acatgttccc gaaagcccac gccgcggcat 1567381 atgtcttaat ggcagtccgc attgcttact ttaaagtgca tcatgctctt ttgtattatg 1567441 cggcttattt taccgttcgt gcagatgact ttgatattga tacaatgatc aagggctcta 1567501 cagcaatcag agcggtaatg gaggatataa acgctaaagg acttgatgct tcaccgaagg 1567561 aaaagaacct tctgactgtt ttagaattag cgcttgagat gtgtgagaga ggctattcat 1567621 tccaaaaagt cgatttatat cgctccagcg ccacagagtt tattattgac ggcaacagtc 1567681 ttattccgcc gtttaactct attccagggt tagggacgaa cgctgctttg aacattgtaa 1567741 aagctcgcga agaaggcgaa ttcctctcaa aagaagattt gcaaaagaga gggaaagtat 1567801 caaaaacgat tttagagtac ttagatcgcc atggctgtct ggagtcactg cctgatcaaa 1567861 accaattgtc actgttctaa tatggaaagc agaatttctc agaaattctg cttctatgca 1567921 tacataagcg caaaaagtgc catcgtaata ttagagtttc tgtcacttgc ttaggtatga 1567981 aggtaagcgt atatccattt gcaataaaaa tatggttatg gtatagtttt attggaaatg 1568041 ctaacgatta ccgaggcaaa gagtggggaa acccgctctt ttgtattgaa caggagaatt 1568101 ttgtctcgac atgttcatcg tttacttttt agcccctgct cttttgaagc agggttttta 1568161 tgcagagtga cgagacgaat atgagatcga cagcacaagg aggaagaaca tgagcaaaaa 1568221 agtgactgac accgttcaag aaatggctca gccaatcgta gacagccttc agctggaact 1568281 cgttgacatt gaatttgtca aagagggcca aagctggttc cttcgcgtgt ttattgattc 1568341 cgatgacggt gtggatattg aggaatgtgc caaagtaagc gaagctttaa gcgaaaagct 1568401 tgatgaggca gacccaatca gccaaaatta ctttcttgaa gtctcatctc caggagctga 1568461 gcgtccgcta aagaaaaaag ccgatttcga aaaatcacta ggaaaaaacg tatacattaa 1568521 gacgtatgag cctattgacg gcgtaaaagt gtttgaaggt gaactggctg aatttgatgg 1568581 acaaacagtg acagttgaga tcacgatcaa aacaagaaag aaacggatca atattccgta 1568641 tgaaaagata gctaatgcaa gattagctgt tacattctaa tgaatacaaa tgttttaagg 1568701 ggggagaccg ttaaatgagc agtgaattat tagatgctct cacgattctt gaaaaagaaa 1568761 aaggcatcag taaagaaatt atcatcgaag caatcgaagc tgcgttaatt tctgcttata 1568821 agcggaattt taatcaagcg caaaatgtac gggtggatct aaaccgtgaa actggctcca 1568881 tccgtgtatt tgcaagaaaa gatgtcgttg acgaagtata cgaccagaga ttagaaatct 1568941 caattgaaga ggcacagggc atccatccgg aatatatggt cggcgatgtc gtcgaaatcg 1569001 aagttacacc taaggatttc gggcgcatag ctgctcaaac agcgaagcag gtcgtcacac 1569061 agcgtgtgcg cgaagctgag cgcggtgtga tttattctga atttatcgac cgtgaagaag 1569121 acatcatgac agggatcgtc cagcgtctgg acaataaatt tatctacgtg tctttaggca 1569181 aaatagaagc cttgctgccg gttaatgagc aaatgccgaa tgaaagctac aagccccatg 1569241 accgcattaa ggtatatatc acaaaagtag aaaaaacaac gaagggtccg cagatttatg 1569301 tgtcaagaac acatccaggc ctgttaaagc gtttgtttga aattgaagtg cctgaaattt 1569361 atgatggaac tgtcgagcta aaatctgttg ccagagaagc cggcgaccgt tcgaaaattt 1569421 ctgttcgcac agatgatcct gacgttgatc ctgtcggttc atgcgtaggg cctaaaggcc 1569481 agcgtgtgca agcaatcgtc aatgaattaa aaggtgaaaa aattgacatt gtcaactggt 1569541 ccagtgatcc tgtagaattt gtcgcgaatg cgctcagccc ttccaaagtg cttgatgtca 1569601 ttgttaatga agaagaaaaa gcgacaactg ttattgttcc tgattaccag ctgtctctgg 1569661 caattggaaa aagaggacaa aacgcacgct tagctgctaa actgacaggc tggaagattg 1569721 atattaagag cgaaacggac gcaagagaac ttggaatcta tccgagagaa cttgaagaag 1569781 atgatgagcc gctctttacg gagcctgaaa ctgctgaatc ggatgaataa gaggtgactt 1569841 taggtgaata aacacaaaaa gatcccatta cgcaaatgtg tagtgactgg tgaaatgaag 1569901 cctaaaaagg aactgatccg agttgtacgg tcgaaagaag gcgaaatctc agtagacccg 1569961 accggaaaaa agaatgggcg gggtgcttat ttaacgctgg ataaagagtg catcttagca 1570021 gcaaaaaaga aaaacacttt gcaaaatcaa tttcaatcac aaatcgatga ccagattttc 1570081 gatgaattgc tggaactggc ggaaaaggtg aaaaaataaa atgtctggaa tggaatggtt 1570141 tcccttgctg ggtctggcca atcgagctcg taaggtcgtg tcaggcgaag acttggtaat 1570201 aaaagaaatc aggaatgcgc gtgcaaagct tgtcctgctt acagaggatg catcatctaa 1570261 cacagcaaaa aaagtaactg acaagtgcaa ttattataaa gtcccttata aaaaagtcga 1570321 gagtcgcgcg gttcttggac gctctatcgg taaagaagcc cgtgtcgttg tcgccgtcac 1570381 tgaccaaggt tttgcgaata agctgatcag cttgctcgat taatattttt gggggtgaac 1570441 gaatggctaa aatgagagta tacgaatatg caaaagcgtt aaatgtttca agtaaggaaa 1570501 ttttgaccgc actgaagaac atggatttag aagtgaataa tcacatggcc atgcttgaag 1570561 aaaaggccat taaaaagcta gatgccaaat ataaaaaagg cggcgcagct gctaaatctc 1570621 aaaagccagc agaaacgaac aaaaacaaac agccacaagg ggttaatcag caatcagctg 1570681 gaaatcaacc aaataaaatt cgagacggaa agaagaatga cgtgcagaat aatcaattta 1570741 acaaaaacaa gaagaataac aacaacaaaa aaaataaacg caacaacaac aataataaaa 1570801 accaacatca gcaaaagcct gtaaagccga aaaaagagct tcctgagaaa attacattct 1570861 ctggcacttt aacagttggc gcacttgctg aagagcttgg caaagagcct tcagaactca 1570921 ttaaaaagct gatgcttctt ggcgtaatgg caaccattaa ccaagagctt gataaagaca 1570981 caatcgaact cattgcatca gaatatggtg ttgaaacaga agaggtcatt gtgcttgaag 1571041 aaacagagct ggaaaaatac gaagagcctg ataatgaaga ggatcttgaa attcgtcctc 1571101 ctgtcgtgac aatcatgggc cacgttgacc atgggaaaac aacgcttctt gacagcatcc 1571161 gtaaaacaaa ggttgttgaa ggggaagcag gcggaatcac tcagcatatc ggcgcttatc 1571221 aaattgaaga gaacggcaag aaaatcacgt tcttggatac accgggccac gccgcattta 1571281 caacaatgcg cgcacgcggt gcagaagtaa ctgatattac gattcttgtc gtagctgccg 1571341 atgacggtgt catgccgcaa acagttgaag cgattaacca tgcaaaagca gcagaggttc 1571401 caatcatcgt tgctgtgaat aaaatagata aagaatccgc aaaccctgac cgtgtaatgc 1571461 aagaactgac ggaatacgga cttgtccctg aagcttgggg cggagaaacc atttttgtgc 1571521 cgctttccgc tttaactgga aaaggcattg atgagctcgt tgaaatgatt ttgcttgtca 1571581 gtgaggtaga ggaactgaaa gcgaatccga atcgtcaggc aaaaggaacg gttattgaag 1571641 ctgaactcga taaaggcaga gggtcagtcg cgacgttgct cgtacagact ggaacactgc 1571701 atgtcggtga tccgatcgta gtcggcaata catttggccg tgtccgtgca atggtcaacg 1571761 acattggccg ccgtgtgaaa actgccggcc cgtcaactcc ggttgaaatt accggtttga 1571821 atgatgtccc tcaagcggga gaccaattcc ttgtctttaa ggatgaaaaa acagctcgtt 1571881 ctgtcggtga agcccgtgct tcgaaacagc ttgaagagca gcgcagcgat aaagcgaagc 1571941 tcagtcttga tgatttattt gagcaaatta agcaaggtga tgtaaaagac atcaacctca 1572001 tcgtaaaagc tgacgttcaa ggatctgctg aagctttaac ggctgcactt caaaaaattg 1572061 aagtagaagg cgttaaagtg aaaatcatcc atacaggcgt tggtgcgatt actgaatcag 1572121 acattatctt ggcatctgct tccaatgcaa ttgttatcgg gtttaatgtg agaccggacg 1572181 gaaatgctaa gagtacggct gaagctgaaa atgtagatat tcgacttcac cgtatcattt 1572241 acaaagtaat cgacgagatt gaagctgcca tgaaaggtat gcttgatcct gaatatgaag 1572301 aaaaagtaat tggtcaagta gaagtacgcc aaacattcaa agtatctaaa atcggtacaa 1572361 ttgccggcgg atatgttact gaaggaacca ttacgcgcga cagcggcctc cgtttaattc 1572421 gtgacggcgt cgtcatcttt gaaggcgaag tagatgttct gaaacgcttt aaagacgatg 1572481 tgaaagaagt ttcacaaggc tatgaatgtg gtattacaat taagaaatac aatgacattc 1572541 gtgaaggtga catccttgaa gcgtttgtca tgcaagaaat tgaaagaacg tgatcggatt 1572601 tgcggagtgt gaatgcatca tttatgatgc aggatcgcta aaagaaaagc gtgccgttct 1572661 gaagcggatt ttaaccaggg ttcaaaacaa gttcaatgtt tcgatttcgg agattggcta 1572721 tcaggacacc tggcaaagaa ccagcttcgg aatcgccgct gtttcttcct ctcgcgttca 1572781 aacagaaaaa gaactgcagc gcgtcctagc gtttatcgat tcttttcctg aaattgaacg 1572841 gacgatcact aggacagagt ggttttaact tagaggtgat tgaattgagt atgagagcaa 1572901 accgtgtcgg cgagcaaatg aaaaaagaac tcggtgatat tatcagccgc aagctgaaag 1572961 acccgagaat tggttttctg acagtaacgg atgtacgtgt atcaggtgat ttgcaaattg 1573021 caaaggtgta tatctcggtt ctcggtgacg agaaaaaacg ggaagaagcg ctgaaagggc 1573081 tggcaaaagc gaaaggattt atccgatccg aaatcggcag ccgcatcaga cttcgaaaaa 1573141 cgcctgaaat tgaatttgag ttcgatgaat caatcgatta cgggaatcgg atcgaaacac 1573201 tgattcacga attacattca gagaaaccat ctgaataaaa aaagagagga taggcgtata 1573261 tcgtctgtcc tctttcttcg tttataagaa aaaaactcaa aagaaggagt gaaaggcaaa 1573321 tggttaacgg agttctcctt ttacataaac ctgttggcat gacatcgcac gactgtgtca 1573381 tgaagatccg aaagctgtta aaaacaaaaa aagtaggaca tacaggaacg ctcgatccgg 1573441 aagtatcagg cgtgcttccg atttgtgtag gaagagcgac aaaaatagtc gaatacttaa 1573501 ctgaaaaatc taaaacgtat gatgcagaaa taacattggg cttttcaacc acaacagagg 1573561 atcaaaccgg agaaacggtg gaaacaaagc ctgtcaatca cgacattgat aaagcggatg 1573621 tagaaaaggt tttaaacagt ttaaagggga aacaagaaca aattccgccc atgtattccg 1573681 ctgtaaaagt aaacggcaaa aaattatacg aatacgcaag agcagggatt gaagtagaac 1573741 gtccgaaacg tatgataacc attgaagaca ttgccctgac aacagagatt aaacatcatg 1573801 gagaaaccgc aagcttccgg tttacagtga cttgctccaa agggacctat gtaaggacgc 1573861 tggcggtcat gatcggagaa aagctcggat atccggccca tatgtctcat ttaatccgta 1573921 cggcatccgg agatttttct ctcgacgaat gctttacttt tgatgaactc gaagcacagg 1573981 cccaatccgg aaccgtggaa gagcatacag ttcctattga acgtgcgctc aatcatttgc 1574041 cgaaatggat cataagtgat acattagcta agaaagtaga aaatggggct ttgcttgaga 1574101 cgcccgagca gttttctgaa atgacaagtg gagaccgtat tgccgtcttt actgaatccg 1574161 gaacctgctt ggcgatctat ttccctcatc ctgcaaaaaa agggctgtta aagccggcaa 1574221 aagtattgat gcaaaaaagc gaacaataga aaaaaggtga ccgttctgtg aagacgatac 1574281 atattacaca tcctcatcat ttaataaaag aggagcaggc aaaatcagtg atggcgttag 1574341 gttattttga cggcgttcat ctcgggcatc aaaaggtaat cggcacagcg aagcaaatag 1574401 ccgaagaaaa aggtctgaca ttagctgtga tgacctttca tccccatcct tctcacgtgt 1574461 tgggcagaga taaggaacca aaggatctga ttacgcctct tgaagacaaa ataaaccaaa 1574521 ttgaacaatt aggcacagaa gttctgtatg tcgttaaatt taatgaagtg tttgcttctc 1574581 tttctcctaa gcagtttata gaccagtata ttatcggcct taatgtgcag cacgcagtgg 1574641 caggctttga ctttacgtac ggcaaatacg gcaagggaac aatgaagacc atgccggatg 1574701 atttagacgg aaaagctggg tgcacaatgg tagaaaaatt aacggagcag gataaaaaaa 1574761 tcagttcttc gtatatccgt accgcgcttc aaaacggaga tgttgaattg gcgaatgtct 1574821 tgcttggaca accttatttt attaaaggaa ttgtcattca tggtgataaa agagggcgga 1574881 ccatcgggtt tccgacagcg aatgtcggtt taaataacag ctatatcgtt ccgcccacag 1574941 gtgtatatgc cgtaaaagcg gaagtgaacg gcgaagttta caatggcgtt tgcaatattg 1575001 gctataagcc aacgttttat gaaaagcgcc ctgaacagcc ttccatcgag gtcaatctgt 1575061 ttgatttcaa tcaagaggta tatggagccg ctataaaaat cgaatggtac aaacggattc 1575121 ggagcgagcg gaaattcaat ggcatcaaag aattaactga gcaaattgag aaagataagc 1575181 aggaagccat ccgttatttc agcaatttgc ggaaataact tgcaacgcac gcaaatttta 1575241 ttctaaaata tttgcatata ggcacgattt ttagtatgat agttttcgta gtcttaaaac 1575301 cattgcttgg caatccgaag tcaccgacgg ttgctaggta actggggcta aatatgattt 1575361 ggaggtgaaa caggatggca attactcaag agcgtaaaaa ccaactcatc aatgagttca 1575421 aaacacacga atctgatact ggatctccag aagttcagat cgctatccta actgactcaa 1575481 ttaacaactt gaacgagcat ttacgtactc acaagaaaga ccaccactca cgtcgcggtc 1575541 ttcttaaaat ggtaggtaag cgtcgtaatc ttcttacgta tctgcgtaat aaagacgtaa 1575601 ctcgttaccg tgagttaatt aacaaactag gcttacgtcg ataatcgtaa aaagcgggag 1575661 gattcccgct tttttatcgt attaaagcga aatttcttat aacaaatcat tgaaatcctt 1575721 ttacatacta ctttgacatt gatatgttca attcatttcg ttcataatag gagtaattga 1575781 ttatttcaca caacgaagag aggagttcgt aattgtatgg gacaagaaaa acatgtcttt 1575841 accatagatt gggccggaag aacgcttacc gttgaaaccg gccagcttgc caaacaggca 1575901 aatggtgctg tgatgatccg ctacggtgat acagcagtac ttagtacagc aaccgcttca 1575961 aaagaaccta aaccgcttga tttcttccct cttactgtaa actatgaaga aagattatat 1576021 gcggtaggga aaattccggg cggatttatt aaaagagaag gacgtccaag tgaaaaagcg 1576081 gttcttgcca gccgtttaat tgaccgtccg atccgtcctt tgtttgccga tggattccgt 1576141 aatgaagttc aagtcatcag cattgtcatg agtgttgacc aaaactgctc ttcagaaatg 1576201 gctgccatgt tcggttcatc tcttgcactt tctgtatcgg atattccgtt tgaaggaccg 1576261 attgcagggg ttactgtcgg acgcattgat gatcaattta tcattaaccc gacagtcgat 1576321 cagcttgaaa aaagcgatat caatcttgtc gttgccggca cgaaagatgc gattaacatg 1576381 gtagaagcgg gagcggacga agttcctgag gaaatcatgc ttgaggccat tatgttcggc 1576441 catgaagaga ttaaacgcct gattgcattc caagaagaaa ttgttgcagc agtcggcaaa 1576501 gagaaatctg aaattaagct ctttgaaatt gatgaagagc ttaatgaaaa agtaaaagct 1576561 ttggcagaag aggatctgct gaaagccatc caagttcatg aaaagcatgc ccgtgaagat 1576621 gccattaacg aagtgaagaa cgcagttgtg gcaaaattcg aggatgaaga acatgatgaa 1576681 gacacaatca agcaagtgaa gcagatttta tccaagcttg tgaaaaatga agttcgccgc 1576741 ctgattactg aagagaaagt aagaccggac ggccgcggtg tcgatcaaat ccgtccgctc 1576801 tcttcagagg ttggcctctt gccaagaacg cacggttcag gtctatttac aaggggacaa 1576861 actcaggccc tcagcgtatg tacgctaggt gctctgggag atgtgcaaat ccttgacggc 1576921 ttaggtgtcg aagagtcgaa acggtttatg catcattaca acttcccgca attcagcgtt 1576981 ggggaaacag gaccgatgcg cggaccggga cgtcgtgaaa tcggacacgg agcactgggt 1577041 gagcgtgcgc ttgagccagt tattccgtct gaaaaagact tcccttatac tgtccgtctt 1577101 gtttcagaag tgcttgaatc aaacggttct acatctcaag caagcatttg cgcaagcaca 1577161 cttgcaatga tggatgccgg tgtaccgatt aaagcgccag ttgctggtat tgcgatgggt 1577221 cttgtcaaat caggcgaaca ttacactgtc ttgactgaca tccaaggcat ggaagacgcg 1577281 ctcggagata tggactttaa agtagcggga actgaaaaag gcgtaacggc cctgcaaatg 1577341 gacattaaaa ttgaaggcct ttccagagag attcttgaag aagcgcttca gcaggcgaaa 1577401 aagggcagaa tggaaatcct caacagcatg cttgcaacat taagcgaatc aagaaaagag 1577461 ctttctcgat atgcgcctaa gatcttaaca atgaccatta atcctgataa aatccgcgat 1577521 gtcatcggac caagcgggaa acaaatcaat aagatcatcg aagaaaccgg tgttaaaatt 1577581 gatattgagc aggacggcac aatctttatt tcctctacag atgaaagcgg caaccaaaaa 1577641 gcgaaaaaaa tcatcgaaga ccttgtgaga gaggttgaag tcggccaact ttacctaggt 1577701 aaagtgaaac ggattgaaaa attcggggct ttcgttgaaa ttttcagcgg aaaagacggt 1577761 ttggtgcaca tttcagagct tgcgcttgaa cgcgtaggga aagttgaaga tgttgtgaaa 1577821 atcggagacg agattcttgt caaagtcact gaaattgata aacaaggacg agtgaattta 1577881 tcccgcaaag cggtgctccg tgaagagaaa gaaaaagaag aacaacaatc ttaaatgaaa 1577941 acataaaagg agcctgggag acccggcttc tttattttga agcttttcaa aagcaggcgg 1578001 gttctacctt gtccttctcc ttcataatgt gaggtgaggg ggggacagaa catgtacaaa 1578061 aaatttgtac cgtttgccgt ttttttattt cttttttttg tctcatttga gatgatggaa 1578121 aatccgcatg cacttgatta tataggggca atgaaaaaag atacggtgac tgtcacggcg 1578181 tcaaaagacc cgttatatga agaattgctt caaaaagcgc cggagtacga agttaagccc 1578241 cagaatgcaa gaattgataa agtgtggaaa agcattccag gctacaatgg attaaaggtc 1578301 aatattgaac aatcatataa aaaaatgaaa cagcatggta agtttcggga aaaagatttg 1578361 gtgtacagtc aagtaaaacc aagtgttcat cttgagtcac ttcagcctga gcctatttat 1578421 aaaggaaatc ctgacaaacc gatggtggct tttttaatca atgtggcatg gggaaatgag 1578481 tatttggaaa aaatgcttcc tattctgcaa aagcaccagg ttaaagctac gttcttttta 1578541 gaaggcaatt gggtgagaaa caatgtacag ctcgctaaga agattgcaaa agacggacat 1578601 gaaatcggaa atcattcata caatcatccg gatatgagca aactgactac aggaagaatt 1578661 tccgagcagc tcgacaagac taatgaacaa atagaacaaa cgatcggcgt taagccaaag 1578721 tggttcgctc cgccaagcgg aagtttcaga aaagcggtta tcgacattgc agcagagaaa 1578781 cagatgggaa cagtcatgtg gacagttgat acaatcgatt ggcaaaagcc ggctccgtct 1578841 gtacttcaga cgagagtgtt aagcaagata cataatggtg ccatgatttt aatgcatccg 1578901 actgacccta cggcggaaag tcttgaagcg ctgattacac agataaaaga caaaggatat 1578961 gcgcttggaa cagtcactga actaatggat gaaacaagac tattgaagta acagatgaag 1579021 gcagcttgtc tttgaatagg aggaacaaat ttgattaaac gatatacgtg tcaaaatggt 1579081 gtaagaattg tgctggaaaa taacccgaca gtccgttctg ttgcgatcgg cgtatggatc 1579141 ggcacaggtt cgagacatga aacgccggag ataaacggaa tttctcactt tttagagcac 1579201 atgttcttta aagggacgag cacaaaatct gcacgcgaga tagcagaatc ttttgatcgt 1579261 attggcggcc aggtcaatgc gtttacttca aaggaatata cctgctacta tgcaaaggtg 1579321 cttgacgagc atgcgaatta cgcgctggac gtattagcag atatgttctt tcattcaacg 1579381 tttgatgaaa acgagctgaa aaaagagaaa aatgtagtat atgaagaaat taaaatgtat 1579441 gaagatgcgc cggacgacat tgtacatgat ttattgagca aagccactta cggcaatcat 1579501 tctttaggct acccaatttt aggaacggaa gaaacgcttg cttcctttaa cggtgactct 1579561 ctcagacaat acatgcatga ttattatacg ccggaccgag tggtgatttc ggtagcgggc 1579621 aatatatctg acagttttat caaagatgta gaaaaatggt tcgggtcata cgaggcgaaa 1579681 ggcaaagcga caggccttga gaagcctgag ttccacacgg aaaaactgac gagaaaaaaa 1579741 gaaacagagc aggctcattt gtgccttgga tttaaaggct tagaggttgg ccatgaacgt 1579801 atttatgatt taatcgtcct caacaatgtg ctcggaggca gcatgagcag ccggctgttc 1579861 caagatgtgc gtgaagataa aggacttgct tattctgttt acagctatca cagctcatat 1579921 gaggacagcg gaatgctaac gatttacggc ggaacgggtg caaatcagct tcagcagctg 1579981 tcggaaacaa ttcaagaaac cctggccaca ttaaaacgtg acggcattac ctcgaaagaa 1580041 ctggaaaaca gcaaagagca aatgaaggga agcttaatgc tgagcttaga aagcacaaac 1580101 agcaaaatga gccgaaacgg aaaaaatgaa ctgctgctcg gcaaacataa aacattagat 1580161 gaaattatca atgaattaaa cgccgtgaac ttagagcgtg ttaatggcct tgccagacaa 1580221 ttgtttaccg aagactatgc attagcactt atcagccctt ccggcaatat gccgtcttaa 1580281 aaaggaaagc ctgccccata atggagcagg cattttttaa tccctttcat catacatagt 1580341 acaagggggt gacagacatg cggctcagtg aattatcggg aaaggaaatt gtagacatca 1580401 aaagagctga acggctcgga gtgctcggcc agaccgattt ggaaatcaat gaacaggatg 1580461 gacagattac agcactcctc attcccacag ttaagtggtt tggtttgaga aagcaaggtc 1580521 atgacattcg tgtcccatgg caccatattc aaaagatcgg ttcagatatg attatattag 1580581 atgtacctga ggaaatgcct cctcgacaag agtaaatagc ccaattgact gtgaagcggg 1580641 ctctaaagaa aacatctgaa acatcggctg ccggagccga tgttttttta tatggaaaaa 1580701 gcgcatcttt tatattcacc ggtatttcct tttgatcata agatgaaggg gagcttaaca 1580761 actagagatc cagtatatac aaagaaggtg aacgtttaga atgttaaccg gattgaaaat 1580821 tgcagttatc ggcggtgacg caagacagct cgaaattata agaaagctca ctgaacagca 1580881 ggctgacatc tatcttgtcg gttttgacca attggatcac ggttttaccg gggcagtaaa 1580941 atgcaatatt gatgaaattc cttttcagca aatagacagc atcattcttc cagtatccgc 1581001 gacaacagga gaaggtgtcg tatcgactgt attttcgaat gaagaagttg tgttaaaaca 1581061 ggaccatctt gacagaacgc ctgcacattg tgtcattttc tcaggaattt ctaacgccta 1581121 tttagaaaac attgcagctc aggcaaaaag aaaacttgtt aagctgtttg agcgggatga 1581181 cattgcgata tacaactcta ttccgacagt agaaggaacg atcatgctgg ctattcagca 1581241 cacggattat acgatacacg gatcacaggt ggccgttctc ggtctggggc gcaccgggat 1581301 gacgattgcc cgtacatttg ccgcgctcgg ggcgaatgta aaagtggggg caagaagttc 1581361 agcgcatctg gcacgtatca ctgaaatggg gctcgttcct tttcataccg atgagctgaa 1581421 agagcatgta aaagatatag atatttgcat taataccata ccgagtatga ttttaaatca 1581481 aacggtactt tctagcatga caccaaaaac cttaatattg gatctggcct cacgtcccgg 1581541 gggaacggat tttaaatatg ccgagaaaca agggattaaa gcacttcttg ctcccgggct 1581601 tccagggatt gtcgctccta aaacagctgg gcaaatcctt gcaaacgtct tgagcaagct 1581661 tttggctgaa atacaagctg aggaggggaa ataaggatgt cgtcattaaa aggaaaaaga 1581721 atcgggtttg ggctgaccgg gtcgcattgc acatatgaag cggttttccc gcaaattgag 1581781 gagttggtca acgaaggagc tgaagtccgt ccggttgtca catttaatgt aaaatctaca 1581841 aatacccgat ttggagaggg cgcagaatgg gttaaaaaaa ttgaagacct gactggatat 1581901 gaggccattg attcgattgt aaaggcagaa cctcttgggc cgaagctgcc ccttgactgc 1581961 atggtcattg cgcctttaac aggcaattca atgagcaagc tggcaaatgc catgacggac 1582021 agcccggtgc tgatggcggc aaaagcgaca atccggaaca atcggcctgt cgttctgggt 1582081 atctcgacaa atgatgctct tggtttaaac ggaacaaatt taatgaggct catgtcaaca 1582141 aaaaatatct tttttattcc attcgggcaa gatgatccat ttaaaaaacc gaattcaatg 1582201 gtagccaaaa tggatctgct tccgcaaacg attgaaaagg cactcatgca ccagcagctt 1582261 cagccgattc tagttgagaa ttatcaggga aatgactaaa tttacagaaa atctttccca 1582321 aactaaaaaa ttcggtcatc acccgcatat tctatggtaa aataaaacgt aaaatcatag 1582381 tcaaatcaat tcaatgaagc tgattggcgg aaggagtttt acagatggga agaggtttac 1582441 acgtagctgt tgtcggagcg acaggggctg tgggacaaca aatgcttaaa acacttgaag 1582501 acagaaactt tgaaatggac acacttacat tgctatcttc aaaacgctct gcggggacaa 1582561 aagtcacgtt taaaggccaa gagctgactg ttcaggaagc ttctcctgag agctttgaag 1582621 gggtaaatat tgctttgttc agcgccggcg gaagcgtatc acaagcattg gcaccagaag 1582681 ctgtaaaacg cggcgctatt gttatagata atacgagtgc gttccgcatg gatgaaaata 1582741 caccgcttgt tgtgccagaa gtgaatgagg cagacttgca tgaacacaac ggcattattg 1582801 ccaatccaaa ctgctctaca atccaaatgg ttgcggcact tgaaccgatc cgcaaagcat 1582861 atggcttaaa caaggtcatc gtatcaactt accaggcagt atcaggagcg ggtaatgaag 1582921 ctgtaaaaga gctttacagc caaacacagg cgattttaaa taaagaagaa atagagcctg 1582981 agatcatgcc tgtaaaaggt gacaaaaaac actatcaaat cgccttcaac gcgattccgc 1583041 aaatcgataa attccaagat aacggctata cgtttgagga aatgaaaatg ataaatgaaa 1583101 cgaaaaaaat catgcacatg cctgaccttc aagtagcggc tacatgtgtg agactgccaa 1583161 tccaaactgg gcactcagag tccgtctaca tcgaaataga ccgtgatgac gctacagttg 1583221 aagatattaa aaatctattg aaagaagctc cgggcgtgac acttcaggat gatccaagcc 1583281 agcagcttta tccgatgcct gctgatgctg tcggcaaaaa cgatgtgttt gtaggccgca 1583341 tccgcaaaga cttggacaga gcaaacggtt ttcatttatg ggttgtttct gataacctat 1583401 taaaaggcgc ggcatggaac tctgttcaaa ttgcagaaag cctgaaaaaa ctaaacctcg 1583461 tataaaagag agaattttct aaagacgaat agaagagagt aaggcgctat cagcctgctc 1583521 tcttctgtta cgtccgaata atttggagtg aaaacagtga agataattgt tcaaaagttc 1583581 ggcggaacat cagtaaaaga tgataaaggc cgcaaactgg ctttagggca tattaaagaa 1583641 gcaatcagtg aaggatataa ggttgtcgtt gtcgtttcag cgatgggccg aaaaggggac 1583701 ccgtatgcaa cagattcttt gctcgggctg ctttacggcg atcagtcagc gatttctcct 1583761 agggagcagg atttgctttt atcttgcgga gagactattt cctctgtcgt ctttacaagc 1583821 atgctgcttg ataacggtgt gaaagcagct gcgctgacag gggctcaggc tggcttttta 1583881 acgaatgatc agcatactaa tgcgaaaatc attgaaatga aaccggagcg tttattcagt 1583941 gtgctcgcca atcatgatgc ggtagtcgtc gcaggcttcc agggcgcaac tgaaaagggt 1584001 gatacaacaa caatcggcag agggggcagc gatacgtctg cagccgcact cggagcagct 1584061 gttgatgcgg aatacatcga tattttcacc gatgtagaag gcgtgatgac tgctgaccca 1584121 agagtggtag aaaatgcaaa accgcttcct gttgtgacgt atacggaaat ctgcaacctg 1584181 gcgtatcagg gggccaaggt catttctccg cgtgctgtgg aaatcgcaat gcaggccaag 1584241 gttccgatcc gcgtccgttc gacttattcg aatgataaag gcacattggt gacatcacat 1584301 cactcttcca aggtcggcag tgatgttttt gaaaggctga ttacgggaat cgcccatgtc 1584361 aaagatgtca cgcagttcaa agtgcctgcg aaaatcggcc agtataacgt tcagactgaa 1584421 gtgttcaagg ctatggcaaa cgctggaatc agtgtcgatt tctttaacat tacacctagt 1584481 gaaatcgtct atacggtagc cggaaataaa acagaaacag ctcagcgtat tttaatggat 1584541 atgggctatg atccaatggt gacgagaaac tgcgcgaagg tatcggcggt cggcgcgggc 1584601 attatgggtg ttcccggtgt tacgtccaaa attgtatcgg ctctttcaga aaaagaaatt 1584661 ccgatccttc agtcggctga cagccatacg acgatatggg tgctcgtcca tgaagcggat 1584721 atggttcctg ctgtaaacgc tttgcatgaa gtgtttgaac tttcgaagta aatgtgattg 1584781 aatcatgatg aggtgaataa aatgaatttc ggaaatgtgt ctacagcgat gattacaccc 1584841 tttgacaata aagggaacgt agactttcaa aaactgtcta cactgattga ttacttgttg 1584901 aaaaacggaa cggattcttt agtagtagcg ggaacaactg gagaatctcc gaccctttca 1584961 actgaagaaa aaattgcgct ttttgaatat acggtaaaag aagtaaacgg acgggtgccc 1585021 gttatcgctg gtactgggag caacaacacg aaagattcca ttaagctgac aaaaaaagct 1585081 gaggaagcgg gcgtggacgc tgttatgctt gttaccccgt attacaataa accttctcaa 1585141 gaaggaatgt accagcattt taaagcaatt gcggcagaga catctcttcc ggttatgctc 1585201 tataatgttc ctggccgtac ggttgcttct cttgctcctg aaacgacgat ccgtttggcg 1585261 gcagacattc cgaatgtggt tgcgattaaa gaagcgagcg gagacctcga agcgattaca 1585321 aaaattattg ctgaaacacc tgaagacttc tatgtctatt caggggatga tgctctaacg 1585381 cttccaattc tttcagttgg aggtagagga gttgtgtcag tggcgagcca tattgcaggc 1585441 actgatatgc agcaaatgat caaaaattat acgaatgggc aaacagctaa tgcggcactg 1585501 attcatcaga aactgctgcc gattatgaag gaactgttta aagcgcctaa tcctgctcca 1585561 gtcaaaacag cgcttcagct gagaggtctt gatgtcggtt ctgtgcgtct gcctctagtc 1585621 ccattaactg aggatgaacg tctgagctta agcagcacga tcagcgaact gtaagaaaat 1585681 ttcatacagt gaaacaaacg cggtcattct cacattcagc tgagtttgac cgtttctttt 1585741 acatattggt tttccctaaa ccttctgctt tatcttgttt tctaaattta ctttcagtta 1585801 taataggaac aagtgatgat ggacgggtat gagactagga ggatatagat tttgaaaaag 1585861 aaaaatacag aaaacgttag aattatcgcc cttggcggtg tcggagagat tgggaagaac 1585921 ctttatgtca ttgaaattga ctcagacata tttgtcgttg atgccggcct tatgcatcca 1585981 gaaaacgaaa tgctcggtat tgatgtagtg attcctgaca tatcatattt gattgaacgg 1586041 gctgaccgcg tcaaggcaat ctttttaacg cacgggcacg atgaaaatat cggcggcgtt 1586101 ttttacttat taaacaagct gtccgttcca gtgtacggaa caaaactgac gcttgcactg 1586161 ttaagagaga aattaaaaca atacggacat aaccgaaaaa ctgatttaag agaaattcac 1586221 tccaaatctg tcattacatt tgaatcaaca aaggtatcgt tctttagaac gattcacagc 1586281 attcctgatt ctgtaggtgt gagctttaaa acatcacttg gatctattgt atgcacggga 1586341 gacttcaaat ttgaccaaac acctgcactt aatcagacgt gcgacattgg cgagatcgcc 1586401 aagatcggca atagcggcgt gctcgctctg ctttctgaca gtgcaaatgc ggaacggccg 1586461 ggttacaccc cttcggaagc ggctgtcagc ggagaaattt cggatgcgct gtataattca 1586521 cagaaccggg tgattattgc tgttttcgca tccaatatta accggattca gcaagtcatt 1586581 catgcagcgg ctcaaaatgg cagaaagatt gccgtagccg gaaaaaatct tcaatctgtc 1586641 ctgcagctgg cgagaaagtt aggatatatt gaagcagatg atgaattgtt tatttctgta 1586701 caggatgtca aaaaatatcc gaagcgcgaa gtggccatta ttacagccgg aagccaaggt 1586761 gaaccattag ctgctttgac aagaatggca aacaaagctc acaaacagct gaacattgaa 1586821 gaaggggata cggtggtcat tgcgtcaact ccgattcccg ggcaggaact catttactct 1586881 aaaacagtag atcttcttgc gagagccggt gcacaagtca tctttgccca aaagcgtgtt 1586941 catgtatcag gccacggctc acaagaagag ttaaagctga tgatcaacct gcttaaacca 1587001 aaatatttga ttcctgtaaa cggcgaatac agaatgcaaa aagctcattc aaaaatcgct 1587061 gaagaaaccg gcatgaagcg cagtgacatc ttcttaattg aaaaaggcga cgtcgttgaa 1587121 ttccgcggcc aaaacgtaaa aattggggat aaagttcctt acggcaatat tttaattgat 1587181 ggtttaggtg tcggtgatat cggcaatatc gtattgagag accgccgctt gctttcacag 1587241 gacggaattt taatcgttgt cattacactt gataaacaaa agaaacatct tgtatcagga 1587301 ccagaaatta tcactcgcgg ctttgtttat gtaagagagt ctgaaggtct tatcgtacag 1587361 gctactgagc ttgtacggtc catcgtgaca gaagcgactg aaacatcaaa tgtcgaatgg 1587421 tcaacgctga agcaggcaat gcgggatgct ttgaaccaat tcctttatga aaaaacgaaa 1587481 cgtaaaccga tgatcatccc aattattatg gaagtataat gactgactaa agaccggagc 1587541 tgctccggtc tttatttttt gtccttcaag ccgggattga atgaagtatc tttgttcata 1587601 atacaaagag aaactcggaa aggatgaaag cgagatggat catcgtatgg aaaacacaga 1587661 agaagagcgt cctgaaaaaa atgatgcgaa ggacagcatt atgaataaaa tacagcagct 1587721 tggtgaaacg acgcttccgc agctgcccca agatacaaat attcattgtc tgaccattat 1587781 cggacaaatt gaaggccatg ttcagcttcc tccgcaaaac aaaacaacaa aatatgaaca 1587841 tgtcatcccg cagattgtgg caattgaaca aaatcccaaa attgaaggct tgctgatcat 1587901 attaaatact gtcggaggag atgttgaagc tggtcttgcc atagcggaaa tgcttgcatc 1587961 tttatcgaaa ccgaccgttt ctatcgtgct tggcgggggg cattcaatcg gcgttccgat 1588021 tgctgtatcc tgtgattaca gctatatcgc cgaaacagca acgatgacga ttcatccagt 1588081 taggctcacc gggctggtca tcggggtgcc gcaaacgttt gaatacctgg ataagatgca 1588141 agaaagagtt gttaaatttg tgacaagcca ttccaatata accgaagaga agtttaaaga 1588201 gctaatgttt tcaaaaggaa acttaacacg cgatatcgga acaaatgtag tcggtaagga 1588261 tgcagttaaa tacggattga tcgatcacgc aggcggtgtc ggacaggcaa tcaataaact 1588321 gaatgagctc atcgatgaag caaggaaaga agaaggacgg atgattcaat gattctttat 1588381 accgtgatgc ctcaggaaat tgtgtttgca gaacagaacc aagagacaag cgcacatgag 1588441 caaattgaat ataaaggtgt accgcttcta gtcgaaatga aagggaatga agcggaagtc 1588501 attcaaatca tgagcaccaa tccaatgcat tttctgcatc cggacatttc accgggacaa 1588561 aagctgaaat taaacgtata agaatccaac ccttttttaa gggcaaaata tgctataata 1588621 ggggaatcct acagaaaaaa cgcagcctgt aaacggctgc tttcttcatt atgtatgaac 1588681 ttacattttt taacgcagta aggtgatgag tgtggcaaag aaaaaacgaa aatcaagaaa 1588741 aaaacaggcg aaacagctca atataaaata cgagctcaac ggattgctgt gtatagccat 1588801 ttcaattatc gcaatcttgc agctgggggt agtcgggcaa acgtttatct atttgttccg 1588861 cttttttgct ggagagtggt ttattttatg cttgttaggt ttattggtgt taggagtctc 1588921 actgttttgg aagaaaaaaa ccccaagcct tttaacgaga cgaaaggccg ggttgtactg 1588981 tattatcgca agcatattgc tgctttctca cgtgcagcta tttaaaaatt tgacgcacaa 1589041 agggtctatt gagtctgcaa gcgtggtgcg caatacgtgg gaattgtttt taatggacat 1589101 gaatggcagc tctgcttcac ctgatttagg cggagggatg atcggtgcgc tgctgtttgc 1589161 ggcttcacac tttttgtttg cgtcgactgg ttctcagatc atggcaattg tcatgatttt 1589221 gatcggaatg attttagtaa caggacgctc gctgcaagaa acgctaaaaa agtggatgag 1589281 cccgattgga cgttttataa aagaacaatg gttagcattt attgatgaca tgaaatcctt 1589341 caaatcaaat atgcagtcat cgaaaaaaac gaaagcgccg agcaaaaaac aaaaaccggc 1589401 ccgcaaaaaa cagcaaatgg aaccggagcc tcctgatgaa gagggggatt atgaaacagt 1589461 atcgcctctt attcattcag agccgattat ctcaagcttt tctgatcgta atgaagagga 1589521 agagtctcca gttatagaaa agcgcgccga acctgtgtcg aagccgcttc aggacatcca 1589581 accggagaca ggtgatcagg aaactgtttc tgctcctcct atgaccttta cagagctcga 1589641 aaataaggat tacgagatgc cgtcactgga tttgctggca gatccgaagc ataccggcca 1589701 gcaggctgat aaaaagaata tttatgaaaa tgcgagaaag cttgaacgca cattccaaag 1589761 ctttggcgta aaggcgaaag tcacacaggt tcatctcgga ccggccgtaa caaaatatga 1589821 agtatatcct gatgtcggag tgaaggttag caaaattgtc aatttaagcg atgatttagc 1589881 gcttgcgctt gctgcgaagg atatcaggat cgaagcgcct ataccaggca aatcagcaat 1589941 cggaattgaa gttccaaacg cagaagtggc aatggtttcg ctgaaagaag tgctggagtc 1590001 taaattgaat gacagaccgg atgcgaagct gttaattgga ctcggccgca atatttcagg 1590061 tgaagctgta ttggctgagt taaacaagat gccccacctt ttggtcgcag gcgcaaccgg 1590121 tagcgggaaa agtgtctgtg tcaacggcat tattacaagt attttaatgc gggcgaaacc 1590181 gcatgaagtg aaaatgatga tgatcgatcc taaaatggta gagctaaatg tctacaacgg 1590241 gattccgcat ttgcttgctc ctgttgtaac cgatccgaaa aaagcgtcgc aggctttgaa 1590301 aaaggttgtc aatgaaatgg agcggcggta cgaattattt tctcatacgg gtacaagaaa 1590361 tattgaagga tacaatgatt atataaaacg cgccaacaat gaagaaggag cgaaacagcc 1590421 agagctgcct tatattgttg tcattgtgga cgagctagcc gatctcatga tggtcgcttc 1590481 atctgatgtg gaagattcga ttacgagatt gtcccaaatg gcgcgggctg ccggcatcca 1590541 tcttattatt gcgacacagc ggccatcggt ggatgttatc acaggggtga tcaaagcgaa 1590601 cattccgtca cgaatcgcgt tcagcgtatc ttcacagacg gattcaagga ccattcttga 1590661 catgggtggc gctgagaagc ttcttggccg cggcgatatg ctgtttttac ctgtaggggc 1590721 taacaaacct gtccgtgtgc agggagcatt tttgtcggat gacgaagtgg agaaggtcgt 1590781 cgaccatgtg attactcagc agaaagcgca atatcaagaa gaaatgattc ctgaggagac 1590841 gacggaaact cattccgagg ttactgatga actttatgat gaagctgttg aattaatcgt 1590901 cggcatgcag acggcatctg tttcaatgct gcaaagaaga ttcagaattg gctatacgag 1590961 agcggcgcgc ctgattgacg caatggagga acgcggtgtt gtcggaccgt atgaaggcag 1591021 caaacctagg gaagtattat tatcaaaaga gaaatatgat gagctctctt cttaatgaag 1591081 ggagttccgc tttctatagt tgtcaataat gatattatgt aaactgatca cctttctatt 1591141 tattttttcg acaaaacatg atatagttgt cccaattgtt caataatttt tatcgaaagt 1591201 ggtttacgga ggggaaacat gtctacaaaa gctgataatc ggcacttgta tttgaaagta 1591261 attgaacgaa ttaaagagga tataaaaaat gggatctaca ctgagaagga aaagctgcct 1591321 tctgaatttg agctttccaa aaagcttggt gtcagcagag cgacgctaag agaagccttg 1591381 cggatactgg aagaagagca tgtgattatc agaaggcatg gtgtaggcac ttttgtccat 1591441 tctaagccgt tatttctttc gggtattgaa cagctgaaca gtgtaaccaa gatgatagaa 1591501 caggcgaata tgacccctgg cacgattttt ctatcatcac aagtgcttat gccgtctgaa 1591561 gatgatacga agagatttca cttggcagaa gggcaagaac ttttttacct tgaacgagtc 1591621 aggacagctg acggacagcc gattgtgtat tgtatagaca aaattccgat gaatattttg 1591681 ccgaattctt tttctcatca gcaagaatct atgtttgacc tgctagagaa aaattcaggc 1591741 tccgtaatca gctatgcagt aactgatata gaaccgatcg gctatcacga taccatttct 1591801 ccagtgcttg aatgcgatcc ggaaacagct cttttgctgt taaaacaaac ccattacgat 1591861 cagcacgata aaccggtgct ttattcttta aattatttta gagcggataa attcagattt 1591921 catgttttgc gtaaacgatt ctaaaaacgg acgcctgtat gtgtctgttt ttttatttgc 1591981 actgattcat gtttctttgt acatactttc attccggtta acgcaatata taagggatga 1592041 caagaaagtg aatgggtgaa aatgttgaga gagaaaaatg gaatgaaaaa tattattgca 1592101 ttgtcttctg tcccgcttgt gatgacactc gggaactcca tgctgattcc tgttcttccg 1592161 atgatggaga aaaagctgtc tgtgacttca tttcaagtat ctttaatcat tactgtatat 1592221 tcagtagtag caattatttg cattccgatt gccggatatt tgtcggatcg tttcgggaga 1592281 aaaaaaatat tgcttccatg cctcctcatt gcaggattgg ggggagccgt agctgctttt 1592341 gcctcgacct atatgaaaaa tccttatgct atgatcttgg cggggcgggt tcttcaaggc 1592401 attggttctg caggtgccgc tccgattgtc atgccgttta tcggcgacct gtttaaagga 1592461 gacgatgaaa aggtcagcgc gggtcttggc gatattgaaa ccgccaacac gtcagggaag 1592521 gtactgagtc ccatacttgg agccttactg gcttcttggt attggtttgt accgttttgg 1592581 tttattccgt ttttctgttt gatcagcttt ttgctcgtat tgtttttggt ggccaagcct 1592641 gaagaagatg aagatgcgcc tgctgtttct gagtttatta agagtgtgaa gaaaattttt 1592701 aaacaggatg gtcgctggct ttatacggtc ttcattatcg ggtgtgtcat tatgtttttg 1592761 ttatttggcg tattatttta tttatcagat acgctggaga acaagtatgc tattgacgga 1592821 gtagctaaag gcggattact ggcaatccca cttttgtttt tgtcaaccag ttcttttata 1592881 gctggcaaaa agatcggtaa agataaaggc cgaatgaaat tttgcgttgt tacaggaatg 1592941 attctgttaa ccctttcgtt tattgccttg tggtggaacc acagttttta ttttttattt 1593001 gtctttttaa gctttggcgg gattgggatt ggaatggctc ttcctgcttt agatgcattg 1593061 ataaccgaag ggattgaaag tgaacaatgc ggaaccattt cctcctttta caatagcatg 1593121 cgctttatag gagtagctct cggtccacct gtttttgctg cattaatgtc taatgcaaac 1593181 tggattattt tcatactctc ggcgttttgc agcatcgttt ctttattttt agtgctcttt 1593241 actgtagatg ctaaaaaaag tgaagaagaa aaaaacttag ggacggtcta gccagccgtc 1593301 tttttttgcg ctttcttgca cagtttacaa ctgtacctat acagcatgcg gaggttattg 1593361 tttccttata aatcctacag ttgctataat tacatgaaag agtgtttctg cggatgctga 1593421 aaattggtca taatacatac taattaagaa atgaacgaag gaggttccat atgtcatatg 1593481 ttaatgaact caaatcaaag cacggcggtt taaccgcaca cattgtaaaa acagaaaaat 1593541 tcaaaaccgt ctcgcttatt tttaagatgc ttgcgccgct gacaaaggat caagtcacca 1593601 aaagagcgct tctcccgcat gtgcttcttc gcggaacgaa aagccatccg aaaaccgcag 1593661 gattgcgttc atacttggat gagctgtacg gcacgtcagt atcggctgat cttacgaaaa 1593721 aaggagagcg gcatgtcatt acgttcaggc ttgaaatccc gaatgaaaaa tatttaaaag 1593781 accaaacgcc gcttctcgag aaagggctcc agcttctcgc agaactcgtc ttttcacctg 1593841 ctttggaggg agacgctttt cagtcacaat atgtggctca agaaaaacgg acgcttaagc 1593901 aaagaatcca agccgtctat gatgataaaa tgcgttattc gaatttaagg ctgatacagg 1593961 aaatgtgcaa aaatgatcct tacgcgcttc atgtcaatgg tgaaatcgac gatgtcgatg 1594021 acattacggc agagcaatta tacgaaacat accaaagcgc tatccaaaaa gaccagcttg 1594081 atctatatgt tgttggcgac gtggacagta accaggtaca atcggcaatt gataagtatt 1594141 tcaaaacaga agagcgcact cttggcatga ttgaaaacaa tcacgctgat gaaaaagttc 1594201 agccaaaaga agtaattgat gaagaggatg tcaagcaagg aaaactgaat atcggctacc 1594261 gcaccagcat cacttataca gatcaggatt atcctgcttt acaagtgttt aacggattgt 1594321 tcggcggatt ctctcattct aaacttttca ttaatgttcg ggaaaaagcc agtcttgctt 1594381 actacgcggc ttcgcgtata gaaagtttta aaggcttgtt aatggtgatg tcaggcattg 1594441 aagtgaaaaa ttttgaacag gcggtttcga ttattgctga gcaattccag gcaatgaaaa 1594501 atggcgattt cagtgagcag gatatagcac agacaaaggc cgttattcga aatcaagtgc 1594561 tggaaacgat tgatacagca tacggtttat ctgagttttt atatcagcag gccgctgctc 1594621 aagtcgagat tcctatcgaa gactttcttg ccaatattga gaatgtcaca aaagaggata 1594681 tcattaaagc cggcgaaaag attcagcttg atacgactta tttcttaaaa gggacggagg 1594741 gtgcatcttg atcaaaccaa tcgaatatga acagcttcag gagacgctgt atcatgaaaa 1594801 aatgtccaac ggccttgatg tttacgtttt gccgaaaaaa ggcttcaaca agacatatgc 1594861 ggtctttaca acaaagtacg gctcgataga taaccggttt gtccctttag gtaaaaacga 1594921 gatggttcac gtgccggacg ggattgctca ctttcttgag cacaagctgt ttgagaaagc 1594981 ggacggagac gtttttcaag atttcagcaa acagggggct tctgccaatg cgtttacgtc 1595041 atttacaaga acggcttacc ttttctcaag cacatcaaat gttgaacgca atttagagac 1595101 gcttatcgat ttcgtacagg acccatattt tactgaaaaa acggttgaaa aggaaaaagg 1595161 gattatcggg caggagatta atatgtacga cgataaccct gattggaggc tttacttcgg 1595221 ggtcattgaa aacatgtaca aagagcatcc tgtcagaatt gacatagcgg gaacagtgga 1595281 aagcatttca catattacaa aagaccttct ttatgaatgc tatgaaacgt tttatcaccc 1595341 gagtaacatg ctccttttca ttgtcggccc tgtagatcct gaagcgatta tttctcaggt 1595401 aagagaaaac caggggaaaa agccgtatac tgatcagccg gagatcaaac gagaagaagt 1595461 gaaagagcaa gaagcggttt tccgaaaaga aaaagagatc aaaatgaacg tgcagggacc 1595521 gaaatgcctt gttgggctga aatccaaaaa tccgtttaaa ttaggcaaag agctcttaaa 1595581 gcatgaactt tcaatgaact tattgcttga agctcttttt ggcaaaagct ctgcccagta 1595641 tgaatcactt tatgaaaaag gatatattga cgaaacgttc agctttgatt ttactgctga 1595701 atatgggttc ggttttgcgg cgatcggcgg agatacgcct gagcctgatc aattggctga 1595761 agacatttca agcatgcttt tgcgcgccgg tgaactgatt actgctgaaa agattgaact 1595821 tgccagaaag aaaaagatcg gcacattctt aaaagcgctg aattcccctg aatacatcgc 1595881 caatcaattt acccgttatg cgttcttgga tatgagcctg tttgatgttg taacggtact 1595941 cgagcagatt accctcgagg atgtccagaa cgtaatacaa gaggaaatcg ctgcagacag 1596001 actgactgtc tgcaaggttg ttcctaaatc ataaacaaaa catccctcca gtgtgagggg 1596061 tgtttttctg cggaaagaag gaaagaggat gaacaaaaca gcactaatca ccggagcaag 1596121 cggcggcatt ggcaaaagca tcagcgaaac ccttgcagct agaggataca atctgctgct 1596181 gcattacaat acaaatcaaa acgcggcagc ggagcttgct gaaaaactaa gtcagatgtt 1596241 tggcgtaaat gcggagatat tacaagctga cctgtccgcg caagatggag cagataagct 1596301 gacaagttca attgttcagc cgattgatgc gattgtttta aacagcggac gaagccattt 1596361 tgggctgatt acggatgtag ataacgcaac ggtccaggaa atggttcagc ttcatgtggc 1596421 gagtccgtat atgctgacga gaaaccttct gccaggcatg attcggaata aatcgggagc 1596481 gattgtggct gtcagctcga tttggggaga gactggagca tcctgtgaag tgttgtacag 1596541 catggcaaaa ggagctcagc attcatttgt aaaaggattg gctaaggagc tggcgccaag 1596601 cggaatcaga gtaaacgccg tagcgccggg tgcagttgat acaaatatga tgaatcaatt 1596661 taccccggct gaaaaagaag agatcgctga tgagattccg atcggccggc tggcccggcc 1596721 gcaagaaatt gcggatgcaa cagcttttct cctgtctgaa aaagcgtcat atatcaccgg 1596781 ccaaattctg tcggtgaatg gcggctggca ctgctgatcc gaaaatattc ggtgtatagt 1596841 ttcttttgcg aaggacacaa taatcttgta acttcacatg aaatggagga aacaagcatg 1596901 tcagtattag aaaactggga tagctggaaa aacttccttg gcgaccgtct gaactatgcg 1596961 caagataaag gtatgagcca ggatacgatt acagatcttg cgacagaaat cggcagctac 1597021 ttggctaatg aagtggaatc taagaacgag caggaaaaag tgctggcaga tctttggagt 1597081 gtagcatcaa aagatgaaca gcacgccatt gccaatatga tggttaagct tgttgaaaat 1597141 aacagcactc actaggaaga gaggggattt ttcctctctt ttttatgttt tcctcatcac 1597201 agcaacattc ttctttctaa ttagagaaaa atgctttatg ataaaggaag gtaaaatttt 1597261 gccacaatga agggggtata tcatttggca aagctcgaat ggtattttga atatgaaatt 1597321 caagtgaacc gccccggact gctcggggat atttcatctc ttcttgggat gctttctatc 1597381 aacatcgtaa cgataaacgg cgtcgatctt tccagaaggg gaatgctcct caggtgccgc 1597441 catatagatc aaattaaacg attagaatca atcttaaaaa cgatggaaac aattaaagta 1597501 acgaagctta gagaaccgag gcttcgcgac cgtcttgccg tacgccacgg ccgttatatt 1597561 caacgggatg ccgatgacaa gaaaacgttc cgctttgaac gggacgagct tggcttatta 1597621 gtcgatttta tggccgaatt gttcaaaaaa gaaggccata aattaatcgg aatcagaggt 1597681 atgccgcgtg tcgggaaaac ggaatcgatt gtagcctcta gtgtgtgcga gcaaaaggtg 1597741 gctgtttgtg tcatcaacct tgctgaagca gacgataaga agccagctga ttgccgatga 1597801 atacagcact gaaaatgtct ttatcgttga cggaattgtg tcaacacgaa gagggtcaga 1597861 acgccatctc cagctggtcc gagaaatcat gcggctgcct gcaacaaaag tggtggagca 1597921 tccggacata ttcgttcaaa atacagagta tacactagat gactttgatt atattattga 1597981 actgagaaat gaccctgatg aggttattac atatgaacat gccgaggaac cccaaatgtt 1598041 tgatcaatcc gggttttcaa gctttgattt ttaaaattgg aaggtgtttg ttgtgactga 1598101 actaggaatc cggctcaaag aagccagaga ggaaaaagca atgtcattgg atgatctcca 1598161 agcggcaaca aagattcaaa aaaggtattt aaccgccttg gaggaaggaa actatgacat 1598221 tattccgggg aagttttatg ttcgggcatt catcaagcaa tatgcagaag ccgttgggct 1598281 tgatgcggat cagctgtttg aggagcataa aaaagatatc cctaatacgt atcatgatga 1598341 tgtgtctgaa aagatctccg gcatgaatct tcaaaaggaa atgccaaagc cagcatctaa 1598401 ggcgctggag ctgctgccaa caatacttgt tattctcggc gtgattgtcg tgattgccat 1598461 tgtgtacgcg atcattcaat ttgccaatca caaaaacagt gatgatcaca atgcggcatc 1598521 agaaaaagca attacgcaaa gtgagagcaa gtacgaaatc cctaaagatt caacgctgaa 1598581 agagaatcaa aataacagct ctgaaaaaga gacagacact aaaaaagaaa cgaaagaaaa 1598641 cgaagataag aaaaaagaaa atgacagtga gaagctggag attaaagctg ctggcactga 1598701 aggatcgtta acgacttatg aagtgtccgg cgctgataaa atcgagctgg aactgaaggc 1598761 atcagacagc tcctggatta gagtgcgcga tgaaaacagc agctctttaa aagaaggaac 1598821 gctgaaaaaa gacgaaacct ataaaaaaga cataactgat cagaaacaag ttgatatccg 1598881 caccggatat gcacctaatc tgaaaataaa aatcaacggt aaggttcttt catatgaact 1598941 tgatccgaaa aaagtgatgg cacaaaccat aaagattgta aataaaaagg aagaaaagtc 1599001 atcttaatta ccagatgact tttcttcacg tccgagtatg aaattggagg ggctttatgt 1599061 ttaacttacc aaataaaatc acactagcta gaatcgcatt aatcccaatc ttcatgatta 1599121 tcatgctggc gccgtttgac tggggcaggc tcgaagttgg agacgaatcc atcccggtcg 1599181 cacatttggc gggggccatt ctatttatta ttgcatctac aacagactgg gtggacgggt 1599241 attatgcccg aaaattaaat ctcgtaacaa acttcgggaa atttcttgat ccgcttgcgg 1599301 acaaactgct cgtatccgca gcgttaatta tccttgttca atttgatctc gctccagctt 1599361 ggatggtcat tgtgattatc agcagggagt ttgccgtgac aggtttaagg cttgtcttag 1599421 ccggaacagg agaagtcgta gctgctaaca tgcttggtaa aatcaaaacc tgggcacaga 1599481 ttattgcggt atctgcattg cttcttcata atcttccatt tgaacttgtg tcattcccgt 1599541 ttgcagactt ggcgctgtgg gtagccgtct tctttactgt cgtctcaggc tgggaatatt 1599601 tctctaaaaa ttgggaagcg ttaaaaacat ctaactaaga aagaaggact tcgtcatgga 1599661 atttccaaaa aaagcagaaa taattgcagt cggttcagag ttgctgcttg gtcaaatcgc 1599721 caatacaaat gctcaattta tcagcaaaca gctcgctgaa atcggggtca acgtatttta 1599781 tcatacagcg gtcggagata acccggagcg gctgaagcag gtcatccgca ttgctgaaga 1599841 acgctctgac ttcattattt tttcaggagg gcttggaccc acaaaagatg atctgacgaa 1599901 agaaacgatt gcaaatacgc tgggacgtcc gcttgtgtta aatgatgagg cattccaatc 1599961 cattgaggac tatttcaaac gaacaaaacg cacgatgtca cctaataacc gaaaacaggc 1600021 gcttgtgatc gaaggctctg acgtgctggc gaatcacttt ggaatggccc cgggaatgct 1600081 cacagagcat gaatcgcgct attatatgct tcttcctgga ccgccgagcg aattgcgtcc 1600141 aatgtttgaa aacgaggcaa agcctcttct gctgaaaaag atgggttcaa atgaaaaaat 1600201 tgtgtcaact gttcttcgct ttttcggtat cggtgaatct cagcttgaag ccgatttgga 1600261 agatattatt gatgcacaaa ccaatccgac aattgcgcct ttggcggctg atggagaggt 1600321 gacgctgcgt ctgacagcca aacacgccga tgaaaaggaa acagagcgtc tgttaaaaga 1600381 aacagaggcc gttatcttag agcgtgtcgg tgaatttttc tatggttacg atgatacttc 1600441 tcttgtaaaa gagctatcta tagcatgtaa ggaaaaaggc ataacaattt ctgcggcaga 1600501 aagctttacc ggagggctgt tttctgaatg gctgacggat catagcggtg cctcaaaatt 1600561 atttgccggg ggcgttgttt gctatacaaa cgacgtgaag cagaatgtgc ttggtgtcaa 1600621 gaaggaaaca ttagatcgtt ttggggcggt cagcaaggag tgcgcatccg aactggctaa 1600681 gggtgttcaa aaactcactg gcagcgatat cggcattagc tttactggtg tagcaggacc 1600741 tgatgctcaa gaagggcatg agcctgggca tgtgtttatc ggcatttccg caaatggtaa 1600801 agaagaggtt cacgagtttc actttgcggg ctccagaacg gggatcagaa aacgcggcgc 1600861 taaatacggc tgccatttaa tcttaaagct tttagagcaa aaataatatt ttcagcacat 1600921 tatcctccta agaaaacatg atttctctga tacattatga tattttgata ggaatcacgc 1600981 caagaaaaaa tccgaatatg cgttcgcttt tttcttggca aatcccttca aacagggtat 1601041 agtatatgta gtggtaacat aaaggaggaa aaaatagaat gagtgatcgt caggcagcct 1601101 tagatatggc tcttaaacaa atagaaaaac agttcggcaa aggttccatt atgaaactgg 1601161 gagaaaagac agatacaaga atttctactg taccaagcgg ctccctcgct cttgatacag 1601221 cactgggaat tggcggatat cctcgcggac ggattattga agtatacggt cctgaaagct 1601281 caggtaaaac aactgtggcg cttcatgcga ttgctgaagt tcagcagcag ggcggacaag 1601341 ccgcgtttat cgatgcggag catgcgttag atccggtata cgcgcaaaag ctcggtgtta 1601401 acatcgaaga gcttttactg tctcagcctg acacaggcga gcaggcgctt gaaattgcgg 1601461 aagcattggt tcgaagcggg gcagttgaca ttgtcgttgt cgactctgta gccgctctcg 1601521 ttccgaaagc ggaaattgaa ggcgacatgg gagattcgca tgtcggttta caagcacgct 1601581 taatgtctca agcgcttcgt aagctttcag gggccattaa caaatcgaag acaatcgcga 1601641 ttttcattaa ccaaattcgt gaaaaagtcg gtgttatgtt cgggaacccg gaaacaacac 1601701 ctggcggccg tgcgttgaaa ttctattctt ccgtgcgtct tgaagtgcgc cgtgctgaac 1601761 agctgaaaca aggcaacgac gtaatgggga acaaaacgaa aatcaaagtc gtgaaaaaca 1601821 aggtggctcc gccgttccgt acagccgagg ttgacattat gtacggagaa ggcatttcaa 1601881 aagaaggcga aatcattgat ctaggaactg aacttgatat cgtgcaaaaa agcggttcat 1601941 ggtactctta tgaagaagag cgtcttggcc aaggccgtga aaatgcaaaa caattcctga 1602001 aagaaaataa agatatcatg ctgatgatcc aggagcaaat tcgcgaacat tacggcttgg 1602061 ataataacgg agtagtgcag cagcaagctg aagagacaca agaagaactc gaatttgaag 1602121 aataaaaata aaataagttt caaatgatac aaaaggctga gtgaaaaact cagctttttt 1602181 gtattttgca aaaaaatgat aaaaatattg ctttttttga caactttttt agggctttat 1602241 tcgtctaaca aaacgtgtgc aaaatggaat ttattttggg aggaaaaaat gaatgacaag 1602301 cccaacccgc agaagaactg cgaaacgcag acggagaaaa ctaaataaaa gaggaaaact 1602361 gttgtttggt cttttagcag tgatggtttg cattacgatt tggaatgctc ttcatcgaaa 1602421 tagtgaagaa aacgaaccat ctcaagaaac tgcagcggtt tcaaataccg atcagaaaaa 1602481 agaggtcaaa aagaaaactg ccaaaaaatc agaggaacaa atcaaaacag tggatcgaaa 1602541 ccaaaaaatc agcaattatt taaaagagat cggtttcagc ggaacagcca tgattgtcag 1602601 aaatggagaa atcgtaacaa ataaaggttt tggctatgct gaccgtaaac actacattca 1602661 aaataatcca ttgacatctt tttatgtcgg ttcatcacaa aaagcgctga ttgcaactgc 1602721 tattttgcag cttgaggaaa aggggaaact tcagacaagt gatccggtaa gcacgtattt 1602781 acctcatttt cccaacggac aaacgattac tttgaagaat ctgcttacac atacatcggg 1602841 gataaacgga catattgaag gaaacggcgc cattactccg gacgatttaa taaaagatat 1602901 agaacttcag ggaatcaaac gtcagccggg cgtatgggac tacaaggatt ccaactattc 1602961 tgttcttgct tatattattg ctgaagtaag cggtgagccc tatgaacagt acataaagaa 1603021 tcatattttt aaacctgcgg gaatgacgca tgcaggcttt tacaaaacat atgaaaaaga 1603081 accttatcct gccgtcgggt ataagatgga gggcagcaaa acagttacac cgtatatacc 1603141 tgatttatcc cagctgtatg gagcgggtga tatttatatg agcgctatag atatgtacaa 1603201 atttgaccaa gcgctgatag acggaaaact gtattcgcaa aaaagctatg aaaagatgtt 1603261 tacgccaggg agcagctcca catacggcat gggattttat gttgctcccg gaagctattc 1603321 aaaccatggt gttatgccgg gcttcaatat cttgaacagc tttagcaaat ctgggcaaac 1603381 cattgttatt ttgttctcaa acattcaaaa taatgctaaa ttgggccaag tgaacaataa 1603441 aatataccag cttctaaatc aagaatgatt ggcgatcttc ttttggatga attgcattcg 1603501 gcacgtgaaa agaagactgg cctgcaaacg ttaagatggc aagcttgaca agtatttccg 1603561 acacatttac aatgaagttg taacatttgt ttttttaaca tgattgttaa accatttaaa 1603621 cttgacaagg gcgatgaaca cactcattcc ctgtgaaggt tctgtatgtt gagaaaacta 1603681 gacaatgtac atgccgacac tttttaagca acaaccaagt tcatagcaag aggaggtgaa 1603741 agtatgaccc caattatgat ggttctcatc tccattttgc tgattctact cggtttagtt 1603801 gttggctact ttgttcgtaa aaccattgcc gaagcgaaaa ttgcgggcgc acgcggtgca 1603861 gccgagcaaa ttcttgaaga tgcgaagcgt gatgctgaag cactgaaaaa agaagctctg 1603921 cttgaagcaa aggatgaaat ccacaaactt cgaatagatg ctgaacagga agttcgtgaa 1603981 agacgaaatg agcttcaaaa acaagaaaac cgtttactcc aaaaggagga aaaccttgat 1604041 cgcaaacatg agggaattga taaacgggaa gcgatgttgg agaagaaaga tcattctctg 1604101 aatgaacgac aacaacatat tgaagagatg gaaagcaaag tggatgagat gattcgtatg 1604161 cagcagtctg agttggaacg aatttcgagt ctgactcgtg acgaagcgaa acaaatcatt 1604221 cttgagcggg ttgaaaacga gctttcacat gacatcgcca tcatgacaaa agaaactgaa 1604281 aaccgtgcga aagaagaggc ggataagaaa gcgaaaaaca ttctttcact cgccttacag 1604341 cgctgcgcag cggaccacgt tgccgaaaca acggtatcag ttgtcaatct tccaaatgat 1604401 gagatgaaag gacgtatcat cggacgggaa gggcgtaaca ttcgtacgct tgaaacgctg 1604461 acaggaattg acctgattat tgatgatacg cctgaagctg tcattctttc cggatttgat 1604521 ccgatcagac gtgagacagc cagaattgct cttgataaac tcgttcagga tggccgtatt 1604581 catccggcac ggattgaaga aatggttgaa aaatctcgcc gcgaggtcga tgactatatt 1604641 cgtgagatgg gtgagcaaac gacatttgag gttggcgttc atggcctcca cccagatctc 1604701 atcaagatcc tcggccgctt aaagttccgt acaagctacg gtcaaaatgt gcttaagcat 1604761 tccatggaag tcgcattctt ggccggtcta atggcatcgg agcttggtga agacgcaaag 1604821 cttgctaaac gtgcgggtct tcttcacgac atcgggaaag caattgacca tgaagtagaa 1604881 ggaagccacg ttgagatcgg ggtagagctt gcgaccaaat ataaagagca cccagtcgtg 1604941 attaacagta ttgcatcaca ccacggggac gaggagccga cttccattat tgctgtactg 1605001 gtagctgcag cagatgcgct ttccgctgca agacctggcg caagaagtga gacgctcgag 1605061 aattatattc gaagacttga aaaacttgaa gaaatttctg agtcctacga aggtgttgaa 1605121 aaatcatttg ccattcaggc tggacgcgaa gtgcgaatta tggtgaagcc ggattcaatt 1605181 aatgatcttg aggctcatcg actggcgcga gatatccgca agcgaattga ggacgagctc 1605241 gattatccag gtcatattaa ggtgacagta atcagagaga ctcgagccgt agagtatgca 1605301 aaataaagtg atgcgctaag catcacttta tttttttgac ggcaaggaat tttcaagaag 1605361 aaaggattta caaaatgaga attttattta tcggagatgt tgtcggttca ccgggccgtg 1605421 acatggtcaa agaatatgta ccaaagctaa aaacaaaata taagcctcac tttaccatta 1605481 ttaatggtga aaacgccgca catggaaaag gcctgacgga aaaaatttat cacagcttaa 1605541 tccagtccgg cgcagatgca atcacaatgg ggaaccacac atgggacaaa aaagaaatat 1605601 ttgattttat agatgacgtt ccgaacttgg ttcgcccggc aaactttcct gaaggaacac 1605661 cggggaaagg gatcacatat gtgaaagcaa acggcaaaga actagcagtc attaatttgc 1605721 agggacgtac gtttttgccg ccgcttgatg acccgttttt aaaagcggat gaattgatcg 1605781 cagaagctgc gaaaagaaca ccgtacattt ttattgactt tcatgccgaa gcgacaagtg 1605841 aaaagctcgc acttggctgg tacacggatg gacgggcatc ggctgtagta ggaactcata 1605901 cacacgtgca aacagcggat aaccgcattt tgccgaaggg aacggcatat attactgatg 1605961 tgggaatgac tggcccgtat gacggtatac tggggatgga cagagagacg attattaagc 1606021 gattcaaaac gaaccttcca gtccggttta ctgtcgctga aggaaaaaca acgctcagcg 1606081 gagttgtcat tgacattgac gatcaaacga aaaaagccgt gaaaattgag cgtattttaa 1606141 tcaacgatga tcacatgttc tttgaatagt tgaacatatg gttattttat aaaaatatta 1606201 aaaagaaaag caggaatata gcaactcctt agtgaatata gtaaaaatgg aaggtagccc 1606261 gctatttttg aaaagcattg tggggatggc tttttggata gcaacatcta ataatgattg 1606321 ttctaatgaa cactcactta tccattgtaa aactaagggg gagcagaaat ggaaatctta 1606381 aaagtttcag caaaatcgag tccaaattca gtggcaggtg cgcttgcagg cgtgttgaga 1606441 gagcgaggag ccgccgagat tcaagcgatc ggagcgggtg cattaaacca ggctgtaaaa 1606501 gctgtggcga ttgccagggg atttgtggcg ccaagcggcg ttgatttgat ttgtattccg 1606561 gcttttacag atattcaaat cgatggggaa gaaagaacag cgattaaatt aatcgtggag 1606621 cctcgctaaa aacaaataaa gcattctcaa cctgtttgcg taatgcaaac aggttgtttt 1606681 tcatttattg tgatattttc tcccgatagt atttttagca cataaatgag cgaatataca 1606741 aaatcagaaa tgagctaaaa cgtttcaaaa aaaatttccg cccatttttc aagacagata 1606801 cttttgtcct tctggaaaag acagttctgt ttacgcttat tccatatcat ggtacaatcc 1606861 gaatataaca agaatttttc aaggaggatt gtacatgcag agtggaaaga tgaaagctct 1606921 aatgaaaaag gacggggcgt tcggtgctgt gctgactgaa gttcccattc ctgagattga 1606981 taaacatgaa gtcctcataa aagtgaaagc cgcttccata tgcggcacgg atgtccacat 1607041 ttataattgg gatcaatggg cacgtcagag aatcaaaaca ccctatgttt tcggccatga 1607101 gttcagcggc atcgtagagg gcgtgggaga gaatgtcagc agtgtaaaag tgggagagta 1607161 tgtgtctgcg gaaacacaca ttgtctgtgg tgaatgtgtc ccttgcctaa caggaaaatc 1607221 tcatgtgtgt accaatactg ctataatcgg agtggacacg gcaggctgtt ttgcggagta 1607281 tgtaaaagtt ccagctgata acatttggag aaatcccgct gatatggacc cgtcgattgc 1607341 ttccattcaa gagcctttag gaaatgcagt tcataccgta ctcgagagcc agcctgcagg 1607401 aggaacgact gcagtcattg gatgcggacc gattggtctt atggctgttg cggttgcaaa 1607461 agcagcagga gcttctcagg tgatagcgat tgataagaat gaatacaggc tgaggcttgc 1607521 aaaacaaatg ggagcgactt gtactgtttc tattgaaaaa gaagacccgc tcaaaattgt 1607581 aagcgcttta acgagtggag aaggagcaga tcttgtttgt gagatgtcgg gccatccctc 1607641 agcgattgcc caaggtcttg cgatggctgc gaatggcgga agatttcata ttctcagctt 1607701 gccggaacat ccggtgacaa ttgatttgac gaataaagtg gtatttaaag ggcttaccat 1607761 ccaaggaatc acaggaagaa aaatgttttc aacatggcgc caggtgtctc agttgatcag 1607821 ttcaaacatg atcgatcttg cacctgttat tacccatcag tttccattag aggagtttga 1607881 aaaaggtttc gaactgatga gaagcgggca gtgcggaaaa gtaattttaa ttccataaag 1607941 ggggataaac atgacgaagg aatttgagtt tttaaaagca gagcttaata gtatgaaaga 1608001 aaaccataca tggcaagaca taaaacagct tgaatctatg cagggcccat ctgtcacagt 1608061 gaatcaccaa aaagtcattc agctatcttc taataattac ctcggattca cttcacatcc 1608121 tagactcatc aacgccgcac aggaggccgt tcagcagtat ggagccggca ccggatcagt 1608181 gagaacgatt gcgggtacat ttacaatgca tcaagagctt gagaaaaagc tggcagcctt 1608241 taaaaaaacg gaggcggcac ttgtattcca atcaggcttc acaacaaacc aaggcgtact 1608301 ttcaagtatt ctatcaaaag aggacattgt catctcagat gaattgaacc atgcctctat 1608361 tattgacgga attcgactga caaaggcgga taaaaaggtg tatcagcacg tcaatatgag 1608421 tgatttagag cgggtgctga gaaagtcaat gaattatcgg atgcgtctga ttgtgacaga 1608481 cggcgtattt tccatggatg gcaacatagc tcctctgcct gatattgtag agctcgctga 1608541 gaaatatgac gcatttgtga tggtggatga cgcccatgca tccggagtac ttggcgaaaa 1608601 cggcagggga acggtgaatc acttcggtct tgacggcaga gtgcatattc aggtcggaac 1608661 attaagcaag gcaatcggag tgctcggcgg ctacgctgca ggttcaaagg tgctgatcga 1608721 ttatttgcgc cataaaggcc gtccattttt attcagcaca tctcatccgc cggcagtcac 1608781 tgcagcttgt atggaagcga ttgatgtctt gcttgaagag ccggagcata tggagcgctt 1608841 gtgggagaat actgcctatt ttaaagcaat gcttgtgaaa atgggtctga ctctcacgaa 1608901 gagtgaaacg ccgattcttc ctattttaat aggtgatgaa ggtgtggcaa agcaattttc 1608961 agatcagctc ctttctcgcg gtgtttttgc ccaaagtatc gttttcccga ctgtagcaaa 1609021 gggaaaagcc agaattcgca cgattataac agcagagcac accaaagatg aactggatca 1609081 ggcgcttgat gtcatcgaaa agacggcaaa ggagctccag ctattgtaac aagaggaaga 1609141 gtttactctt cctcttttga ttccttattg attattattc tcaatgagtg tacaatgata 1609201 ggttgccagt tgtgcagagc ttcaataacc tttatactga agggtggaag tttggtttga 1609261 aaggagaaaa tatgacatga atgaaaaaca aaaattagag agcggacaag ttcatccatc 1609321 ggacaaaaaa tccgagaagg attacagcaa gtactttgaa gctgtttaca ttccgccttc 1609381 tttaaaagac gcgaaaaaac gaggcaagga agccgttact tatcataatg actttaaaat 1609441 ttctgaacaa tttaaaggat tgggagacgg aagaaagttc tatatccgta cgtacggctg 1609501 ccaaatgaat gaacacgata cagaggttat ggcagggatc tttatggcgc tcggttacga 1609561 agcgacaaac tctgttgacg atgccaatgt cattttgtta aatacatgtg caatccgtga 1609621 aaatgctgaa aacaaggtgt ttggtgagct cgggcactta aaagcactga aaaaaaacaa 1609681 tcccgatctg attttaggcg tgtgcggctg tatgtcccaa gaggaatcag tcgtgaaccg 1609741 tattttgaaa aaacatccgt ttgtcgatat gattttcgga acgcataaca ttcatcgcct 1609801 gccggagctt ttgtcagaag catacctttc aaaagaaatg gttgtagaag tttggtctaa 1609861 ggaaggggac gttattgaaa accttccaaa agtccgaaat ggaaaaatta agggctgggt 1609921 caatatcatg tacggctgtg acaaattctg tacgtattgc attgtgcctt acacacgcgg 1609981 aaaagaaaga agccgccgcc ctgaggatat cattcaggaa gtgagaaggc tcgcaagtga 1610041 aggctataag gaaattactc tgttaggcca aaacgtaaac gcgtatggaa aagactttga 1610101 agatatgacg tacggacttg gtgatttgat ggatgaactg agaaaaatcg atatcccgag 1610161 aatccgtttt acaacgagtc atccgcgcga ctttgacgac cgcctcattg aagtgctggc 1610221 aaaaggcgga aatctgcttg atcacattca tcttccggtt caatcaggaa gctcagaagt 1610281 tctcaagctg atggcccgca aatatgacag agagcgttac atggagctgg tgcgaaaaat 1610341 taaagaagca atgccaaacg cttctttgac aacggacatt atcgtcggat ttccaaatga 1610401 aacggacgaa cagtttgaag aaacgctttc tctataccgt gaagtggagt ttgacagcgc 1610461 ctatacgttc atttactctc cgcgtgaagg cactccggct gctaagatga aagataatgt 1610521 accgatgcgt gtgaaaaaag aacgcctgca gcgtctaaac gcactggtga atgaaatttc 1610581 tgctaaaaaa atgaaggaat acgaaggcaa ggttgtcgaa gtattagttg agggtgaaag 1610641 caaaaataac cctgatattc ttgctggcta tactgaaaaa agcaagcttg tcaatttcaa 1610701 agggccgaag gaagccatcg gcaaaatcgt ccgcgtgaaa atccagcaag cgaaaacatg 1610761 gtcgcttgac ggagaaatgg taggagaagc aatcgaggtg aaatgagatg acgctctact 1610821 caaaaaaaga cattgtgcag caggctcgaa accttgcaaa aatgatttct gaaacagaag 1610881 aggttgattt tttcaaacgg gctgaagcgc aaatcaatga gaatgacaaa gtgtccacaa 1610941 tcgttaatca gattaaagcc ctgcaaaagc aggctgtcaa tctgaagcat tatgaaaagc 1611001 atgaagcgct caaacaagta gaagcaaaaa ttgacgcgct gcaagaagag cttgaagaga 1611061 ttcctgttat ccaggaattc agagactcgc aaatggaagt aaatgaccta ctgcagctcg 1611121 ttgcacacac catttccaac caagtcacaa atgaaatcat cacatcaacc ggaggcgacc 1611181 tgctgaaagg ggaaaccggt tcaaaggtga agcattcaaa taacagctgt tctctctaaa 1611241 cacggtgcct ttacaggccc gtgttttttt atcatttgtg cggttaaaaa tgaactaaat 1611301 aatctatgta ccaaatgttc aattggtttt tctgtgctca gccgcgtata aactttatcg 1611361 cacttataag taaagtttct aggcacccct gcatacaatg gaacagaaac tttgtatttt 1611421 tatattttat ttataaaaat gcacactaga caaatgccca gcataagata acacgaagaa 1611481 gaacaaggag gcatgccgga atgtctgaat acagggaaat tattacgaag gcagtagtag 1611541 cgaaaggccg aaaattcacc caatgcacca acaccatctc gcctgagaaa aaaccgagca 1611601 gcattttggg tggttggatt attaaccaca agtatgacgc tgaaaaaatt ggaaaaacgg 1611661 tagaaattga agggtattat gatataaacg tatggtactc ttacgcggac aacacaaaga 1611721 cagaggttgt cacagaacgg gtaaaatatg tagatgtcat taaactcaga tacagagaca 1611781 ataattactt agatgatgag catgaagtga ttgccaaagt gcttcagcag ccaaactgcc 1611841 ttgaagtgac catttcgccg aatggaaata aaatcgttgt gcaggcagaa agagaatttt 1611901 tggcggaagt ggtaggggaa acaaaggtag ttgttgaggt caatcctgac tgggaagagg 1611961 atgacgagga agattgggaa gatgagcttg atgaagagct tgaagacatc aacccggagt 1612021 ttttagtggg agatcctgaa gaataaaaaa gggactaggg gagacagtac ccccaagtct 1612081 cttttttata ttgatatatc attcttttat cactttttgt ttatgttata atgaaggttg 1612141 gaaaatagaa acgttgatac atagtgaggg attaaacaat ggccggttat acgcctatga 1612201 tacagcaata tttaaaaata aaggcagagc accaggatgc ctttttattt tttcgcctgg 1612261 gtgattttta tgaaatgttt tttgaggacg ccaaaaaagc gtcacaagag ctggaaatta 1612321 cgttaacgag cagagacggc ggtgcggctg aaaaaatacc gatgtgcggt gtgccgtatc 1612381 attctgcttc cgcgtatatc gaacagctta ttaaaaaagg atacaaagtg gcgatctgtg 1612441 aacagacgga agatccgaaa gccgcaaagg gcgttgtgaa aagagaagta gttcagctga 1612501 ttacgcccgg aactgtaatg gacggcaaag gcatccatga gtcggaaaat aattttatcg 1612561 catctgtttc agcctgctcg aacggatacg gacttgctct gtctgattta acaacgggag 1612621 aaaatttggc tgttttgatt gaacggcttg aagacgtcat atcagaaatt tattcagtcg 1612681 gcgcacggga aatcgtggtt tcaggaagct tggatgccga tacagtggca cagctgagag 1612741 agcggtgcgg tgcaacgatt tcaattgaag acggagaaac agacgaacac gtaacgatca 1612801 ttgagcactt aaataatgaa gatataacaa aaacatttct gcgcttatat acgtatttga 1612861 aaagaaccca aaagcgcagc cttgatcatc ttcagcccgt gcaggtgtat gagcttgagg 1612921 aagcgatgaa aattgacttg tactcaaagc gtaatctgga gctgaccgaa acgattcgtt 1612981 cgaaaaataa aaaaggctcc cttttgtggc tgctggatga aacaaaaacg gcaatgggag 1613041 gccggctact taaacagtgg attgaccggc cgcttatcag agtcaatcaa atcgaagagc 1613101 gccaagaaat ggtggaaaca ttaatgtccc atttctttga acgggaagat ctgcgtgaac 1613161 gtttaaaaga agtatatgac ttagaacgcc ttgccggccg cgttgcattc ggaaatgtca 1613221 atgcccggga tttgattcag ctgaaggaat cgttaaagca agtgcctggc atcaaacagc 1613281 tggttgcttc actggctcat gacaaggcca aggaacgtgc aaagcgcatt gacccttgcg 1613341 gggatgtact tgaactgctg gaagaagcgc tgtacgaaaa ccctccttta tcggtaaaag 1613401 aagggaacct gattaaagat ggttataatc aaaagcttga tgaatatcgt gatgcaagca 1613461 gaaacggaaa agactggatt gcccgcctgg aacagcagga gcgggaatac acaggcattc 1613521 gctctttaaa ggtcggcttt aataaagttt tcggttatta cattgaagtg acaaaagcaa 1613581 acttgcattt gcttgaggaa gggcgttatg agcggaagca gacgttaacc aatgcagagc 1613641 gctacattac acctgaatta aaagaaaaag aagcgctcat tttagaggcg gaaaataaca 1613701 tctgtgagct ggagtacgag ctgtttaccg agctgcgcga gaaagtgaag cagtatattc 1613761 cgcggctgca gcagcttgca aaacagatga gcgagctgga cgcactgcaa tgctttgcga 1613821 caatcagtga aaatcgccac tacacgaaac cagagttctc taaagatgaa gtcgaagtga 1613881 ttgaaggcag acacccggtt gttgaaaaag tcatggacag ccaggaatat gtcccgaaca 1613941 actgtatgat gggcgataac agacaaatgc ttctcattac aggtccaaac atgtcaggga 1614001 aaagcacgta tatgagacaa atcgcgctca tttccattat ggcgcaaatc ggctgctttg 1614061 tacccgcgaa aaaagcggtg ctcccgattt tcgatcaaat ttttacgcga atcggcgctg 1614121 cagatgattt gatttccgga caaagtacat ttatggtaga aatgcttgaa gcgaaaaatg 1614181 cgattgtcaa tgcgacgaaa aacagcctca ttctgtttga tgaaatcggg cggggaacgt 1614241 ccacttatga cggcatggcg ctggcacagg cgattattga atatgttcac gatcatatcg 1614301 gcgccaagac gctgttcagc acacactatc acgagctgac cgttcttgag gacaagctgc 1614361 cccagctgaa aaacgttcat gttcgcgctg aagaatataa cggaacggtt gtctttcttc 1614421 atcaaattaa agaaggtgcg gctgataaaa gctatggtat ccatgtagct cagcttgccg 1614481 aactgccggg agatctgatt gcgcgcgctc aagatatttt aaaagagctt gagcattcag 1614541 gaaacaaacc ggaagtgccg gtgcagaaac ctcaggtgaa agaagagccg gcacagctgt 1614601 ccttttttga cgaagcggaa aagccggctg aaacaccaaa gctttcaaaa aaagaaaagc 1614661 aagtgatcga tgctttcaaa tcacttaata tactggatat gacaccgctt gaagcgatga 1614721 atgaaatgta caagctgcaa aagaaattac attaaaacgg ggtgatgaat gtggcaaaag 1614781 tcatccaact gtcagatgag ctttcaaata aaatagcggc gggcgaggtt gtggaacggc 1614841 ccgcctcagt cgtcaaagaa ttggtggaaa atgcgatcga cgctgacagc acagtcattg 1614901 aaatcgatat tgaggaagca ggccttgcat ccattcgggt cttggataac ggcgaaggaa 1614961 tggagaatga agattgcaag cgagctttcc ggcgccacgc aacgagtaaa ataaaagatg 1615021 aaaatgattt attcagggtg agaacgctcg gtttcagggg agaagccctg ccgagtatcg 1615081 cgtcagtctc tcatctggag attacaacaa gcactggtga aggagctggg acgaagctcg 1615141 tcctccaagg aggaaacatc atttccgaat cgcgttcctc aagcaggaag ggaactgaaa 1615201 ttgtcgtttc caacctgttt tttaacacac cggcccgttt gaaatatatg aaaaccgttc 1615261 atacagagct tggaaacatt acagatgtgg ttaaccgtat tgctctggcg catccagagg 1615321 tatcgatccg cctgcgccat catgggaaaa acctgcttca aacgaacgga aacggagatg 1615381 tgcgccatgt actggcagcg atttacggca cggctgtcgc caaaaaaatg cttccgctgc 1615441 atgtgagctc cttggatttt gaagtaaagg gatatatcgc cctcccagag attacacggg 1615501 cgtcgagaaa ctatatgtcg tctgtggtca atggccgtta cattaaaaat ttcccgctcg 1615561 tcaaagcggt tcatgaaggc tatcatacgc ttctgccgat cggacgccat ccgattactt 1615621 ttatagaaat tacgatggac ccgattttag tcgatgtcaa cgtgcatcca tcgaagcttg 1615681 aggtccggct cagcaaggaa acagagcttc atgacttaat acgtgacgga attaaagatg 1615741 tgtttaaaca gcagcagctg attcctagtg cccaggtccc gaaaaaatca gcacctgcca 1615801 tcaaaaatga gcagcagttt ataacctttg atgaaaagcc tccggaaaaa aaagttccgg 1615861 aaaaatcgac tgcgccatct tattcaccga tgaagctcag ctcagtcgta aaagagccgg 1615921 ttgatgcgga ggaaaaattg ccccctctcc aatttgatgc tcctcctatc gttgatcagg 1615981 aacaaaccct tgaggtgtcc gatgtttcag cagaacagcc tgaaacattt gagcaggaat 1616041 gccatgagga acagccgcag ccagcgtctg atcgggttcc aattatgtac ccgattggcc 1616101 agatgcacgg gacttatata ttggcacaaa acgaaaacgg cctatatatt atcgaccagc 1616161 acgccgccca agaacgtatt aaatatgagt acttccgtga aaaggtgggg gaggttgagc 1616221 ctgaggtgca ggagatgatt gtaccgctga cgttccacta ctccacaaat gaggctttga 1616281 ttattgaaca gcacaaacaa gagctcgaaa gcgtcggtgt ctttttagag tcattcggct 1616341 ctaacagtta catcgtccgc tgccacccag cctggtttcc aaagggagaa gaagcagagc 1616401 ttatagaaga aatcattcag caggtgctcg actccaaaaa tatagatatt aaaaaacttc 1616461 gcgaggaagc ggcgattatg atgagctgca aaggctccat caaagcaaat cgccacctca 1616521 gaaacgacga aatcaaagcg cttctggacg acctccgaag cacatcagac ccatttacat 1616581 gcccgcacgg ccgcccgatc atcattcacc actcgacata tgagatggaa aagatgttca 1616641 aacgcgtgat gtagcggggg tggtaggcat tgatccattc tctgaatgga tcaatgcttt 1616701 ttttgtactc cttcgagtgt cagattataa gaaacggttg taaacgtgtg agcagtgtta 1616761 acgcattata cttcatggtt cctccgtata acaaaatttc catttacagg caattgggat 1616821 taatgtatat tttgggtgag ggggtggaaa catatggcat gtggtccgaa gatcattatc 1616881 tttttggatg aacttgatga tccaaatgtg agaatcattt tagaatgcag aatttaaatt 1616941 acaacattgt gttttgctcc ctgttcgtgt gaacagggag attttttcgt ttatataact 1617001 ggtgatgtcc aaatataggg tgttatgaat tttccatatc tgccatcggc tttaagctgc 1617061 ttctctatta ggctggttat caaaagcaag ttcaatgata gccatgaaag ctgatatcac 1617121 aacaagcaag acatctggaa tataaataga ctgcataaag taatctgcaa aacagatcgt 1617181 tataagattg ctgataaaat acagtataaa agcaaaaagt gcagtctttt tcaatgaaag 1617241 tgattttgcc aaaatgatag agataatctt tgtgagtggg tctatgatta aacctacagc 1617301 aaagcaggct aaaataaata aagctaatgt ttgattggaa gcgtatgtga tgccaagtat 1617361 ggagaataag cctttcatcc cgaagaaaaa gccgccgaag atgactgcaa gcgcgatggc 1617421 cgcgataaaa gtaatagata caattccgat taattttgat ctcaggttaa aatctttaga 1617481 gtgctcgttc tgttcttttt ggttcatgta tgacactccc ttcacctgct tactcataca 1617541 aacagcaccc ttgaatcagc ccaaaatatc tataagtctg ttttctgacg aaaatagtat 1617601 agcatatttt aacaaaacca aaaaaggccc tttccactgg ggaagggcct ttttcatcat 1617661 gttaactcct gagattcgcc gaagctttct ctttttttgg ccaaataaaa tagctggctg 1617721 taatgagaaa gtcaatgcct ataatgacag tccacagttt aagaatgccg ctcaacgcct 1617781 cggttcggga agagtcattg ataaaataga tcatccctgc caatagtccc gcaccaatta 1617841 agtaggccag cacatgtctt agccagcctt tcgcaccgtg cttggcatgg tccattccaa 1617901 aacgtttcag cggttttgtt cctttttttg tcacataata ttgaaacttt tcatctgccc 1617961 attgaatcat ttgtttccca taagcgatcg atataccgat gtaaacagct gcaatcccat 1618021 gggctgcggt cgctgaggct ccgcggtaaa ggtccacacc agttgccgct aacaagatca 1618081 aatcgataac tggagttaag gcaaggaata gcagtcctaa tgtatgtcgt ttgaatacgt 1618141 agcgtacagc aagccccaaa acaatgacaa cccaaaacgc aatttcacag aaaacaatca 1618201 tccatgcgat accgttcaat ccattcccct cttttcaata cagttgtatt atttaaataa 1618261 tatgttacca tctttgtttt tgtaacacaa ctgtattata aaaattgccc cgcctttgaa 1618321 cgaaagctca aaggcgctac gctgtattat tttgatgaaa gtggctgtca gctgtgctgg 1618381 atatcaattg tatatactgc acgatctgtt acgaccttca atccttcgtt ttcttggtga 1618441 atatgaagct cacctaataa aggaatctca taggcatttt gcggaagcgg tacgtttccg 1618501 tcctcagtga atgttgttcc ttcgccttct aaaacaagct cttctttcgc aacataatca 1618561 tcaggatgat tcgtactgcg tatagccact ttttgaaggt ggagaacaat ctgatccaag 1618621 tctgatatct cttcatcatg ggtcaattca ccttttctaa tatcaagcgt ctggccgact 1618681 tttgattcca gccattgaga aagctgtgta ttcgtgtgtg ccatcaatat tcctcctttt 1618741 gatctacacg atactattcc caattgctgc atcttttaca cgggaaagag ccgccccact 1618801 ctttatgtat gaaacagttc gctgttgagt gccttgatat agcgtacggc agaacgctgg 1618861 accgattcgt cggcattttc tttgacaact ttagagaaag cattgtaaag ccggttgaat 1618921 tgaagcggtt ttactttggc tgctatttct tcaactttgg aggcgggaag gggaatgaga 1618981 tttgggtagc tgtacataaa gctgacccag tttcgatccg ccgcaaccgt aatgatatct 1619041 ccggtcaata gacagccttt cccttcattg cccttgctcc aatgcaaaac agcaccgcct 1619101 ttaaaatgtc cgcccagtcg gtaaaggtcc agtcccggct tcatattgag cgtttcccct 1619161 gaccagaagt gaatgtgatt gcttggcctt gtcacccatt ctttatcatc ctcatggata 1619221 tagatcggcg cctgaaacgc ttcagcccac tcaacctgag tagagtaata atgtggatga 1619281 gacaaggcga tggcttgaat accgcctaat tcgttgattt ggtcaattgt cttttggtca 1619341 agatatgtca tgcaatccca cagcacattg aagcccttat gctgaataag atgggctgtt 1619401 tgtccaatcg caaactctgg ttcagttttg atgctgtaaa gatgctcttc ttccttttta 1619461 aggatgtttt gaaggtttcc tttctcacgc atgtcttcaa gggttgtcca agtttgtcca 1619521 tcgggatgaa tatactgtct ttcatcctcg caaatcagac acgagttggg cggatctaca 1619581 gtctgtgcat gttgcacacc gcatgtattg cagatataat atggcacttt cttcacttcc 1619641 ttcatctatt ttccattatt ttaccttatg attatgaata ttcaaacgaa aaaaccggca 1619701 gttctgctga gagagaattg ccggcttttg atgatgttta ttggccggga acggaatttt 1619761 ctgcgttgac agcgcccgct ccgtagatat tcggatcttc atctttccat ttgtccgtgc 1619821 cgtttttcaa aagctctttt acttcatcag gggtaagatc cgggttttgc tgaagaatta 1619881 aagctgcgat tcctgcgcaa atcggtgttg ccatcgaggt tcctgacatt gtaaagtact 1619941 gagaccctac acggcttgac ttttggagct tatcaatata agaattcgga gagcgaaggg 1620001 aaataatatt aacacccggc gctaaaatat cgggcttttc tttcccgtat actgtcgggc 1620061 cgcggcttga gaaggaagcg acagtatcat catcgctgct tgcagtattg ttatcgtcaa 1620121 gcgcacctac tgtaatcacc ttttcgctca cgcccgggct tgcaatggtc tgcgaatcag 1620181 ggcctgagtt tccggcagcg acacagacga caatccctgc gctccacgct tcctcaaccg 1620241 ctctgactaa cggatcttcc tgttcatgat catatctaag ggcatcgccc ccgagcgaca 1620301 tgctcataat atcaatcggt tcatcggggt tgtcctcatt gtattgaata caccactcaa 1620361 caccctctat aatatctgct aacgttcctg aaccctgctt gtttaatacc tttacgccga 1620421 tgagattggc ttccggtgca ggtccgcggt attgaccgga agaggatgca ccgctgcttg 1620481 cgacatcacc tgcacagtgt gtgccatgac cattatcatc gtacggctct gttttttgat 1620541 tgaccatgtc cgcgaatccg ataattcttc cttctagatc aggatgcggg tagattcctg 1620601 tatcgacaac agcgacagta acaccttttc ctgtcagggt ttgcccgttt ctgacgactt 1620661 ccttcgcatg gcttgcttcg gttgccgtgt ctaaaagcgc tttgacttcg cggtttaaat 1620721 acactttacg gatattgctg cattcagaga gaagggaatg taatgctgaa ggagtaacct 1620781 cggcgctgca gcagttgatt ttgttgaagc ggctttttag cttgctgcgt ttttcttttt 1620841 gcagcacctc tccagccatt tgaaagccgg tctcgtgaca gccttcctca aattcgataa 1620901 tgactgacat tttttttctg ttttgcaatt tggtttcgaa aaatttatgc aagaagcaag 1620961 gagtccattt gaagggcttg taaagttgca atacggtttc ccgtaacggc caatctagct 1621021 tgtgagcatt tgctctcacc atttgtacca tagagtaccc aaacatgtat tttcctccta 1621081 ttataaggtt ctctgtatac tctatgaaca gatgataggt ttggtaagtt tgtttgtcct 1621141 ctgtaagaga cagacaagag tttgtttttc tgaatctttc gcattagata cgatagattc 1621201 agaagctgag gaaatcattg gggattgaaa aagaacgttt gttcgtatta taatgtgatc 1621261 atatcaaact gggaagggga gagcaaccgt atgaatttct acttgcaccg atctttggaa 1621321 agccaaatgc caatcagcat tatatatgaa gaaagacgga acgattagta aaagaacgat 1621381 tattgtgaga cagaaaagca aaacgaaaat caaagcattt tgtttttcga aacaacagat 1621441 cagaacattt ttattggact ctatcctctc ctgtgatttt gtgagaacaa ataagcaaaa 1621501 tctctattct gcaggccggt aacagctgtc cgtctcagca accgggcagc ctgttactaa 1621561 aaccctcctt aaacctatat acatttattt gccaagtgag gttgttccta ccttttttgt 1621621 ctttcctctc aacctttttt cactcttatt tgaaatgaac cgctaataac cgtgacaatc 1621681 aattgatttt ttgaaaccgg gaactttttc actgatgata ttgtgtatac aatggtaaga 1621741 taaaacctat tggctaaacc tcatataatg aaccgcgcca ttcttatgaa aggagttaaa 1621801 catgagaaga tttttactaa atgtcatatt agtcttagcc attgtcttgt tcttgagata 1621861 tgttcattac tcattggaac cagaaccatc aaatcagcca gatacatatt caaatttcag 1621921 cagcttggca gagaatgaga gcccagccga ttacgatatt tcatataatg agaaaaaagg 1621981 aagcaaagtc ttaattatgt ctccgcatgg cggaagaatt gaaggcggag taagtgagct 1622041 tgtgcgttat ttcaataatg aatactctac atacctattt gaagggttga agtcccatga 1622101 taaccaaaca ctgcacatta caagcaccaa ctttgatgag ccattggcaa aaaagaaaat 1622161 caaggagcat caatatgtgg tggcttttca cggatataaa ggagagaaca agaataccct 1622221 tgtaggggga acagaccgaa agcgggcgaa aatgattgtg agagcccttg agcggagagg 1622281 gttttccgct gagttagcgt cgtctaaaag cggtcttgct ggattgaatg ccgaaaacat 1622341 taataaccaa ggggaaacgg ggctaagtat ccagctggaa atcagccgtg agcagagaga 1622401 agcatttttt gatgattttt attataaaaa tagaaaatac acaaagaaca gtgaatttta 1622461 tgcttatgtc agtgcgatca aaggtgtcct ggaaaaagag tattcgtaac aagcagatca 1622521 gaagacaaaa taagagaaga tcagtagact gaaataggat aaaaaaggag gcaaaacaat 1622581 ggcagatcat catttttatt taaaagcgaa ctggccgggt aaccgtaatg atgtcggtac 1622641 gatcgaaagc ggaaacctga tcacatcgat ttccattcct aaagaaatgg atggcccggg 1622701 agaagggacc aacccagatg aaatgcttct cggggcggca gcgacctgtt acattattac 1622761 acttgcagcg atgatggaga gaagcgggct ggaaaaagaa gacttacaga tggagtcaga 1622821 aggcattgtc aacgttacaa aaggagtctt tacatacaaa aagatcattc accgtccctc 1622881 tgtcgtgctt aaacatgatg cttcacaaga cgacgtcgca ttggcgcaca aactttgtaa 1622941 aaaagcggag tcgtcatgca tgatttcgcg tgcaattcaa ggaaatgtcg agctgcagct 1623001 tgaagcctct gtgaaactgg gtggagaata aagaaaacag acggtcactc acaggccgtc 1623061 tgttttttat cttcagcgtg ggctttcgat tgatttagca cgaccacgcc tgcaatgaca 1623121 agcgtgagac cgaatacacc ttttaaactg atggtttcgc caaaaagcaa aaacccgaca 1623181 attgctgtaa gcgcggtacc aacgcccgac catgttgcat acgcgcttga taagtcaatt 1623241 gtttttaaag aaaagcttag aaacgtaaaa gcagaaagaa atccgactat gactccggca 1623301 atgggccagg cttgtgtaaa tccttctgaa agcttcaaca tcgtgctccc aaacacttca 1623361 gatacaatgg cgagagccaa ataaagcaat cctctcatct tcatcactcc tttacggcca 1623421 attaagtaac acgacccctg atagtaataa aagaatcccg ataagccctt tggcattcag 1623481 atcttccttg aaccatttta ctccgatcac tgtcgtcagc accgtgcctg ccccgctcca 1623541 agtcgcatag gagaggctca ggggaatatg gtttaaagtc agggacagca tataaaaggc 1623601 gagggaatag ccaataacga ccaaagcact tggcttccac tttttgaagc catcagatac 1623661 tttcagcatg gctgctccta tcgattccga acatatggca atcgtgagga atatatatcc 1623721 tatcaacatc atgaattctc ctcactatat ttttagatta gaaaaaaaac ttcagctaga 1623781 aaaatattag tgtatgccta tgtatgagtc aagagattca ttttcacaca cttaaaaaga 1623841 ccccttttta aggggtcttt tgcgtttaat aataaaaagg gaacggggca tacggataat 1623901 aggggtatcc gccatacaaa taaggattaa ataaagcgct tcctataagc ccgcctgcaa 1623961 ggccgccgat aaacggtcct ccaaaaaatc cgaatggccg gccaaaccca taaccaaatc 1624021 cgggtcttcc aaacccgtaa ccgaacccga acggtcttcc aaacccaaat ggtctcccga 1624081 atccgaacgg ccttccaaat attcttgtat cttcagggct gaaatgctct aactcgttca 1624141 tgttttcttt cctcctgtaa taaagtgtag atgatgcagt gtattcaccc tgcccggatt 1624201 tgattgggcg aatcgaggaa aaggaggatg tgaacacatt gggcctgtat cagtctgact 1624261 ggtcaaaagc accgccccac gcacatgctt atcatgtcaa aacaacgaga gaacagggcc 1624321 attatcatct catcgaaggg tttactcagc cggcaaacgg atcaaatacc gatcagcata 1624381 cacattacta tacagggatc acttcatttg aaaacggcca ttttcatcgg tattacggaa 1624441 tctcaggacc ggcgattccc ttagcagatg gcacacatta tcatgaaatc gaagaaacga 1624501 cgtatctggc ctataacgag ccgattgaga tccagtacgg aggggttgtg tacgatcccg 1624561 gagatgacag aagaaaaacg catcgtcata ccctgaaagg aaagacaagg gaaattgtcg 1624621 gcaatgagcc gctcggctgg tagaaggatg tttaccgatg caaaaaaagg gcaaaatgga 1624681 taggtggttg tccatgttga atgctataat ggggggagat ttataaaaga gagtgataca 1624741 tattgaataa tacgaagcag cccgttgtca ttttagtcgg accgacggca gtggggaaaa 1624801 ccaatttaag tattcagcta gccaaatcct taaacgcgga aattatcagc ggagattcga 1624861 tgcagattta taaagggatg gatattggaa cagctaaaat taccgaacag gagatggagg 1624921 gagtgcccca tcatctgatt gacattttag atccccaaga ctctttctct actgccgatt 1624981 atcaaagctt agtaagaaat aaaatcagcg agattgcaaa tagaggaaag cttccgatga 1625041 ttgtcggcgg tacagggctt tatatacaat ctgtgcttta cgattataca tttacggaag 1625101 aggcaaatga tcccgtgttt cgagagagca tgcaaatggc tgctgagcgg gaaggcgctg 1625161 actttcttca tgccaaactt gctgcagcag atcccgaggc agcagctgcg attcatccga 1625221 ataatacaag aagagtcatt cgcgcactgg aaattttaca tacgtccgga aaaacgatgt 1625281 cccagcattt gaaggaacaa aaacgagaac ttctgtacaa tgcagtgtta attggcctga 1625341 caatggatag agacacgctt tacgaaagaa ttaatcagcg ggtcgatttg atgatgcagt 1625401 caggccttct tccggaagtg aaacgcttat acgacaagaa cgtgagagac tgtcaatcaa 1625461 tacaggcgat aggctataaa gagctgtatg catattttga cggttttgtg acactttccg 1625521 atgctgtcga acagctaaag cagaactcga ggcggtatgc gaaacgccag ctgacgtggt 1625581 ttcgcaacaa aatgcaggtc acatggttcg atatgacacc gcctgttgat atggagctga 1625641 aaaaaaagga aattttcaca catatagcag gaaaactcga actttaatcg aaactgtatg 1625701 atatagagaa tcaaggagga cgaaacatga aaccgattaa tattcaggat cagtttttga 1625761 atcaaatccg gaaagaaaat acgtatgtca ctgttttttt gctgaacggc tttcagttgc 1625821 ggggccaggt gaaaggcttt gataacttta ccgtattgtt ggaatcggaa ggtaagcagc 1625881 agcttatata taaacatgcg atctcaacgt ttgcgccgca aaaaaacgtc cagcttgaac 1625941 tcgaatagat caaaaaatgc catgtcaaga catgaggaaa ggctgtcggg ggttcccggc 1626001 ggccattttt aacatgaatc cacttttgct ccaagctttt tgtgtaagct gaccatgcca 1626061 aggcacggtc tttttttatg agaacaacat acggaagtaa aaatggtata ttatgtataa 1626121 aatgaatttg ggagtgatcg atcttgtttg aaagtgaagc agaactgaga cgaatcagga 1626181 ttgcacttgt atggatagct gtctttttac tgttcggggc gtgcgggaat caagatacca 1626241 ttattgaaac agacaacggc aattcagact atgaaacgcc tcagcccacc tcgtttccac 1626301 ttgaacataa ccattttggc gttatggagg acggctatat caaaatttat gagtataatg 1626361 agtcccgcaa tgaggtaaag ctgaagaaag aatacgcgga tgatgagctt gaataaaatt 1626421 cacaagcatt cgaatttaca aagcggatgc cagccgctaa actaaataca gacacagatc 1626481 aaacagaggg tgaaaacatg aagcataaag tgatcgtgaa tcattgggaa gaaatttgcg 1626541 aagatgattc ttgctatgaa tacggaacaa gtatcattgt gaacggaaaa gaattaatca 1626601 gagaagcgtc aattatcact gctttgaagg cggttttaga agagatcggc gcggatgttg 1626661 aaatagaaga aacagtagag agcgaaaaat gctgtgatag cttaagaaaa aaaaatctag 1626721 actactaagc agtttttttt catgttatga tatacatcgg ctaaaaacga caccccgagt 1626781 aggacgagag atgattctcg ttctgctctc ttttttgggc cctaatgagt ctgcccgttt 1626841 gcctgatttg atcaaaatat gaatttttca taaaaacgaa tctatatatt gtgtttttgc 1626901 tagagggtag tatactatat atagtgttag tgatgagaga ttcatatttt ttgataggtc 1626961 gtgataaaac gtggtacaaa tcatatttga ttcgaaaaca gggaatgttc agcggtttgt 1627021 gaataaaaca ggctttcagc agatacgcaa ggtggacgaa atggaccacg tggacactcc 1627081 gtttgttttg gtcacctaca cgacaaactt cggccaggta ccggcatcaa cacaatcatt 1627141 tctcgaaaaa tacgcccatc tcttattggg agtcgctgcg agcggcaaca aagtatgggg 1627201 cgataacttt gcaaaaagcg ccgataccat ttcaagacaa tatcaggtgc cgatcttgca 1627261 caaatttgaa ctcagcggca catctaaaga cgttgaattg tttactcagg aggtagaaag 1627321 agttgtcaca aaatcaagtg ccaaaatgga tccagttaaa taacgaaatc atgatccaaa 1627381 aagatgggaa attccagttt gataaggata aagaagctgt acatagctat tttgtagatt 1627441 atatcaatca aaacacagtc ttctttcaca atttaaaaga gaagctggat tatttggttg 1627501 aaaaccaata ctacgaagag gaattcttaa gcctttattc ttttgaagac attaaagaag 1627561 tgtttaagac agcttacgct aagaagtttc gttttccttc cttcatgagt gcgtttaaat 1627621 tctataatga ctatgctttg aaaacgaatg acaagaaaaa aatcctcgag cgttatgagg 1627681 accggatctc aattgttgcg ctgttcttcg ctaacggcga cactgagaaa gcaaaagaat 1627741 atgtaaacct gatgatcaat caagaatatc agccgagcac accgacattt ttgaatgccg 1627801 gcagaaaacg ccgcggtgaa cttgtgagct gcttcttgct cgaagttaat gattctttaa 1627861 atgacatttc aagagcaatc gatatctcca tgcagctttc taagcttggt ggcggggttt 1627921 ctcttaacct gtccaagctt cgcgcgaaag gtgaagccat taaagatgtt gagaatgcga 1627981 caaaaggcgt tgtaggcgtc atgaagcttc ttgataacgc gttccgttac gctgaccaaa 1628041 tgggacaaag acaaggctcc ggcgcggcgt atttaaacat tttccaccgc gatatcaatg 1628101 attttcttga tacgaaaaag atttctgcgg atgaagatgt gcgtgtcaaa acgctttcga 1628161 tcggtgttgt cattccggat aagttcgttg agcttgcacg cgaggacaaa gcggcttatg 1628221 tattctaccc gcacacgatt tataaagagt acggccagca catggatgag atggacatga 1628281 acgaaatgta cgacaagttt gtcgacaacc ctcgggtgaa aaaggaaaaa atcaacccgc 1628341 ggaaactgct tgaaaaattg gcgatgcttc gttctgaatc aggctatcca tacatcatgt 1628401 tccaagataa cgtcaataaa gtgcatgcga ataaccatat ttccaaggtc aaattttcta 1628461 acctttgctc tgaagtgctg caggcatctc aagtttcttc atacacagac tatgatgaag 1628521 aagatgaaat cggtctggat atttcctgca acctgggttc gcttaacatt ctcaatgtca 1628581 tggagcataa atcaatcgaa aagacagtca agcttgcgac agactcttta acacacgtgt 1628641 ctgaaacaac agacatccgt aatgcgcctg ctgtaagacg ggcaaacaaa gcgatgaaat 1628701 caatcggcct cggtgctatg aaccttcacg gctaccttgc gcaaaacggc attgcgtatg 1628761 aaagtccgga agcgcgtgac tttgcaaaca cgttctttat gatggtgaat ttctactcca 1628821 tccagcgttc tgcggaaatc gcaaaagaga agggcgaaac gtttgatcaa tatgaaggat 1628881 caacctatgc gacaggtgaa tacttcgaca aatacgtttc aactgatttc tcaccgaaat 1628941 acgaaaaaat cgctaatctg tttgaaggta tgcatatccc gacgacagag gactggaaaa 1629001 agctaaaagc atttgtcgct gaacacggta tgtatcacag ctacagatta tgcattgcgc 1629061 cgacaggctc tatctcatac gttcaatcaa gcacggcgtc tgttatgccg attatggaac 1629121 ggattgaaga acgaacatac ggcaactcaa aaacgtacta cccaatgcct gggcttgcat 1629181 ctaataactg gttcttctat aaagaagcct acgatatgga catgttcaag gttgtggata 1629241 tgatcgccac tatccagcag cacattgatc agggaatcag ctttacattg ttcttaaaag 1629301 acacaatgac gacccgagat ttaaaccgaa tcgatctgta tgcacatcat agaggaatta 1629361 aaaccattta ctatgcaaga acgaaagata ctgggcaaga cagctgcctt tcttgtgttg 1629421 tttgattaaa ggagagttta tagtgacaaa aatttatgac gcagcaaact ggtcaaagca 1629481 tgaagacgat tttacccaaa tgttctataa ccaaaacgtg aaacagttct ggcttccgga 1629541 agagattgct ttaaacggcg atctcctcac atggaagtac ctcggaaaaa atgagcagga 1629601 cacttatatg aaggtactgg ccggacttac gcttcttgac acagagcagg ggaatacggg 1629661 gatgccgatc gtggctgaac acgtagatgg ccaccagcgg aaagcggtgc tgaactttat 1629721 ggcgatgatg gagaacgctg tccatgcgaa gtcgtactct aatattttca tgacccttgc 1629781 accgactgaa acgatcaatg aagtatttga atgggttaaa caaaataaat atttgcagaa 1629841 aaaagcgcaa atgattgtcg ggctttacaa agccattcaa aaagatgatg aaatttcact 1629901 gttcaaagcc atggttgctt ccgtctatct ggaaagcttc cttttctaca gcggtttcta 1629961 ttatccgtta tatttctacg gacaaggaaa actgatgcaa agcggtgaga tcattaacct 1630021 gatccttcgt gacgaagcga ttcacggcgt gtatgtcggt ctccttgctc aggaaattta 1630081 taataaacag acagaagaga aaaaagcaga gcttcgtgaa tttgcgatcg acctcctgaa 1630141 tcagttatat gaaaatgagc ttgagtatac agaggacttg tacgatcaag tcgggctctc 1630201 acatgatgta aagaaattca tccgctataa tgcgaataaa gcgctgatga accttggatt 1630261 tgatccatac ttcgaagagg aagacattaa tccgatcgtt ttaaacggat taaacacaaa 1630321 aacaaaatcg catgacttct tctctatgaa ggggaatggc tataaaaaag cgacagttga 1630381 gccgctcaaa gatgatgact tttattttga agatgaaaaa gagcagatat aatatctgct 1630441 cttttcggct tgaaggttca aatgaggagg acgcagtacc catgggaaaa atggacgaaa 1630501 tgattttagt tgccccgcgc gatgatgtgt ttaaaaaaga aagcttaacc ttccagggcg 1630561 tgtacagtga agatagcaga gtagcagaaa tcatggctca gattgaagcg gcctatcgtg 1630621 aaatgagaag aggggacgca gaagaagatc cgcgtttcaa gcagccgata ccttatgtcg 1630681 tcattaagcg tgaagatgaa gtttttcttt acgagcggct ggctggcggc ggtgaatcac 1630741 gtctgcacaa caagctttct ctcggttttg gcggccatat gaacgccatc gaaggggcag 1630801 cttcatttgc tgaagtctta aagctgaaca cagaccgtga gcttgaggaa gaactgcaaa 1630861 taaatgaaga agataaacag gcgattgtca cactgggatt gatcaatgat gatgaaaaca 1630921 gtgttggcaa agtgcatatc ggtattcttt ctgcgcttca attaaagcct ggcgcacaag 1630981 tggaagtgaa ggagaaagaa caaattgcgg gtaaatggat gaaagtttct gaattaaaac 1631041 aggatgatat ctacaaccgt ctggaaacat ggtcacagtt tgttgttgat attcttgaat 1631101 aaaaaaaccc ggtttctcgc gatgaggagc cgggtttttt tatgagacgc tcgtccccgt 1631161 ctcggctatg attctaggat cacaatagcg tcaaagccgg catttttcgc tctggcagcg 1631221 agggtgtctg cattgtcttt ggatgaaaat gcgccaatct gcactttgta taatccgtcc 1631281 tttaaaagga caatcgagtc aaaacctttg gcttcggcat tacttgcgag cgagtcggca 1631341 ttcgctttga ctttaaatgc gccgatttga accttatata accctgagct ggaagtcttt 1631401 ttaaggttaa aggcttgctc cagcccgttt gcatgtcctc tcgctaagct ttgaataaaa 1631461 ctgctcgttt tcagcttatt tgcatcggaa acggtatcaa tgaagccgtt ctcggtcaag 1631521 agggcaggca ttgccgactc ccttaggacg tggaagttcg ctgttttttt gccgcgatcg 1631581 gcaaagtcga cagcttgtat cacttcagag tgaattgtcg attgataagt cgtcgtcggg 1631641 gctcctacat ctggataaat atagctttca aaacctgtgc ctcccccgga attaacgtga 1631701 atggacaaaa agaaatctgc tccccagtta tttgcggcat ttgtccggtc gtttaagctg 1631761 acatattggt cgcttgtccg gctcagcagc agagaaacgc cttcatattc attagttaat 1631821 atcgtacgta aggctaaagc gatttgcagg gttaacgttt tctcctgaag gccattacct 1631881 gttgcgcctg gatcagaccc gccatggcca ggatcaataa aaattttaac catttttcat 1631941 cacctcatta caggatatga aaaaacacgg cttctgcttg tacgattatc attcaactga 1632001 aaaatgagga aataaccctt tcacatccag aaattatttc tcgggaaagc gcacaattca 1632061 acatgaagcg acaacagata cggtccgaca tgaaatctgt gcatacgcca tatgtttgta 1632121 tgtactatgg gttcggttaa cctgcactga ttcctgctgg ttttaagctt tgcgttcata 1632181 ttaaatcaag catttaaaac gtaaattgat gaggaaagct cctttcatta aagacaccgc 1632241 tttataaatc gaaaaaaaga aaaacacttc aggtatctta gggcgggtaa tacgtttcgt 1632301 acaaaaatca gcccgttgta tgaaaaagaa ataatgagaa agaagctcac tataatactc 1632361 tgacaaaatg attaaaaaca aaatctcatg gtttgtccac cccatgtccg tgaatacaat 1632421 aagaaataaa gtatttctcg ggaaagcgca ggattcctta ttgttcccga aaaaagcaat 1632481 tgtttcgaca catgataggc gtttgtcaca atcggcatcc gcttgaatat catatagaga 1632541 gaacagagag gtgaagatgt tggagcgcgc tgtgacttat aaaaacaacg gacagatcaa 1632601 cattattctg aacgggcaaa agcaggtgct gacgaatgct gaggcagagg cggaatatca 1632661 ggctgcattg caaaaaaacg aagcaaagca cggcattttg aaggaaatcg aaaaagagat 1632721 gagcgcatta gttgggatgg aggaaatgaa acgcaacatc aaggaaatat acgcctggat 1632781 ttttgtgaac caaaaacgcg cggagcaagg cttgaaggtt ggaaagcaag cgctgcacat 1632841 gatgtttaaa ggaaatccgg gaacgggaaa aacgacggtt gcacggctca tcggcaagct 1632901 gttctttgaa atgaatgtcc tgtcaaaagg ccacttaata gaagcggagc gggctgacct 1632961 ggtcggggag tatatcggac acaccgccca aaagacgaga gatttaatca aaaagtcatt 1633021 aggtggcatt ttgtttatag acgaagccta ctcgctggca agaggcggcg aaaaggactt 1633081 tgggaaagaa gcgatcgaca cacttgtaaa gcatatggaa gacaaacagc atgagtttat 1633141 tttgatactc gccggatatt cacgggaaat ggatcatttt ctctcgttaa atcccggact 1633201 ccaatcaaga tttcccatct ccattgattt tccggattac tctgtgaccc agctcatgga 1633261 gattgcgaaa cgaatgatcg atgaaaggga ataccagctc agtcaagaag cggaatggaa 1633321 attgaaagat tacttaatga cagtgaaaag cacgacaagt cccattaaat tcagcaatgg 1633381 acgttttgtc agaaatgtga tcgaaaaatc gatcagagca caagccatga ggcttttaat 1633441 gggagaccaa tacttaaaaa gcgacttgat gaccatcaaa agccaagatc tttccattaa 1633501 agaagaagca tctggatctg catagacctc tcagtttttg agaggtctgt tttttgctcg 1633561 tatttccgct tttcaaagca atcgatttgt ggtatacaca tgcagggttt ggtatgataa 1633621 tactactgcc caatatgcaa aagaaaggaa catccatttg aacgaacaag aaacgattca 1633681 ggagaaagcc attttagtcg gatgtcagct gccgcatatc acggatgagc attttgaaaa 1633741 ttctatggaa gagctagcat ctctgacgaa aacagcagac ggaaaagtac tgaccagcgt 1633801 cacacaaaaa cggaacaggg ctgacgccgc tacatatata ggaaaaggga aggtagaaga 1633861 gctgaaggca ctcgtggaag agcttgaagc tgatctcctc atctttaatg atgaactgtc 1633921 gccaagtcag ctgaagtcat tggcaacagc aattgaagtg aagatgattg accgcacgca 1633981 attgatatta gatatttttg caaagcgggc gagaacgaga gaaggcaaac ttcaaattga 1634041 gctggctcag ctgcaatatg cactgccgcg tctgacggga caagggatca acctttcccg 1634101 gcaaggcgga ggaattgggg caagaggtcc cggggaaacg aaactggaaa ccgaccgccg 1634161 ccatatcaga aatcgcattc atgaaatcaa cacacagctt tccactgtca ttcgccatag 1634221 aagccgatac cgtgaaagaa gaaagaaaaa cggtgtgctt caaattgcgc ttgtcggcta 1634281 tacaaacgca gggaaatcaa catggttcaa ccgcctgacg agtgctgaca gctatgaaga 1634341 agacctcctg tttgccacgc tggacccgat gaccagaaaa atggtcctgc caagcggcta 1634401 cagtgttctt ctttcagata cagtaggatt tattcaggat cttccgacga cattgattgc 1634461 tgcattccgc tcaacgcttg aggaagtaaa agaagcggat ttaattctgc atttaattga 1634521 ttcttcaaat gaggattatg cgggacatga aaaaacagtg cttcggctgc ttgaggagct 1634581 tgaagcagat gatatcccga tgctgacggc ttacaataaa cgtgatcaaa aactgcctga 1634641 ttttataccg accgccggaa gggatcacat tatggtcagt gcgaaatttg aggacgacgc 1634701 tgcagccttt aaagaagcga ttcagcgcta tttgcgccaa gaactgttaa cgtcttttga 1634761 agcacatgtg ccggcaagtg aagggaagct cctttccaga atcaaatcgg aaacgatggt 1634821 agaccgcttc tattttaatg aagaaaatga acagtatgac atatccggct atgtccaaga 1634881 agagcaaagt atcatcggtg aattaaagaa gtatatgtag gaaggaaata taaagacatg 1634941 tttgacacat taacacacgg agaattattg aagaaaacgg caatggaagt ggaagcggac 1635001 attgccggca ttcataaaca aatagaagaa atcagcgagc gaaatgagtg gagagtgctt 1635061 caaagctata gaaaacacaa agtaagcgac actcatttca cgccgtctac tggatacggc 1635121 tatgatgata tcggaagaga cacgcttgaa agcatatatg cggatgtgtt tggcggagaa 1635181 gcggggcttg taaggccgca aatcatttca ggcacacatg ccatctcaat tgctttgttc 1635241 ggtgtcctca gaccggggga cgagctcctt tatatcacgg gcaagccgta tgatacgcta 1635301 gaggaaattg tgggcgtcag gggtggagaa aacgctggtt cgttaaagga ttttcaaatc 1635361 ggctataatg cggttgatct gacgaaagac ggaaagatag actatgatgc agtcgccgct 1635421 gcgatcaatc cgaagacaaa agtaatcggc attcagcgct caaaaggata tgcgaatcgc 1635481 ccttctttct taattagtga aataaaagaa atgatccgtt ttgtaaaaga aatcaatgaa 1635541 aatctgatcg tctttgtgga caactgttac ggagaatttg tggaagagct tgagccttgc 1635601 catgtcggag ccgacctgat ggcgggatct ctcattaaaa atcccggcgg cggccttgcg 1635661 aaaacaggcg gctacctcgt cggaaaagcg aaatggattg aagcttgctc ataccgtatg 1635721 acgtcacccg gcatcggcag agaagcgggg gcatctcttt actcgctcca agaaatgtac 1635781 caaggcttct ttttggcgcc tcacgttgtg tctcaaagtt taaagggagc ggtgtttaca 1635841 gcgagattcc ttgaaaaact cggcttcact tcaaacccga aatgggatgc gaaaagaacg 1635901 gatttaatac aatccgttga gttttctgac agagaaaaga tgattgcttt ttgccaggct 1635961 attcaatttg catcgccaat caatgctcat gtgacgcctt atccagccta catgcctgga 1636021 tacgaggatg atgtcattat ggcagcaggg acgtttattc aaggagcaag catcgaatta 1636081 tcagctgatg gccctatccg cccgccgtat gtagcgtatg ttcagggagg attaacctat 1636141 tcgcatgtga agaatgccat atgcagtgca gtggattcat tgatgcaaaa gcaattaatt 1636201 taaatttttt aaaaatttct ctggatttga tgttaagaat ccttacatcg tattgacaca 1636261 taatataaca tcacctataa tgaaactaag ttaagaaaag gaggaaattg agatgagtga 1636321 taatattcgc cgctcaatgc ctttatttcc aataggaatt gtcatgcagt taactgagtt 1636381 atcagcaaga caaattcgat attatgagga aaatggactg atatttccag ccagaagtga 1636441 aggaaataga cgattatttt catttcatga tgtagataaa ctgttagaaa tcaagcacct 1636501 gatagaacaa ggtgtaaaca tggcaggaat taaacagatt ctggcgaaag ccgaagccga 1636561 gccagaacaa aaacaaaacg agaagacgaa aaaaccaatg aaacatgatc tgtccgatga 1636621 cgaactgaga cagctcctga aaaacgagct catgcaagcc ggccgttttc aaagagggaa 1636681 tacattccgt caaggcgaca tgtcccgctt ctttcattaa tccgttagca actgttttgc 1636741 tatatacatt taccttttaa gaggaggaat tttaccaaat ggcaaagtac actagagaag 1636801 atatcgaaaa attagtaaaa gaagaaaacg tgaagtatat ccgccttcaa tttactgaca 1636861 ttcttggaac aatcaagaat gttgagattc ctgtaagcca gcttggaaaa gcgcttgata 1636921 ataaagtcat gtttgacggt tcttctattg agggattcgt tcgtatcgaa gagtcagaca 1636981 tgtacctgta tccagatcta aatacatttg ttatcttccc atggacagct gaaaaaggta 1637041 aagtagcacg tttcatctgt gatatttaca atccggatgg cacacctttt gaaggtgacc 1637101 cgcgaaacaa cttaaaacgg attctgaaag aaatggaaga cctcggcttc agtgatttta 1637161 accttgggcc tgagcctgaa ttcttcttat tcaaattgga cgaaaaaggc gagccgacgc 1637221 ttgaactaaa cgacaaaggc ggatatttcg acttagctcc aactgattta ggagaaaact 1637281 gccgccgcga tatcgtactt gagcttgaag agatgggctt tgaaatcgaa gcgtctcacc 1637341 acgaagtagc acctggtcag cacgaaatcg actttaaata tgctggagca gtccgctctt 1637401 gtgatgacat ccaaacattt aaactagttg tcaaaacaat tgcccgtaaa cacggcctgc 1637461 atgcgacatt tatgccaaaa ccattgttcg gtgtaaacgg ttcaggtatg cactgcaatc 1637521 tatcactctt caaaaatggt gttaacgcat tctttgacga aaacgcagat cttcagttaa 1637581 gtgaaacagc gaagcacttc attgcaggta tcgtgaagca cgcaacaagc tttacagcag 1637641 taacaaaccc gacagtaaac tcttacaaac gtcttgttcc tggctatgaa gcaccttgtt 1637701 atgtagcatg gagcgcgcaa aacagaagcc cgcttatccg tatcccggct tctcgcggca 1637761 tcagcacacg tgttgaagta cgcagtgtag acccagctgc aaacccatac cttgcactta 1637821 gcgtattgct tgctgcagga ttagacggaa tcaaaaacaa actggaagcg ccggctccaa 1637881 tcgaccgcaa catctatgtg atgagcaaag aagagcgcat ggaaaacgga atcgttgacc 1637941 ttccagcaac acttgcggaa gcactagaag aattcaaatc aaacgaagtc atggtcaaag 1638001 cgctgggcga gcacctattc gaacacttca tcgaagcaaa agaaatcgaa tgggatatgt 1638061 tccgcacgca agtacatcct tgggaacgcg aacagtatat gtctcagtat taatatctca 1638121 atcccttggc actaaaagtg tcaggggatt ttttatgtta ataggtaata aattatggag 1638181 cggcatagtg tttaacacag ccattaatcc tcagacagtc aaatagccat ttctactccg 1638241 gttgaaagct tctctatttt tgcttcttat ttatctttcc tgtattgata tatgtatgta 1638301 gggttggact tataacataa actattctgg ccattccgtt ctttcaattc atgaccgggc 1638361 ttgccatcag cataaatcta ggctaacagt ctccatacat cctgtgatca cctttatcaa 1638421 actcttaaat gcaacttacc actaaccaat tctttatttc gcatagatca tctttgtcat 1638481 gtgtttacac aagaatctgt tttggactga gacactgaat ataacaaaac agtcaaaaat 1638541 caatatttaa ttcattctgt ttaaactttc tgaaaaagat gttgaaaaag tcgaaaggat 1638601 tttataatat taagtcaagt tagtttgttt gatcaacaaa ctaatgaaat gaactttcat 1638661 tatccacaag ataagatctt actaatatgg atggaagggg gataagaggg tcgatttaat 1638721 ggagctaaac aatataagaa acgaaagaat gaggctttta tccttttcca ggtatataag 1638781 gtatgacgaa aaaagatgaa ttttttgctt gctgatcacc atattttttt gcactgtttt 1638841 gaaagcgctt ttataaaagt ttactgaccg taaattcgag aaattgttat accgtttcac 1638901 actgttccat attaaaggat cgaaaagggg agaaatcatg ctcagtgaaa atgtaaagaa 1638961 gattagcatg gttgaaaaag ttggatatgc gtctggagat tttgcttgta atttaattta 1639021 tgcaacagtg tctacgtatc ttttgttctt ctatacagat gtttttggtt tatcggcagc 1639081 agcagccggt actatgtttt tagtggttag aataatcgac gctctcgctg atccttttat 1639141 cggaacaata gttgacagaa cgaacagcag atttggacgc tttagaccgt atcttttatt 1639201 cggagctttt ccatttgtca tactggcaat actctgtttt acaacaccag acttttcgga 1639261 tatggggaaa ttaatatatg cctatataac ctatgttggc ttgtcgctta catacacaac 1639321 gataaacgtt ccatatggcg cgttaacttc tgcaatgact agaaataatc aagaagttgt 1639381 tagtataact tctgttcgca tgttatttgc gaatcttggg ggacttgtcg ttgcattttt 1639441 tgttccctta ctggctgctt atttaagcga tacttccggc aacgagtctc ttggctggca 1639501 actaaccatg ggtattttgg gaatgatagg cgggtgcctt ttaatctttt gttttaaaag 1639561 cacaaaagag cgggtcactc ttcaaaaatc cgaagagaaa attaaattta cggatatatt 1639621 tgagcagttt cgtgttaatc gtccacttgt tgtattaagt attttcttta ttattatttt 1639681 tggagtgaat tccatcagta attcggttgg catttactac gtaacgtata acttagaaag 1639741 agaggatttg gtgaagtggt acggtttgat aggaagttta cccgctttgg tcattttacc 1639801 gtttattcca aggcttcatc aatttttggg gaaaaagaaa ttactaaact atgcattatt 1639861 actgaatatt ataggcctct tagctttact gtttgttccg ccaagtaatg tttacctcat 1639921 acttgtctgt cgattaatcg ctgctgctgg aagtctcact gccgggggat atatgtgggc 1639981 gcttattcct gaaacaattg aatatggaga gtacaggact gggaaaagaa tgggtgggct 1640041 catttacgct ataatcggat ttttctttaa gtttggtatg gccttaggag gagttgttcc 1640101 gggtctggtt cttgataagt ttggatatgt agcaaatcag gcacaaaccc cggcggcctt 1640161 aatggggatt ttaattacaa caaccattat tcccgtgttc ttgcttgttc tagctttaat 1640221 tgatattaat ttctataact tagatgagaa aaaatataaa aacatggttc gagaattaga 1640281 gaatagagac aaagtttatt tggatcatat tgatgatttc aaggcttaaa aaagaaaata 1640341 aactgaggag gagtcccaaa tgaagattac caatcccgta cttaaaggat tcaatcccga 1640401 tccaagtatt tgtagagcag gagaggatta ttatatcgct gtatctacat ttgagtggtt 1640461 tccgggagtc cagatacacc actcaaaaga tttagtaaat tggcacttag ttgcacatcc 1640521 attacagaga gtttcacaat tagacatgaa aggaaaccca aattcaggtg gagtttgggc 1640581 accatgttta agctatagtg atgggaagtt ttggctgatc tatacggatg ttaaggtagt 1640641 agatggcgca tggaaagatt gtcacaatta tttagttact tgtgaaacga ttaatggtga 1640701 ttggagtgag ccgattaaat taaatagctc ggggtttgat gcttctttgt tccatgatac 1640761 ggatggaaaa aagtatttat taaatatgtt atgggatcac cgtattgatc ggcactcatt 1640821 tggaggaatt gttatacagg aatattctga taaagagcaa aaattaatcg gtaaaccaaa 1640881 agttatattt gaaggaactg atagaaaact gacagaagct ccgcatcttt atcatatcgg 1640941 gaactattat tatttattaa ctgcagaagg aggaacacgg tacgaacatg ctgctacaat 1641001 tgctcgttct gcaaatattg aggggccata tgaagttcat cccgataatc caattttaac 1641061 gtcatggcat gacccaggaa atccattgca aaaatgtggt catgcatcca ttgttcaaac 1641121 acatacagat gagtggtatt tagctcattt aacgggacgt cctattcatc ctgacgatga 1641181 ttcaattttt cagcagagag gatactgtcc tttgggcaga gaaacagcta ttcaaaaact 1641241 ttactggaaa gatgaatggc cctatgtagt aggtggaaaa gaaggaagct tggaggtaga 1641301 tgcaccttct atacccgaaa caatatttga agcaacgtac ccggaagttg atgaatttga 1641361 ggattcaaca ttaaatataa attttcaaac tttaaggatt ccattcacga atgaattagg 1641421 ttcattgact caagcgccaa atcatttacg attattcggt catgaatcat tgacctcgac 1641481 atttactcag gcatttgtag ccagacgctg gcaaagtctc cattttgaag ccgaaactgc 1641541 tgttgagttt tatccggaaa attttcaaca agccgctggg ttggtgaatt actacaatac 1641601 agagaactgg acggctcttc aagtcacgca tgatgaagaa cttgggcgca ttcttgaatt 1641661 aacaatatgt gacaactttt ctttttcaca gccattaaat aataaaattg ttattcctcg 1641721 tgaagtaaag tatgtatatt taagagtaaa tattgaaaag gacaaatatt attatttcta 1641781 ttcttttaac aaagaagatt ggcacaaaat tgacattgca ctggaatcga aaaaattatc 1641841 agatgattat atccgtgggg gaggattctt cacaggggcc tttgtaggga tgcaatgcca 1641901 agataccagt ggtaatcata ttccggccga ctttagatat tttcgttata aagaaaaata 1641961 atttgcacat gaaaaaggag atttctattt tagaactcct ttttcatatg agaaggtgcc 1642021 atgtcactat tgcttcagaa atactcctag aataaaaaaa ctcatcttta aagatgagct 1642081 gtccattcca taaaaaatta cattgtaatc atgtccagaa aatgatcaat cacaatggag 1642141 gacattccta atgccggtgc attctgtcct aaggaagatg gcaataattc atagctattg 1642201 cctaattggg aataaaccct tgatgatact tcacttctca ttgaatttaa aaccatagga 1642261 tgcgattcaa ttatgctatt tcttaaaatt acggcttgtg ggttgaaagt atttagaata 1642321 ttggtaaggc ctattcctaa atagaatcca aaattttgta atgcatttaa ggttccgata 1642381 tcattcagat gggcgaggtt tatgatatct tgataggaca gttttttctc tttggtctga 1642441 agagatttta ataaagcctt ctctgaagca tacaattccc agcatcctcg gtttccgcaa 1642501 ctgcatttag gaccattaaa gtctattgtc atatgtccca tttctccaga gaagccgctt 1642561 actcctctat ataaatgatt gttgataata acaccgatcc ctattcctgt gctgatactt 1642621 acgtaaataa tgttatcgtg attttttgca gctccaaata ctttttctcc atatgcgcca 1642681 gcatttgcct cattttcaat aaaaacaggc acattgtact tctcttgtat cgaagatttt 1642741 aagtcaatat ctctccagtt ggagttcgga gtgaaaacaa ttttttgatc tttatcaatg 1642801 agtccaggca cgcaaatacc tataccaata agcccgtacg gagattgggg catttgcgta 1642861 ataaagtgat gaatcatatc aatcaaaatg tctttcgtta tttctggaga attggattcc 1642921 aaatggcggt attgatcaag aacgattgtt ccttcaaggt ctgttaaaat gccattaata 1642981 taatccacac caacatctat tccaacggag tatcctgcct ttttattaaa aacaagcatg 1643041 acaggtcttc ttccgccact tgattgtcct tgacctattt caaataccat actttctttc 1643101 attaacgtgt ttacctgtga tgagacagtt gatttattta atccagtcat ttcagataat 1643161 tttgctcttg aaataggtga atttttaagg atttctttta ataataactt ttgatttact 1643221 tttttgacaa aggtttgatc agcgatatcc acttcatcca ctccatttgt ttaatcttta 1643281 aattaagtat caacatagta catagcgaat cttcccttta ttatatctaa tgtgttcata 1643341 aaaaactaaa aaaaatattg aaaatactga cgaggttata taagatgaaa ataagttagt 1643401 ttgtttaaac aacaaactaa taggtgatgt acttactata tgaaataaaa tgcatctgta 1643461 tttgaatgaa tttattttta agggggaaat cacatggctc aatctcattc cagttcaatc 1643521 aactattttg gaagcgcaaa caaagtggtt tacgaaggga aagattcgac taatccttta 1643581 gcatttaaat attataatcc tcaagaagta atcggcggaa aaacgctgaa agagcatttg 1643641 cgattttcta ttgcctattg gcatacattt actgctgatg gtacagacgt ttttggagca 1643701 gctacgatgc aaagaccatg ggatcactat aaaggcatgg atctagcgaa gatgagagta 1643761 gaagcagcat ttgagatgtt tgaaaaacta gatgcaccat tctttgcttt tcatgaccgg 1643821 gatattgcac cagaaggcag tacgctaaaa gagacaaacc aaaatttaga tatgatcatg 1643881 ggcatgatta aagattacat gagaaatagc ggcgttaagc tattatggaa tacagcaaac 1643941 atgtttacga atccccgttt cgtccatggt gccgcgactt cttgcaatgc agatgtgttt 1644001 gcgtatgctg cagcacaagt gaaaaaaggg ttagaaacag caaaagagct tggcgctgag 1644061 aactatgtat tttggggcgg ccgtgaagga tatgaaacat tgttaaatac cgatttaaaa 1644121 tttgagcttg ataatttggc tagatttatg catatggcag tggattatgc gaaggaaatc 1644181 gggtacacag ggcagttttt gattgagcca aaaccaaaag agccgaccac ccatcaatac 1644241 gatacagatg cagcaacaac cattgccttt ttgaagcaat atggcttaga caatcatttt 1644301 aaattaaatc ttgaagccaa tcatgccaca ttagccgggc atacattcga acatgaatta 1644361 cgcatggcaa gagtacatgg tctgcttggc tctgttgacg caaaccaggg tcatcctctt 1644421 ttaggctggg acacggatga atttccgacg gatttatatt ctacgacatt agcaatgtac 1644481 gaaatcctgc aaaatggcgg ccttggaagc ggcggattaa actttgacgc gaaggtcaga 1644541 agatcttctt tcgagcctga tgatctaata tatgcccata ttgcagggat ggatgcattt 1644601 gcaagaggat tgaaagttgc ccacaaatta atcgaagatc gtgtgtttga agatgtgatt 1644661 caacatcgtt accgcagctt tactgaaggg attggtcttg aaattataga aggaagagct 1644721 aatttccaca cacttgagca atatgcgcta aatcataaat caattaaaaa cgaatctgga 1644781 agacaggaga aattaaaagc gatattgaac caatacattt tagaagtata acaggataag 1644841 ctccagatcc tgctatcaat accaagtcac tgaattaccc gtcatgattc ctttcctatt 1644901 gcttgttgtt atgacgggta acttctataa ttaggattta tttagagtga atggtttttt 1644961 aaaagggcaa ggagtgaaaa aatgaagtat gtcattggaa tagatcttgg aacgagtgct 1645021 gttaaaacca ttttagttaa ccaaaacggc aaggtttgtg cagaaacgtc caaaaggtat 1645081 ccgctcatcc aagagaaggc gggatatagt gagcaaaatc ctgaagactg ggttcagcaa 1645141 acaattgaag cattggctga attggtttct atatccaatg ttcaagccaa ggatattgac 1645201 gggataagct attcgggaca aatgcatgga ttagtactgc ttgaccaaga tcgtcaggtg 1645261 ttacgtaatg caattctttg gaatgatacc agaacaacgc ctcaatgtat aaggatgacc 1645321 gagaaatttg gcgatcatct tcttgacatc acaaaaaacc gtgttttaga agggtttaca 1645381 ttacctaaaa tgttatgggt aaaggaacat gaacctgaac tttttaaaaa aactgctgtg 1645441 tttttgcttc cgaaagacta cgtgcgattc cgtatgaccg gtgtcattca caccgaatac 1645501 tccgatgcag caggaacttt acttttacat attactcgca aggagtggag caatgatatt 1645561 tgcaatcaaa ttggtatttc tgcagatatt tgtcctccgc ttgttgaatc tcatgattgt 1645621 gtaggatcgc tgcttccgca cgttgccgcg aagaccgggc tattagaaaa aacaaaagtg 1645681 tacgctgggg gagcagataa tgcttgcggc gctattggag caggtatcct ttcttccgga 1645741 aaaacattat gcagtattgg gacgtcaggg gtcatacttt cctacgaaga agaaaaagaa 1645801 agagacttta aagggaaagt ccactttttt aatcatggaa aaaaggattc tttttatacg 1645861 atgggcgtca cgctcgctgc aggatacagc ttggactggt ttaaaagaac gtttgcacca 1645921 aacgaatcgt ttgagcaatt attgcagggg gtggaagcta ttccgatagg agccaatgga 1645981 ctgctataca ctccttattt ggttggtgaa agaacgccgc atgctgattc ttctattcgg 1646041 ggaagcttga tcggaatgga tggagcccat aatagaaagc attttttgag ggcaataatg 1646101 gaaggtatca cattctcttt acatgaatca attgagctat tccgcgaagc gggaaaatca 1646161 gttcatactg ttgtttctat tggtggggga gctaaaaatg atacgtggct gcaaatgcaa 1646221 gctgatattt tcaatacgag ggtaattaag ttagaaaatg aacaagggcc agctatgggg 1646281 gctgcaatgc tggctgcctt tggaagcggt tggtttgaat cacttgaaga atgtgcagag 1646341 cagttcattc gtgaggctgc tgcattttat ccaaaggcgc aaaatgttca aaaatataaa 1646401 acactatttg atttgtataa gaacatttac actcacacaa aggatctcaa tacagctttg 1646461 aagagctttc gaaaaaacta atgatgttat tgtctggaga tcaaccgaag aacaattaat 1646521 gatcaatcat catcaaaggc ctttgataac atggctgcct tcttttgaaa agatggtgag 1646581 aataaggtat cgcaaccttt aaacagtatt ggagtatcca gcagacaaaa cgaacgagtg 1646641 gaaccgtatt ttgtcagcga acacttcaag aagtggggaa gcttaggaat gccaatgggt 1646701 aagatgtatg aaaccgcgct aacgacggta gagggatctc ttgatttatg aagaaatagg 1646761 aaggatgtta acacacaaat aacccctcac attgacgtga aggggtgttt tttattgtta 1646821 ctatacagcg gaaattttac aggctagttg catgatttta gcttgttaag cagaatggaa 1646881 ctagactctc catcatctct ttctcattct ttggaaactg cattctgcta ggtttgctgc 1646941 tttttttaac aaacagtgtt tttctatttc acacagccat taaatcctct gttcgtcaca 1647001 taaccgctct tactccaaat tgacagttta tctgattttg cttcttgctc atctagtctg 1647061 aattggtcta tgtattttgt gttaggctca tatacatatg ctactctggc caatccctct 1647121 ttcaataatg tctcttgaac agatttgccg tcaacataaa cgtatgctaa cagtcttcca 1647181 tacttatctc tgcgatcgcc tttatcaaat tccagctgta gcttaccgct gttgaccaat 1647241 tctttatttc gtttcgacgc atcctcaccg tatggttgaa cacaagaatt tggtttcttc 1647301 gtctcaggtg tatcaacgag caagtagcga actgtgtctt tctttccgtt gtaaataacc 1647361 ttaatcgtat ctccatctat tgctctatct aatgtaacat tgaccaattt cttctgattt 1647421 tttgaatgag gcgtgccagc cttttgttct gtctgattat attcattaga gtgagtatct 1647481 tgagagactt gctccgtccc attagaatct gaatggtttt tggctgcgtg atttgatccg 1647541 caagctgcca aagtaatact taaaacgatt gcgatcatac tgatcaaaat cttcttcata 1647601 ttgattccct ctttatcatt ttctcttttc gcgattaaac atcatcatta taacgatatg 1647661 gacatttttt gtgaatggaa aacttcaagg gaacttataa cactccaaat tgccaatagt 1647721 taacttcaca acgagatgat caaaacatca ccatcacata gcggaaataa ataatcctga 1647781 aaataatatt gactgaaaat gcttttagaa ttatgataat atgagaaatg acaataatgt 1647841 gacaaagaca ttactacaac ataacaacta atagcttagg tttattctat tggttaaaaa 1647901 tgtaaacggt tacaaatcca gaggcgaaaa tctaagatag agatgacttt agttttgact 1647961 caatatccac actgaaagag cttattaagt attcttaaag gcaggggaaa tggatatgaa 1648021 tgaacatcga aatcgaaggt tgaaattaat aatgatttca gcaacttttg gagggcttct 1648081 ctttggatat gacaccggag ttataaatgg agctttacct tttatggcaa ggccagatca 1648141 gcttgattta acacctgtta cagaagggct tgttacgagt attcttttat taggtgccgc 1648201 gtttggagcg ttgttatgcg gaagattggc tgatcgatat ggccgccgta aaatgatcct 1648261 taatctttcc tttttatttt tcctggcatc actgggaaca gcgttagcac ctaatgtttt 1648321 catcatggcg gtctttcgtt ttttactggg gctggctgtt ggaggagcct cggcgatggt 1648381 gccggccttt ttagcagaaa tggcaccgca tgaaaagaga gggcgtatgg taacccaaaa 1648441 tgaactaatg attgttggcg ggcaattttt agcatatgtt tttaatgcga tcctcggtgt 1648501 aacaatggca aatacgggac atgtttggag atacatgcta gtcatttgtg ctgtaccggc 1648561 tatcatgtta tttgccagta tgcttaaggt accagaaagc ccccgatggc taatctccaa 1648621 aggcaaaaac agtgaggcgc tgcgagttct taaacaaatt cgagaagata aacgtgcaga 1648681 agctgaatgt agagaaattc aagaagcggt agaaaaagat acagcactag aaaaggcatc 1648741 actcaaggac ttttctacac catggctgcg ccgtctttta tggattggaa tcggtgttgc 1648801 catcgtgaat caaattacag gtgtgaactc gattatgtat tatggcacac aaatccttaa 1648861 agaatctggt tttggtacaa aagcggcttt aatcgctaat attggaaatg ggctgatatc 1648921 agttattgca gttatatttg ggatttggct ggtcggaaaa gtgagacggc gtccaatatt 1648981 attgattggt ttggcaggga cgactacagc gctcctattg attgcgattt tctcaattgt 1649041 gcttgatgga tctatggcac ttccttatgt agtgctttct ttgaccgttt tatttcttgc 1649101 ctttatgcaa gggtgtgtag gacctgtgac ttggcttgtc atagcggaaa tattccctca 1649161 aaggttaaga ggacttggtt ctgggataag tgtttttttc ctttggatat taaactttgt 1649221 gatcggtttt gctttcccga tcttgcttag ctctgtaggt ttgtctttta cattctttat 1649281 atttgtggct ttaggtgtat tggcaatcgg ttttgtgtac aaattcatgc cggaaacaaa 1649341 agggcgtaca cttgaagaat tagaagagca ttttcgttct cgacacgatc ataatactcc 1649401 tgaacaatca gttattgagg tataaatatg ttgaaaatct ctcttcttat aggagggatt 1649461 tttttagttt cagaaaaaac aaaatccctc tggtagaggg attttgattc agcattttaa 1649521 gatgttctac acgtataata ctggagttga tactttaaaa atctcgccat ctcttatata 1649581 aaaacgaggg atgcggcggc ttaatgtaga cacgacttca tagttaatcg tattgagcat 1649641 ttcagccact tcatcaacgg aaatctcggc tcctttttgc ttaccgtaaa tcacgacttc 1649701 atctccttgt ttaccttcac cgttttctcc taaactgacc atgatcatat ccattgttac 1649761 tcttcccgcc actggcactc gttttccgcg atgaagaaca aacccgcgat tggaaagggc 1649821 acgagaatag ccgtcagcat agccaatcgg gagtgtagca attacttcat taggttctgc 1649881 gatgtatgta gcaccatagc taacggttcg gggttctgtc cgcatggttt tcacataagc 1649941 gatgcgtgcc tttaaactta acgcaggttc aagcttaacg agatttagtt gtttaatata 1650001 ggctgaagga tataaaccat ataagccgat acctaaacgg atcatatcag cgctaaattc 1650061 cggaaatgcg atagctgcag ccgtgttgca catatgcacg gtgggcagct caatcccctg 1650121 tttttttaaa aagctgagaa aactgatgaa tttttcatgc tgcagctttg tgagtgttgt 1650181 gtccggttca tcagctgtcg aaaaatgtgt gaaaatccct gtccatctga ggaatttact 1650241 tgcctttaag gctttcacta cctctaaaag ttcttccttt gtgcgtacac ctaatcgtcc 1650301 catgccggta tccacgttaa tatgaatggc cagccggtta gcactcgctt ctttttccaa 1650361 tatctcgttt gcttctttca tccaatcaac ctgaaatgct gataatgtta tattccaagc 1650421 tgctgacttc tttacacaac taagggatgt aaaaccaagc acaaggatag gtgctgtaat 1650481 cccagcttta cgtaaaacga ttccttcctc cacactggca acagcgagct cactcgcccc 1650541 gtgttccagt gcatggcgtg ccacttctat agacccgtgg ccataaccgt tcgcttttac 1650601 aacagccata attttgctct tatgtggaat atgacggcgg atcgctcgca aattcttttt 1650661 aacggcatca agattgactt cgatccaaac ttctcggcaa agctttatca tcaacgcttc 1650721 cttccttctt atggattata aataccacct attgccgcaa gaataaatgt taattgttgg 1650781 atgattcgat cttattttat tcaactttat ttgaaatcat tcaacagcaa atccatgtga 1650841 tacgagaagg tgcctatcaa tgttcgaata atagcaagta cgggatacat gaggcttgta 1650901 agtggggtgt taatggatgc ggcgaccgag gattacaaaa atgattattt gttttgggac 1650961 atttttttct aagggtagat gataacgaga aatctaatca ggaaatactt accgttgtta 1651021 tgaacattga agaacctttt aaatgagaag ggctgaggaa attctgtaaa agataatcgg 1651081 ttgaaaaggc agtcgattcc ttgttccata aacctaacat cagagtatat aattatactc 1651141 gtattcacaa aaatcgttta agtaaggggt atacatgaat aggggagtta gttttcaaat 1651201 accgaatgaa tatggaaatt ttctatggag aatactgcag ccggtagaaa tagctaatta 1651261 taggtggcaa acgagtgggg aatcttattt tgttgtagaa ggagagctcg atgatgagga 1651321 gctttttcat gactacgaaa ttgttgaggg ggcagttttt gagcaacaat taaaaacgaa 1651381 tcagtactat accattttcg ttgaactgaa agcatttcca tatggaaaaa tggttaatca 1651441 agtcaataca tatgaagagt ttgctgacag tgattgcgaa cttgtccttt tgatagcaga 1651501 taatagctac gtttcgattt actgtaaaaa caaaaatatc attgaaaaac tttacttcaa 1651561 tgctttacag catgattttg aagacgttca atttataact gatgaaaatg acacaagaac 1651621 aagccttact gtatgatact caataaaaat taaaggagct agtacatgac aatgcaaatt 1651681 aaaatcaagt atctagatga aacacaaaca agaatcagca aaattgagca gggagactgg 1651741 attgatcttc gggcagctga agatgtaaca atcaaaaaag atgaatttaa gcttgtccca 1651801 ttaggtgttg caatggagct gcctgaaggt tacgaagcac atgtcgtccc tcgttcaagt 1651861 acatataaga actttggcgt tattcaaaca aattcaatgg gtgttatcga tgagtcatat 1651921 aagggagaca acgatttctg gttctttcct gcttatgcat tgcgtgatac tgaaattaag 1651981 aagggtgatc gtatctgcca gtttagaatc atgaagaaaa tgccggcggt tgaattggtt 1652041 gaagtcgagc atttgggaaa cgaggataga ggaggactcg gttcaacagg tacgaagtaa 1652101 acaaaataaa tccttggctg tcttcatgct gtgtgattga tcaatggagg tttcagccaa 1652161 ggtacatata aatattatgt ataaaatgaa tattttaata cgaaggattt aattaaaaac 1652221 aaagtttaaa aagggaagtt ttgaaaaagt gaaatagtaa taactaaagt cgataaagaa 1652281 cctaaagatg tcaaagaaac aatttttctg gtgctttgct tttttgaagg tttacttagc 1652341 tcgtggataa ctgcccccca taaaagcatg gatgctaaaa ttataatact tatatacata 1652401 aagatgctcc ttttattata tttacagttt ttacattttt atcgatttta ccacatttag 1652461 gattgagttg tcgatgaaac aagcatctct ataaagaaat acttttatct aaatttttat 1652521 aaatagggga aggcaactaa aaactagtaa tgccactaat aataagccaa gttaaatgac 1652581 ttgtgttcat taataattga attttacagc agccatgagc acaaaaaaat ctgagttcgt 1652641 cgataaatat cataaaaaag cccccggtat gtcgccaggg aataaataga cgtttaagag 1652701 atttagtgat gttttttata tgattcgaca aaatcataat aatgatcatc gtcatcataa 1652761 tacttttttt cgtaatgata atcgtgatca tcgtaatact ttttatcatg gtcatcatac 1652821 tttttgtcgt aatcataatg ttttttatca tgatcataat acttgtcgca atcataatgc 1652881 ttcttatcat tgtcgtaata ctttttgtaa tatgtttttt tccaagtata atactcttct 1652941 ttatattttt tataataacc caattaaatt cctcctttat gttattcgaa tttaatttat 1653001 gaagtttaaa tgatatggta tggtcaaatg aaataagaat agtaaaaaga ggctgtttaa 1653061 aacactttct gaaaaacaaa acggatagct gtttatgaaa ataagagcga gagagagcac 1653121 tcaatcactg taaaataata gtaaagtgta tagagagatt agtatacgta aaaagggact 1653181 ttctcattga agaatatttg aacgttatgg ttaagattca agagctctat gatgtgattt 1653241 ttcacactgc ttttgaagga tttagagtta gacatcaaaa acaaacagca aaaccggcta 1653301 gaaacagatc atataaggaa tgaaccgctg ccaaatatca taaaaaagtt gttaatgatc 1653361 aaatgaatga aattagagag aatttatttt aaagaaagcc caattgcaca tggacaaatg 1653421 acaattgata ttgaggtaaa atacaatgca ttaaatcaga aaaagctatt ggaggattta 1653481 atgtgtttag acaatttcca atttggtata cacaaacacc tgactatttg aatttttatg 1653541 taccgcaata tcaaaccatt tcgtataatc ctcaacaatg ttatcaacgg tgtatgtacc 1653601 aaactggcgg taactatgag ctatgtgaca gactatgtta tggagaaata caggtgtaaa 1653661 agagggggat taactcctct ttaaacacac agtgagtgga ataagatcct cactttatct 1653721 gcaagtgctt agtatttgcg ataatattgc attcgtaata aattatgctt agcaactgaa 1653781 aatgaaagaa ggatatgaat agtcatgacg caattcgata aacaatacaa ttcaattata 1653841 aaggatatta tcaataatgg aatctcagac gaagagtttg atgtaagaac caagtgggac 1653901 tcagatggaa caccggcaca tactctaagt gtaatcagta agcaaatgag attcgacaac 1653961 tcagaggttc cgattttaac gacaaaaaag gttgcctgga aaacagccat taaagagttg 1654021 ctctggattt ggcagctgaa atctaatgat gttaatgatt taaacatgat gggcgtccat 1654081 atttgggatc agtggaaaca agaagacgga accatcggac atgcatatgg atttcagctg 1654141 gggaagaaaa acagaagtct aaatggagaa aaagtggatc aggtagacta tcttcttcat 1654201 caattgaaga acaatccatc ttcacgcaga cacattacaa tgctgtggaa tcctgatgaa 1654261 ttagacgcaa tggccttaac gccatgtgta tacgagacac aatggtacgt taaacatggg 1654321 aaactccacc ttgaggtaag agcacggagc aatgatatgg cattgggaaa tccattcaat 1654381 gtattccagt ataatgtgtt gcagcgcatg attgctcaag tgactggtta tgagcttggt 1654441 gaatatatct ttaacattgg ggattgccat gtgtacacac gtcatataga caatttgaaa 1654501 attcaaatgg aaagagaaca gtttgaagca cctgaactat ggatcaatcc tgaagtgaaa 1654561 gatttttatg actttaccat tgatgatttc aagttaatca actataaaca tggggacaag 1654621 cttttatttg aggtagcggt ttaatgctgc ctttttattg tgcagtgaat agatagcagg 1654681 tatcctaatt tcattaagca atctggaaga tgaataaaaa ttgaaggaca aacacgtata 1654741 atacataaaa aagattaact ctacagttaa tcttttttat tcagaagaaa atatcctaac 1654801 tttgaaacta aatacaaagt aaaagcaatc attacagttc tagatattac aattccatga 1654861 atagctagat catatccagc aggtatcaac gcatttgtat tacacataaa atatatagat 1654921 attagaagtg ctacaataac taaaatcatt ccaaaaagac ttgttttttc atatttcata 1654981 ccaatttcca cccttattaa agttaggttt aaacaaaaga gctgaagaaa cgaactatga 1655041 ccagtatgct ccaaggaaaa ccgccagaca atgctggcgg ctttttgctg cttcgtttat 1655101 ttattaacag agatcgtaac gttatttcct gcaactgaaa cctttgcgaa atcctgtgta 1655161 tctaccacag gagtgacggc tttattgtcg atagtgatgt tgttaaaaga ggtcgaaaag 1655221 gttgctttga tcgcatcacg ctggctttca tacgaaacag ccgcggtagc aagtgttttc 1655281 cattttgaaa tcgtgccgat gttggttcct tgaatttctg tgataatccg tccggtgtag 1655341 ccgtcattgt tcgttcccca aagggtcatg cgcgtattgc cgcttaaatt tttatagatt 1655401 gtcatttgga ctgtgcttcc agggcggaag cctttattgt atgtgaattt gtcttttcct 1655461 tcgatgtacg tttcttcatt tttggaccca accttcatga ggggcttcca gacgttgtat 1655521 tgtttgctgt actgaagccc gatatcggct tcagttccgc ttgttgccct aaagccagaa 1655581 taaatatagg gagtagagac cgagtcgttg tttttgacag tttcaggaag cacgatttta 1655641 gctgtaaaaa cggcgcccgt actgttcagg tagacacggc cgccgattcc gttaggcagc 1655701 tcggatgctg cttttgcgac ttgagcgtct gccgcgggta aacctggtat acctgatgaa 1655761 agggttccga aaagaactgc tgttcctact gcacctgcaa tcaatacttt tttcaccaaa 1655821 attccccctt ttgatagtgg tttcgccatt tattatacct tattttggaa ctggatttac 1655881 gtatataaat cgacaaaata tttcattttg aatgatgtaa ggtcgaaacg cttcgccaat 1655941 ctgaaagcta tataccttta tcagaggaaa gaatgagatc acattcgttt taaccgattt 1656001 gaaattttcc tcaaaataaa agtacaaatg cttaaagaaa cgattattaa aagaatgccc 1656061 gctatcgttt ccaagcctgt aaaaaagagg tgacgtttca tcaatgtctg tccttgtaaa 1656121 atgataaaag cacagatacc gactaagaaa agaaaacaaa tacttaggat tgctaacgct 1656181 ttacgtgagt atgttttcat ttcatcttta aaatacagca atacgaaaat aaagcagata 1656241 acattggcta ttgttctaat cacctcaaag cttttcatga caactgatat aaatagacaa 1656301 agtaaaatga gataaaatac gatgtttcta tacaaaaaac ctctcctttt atgtaggatc 1656361 ctcaaagagt ttataaaagt ttctttgtaa ctgcaataaa ttgaatgcgc tcacttatga 1656421 actaactaaa ctatgtacta aatattcact attctttttc agattcagtc accaaggttt 1656481 tcatagaaag ggaagcttca gaaatataca tatagtgcac aaacaaaaaa gacccggcaa 1656541 tagccggggg aaagtaaaaa cgaggagatg ttaatggcgt ttagtagtgt tttttatgct 1656601 ttttatactc tacaacataa tcatagtctt ttttatcgtg atcataatat tttttatcat 1656661 agtcatcata ttttttgtcg taatcacagt cataatcttt tttatcatat tcgtaatact 1656721 tcttataata cgtttttttg accgtataat actcttcttt gtattttttg taataaccca 1656781 tatatactcc tcctttattt ttactacgct ttattatacg gcgagtagat tttgcggctt 1656841 ggacagttaa aatcatagaa ggaaaaaagg gctgtccaaa tgatagaaaa agacagatga 1656901 cacaaaaaca aatcaaaata aagagccgat ttttcatcgg cccaaacgat ttatcctaca 1656961 tttgtttgtc ttctttgttt tctgagtcat tttttctgat atcctgagtc agtccgcttg 1657021 ttgcttgttt aaattctgat aaggcttttc ctgctgcacg gccaagcgcc ggcagtttat 1657081 caggcccaaa tactaaaaaa cccacaaaca aaataacgag tatttttgtg aagcttaatt 1657141 ccatatcctt ttccccctga ttgaagtaca accttttaaa caaattataa gagatagcag 1657201 tacaaatggg aatgcattta ttttgaacat tttaaaacca gcacaaagac ggattcataa 1657261 aacggctgct gctgaatata atgtccaatg ccacctgcct aagaagcagg aggcaggctg 1657321 gatcaattat gtagctctgc cggaaatgat acaaacgtag cggctatcat tgacatagag 1657381 gagtggtgta gctgatgaga ttcactaagg tagttggatt tttgtctgtt ttagggttgg 1657441 ctgcggtttt tccattaacg gcacaagcag aaaaagccgg aactgcgggg gctggagagt 1657501 gggataagtt ggggacttac acatatactt actcaagtcc gacggtatac tcgaccggag 1657561 gagattttag agtgtgcctt tcaggaagca ctcctttttc tgtttcactg cacttatatg 1657621 aggatgatcc cggtgacaat cctgatgatt atgtaggggc aaactatttt tcacccggag 1657681 aatgccacac ctttggcagt attggaaaat ttgtagatgg gagcaataac aaggccgagt 1657741 tctttgttac cgattactct ggtaaatcta aaactgttac gttttatgat tgatggactc 1657801 aaattgtgaa gtataaccct tggaaaaaaa caaaaaagag agatacctct ctctttttta 1657861 ttcttcgaca gccttacgaa gccgttcatt tacaatgcca gtccagccgc catccatctt 1657921 accgcgaacg acggagcttt tctcgtttgc tttgccgatc acttcattcg gctctttcca 1657981 gccgctgtga ataagggtaa accctgtctt ttcccccaag tcttctaatt gaaaggtaac 1658041 gacccatcct tctgtatccc attcaaaaga aagttcagtt ggagcttgaa cagccaaaac 1658101 tttacaaggg gacggcccaa acggcgattg taagtgaaat tcttgtcctt ctttgagctg 1658161 aaagtcattg ggcataaacc acttggcaat gccttctgaa gtagagactg tctcccagac 1658221 tttctgaatg ggagcctcca gagtaatgct ttttgtaata tccggtaatg cattttcgtt 1658281 gttttgagcc atttcgttta cctcttgaca tatgatgttt tttcaattca atcatataat 1658341 aactaataag atcatgtcca tagcgtgcat tatttatgct agagctgctg ttgaacagcg 1658401 tgtcagtcgc cagtctgatc tgtgaatggg agaattctgc atgcgcgaaa aagagagaga 1658461 ggtgtatgtt gtcatttcgt tcattcttgt ttgcagccgc aactgttatg tttgaactgg 1658521 gattcctgtt cagccaattt attttgcgat ttttgtttta atagtaaatg agccattttc 1658581 taaaacagga ggttttttat gcttggaaaa atcaaagcag ccattgataa tagtccaggg 1658641 aagccggcca gaattttagt tagtgaaaaa gcgtttcagc aattagagga agaaatgcgc 1658701 tttgtttacg tttccaaacc gaaaacgata atggggattc ctgtggaagt ttcagatcag 1658761 gcagaaagct tcaagctgga attttagttt tcccagactg ctaaaaggct cattttgtgt 1658821 taattatgca aaatggtcag gttgatttct ttaaaagcat gatgaaatgt tcatcatgct 1658881 tttttattga gaaaaaagac gaacataaaa aataggtata cgggaaaaat aatcctatta 1658941 gagagagggg aactgacaga tggataacat gatatcaaca cttactgact ggaatgtgtg 1659001 gtttcaagcg ttagtagtat ttctcgttcc atatgtaatc tataaagtgt ttacttggat 1659061 tcatgtataa gaaggtgcaa tgatgaggtg gcggaacaat cagtacaaaa cacagaagca 1659121 gcataaatca gattattcga cagctgaaaa gcaggatcag gatgtgttaa ccggtaacat 1659181 cggatacgac ttagaacatg taaaaagaaa aataggacat aacggggacg ttcatttccg 1659241 tgagcttgaa atcactcaat tacatgtgaa agcggcattg atctttgttg aaggactgtc 1659301 tgatcaggac ttgattaata aaggactatc agtgttagtc atgaatcaac ctaatcaggt 1659361 aagcgatgaa atttctcaat ccggcaaagg tattttaact tcgaaacaga taaaaaatca 1659421 aatcgtatca atcggtgatg tcatagattc agagaaaatc agtgatatcg tgttgaatgt 1659481 tttcatgggt tcgacagcgc ttctcatcga tggaataccg caggcctttc ttctgggaac 1659541 tgtaaaaaaa caaaatcgaa gtatcgagga gccgctttca gaagcgcttg tcagagggcc 1659601 gcgcacaggc tttacagaag agttgagtac gaatacagct cttttgagac agcaaggaaa 1659661 aaatgatcaa ttaacattgc agagatttga agtaggaaca cgattaaaaa aggatttaat 1659721 tatcgcttat atgaatgaca ttgcagatcc aaaagtagtc gaggaagtaa gaaaaagagt 1659781 gagagggatt gagatcgatc atttgccgga gtcaggctac gttgaacagt taattgagga 1659841 taattatttg agcccgttcc cgcaagtaca gagtacagaa cgtcctgatc gcgtcataag 1659901 cggattaatg gaaggaagag tagctattct gcttgacggc actccgtttg ctttgattgt 1659961 tccagtcact ttcagcatga tgcttcaatc gcctgaagat tattatgaac ggtggttccc 1660021 gagctcgctc atcagattgc tgaggttcat cgcagcaatg ataacgttat tcgcacccgc 1660081 tttatatata tcatttattt cttttcatcc tgggttaatt ccgaccaagc tggcgatttc 1660141 aatttccggg acgcgccaag gtgttccgtt cccatctctg attgaagcct tatttatgga 1660201 agtcgcgatt gaaattttaa gagaggcggg gcttcgtttg ccaaaaccaa ttggacccgc 1660261 aataggcata gttggcggat taatcatcgg ggaagcagct gtgcaggcgg ggattgtcag 1660321 tccaatcatg gtcattgttg ttgcgctcac agcaatttct tcatttgcca tcccgcatta 1660381 tagcacaggt atagcacttc ggatgcttcg gtttggcgcg atgttttgtg cggcggtgtt 1660441 tggattgttt ggagtcatta tgtattatct gctgctaagc agccatgtcg taaagctaaa 1660501 gagctttggt gtgccatacg caagtccggc agtgccctat cacttaaaag attggaaaga 1660561 ctttgttatc agaatgcctc ttttagtcat gaagcgccgg cctaaaatga tgaatacaga 1660621 taatacaaaa cgggtgaagt gatgaactcg acaggatggt gataaagtct catgttcagc 1660681 ccaaccagta aaatcacaac cgctcaggca acgattatca tcattaatta tatgcttgct 1660741 gccggagttc ttacgctccc tcggacagta acagaacaaa cacaatctcc tgatggatgg 1660801 atttcagttt tattaggcgg ggtcctagcg gtaatagccg ggatgattat agctaaatta 1660861 agccagcagt atcctaagga gaccttttat gaatactccc gacatattgt aggaaaatgg 1660921 ctcgggcatc tgatcagtat tgtttttatt acttattttc tggcactcgg tgcatttgaa 1660981 gtcagagtca tgtccgaaat cgtggatttt tttctcctcg aagggacacc ttcttgggcc 1661041 atcattatga cagttctttg gattgggctt tattcaatta cacaaggcct agatccgatt 1661101 gcacggcttt ttgaaatgat ttttccgatt acggtcatca tctttttaac gatagccctc 1661161 atgagtttag gcatatttga gatcaacaat ttgcgccctg tattaggtga tggaatcatg 1661221 ccggttctta gaggtgtaaa gacaacgaac ctttcattta catgttcaga aattatgttc 1661281 attttagtag catttatgaa aaagccgaaa aatgcggtga aagcagttgt gatcgggaca 1661341 ggcgttgtga ccagttttta tatgattacg atgattatgg tcatcggtgc actatcagtt 1661401 gagggagttg tgacgagaac atggccgggg cttgacctga tgagaagttt tgaaatacct 1661461 ggtttaatat ttgaacggtt tgaatcattt ctgcttgtga tttggattat gcagcttttt 1661521 gccacgttta ttatcacttt ttatgcagct tccctgggag tctcacaagt ttttaaaaag 1661581 aaaccccttt catgtatgtt tgggctgctt cctgttatat atatcctctc ttgcatgccg 1661641 aaaaatgaaa atgacgtctt tatattgggc gatacggtca gtcatatcgc tttgtatata 1661701 tttggcgctt tgccgatttt gctgttagtc atttcgaaat ggaggaaaag aggtgaaaag 1661761 taaactaaaa cgtcaattgc ctgctatggt catagtatgt ctgctgatga tttgcgtaac 1661821 aggatgctgg agcagtcggg aaatagaaga tctgggtctc acattcgcta tcgcaattga 1661881 taaaggaaaa gaaacgaaca ctgaaaaaga gttaaaagaa gagggcggga gctatccgaa 1661941 aaaagacaac attacgctga cctatcaatt tgttaatgaa aaagcggcag gcgcgggcac 1662001 aagcggggga ggcggtagcg gacaaggagc gcaaaaagcg tacattaata taagtgaaac 1662061 aggggattca ttacagcaga tcggaagtga ggttgcatta agacgggacc gagaagtgtt 1662121 tagcccgcat ttaaaagttg ttgtcatgag tgaagatgtg ctgcacacat ttcctatcga 1662181 cgaaatgctg gatcaatttt ttcgtgataa tgaaatcagg ctgagctgtc ttgttttatc 1662241 tgctaaaggg gaagcaagag acgctctcca gctgaaagag aacggagaaa ttccggcatt 1662301 tcggctgatt ggattaggtg aaaatgaaca taaagtttcc agaattcttc cccctatgac 1662361 actcgcgaaa ctaattggaa aactgcattc tggcagcagc tttttactgc aaaatgtggt 1662421 tgcggcgaat ggagcggtca agtattccgg agcagctgta atcaacggaa aatcgaaaaa 1662481 aatgataggc accttaaatg aatatgaaac tgaggggatt acatggatta gaggagaagg 1662541 gaaaggcgga gttgtcaaaa gtcatgataa aaagagccaa cagacgttag cgtacgatat 1662601 caataaaatc aaaagcagaa ttcagccaat cgtaaaaggg aaagatattt cattccatgt 1662661 cgatattgaa tcagaaggcg atttggttga aaactggaac acaaaagagg cgttggacac 1662721 ccagtttata gatcgtctcg aaacgactat tgaaaacgag gtaaagaaaa tagttggtca 1662781 ggtattaaaa aaaattcagc atgattataa agcagatgtt gcgggttttg atgaatcttt 1662841 tagacttaca tatcctcact tatggaaaag ggtgaaaaat aactgggatg acaccttcag 1662901 taaagccgac atcacataca gtgtgaacgt cacaattact catttcggca cggttaaaac 1662961 tcagtaatga atcccaagga agagaaggaa acctctcttc tcttttttat gcatttatta 1663021 ggataaagat actttttttg gagagatata cacttttcaa atcgaccaat atgctaatat 1663081 aggaattgct tgaaatagaa gggagaaggg gctgtgaggc agaaaccgat ttatgtagaa 1663141 atcgaaatga aatctgatct ggatacactc tgggaatata cacaaaaccc atcactgcat 1663201 aaggaatggg atctccggtt ttcaaatatt acgtatttga atagtcagcc atgcgaaaaa 1663261 cagaagtttc tttacgaaac aagggtaggc tttggattaa aggtgtcagg tacaggagaa 1663321 accgtcggtg ttttcaacaa atgttcatct gaaaggtctt cttcactggc ttttggctct 1663381 gatcatccat tatctctgat tcggcatgga agcggctact ggaagtatat acagagagaa 1663441 aatgggaaaa tgacgttttt aacacagtac caatacaaaa cagcctacgg actgctggga 1663501 agatggattg atcgtttatt atttcggccg ctgcttggct gggcgactgc ctggagcttt 1663561 gatgcattaa ggctttgggt agagcaaaat aaacatccga agcgcttcat tcgatctgct 1663621 atcatctatg tgttcatgtg tctgtttttc agcctgtttt ggttctatca aggctttgca 1663681 ggtgttaaga caagcatatt gacaggaaca gcggagatag gcttagctat tttgtggctg 1663741 cttcctttaa aaagaaaatg gatcattcat ggtgtccagg cttgtatttt tgctgggttt 1663801 gcttgtctag gttccgaaat attcatgtgg gttctattga gtgtgttttc cgctgcaagc 1663861 ggcgctctta gcctgcagct ccccagtgcc aggcgcacaa aacgaaagag aaagaagtga 1663921 cattgtgagt tcgatttatg aaaaatcaat tattaactat catttgctgc atcccaagct 1663981 gcagaaacgg taccaattag acgggtctca tacattcagc gggacgggaa cgatgtcaga 1664041 aataagcgga ggctcttttc tggttagaat gctgttaaag ctgggtgttt ttttcagatg 1664101 cttcttttca gaaagaggca aagacattcc atttacaata caaaatagaa cttgtctttt 1664161 gaaatcgcaa catacaggaa tagaatggaa tcgtacattt ttctttaaag gcaaaaaacg 1664221 tttctttgat gcgttaatga tatatgacga gaaagaaaat agaatacttg atttcttcgg 1664281 caaacctcat ctgctgctgt ctgttttgac gttcgaggca tctcttgacg gctctcttac 1664341 gatcacatcg ggaaagcaat ggctattgat atgcggaaaa agaatcccgc tgccgaaatg 1664401 gctgaccggt acatccgaag tttgcgaaac gtttgatgaa aaaaagaatt gtttcaccat 1664461 tgaagtgcat gtgcaaaata caattcttgg cactcttttc ttttataagg gaacgtttca 1664521 ggaggaagag agagaatcat gaaacgaaat ggcatagtca gtgcgctttg ttttattgga 1664581 tttcttgcag cagaagcacc ggatatttca gtggcagagg cactcgtttt gttatccatt 1664641 ctatttttcg tgccgggaat ttttcctttt gtttttcgtc aatctccggt tcgtgctgct 1664701 cagtttatgg aaaacgggct aatccagtgc tatcctgtag ccgcattctt tgcggtgctg 1664761 gctctagtga cggaggttgg gggtttcgca cttatctggt ggatgtacac agtttttaat 1664821 gcattgtatg cgatcctccg cctttgggaa acaaagatac atagaatcga agagacatca 1664881 gttttgttcg gtcttattta tttggcggga ggaggatttt ggttttttgc ttatgctgcc 1664941 catttgcaga tcatgcaatt tggccctctc atcattttgc tgactgctgt ccactttcac 1665001 tattctgctt ttctgatccc gatcttcaac ggtttactcg gcagaaccat tagaaaacat 1665061 cggatgttgt acagttggat aacatgggtg attttgcttt cgccccttct tatcgcactg 1665121 ggcatcacat attcaaaaac acttgatgtc attgcggtta gcatttatat ggcggcgatt 1665181 tatcttcatg catttttggt gttcacggca gcttttcgca ccaagacggg gacatttctt 1665241 attcggcttt cttccgctgt tttaatgata acgattgctt tctcgatgat ttattcattt 1665301 ggtgtctttc ggcaagaagt tacattgacc atcaatcaga tgatttggat tcacggtttt 1665361 gtcaacgcgt ttggtgttat cttgcccgct ctcatagggt ggagaataga ggatgcgaaa 1665421 ccttttgatg cagacagtgt aaagacattc agccgtatct acggaaaaag aaagattgga 1665481 gaagaatttt tagctaacat tcaagctgaa aataacgctc ggtacagcgg acttgtggat 1665541 gatatgggca gcctgcgttc aaaagatttt tcaccagaaa aactggcgcc gctcattctt 1665601 tcgttttatg aacaaaccat cgaatacaat attaaagcaa aagtaacatg gagcacgtgg 1665661 tttcggccgc ttgcaattat ttacgaatgg ttcagcagaa gaatcggcca aatacatctt 1665721 tcgacgaacc ctgactggta taggatgtac agcaagataa aaggtgttca ttcgaaaaaa 1665781 gacggaaggg aaagagtacg tgcctggatt agaacaaatg aaaaaaacga aaccattttt 1665841 accgctcttt attcagtgta tcgttcaaat ggagaggggt atatgaatat ttctttaccg 1665901 cttccattca gcagcatgac aggtatttta aaaccatatc atcatcagga gaagctggtt 1665961 ttaacaagca ggcggagaaa aagcagagcg ggggatgagg ggatttatct gcaaacaaga 1666021 gcgggaactt gtccgcttcc tttatctgaa acctttctga tagaagctgt acatgacaac 1666081 aaattaaccg ctgttcatca tatgtggctg tttggaataa aatttctaac tgttcattac 1666141 agcattacac atattaacca gcctattgaa agaacctaac acaaagaaga agcttcgtct 1666201 gccagttgta atgagatgaa ctgttttaaa attctgcacc gcatcaagac aggaaaggaa 1666261 gggtttatgg tgttttatat cagtttattt ctgattcttt ggctggctgc tgggtttgca 1666321 gtgggaatga aacaagtgta tgtcgatcag ctgtttgata aagctgtgat cgaaagactg 1666381 gaaaaagaag cgaatgatca tggacatgct gaccggatga tcaaacagcg cgtcctttat 1666441 attgcagcag tgacagtaag cgggtttatt tctgtttatt atgaaatgaa aacaatcccg 1666501 caaaggcgaa acataagaaa aattgaaaaa aacatcatga aattaaatca agcaaaaaaa 1666561 cgaagaatga agagaaaata aaaagtgcac aggccaaagg gcaggtgcat ttttgttttg 1666621 tatggaaaat gggggaggtg gtgccagctt acttttcata aattcaaaaa tgagaagaac 1666681 agcgcccggg ctaatggtat ataatattgt gaatttaaca aaaatttaac aaggaggacg 1666741 agagaattcg tgctaaagcc tcaaagagac ctacattctg ttgatttgga cttagaggcg 1666801 gagtagatga aaccggccaa agtatccctg ctccgccgtt tgctccattc cttgaagcat 1666861 gttgattgta acatagccaa acgttttcca tcaactatta aaattgtaaa attattgatg 1666921 atttttatgg tgtttactcc gatttcttca atttatgctg aagatgtata tcagaatttt 1666981 gaggaattaa aaaacaatga agatccttct gattatggcg ttgttacgaa agaaaccgga 1667041 agccctgttc ttgttttagc tattcacgga ggaggtattg aaggcgggac aagtgaagta 1667101 gcgagagagc tcagcaaaga gtactcgatg tatttatttg aaggcttaaa atcggcagga 1667161 aactcagtcc tgcacattac gagcacacac tttgatgaac ctcgggccct taaaatgacg 1667221 ggaaatcatg aatatgtcat ttcattacac gggtacgcag aagaagatca gcagatcgaa 1667281 gtcggcggta cagatcgcgt aagagcggca gatttagttg agaaattgca gcatgccggt 1667341 tttcctgctg tattgctcaa tatggaccat ccgcatgcgg gcgttagtcc gaataacatt 1667401 gcaaataaat caaaaacagg tttaagtatt cagatagaaa tgagcacagg gtttcgaaag 1667461 tctttgttcg gcatcttttc tttaaaaagc agagctgtta ctcaaaatga gaggttttat 1667521 gagtttacag aagtgatgtt ccgttttctc aaaaatagct actgaaaaat aggaggcgat 1667581 aagacagcct cctattcctt atgcttctct ttcgtttcgg gaaacagctc gtccgcggct 1667641 tccgtttgat actgcaacgt gttatctctc gctgacagtt catttcggaa attttcatca 1667701 agcacatttt tcagtaaata ccgatgaaaa aagtattcaa aaacagtaag acaggcagcg 1667761 gaaaggagag ccgctccaaa tggtgagaaa tcgtttcttg tttgggttaa aacaaatacc 1667821 caaagaataa cgaatgaaag gccaaagtca gccaatgaag ctgtaatatt gtttgttctg 1667881 ggtaagacga gcatgtcacc agaaagatag gaaacaaaac ctaagaaaag tgcaataaac 1667941 atcacactta aaaaggatgc gtgatagact ctgtccaaaa tcacatataa aagggcgaga 1668001 gtgaaagcaa tctttgaagc aagcgcaatg atatgtttca tttgaccacc taaattgtta 1668061 ttttttgaag aaaattcttg ggcgtaaaca aatgataaat aatgcaattc aaaaccattc 1668121 ataatggtca tgttactatt ttaaacagtc cgtttttgtt tacactggta tttttttcag 1668181 ctgtatgaaa ctttcttatg aaaaaagtcg tatatgtgga tgatcagctt tcaagggggg 1668241 aatgatttgt ggagataaaa ggaatcaatc acttgctatt ttcagtttcg catttggata 1668301 catcgattga tttttatcaa aaagtgtttg gtgcaaagct tttggtaaag ggaagaacaa 1668361 ctgcatattt tgatatgaac ggcatctggc tagcgcttaa tgaagaacca gacatcccga 1668421 gaaatgacat taagctttct tatacccata ttgcttttac aattgaagat catgaatttg 1668481 aggagatgtc agctaaatta aaaagacttc atgtcaatat tctgcctggc agagaacgag 1668541 atgaacgcga tcgaaaatca atttatttta ccgaccctga cggccacaaa tttgaatttc 1668601 ataccggaac ccttcaagac aggcttcgat attacaaaca agaaaaaacg catatgcact 1668661 tttatgatga aacggccttt tgatagcaca accatatttc atataaggtt aaatttaaag 1668721 aagggtgttg gtggagactt tatgtttggg gaaggtttct acccgacttg ttcaacgatg 1668781 ccatatcttt tgaactgcac aagtgattgg gtgaaggtga aattgaaata cacattacat 1668841 tacattttat atgaagaaag cgagctgttt tatcaaatgt tgaactaatt aaactatgta 1668901 ctaaattttc agtatatttc aattgctttg ccccttaata aatataaaac cgcatccttc 1668961 cacgacctaa aaaatgaaac gtttttaaga agatggcgtc taatattcta aatgttcata 1669021 ttttgataaa agtttcctaa aggaaagaaa atttcttgac ttcaacaatc ttttggtgga 1669081 taattatggt gtaaacatga tgttcttttt cctcctattc gggctcgcac ccaaaagtca 1669141 gggcgagcct gctttttttg aacaacaaac cccctctccg taaaggaaga gggggttatt 1669201 ttatgcatct gatagatcaa tagattaatg gacggttctg aacacgccaa tcactttccc 1669261 tagaatgctg acattctgca aaatgatagg ttccatcgtt gggttctcag gctgcaagcg 1669321 aatgtgggta tcctctttat agaatcgttt tacagttgct tcatcatctt ctgtcatcgc 1669381 aactacaatt tccccattgt tcgctgtgtt ttgctgttta acgatgacat agtccttatc 1669441 gagaatacca gcatctatca tactgtctcc cataatctcc agcataaata catgctcgtc 1669501 tggaggaacc atgcggtcag ggagcggaaa atattcttca atattttcta ctgctgtaat 1669561 aggagatccc gccgtgactt tcccgatgac cggtacatta acgacctggc tttgcggaat 1669621 gtctacttct tcatcaagaa tttctattgc tcttggtttt gtcggatctc gtctgatcag 1669681 cccttttgtt tccaaacggg ccaaatggcc gtggacagta gaactggacg caagcccgac 1669741 agcctctccg atctctctca cggaaggcgg atatcctttt gatttaacct ctgctttaat 1669801 aaaacggagg atatcaagtt gcctttttga tagcttcgtc atttttcgca cctcaaaacg 1669861 tcgattttaa gaagattata gcatgatttt ccttacagta caaacatagg ttcgaaaaaa 1669921 caattgacag aaacgtttgt tcgtatatac tgaaattata aaaatgcgaa caaacattcc 1669981 tgttggaggt tatgatcatg agtaaagaat ctattatttt tgtcggtctg tttacagtga 1670041 ttttgagcgc ggttatcctt atgctgtcat atacaagcag cggccaagag cttaatcagt 1670101 atgttaaaat agaagtccag caaggcgaca cactctggtc aattgctgat caggtagccg 1670161 atacaaaaaa gataaacaaa aatgatttta ttgaatgggt agctgataaa aatcaacttc 1670221 aaacctctga tatccagccg ggtgatgagt tagtgatccc attgaaaaag aagcatcagg 1670281 atgcatatga attagcaact gtaagataga gaggaaagag agataaaatg aaagcactca 1670341 tttatgcccg tgtaagcaca aataaagaac agcaggaaac gtcattaaag cggcaggagg 1670401 aggagcttac ggccattgca gcggagaacg gcatggaagt ggtcaaagtg atttcagaaa 1670461 aagccagcgg atatgaaatg gatcgggatg gtgtatttga gctgctcgat gagattaaga 1670521 acgctgatat tgatgtcatt ttggttcagg atgagacaag gctcggacgg ggaaacgcaa 1670581 aaatcgcact gcttcattgt atttatagag aaggtgtgaa agtctataca acggctcata 1670641 gaggtgaact ggagttatcg gaggctgact caatggtctt ggaaatcgtc agcattgtgg 1670701 aagagtatca gcgaaagatt cacaacatga aaatcagacg gggaatgaaa cgtgcagtaa 1670761 aaaacggttt taaaccgcaa aaaaacttaa aaaaccaaca tgggaacagt ggaaaagaaa 1670821 aaatagaggt gccaatctca gagatcgtcc gcctgagagc gaataaactg acgtttgctg 1670881 aaatcgcggc taccctaaga gggtttggct atgatgtctc taaagcaacc gttcaccggc 1670941 gttttcagga atacatagag aatgaagaga ctgcagagtg aatcagttgt aaaacttttt 1671001 ttgatctagt actatataga caaaatgcaa taaaggagtt taacatgatt tcaaacgcga 1671061 aaattgccag aattaatgaa cttgctgcca aagctaaagc tggcgttatt acagaagaag 1671121 aaaaagccga acagcaaaag ctccgtcaag agtacttgaa aggttttcgt tcttctatga 1671181 agaacacgtt aaaaagtgtg aaaatcattg acccagaagg caatgatgtt acaccagaaa 1671241 agctaaaaag agaacaaaga aataacaaac ttcactaata taagaggaat acggcaatat 1671301 cgtattcctc ttttgcatat actataatca aaactcttat gtgacaaaat tcaacaagtt 1671361 tctctcaaat ttaagctgaa acagttgaga aaaagtcgtc agacatttat gatgtaaggg 1671421 tacaacacat aaggaagggg atttttatgg atacaattga aaagaaatca gttgctacca 1671481 ttcgcacact gtcaatagac gctattgaaa aagcaaattc tggtcaccca gggatgccga 1671541 tgggagccgc tccaatggca tacacgctgt ggacaaaatt tatgaacgta agtccggcaa 1671601 accctggctg gtttaaccgt gaccgttttg ttttatctgc tggacacggg tcagcactat 1671661 tatacagcat gcttcattta agcgggtttg atcttagtat tgaagatctt aagggattcc 1671721 gccagtgggg cagcaaaaca ccaggacatc cggaattcgg acatactgcc ggtgttgatg 1671781 ctacaacagg tccgcttggc caaggaattg ccatggcagt cggtatggca attgctgaac 1671841 gccatttagc ggaaacatac aaccgcgatt catttaacgt agtcgatcat tatacataca 1671901 gtatttgcgg tgatggtgat ttaatggaag gtatttcttc tgaagccgct tcactcgcag 1671961 gccatcttca gcttggccgt ctgatcgtac tatacgattc taatgacatc tctcttgatg 1672021 gagacctcga ccgttcattc tctgaaaacg tgaaacagcg ttttgaagca atgaattggg 1672081 aagttcttta tgttgaggat ggaaacaata ttgaagaatt aacagcggct atcgaaaaag 1672141 cacgccaaaa tgaaaagaaa cctacattaa ttgaagtgaa aacgacaatc ggattcggtt 1672201 cacctaaccg tgccggtaca tccggtgttc acggtgcgcc gcttggtaaa gaagaaagca 1672261 aattaacaaa agaagcttac gcgtggacat atgaagaaga cttctacgtt ccgtcagaag 1672321 tttatgagca tttcgctgta gctgttaaag aatcaggtga gaaaaaagaa caagaatgga 1672381 atgctcaatt cgctaaatat aaagaagttt atcctgaact tgctgaacag cttgaactgg 1672441 caatcaaagg agagcttccg aaggactggg atcaagaggt tcctgtgtat gaaaaaggaa 1672501 gcagtttggc atcccgtgca tcttccggtg aagttctcaa cggacttgcg aaaaaaattc 1672561 ctttctttgt cggaggttct gctgacctag cgggatcgaa caaaacgact attaaaaatg 1672621 ccggtgattt tacagcggtt gattactcag gcaaaaactt ctggtttggt gtacgtgaat 1672681 ttgcgatggg tgcggcctta aacggtatgg cgcttcatgg cggtcttcgt gtattcggcg 1672741 gaactttctt tgtcttctct gattacctgc gtcctgcgat tcgccttgca gcgttaatgg 1672801 gccttcctgt gacatatgtc ttcacacatg acagtattgc ggttggtgaa gacggtccga 1672861 cgcacgagcc tgttgaacag cttgcttcac tccgtgcgat gcctaacctt tctttgatcc 1672921 gtccagcaga cggcaatgag acagcagcag catggaagct tgcagtgcaa agcactgacc 1672981 acccaacagc gctagtgctt acacgtcaaa accttcctac catcgatcaa acatctgaag 1673041 aagcattggc aggagtagaa aaaggtgcat atgtcgtttc taaatctaaa aacgaaacac 1673101 ctgacgctct tctcatcgct tccggatcag aggtaggtct tgcaattgaa gcgcaggctg 1673161 aattggcaaa agaaaatatc gatgtttctg ttgtcagcat gccttcaatg gaccgttttg 1673221 agaaacaatc tgatgaatac aaaaacgaag tccttcctgc agatgtgaaa aaacgtcttg 1673281 caattgaaat gggctcatca tttggatggg gcaaatacac ggggcttgaa ggtgacgttc 1673341 tcggcataga ccgattcggt gcatctgctc ctggtgaaac catcattaac gaatacggct 1673401 tctcagttcc gaacgtagtg aatcgagtta aggcattaat caataagtaa gcttttgaaa 1673461 gaggatgagt caaatcatcc tctttttctt gtttatccga caaaaatagt attggctgtt 1673521 taacagtaat agacaattct ttcttttctt cttttgtata atagagagca aatgaaatgc 1673581 tgctggaaaa ggggatgaaa agatggaacg tcactactat acgtacctga tcaaagagga 1673641 atttgccaat cactatttcg gccgggaatc ggttatgttt gagctgtttc aagactatca 1673701 ttggacaagc cttgaaaagc agcagtatga aatgacagag aaacagattc aatatattac 1673761 acaaccaatc ccgattttac atatgcatca gcggttaaaa atgaatttaa acaagacgga 1673821 ttacaggcag ctggattata tttatagaat agctttgccg aaagcaaaag gccacgcgac 1673881 gtttatgatg aaggagcaca tgatagaaat tgtggcttcg ggagattacg aggcagaaac 1673941 gatattcttt gaagtgttaa gaaaagtaag cccttgcttt ttagcaatgg atttcaattc 1674001 gaagcgttac ggatggctaa atccggtgaa agaaagaaat tttgtctaaa accgaagaaa 1674061 aagagatgta aatgttgtat aatagctttt ggtttagtac actttaaact agacaacatg 1674121 aaggaggaaa taaaatgact ttatgggttg gcatcctagt gggcgttgtt gcattgctca 1674181 taggtgttgc actcgggttt tttattgctc gtaaatatat gatgagctac ctgaaaaaga 1674241 atccgcctat taatgaacaa atgttacgca tgatgatgat gcaaatggga atgaaacctt 1674301 ctcaaaagaa aatcaatcaa atgatgaaag ccatgaataa tcaaacgaaa taatacgtaa 1674361 agattatgat atagagaaac atggttataa aataaaaaac ccttatacgg gttttttatt 1674421 ttgcaatcat tcatcacccg ctactgctcg aaggcgctgc ttttgatatt gtatgagaag 1674481 atggtcaagc tcctgactga gctctatcgt aatatgagat gtcattccgt tcgccatgac 1674541 aatttgcagc agctctgctc tttttttttc aatttctttt aatagatgct ctctaatcac 1674601 agggatgtat cctttcatac attagatctt caaagtgaat gtttatatta tatccatatt 1674661 tatactaatt ttcaaatgag aaggagtata atgtctcaat gtcaaattaa attatataag 1674721 ttttttctga aaatagaaat ccttcaagtg aaagtgttaa aaaaatgaaa tgattttgtc 1674781 ataacttgaa ggaatgtcaa atcatgaagg gatgatgaca tgggagacgt gaattatttt 1674841 ttgacattcg gagcggggtt tttatccttt atttcgcctt gctgcctgcc gctttaccca 1674901 gcttttttgt catatattac aggggtcagc atggacgatg taaaaactga aaagctgctg 1674961 ctgcagaaaa gaagcttgtt tcatactttg tgttttttgc ttggcttttc agtcattttt 1675021 attgctttag gctatggaac atcttttatt ggcagcctgt ttagggatta tcacgatgcg 1675081 attcggcaaa ttggcgcgtt gcttattatt ttgttcggtt tcattacact cggtgtgttc 1675141 cggcctgagg ctatgatgaa agagcggaga atccatttta agcataaacc aagcgggttt 1675201 ttagggtcgg tcttaatcgg aatggcattt gcagctggat ggacaccatg taccggtccg 1675261 atattagctg ctgttatcac acttgcaggc accaatccgg gctcagcggt gccatacatg 1675321 atgttatatg tactcggttt tgcggtaccg tttcttttat tgtctttttt tatcacaaag 1675381 ctgaagtgga taaggaagaa ccagcttttc attatgaaag ctggtggcgt tttgatgatt 1675441 gtgattggtg tgctgttatt ctttaattgg atgagcctga tcattatttt gctgtcagat 1675501 ctttttggag gctttactgg tttttgacgg taaattactt tcgtactact actaatcctt 1675561 ttgtttttgg tacaataaga ctattatctg tggaaatcga ttgttggagg ggaatatgac 1675621 aagagtttta gttgtagacg acgccaagtt catgagagtg aaaatcagag agatcttgga 1675681 agaggcaaat tacataatcg caggcgaagc ggcggacggt gaacaagcag ctgacctgta 1675741 taaaaaactg cgcccggacc ttgtgacaat ggatattaca atgccggtga aaaacggcat 1675801 aaaagcgctt cgtgatatct taacctttga tcctaaagcg aaggtcatca tgtgcaccgc 1675861 catgcgccag caaagaattg taacggaagc aattgagctg ggggcaaagg attttattgt 1675921 taagccgttt gaggaaacaa aagtgctgga agctgtaagc cgcgttatgg gacattaaag 1675981 tcatttcttt tcaaaatggt tttttttatt gttttggagt atagtatata gtatcaacac 1676041 tccgagaaac aaaggaatga taagtatgat gattatagtt tcatcaatta ttgctgtgtt 1676101 aatggctgta gctgtgatgg tggtcagaat aaagtcctct gacaagcctg tttcaccaaa 1676161 aaaaatcatt cttccgccga tttttatgag tacgggagcg ttaatgtttt tatttccggt 1676221 attttgggta actggagcag agtttttgga agcattcact ttaggtgtga ttttctctat 1676281 ttttctaatc aaaacttcta agttcgaaat taaaaataat gaaatttaca tgaaacgctc 1676341 taaagcattt gtttttatat tagtcggtct tttggtgatc agaatcgtga tgaaatcgat 1676401 cttgagcaca tcaattgatt atggtgcact gagcggaatg ttttggattc tggctttcgg 1676461 tatgattgtg ccttggagaa tcgccatgta tttatcatat cgaaaacttc ataacgagct 1676521 gcagtcatct aatattcaaa tgaattaaaa aacctttcct cttgtcagga aaggtttttt 1676581 atttgagaag ggtctgataa ggttccaaat cgattttttt gtcccgcaga tgccttttta 1676641 agaaggtatg gtctctttta ggagttgcga gaatatagcc tttgatcata agttgctgat 1676701 caatctttgc taccttttct tttaatgcaa gctcaccgat tttgcctgcg attttagctt 1676761 ttgctgcatc tctgaacagc tctggcacgg gcgcagtcaa ttcatctaga aactgtttgt 1676821 tttcatcgtt ccataaatgt ctgctgtttt caatatagta atcctgccaa tcaagctctg 1676881 atctgccgtc ctcttttggt aaacgcttta aaaactttcg aaacatgaaa aaaccgccga 1676941 ttgataataa gactaccatc atgattaccc aaaacagaat aaaccataaa aaccatcctt 1677001 ccagcatcaa tcattccccc ttattctaac catattgtat acgaagagag attagaagaa 1677061 cacagtaaaa aaagaataga aaaaagtgat agacgtctag tcaaaagaga tagtagatca 1677121 tattctattg tatagtgaat ctgctatttg gccatgggag agtcactaga gggtatttga 1677181 cgataaatgg acggaaaaaa agtcactttc ataatagggg atgaaagtga ctttttatgt 1677241 ttagctgaga ggaaattgaa gagaaaaaga agagccatct tctgtttctt tattgacggc 1677301 gactgtgagt atttgatttt cgcattcgac ttgaatgttt ttgtcattaa aataaaaagg 1677361 aagcatcatt tgtttttcaa aagtctgtcc tgacgatttg acagttaaga tgaactcgca 1677421 tccagaaagg gtaactgtta cttgtgtagg ctgtaaaaaa gtcagatccg cttctataat 1677481 atactgctga cttgtttcat ataaatcaat aggcaatgtt tcgtcgtacc aggcgaaggg 1677541 gtcttcaaaa aattgccgaa gccattcatc catactatcg aaatcattcg catcgttgcg 1677601 ttttgaatgg ttcatggaag cattcctcca catatcaacc ttgctttaca tcatatgcgg 1677661 tggattataa atgggtgaac gcataaaaaa acagacacta aggtctgctt ttcttacata 1677721 tcatggcttg agttgtgctt ttgtcttgta tggtttcggt tttttacttt tttgcttccg 1677781 cttagaggct cgggttggcc gggattgtgt cctttagggg cgtttttatg catatcttta 1677841 cttgtattct tattggtcat aaaatgagaa cctccttaaa agagttcggt gttattgatt 1677901 ggtttttctt tttttgttat tttggcgttc tgcttcagtc agtacaagct ggtcgttttc 1677961 aatatagccg gcgcctttgc cttggctttt tgcgtcattc attccgttaa tgacgtgatt 1678021 cgcttttctt ttgaccatca ttatcacctc aatcataata tggcttcttt tattgtgtta 1678081 tatgagagag cgtaaacagt aaaaattacc ggtacatttt tctcataagt cgaacttatt 1678141 gtatttaata aaaacattga tatttactta tgtatgattt tgttttaata tgaaattgtg 1678201 agaaaattgt gatggaatgt aatgttcatc tgagaatgat ctgatctgaa gggggatttt 1678261 ggagaatggc aaacgagcaa aaaactgcag caaaagacgt tttccaagcg agaaaaacgt 1678321 ttactacaaa tgggaaaaca tatcattact actctttaaa agcgttagaa gattcaggta 1678381 taggaaaggt ttcgaagctt ccttattcca tcaaagttct tttagaatca gtattgcgtc 1678441 aagttgacgg cttcgttatc aaaaaagaac acgtggaaaa tttggcaaaa tggggaactg 1678501 ccgaattaaa ggatatcgac gttccgttca aaccgtctcg tgttatttta caagacttca 1678561 caggggttcc ggcagtagta gatctggctt cactgcgtaa agcaatggca gctgtcggcg 1678621 gagatcctga taaaatcaac cctgaaattc ctgttgatct cgttatcgat cactctgtac 1678681 aggtagataa agcgggtaca gaagatgcat tagcagtaaa tatggacttg gaattcgaaa 1678741 gaaatgcaga gcgctacaaa tttttaagct gggcaaagaa agcgtttaac aattatcagg 1678801 cagtaccgcc tgcaacaggt attgtgcacc aggtcaacct tgagttcttg gcaagtgttg 1678861 tccatgccat tgaagaagac ggcgagcttg taacgtatcc tgatacgctt gtcggaacag 1678921 actcacacac aacaatgatt aacggtatcg gtgttctcgg ctggggtgtc ggtggaattg 1678981 aagctgaagc gggaatgctt ggacagcctt cttacttccc agttccagag gtaatcggcg 1679041 cgaaacttgt cggcaagctt ccaaacggaa caacagctac tgacttggcg ttaaaagtaa 1679101 cacaagtgct gcgtgaaaaa ggcgttgtcg gtaaatttgt tgaattcttc ggaccgggaa 1679161 ttgctgaact gccgcttgca gatcgcgcaa caattgcgaa tatggctccg gaatacggtg 1679221 ctacatgcgg attcttccca gtagatgaag aagcgcttaa ctacctgcgc ctgactggcc 1679281 gtgatcctga acatattgat gttgttgaag catactgcag aagcaatggc ttgttctaca 1679341 ctccagatgc ggaagaccct caatttactg atgtggttga aattgacctg tctcaaattg 1679401 aagcaaactt atcgggtcca aagcgtcctc aggatttgat cccgctatct gctatgcagg 1679461 aaacgtttaa aaagcaatta gtcagccctg caggtaacca aggattcggt ttaaatgctg 1679521 aggaagaaaa taaagaaatt aagtttaaac tccttaacgg cgaagaaaca gttatgaaaa 1679581 cgggtgcgat cgccattgct gcgattacaa gctgtacaaa tacatcaaac ccatacgtgc 1679641 tgatcggcgc cggactggta gcgaaaaaag cggttgagtt agggcttaag gtgcctaatt 1679701 acgtgaaaac gtcacttgca ccgggttcta aagttgttac aggatatctt gtgaattcag 1679761 gccttcttcc atacatgaaa gagcttggct ttaacctcgt tgggtacggc tgtacaacat 1679821 gtatcgggaa ctcaggtccg ctttcaccgg aaatcgaaga agcggttgcg aaaaatgatc 1679881 ttctgattac gtctgtcctt tccggaaacc gtaactttga aggacgtatt cacccgcttg 1679941 ttaaaggcaa ctatcttgct tcaccgccgc ttgttgtggc atatgcgctg gctggaacgg 1680001 taaacattaa cttaaaaacc gatccaatcg gtgtgggcaa ggatggtcaa aacgtatact 1680061 ttaatgatat ttggccgtca atggacgaaa tcaatgcact tgttaagcaa actgttacgc 1680121 cagagctatt ccgcaaagag tatgaaacag tatttgatga caacaagcgc tggaacgaaa 1680181 ttgaaacaac agatgaagct ttatataaat gggataacga ttcaacttac atccaaaacc 1680241 caccattctt tgaagagatg tctgttgagc caggcaaggt tgagccatta aaaggactgc 1680301 gtgttgtcgg taaattcggc gattcagtca caactgacca tatttctcct gcgggggcaa 1680361 tcggaaaaga tacgcctgcc ggaaagtatt tgcaagaaaa aggtgtttca cctcgtgact 1680421 ttaactccta cggctcccgc cgtggaaacc atgaagtcat gatgagagga acatttgcca 1680481 acattcgcat caaaaaccaa atcgcaccgg gtacagaagg cggatttacg acgtactggc 1680541 cgactggtga agtaacatcc atctatgatg catgcatgaa atacaaagaa gataaaaccg 1680601 gtcttgtcgt attagcagga aaagactatg gtatgggatc ttcacgtgac tgggctgcaa 1680661 aaggaacaaa ccttctcggc atcagaacgg tcattgcaga gagcttcgaa agaattcaca 1680721 gaagcaatct tgtattcatg ggtgtgctgc cgcttcagtt taaacaaggt gaaaatgcgg 1680781 atacactcgg cttaacgggt aaagaagtca tcgaggtaga tgttgatgaa acagttcgtc 1680841 ctcgtgacct tgtgactgta agagcaatca atgaagacgg caatgtaaca acttttgaag 1680901 cagtcgtccg ctttgatagt gaagttgaaa ttgattacta ccgccatggc ggcatccttc 1680961 aaatggtgct tcgtgaaaaa atgaagcagt cctgatgaat caataggaag agaaggcatt 1681021 tcgctttctc ttctttttat gacacaatgt gctgcggagg tggcatatgc tgaaaaaatg 1681081 gctcgcaggg atcctgctta tcatgctagt cggttatacg ggatggaatt tatatcaaac 1681141 atacagcaaa aaagaagtcg gaattcaaga ggggcaacaa gcacctgatt tttctttgaa 1681201 aacgctatca ggagagaaaa gctctttaca ggatgcaaaa ggcaaaaaag tgctgctcaa 1681261 tttttgggca acttggtgta agccgtgccg tcaggaaatg cctgcgatgg aaaagctgca 1681321 aaaagagtac gccgacaaac ttgcggttgt tgcggtaaat ttcacttcag ctgagaaaag 1681381 tgagaaacag gtccgagcgt ttgctgatac ttatgactta acgttcccca ttctgattga 1681441 taaaaaaggg atcaatgctg actataacgt gatgtcatat ccaacgacat atatcttaga 1681501 tgaaaaaggt gttatccaag acatacatgt tggcaccatg acaaaaaaag aaatggaaca 1681561 aaaactggat cttgattaga ttcagttttt tttatactca aatatgctta caagttttca 1681621 gaattggaaa aaataaaaga atatgcggag gtgagaagcg tgaagaagat gagaaaacgt 1681681 tcttttcatg agctcgtcat ggaaaacaaa aaagagctga tgaccaatac agagtattta 1681741 aatcagcttg aggaaaagct tgaacagcga tttaagcaaa aataaccttt aatttgtatt 1681801 catgtttacc cctccttttg agaaacctat ctgttgagga gggataaaca tgggaaacaa 1681861 caagaaaaac ggtcagcctc aatatgctcc aagccacttg ggtacaaagc ctgtaaaata 1681921 taaagccaat aaaggggaaa aaatgcatga tacttcagga cagcggccga ttatcatgca 1681981 gacaaaaggc gagtagcgaa aattcgagtt tatttctagg aggtacatcc gaatgacaaa 1682041 gaaccaaaat caatatcagc agcctaatcc tgatgatcgt tctgacaatg tggaaaaatt 1682101 gcaggatatg gttcaaaata caattgaaaa tatagaagaa gcagaagcat caatggagtt 1682161 tgcttcagga gaagataaac agcgtatcaa agaaaaaaat gcaaggcgcg aacagagcat 1682221 tgaagcgttt cgtaatgaaa tacaggacga atctgcagcg agacaaaacg gataccgttc 1682281 ttaaaaaacc agggaaacct ggtttttttc tttctgattt gattatggta aaatggggct 1682341 aaattgacgt taagggagca gagtaatctt gcatgtatca aaaaaagaaa tagaagtgcg 1682401 ttatgcagaa acagatcaaa tggggattgt ctatcacgca aattatcttg tgtggatgga 1682461 ggtcggcaga acggccttga ttaaggactt aggcttttta tatagtgata tggaaaaaaa 1682521 aggcgttctg tccccagtcg ttgatatcaa tatttcctat aaaaagccgc ttcattacgg 1682581 agaaaccgcg gttgtacata catggataga ggactataac ggatttaaaa ccgtctatgg 1682641 ttaccacatt tataatccgg ccggtgagct ttccatcaaa gccacctcat ctcatatttg 1682701 tgtggataaa gaaagcttta agccaattca attccgcaaa gcttttcctg attggcacac 1682761 agcatatgaa aaggccaaaa aatagggaag tgaacgggat atggcgtttg gtgtgaaacg 1682821 ggaggaactt aaccggtgga aacaagcagt gaaaagagga gaaatcgcat ttttaacaca 1682881 ttactggctg gatgaccgat ttccagaagc aaagaccgtg acaaaagccg gctgtgcaga 1682941 cattgataag ctggttcagt ggggagcggc gtacgggtta aaaaaagaat ggatccataa 1683001 gaaaagtgaa tttccccact ttgatctgct gggggaaaca caaaaatata ttttggaaca 1683061 agaaaaccta accgatcatc ttatacgatt tcatttgtaa aaaaagaacg cacatgaagt 1683121 gcgttctttt ttattggtat tcaaaaaccg gttcatcagc gtcttctgaa tagctgacga 1683181 gaaggtcgtg gttatcaaag taccataaat cactttcttc aataaagaag gtaatgccat 1683241 cagcttctgc agtgactcca gcctcttgtg gggcatcttt cgctacaccg agagaaaaac 1683301 ccttttgaac gttgctgcag cctccatagc ggacgaaaaa gcgaacctgg tctccgcttt 1683361 ccaaatcgag ttcttcttta taccagttca atgcgtcttc gttaattgtc atattcataa 1683421 cagaacaccc ctttgttctt catttgaatt ttctctatta taaacgtatt aggctattct 1683481 gtgtcaaaag agaagttttt taagcttata accattttac tttaggttct gttttattga 1683541 taattcgttt aatgttcgct cggtgtctgt atatcacaaa aatagtgagc agggtaacga 1683601 caatcaataa atacgtatca tggacaaaga aactatatat aacagtatag atccctgtta 1683661 acatcgatga gagagaaaca aatttagtca agtataaaaa gatgaagaat accgcaacca 1683721 tcgtgataaa taacaggggt gcgtaaaata gcaaaacgcc tcctgatgtc gccacggctt 1683781 taccgccttt aaatttggcg aagatgggaa acacgtggcc taaaaccgca aagactcctg 1683841 caagaagcgg gtgaatatca acatgcatga gaaaaggcaa tgcagttgcc agtgtccctt 1683901 tcaaaatatc tccggctatg acgaccgaac cagcttttac acccaatgta cggaatgcat 1683961 tggtagcgcc taagttgccg cttccgtgct cccgaatatc aattcctttg gcaagcttgc 1684021 ccacaattaa gccagatgga atgctgccta tcaagtaggc caaaataatc aataaagcaa 1684081 ttaacatcta catttctcct ttttcaaatt cccttctttt tattttaaca tgagatgtca 1684141 tgatctgatg ataagttttt ttgtaaagtt tgcttacaaa tcaaatcaaa catgcatcat 1684201 attttgattt ctcctgtttt gatcgtgtaa aataagtgaa aaaggagtga cacacgatgc 1684261 aaaacccttc taaagcggaa attaaagaga ttcttcaaag aagcaaacgt atagcggtag 1684321 tagggctttc agaccgtccg gatagaacgt cacatatggt ttcaaaagca atgcaggacg 1684381 cgggttatga aattatccct gtgaacccta caattgatga ggcgctaggt gtcaaagccg 1684441 tttcatcttt aaaagagata gacggtccga ttgacatcgt aaatgtattc cggcgctcag 1684501 aacagcttcc tggagtggcg gaagagtttt tagagacaga tgcgccagta ttttgggcac 1684561 agcaagggct agttaatgag gaagcatacc agatgctaaa agaaaaaggc agaacggtta 1684621 tcatggatct gtgcataaaa gtggcacacg ctgtaacaaa ataggtgcag aactgcaaaa 1684681 atccttgtaa attcaaggat ttttgctttt taattttaag atattgtttg cgtattacgg 1684741 tgaaacagat acaataaagc ttgaacagct ttttttgaat accttgtcca gctgggtttc 1684801 ggccgttcga tttgcgaagg tctgctgctt tatatataat aaacaaacat acgttctcat 1684861 agtgtaaaaa cagcactagc cgatgttttg agaagaactg attcgttagc tctatgttgc 1684921 gattgcaaac atattggtta taatgaggag tccaaggcag tactggctcg aggcgaggtt 1684981 tataaaaaat atcttatata caaatgatgt gtaacactga aaagagaaag acaatgttag 1685041 tttttgaaag gggtttgtac gtttggctag aaaacagcaa tttgattaca acgaagatgc 1685101 catacaggtg ctcgaaggcc ttgaggctgt caggaaaagg ccgggtatgt atattggctc 1685161 tactgacgcg cggggtttgc accacttggt ttatgaaatt gtagataact ctgtcgacga 1685221 ggtgcttgcc ggccatggag atcacataat cgtcaaaata cataaagaca atagtatttc 1685281 tgtacaggat agaggccgcg gcatgccgac cggaatgcat aagctcggca aaccaacccc 1685341 tgaagtgatt ttaacggtgc ttcatgccgg agggaaattc ggccaaggcg gctataagac 1685401 aagcggcggg ctccacggag ttggtgcatc agtcgtgaat gctttatctg aatggctgac 1685461 ggttaccatt gagcgggacg gttttgtcta tcagcagcga tttgaaaatg gaggaaaacc 1685521 ggttacatct ctcgaaaaga tcggcaaaac aaaaaagacg ggaactctta cacactttaa 1685581 gccagatcca acgatgttca gcacaaccac ttataatttt gaaacgctct ctgagcgctt 1685641 aagagagtct gcgtttttgt taaaaggact gaaaattgag ctgattgatg aacgcaatga 1685701 ccagcgtgag gtcttttatt atgaaaacgg catagaagcg tttgttgctt acttaaatga 1685761 agaaaaagac gtcttgtctg aagtggtctc gtttgagggt gagcatcatt ctatagaagt 1685821 ggactttgcg ttccagttta acgatggtta ttctgaaaat attttgtcgt ttgtcaacaa 1685881 tgtcagaaca aaagacggcg ggacgcatga gtcaggtgca aaaactgcga tgacgcgtgc 1685941 ttttaatgaa tatgcgcgaa aagtggcttt gctgaaagaa aaggataaga accttgaagg 1686001 caccgatata agggaagggc tttcagccat tatttctgtc cgcattcctg aggagcttct 1686061 tcaatttgag ggacaaacaa aaggaaagct cggtaccagt gaagcaagat cagcggtgga 1686121 tgcgattgtt tcagagcagc ttgcttactt tttagaggaa aatcgggaca ccgcaacgct 1686181 tcttgtcaaa aaagcaatca aggcgagcca ggcgcgcgaa gcggcacgca aagcccgtga 1686241 agaagcaaga agcggcaaaa aacgaaaaaa atcagaagcg actttaagcg gaaagctgac 1686301 gcctgcgggt tcaagaaacc cggcaaaaaa tgaattgtat ctcgttgagg gagattcagc 1686361 aggcgggtca gccaagcagg gacgagaccg cagattccag gcggttctgc ctttacgcgg 1686421 taaagtcatt aatacagaaa aagctaagct tgctgatatc tttaaaaatg aagagatcaa 1686481 tacgatcatt catgcgatcg gcgggggagt cggggcagat ttctcaatcg atgacatcaa 1686541 ctacgacaaa atcatcatta tgaccgatgc cgatactgac ggcgcccata ttcaagtgct 1686601 gcttcttacc tttttctatc gctatatgaa accgctcatt gagcatggca aggtgttcat 1686661 tgcgctgcca cctttatata aggtcagtaa aggaagcggg aaaaaggaaa tcattgaata 1686721 tgcatggtct gatgaagaga tgggggatgt cctgaaaaaa gtcggcaaag gctataccat 1686781 tcaacgatat aagggtcttg gagagatgaa cgcagaccag ctgtgggaaa cgacgatgaa 1686841 tccggagtcc cgcacacttg ttagggtcaa aattgacgat gcggcacgtg tagagagacg 1686901 tgtgacgacg ttaatgggag acaaagtaga gccgcgcaga aagtggattg agaaaaacgt 1686961 cgctttcggc ttagatgaag aaagcaatat tttagaaaat gaaaacttat cggtcgctga 1687021 ggaggtttaa tgattgtcac agccagaatt atttcatgat ttaccattag aagaggtgat 1687081 cggcgaccgt tttggacgct acagtaaata tattattcaa gacagggcgc tgcccgatgc 1687141 gagagacgga ttaaagccgg tacagcgcag aattctgtat gcaatgcata cagatggaaa 1687201 cacgtttgat aaaaacttca gaaaagcggc caaaacggtc ggtaacgtca tcggtaacta 1687261 tcatccgcac ggtgacagct cggtttatga agcaatggtg cggatgagcc aggattggaa 1687321 agttcgtaat gtgttaatcg aaatgcatgg aaacaatgga agcatcgacg gagatccccc 1687381 ggcagccatg cgttatacag aggcacgatt atctccgata gcatctgagc ttcttcggga 1687441 tattgacaaa aacacggttg aatttgtgcc gaacttcgat gatacaagca aggagcctgt 1687501 cgtactcccg gcgatgtttc ctaacctatt ggtcaacgga tctaccggga tttcagcagg 1687561 atacgcgacc gacattcccc ctcatcatct gggagaagtc attgatgctg tcattaagcg 1687621 tattcaaatg ccttcttgct ctgttgacga actcatggaa gttattaaag ggcctgattt 1687681 tccgacaggc ggtattattc agggcgttga cgggataaga aaagcttacg aaaccggaaa 1687741 aggaaaaatc attatccgcg gaaaggctga aattgaaaca atcagaggcg gacgagaaca 1687801 aattgtcatt actgaaattc catttgaagt aaataaagca aaccttgtaa aaaaaatgga 1687861 cgagttccgt attgataaaa aggttgaagg catctcagag gttcgtgatg aaacggatcg 1687921 aacagggctg agagtggtca ttgaactgaa aaaagaagct gatgccaaag gcattttgaa 1687981 tttcttatat aaaaatactg atttgcagat cacatataac ttcaatatgg tggctatcca 1688041 taaccgccgt ccgatgctga tgagcctgcc gtctattttg gatgcatata tcggacacca 1688101 aaaggaagtt gtcacaaacc ggtccgttta cgagcttcaa aaagcaaaag acagacatca 1688161 tatcgtagaa gggctcatga aagctttgtc tattttggat gaagtgattg caacaatccg 1688221 ttcttctagc gataaacgtg acgctaaaaa caatttgatc gcgaaatatg aatttacaga 1688281 gcctcaggct gaagccatcg tgtcattgca gctatatcgt ttaaccaata ccgatatcac 1688341 agcgcttaag gaagaggcag aagagctcgg taaaaaaatt gaagagctcg aatctattct 1688401 gagcaatgat aaaaaactgc taaaagtgat tacaaacagc ttaaaagcac tgaaaaagaa 1688461 atatgcagat acgagacgct ccgtgattga agaaaaaatt gaagaaatta aaatcaatct 1688521 cgaagtcatg gttgcatctg aggatgtata tgtaaccgtt acgaaggatg gttacctaaa 1688581 acggacgagc cagcgctcat ttgccgcttc caacggtcag gacttcggaa tgaaagatac 1688641 ggacaggatg ctgcatcagt ttgaaatgaa tacgacagac gtgctgctgc tctttacgaa 1688701 caaaggaagc tacatctatt gtcctgttca ccagctgcct gatatcagat ggaaggacat 1688761 gggccagcat ttttcaaatc taatcactat tgaccgtgat gaaacgattg taaaggctat 1688821 accgataaaa gaatttgatc cgtcggcata tcttctattc tttacgaaaa acggtatggt 1688881 gaaaaagaca gagctcactc attataaagc acagcgttat tctaaggcac ttgtagcctt 1688941 aaatctgaag ggtgaagatg aactgattga tgtacatgta acaaatgggg aaagccagat 1689001 ctttatggcc actcacttag ggtatggtct atggtttgga gaagacgaag tgaatgtagt 1689061 tggcgcgcgt gcggcaggtg tcaaagggat taacttaaaa gaggatgact ttgttgtctc 1689121 cggtgagatt cttcagcaat ctgattcaat tgtcttgttc acacagcggg gagcggttaa 1689181 acgcatgagt ctttctgagt tcgagaagac atcccgtgca aaacgcggtg tcgtaatgct 1689241 aagggaactg aaaaagaatc ctcaccgtgt tgtagcactg ttcgcttgcg gtcttgaaca 1689301 gcgactaatg gcagaaacag aaaaaggcga cagaaaagaa ctgcagacaa aagagttgcg 1689361 gacaaacgac agatacagca atggctcttt cttttttgat gaagaggaat caggcaaggt 1689421 tacagctgtt tggcgccttc atacagaaca ataataaaaa acccgctcat actatatgag 1689481 cgggtttcgt ttgtttttta tcagctttca tggttggtga atagatctgt tacagcatga 1689541 atgacttcaa tcccctgcca tacaaataaa ttcagcgctg tgaaagaaaa taagcctaaa 1689601 atcaccattc ttaagataaa caacatgttt aacagcctcc tcatattttc gttacataat 1689661 cgggtgatgt tgaacatgaa gtttgccgaa ataagacgat tgataaaatt tggccagtat 1689721 aaagcttttt ttccgctgac gtctgcggga gtatcccgta cttttgcttt cagcggtcag 1689781 cagcagaaca gccattgccc ataaagcggt cagcgtaaat gcccctgtga tggatttctt 1689841 ctcatcatca gcattttggc cggctttcat ctcatgcatt tcctgctggt cggctacggc 1689901 tttataatga tggccgatat caaaggcgtg gggaattgag aacaaatgaa aactggcaat 1689961 cgccaagaat aagatggatg ctttcaatat cgttactttt ttcaaatgat ctccccctcc 1690021 tttaatatta ctgaatattt ttataataat accccaatcc atcctaaaag taaacctgat 1690081 ttattaaatt taaaaataaa tttaactttg ttaagtatat atctttttgc ttatttttga 1690141 aagagaaaac ttcttttatt agcgtatgta tacccggttt atggtgtgaa taaaaacata 1690201 ttttaaatga tatgttgttt aggatttatt actttattta tgtgtaaatc aaagagaaag 1690261 gcaagagaat gggaagaaat gattacattg ttaatagggt actctttttt taaagccagt 1690321 ttgcaaggaa tgtttttatt cgtaggaaaa taatagagaa ggggtcgaca gagtaacatc 1690381 tggctatgac aatattcttc tcgaaaaaac ttcctaattc gtcatattgt gatataataa 1690441 aactcgttat gttaaaaaat ctaacatcaa aatcgaattc gtattgaatt gatgaaaacg 1690501 ggaggtaaat atggagtctt ttttcaatag tttgattaat attccaagtg atttcatctg 1690561 gaaataccta ttttatattt taatagggct tggattattt tttaccatac gttttggttt 1690621 tatccaattc cgttatttta ttgaaatgtt cagaatagta ggggagaagc cggaaggaaa 1690681 taaaggtgtt tcatctatgc aggcattctt tatttcggcc gcatcccgag tcggcacagg 1690741 gaatttgact ggtgtagcct tagcaattgc gacaggcgga ccaggcgctg tattttggat 1690801 gtgggtagtg gctgcagtag gcatggcttc aagctttgtc gaaagtacat tagcacagct 1690861 ttataaggta agagacgggg aggatttccg cggagggccg gcctactata ttcaaaaggg 1690921 tcttggtgcc agatggcttg gcatcgtttt tgcaatctta attaccgtct cattcggctt 1690981 gatttttaac gctgttcaaa caaatacaat tgctggagca ttggatggcg cattccatgt 1691041 aaataaaata gttgtagcca tagttctggc ggttttaact gcgtttatca ttttcggcgg 1691101 tttaaaacgt gttgtcgctg tttcacagct aattgtgccg gttatggcag gcatttatat 1691161 tcttatcgct ttatttgttg tcatcacgaa tattacggct ttccctggcg ttatcgctac 1691221 aattgttaaa aatgctttag gttttgaaca agtcgtcggc ggcggaatag gcggcatcat 1691281 cgttatcggt gcgcaacgcg gacttttttc aaacgaagca ggaatgggga gcgcaccaaa 1691341 cgcggctgcg acggctcatg tatcccatcc ggcaaagcaa ggctttattc aaacattagg 1691401 cgtatttttc gatacattta tcatatgtac gtccacagca tttattattt tgctgtacag 1691461 tgtaacgcca aaaggcgacg gcatccaagt cacacaggct gctcttaacc atcacattgg 1691521 aggctgggcg ccgactttca tcgcagtcgc aatgttcttg tttgcattca gttcagttgt 1691581 cggcaactat tattatggcg agacaaacat tgaatttatt aaaacaagca aaacatggct 1691641 gaacatttac cgtatcgctg ttattgctat ggttgtgtat ggatctttat caggcttcca 1691701 aatcgtttgg gatatggcgg acctctttat gggtatcatg gcgctgatca acttaattgt 1691761 gattgcgctg ctgtcaaacg ttgcttacaa agtgtataaa gattacgcga aacagcgtaa 1691821 gcaaggactt gatcctgtgt ttaaagcgaa aaacatccca gggctgaaaa acgctgaaac 1691881 atgggaagat gagaaacaag aagcataata taaatataaa acaaagctgc attcaatagt 1691941 tgaatgcagc tttttcatta ttggaaataa atttaatttt tcgactcgaa tgaaaaatga 1692001 cgtgtaaagt cccaattcag tccagttttc tttgttctat atgtgtcatg tgtgtcttat 1692061 tcattggagg tagagcaaat tgacaggctt ttaaacctcc ccaaaacaag aaattaggtt 1692121 gatagacaat catgagaaag atttttacaa tgagttcgtg ctcataagaa gtgtagagcc 1692181 aaaatgatgc gaaggaggaa aagatcagat atgaaacggt caatctctat ttttattacg 1692241 tgtttattga ttacgttatt gacaatgggc ggcatgatag cttcgccggc atcagcagca 1692301 gggacaaaaa cgccagtagc caagaatggc cagcttagca taaaaggtac acagctcgtt 1692361 aaccgagacg gtaaagcggt acagctgaag gggatcagtt cacacggatt gcaatggtat 1692421 ggagaatatg tcaataaaga cagcttaaaa tggctgagag atgattgggg tatcaccgtt 1692481 ttccgtgcag cgatgtatac ggcagatggc ggttatattg acaacccgtc cgtgaaaaat 1692541 aaagtaaaag aagcggttga agcggcaaaa gagcttggga tatatgtcat cattgactgg 1692601 catatcttaa atgacggtaa tccaaaccaa aataaagaga aggcaaaaga attcttcaag 1692661 gaaatgtcaa gcctttacgg aaacacgcca aacgtcattt atgaaattgc aaacgaacca 1692721 aacggtgatg tgaactggaa gcgtgatatt aaaccatatg cggaagaagt gatttcagtt 1692781 atccgcaaaa atgatccaga caacatcatc attgtcggaa ccggtacatg gagccaggat 1692841 gtgaatgatg ctgccgatga ccagctaaaa gatgcaaacg ttatgtacgc acttcatttt 1692901 tatgccggca cacacggcca atttttacgg gataaagcaa actatgcact cagcaaagga 1692961 gcacctattt ttgtgacaga gtggggaaca agcgacgcgt ctggcaatgg cggtgtattc 1693021 cttgatcaat cgagggaatg gctgaaatat ctcgacagca agaccattag ctgggtgaac 1693081 tggaatcttt ctgataagca ggaatcatcc tcagctttaa agccgggggc atctaaaaca 1693141 ggcggctggc ggttgtcaga tttatctgct tcaggaacat tcgttagaga aaacattctc 1693201 ggcaccaaag attcgacgaa ggacattcct gaaacgccat caaaagataa acccacacag 1693261 gaaaatggta tttctgtaca gtacagagca ggggatggga gtatgaacag caaccaaatc 1693321 cgtccgcagc ttcaaataaa aaataacggc aataccacgg ttgatttaaa agatgtcact 1693381 gcccgttact ggtataaagc gaaaaacaaa ggccaaaact ttgactgtga ctacgcgcag 1693441 attggatgcg gcaatgtgac acacaagttt gtgacgttgc ataaaccaaa gcaaggtgca 1693501 gatacctatc tggaacttgg atttaaaaac ggaacgttgg caccgggagc aagcacaggg 1693561 aatattcagc tccgtcttca caatgatgac tggagcaatt atgcacaaag cggcgattat 1693621 tcctttttca aatcaaatac gtttaaaaca acgaaaaaaa tcacattata tgatcaagga 1693681 aaactgattt ggggaacaga accaaattag ttaagctttt ttttggcgga catcagtaac 1693741 gatgtccgtt tttatcatct aataggaggt ttgcgttgtg gatgaaatac tgaaacagta 1693801 tatggtgctg tataaaaaaa tgagtaatat gataaatggt cccgactatc caggtaagga 1693861 aaaagacatc cagcatcaaa aagatcagat cgaagtttac gaaaaacagc tgcagcaagg 1693921 attttctaca gattatgact atgatgtgtt tgctgattct gttatcaaat gcgcatatgg 1693981 cgatatgacg ctggaagatt tagaagccgt ttattatgga ttgacaacac catttttttg 1694041 atttgtcatt cagcagtaaa atttcaattt ctgtctcact aacttaagta tactttgata 1694101 ttgagacaga aatttattta ttttgtttac ttcctagaat atatattatg taaactagaa 1694161 aagatgaaga ataaagcttt gctgttttta tgtacatcct ttcttcttcc tgtaattcag 1694221 caacaaaata aaaaagcgat ttcccaatcg gaaaatcgcc aattcagaca ctctattatt 1694281 tatgtgtgtc tttgtgctct taacgattta caacaaatgt tgtcacgctt tgagctggaa 1694341 gatgagccca aaaatgattg cctgatacag tgagattcgt tccaggttgt agattgctgc 1694401 tgctgctcgt gatccatcta gatacgtttg aagcagatcc attctgcaaa acaaagtttt 1694461 ggttgactcc tgtgttgctt ttattgatgg caacaataac gaccttgttg tcacctttat 1694521 aggctgacac gtaaacgttc gcattagggt ttttcgttgc atcaatcctt acatagccgg 1694581 gacgcacaaa ctttgagaaa tgagccatat tgtagccgcg tttgctgatc gtaccatctt 1694641 ctttcatagg tccatatgat cttcggatgt accaccatac ataagcttga aagtccccct 1694701 ctaccatcgc attgtgaata tgctgtgaaa catccaatgc ctcaggccat cgatccgccg 1694761 agttggtatc actgtttgga tagtatactt ccgtcatcca aaggtccttc cccgctcctt 1694821 tttgtttgaa aagaggataa gggaattggc tgacctgggt gccgtacagg tgagttccga 1694881 gaatatccat attggcaaga gcctgcggat cgttcaagat cgggtccgac aaattcttca 1694941 agtattgaaa tgactcaggc gcaatgacgc gggcattgat cgagccggcg ttttctctca 1695001 taaagcgaag tatttcttgc ggcgtccacc acgtccactc gtgagcgtaa tcaggctcgt 1695061 tttggaccga aatcgcgtaa agattcacac cattattctt catgaaggta acaaaatcgt 1695121 taagatgctg cgcgtatgct gcgtacttgt tgtatttcag ccgtttagcc gatgtgtcac 1695181 cattccgatt aaaggtctca accatatcac ttggaggatt ccaaggagaa gcaaaaacga 1695241 ttgctccgtg tttgaccgca ctctttgcag tctccacctc tttataccaa ttatttcgat 1695301 tttcatctac atgaattctt aagattgaaa atcctaactg gttctgtcca ttgccaaaag 1695361 cagtttctct ttgagctgct gtaagatccc cagcccaagc cggatgattc atccctccaa 1695421 aaccgcgaat cacttgtttc tctgcagata cattaactgt tacatcactt gctgccaaaa 1695481 cttcagtagc gcctggccct aacatgactg acagcatagt gaaacatact aatagtacac 1695541 aaattgtttt ttttatgcgt ggaatcattt attcctctcc ttcgtcatgt gtcttttacg 1695601 gtattaaaaa atctgcatgg catatccata atggcgggct gttccggtgc tggcccgtac 1695661 ttcacccgcc tcgtttttaa gcggtcccat tacgagtact atctttgcgt aaactgccag 1695721 taatcaaaat taaacaagtt tcctgtacct gttccggtaa atacaaagaa tactttgtgc 1695781 acaccggttg ccccgcttac cgcagtttct atttccctcc acgtttgcgc tccgcctgtt 1695841 gaaggcacat tcagagttcc aacaagctta ccgtctgcac tgtcgaggcg cacttctatt 1695901 ttcccgccta aagtggatgc tacatttgct ttaaatgacc tggcaccgcc cgctccgaag 1695961 tctgcatttc ctacagcaat ccagtctcca ttttgaatgc ttgttacatg ctgattattt 1696021 actggcccgc cgggtgctgt ggacttctct gtcaaaatgc gtccattcca agcaaacgtt 1696081 tcagcttcta cccggttata tgggtttaaa ttggaaattt gtgttacacc tgcataattt 1696141 gccgctacct cttgaataga tccatctgca ttatgcacca gcttattaat atggggagag 1696201 cggtatcctt tgccggcccc gaacagagcg gaactgacag tttgcgcatg gtacaccaca 1696261 taccactcgt ttttaaaatt gaaaacagca tgatggttgt ttccgccacc tccgaaaaat 1696321 gcacccggat ttttcaggaa gtgccctcta tatgtaaagg gacccatggg acttgaactg 1696381 gtcatgtagc cgatctcacc cgggggttta tcggccgggt gcgtgccgcc gaaattgatg 1696441 caataggagt aataatatgt tccgttatac ttgtgcaatc ccgaatcttc aaacatgaaa 1696501 ggcgcatcaa ttgtagatgc acttccaaca acactcgtca tatcaggccc caattttatg 1696561 actctagccg ttttaggatt ggcccattgt ccctgcgttg gatttgaaac gccaggaacg 1696621 cctccgccgg catacaggta accggttccg tcgtcatcta caaatactgc cggatcaaaa 1696681 agccatacaa caccagacat tcctggcgta cttggcgtta cgagcggttt tccgattggg 1696741 tcggtccatg gaccaatcgg gctgtctgcg gtgagaaccc cgatacctcc gccgctgttt 1696801 gcgaaataaa ggaagaattt atccttgcca ttaatttttt taactgcgat tgacggtgcc 1696861 catgacgcac ctgcccattt tgcaattcca cggcctccat tagctccatt ggcacctgct 1696921 accggaatgg ctccgtggtc tgtccagttc accatatccg ctgaagatat gacgaatact 1696981 ctattcaaat tggcaaatga attatcttta attgttccgt tgctattata ttcatagtca 1697041 tcacttgaca tatagatgta gactcttccg ttataggtca gcgcaaccgg atccgctccc 1697101 aaatgatggt cgataagcgg atttgaattc cctatatgtt ttgcaattgt agtactagtg 1697161 gcagcatacg cagacttccc agataagcag ctcaataata aaactagaat ccataaacat 1697221 acgctacact ttttcctcat cacttcacat cctccttttt ccttaaaatg ggggattttc 1697281 ttttggaatt tgataacaac aggtcacgaa gattgcacgc ataaagtagc cggaagctgt 1697341 ttagcaatgt tcccagttgt tctgaaagct catcttcatg tgtctccatt ctctcttttc 1697401 ttcgaggaga tcgcaccact ccttcaaaat tgttcaaaaa aacttcccca ttcctagcga 1697461 ccattgtcca gaaaataaaa agacaggatt gttcatggcc tcccactaat cacattgaac 1697521 ggagattaca tcattatcca agatatccct ttatctaaca tcctacatca ttaaaaaaat 1697581 tgtgtataga aacttttgga ggagttagtg ttcgattcta caaaggaact ggatacattt 1697641 attcattgat aagatggggc taacactccg tttatatttg tatgttttca gacacaaaaa 1697701 acagccgttc aatgcggctg tttttttcaa gagtataaga ctattgagcg gtatacccgc 1697761 tttttcatgt tttgttcata ttttattaat tgtttattca acactgtccg ctatagtaat 1697821 ccatatcaac aaatatgact gccactcgca tcttttatga agggaggttc gttacgctga 1697881 aagaaaaaat aaagacatta ggccgttttt gcaccgtagg cgtcggcaat acgctgatag 1697941 attttggtgt cttctttctt cttaccgctt gtcatgtctc ttatctgccg gcgcagatct 1698001 gctcctatac tgcaggtatc gtcaacagct atgtgtggaa ccggaattgg acgttttgtg 1698061 tgaaacgtaa ggctgacggg aaagagatcg tgcgttttct catgattaat attgccgcgt 1698121 cagggatcac ctttttgctg ctttatttgt ttcaaaattg cggctgctcg cttttggtga 1698181 gtaagctcgc cgccactatc ggcggaatga tgatgaattt tatcggaaac cgaatctggg 1698241 tatttggaga ttcgctgaaa aacatacagg atcaggagtg aagatgaatg agaaaaaaag 1698301 tgagaaaagc ggttataccc gcagcgggtt taggaacgag atttctgccg gcgacaaagg 1698361 cgcagcctaa agaaatgctt ccaatcgtcg acaaaccagc aatccaatat attgtagaag 1698421 aggccgcaga gtcaggaatt gaagatatac tgattattac agggagaaac aaacgctcga 1698481 ttgaagatca ttttgatcgg tcggcggaat tggaattcaa tctccgggaa aaaggcaaga 1698541 cggagacact taaggaaatg cagcagattg ccgatttggc caacattcat tacatccgcc 1698601 agaaagaacc gctcggatta ggccatgcgg tgctgtgtgc ggagcatttt atcggagatg 1698661 agccttttgc tgttctctta ggtgatgata ttatggtgtc tgaaacaccg gctcttcggc 1698721 aattaatgga tgtatatgac gtttatggca cagaggttgt cggtgtacag tcagttctcc 1698781 ctgaggatgt cagcaaatat ggtattataa atacatcagg gtctcaaggg catgtatatg 1698841 aagtgaacga tttagtggaa aagccttctc ctgaagaagc accttcggaa atcgcagtaa 1698901 tgggacgtta tgtgctgaat tcttcgatct tctccgtttt gaagacaatt ggcagaggcg 1698961 cgggcaacga aattcagctg acagatgcgc ttcgtgaggt ttgccgtaag gagccgatcc 1699021 atgcccggct gctggaagga aatcgatatg acattggcga taagctgggc tgttttaaag 1699081 cgagcaccga aatcggctta atgcgtcccg aaatgagatc tcagcttttg gcctatttag 1699141 aagatgtgat caaacgggaa acgaaagaaa tgctgcggta aaaaaattgt aaccatcttg 1699201 ctcgtcaatc agtcatataa tagtgaaaaa gattaggaca ggttgtgaag aatgtgggca 1699261 gtttgataag cgaaatttta acatggctga cgaacatggg atatgcgggt attgcgattg 1699321 ggttaatgat tgaaatcatt ccgagtgaga ttgtattagc ttatggcggc tatatggtat 1699381 cggagggcac gattggattt attggcgcaa ttattgcggg tgttatcggg ggcaccattg 1699441 cccagatctt tatttactgg atcggtcgct atggcggcag gccatttctg gacaaatacg 1699501 ggaagtattt attgattaaa aagcatcata tcgatatgtc ggaaaactgg tttcagaaat 1699561 acggcgccgg agttgtcttc tcggctcgtt ttataccggt tgtcagacat gccatatcca 1699621 ttccggcagg tattgccaga atgccttttc tcaaatttgt ggtactgact gtgcttgcta 1699681 tcattccatg gtctatcctg tttgtttatt taggcataca gctaggaagc cagtgggatg 1699741 atgttgagaa tatagcaggc acttatacaa caccgattat gatattggct gttgtcgtga 1699801 tagcccttta ttttgtgatt aagaaacgta cagccatatt taaacgatag ctagcggata 1699861 tgcatagggg tgactgacgc tcccctatgc atattttttt acttgcgatg ttgatttgcc 1699921 agcttcagat tctccgctaa aaatgcgaca aacacttcat cccgcacgag cgatgcggca 1699981 taatttctct taataaacca ttctgcctct tcaaacgctg cgaatgtttc gtcttgggtt 1700041 tctccgttaa tttgaatatt ccattcgttg tctaaaggga aaagaaaaaa tctcatttgt 1700101 gcgcgatttt catataatga tccattcgca gatcccttta gattatagat gttacggaag 1700161 gcatccggcc gtacaggatc aatacggaaa gcttcagcta caaacaactc gtatacttca 1700221 tcggttattg aacagccgga cgcttttgca tgccctccgc cgccatatcg gccggcgatt 1700281 tctgacacat cgatgtaatc atgaatggtg cggagactga ctcgttttga ccccatgctc 1700341 aaaatcgcaa tgtaatcgag gtgcgggtta tctttcccta gcctgttccc cagctctgaa 1700401 tggtacgatt cagcgtgaac gatgcctaca cagtgttcgt gaacaaaggt ttgtaccatt 1700461 tcccttttct ttctgcggag gtagcgctcg attttttcgt cttctaaatc aagcagtttt 1700521 tcttcaaaat catcgaagaa aaattcgtca tgcgtggaaa ggcgctggat catttttgct 1700581 tcaaattcat cgattgacag caaaaagaaa agatcattaa gccgcttcgc ctgtttttga 1700641 tcgtaccgct cccactccca tgtatcgtat tggcggacga gctctgtgaa ttgatctaag 1700701 gcgtttgtcg gtttcatgaa gccattttca atgagatagc catataaaag cgatgtcgcg 1700761 gatgtgagcc ttccatcatc gtattccacc tggacaaatc cccattcatg ctcattcaaa 1700821 tgaagggctg ttttatgatg gtcaatgagc ttcactttgc cccctgcatg aacatactca 1700881 ttcaatctct cttcgttttc ttcattgacg gcgagatcgg tgatgaataa cgcgtcctgt 1700941 ctgttgctct ccttcgcttt ttctaaaaag tactgcacct gtgcgtttaa gccgttgaca 1701001 gagttatacc ggatctctac gtcttttccg aacgccaatt ttgctacgat tccgcatcct 1701061 actccgtcca agtcgttatg tgaatataaa tgatacataa tgtaggcccc tttttatgat 1701121 aaactgacaa ttgccgctag aggtgcggca gcctttattt actattctaa aaaaccaagc 1701181 gttttatgca atggtaatta gttgacataa tgttgttatt gtaaatatat aaaggagcgc 1701241 tttttttgcg ctcctaagtt cttgctttta caccggataa accggatgct ttcgattggt 1701301 aaatgtcatt tcctttgtca tgtatgcctt gagccgtttg gccagctcat cacgcagcga 1701361 attggctggg ataacagcat caatgatcat ttctgaagcc agacggtaga tattgatgtc 1701421 ctctttgtat tcctcccgtt tgctgctgat aaatgcggct ctctcttctt ctggcagctc 1701481 ggcgattttt ttagcgtaga cagcgtttac agcggcctca gggcccatga cggcgatttg 1701541 ggcggttggg agcgctagac agcaatccgg ttcaaatgcc ggccctgcca ttgcatacaa 1701601 ccccgccccg taagcttttc ggacaatgac agagagtttt ggaacagttg cctccgacat 1701661 cgcagaaatc attttcgctc cgtgtctgat aatcccagcc tgttctactt ttgtgccaat 1701721 cataaaaccg gggatatcgg ctaagaacag caatgggata tgaaaagcgt cacataaggt 1701781 aataaactta gccgctttgt ctgctgaatc gtggaataag acgcctcctt ttaccttcgg 1701841 ctggtttgca acaatgccga caggctgtcc gtggattcgt gcgaggcccg tcaataattc 1701901 cggtgcaaat aaggctttga tctcaaaaaa tgagtcttca tctatgaccc gctcaatgag 1701961 ctcatgcata tcaaaaggtg cgttttgatt ttgcggaatg acgtcggcaa gcggagtttc 1702021 gaagtgtttt ggcgggcgtt tctcatgaat gggcgctttt tcttgaaaat ttgccggaaa 1702081 gtaagacaaa taagcccgca ccagctgtat ggcttcttct tcagtttctg caagaatatc 1702141 tccgcagccg gagattgagc aatgcatacg ggcgccaccc atttcttcga gagacacttt 1702201 ttctccaata accatttccg ccatccttgg cgaacctaaa tacatggagg cgttaccgtc 1702261 taccataacg acgatatcac agaaggccgg aatataagcg cctcctgccg cagatggtcc 1702321 gaaaagcaga cagatttgcg gaatgcgtcc cgataatttg acttgattgt aaaaaattct 1702381 tcctgcaccg cgtctccctg gaaagacatt gatttggtcg gtaattcggg cgcctgccga 1702441 atcgactaaa taaatgagcg gacagtttaa tttttcggcg atttcttgaa ttctgatgat 1702501 tttttcaact gtttttgctc cccatgaccc cgctttcact gttgaatcat tcgccatgac 1702561 gcaaacggtt tggccgccga ttttgccgat agcggttaca actccgtcag cgggaagccc 1702621 gtctgacata cattccgcaa aaaaagcgtc ttctagctca atgtcatcgt caaagagaag 1702681 ggaaagccgc tctctgacaa agagcttgcc tttttcccga ttgctttgat gatacttttc 1702741 cgctccgcct tttcgaatcc gttcagcccg ttctgttcgt tccttttcat aatccatcag 1702801 cattgcctcc cttttatatt cccttgtata cggcccgtct tttttcttga aaggcctgaa 1702861 gcccttctct cctgtctttt gtcgggatgg tttgttcata cgctttttgt tcaatcgcaa 1702921 ggcctgtagc aagatctgtc tccaatcctt tattgattgc aaatttagcc tgacggacag 1702981 cgatcggtcc gttggcagaa atggctgcgg ccagttcctc tgcttttggc ataaggtcac 1703041 aaggagccgt gacatgctct acaaggccga tttcttttgc ttcgtgtgcg gtcacgcgtc 1703101 tgcctgtata aatgaattct tttgcttttc ctctgccaat cagccggggc agcctttggg 1703161 tccctccagc gcccgggata atagctaacc ctgtttccgg aagtcccagc acagctgctt 1703221 cagttgcgat tcgaaggtcg catgccaatg ccaattctag tccgccgcct aatgcgcttc 1703281 catttatcgc agctatgacc ggctgcggca aggcatcaag taaagccgcc gttctttgaa 1703341 tgagagatac actttccaga acctgatctt ctttcagttt tatccgttcc ttcaggtctg 1703401 cccctgcaca aaacgctttt tcaccggtgc ctgtgaggat gacgcaacgg atgtttgagt 1703461 taaattcaat ttcctggata atcatttgca ggtttctaag catttccgct gaaagagcat 1703521 ttgctgcctg aggcctgttt aaggtgatca acgccatatg ttcattttta acagtaaaaa 1703581 gaatagaatc tcccattgta tgcgtcctcc cttttatcaa gatgatttaa acacctgtaa 1703641 atttctgctc ggcagcggtt tgcccatttt ttcttcaatc catttggccg cagatagcag 1703701 tttttctagc tttacatttg ttttgatatc catctgttca agcatgtaca cgatatcctc 1703761 agttgcggcg tttcctgatg aacctggcgc atatgggcat cccccaagcc cgcctgccga 1703821 gccgtcgaac accgtgatgc ccatttggag tgctgtgacc atgttggcca gagcggttcc 1703881 tctcgtatca tgaaaatgca gggcaatttg attagccggg aatcgtgcca aaagagcttc 1703941 aagtacagtt tccacttggg cgggattagc tgctccaatc gtatctccaa gcgacagttc 1704001 agaaatccca aattcaaata gagcttctga aaggcgaatg acttgttcaa tggggacatc 1704061 tttttcgtac ggacagccga aaacagtcga gaggtaggct cttgttgtga ggtttgcttt 1704121 ttgtgcgtcg ttgtttactt gtttgagtat atggagggat tcagaagtgg atttattgat 1704181 gttttttctg ttgtgcgtct cgctggcgga cataaaaacg caagcctcgt taatgcctcc 1704241 ttcaagtgca ttctccagtc ctctttgatt cgggacaagt gccgcgtacg ttaccccttt 1704301 ttctcggtcg atgccttttg ctacatcgat agcatctcga agcgccggaa tccatttcgg 1704361 gtgaacgaag gatgtgattt caatatacga cagccctgtc cgggaaagct ggttgatcca 1704421 ggttatttta tcctctgttg cgatccaaac gggctcgttt tgtaagccat cacgcgggcc 1704481 gacttctttg attgtcactt ttttaggata tggcatggtc ttcctccaaa ttattgagtg 1704541 gaattgctca gttcgagcag tacgtctcct tcatttacaa agtcgccttc cttttttttg 1704601 acttctttta cgattccgct tctatctgca acgatcggga tttccatttt catcgattcc 1704661 aaaatggcta cctcctggcc cttttcgatt tggtcgccgg ctttgacgtg gactttccac 1704721 aggtttcctg ccatttgtat gctaaccgtc atgacaactg cctcctttat aggtgctgtt 1704781 tcaaaaagtc agtcgtgaca tccccttctt taaatgcctt tgttgccgca gcctgtatga 1704841 ggagcggaag gtttgttttg attccctcta cacgatagtc gcgaagcgct gtctctagtt 1704901 tttcaattgc ttctgttctg gtttggcctt tgacaatcat cttagcgatc atcgggtcat 1704961 aaaaaggggt aacggtgctg tcttttgcta ccgcacattc gtgtctgact cctttttggt 1705021 caggaagtga aaacgcagtg atcgtacctg gtgacgggaa gaaggtcttg ggatcttccg 1705081 cgtatattcg aacctctatc gcatgcccgt tccgttggat gtctttttgg gagaatgtga 1705141 gtgtatggcc cgcagcaatc cgcagctgct gctcaactaa gtccaggcct gttatttctt 1705201 cagtcacggg gtgttcaact tgcagtctcg tattcatttc gaggaaataa aaattttgtt 1705261 tctggtcaac tataaattcg atggtgcctg cgttcgtata gccgattgcc ttcgctgctt 1705321 ttaccgctgt ttgaccgatc ttcattctta gttcatcgtc tacaaatgga gacggtgctt 1705381 cttcaatgac tttttggtgg cgcctctgaa cagagcaatc acgttcaaac agatgtactg 1705441 tatggccgtg ttgatcggcc aaaagctgaa cctcgatgtg gcgcgcatgt tcaataactt 1705501 tttctatata catagacccg tcaccgaaaa aatctgctgc gcgctttttg tttccctcgt 1705561 acgctttttt taatgcttct tcattttcaa cacgctgcat tccgatgccg cctccgcccg 1705621 ctgaagcttt cagcatgaca ggatagccga tttgacttgc ggtgcggcag gctgcctcta 1705681 tatctccgag ggattcagaa acgcccggca ccacagggac acctgcagcc tccattgctt 1705741 ttcgcgcttc aattttgctg cccatctttg cgatgatatc aggggaaggt ccgataaaca 1705801 cgatgttttc ttgcttgcag cgttcagcga accggctgtt ttctgataac aatccatatc 1705861 ccgggtggat cgcgtcggct tttgcttttt tcgccgtctt tatgattctc tctatattta 1705921 aataactttc actgactctc gattccccga tcaaatatgc ctctgtagcg gcttttgtat 1705981 ggggcgcgtc cttgtctgct tctgaataaa cagcgaccgt tttaatgccg agacggctgc 1706041 atgttcggat aattctcatt gcaatttcac cgcggttggc gatcagtact tttgtaaaca 1706101 tgatttcacc tcattgactt gatgataagt tgaacatttc aatcgttttt tctcgcagtt 1706161 tatatttttg aattttgcct gaggccgtca tcggatagtc atccgtaaaa ataacataac 1706221 gcggaatttt gtggcgggcg attttccctt tgcaataggc tttaagctca tcaggtgaaa 1706281 cgcttttacc gtctttcagt ttaatccagg ctgcagcttc ctccccgaat ttggcgtcag 1706341 gcacaccaac cacctgtaca tctaaaacag cgggatgctg gtataaaaat tcttcaattt 1706401 cccgcggata aatgttctcg ccgcctctga tgagcatatc ttttaatctt ccggtgatgc 1706461 ggcagtaccc gtcttcatcc atgacagcaa gatctccggt aaacagccat ccgtcatgat 1706521 tgattgcttt tctggtcgca tctttgtctt tataatagcc tttcatgacg tgatagccac 1706581 gggtgcacag ttctccctgc atgcctcttt gaacttcttg acatgtcccg ggttctacaa 1706641 ttttcacctc agtatgtggc agggcacggc cggttgtttc gactcttctt atgaaggaat 1706701 catttgctct cgtttgtgta atgactggcg aggcttcggt ttgtccatag gcgatcgtaa 1706761 tgtctttcat gcccatcctt tcaatcacag ctttcatcac ttcacttgga cagggagagc 1706821 cggccatgat tcctgttcgg agcgtcgata gatcatatgc atcaaaatcc ggatgatgca 1706881 gctcggcgat aaacatggta ggcacaccat ggagcactgt gcatttctct ttttctaccg 1706941 ttttaaggac ggtaacggga tcaaattctt gcacgggtat catggctgcc ccgacggata 1707001 cacatgccaa aaccccaagg acgcatccaa agcagtgaaa aaacggaaca gggatgcaca 1707061 tgcggtcttg agaggttaaa gccatacatt cagcgatatt agcagcgtta ttgatgacat 1707121 tgaaatgggt cagcatcacg ccttttggaa accctgtcgt tcctgatgtg tattgcatat 1707181 taatcacatt gtctttatcc aggctgttca ttctctcttc aagctcagca tctgtcactg 1707241 ttttcgccaa tatctctgta tcgtcccaat gatacatgcc agacaatcgt ttattgccaa 1707301 tatagatcag cgtttttaaa aagggatagc gttcagattt cagttggccg ggctttgctt 1707361 cttgcagttc tggaattaaa ctgttcacga tgtctggata agaagtgccc ctgtatgaat 1707421 ccatgataat aagcgccgcg gcatccgatt gctttaacaa gtaatcaagc tcatgtgctt 1707481 gataattggt attgacggtc acgagcacgg ctccgatctt cgcagttgcg aactggacgg 1707541 caagccattc agagatatta gaagcccata tggcgacgtg gtctcctttt ccaatcccca 1707601 tccgcatgag acctttagcg gtttgacggc acagactgtc aaattgagcg tacgtatagc 1707661 ggatatttcg gtctggatac acaacagcat ctcgatcggg atacgcatca gctgtttgtt 1707721 ccagcagcct gccgattgtg gaatggatga gttcagccat tcattgttcc tcctttctta 1707781 atgataggaa agcgtttaca tttttatttt aaaagctgtc tggcgatcac gagacgctga 1707841 atttcagatg tgccttcacc gatttccatt aattttgcgt cccgcagcat ccgttccacc 1707901 ccatactctt tcatatagcc tgaacctcca tggatttgaa tggcttgatt gcaagctctt 1707961 gtcgccattt cagatgcgaa tagcttggcg tacgccgctt ctttggtgaa cgggcggtta 1708021 tgatctttca gccaggcggc ttttaacacc atttgccgtg ccagatcaat ttccatcgcc 1708081 atgtcagcaa gcttaaattg aatcgcttga aaggaagaaa tcggctgtcc aaactgcttt 1708141 cgctctttcg catatgccaa tgatgcgtca agggccgctt gggcaatgcc gactgcaaga 1708201 gcagcgatgg agattcgacc accatccagc gtatatagaa actgtttaaa cccttttgtt 1708261 ggatcgccaa gtaagttggc cgcaggcact cttacatctt caagcaagat ttccgctgta 1708321 ttcgaaccgc ggacgcccat tttatcgtac gggctcgtaa tcgtaagtcc tggtgtgtca 1708381 gttggcacga ttaatgcgga gatgatgttt tttccgtctt tgtttttgcc tgttacggcg 1708441 gttacaataa ctgtgcgtgc gtagcttgca ttagtgatcc agcacttttc gccgttgatt 1708501 acatactcgt caccatttga aatcgctttt gtttgagtgc ctcctgcatc tgagccggca 1708561 tttggctccg tcaggccgaa tgatccgagt gctgtgcctg aagccagcgg cgtcaaatgc 1708621 gtctgttttt gctcttctgt tccgaagtag taaagagggc ttgcgcctag cgagaccgct 1708681 gcagcatagc ttaatccagt actgccgcag gctttgccga cttcttcaac cgctaaggca 1708741 tatgaaatcg tatcaccgcc agatccgccg tattcttctg gaaatggaat acccatcaga 1708801 ccgagttcac ccattttttt aaatgtttgc atcgggaact cgcctgtttg atctacatgt 1708861 tcagcgtgag gagcaatttc ttttttcgca aaatctttta ccatttcacg caccatttgt 1708921 tgttcttttg tcagctcaaa attcacatcg tttcctcctt cacatctttg taacatccta 1708981 ttaggcgagt tctataatca ttccctgaca agaaaagtct gaaaattaaa actgaatcat 1709041 tttttatgtg ataatatcag cgggatgagc aaatacatgc agtaggcgca taccatccat 1709101 atcgtaaacg caataacttg gccctttgat aaagccggga agatgagggg aagattccaa 1709161 agggaaatcg tatccatcaa taaaccgacc gctgatcccc atatacctag cttgatcacc 1709221 gcgaactgtg attgatcgag tttttgatag agaaagaaca caaggcataa aacaagagca 1709281 gtgcccgctc ccaagagaag aaagttcggc aaaaaggctt cttcagccgg atcagtcaac 1709341 acagcatctc cgaacagcac aaaaaataat gtggcaccta accagactag aaatgaaaac 1709401 gtaaaacacg tcctgtacgt gtttctcttc gattttattt ttatttagta ctagtttctc 1709461 agattccaat aatggtaaat gtccaaacac cgcctccata ttcatgtgaa tctcaccttt 1709521 gttttttaaa aaattcagcg gtttaccatc gtttcctgtc ccaaaatcac tttttaaaaa 1709581 aagacgactt agaaagccgt ccttctcatt tcttattttg ttgttcgttt ggaagctttg 1709641 ctttcgttat gaagccggtc tgctgaagtg acataatacg tatatttctt gttgggatct 1709701 gccgtgttat ctaagaaggt ttgctgctca tgtgtttttc tttgcgttgc cagcaatgtt 1709761 ctctgctttt tcccttcggc tctgtatatc gcataatagg ctgtttcttt cgttttttga 1709821 tttgatgggt gatctttaat ctgcagaaga ttgccgtttt tgtcttcggt gactttcgta 1709881 agcttcggtt tttttggggc ggtattgtca agccaaggca tttgcggaac cagtgccggc 1709941 ttgctgtaaa gatcggtgct gagactgtct ttgatgccaa gcggattttt gttgaggtcc 1710001 ttgaggctga aatgcatgct tcctttcacc agttcaagct ggcggttcaa agtgatttgc 1710061 cgcacatatt cctcaggatc ggaccaaggc ggatcaaaat tgttattgat tttatatgct 1710121 gcctggccaa tatataagtg aacaggccta tttttgactt cattgctcca ccaatcagcc 1710181 agcacgtcgt aagccgctgc gttaaagccg atactccaat aaatttgcgg agcaatataa 1710241 tcgatgtcgc cttcttggat ccaatgcctt gtgtctgcat atagatcgtc ataatttctg 1710301 acgcctgctt ttgtattcga tccggtcggg tcatctgcgg cgtttctcca tactccaaag 1710361 ggactgatgc cgaatttgac atacggtttt gcagctttaa ttgtttggtt gatttgtttg 1710421 acaagctggt tcacattgtc ccgccgccag tcatcgatat tagaaaaagc gtcttttccg 1710481 tattgttcgt actgtgcttg atcaggaaat tcctgtcccg ctattttata agggtaaaaa 1710541 taatcatcca tatgaacagc atcgatatca taatgtttta cgacttcttc aatgcctttg 1710601 acgataaaat ctctcgcttc tggaatgcct ggatgataat acagctggtt tccataggcg 1710661 gcaacccaat ctggatgttt tcttgccggg tgatcctcag acaatttatt aagatctgta 1710721 tgattcattg taatacggta aggattaaac cacgcgtgaa attccaaatt tcgtttatgg 1710781 gtttcttcaa tcataaatgc aagaggatca tagccggggt ccttcccttg gacaccggtt 1710841 aagtattccg accaaggccc gtaagctgac ggataaaagg catcagccgt cggtttaatc 1710901 tgaacgataa cggcattcat tcccattttt tgcacatcgt ccagcagttt gatatactcc 1710961 tgtttttgct ctttcacaga taaccctttt ttggacggcc aatcaatatt taatacggaa 1711021 gcaatccata cggctctcag ctccctgtca gactgcgcat tggccataaa cggaacggaa 1711081 atgacaaacg ttccgatgat caagctgaca aggaaacgga caatcgactt ttggcaaacc 1711141 ttcattctgt ttcttctccc ccattacatc actttcacta ttcgctatta cggtattccc 1711201 gggctataaa agggtgatta acagaatgtc tatctcacta aataaacgaa aaaagtccta 1711261 aagcatgttg tgaaccgctt ttaggacttt ttatcattca tcatggtttg cagacttttt 1711321 aacacatcaa taagttttac gccgacaccg acagccgttt caaggatcgc ttgtgctccg 1711381 gcaatggcta aaataaagat cagcggtatt gcaatacgag gcaaaaaaag atagccaagt 1711441 ccgatcaaga tggcacacca aacaccggca caccagtagc aattgagcat gtatccaaag 1711501 ttagaagccg gcacgctttt ttcatctaca tgcccgtttt gatcaacaat ccttttcttt 1711561 ttcataaaag gttttcggat aaattctgtg attttgtcaa atacaatcaa atgtgtcagc 1711621 ctgtaactgg ctagaatcag catgataaaa gttagaaaag aaagacggtc cattgagaag 1711681 cctccaagaa aaaggatgat gttatcattc ccaagtgtcc cttatccatt cttgatacaa 1711741 aaagaaagac ggacagagaa tggcctctgt ccgctaatcc gagctcattc cctccagttc 1711801 tcataataag aggataagaa aatgtagaaa aaagcagaaa aatgacaata aaagaaatta 1711861 tatgactata taatccatat atgcactata ttaacggata ttttttaaag tacaataaaa 1711921 aacattaaat ttttataaca ttttttttga atatagtatt atttctttat ttttcgtttc 1711981 tttttttatc aaatttccgg atataaagtg ataaaagtat tgttttacat aaggtcttat 1712041 acactacttt ttaatcggac taattttctt ttgtgcatca ttcttctaat tgttggaagg 1712101 ttcgacaaag cgttattaca gacataaaaa aacctgtttt ctcttggaaa acaggtctcc 1712161 cgctattatt gatttgccaa aatgacagcg atttgatcct caatatcttt tccatcctct 1712221 tcatcaatca atccatttag aagaatagag aaaacaagtt tttttccgct ctttgtttct 1712281 gcgtaccccg atagagagct taccgtactg agcgatccgg tttttgctct tacttttcct 1712341 tgtgcaggag tgcctttcat gcggtttctc agcgttccgc ccaccattct gtcaggattc 1712401 cccgcaacag gtaaagaatt tagataagcc gagaaccaac tctgatcctg aatgtcatat 1712461 aacagctgtg aaagttgatc tgaggataca gcatcaatat gtgagattcc tgatccgtcc 1712521 cttaagacga gtgatttaga atcaacacca aattccggaa gcgtactgtt taacacttcg 1712581 agcccctttt cccagctccc ttctcctttt ttcactttcc ccatctcttt tacgagcact 1712641 tcggcatgtc cgttattact taatttcatg aacggcacaa aaagtttcga taaaggcatt 1712701 gagcgatgag agagcagcac atctgaagaa ctaggtgctt cacccgtctt gatgtcccct 1712761 ttcacagtaa taccttgttt ttttagtgac tgcttaaata aatctaaggc atatccggca 1712821 ggctcccaga cagaaatcca ttcctttgtc ttgtttgcgt caaccggtac gctcccttca 1712881 attgtaatcg tgtttgttcc atgctctctt tcgattgtga ggtctttctc tgaaccggca 1712941 gcagtcgttt tagcatcgtt ctttatcgtt atataatcgg ttttcggaga gacagacacg 1713001 gcaggctctt ccccttcttt ttgatttggg gtgacctcaa caatcacagt gcctgcatca 1713061 tagtcttcgt ttggagacgc tgttagagcg gagattggcg cgccataata tgtgtattca 1713121 tcgctccaag gcatatcagg tgataatcgc atgtcatcat gccacgtatc atcaccgatc 1713181 agattgcctt taattacttt tacgccggaa tgtttcaata tctcagccat tttgtcaaaa 1713241 tcagatggta aaagtgtcgg atcgcctttc cctttcaaat aaaggttacc attcagcttt 1713301 ttccctttca gtgttccatc cgtccggacc tcggttgtaa aagaatagtt ctcgccaagg 1713361 acagaaagtg ccgcggccgc tgtcaaaagc tttagagaag aggcaggcct cattcgggtg 1713421 tctcctgaat gttcatatag aacagcacct gtttccgcag agcgaacggt gatgccggcc 1713481 attgcgcctt cgagggcagg atgatcagct aaaatcttat cgatctgccc ggaaagtgca 1713541 tcttgttttt cagcggcaag cgcagcctga tgcatataag gcaccgaagc aacgacgaaa 1713601 agcagtaaaa cagcaacata aagctttatg ctttttttca ttaatttccc cgcctctctg 1713661 cgcttcatca ttggctattg atgattcagt tcaatggtga tactgctttt agctgtcgtt 1713721 tcttctcccg gctccagcac ttgtaaacca gtgagtgacg aaggtaaatc aagattcact 1713781 gcgtttgtca cccatgtgta aggctcaggg cataaatacc cttgttttcc gtccgcattg 1713841 tatacaaccc aatgtttaaa ctgttcatct gccttataaa taatgctgat atgtgcatgc 1713901 tgatgataaa tgactgcctg gttttctccg cccctcttct gataagaaga taaaaagaca 1713961 tcatccagct gcttgtggcg caaatccatt ccttcatgca aagcttcttt atacgggaca 1714021 tccatcagct tcccggtcgg cagcaggcgt tcatccaact cccattgctg atctgctgtc 1714081 agggagaata acgagctttc tgccggaaat ataaatgtag tatgataacc aattccccaa 1714141 ggaaacgctt cctttccttt gttcatgacc gtcgcatgtt taaatagggt attctccttg 1714201 atcgtgtatg tcatccgaac gacggcatga tgaggaaatt gcttctgcac atggggaagc 1714261 tcagaaagat caatttctgt ttcaacaatc actccttcat cagtttgctt cgtggtcacg 1714321 acattccact tttcatggta aagaaacccg tgaagatggt tgtgtttatc cttctcgttg 1714381 atatcaaaat gatacgttct gccccggaaa ctgaatgtac cgtcacttat gcggttaggc 1714441 gggaacagga ttggaatgcc atacaatgtt ggtgtgtcgt gaaaactttc tgctgtttcc 1714501 ggttcacgca aaagctggac atttgttgtt ttgtccacga gagaaatgac gttgctcccc 1714561 cactcaggga caacaatcat ttctagatgt tcgttgcccg ctttgatggc cggcgttccc 1714621 aaatacgtga ttttctcaat aaagtttgcc atgtttactc aacctctcct tgattcattg 1714681 ctagtataag aattcaatgt actgtaccat atttcctcca ttttatattt tcccctatca 1714741 aataaaaaaa caccgttcaa acttatgaac ggtgtgattc ggaggctatt ggatgagacg 1714801 tgtgatttgt ttctttttcc agacgaattg ataataccca taaatcaaca gcaagctgac 1714861 ggcaaacgca gctggataac caacccagac gccgagtatt tcaagctttg tatagtgaga 1714921 aaggacgaaa gcgacaggca cctctactcc ccagattgca aaaatactga tgacggtcgg 1714981 ccataaaact gttccgcttg cccgcatcgt tgcagaaata atttgggcat ttccaaacag 1715041 caaatagctc cacagtgtaa tcatcaaaag acggtgcgca atgtaaagcg tctcttgctc 1715101 ggttaaaaat aacgataaaa tctgatgtga aaaaacatag atcagaatga tcagtacgcc 1715161 gccaatgata taattcagcc aaatcccaac gcgaatgacc tgctttaagc ggtcaaactc 1715221 gtttgctccg atcgattgcg cagcgaaaat agaaaccgca ataccaaggc tgacggccgg 1715281 catctgtaca tagctggcca cctggttgac cactccgtat gcagctgttg cattagagcc 1715341 gtaatgattg acgaatgaaa taaccgctat ctctgataat gagacaagaa tcatattgat 1715401 gcttgctggg accccaagac gcagcaggag aaccagcagt tccttatcca ttttcaaata 1715461 acgacgcact gttttatcaa attgcagcgg gtgttttcgc tttcgtaaat acaccattaa 1715521 cacgagaaaa gtcgcaatcg tggaaatgac agttgcatat gccgagccgt atatgcccag 1715581 tttcggaaaa ccaaacatgc caaggattaa aacaggcaaa agcgcgatgt tgatgaccgt 1715641 gctcacaatc agcgtataaa acggtgtctt ggaatctcct gttccgcgca aaaaggtagt 1715701 atatgcaaaa tataaaaaca taaacggcat agcataaaat aaaatacgtg catagttagc 1715761 gctgacatga atgacatttt caggtgttcc cattaaacga aggatatcca gggtgaaaat 1715821 actgccgata acggctaaca caacgcctaa taaaaatgta aacgtgagtg tcgtcccgac 1715881 aacagccttt agccgttcct catttttcgc tccgtaagct tgtcctatca gaatcgaact 1715941 tcctgaaccg atcccaatcg taaatgagat taaaagaaaa aataacggga aaaaggatga 1716001 tacagctgcc actgcatcaa caccgagcca tctgcctaca gccatcatcc cgactagctg 1716061 gccgactgat tgcagcacat tgctcagcag aagcggcact aaaaagagtg acatcgaccg 1716121 ccaaactgat ggtttgcttt tcttttgagt tacaagaggt tcttgtgatg tttccatatt 1716181 aaaggactcc tttatttgaa atcgttttta aacatgccct cattttttga caaaaacagg 1716241 atatgtaaca tgttattatt catcactgca cttatgaaac ccttcccgat tcttctaatt 1716301 ttacacatct ttttagctta tgaagaataa actagcaagt aatggcgtat tttttgtgag 1716361 taaaagaata aaaaataatt tatgcaaaag tattgtaatc tatccgtaat tattgtaaca 1716421 tttgtaacat aagagaaaga gattttgaag gagagagcga taatgaaaaa atgtcttcta 1716481 tttctaacaa ccattgcact tattctgtca ttaagcacaa atgcatttgc gaaaaataca 1716541 tcaggcgatt tatcacaaaa acaagcatta cagttggcat tatccgctag agaacatttt 1716601 tggaacacca tgagcggcca caatccgaag gtgaaaaaag cagtttgccc atcaggcaca 1716661 ttcgagtatc aaaatcttca atatgtatac atgtgcagtg atctaggcac taaagcaaaa 1716721 gcggtgaatt atttaactcc tatttttaca aaaacagcaa tcgaaaaagg ctttaaagat 1716781 tatcatttca ctgtttcaaa aggaaaactt gctgttccaa tcggtgacgg agacaatctt 1716841 ttgaattgga aaaaatcaac tgctaaactg atctctaaaa aaggcagcac aatcacatac 1716901 gaatttactg tccctacatt agacggatcc ccttctgcaa aacggaaagt gacatttgtg 1716961 aaagaaaata aaaaatggaa agtcaatcaa tttgacgcag ttatataaga aaaacgcccg 1717021 gtataagcgg gcgtttttta tttggtttgc ataaagaaag acaacaggcg aaaagtgcct 1717081 gttgtctttt tgtgaatata acgctctagg agagattcga actcccgacc tgcagtttag 1717141 gaaactgctg cactatccgc tgtgctacta gagcttttgg tatttatata gtagctctga 1717201 tgatcaatat tttcaagcga tttgtattaa agccctccaa aaaccttata tgcggctctt 1717261 gtcgtatctt catcaatacc gatataccgc attgtaattg atggtgatga atgattcagt 1717321 attctctgca gctcggcgat gtctttcgtt cgctgataaa aatgatagcc aaacgttttc 1717381 cggagtgtat gcgtccctat ctcctcaagt ccgcacgctg cagcggcctc tcttaaaatt 1717441 ctgtaggcct gaatgcggga aatcggcttc ctggtccgca ctgatttaaa aagatattcg 1717501 ttttccttca tgtctttcgt atactcgtat atttcctgtt tcagcgattc taaaataaga 1717561 atctttcttt tctttttcgt tttgctttca gtcgcccata aatgatcttt attttgaacg 1717621 tccttcactt gcagcggcag aatatcagaa atacggagcg cgctgttgat gccgaaaata 1717681 aacagaaaat aatcccgctt gtttttgtta agcaaatact gtttgacttc ttggattttc 1717741 tctagactgc gaatcggctg tacaatatgc atcaaaaaac tccttaaaaa ccgttatgta 1717801 acattttgag gtctatgtta ctattatagc tgaaaaacgt tgaatgtcaa agtgcggcgg 1717861 cgtttatgta acataatata catagtgtta cataagcttt taaaaaagct tcttccaacc 1717921 ttcaccctat aaaataagct ttaaagcctc ttataaagct tttaacctct tggatactta 1717981 tccccctact aatcatcaaa aaacctctta aaatgaaatc tgacactccc aattttctgg 1718041 agcttccgca aaaatataca aaaaaagaca caatttcaaa ttgtgtccta atcctcatcc 1718101 tttacatcaa tatcttccgg gatcggttca tttaatattt cctgcacaag tgctttgtaa 1718161 ttctccagct gttcgagatg cgttttgaac tgttccttat aaatcaaaaa ttgctccccg 1718221 tcatgaacgg ctctgatttt cccttcgagc accaagcttt taatataatc ctctgaaaga 1718281 tttgtatatt ctgctgtttc ttcaatcgtt aaatacatat agcagtccct tcttaatccg 1718341 tatgctgatt ctaatatagc acatggctca tatcaatata atcaattctg cacagaaaaa 1718401 cggcattatg cactatataa tataccattt gtcacttgtg aaaacgctgt aattttttta 1718461 cgctaagatt gtaacaatac agcttcatat aggagggaga acatgaaaag aacgtggaac 1718521 gtctgtttaa cagctctgct tagtgttctg ttagtcgctg gaagtgtccc ttttcacgcg 1718581 gaagctaaaa aaccgcccaa aagctacgat gagtacaaac aagtagatgt tggaaaagac 1718641 ggcatggttg cgaccgcaca tcctcttgct tctgaaatcg gtgctgatgt gctgaaaaaa 1718701 ggaggaaatg ctattgacgc agcggttgcc attcaatttg cactcaatgt aacagagccg 1718761 atgatgtcag gtattggcgg cggcggtttt atgatggtgt atgacggaaa aacgaaggat 1718821 acaacgataa tcgacagccg tgagcgtgct ccagcaggcg caactcctga tatgtttctg 1718881 gacgaaaacg gcaaagcaat tcctttctct gaacgtgtaa caaaaggtac tgccgttggt 1718941 gttccaggca ctctgaaagg gctggaagaa gccttggata aatggggaac ccgttcgatg 1719001 aagcaattaa ttaccccttc tattaaactc gctgaaaaag gctttccgat tgattcggtg 1719061 ttggcagagg ccatttctga ttatcaggaa aagctttcac ggactgccgc aaaagatgta 1719121 tttttaccaa atggcgaacc gcttaaagaa ggagataccc ttattcaaaa ggatttggct 1719181 aaaacattta agcttattcg ctccaaaggc actgacgctt tttataaagg aaaattcgcc 1719241 aagacgcttt ctgacactgt ccaggatttc ggcggatcaa tgacagaaaa agatttagaa 1719301 aattacgaca ttacaattga tgaaccgatt tggggagatt atcaaggcta tcaaatcgct 1719361 actactcctc ctccaagctc cggcggtatt ttcttattgc aaatgctgaa aatccttgat 1719421 cattttaacc tttcacaata cgatgtccgc tcatgggaaa aatatcagct gcttgctgaa 1719481 acgatgcatt tgtcatatgc cgaccgtgcg tcttacgcag gtgatcccga atttgtaaat 1719541 gttcctctca aaggcctgct tcaccccgat tatattaaag aacgccagca attaatcaac 1719601 ctagatcaag tgaataaaaa accgaaagcc ggtgaccctt ggaaatacca agaaggatca 1719661 gcaaactata aacaagttga acagccgaaa gacaaagtag aaggccaaac aacccacttt 1719721 acagttgctg accgttgggg aaatgttgtt tcttatacaa caacaatcga acagctattc 1719781 ggaacgggta ttatggtccc tgattacggt gttattttaa acaatgaatt aacggatttt 1719841 gatgcgatac caggcggagc taacgaagta cagccaaaca aacggccttt aagcagcatg 1719901 accccgacga ttttatttaa ggatgacaag cctgtcctca cggttggatc tcctggcggg 1719961 gccacaatta tttcatccgt tttgcaaacc attctctacc acattgaata tggtatggaa 1720021 ttaaaagcag ctgttgaaga gccgagaatt tacacaaaca gcatgagctc ttaccgttac 1720081 gaagacggag ttcctaaaga tgtcctcagc aagctaaacg gcatgggcca caaattcggc 1720141 acaagtccgg tggatatcgg aaacgtgcaa agtatatcga tcgaccatga aaacggcacc 1720201 tttaaaggtg tagctgattc aagcagaaac ggcgcggcga tcggcattaa tttaaaacgt 1720261 aaataaataa aaaactgtac tcgcttcaaa tgagtacagt tttttcatgc agatctttaa 1720321 aataaaaact gacaaacgtc tttattctgc taatgcacgt ctatcttcat cttttcattt 1720381 cgtttatctc atcaagaaat gtctgaaacg cactcgtaat aaaaaagtct ttcctgtata 1720441 taaagacgat ctctaagtct tgatatgatg gtggcagctg atgaatccat acatttgtac 1720501 gatgctcgga gccgtcaaca gcggactttg ggagcagcgc cgtacccatc ccggcggaaa 1720561 caccttttat aatagcctcc aatgtgccaa actctatgat tttttgattg tgtatgcctg 1720621 cttcctctag taatcttttg accctgtcac gatgagaaca gccagcccca aaaaagagca 1720681 tcggctgctg aagcatgtct tctgccgtcc cttctcgtga tgaaatcaaa actaattcat 1720741 catgggagac atggagttgt ctaactgcag cgtgttcaac cggcccatat acaaaagcgc 1720801 catcaacttt atgatcaaga acctgttgaa tcaaatgatg cgtatcagct gtgttcactg 1720861 ataaatccac ttcaggaaaa cgcctgagga aggatgctgc atgctcaggc agatgcgtta 1720921 ccgccattgt ttccagtgat ccgatccgca aaggcccttt tggttgcctg ctcattcggg 1720981 tcgatttttc agcttggtct aacagcgata atacttgatc tgcatattgt aaaagatttt 1721041 ctcctgcagc agtcagcttc attccccgat tcgttcgatg aaaaagcctg atattcaaat 1721101 cttcctcaag gttatgcact ctggctgtca cattcgactg aacataattc agcatttggg 1721161 ctgctttcgt tatgcttcct tcgcgagcaa cagcctgaaa aatctttaaa tctccgcttt 1721221 ccacgcgctc tcacctgctt gctatgatga aaagtgatat tggctatcat atttgttcat 1721281 tttactcgaa gaaaaccgct atgtaaaata tgtaaagata tgaaaataca attaatgagg 1721341 aggcagacag catgaaagct gtaattcaca acggaaaagc cggtcttctg gggttatcag 1721401 ttcaggacgt tccatcaaca aagcctggat acggagaggt aaaggttaaa ttaaaatctg 1721461 caggcctgaa tcatcgtgac ttgtttctta tgaaaaacaa atctgaacaa gatcctcaca 1721521 tgatactggg ttctgacggc gcgggtatca tcgaagagat tggtgaaggc gtgaaaaatg 1721581 ttactgttca gacagaagta gtcattttcc cgacattgaa ctgggatttg acagaaaatg 1721641 ttccacctgt acctgagatt ctgggaggtc cttcggacgg aacacttgct gaatatgtga 1721701 tcattccttc acaaaatgca atcaaaaaac ctgcttattt atcttgggaa gaagcgggcg 1721761 ttttaccttt atccgcttta actgcatatc gggctctgtt tacaaagggg caattaaaaa 1721821 aaggcgagca tctattgata cccggcatcg gcagcggtgt agcaacctac gctttattta 1721881 tggctaaggc gattggggca acagtaagcg tgacctcccg cagtgaggag aaaagaaaaa 1721941 aggcgctgaa attaggtgct gattacgcat ttgacagcta cagcaattgg gatgagcagt 1722001 tgcagggaaa aaagatagat gttgttcttg acagcatagg acctgccctc ttttcggaat 1722061 acttccgcca tgtaaaacca aatggccgta ttgtcagctt tggggcaagc tcaggggata 1722121 atctcagttt tccggtgcgt tctttattct ttcctcaggt caatgttttg ggaacctcga 1722181 tgggaagcgg tgaggaattt caagctatgc tcgctttcat tgacaaacat aagctgcggc 1722241 ctgtaattga ccggatatat cctttagaaa aagcatgtga agcatataaa agaatgcagg 1722301 aaggcagaca gtttggaaac atcgggatcg taatggaata aaaaaagaaa ccggctggca 1722361 gccagaccgg tttctcttat atgataatcc cctttattta cggaagaact gaactcccca 1722421 tcaaatatcg atccacttca cgcgccactt cacggccttc attaatcgcc catacgatta 1722481 agctttgccc tcttcttgca tcccctgcgg cgaatacacc atcgatattt gtttgataat 1722541 ccccatatgc tgcactgatt ttgttattta ctgaattaac accgaactgt ttcaacagcg 1722601 gctgttctgt gccttcaaag ccgatagcga taaagacaag ctgagcaggc catacttttt 1722661 ccgttccagg cagctcgcgg aactcgtatt ttccatgctc atttttcact ttttccattt 1722721 ggatggtatg aagctctttc agctttccgt ttttatccgc gaccattttt gtcgtttgaa 1722781 tggagtattc tctcggatct cttccgaatt ttgcttctgc ttcctcgtat gcatattcaa 1722841 gcgtaaagac gtgtggctgt tcaggccaca tattgtcatt cgtgcgggct ggcggaagtt 1722901 tcgggtgttt gccgaattgg tgcacgcttt tggctttttg acgcagagcg gtagccacac 1722961 agtcagctcc tgtatctccg cctccgatta cgatgacatc tttccctttg gcatcaatga 1723021 attgcttgtc tttaaaatta gaatctaaat agctttttgt tgcaagtgtg aggtagtcca 1723081 ttgcgtaatg gactcctttt gagtcgcgtc cttcgattaa gaggtcccgc tgtttttgag 1723141 cgcctgtgca taagatcaca gcatcaaatt gctcctttag ctcatcagct gtaatgtcaa 1723201 caccgatttc tgtgttcgtg acaaaatcaa ttccctcttg cgtcagcaat ttaattcggc 1723261 gttctacaat gcccttctca agcttcatgt ttggaatgcc gtatgttaaa aggccgcccg 1723321 ctctgtctgc tcgttcaaaa acagtgacgg aatgtcccgc ttgattcagc tggtcagcac 1723381 tcgccagtcc ggctgggcct gacccgacga tggccacttt tttgcctgtt cgtttttttg 1723441 gaattctagg ttgaatccag ccgttctcaa atcctttatc gataatggtc cgctcgatgt 1723501 ttttaattga tacggccgga tctgaaatcg ctaaagtgca tgatccttca caaggagcgg 1723561 ggcatacccg ccctgtgaat tcaggaaagt tgtttgtttt caacagacgt tccaatgctt 1723621 ccttccatct gccccggtag acaagatcat tccattcagg aattaagttg taaatcggac 1723681 agccggatgt aaatccgtta atgtccgcac cgatctggca aaacggtgta ccgcaatcca 1723741 tacaccgcgc cccttgccgt ttcgatgctt cttctgaaaa aggagcagaa tattctttcc 1723801 aatcctttaa gcgagtgaga gggtcccgct ccgcaggttt ttctcgtttg atctccataa 1723861 atccagttgg tttccccatg ttcctctccc cttccttact gtactaccgc ttgtttttgt 1723921 cccgatgctg ctgtattctg ctttggcttc gtgttggcct caaaagcgaa catgatggct 1723981 tcttcatctg ataaacctgc agctttttgc tcttcgatgc ttgcgagcat ttgtttatag 1724041 tttttcggaa tgactttgac gaattttttc acactgtctt cccattgatc tagcagatct 1724101 tctgcttttt ggctgtttgt atacgcagta tgtctttcaa gcattgcttt gatttgctgg 1724161 atttctttct catcctctaa tgattcaaat aaaatcatct caaggttgca tttgcgttta 1724221 aacgctttga catcttcggt cagtacataa gcgattccgc cggacatacc tgccgcaaag 1724281 tttttgccta catcaccgag aacgacaacg ctgccgccag tcatgtattc acagccgtgg 1724341 tcgccgatgc cttctacaac tacgttcaca ccgctgtttc gaacggcaaa gcgttcacca 1724401 gcacgcccgt taatatatgc ttctccgctt gtcgcaccgt aaaaagccac gttgccgata 1724461 atgacattgt catccgaagc agagttgaat ccttctgatg acttgacgat gatttttccg 1724521 ccagaaagcc cttttccgac gtaatcattt gagtctccgt ccaaataaag cgtcatccct 1724581 ttaggaacga aagctccaaa gctttggccg gctgatccgg taaagtgcag cttgattgta 1724641 tcttcaggaa gaccttcttc tccgtaacgc tttgagattt cactgccggt tatcgttccg 1724701 gctacacgat ttgtattatt gatttcaatc gaaatatcag cttcttttcc agattcgatg 1724761 gcttcttgta cggccgggag aattgttgta atatcaagtg attgatcaat tttatgattt 1724821 tgcggcgatt ggaacgtccg caccccttca ggctgataaa gaagggtaga caaatcaagc 1724881 tggcttgctt tccagtgctc ctttgcccgt tcacttgcat gaagtacatc agtgcggccg 1724941 atcatttcat caaatgtctt gaagcctaac gcagccatgt actcacgaac ttcttcggca 1725001 atgaacagca tatagttcac aatatggtca ggatctccca tgaacttttt gcgaagctct 1725061 ggattttgtg tcgctacacc gacagggcat gtatccaaat ggcaggcacg catcatgaca 1725121 cagccgagta caactaacgg agccgttgcg aaaccaaatt cttcggcgcc gagcaaggca 1725181 gccatcacaa cgtcgcggcc cgtcatgagc tttccatctg tttctaatac aacacggtca 1725241 cgaagtccgt tcagcattag tgtttgatgt gcttctgcaa ggccaagctc ccacggaagc 1725301 cctgtatgtt taatactggt tttcggagaa gcgcctgtac ctccgtcata gccgctgatc 1725361 acaatgacat ctgcagtcgc tttggcaaca cctgcagcga ttgttcctac acctgctttt 1725421 gacaccagct ttacgctgat tcttgcgtca cggttggcat ttttcaaatc gtggatcagc 1725481 tgggctaaat cctcaatcga ataaatgtca tggtgtggcg gaggtgagat taatccgaca 1725541 cctggcgttg acccacggac atcggcaacc catggatata ccttgttgcc aggaagctgc 1725601 ccgccttcac ccggcttagc accttgagcc attttaatct gcagctcatc agcattgacg 1725661 aggtaatggc ttttgacacc aaaccgtccg gatgcaattt gtttgatcgc acttcttcta 1725721 tcatcgccgt tctcatctgg aacaaagcgt ttgggatctt ctccgccttc accgctgttg 1725781 ctttttcctc caagacggtt cattgcgatt gctaaagctt cgtgcgcttc cttactcaag 1725841 gacccgaatg acatcgcacc cgttttaaaa cgtttgacaa tcgattcagc ggattcaacc 1725901 tcctccaact tcaaaggctt gcggtttccg tcaaatgcga acaagttccg caaaaatccg 1725961 atgcgttctt catcagccgc ttttgtatac tgtttaaaca gattgtaatc atttctgcgg 1726021 cacgcccatt gcaaagtatg aatcgttttc ggattaaacg catgatgctc tccgccattt 1726081 ctccattgga agtcacttcc cggttcaagc gttttgctgt aatcatcctg atacgcttcc 1726141 cggtggcggc gctgtgcctc ttctgcaatt gtttgtaaat cgatgccgcc tagctgtgat 1726201 gcagtacctg agaaatagcg gtcgatcaca tcgcggctga ttcctaccgc ctcaaagatt 1726261 tgtgcgcctc tgtagctttg cacagttgaa attcccatct tggacatcac ttttacgacg 1726321 ccctcagtaa tgctttttcc atatttgcta accgcttctt catagctgat atccaaacgg 1726381 ccttcatcaa tttcctgctt gtaggtcgca taagcgagat aagggttaat cgcatctgcg 1726441 ccataaccga ttaacgctgc aaagtgatgc acttcacgtg cttctcccga ttccacaata 1726501 atgctgacct tcgtacgcag ccctttgcgg attaagtgct ggtgcagtgc gcttactgcc 1726561 agaagcggcg gaattggtgt cagtcgttcg ttcatctttt tgtctgataa aattaacaaa 1726621 cttacgcctt ggctgatggc tttctctgcc tgtgtgaaca tgtcctttaa accgcgttca 1726681 agatcctctg aaaacagcac atcaattttt tggcttttta aatcaggatg aacaatcgtt 1726741 ttcaatgcgt aaaactgttc attggataaa acaggtgtat acagtttaat ccggcgaaca 1726801 tttcgttcac ttggatgaag aagatcgcct tccgcaccga gccaagtcat cgttgaagtg 1726861 acaagctgct cacgaatcgc gtcgattggc gggttcgtta cttgtgcaaa cagctgttta 1726921 aagtagttaa acagcgattg cgctcggtca gaaagtacag caagcggagc gtcattcccc 1726981 attgaaccaa ggggatcttt gccttcttta ataacaggaa ttagatactt ttggatatcc 1727041 tcatatgtgt atccgaatgc cttctggcga gtaagaagat cactaaattg ttcttcttct 1727101 cttgactccg gatcaggatt tacttgtaca agctcttctt caagccattt ttggtacgga 1727161 tactcagttg caatttgtgt tttgacttcc tcatcggaga taatacggcc ttcttccagg 1727221 tcgattaaaa gcattttccc aggctcaagg cggtttttat ataaaacgtt ctcctgttca 1727281 acttcaataa cgcctacttc agatgagaaa ataatataat catcttttgt gacataataa 1727341 cgggccggac ggagaccgtt ccggtcaagg atcgccccga tttgtttacc gtcagtaaat 1727401 gaaatagctg tcggtccgtc ccaaggctcc atcagggagc tatggtactc gtagaacgcc 1727461 cttttttcct tggacatatg cgtattttcc gtccaaggct ctggaatgag catcattgcc 1727521 gtatgtgccg gtttgcgtcc agccatcaca aaaaactcaa atgcgttatc caaaatggaa 1727581 gagtcactgc catcagcatt gagaatcggc aaaatcttgt ttaagtcctc accgaagctt 1727641 tcagaaacaa attgctgctc acgtgctctc atccagttga tatttccgcg aagggtgtta 1727701 atttcaccgt tgtgaaccaa atagcggtta ggatgcgctc tttcccatgt agggaatgta 1727761 ttggtactga agcgtgaatg aacaagcgca aaagcagaaa cgaatgcttc gtcttgcaga 1727821 tcagaataaa atgcatcaac ctgttcaggt gttaaaaggc ctttgtaaac aatggtctgg 1727881 cttgaaagac tggcaaaata aaaatcaaga ccttccgtta ctccccaatt ttcagcctgt 1727941 ttacgaatga catacaattt tcgttcaaaa gataaattgt cctttagatc agaacttgcg 1728001 ccgataaata cctgacggac aaacggacag cttttttgcg ccactgttcc gatttttccg 1728061 acatttacag gtacagttct ccatccaaga acgacttggc cttcttgttc aattagtgca 1728121 ttgatttgct tttcaatttt ttttctttca tcttccttct gtgagaaaaa gaccattcct 1728181 accccgtaac gttctttttc tggcagattg atgtttttgc actcttttct aaagaaagca 1728241 tcagggattt gaaccagtaa gccggctccg tctcctgtat ccggatcact gccttgccct 1728301 cctctatggt ctagctggca aagcatctta agtccttgtt tgacaatgtc gtgagtctgc 1728361 ttgcccttta agtgtgcata taggccgatt ccgcatgcat catgttcaaa ttcaggacgg 1728421 tagagacctt gagcttttgg catttgattg tacgtcataa ttcctctccc ccgatcaatt 1728481 tccgataata ccggtcataa aatctaacaa ctctataatc attgtaggtt ttcaaaacga 1728541 tataaacaat atataattta gatcaaaaga atctcaaaat gagatagatg gatgtgagac 1728601 aaacatggag ctgcgccaac tgcgttattt tatggaggtg gctgaaagag aacacgtttc 1728661 agaagccgct gatcatttgc atgtggccca atcagcaatc agcagacaaa ttgccaatct 1728721 tgaagaagaa ttaaatgtga ccttatttga gcgtgaaggg agaaatatca aactcacgcc 1728781 aatcggaaaa gaatttttaa ttcatgtgaa aacggcgatg aaagccattg attatgcgaa 1728841 agagcaaatt gatgagtatc ttgacccgca tcgcggaacg gtaaagatcg gctttcctac 1728901 aagcctcgcc agccagcttt tgccgactgt catttcagcg tttaaagaag aatatccgca 1728961 cgtcgaattt ttgctgcgcc aaggctccta taagtttctg attgaagctg tcagaaaccg 1729021 cgatattgat ctggccttat tagggccggt gccgacgaat ttctctgaca taacgggaaa 1729081 aatattattt actgaaaaaa tttacgcgct tgttccatta aatcatccgc ttgctaaaca 1729141 aaaaacggtt catttaatcg atttgcgcaa cgaccaattt gtattgttcc cggaaggatt 1729201 tgtacttaga gagatggcaa tcgatacttg caaacaagca ggctttgctc ctctcgtttc 1729261 cacggagggt gaggatttgg atgcgatcaa agggttagtg tccgcaggaa tgggcgttac 1729321 ccttctgcct gaaagtactt ttgctgaaac aacacctcgt tttactgtga aaattccaat 1729381 tgagttccct caagtaaaac ggactgtcgg aatcattaaa ccgaaaaata gagagcttgc 1729441 gccttccgcg aatgattttt atgagtttgt cattcaattt ttctctaagc tggagcagta 1729501 tcaataaaaa aaatgaaccc gagcttctat atagaagctt cgggtttttt tctgcaaatt 1729561 aatttacagg taaagaaaaa tccacatggc aaacaaatgc ttcttgatca attagagctc 1729621 tatttgtcag ttcctttttc ttttccggtt cttgaagctg tacagaagag taattgacga 1729681 ttccaaggcc gatttccgtc ccttttgaat ccatcagccg aacaactgaa ccgcttttga 1729741 atttcccttt aatcttctgt acaccgtcta ggtataaact cgattgtccg tttgttattt 1729801 ttcgtgaaca atcatctgat aaaatcattt caccttccgg accggaatta aaagcgatcc 1729861 attgctcctt ttgattcaac ggaagcgttc cttctgcttc aaaataggtg ccttccgcct 1729921 gttcatgaac ggcgtggtat aaaatatcgc cagcatctgc ctgacctagg aaacctttaa 1729981 tgccagacgc cattacgatt ttaaacgcat caagcttaga gcgcatgccg ccggtgccaa 1730041 cgatgcttcc agtgtcacct gcgcatgctt cgatgtcagg tgttatttca ctcacccgct 1730101 gtatcttttt cgcttctgga tttgtgcgcg gattgccgtc atataatccg tctatatctg 1730161 ataaaatcac aagcatatct gcatcaatca atcctgcgac ttttgctgcg agcgtatcat 1730221 tgtcgccaaa cttgagccga ttgacggtaa ctgtgtcatt ttcgtttatg atcgggatga 1730281 tgccgcgctc gagcagtaca ttcattgtat tcctgacatt gttgtatcga tattcatcag 1730341 aaaaatcgct tctcgtaatt aaaatttggg atgcgacata gccgtgtgcc aaaaacagct 1730401 ttgaataagc ctccattagc aatccctggc cgattgaagc tgatgcttgt ttttctggaa 1730461 gcttctcggg cctttggata aatccgagct tccgatatcc cgccgccact gcgcctgagg 1730521 aaaccaaaat cacttcataa ccggcgtctt tgagtttgac gacctggtcg accaacgctt 1730581 ctaattttcg aatgctgatt tctccatgaa ggcttgttaa tgaactgctt ccaatcttca 1730641 caacgactct tttcatgctt gtatcaggcg tcactttatc actcctgata gcggcgctgc 1730701 agttttttcg atatcttcgc tgatttcctt tgaacgctta gccgcatgct ttattgcttg 1730761 agaaatcgct tctccgccgc cgctcttttt caaggcttgc agccccgctg ctgtcgttcc 1730821 gttcggtgac gtgatattat ctcttaagat ctcaggatgt tctcctgttt ccatgagcat 1730881 ttttgcggca cctaaaagtg tctgtgcgcc gatgcttcga gataactgtt tatcgaggcc 1730941 cgcttcctcg cctgtctttt caatgaattc cattaaataa taaaaatacg cgggtccgct 1731001 gcctgcaatt ccggtgaata tatccatttg attttcttgg attgtataga cttcgcccat 1731061 gcatccgagc aatgcttcgg ccagcttctt caggtcttcc gacacatatt tgccaagggc 1731121 aatagctgtt gcagaagcgc caatcatact ggaagtgttg ggcatcactc tgacaaccgg 1731181 ctgttcatta agcaatgatt gttcaataaa agaggtagtt atgccggcaa ggaccgacaa 1731241 tattaattga tggggttgaa tacgtgattt tagtgatgac agagcgtttt cggcgtcttt 1731301 tggcttcatt gccaaaatga gcacatccat gtcttcaata catagttggt tcggcaaggc 1731361 gcctttaatg ccatattgaa gttcaagttc agttaatcgc tctgtattgc tgcggtttgt 1731421 aacgcagatg ttttgtttcg ggattttgtt ggctcgaacg atacctgata tcattccttc 1731481 cgccatagat cctgctccta taaaggctac tttcttttga tcaaagatcg gtaacatctc 1731541 ctttgttcgc ttttttgttc gcattttcac acgtttaaaa tgttaccacg tgaggaaatg 1731601 atgtcaagtt tgaaggccat tattgatttg tattgtttct tttcgacaaa tatgtataat 1731661 gaaaagcaga aaacacccgg ttcacactgc tgcgccgggt gtttgtttct attaaaaatt 1731721 atctgagaga gctttttcaa tcagtttttt acagcgatcc agctctacct tcagctgttt 1731781 tttatatagc ttggcagctt cgtaatcttt aaattgatag aggacgactt cctggagctt 1731841 agccccttct ttttttactt taatttgttt tagtatcccg tcatcaagaa gctcatgcaa 1731901 agaccggtat acttctgtat gatttggttt aaaaccaatc tctttaaatt cagaccgaag 1731961 tacttcaagc agctttaacc catagagtct ctcttgctct gtcatcgtta tcatataaag 1732021 cttcaaaaat gcgcgctgtt tcactaaaaa gcctgttgaa ctcctttttt cttctttcat 1732081 catatgcact ccttcttctg tcactgacaa cactatgtac taaatattca attttctttt 1732141 attgttttcc ttctttatat taaagactga tagtccagtt atttcatgtt tactgattat 1732201 aggtgtagcg gaaaaaataa atttcgactg aacatttggt acatagtttt cttagttcta 1732261 ttatagcctg catttactgc tatcttcaat ttaaacgatt gccagggttt acatatctca 1732321 ttttaccggt acggatttca ttcaaataaa aaaacctgtc gaaagacagg ttttcatttt 1732381 taaggatttg ttgaccataa tcccgctgtt ttgatgaaaa tacgaggatc taatttcagt 1732441 tgtgccacca tgtactcagc aagatcctca ggctgcataa ctttttcagg attaccgtct 1732501 gttaagttca attcgataga catatcacta gcgacagtgc tcggcgttaa cgcgctgact 1732561 ctgatattat gttttctcac ttcttgcata agagactctg ttaacccgag aacggcaaat 1732621 ttagaagcgc tgtaagcact tgttacagca gctcctcttt ggcccgctgt agatgaaata 1732681 ttaatgatgt ctccggcttt gcgttcgatc atttccggaa gcaccgcgcg agtgacatgg 1732741 tacacaccca ttaggttgac ttgaataata ttttcccact catcagctga cagatctaag 1732801 aaaccgccaa atttgctgat gccggcatta ttaatgagga tatcgatatc accgagctgt 1732861 tccttcactt gagctacagc ttggttaacc tgatcggcat cttttacatc tgcagcagca 1732921 aatgcagctt ttacaccaag cgctttgact tcttcagcca ctttttctac attagcggaa 1732981 gtccggccaa ttaacccgat attcacgcct tctttggcaa gcgccagagc agtagcgcgg 1733041 ccaattcctc tgcctccgcc tgtgattagt gcagttttat gttgtaaact ttgcaattga 1733101 agcacccttt ctttgtttac atatgtacga tatcacatta taagtacaat acatccaata 1733161 cgcaaatcaa acgaactgtg taaatatcat ttcttctgat taaaaaaacg gatacagggt 1733221 aatgacataa gaaaaggagt gaacatatga ttatagttta tatcagtctt gcagtattag 1733281 cagtttctat tatcttctta ggagttaccg tgatccaaaa caagaaaaaa atagaccccg 1733341 cactaaagga gctttcctct gttacgcagg ctatgcaaaa acaaatcgaa ggattaaaaa 1733401 cagaaacaga gctgctgacg caaaaacaaa agaagattca gcaggatgtc caaataaaaa 1733461 aatacacgct tcagcagacc gcagctgaag tgaaagaagt tccccaagca gtcaaagagg 1733521 tgtggcaggc aggacatttt aatagcagat aaggatgaat gagatcccgt tgttacgatc 1733581 agaatggaca aatgggatct catttttcga ggaggcttac acatgattat aaaccgcagc 1733641 tgcttaaaag agttcgcaga aaaagtacat tttcttccct cttcacttac aaagtccgat 1733701 ttacttactg atccatttcg tctccatcaa gaaaacgaac ttggcatcta ctattcacct 1733761 cataatgaat ttatcaatcg ggatgcctcg cttgtgattg ccgggatcac gcctggtttt 1733821 tcccagatga agacagcgta cgaaacagcc gccgaaagcc tgctgcaagg cgggactctt 1733881 gagcaaatgg cagtagacac aaaaatagca gcgggtttct ccggatcgat gagacataac 1733941 cttattacca tgctggattt atgcgggctg ccgcaagctt ttggcattca aagcgccgca 1734001 aagctttttg gagaattacg gcatatgctc catacaactt ccgttattaa atatcctgtc 1734061 tttatccagc aaaaaaacta taccggatac aaaccggcta tcactcattc tcctatccta 1734121 agcacttatg cttttgggca cttccctgca gagcttaacc atgtgacggg accagctctt 1734181 ctcattccgt taggaaaagc ggccgaaaca gtgtgtgaaa cattgatcag acagcacagc 1734241 ctccagaatt tgatttgcct taacggcttt ccccatccat caggcgcgaa cggccatcgt 1734301 ttgaaacaat tcagcaaaaa caaagagcaa ctagaaagac aaattcgttc ctttgctgca 1734361 ttggttgatt tcgctataga aaagaggaaa taaaagggat atgataaaca aaaacacaaa 1734421 cgtggggagt ggttgaatgt ttcctatatt agaaacggat cggcttatac ttaggcaaat 1734481 cacagatcag gatgcggaag ccatttttgc ttgtttctca aacgatgagg tgacacgcta 1734541 ttatgggctt gaaaacatgg aatctataga acaggccatt tcaatgattc aaacgtttgc 1734601 tgccctctat caagaaaaac gcggtatacg gtggggaatt gaaagacggg acactaaaga 1734661 actgatcgga acaattggct ttcacgctct ggcccaaaag cataggcgcg cggaaatcgg 1734721 ttatgaaatc atcccggagc attggcgaaa cggatttgca tcagaagtca tttcaaaggt 1734781 cgtatcttac ggattttctg cccttggact gtcgcgtatt ggcgcagttg tatttaccga 1734841 taatgaagca tcaaatcgtc tgcttctaaa aatggggttt caaaaagaag gcgttttaag 1734901 acagtacatg tatcaaaatg ggactccata tgatacaaat gtgtactcta ttgtgaaacc 1734961 aagagaatga cggtattctc ttggtctgtg ccacatccct tttcctttaa aaagataaaa 1735021 agcgcccctc aaacagggcg ctttctaatt aagatgcata ttgaggagat gtttcctcct 1735081 taactgcttt ttcctcaggt atatgaatac attttgtcaa gaccgcactt gcaaggtaaa 1735141 gggccgcaaa gatccagacg acaccttgcg cgccgacgag accgatgaac agccaagcga 1735201 gtgcagggcc gacaaacgct gataaacctg cagctaaatt caatacagac atggctgccc 1735261 ctttatcttt tcctgccacc gtcggcacaa ttgcaccaat cggcacatag cctgccagca 1735321 aaccgcccca aataaagccg atcacgctga caaccgctaa acttccgccg gagaaaacag 1735381 gtgcgtagta taataagacg gtgaaaatgc cgcagccgac tccgccgaac caaataacag 1735441 tatttttcca gccgaattta tcgccgacaa taccgaagat aaggttaaac acaatgttcc 1735501 ccaggaaaat cgttccccaa atttgcagcc acacattggt tgaaattcca tgctgggcca 1735561 tgtgcatcgg caaaaagact ggaaaaccat atgtaccaat gctgttgatg attctgatga 1735621 ttccgcctgt aagcacgcgc ggatttgtaa atagaatcgt aacccctttt aaaagctcct 1735681 cggctgtttc tgatcttttt cttttcttct tttcaaaacg gtctttattg ataaacaatg 1735741 caaagaatgc accgagacat acccagaaaa tagagctcca aagcgtattc aaataaccga 1735801 acgctttgat cgcgtagctt gagtaccaag cgccgaacac aaacatgccg aggcaatatg 1735861 caatccaaaa ccagccgaca gcagtgctca gtttgctttg cggtgttctg taaatgaccc 1735921 atgtcaagaa agaataagca aaaagcgggt aacctaaccc ttttacgaag taagtcacat 1735981 acatcactgg caggttcagc tgttcaaatc caaatacgat aaaagcagct gtaccgatca 1736041 cataaaacaa cagccccata aacatcgttc gttttgcgcc aaatgcttcg agacatacac 1736101 ccgaaaacca ggaagctatg gcaagcgcaa ttccgtatat actaaaaatg gaagcggact 1736161 gctgaacggt gagcccgttt tcgatcaaaa aaggactgag ccagccttgt tcaaggccat 1736221 ctcccatcat aaacaaaaca acccctaaaa atccccaggc aagccgcttc ggtattccta 1736281 ttttatccaa catatctgtc tcctccttag atgctattat tcattaccgt attaccttat 1736341 taaagttgaa aattaaatga ttcctcaaaa cagcagaaat tccgtcttaa attaatactt 1736401 tgctttctga tcctgaaaaa aagcgctgtg tttgcttcca ttcctcatat aaagccaatt 1736461 ctatctgaca gtccttcggt tcgatcaccc ggacatttgc tgacatctcc tccgttaatt 1736521 gaaaggtttc attgcaaatg actgcagcac cgacgacaga tgcctgatga tatccctctt 1736581 ggacatagac ctttttttga agaagatccg cgatatattg agtgagcgct ttgctttgga 1736641 atccccctcc gcacacccaa acataatcac gttcaaacgg agtaacctct gttaaaatgt 1736701 caaagttcca tttgattgaa aatgcgatct cttctagcgc tgcacgtaca aaatgtgccc 1736761 tctttaaatg tgctgacagc ggggcatcaa aaagaaaacc gcctctcgtt aacgcattct 1736821 tttcagccga taaataagag ccgagagccg ctacacatgc atggtcttct tttgcaagtg 1736881 cagaaatctc ctcctccatt acttcgtacg tttcattcgg ataaaaaatc tgttttaatt 1736941 tttgataatt caagccggta attcccggat tcgtttccac aagccaatgc ccttgatccg 1737001 tatgacagtt caaccaggct ttatgttttg tgtcgccatg atcctcagta attttggtta 1737061 ttggcgttgt tgtccctgat acaatgacaa tgtcctcaag tccagctccg gtgcttttga 1737121 cagccagctg tgtatccccg ccccctgcta taaccttagc atttattgaa aggcctaatt 1737181 cggatgcata ttcatttgct atcgttccaa ttgctgttcc cgctcttaca agaggcggaa 1737241 ggatagatgg agaaaagccg aaaatgtcgc acatctcttc tgaccaagtg ttttgcttca 1737301 catcaaatag cagggtttct gttgcctgtg atggttcata tgttaatatt ccgctcagtt 1737361 ggtacgtcac ccaatcactg atgcttgtaa agcttgcagt cttttcccat aaagagggct 1737421 ggcgctgttt taatccataa agcttgagcg cagaaaaaag tgcagttggc aggcggcctg 1737481 tgctgctgta tatctcttcc caatcgggaa tgcccgcctc ccactctcgg ccgcgattat 1737541 cgatgttcgg cagcccgaga aaaggattgc cgttttgatc aatcaaaaca atcccctgtc 1737601 tttggctcgt cgatgtcaaa ccaatgatgt caatatcaca cgaacgggat agcgcacgtt 1737661 ttgccaaatt catcacctgc ttccacagca cctgaggaga aaaataacgg ctgtccgggt 1737721 aaagcgtctc tgtggaatac tcgatgtcct cccgttcaac tgttagaaca ctgccagtta 1737781 cactcacgac cgctaccctc gcattgcctg tgccaatatc aaaaacgaga tagccttttt 1737841 gttttttcat tctgttagcc tcctttctta tccccctgtt ttcagtgcgt ccttgttata 1737901 cattgtctga atattaagag ttttttcacc cttccacttt ttgagggctt tattcagtat 1737961 cgtcacgtga tgatcctcca cttcaaatgt tgctccagcg agatgcggtg ttgccagaac 1738021 attaggcaat gaaatcaatt cataatctga ttcctctgga ggttcatgat aaaaaacgtc 1738081 tagtatcgca ccgctgattt tatgttcttt taatacaaat aaaagatctt cacggtttac 1738141 aacaactgct cttgaagtat taacgaaaat cgcactctct ttcatcagat caaaatattg 1738201 ccgatctatc agtccgagtg tttcctcagt gcgaggcaga tggacagaaa cgatatcgct 1738261 gtctgaaaac accgttttaa gagatgcttt ttcatacaac ggatgatcgt cttgaatgta 1738321 tggatcgtaa tattttatct tacagtcaaa cgcagtcagc agttttgcaa tcctttgccc 1738381 gactgcgccg aacccaatca tgccaaccgt ttttcctgtt agctcatttc ctttaaattt 1738441 gacataagcc tgcaggtaat cactgtccca ctctccatcc ttcagccact gattcgaggc 1738501 gctggtatgg cgcagaaagg aaatcacatt tccaataaac atttcggcaa cggcttgtgc 1738561 attccgccct ggtgtataaa aaacaggtat gccccttttt gaggcagctg ccacatccac 1738621 atttgagggc attcccctgc aaacaccgac aaatgaaagt tcgggaacag aagcaaatac 1738681 gctgtctgtt acctgatcaa gttcagtaat caagcctgtc gcatttgttg cttttagcag 1738741 ctgaatgagt tcatcctccc gatatgccct accttgttcc ttccaagatt gataagcaac 1738801 tgagccaaac aagttttcaa gctcttttcg tccttcttcg ttgtacggtg ctgtaaccaa 1738861 aaccgtcatg ctgcaaaaca tccttttcat cgtatttttc ataaaaaaaa tctctttccg 1738921 aagatggaaa gagattcata tataggcgcg ctctgttaca ggcagacgcc ggtataaacc 1738981 ttgctttcct atctttcaag ctagcgcttg ctggaattgg cacaataatg ttgccgaggt 1739041 ttcatagggc cagtccctcc acctctctgg atagaaaata ttgagtatgt aattttcaga 1739101 atgaagaata cgtttatcat aaagaagact cagattgatg tcaatctctt tttttcagaa 1739161 ttgacgttat catcggaaat gttataattc ttacaaaata tctaactaga gagaggaact 1739221 gggccatgag atcttttgcc acacaacaaa acggcatttt caaatccgtt tgctcgctgg 1739281 actgcccgga tcagtgcgga ttgttaatac ataaaaaaga cgggaaaatc gtaaaagtgc 1739341 aaggagaccc tgatcatcct gtcacagctg gaaacatatg caacaaagtc cggaatatga 1739401 cggagcgcat ctatgatgaa aagcggctga ctacaccgct caaacgaaca ggtgcgaaag 1739461 gccaagcgat atttgaaccg atttcctgga aagaggcaat cgatacgatc acctcccgct 1739521 ggaaacagct gattgatgaa gagggagctg aaagcatact tccttacagc ttttacggaa 1739581 atatggggaa attgacagct gaaggaatgg accgccgctt tttttaccgc atggggtcaa 1739641 gccagcttga acggacgatt tgcagcaaag cgggatctga aggctataaa tatacaatgg 1739701 gcataagcgc gggaatcgat cctgaggaaa ccgttcatac aaaactattt attttttggg 1739761 gaatcaacgc ggtcagcaca aatatgcacc aaattacgat cgcccaaaaa gcgcgaaaaa 1739821 aaggtgccaa aattgtcgtg atcgatgtgc ataaaaatca aacaggacgt cttgcagatt 1739881 ggtttatccc aataaaaccg ggaaccgaca gtgcacttgc tcttggcatc atgcacattt 1739941 tatttaaaga aaaccttcat gatgaagcat ttctgtccga gtacacggtt ggctatgaag 1740001 agctccgtga acacgtgaaa caatatgatc ctgaaaaggt atcgacgatc accggtgtca 1740061 gtaccgaaga tatttaccga ctggcaaaaa tgtacgggga aacctcccct tcttttatca 1740121 gaatcggaaa cggaccccag catcacgata acggggggat gattgtaagg acgattgcct 1740181 gtcttccggc gatcaccggc caatggctgc acacaggggg cggcgcaatt aagcataaca 1740241 gcggaatttt agaatataac acaaatgcct tgcagcggcc cgacttattg aaagggcgca 1740301 ccccgaggtc gtttaatatg aatcagcttg gcagggtgct tttggaaaca gacccgccga 1740361 ttcgctctct atttatttac ggaacgaacc ctgccgtcgt cgcgcccgaa gcaaacaaag 1740421 tcagacaggg cttgctgcgg gaagacttgt ttactgtggt tcatgatttg tttttaacgg 1740481 aaacggctgc atatgcggac attgtactgc ctgcaacatc cgcttttgaa aatactgatt 1740541 tttacacctc ctactggcac cattacattc agcttcagca gccggtgatt gagagatatg 1740601 gggaaagcaa gtctaacact gaggttttcc gattactggc tgaagccatg ggattcacag 1740661 accaggagct taaagattca gatgaagtat taatccgcca ggcgcttgac catccagata 1740721 atccgcattt ggcagagatt gattacgatt cacttactaa gcattcattt atgaaagcga 1740781 aacgtgaaaa gccgctgttt ccgggcgaac ttccaacgcc aagcggaaaa atagaattat 1740841 attcagaaaa aatgaaacaa gacggcttcc ctgctttacc gacatataca cctcttgtaa 1740901 ccgataatga acatccgttt atgtatgttc cggggccaaa ccataatttc ttaaactcaa 1740961 cattttccaa taatgaaaaa cacatcaagc ttgaaaagac gccaaagctc tttatcaaca 1741021 caaaagatgc tgaaaaacac ggaatcgttg atggggcacc tgtacgaatt tggaacagcc 1741081 ggggagaatg cgagctgacc gctgcagttg gagaacaagt gctgccaggt gtcgttgtca 1741141 gccaaggatt atgggcggat gaacaaggaa aaaaacagct tgtaaacgcg ctaaccccag 1741201 atcgcttgtc cgatatgggc ggcggcgcca cctttttttc aggccgtgta cagattgaaa 1741261 aggtttgaaa aataatgaaa cccggagtat gccaagcccg tataacataa catcgacata 1741321 atggaggcat acacatggac gtttttttag gaattggtat tgctttggct ggatatttta 1741381 tcggtgaagg cttaaagcag aggaaccaaa ccaaaggtaa tgaacaaaat gatatcttcc 1741441 taataaaaga acgggatatt tacttttaca ttggactttt tttaggaata acaacgactg 1741501 aagcaaaaca gttagctgga gacatggcag acctgcctta catcgaaata aacggaaaaa 1741561 aatatgtcca gaaacatatg ttaaaagatt ggacattcac attagttgaa aaacatcagg 1741621 gtgaataaaa caaatctgag gagagcgaga ttcattgtca cgctctcctc tgtttagctg 1741681 tatggatcct gccaccaaaa ctttgtgcta taagcgctga taaaacgata aaccaccatc 1741741 tatgttcttt cctcaaacaa ctcaagatgc ccgttccaca acaatagttt ttatattcct 1741801 ttgatgacgt gatgttcttg atgaacgtat gtatcgtaaa acacttagaa aacctattcg 1741861 gtttgaatgt gtgctctcat tatgccccca tactgcgcct ttatccgcgg aggatttttt 1741921 taaaaaaata tgaaacctaa agcttttaga tcctgaattt ttattgaacc tccatatttc 1741981 tccgattggt aaaaattagc ctatacaccg gaagctgtac gtttataaag gatcagagaa 1742041 tcccataacc agtaaatcac tgcagccgca atacttaaca tataataaaa gtacgattgc 1742101 aatgtccatg ctattgacgc aggttcattg ataacaaaaa acaggaaagc tgcgataaaa 1742161 gcaaccacac tgtaaatcaa taggtacatg acattgaaag ttctcgcttt tttctgcaac 1742221 ttcatttgga gcggaacagc aaaaaggcca tacaccacaa aaccgtataa taaagcaatt 1742281 gctgccgtaa acaatgcaat tatcatatcg ccatacataa cgaaagaata aaaccctaat 1742341 aacaaaccaa atgtaaggct ggatagccct aatgtcatta aataatatga tgcgattttt 1742401 ttcatttttt cacccccctt gtttgattta ttcacagtgc tgttagtata aattcacaac 1742461 ctttgtattt cttttatcga gatgtcttcc ctaacgtgct atacgcaatg cgctaataaa 1742521 aggtttcaaa aatgacgttc ttttattaga taatacgctg gctgaaaacg cctctcctga 1742581 ttggccaaag cgcgaatgaa aaaagtgcat gaatacctgc ccaacagaca gaataagaag 1742641 agttgatatt tcaacacttt tcgtaaaggg gtgaaaccaa tgagtaagaa aggtattcaa 1742701 aattcaagta ttgaacaaat aagaaatgac catgagactg aaacagcttt taaagcagat 1742761 gatcctaaaa aacacggttc cgatcctaaa agaacgaaat aagttcttac ccccactaaa 1742821 atatcaataa tctggaggaa gtaaagtgac tcaaaaaaac ggtgcagaca gacctgatga 1742881 ttataaaaga ttttcttcat tagacaagga atatgatttt cagcaatcta tacgcagcaa 1742941 tactgagaca gaaagtgtaa acactgaaac acaaactcat aacaaagaaa acaaaaatga 1743001 cacaacagat gttgccggga aatactttga gccctcagat tataaaggaa gcacgcaatt 1743061 agaaaaagga ttggctgaaa ctcatgaaca ggtcagcgat gactattttg aagggacaat 1743121 cgatcaaaat ttggactagc catacaaacg gaactaactt aaaagaagtc agttaactct 1743181 gtttttagaa acaaccacag taaaagtagc caacccccac cgaataagat gggggttgca 1743241 cgtaagtagc ctgtttaata tttaaaacga ttaatgacgg tttgaagttc ttctgccaac 1743301 tgagatagag attctgcggc ataggagatt tcccccattg aatgaagctg ttcctgtgat 1743361 gaatttgcaa ccgcttctgt atttgctgac gtttcttttg taccagcagc caatgtatga 1743421 actgtgtgct gaatcacttc aacgcctgaa gtaagctgtt gagttgctgc tgcaacttct 1743481 tgtatttgag aagtgacctg ttccaccagg ttcagtattt cattgaaatt tcctgttgtc 1743541 tcttgagaaa gaacaatacc tgagctcaca ttttcttgaa caactttaat attatttacc 1743601 gtttctatcg attcgttttg gatggtcgct accaccgatt ggatgtggtt tgcagattta 1743661 tttgtttcat ccgccaactt ccgaacttct tctgccacca cagcaaatcc ttttccttgc 1743721 tctccggctc tggccgcctc gatcgctgca tttagtgcca acaaatttgt ctgctctgaa 1743781 atcgtcgtga taagcgaaga gatatcgctg atttctgctg tgctcgctac caatgtttgc 1743841 aatccattgc cggctgaatc tacagattta tcaatgaatt tcatctggtc taacatcttg 1743901 ttgacggact tagagcctat ttcagccttg tctctcatcg aagaagaaag atccgctatg 1743961 ttccctgtat ttgaagcgac tgatgatata ctgtctaata attcagtgat ggattctgcg 1744021 ctcttttctg tcattgagct ttgcttcaca ttgctgtcgg cagccatctg catggctcgt 1744081 gaaatatgtt cagatgttga tttcgattct tccgcgcttg ccgataattc ttcagaggaa 1744141 gcggcgactt gttcagatga gctgctgatc tgcttcacaa tttgagttaa tgaatgagta 1744201 aaagaattaa aagattgggc aagctggcca aattcatctt tatttttcac aatgactttt 1744261 ttggttaaat cagcctcgcc gtgtgcaatt tcctccagct gcttatttat gcttcttagt 1744321 ggcaccataa tggactttaa cagcattatg cttagaacaa tgcctaatat tactgatatc 1744381 cctgtgacaa tgataatgag cgattgactc attttcccat tgccctgtat ttcatccttt 1744441 agatcctcta cctcttgatc caggcgatca gacagcttat tgacagccgg agctacgcct 1744501 tcttttctta ttgttctttc ttctccaaaa tggatggttt ctgctttttt aggatttgaa 1744561 gagtaggctg ttactacttg ctgattcaaa gctctatact gagtaaaact tgtcttaatg 1744621 tcttcaatat tggattgata cttctcttca tcaatcaagt cattaacccg gtcaaggctc 1744681 tttaagacat cgtctgcttt tcccttcata ccctcgtcgt attctttgtc tctggtaatc 1744741 aagaagcctc tttcatcatt tgataacccg gtcaattcat attggatgtg ttttatctct 1744801 ttttggaatt ccattttgtc tttaagttct tcattctttt tcacagtaga agaaatcata 1744861 aatactgagg agcctccaat tccaataatt gaaacaacta atattgatat aatccccagc 1744921 aattttgttt tcactttcat gtgtcgtttt ccctttccgc acaatgtaat ggctgaaata 1744981 aaatatgttc aagcgcgttt gaatccaatt cgcttacgct catgtccata atatcgacac 1745041 gtgttatcaa gttttatagt gatattctta tatgaataag caaattcttt acgtctctga 1745101 acttacagaa aaaccttaag taaaatttgc agtcttttgc ggtatgtaag tcactcttat 1745161 tcgtttttct aaaaaaggct tttcccacct caaattggct gaaccggctg ttttctcgaa 1745221 aatataatac aatacgcagc ataatatgaa ggagcgaaac ttaaatgggg atcatcaatg 1745281 gtaaagaatt cattgaccga ttgaataaac tagaaaacga aatatggtat gatggcgaaa 1745341 aaataaaggg taacatttct gagcatcctg catttaaagg aataatcaaa acaaaaagct 1745401 cactttatga attgcaaaca aaggatgagt taatacatga aatgacttat tgccttcctg 1745461 gagatcataa tcgaatcggc ctttcctatc tccagcctaa aacaaaaaat gatttgaaaa 1745521 aaagaaggac catgattgaa cattgggcta gacatactca tggaatgatg gggagaagtc 1745581 cggattacat gaatacggtt atgatgagct ttgcttcgtc agcggagctt ctaaaagata 1745641 aagagaattg ctttcctgaa catatactag atatgtatga acaagctgct aagcatgacc 1745701 tttcctttac ccatacattc attactccgc aagtgaaccg gtcacagtcc tattttgggc 1745761 taagtgaaaa accgatatct gctaaagtca ttgatagaac cgaaaaaggt ttaatgattc 1745821 atggcgcacg actgcttgcc acacaaggcg ggttgaccga tgaaatcttg gttttttcag 1745881 cgcctaaatt tttctttgaa acagatgaag cttatgcttt ttcaatccct tctaatacaa 1745941 aaggcgtaaa attcatcaca agagaatcat ttgtattaag cgactcttcc tttaatcatc 1746001 ccttaagctc aaggtatgaa gaaatggatt caattgtggt ttttgatcat gtgttagtgc 1746061 cgtggaatcg tgtgtttttt tacgataatg tggaagcagc taaagatttt atgacaaaaa 1746121 gctcttttca tgcctttacc tttcaccagg ttgtcattag gcaaatgata aaaattgaat 1746181 ttctattagg tgttgcacag cttcttgtcg acaccattaa tgtttccgaa tatcagcaca 1746241 tccaagaaaa gctctcagaa atcattgtgg gattggaaac aatcaaagcc ctcattgaca 1746301 aatcggaaaa tgatgctcag ttagatgaat tcggctatat gcgcccctgt ttaattcctc 1746361 ttcaagtcat cagtacgatc attcctaagc tatatcctcg atttactgaa atcatacaat 1746421 taattggagc tagcggaatg gtgacactgc ctaccgaaaa tgcatttgac tcagagatac 1746481 gggaagatct tgaccaatat cttcaagcaa ccaatacaaa tgctgaagaa cgtgtgaaaa 1746541 ttttccgttt ggcatgggat ttaacaatga gttcattcgg aactagacaa actcactacg 1746601 aaagatattt tttcggagat cctattcgga tttcaagcag gctgtatacc agttatccaa 1746661 agcaggagca gttgaacatg attaaaacat ttttacatgc agatacagaa cattgaaaaa 1746721 acagcgggaa aagatccgct gtttcgtatt ttttattcag gaaactgaac atggcccggt 1746781 actgtatagg ctttggacgt tccgctttca ggcagctttg gaatggtgtc tttcacaact 1746841 tttccgcgga tgtcagtcat tctgactttg agagagccag tacctaaatt cgtactcaca 1746901 aaatggttat agtccatttt ctccatgttg atccacttac catccttttc atattccatt 1746961 ttcataacag gatacttgtg atttctgact tggattgctg cccaccacct gctgctgcct 1747021 tctttgatcc ggtacgtgaa attgccggtg attggggctt tgacaacacg ccatttaata 1747081 ttgatttttc cgtctttcat attgccgatt ttacggaagg cattaggtga cagatcaaga 1747141 gctccccgag cgccttcggg ataaagatca gtaacatata cggttgtttt cccttttggc 1747201 ccttcaactt ccaaataaga gccggcaagt gccgctttta ctcctccgta attgagatcc 1747261 gccggattta ttgcagtaat ctccatatcg gaaggaatgg gatccagcag gaaagctcct 1747321 cctgaatagc ctgaccctgt atacgttgca taaccttcat gcaggtcgtc atatgctgcc 1747381 gaagcttgcg gggaaaaaca gaagatcgtc aacaaaacca taccaacaaa tgcactcatg 1747441 atctttttca tatttggtcc tcctcaaacc agacttcaaa tgagaatcat tatcattata 1747501 agactcaatc catctggttt gaaagaggaa atagattcat agttgatttt aaggcaaatt 1747561 cactatcatt catatatcaa atgtaggtac ttatgaaaaa gccaatacaa atgaacgaat 1747621 gtgcacttca gccgaatgtc ttatttttcc ctctcaaaat tcgcatttca ataacgaaat 1747681 gaaacaggct gttggcctga taacagctat acaggaaaag ctatttttcc ccgctcagtt 1747741 tcaacttagc tgtcatcatg atgccaaaga tcagcacaat cggaacccaa ataatgaagt 1747801 gataaaaatc aggctcagcc agagcaacaa taatagcccc tacacaatac aaaataatag 1747861 ccagtgctct taacacagta tctcttaaga aagtcttctt ttgcttctta aaaaacaaac 1747921 ggccggatat atcctctaaa agagaagcca aagtgccggt caacacagtt gaagaaatac 1747981 ctgcaatccc cagttttttt gctgctgtag tttgaatccc catagaaatg ctcatgagta 1748041 taattagaat gtgcacagga acaaatgccc ggtaaaaaga aagacaagca aagacaaaca 1748101 aaatgaatgc ttcaagtgcg agggcttttg tcacagcaga aggccaaagg gtattttccg 1748161 cctttccgac catcaatgta gcaatgatca cgccgcatat aaatccgatt agcgcagtca 1748221 aggaattaaa aacagtgacc tgaatggatt tgccgatagc taaccccaat aatacaatgt 1748281 ttccagtcat attagctgtg aacacatgtc ccaggcttaa atacccgatt acatccacga 1748341 ttccagctgt taaacataaa agtgatagca aggtgtttcg ataagctgct gcagtcaacg 1748401 gtgtatcaat cctttcttct atttcaattg ttagtatgtc ttttggcgca atctctattt 1748461 tttaagtaac ccaacattaa ttaggaagat agaacctatt attcctttcc attaactgta 1748521 ataataatcc ccgcaaggaa atgattaaaa ttgaaaggaa gcatattgtg atgaaacgac 1748581 tttgtttatg gttcaccgtc tttagcttgt ttttggttct cttgcctgga aaagcattag 1748641 gtgcagtcga ttttccgaat acctcaacaa atggcctttt aggttttgcc ggaaatgcca 1748701 aaaatgaaaa aggcatctct aaaacgggca caacgggtgg aaaaaacggg cagattgttt 1748761 acattcaaag cgtaaatgat ttaaaaaccc atctaggagg atccactccg aaaattttag 1748821 tgcttcaaaa tgatctttcc gcatctgcga aaacaacagt taccattggc tcaaataaaa 1748881 cactcgtggg ctcttacgcg aaaaaaacgc tgaaaaatat ttatttaaca acttcatcag 1748941 cttttggaaa tgtcattttt caaaatttaa cgtttgaaca cagtccgcag attaacggaa 1749001 ataatgatat ccagctttat ttagattccg gtatgaacta ttggattgat cacgtcacat 1749061 tctcaggtca tagctataat gcaagcggaa gcgatttgga caaactcgtg tatatcggaa 1749121 aatccgcaga ttatatcacg atcagcaact caaaatttgc gaatcataaa tacggtttga 1749181 ttttaggata cccggatgat tctcagcatc aatatgacgg ctacccccac atgacaatcg 1749241 ccaataatta ttttgagaac ttgtatgtta gaggcccagg tctgatgaga tacggttact 1749301 ttcatgttaa aaacaattac agcaataatt ttaaccaggc gattacaatt gctacaaaag 1749361 caaaaatata ttccgaatat aattactttg ggaaaggcag tgaaaaaggc ggcatccttg 1749421 acgacaaggg cactggttat ttcaaagaca taggcagcta tccatcactc aacaagcaaa 1749481 cctctccgct gacttcttgg aatcctgggt caaactatag ctatcgtgtc caaacgccgg 1749541 aatatacaaa agaatttgtc acgaaatatg ccggatcaca aagtacaact ctggtatttg 1749601 gctactgata taaaagaggc cctgcgttaa aaacgctgtg cctcttttta tactataggc 1749661 tatttttaag cgatccttgt aattccatca agatccagcg tcggtcaaac taaaaagcat 1749721 atgttctttt ccacaataac ttcttaactg gctttcttat tataccagtt tatcgcaagt 1749781 gaaaagaaat cattgttctg aacctgtatt aaatgaacga tcgtcccaca aactacttaa 1749841 aaacccctaa aaaggatgat ggatatgtgc ggcaggttta ctttgtactc tgcatttgat 1749901 gatattattg accagtttga catcgatcaa ttttttccta aaggtgaata ccagccaagc 1749961 tataatgtcg caccatcaca aaacatcctt gcaatcatca atgatggatc aaataatcgc 1750021 ttaggcaagc ttagatgggg acttattcca ccttgggcaa aagatgaaaa gatcggttat 1750081 aaaatgatca atgctcgagc cgaaacaatt accgagaaac cggcctttcg aagaccgctt 1750141 gtcagcaaac gctgcatcat accagcagac agtttttatg aatggaaacg gcttgattcc 1750201 aaaaccaaaa tcccaatgcg gatcaaattg aaatcatctg ctctttttgc gtttgctggc 1750261 ttatatgaaa agtggagcac acatcaagga taccctcttt atacctgcac catcataaca 1750321 actgagccta atgagttcat gaaagatata cacgaccgaa tgccggttat attggcccat 1750381 gatcatgaaa aggagtggct taaccccaaa aatacaagcc ctgattatct gcaaagtttg 1750441 ctgctgcctt atgatgctga tgacatggaa gcataccagg tttcatcatt agtaaattca 1750501 cccaaaaata attcagctga gcttcttgat gcagaaaatc atatgtagtg attgaaaaaa 1750561 ttctctagca agaacttgtc aaatagcttt gttccttagg tgccaatccc tctagtaatt 1750621 atgaatattt agtacataga tcaattagtt atctttagca tcagtttgaa ataattttat 1750681 tatgtaaact taaataagca atgttattcc tttcatataa aatagtttac atttttataa 1750741 aatcgcttca cttttctatt ttgtcagcaa aaaaactgaa ccacattaaa cttatgaaac 1750801 ctgccgcacc tgtggattgc aaatatgata taagcccata gaggtaaatc catacacttt 1750861 ccctcctaag aattaaatga aatttctttc atcttacatg aaggtcttct ttcttttgtt 1750921 tatccagtgt aatacttaat aatatgttga tgaatgcagc tggaaaatat ataaatccca 1750981 ctccaagaat gcctagtatc gtacttaaac ttactatgta attctttgtc atcgtttgac 1751041 tgtcaatcaa tattagaagt gaaatcaatc cagctaaaac acctataaac caagcatcgc 1751101 caacagcata agaatcatcc agcatcccta accatcgccc caatatagag ctcccaatgg 1751161 cagtcaaact ggataaaaat atgagtgctt tcatttcttc tcctccttta aagccaatca 1751221 aactggtaga aatcggccat tgaatcccca ttatcgaatg gttaccattt catttccaca 1751281 ttaacatttt aaagctcatt acaatacgat tcaagcagaa aaaccctaca taacgtatat 1751341 atagggattt aataaaacac aggccaaaat tcagctctat ctactttaaa aagatatgaa 1751401 gggcagctgt gtgatctgtt acgtctttac gtaccgggat atttcacaac aggcactttc 1751461 ttcttgcgca gagaatcaag catgactgat ccagcattca agttgctttg tactaattct 1751521 ttaggcgtca atgccatcca ctgattgagt gacacatctg catagcggtt acttttgaac 1751581 atttctaaaa accataatgt ttctgtacca gtgttttgta tatagtgtcc ggcattagaa 1751641 ggcacgtatc caacgtcgcc tgctctataa tcaaatgtgc gggcagtccc atttccgata 1751701 aataccgtca ttcgtccctg tcctgttaga taatattgcc actcatcgct attgggatgc 1751761 caatgaagct ctctcatcgc gccaggctca atctgaacaa gtgcagcggc tatcgttttt 1751821 gaaattggga agttagaaga atccacaatt cgtacactcc cccctggcat ttgaattggg 1751881 ggttgattta acagctcgtg tttaaaggtc atggggactt ttccatatgg tgactgaatg 1751941 tcttcactgg cgactgatcc cggcacattc ccttggtaga tatagacttg ctcagacgga 1752001 agagagttga aagcattctc cgggacaccg aaatttgcag acagaacatc ttttggtgtg 1752061 tgtgcaagcc aatctgaaat ggttaacgtt gaaaactcag aaaagttccc atcatcgaaa 1752121 acgagcagaa actcgcagtg ttccaatccc tgtatggaat gcggaattcc tgccgggaag 1752181 taccaaaggt cgccgggacc aacatcagca atgaaatttc gtccgtcttg gtcaacagcg 1752241 gtgatacgtg cccgtcccaa aagcatataa gcccactccg cttgcttatg ccaatgaagc 1752301 tcgcggacgc ctcccgcagt taagctcatg tttacacctg caatcgcagt cgaaatcgga 1752361 agctgtctta cggtgatttc tcttgaccag ccgccgtgat ctaatttcat gggagcgtct 1752421 gagaatgaaa atctcaagtt aggaatcata ccctcatctg taacaggcgg aacaaatata 1752481 ttcggatttt gaatatcccg tattatattt cgcgggcctg tatcaatagc tccagctcca 1752541 tcacttcgaa taggctgcgg cacgtttctg tcttcatgat tgattggttg ttgttccaac 1752601 agcatgcacc tcgttttaga aatgaacaag attttatttc agcctatgca gaatcttaga 1752661 ttgctgtgcc taggaatccg caaataaaaa agtgaccacc aatgtgatca caaatacatc 1752721 aaataaacta ttttttatac catggcttct tatgtaattt gattgcttct gtctgttttt 1752781 tctggcctgt cctccactcc acttttacta atacatcatg acctatcact tcatcttcag 1752841 gcatataatc aaaggtggaa atatggtcct ccatgcgtcc cccacccggc atttcatcac 1752901 ctgtgtactc cgataagtcg tactcatcta cgttatcatc ttgatacttt tcgccatcta 1752961 catacagagt aattctttca acaacagtcc acttttcttc cttcttactc ccctgccaat 1753021 atagatttag aaaataattg ggtccaattg aagttttgtc tgatttttca aggttagaca 1753081 tccacagtcc gcttttcccg ctgccctcat atttcacttt gttccctgac accattacaa 1753141 ataatgtgat gatgcagatg atcaagaatc cagcaatgat caatagccat ttcttaatat 1753201 tgttcttttt tctcatgttt ttcctcactt tcctaacttt ttagtaggaa aatacgatca 1753261 aaatgttacc gaaaagaaaa taagaaaggg ctaatgatct aacagatgac tgtctaaact 1753321 tttgacttaa attaaagtgc tttctaaaga caagattaaa acgtataaca gctcttaaat 1753381 gcattttttg tttcattgag tcaagaacct taaaatggct ttttattatt aaaaatcaag 1753441 ctagtgtatt aagtaacttt tcaaatttat ttatactcat gatctcgtga gtcacaaatc 1753501 tcccatcaaa aaaaacgcta aaagttgtcc aaatagctgg tgacttttgt gcctcttctt 1753561 tcgatgataa ctgaattgac tgaaattgaa cccctttctt ttcagtcaat tcccgcaaat 1753621 catttatcat gcccactgca aacggacact gagctgtata gtatatcgta atcccctttt 1753681 cattgataga atcacttttc acctggctct taaatgcagg agaatctgca aggccattcc 1753741 aagtcaaagc cattaattga aaataagggg cagcttcatc ttgtagagta aaccccatat 1753801 gctcaaagaa atgcttatca cttaaatagg gcagtttttt cttgcctgcg atatggataa 1753861 tgccatccat gccgcacgct ttcgcatctg ctatacattt gtccaacaat cgtttcgcat 1753921 gaccgttatt tttatatctg ccagacaccc acagacaatt aatgtacata aaattaggcg 1753981 cattgatagg cacccatgcc tcattcgcag gtaggtattc aataaagact tttgcccgtt 1754041 catgtaagcg atagaacacc aatccttcat ccattcgagc tttgagccat ctcttctttt 1754101 cattaactgc atgctcatat tgtttcgtgc ttaatgcaca gcaaatatga ttgtcttcaa 1754161 tattgtcctt tgtgatttca atgtagcaca tctcctcttt ccccccttta acataattac 1754221 atggaattca acttcacact ttacatgcct aatagaataa atacccgttc caacttaaat 1754281 actttttctt ttccattttg ccaattaact gtaaaaccct tcttttattc agatattatc 1754341 ttgattccta tatcacccat ttcaaatcca aagtgtgttc atctttgagg attagatgca 1754401 ctgcttatgc tataaataca gtacacgaag ttttttattt gaagtaatat ttgttacggg 1754461 acagcaatag taaataagtg ataaaagggg aattaaactt ggtggaaaaa tgttattctt 1754521 gtttaatttg cggatacaaa ggattaattc aaaatccttt gtataaaggc gagtatcaaa 1754581 aaacgtttga catttgtcca tgttgcggtt ttgaatttgg ctacagtgag gatcatgatg 1754641 tgaggttagg ttttattgta actcctgatc atttaattga ggctgcattt caattgtatc 1754701 gcaaacaatg gcttgagagc gggatggtaa ttgctcatcc ggaagatatt ccagaagaat 1754761 tgaaaaatgg caattgctta aaatttgaag ttttgttgaa acaattgaaa aaactaaatc 1754821 ttgacataga aaattttgaa attagcggtt tttaatgatg aaacaggttg cacttgttta 1754881 ggtttcactg tcattatcag taaaatgtta agttgaaatg cgcaatcagt cacaaagtct 1754941 ctattcgtat tcaataaaga ctttgtgatc atcgacaaac atttcactcc catcggataa 1755001 agtatccaaa aggcctcctc tggttcttct ctatagtcat taatcacagt cactttgaca 1755061 tttgactcag ctatgattgg ttttccaaca atttttcgtt ttttcctcag gcaaagtaag 1755121 agatcgaatc atcaaagcca ttccatcttt actgtctaat taacgccatc ttcagtgaat 1755181 ttaaaggtct gttttaaatt gcgtccttct tgccccttct gtgtccaaat tataacaacc 1755241 tctaattcag aggccttatc tgccagcata aaatgattga acttcagcgg tgagccatca 1755301 tttaaacttt cagctaacat tttagaatct tcttttggtt tgacacaatt ttcatcggga 1755361 catccaaaaa gcgaaaacct tgtgattgaa ttagggtcat ttctatacaa ttgcacatcc 1755421 actgtagctg ctttttcccc tatatttttg acttccaagg aatatacttg atattctcct 1755481 ttatgaggtc tcgtaaattc ctttacattt tttgcttcac ttacttttac tgaccactgg 1755541 tctgtttttt gtgtaatagg caacaccgta aaagtcaggg catgcgcttt tgattggcaa 1755601 aacgtaaatc caactgctgt aaaaacaatt acagaaaata ataccctttt cacttcattt 1755661 atccctcctt cctttcactg gccgctcctt aaagaattga ttttgagcaa tctacaagct 1755721 ctcttaacca aaaccttacc tgaggttttg tctttactgc tctgcattta tttctttcgg 1755781 tatccgagaa ggagctttgg ggatttttct caatctgctg ttaatcacat cagaagagta 1755841 tagcgtaata atcatacttc ccccatacct ttttgcccga attaagattg gttggttata 1755901 ttggttttga aagcgaaagt caggacctcc ccagcttacc gtcgcatccc gtccgggcgg 1755961 tacatatggt acacttctag tatgagaata gcgctgaacg atctgcagtc ctgcacgatc 1756021 tactgcatta aatagagttg aggacacctg acaaattcct cctcctacac cttcagacaa 1756081 ctcccctttt acaataatgg gtgcactttt atatcctttg ttccgagttc tcattcccac 1756141 aacttggtta aacgaaaacg tctcattagg gaaaacaacg tgattgtcga ttgcttttgc 1756201 agaaagagaa atattgtgtg aacggctttt attgcttgag ttaaaatacg tcacgtactg 1756261 accaagctgc tgcgtactga tgtgagctag cagctcgctg tcaactttcg gataaatgtt 1756321 catttccggc acttctatct tggagggacc ttgcccataa aaatacgcat aaaacttttc 1756381 cataaacgcc tgttgataca gtttgtagcc aaccctgccc gggacgatgc ttccatgatc 1756441 gttaaggaca gcatttatcg gctcacggta cactttctga tcaagctgtt tgatgaattt 1756501 actgtatttt tcatagtcaa ccattggagt gccgggaaga ggcattgtaa agtcttcacg 1756561 gttaacagtg gcaatcgtcc gtccttgctg tgtgaccgtt aaactgtcct gcggctcact 1756621 cggctgagcc aataaaaaaa gaccagtgat caaaatttgt atcataagtc ggtttacctc 1756681 ccaatcatta gtatgaacag ccgcttatcc tttgatgtat ttcttcccat cgtttgtttg 1756741 aatctttaga cgttgataaa aaccttcata aaagagctta gctttatgtt cacaccgatc 1756801 cctgagctca ctgaggcaca cggttcattc agtcggcaag tttgaagtag ttcagcatct 1756861 cccagtgatg agggatgctt ttttgtcttg tcaaaaatga aaagggtctc ctataacaac 1756921 aaaaaatcaa tccatttcaa tattttttta ttgagaaacg ataaattttt tgttacattc 1756981 aattagacaa caaataaatg aggtgcttgt tatgaatcga atgtcgacaa tttttttaaa 1757041 gatagctttg gttcttattg gaattccaat tcttgcttta tgcatttttt tagtgcctaa 1757101 ggtagccaac tattcagcag aattatttcc aaatatcgct tatataaaat atctcgtttt 1757161 catctatttg tatgtaacgg cgataccttt ttactttgct ctttatcaag cgttcaaact 1757221 tttaagctat attgacaaaa acaaagcttt ctcgggtttg tctgtaagag ctttgaagaa 1757281 tataaaatat tgcgcagtca ctatcagtat cttttacgca gcaggcatgc ctgtctttta 1757341 tctgatggcc gagatagacg acgccccggg tatcattgtg atcggattgg ttattatttt 1757401 tgcttcaatg gtgattgcgg tctttgctgc tgttcttcaa aaactgttaa aagaagcgat 1757461 tgatataaaa tcagaaaatg acttaacggt ctgaggtgat gacatggcga ttattatcaa 1757521 cattgatgtg atgcttgcta agaggaaaat gagcgtaaca gagctttcag agagagttgg 1757581 catcaccatg gctaatcttt cgatattaaa aaacggaaaa gcaaaggcta ttcgattatc 1757641 aactttagaa gcgatttgca aggctttaga atgtcagccc ggggatatat tggaataccg 1757701 aagtgatgaa gacacaggat tcgtaaagaa aaaatatgaa ggatcaacag aaaaataaag 1757761 tgattggcgg tgagcttatg gacataaact tatatccatc tagctgctat actaagcgtc 1757821 cctttcatac acgaagaaca caactatgga ggaggcatac atcatgagag ccataaaaca 1757881 aatcgtccat tttggctggg aacaagccct ttcatgtttg tttcctgccg ttatttttgc 1757941 ctctttggct attacgcaaa tcatcccact gcccttcttg ccgcggtatg actggctgct 1758001 cattatctgc gttctcatgc aattgtggat ggtgcgttcc ggtcttgaga cacgggatga 1758061 attaaaagtg atcacattat tccaccttat tgggcttgct ctggaacttt ttaaagtcca 1758121 tatgggctcc tggtcttatc cagaagaagg atactccaaa atatttggag tacctttgta 1758181 tagcggcttt atgtacgcaa gtgtagccag ttatttgtgc caggcatgga gaaggcttaa 1758241 ggttgaactg gttaagtggc cgtctttttt tgcagttgtt ccgcttgccg cagcgattta 1758301 tttgaatttt ttcacccacc atttttctat agacattcga tggtggttat cagggcttgt 1758361 catcattgtc ttttggcaaa catgggttac atacgaggtg aatggagctc gttaccgtat 1758421 gccgctcgca ctttctttta tactcatcgg attttttata tggatagcgg aaaatatcgc 1758481 tacgtttttt ggagcttgga aatatccaaa ccaaatcgat acatggagtc tcgtacacct 1758541 tggaaaggta agttcatggc tcttgctagt gattgttagc tttcttatag tagcatcatt 1758601 aaaacaagtt aaggagcaga gtcccacaaa ggcagagatg gatgaatctt tttcttagca 1758661 tacgcataca agctcccaaa tagagtgaaa agcaacgttc aaatggttgc ttttttcttt 1758721 tatgtaactc tgccggtgag tattcatctt cttcaaattt catcgcaaca cgataactga 1758781 ttcagattac aactgctttc aacactttga caaactcatg cgccgccggc gttatctctt 1758841 caaatgaatg tgcgatgacg ccaatatcgc gtgtgaccct aggaaagatg tcctttttaa 1758901 tcaattgatg cgggacggat gaaagtgtaa agtttgaaat gatgccgata cccaagttat 1758961 ttttgaccat attaatcaag gtttcggcat tttgcacagt taagttttcc tttaattcga 1759021 tgttgtattg cgaaaatgcg tttgacatcg cgatttcatg accgccttta caaaaaatga 1759081 ggtcatcttg atatgtttca aggtcgacat gcttttcaag ttttaattcg tcacgctgcg 1759141 gcgggatgac ggccaccata tagtcgttac acaatagctg attttcaaac ggttcaaatg 1759201 gagatgctgc gatcccgata tcaaccgtcc gatcttcaac ccatcctttt atttggtcag 1759261 aggttccttc gatcaattct atgcggatca gcgggtagtt tgatctgaat gccgcaatcg 1759321 cctgtggcat gatatttgtt gaaactgcag gaaatgaacc aattttcacc ttcccgttta 1759381 acagcttgtt ttcccggttg gctacttgat atattttgct ttcaattccc ttcatttgcc 1759441 tcgccagcag caatatttct tttccgatgt cagtcagcat taaaccatga tgtttatccc 1759501 tgatcaataa tttgagctgc agtgagctct ccaggttttt tatcgcttta cttaccgccg 1759561 gctgagagat gaacaattct tttgccgctt ctgtaatatt taatttctcc ccaactttta 1759621 caaatatgtg aagatggttc atgttcataa ccatttggtt atacccccaa taataaaaat 1759681 gtatttcagt tatacataaa tgtaacatat gatagaaacc agcacgatat tttaacaaga 1759741 aaggcggctt cattatggta aaagttatgc tgggaatcat atctgtcaca cttatttggg 1759801 gttatacttg ggttgcgatg aaagtaggaa ttcatgacat ccccccgctt ttattttcgg 1759861 gtttgcgcct gttcatcgga gcagttcctt tatttctcat tctcttcatc caaagaaaaa 1759921 agctttcaat tcaaaaagaa catctcaaaa gctatatcat catgagcctg ttgatggggc 1759981 tgggctatat ggggattttg acgtatggaa tgcagtttgt cgattcaggg aaaacctctg 1760041 ttttggtata tacaatgcct atatttgtta cggtgatcag ccatttttca ttaaacgaga 1760101 aaatgaatgt gtataaaacg atgggactgg tctgcggcct cttcggactg ttatttatat 1760161 ttggaaagga aatgctcaat atcgatcaaa gcgctttatt tggggagctg tgcgtacttg 1760221 tggcagcgct tagctgggga atcgcgaatg tgttcagcaa gctacaattc aagcatatcg 1760281 atattattca catgaatgcc tggcacctta tgatgggagc cgtcatgtta ttggtgtttt 1760341 cctttatatt tgaggcggtc ccttcagccg agtggacata tcaggcggtg tggtcattgc 1760401 tgtttaatgg cttgctttcc accggcttta cctttgtcgt atggttttgg gtgctcaatc 1760461 aaatccaagc gtcaaaagca tccatggcat taatgtttgt tcccgtattg gccctattct 1760521 ttggatggct gcaattgcac gaacagatca ccatcaatat tatcctcggc gcactgctga 1760581 tatgctgcgg gatttttatg aatacattta cattttcacg acggaaagtg tgaatgatat 1760641 acatttcccc tgtcatttgg gcttcatgtg acaggagaag actattacga gaaagtcttc 1760701 tagaatcctg acgacagcct attaaacaat gaaaaaagct aatgtctgca tgtagacatt 1760761 agcttggctg gcgtttaggc tggtgagaat ccagatactt ttttattacc attctggctg 1760821 atcaaactga aaaccgtata gaccttttac tttaacatct ccgcaatctg gatcttttgt 1760881 caaaatcaaa taatgagtct tataaggcat cgtctcaact cgatcagttg cactaaaatc 1760941 aaaatgatcc cccgagaagt ttttttcact aacggttatt tcatatcctg acaaagtcat 1761001 tcgcatgatt cttgcgttaa ttgtacatcc ttcagtatcg aaaatggtga atctgtaccc 1761061 aaagtgagat gtccaatggt ttgaatttag gtcatcagac ttcataaacc atttttcatt 1761121 ctctgtcatt gtaaaactca ctttctcctc atctttcacg ataacggccg aagcttcccc 1761181 tacatggata gtcaaagcca aaagaaatgt aaaagctaac atcaacatct ttttcaaaag 1761241 agttcctccc gatatctttt acttcaatat attggaaggg tcttttctga tcaagacagt 1761301 cttctccaaa tgaatcttta gcaccatgaa atgagcctta ataagaacag ttttaaccca 1761361 aatcaacctc tattcgaaat aaggcttacc aatctatatt ctttttaaaa gtttctgcat 1761421 ttctttattt agctcctaga cacatataaa aaatgctcct ataagttcag gagcactaca 1761481 aaaaactgct aaagtgtttt ctatcgattt attgtattca ttagctcaaa gaaatattca 1761541 ggcttttgag tcttatttag cttataccat gaacgcaatg tatctggtgc aaatacatct 1761601 aattttttca atacttctac cgcaaattcc agaggagcaa ttcctgatgc agtaaccaaa 1761661 ttttcatcag atactgcagg ccccttttca tagaatgttt ctcctttgta attagggcag 1761721 accatattca tatagtcgag gtcattgctt gtgtgctttc tcgaatttaa gtatccttca 1761781 ttcgcgaggc ccaaggttgc cccacaaatt gcagcaatag tcgtgccgag ctttaaagcg 1761841 tcgccaactt ttttcaagat cggctgatga atatcttctc cccaagtgtt tcctccgggt 1761901 aaaatgataa gatcttgact cccaagagta cattcgtcaa gagaaatatc tggttttatg 1761961 cttaatcctc ccaacgtagt tatcatttct ttattaaccc ctactgtaac tacttttaaa 1762021 gatgctgcat cttgtttaaa gtatctccct gagtttagtt ccgcaattaa atatccatat 1762081 tcccagtctg acattgtgtg aaatacgtag agataaactt ttctcgtttg catccaataa 1762141 cactccaatc acaattgata aagctttcta atagatgact ttgctgacag tcattgtcag 1762201 cttttttgtt gattctattc ttatgccctt gttctcccaa cttataaaaa tataagatca 1762261 attgattcta tgtttactag cgcaaagggg tttgttacac taactgtcat gggaaacatt 1762321 tcaaaggtaa tacaaaatca tttgaatgag gaggcctgat gaagttgaaa actaaagcgt 1762381 caataaaatt cggaatatgt gttgggcttt tatgtttaag cattactggt ttcacacctt 1762441 ttttcaactc aacacatgcc gaagcaaaat ccatagaaga cacaaacatg gcaagctgta 1762501 taacgaataa aaaatttgtt caacttgaga aaaaatttga tgccaggctt ggtgtttatg 1762561 caattgatat aggttcaaac aagacaatcg cctatcggcc gaatgaacga tttgcttacg 1762621 catcaaccta taaagttcta gccgcagctg ctgtcctgaa gaaaaactca attgaaaaac 1762681 ttaatgaagt catccactac agcaaggacg atcttgttac atattctcca atcacagaga 1762741 aacacctaga tacaggcatg agcctaaaag aaatctcgga agcggctatc cgttacagcg 1762801 ataataccgc tgggaacatc ttgttgcaac agcttggcgg ccctaaaggt tttgaaaagt 1762861 cactgaaaca gattggggat catgtaacga aagctaaacg attcgagacg gatctaaact 1762921 ctgcgattcc tggtgatatt cgtgacacca gcaccgcaaa agcactggca accgatctta 1762981 aagccttcac tttagataac actctcacga ctgacaaacg catgatctta accgattgga 1763041 tgcgaggcaa tgctactggt gacgaactga ttcgggcagg cgctccaata ggatgggaag 1763101 tcggcgataa atccggagcc ggaagttacg ggacacgaaa cgacattgct atcgtttggc 1763161 cgccaaacag agctcctatt gttgtggcaa ttctgtcaaa ccgctttacg aaagatgcta 1763221 attatgataa tgctcttatc gctgaggctg caaaagtcgt ccttaacgat ctcaaataat 1763281 atgtttagcc ttttgccaca aaggaaaaga cattactttt ttaacttcta ccgttcattt 1763341 tttgatgaac ggttctttca taagacctct agaatcatat atttaaacac cacaaaatta 1763401 aacattatta taattaacag caagttttca ttttatggaa caagtaaagt ttgaatctga 1763461 caagaattaa gactaagcac cctaaaatcc gttttctttt cttccaagaa tatactcctt 1763521 agtgcaagcc attataaaga tacaagtgaa catacaatgc agacaactct cttaagtctc 1763581 ttattctgtg accaatttgt aatactcatg aatatccgga ctcacttcca atatttcgtc 1763641 tcgttcgaag acactaacat atcaaaccac ttgaattaac ataactgaac ttgatattgg 1763701 tcactggcag tttcaatgca atagaacaac atttgttgtc tcagaggtta tctatatgag 1763761 aattcaacaa tttttttata ataattcata tttttgtatc gttgcacttg gtggatttga 1763821 ctcttttcgt gtatggaacc acacttttat tttttcacct cttttgagat catctgtgtt 1763881 atcaatctca cttaatccta caattactat gttattttta aacttgttca taagttgtcc 1763941 ttcagaaaga ttgtaatctt cttttcctgg agcttttgta tcggtaatga gaattgccct 1764001 ttcattgtct ttaagcacga catagcctac taggctctgc atctttgttt cgtctccgtt 1764061 ttgttcattt ttattgcagc ctgcaaggaa aataatgagc ataatgagca ctatcaagct 1764121 tactccgatt ttaggcatct ttcttcctcc tctttaaact catctttaaa ataaacaaca 1764181 ggatatcacc caacccatct acttcttttt gcaattcata acagcagcat actcattctc 1764241 caattcctca accttctttt tattctttct caaatatttg catgtggtag ccctcgatat 1764301 tatccgctta ctcatttttg cgctttcaaa tatattattg aaggccgctt ctttctggat 1764361 tccagcataa atatacttat ccttactgtc gtttactatc gcaacttcca ttaaaatcga 1764421 gatttttact ttttttatga tccattattc acttccaaaa taacttccaa ttacaacata 1764481 atatatgtat aaattgtaaa tggagttgat gtaattgaag attaggaaaa tcttattgag 1764541 ttctgcttta tcctttggca tgctaatatc cgcggttccc gcattggctg ctggcacttc 1764601 gtctgaggtt gcagtaaaaa atgaagaata tgattatgac actatatacc gcattagtcc 1764661 tctgccaatg gacttccagc caacaataga atacaacggt tatacttata cgcttacacg 1764721 tcattatttt gattactcaa tcgggtttta cacggctatt tatacaaaag ttgtttaaac 1764781 ttataaagga gctttttagc tcctttttct cttgttttaa gcaaggtatt tctttctatg 1764841 tggtccccta tcaaatacaa catcaacatt ctccagttct ctttgacacg aacaaaatct 1764901 aaagtttggt tttaaatgct ggtaataaaa aattcacttt aaagaagtgc cgcccgcaaa 1764961 atacggcttt tgtacactac gccaatttta tattgaaaag ccagacctcc tcaaagaggt 1765021 tccagctttt cttaatgtgc tatcgatctt cgttagttca acgggaactt tatcattcgg 1765081 tacaaatgca gcctcccaac ttctagttag ggctgatggc ggaatatctg acggttctct 1765141 acacacatca gacattagaa gatttcaatg tagccttctg taccatgaac gcgaattcgt 1765201 tgcccatctt ttatcagctt ggcagcattt tcaacgccaa caactgcagg taagccatat 1765261 tcacgggcta taacagctcc atgggtcatc agccccccaa cttcggtgac taggcctttt 1765321 atggatacaa acaatggtgt ccagcttgga tcggtaaagg aggtaactaa tatatctcca 1765381 tcttctaaat ccgcatcttc catgtttaaa atgacacgcg ctcgcccctc tataactccg 1765441 gaggaaacag gtagacctac aatcgctccg gctgggagat tttctcgttt atactcacct 1765501 gtaacgattt caccatcaga cgtgataaca cgtggtggag atagtttttc atataatgtg 1765561 tactcgtctt ttcgtgtact gatgatttga taatccagtt tatgtgtgcg cacgacttcg 1765621 tgaagttctt caaaagtgag atagtatata tcttcttttt catgaataac gcccgcttct 1765681 atgagttgtt cggcttcttt cagtaaagcc tgcttataaa cgaagtatcg attaaccatg 1765741 ccgtattttg gatattccct aaacccgctg aaattccgga tgatatctat cgctcgtttt 1765801 gtttctttgg ctttttgttc accatccggt aattgcttca atcgatctaa taactcttgt 1765861 tctttcttca aagcttcctg tcgcccttgc tcaaatttcc gatggccgac attaggctca 1765921 aaatttttaa tattattaag aatcattggg acaagtgtag ttggtttttc gctccatcga 1765981 gttcttgtga tatcaatctc tccggtacat cgcattccgt atttgctgag ataatcatag 1766041 atcgcgtctc gggttttgct tccgccatca aacttagcca gttcatccaa aaagttatca 1766101 tcttttacat gttgtaagta atcaattacc tctggataag gacgaatcac atctgcgacg 1766161 tctaatagcg caagacccat ttctgaagta atattatggg gtacagattg agaaagcgta 1766221 tctgctgcgt ttttttcacc taaccactcg ttcatttttt cgttaatcca taatgaagca 1766281 ttcatagcag ttcgaattag aaccgaactt tttgggttaa ataaaatctt ctttaattcc 1766341 tgaatatctt ccagaataaa acgaaataaa tctgatcctg atttcgtttg gatgttttgt 1766401 tttaactctt ctatcgatgt ttgactgctc tcaatcaaat cagacacgat tgtcggatcg 1766461 ttttcaactt gagccggcat atctgcattg cctctgctgg gatttggtgc tgttttatca 1766521 tttggtatcg actttatgaa atctcgtcgc tttattatgg tcataagtgc gtcttttaag 1766581 agctgatcgt gctgccccat gccttttaag aaaacttctc tgctgtcagg ggatgccaga 1766641 tgatgtgtga catcaacaaa tagccttcca ccggctttac gcatgggtgc aacagtcgtc 1766701 aacagaaaaa aagacaatcc cagtggtttt atgggatccg tcatcatttg ttgatgacca 1766761 acagaaatat agacgtgatt ttcttggtca ctcgcttcag ggatggggaa taaagtagtg 1766821 attggacgac tctgtacaat ataaaaagta tcgcgggcca aacaccattc gatatcttgc 1766881 ggctggccga aatgagcttc gatctgtctt ccaatgcgtg ccagctgtaa aatttgttca 1766941 tcagtcagtg tttgagcctt ttgctgatca gaatcgatct gctgtgtttc tgttccgcct 1767001 tcttttcgtc cgtagatagc cattttttta gttgctattc tcttatcgat gatttgccca 1767061 tcctgtactt taaaacaatc ggcagatacc aagccagaaa ccagtgcttc accaagtcca 1767121 aaaccggcat cgatggataa cacctttcgg ttggaggtaa tcggatcagc ggtaaataaa 1767181 atccccgaag cctgagggaa aaccatcctt tgaacgataa cggataaata gacttggctg 1767241 tggtcaaatc cattttgcat acggtaaata accgcgcgat ccgtaaatag ggacgcccag 1767301 catttactga tatgctgcaa gattgcatcg acgccggtaa tatttaaata ggtgtcttgt 1767361 tgaccggcaa aagaagcatg tggtaaatcc tcagcagtcg cactagaacg cacggcatag 1767421 gcatgttcct cgccaaactg ggagagatat tgagccactg ctttcacaac atcggaagga 1767481 atgtctactt ccataatgat ttgccgaatc ttccggctga tgttaccaat ctgatctcgg 1767541 tcctcaactt ttagcatggt caattgatcc aacaacactt gtaacgtttc gttttgttcg 1767601 atggcttttt gatatcctac tgttgtgaca caaaatcctt ctggtacttg tataccttga 1767661 atttttgata attcccctaa atgtaaccct tttcctccaa cgagcgaaag ctgtgttttt 1767721 tcaatttcat gtaaaccgag aaccaaagaa ctcattctac atctcccctt caaaaaaaaa 1767781 tattgacaag agcttcctag caggatataa taaaattata agatggatat ctataacttt 1767841 ttaactagaa agcgcacgta gtgtgattat atcaccgtgt ctgtttttgt gcaatataaa 1767901 aagaacctgg gaaatttcac caggttcttt tcttaatttc catagctagt cgcattaaaa 1767961 aacttggttt gagctgattc aatcctctaa ggaaatccta aagttgggtt ctttttgaac 1768021 ttacttgctt tgttcgtaga gtccccattc ataaattgga ctttttgttc ttaacagtcc 1768081 cacctttaac tagtataaag ttatgaggat ctggttaact actagatatt tttattttga 1768141 ataaggctta tgtttgataa agaagggtta tgtaaaggtg tctgttgtga gcaagcgctg 1768201 actacaaaaa attgatagca ttctcattta aataccattc tattaaccta tagggaaagt 1768261 tttaaaacca gatggagaat accctacctc cagcaattcc aaggccgttc acctagtaga 1768321 aaacaacctt taaccattac taacgatttt aataatcatt gattataaaa cttctcaagg 1768381 aacgatcagc agcccgttag ctacccctga ttaaggatga tctgttacca cactgttacg 1768441 ttagaacttc cactactttg atatccttct gtcgccatga cttggtaagc ccaattactg 1768501 cccagattca ttccatggct cttccatgcg ttcacatgat tgctgaaagt gattgtagcg 1768561 ttgcttccgg ttggtctctt cgactggcga acactccagt actgcgtaaa agtagtgcga 1768621 tcgccatcaa tggaaggtgc gttataacgt gtagttgtat atatgtcata tgtaccccca 1768681 tcacttttta cagtaccttt atacgttcca gtaggtctat aagtacccca tgaatccact 1768741 acataatatt ctatgagagg tgatctcgtc caaccatata aagttaaata tccattgcca 1768801 ttcggcgccc aaactccggc attatagttt atcgtcctaa atggcgaacc tgtagtccaa 1768861 cctttaccaa caacaaaatt tccggtatta gaccaattaa cactgtaatt cccgccagac 1768921 ccattgacag cgtttactat accgccccca tcagtccaat tttgccagta gtctgtgcta 1768981 gctgcagagg cggttgccga aaacaagcta atactcatta aagctgccga taatccaact 1769041 aagaaattct ttttaaactt aaacatatgt tacctcctat aatatttttt ccgactttga 1769101 ggtagcactc gtatacattt aaaacattct taattactaa cgccaaagct tttgatcgtc 1769161 cccttcagta taataccacg aattcatgag caaatattaa aagtatttgt aattcaatta 1769221 caaataccta gaaacacatt ataagtggtc ttcttccacc atatcctgat ccgagctcga 1769281 tgtacatgcc tttacggcac acacgaatgt ggcgtgtggt gcatcgcctc aatacgcaaa 1769341 gacgtttgcc ttaggcaaac gtcttttttt gcgttatccg atttttgtgc cgtttgggac 1769401 aggctgatcc ggctgcaaaa ggacgacgtc gccctggccg ggtatgccgc cgaggaccaa 1769461 gacttccgat ttaaatccgg cgatccggcg gggcggaaag ttcacgactg ctatgacttg 1769521 cttgttgatg agaccttccg gcttgtaacg cttcgtgatt tgtgcgctcg attgttttat 1769581 gccgatttca gtcccaaaat ctatcacaag cttgattgcc ggtactcttg cttcaggaaa 1769641 ttcttccgct tttacaattg ttcccgttct gatatccaat ttctcaaagt catcaataac 1769701 tgccatatca ataactcctt tttctcctat tgtaaaggag atatacaata ttcttttaac 1769761 taaagagcca tcatttttta tccgaatata aggtgtttcg atacaggcgg ggcggcattc 1769821 ctgtgctttt cgtgaaccat cttgtaaaag aagaaaggtt ttgaaagccc agcgcctcgc 1769881 tcacgacggt aagagtttca tttctctcca tcagcattct ttttgcttcc tcaaggcgaa 1769941 ggtcggcaat atagttctgc ggggacttcc ctgtctgttt tttgaaccag cttgaatagt 1770001 aagctgggtg ataatgctcg atttctgcca gcttcttaat cgtcagccgc tcaaataaat 1770061 ggctgtgaat gtatgcaatt gaggcatagc tatgggattg aagcttttct tttatgtatt 1770121 gtactagcat atgaagcgag ttggctgttc cggcctttgc ttcctctgtc agcaagtacc 1770181 tgatcgaaga ccagaaagga tcgagggcag cttcaattcc tgatcctgca cgatactcat 1770241 caattttcat tgcatgaagc ggaacatcca gtacaagaca ttcatttctt ccgatagaac 1770301 ggaagcgatg ctcgcactgc ggcggaatat ataaaaaatg atccggattt aatttcacct 1770361 ggcgcccctc agtctcaaga tcaatactcc cttcaagcgg aaaaagaaat tggctgtacg 1770421 cgtgcttatg tgaatgatat agccgtgtgt atgtccgttt ttcgcaaatt atctcttgaa 1770481 gcgagtccat tagcaaaccc cttcctttgg tcatctttta atccggtaat ggtgttccga 1770541 tataggcgaa aagccgattt ttccatataa agaaactgcc gccagatttt ctttcatcac 1770601 ttgtaaaaac atgcgttccg ctccgttgtt ttttgcccat tcagtcaaca ccctgatcac 1770661 ttgggttcct gccccttttc ctctgtgctc ctcagctaca acgatattac taagtccgcc 1770721 ataaccatca atgacagaaa ccgtgccaag cgctgtcagg ctttctttgt catacatctt 1770781 gaaaaaagtt ttacacggcg gcatgcgttc gaatatgtgt ttgtaacctt tgtgacgctc 1770841 gggtgaaaac ccttctaatt gaataaattc atctatccaa acagatgatg gctcttgttc 1770901 ccacttgtat gtaaatcggc tgttgtcatt tgttcggctc ataattgacc ggcacaacgc 1770961 tgtcatctgg aagcactcgt ctaccttttc ataacggctg tctgccaatg cgtcatcaag 1771021 ccctttcggt gatgcgttgc taatatgaaa acaaacaggt aagcctaaac tttgataaaa 1771081 aagttcggcc tctagctgaa aatccccttc aggcatatcc gcagacgtcc atacgctatt 1771141 tgcccttttg gttacgccaa aattcgctct gagaagccat ttccctatgc ttttttgaaa 1771201 ataagccggc catgaagctg ccgctaatcg ttcaatcttg cgaatgtcat ccattgcata 1771261 atgcctctcc cctatgtata ctcccttgat attatacaat attcagaaat ataagacatc 1771321 catttatttg tttacataat atttttattg tttattaata atcctgacaa aaatgtccga 1771381 attgaaaatg acaggctttc taaaatgtcc tcctcacgtt caaatgcttc ttttgcgatt 1771441 aaaacagtaa agccatgcag cagacttctg agcccccttg tcgcatgaat ggcagtcttt 1771501 tcacttgcat agccgttttc aatgagcagc ttcgtcacaa gacagacaat ttggtcagag 1771561 acgatttccg tccgtttgtc gtgaacctta agaagagccg cttcataata tccgggattt 1771621 tcaattgcaa aatcaacata tgcatgagct aaagaaagca tcgcggaatc tccctttcgt 1771681 tcggttacgg agtccgccat ttgatcaaaa agctttgtca gtcctctgac agcaagttct 1771741 gctctgatcg cttgcagccc gttgatatgg ttatacaatg acggggggcg aacattcatt 1771801 tttttagaaa gtgcagcaag tgagacacca tttacccctt cctgatcggc aatctctgct 1771861 gcagcgtcta caatcatttt ttgggtcaaa cctattctcg gtgacatgct catcatcctt 1771921 tctttgcttt ttggatcgcc tgtctcatcc gctctgaagg tgatcgcagg aattttccat 1771981 gtccgacagc gagacaggaa ggcgccttat cggcgagcaa ttgtgcactt ttgatggcct 1772041 cctccttatt ccatgtggcg aaagcgggaa aaggaaacgc ccattttatc tgacctgata 1772101 cagcgattcc tccgcgcaac tgaaacgcat ctcctgctat taaagtgccg tttcttgtat 1772161 caagaaatga catgctgccc ggtgtatggc ccggtgttgg aatggcaagc agagaaccaa 1772221 ttgtttcacc gcccgtcagc agttggtgag gctttgtttg tatgtgtttc ggaatacctc 1772281 cttttatagg cgtctgcggc tcatcttgcc gcaaagatgt gtcaccttgg agcaagaatg 1772341 aatcccgttc cgagatcatg acctttgcat gcggaaatgt ttgtgccaat gtatccagtg 1772401 atccgacatg gtccccatgt gcatgagtca gtaaaatatg ctgaagcggt tttccaagct 1772461 gattcacagc ttgaataatc cctttatagc tgcctggcag tgcggcatca ataagggtga 1772521 cttcgttttc ttcctctact aaatagcaat taaccggaaa caatgctgga aaaaaagtca 1772581 gctgccaaac cgtttggtac tgagtaattc tcatcttttt attcctccta acaaaaacta 1772641 atggtgttag ttttattatt aactaacacc attagttttt caagagttta ttattttttt 1772701 atcgctacat aaatgttaac ttgtgctcgc tgtggcactg cggcattttg atcatacatc 1772761 tcaaagtcac ctgtaaacgt gcgcagatgc cgcttatccc aagtccaaat ttccttccac 1772821 gtttcaagca caatctcttc aataggaccg attctggaag tgaaaacggc gtaagcggaa 1772881 gccggcaaat caatattttc atatggtccc ggaagaatgt cgtcgtattc ctgaaacgtt 1772941 ccgactgaaa acgtataaaa cccattcgtc tcttgttcat aattcgaata taaggcaata 1773001 atgctcttgt ctttttcagc ctgtgataaa agagcgctca tatcctgctt ccataattga 1773061 tcccacagtg ccggaatcct cctttcttcc gtcatttcca gtgcgttgct tgtccgttgt 1773121 gatagtccgg caaatcgttt caggtctaag tgtgttatat gtgaaaagcc catacgatct 1773181 cctccttttt ttaagattat agacaaagaa acctgacagc agtgtgtcag gtttcatata 1773241 ttttttgcat gtgatgaatg gtttctttta ctttatccct tatatgaaga ggctgcagaa 1773301 cctcaatatc ctttccgaac tggagcaaaa aaccgatcag ccattgatct tctggaagtg 1773361 aaatcaccgc ctggcagatt tcatcttcct cacaacagtg aaggacatca tatccgaacc 1773421 attcacctat acgctgacgt gctgacggct gaacaagaat aaccaattca gttaaacggt 1773481 ccttttggta ccaactctta tcccatggca aagtgtccag ctgaatgtct tttctgataa 1773541 atgtctgatg taagatggcc agatctttca tccggttcag tttaaaaaag cgaaaatcat 1773601 ttcttaccag gcagtaggca tataaatacc agtgccccgc cttgcaaacc aatgtataag 1773661 gttcagtttc ccgaagtagt gtttccccgc ttgcgcttgt atatgtaaaa gatatcgtta 1773721 acaaccgatc gatggcagcg ctgattttct cgcgcagcgt cttttgatcc tcagtatggc 1773781 cccaagccgt catgtcaata aaccattttt ctgtttggtg cttaaatgct tgagtagatt 1773841 gctcaggtat aaggtgtttg attttttgat aggctgtgct gtgagaaacg ggttcataca 1773901 tagatgaaac gctttgcaaa gcggaagcaa ttgcaaacaa ttcctcctcc ttcagccact 1773961 ctctttcaag ccgatacgtt tccatgatgc caattccgcc cccggaaccc tgtgaggtca 1774021 caatcggaat accagcccta ttgatcgtct caatatcacg gtaaattgtt ctgacagata 1774081 cttcaaacag ctcagcaagc tctgcagcct gcacttgttt tttgctgatc aataacacaa 1774141 ccatcgctaa caaacgttcc agtttcattc tgcgcacctt ttcttcttgt attttccaac 1774201 aaaacaatca taacattttg ataaagcttg ggcatatcta ttatgcggcg gaatacacct 1774261 cgcatatgct atgaaaacag gggtttcccc ttcttttttg tgttcagtat ttatttcagc 1774321 tactatttcc gaccggataa gcatacactt ctcaacggag gggatttcac atcatgcatc 1774381 ttacacttca gagcgtttat cctgccataa tcatcatctt ttttctgtat aaaaaaatta 1774441 aaaggtccat cggataccag ccgctgaagc cccgctggct gttcacccgt atcattcttt 1774501 tctcgctgtt tgcttttgga ctttcaatct tcagcgccat tcaccctttt ttatatggat 1774561 atctcatttt gggcattctt ggcggatggc tccttgtctt tttcgctaag aaaaacatct 1774621 cttttgaaaa acgcagagga aagatctatt ttcggactca tatttgggta gaggtgattc 1774681 tcttaacttt atttctatca agatttctgt atcgagtgac ggagctttat cttacctcac 1774741 ctgatctaaa ccgccttgga tcatacagtc agtcaatcgg aacggaccct ctgacaattg 1774801 gcgtctgttt tctgatagcc gtttattata tcggtttttc ttcttttatc atcaagctca 1774861 gcagaaacga acttgaacag cacgaataca ataaagaaaa agacatcctt gcccgctaac 1774921 agcgagttaa gcaaggatgt ctttttcaat catgctgtgt atgatggatc atttgctgaa 1774981 gaacatctaa aacatgttca tcctccggag agtaataaat cgatgttcct tctctgcgcg 1775041 atttgacaag ccggagattt tttaaaaatc taagctggtg ggacacagtg gattgcagta 1775101 aattcagctt ttctgcaatt ccgtttactg catgctcacc ttgggacaat aaatggagaa 1775161 ttctgattcg ggtaggatct gaaagcgctt tgaatgtttg cgcgactaga aacagcgtct 1775221 cctcgtccag atcagcagcc gattgttccg tttctctaaa ttcagtcata tgtatcacct 1775281 ttctttattc atagttttat cttataacaa atgcgcttga gtgcaaacca gcctgcttgt 1775341 attccatttc aatctcatag tttaaattta tgtttcaaat caggttttta cttggtctga 1775401 tataccctct tatgtcataa taaaaaaggt catactgctc caaacattga gggtgaaaca 1775461 cagtgaagaa aaagagaaaa ggctgtttcg ctgctgcggg ttttatgatg atttttgtct 1775521 ttgtcatcgc ctctttttta ttggtcctgc tttttttcaa ccgggattta atcaaaaaac 1775581 ttccgatcga tacgaaaacg attgttttgg aacgtttaac cgattacaaa cccttggtgg 1775641 aagaagagct tgaaagccaa ggactctcta attatacatc actcatatta ggcatgatgt 1775701 atcaggagtc aaaaggaaaa ggcaatgatc ccatgcagtc ctctgaatct ctggggttaa 1775761 aacgcaatga gataacagac cctcaactca gtgttaaaca aggcatcaag caatttaccc 1775821 tcatgtacaa gaccggtaag gaaaaaggcg tggatttgga taccattatt caaagctaca 1775881 acatgggggc aggttacatt gattttgtag ctgaacatgg aggaacgcat actgaggaat 1775941 tggcaaaaca atactccgag cagcaagtca aaaaaaatcc tgatctgtat acttgcgggg 1776001 gaaatgcgaa aaatttccgc tatccgtatt gctacggtga ttatacgtat gcagaaaaag 1776061 taaaagaaaa aacaaaaact gttgaagaat ctttgcaggt tgcaacactt gaaaccatgg 1776121 aatccaaggc tcatgaataa gagtctatca atttactgac aaaagcccaa aaatgaattt 1776181 gggcttttgc catgtttaca cgtaaaaaaa gccatactga gtatggcttt taataatacg 1776241 gtgaaatcat caaatataca ataacgcctg taaggcttac atacagccat agaggcattg 1776301 tccatctcgc aattttttta tggcgctcca cctgcatgct gaagcctctg atcagcgtaa 1776361 acagcgcaag cggcacaata attgcagaaa ggcagatatg tgtaattaaa ataaagaaat 1776421 aaatcgggcg cataatacct tctccgccat agagcgtgtt ttccgcaatc gagtggtacg 1776481 tcacatagca aatcaaaaat agtaatgttg ttgtgaacgc agccaaaata aagcgtttgt 1776541 gagctttgat atttttctgt ttaatcataa tcagcgcggc caataagaag ataaacgtaa 1776601 agctattgaa tatcgcattc agcattggca aaatgtgaat attcgcatgg ctgaactgat 1776661 ctaatttagg cataaaaaac agcactgcga ttaaaccgtt aatcagaact gtcagcgtaa 1776721 ggacaatccc cgtgtaattt ttcggtttat tttctgtttg gttcatttgg tgacctctcc 1776781 taatttgtac tggctatcca aatcgtatgc aaattcaaag aagatgtcaa cggtttcgat 1776841 tgcttcgtca gaaattagac acacttcaaa ggccggaggc tattagcccc ggcctgttag 1776901 gtttacgcct cttttatcaa atgttcaatg accttatgtt cattttcatt cagcaggttc 1776961 ttttgaattt tcgaatgaat gggtttattc atatgctgat ccaagatatc ggccgtttct 1777021 ttatccccgg caataaccat tcgttcccat cttttcgcgg cagctttttg atcaaggctg 1777081 gcagccagcc gcttatacag tctcgattgg ttctctgtta catgttccct catccggttc 1777141 tcttcaaatg gtggcgcttt gtctacagcg gaatggctat tcttccaaga ctcattgatc 1777201 atatcatact cataacgctc caccgcctca atttttccta aaacagtttc aataattttc 1777261 acttcatgct gctgagttaa aataaacgcc gtacttgggt atgtctggcg caaacccttt 1777321 agctgatcca ggacagctgt ttcttcccag taaaatcttg tatctacagg gacttgaagc 1777381 ttaataggtt cccatatgcc gctgtcggaa acaaaaaaca cgagactgcg gggcatgtct 1777441 tttcccattg cattcaagta ttgattcatt ttagccctga ttccatccag acacttttcc 1777501 tcctctggat cactagctgc caaatactct tttaatcggc tgaatcctga ctttagggca 1777561 atcttccatt ctcccccctg ctgctctgga tctctcatgt ctgtattgag atacagagag 1777621 agaattttat ccggcggttc caattggaca tactgtaatt tgttaatcaa tgaatcaatc 1777681 gccattccga ttcctccttt ttcacaggtt agttttcttt ttcctctctt aaaaacgatc 1777741 aaacctgact ttccgctaat ttctagtaat aatggaattg ttgtttacaa tacgcctctc 1777801 ttctaataca attggtaact gtgtttctaa gctgtttttt gaaaggagtt tgatcttgtt 1777861 tactgttaaa gaaaaaaatc gtcaagagct tgaggaagaa ctaaatgatt tagaatttca 1777921 aatttatcgc atgcaggaga atatgaagga tttatctaaa gatgccaaag tgcttggtat 1777981 tgatcaatcg aaacatgatg agtggatgat tgtttcctcg attgatgatg gccaaacatg 1778041 caaaattatg ctaactgatt gtaaaacggc ataccgagga aaaggctgtt tttcacttgt 1778101 agcgtcttac aaggacgatg ccattcatat aggggatata aaaggccctc cgaatcacgg 1778161 gtttggctcc atttgcatga aatatttaaa agatattgca agagaccata atataccgaa 1778221 agtcaccgga gacatcgcca aacgggattg gaatcatgta gaccggctga ttcactttta 1778281 tgaaaaacat cacttcaaag tatgtatcga tcatgatacc caatccggca gcattaagtg 1778341 ggttgatttg taaaaaagtc tggaagaaag agccaagata tgctgtaatg gtataaaacc 1778401 attgatggag ggttctatgt acgcctcaaa actgaaaaag ggagacgaaa tccggatcgt 1778461 gtctcccgcg accagcatgt ctatattatc aaatgaagca aaaatccaag caaaaacggc 1778521 gttagaacgc ttaggttatc gggtaaccat cgctgaacac gcaaatgaat gtaacgaatt 1778581 tgattcatcc tctatcgagt caagagtcca tgatctgcac gctgcctttt ttgatccagg 1778641 cgtcaaagcg attttaacga cactcggagg gtttaattca aatcagctgc tgcgttatct 1778701 tgattacgag aaaatcaaac gacatccaaa aattctgtgc ggttattccg atataaccgc 1778761 tctttgcaac gctatttatc aaaaaacggg tcttgttacg tattcaggtc cccacttctc 1778821 aacatttgca atgaaaaaag gactcgatta tacagaggag tattttcttt cttgctgcgc 1778881 ttcagacgat ccgtttgaaa ttcacccctc aagtgagtgg agcgatgatc gctggttttt 1778941 ggatcaagaa aacaggcgtt tttatcctaa taacggccct gttgtaatcc aagaaggtta 1779001 tgcggaaggt actttaattg gcggaaactt atgcacgctt aatttgctgc agggaacgga 1779061 gtattttccc gaaacagaac atactatttt attgattgaa gatgattata tgtcagacat 1779121 ccatatgttt gaccgcgatc tgcaatcact catccacctc cccgcttttt cacatgtaaa 1779181 ggcgattttg atcggcagat ttcagaaagc atcaaacgta tcaatagatc ttgtaaaagc 1779241 catgatcgaa acaaaaaaag aattatccgg catcccgatc atcgcaaata taaatgccgg 1779301 acatacctcg ccaattgcca cgttccctat aggaggaaca tgcaggattg aagctatttc 1779361 gggtacatca cgaatatgga ttgataaaca ttaatcagct tgtaaatttt tttacaagct 1779421 tttttagcgc aatcggctat gcatgccgca cgagacatga caaatgtcat ataggaggca 1779481 tgatgtgtgc tactacaaaa gacttctctc attagcgtat actgaaccga gacacacaat 1779541 gagaggatac ttactatgac tgaacaaacc attgcacata aacaaaaaca gctgacaaag 1779601 caagtcgctg catttgctca gcctgaaaca aaaaacagcc tgattcagct tttaaacacg 1779661 tttatcccat tcttcggcct atggtttctt gcttatctca gcctcgatgt ctcctatctt 1779721 cttacgttag cattaacggt gattgccgca ggttttctga caagaatttt tatcatcttc 1779781 catgactgct gccatcaatc ttttttcaaa caaaaacgct ataaccacat tctcggtttt 1779841 ctgacaggtg tcctgacttt attcccgtat cttcaatggc agcacagcca ttcgattcat 1779901 catgcaacta gcagcaatct ggataaacgc ggaacaggag acatctggat gttaacagta 1779961 aacgaatata aagctgcatc cagacgaaca aagcttgcat acagacttta tagaaacccg 1780021 tttatcatgt ttattctcgg accgatttat gtttttctga tcacgaaccg ttttaacaaa 1780081 aaaggcgcaa gacgcaagga acgtgtaaac acatacctta cgaatctggc aattgtcgcg 1780141 ttggctgccg cttgctgtct gatctttggc tggcaatcgt ttttactggt gcaaggcccg 1780201 atatttctga tttcaggttc aatcggtgtt tggctgtttt atgtgcagca tacctttgaa 1780261 gattcttatt ttgaagcgga tgaaaactgg agctacgttc aggctgctgt tgaaggcagc 1780321 tcattttata aactcccgaa actgcttcaa tggctaacag gcaatattgg ttaccaccac 1780381 gttcatcatt tgagtccaaa ggtgcctaac tataagcttg aagttgctca tgaacatcac 1780441 gaaccattaa aaaacgtacc gacaatcacc ttaaaaacaa gcctgcaatc acttgcgttc 1780501 cgtctatggg atgaagataa caaacagttt gtgtcatttc gggctataaa acatatacct 1780561 gtaagccttc cgcctgattc accagaaaaa cagaagctgc ggaagaatgc ctgatgataa 1780621 aggaggtctt ctaatatact agaaggcttc ctttttattg ttggagggtg cattctggct 1780681 ttcacaatga taaagttaca agtaagatga aaagctgaaa atgaggtaag atcatgatta 1780741 aaaatcattt tacatttcaa aaactaaacg ggattacgcc ctatatatgg acgatatttt 1780801 tcatcctccc cttctacttt atatggaaat catcatctac atttgttatt attgtcggca 1780861 tcattttgac gcttttattt ttttcggtat atcgatttgc ttttgtctca aaaggctgga 1780921 ccatttattt gtggggattt ttattaattg gcatttcaac cgcctccatt actctgttca 1780981 gttatattta ttttgctttc tttattgctt attttattgg aaacattaag gaacgcgtcc 1781041 cttttcatat tttatattat gtccatttaa taagcgcggc cgtcgcagcc aatttcagtc 1781101 tcgtattaaa aaaggaattc tttctgacac aaattccttt tgtcgttatt accctcatca 1781161 gcgcaatttt attgcccttc agtataaaaa gccgcaagga gcgcgaacga cttgaagaaa 1781221 agctcgagga tgcaaatgaa cggattgcag aactggtaaa attagaagaa cgtcagcgaa 1781281 ttgcccgcga tctccatgat acgcttgggc aaaagctttc tcttattggt ttaaaaagcg 1781341 acttagcaag aaaattgata tacaaagatc ccgaacaagc agctcgtgaa ctgaaaagtg 1781401 ttcagcaaac agcgcgaact tctttaaatg aagtaagaaa aatcgtttcc tctatgaagg 1781461 gcatccggct caaggatgaa ttgatcaaca tcaaacaaat tctcgaagca gctgacatta 1781521 tgtttatcta tgaagaagag aaatggcccg agaatatctc attgctgaat gaaaacattt 1781581 tgagcatgtg cttaaaggaa gctgtcacaa atgtcgtcaa acacagccag gctaaaactt 1781641 gccgagttga cattcagcag ctctggaagg aagttgtgat tacagtgtct gacgatggaa 1781701 cattcaaagg agaagaaaat tccttttcaa aaggacatgg cttactcggg atgagagaac 1781761 ggcttgagtt tgcaaacgga agccttcaca tcgataccga aaacgggacc aagcttacca 1781821 tggcaattcc taataattca aaataaacat aaaggatggc ttatatgatt agtatattta 1781881 ttgcagaaga tcagcaaatg ctgctgggcg ctttaggatc acttctaaac ctcgaagacg 1781941 atatggaagt cgtaggcaaa ggtacaaccg gccaagatgc tgttgatttt gtcaaaaaac 1782001 gccagcctga tgtatgtatt atggacattg aaatgcccgg aaaaacaggg cttgaagctg 1782061 ctgaggagct aaaagataca ggctgcaaaa ttatcatctt aaccaccttc gccagacccg 1782121 gttactttca gagagctatt aaagctggcg ttaaaggcta tttgttaaaa gacagtccga 1782181 gtgaagagct ggccaacgcc atccgtagcg tcatgaacgg aaaacgcatc tatgcacctg 1782241 aactgatgga ggacttatac agcgaagcta accctcttac agatagagaa aaagaagtgc 1782301 tcgaacttgt ggctgacggt aaaaacacaa aagaaatcgc tcaggaactc agcatcaaaa 1782361 gcgggacggt gcggaattat atctcaatga ttctagaaaa gcttgaagtg aaaaatcgaa 1782421 ttgaagccat tacccggtca aaagaaaaag gctggtttaa ataaaaaagg atcttggcat 1782481 ctgccaggat cctttttgtt aacctgaaat tcccgtttga gaacctcgtc gcaaccagaa 1782541 ttaaattgat ccatatcctc gctcctacgc ccgctgaacg attgtttggt taacagccca 1782601 ataaaagact ggattgaatg atatccctgt taaaatggtc ggccattgca catcagcaga 1782661 atttctgata ttgattatat tgtattttca gtatgacaaa gttgtgccac ttcgctcccg 1782721 aagctgccat gcccaactgc aagagcctaa tatcacaata aaaaaccgtc tgaaatcaat 1782781 ccgattccgt aaatggtatc tgctacatcc aactgcttat tatctgccaa aaacaccagc 1782841 tcgtttcgct gatcaaagat agtaacaacc agctataaat gtcatgatgc cgaatgtctc 1782901 tgtaatgtgg aatcaatctt ttaacccgag agcccctgaa tcgcacataa agaaaaacgg 1782961 gaccactttc ttttatcagc atatgatata aacagctcta agcagaacaa aaaaagacac 1783021 aagccaaaag cttatgtctt ttatcacaat ctatattatt agtttaagac tttaacactt 1783081 acagttttga cgccccaatt agaagcatca cttttacttg gtacaaatac gtcgatttta 1783141 tttcctttaa tagcgccgcc agtgtctgct gctgttgctt ccccgtagcc ttcaacatag 1783201 actttagaac ctagcggaat tacattagga tcaaccgcaa taactttcgc gttcgggttc 1783261 ttatttaagt caatgcctgt agctgtaacg ccggaaatgc cgccgtcgtt agcagtgtaa 1783321 gcagtagcag taactgttag ttcttttgaa gcttcttgat tatttgtatt tgattgaaca 1783381 gccttctcct ctgtgttaac agaagtttct gcctcagcct ttgtttcttg tttaggttgc 1783441 tgttgtacag cttcttgttt aggttgctct ttttgcacag cctcttgttt tggcgcagct 1783501 tgaggtgcgt ttgtttgcgc attctcagta gctgtgtttg ctgctgttgc ctgacctttt 1783561 actgaaagag ttgatccagc atagatcatg tcagagctta agttattcca aactttcagg 1783621 ttgttgactg tcgtgccgaa tttttgagca atcttagaaa gcgtatctcc cgctttaatt 1783681 gtatattgcc cagtcgtggt tgtttcttct gaagaaatgg tcagtttttc tcctgcaatg 1783741 attttatcag aagttaactt gttccattct tttaagtcct ttaggttcac tccatttttc 1783801 tgagagattc cccagagcgt atcacccttt tgcaccgtaa tttcttttgc agaagcgtga 1783861 gctccgaatg cagttgttga aagtgcagca actgccacaa aggacataat cgtcttcttc 1783921 ataagtaaat cctcccttgt tagcttttta ttggcggcta acaggtgata tcgtaacaca 1783981 cgtaaatgtc aaatcaataa caaaaagata tgatttagat tacagttcct ttacatgaag 1784041 gatttctctc tgatggaaag acttgctgaa cccttgatat aataggcttc gcaggtcttt 1784101 ttattttgag gcgaaacaga gaaaataaaa tgtgtttttt atagaaaaaa agattgtttt 1784161 tctgtttttt tagtctgtca tccttgcata agcctgtatt tcttgtaaaa aaagccggcc 1784221 gtattttgct cttttttgtt ctccgactcc ttttatagac aaaagttcat catcatttac 1784281 gggctgtttt cctgacattt cttttaacgt ttggtcagag aaaacaacaa atggcggaac 1784341 accctgctca gccgcaattt ctttccgaac catgcgcaat cgttcaaata gctcgtcatt 1784401 ttcagtaatc gctgccgctt ttaacgcttc ttttctcgct actgataatt ctcctttcag 1784461 cacattcctt cctttactgc tgacaaaaag agtcggaaac gttccgtctg acatcctgat 1784521 gaagtcgtca gaaataagaa attcgataaa atcactgatt tcgccaacgg attggtgttt 1784581 taatatcccg tatgttgaaa ggtcggaaaa gccgttttca agaacttttt tatttttgga 1784641 gccggcaagc acctgggcaa ccatcgtctt gccaaaccgt tctttcatgc gaatgataca 1784701 agataagacc atttgcgcct cccgcgtcac gtcatgggcc gctcttgtat cggtacagtt 1784761 tccgcactgt ccgcacgcat caggctcctt ttctccgaaa tacataagga taaaacgctg 1784821 cagacaatct tccgtatgac agtagtcgac catttgtctc agctttttta aatcctgctt 1784881 ttgtttctct tcatgttctg attgctcaat taagaagcgc tgcaccataa tatcctgcgg 1784941 tgaaaacagg agaacacatt cactggcaag accgtcccgt ccagctcgtc ctgcctcttg 1785001 ataatagctt tccatatctt tcgggatttg tgcatgcaga acaaatctga tatttgattt 1785061 atcaataccc attccaaaag cagaggttgc caccatcact tgaagctcat cattaagaaa 1785121 tctttcctgc tgctcttttc tcacatcatc agccaaacct ccatgatacc ggcctgccct 1785181 gacctgattt cgtttcaatc tctcatatat ccgatcagct tcttttctgg tcgctgtata 1785241 gacaattcct gcttcatgcc tgttgttttg cacatattcg tctataaacc gatctttatt 1785301 ttctcctttt actactttaa aggttaaatt ctctcgggaa aatccggtat ataccgtgtt 1785361 ttctttttga atatgcagct gtttgcaaat atcatcatga acctcgggtg tggctgttgc 1785421 tgttaacgcc atgatgacag gcttgtcgtg taattcacgg aacaagattt caatattcct 1785481 gtagcttggc ctgaaatcat ggccccattg agaaatacaa tgcgcctcgt ctattgcgac 1785541 caaaggaaca tctatgccct gcaaaatccg gataaactct atggacgtta gtcgctctgg 1785601 tgtaatgtaa aaaagcttat aagccccttc tttgagtccg ttcagcctct catatatttc 1785661 ctgattggat tgtgtgctgt taatgtaggc ggcgttaatc cccgcttctt ctaacgcatc 1785721 aacttgatcc ttcatcaagg aaatcaacgg tgaaatgacg atcgtcgtcc cttcaaacat 1785781 taatgccgga atctgatagc aaatcgattt gccgcctccc gtcggcataa tgcaggccgt 1785841 attttgcctc gcttccgtca ccaagcggat cgcttcatct tggccgctcc gaaacttctc 1785901 ataaccaaaa taatgagcca gaagggattg ggctctatgt aacataacgt gtaaacctcg 1785961 cttttccttg aatttctccc atcatatcat aaaaaagcgg ccttcatttc tttcacacaa 1786021 aaatggaata ttcactatac caaacctttt tagataaaat aaaaagccat ttccgaaaag 1786081 gaaatggctt tcgctacgtc ttgccgtatg caagtaagaa agttttaaac caccactcct 1786141 caaagtgggt gtttgcagaa acgttcctgt cgtcctctgc aatggaggca tgacattccg 1786201 gcttcgatat aaaactccct attacagctt aaaggttaaa acttaattaa caatacgcac 1786261 aaagtagctt ctttaatata gtacaccatc aggcgctttt aatcaagagg tcagaacaat 1786321 tgtttagaaa aactttttcc agtgaataaa actgtttttt ctccaaaata cctgacaatt 1786381 cgacaaacaa aaaatatatt acaataaaaa aaatagcctt tattgctaaa agcgaatgat 1786441 tattttcttc tatattaatg tgtatataca aaaagactcc tatttgtaac gataggagtc 1786501 ttggctttat tagaattttg cagcaagatc ttttgcttct tgtaaacctt tttcaacgat 1786561 ttcttgcgct tgatcaggtg ctgcgttatg tccttcgatg acaactgtgt gcaagtcttg 1786621 aacaccccag aaaccaagaa ctgttttcat gaagtttaat gacatttcaa gtgcagccat 1786681 tggtccttct gagtagacac cgccgcgagc gttaagaagc gcaacttttt tgccgcccat 1786741 taaaccgact ggtccttctt gtgtgtattt gaatgtaacg cctgcgcgag acagataatc 1786801 aacataagta tgaagcactg ctggcactgt gaagttccaa agcgggaatg cgaaaacaac 1786861 tttgtcagct tttacaaact ggttcagata tttgtcagca attgctgctt gttttttctc 1786921 atcttctgtc atttccattc cttgacctgc tttaaatgtt ccgttaatca tatctctgcc 1786981 aaggtaagga aggttttcct tatgaagatc taattcaacc acttcatcat tagggttgtt 1787041 ttctttataa gcagctaaga aagcttcgta aagtttagtt gaaacgcctt cttcagctgt 1787101 acggtcgctt gattttacaa ataaaactgt agacatttgt attcctcccg gtaaactttt 1787161 tatatttact tacaaatagt atgttacttt cttttttacg taaagtcaat cactttattt 1787221 tgaatatgag attttttttc aaaaaaaagc aagtacatct aatatcggtg tacttgcttg 1787281 gcatttttac ttcgaatctt gttcacgatc caagatttca tacgtctgcg agcttttttg 1787341 atcaattgtt tctttgttgg ataagtcttt tacctgttca tgaaactctc tttcataaga 1787401 aggagcatct gtctccagat catcctccac atcagcttgg gcctcaactg tcattcttgc 1787461 ataaggaaca gcttcaagtc tttcgtaagg aatctcttgg ccggtttttt cacacacgcc 1787521 ataagttccg tctttcatct tttgtaatgc acggttgacc tcctctaaca gctcccggtc 1787581 aatctctttc actgtttggt ctgtcatccg gtctgtgacg agcgtcccgt ggtctgccat 1787641 atggttgtca accccattgg aaagctcccc cacttcttcc gtcattgatt ctgtttcctt 1787701 tttctcgcca gacaattctt tttgcatatc gagcaattta tgatagagat gctgtgtttg 1787761 ttcttttgtc agtgccatgt atatcctctc ctttctatcc tgtttcccgt tttgccttct 1787821 gtcaaacatg gaaacatcga tggaaagatg agctactgcc tttttgaacg gatcgtgacc 1787881 gctggcgtcg atggtgcttc gggttttcgt tggcactttt tgtccttctc ttctggcggt 1787941 atataatagg ttgcgcctat atttaatctg ccgctcagtt catcaatggt cagctcgccg 1788001 aattcaagat gatagtcaac tttttcgaca ttcagcgttt caatatgtat ataggtttct 1788061 tcagactctt gtttgctgct ttgtttttgt ttctcaatca ctgagagtct ttcttcacat 1788121 tcacgcagtt tgtcaagttc tggtttcaag caatgcctga tcagcgaccg gaacattttt 1788181 ttcatgacat cacgaccctt tgcatactcc tctttcgtct acatatataa tgaggtatat 1788241 cccatagaaa ggagaggttt tcatgcttcc gactaacatc aatatttctc atctcaagac 1788301 taactcgata ggcaccggct catcccttac ctttggttct gcggagttaa ggaacaggtg 1788361 ctctgctatc aaaagaaata acggttttgg ggaacaaaat gcagatggta ttgttatggt 1788421 cattccgatt gaatcaattg atgaccgtga tgtgtcagat gcactcagta tgaaaatcaa 1788481 tcatcaataa caatggtttt cgcttgacct tcgtcttttt gaatagtgat gtataggatt 1788541 ccgtctttaa aaatggcatt catctttcca tgaagatgat cggaaagcgg aattttcttt 1788601 tcaaaacttc cgtatttccc ttctttttgg cgaaagtcct gttcattaaa ataggaaaag 1788661 cgctgcccct tcaccactaa ataatctccg tacgataata tgtgaacgtc ttgtttacgg 1788721 tagcctggaa gataaattaa aaactgcact tccgcaacgg tatctacaat atccatgctc 1788781 ggaaatgaag catctccttt ccctcgctga tcttgctgcg caaacggaaa cggagattgg 1788841 ccatttgtca taaaaggggt tttttggtct tcatcaaata cctgtttcca aaagtcaccg 1788901 ccgtacatct gctgtgcgaa ttccatccac tgcttcatct tttcgaaatc catttgaagc 1788961 cccctgtctt aacatacttt ataaccgcca gcatacaact atagaaagga ggtttgcctg 1789021 tggttcaacc aactccgtat atcaatatta atattttcat gctgaaaatt aattcctttg 1789081 aaaatgcttc agcggttaac gtaggacaaa atttattggc agaatggcaa aattcagata 1789141 aaaaaaatca aggctacgga cagaattttg gagatgcgag cggatttatg ggcacgagaa 1789201 gccatgtgga tgacagagac caaattgatt ctccggcctc ttttgaaagt gaagcggtta 1789261 actcctcaat caaaaggaag tgatgagatg ttcttttcac cctccgtcgt aaatgtcggc 1789321 ggatttaaaa tcaatacgat ggatcgaggt tcctctttaa cactcggtcc gtatcagcag 1789381 gtcgattact ttttatcagc taaaataaat caagggtttg gagaagaaaa tggcgacttt 1789441 actcctcttg tcgtgccgat ttcaaatgta ttagatgcag atcttgttga ttcgaactca 1789501 gcgaaaaaca gtgtggtgta ataagaacag ggcgcacatg ccctgttctt gtttttatat 1789561 ataaaaaaag cctaaccatt ttttgaacgg ctggctcatc aaatattcag ctgcacaaat 1789621 gctttgtcag caccgcctga acctcgctta aatcggtgtc tttcgcaaat tctaattcga 1789681 aagttttgct tcttgtcatc aataaaagcc cagtgtccgg atcaaacatt cccgcttctt 1789741 ggatggcaaa gctttcaatt gttttatatg gaagaaatac acgaaccttc tttttagaaa 1789801 acattttatt gtcaaagaaa atgatccgct tatttgtaaa gcaaatttgg tccactcgga 1789861 gcttataaat cgattcaatt ctttcccctt caacgagcaa agcctcaagc ttctttgcgt 1789921 ccgttgatct gctaacagaa aaaataccca atgaagaacc cctctttctg catttatcta 1789981 tttgttttat cattcactac ataaaaataa gtcctttatc cctatataag aatacgacat 1790041 agaagacatt taaaccatta cgaacagatt acatttttca aatttttgat ttgttttttg 1790101 gcttttaagc tgttgtcatc aagtaatacg cacatataga gaaaaaagtt tcaatattca 1790161 gcaatgtttt tataaaaaag tggtttttaa tgattttttt aattttgttt tatatttcct 1790221 gttttaacca caaaaaaacc gcagctgagc tgcggtttta tgtatcgact gcttttaaca 1790281 aaatctgttt gatgcttcaa ggaagcatta catctcttcg aagtattctt tataatagcc 1790341 gccgacttta ttcgtattgt cgaccacaaa gagaaactcc tctgtttcat tttttacttc 1790401 atattctttt cccggcgtta aaacgcggtt tacgatatat ttttttgcgt ttgtctgcac 1790461 acactttact tttttaatgg tttctttttc aagccaattt ttatgaatca tgatgaaatc 1790521 tccttttctt atctataagc ttattgtagc ttttttcttt tgtaaattgc aatatcggtt 1790581 attcattgat tttgccttga tttctattat agaatgtttg tatacgctta cgtttgaagc 1790641 aactatcaca gcttatttct gctattcaat ccaggaatca atgtgctatc accaagaatc 1790701 tcagaacaga ccataaaaaa tgactggagg tttgttacgg atgagttctt taacgatgca 1790761 agtgacgaaa aggctggaga catttttaca gggaacaaag aagctttata ttgacggaaa 1790821 gtttgttccg agtgcctcag gggcaacctt tgacactcca aacccggcga ccggcgaaac 1790881 cttgatgacg ctgtatgaag cccaggctgc ggatgtggac aaagctgtta aagctgcccg 1790941 gaaagccttt gaccaaggtg aatggagaac aatgtctcca gcttcgagaa gcagactgat 1791001 gtataagctg gcagacttaa tggaagagca taaaactgag cttgctcagc ttgaaacact 1791061 tgataatggg aaaccgatca atgaaacgac taatggagat attccgctgg ctattgagca 1791121 tatgcgctat tacgccggct ggtgtacaaa aataacagga cagacgattc cggtttccgg 1791181 cgcttatttt aattatacgc gtcatgagcc tgtcggtgtc gtcggccaga tcattccatg 1791241 gaatttcccg ctcctgatgg cgatgtggaa aatgggcgcg gcacttgcaa caggctgtac 1791301 aatcgtcctc aaaccggctg aacaaacacc gctttcagct ctttatttgg cagaattaat 1791361 tgaccaagcc ggtttccctg ccggtgtaat caacatcatc ccaggattcg gtgaagatgc 1791421 gggagaagcg ctgacgaacc acgaagcggt tgataaaatt gcctttaccg gttccactga 1791481 aatcggaaag aaaatcatgt ccaccgcagc gaaaagcatt aagcgtgtga cattggagct 1791541 gggcggaaaa tcgcctaata ttcttctgcc ggatgcgaat ttaaaaaaag ccatcccggg 1791601 cgctttaaac ggtgtgatgt ttaaccaggg ccaagtctgc tgtgcgggct cacgtgtctt 1791661 cattcataaa gaccaatatg atgaagttgt tgatgaaatg gcatcctatg ctgagtcact 1791721 ccgccaagga gcgggacttc ataaagatac tcaaatcggg cctctcgtaa gcaaggaaca 1791781 gcatgagcgc gttctttcct atattcaaaa aggaaaagat gaaggagcaa aagcagtgac 1791841 cggcggaagc tgtccttttg aagcaggata ttttgtcgca ccgactgtgt ttgcgaatgt 1791901 tgaagacgaa atgaccatcg caaaagaaga aattttcgga cccgtgctga ctgcaattcc 1791961 gtacgaaaca gtcgatgaag ttattgaacg ggcaaaccat tcagaatatg ggcttgcagc 1792021 cggactatgg acagagaacg tcaagcaggc tcactatatc gcggaccgac ttcaagccgg 1792081 aaccgtttgg gtcaactgct ataatgtgtt tgacgcggcg tctccatttg gcggttataa 1792141 acagtcagga ctcggacgag aaatgggatc atatgccttg gataattaca cagaagtcaa 1792201 aagtgtatgg gtaaaccttg aagactaaca tgtatgttta aaaaactgct gcctgccagc 1792261 agtttttttc tttctgtaat ggcagtaaaa gacgctgaat atatatgctt ctgaaggagt 1792321 tgagcgtgat gggcacactt caggagaaag tgaggcgttt tcaaaagaaa accattaccg 1792381 agttaagaga caggcaaaat gctgatggtt catggacatt ttgctttgaa ggaccaatca 1792441 tgacaaattc cttttttatt ttgctcctta cctcactaga tgaaggcgaa aatgaaaaag 1792501 aactgatatc atcccttgca gccggcattc atgcaaaaca gcagccagac ggcacattta 1792561 tcaactatcc cgatgaaacg cgcggaaatc taacggctac cgtccaagga tatgtcggga 1792621 tgctggcttc aggatgtttt cacagaactg agccgcacat gaagaaagct gaacaattta 1792681 tcatctcaca tggcggtttg agacatgttc attttatgac aaaatggatg cttgccgcga 1792741 acgggcttta tccttggcct gctttgtatt taccattatc actcatggcg ctccccccaa 1792801 cattgccgat tcatttctat cagttcagct catatgcccg tattcatttt gctcctatgg 1792861 ctgtaacact caatcagcga tttgtcctta ttaaccgcaa tatttcatct cttcaccatc 1792921 tcgatccgca catgacaaaa aatcctttca cttggcttcg gtctgatgct ttcgaagaaa 1792981 gagatctcac gtctattttg ttacattgga aacgcgtttt tcatgcacca tttgcttttc 1793041 agcagctggg cctacagaca gctaaaacgt atatgctgga ccggattgaa aaagatggaa 1793101 cattatacag ctatgcgagc gcaaccatat atatggttta cagccttctg tcacttggtg 1793161 tgtcacgcta ttctcctatt atcaggaggg cgattaccgg cattaaatca ctggtgacta 1793221 aatgcaacgg gattccttat ctggaaaact ctacttcaac tgtttgggat acagctttaa 1793281 taagctatgc ccttcaaaaa aatggtgtga ccgaaacgga tggctctgtt acaaaagcag 1793341 ccgacttttt gctagaacgc cagcatacca aaatagcaga ttggtctgtc aaaaatccaa 1793401 attcagttcc tggcggctgg gggttttcaa acattaatac aaataaccct gactgtgacg 1793461 acactacagc cgttttaaag gcgattcccc gcaatcattc tcctgcagca tgggagcggg 1793521 gggtatcttg gcttttatcg atgcaaaaca atgacggcgg attttctgct ttcgaaaaaa 1793581 atgtgaacca tccactgatc cgccttctgc cgcttgaatc cgccgaggac gctgcagttg 1793641 acccttcaac cgccgacctc accggacgtg tactgcactt tttaggcgag aaagttggct 1793701 tcacagaaaa acatcaacat attcaacgcg cagtgaagtg gcttttcgaa catcaggaac 1793761 aaaatgggtc ttggtacggc agatggggtg tttgctacat ttacggcact tgggctgctc 1793821 ttactggtat gcatgcatgc ggggttgacc gaaagcatcc cggtatacaa aaggctctgc 1793881 gttggctcaa atccatacaa aatgatgacg gaagctgggg agaatcctgc aaaagcgccg 1793941 aaatcaaaac atatgtaccg cttcatagag gaaccattgt acaaacggcc tgggctttag 1794001 acgctttgct cacatatgaa aattccgaac atccgtctgt tgtgaaaggc atgcaatacc 1794061 ttaccgacag cagttcgcat agcgccgata gcctcgcgta tccagcaggg atcggattgc 1794121 cgaagcaatt ttatattcgc tatcacagtt atccatatgt attctctttg ctggctgtcg 1794181 ggaagtattt agattctatt gaaaaggaga cagcaaatga aacgtgaatc ttatcaagcg 1794241 gagatgttca attggtgtga agccctgaaa gatcagattc aaaagcgagg tcagcttgac 1794301 cagtttgaag atcaaatcga caagatgatt gaggctctgg aagatgacca aacaacagaa 1794361 gaagattggt ataaacaggc cgctgccctt tatcgggata ttacagaatc agatgataca 1794421 agtgaaagac gcgcttatgt ccctataggg aaacacgtgc tgccaaagct tccttacaaa 1794481 tactccgcct tagaacctta tatatcacgc gatattatga tccttcatca tacaaaacat 1794541 catcaaagct atgtcgatgg cctgaacaaa gcagaatcag agcttaaaaa agcgagagcg 1794601 acaaagaatt atgacttaat cactcattgg gaaagagagc ttgcgttcca tggagcaggc 1794661 cattatttgc atagtatttt ttggttttct atgcatccaa acggaaaacg gcgtcctaca 1794721 ggggcattgt tccaaatgat agacctttca tttggaagct attccgcttt taaagaacat 1794781 tttacccagg cctctaaaaa agtggaaggc gtcggctggg ccattctggt ctgggcacct 1794841 cgatcaggac ggctggagat tttaacggca gaaaaacacc agctctttag ccaatgggat 1794901 gtgatccccc ttttaccgct tgacgtatgg gagcatgcct actatttgca atacaaaaat 1794961 gaccgggcca gctatgtcga tcactggtgg aatgtcgtgg attggcgcga ggctgaaaaa 1795021 cgttttgagc aggcaaaaga agtcgtttgg aagctctatt aaaaaaagcc ccctttcctc 1795081 gggggcttcg tgtgttaaaa aatacctatc acatgcaaaa acacgatgat gatggcaaca 1795141 ggagatagat atcgaatgag cagcagccaa accgcaaacc actttcgttt gagattggaa 1795201 ccgcttttca gctcgtcaaa caaatcctgt ttcggtattt ttagcggaac aaaaatcgaa 1795261 atcagtaacg cacctaacgg cattaaaata ttgctcacaa gatagtcagc cgcatcaaaa 1795321 atagacagat gaaatatagt gacgtcactt aagacaccgt atgataatgc agacggcaca 1795381 ccgacaataa aaatagcaat accgcctaac caagcgaatc gttttctctt attgatatcg 1795441 cctttcgaca gtactgcgac caaaatttcc agcattgaaa aagcagatgt caatgcagca 1795501 aataaaaata gaagtaaaaa tgctaataaa aagataattc cgaacggcat ttgattaaac 1795561 acagtcggca gaacgttaaa taacagaacc gggccttggt ctggcttgag gccgaatgaa 1795621 aatacagctg gaaaaatcgc aattccggcc attacagcaa caagcatgtt cataacagtt 1795681 acagatacag cggactgtac cagattttcc tgtttctcta aataagcgct atacgttacc 1795741 atgacagata caccgacact taataagaaa aaggattgtc ccattgcata taaaatggta 1795801 ttggcatcaa ttgcagttaa atcaggcatg aggaaaaatt tgattccttc catcgcgcca 1795861 tcaagtgtaa ccgaacgcac cattaaaatg atgaataata gaaaaagcgc cggcattaat 1795921 acttggcttg ctttttcaat tccgctgctt accccttttg caacaactaa aattgttacc 1795981 accataaaga gcagctggcc tcctacagcc aaataaggat ttgaaatggt acttgcaaat 1796041 atcgtatcaa aaccagatgt ttgcgataaa ccgccagtga agccttttat aatataaatt 1796101 aaaatccatc cgcctacgac actgtagaaa gatagaagaa taaagcacgt caccatgcct 1796161 aaataaccga tccaatgcca cttcgttcct ggagcaagtg ttttatagga ctgaacggca 1796221 tctttctgtg ttcttctgcc tatgatgaat tcacctaaca ataaaggcag tccgattaaa 1796281 accgtaaata aaataaaaat aagtaaaaat gcgcctcctc cgctggttcc ggcaacatat 1796341 gggaatttcc atatcgcacc aagcccgata gctgatcctg ccgcggctaa aataaagccg 1796401 agcttcgaag accattgatt tgcttccttc accgtatcac tcctatttga tctaaccatt 1796461 ataaaggttc attgtaagaa tatcttccta tatagtcaag aacattttaa ttagtttaca 1796521 tcatatatct atagacatct gccaaaaact aatattgaat tattcagaaa attatttata 1796581 ataagagaat gttatgaaat ttgtaagaat ttctgctgaa gttcttgata agtgtgttag 1796641 gagtgttttt atggacatca ttagaaaaat aagccatttt gcaggacaaa cctttggcat 1796701 atgggtcatt gtttttgcag tgctgggatt ttctttccca tctttattta cgtggatcag 1796761 ttcttatatt acgatttttc tcggcattat catgtttggg atgggcctta cactgcaagc 1796821 cgatgatttc aaagagctgg tcagaaagcc ttggcaagtt attattggag taatagctca 1796881 gtatacgatc atgccgctcg ttgctttcgg cctcgcattt gggcttcatc ttccagctga 1796941 aatcgcagtt ggtgttattc ttgtcggctg ctgtcccggg ggaactgcat ctaatgttat 1797001 gacattctta gcaaaaggaa atactgccct ttctgttgcg gttacgacaa tttctacctt 1797061 attggcacct gttgtaacac cgttgttgat tatgctgttt gccaaagaat ggcttcctgt 1797121 ctcgccgggg tctttgttta tctcaatctt acaggcggtt ttatttccga tcattgcagg 1797181 tctgattgtc aaaatgtttt tcagaaaaca agtggcaaaa gccgtacatg cccttccgct 1797241 tgtttctgtc attggcatcg ttgcgattgt ctcagctgtc gtcagcggca atcgggaaaa 1797301 tctgcttcaa tcggggttgc tcattttttc agttgttatc ctgcataacg gtatcggtta 1797361 tttactgggg tttctttgtg caaagctttt aaaaatggat tacccgtctc aaaaagcgat 1797421 tgcaatcgaa gtcggcatgc aaaactccgg gcttggggct gcacttgcca cggctcattt 1797481 ctcaccgcta tctgccgtac caagcgcaat attcagtgtg tggcataacc tttcaggttc 1797541 tatgcttgca acatattggt caaaaaaagt gaaaaagaag caagctggat ccaaaagcag 1797601 caatctatca ctttaaatat gcatcaaaaa gggtacatca ctttatcgtg atgtaccctt 1797661 ttttattatc cttctaataa aagctgttca ggatcttcca gtaaattttt gattgtcacg 1797721 aggaaaccaa ccgcttcttt accgtctaca attcggtgat cataagataa agcgatatac 1797781 atcatcggac ggttttcgaa acgctcttca tcaatggcta cagggcgcag ctgaatctta 1797841 tgcatgccca gtataccgac ttgcgggctg tttaaaattg gagttgacat caatgaaccg 1797901 aaagtccctc cgtttgtaat cgtgaaggag cctccctgaa gctcgctaag ggttaattta 1797961 ttgtttcttg cttttttcgc aagctcgccg atctcttttt cgattcctgc aaatgtcagg 1798021 cgatccgcat cccgtacaac cggaacgaca agaccttcat cagcagcaac agcgattccg 1798081 atatcgtaga attttttaac gatcaactca tcgccttgaa tttctgcatt caacagcgga 1798141 tattttttca atgcagccac gaccgctttc gtgaagaaag acataaagcc gagcttcact 1798201 tcattttgct caaaaaattg atctttgcgg cgttttctga gattcatgac agccgtcatg 1798261 tccacttcat taaatgtagt cagcatcgct gatgtttgct gtacctctac aaggcgtttt 1798321 gcaatcgttt gtctgcggcg tgacattttt tgcacttcaa caggtttgtc aaagctttgc 1798381 tgtgcttttt gagcctgagg ctgctgcttt tgctgaggag ccggttttga tgccggtttt 1798441 tcgtacgctt cgacatcctg cttgcgcact cttccaagcg gatctccagt tggaacttga 1798501 gacaggtcaa ttcctttttc tctcgcaagc ttacgggccg acggagaagc gatcgttctt 1798561 gattttgctt cagattgtgc ttcctcgctc acctcttgtg cagctggttc agcctgtttc 1798621 tcttctttta cgctttcctt gctttctgtt ttctctgtag gagcaggggc agaactttca 1798681 cccgcgcctt ctgaaatcgt accgataatt tctccgacct ggacggtatc acccgaatct 1798741 ttcaatacct cttgaagtac acccgattct tctgctgtca attcaacatt cactttatcc 1798801 gtttctagtt caagcagata ttcaccctgt tctacatagt caccaggctg ctttaaccat 1798861 tgggctattg ttccttctga gattgattct gctaattcag gtaccttaat ttccgccatt 1798921 ttttcatttc ccccttagtt tttgcgagtc aagctatcag atacaatacg ttcctgttct 1798981 tttttatgaa ctgtcggatc tccctctgca gggctggatc gtcttcttcg tccaatatat 1799041 tgaacgctta ctccctctgg tgcaatctct gtcaaatacg ggctgatata accccaagcc 1799101 cccatgttct gcggctcttc ctgcacccaa acgatttctt tcaggttcgg aagttttgca 1799161 aataattctt tgactccttt tgccgggaat ggatacagct gttcgattct cgcaatgtga 1799221 agccactctt taccgtcttc taacttatta aaatgatcgc taatgtctat agacacttta 1799281 ccgctggata atacaagtct ggttactttt tcatagtcat gagaaagtcc cgactgttca 1799341 taaacaggct ggaagcggct ttcgctgagc tcctgcactt ccgacaccgt atttgggttg 1799401 cgaagaaggc tcttcggcgt cataatgacg agcggtctga tttcttcacg aagcagcatt 1799461 ttagcctgtc ttcttaaaat atggaaatac tgtgccgcgc ttgtcaggtt ggcaaccgtc 1799521 cagttgtttt ccgctgcaag ctgcaggaat cgctcaattc ttccgcttga gtgctcaggc 1799581 ccctgtccct cgtaaccgtg cgggagcagc atgactaatc cggatttttg gccccatttc 1799641 gcgcgtccgg cagaaataaa ttggtcaaaa tacacttgag cagcgttggc aaaatctccg 1799701 tactgtgctt cccacaaaac aagcgtttcc ggtgaatgca cgttatagcc gtattcaaaa 1799761 ccgagaaccg atccttcaga cagcgggctg ttatgaacag caaatgatgt gctgcagtca 1799821 gataagtgat gaagcggcac aaattctttg cccgtctcac tgtcatgaag cacaaggttt 1799881 ctttgggcga acgttccgcg ctcggaatcc tgtcctgtta aacgaatcgg tgttccgtct 1799941 ttcaaaattg aagcaaacgc gagtgattct gccaaagacc attccacttt tctgtcatca 1800001 tcgaacgcct tggcgcgtct ttctaaaatg cgctttagct tgccgaaaac attaaatgac 1800061 tccggccagt tgatcaattc gccattcagc ttgcggagca catcaaaatc aatcgaagtg 1800121 tccacatctg ggaaaccgtt tgatacaggc tctggaagtt caatttcaca agcagtgtgt 1800181 tcctttttag acggaacttt ctgatatgca tcctcaatgc gcttcgttac cgatttttcg 1800241 atgttttgaa cgacttcctc ggtaaccacg ccttctttta ccagcttttc agcgaaaatt 1800301 tgtttgacgg tcggatgctt tctgacagca tcatacagca ttggctgagt ggttgacggt 1800361 tcatccattt cgttgtgtcc atagcgtctg tacccgatca aatcaatcag aaaatccttg 1800421 ttgaatgttt ttcggtattc gaccgcaaac ttaacagctg aaagacaagc ttcaggatcg 1800481 tccgcattca cgtgaacaat cggaatttca taacccttgg ccaggtcgct ggcatatttt 1800541 gtcgatctgg attcagcgct ttctgttgtg aatccgatca tgttattggc gataatatga 1800601 atcgcaccgc ctacttgata cccttttaaa gagcttaaat tcaatgtttc agctacaatt 1800661 ccttccccag ggaatgcagc gtctccatgg attaaaatgg ccagcgattt tgtttcatct 1800721 tgtaccgggt atccgctttg tgttcgcgtt tcctgtgccg ctcttgtgct gccttcaaca 1800781 atcggattga taaattccaa gtggctcggg ttgttcgcta acgtaatgcg cgctgatttt 1800841 gtttcagcgt cttgaagctc ccgattcgcc cccaaatggt atttgacatc ccccgtccat 1800901 ccgtagctga ttccaatgga tccctcagac ggtacaagat ctttgttcgg cgcatgctgg 1800961 aattcagaga agatgatttc atacggtttg ccgagcacat gtgccaagac attcaggcgt 1801021 cccctgtgcg ccatcccgat gttgacactt gtcgtgcctg atttgacaga ttgtgcaata 1801081 atgtcatcaa gcactggaac aagagcgtcc agaccctcaa tggaaaagcg cttctgcccg 1801141 acgaatgtgc ggtgcaaaaa ctgctcaaag ccctctactt ctgtcaatct ttccagcaca 1801201 gctgacagct tttcagctga gttcttctgg aacagctcgc cagattcaat ctttcttgtc 1801261 agccactcgc gctctttgaa gtcatgcaca tggtcaaatt caaaagagat ggttctttta 1801321 tacgtatttc gtaaatactg aatggcttct aaaccgttcg aaatgttttt aggagcgtct 1801381 ttgcagatga cagacgcagg tattgctttt atttcctctt ctgttagccc gtaatcggat 1801441 aatggaaaaa gttcgctctt tttctcatcc tttctgagcg gattgacgga agcgttcaaa 1801501 tggccatagg ttcggatatc ttctgcaagt ctgactgcgg atgcgatctt ttgaatcaga 1801561 tcggctgtaa cacgtccctt ttcttttgtt cccgaggcct cttttatatc gcttggcgga 1801621 gcaccgagct cgtcgaacat ttccttcaaa tccgggtcaa tgctgttcgg atcctgggta 1801681 tactgatcgt aaagctccag cgcatagccg aggttcggac cgtaaaaatc ttcccaattc 1801741 attcgttgtt tcatactatt ttgaaacatt tgaatattac ccccaactta aataatcaag 1801801 tgattgattc actatcttga aataactttc gaacgctgtg tccaaaatta tgtaataaaa 1801861 acgcttccaa cgatatttta ccactgtttg caatttgatt ctaccttgat tgttcacaaa 1801921 atagtaaaaa acctttataa aaaacaaaaa atttaatcat tcgaaaaaac aaacgccaaa 1801981 aagcatagga ttaagggcta tcctatgctt ttatgaagca gttttttcag cagcggatac 1802041 aaaacatccg gtagctgatc aacatccggg acaaatatac tgaattttcc gtacatatcc 1802101 tggatcgtct tcatttgcga ttcttctatt tctgagttgg agagaaaaac atttatcact 1802161 tctattcctc tttttcgggc ttcgataacc gcctcacttg tatcaacgat cccattttgt 1802221 tcgtagccaa atgcggccgg ctctccatct gagaaaacaa ttaagaactt ttgcgcctcg 1802281 ctgcgatgca gcattttttt cgtcatctgc ctaattgcgt acccgtcacg gttatcttct 1802341 tctggctcaa gctgcataat ggccggtcca gaatcttgtc ttaatgatga ttggaaggga 1802401 ataaccgtat tgaaatagtt tggctggctt ttttcggttg catcatttgt gtcctcccaa 1802461 aaaccgacaa tctgatgcgg aaccgctacc gatttcaacg cttcgtgaaa cagcacgatt 1802521 cctcgttttg tttcgtccat tttgtcgaac atgctggcgg aacaatcgac cagcaatgta 1802581 aaaactgcgt cgatttctga agatggttct tgctttttgt agaacaggcg cggatttcgc 1802641 tcagtgaagt aacgaagaag cttattgttc agtctcccgg catgaaggtc tgttctcggc 1802701 aatgtttttt tatgctccag cgttttttga atcatttgtt tcaaacgctt ttgatacgat 1802761 tcaatcgttt ttgcctgctg tttataagaa agctcttctt cactggttgc cggctgcggt 1802821 tctttataaa ttggaaatgc atatttattt tctttgccgt cagccatacc cgctccgttc 1802881 ggctggtctt tttgggactc cagcgcttcc agcttggaat agtctttccg tttcgtttgt 1802941 ctggctgatc cttgaacaga gccaagggcc tgatctccat cgtcgccttc ccttgaagca 1803001 tcttttccta aatctgattt tgcgccgtgt tcaatatcaa attgaaggaa gcttttagac 1803061 ggtgcttctg tttcccggtg ccatgtcggc atttcttctt catggatatc ctcatcaccg 1803121 tctgattgtt ttggaagcgt gatgtcatca ctcagcttcg gcgctttttt ctcttcttca 1803181 aataacggct gttctgcagc ttttgcgtaa tcaagctcag gcaaaaagaa gtaggtgttc 1803241 aacatgtctt tatcgagtac ctcttcaagt ccgtccatga ggtcctcaac aattttcaga 1803301 acctgccgtg tcgaatctgc ttcatacaca cgcaagagct gctgctcaat aaacgggcgc 1803361 atcagatcga tatcttcacg catggatgga agggtctcga gcggcgattc cgctgtgagc 1803421 ttgaaataga tcgcgcaaaa gagcgcatcg gtaaaaatgc ttcgttccaa atttaaggtc 1803481 agctgggttg agaaatgttt tctgtacatg tcttttcgct tcgcaaatac atgtttcgta 1803541 cccgggcgct cacgtttgat gcattcttcg atcctaatgt cttcaagcag cataaagagc 1803601 tgcttggcaa aacttttaaa cgtaagatgg cgatggatat cattcaaaaa gttcgcaaac 1803661 tcatgcagcg agctatatct tgttccgact gaacgcaggt agacgtcgct tttcagaccc 1803721 gcttccatgt cctcagctgc cctgtctttc caaaagtggc tcatatagat tttcttttca 1803781 aatggattgt aataggactg aacgccatac tccacttcta ccgcttcact cttggtgagt 1803841 gttttggcca aatcagtcag catcataaat aaaaatgaat caatcgtgct gtcgttaaat 1803901 ttgataaatt tcatcgcagc cccctcattc aaacagagtt tctgcaatat ttcggacagc 1803961 cgctttttcc cgatcatcat caagcttttc tacaattccc cgctcaatgg cacgacgcgg 1804021 cggaatataa gcagctaaat cacatgtatc gattaaagct ctgatggatg ccgcttcttc 1804081 agacacctgt ccgttattgg cctgaacgat caagtcagag gaaagcgtga taaatctgtc 1804141 aatcaatttc tcgtctttca aggctgactg agacatgagc acttgtttca gcagctcgcc 1804201 tttaatataa ggcacatcaa tgatgacaaa acggtttttc aacgcttcat tcagaggaac 1804261 agttccgaca tagccttcat tgatggctgc aatgactccg aaaccgcttt tagcccgtat 1804321 gacctcgcct gtaaacggat ttgtcatcat ttttctgtaa tctaatacac cgtttagaat 1804381 aggcagtgtt tccggcttcg ccatattgat ttcatctata taaagaaaat ggccttcctt 1804441 cattgccttt gtaacaggtc ctgaaacaaa ctcgattgtt gcctggccag attgattttc 1804501 aatcgtttta taaccgacca atgcctcagc gtccaagtcg actgaacagt tgacgctgtg 1804561 catcggttta tgaaaatagc tggacaatgt ttctgccagc tttgtttttc ctgaacctgt 1804621 aggccctttc agcaggacat ttttccccat ggctaatgca ataatggcgt caaataaaat 1804681 ggcttcatcc tccgcctcat agcctgatgt tcctataagc gattgaaact ctggggaaat 1804741 aggctgctct ttatatgata aaagcttttg ttgtatatct tccggcaatg ttaagtgctg 1804801 tagttgagtt gtcatagaca gattcccttt cctattcata ttccattaac gagtatacta 1804861 aaaaagcccc tgtatgctca atacaaaagg gcctggatga tattactgct tctcgttatt 1804921 tcccaaaagg gctccgcaga caatacgcgc accggaattg ccgcttgggt ttgtcagata 1804981 atcgtccgct tgttcatgaa taataaatgc acttccgtcc tcgtcgagaa tatttagttt 1805041 acttcctttt ttcagtgaag tgtcaggcgc attcattatg acatctacct ttccatcagc 1805101 accgacttca aggttcggca gatctccggc atgatgcccc atcggattat taaagccgtg 1805161 ttctttgttc agtggattaa agggaccgcc cgctgattca aaatccggcc tgacacaaga 1805221 acctttctca taaatatgaa aaccgagaga agcacctgga cgcaggctgt ttgcggaaat 1805281 atgaatatcg aggccttcat catctgattc tttgatctct ataaaaccga ctgctttccc 1805341 ttcacgattg accagctgga catgatgacc aaacgctgac gtttcaacca cttttttttc 1805401 cggcacccgg ttaggagggt ctggaggttt tttttgtccg catccggcaa ctcccagtgc 1805461 cgtcagcatc atcaacagca agagacggtg catactgtct cccccttgtt ttttctaaca 1805521 gtgtggtcaa tcattgtctg gtataaacaa aaaagcctat aaaaggcttt ttgtcatact 1805581 catttttaaa aataacttct tgcgcccaag taccgctgtt tccaatacga attgctgaga 1805641 ttggaaatgt cgacgcccga tgagcttgca tgaataaaat caccgccgcc tagataaatc 1805701 cccatgtgag acgggccgga tttatatgtg gtaaagaaga caaagtctcc tactgacggc 1805761 tggctgactt tctgcatgac attccaatac cctgccgtac tcaatcttga tatagatgat 1805821 acattattaa tgaggtaata aatgaagccg ctgcaatcaa aaccggcagg cgtgtttccg 1805881 ccccatcggt aaggcactcc gacatatttt ttcgcttccg ttatcattct gtcaatcttc 1805941 gaacctattt gaatgtttga ccctgagtta tcttttggct ttgttggctt tgtcggattt 1806001 gaaggattag attttgatgc tcccgaaata gtcagaacct gcccgatttg caacacatcc 1806061 gatgataaat tgtttttatc acggatgctt tggacagtga ctccgagccg atttgcaatt 1806121 ttccacagcg aatcgcctgc ttttaccttg tacgtcgttg tttttgaggg attggagttt 1806181 gacggctttt tggaaccgct gtttccgttc ttaggtgaac tgcttccttt tattttgagc 1806241 acctgtttag gataaagtgt atctgatgtt aagccattta aggtttttaa ttcggctaca 1806301 gtcatattta agctgtttgc gattttccac agtgagtcac caagcttgac cgtatatgta 1806361 ctttttgaag aacctgaaga attggaaccg ctgtttttct ttgatccatt tgatccgctt 1806421 gaactgcttg tccctttgat cttaagcttt tgccccggac gaatcaggtc actgctcagg 1806481 ctgtttaagc ttttaagctc agaaacactc attttatgat ttttagcaat catccatagg 1806541 gaatcaccat atgcaactgt gtatgttgat gttttgcttg aattagatgg ggatgtcgtg 1806601 ctttttttgc tgctttcagg aaccttaaga ctttgtccga cataaagcac cgttgatttc 1806661 aatttgtttt cggatttcag agctgatatt gtcgtatcat actggcggga aagtttccaa 1806721 agagagtcac cgctttttac ttttatcgtt tttgcttccg cgggtgctgc ggccatcgac 1806781 gacccaacaa ctgcagaaac agccaagccg gctacaatct tctttttcat tcattcaacc 1806841 tcctaaactg tttttttgca aaaacagcta gtattttgtt tccaaaaatg gcacacaact 1806901 gttttatcgt caatttttca gcaagttaaa cccttttcaa acatttggcg cagcattttc 1806961 agcatcgttc gacctttaaa ccttcaaata aacatctaac attttacata agcacgatat 1807021 gtttttcgaa agtctaagga actatttaag cgagggtaaa aatgatggtt ttctattgat 1807081 gaacgaagca gtttctcctc ctttcttgtc tatttttcta atcaattctc tatcggcgtg 1807141 tcaaatccct tcctctgcat tcttatgaaa tggcaaaaag cctgttcttt cgataagaac 1807201 aggcttttac actatgcatt tgctgattga gttttttgtt ttacagcttc aagaatgctg 1807261 tcggctgctt ttttagagcc gcctgccgct ttcagtgatt gtccaatttc ttttgccttt 1807321 tcagcatacg aacgattatt cattacttct tgtatcgtct ctttcagtag gctttcagac 1807381 aattcttcct ttttaattac ttttcctgcg ccgacttttt ctacctgatc tgcgacaaca 1807441 aattggtcgc ctcccatcgg aatgacaacg agcggggttt caaaatacaa accttcactt 1807501 gtgctgttca ttccgccgtg ggtcacaaat aagctggctc ttttcaagat ctcaagctga 1807561 gggacatacg ggcgtacaat gaaattctcc ggaatgtcgt ttaactcact tgttttaata 1807621 tgcttgccga tggaaagcac aactttaccg tcaaagtcct tacacacttc aaggcattga 1807681 ttaaaaaact gcttttgatt attaaaaatg gttcccattg aaataaacag cacgttttca 1807741 ttgtcaatct gatcaaatgg gaaatcattg tttccggctc tttctgtaat ggaaggaccg 1807801 acaaatacat atcgctcgcc aaattgctca gccagtggct gaaatcccct tgatgtaaag 1807861 acgattgtca agtcaccatc agctaaaaaa acatcaaatg gcttcttgat ctctgcttga 1807921 aaatcagcat ttaacgtttc tgcaagctgc tggtatgatt cataatgagg cgaatcttca 1807981 agtgatcctt tcatgtacgc tcccatcatt tccttcgcaa attcctcatt catcgcaaag 1808041 gttgtacaca atgaaaatct tggcagcttc agcatgttgg caatgacttt acccgcgaga 1808101 agatggtgat catatatgac ataatcatac gattcatgtt tgacttcctc ataaatatga 1808161 gtcgcgatat ccttacaggc tttcaaaaaa gcgcagagca tttctgtgaa atctctttct 1808221 tcatcgccgg ttgcgttttt cccgaagtaa tctcctctga aatcatgata ctcacgaaac 1808281 tctatatcaa gagctgtgat tttttcttta tattccttca ctgcgtagta cgtaatgttt 1808341 tctccccggg atttcagctc cttcatcaca ccgatagagg gattaatatg cccttcaccg 1808401 gggaaaccga tcattaatac attagccatg cggcagcacc cttcctttga gaatttatgt 1808461 aatattttat acggtactat aaatgcataa acaggtaaag tatttcactt aattaatatt 1808521 catcatatat aacttttcta ccagtttata ttccctgtct tcaagacaaa aagcattcag 1808581 cttgaagcga atgctttaat aaagatgcga attcagtcat tttgtctcat gataggattc 1808641 ttaatcaggc cctttttatt atttttacgt tcttggtgaa attaacggat ataatacacc 1808701 gtctttggca aacgacatct tccctgtttc ctctgaaacc acgagcacca gtgcatccgt 1808761 atagcccgac ataccaagag ccgcccggtg ccgggttccc aaatggatat ccacttcctt 1808821 cgtcgtcagc gggagcacat tggctgctga cacgagtttg ttttccctca ctaataaagc 1808881 gccgtcatga agagggtttc cgggaaaaaa gatgctttca attaatgaag agctgatctc 1808941 ggcgtgtagg gaggtgcctt tttgaataaa acgttcaacc gggtctgctc tttcaatcac 1809001 aattaaagct ccatgcttat gttccgataa ggctttaatc gccttggcca gctcaataaa 1809061 tgccggcgta aattcctcaa tgtatgattg caaataaaag gaggatgcaa tcccctgcat 1809121 gtcctgaaaa acgtgcccca aatcatctaa ttcacaaagg agacactggt ctttttcgtg 1809181 aagcgttttc aagattagag atgcatcacc taatatttgc tctaagtaca cctgtatttt 1809241 ccccttgaac gcattttctg atatctgctc atagcgcata gccttcatct cctgtttaaa 1809301 tttccaactt ttcacgaatg cttatcttat tgatgcacat tctattggta aaggagggat 1809361 gtaaagaatg gaaatcgaaa gaatcattca gtatatttgc acctttttag gcgtgatttc 1809421 gctttctttt atttatgccc aaatgtttag aaaaacgaaa ccgacaaaaa aagaataggc 1809481 ccggcgttca ttgcttttta tacataaaat gttataattt ctctcgttat gaaaaagaaa 1809541 cggagatcaa tgtatgaaag aaactcaaaa cgcccgggaa aaaatcaaac agctcttgca 1809601 cattttaata ccgatattca ttacccaagc ggggctttct ctgatcactt ttctagatac 1809661 tgtgatgtca gggaaagtca gccccgctga tttagctggt gtcgccattg gctcaagcct 1809721 ttggacccct gtttacacag gacttgcagg tatattaatg gcggtcaccc cgattgtcgc 1809781 tcagttatta ggtgcagaga aaaaacagaa gattcccttt actgttttac aagctgtata 1809841 cgtggccgcg cttcttagca tcgccgtttt agtgattgga tatgctgcag ttgaccttat 1809901 tcttggccga ttgaaccttg atattcacgt gcatcagatt gctaaacact ttttaggctt 1809961 tttatcactg ggaattttcc ctttatttgt ttacaccgtg ttgagatcat tcatcgactc 1810021 attaggaaaa acgagagtca ccatgatgat tacactcagt tctcttccaa tcaattttgt 1810081 attgaattat gtatttatct tcgggaagtt cggaatgccg gcacttggag gtgtaggcgc 1810141 gggactggca tccgcgttaa cttactggtg tatatgcatc atcagttttt tcattattca 1810201 taaaaacgca ccgttttctg aatacgggat ttttcttacc atgtataagt tctcttggaa 1810261 agcatgcaaa aatttgctca aaatcgggct gcctattggg ttcgccgtgt tttttgaaac 1810321 gagcattttc gcagctgtca cgcttctcat gagccatttt catacagtga ccatcgcgtc 1810381 ccaccaggca gccatgaatt ttgcgtctct tttatatatg ctgccgctta gcgtgtccat 1810441 ggctctaaca attgttgtcg gatttgaagc gggtgcagcc cgttttaagg atgcacgctc 1810501 atatagctta atcggcatca tgatggcgat cggcttttct ttgttcactg ccgcctgtat 1810561 ccttttattc agagagcaaa ttgcgggcat gtacacttct gaccccgatg tgctccggct 1810621 gacacagcac tttttaattt atgcgctatt ttttcagctt tccgatgctg ttgccgcacc 1810681 gatccaggga gcactcagag ggtacaaaga tgtgaactat acgcttgcgg ccgcttttgt 1810741 ctcttactgg gtcattggcc ttccggtcgg ttatatggtc ggtacgttta caagcctcgg 1810801 tgcattcggc tattggattg gattaatagc gggactcgcc gccggagcag ttgggctgtt 1810861 tttcaggctg gcaaaactgc aaaaacgtta ttcgcaaaaa caacacattt aaaagaggtg 1810921 atcaatcatg gcaaaaaaca aaaaattatt cgagtatctt tcccagcatg cggaaaccat 1810981 cagttcaaca tggtatgaaa caatcgagga gactgatccc aattccattt atgcctcaac 1811041 agaccctgtt gtcattcaca atttaaagag ccagaatctt gcctttaact ataaaataaa 1811101 ccgtattttt atagatgatg aggacgtata cttgcctata ctgaaagaat gggcctttga 1811161 agtcacacag gatcaagagc atttaaaaac tcctatccac tatattattc gggagtttgt 1811221 cagagtgaga gatttatatg tttcttatgt gaaagaattt gtccatctca atcagaatac 1811281 tgtgaaaagc gaagaagccg aagacctgta tcacgccctt ataaaagcgt ttgatcttgt 1811341 gattcatatt tttatagaag aaatgtacaa aaacacaagc cttcagcttc aggcccaaaa 1811401 agatatgatt actgaattga gcgctccggt catcgtgctg tttcacagcg tcggactgct 1811461 gcctttaatc ggagatattg atacagtccg cgccaagctg attatggaaa acacactgca 1811521 tcaatgtgcg aaaaaaaagg tgacacaact gtatattgat ttgtcaggag tagctgtgat 1811581 tgatacgatg gttgcccatc agctgttcag tctgattgag gcgcttcgtt taatcggtgt 1811641 ttcttcaact ttgtctggaa tccgtccgga aatcgcgcaa acagcggttc agctaggttt 1811701 gtctttcgaa ggtatttcct tgagatccac tctcgcttca gctattgcat cggacttaaa 1811761 attaaaaaag gtataaggct taaggcctta tacctttttg attaatcatt ccattgatac 1811821 gtccaatata tttcttcttc aaaccatgtt gccataacag gttcattatt tttcaatttc 1811881 tcttcaagct ctctgagcat gccttctgtt tgtgtgcggt gagctcttaa cgcattcatt 1811941 ttaatatcag ctacttcttt gatatcaagt acgacatcag cttcgccgag aacctcttct 1812001 ctgttgcggg taatggccat gcagattgta cgcggacggt cttctttctt tttgcggtat 1812061 aatgcacgga taaccgcttc cccgcatgca tcatggtcag ggtgcacacc gtgtccggga 1812121 taaaatgtga caattaaact tggttttaca tcatctatga tctcttccat gatatcagct 1812181 aaatactcat cgtcttcaaa ttcgagcgtt ttgtcacgga gtccaagcat ccgaaggtca 1812241 ttgatatcca tttctttgca agcgttgatg agctcttgtt ttcttagcag cggcaacgtt 1812301 tcccgattcg cgaaaaatgg atcgcccata tttctgccca tttcacctaa agtggcgcag 1812361 gcatacgtaa cgggaatgtc tttttttctg tttaaggcaa tgaggcctgc cactccatat 1812421 gattcatcat cagggtgagg caggattact agtacatgtt ctttcattat tattcaccct 1812481 tttctttaaa ctgtgaacgg tttttcgctg atttgcagag aaatagccag tttaccgccc 1812541 ggcaggtgtc ccgccattaa taaacggttt tcttcatcta ccgtgtattc agtcaagcct 1812601 tcagcataaa tccagccttc ttctgttttc aagccaacgc ggtaaggccc gttgcctttg 1812661 atttttgcct gatgataagt gacttttgca ttgcgaatat acgcaacaac cgtcatgttc 1812721 ttttcattta agtgcgctga ataagaacct gtggtggttt ctaaatggat atatacaggg 1812781 cggtccgcat atcgttctaa agatgcttgc acatcttctt ttatgatcgc tttcatgatt 1812841 gctcccctct ttcttctttt aaatactctg cacgttctgt atgtaatttg accagctgat 1812901 atttcacagc cggttcgagc tgtgaattca caatgcgctg aatcgcggca aaatattttt 1812961 ccagcatcgg ttttcggagt cttggatgtg ttcgtttatc caagagctca agatcaatcg 1813021 cctctgctac cgcttctgcg tcatcatgtg cgagagatcg gttattccaa agtgaagcat 1813081 aggctttcac tatctcttta tcattgtcca tcgtcttgct cctttatgtc ttacatacat 1813141 gaaatgatta tacataatat atgcatcagc tgaaaagcca aaggcctcaa tggctttttg 1813201 acgcccgttt ccacttcact tgtgaaaacg taaacaagag cagcgcagcc catatacagc 1813261 tgaatgtaaa agccttcgag cttgaaaatg gctcatggta aacaaacagc ccgatcagca 1813321 gggtaatggt cggcgcaata tattgtaaga taccgacttg atacagtggc agccgtttcg 1813381 ctccttccgc aaacaataag agcggcaaag ccgtaaacac accggccaaa aagagaagca 1813441 gccacgtccc tccgctttct gcacccgctg gctgaacatg tccgctgaac agcaaatacc 1813501 ccaatgcaat gggcataatc atgaatgttt ccagcgttaa accgatggcg ctcggcaggc 1813561 ttgttctttt tttgcttaac ccgtacagcc caaagctgaa tgcgagcaga agcgcaacat 1813621 aaggaatgga gccgtattgg aacgccgaga tgatgacacc ggctgccgca atcgaaacgg 1813681 ccactaattg caggcgattc agtttttcct ttaaaaataa aatcccaagg agcactgata 1813741 caagcggatt aatgtaatag ccaagactag cctcaagcaa aaagccatgg ttgacagccc 1813801 atatgtatac aaaccagttg atcgaaatca ggatagaagc aagaaataaa gagaggatcc 1813861 ctccgttctt tttcagagag cgcaactcct gccatcctat tttccattgc cgcaagaaaa 1813921 aaagtacgat acacataaaa acaaaagacc atataatacg atgagccaaa atatcaagag 1813981 ccggcagctg ttcgagaagc ttccaataga gcggaaacag gccccacatg ataaatgaaa 1814041 cggctgtgta aataacgcct ttttttgttt ctgcatgttg cattgatatc cctgcctttc 1814101 tttagagcat cttatattat atcacgtgaa agatctggtg ggcatatact attttgtccg 1814161 tgaagaaagg atgtgaagac aatgtttgag tggaacaagt actttccttt ccacaatcaa 1814221 ttttctaaag aagcattaaa aaaagctgat ccgaaagaag ttgaaacgta tgtcaatcgt 1814281 gtgatggaaa gtgtgttcgg cagtgattat gcggctcaat ttcctttccg cgatcctctc 1814341 ccccaaaaag aacatcccgc caaacctgat gcaaaacctg atgtcaaacc tgatattgat 1814401 atattcgaaa cagcagacca tgtgtttgta aaggtgccaa tcagcgaaga atggctggaa 1814461 caagtgagaa tcaaacacac atctcacgaa ttatggttgg aaaacctccc aagagcagat 1814521 catccgaaaa aagtaaacct tccttgttta gtcaaacgca aaggaacaaa agccgtctat 1814581 aaggatggcc ttctggaagt catgtttcaa aagcagcaag actacaatat gtccgaggta 1814641 gaaatcatcc gataaaaaac ggcctgcaat cgatgcaggc cgttttttat taatagaagc 1814701 cgggatatcc cccgtatggc acgccggcac caaaaccgta cggtccgcct ccatatccat 1814761 aagggccagg aggataggca tagggacgag aatagttaaa cagcgcactc ccgagaaaac 1814821 cgcctaataa accgccgact agaggagcgc caaacaaaaa aggactacgc gccggatatc 1814881 cggctggacc tgggattccg cgtaaatacg aatgatgagg gtacatgatt ttttcctcct 1814941 ttatgtctgc ctatacgtaa agtattcagc aaggaagaaa aacgattggg ctacggactg 1815001 tctatgattg ttacatcaca agccctgcca ataacacaca gccgagccct gtaaccgaaa 1815061 gaactgttgt aagcagcgtc caggtttgaa atgtttcttt catgctcaag ccgaaaaatt 1815121 cctttaccat ccaaaatcct gcatcattta catgacacgc aatgacactg ccggctcctg 1815181 ttgcaagcac cattaacgca gggtttacac tgccagcctc cataagcgga gctgccattc 1815241 ccgctgtggt aagcgcagcc acggtagcag agcctagaca cagacgcaga accgcggcga 1815301 tggtccatgc aacgaatagc ggcgacatgt ttgtttgacg gaaaaaatca gcgacataat 1815361 cgccgactcc gccgtcaatc agcacctgtt taaacgctcc tccccctcct atgatgagca 1815421 gcatcatcgc aatttgcgaa attgattctg aaatagatct gccgatttcc tgcatagata 1815481 ttttacgggc atatcccatc gtatagagtg caagcaacag cgaaatgagc attgccgttc 1815541 ccggagtgcc gataaattct ataatgtctt ttccttttga atgttcactc aataataaag 1815601 aaaaaattgt tgccattgcc ataaagataa ccgggaataa agacgtgaca gcactgatcg 1815661 caaagcccgg tgtttcatcc agctgaaatt ctttccttgg tcctaacccc gataggtttc 1815721 catgcttttg atacgcacca ggaaaccgtt tcatcgcaaa tttattaaat aaaggcccgg 1815781 caatcacagt tgtcggaaca gcgatgatga ttccaaaaag cagcacctgg ccaatatggg 1815841 caccatatgc aactgagata gcagttggag caggatgcgg gggcaaaaat ccgtgagtaa 1815901 catttaaggc ggcggccatc gggattccca gatacagaaa aggcattttt aattctttag 1815961 caatcgcgta aacaatcggt atcaacagaa caagaccgac ttcaaaaaat agggcaatcc 1816021 cgatgataaa agaggcaacc acaaccgccg cctgtattcg tttcctcccg aatttgtcaa 1816081 tcagcgtaat ggcgatccgg tagccgcccc cagcatctga gacaagcctc ccaagcatcg 1816141 cgccaagtcc aaacactaaa gctaaatgcc ccagctgccc gccaattcca gtctcaattg 1816201 aaagaacaat tttattgata tccattccaa gtccgatggc tactaaaaat gaaacgacaa 1816261 tcagtgagac aaaggtattt aattttactt taataatgag aaataacaga atcagcactc 1816321 cgacagctac aattaaaatc ggcatggtac ccctccaaaa gtgttttata tgattctcgc 1816381 gacaatgttt tggcgctttt catgcctaga tgaacagaaa gcgctttcat taataactaa 1816441 aaacgtcttg gttatatgat tgttatcttt tgatcaacta atatgttcat actaatctcc 1816501 taatcaatga ctgtcaatcg tttttatgag cttgtctcga ttacctaccg cctaacccaa 1816561 tgatttatta gttatatgtt gattaacttt tggttatatg ttatgttttt taaagttgac 1816621 tgccaatcat tatatctctc cattgtctgg aagcaaatga gacaatatga gaacagacgg 1816681 ataacaactt cataagagga ggagtacaca tgccattatt gcgttttgat gtaattgagg 1816741 gccgtgatga aaaatcgctg caattgttat tagatactgc tcaccaagcg atggttgaag 1816801 catttggtgt tccggaaaga gaccgttatc aaattgtcca tcagcatccc gcaaacgagc 1816861 ttataatcca ggatgcggga ttagggtttc agagaaccaa ggatatggtc atcattagca 1816921 tgacaagcaa agcaagaacc gaaagccaaa aggaaaaatt gtatgctctg cttgctgaaa 1816981 ggctagaaaa aaaatgcgaa atttcccctg acgacctcat ggtatctatt actgagaatg 1817041 gtgacgcaga ctggagtttc ggtctcggtg aggcgcaatt tttgaatgga aaactataag 1817101 atttcgtctc cccacaaaaa aaagaagaga gagctccaaa gaagctctct cttttttcat 1817161 aaatgcggaa gtcatcagta tagaagcatc cagcaatacg aaaaacctgg atctcctttt 1817221 atatccggtt taaatgccaa ttggaagctg actgggtttt ggctgaaaat ataaaatttt 1817281 gctgatttgc ataataagat acatcataat ccccatttac aataggttgg atgttatagc 1817341 ttattgatca tttcctattt tatatatccc cttcatatgc acatgacatt tttgccaatc 1817401 cggaaatatc agtctgacaa atataaaaag tcatgtaaac gggtgtgaac cgtacttaca 1817461 tgactcacca tggaaacaaa ggctcttttt caggtgccgc tttccttatt tctcttcttc 1817521 acacactgtg tcaccaggct cgcaaaattg atcggcccat gcctgcattt cttgaaatac 1817581 agcttgaagc gctgttcctt tttcagtcag cgtgtagatg actttgaccg gcgtttcagg 1817641 gagaacctgc cgttcgacaa tctcgttttg ttcaagctcc ttcaagcgct ctgccaacat 1817701 tttttggctg atcatcggta ttgtttccgt tatctcttta aaccgtttcg gcccatccat 1817761 tagcacatgg atgatcagac cgttccatcg ttttcccagc aatgagaatg cggattccat 1817821 tttagggcac atcgtatttc ccataagtct tcatcccttc atctattgat tgacatgtat 1817881 tcaatgatcc attacaataa tctttcaagt tacatttagt aagcttctaa cttttctatt 1817941 atcataccac gtttatccga aggaggaaac actatgacga atactctgga tgttttaaaa 1818001 gcacgtgcat ctgtaaagga atatgataca aatgccccga tctctaagga ggagctgact 1818061 gagctattag accttgccac taaagcgcct tctgcttgga accttcagca ttggcatttt 1818121 acagtattcc acagcgatga atcaaaagcg gagcttcttc ctgtagcgta taatcaaaaa 1818181 caaatcgttg agtcttctgc tgttgttgcc attttaggcg atttaaaggc aaatgaaaac 1818241 ggtgaagaag tttatgctga attagcaagc caaggctata ttacggatga aatcaaacaa 1818301 acattgctcg gccaaatcaa cggtgcttac caaagcgagc aattcgcacg tgattccgct 1818361 ttcttaaatg cttctttagc tgctatgcag cttatgattg ccgcaaaagc aaaaggttat 1818421 gacacttgcg caatcggcgg atttaacaaa gagcagttcc aaaagcaatt tgatatcagt 1818481 gagcgctatg ttccggttat gcttatttca atcggcaaag cagtgaagcc tgcgcatcaa 1818541 agcaaccgtc tgccgctttc aaaagtatca acttggctgt aaggatatga aaaaccttag 1818601 tccgaaatcc ggactaaggt ttttttatac aatcgcctct ttgtaccatt cacgagcctg 1818661 ttcagcttca tgctgagtca gctgatggcc cccgtcctgc cagtaaacgg aggctgatgc 1818721 cccgctgtca cgcaaatagc ggtaaagctc ttctgattct tccttcgtgc aaagaggatc 1818781 gtatttcccg gcaccgataa aaacagggag ccccgccata tcaggcagct cgataccccg 1818841 aatcggaacc attggatgat gcagaatagc cccttttaac acatctttat aatgaaaaag 1818901 caggcttgcc gcaatgtttg cgccgtttga ataaccgact gcaatcactc ggccgcgatt 1818961 aaactgatgc gtttctgcag cctcgtcgat aaaatctttc aattctcttg tccgcaccac 1819021 aagatccttt tcatcaaaaa ctccttcact cagacgtttg aaaaatcgcg gcattccatt 1819081 ttcaagcacc gatcctctga caccaagcaa atgggcatca gggtctataa accgccccaa 1819141 tgaaagcaga tcgtgttcat taccacccgt gccatgcaac agcaaaagta cgttgtcaga 1819201 tgttcctttc tcataaatat gcttcattat aaattccccc ttttaaagtt caggtaaaat 1819261 gtctgtaatt tgttgtctat gtttctccag ccattcaggc agttttaagg aagtccctag 1819321 ctcagcaaac gtttcatctg tcataaagcc cggttcatct gtggcaattt caaataagat 1819381 accgcctttc tccctaaaat aaactgatgt aaagtattcc ctgtcgagaa tttctgacga 1819441 aggcagatgg ttttcagcaa taatcggcag ccatttcgcc tgttcctttt tcttagtccg 1819501 aaacgctaca tggtgtaccg taccatatcc tccgactcct cttttttcag gatgtaaatg 1819561 gacatcaatg acaccgccga ccgccgctga agatgccagt ctgacaatct ggtcttcttc 1819621 ggccactttg gtgtatccaa agctttccgt taacaattgt atggtcgcct gcgggtcgta 1819681 ggaatatagc agcacacctt tcattcccgt aattgcttca tttgttgtga tcccgtcagg 1819741 cgtccactcg cttttgccgc ttttcgcatc ctccatgatc gccagcggaa ggtcttctgt 1819801 atcatcaaaa ataagacctt tttcaccaaa caacgttttt tcctctaggc tcagcccgct 1819861 tttctcaaga cgttccttcc aaaaagacag ggagcctgag ggaactgaaa agtacacccg 1819921 gcccgcttgg ccttttccta ccgttccctg tccgcttcct tggaacggaa aaaaggtcat 1819981 tattgtaccg ggatctccgt tttgattccc aaagtaaaaa tgatacgttc cgggatcatc 1820041 aaagtttact gtttttttaa cgagcctgag cccaagcact tctgtataaa atcgcaagtt 1820101 ttcttgcgga tctctggcga atgctgtgac atggtgcaat ccttctgttt tcattttctc 1820161 actcctattt atctcgattt caagatattt attattttaa acctttattg aaaaggatgc 1820221 aaaccatgtg ttttgattaa ataattgaaa aaatcatttt tttctaataa ttatcttgtg 1820281 atcttttctt acaactgcta ttatagtgag cattatcatg tttcaggagg aaagtaaatg 1820341 gttaaaaaag cacttattgt tattctcatt cttttgccat tcgttcagct cgcgcttttg 1820401 ccgcttgtga atcgaataga accgattatg ttcggcctgc cgtttttcca cttttggctg 1820461 ctgctgtgga ttattgttac gccgttatgc tcgtttggca tttatcagat gcaaaaaaaa 1820521 gatggaggac ttgaataatg caagggaatc tgactgcact tctcattact gctattattg 1820581 ttttaaccgt tgtctgtatc ggctttctcg ccggaagaga caaatcctca cgtacttctg 1820641 tggaagaatg gtctgtcggc ggcagacgct tcggcggtct tctcgtctgg tttttagtag 1820701 gcgctgacct ttatacggcc tatactttct tagggttgac cagtactgct tttacaggcg 1820761 gaagtgttgc atttttcgcc attccttatt ctgtgttggc ctactttatc gcctacttct 1820821 tcttgccaaa actttggaaa gttgcgaaaa ttcataaatt aacaacactc gcggattatg 1820881 cccgggaacg ttttaacagt aagcttttgg caagcctcgt tgccatcgtt ggggtactca 1820941 tgcttattcc gtacatatgc cttcagctga gcggcattca agacacgctt caggttgccg 1821001 gcactggcta tattaacgta aaattcgttg tgatcatttc atttattctt gttgctcttt 1821061 acacattctt cagcgggatt aaagggccca catatacagc catcattaag gacattttag 1821121 tatgggtcat tatgctgttt atggtggtgt ccctccctct cattcatttt aacggctgga 1821181 cgccaatgat tgacacgtta gtgaaggaag cgccgcaaat gctgacgata ccgtcagaag 1821241 ggccaaaagg cattccttgg tttatcacag catctattgt ttccgctctg gcacttttta 1821301 tgtgggcaca tgccgctaca ggtgttttca cggcgaaaag cgctgatgca gtaagaaaaa 1821361 acagcatgtt tttgccgctt tataatatcg tgttaatttt ggttattttt cttggcttta 1821421 tcgcctttct tgttctgccg gaagatacaa atccaaggct ggcgctgctg catttgattc 1821481 aaacatctta cggcggcgtg gcacaaggct ttgcatatgc cactatcgct cttgcttcat 1821541 taataccttg ttccattatg gcaatcggcg catcgaattt attcgccaac aacctatacc 1821601 gggatttgat tcatccgaat gtgtcgcaaa gcaagctgac tcttgtcaca cgttcaatgg 1821661 tgtttgttgt catcggtctt gcgctgctgt ttggaatgct gttcccgact gccttagtga 1821721 cacttcagct attaggtgta tccggtatgg tgcaaatctt ccctgcgatt gctgtcagcc 1821781 tgttctggaa aaaccaaacg aaagaagcaa cggttatcgg attattagcc ggcctagcgg 1821841 taacgtttat tgtgtatatc actcaatccg cacatggcat ttatgaagga ttctggggat 1821901 tggccgccaa catgatcgct gtggtcatcc tgaatccgct gttcgttaaa aacgcgggat 1821961 ccaatcctgt cattgaaggt ttatttggca aaaaacaaga cgctaatcca aatcaaaagg 1822021 gcgcataaaa aaaccatacg cggcagccgc gtatggtttt ttttacattt cttttttcag 1822081 tgtttcaatt gccttttcca tttgcgtatc attatcagac agcttctttt gaagttctat 1822141 cattaatttc gttgttgtat cgccagtcag tatgcctgtt tcattcagct tctctttttt 1822201 ctggaactgt ttgacgacag atacaaaatc ctggtcatac atactgttaa cctttacctt 1822261 gtaaccaagt gctttgagca ttttctgagc cactttgacg tttgtgcctg tatcacctga 1822321 tttgtacgtt ttatctgcgt ccaaatacgg cagcttcgcg taatcaggca gctctgcttt 1822381 cacttgaggc ttgatgcctt ttttgtgaat ccattcgcca tcagcagtca gccatttggc 1822441 aactgtcagt ttgacggtag agccatcatc atattctttt gccgtttgta ctgtaccttt 1822501 gccgaatgtc gtctcgccga ttaacggtac gtttgacgat tcatgaaggg cagcggccat 1822561 aatttcggct gcgcttgctg taccgtcatt tactaaaacg acggtcggct tggtcacttt 1822621 ccgttctttt tcggccttca tgacttcttt tgaaccgttt ttgtattcaa cctgcatgat 1822681 gtttttccct ttatcaatga acaggttgct catcgtaatc gcctgttcca ttaagccgcc 1822741 cgggttgcct ctcaagtcta aaatatagcc tttggcgcct tttttctcta aactgtcaat 1822801 cgcatctgtc agctctttag ctgttgtttc agagaaagaa gtgatttgaa tttctccgat 1822861 gttgttgtct ttcatctctg aatagacagt ctctacagga atggtatcgc gcttaatgga 1822921 aagatcgata ttccccactc ccgctctgtt cagttcaagc ttcacctttg tgcccttttt 1822981 gcctcggatt aaagcgacgg cttcatttac attcatgcct tttacgcttt ttccatttac 1823041 cttaatgatt tggtccctcg gtttgatacc ggctttttca gcaggtgaac ctttaattgg 1823101 ggatacaata aggatttctc cgtctttctc ctctacttgg gctccgattc cttcaaaaga 1823161 tgctgaaatc gtctcgtcga atgatttcgc ttgctcttga tccatatatg tagaatacgg 1823221 atcatccagt gattgaatca ttcctttaat tgctccgtct actaatttgt catcatctgt 1823281 tttttggtaa taatcacttt tgatttgctc atacgcttta tttaatttgt cgaacttgct 1823341 gtctcctgtg cttgctgatt tttggcccag gatactggaa ttgcccgtaa taaataaagt 1823401 aagcgccgaa gcgacaactg cagtgatcag cacaataaaa aacagtttta attgccgttt 1823461 caattaaaca ccaccttttt cttcttacat tattatcatg gacgaattct tattcgtcaa 1823521 ctcggagcag aaatgaaaga gaaacgccct tcttttgctt ttcataaacc tatgtcttta 1823581 tacgacatat gataaggaaa aaggaggatt cgatattgag ccgatattta gaaatgctgt 1823641 ccttattcgg tgtcgcaggg gcgcacccag gcgggctggc tttttcaaaa gcggtcttgc 1823701 aaaaggctgc accctctccg gatcagccga ttcttgatgc cggatgcgga acagggcaaa 1823761 cggcggctta tttaggacat ttgctgtatc ctgtaacagt cgttgataaa gatcctatta 1823821 tgcttgagaa agcgaaaaaa agatttgcga atgaagggct tgccatccct gcatatcagg 1823881 cggagctgga acatctcccg ttttcttctg agtccttttc ctgcgtcctg tcagaatcgg 1823941 tcctcagttt ttcacgcctg acatcctctc ttcaagaaat ttcaagagtt ttaaaaccca 1824001 gcgggatgct gattggtatc gaagctgctt taaaaaaacc aatgccccct gcagaaaaga 1824061 agcaaatgat ggatttttac ggatttactt gcttacatga agaaagcgaa tggcataaac 1824121 tcctaagatc ctatggcttt caaaaaacag aagcgatgtc acttcttccg gaagacatgg 1824181 aatttgaacc aaccacagaa atggatttat cgcaaacgat tgatcccatc tattacgata 1824241 cgcttcaaac acattatcag ctcatgcagt tatatagtga gtacatgggt cattgtattt 1824301 ttatcgcgta caagtaaaac ggcgtatcgc cccctgtttt cgtccaacct ttttttccta 1824361 tctatcatat gctgatagaa agtcaggata ggaggggaac aatattggag agatattatc 1824421 atctttgcaa aaaccatcaa ggtaaagtcg tcagaattac agagagaggc gggagagttc 1824481 acgtcggcag aattacccgt gtaacaagag acagagtttt tatagctccg gtcggcggag 1824541 ggccaagagg tttcggttac ggatattggg gcggttattg gggatatgga gcggcttacg 1824601 ggatttccct cggtttaatt gcaggagtgg ctctggctgg tttattcttc tggtaagcat 1824661 agaacaaatg ctagattcac cagacacaat gaagcccgct tatctagtgt aagcgggctt 1824721 ttcattttaa attttcttca ctttttcaaa gtactcttca agcgttaaat cattatcttg 1824781 gatgaccttt gcggcttttt tgcctacata gcgcagatgc catggctcat attcatattt 1824841 cgtgatatct tctttatttt tcggatagcg aataataaag ccatatttat aagcattgtc 1824901 ctgcacccat ttcccgtctg ccgtgcttcc gaacgcttca tttagctcaa agccattgct 1824961 ccggctcgaa atgtccatcg caaggcctgt ttgatgctcg ctttcacccg ggtaagcgac 1825021 cgcttccttt gccttccttt ccccttttag gcttacttca ttgtcaaaaa tgactttctg 1825081 tctgtcatac gaacggtacc ctgagacagc tgccagttca tagccttcct ttttggcagc 1825141 atcgaacatt gtttttaatg cgtcggccgc ttcttttctg atgtaacgtt tttgaatctt 1825201 ttcttcaaaa gaaaactcta catcaggtat gacaagatcg ctaggttcat agtttccggg 1825261 cagtgcatat tgtttattga caagcgcgag tatattttct ggattttgaa tggtttccag 1825321 accatcgact tttttaatat cattgaaata ctggctttcc aatgaaaact cactgttttg 1825381 agtgtttgat tttttgctgt cagctgtttt ttgttctgtt tgctttgttt ctgctgtggt 1825441 tttcgtatcc ttttgagcat ctccgttcga catgctgcag ccggctccga ctattgccgt 1825501 tacactcaga gcggcagcca gtgagaacca tttaccggac tttttcatat tacattacct 1825561 tccttttatc aatcgtttcc gcatgcataa agaagaggct gccggcaccc agcacgcctc 1825621 ttgatatatt ttattgtgat acggaatgta aagccacttc tatcatatca tgaaatgtcg 1825681 tttgacgctc ttccgctgtc gtttcttctc ctgttaatac gtgatcactc acggtgagaa 1825741 ttgacagggc ttttcttccg tgcttcgctg ctaatgtata caatgcagtt gtttccattt 1825801 caacgccaag cacaccgtat tttgcaagtt tttcaatttg cgaatcgtca ttgtagaact 1825861 ggtcagctgt aaatacgctt cctacagtca ccggcacacc tttatccttt gcggcatcat 1825921 aggcattttt taaaagctcg aaatctgcgc aaggcgcaaa atcaacgctt ccgaaagcaa 1825981 ctctgttcat ttgtgaatca gttgaggagg tcatcgccaa aatgacgtct cgcactttga 1826041 catctttacg aatagcgccg caggaaccga ctcttattag attttgcaca tcgtagcttt 1826101 gaattaattc attcacataa attgaaatag acggaactcc cattcccgtg ccttgtactg 1826161 agattttttt acctttatat gtacccgtaa atccatacat gcctctgact tcattgtagc 1826221 attctacatt ttcaagatac gtttctgcaa taaattttgc tctgagagga tctcccggca 1826281 aaagcacagt atccgcaatt tgtccttttt cagcacctat atgtacactc atctcatatc 1826341 ctcctgtaaa tctaaattat catccagccc gtccatttta caacgaatgt catgatgaaa 1826401 caaacttcag cattgattat aaaggaatat atcgaaaaaa gaaatgttcg aggatctgtt 1826461 aggcacttcc tcagaaaaac ggataatcgg ggtgttaatt tgaaaaccta accgcaggaa 1826521 ggaggggtgg gacatgggta aaaaacatcg taaccggatc accggccaaa aaaagaacaa 1826581 tcatatacct gaaaaagata tcattgcagc tgaagaagca cacgggaaag aatattccgc 1826641 tgccaaacgc aagccttaaa actgcagaaa actgcgggtt tccgcagttt tcttttcatt 1826701 atgtcgtttg tacaatcaga cgattgattt tcctccagcc ggcgggaagc agttgataat 1826761 atgttttccc ttttctgcct tcatcaatca ggatcacgtc ccctgtggcc atgaatcttg 1826821 catcataatc actcggaaca gtgtcgaata cattaaacaa agagaatgct cttttcagca 1826881 cgtcttgatg atcgctcccg ttcagttcag ttcgatagac ggctctgtag cccttttttt 1826941 cgccaaaccg gggtgtctga aatattgtca cgtcatagga acaagacttc tttttaaaca 1827001 cggataacat catcaagatc ccctcccttt tatttcttta acatattggc gtttttgctg 1827061 tgttttcctc tctctatttt tgtcgaaacc gcttaatctt ttcgtcaaaa ccttttacta 1827121 ggaaaaacag aagcaagccg aggctaaagc ctcctaacac gtctgtcaca aaatgaaccc 1827181 ccagatacac tctgcttatg ccgactaaaa cagcaattac accggctatg atatatacca 1827241 tttttttatg cttagacaaa aacgggagat gtttcactaa aaagtaagca ataacaggat 1827301 agacacaagc agcattcatg gaatggccgc tcggaaaact gaaggatgat tcatgaacca 1827361 gcggtgcaaa atcaggcctc actctttcga tccattcttt taagactttg tttaacagcc 1827421 gatctgtgcc gaatactaag agcatcaaca ggccgtccca tgtttttctg tagaaaaaca 1827481 tgcctgctcc aatgatgaca attagaggga gcagaaaaga agaagcacca agatgcgtga 1827541 tccccgtcat gacttcatta agccatggct gacggatcaa aacagctgcc ttgcttattg 1827601 cttcatctgc agattgaaca gcatttgtat gaatggccgc agctagaatt aaaaagaaaa 1827661 gaaacaaact aacgggcttg tacaatttta accacctcaa ttttcacaga agtcatagaa 1827721 catgaataat aaaaccggag ctgaccgctc cggttttaag cctcactcat cttcatccag 1827781 ctcttcatct atcatacatt tttctatcaa ataatcaaag gtaatatcag cgatttcaaa 1827841 cagctcatcc tcactcggta tgtagccccg tcttgcaagc tctctgtaaa aaaattcagc 1827901 gatttcttcc gtatcaatca caagatctat ttctttcatc tccgtaccgc ctcctttttt 1827961 atgttttatg aaaaaacagg ctgaattata cccggtgttc taaacaattc tttcagtcat 1828021 atattgaata aaaaacgagc catgggaggc tgacgctatg attgctaaaa tgatggaagc 1828081 actggacgga gaaagatttg atatcataat ggaaaaaacg ctcaaaggaa tgacgcgtgt 1828141 gatgatttgg ggctgtctgc catatttttt atatgtcttg atccgtatgt tcacaaatta 1828201 actgaaatgc tcttttaaac tttccaaaac aaacatcatc atgtctttat attcttcatc 1828261 ctgaaacatt tcgtacagaa ttttgtagtc attataaata tccagaagct catcaacaat 1828321 tgacacagca aggatgtgaa gggtatcttg atcttcatca ccgccttcaa actgaagaag 1828381 agcagacgat gcgatatctt cgccgatctc atggccagtt tctccgacat aatggacaaa 1828441 caacagctga tgcacaaact ggtccatttc atattttcta agcaccagcg tgagatcctc 1828501 ttcctccgtt tcaagccact ctccatcctt taaacgggtc agctcataaa tgatatcttc 1828561 ccagccatct tctaaatatc tccaaatttc tgttctatgg ccgataatgc gaaagagttc 1828621 ttttccataa tctttaacat aaacaacgtc cccaataagg aattcatact caatatcaag 1828681 cttctccatg tcgacaatga caccctcata atctttataa agctgaatag atgattcaaa 1828741 gtataaaact tcgttatgat tgacttcata aagatagtgt ttatcaattt ggtgtacttt 1828801 tgtgatggtg ccgactgttc catacataat gacgactacg atatccccta cttggaattt 1828861 cggtttattt tgcttcatgg tgtctccccc tcgccgcaac atttctcata cgctatcgta 1828921 tgccgggtga agccaattcg catgggcatg aaaaccaaag gaaatatcca attatggtat 1828981 gggtatggac ataaaaaaat ccgcagtgat ctgcggatga aacagctatt atctgccgtg 1829041 cacttcagac tcgtattgat cccaagcttc atcaaacgtc gccatcgtgt gaaggtaatc 1829101 agcattcagc tccaaatatg aactgatttc atgataatcg gttgatgttt ttggaaagct 1829161 gtgatcctca tacgcctgat tggcaaattc actgatgctg tccttcggct tagggtgtct 1829221 gtatttcaat aaatagtgat aaaaggattt catgggtttc ccctcctgat gtctgtcttt 1829281 tgttgttcta ttatacagtt caagtgtaaa attacaacaa aagaatactg aaacatgact 1829341 caggagaagt caaaatagtt gcgtttcaaa attctttctg tctccatgag ctgctgatat 1829401 gtcaggcttt caggcagttt ttttgtttga attaaaagca gctgatcctc aatctcttta 1829461 accgtgtttt cctcttgata ggtcataccg caggaagaac ataccatggc aggggtgtct 1829521 gtcagttcta tagccctcgt tccatcaggg agctcccagt acaccgtgtt cctgccgggc 1829581 accgcttcga gctcgccgca ccattcgcat gttttcatga agaatcccct ccgcattcag 1829641 tctctttctg ttttttctgc tgcgccaaaa atttcttttc tttgagctga tctcttttct 1829701 cacgccgatc ttttaatgtt tcatgctccg gatttgcgat gtatgcctct ctccttttga 1829761 ttctgtctac attttcaggt gtaaacgaaa cttctttgtc agcaaaaatg gcactcagcc 1829821 cgatcggctc ctttttgtca gcggtttcag ggaaaacgga ctcaaaatag gcgtctgcct 1829881 gattggggat ataattctct ggttccggat atgacgtaat cacaccttca aaatttctta 1829941 agatcacttt gtcaggactt tgtgacagga catagtttgg ctgcagggcg attttacctc 1830001 ctccgcctgg tgcgtcaacg acaaaggtag gaaccgcata gcctgaggta tgacctctca 1830061 gcccttcaat gatctccaaa cctttggaaa caggagctct gaaatgccct attccttctg 1830121 acagatcaca ttggtaaata taataaggac ggactctgat ttttaccaag tcatgcatga 1830181 gctttttcat aattggaacc gaatcattaa tacctgctaa tacgacagcc tgatttccga 1830241 ccggcactcc cgcgttcacc agcttttcac atgcctcaac ggattcttct gtcatttcga 1830301 tgcttgtgtt aaaatgggtg ttcagccaga ccggatgata ttttttcaat atctcgcaca 1830361 gatgatcggt aatgcgctgc ggaaagacga cgggagctct tgttccgatt ctgatgactt 1830421 ccagatgcgg aatgctgcgc agctctttta aaatatattc taaaatttgg tcgttgatga 1830481 gcagcccatc accgcctgaa attaaacaat cgcggatttc gggtgtttcc cggatataag 1830541 caattgcagc atcaagctgt tttttgggga cgcccattcc gatttgtccg gaaaagcgcc 1830601 ttcttgtgca gtagcggcag tacatggaac attgattcgt gacaagaaac agcacacggt 1830661 cgggatagcg gtgtgtcaga ccgggtaccg gtgaatcttc atcctcatga agcgggtctt 1830721 ccagatcgta ttttgttttg tgcatttctt cagaaagcgg cacagactgc atgcgtaccg 1830781 ggcatctcgg attgtcgggg tccattaaag aagcatagta aggtgtaata tttaagggga 1830841 tcgttttggt agaaattctg acgccttcct cttcatcctc ggtcagatta atgactttct 1830901 ttaaatcatc taacgttctt acagtgtgtg tcagctgcca aagccaatcg ttccatttct 1830961 cttccggaac gtccttccat aactcgatct ccttccaatg ccgtttcggt ttataccatt 1831021 tgtttttcaa acgaactcct cctcgcgcat attttgactt acagttgctt gcaccaaata 1831081 ttcatgtttt caaggccttc ggctataaag caattattga tcagccttcc gccatactga 1831141 taacctgaat ggtacaacac agcattcatc ccaaaagacg aagcacgggc gagagaaaac 1831201 acatgaacga tatcctctcc agccatttct ttttctaacg cctcgattaa aaagcttgtt 1831261 aacgaatggc cgcgatattc cggcagcaca gcgcaatcgg ttatttctgc atgcccaagc 1831321 tctggattga tttctgcgct tgctgcgctg atcaggcggt catgatcaag catgatataa 1831381 tacaccgtat ttgcattcat cgtcttttca atataagcgg ggtcaaatac cggggttggg 1831441 tacgtgcgga atactttttt atacagcatc gatagctggt acatgtcgtt tgtttctgct 1831501 tttctcatcg taaaaacggg tgtactgtcg ttgcgaagac ggggcgctgt gcgatatatg 1831561 gcttcgatga tctcctgttc ctctgtataa gaatctgttt gtctccggct ttctgaaagg 1831621 taacgtacca tgacacaagc cgaatggccg agataatagc cctttagata gccctccggc 1831681 gcaaataatt gtttggcaag gatcggctca tcatgctgct tcgcatagac aatgattttt 1831741 tctgcattct cttcttttgc cgctgccacg atatccggca gggccttctc aatggctccg 1831801 tcataacgaa ccactctgat tcgtttatta aagccgtcat ggtccaaaac tgctgtgaca 1831861 ccgctactct ttattgactt gagcatccgc atcctcccca tctgtatgaa ggccgcacca 1831921 atccatgaca aaaagtgcaa taattttagc agattctatc atggcttcaa cctcaatgta 1831981 ttcattggcc tgatgagccg tttttgtttc ccccggcccg aaaacgatca ctggtgtatc 1832041 tcctgcatgg tacaaaagcc ctccatccgt tccccacggg gaagcctcaa taatcggctc 1832101 tgtctgtttc attttttgat aggctgattg cagcacagaa attaaagggt gatcatcagg 1832161 taaatcattc ggcagccatt gagcgccaaa ccattcgact tgtacgggat ggcgtttaaa 1832221 ccattcgtca tggtattcta aatccttcag ccagttttcc aattcaagtt ttacagcttc 1832281 tggtttctca tggggagcaa ttccgcatct cccttctatg acgacacggt ctgcaactga 1832341 agatggccag gcaccgcctg agatggtgcc gatattcacc ggtaccggta ttgggatatt 1832401 gtcatacagc ggatctgaaa ttctcgcatt gcggactttc tccagctctt gtatcgctgt 1832461 gataacgtgc atgctttttt caatcgcgct taccccttca tagcgtgtgc ccccatgtgc 1832521 ggataatccc ttcacagtga tccgaaacca catcgaaccc tgctgcttaa taaatagttt 1832581 catattcgtc ggttcaggaa tcagcgcccc gtcagcacga tagcctctca tgatggcgga 1832641 aagtgtaccg gcgccgccgc actcttcatc tacaacactc tgaaacaata catctccctt 1832701 cagtttgaca tcgcaggcgt gcagggcttc taaagcaaaa agaagggctg tattgcctcc 1832761 cttcatatcc gttgagccgc ggccgtatat tttaccgttt tcttcgacag cttgatacgg 1832821 ttcatacttc caatccttta cgcttccttc aggcacaaca tcgatatggc cgttcaaaat 1832881 cagggacctg cctccgccgg ctcccgtttt tttagccacg atattcgggc tctcatgaaa 1832941 atcggatcgg ttagatttaa agtagggatg ctgttttaat tgctttatgc ttggctccca 1833001 tacatcaatg tccatatgaa attgccgcag cttttcaagc acaacagctt gggcgttaaa 1833061 ctctgacccc aatgtgcttt tttccccaat cagccttttg agaagacgaa tggctttggc 1833121 cgaatgctga tcaagccact cgattacttt tctttcaatg tcttgcatcc tcattccccc 1833181 tcttaagaaa aaggcatatc tattttgatt tcagcttctg tcagcctcgt cacctcatcg 1833241 attgtcgagc cattcatcag ctcttttaaa atgaagtgat ggctatcgac ctcaagaacc 1833301 gctttttcgg taataatcaa atctacacag cctgcagcag ttaatggcag cgtacatctt 1833361 tctgttaatt taggccttcc cttttgatct gtatgactca tgacgacaac cacttttttc 1833421 gctttttggg caagctccat cgccccgccc ataccaggca ccttttttcc cggaacaagc 1833481 caatttgcca aatctcctga ttggctcacc tgcagggcgc ctaaaatcgt aatgtcaatt 1833541 ttgccttttc tgatcatcgc aaaagacatg gttgtatcaa aataagaagc cccttttaca 1833601 gcgcggacag gatatcccgc ggcgttgcat aaatgcgcat cctcttctcc cttttcggga 1833661 ctttctccaa tgccaaggac accgttttcc gcttgaaaca tgacctgcat gtcaggcttc 1833721 aaaaagttcg gtaccaagga agggataccg ataccgagat tcacaatcat gccctgctta 1833781 atttcagtag cagcgcgttt tgcaatctgt tctctttctg ctactcccaa gcccatttcc 1833841 acttcactcc ctcgcttcgt acaaccccct caacaaaaac ccccggtgtg acaatcattt 1833901 cttcagaaat ctcccccatc ggaacgatac gctcagcttc ggcaaaggtt ctcctggcgg 1833961 ccattgccat aagcgggttc atattgcgcg cggttttgtc atacgttaga ttgccgaatt 1834021 catctgcaat gtaagcattg atgaaagcaa aatcagcagt cagcgcctct tcaatcaagt 1834081 atcgttttcc cgccactgtt acgatgtcct ttttttcgca aaccatttga ttatcaatgc 1834141 ccacgtcggt taaaataccg ccaagccccg ctccgccggc gcgaatccgt tccgcaagcg 1834201 ttccctgagg tgaaaattga acctctaacg tcccctctgt catctgtttt ccggctactg 1834261 gattggaacc gatatgcgag gcgatcaggg ttttgacccg ttgattaaca ataagcgggc 1834321 cgattccgat atccgggaaa ccggcgtcat tgcaaatcac agtcaaatcc gttacaccgc 1834381 tgtccaatat cgcttcaatc aatgaaggag gcgacccgac tcccccaaaa ccgccaaaca 1834441 tcagaaccga tccatcccga acatctgcaa ttgctgtgtc aatgctgatt gctttttgaa 1834501 atggcgccat ttaatgtcaa tcctttttta agtttttttc gaccgctgca actgtttctg 1834561 aaaaaataga gataagctct tccatttcac cgtctgaaat agtaaaagga ggagcaataa 1834621 tgacagcatc tccttctcca ctgtctattc cagctttgga aggataaaca atcagcccgc 1834681 gttttttcgc ctcgctgaca ataagctggg ttatcgcctg ctctggcgga aacactttct 1834741 tcgttttttg gtctgccaca aattcaatgc ctaatagcag tccttttccg cgcacctcac 1834801 ctataatgcc gctttgagat gccgcctcat caagcttctt cttcagcaca gcgccctttt 1834861 tttctgattg tttgatcaag ccgtgcttta acacatatcg caaaacttca agagcagctt 1834921 tggctgaata gggatgtgca ctatatgtgt gaccgctcat aatcacacct gacccttgtt 1834981 ttatggtttc aataatagaa tcagatacga cggcagcagc aataggtgca taccccgcac 1835041 cgagtccctt ccccagtaca gcaatatcag gtacggtatc ccaatgctct gtcgcgagca 1835101 tccttcctgt tctcccaagc cccgtcatca cttcatctgc aataaaaagc acatcgtgtg 1835161 tgcggcatac ctcacttaat ctctcataat atcccggagg cggagtaatc gctgctcctg 1835221 cagcaccaat aataggctca gccacaaagc cggcgatgaa ttggcttccg attcttttaa 1835281 tcatggtgtc cagttcatca gctgcagtct gaacaaagtc ttcttccgtc tcgtgattca 1835341 gccgataaat atgtggagct gagatagctg gataccgctc aatgagatgg gtgaaccggt 1835401 atctcctttc ataaaaacca gacaatgaaa gcgctcccaa agttattccg tggtaactgc 1835461 tccatcgaga caaaaagatg gatttttgtg tttgcttttt ttcctgccaa tactgaatgg 1835521 cgattttcat agctgtttct atcgcttctg atccgctgtt gacaaaaaaa gaccaattca 1835581 catctccggg cagctcctgt gccaagagag cggctaattg ctcggcgggc tcactcgtaa 1835641 actgtgagcg gtaagcaaaa gacacctgat caagctgttc tttcagcttc tcagtcacat 1835701 cacgaactcc gtggccgata ttacatgtca ccgcacctga cgagccgtcg agatattttt 1835761 ttccggtctg atcataaaca tatgaaccct tcgcataact gacaaccgga taggccgagc 1835821 taagctctgg cttaatcaaa taactgctca tgctcccacc tcaaaacccc ttttaccata 1835881 ttgtatgagt gtccaaatgg cggcatgacg ttccccgcaa aaactttttc acataaaaag 1835941 agccttccta ataaggaagg ctcttttgaa atttcagcat ctagcaaata aaagcggctc 1836001 caacaataat taataaaatg aacaagacaa caattaacac aaatgtattt gtcccgcagc 1836061 caaatccgta accgtaccca gagtatccat acatgctgtt ttcatccttt cttatcacga 1836121 tatacgacat tttatgcggg ccaagtccca aatggtttgt gcaaacgcct atttcatgta 1836181 aggaaataat gaaatacagt atgcacccgc tcatattttt taaacgtcag cttttcgtaa 1836241 aactgagttg caccgtcagt gcttgcagcc actaagtagg ctgcttccat tcctagtgat 1836301 ttggcgatgg acagcatttc tttcactaag atactgccgt agcccttcct ttgaaactga 1836361 tctaaaattg ccacttcttc gattttagcc gttttctctt gatgatcgat aaacagctcg 1836421 ccgcacccaa tgggaacttt ctgtgcctgg tcgctgtaac aaacaacaag aatgattata 1836481 tctgcttcat agaaaggata ttttcttttt aatttttgtt cagcgattgc ttctccaata 1836541 taaatggaat cgtaaatttt cataatagaa gatccgtcgc taagactttt tgccgtcccc 1836601 catgcggtta aaggatgtcc catctgcccc ttccagtcac taagcttcat gtcatatagt 1836661 agctcatcct cgacgacaaa accgcttttt acaagtgact gcttcaaacc gagcggaaaa 1836721 acatgctgcg gcgacgcttt taaatggaga taattcgcat caagcagctt tggtacggag 1836781 ggtaaaaagt taagtaaccg ctccaatgga aacgtatcat ggagctgaac aaagttatga 1836841 gaaaaaattt gcggaagctg cggatctctg tatacgctgt aatgatcaaa cgatgccgat 1836901 tcagacgtta acaatatata ttgatgttcc gtttttgaat aatgtcctgt catgaacgtc 1836961 tcctttttat gacctatacc tttactctgt tgcaatattc aatttcttta taatctcatc 1837021 gtacaccgga taaaacggct ttccaattgg aaattgctga atatttcgga aagaagcgga 1837081 gattggcttc tgatgtaaaa aaaacttcct tgttacttgt tcactaatcg ggtgaaagac 1837141 gccgtttaga aacaaaaacg gctcgcgttc gatgaaaaac agacgtcggc caggcggatt 1837201 tttgatcaat tcagatcgtt tccacgtaat cggcggccct tccggaagcg tctccatctc 1837261 ttcttttcca attgtcacta tgtcttttct ttgaaattga taaaattgaa acgcatactg 1837321 gtccacaatt cgcctttttt ttccggcttc gatataaaat attgcaggat ggtcagcttc 1837381 ctttactaaa atataattcg gaatgtttaa aattttgcca atcctatatt ggaataaata 1837441 tgggtctgga acagcgacag tccgatttag atacaaaaaa ccccactttt ctccaacagg 1837501 atgccttaca ccctgatcaa aaaaatacac attttgatct gaacctttta caaaagagcc 1837561 gtcaatcaaa tcggcgggca gaaaccgata tgcattttga aatgaatctg gggttttata 1837621 ggttgtgtct aatacttcat ttatcggcag aaatggggta aagttgttga gtctcgccca 1837681 aaaaattgcg tcgccatgat tccaatgctt catatcatca tcccagtagc ctccaaattt 1837741 atggtgaatg agattaagta acgaacggcg atgcataact gagcaatgat caacttgaaa 1837801 agcggcctga tcaagcactg cattggcatt tctgtagaaa tgtgagattt cctctcccct 1837861 ttcgtttaca tgtacaactt tttgttttga atagaccgcc tgcgcttcag gcttatgtga 1837921 aaactcttgc accatacggc tcagccgctc aggatgataa acagtgtcgt cagtaagata 1837981 ggaaatgtaa tcgccgtctg caaatgggag cgcactgtta attaatgtgg cataacgggc 1838041 tgtttttaat cgatctgcag gatgcacgaa actgttatga tattgaatgc gccggtcatg 1838101 gagatacttg tgaatcaccg cagttgtttc tgcattcgaa tgatcatcca tgataaaaag 1838161 ctcccaaaga tcatgcgttt gctgtatcac gctttcgatc gctttttgca aataatcggg 1838221 tttgttgtaa cttgttaaaa taatagacac tttctctccc atctataccg cctcccgccg 1838281 tcaaacataa aaacggctcc gcagcaagca gagcctctgt catcatttaa aaagcacccc 1838341 agcttacaac acttgagagt gaaacatgag atctcgtgtt atttaacggg ttttggaaaa 1838401 taaccaaatc agtcagaact tcttttacga tgacattttg aagtgtatct ccgttgatca 1838461 aattgacttt tgaaaccggt acgcccagct cttttgcaaa aacaagctgg cgtctgaggt 1838521 cagatggatt tccttcagaa gacgattgac gtatcagcag aatcagcaaa agcaaaataa 1838581 aatgcagatc atcttggttt tcttctcgat ccacttgttt ctctaaatcc aaatcatccc 1838641 tctcccttat ccttatctct gtttcacaat atgtgcgact tcgatttatg gtataggcta 1838701 tgtccactcc attaaaaaat cagcattttc cttaaataga tgaaaaatag atcaggtacg 1838761 gcgttcgact cataccaaat aacagccgga agaatatgaa taacgtgagt tcactatcga 1838821 ataggaggtg tgtgtaatga gctctgaaaa tgcacagtta aaaaaggatt taattaaagc 1838881 cgttttaagc cctttatttc caactgcaac agaaggagga gaaaatatgg atagtaatct 1838941 taaagccttg cttgatgctg ccatcgatca aaaagtagat gaaagtgaaa cggttacggc 1839001 agaatctatt ttagaccctt ctcttccggc aagatggatt tttgccagaa ttacgccagg 1839061 cactacaatc agcattgtga ctgattcagg tgacatgatc ggaccggttg ttttcgttgc 1839121 tttcgatcag gttcacggga tcgtatttgt aacacaggaa agctccgtca ctccggcagg 1839181 ccaagctaca acattaattg atgtagacaa agtagaaagc gttacgttct tttcataaca 1839241 tccgatgaaa gtcttgtata tccagtcggg atacggagga atatacagtt attttgatcg 1839301 ctgggctgaa gaatgttttc agaacactca tacagagtat atgattgcag ataaacctga 1839361 agcagaatct ttgatgaaga tcgaagcgtt tcagccggat ttcacactta tgatggttgg 1839421 agaccgcgtt cctcacgact ggctgacctg gttaaagggt aaggatatcc ccgtgtatgt 1839481 ttggctgacc gaagacccat tttatatgga tatcagcctt caggtaatta agcttgctga 1839541 cgccatatta acgatagaac aaaatgcagc tctctactat caagagctcg gctaccagaa 1839601 cgtctattat gttccgatac cagttaacca tcggctgttt aaaaaaatgg gcaccgaaca 1839661 ttcctatcat tcaaatctgt taatcatcgg ctatccttac cctaatcggg ttcagcttat 1839721 gaaagaagcg gtccatctgc cattcacggt tcgggtaatc ggcaaggaat ggggaaaata 1839781 tctgcctaaa aaagtgctca aacagccgca tattgatgtc gtcagcacat gggttccacc 1839841 cgaacaggcc gttcattatt ataatggggc agacatcgta attaatgcgc atcgtcccta 1839901 tcattttgct ttcaaccaaa atactatgcg catcaaaaat gccagtttta ataaccgaac 1839961 gtttgatatc gctgcatgcg aagcatttca attaacagat ttacccgcgg cgcatccttt 1840021 ttcatccatt atttcttatc acggcatgaa cgactttaag gaaaaagccg ctttctatat 1840081 caaccaccct gaagaacggc aaaaagctgc agcagccaat tataaagaga ccgtacccgc 1840141 atttacgttt gatgagcttc ctgcaaaact aaaagcgatt catctggcgc tttcttgaaa 1840201 aatcgttcat tgctatgaac gattttttta ttcatagaaa aaagcagctg cacaagctgc 1840261 tttctattct agccgtcaga acggtctttc agcttcctcg gatttacctg tttatgaaga 1840321 tcaggcattt cgccgagatg ctgtgcaatt tgttcccacg atacaatttt gaaattttga 1840381 ttgacggctt gtccgttatc aatattttcg ccgtcctgcg ccacaaaaat cccgtacgga 1840441 tattttgggc caagtccgaa accgagaaca tcaataccat ccgtgtcact agtaccgtct 1840501 atcttctcgc catctgtaat ctcaaagttg gctacatagc gatttttccc ctgccgttca 1840561 tacattgcat agctgttatt tccttgactt gaagccatga gatatccttt gccatttggt 1840621 gcataataga ttgtcagtcc ttcaatatca gctgtcaaat gatctcctgt cgcacggtca 1840681 acaacctgcc cctttgaccc tccgccgggc tcagcgttaa atttccagat ggcctcatct 1840741 tcctctgcta tgtataggtt tccgtactca tcatccgcaa caaggccttc ggtctgagaa 1840801 ttcaacttaa attcacgcac ctttttccct gttacataac cctttccacc atcaacaatt 1840861 tcatactgct caaattcccc ttgtttgcct gtcactaatg cgtaaaatgc tcctgttttc 1840921 tggctgtgat acaagctgaa tccataaacc tcagaaatat tggtggaaat aggatggttc 1840981 ggatctgtaa tgcttttcaa ttttccttta tccccgtcta ttgcatatac ttcaattgta 1841041 ttttttcctt cggaccggtt ggatgcggca gcaatatcaa ttttttcgcc gttcaatgga 1841101 aaatcatagc gcagatcgac attattgagc ttgccaaact cataagaatg aagctgtttt 1841161 ccgtctaaat catacacaac gagccctgac ttcttatttg ttgtaatcaa cttgcttttt 1841221 tccgggtgtt tttcatgaac ccaaatggcc gggtcatctg ctgcatcatc gccagatgcg 1841281 accggatctg tctccgtgtg tgcagtcact ttgaaatgat gttcctcatt cacataatga 1841341 gccgacaccg aggttgctgt caggctaagc aataaacccg cggcagtgct tagcagcatt 1841401 gtttttggaa ccttcatttg gtaccctcct cttttatcac taacactact attgtaaaat 1841461 atatacaggt gattaccgtg aggaaaatga accttttttt atagggtttc tgactcataa 1841521 acaacttatt ccccaaagag gtggtgagat gactttgcca gatttacttt tgcggagcga 1841581 aataaaaata tgttgaatat ttagtacatt atttatttag ttttgttttt ccctagttac 1841641 gtccgttttt ccattttcta ttaaaaaaga acactttgtg acatgatcat tcccctaaat 1841701 tttgttttat tggttgcttt cattaattcg attacaaagt tgaacatatg atgcatggta 1841761 gagaaacgag agttggagga taagccatgc ctaaacagca aacagcagaa ctaaaaccat 1841821 ttttccataa caaaacagtt ttagtcactg gcggaacggg ttcaatcggg agtcaaattg 1841881 tcaaacgcct tttgatgctt acacctaaac aggtgattgt attcagcaaa gacgacagta 1841941 aacagtatgt catgagccaa aagtatgcgg aggataagcg gctattattt gtacttggag 1842001 atgtacgcga tcacagaagg gtgaatcagg tgatgaaagg cgtcgatatc gtctttcacg 1842061 cggctgcgct gaaacaggtt ccgacatgtg aggaccatcc atttgaagcg atccagacca 1842121 atctcatcgg cggacaaaat gtggtggaag ctgccctttc acaccgagtg cagcatgtca 1842181 ttaatatcag tacagataaa gctgtatctc ctgtgaacac aatgggtgcc accaagctgt 1842241 tatctgaaaa gctgtttcat caagcaaacc gccacgtcca aaacaaagga accttgtttt 1842301 gttcggtccg ctttggaaat gttctcggtt ccagaggttc ggtcatcccc atattatttg 1842361 aacagatgat ggagggtgaa cctctgacca tcacagacaa aaacatgacc agatttttca 1842421 tgtcaataga cgatgcagct acattgacat tacaatcggc tgctattaca aaaggcggag 1842481 aaacctttat tttcaaaatg gaatcactga aacttgaaga actgattcat gggtttgaag 1842541 aatatgcatc gcagcacggg ctcccgcggc cggctgcagt agaagtgggc aagcgtccag 1842601 gtgaaaagct tcacgaagaa ttaacatctc cacatgaaat tgaatcactg tatgaatggg 1842661 gcaaccttta tgcgatcctt ccagagccgg aaaaacatcc tgactttcgc aaagtcaatc 1842721 tgcctgggta tcaatcagat caagccccgc tcattacgaa agaaagaatt gctcagatta 1842781 ttgaagaatt gcatcaagag aaaaaggcat aaaaacaagc ctgtctatcc attaggcagg 1842841 cctgttttta acagtttatt tattaaagag atgcagatag ctttcgtatc cttcttcttt 1842901 tagcttatgc ttcggaacaa accgcagcgc tgctgaattt atgcagtaac gaagtccgtt 1842961 tggccccggt ccgtcattaa atacgtggcc aagatgagaa tcagcagttc ggcttcttac 1843021 ttctgtgcga atcatgccgt ggctcgtgtc cagtttttct tccacttctt cttcaatcgg 1843081 ctttgtaaag cttggccagc cgcattggga atcaaattta tctttggatg taaacaatgg 1843141 cttgcctgac acaatgtcta catacaaccc ttcttcctta tgatcccaat attcattttg 1843201 aaatggcggc tccgtgccgt tattttgcgt tacttcatat tgcatgcgat ttaatgactt 1843261 tattttttct tctttattgt acgccattta tttagccccc caatgctcgc tgataaatcc 1843321 cgctcgtccg gaacctgtcc ggtagcgctg ataatgtgct ggattctttt tataaaaatg 1843381 ctgatggtag ccttccgctt catagaaagg ttcagctttt aaaatgtccg ttacaatcgg 1843441 atctttaaag atgccgcttt ccgccagacg ttgcttggaa gcttccgcaa gctccttttg 1843501 tttatcatta tgataaaaaa tggctgcgcg ataggaactg ccgcgatcag caaattgccc 1843561 tccggcatct gtcggatcga tttgctgcca aaataattca agcagttttt cataagggaa 1843621 tacatcagga tgaaacgtga tttgaacggc ttcacgatgt cccgtcgttt cactgcacac 1843681 ctcttcgtac gtagggtttt cagtatggcc gcctgtatac ccggacacca ctttttcaat 1843741 tcccggctgt tcgtcaaaag gtttaaccat acaccaaaaa cagcctcctg caaatgtggc 1843801 gatttctttt ttttcagaca tactggtgcc tcctttgtta atacgtggta ttattatatt 1843861 atagcatgta aaaatagaat gaaaatgatt ctgcttttca ataaaatcta taggttttaa 1843921 gcaatatgct tatgtaatgg aggttcacaa atttgaaagt aagaacacag atgatgtacg 1843981 atatggaaac tttactccgt aaagtcttta aacaaatacg caatgaaatc aatgaaattt 1844041 tagataaaga gctgtcgcgg aatgaattca ccattcttcg aatccttagt gaacaagggc 1844101 ctaaaaaagt cactgaattt gcgcctattt tagaggtatc ggcaagccac attacggctg 1844161 tgaccgatgc gctggtagaa aaggaatgga ttacgagaat cagatcgaag gaagacagac 1844221 gcatcatccg cattcatatc actgaagcgg gcgaaaaagt ccttcagcac tttaacgaga 1844281 aaaaaacgga atatttcttt aaacgctttg actgctacac tgatgctgaa cttgccacgt 1844341 taatcgagct cttcagcaaa cttgataaaa aacggtgaaa aaaagcacat accgatatat 1844401 aggtatgtgc ttttcgcagt gcttcactta tttttcagta aacagcttca ttgctttcca 1844461 gcggccatat ctataataca aaaatgccgc gcagctgcta aataaaaaac tcattccgat 1844521 tccaagcccg attccttttt gtccaagcca agctgaaaat agagctgtga aaggatacct 1844581 caacacccaa aacgagatca aatttaatac cagaacctgc agcatcgctc ccgcggccct 1844641 gacgattccg ttcagcacaa aattaacccc aataaaaggg tagaaaaacg cgatccactt 1844701 caaatattgt tcaccaaatg cgaccgcatc aggctcactg ataaataacc ttatgaggta 1844761 tttaccaaat acccaaatca taaccgcaat caccagcatg caggaaataa cagctatcac 1844821 acctagcctt gcaattgttc ccactctttt ttcgtttccg attccaatat tttgccctgc 1844881 catactattg acggccgtac cggcagccat tgctggaagc gtgatgatgc tatcaagccg 1844941 ctgcaccgcg ccaaagcctg ataccacgtg atccccgtat gagttaacaa cactcataat 1845001 cgccatcata ccgcctgtaa tcaccatcat ctgcagacct gccggaatcc cgagtttcaa 1845061 aatcagcgcg gactcttccc acttgggcat tctcggaatc gagaatggca caagcttgtg 1845121 tttgatgaca taaaacaacc catacaaaaa cgcaatgccc tgtgacaaaa tcgttgaata 1845181 agccgctccc gctattccca tgcggaacac agaaataaag agcggcgcaa gcactgtatt 1845241 cagtacaaca gcaaacgcaa taaaccggag aggtgtcttg ctgtcgccca gcgcacgaag 1845301 cacagtactg ataaagttat aaccaaacaa aaataaaatg ccgataaatt gaatctgtaa 1845361 atacgtctca gcaagcggta tcattgactc cggcgttttt agaagacgca gcaaaagctc 1845421 tgagagaaaa aaaccggccg cgccgaatcc gatgcttagg cctgttaata aaacaacaaa 1845481 agcgttaata tacgacgcca ttccttttat atcatctttt cctttttgct gagataaaat 1845541 ggttaacgtc gcattgttaa ggcccaaaat aaaagacagc acggtcaaaa caatcgtgct 1845601 tgataccgcg gctgccccaa gggcctttgc ccccagtaaa ttgccgatcc acaagctgtc 1845661 tataaattga aaggaaacct gcaatgcgtt tccgagcata ataggcattg aaaacagtac 1845721 aagctgtttc agcacgttcc cctgtgtaaa atcgtatgct ttcatctttt ctccttgtgt 1845781 tctcaaattt tcttcggacc acacgaaaaa agagacgttg tttcatgtct cttttttcat 1845841 gacttatcgg ttttttttcg gtctcgcata ccgaatgtaa acaccatcac acttaggaac 1845901 aaggcacaat aggaaacatt caaatacatt tgatccatat cttcagcagc cagatgatga 1845961 taagcaagcc agccgaagta cagggaaaat gtaaaggata ataaactgaa atactggtaa 1846021 atccgtttca ttttcagtca cctctattgt ttaggatggt aataggaaaa ctcaatttca 1846081 tctttttcta aatttatctt atccgctttg acatacattc cattcgttaa aggcatttct 1846141 gacaaacgca cttcaatgct tttatctccg gggtgaacat ggacaaatga cggcaattca 1846201 taaaagctgt ccatataatt taacacaaag ctaattggta tactcaattt ccctaacgaa 1846261 aatttcgtga cattcagctc tacatcaccg ttttttttca cggtcggctc aaaagcgata 1846321 aacgcatcaa tagacgtgga aaatgccttg attttccctg cgacatgaac atcatcatca 1846381 atctctactt tataatcaag cttgtttgat gctttgtcgt ttaaatatga gttaacaaac 1846441 gcagctaatg attcttttgt gcttgtcact tgaaatccat actcgctctc agatgcatct 1846501 ttcacctgag cctgttcccc cggaagcaaa acaagtgcca caaacccggc ggcgaggata 1846561 aaattgattg caagcaatat aaaaaacagt cgcttccact tattcatgct gtcaccctac 1846621 tctttcggta atccttcttt tttaatggct tgatagacgc gctttgcgat aagagaataa 1846681 cccgtaccat taggatgaaa atcatcttcc tcagaaattc ggctgctgtc acttttttga 1846741 ttaaacaaat cttcgatatg gacgattttt gcatgtttat cttttttcag ctctttttca 1846801 gcaatatggt tccaatccgt gacgacacca tttatttcat ttagttctga taatgtaaac 1846861 gtaaacggat tgtacatgct gacataaatc agctcagcgt gatcattcag ctcgcgaatt 1846921 tcagaaatga ttttttcaaa gcgcttttcg tacggttttt ccgcttcctg aaacggttca 1846981 acggttaatt gcagaaagtt ttggcgaagg attttcatca aatcattacc gccaattgta 1847041 aaaaagacat aatctgcgtc ctttatgcct ttttgaacct ttttatcttt tagtttttct 1847101 aataaatcat ccgaacggtt cccttttaca gcataatttt tcacgtcgac cgttttgact 1847161 tgtttatctg accggataga atccgccacc ttgccgacat atccctttcc gtcgggatct 1847221 ccgactcctt ctgtcagcga atctccgaca gccgctatga caatgtgttc ttttgttttc 1847281 gtttcatggg ctttttgttt tccctcagat gatgtacgta tgctcgtaca cgcagtaaga 1847341 agcaaaatca aactggccat gattgaaaaa atgcgcagct tcaatcttgt tgctccttcc 1847401 cattctacta gtggaaagtg tatcatgttt tagaagattt gcaaatgcct agtctcttag 1847461 cttacttgag tgtactggct gacttcacat cggaaatgat atcatcgtac ggtgtattct 1847521 ccactccatt gtaatctttc agcaccttac cgtccggacc taccaaataa aaagaagatt 1847581 gatgaatcac ttggtcctct ccctccggct tctttacgat cgctttaaag ctcttaagtg 1847641 cgaactcctc aatctcactc tggctgtatc ccgtgagaaa atcccagtta tcaaaagata 1847701 atggataatt tgcggcaaat ttcttcagct gtttcggctt atcgttttct ggatcaacac 1847761 taaatgatat gatgcggaca tctatatttt cggctttcag ttttttttgc agatcggtca 1847821 tatgagcggt cattggcgga catatagttt cacaattggt aaaaataaaa tccgccagcc 1847881 atacttctcc ttttaaactc tctaaagaaa cgttcttgcc gtcttggttt tgaaatgtaa 1847941 aaggctccac ctcgtaattg agcggatctt taatctgctg tcctccgcat gcacacaaaa 1848001 acagaaaaat cagcccagcc gttaacccct tgataacctt catgacatcc atcctttcca 1848061 gccagcataa aaacgctttc taaaaccgtc cttactgtcc catgtttgta ttcgatactg 1848121 agcaaaaaaa atcctgcatg cctccccatt aacgattaca aaggagggca tgcaggtaaa 1848181 aaacggcatg ttacgcgttg tgctttaaca cctcttgatg aaatacagcc tgataatctg 1848241 cccacttcat ccgccgcttc atataatgtc ggaaagaata cacttttgcc ctgctgtttg 1848301 atgaaaacac ttcttttaag tagaattgca aatggtgatg taacataaag aaatagtgct 1848361 catcttcctt taatacaggt atttctgtca ctttcacctg aatcccgtca ccgcgtttga 1848421 actctaggct tttgagtaac aagctatcaa tcctcttttt tgtttttctt ctattatata 1848481 tgatgccagc cgggctgtct gtcattttgc gcggttgtgt aaaaaaatta gattagcaaa 1848541 tggaacaagt cctcatcctt gttcacctct acataatgaa acggtttttt gttcatccgt 1848601 tcaatcagcg gcccataatc ggctttgttc tgcagctcga tgccgacaag agcaggtcca 1848661 ttgcttttat tatttttctt cgtatattca aaccttgtaa tgtcatcatt cggcccgagg 1848721 acttcgtcaa gaaattcgcg gagcgccccc gctctttgtg gaaaattgac gataaaataa 1848781 tgctgaaggc cttcaaaaat caaggaacgc tccttcattt cctgcattct tccgatatcg 1848841 ttattgcccc cgcttaccac acacaccacg tttttccctt taatttgatc cttgtacaaa 1848901 tcaagcgctg cgacagaaag agctccagcc ggttcagcaa caaccgcaca ttcgttatat 1848961 aattcaagaa tggatgtaca tacttttcct tcaggcacaa ggagaatgtc atcaacgaca 1849021 gtttccagcg tccggaaggt ttcctcgcca atttttttaa cagccgcccc atctacaaac 1849081 ttatcaattt tatcaagtgt gacgacatgc ccagctttgt ttgattcaaa gtaggatgcc 1849141 gctcccgccg gctcaacagc aattaccttt gtatcaggag acacgttttt caaatatgta 1849201 cctaccccag agagaaggcc gccgcctccg acacttgcaa aaagaaaatg cggttctgta 1849261 tcaatgtcgt ttaaaatctc gactgcgagc gttccctgtc cggccatcac atccggatca 1849321 tcgaacggat ggataaacgt ccgagattcc gcctcacagc attcagcagc gcttttatac 1849381 gcgtcgtcaa acgtatcgcc tgtcaaaata atatcgataa atccttttcc gaatagttca 1849441 acttgagata ctttttgtct cggtgtagta gacggcataa aaattttccc gtgaatgcca 1849501 agatgtttac acgaaaatgc cacaccttga gcgtggtttc cggcacttgc acacacaact 1849561 ccgttctctg tctgctcgct ggaaagctgt ttcattttat gataagcccc tctgagctta 1849621 aaagatctga caacttgcaa gtcttcgcgt tttaaataga tattgcattc atatctctca 1849681 gaaagtctgt cattcctctg caaaggtgtg tgaatgacaa cgtcctttac gttttggtga 1849741 gccttcaaaa tgtctttcac ttggatgaga gagttttctt taagcaacgg tttcatgtac 1849801 agattccttt cttgttttaa atccctattt aatatgccat tataacatga atattcaaaa 1849861 aataagacaa ttatttttat ttaataatta aaaaaataca gactatgtcc accacatctt 1849921 gtggtaactt ctgttcaacc attatcctgc agagccaaga aaaaagatga tcgtaaaata 1849981 aagggtgttt tcaaccaaaa ggcatgatat aatgaaacca attagaacca aaaggagcca 1850041 attgatgaat agtgcaccaa aactcaatac atttcaacat ctaatcggag aacatcaaac 1850101 ttttctggaa gcgaagcgaa tcgccaagca gttctcgtta tcggagcttc ctgtcttaat 1850161 aacaggaaaa atcggaacag gcaaaaatca cttcgcacat gccatacact tggaatcttc 1850221 gagaagcaat gaaccgttta taagcgtcaa ttgcagcacc cattcggaag aaacccttat 1850281 tcatgagctt tttggcccta acggaaacac aggtgttttt caaaaagcgg tacgaggaac 1850341 cctttttctt gatgatgtat ggcgcatgcc tgcttctgta caagctcagc tgttaaaagc 1850401 gcttgattca gacacggaga aaccgcgaat gatctgtgct tctgcagacc gatccgtgga 1850461 acatacattc aggcaagact tattctacag actgaacatt ttaacgctca cactgcccga 1850521 attatcggaa cgaaaaagcg atattccgct tttgacacag cattttctct caaattctgg 1850581 tcagcaattg ttaatcgatc cctccgtttt tcccgtgctt gagaagcatg catttgaagg 1850641 caatgtcagg gaattaaaaa acgctgcaga ttatatggcg gcagtatcaa gcgggggaac 1850701 gattcagcca tatgacctgc cgccgtatat tagaggcacg atagacggaa aaacgtcgaa 1850761 gaaaaaagcg aaactgctta ctttaatgga aaaagctgag tttttgttta ttttggaaac 1850821 aataaaagta ttgaacgaaa aaggagaacc tgccagcaga cggatcattt ctgaacacag 1850881 caaaaatacc caaacctcgt taactcctca gcaggtcaga agccgtctcg actatttgga 1850941 gaaaaaagat tatgtcacca aaagccgcgg acgcgcaggc acaaaaatta cctttgaggg 1851001 cttgagcttt atagagacgt taaaaaatca aatgatctag cgatcgaaag gagaatgtac 1851061 ttgtttacaa tcaaagaaga gatcgccaat gcgattacac acggcatcgg tgtcctctta 1851121 tccatcccag cattagtgtt tctaatcata tttgcggcta attacgggtc tgcatgggac 1851181 attgtcagct ttacaatatt cggtgtctct atgctgctgt tatatttgag ctccaccctg 1851241 cttcacagca tcacacataa aaaaacgaag gacattttgg agattattga tcatagcgca 1851301 atttacgtac tcatcgccgg aacctacacg ccttttttgc ttgggccgct gaaaggcaca 1851361 ctcggcttta ccctgttggt tatcgtatgg tcacttgccc taggcggaat cgtttttaaa 1851421 attttctttg tgaaacggtt tatcctattg tcaaccttcg tgtatttagt catggggtgg 1851481 ctgatgatta ttgcagttaa acctttatat gcttcactga gcggagcggg attcagcctc 1851541 ctttttctcg gcggcatttt atactctgtc ggaaccatct tttacatttg gaaaaagatc 1851601 cccttccatc acgccatttg gcacagcttt gtattgggcg ggagcgctgc catgtttttc 1851661 tgcgtgctct tctattgtgt aaaggtgcct ttcctttcgt aacagtaaca gaaaagcgca 1851721 gtcttcacga ctgcgctttt ttatgcacgt aattgttttt cattggcagg tatataagct 1851781 tttgaaaagg acaattcaat gtctgccggt tttaagcgtt taaaaaacga gccattttgc 1851841 atgttatctg ttcctttcgt ttccaccatc accaacggaa gatgatagcg ggccgcaagt 1851901 tctacaggat caatagaacc atctagtgaa agaatcaggc tttgtccctt ttccagctgt 1851961 tttgtcacat cttcatatac cttttctgaa tccccgtctg aaatcacatc catccgatcc 1852021 agccattgcc cgataaaagg caagcggaac acttttgggt tagcgataaa gccggccggt 1852081 tcctcaatat atccagcaat taaggccagt tcagccaaac gcaaacgggg atgcacatac 1852141 aaaacaggac cgtgtggtat tggctctggc tgatggatcg tcacaactga accggagatg 1852201 ccgatacagc cttctaaaaa cgcctttggc tgttcgtaca caagagccat ctgttttttg 1852261 tatgacagac ggggatcgag cattgtttga ttaaataatt gtttcatatt ttttaacagc 1852321 atatacacaa tataaaccac tagaaggctg tagcgaacca attaaaatcc tcccgcttta 1852381 gaagaattct ttttttcata cattagaaat tcgtaatcat acgggttttt ttcgtctttg 1852441 gtcccctgct cagaagaaac cagcttccaa ttggattcat caaattcagg aaagtgacgg 1852501 tcaccctcaa actcgtgatg aattttcgtc atatacagtc tgtccgcata agggaacagg 1852561 tccgtataga gctgagcccc tccgatcaca aagcattctt cagggcctga acaaatgtcc 1852621 agtacatcct ttaatgaact gacaaccgtg catccctgaa attctgaatc cggcgctgag 1852681 gtaacgacaa tatttttccg atttggaagc ggacgtccga tcgattcaaa tgttttccgg 1852741 cccataatga ttgaatggcc cgatgttatt ttcttaaagt atgcaagatc attgggcaaa 1852801 tgccacggca aatcattgtc tttgccgata agcctgttgg catccatcgc aaaaatgaat 1852861 gaaatcatac gctgaccgcc ccttttatat gaggatgcgg atcataatcc tcgatgataa 1852921 agtcctcaaa tgcaaagtta aaaatagaat caacctttct ggcgaaacga agctgcggaa 1852981 gcggtctaac atctctttcc agctgcaaat tgacttgttc aatatgattt tggtaaatat 1853041 gaacatcacc aaacgtatgg atgaactcgc ccggttcaag cccagtcaca tgagcaatga 1853101 tcatggttag gagggcataa gatgcaatat taaacggcac acctaagaaa acatcggcag 1853161 agcgctgata cagctgacag gacagcttgc cgtcagacac atagaattgg aacaggcaat 1853221 ggcacggcgg caacgccatt ttatcaattt caccaacatt ccaggcgctg acgattaagc 1853281 gtctggagtt cggatttgtt ttaatatctt caataagacg ggaaatttga tcaatggttt 1853341 ctccatcagc tccccgccaa gaacgccatt gggagccata tacaggtcca agttcaccgt 1853401 tttcatcagc ccactcattc cagattcgca ctccgttttc ctgcagatag cgtacattcg 1853461 tatctccttt taagaaccac agcagttcat gcgcaattga tttaaagtgg agttttttag 1853521 tggtgagcat cggaaagcct tcccgtaaat taaatctcat ttgatatccg aaagtgctga 1853581 ttgttccggt cccagtccgg tctccctttt tctcaccatg ctctaaaaca tgtctgcaga 1853641 aatccttata ctgtttcatt tttttcatcc tttaaaagta gtcttctagt agtgtaacac 1853701 aataaaaaat catttctgaa cccagaaatg atttttttat agtcagctga cgacaggctt 1853761 ttcatcctgt tctttttctt catcttgcag atcctgatgc gtatgtgcaa ttctgctcgc 1853821 cgctgctgca gcaagagctg ccacaatatc atccaaaaag gtgtgaatac cgtctggact 1853881 ttcatcaagt tccttaataa ttccaatctt ctctttatcc aaataaccga aattggtcaa 1853941 accgatcgac ccgtacacat taacgattga aagcgggata atttcatcta tgccgtaaag 1854001 cggttcatcc gtttcaacaa ggtgctgcag cggttcgggg agaagtttct gttctgcaag 1854061 ctgatcgagt gcaaggcctg tcaaaacagc atgaataatt tcacgtttgt tcaggacttt 1854121 ttctacattc tccatgcaaa cactgagcgg cagatttgga ttgtattttt cctgaagttt 1854181 ttgaacaatc cgtgcaatat cttctatcat aacgccccgt ttgttcagca tatcctttgt 1854241 tatatcgacc atttcattca ttgtgtactt tttcatgtct aatggcatct cctttaggca 1854301 ctcatccagt tgggaggcgt gttgcggtcc cagtaaatgc tcccaagctc atgatgtgat 1854361 tgaaatccat cttctgctgt atgataatga aaattaaacc agtagccgtc atgaggcggg 1854421 tggtctcttc gcacatggaa tctgagaaga tcttctccag ttgtccgatt gtaaacgttg 1854481 aaaatttttt ccgttttgcc cgctgaaggc atgcttgaga tcacaacatc ttggtacgcc 1854541 tcatcatctt gcaatgtcgc taaataatca ctaatcacat tttcgatttt tggcaggatc 1854601 tctttccgat agtcatcctc aatgacagga gcgattctgc tgccgaattt taaaaaggac 1854661 tgatcctcag cgctgtcaag gagctgttcc ttgtacgatt gaaaaagcag ttcaggatct 1854721 cgcctgtcat ccgactcatc atcgtacagg tcatgctcat cataaaaagc ggtgtaatca 1854781 ttctgctcaa gactgctcgg ctgtccggaa ggcttgtccg ccataagggc agccggagga 1854841 gatacgagcc cgaacgttac aatggtaaat aaaaccacaa gggtctttct catccacaat 1854901 ttcatgactg cttattcctc tctattttat tgtcatgttt ctcttatttt agcacatcca 1854961 aaacatgcaa gtcatgtact atatgaaact gatatgcaaa ttaggagatt cgttgctatg 1855021 cactttgtgt aaaaacgctt acaatatttc atgaaaggag gctttccgca tgattgacgc 1855081 tctgtttgcc acagtttcac tcttaacatt attatacttt gtcgtcatgg aggtcaccga 1855141 ttaacagaaa gcccgtgata tgaatcacgg gcttgtttga atgacgccat aatggaacag 1855201 tgctgttttt cttttcatga cgttaaaacc aaactgttca aaccgcgggc ttttccagtg 1855261 gtcttttagc acaacgcttt ttctggcgac tcgtaccgct tcattgatac atccttcgtg 1855321 caaaacggaa tcctctgcca aatcacgtaa aggcgcgatg ccgtcagagg tttctacagg 1855381 ttcatgaaac attggatcga aataaaccac atcaacagag ttgtcaggga gctgcttgat 1855441 gtgttcaaag caatcaccat tcttcacctg gattcttctc atcgcagctt gaagctcttc 1855501 tatacccgtt tcccatgaat gcagccccgt cctcactaaa acagacacaa gatggttttt 1855561 ttcaatccca acaacagaac ccgtttcgcc tactgccata cttgcgataa tggcatctga 1855621 ccccaacccg agtgtgcaat ctaaaaacgt atccccttca gataagccgg cagcccgaag 1855681 cataggttct ttctccccct gtaagaagcg tttggctctg aacatcgctg tattcggatg 1855741 aaaaaagaat ttggcacctt gtttcgtata cagctcaaac cgctctttgc cgaccacaag 1855801 caaatcacgt tcagctgatt tcagcaggtg ctcaaccgtt tgtttattcc ggccgcagta 1855861 tggcatattt agctctttag aaagctgctt tgcagttttt atggtgtgtt cagacggtct 1855921 atagcttgtt gttatcatct tctgtactcc caaaaagaaa atgcccggag aacgggcatt 1855981 tagcagtgcg catcgaaggc agcagtcaga tttttcatga tttcttccat atcgtgtcct 1856041 tcaatttcat gacgcggaat aaaatgtacg acttctttgc ctttcaaaag agccattgat 1856101 ggtgaagaag gctcctggcc agtaaaatac tcacgcattt tcgcagtagc ttctttatct 1856161 tggcccgcaa atacagtcac cgtattgtca ggtgttttgt cattctggag gactgcctgt 1856221 gtagccgcag gacgcgcaag gcctgccgcg cagccgcata cagagttaac gactacaaga 1856281 gttgtgccct ctgccttttc cataaagttt tctacttctt ccgctgttgt taactcttca 1856341 aaacctgctc cagtcagctc gcggcgcatc ggtacgacaa gctggcgcat gtattcttca 1856401 taagccattg acataaaaaa agccccctct agtatccttc atctgaagta aaggatacta 1856461 tagagagggc cggatttcaa atgttcacgc cttaaaataa aagaaagtgt ccccagctat 1856521 ctagattttc ataataccgc cggtgttggc acttgtcaca agtttagaat aacgtgccag 1856581 gtagccggtt ttcactttcg gttcaaaacc tttccagttc gcttttcgtt tttcccactc 1856641 ttcttctggc acttgtacat ccaagatgcg tttttcaata tcaacgataa tatggtctcc 1856701 gttttcaaca aaggcaagcg gcccgccctc agcggcctca ggtgatacgt ggccgattga 1856761 gaggccacgg gaggctccgg aaaaacgtcc gtccgtaatc aatgccactt ttggcccgag 1856821 tcccattcca acgatttggg atgttggcgc cagcatttcc ggcatgccag gtccgccttt 1856881 tggcccttcg tatctgatga tgacaacgtc gccttctttt acttttcggt tgataatgcc 1856941 gtcaagcgcc tcgtcctgag aatcgaatac gacagccggc ccttcgtgtc ttgtaatccc 1857001 attctgtacg ccgcctgttt taatgatagc gccgtccgga gctagattac cgaataaaac 1857061 agcaaggcct cccttttcag tgaatggttg atccagcggg tgaatgacgt cataatcctt 1857121 tacttcatgt ccggcaatgg tttctccaag agtttttcct gtaacagtca gcgcatctaa 1857181 atgaagcgct ccttctttct tcgaaagctc attcagagcc gctgaaacgc cgcccgcttc 1857241 gtgaagatct tcaataaaca catccgatgc aggcgccagc ttagccaagt gcggcacgcg 1857301 ctcagcgact tcgttaatgc gttctaaaga gtattcaacg ccggcttcgt ttgcaagggc 1857361 aagggtatga agaacggtat ttgtagaacc tccgagcgcc atatcgagtg caaacgcgtt 1857421 atcaatcgct tttactgtaa caatatcacg cggtttgata tctttgcgaa tcgtttccat 1857481 taattgcgca gccgattttc tcacaaactc tttgcgttcc ggagatgttg ccagaatggt 1857541 tccattaccc ggcaaagcaa gaccaagtgc ttctgacaga cagttcattg agttcgccgt 1857601 aaacatgcct gagcaagacc cgcacgttgg gcatccgaac tgctctagtt cttgaagctc 1857661 gttttcgttg attttccctg cttggtaggc gcctacccct tcgaatactg aggaaaggga 1857721 gatttttcgc ccgtcacttg ttcttcctgc cgccatcggt ccgccgctga caaaaatcgt 1857781 cggaatgttg atgcgcattg ccgccataag cattcccggt gtgattttgt cgcagttcgg 1857841 aatacagacc attccgtcaa accagtgtgc ggatacaacc gtttccacag agtctgcgat 1857901 aatttcacgg cttggcagcg aatatctcat accgatatgc cccattgcga tgccatcatc 1857961 taccccaatg gtattaaatt caaacggaac gccccctgct tctctgattg cttcttttac 1858021 gattttccca aactcctgca agtgaacatg accgggaacg atatcaatgt atgaattaca 1858081 caccgcaata aacggcttgc cgaaatcctc ttcttttacc cctgctgcac gaagcaaact 1858141 gcggtgcgga gctctatcga ttccttgtgt gatcatatta ctgcgtaatt ctgccatggt 1858201 gatcctccta aattctttca attgtttgat tggattttat tttgacaatt ttcagtttat 1858261 ttatgggctg tttttgcaaa taagataaat acaggccgcc ctcaccttgt tttgttcttt 1858321 cgtgttttta tatttatata gctttctttc gatttgaacc ctccaactat taatattgtt 1858381 acttactata aatagttttc ggatattttt caacaatatt cgaaataatt tttataaaaa 1858441 gtgaattcac ataaaaaagg tgcatgatct gcaccttttt tatctttatt cgcctttttt 1858501 tctgctttcc gtcatttgtt tccaaacaga accttttgct tcttctccat gctcaatacg 1858561 ttcaagcgcc attttgactt gaaggctgac ctcaaattcg gggtcatctt cggcagcgcg 1858621 caaagcttca attgcacttt catcgccgac ttcgtacagg aacatggcgg cacgccagcg 1858681 aacaagcttg ctggagtcgc ttaatgactt gatcatagca ggaatggctt gaggatcgcc 1858741 gatatcagac aggcagtctc cggccgttct tctgactgat acagctttgt cctcaagtgc 1858801 tttatacaat agaggaagaa catcaggtgt ttcaatcatt cctaagtaca caacagcctg 1858861 tcttctgatg gacacctttg gatcatccaa tgccttctgt aaaaccggga tatcctcttc 1858921 tttcggatcc atctgttcca agtgtgcata acgctttttc cagtcctcat catccagcat 1858981 atcaagcgtt actttatacg ctttgcgctg tacagcttgt tttgcttcgc cctttccttg 1859041 agcggctgct tcagtcagtc gtttcagccg ttcatcactg tatgccgctt gaagctcttc 1859101 tgtcacatca tggccgattt catcaaagtc accgaatctg acaccttgtt ctttccaagc 1859161 ccgctcaaac acaacattgg aagcttcaga tctaagtttt aagatcgcct gctgaaagcg 1859221 ttcaggtaag ccgaagcgtt cttcccgctc tccatcggtt aatttaactt gcataggaat 1859281 gccgctgaac atctgcacaa aaacttttac ctctccaaaa gattcttgat cagaacgatt 1859341 ttcttctgcg ctttcagcac tttccatccc aaatgcagtg cggacttgcg gtaaaatgtc 1859401 tttccagtcg tatcttgcat tccgttcaac agcaagaaaa tctgcgacgt gatatacccc 1859461 tttaactcca tctattttaa ggatttccgc tataacaagc ggtgcgcctt ctgcttgctc 1859521 aggtttatag ttattgcttt tgcccgccgg aagctcttcc gttaagatga ctttcattgt 1859581 attcgggctt ggtgtaggtt caattgattt tatcttcatg atcgtcctcc tatagcatat 1859641 ctgtgactta ttctatcata gtcgctccaa gccttctatt acgacgtttc ggcatcaatc 1859701 ccgggtatgt ctttttctaa ttggcggaca aattgaagca taaaattgtg tctttcttct 1859761 gccagttccc gtgcagtgtc tgtattcatc atatctttca gccgcagcag cttatgaaaa 1859821 aaatgagcgt aggcgctttg ctcatctcca taaaggccat gcccttttgc gcccgcaaac 1859881 atgaaagctc tcgcaatgcc gacagcacca atcgcatcaa gtctgtcagc atcctgtaca 1859941 gcttttcctt caattgagag cggctccttc gccaatttcc ccctgtcccg aaaggacatc 1860001 cttgttataa tatgaatcac cctgtcagca ttctcttttc ctactccgaa aaaaacgagc 1860061 tgatcatata cttcgctcac agaaagcctg accgtgtcag gcagcttcac atcaattaaa 1860121 tcatgaacca aagccgccgt ttcaacaatg aacaaatccg ctttttcctt ttctccaata 1860181 tacgctgcaa gatctgctac tcttgataca tgatgccagt catgtccaga gctttcgtca 1860241 gtcaggatag attgaaccca tgtcctgatt tgctctgcct gcttcaattc cttcacaaaa 1860301 acaccctctt tttattgctc taatagcttc acgatatcgt cttccaactc tttcggattt 1860361 gtatttggtg aataacggcc aacgatttct ccatttctat ccactataaa tttcgtgaaa 1860421 ttccacttga tcgccttagt tcccagcatc cctttcgcat gttctgtcaa atacacaaac 1860481 agcgggtggg cgtttttccc gtttacatcc acttttgaaa acataggaaa tgtaacaccg 1860541 taatttgttt cacaaaattc ctgtatgtca gcctcttcac caggctcttg gttcatgaat 1860601 tgattgcagg ggaaccctaa gatctccagc ccctcctgct gatatgtatc atataattcc 1860661 tgcagctgct tcaattggga agtaaaaccg cacttacttg ctgtattcac gatcatcagt 1860721 acctttcccg cgaaaggctg aagtgtcatg tctttccctg tgattgtacg taccttcata 1860781 tgataaatag acatgtaagt ccctcctatg tccttggtgc tgattatttt acctttttta 1860841 aatcgcaatt caaaatgtaa acatcaatta agaactcata agaaacctaa cgatatgagc 1860901 gtcagttcat tatcaattca tatggctcgt tttttatctt atcattctat aaaacattac 1860961 aattccctct tacatctttg aaaatcattt tactgtgaaa ccaaaaggcg tgtcagtgcg 1861021 ttttatttaa agagttttct gttgtttccc cctcaacacg tatagataga ttgaaaattg 1861081 gcgtgaaaat tcctataatg aagaaaatta aacggggaaa taatggaggt ggcacgttgc 1861141 ctattaatat accaacacac ctgccggcaa aacaggtgct tgaaagtgaa catatatttg 1861201 taatggatga aagcagagca tttcatcagg atatccggcc gcaaaaaatt attatattaa 1861261 atttgatgcc gaaaaaaatc caaacagaga ctcagcttct cagattgctt ggaaattcgc 1861321 ctttacaggt tcatttcaca tttttaatcc caagcacaca cacgccgaaa aatactgcga 1861381 gagaacacct tgacgaattt tacacgactt tttccaatat ccgtcacaag aggtttgacg 1861441 gcatgattat caccggtgcg ccgatcgagc atttggcgtt tgaagaggtt tcatattggg 1861501 aagagctcaa ggaaatcatg gagtggagca aaacaaatgt cacttcaacc ttgcatattt 1861561 gctggggtgc tcaagcaggt ttgtattacc attacggtgt ggaaaaaatt caaatgccga 1861621 aaaaaatctt cggtgtgttc gaacataccg ttctttcaaa acacgaaaga ttggtaagag 1861681 gttttgacga gctatactac gtgccgcatt cccggcatac agatataaat atggaacagc 1861741 ttcaagcagt gcccgagtta aacattctta ccgcatcaaa ggaagccggg gtttgcttaa 1861801 ttgtgtctaa agacgaaaaa caagtctttt tgacagggca ccctgaatat gatacaaata 1861861 cgcttcttca agagtatgaa agagatttgg aacgaaacct ttctactgtc gaggccccta 1861921 aacattattt tgcaaaaggc agcaacgagc cagtgaatcg ctggaaagcg catgccacat 1861981 tattgtttat gaattggctg aattattacg tttaccaaga aactccttat gaatgggact 1862041 aatttttctt tttttagtga tacgctgagc aaaaaatatg ataaaataca tctgattcag 1862101 tctgcgtata acaaaaattt aaaatactgg aatccaaatc atttaaaatt agcttaactt 1862161 tttcactgca ttaataattc gattatgtat ttgtgttatg tttatgtata gacaataact 1862221 ccttacgatg catgaagctt gcttgttgtt gattacattg aggtgaattt acttgaatac 1862281 caataaaaga gtattaattt tgactgcaaa ttacggaaat ggacatgtgc aggtagccaa 1862341 aacactttat gaacaatgtg tacggctcgg ctttcagcat gtaacagttt ctaatttgta 1862401 ccaagagtca aatccgattg tttcagaggt aactcaatac ctttatttaa aaagcttctc 1862461 aatcgggaaa cagttttatc gtttgtttta ttacggagtt gacaaaatct ataataaacg 1862521 taaattcaat atttacttta aaatgggtaa taaaagattg ggcgaacttg tcgatgaaca 1862581 tcagcccgat attattatta atacatttcc gatgatcgtc gtgccggaat acagacgccg 1862641 aactggaaga gtcattccta ccttcaacgt tatgactgat ttttgtcttc ataaaatttg 1862701 ggttcacgaa aacgtggata aatattatgt ggcgacagat tacgtgaagg aaaaactgct 1862761 ggagatcggc actcatccaa gcaatgtaaa aatcacagga attccaatca ggccgcaatt 1862821 tgaagaatcc atgcctgttg gcccgatata taaaaagtac aatctttcac caaacaaaaa 1862881 agtgcttctg atcatggcag gtgctcacgg tgtattaaag aacgtaaaag agctgtgcga 1862941 aaaccttgtc aaggatgacc aagtgcaagt agttgtcgtg tgcgggaaaa atacggcttt 1863001 aaaagaatct ttgagtgcgc ttgaagcgga aaatggtgac aaattaaaag ttctgggcta 1863061 tgtggagcgc attgatgagc tatttcggat cacagattgc atgattacca agcccggcgg 1863121 cattactttg acagaagcca cagccattgg agtgcctgtc attctgtaca aacccgtgcc 1863181 tggccaggaa aaagaaaatg caaacttctt tgaagaccgc ggagctgcca tcgttgtgaa 1863241 ccgtcatgaa gagattctcg agtcagtcac ttcccttctt gcagatgaag ataccttgca 1863301 tcgcatgaag aaaaacatta aggaccttca tttagcaaac tcctctgaag tgattttaga 1863361 ggatatcctg aaggaatcag aaatgatgac cgccaaacaa aaagccaaag tgctatcgta 1863421 atggcgtact tgagagcata cgaaaatcgt gtgctctttt tatttatatt cagccatcaa 1863481 taaaagcggt tacatttttt tatggaactt gcccttcttt tgaaaaataa gccgtttcgc 1863541 aacttgacgg gtgctcccag atggtgtata gttgaaccat catttaacaa tgaatcaaag 1863601 ttagatgatg acaaaatttt ttttagcaca tgggtgctac agtactagga ggaattaagc 1863661 aatatgcaaa acggtaaagt aaaatggttc aacaacgaaa aaggattcgg cttcattgaa 1863721 gttgaaggcg gagacgatgt atttgttcac ttcacagcta tcgaaggaga tggatacaaa 1863781 tcattagaag aaggacaaga agtttctttt gaaattgtcg aaggtaatcg tggacctcaa 1863841 gcttctaatg ttgtaaaact ctaaactcaa tacatgatga tgagatgaca aatagaggag 1863901 aggcattcgc ctctcctatt tgattttcat ctggatttca atcgccaaaa tgttttgttt 1863961 acacctctgt tcaatctctt caacatactt ttccattgat ggttttcctt ttttcgcgat 1864021 atcggccagt tcttctaaat cactgtatat ttctataaat gttttgtgaa ggatcaactt 1864081 caagtcttta tcatccatag ctgcgttccc cttctctatc aagatacctc aaatagtaaa 1864141 acggtcctat ttattctggt tcaatagtta tatcggctta tttttatttt cttttctatt 1864201 ttggtacata aatttcaaaa aaactctgca aaataatggc ggaggtgttt tttgtgactt 1864261 cagaatttca taatgaggat cagaccggct ttacggataa gcggcagctg gaactagcgg 1864321 tggaaacagc gcagaaaaca acaggagccg cgacgagagg ccaaagcaaa acattagtcg 1864381 actctgcata ccaagccatt gaggatgcta gagaactgtc acaatctgaa gagctggcag 1864441 ctctcgatga tcctgaattt gtaaagcagc aacagcagct gctagatgac agcgagcatc 1864501 agctggatga attcaaagaa taaaaaccgc agcttctgcg gtttttattt ttagtgattg 1864561 gttaagacat ctccgtattg tttcaacttt tcaccaaccg tacatttatt gatacaaaat 1864621 gaatgcgcat aagttttgcc aaattctttg cgaaactgct tcttaataaa acagtccttg 1864681 caatattcat cgtgcagttc tgtcagttct ttaaagatca ttttcttatc caatatcgtc 1864741 atctccgtta cggtctaatt tcgtgtggct ttctacgaat tgatgggata gaattttttt 1864801 agcgaggccg tcagcttcct gattgtcttt tcgttgtatt gtttcgtagg ttggagtaag 1864861 cttcagcgat tcaaggagtg cttctatttt gtccagccat tcattatgag atggatcata 1864921 acaaggccag ctgccgtcaa gctgattcag cacaacaagc gagtcccctt tgattgtaat 1864981 tgaatttctg cttgccccaa gctctcttac ttctcttatt gcttcataaa gcgctgcgta 1865041 ttcagcttca ttattggttt tcagccggaa gcttttattt tttctcaagc gatgccgggt 1865101 tcctcccaat gaataataga tgacgatccc gagaccggcc agttcgctct ctttatcgaa 1865161 actgccgtca aaataaacag taatgtcatc aggctcttga gcaagctcct ctgtcagctt 1865221 ttccaattcc ttcagcgtcc agctgccgcc tttctcgtct tcgaactcta gctccttcat 1865281 gtatggaaaa cggccaagtt ctctggcgaa cgtacgtgcc tgctgtgctg tcagccagtc 1865341 ttcgctaaaa aatgagacgg atcccgttcc ttttgcttct attttcaaat gcggtctgag 1865401 cttcattaca atcaccttac cattcattag ttgccgggct tatgctataa tcaaaccaat 1865461 cttaccccgg aaaggaagct ttttcatctt gtttaataat tcgttttgga tcttttttgc 1865521 gatcattcat tttatcattg ttcttttatt ttataaagga tttggcaaaa tgggactgtt 1865581 tgtttggatc ggttttgcga cagtctgcgc caacctccaa gtcgtcaaaa cagtcgaact 1865641 gtttggctta acagcgacac tcgggaatgt gatgtatggc acaatctttt ttgcgacaga 1865701 tgtgctgaat gaaaaatacg gaccagctga agccagaaaa gcggtatggc tcggattctc 1865761 aacgctcctg acgctgacat ttgtcatgca gggcgtgctg cttttcgaac cggcttccag 1865821 cgacatatca caaacagcgc tggaaacgat cttcggattc cttccgcgag ttgcgttagg 1865881 aagtctgctt gcctttatct tcagccaaac gctggatgtt tatgtatatt cggcaattag 1865941 aaggatattt ccttctgatc ggcttttatg gctcagaaac ggcggcagta cagcagtcag 1866001 ccagttgttt gatacattca tattcactgc agtcgccttt ctcggcattt atccggcaga 1866061 cgtgtggctt catattttta tttctacata tttgattaag tttgcggtat ctttaatttc 1866121 attgccttat gcctatgcag ccaaaaaaat gatacctaat gatgaaagga gttcataatg 1866181 cctacagaaa tatatgtaga cggcgcaagc gccggtaatc cagggccttc cggtatcggc 1866241 atttttatca aacatgaggg aaaagcagaa tctttctcta ttccaatcgg agtgcataca 1866301 aaccaggaag cggaatttct tgcattaatt gaagggatga agctatgtgc aacgcgcggg 1866361 tatcaatcag tttcctttcg aaccgattca gatattgtgg aacgcgccac tgagcttgaa 1866421 atggttaaaa atataacgtt tcaaccgttt gtagaagaga tcatccgatt aaaagcggca 1866481 ttccctcttt ttttcatcaa atggataccg ggcaagcaaa accaaaaagc cgatcttctg 1866541 gcaaaagaag cgattcggct gaatgaaaag aattaaatct tgatcattgg ttcatcctaa 1866601 tggcgaggtg aactaacatg aaaaagaaag ataaaggccg gctgaccggc ggtgttactc 1866661 cgcaaggcga cctggaaggc aatacacata atgaccctaa aacagagctt gaggagagag 1866721 caaaaaaaag caatacaaaa cgctagagag gatctaaacg atctctctag cgttcagctt 1866781 ttcaagcata cgctcaattc ctttaatttg gtggcggcga agcatgtcag ccgcctgctc 1866841 catttgcaaa gtaaataaag cgtctttcag tgtgcaggcc agcggcactg agcaatggat 1866901 ttccgcaagc ttcctcgaca tctccaaatc gcttaaacct tgctgaattt ttccctgctg 1866961 tccttttgga agaagagaaa gattttccaa taaacggtca atcgtttcgt attcacgaat 1867021 cagtttgtag gctgtttttt ctccaatgcc tttgactccg ggatagttat cactggaatc 1867081 acccataagc gctttaatat caatcaaagc cttcggcatt acgcctgttt cttcataaaa 1867141 agtctctttt gtatagactt tataatttcc gattcctttt tgaagcaaag caacgcttac 1867201 tttatccgtt aacagctgaa gtaaatctct gtcccctgtt accaccgtaa tgtccgcttc 1867261 attcgcaaat aaatcggcaa gagtaccgat acagtcatcc gcttcatagc cggcaaagcc 1867321 aatattcatg attccaagct ctgcggctgc ttcctttgcc aaatcaaact gcggaatcag 1867381 ctccacaggc ggcgcgctgc ggttggcctt ataatcttgg aacaagtcat ttcggtacgt 1867441 tttgctcccc atgtcccagc agcagacgac gtgtgtcggc tggaatgttt ccacagctgt 1867501 aatcaaatgc tttaaaaagc cgttgacgcc gttcgtcggc accccgctgt catttatcat 1867561 aaagttgcga tgtacggccg tggcaaaaaa ggcccggaat aaaagagcca tgccgtcaac 1867621 cagcaatagt ttattattat tcatcaaata actccctttt ctttcattcc ttctatttta 1867681 tcataaagca gcccaaaaat aaaaaacagt atctctttaa ttagagatac tgtttgaata 1867741 tttatcaatc gttgtgtctt ttgttgctgg cgatcagctt ttcagcttcg cgtcctgcgt 1867801 aagagtcaaa atgggtttga aatccgtttt tctttttggc gttgttattc gcctgtgcat 1867861 ttctgtttcc gagctttgtt ctgcccaaca tgaatccccc cttacgtcgg atgcatatag 1867921 tatatgcttc cggcaggagg ttcactcgcg acaggatcat ccagcttaca tgcggcttac 1867981 gtattctctg accatttctt ttgatacaag ccgtcttgtc gggacgatgc cttttttagc 1868041 gagctgattc atttgctcgg taatttcatt aattgcatct gtagtataag gctcatcgtt 1868101 tctgcattta gcaacagctt cttcaatcgc caattcacgc atattttcaa gacgcataaa 1868161 tgctttgata tgctcgtgct gttttgatga atgtgctgaa attgctttat gtacctctga 1868221 cattaatcgt tcatctcgct tttttctatt tagtctatca tgacttgaaa tacaagccaa 1868281 ctgaatttta catttttatt gtattgtctg aatttttcca ggagatgcac gcctgatacg 1868341 ccatttcaat ctctttcgca tgttcccctt ccgcatatcc tcttaaatat gtctcttttt 1868401 gatccgttat ttgcgcgatt gctttttcac ccatatcttc ctgtaagcgt ctgaggtgag 1868461 cagtgtaatg agatatcagg ctttcttctt cattttttat ccatgcctct gtgattttcg 1868521 taagtttcat ccgtacagct tcgataaagg tcgcttttcc tttctgctca aaaaactgct 1868581 tcggtgattt gatctctttt agttcctgct caaaagcacg ttcttctatt tccggttcaa 1868641 cttccttcaa ctgtatgccg ttcgaatgct gatcacccgc ataaacggaa aaataaccgt 1868701 cctcgtttaa tgttttttga aaatgatcca gccattcttc attgatatgc cgttcgatga 1868761 aaccgctcat gcgaacatca agcgttttga tttcctgaat atattcaaat agatattcat 1868821 gtaaggctgt tgtcatcgct ttactgacgt tctttttcca atccccgttt tgcagcccgg 1868881 gatgaaatgc cgattttaat aaatcatttg caaaatatga taatcgctgt gcaatgtgat 1868941 atagctgctc tcttgtatct ttttttactt tttcaatgat ggtttttgag ttccgccgtt 1869001 tctcgatatc ggccgctgtc cgctcaaatg acagcataag gcactgtttc tgcgcttcct 1869061 tctcttctcg ggactgatgc tgggattggt gaagctgaaa aacagtttcg catagtttgt 1869121 ctgcctccga actgagctgc gctgctgacg ctttttttac atccacttcg ataaaccggt 1869181 ctaagtgttt tcttactttc gagaactgat tataaaatga ctccggtttt cccaccagtt 1869241 cctccttact tgatacggta aagagctgcg gctcataaac cccttctttt acaagctctg 1869301 cgctgacata atcggtcact gtttcgagct ctgttttatc ttttgcaagg tctgcagcat 1869361 taataataaa aaacatttta tccatgctga gcgattcttt cacaagtcca agctttcgca 1869421 aaaatgaacg gtctcctttt gaaaaagagt gctgataata agtcatataa aaaaatgcat 1869481 cagcatcttt gatatattgg aatgccagtt ctgtatgccg tttattcatg ctgctcgcgc 1869541 cgggtgtatc aacgatcgta atcccttttt cagtgagcgg gcatgtatag tagaccgtta 1869601 cctctttcac agcacaggcc gttgtttcct ctgctacata cggctttaat tcagagagcg 1869661 gaatcgttaa tttcttctgt tcctgtatat actgctgata cttctcgtat gcaagcagga 1869721 aattgctgat caatttcacg tgttcttcct gcagcctgtt ttttttgact gccttttccc 1869781 acttctctgt gaaggaacgg cctgccggct cctttggtat tccggtgagc tgcaaaattt 1869841 cagccgttaa gtcatcctct gtcttaaaca ctacattcgc tgttttgttt aagttgccat 1869901 tgattggctt tgtgatcttg ttaattgtcg ctgtggttgg cgttggtgag gatggcagca 1869961 ctctttcgcc gacaagcgca ttggcaaatg atgatttccc cgagctaaag cctccaaaaa 1870021 gagcgagtgt aaatttccgt tcctcaagcc ttttcaccct ttcacgaaac gctgaagttt 1870081 gctttaacaa catgctgcat tcgcctaaaa tgtcagacaa agtgtaaaag cgtttgattt 1870141 ggtcttgaag cggcatttct tgttccattt tgatttctga tttcggcatc ggctgcgccg 1870201 tcagctggct tcggccttgt ttctgctctg gagccgccac tcttgttttc ttcgatttaa 1870261 accattctgt gtctatatgc attgggcatg cggactcttc ttcccaaatg gcccacaggc 1870321 gatcggtttt ctctcgggca ttattctcta aacgtgcctg ttcttgaaga aagacaagtt 1870381 tttctgattc ttggacgagc cggtcgttaa ttgtttgcac atctttggaa acacgctctt 1870441 tcaccatagc ggagagcacc tttatgatgt ctgcggcttc tcttttcgcc tctttccgga 1870501 tgagctctgc caagtctttt gtatattgca atacatattc agaggaaaag gctgcaccat 1870561 gcttgaccgc gtgttcaatg atgcttatat caagcggtgt gcgataggcc tgaatcagct 1870621 tttcactttc agcggtatag acatcaaata ccttggcgag tttatgaagc gtgtctatca 1870681 tatgccaatc cgcttcggcc tctgttcgtt ttgccacatc agagaaaaaa gcattccgcc 1870741 ttttatctct ttcctgtgca gttttcgctt tagaaaagaa aaagccggtt ttaaaggaag 1870801 gctcttgtga ttctaaaaat gcagccgcca attcacgcat ttcaaaaggc gtcaggttgg 1870861 cgttttttaa aatacgattg atttcttcct gcatcctctt ctctgcctca gtcatttgtt 1870921 tttcggcctc atccaattga tcacgcagcg attggaccag tccagtatgg atattaagct 1870981 gttcagcgaa actcggagcg cctgtttcgt ctttcttcag catttccgta tgttccttta 1871041 gcagattacg gactttttgt tcggttaaag cctgcatatt gctttttgat tgctgttcta 1871101 ttctgcttaa ctcttctctc agggccccca tctgattgaa cgggtgatcc ggttctgtta 1871161 ctgatgtaaa atagagcgct tcccttgaaa tcccttcatt gcaaagcatc tcctctacct 1871221 gcgcttgata gtctccaaat ttcgtctccg tctcatcatg gcggtcaatt tgattgacga 1871281 taaaatacac attcggaatg ctttctttta ttgatctgag aaactttaca ttttcctcag 1871341 cgtgcacgtg attatagtga acgacgtaaa acagcgcatc cgcttggtga agaatagaag 1871401 cagccgatag aaaatgcgca tcatctgttg aatctatccc tggagtatca atatacgcaa 1871461 ccccggaatc gatctcagta tacctgtcaa aaatttcgac gctttcaatc tgttccccgt 1871521 ctttacaata ttgctgcacc ttgtctttct ggtaagtccc ttccagctca gcacacgctc 1871581 cgtctgttgt atgaagccga actcgctttt ccccgtttct gatcacaaca aggttagcgc 1871641 ttgtcggaat cgggcttgtc ggcaaaatat tctccattaa caggcagttc agcagtgacg 1871701 atttccccgc tgaataatgc ccggtaaacg cgatataaac ctcttcatca gccgcttttt 1871761 tcatgaccgc agccagttta gcagcccttt gttcatcttg attctcaata aattgcttat 1871821 aaagttcccc ggttttatgc aaaagctctt ttctgttttg atctgtcata agtctgaacc 1871881 cctttgtgcc gtttcaattg tgaacctttt tcgaaagatc tgaattcatt cccttttcat 1871941 tttacacaag aataaaccaa atttctttag gagaatagaa aaaagccgcc attacggcag 1872001 cttctataaa agaaaatctg caacttttac aagttccaga ttcatcaaac agatttatta 1872061 gagattcctt ttaatacaaa accaattaat acactatatg tacaaaccgc tccaagcaaa 1872121 aacagcattg tcatttgctt caccatcctg attgagaatc tttttcaaac ccattttaac 1872181 atggttgaga atgattttca atcgctattt tacgctgtat tcctgtaatg ctttgtcttc 1872241 tgcgcgaatt ctgacgctta acaacacggc attgaaaatg gaaaacagac acatggtgac 1872301 gtatgcttga taaagcagcg gaatcagcaa aatttcgagg ataacaacgg catagtttgg 1872361 atgtttcatc catttatatg gacctttttt tacaagctct acacctggaa caacaaggat 1872421 tttcgtattc caatatgctc ctaaggaaca aagcgcccaa taccgtacga tctgtacgct 1872481 taaaatcact gcagcgatac cgagccacca gctggacggc tgtttattca tcagcagcac 1872541 ctcggcaatt aaggacagga aaaaaaggat atgcatcgta atgatatacg gatagtggct 1872601 ctcgccaaat tcaattgctc cttgcttctt taccttttgt tcgttttgcc tggccactgc 1872661 catttctgct gctctttgaa caatgagaat ggcgatcaac aaccaaaaca tgagtcaggc 1872721 ccccttttcc cagctgaata atagcaactc tgatgagaaa cccggcccta atgcgccaat 1872781 cagtcctcgt tcagcttcct ttttatgtcc gttctgcaga tggtctttga tcacatacaa 1872841 gattgtggct gaagacatat ttccgtgctt ttgcaaaatg ctttgcgcag atgaaagctt 1872901 ttctgacgac agcccgagac ttttgatgta tgcatcgatc actttttttc cgcctggatg 1872961 cgccaaaaaa acactgatat catggaatga cagcttatgt ttgtccaaaa aaatctgtac 1873021 atttgttttg agccattttt ccaccaaggt cggaatgtct cgtgagaaaa tgactttgaa 1873081 tccttgatcg gtaaagtccc agcccatgac atcttctgat tgtttcatca aaacagattg 1873141 ggcgtccatt atcttcggcg caagcttcag ctttgacacc ctgcggtccg ccttctctcc 1873201 gcataataaa gctgcggcaa tgccgtcacc aaaaagcgag gtgccgatca gattgctttt 1873261 tgttttatct tccggctgga atgtcaggct gcacagctcg gcagaaatga caagcacaaa 1873321 agcctcagga tacgctttgc agtattcggc tgcacgcgca agtccgctgg ctcctcctgc 1873381 acagccaagc ccccaaatcg gaatccgctt cgtatatgga gaaaacggaa gttcattcat 1873441 aagccgcgcc tcgatactcg gtgtggaaag acctgtactg gagacgaaaa aaacagcttc 1873501 cactttctca taaggaatgg cttcttgaaa aaattccgga tgagagaggc actcacgaac 1873561 agccgctctg ctgtgtttaa gtgtttcttc tatgtatatt tgattttttt cttcaaagct 1873621 gtgcccctct ttataccatt caatcggctt aacaaactgt ctcgaatgga tttgcccgtt 1873681 tttaaaggag gataacagcc tgtcaatatc cttaaaagaa tgctgaaaca tatagcgggc 1873741 gaactcggcc gctttctctt ggtttacatt atacgcagga agacttgttc caatggataa 1873801 aataaacgcc atgcgatcac ctctttgcat acattgtgcc gcaacaatct tttttatatg 1873861 caaaaaaaac tccgccgcgg cggagttaga ctgctgtttt ttgttcagcg aggtcagctt 1873921 cttgttctat ttttttagct ttagaaaaaa cgttatatac aatatttaag acgactgcag 1873981 taaagctgcc cgccacaatg ccattcgttg taagcagcgt taaggcactc ggaagctgtt 1874041 tgaaaatatc cggcacaacg gtcacaccga gccccaatcc cactgagcaa gcaacaatca 1874101 gcagattttc ctgtttcgca aaatcaatgc ggctgagcat tttaattccg taagcaatca 1874161 ccattccaaa catcgccacc attgcaccgc ccaaaacagc ggatggaata atagtcgtga 1874221 aagcagcgat ctttggaaac agcccaaatg ccattaggat cacacctgtg accacaatga 1874281 cggcattttt tttgatccct gtgagctgaa caagcccgac attttgagag aatgccgtgt 1874341 aaggaaaagc gttaaaaata ccgcccagaa gcacagccag tccttcagct cgatagcctt 1874401 tagacaaatc tatctctgtc aaacggcggt ttgtcaggtc acctaaagca aagtaaacac 1874461 cagttgactc cacaaggctg acaattgcaa cgatggacat cgtaatgata ggcgctgcgt 1874521 gaaaagacgg cgctccgaag taaaatggct gaatcatttg aacaactgcc gcgtccgaaa 1874581 cattatcaaa ttgaactttt cccataaaat atgcgatgaa ggtgccaatc aaaataccga 1874641 tcaaaatcga gacggacttg ataaagcctt ttgtaaaacg gtatagaagc acaatgatac 1874701 tcaacacggt aaaagcaagt gcaagattgg agagatctcc gaaatctgca cttccttctc 1874761 cgccggccat gttattcatg gcaaccggca tcagtgtaat accgataatc gtaacaacag 1874821 agcctgtcac gaccggcgga aaaaacgata cgagctttcc aaagaaaaat gaaataagaa 1874881 tgacaagaat gcctgaagcg ataatgctgc cgtaaactgt tgaaacccca tattcagatc 1874941 caatcgctat catcggcgat acagctgtaa aggtacagcc aagcactacc ggaagcccga 1875001 tcccaaaaaa tcggttgctc cacacttgca gaagtgtagc cacaccgcac ataaaaatat 1875061 caatcgatac taagtaagtc agctgctcga cagtcagtcc cattgctttt ccgacaatca 1875121 gaggaacgac aatggcgccg gcatacatgg caagaacatg ctgaatccct aaagacagcg 1875181 ttttgccgaa tccatttctc atgaatgaac ctcctgtacg aaggacactt ttccttcttc 1875241 taaagactga attcttgcca aagattccac tcggtagccc agttttacaa gttcatctct 1875301 tcccggctga aatgactttt caataacaat gccgattccc gcaatagaag ctcccgcttg 1875361 cttcacaatc gacacaagcc cgtgcgctgc ctgtccattt gccaaaaaat catcgataat 1875421 cagcacatga tcctgatccg acaggtgggt cccagacact gcgatttggc tttctgtttg 1875481 cttcgtaaag gaataaacag acgctgtcag caagttgtcg gtgagtgtta acgatttatg 1875541 ctttctcgcg aagacaactg gcacacccag cttcaagccc gtcattacag cgggagcgat 1875601 acctgatgat tcgattgtca caattttggt aataccgtct tttgcaaacc tagacgcaaa 1875661 ttcatcacca attctctgca taagcagcgg atcaatttgg tgattcaaaa aagaatccac 1875721 tttcaatacc tgatcagata atacgacgcc ttcttcctct attttccgtt tcagtgcttc 1875781 catcctgtct acctccgtta tgagaataaa aaaagcattg cccgctcaaa taaagagcaa 1875841 gcaatgctga tatcacaaaa aaccgtacac gtgcggttcc attgctcacc catagtcgga 1875901 catttacggt gcccggtaga aacttgcgtg ccatatccac gcgattatat gagtgttcct 1875961 attatattgt aataaattat atcaagattc taatctcttg cataggctga aaataaaaat 1876021 tcccgaactt taattttgtt tttttagata tcattcgtat ttcaagggga ttcgatataa 1876081 aagagtctga cgaccgcgcc gccaggcttt tgattataac agatagagat ttgaatattt 1876141 gtttgataaa taatcaatta aatagcgaac attcagctct tctcctgttg catctttaat 1876201 aatgtctaac ggctttttcc gttttccgtg aatgtgcacc ttttccgtca gccattgctt 1876261 tatcggatgg aactctcctc tttccaagag agcgtcaaat tcagggagat cctcaagcat 1876321 tttttgtttc agctgagccg catacatgta gccgagcgca taggatggga agtagccgaa 1876381 atctccacct gcccaatgga cgtcctgtaa aatcccctct gcgtcggtct gcggtgtaat 1876441 ccctaaataa tcctggtatt tttgattcca aagcgacggc agatcttcca cagacacttc 1876501 attgctgaaa atcgcttttt caatttcata acggatgatg atatgaagag gatacgtcaa 1876561 ttcatccgct tcgaccctga taaatgaagg ttttgattca ttgattgccc ggacaaaatc 1876621 atccagggag atgtccttga actgtacagg tgatgcctct tgaatcttct tatagtacgg 1876681 agtccaaaaa tgcttgttgc ggccgataaa attctcgtaa aataatgatt gcgattcatg 1876741 aattcccatc gatgcgccgt ctgacaagtt cgtgccactg agtgcttcat caatattttg 1876801 ctcgtaaatc gcgtgcccgc actcatgaat ggtcccaaag atcgccgtcc ggaaatcttt 1876861 ttcatcatat ctcgtcgtga cccgaacgtc tccccgattc agcgtagttg caaacggatg 1876921 aacggtttca tcaagtcttc cgccatcaaa atcgtagcca agctcctgta aaaaatacag 1876981 actgagctct ttttgctttt ctttcgggaa cgcttttgta ataaagcttg tatctggttt 1877041 atttccggaa gctgtcacct gtttaacaag agggataatc gcttccttca gctcagcaaa 1877101 caactgatca agcaccttta ccgtgacgcc gggctcaaac aaatcaagca atgcatcata 1877161 aggatgctct tgatatcccc aatacgtaat aaaacgttta ttgaattcaa tcagctgttc 1877221 taaataagga gaaaacaagc tgaaatcaga ttttcctttc gcttcctccc acgctgtttc 1877281 tgcctttgaa cacagaatca cgtattcttt gtattcagcc tcagggattt tcttattctc 1877341 ttcatactct tttttcgcca gttccactgc ttttttcgta tcttccgaca agtcatcaaa 1877401 tcgttcatac aggacatcga taagctcctt cattcgatct gatgtttgga tattgaatat 1877461 atctgttgaa agctggccga tactttcggc acgatcctct gagccatttt tcggcgcgcc 1877521 tgttctggag tcccagtgca ttaacgcaac tgcttcgctg taatgtgaga ttctttttaa 1877581 aagatcaaaa aattcttttt catatgtatg tatctccata tccattccct ccctattcta 1877641 gccgttccat tacaggctaa tggaaggggg tatgaaagtc aaattgtttg tataaaaggc 1877701 tgccggtatg ttttgtggca gcctttttat tcagttgatc gtcatttgat tttttggcgg 1877761 aggtgttctc cgctttttct gcttgatttt tttatctacc cacactgttg ccagcggggt 1877821 taagagcgag gtgacaataa cgcttgtcgc gataattgca gttgccgact cagcaactgg 1877881 cgcaaatgag gcattcgctt ccgctaatgc atatggcacg gctacagccg cccctgccgt 1877941 agaagaagcg gccactcccg cgacaccatc tccccgcgca ataaaacgat caagcaaaaa 1878001 caaagaactg cccgataaaa tgacgacaga aactccgata aaaatgccga gcagccctga 1878061 ttggatcagc attccaaaat tcaaggtatt gccgagcgaa aaggcgaaaa atggaatgat 1878121 cgccggcaca accttgctga ataagtctct gagatcatga tccagatttc caagtataca 1878181 tccaagtaaa aacgggatga ctgtcgctgc cagcgtttcc catgggaatg cggcaagtcc 1878241 cgtcacacca aacgtcacca tggtcataaa aggaccagat tctgtactga taaaggcgaa 1878301 agcgcccgca tcctcttttc ttcccatgtg attcatgagc gccaaataca gtccgccgtt 1878361 cgtttcattc attaccgcga caattgctaa aacagaaagg cctgcaaaaa agccggattg 1878421 tatgccatcg tcaggtataa attgcgctgc gatcacgccg agcagcgccg caaatccgat 1878481 cttccccaat aataacgtga ttccttttct tgcgatatag cctgaagaac gaaaatcaat 1878541 cgttgctcct acgcaaaaga taaaaacacc cagtatcggc agcgttccgg taatcaaagc 1878601 acccgtaaac cctccaaaga actccgctgt tccaggcgca aacgtgttga gcgccgctcc 1878661 aagaaatagc ggaataatca tcattccgcc aggtacccgt tcaattgtcg ccttgatttt 1878721 catattgtgg attctcccat cctccggtta tgaaaaaaca attccactta cacttggaaa 1878781 acagcctgca aatcctcttt tgaacagctg cccaactggc tgccgactcc gacggcgcca 1878841 gctccggctc taagccaatc aggcacttca gacggatgta tcccgcctgt cggaataaag 1878901 gtcacctgcg ggaaaggacc cgctaaattt ttcataaacg gaatgccaaa cacaccgctt 1878961 gggaacagct ttaatgtcgt aaaaccgaat gtcagcgctt ccataatttc gctcggagtc 1879021 aagacgccgg ggatataatg tgtctttaca aaagatagat gttcagcaag atcagctgaa 1879081 aaacccggac tgacaataaa ctgcgcgcca gccttagcag cttccccagc ttgctgcgcg 1879141 ctgatgaccg tacccgcgcc aattaaaata tcttccctat tacggaagga ttcgataata 1879201 tctgatgccc cgggggtcgt atacgtcact tcaactgcac gaatcccttt atctaataaa 1879261 ctctcaatct gctgacaggc ctcctgctta tcctttgaac gaatgactgc aatcagcttt 1879321 gcttctttca gacggttttc aacgactttg gactccatat taataatccc ctttcttttg 1879381 gtgaaccgtt ctttgagcag ataaaaaaga agctaatttc tccctggtcg gcaaaccgtc 1879441 catatccccc ggtgcctgca cttgcaaagc gccaatcgca tttccccttt gcaccgcatc 1879501 cttgtacgac aaaccgtcta ggataccgct gattacaccg actgcaaatc cgtctccggc 1879561 gccgaccgta tcaaccaccc ggtcgacccg gcagccttct agaaatcctt cacttgtccc 1879621 cgttttaaag taagcgcctt cttttccaag tttaatagca acaaagctgg cacctttttt 1879681 caaataatag tcggcaatgc cttcaggtgt tttttctccg gtcaatagct ctccctctgc 1879741 gatacccggg aaaaaccagt ctgcaagccc agccagatca ttgattgtgt gtaccattgt 1879801 tgcttgatca ggccaaagcg aaggtcttac attagggtcg aatgaaatgg tcttccctgc 1879861 gtttctcatg tcgttcatga catgatacgt gaagtctttc atctcggctg ataaagcagg 1879921 cggaatacct gtcacatgca aatggcctgc gcattgaaaa taatctctcg gatattcagc 1879981 tgtagttaat gtgcttgcag ctgagttttt cctatagtag gtaacttgcg ggtcgccttc 1880041 tttcactttt gacttcagca gcagcccggt gggattttcg tcctgcgagc ggatcacgcg 1880101 ggacacatcc actccctctt ttttaagctc ttgtaaaata aacgttccga gctgatcatt 1880161 gccgaccttg ctcatccatc ccattcgaaa tccgagtctg gcaaggccgc aggcgacatt 1880221 gctttctgct ccggcaagcc ctttagaaaa agtggatact tcatgaaggc ctccatactc 1880281 atttgcataa aacatggcca ttgattcccc gaatgtcacc gcatcaagct tcatctcttc 1880341 ccaacctcct cttagttgag ggcacctagg attaaagtga ctttctcatg atgacttttg 1880401 cctctaattc aatggtttga ggcgctcctt tgtcaccttc aatccttttt aatacacgtt 1880461 ccatcgccgt cctgcccata tcatgtgacg gctgggcgat cgttgtaatg cctggaccga 1880521 tcagtttgta ccactccgta tcatcgaatc ctgcaatccc tatatcttga gggatgcgca 1880581 ggccaagctc ttccatacag ctgatgattt tcagcataat caagccattc aaagccagaa 1880641 tcgctttttt ttgctccggc atttccttgt gaaaagaacg aagctccgcc ttaagctgct 1880701 ccttgtcctt tacgtcaatt tcatgcaatc tgacaagccc gttcacattt tgaaccgaag 1880761 ccatttcctg atacacagct gctctttctg cacgagggct gatagaggaa atcggttcgg 1880821 taaacagcgc gacatcagta taccctttgc tgtacacctt ctgaagaatc tcttttgtga 1880881 tccatctgtt gtcagtcgtt acggtatcca gtttcagatc cggcagtttc cggtcaatta 1880941 agattgttgg aatttgctgt tcagcaaaag cgcggagtac atccttgttt tcccctgttg 1881001 cgtttaaaat caagccctca accgaatggg cttctagctt taagagcatt tcccgctctt 1881061 tttcaggact gttatctgtg ttgcacacca taatgctgta tccatattga tcacaaacct 1881121 cttcgactcc cctgaaagca gcgaccgaaa aaggatttgt aatgtcagcc acaacaaatc 1881181 cgattaactt gctttttttt attttcaaac cttgtgccat tttactcggc cgataattca 1881241 attctgcgat tgccttttta atgtttttca ctttttcagg agaaatcgcg tcaatttttc 1881301 cgttaatata gcgggaaact gtcgatttcg aaactcctgc acattcagct acgtctttga 1881361 tggttgtatg gcctgttgtt ttctttttca ttcaagtgct cctgtatctc atatatttga 1881421 aaccgatttc aaaaccgtta caacaaaaga ataccataat tttaaaattt gggaagagtt 1881481 tttttaataa tatgtcaatt cattattttt tcgttgactc ttttcactat ttatcctaaa 1881541 attttctttg aaaccgttac caaaatattt tcattcaagt gatgctgaaa tcctaaccaa 1881601 gggggaaata taatggaaaa tcgttattct gtacatcctg aacaagtaaa acgctttaca 1881661 acagaggagc ttcgcagtca tttcttaatg gattctttat ttacagaaaa caaacttacg 1881721 atgtattact cacatgaaga ccgggttgtc atcggcggag cggctccagg gcaaagtgaa 1881781 ctgaagcttg atgcaggtga ttttctaaaa acagacttct ttttggaacg gcgtgaaatc 1881841 gggattatta atgtcggcca gcctggtgcc gttagagtcg gcgatgatga atatgtgctt 1881901 caaacaaagg attttctcta tattggaatg ggcaatcagg atgtatcgtt ttcaagcctg 1881961 aacggggaaa aagcgaagtt ttacttcgtc tccgcttgcg cccacaaaag ctatccgaca 1882021 caaaaagccg ccctatctga actgacaccg gaccgccttg gtgatgatgc agcgtctaat 1882081 gtcagaagtc tgtacaaagt cattcatcag gatggcatta aaagctgtca gctgatgatg 1882141 ggaataacga tgttagatca aaacaacaac tggaatacca tgccagcaca cgttcatgac 1882201 cgtcggatgg aggcttatct ttatctggat cttgaaaagg actcaaaggt atttcatttc 1882261 atgggccagc cggacgaaac acgccatctt gttgttggaa atgagcaggc tgtcctttct 1882321 cccgcttggt ctattcattc tggcgcagga acatcaaact atagctttgt gtgggcgatg 1882381 gctggagaaa attacacatt tacggacatg gatctcattc caatggatgg gctgaaataa 1882441 gatgggttat ctacatgacg ccttttcatt aaaaggaaaa acagcgctgg tgacaggccc 1882501 gggaacaggg atcggtcaag gaatagccaa agccctagcc ggggctggcg ctgatattat 1882561 cggcacatca catacaagca gtctgtctga aacacagcag cttgtggaac aggaaggccg 1882621 gatatttaca tcttttacat tggacatgag caagccggaa gcgataaagg attctgcagc 1882681 tgagctgttt gaaaacaggc agatcgacat ccttgtcaat aatgccggca ttattcatcg 1882741 ggaaaaagcg gaagattttc cagaagagaa ctggcagcac gtactgaatg tcaatctaaa 1882801 cagcctgttt attctgacac agcttgctgg caggcacatg ctgaaaagag gtcatggaaa 1882861 gattattaat attgcctctc tcctgtcttt tcaaggcggc atcctcgttc cggcttacac 1882921 cgcgagcaaa cacgctgttg ccggtttgac aaaatcattt gcaaatgagt gggcagcgtc 1882981 aggtattcag gtcaacgcaa tcgccccagg ctatatttct actgcgaata caaagcctat 1883041 tcgggatgac gaaaagcgaa atgaggacat tttaaagaga attcctgccg gccgctgggg 1883101 ccaagcggat gatatcgggg ggactgcagt ctttttggca tcacgtgctt cagattatgt 1883161 aaatggacat attttagcag ttgatggcgg ctggctatcc cgctgacaaa taaaaaagct 1883221 gacgaacgat cgtcagcttt tttccattac atcatgtgcg gttcaacagg caagaccttt 1883281 ttgacctcat caatgatgcg ttcattttct ccgccagcgt aaatgtgaat cgagccgctg 1883341 tcttgattcg agcgaatcag gcgcccgatg ccctgccgta cacgtaacaa catatatggc 1883401 agatcaactt cttcgaacgg atcttttttc gctccgttgc gcttcgctgt aaatacagga 1883461 tcgtgtggcg ggaacggtaa tgaccaaatg gtaacattct tcaatgcgtc accgggaatg 1883521 tcgagtcctt cccataagtg aactgaacaa agtactgttt cttcttcctc ttggaatttc 1883581 tctactaagc tgctgatttc ctcatcacct tcgaagaaaa ttggatacgg cagctcccat 1883641 gccgccgaca gctctttaaa ctcgtttaat tcttcaaaag aagggaaaag caccagcgtt 1883701 cttcctttgt atcgtttgat tgtttcaatc gtttcagccg ttttttgttc agcgtccata 1883761 tctgtttttg cgtatagatt aatactcatt tgctcgtcat aatcataagg ggaatcaaca 1883821 gttaatgaca aataatcatg aatcccaaga ctgtcggcaa tataatcaaa cgaaccgcct 1883881 tctgacagcg tagcagaaga aaagatataa ggaattttct tagaaaacac tttttcgcca 1883941 agtacttctg ctaccgttct cggcatcacg acaaaggttg attctgcttc ctttttctcc 1884001 agccagctga tcgcatcctt ttgatataga gataatgaat acgccatttg ttcaacatat 1884061 tcttccacta ctgacagttc gtattgatca atcgtataca tttcagactc aaatacaagt 1884121 gcctcaccga ttttatcaag taaacggcaa agctcgtccg ccgccttttt gacacgatgg 1884181 tcatttttta tttctaaacg gtgtgaaccg gctacttcct ttgattcttc agaaagaaca 1884241 tagaaaaatt cgtcgtttgc gagaagcgca tcttcaatca attctgcaaa ctcttctctg 1884301 atgtcatttt gcagcaatcg ttctaaaaac aattcaagag tagactgctt cactctatag 1884361 gttagcgctt tttgcgcagc aaactctaac aagtgcccct catcaaatac aactgcacta 1884421 tgatcaggca agagcggcag ctggccctct cgtttgcgtg attcttccgt ccacacatgc 1884481 tccatataaa aatcatggga acaaatgatt aagtccgttg acttgcggta gtaatctctg 1884541 gaaagtgtca gaccgcatct gtgtctcata tcacaagtca gacagtcctg aaacgagtcg 1884601 tagcttacgt cagaccactc ttcattcgat agatttgcgt actgcttacg gtcgccatac 1884661 ggataaaagc gctgcatcgc ctgggactcg tggacaaatg acggtaacga ctcataaaga 1884721 tccagccatt tatcatcatc agaacgctgc attgtttttt caagcttctt caagcataaa 1884781 tattgctcat gtgattttga cagccttgta tcaattttca gatcaagatg ctcagccagc 1884841 ttagaaatat cgccctcttt tttcaccagc tgttcaatta atgtttcatc cgcacaagcg 1884901 atgatggcag gtttgccgac ataccttgca tagctgattg caaaaagaag atataccagc 1884961 gttttccccg ttcccactcc agcttcggcg aacatgactt ttttctcttt aaacgcccgc 1885021 tccagctgaa aagccataaa tacttgctcg tcccgaagat caaacccttt ttcgggaagg 1885081 atatcgtaaa acacgtcacc aatccaattg ttcaattctt cataaaaatt ctttgttttc 1885141 gttaaagaaa aaggcaaacg tgatgttgtc acctagttcc aacccccaac tattcgacat 1885201 tcagaccacc aataatatca ttttccgctg atgaatacaa taaaaaactt ggcaatgcca 1885261 agttttttgc agtttactta cgattgatca catgcgacga taaaaaagga tggtctgttg 1885321 aataaatatg ttctaccgct ttttctaaat cagtttgcgc atgcgaaatc acagacggag 1885381 acgaatcagt cccgagctcc ttcagctcgt ttgctgttgc gtcaagcgcc ctttgaataa 1885441 gattaaaatg ttcgctgttc agcatgagat cacctctgat ggaaataatc atcattgtat 1885501 gcgaactttt cattttatat acatgcttta ccgcatgtta tcaccgaaac atgcacaaac 1885561 tacacttgat attccgtctc cggattatcc gtcttatcaa caatattcta tcagggagtg 1885621 atgttgacat gagttataga aaccgattag atcagcattc tgaactgttt catcacaatt 1885681 ggacgcggcc taaacgttca aagtctcaag taaacggtca cactgaaatg tcccaaacca 1885741 acattatatt gagaagcaac gcgaaagctc accgttggta acgatagaat agggctgaaa 1885801 gatgaaagaa gacgcatgca gagcgtcttc tttttatgcg ttttctgttt tcttgcgctg 1885861 cggtcttact tttgaccagt attgataata atccgtttta ataaacccgt taaagagttt 1885921 tcgtttcttc gttgcttttc tgccatatgc ttcctcaaag ttttcatttg atgtcagcat 1885981 atacacagac caagtatcaa gcggctcgaa cgcctgcccc atttctttgt acatctgctc 1886041 aacggctttt ttctcgccga gacgctctcc atatggcggg ttgccgacaa ttacgccaaa 1886101 ttccagattt gtggtaaagt ctttgacctg catctgtttg aactggatta gatctcccaa 1886161 tcctgcttcc tctgcatttt cttttgcgat ttgaaccatg cggtggtcta tgtcgctagc 1886221 gaaaattgta agcggctgat cataatttgc cttttcttcg acttcaagcc gcgctttgtt 1886281 ccacagatct ttaccgatcc attcccaatc ctctgataca aaatcgcggt tgaatcccgg 1886341 ggcgatgttt tggccgatta gcgccgcttc tatcgcgatt gttccggagc cgcagaaagg 1886401 atcaacaaac gggcggtcag gcgtccaatt ggttaattgc accaaagcgg cagcaagtgt 1886461 ttctttaatc ggcgcaccgc cctgatcgac acggtatcct cgtttgtgaa ggcccgtccc 1886521 tgatgagtcc agtgtaatca aagcctgatc tttcaataaa gatatttcca ctttatactc 1886581 agcacctgtt tcttcaatcc aatcattggc tttgccggac tgcagcttga gcttttcgac 1886641 aattgctttt ttgacgatcc gctgacagtc aggaacgctt gcaagtgttg attttaccga 1886701 ttttccgatg acagggaatt tcccgttttc aggtataaat gagcgccagt taatcgcttt 1886761 cgttttttca aacagttcat caaatgtttt cgctttaaaa gaagcaacct gaacctttat 1886821 gcggtcggct gttctaagcc aaaggttcgc acggcagatg gcaagtgcat caccttcaaa 1886881 aataactttc ccgttatcaa ccttgcattc gtatcctaaa tctcgtactt cctttgcgac 1886941 aacagcttca atgcccatcg gcgccgttgc aattagtgta tacttcttca tcgtatcacc 1887001 ctgtctttta aaacttttct cttttcaaga taaaagctct ccttatacgg gagagcttgt 1887061 tttcatcatt ttaaatgtaa gtggtctaac gttctgtaag ccatgttttg ttccatcgta 1887121 ctgcaaacgg ctcatcacct cgtactcagg cggcaatcat ctatctacag aaagcattct 1887181 gtccttctct ccgttgaatt ccgttaagaa ggttccccta ccaaaatttg ggtttctcgc 1887241 tcgaggggtt taccgcgttc cactctcacc atttctagtg agacttcgtc actgtggcac 1887301 tttcaaggat actcagccat atccgaagac gtaggctttt ttcctgccgt cagcctctaa 1887361 agactgccct agcttatgac ttcgctaggc acgaacacta cgggcatctc agcaccgtgc 1887421 gagcatggac tttcctctac agattcaaga tctgcagcga ttacccgaac gttaagaaca 1887481 tgaattatta tataacaact gattacaatt tacaagcgcc atttttttca agcgtgatca 1887541 atcataaagc ttgctgccaa aaacgtgttt ttctaagtta gacagccgtt ttaaaatatc 1887601 aaagtttgtt gtgttagatt gcacaggctg ttttttgctg gcttcttcaa gctgtttttt 1887661 cagctgcaga ttttcctgct gcagttcttc aatttcttga tggaaggttt cataatcctt 1887721 aataatcata tctaaaaatt tgtcaacgtc ttcttgcttg tagcctctaa cgcctgtttt 1887781 aaattctttt tccaaaattt ctttcgcaga aagctttact ttatcagcaa gcatcttttt 1887841 cacctcgtat cgtgaatcat cacatatatt ttttcagaaa tctgtacggt tgtcaaattt 1887901 ctctctcatt gttagtagct gtcttcctcc actgtcactc tcaagtcatc cattgtaata 1887961 aagtagatgg gatagccatc ctgttcgcgc cttttttccg ctgtcccaag catatactta 1888021 ggggagcctt ccttttccgg gtcatataaa agcagaagcc cgtcggactt atcaatgaag 1888081 aactgatttt tttgtttgaa ttgaagcggg ctttcataag gacggtgagt caggcttgct 1888141 tcatagtctg cctgagccag aactgcttca tactgttctt tattcggttc tttccagttc 1888201 ttttcctgct cgtaaaatgg tgtgatgaca gctaccttta agtcagggta ttcctcctgc 1888261 aaatcatatg cagcttctgc cgcccacagc tcaactccaa gctggcccga aattaaaatc 1888321 cattctaatc cttcatccaa aaaagcaatc agccggtttt taatggcttt ttttatgtaa 1888381 tacagcgcct tgtcatcctg cttaaatatc cccagttcaa acggtttata gcccgttatt 1888441 gccaatactt tcatcatttc acctgcttta aaaaatgggg ctcccgtggg ccccatttgt 1888501 tgtgctgcat tgtttacacc atcaagctgc acgttttcca tactagtagt cgcagcaagg 1888561 ttttcctgct tgaaaatgct gatgcgtagc cgggtcaaca tttgagaaag tgtgtggaaa 1888621 gtagtgaacg tgctgaaaat gctggtggtt tacgtttgtt gtatgctgtg ggtgaatgtg 1888681 cggcacgata gtcttcgaaa acgtatggtg ttcacagcaa tgagtaggat ggacaattgg 1888741 cgccatcata tgcggtctgc agtgatgcat gataaaatcc cctttccata aactttatta 1888801 caatactaag ttatgaaaaa taaggggtac atgttctgat gcaaagacct attttaaaag 1888861 tgtgcaatta agctgtcttt aaagtttgaa aacacaaaag caatcaaaaa taccacaaca 1888921 aagaacaagt aaaaaacacc cttatacata ccaactctcc ctttaaaaat aactaacgtc 1888981 attttacagg attcgccgct attctacaac aaaatcaatg tgaattcagc aaaaaaaatt 1889041 catggcgaaa caagtcgtct tttgcgcttt cccggggaat atttaagagg aatatttcct 1889101 ctttagccgg gcaattctca catgcagttt ttcagtttct ttctctgata agcatgccgc 1889161 atcgctaagc gattgctctg ctacttgcaa tgcttttccg aattcttttt tcttatgctc 1889221 aaaatatttc gcgagctcta ttacagcagc gtatctgcac ttctggtttt gcgagcggga 1889281 cagcttttcc caaagcggca ctgcttcttc caagcggttt tgttttttgt acaggagcga 1889341 taaatccagc cgtgcactgt cctggtcctc aaacgatttt tctataagcc tttccaactg 1889401 cttgatcgct tggtccgttt ctttatgagc cataaaccat ttcgccatag cataggcttc 1889461 actgtgttct tttggcgcat gtgattctga aaggattttt ttagacatat ggatgtacaa 1889521 tgaaatgagt gataacacat ccatttcatt atgatgcagg acacctttta aaagatccgg 1889581 ctcttgcgcc ttgataaaat gaaagtaaag cattggcgcc aagtagcccg gtgtgtcttc 1889641 tagcctgcgg atgccgagct cctctttttc aaccgtgcca agagatacac ggtccatttt 1889701 gtgtttccac aggcgtctag ctccatgcaa aagatcaaag tggccaaact ccggaagctt 1889761 cggaagtctg tcacggatca aggtgtgcct tgttttcacc tgcggccaat caaaggcttt 1889821 gccgttgtag gtcacaagtg atgtaatgtc aacctcgctt aaaaagcttt ggtacaaggc 1889881 gacttcgttc cccggtttgg gcaaaagatg ctgtttgact gtcactcggt cttcatatac 1889941 tctcgcatgc ccaagcaaaa aaatggtatt cccagctcca cccccaagac cggttgtttc 1890001 tgtatcaaag aaaaagaggt tgtttttgtt ataccctttt gctgacaatg tatgcgacag 1890061 gccgctttga ttccacagtg tgatcacttc ctcaagctca gaaaagctgt ataacccatg 1890121 gcggtgagaa agcggatatt ctacttctct gatgaggcaa tattcatctt cgaagatgaa 1890181 aggcttcatg ccaaaagcct cccactcttc taaaaacggg atgtcatcaa agtggttttc 1890241 ttgtttgcct gcttctattt tttgttctcc ttcgtcgagc gccatgtgct ttttcatccg 1890301 ttggagtttc ccttttaatg acatatccgg cctccctcct tacgacattt gatccaacag 1890361 ctgcaaaatt ctttcctttg cttttatccc ttctatttcc gtacctatac aagacggaca 1890421 gccgtcatga caaggacaat gtgtaatcag ttgtttcgcc gcttcattaa tgtctgaaaa 1890481 acgtttaaag acttcctccg ccaaaccgat accgcccgga taatgatcat ataaaaatat 1890541 ggttggcaat ccggtatggg ctgctttaat ttgagaaaca acatgaacat catttcgatc 1890601 acacatgata tacacaggga caatatgctg cagcacattc gagatgccaa gaagcagctg 1890661 ttccagtgtc ttttccccga tgtcttcatc cgctgttttg atttcgagcc aagctgcact 1890721 tgtatgcagt tcttcttccg gcaaatgaat aggtccagac ccaatatttt caaaagtggt 1890781 catttttatt tttttaaaaa tggtcggcag ggcattgaca gtgacgtctc cgtagtgcaa 1890841 tgacgtacgg cttttttctt tcgttttatc gatttctaat accttcagct gaactgccag 1890901 gtttgcatcc gtataatatt cgacatcgac ttttctgaca tacgcctttt tatggtccca 1890961 atcgagcttc tcaacttgat actgaacgcc ttcatgcaaa taaatcgctt catcatgcaa 1891021 aagcgtcatc gcactaaaac ggtccatttc accgataatc cttacatttg caatatccga 1891081 ctgatcaact ataacgacat tttcctggga ggcggaacgc aaactgatgt ttgacgcagg 1891141 gaacgactca cttgcccaat ggtaccgttc gccgttgcgg tgaagaacag cctcttcctg 1891201 aagatactca agaatatcac tgacttccat ggctccaaat tcttcatcag ctctaaaagg 1891261 aagctcataa gccgcacact ttaagtggtc tactaaaata atcaaattct ccggattgat 1891321 tcttgcagat tccggcgaac gattaaagaa atattcagga tgccgcacaa tatattggtc 1891381 aatcggtgtt gaattggcta ccatgataat caaagattca ccgtgtcttc tgccggctcg 1891441 tcccgcctgc tgccaagcac ttgcaacact tccgggatac cccgtcatta cacacacttg 1891501 cagctggccg atatcaacac caagctctaa ggcattcgta ctgaccactc ctaaaatgtc 1891561 gccttctctc agtcctcttt cgatttctct tcgctctttc ggcagatagc ctccccgata 1891621 gcctctgatt gattttgttc caatctcttt tttcacaagc tcctgaatat ggcttaaaat 1891681 aatttccacc cgaactctgc ttctggcaaa aacaatggtc tgcactttgt ttttaaggaa 1891741 ctctttcgcc agttcattca cttctgcggt tgcgctcctt ctaatattca gcggtttgtt 1891801 cacaattggc ggattgtaaa acacaaaatg cttgcgtccg ctcggtgcgc cgttgtcatc 1891861 gaccagccgc atcggtttgc ctgtcagctg ctctcccaat tcctttgggt tggcaatcgt 1891921 tgcggaagta caaataaaaa ctggatcact tccataaaac cggcagatcc gcttcagccg 1891981 ccggatcaca tttgccacat ggctgccgaa cacacctcga tacgtatgaa gctcatcgat 1892041 gacgatatac ttaaggtttt caaacaaact gacccatttc gtatgatgcg gtagaatggc 1892101 agaatgcagc atatcggggt ttgtaatgac aatatgacct gcttttctca ccttttgtct 1892161 gattgccgga gacgtatccc cgtcatatgt aaagctttta atatcaatgc ccatttcatc 1892221 aataatttca tttagctcgc tcttttggtc ttgtgccagc gctttagtcg gaaataaata 1892281 taacgcccgg tttgtttcat cttgggcgat ggactgcagg actgggaggt tgtagcataa 1892341 cgtttttcct gatgctgttg gcgttacggt aacgatgctc tctccttttt gcacatattg 1892401 aaaagcggaa tattggtgag tatatagttc atcaatgccc cttttcgaaa gggccgcttt 1892461 gattctctcg tctatacttt cgggcatagg ccttgttttt gcttcccgag gctcaatttc 1892521 atgccaattc acaacgtttt catttccttt taaatcagaa atgagttcag tcagtgattt 1892581 ctttttcatt ctttacacct ctttgtcaag tacagtttac cgaatatttg tttgcatggc 1892641 taggtgcaaa ttttatacag ttgaataaaa aaagcaaggc atacgccctg cttatttcgc 1892701 ttttattgta aagagctttg attcgccttt acgagcagcc ttttcgcctg ccgataccat 1892761 tgatcctaca gcctcaccat tcattataac gattgggatg actgtgctgc tcgctttttc 1892821 ttttattaat tccaaatcac atgtaatcag cgggtcaccg accttcactt tatccccttc 1892881 tttaatgtgg gcagtaaatc cttctccgtt catattgact gtctccagcc cgacatgaat 1892941 taacagctca attcccgagc gagtccgaat gccaacggcg tgtttggtgt ggaaaatctg 1893001 aatgacttca ccttcagcgg gagaaacgat ttcaccgcta gaaggttcca ccgctattcc 1893061 ttctcccatc attttctgtg aaaaaacagg gtccggtaca tctgacaggt ccattactgt 1893121 accgtctgcc ggagaataaa taacctcttc tgtcaccttt tcctgaattt tgcccattcc 1893181 gaataatttt ttcagcaatg tattttctcc cttctcattc acttcaaccg ttatcccttc 1893241 attcaccact atttaaccac actttcaatt ttgcttcaat ttataacaac atctggcata 1893301 gacgcataat ctggttaaaa aaggcggtgg cgatattgga attccatgat gacaaaaaga 1893361 acgaactgca aaagaaagaa gaaatcataa cggaggcaat cgacactctt tttcaatcct 1893421 cagcgttcgg caaccttata aacggatttc agaacctaat caactcgagt ttaaaggatg 1893481 tgcagacgac catacatgtc agagaaagag atactgggct gtatatcgat attaccattc 1893541 cggcgacgtt tcgagatggc gagatcgtcg ttgatgttaa atcgaggtat ctccatgtaa 1893601 cactccaaga aaaacagaaa caccaaaatg aggctacctt tacaagcatg acaagaacgg 1893661 ttcagctgcc ttatgaagtt cgccaagaag atatggaaac gtcttggaac gagcagacaa 1893721 tgacactttt ctttccaaaa aataagcatg aatgaacgat tcattcatgc ttctatcatt 1893781 taaaaaagct ggtaaatccc tttattaaag atccgacctg attcattgca ctcattactt 1893841 gacctgtcgt atccatcatt ttattaaaat caaattgccc attggctttt ttgaactgcg 1893901 acataatgct ttgaaattgt gaaggctgct gttgattagg ccttgggata ggataagggt 1893961 tagaaaatac aggcggctgc ataggcatag gctggatcgg agcataaggc tgataataat 1894021 cctgctgtcc ataatgctgc tgaggcagtt gttgctctaa ataaccgggt gcagcctgct 1894081 gataatatcc ttgcatatgc tgaggataat aatagcccat ttgccgagga tagcttcgag 1894141 agctcccgtt cattgcgatt cccccctaaa cacaacatat ttctcttcta tatatgtatg 1894201 aatgacttct attgtttgtg tcacaagtga tgattagcat ttgtcaaatt gtgtcgaaag 1894261 tttaaatttt ttaaaaacag aaaaaagtcg aatcattatg gtaccatatt ttcaatacag 1894321 atgagagggg atgcaccata atgaacgtat catacttaag caaacgtttt gcagaaatga 1894381 agaaatatga aacagactgt atgaataaac tgatggactt tgccaagttc ctctatattc 1894441 aaggacatct cagcataact gagtttcgta acagtatgaa ggttctcgaa gcaaatggag 1894501 cagaaagccc ggcatatgag atgaattaac gtccggcccc ctataaaaac gaaaagaaga 1894561 cagcctttta ccggctgtct tctcttgcaa tttcatcctt tactgcgtgc aatgtataaa 1894621 ggactgactc agtgatgtcc ttgaatcgtt ttttatgaat atgatgaaca taagattgaa 1894681 ggaccaattc caggaaatta tcctttacgg cctcaatttg ctctttatgc acatattttg 1894741 gccggcggac ttttatcaat tcaagagcac cctctgccca gcgagcagcc agttcatcat 1894801 tctcttcaac tgcaggcttt atcgtctcaa aaaaatcata agaatgatta ctgttttttc 1894861 cttcctgata ccgatcagcg cctttttcag caacttcaat catttgctcg gtcatttcca 1894921 gcaaagtttg tgatagcaat atctttcacc tcaatgccta tcgtaccaaa tttcactcac 1894981 aaattcagcc gatgcggtat accttctcaa acgcatacct gtgttcaggc gattgataca 1895041 gctcatttat acaaatatga agatctatga tttcttcttc gagcacactt aggcgatcgt 1895101 tctccgtttc ccgcatctca gcctctaatg catttacaga atgattcagg ctttgctcag 1895161 ctcgcgttaa ttcatcttct atatcagaaa gcatacggag aatatctgtc ttgcatacat 1895221 aaccggacat tcgtgtacct ccctttcctt gtctctcccg gttaacattc tttgctctca 1895281 aggctctttc cttcctcatg acaaaactag aagcaaatcg ccaaacaaac aggtattcca 1895341 cgaaaagctg aagttttcga caaaaacacc cgcaaaaatt gtatgatcct cctcattaat 1895401 gcaaacgata cttgtgagga ggtgccgtat gaaaacaaga ccgaaaaaag ccggccagca 1895461 aaaaaagact gaatcaaagg caatcgattc tttagataaa aaattaggcg gcccgaaccg 1895521 cccttctacg taagaagcaa ggaatttcct tgcttcttta ttttttcagc cactgctcca 1895581 ccgcaaaaag cgcatgaagc tggcgctttt tatgtaaata ccagtctgtc aattcaatct 1895641 gcttcggcaa ttcctcgcgc ctaaagaacg ttttctttat ctttccatga aaccaatctg 1895701 ttttcgttcc gtctaatgag tggattaact cagggtagca tgtccttagc ataggagatg 1895761 ttctttttgt aatcccgatc atcttttcca tatcaaaacg ggaacctgtg tgcggcactg 1895821 tgtgcaaaaa gtgataaaaa gaggagaaca attctggctt gaacagcaat tgagacagct 1895881 gctttcccag ccttatcctt tcctccgcct ttgaaaagcg tttcactgaa atgccgtaaa 1895941 aaaacccatt tgaggaagga aaaataacgg tgttaaaatg aaaccagtca cttaaataaa 1896001 aaggaatcgt gtcaaaaaca ttctttttaa acgaaggatt ttgtataata ggtgtttgga 1896061 tagtgttttg ttcatttata atgagggcat acattagccg ctccgtattt cgctcatgcc 1896121 aaaaacgggt ccattcttcc gacataaatt gtgagacgcc aaacacatgc agcagatgaa 1896181 acagcggttt cccaactctt tttgaccagt ggtataaaag aagctgcgga taggcatccg 1896241 aaaaaataag ccagttcgct ctttcatagg ctaaaaagaa ccatttttgc tgtctctcac 1896301 ggagtccaag ctgaaacaga ctgcctttta agtcagtcat tgaccagccg gcattacgag 1896361 aaacgaaaga agccaaaagc gaccatttga tttccggatg acggtcgtaa aatgctttat 1896421 aagcatttgt tcttgaaatg ttatccgcgt ttttcatttt tgtctgccgc tcaatccggc 1896481 tcagaagctt tctgatggcc tgttgttctt gcacgttcat tcacttccgt catgattagt 1896541 ttaataagga ggatgagaaa gtgattcggt atcctaatgg aaaaacattt cagccgaaac 1896601 attcggtttc atcccaaaac agtcagaaaa gggccccgtc ttacagtaat cgcggaatga 1896661 ccctcgaaga tgacttaaac gaaacgaata agtattatct gacaaaccaa attgccgtta 1896721 tacacaaaaa gccgacacct gttcaaattg taaatgtcca ttatccaaaa agaagtgccg 1896781 cagtgattaa agaagcttac tttaaacaat catcgacaac agactacaat gggatttaca 1896841 aagggcggta tattgatttt gaggcgaaag aaacgaaaaa caagacctct ttccccctgc 1896901 agaattttca tgaccatcaa atcgagcata tgaagcaggt aaaggctcaa gacggtattt 1896961 gttttgttat tatatccgct ttcgaccagg tttatttttt ggaagccgat aagctgtttt 1897021 atttctggga cagaaaagaa aaaaacggca gaaaatcaat tcgaaaagat gagttggaag 1897081 aaacagctta tccgatttct cttggatacg cacccagaat tgattatatt agtattattg 1897141 aacagcttta tttttcgcca tcatctggtg cgaaaggttg attaacgaaa ggttgagatg 1897201 ttatgtcaga tcaatttaac agccgtgaag ctcgacgaaa agcgaacagc aaatcgagtc 1897261 cttcaccgaa aaaaggcaag aaacgaaaaa agggcggatt gtttaaaaag acccttttca 1897321 ctttactcat tctgtttgtt ttaggcgtag tcggcggtgc tgttacattt gccgtcatgg 1897381 tttctgatgc gccgtccctt gatgaaagca aattgaagac gccttattca tcaacgattt 1897441 atgataaaaa tggaaaagag atcgccgaag tcggcgccga aaaacggacc tacgtctcga 1897501 tagatgaaat tcccgatgtt gtaaaagaag cctttatcgc gacagaagac gctcgttttt 1897561 atgagcacca cgggattgac cctgtccgta tcggcggtgc attagttgcc aactttaaag 1897621 acggcttcgg ggctgaaggc ggaagtacga tcacccagca ggtcgtcaaa aactcccttc 1897681 tttcacatca gaagacgttg aaacggaagg tgcaggaagt atggctttcg attcagctgg 1897741 agcgcaatta ctctaaagat gaaattttag aaatgtattt aaaccggatt tatttttctc 1897801 ctagagcata cggaatcgga aaagcggcgg aagaattttt cggcgttact gatttaagca 1897861 aattgactgt cgaacaggct gcgacgcttg caggaatgcc gcagagccca acagcgtaca 1897921 acccggtcaa aaacccggat aaagcggaaa aacgacggaa catcgtactc agtctgatga 1897981 aaaagcaagg atttatttct gattctcaat ataacaaagc gaaaaaagtg gcagtgaaag 1898041 acgaaggcgt cgtgtcacag aaggaatatg aaaaagcaag tacaaacaaa tacagcgcat 1898101 ttgttgaaga ggttatgaag gaaattgatg aaaaatctga tgtcgatcca tctgctgacg 1898161 gattaaagat ctatacgaca ttagatacaa aagcacaaga taaactagat gaattaatgg 1898221 acggagacac cgtcggattt actgaaggca tgcagggcgg tgtgacgctt ctcgatacca 1898281 aaaacggaga agtccgagcg attggtgcgg gacgcaatca gcctgtcgga ggctttaact 1898341 atgctactca aactaaggca cagcctggtt cgaccataaa accgattttg gactacggac 1898401 cagttattga aaataagaaa tggtccacat acgaacaaat tgatgactca gcttatacgt 1898461 attctaacgg aaaaccgatt cgtgattggg accgcaaata tctagggcct atctcaatgc 1898521 gttacgctct ggcccaatca agaaatatac ctgctttaaa agcattccag gcagtcggta 1898581 aagatactgc tgtagacttt gcaaatggac tcgggcttgg tttaacaaaa gataatgtaa 1898641 cagaggccta ttctattggc ggtttcggtg ggaacgatgg tgtttctcct ctgacaatgg 1898701 caggtgcata cagcgcgttt ggaaataacg gaacgtataa tgaaccgcat tttgtaaaat 1898761 ctatcgaatt taacgatggc acgaagcttg acttaacacc aaaatcaaaa tcagccatga 1898821 gtgattatac tgcgtttatg attacagata tgctgaaaac agctgtgaag acaggtactg 1898881 gacagcttgc acaagtacct ggtgtagaag ttgcaggaaa aacaggaacg actaactttg 1898941 atgataatga agtcaaaagg tacaatatcg ctagcggtgg cgcccgagat tcttggttcg 1899001 ttggctacac accgcaatat acagctgccg tctggacggg aatgggagaa aacgaggctg 1899061 gaaagaaatc actttcagct gaagagcaaa aagttgcaaa gcgcatcttc gcccagctca 1899121 tcgccgatgt cgatgacgga agcggatcat ttgagaagcc tgacagcgta gtggaagcca 1899181 ccgtagaaaa aggttctaat ccggcaaaac tggcagggcc aaatacgcca agcgataaga 1899241 agctcacaga gtactttgtt aaaggcacag ctccttctac tgtttctaaa acatatgaga 1899301 aagaagaaaa agaggaaaca gctaaactgt ctggtttaaa cgtgaaatac gataaagaca 1899361 atcaatcttt aacgttaagc tggaattacg acggagatgc gacctttgct gttaagcaat 1899421 ctgttgacgg cggcagctac tcggaaattc aaaacagctc tgcaaaagag gcagttattt 1899481 cgggtgtgca gccaggatct gtatacaaat tcgaagtaac agccgtcagt gatgatggca 1899541 aaagtacagc ttccacatct tatgaggtgc caaaagctga agacgatgaa gataaaaaag 1899601 accagcaaca aacggatgat gaaaaacaag atgatgagaa gactcaggat gatacacaaa 1899661 ctgatgattc tcaaaaagat gacggtcaga cggatcaaga tcagacagat gattcaacaa 1899721 acgatcaaga caaaaaacaa gacaatacga acaccaatcc gtccgacaac aataaccaag 1899781 accaatcaaa cgataatgat aacgacaaca gtaacaacca ggatacgtcg gatggtgatt 1899841 cgaactctgg taagaatgat tcaacaggtt ctgacacgaa taaaaataaa acagacacat 1899901 ctaataaaac acaaacaaac tcatcatcca ttgaaaaaac aaattaaaca aaaaagccgt 1899961 cacctttggg gtgatggctt ttttggtaca caataaaaaa cctcccgttt taacaggagg 1900021 ttttatcgat tcatcgcatg atatttataa aaatgctttt tcatttcggt aatcagctca 1900081 tcaagctgaa taaagcaatg gtattgggtc ggcttaagaa gaataaattc cactcgttca 1900141 gcccaattaa tcggctttgc gggatatgat ttctccctca gttcttgcca atcgagcgat 1900201 ttcaccggct cacctgctgt ccaatgtaac gaagccagca aacacacaat gccctttaac 1900261 atttcgtttt ggtcacatct cgattttcgt gtttgaaaga ctgggagaag tgatgctttg 1900321 atgtcatccc acacttcaaa taaaagcgga acgtatttcc cgctgtcctc ccatggcaaa 1900381 tcgccttgta attccgtgca gaaatcaaaa tacacgggat tggtctgcaa ggttttcttc 1900441 atatccgagg aactcttctg gccaagactg cgcaagtatt gctcatagga agccaacact 1900501 tcttttgctt gcgtcatcgt ttcaccagtc cttttttatc cctcttctgc ccttctctgc 1900561 acaaagaaag cagcggacac tccgcacagc gcggagattg ggctttacag tgatatctgc 1900621 cgaagaaaat aagccggtga tgcgtaacgg accaatcttc tttgggaacc ttgcgcatca 1900681 gcgtcttttc aacttccaga accgagtcct tccaccggca aatgcccaat cgtttgctga 1900741 ctctctccac atgggtatct acggctatgg ccggcacgcc aaacgcaacg gataccacta 1900801 cgtttgcggt ctttctcccg acccctggca gtttgacaag ctcatcgcgg tctctcggca 1900861 cttctccgcc gtaatcttca ataatcattt tactcagctt ttgaatattt ttcgctttat 1900921 tacgatataa accgattgat ttaatatcct gctgaagctc ttccagcgga acagccaaat 1900981 agtcttccgg ccgtttatat ttttggaata atgttttggt cactctgttt acaagtgcat 1901041 ctgtacattg cgcagataaa gcaacagcca ccactaattc aaaaggattg gaatgaacca 1901101 gttcacactc cgcatgagga aacatgtcac ctatcttgtc taaacagaat tcaatttgtt 1901161 ttagatttaa cacgattgtc accttttcac tttattgttc aagccaattg taaaaaggaa 1901221 cctgcctttt atactctttt tgcggttcat tctgctttgc ttgtacacgc cggaattttt 1901281 ggctgtgtat ttttgcctgc tccacagttt taagcccatt tttcttccat tcaaacaaaa 1901341 tccggtcaat gtagcggaaa ctgagttttc ctgatagtac agcctctttt aacgcgtgtt 1901401 tgatcagttg tgcgtcatgc tgatcctggt cctgccagat cgccagcgtt tcacactcca 1901461 aaggcgataa cggtcttgcg aactcttcct caaaaatggt ataaaggctt ttttgttccc 1901521 cttctgcttt tctttcctgt gtttgattct gtgcaagctg aatatactcg tacagcttgc 1901581 cccataaagg ctgaagagaa tatttctcaa atttgatgcc gttttgatcc tcgcattctt 1901641 caataaacag aaagcctttt tgaataaaca tccgcaatct gtttgtacat tcttcaacag 1901701 aaattgacat accttcctgc agctgattcg gtgtaggaaa atatgatcct ttttctaaat 1901761 gcattttaat ttttaacagc agaataagtt ctgtttcatt aagcccaagc tgtttataat 1901821 gcgtgagcag aagattgggg atggttgatg ttccctgctc ctgcatatca ataaattgct 1901881 gttttttcat cgtcacacct cttactgtaa aggattgtga ttgccccttt actgtaaaaa 1901941 gtctcccttg caggagactc ttttttgttt catttgaatg tattacggat acagacggtt 1902001 taacagtctt gggaacggaa tcgtttcacg aacgtgaggc gctccgctga tccaagctac 1902061 tgtccgctct aatccaaggc cgaagccgga atgaggaact gatccatatt ttctaagttc 1902121 agcataccat ttataagcgt cagaatccag tccatgttct ttaagacgcg attccaaaag 1902181 ttccatatcg tgaatccgtt cagacccgcc gatgatttct ccatagcctt ccggcgcaat 1902241 caagtcagcg caaagcacaa cgtcctcacg gtcagaagcc ggctgcatat agaacggttt 1902301 taaggacgtc ggatagcgag tgatgaatac cggtttgtca taatgttcag caatcgctgt 1902361 ttcatgaggc gctccgaaat catctcccca ctcgatatcg tcaaagcctt tttctttcag 1902421 aaattcaatc gcttcatcat acgtaattct tgggaacggg gctttgattt gctcaagttt 1902481 tgacgtgtct cttcccaatg tgtttagttc aattttgcaa tttttaagaa ctgattgcac 1902541 gatgaaagaa acgtaatttt cctgtacttg aaggttttct tcaaattcta caaacgccat 1902601 ttccggttcg atcatccaga attcgattaa gtgacgcttt gttttagact tttccgctct 1902661 gaatgtcggt ccgaaagaga atacttttcc taaagccatt gccgcagctt ccatgtagag 1902721 ctgtccgctt tgagacagat atgcatcttc atcaaagtac tttgtcgcaa agagttctgt 1902781 tgttccttca ggtgcgcttc cagtcaaaat cggcggatcc acttttacga agccttcgtt 1902841 attaaagaat tcgtaagtcg cgcgaatgat ttcattacgg attttcatga tcgcatgctg 1902901 gcgctttgaa cgcagccata aatgtctgtg atccatcaaa aattccgttc cgtgttcttt 1902961 tggtgtaatt ggataatcgg tcgcttcgtg aatgacttca atatctgtca cagcaagttc 1903021 atatccaagc ggagaacgct cgtcctcttt gacaatccct tttatataga gcgacgtttc 1903081 ctgcgtcact gatttagctg tttggaaaat gctttcttcc acttccgctt ttactacgac 1903141 accctgaata aaaccggtac cgtcccgaag ctgtaaaaac gcaattttcc cgcttgaacg 1903201 cttattagcg acccaagctc cgatcgttac ttcctcacct acgtgcttgt acacttggtt 1903261 gattgttgtt ttcaacatat ttccctccaa aacaagaaag acattcggaa gctcattgcc 1903321 ccgcgaactc ttttatcatc actttattat acccgctctt aactaaccgg gtcaatgcag 1903381 ataaaaagcg gcttttctgt cagccgcttt ttgatctgtt agctatgttt ttctacaaaa 1903441 cgcttgattc tttcaatggc ttcttcaaga agatctaacg atgttgcata agaaagacgg 1903501 acattctcag gagagccaaa tccggatcct ggaacaatcg caactttttc ctcctcgaga 1903561 agcgctttaa caaattcatc tacatctttg aaaccgcaag attgagctgc ctcttttgca 1903621 tttgggaaca agtaaaaagc accttccggc ttcacgcagc tgaaccctgg gatttctatg 1903681 agctttgcat agatcgtatt taatctatgt tcaaatgctt ctctcatttc ttccaatggc 1903741 tcagaaggcc cgttataagc agcaatcgct ccgtattgtg cgattgatgt cgggtttgac 1903801 gtgctgtggc ttgcaaggtt cgtcatcgct ttaataatgt cttcagagcc tgccgcataa 1903861 ccgattctcc agcctgtcat gctgtgggac ttcgatacgc cgtttataat gaccgtttgc 1903921 tctttcagtc tgtctgacag ctgtgcaatg gaaacatgtt tctttccgcc gtatgtaagt 1903981 ttttcataaa tttcatctga cacaatcaag atatcatgtt caaggcacac ttcaccgagc 1904041 gcagatagtt cttcttccgt atacatgaca ccagtcgggt tgcttggaga gttaataacg 1904101 attgcttttg ttttttccgt aattgcattt ttcagctgct caggcgaaat tttgaagtga 1904161 ttttcctcaa gcccttctac ataaacaggc tttccgccag cgagtttcac ctgctccggg 1904221 tagcttaccc agtaaggcgt tggaataata acttcatctt cttcatccaa aatcacttgg 1904281 aaaagggtat acagagcatg tttggcacca gtgcagacaa taatttgaga cggtttgtat 1904341 tcaatattct ggtcgcgttt aaatttctct gcaatgctgt ttttcagttc agccaaacca 1904401 ccggaaggcg tgtatttcgt atggccctcg ttcatcgaac gcacagcggc atcaataata 1904461 tgctgcggtg tattgaagtc aggctcgcct gctcctaagc cgatgacatc atggcctgcg 1904521 gctttcagtt ctttcgcttt cgctgtgatt gccagtgtgg ttgatggtgt taatgcggat 1904581 actctttttg ccagtttcaa cttgaactcc ccctaattcg tcttaaggcg tgatattttt 1904641 gagaatcttt ccagttgtaa agtccacata acttaaactg tattgccctt ctttgtctaa 1904701 gtacgtcact tcccaaagca ggacgtttcc ttctcttgcc agatgaacct ctttttgctt 1904761 tgaaaccagc ccttcatcct ttatgatttt cgccgctttg tcttcagaga ttccctcttt 1904821 cgcttctttt gagagaattt ttgctttttt atcagcagga acccagacat ataatgcagt 1904881 gcctttttta tccgttccct ttacaacata atatttttct tttccgacaa atgtttcgac 1904941 ttgatcaaca tgggcgagat cggtttcttt tttagcttca gcagctgctg cttcgtgccc 1905001 ctcttccttt tgtgccatgg ctgatttata aatgcttgcc gagacaagaa gtactgctaa 1905061 aaaaataata ccaaaaatga cggtaaatat taatgctttt tttctcatct tctcacctac 1905121 gtacgataaa tggtaaaaac ggcttggttt ttgttttctt catccagcgc aaggccgaac 1905181 atcagattgt ctcttttcag tgtacgattc aatgtgtcca caattttata cagatcatca 1905241 gaatgctcta cattaattgt tgaaagaatt tcgattttac tttccatttt ttcatcctcc 1905301 agtttgaaca aatattgtta gtcatactcc atttcaggac acgccatact agtatcacag 1905361 agcgggaaat ccgcttttaa ataaaacacc atcctactcc cacaccgcaa aagccgcttt 1905421 atgcggcttt tattcttttt cccctgcaac ataagcttca agctcgctgt cagtcatttc 1905481 ggatactgag gttgtcggca aggcatcaag aaacagccgg ccgtaaccag cggttttaat 1905541 ccgtctgtcc aatataataa tcgttccctt gtctcccgca gaacgcagca agcgtccgat 1905601 tccttgcctg aaggtcagca cagcttccgg taatgacact gtttgaaacg gattctttcc 1905661 ttttttgcgg gcaagctcac attttgcagc atgaagcggg tgatcagggg accggaatgg 1905721 gagcctcacg atcattactg tcgtcagctc atcaccaggg aaatcaacgc cttcccaaaa 1905781 atgatttgtt ccgagcagga tcgcctgatt ggatgtttta aaagtcttca tcagtttgcc 1905841 gggacttccg cctgtaatcc cttgtgccaa gagctgaatg ccggaagcac tcatgttatg 1905901 cttaagctcc tggtgaacct ttttcagcat atcatgggat gtaaacagca caaggatttt 1905961 aggctgtttt tcctttgcca tcagttcgat ataacgggct gtatcctgta taaattcagg 1906021 ttgccctgta tcctgaattg atttcatttc ttttggaatc atcacctgca tacgctcatc 1906081 gtaagaaaag ggtgactcaa ttctcattgt ccgcgggaaa aagtcactca gtcccagtcg 1906141 ttcaatcata aattgaaaag aaccttcgac tgtaagagtt gcagatgtca gcaccacact 1906201 atttttgcgc gcgaaaaact gatcagccag aagttcacca ggttcaagag gctgtgcgta 1906261 aatggccact gcatttttcg caccctttgc atctatttca atccaaaccg cttcatcgtc 1906321 atcagagcca aagaagagct tctgcaacgt ctgacagtaa tgctgcaagc ctttcatgct 1906381 tctttggtat tcatcggcta aaaagacggt tttgctcttc atgcccttca aatgtttttc 1906441 cataagggat gactgcgcct caaaaagctg ctgcaaatgt gtcagcatgg aacaaagcct 1906501 ctccgcacca tctgttaaga tcgaccagct tttatcctgg ctttctttgt tcaccttaaa 1906561 cactagacgg tttaagtctt ctttaggttt tcttcgtttg acaaaagaat gtacagagct 1906621 aaagaaagca tcactttctg cttgaacgtg ctgaagccac tcttccaatt cgaaaaatga 1906681 atcaaccggc aggctgtttc gctggaatag ctgtctcatc ttttttagaa gtccctgctc 1906741 cttcagagtg ccgattctgc tcaatttcgt atgcaattct atgtacgtgg ctcttttccc 1906801 taaatgttcg cttgccgcac gttcaaaatg gtgtgcttca tcaataataa atgtgccgct 1906861 ttcgggaagc ctttttttat ggctgccttc atcggtcagc aaaagagaat gattggtgat 1906921 caccaaatcg gaacgcatag caatctgttt ggcccgctcg taaaaaccga tcacatgctc 1906981 actgcgactt cttttatagg agtcatcgtc ataagccaat ctgtcccaca gcaattttcc 1907041 gcctgaaggc aaattcagtt ccgctacatc tcctgtattt gtctctgtca gccaaacaag 1907101 aagctgtgcc tttgtcagta cggcatcata attatcatct tcttcatgaa gcacctgctc 1907161 aaatttatac aggcataaat aatgcgattg cccttttaaa atcgccgctg ttaccggaaa 1907221 tggaaacaga tcttggacaa tcggcaaatc ctttgtgaga atctgctgct gtaaaagcgt 1907281 cgaatacgtg ctgattatga ccggcttttt tgatttcttg gcaaaaagcg cagccggaat 1907341 aagatagcca atcgtttttc cgatgcctgg aggagcttca atcagcgcat gctcacgatt 1907401 ggcaaacgca tcagccacct ctctcatcat catcatttgg ccgtctcttt tttcataccc 1907461 aggcattaac tctgacagcg ctttttcatt tcccgcttcc cagctttcga tctcaaatga 1907521 gaagttctcg tcctcattta tacgaacatc gatagcttca ggttctctga cagaaaacga 1907581 agaaaagcgc gtatagcccg gtatctcggt atgtctgttt tcattaatga acatatccaa 1907641 caaatgcgtc agatcactga tgaaatgctg cgaaagcctt cttaactgct ttaatgtcgg 1907701 ataaggaagc tgccgcagct tttcaaggat ttccaaaaaa ataagccctg tcacttcagc 1907761 atcgctgtca gcccggtgcg gctgatcatg ccgcagctga agctcctcgc ttaattccgt 1907821 cagcttatac ccttcaaatc ccggaaaaac aatgcgtgag agctcgacag tatcaagcac 1907881 ttcacaatct gggagctgaa agcccgcctt atgtagctca tacttgacaa atccaaggtc 1907941 aaaatggata ttgtgggcga caaaataagc gccgtcaagc aattggaata cttcttcagc 1908001 aactgcttca aatggctgtt cattctcgac catttgatta gagattccag taagctgctc 1908061 aataaaagca gggattgatt tatttggatt aatgtatttt gaaaaccgct cagtaatttg 1908121 tccattttcg attacaaccg ctgcgatttg tatgatttta tcgcctttct tcggcgaatt 1908181 ccctgttgtc tctacatcta taacaacgaa ccgttgctta ttcattaaaa tggacacctc 1908241 aattcttgca tacgacaaaa gtgtaacacg ttttgtacgg aaatggagcg gcaaaaccgt 1908301 tttactctca aaatcttaaa agaaaacccc cgataaaggg ggcttttctt ctacaaaatt 1908361 gtacgggctg gttcgttccc cagcatttgt tcaattttgt tttgatcatt cagaacagcc 1908421 actttcggct catggcttgc cgcttcttga tcagacatca ttttgtagga aataataatg 1908481 accttatctc cttcctgcac aaggcgtgcg gctgcaccgt ttaagcatat gacgccgctt 1908541 ccccgtttac caggaataat atacgtttca agacgtgctc cattattatt attcacaatt 1908601 tgtacttttt cattaggaag cattcccaca gcatcaatga gatcttcatc aattgtaatg 1908661 cttcccacat agttcaggtt tgcttccgta acagttgccc tgtgaagttt gccgctcatc 1908721 attgttcgat acatattata ttctctccat ttctcgaata tcaataatga tattatctat 1908781 taaacgcgct tttgaaaaag caactgcaac agcgagaatc atctttccag caatttcatt 1908841 cacaggctcg agttccggat aggaataaag ctctacatag tctatggttc cgctagtcgt 1908901 ttcaatgata tcttttgcag cttttatcac cgcttcagga tctctttcac cggcttggac 1908961 aagttccgca cttgtttgaa gggcccgata cagcttaggc gcttcttttc tttcctcagc 1909021 tgttaagtat acattgcgag agcttttggc taagccgtct tcctctctga ccgtatcgac 1909081 aggaaccaat tcaatatcca tgaagaagtc gctgattaac ccatcaacaa cagctacctg 1909141 ctgcgcatct tttaaaccga aataggcacg agtcggcttg actagattga aaagcttcgt 1909201 cagtacgatc gcgaccccgt caaaatgtcc ttctcttgag cgcccgcata acacgtctgt 1909261 gcgtctttct acatgaatcg tgacattctt ttcaccggga tacatatcat gagcatctgg 1909321 cgtaaaaaga atatcgactc cggcgttttc tgcaagagct gcatcccgct caatatcgcg 1909381 cggatatgct tcaaaatctt cattagggcc gaattgtgca ggattcacaa aaatactcat 1909441 aataacggcg tcgttttctt gtcttgcttt gtctgctaag gttaaatgcc cctcatgcag 1909501 aaaccccatc gtcggaacaa atccgattga cttgccctct gaatggtatt gttttatggc 1909561 ttctttcagc tgtgaaatat cagtaatctg tctcatctta ttttcccccg tacaagccgt 1909621 caagcactgt ctggttcatt tgaaaggaat gcttttgttc agggaaagca cgatgtctta 1909681 catcctgaac atatccgctg attgctgttt cgatggtttc atcaatgcgc gtatattgct 1909741 ttacaaattt aggtgttctc tcaacaccgt ggccgataat atcatgataa acgagaactt 1909801 gtccgtccgc tttcacacca gccccgattc caatgaccgg tatgcttagc gtctcggcaa 1909861 ttttggctgt gagttctgcc ggcacacatt ccagcacaag catcatagct cctgcttctt 1909921 cgcattttat actgtcttct attaattttt tggcgctttg ttcgtctttg ccctgtactt 1909981 tatagccgcc cagtacgccg actgactgcg gtgtcaaacc taagtgactg actactggaa 1910041 tgcctccaag cgtcaatgcg cgaatggatt caaacacgcc ttctccgccc tcaagcttca 1910101 gtgcgtcagc tccgctttcc tgaacgatag ccgctgcatt tttcagcgta tcttccttag 1910161 acaggtgata agacataaac ggcatatctg tcacaataaa ggtattcggc gcaccccttt 1910221 taacggcttt tgtatgatgg atcatgtccg caactgtcac accgacagtt gaatcaaggc 1910281 cgaggacgac cattccaagt gaatcaccga ctaaaatcat gtcaactccc gcttgttcag 1910341 caagtttagc tgccggataa tcataagcgg tcagcatgac aatcggttct tcagactcct 1910401 tcatttttag aaaatccagt tttgttttca tgttttctcc tcctcatgtt tagaggagat 1910461 gatctgccgt tttcttctgc aagccaaaaa accttccgtt acaacgagaa ggattcttca 1910521 ctttctaaag ttcggcgagt ttcatccctc tgtcccagtc cttttttgga tcaaggcaga 1910581 ctgctgcaat gtctatctat tttaataata ggtgcagttc gcaggcgata ctgcccaatg 1910641 gaagtatacc aaaatcaacg ggcttgtacc aacacattag cccaattcga tatcggcaga 1910701 atagattttt ttaatgcctt cgttcgtttc taaaagcaga acgccttcat catctatacc 1910761 taacgcctta ccgtaaaagg ttccgtttaa cgttctggct ctcatattag tgccaatacc 1910821 gagcgcatag ctttcccata aaagcttaat cggcgtaaat ccgtgcgtca tataatcccg 1910881 gtaccgtttc tcaaagcata gtaaaatatg ctggatgacg ccggcccgat caattttttc 1910941 cccagcagct tggctgaggc ttgtcgcgat gtccttcaat tcatctggaa aatcattagg 1911001 ctgctggtta acgttaatgc cgatcccaat gatcactgaa cgtacgcggt cttcttcagc 1911061 ctgcatttcc gttaggatac cgactgtttt ttttccgtta atcaaaatat catttggcca 1911121 tttaatatcc gtttggatgc ctgctgcctc ttctattccc tgcacaacag ctactgcagc 1911181 aagcagagtc agctgcggtg ttttttggag cggaatgtca ggccgcaaaa tcaggctcat 1911241 ccaaacaccg tttccttctt gagaatgcca taccctagac attcggcccc ttccggctgt 1911301 ttgtttgtca gccaccacaa gggtgccttc cggtgcgtta ttattcgcga gctcatgagc 1911361 cgttttttgc gtgcttgaaa gaacgtcatg gtaaataaga tgctggccca tcacttccgt 1911421 ttttaatcca aaacgaattt cgctttcact gagttttccg ggttttttga tgagccgata 1911481 tccttttctt ctaacggctt ctacttcata accctctttc cgaagctctt caatatgctt 1911541 ccacacagca gttcttgaac agccgagagc atcactgatt ttttggccgg aaataaattc 1911601 attgccggcc tgagaaaata attcaataag gtcttttctt aatgttgacc gcatgtcttc 1911661 agccactcct ctatgtgttt cttttgattg gagagcttcc ctgtcacaac agcctgctcg 1911721 atccactgta attcttctga cacccatttt ccggccggcc ggtttcgaag cgcaagcaag 1911781 tccttacccg tgatatcaag atccttaagg cttttgatcg gcaggttttg ataagcgtac 1911841 tgaatgtcct tcagtttctt ttcatccagt ttttcgtttt gccgaagctg cgatattttg 1911901 gccgctgaga gcagtgcttt tttcccagct ctgtacattg tcattgcgtc aaggctctgg 1911961 ccaaacgtat cggcaatgtg aatggcttcc ttgatcactt ttcccgggag cttccaggct 1912021 ttcaggaaaa ggggcgcgtc tttcaaaact atgccaaggt taattaaaag agcagcccaa 1912081 agctcctcac gggatgttaa agagaagaat ggaaactcac tcgttgaaat caggttttct 1912141 cgtttatgat aaaaaccagg aagctcttca tacaatctcg tttgaatgag tgtttgaagc 1912201 gcctggcgag aagctcttcc ctgcagcaat ttctcaaact ctatagtttt tcgttcgact 1912261 gaaacatggg agaggagtga tttttctttc gcaatggctt cttctgtttc cggtgaaagc 1912321 gtaaagccaa gctggctcat aaagcgtacg gctctcagca tacgaagcgc atcctcttga 1912381 aatctatcct caggctttcc aacggttcga atcactttct gatcaatatc tttcttgccg 1912441 ccaaaataat caagcacctt cccgtccgct gtcatggcca tcgcattgat cgttaaatct 1912501 ctgcgtttta gatcctcttc taatgatgag ataaattgca cttctgacgg tcttctgaaa 1912561 tcaacataat cagattcagt ccggaatgtc gtgacttcat aggtttcatc ctcccagagc 1912621 acaataatgg tcccgtgctc tttgcctaca tcaacagtcc gctgaaacag ccgttctact 1912681 tgatcaggtg ccgcatctgt cgcgatatcg acatctccga tcgttcgttt catatagctg 1912741 tcacgaactg cgcccccgac aaaataagcc tgatggcccg cttcgattaa gatgcggagc 1912801 acgggaagtg ctttgataaa aactttttcc atgtgatcac tccggttctg ctaaatcggc 1912861 ataaatctgt tcatactggc tgacaatttt tttagaagaa aattcatttt caagcatctc 1912921 tattgccgcc tttgtaaaac gattgcttag ctgttcatct tctaaaatgc tcatcgcgcg 1912981 ggctgttgcg gccgtaacat caccgacatc caccaaaaat ccgctcacat tgttttttat 1913041 aacctcaggg ataccgccaa tgtttgttcc aatacaaggc actccgcaag ccatcgcttc 1913101 aagcaggaca aggccaaagc tttctttttc agatagcagc agcttcaaat cgctaataga 1913161 ataaagatct tcaacacggt cttgatttcc aagcattaag acttggtctt ccaagccata 1913221 ttttctgata agctcgcagg ctgtcgattt ctccggaccg tctccgacta aaagcagctt 1913281 cgctttcgtt ttgccagcga tattgcggaa cacacggatg acatcctgca cgcgtttaac 1913341 ttttctgaag ttggacacat ggatgacgac tttttcatct ggtaaaattc catgtttctc 1913401 tttaattgcc gctgtgtttt tcttcagata cacgcgctcg tctataaagt tataaatcgt 1913461 ttcaattttt ttctccggtt taattaaatc gtatgtttca gccgcaagcg ctgaggagac 1913521 ggccgtcacc ctgtctgatg actcaatagc aaaacggatc agatctttta gagacggatc 1913581 ataacctaac accgtgatat ccgtgccatg caaagtggta acaatgccga tattgcgttt 1913641 cagcatttgt tttgcaagat aggcgcaaac ggcatgcggg agagcatagt gagcatggat 1913701 aatgtctaaa ttctcccgtt ccgccacctc agcgattttg cttgccaatg tcaaatcata 1913761 cggaggatac ttaaaaacag catattgatt aacctcaact tcatgaaaat gaatattggg 1913821 atgatatgta ttcagtctaa acggaatgct tgatgtgatg aaatggattt catgtccctt 1913881 ttcagcaagc tgcttcccca gttctgtcgc aatgatacct gagcctccaa cgctcggata 1913941 gcatgtgatt cctattttta gttttctcat tgttcgcccc caagcacatc atgatcaagc 1914001 atcagcatcc gtttggaaaa gaaaccttcg gcatactcca cgcccgcttc tttaccgtaa 1914061 agcttttctc tcgcttcaac gatttcaata tacccattcg tcagaggagt agaaacggaa 1914121 tcctttgacg ggataaactg gcttttgtag gcgttgaggc tttgtttctt tgcctctatt 1914181 gtatccgaga tatcaataac aaaatccggc tgatgaaaac catttatcat ataatagtaa 1914241 accttgctga ctttatgcgc cggaaggctt ttttcgtctt tatatttatg gattccggcg 1914301 gaaaagatcg cttcttccac cagtgcagcc gcattgccgt gatccggatg gcgatccttt 1914361 ttatacggca taaaaaccgc ttttggccga cagattctga tgacagtgac aattgaccga 1914421 attgcctgat cactcattat taggccgcgg tctggaagcg ttagctgaat tcttttatct 1914481 gcgcctaata tgcgggctgc ttcagctgct tcttctttac gcaaactgac cgtaccgtta 1914541 gaagagagtt ccgcttctgt caaatcgcat atcattactt ttttttcctg tttgacaaac 1914601 ttcgctattg tgccgcccat tccgatctcg acatcatcac tgtgggcgcc aaaagcaaga 1914661 acgtcagcat tatacattcg gctcttctcc ccgaagaagg tcacggaatt cgaaaacacc 1914721 ttcatcaagt gtgcgcacaa gaatttccgc agtacccata tttgtggcga gcggaatgga 1914781 atacacatca cataaacgga ttaatgccga gacatccggt tcatgcggct gcgcggtcag 1914841 cgggtcgcgc aaaaaaatga caagatcgag tgcattggca gcgatcagtg caccgatttg 1914901 ctggtctccc cctaaagggc cggattgaaa acgttcaatt tgaagacctg tcgcctcatg 1914961 aattttcaac cctgtggttc cggttgcgta tagatcatga ttctttaaaa tatcccgata 1915021 ggcagtcgta aattgaacca tatcctgttt tttcttgtca tgcgcgatca aagcaatttt 1915081 cattgtttat ccccccgtct aatcaatgat attttctaaa ccatacacaa gctgatcaat 1915141 cttcatgact tgttcgactg acagtttaac gcctgacatg aaagaagcac ggttataaga 1915201 atcatggcgt atctgaagcg tttggccatc catgccgaac atgacctcct gatgcgcgat 1915261 cagtcccgga agacggacgc tgtgcaagcg aataccgttt tgctccgctc ctcttgctcc 1915321 tgggagaatt tctttttcat ccggatgtcc ttgctgcttt tctttacgga cttctgaaat 1915381 catttccgct gttttaagcg cagttccgct tggtgcgtca agcttctggt catgatgaag 1915441 ctcaataatc tcaacatcct caaaatagtt ggcagccatt tttgaaaatt tcatcatcag 1915501 tatcgcaccg agcgcaaaat ttggcgcgat gatggctccg atcccttttt cttctgttaa 1915561 agatgtgagc tcttttaaat cagcttctga gaaaccggtt gttccgacaa ctggacggac 1915621 tccgtgctct aatgcaattt ttgtatgtac ttttccgatt tcgggcgttg ttaaatcaat 1915681 caagacatcc ggttgtgttt ctgtaaaaca ggcatggata tctgtgtaaa tgaaagcatc 1915741 tgactcaaca ggcatcacat cagataattt ttgctgatcg tatgtatggt ctatggcccc 1915801 tacaaggtca aaatgtggtg ttcgttctgc caatttaaca gcttcctgcc ccattcttcc 1915861 acgcggtccc gcaatgacta atttaattgt ttcgtttgac atcttgatct cctctacttt 1915921 ccttcttctt ttctggtcca gcgatcttta tctcttgtat taaatttatg catgactcgg 1915981 tcgtgagctt cctctaaaga gatatcaaga gagttggcta aacaaaccaa tacaaatagc 1916041 acatcgccta tttcctcttc catgctttta tcatcttcag tcgctttttt tggtttttct 1916101 ccataacggt gattcacttc tctggcaagc tcgcccagtt cttcagtcag cctcgccatc 1916161 atggccagcg ggctaaaata tccttcttta aattggccta tgtaacggtc tacttcagcc 1916221 tgtatgtctt tcattgtttt atcactcact gaacgaaacc tcctatcatc ctcttacatg 1916281 ttagctaatt cagatacgtt tgacaaatgt ttaagcacgt ttgctgtttt ctttttcatc 1916341 cactataata taaacgctat ctaatggaag gaaaaggggt tttgtgtgat gcttggagaa 1916401 attagattaa aaaacatatt ttttatttta atcggagcgg caattttttc atttggcttg 1916461 gttcatttca atatgcagaa caatctggct gagggcggtt ttacaggtat tacacttttg 1916521 ctttatgccc ttttccacat cagcccctct atatcgaacc tggtgttgaa cattccgatt 1916581 ttttttattg gctggcgttt gctcggcagg acaatgtttg tttataccct tgtcggcact 1916641 gtagccttgt ctttgttcct cagcatcttt cagcgatatg aaatccatat gccccttcag 1916701 cacgacttag cgctcgccgc tttatttgcc ggcgtattca tcggagccgg actgggtatt 1916761 atttttaagt tcggcggtac gacaggcggt gttgatatca tcgcacgttt agtgaataag 1916821 tattttggga ttccgatggg cagaacgatg tttgctttcg atgcctgcgt catcattttg 1916881 tctttgctta cttatctctc ctataaagaa gcgatgtata cgctggtagc tgtatttgta 1916941 gcggcaagat taatcgattt tattcaggaa ggcggatacg ctgctaaagg cgctacgatc 1917001 atctcttcga aaaacgacct gattcagaaa aagattcttg aagaaatgga acggggcgtc 1917061 accattttga aaggacaagg ttcctacaca aaagaggata tagatgtact ttattgtgtg 1917121 gtgccgaaaa atgaattggt gatgctgaaa agcgtgatta actccattga tccccatgcc 1917181 tttgtagcgg taagcgatgt tcacgatgtg ctcggagaag gatttacgct tgatgaaaat 1917241 aaaaatccgc ttccgcgctg acatgtaata gaaaaaaggc ggctgaccgc cgcccctcat 1917301 ccttatttag ggtagtccct ttttttcagc ttgttttttt ccgccttgta ctttctgtaa 1917361 ccgacatagg taagagcagt aatgatgata ctgccggttg taatgatcac ccagagtaaa 1917421 gacggatcgg catcatcctc ctccaccctg tcaaacacat ttttcaggtc atgctgaaga 1917481 agggaaagcc gttcaagctt cgtgctctct gtcatttgct gaaattcctc ttgctcaata 1917541 acatctatat gttttccgac tgtttcaagc tgatcctctg atacatcgat tgtaagactg 1917601 gggtaaatca agtcatataa actgataaat tcattccatt tttcatgaaa gcttgtgctt 1917661 ccattctttt ggacatctcg cttcagttca gtaaaagctt ccataatcgg tttttccagt 1917721 gagccccaaa gcgggtcaga ccgattgtca accgcatcca tcagcattct gaactgcgcg 1917781 gctgctctga gtttttgtgt gtctgatgta tcagcttgct ttaaactccg aaccatatca 1917841 ttatagccca atgtgatttg acgaatttgg gctcccgtta gcatggggtc ttgctgtttt 1917901 ttctcagcgg attttaatgt tttttcaaaa tactccaaga cttgaagcgc ctcttcatat 1917961 ttcgcctgtc gggtcatttg aaagactgta tcggataaat cattcaattc ctcgaggctt 1918021 ccccgctctg cagccttggc atttccatta taaaaaataa gtgcaatcaa caaacagatc 1918081 gtcagctttc gtttcatgca ggtccctccc actctctctc cttacagaat atgaagaaag 1918141 ggacaaggat agaccaacat tgtctttaca tcagctcaag cttcgtttgc ttttttgaga 1918201 ccacaagaaa gtaagcaagc gcgattgaaa agatacttag ccaaaatgtt ccgtatccta 1918261 tttcagtcat ataatcagaa agcatagagt attgcggcat catatcaaac aagtagtcaa 1918321 tgacatcgtt atgcagtgtc cagactgcag caattgcaag atgccaaaat gaaaaacgaa 1918381 aatacggact gtataatacg ccttgaactg ccattgcaaa atgcgaagca attagcatgt 1918441 agccctccca cggcaagtca ccagttactg caagcacaag aaaattcata gccaccgccc 1918501 ataggccata ctttacgagg gtaactagcg caagcgcctc taaaagcgga gcattccgtt 1918561 tcatgagaaa ggcaagcagc acaaacagaa agaaaaacgt tgctgtcgga ctgtccggaa 1918621 caaaaatcag gaaacgggcc ggtgtctcca aaagctgcgg caagtaccaa tagtagccgt 1918681 aaaccgttcc cagaaaatta atggctaaga caagaataag catcggccgc tgccctaata 1918741 catattgaaa ccatttcaca tcgaatcaac tctcagtctg taaaaataat atgtccatat 1918801 aaaaaagctg acgccgggtc agcttttgat aataaaagta tatccttcca tttgacaatt 1918861 cacaatacgt tattttgcgg ttgtttcaga aataaatttt gcaagttctt cgagctgctt 1918921 atcatttcct ttgaacacac ccgccggcat tttgcctttc ccttctacag cgattttttt 1918981 gatttcatcc ggtttcagcc cgctgtcaac caatgaaggc ccggccgctc ctccctgaag 1919041 gttatcccca tggcaagaaa tacagccctg ttccttaaaa accttatatc cttctgcatt 1919101 ggtgtcaatg tcggcttctt ttgtaatttt cccctgttct tctgccttgg cccagtcatg 1919161 agtagcaact gactgccacg tcaaaaatac agcagcggaa atggccagaa gcatcatacc 1919221 gacagcgacc ggacgcttcc acggccttct ttctgtccct ctgtctagga atggagccaa 1919281 aagcagggcc ccaaaagcga gacctggcat aatcatggcg ccgaccactg taaagcttcc 1919341 ggcggcgtat tcatacttca acagctggta taagaaaaga aaataccaat ccggcagcgg 1919401 aatataacca gtatcagtcg ggtccgccat ccgctctaaa ggcggctgat gcacaatcgt 1919461 caaaacgaga aaaccgatga gaaagacagc tccaaccatc cattccttta acaagaaatt 1919521 tggccagaaa gcctctgttt tacccggata ctccgaataa tccttcggta tattcggctt 1919581 tttttcagcc ggtatccttg agtcgcctac aaatttcatc cctttgcccc ggtgcatgtc 1919641 atcccctccc ttttattcgc agatcaagag tttaaagcgg tcctgaaatc ccctgcttcc 1919701 ggatcataat aaaatgtgca gccatcagcc cgaacaatgc ggcaggaaga aaaaatacat 1919761 ggatcgcaaa aaacctagtc agcgtttggg cgcctacaat atccggatgc cctgcaagga 1919821 gcgttttaac ttgcgttccg atcaaaggcg tggcttcggc gatctgcagt ccgacttttg 1919881 ttgcaaacag agccttcata tcccaaggaa gcaagtagcc tgtaaagcca agaccgagca 1919941 taacaaaaaa gatcagcaca ccgacaatcc agttcagctc gcgcggtttt ttatacgcgc 1920001 cttggaaaaa gaccctcagc gtatgtaaaa acatcatcac aatgaccagg ctcgcacccc 1920061 agtggtgcat ccccctgaca atctggccga atgccacttc attttgcaaa taatataccg 1920121 attcccaggc atttttgata tcaggcacat aatacatcgt taaaaacatt ccagataata 1920181 cttggataac ggttacaaaa aacgtcagtc ccccaaagca atacacaaac gcagagaaat 1920241 gatgggcggg attcacatgt tccggtactt cgtgatcggc aatatccctc cacatcggtg 1920301 taatatcaag ccgctcgtct acccagtcat aaattttgtt cagcatgtca cccttccccc 1920361 ttaggctttg cttttccaag atacaggaag ccgtctttta cttcttgctc ataatgatca 1920421 agaggcgcaa gcggcggcgt gccagggaca ttggtgccgt ccttttcata gagtccgtaa 1920481 tggcatggac aaaagaattt attcgggttt ttaggatcac tattccagtt caccgtacac 1920541 cctaaatgct tacaaattgg cgaaagtgct acaatttcat ccccgttttt gaagacccag 1920601 gctgatcttg actcttctga ctcataccag gcatcgactt gattaatttt aaaatcaaag 1920661 cgctgcggct cttttgtcaa ctcatcaacg ctgacaacct gaaccatatc ctgcttccct 1920721 gtcgatttta ataccgggtc gagtgcgaag cgaaccatag gcatgagcat actagccgcc 1920781 ataaaacctc ctacgcctgt gagcgtataa ttcaaaaatt gacgtctgga tatatcatgt 1920841 tttccgccca tctcttctcc cccctctaag tcacccctgc aaactgacta aaatagaaaa 1920901 tattgcaata actctagaca ccctcataat atatgaatct ctcagcaagg tcaatatagc 1920961 caaaatattg tttataagga aatgtaagtg tttttataaa gtgctccata actgtaacaa 1921021 aacgttcaaa atttcagcag tgcgttcatc caatattttt ctttttaaag agtcatttaa 1921081 atgctctaat ggaacagacg atgtaacaat cattttgcct aacgcatcct cagctctcca 1921141 actttcgtca gatgtgagca ggacaacatg cggaaattcc gttatcagct cttcccgcaa 1921201 atccttaagc ccttgaacgg ttatttcatt tctatcaaca tatgtataag gcggaagtaa 1921261 atatacccgt ccctttaact gcctttcaag ttcttctgag agaagctgcg taaactcgcc 1921321 tttctccgcc gccattttaa aatggttatt aacccttatg ttaattaatg gtatgacagc 1921381 ggtatcaatg taatccttag cttgtaaata gtccttggca tcagtgattc tccacctcat 1921441 cgttctcccc ctttacggca acaagccttg caattcactg caaggctggt catattatgt 1921501 gagctgattt aattggcgcg ataattgttc aaatgcctct ttatcatgac gatctaacgc 1921561 gtcgtcaatg tcttttaata atttttctct ttggaatgtg gaaatagcgt gctctaaaat 1921621 ctgttccgcc aatccctgat cttttttatt ctcaaaaagg tttttcggaa tatgcgggtt 1921681 ggactccagc accgccgcat attcaggtga gctgtaagcc gaacggaaat taagctggat 1921741 aaacaaatcc tgctgtttat ttaatctaat atcatgaaaa gatttttccg cgtcggtagt 1921801 catgacattc tctttataga accggaacgg aacttcttca acacaatgtg ttgacattat 1921861 aatgcctctc gggcaaaatt cagcctgctc cacaaaatga accttctcca tgagagaatc 1921921 atggctcatt aagtagttca agatccaaac gcactctcgg cgctttaact gataatggtt 1921981 taaaaaccaa cggataaaat cttttttctc attgacagaa acaggggtct gcatgtaatt 1922041 ccctcctcta tcgttcgtat aatctatata cttatatgtt ccacatgaat ggttaatatt 1922101 cctgcttatc tagaaaattc atcctcgatt cgcaaaatcg tttcttcaag ctcttcattg 1922161 gctccgtcca tttcaagaac ctttttcaaa agcggcagcg cttctttttg aagaccttct 1922221 tctaatagga agcttgcgta ttcatataag aaatctctat cctcccggta atgaagatag 1922281 gcagcctcaa aggattgttt tgcttcctcg tattgctcta attcagtata tgcgcttgca 1922341 agataccaat tgtatttagg atcttcttca ccgtagcttc gaacctcttg aataagatca 1922401 atgatctgat cataatcctc ttctttgtga tacacggcaa gaagtgtatg aagcgcctcg 1922461 acaaagcccg gatcaagcgc aagcgcctcc tgaagcagct tcttcccctc ttctgacttc 1922521 ccgattttca aggccatttt ggcggcataa aggaaaagtt ctttgttata ttcatcatat 1922581 ctgatcccct cttttgccgt ttttaatgcc tcttcataca ttccttcagc ttcatagctt 1922641 ttcgagagcg gcatataaag tgaagtataa gatggatcaa gctcctttaa atcagacagc 1922701 tgcttaatag ctgttttcac aagccccgcc tgtaaggctg taaaaccata gccgaaaatc 1922761 gtattaggat caggattctc atcgacagct ttctcatacc atggaatggc atcctcaaat 1922821 tcacctgagg cacttaacga ttctgccagt ctttgatgga cattaacgcc cccgatctca 1922881 ctctgctcct cagccgttgt tttaaaatat tgaaccgctt ttgcataggc tccctgagca 1922941 aagtaaagtt ctcccagtgc aaaatcaata acaggttcat tgtccagaat ggactttgcc 1923001 tggaaaagct tttgttcact gacttcgaat aacccctgca tctgataaag atccgccata 1923061 agcagcaaac tttccggata tgatggatct gtttccggaa tagtctccag cacagcgagg 1923121 gctttttctt cttcgtcaat atctattaaa agttcagcgt agaaattcgt cagttctgtt 1923181 tcatttggat ataaatcatg tagatcacta atcagtgaaa tggctttttc tacatcgccc 1923241 cactcgtaat aaagctgggc tgcaatggct ttatcttcat catgcagctg tttttcagcc 1923301 ttcgagagcg tgttgaggcc tttttctgtt tcacctgctt caactaattt tatggcttct 1923361 tgaatcaatg tattcaaatc ggaccggtcc tttcttttcc tatacaacat caaccataca 1923421 aaaaaagctt tatttgttcg ggttaatctt atcataattc agacgaatgc ccccggcaaa 1923481 taagatgctt ctgtacggaa gggaattatt gagtcttatt agtttaccaa aagatcttga 1923541 gatagaaaat gaaaaaagga agatcgccct ctgtacagta aagcagctct ttgacctgcc 1923601 ggcttgtaag taaagcacat cccccctttt cgtttttcta tccgttctat aagacaagct 1923661 atgttttttc gcctcgaatt atgatctgca taaaaaatcc tgaagtaaaa cttcaggatt 1923721 ttttcgaaag cttatttaaa tgctcgaaga aggttggata agaaacgtga atggcatccg 1923781 tgtgctcgat ttcaatcggc tcctccgtta tacaggaagc aataccaagc atcattccga 1923841 ttcgatgatc tccgtggctg gacactgcag cgccgccttt caacgtttgt ttgccataaa 1923901 ccttcattcc atctgctgtc ggttcaattt cagcacccag cttgcgaagc tcagaaacaa 1923961 cagtatcaat acggtttgtt tctttcactt ttagctctgc cgcgtcctta ataacggtgg 1924021 ttccttccgc ctgagtcgca agaagcgcga tgatagggat ctcatcaatt aaacgcggaa 1924081 tgatatctcc tccgatttca actgccttta gagatgacgt ttctataatc aaatctccat 1924141 aaggctctgc accgctatca gcagatggtt tgatttcaag ttttgccccc atgttttgaa 1924201 ggacatcaat aatacctgtc cgagtcggat ttaaacctac gtttttcaat acaattctgc 1924261 tgtttggaac catcgcgcca gcagcaagga aaaacgcggc tgaagaaatg tctccaggaa 1924321 caaaaatatc agcagctgtc agtttctggc caccagcaat ggaaacactc gtttgatctt 1924381 cagaaagctt aacgccaaaa gcagaaagca tccgctcagt gtggtcccga gatttatggg 1924441 gctctgttac agttgttgtg ccctcagcct gtaatccggc cagcaaaaca gcagatttaa 1924501 tttgcgcgct tgcaacaggt gatacataat caattccttt taatgaagcg ccgctcactg 1924561 acagcggtgt aaactctccg ccggctctgc cgtcgatttt agcccccatt tttttcaaag 1924621 gctcagtcac acgcttcatt gggcgtttcg caatgctctc atctccggct accgcgctgt 1924681 aaaaaggacg gcccgccaat attccgagca tcaggcgaat cgttgtacct gaatttccga 1924741 catctaaaag gctttctggc tctttcaggg catcgattcc ttttccgtga atcacgacat 1924801 cgctgctgct ttgctcaatg tgaacaccca tttttctaaa gcaatcgatc gtgctcagac 1924861 aatctgctcc cggcagaaag tttttaactg ttgttgtgcc tgccgctagc gcgccaaaca 1924921 taacagagcg gtgagaaatg gatttatcac cgggaatatg tatttctcca tgtaaggtct 1924981 gcaccttatc tcgtttcatt ttttccacct caatcagcat aaaaagtttc atattccgcc 1925041 cgggcttcaa tgcattgttc tgcccttttg cggtcgtcat cagactgaaa actgatcctt 1925101 aaaatcccgt taatatcctc tcgtgtttcg ataatgcgga tattcgtgat actgatgcgc 1925161 tccgcagcta agatcgctgt tatctcggat attacacccg gatgatcggg tacatccaca 1925221 tataaatcat aaaatgcagg tatcgctccc ttctgccgaa gcggcagccc gtcgcgataa 1925281 tccttggctg ttttaaaata acgaaataga ttttccgcat cttcttgttc tacatatgta 1925341 cggatcttgt caatttcacg aatccactca tcaaaacggt ctaagatttt atctttatta 1925401 tgtaataaaa tatcccgcca cattgccggg ctgcttgatg caatccttgt aatatctctg 1925461 aacccgccgg cagcaaaacg cttaacaagc ggatacaggt tttccgaatg atgggtttgg 1925521 tgaacaaggc tagctgctac aatatgcgga aaatgactga ttacgcttgt aacgccatca 1925581 tgctcctctg gcgacatttc cacaaaatgg gcattcgtcc ccttcagcag gttttttaac 1925641 tgttccacag cttgtttgtc cgttttctgg cctggcgtta aaatataaaa tgcattttca 1925701 aacaggaact ccttcgcagc ggccactcct gatttatgtg aacccgccat cggatgccct 1925761 ccgacaaatt gatagcggct aggcagcact tgatcagcgt aatcaaccac tttttgcttt 1925821 gtgcttccta catccgtaat caaaagctca tgttcaattc ctgaatgagc cagctcttca 1925881 agcataacca gtgtttgttc aacaggtgtc gcaatgatta ctgtagctgc ctctttcaca 1925941 ccgctaataa acgaatcagc acgatcgtct atcacgccta attttaatgc cgctaccgcc 1926001 tgttcatcag agatgtcgat tccgataatc cgtttgccgg gatgattttt tttgatggct 1926061 agggcaatcg aaccgcctat caatccgaga ccggcgagca atattgtatc tttcatttga 1926121 ttcatacgtc atcacctggt ttatagacta aagaggtgat atttgatcac ctcttataaa 1926181 atttcagcta aaatggcaag tatttcttca ttttgctctt ttgttccgat cgtaatccgg 1926241 agtgatgtcg ggaaacctaa tgcgtttcct gaccggacga tatagccttt ttccagcaga 1926301 gcctgaaaca gttcatcagc aggacgttta aagtcaatta acacaaaatt tgtctgtgaa 1926361 gggtagcact ttaaaccatg agttttcgca aaatcataat actgctgaag gcctgcatta 1926421 ttttgctcga cacaggaagc aataaacgct tgatcatcaa gtgctgcaat cgccgcagcc 1926481 tggcccagac ggctggtatt aaacggctct ctcgccggct caatctggcg aatcaggttc 1926541 tcgtcagcaa ttccgtatcc gactctgagc gctgccagac cgtatgcctt tgaaaatgtg 1926601 cgcaaaatca tcaaattgga atacttgctt aagagcggca cggtttccgg gtaatcctct 1926661 gctgttacat attcataata tgcttcgtca agaacgacaa ggacacgaga aggaacgcgc 1926721 tccagaaatg cgagtaattc tccttcagat gtataagtgc cagtcggatt attcgggctg 1926781 catatccaaa cgacttgtgt ctgttcgtcg atggcttcta acatggcgtc taaatcatgt 1926841 gagccgtcgg gacgaagtgc aatttcacgt acttcagcac cttcaataac cgcattatgt 1926901 ttatattgcg gaaaagtggg ggcagcagta accgtgtttg ttttatcgtt taaaaatgcc 1926961 cggcagatga tctgtatgat ttcatcagaa ccgttgccga aaataagtga tgtttcgctg 1927021 acattgaggt gcttactgag ccttgtccgc aaagcggcgc tatacccgtc cgggtaaagg 1927081 gctagctgtt gaatctcatg atgaagcgcc tcttttgcag cctctgaaca gccgtaagga 1927141 ttctcgtttg aagcaagctt cacaacttta tccaagccat attctgattt cactgcttca 1927201 atcggctttc caggctgata aggcttcagc tgttttaaat gttctttgat acgcaaatca 1927261 gtcacctcat tttaaactgt acaagccgct aaacgccatt gcataatcct caaactcctg 1927321 cagcgcctga tttctcgttt cagcgctgat gagccggtcc tttaattctt ctatttttct 1927381 gacgagcgca cttcccacta cgacaccgtc actaatttca ttcatcttta tgacctgttc 1927441 acggtttgat ataccgaacc ctacagcaac cggaacagtg ctgagattct tcacagtacg 1927501 aatgaacggg tacacggatg aattgaactc attgcggaca ccggtcacac ccagagaaga 1927561 tacacagtag acgaacccct cggcttgttc aataatggtt ttcaaacggc tttcgcttgt 1927621 cggcgcaact aaagaaatat acgtcacctc atggctttta cattcctctt gaaggctgtt 1927681 gctttcttct aatggcagat ccggaacaag cagaccgtca atatgatttt cccgcagtaa 1927741 agcgaaaaag tattctttgt tcaattgtaa cacaggatta taatacgtaa agaggataat 1927801 cggaatattc actccgtttt ttttcatttc tccgcctaat tcgattgcct ttacgatatt 1927861 cattccttga tcaagcgccc gctttgaagc ccgctggatc accggaccgt ctgcaagcgg 1927921 gtcagagtat gcaacaccaa gctccaatgc tgtggcgcct gctttttgga gtgacttcgc 1927981 cagttcaatc gaaacctcag gaactggatc gcccgccgta ataaacggga taaacaattt 1928041 ttctgatggt tgaagatcca atttaaacat gggctttcac ctcttcttcc aatacattca 1928101 ttaatgtgtt gacatccttg tctccccggc ctgataaaca gacgagaatg agttgaccgc 1928161 gatccattcc tttggcgagt ttgaatgctt tcgctaacgc atgggcagat tcgattgccg 1928221 gcaaaatccc ctctttttct gacaaaagct ttaatgcatc caccgcttct tcatcggtta 1928281 tactgtcata agtgacacgg ccgcttttat gcaaatatgc atgctccgga ccgattccag 1928341 gatagtcgag accggctgaa atagagtagg gctcaataat ttgcccgaac tcatcctgaa 1928401 tgagataagt caatgaaccg tgaataaccc ctacggttcc tttcgaaata gtggcggcat 1928461 gaagaggtgt atcaattcct tttcctgctg cttcagcgcc gatcagttca acatcttcat 1928521 ttaaaaatgc ctgaaacata cccatcgcat tgcttcctcc gcctacacat gccactactt 1928581 tatcaggcat agtgccttca atacgtttca actgatcctt cgcttcctct ccgatcattt 1928641 tttgaaattc acggaccact tgcggataag gatgcgggcc gacaactgat ccaatcatat 1928701 aaaagtgatc ctcacaatgc tgaacccagt accggatcgc ctcatttgtg gcatccttca 1928761 atgttccgtt tccgcttgtt acaggcacta cctccgctcc aagaagcttc atgcggaaaa 1928821 cgttcagaga ctggcgggca acatcctctt cacccataaa cacagtacag gaaaagccga 1928881 atttggctgc aactgttgca gcggcaacac catgctggcc ggcaccggtt tcagcaatga 1928941 ttttcgtttt gcccattttt ttagcaagca gcgcttgacc tagcgcatta ttgattttat 1929001 gagaacctgt atggtttaaa tcttctcgtt tcaaatagat tttcgcgccg cctaagtatt 1929061 cagtgactcg atcagcgtat gttaatgcag tcgggcgtcc ggaatagtcc tttaacagct 1929121 tataatactc ttcacgaaaa gcgggatcat ccttgatttg tttaaatgct gtttgtattt 1929181 catctaacgg ctgcatgagt gtttccggaa caaactttcc gccaaaatca ccgtatctgc 1929241 ctatttcatt cggatatgga tacatatcgg ttcatccttt cttctaaaag cctcatcaga 1929301 ttctgatctt tttgtccgtt tttttcaatt ccgctggcaa ggtcaattcc ttctggctgc 1929361 catttcaata ggcgtgtgat gctatccgga ttcacgccgc cagcgataaa gcagcgttta 1929421 ccaatagccg cctgctgata ttccggcaca cattcccaag aaaatgcaac accagttccg 1929481 cctctagacc cttttacaga tgaatcaatc acaaagccgt caacattatc tttaaagcgg 1929541 gctatttctt gagttgtgtt atcttgatgg tgaagcgcct tccatatttc acagcctgtc 1929601 agcttgcgaa gagcagcagc atccgccggt ttttcatcac cgtgaagctg aatgacgtcg 1929661 agcttcaagc tcttggcaat acgtgacatc gtctctattg attcattaac aaaaacacct 1929721 gcaacctgtt tttcgacacg aacttggttc agccattttt tcacatcttc cggagatact 1929781 tttcgtttgc tttcagcaaa aataaatcct aggtaatcag cctgtgattc cgccgcaagc 1929841 tgcaaatcct ttagtgaccg aataccgcaa tattttaatg ccggtttctt cacaacctca 1929901 ctccctaaac aaagcatgga ttgctttacg ctgagaagtt tgtctcatca atgattcacc 1929961 gataagtaca gctcgtgctc catgttcttt gacaaatgtt aaatgttcta aagaaccgat 1930021 tccgctttcg ctgacaagca gtgattcttt cggagcaaga gatgcgattt gttctgtctg 1930081 catgatagag gtttcaaaag tttttaggtt tcggttgttt atgccgagaa tatcaggcgt 1930141 gaatactttc aatatttgtt ctagcgttgt tgcatcatga acctccacta acacgtccat 1930201 ctccttttca cctgcttcaa gatataattc atgaaggtgt aagggatcaa gcacttcgcc 1930261 gattaacaat atggcatccg ctccgattct tcttgattcc tccacttgaa gagaatcaat 1930321 aataaaatct tttctgagta caggtatcga aacagcgcgc tttacgtctg ataaatagct 1930381 gttttcccct tgaaaaaacg gggtgtctgt taaaacggaa agcgcatctg ctttcgcagt 1930441 ttcatagtct tttgcaatcc gcacaggtac aaaattctct ttaataagcc cttttgacgg 1930501 cgacgctttc ttcacttcag caatcaaccc gataaaccga ttcaggcttg ccagcgcctc 1930561 tttaaatgaa cgtttttcga aaggctgctc taccggcaga accagtgttt tcacttcttc 1930621 tttcttttgt ttgatgattt tttcaagcat agatctcttc ctctttctgc tttagtcgtt 1930681 caagctgcgc ggcagcgcct ccgcttgtaa tcgtctctaa cgccagctcc gttccttcct 1930741 tcagtgaggc ggtaattccc gccgtgtaaa tcgcagcacc cgcattaaaa gccgtaatag 1930801 ataaagcgga actgctgctt ttattttcaa aaatattctg aatgagataa gcgctctctt 1930861 tcggagactg cacctgtaaa tcttcaagtc tgccatttgt gaaaccgaaa tcttcgggtg 1930921 aaacggtata ctcccggcgc tctccgtcct ttaattcaat cacgtcggtc ggtgctgtaa 1930981 ttgaaagctc atctaaaccg tcacggcttg atacaaacat aacgtgcttc ggctgaaacg 1931041 tctccagtgc gcttgccatc agtccagctt tttcaacaga atagacccca atcacctgac 1931101 gcttcgcctg taaaggattg ctgagcggcc caagcagatt aaataccgtt ctgaaaccta 1931161 gctcttttct agtacctgct acatgtttca tagacgaatg gtaaagcggc gcaaaaagaa 1931221 atcccatgtt gtttgtttca atgctgcttt tgaccttttc gggagtggtt tgaatagaaa 1931281 cctctagctc ctctaaaaca tcagcgcttc cgcttttaga agagacagag cgattgccat 1931341 gcttagcgat tttcgcacca gctgccgagg caacaattgc cgaggccgtt gagatattaa 1931401 aagtggaaat accgtctccc cctgttccgc atgtatcaac aatatcagga agtccatcga 1931461 ctgtaagagc gtgtgcccgc attgccttca caaaacccgc aagctcttct ggcgtctccc 1931521 cccgatgagc aagaattgac aatatccccc ccatttcaga aggagtcatt tccgctgcca 1931581 tcatcatatt catcagcgtt tcagcctcac cggcagtaag ggtttttccg tcaacgcaca 1931641 attgtagaaa tctgttcatc agctttatcc tccttgctat gaaacatgtc ttctgcaata 1931701 tgaatcgttt tcagcagcgc accggcttta ttacagcttt cttcgtattc ggcttccgga 1931761 acagaatcag caacaatgcc agcacctgcc tgtatcgatg caacaccgtt ctttacactc 1931821 atcgtgcgaa tcgtaataca agagtcgata ttcccgtcaa acccaatgta ggcaatacac 1931881 cctccgtatg tctctctcgg tgttggctcg agttcttgca aaagctgcat ggcacggatt 1931941 ttgggtgcgc ctgttaaagt ccccgccggg aaagcagaca tcagtgcatc gacaggatga 1932001 accccttttt tcaatcggcc tgtaaccacc gagataatgt gcatgacatg tgaaaaggaa 1932061 acaatttttg tgaactccgg cacagaaaca gaaccatact ctgctactct gccgatatcg 1932121 tttcgggcaa gatcaacgag catgtaatgc tccgcttttt ctttttcatc cttcatgagc 1932181 tcaaccttca gtctctcatc ttcagctttg tctgcaccgc gttttctcgt accggcaatc 1932241 ggatggattt ctaagtgccc gtcttgaacg tgtattaacc gttccggaga gctgccgact 1932301 atttctctgt ctagcagttt catataatac atatacggcg aaggattgac gatcctaagc 1932361 actcggtata actcaaaagc atctgctttt atcggcacct caaatttttg tgataaaaca 1932421 ccctggaaga tatcgcctgc ttttatatag cttttgattt tttctacatc agccataaaa 1932481 gccgattttt cataattaga agatactgtc tcaaagctgg gtgtcttgta tgaatcagca 1932541 gaaagaaaca gctcttttat gtttttttgg tccatcattt tttcaatgag attttgaagc 1932601 tccagatgat tttgatggaa tacatccatt ttttcgtttt ttgtttcctc tccagtgagc 1932661 cttgcatatt ggataaagtg gacgtttttg gtttcatgat catacgcaat taatgtccgg 1932721 caaacaaaca gcatacactt ttccatgtct gtttctttgg tatgcgaagg aacagaaggc 1932781 tcaatcagcg ggatcatatc atagcttaag tacccgacag ctccgccgac aaaaggaatg 1932841 ccaagctcag gtgttttgat tttgtatgtg gtattcatcc agttcagcac ttcttttagt 1932901 tcatttcctg tgtaaagaga tttgctgtcc tgatcagcgg ccgaaaaacg gccctgctct 1932961 tctttaattg tgagaaatgg attcaggccg ataaacgaat atctggacca agtggatgta 1933021 tcgtccttgc tttcaagaag atacgtaatc tccctgtcaa gcttctctat catttgaatg 1933081 ggtgtcagtg tatcgactgt gaaggtctcc acaatcggta tcgtgtggtg ggacaagctg 1933141 tcctctaaaa atgcggaaat gtttgattgg aaattcattg ctctcactcc ttatggcaag 1933201 gagaatgaga agatggcatg agaggataaa atactatata acaaataaac ccaaaagaaa 1933261 gacttctttt gggtagaata aacataatgt ctcagctcaa ctaaactcat tctctgctac 1933321 cctattctct aactcaactc attctaattg ctttatacac actcttgtgt atttctaagc 1933381 tgttcttatc gtattacaat tcagtatttt ttgtcaatga taaatcgggc ctcaatacga 1933441 caactttttc taaatataca tgtctgatct gatcctgagg gacatctgtc tggaccgtca 1933501 tcatgactct tatgcacttt ttcagaccgc ctgttacgtc catttcctgc atacatgtta 1933561 ccggtacata ctgccatcct gaaagctcgc gaacagcttt tgccgggaaa acagcgtgca 1933621 aatcaggtgt agccgacaga agcatttgaa caacatcttc cggttttgta tgattttctt 1933681 ctatgatttt ctctaacagc tgtttagttt tttgtaaaat ttcttcttca gtatcccgtt 1933741 caactgtagt tgctccgcga attccgcgaa tcatcatgat gtctcctcca atcgccattt 1933801 gttcagccag ctctcaagtt catttctgga aaatgtatga tcagcaactt tccctaattc 1933861 gttgagcaca ataaactgaa tcttcccgcc acgggttttc ttatcattca tcatacggtt 1933921 caagagaacc gaagtttccg tctcttttct gatttgactt ggataaccca ggctttttag 1933981 ccagctgacc aaacgttttc tgtccatttc acagcctaca gtcttttcgc ttatatataa 1934041 agcaaactgc attccgaggg ctacggcatc accgtgagtg atctgcccat atccatattc 1934101 cgcctcaacg gcatggccga gcgtatgccc aaagtttaag taagctctta tcccctcttc 1934161 tttttcatcc tgctgaacga cagacgcttt aattgaaatg cctttaaaaa tcatgtcatt 1934221 cagctgatca ttagtgatat cacgcagtga gtggatattc agcagctcct ccagaaacgc 1934281 tctgtcatag ataaaagcgt gtttaatcac ttctgccatt ccggacctaa gctctttttc 1934341 aggcagagaa cgcaggaaat ctgtatcata gagcacggct ttcggctgat aaaacgcacc 1934401 gattagattt tttccaagcg gatggttcac ggctactttt cctccgactg cgctgtcatg 1934461 cgccaagagc gtcgtaggca tttggatgaa atcaatgccg cgcataaaag tggcagccac 1934521 aaaaccggca agatccccta caacaccgcc accgaatgcg atgatgcatg aggagcgatc 1934581 catatgaaaa cgaatcgctt cactctgcaa ttttgtgtac atgtccatgg attttgcctg 1934641 ctctccactc ggtaccgtca cttttttcac aggccatttt tcttgcagca aatggagcat 1934701 ttcatcacca tacaggcggt ccacttcttc atccgtgaca aacataatcc ttgttaaagg 1934761 cctgtttaaa gaggttaata gttcgcaagc cttttttctg ataccttgtc cgataaaaac 1934821 aggatatgac gaggaagcag tttgaacatg cagtgtcttc attaaaattc cctcgacagt 1934881 tttctcatat tctccacatt ttctctaatg cggtcaattt gatctaatcc gaattgttca 1934941 acgactgcgt tcgcaatttc ccaagcgaca gccgcttcag cgactacact tgccgcagga 1935001 acagcacagc tgtctgaacg ttcaatgctg gcagaaaacg gttctttcgt ttcaatatcg 1935061 acacttttca gcggtttata caaagtcgga atcggcttca tgactccgcg gacaacaatc 1935121 ggcatccctg tcgtcatgcc gccttccagt ccgccaagtc tgttagtagc acgggtgtat 1935181 cctttttcct cgtcccaaat gatctcgtca tggacttcgc ttccatttcg ccctgctgcc 1935241 tcaaatccga tgccgaattc cacaccttta aatgcgttaa ttgacagaac agcggcagca 1935301 agcttgctat ccagcttgcg gtcataatgg acatagctgc ccacgcctac cggcattccc 1935361 tcgacaatga cttctactat tccgccgatg gaatctccgt ttgcctttgc ttcatcaatg 1935421 gcagccatca tttttttgcc tgcctcttca tcgtagcatc tgacaggaga ctcttccgtt 1935481 acacgctgca agtcttcaat tgacgtatac tctgtttttt cagctttaac agcgccaatt 1935541 tgcaacacgt ggcccgccac cttaatgcca agctcagaaa gaatcttttt agctacagcc 1935601 cctgccgcca ctctgacagt tgtttccctt gctgaagaac gctcaagcac atttctcata 1935661 tcacgatgat tatatttaat tgcaccgttt aagtcagcgt gcccaggtct cggtctggaa 1935721 atctggcgct tcatttcctt ttcttcatct tctgtaatcg gagcggcgcc catgattttt 1935781 gtccaatgct tccaatcgtt attttcaact acgagagcaa ttggcgaacc gagtgtacgt 1935841 gcatggcgca ccccgctcat aattttggcc tggtcttttt cgatctgcat gcggcggccg 1935901 cggccgtgtc ctttttggcg tctggcaagc tcaaaattga tatcttcctc cgttatgtaa 1935961 agcccggcag gtacaccctc aataatggtt gtcagttggg ggccgtgtga ttctccggct 1936021 gttaaatatc tcatgacttc ttctcccttc atcgcattaa cgcttttaag taagactact 1936081 ataacatatt tttcagcaaa aagtcagtct atcttttttg ataaaagaat gtatcggctg 1936141 ggactaggcc aaatttctcg ggattgaaga tttgctcggt gctgccgaca aaaagaactc 1936201 cattcttctt caagctatgt gccattttta aatacagctc ttccttcgcg ctttctgtaa 1936261 aataaataaa tacattgcgg cacacgatta agtcaaagtc ttgttcataa cgatccgcca 1936321 gcaaattgtg ctttttgaat gtaatattct ttttgatttc cgttttcact tcataacttc 1936381 tatttgcgtt ttgcgtaaaa taacgatctt tcacagatag cggcacttcc tgtaaagacc 1936441 gctcctgata aacgcctttt ttcgcttttt ccaatgcttt ttcatcaata tccgtcgcta 1936501 aaatctgata gcccggaaga cctttttgct ggtccaaaag catggcaagc gtgtatggct 1936561 cctcccccgt tgagcaggcg gcactccaaa tttttaaagg cctagaggtc ttgattaacg 1936621 gcagaattgc agtctcaaga acttcccatc ttttataatt acgataaaat tctgaaacat 1936681 tgatcgtcat tctgtccaat gtttcattta agagagcttg atccttttcc aatgccgcag 1936741 caaagtcctt aaagctttgg aacccctttt tctcataaag tgacgttagc cttctcttca 1936801 tttgtgcttc tttatatagt gttaaatcga ctccggttaa ttgtttccat ttcgttgtaa 1936861 atacgctgta tgtatccatc tctactctcc cagtctcgct gtctttttgt cctagtatag 1936921 cttgttttat caggaaattg tattgtttca ataaaaaaat cagcttttca gctgatttta 1936981 gatcgttggg aaaggcagag gtctgatgca cactgccatt caacccttta ttcactttaa 1937041 tgtaaacctt tacaaaacag aacaaaaacc ggcggcgtta tatgttgccg gctctgttgc 1937101 ttattttcac aatgattaat agatccagcc tgccataagc tgctgatatg atactaattc 1937161 ttcattctta aagaaaatgt taatctcgcg ttctgcactt tcgagagaat cagagccgtg 1937221 gatgatgttt tttccgacaa acatgccata atccccacga atcgtaccag gtaaagcttc 1937281 tttagggttt gttttcccga tcagctgtct cgtcacttca atgacatttt cgccttccca 1937341 caccattgcg aatacaggtc ctgaagtaat aaactcaacg agctctccga agaaaggctt 1937401 accttgatgt tcggcgtagt gtttctcagc catttgttca gtcactctca ttaacttggc 1937461 gccagctaat tgtaagccct tacgttcgaa tctagataaa atgtccccaa tgagctgacg 1937521 ttggacaccg tctggtttca ccatgataaa agtcttttcc atcatattct ccaccccatc 1937581 attatgtatg tataggcttt cacactgcac accgaaatcg taacatcttt ctgataatta 1937641 atcaatccgg ggcggagaaa tttcttaata tctacaaaaa ttaaaatttt cttttaccga 1937701 tatattttgc gatggctgca agagacgagc gtgcgcgccc tcgaggaagc gtgtttaatt 1937761 tctgaaaagc tttctgcaga tacatttcgc ttactgccat agatgcttca attgcatctg 1937821 tttttttgat ttcttcaatg attggttcaa gctgttcctg cgttgtctca ctgttaatca 1937881 atttaagctg gttttttaat gcaggatttt tcagggcata cagcactggc aatgtgacgt 1937941 ttccttgaag caaatctcct cctacgggtt tacccagctc ttcctcagtt gaagtaaaat 1938001 caagaatatc atcaataatc tgataagaca tgccgacgta atacccaaac cagtacaatg 1938061 ccttatgaat cttctcatca gctccagacg caatggcacc aagctggcag ctgaccgcga 1938121 tcaagagagc tgtttttctt ttgatacggc ggagatacgt tctgagattt tgttccatgt 1938181 tgtatttgtc tttgatctgc tcaatttccc ctagacaaac ttcaacgatc gtctgtgaca 1938241 aaatcctatg ggctttcggt tcgttaattc tcgtcatcat ttcaagagat cccgcaagca 1938301 tataatcgcc tgtgtacatc gcaatacgat tgtcccactt tgctttgatt gtcggttttc 1938361 ctcggcgaag ctctgcatca tcaatgacat catcatgaac caaagatgcc atgtgaatca 1938421 tttccagagt gacggcgaca tatttaatct tattaatatc ataatcgcca aacatgccag 1938481 aaagcagcac gaaaacaggc cgaatacgtt tccctccggc ctgcagcagg tgaagacctg 1938541 cctcgcttaa aagcgggtaa tcggaacgta cggtttgttc aagttctctt tcgattacat 1938601 caatatcgtc atttaaaaaa gagtaggcca ttttaaattt catatcattc acccaaacat 1938661 ctgtgttttc atttccatcc gatatgcgtg gcagcgactc cgccagtaaa cgaatgatat 1938721 ttaacatttt tcaggcccgc ctcttcaaac aggcctgcca gttccttcat tccagggaaa 1938781 tctctggctg attcttgaag ccaagaatat tctttatagc tcttcgcaaa cagtttcccg 1938841 aaaaacggca taatatactt aaagtacata aagtaagcct gtctgaatcc gaacatttcc 1938901 ggctgggacg tttccagaca taccacctgc ccgcccggct tcactacacg tctcatctct 1938961 ttcagtacag tcaagtaatc agggacattg cggagtccga agccaatggt gacataatca 1939021 aatgtatcat catcaaaagg aagctccatc gcatttccgt gcagcagttc aatttggctg 1939081 aatccgccgt cttttacttt ctgctcgccg acactcagca tattttcact gaaatccaag 1939141 cccttgatct cgccgctttt gcctgccgct tttgcaagag cgatcgtcca gtcagccgtt 1939201 ccgcagcaga catcaagtgc ttttgcgcct tcctttacat tcatgatgcg catcgttttg 1939261 tcgcgccatt ttttatgctg ctgaaaactg atgacagagt tcatttggtc ataattttta 1939321 tatatttttt caaatactcc gtgtacgcgc tgttcttttg agtcctgcat aatggtttac 1939381 ccttcttcca ctttctgatg ataggtttga tcttggctga ttgtcttcag acggtttatt 1939441 aaaatgttct gaataggtga atttagaggc agaagtgact caatgctgtt tttcgctttt 1939501 ttaaaacaat cttctaatat ctcttctttt gtttttccca gctgtataaa actgccgatc 1939561 acatccagaa atgcatcatt tccgttcata agccgcttaa atacaaaaaa atcactcgac 1939621 agctttttcc agcgcgggag gttgaagtgt tccgccacac gatggaataa agctgattca 1939681 acgatgccga cactttcgaa aaaatcgttt tcgtccttga aagaacggtc atacagacga 1939741 attttatgtt cgttgatttc tttaatggct gtagcaagcg tccgaatcat gtagatatcc 1939801 ttcatttcag atagtaaaga gtagtacagc ccgctgaaat aatcgcccgc gagaacagtc 1939861 aattggcggt ttttgttttc gtctcgtttt atgactctag ctgtcgtcac ttcatcatgg 1939921 gtatcaaggg cgctttgtac aagcatcgct gttacaatat aattttctct gtcgttgttt 1939981 tttatgtcgg cttcttcaaa taaagcatga aaaagaagaa gcttatcctc atcaattttc 1940041 ggcgcagaaa tatgcttcgc taaataagga tgagacagct tttgttttaa tttcgtgttc 1940101 agattggcta aagttccgta gatgtcttgc aaaaatatca cccttgtccc caaattcaca 1940161 tttatttctt aatctatgta tgagttttat cttttcattc gcttacgcag gtatcattat 1940221 agcataaaaa aaagaaattg gctgtatcct cccgctgttt gcgagcattt gcttttaaca 1940281 gcggggacag ccagcttatt ttttttcgct tttcatttct ccgtacgcgg tttgaatcag 1940341 tgcctctcct ctgactttaa tggcagaagt atgctctgta aactgagcga tgatcacttc 1940401 tcccttgtcg agtttttcgg aatggtgaaa ctttgtgtct gttcctcttg tcaggccgat 1940461 cacattcact ccgtcctcaa cggctttaat gacgacaaaa tcacttgaat gcttttggtt 1940521 catttatagc accctctatc tttattagtc ctggcgttta atatgttcca atacttctgc 1940581 acgggcagcg gcatcatctt taaaaacgcc tctgactgct gaagtcacag ttttcgcacc 1940641 cggttttctt acaccgcgca tcgtcatgca catgtgttcc gcttcaacca ctaccattac 1940701 gccatgcgga tcaagcgttt ctacgatgct ttctgcaatt gtagaagtga tgcgttcctg 1940761 aagctgcggg cgctttgcaa cggcttcaac ggcacgtgcc agtttgctga gtcctgtgac 1940821 ctttccgcct cgcgggatat atgcaacatg tgcttttcca taaaagggaa caaggtgatg 1940881 ctcacacata gaatgaaacg ctatatcttt tacaagaaca agctcctcat ggttttcacc 1940941 gaagatagtc tggaaatgtt cttttggatc ttcattcaag ccggagaata cttcggcata 1941001 catctttgcg actcttttcg gagtatcaag aagcccttct ctattcgggt cttctccgat 1941061 cgcttctaaa atttgacgaa cagcttgttc gatttgctct ttattaactt ctttcatgtt 1941121 ctatgtcctc caccaatgaa tacatttaat ttcgattcta gcacatatgc cccgctaaaa 1941181 gcaaagtgaa tgccctgtca ggaagcccat gctcttgaaa tatgaaaagc cccttagaaa 1941241 ggggcttttc tgtgaagaaa taaagtgtat gtaagctaga tgcatacacg atctatattc 1941301 acaattattt tccggcaact gcgtctttaa gcgctttacc tggtttgaaa gcaggtactt 1941361 tgcttgctgg aatttcgatt tcttcacctg tttgaggatt gcgtccttta cgtgcagaac 1941421 gttcacgcac ctcgaagtta ccaaaaccga tcagttggat tttatcaccg tttttaagtg 1941481 catctaagat cgtatcaaaa acagagtcaa ctgcttttgt agcgtctttt ttagacaatt 1941541 cgcttgcttc tgcaaccgca ttgataagtt ctgttttgtt catgcctttc acctcctccc 1941601 aaaaggatac attcagttcg tttattatca tttcttcaca gttcagtctg attctaaacc 1941661 tgtctcagaa aaaaatgaga gcaagtaaga gaaagacaat taaacggctt tttaagaaaa 1941721 actgcactct gaggaatgtt tgtccaacaa agtgaagaat ttctgtatgt agagtaacac 1941781 atataaaaag ccatatcaag cattttaaag cgtcaatccc ttgctcgtca aggatttaag 1941841 gtgatttacc gaacgaatat tccttttttt ccttttttca tcctattcct tgatcctttt 1941901 ccattattaa gagcaaagaa aaaagacctc ccattctata aagaggtcta ccggtattac 1941961 aggatgatgg cgattaagcc gccagagcct tcgtttatga ttctttctaa tgtttctttt 1942021 aatttatacc gtgcgttttc aggcatcaat gacagctttg cctgaatccc ttctctcaca 1942081 attgagctca gcgaccttcc gaagatatcg gaattccaga tggagagcgg atcatcctca 1942141 aagtcctgca ttaaatagcg tacaagctct tcactttgtt tttccgttcc gataatcggg 1942201 gcgaattcgc tttcgacatc tactttgatc atatggatcg acggagcgac agctttcagc 1942261 ctcacaccga atcgcgagcc ctgccttata atttccggct catcgagact catatcagct 1942321 aaagcaggcg ctgcaatgcc gtatcccgtc tgtttgacca tttttaaggc atcagacact 1942381 tgatcatatt ctgttttcgc atgggcgaag tcttgcatga gctcaagcag atggtctctt 1942441 cctctgattt cgacgcccac aacttctttt aggatttgat catatagatg atcaggcgcg 1942501 tacaaatcaa tttctgccac cccttggccc agctcaattc cggctaatcc ggcactttca 1942561 atgaattcaa actcgctgaa ttggccgaca accctgtcta cgtcccggag ccgtttaata 1942621 tccttaaccg tttccttcac ggactcctga tagctttcac gcaaccaatg gttttctttc 1942681 agcaccatta cccagcttgg gagattgaca ttcacttcta gcaccggaaa ctcgtagagg 1942741 gcctctctga gcacactcag cacatctgat tcccgcatgc tctctacact cattgccaat 1942801 accgggatat catatttttc gcttaaatcc tggcgcatgg cttccgtttc cgggtgatac 1942861 ggcctgactg agttgatgac cataataaaa ggtttgccaa cctctttcag ctcttcaatg 1942921 actctttctt cagcctctat atagtcactt ctggcgatat ctccaatggt gccgtctgtc 1942981 gtaatgacaa ctccgatggt cgagtgttct tgaatgactt ttcgtgtgcc gatttcagca 1943041 gcctcatgaa atgggatcgg ttcttcgtac caaggcgtat tgatcatccg cggcccgttt 1943101 tcatcttcat atcctttagc gccgggcact gtgtaaccta cacaatctac taatcttata 1943161 ttcacatcga gtccgtctga cacatgaaca gacatcgcct gattcggaac aaatttaggc 1943221 tctgtagtca taatggtttt gccggctgcg ctctgcggca gttcatcctg cgctcgggcc 1943281 cggtctgctt cgttactgat attcgggagc accacaagct ccataaattt tttaatgaac 1943341 gtggattttc ctgtacggac agcacctacg actcctaagt atatatcgcc tcctgttcgt 1943401 tcagcgatat ccttgaaaat atcgaccttt tccaagtgat cccctcccgg acttcctatc 1943461 cttttcaatt ttattaagct ctttcaatca aacacaggac actatatgtg tatgacgttg 1943521 tcctatttga atatgacatc tttagaaaat ttctcatcct caatctatta atataaaaaa 1943581 acctttctcc ctatttgtat gcaagggaga aaggttcatt cctttttcat atcattttct 1943641 aaaaaaacag gttcctgttt gtcatttacc gtatatttta cagaaaacgc ggggacaaag 1943701 ggggtttcat gccaaatcat atcctggatt tcagtcccgg gtttaaacgt ttttttgctt 1943761 tttttgaggc aagaagccag ctcagtccgg taatcggcat atatttctcc gtctccgtca 1943821 atcataagcg gcaaggaatt ccctgagatt gggcttgtca ctgtaagaga gctgccatcc 1943881 ccaagcttct tctcatcgag tgtaaataaa tcacgagata gcacatcctt gtaaggcgga 1943941 tattgatgct cctgacgata catttggatg cgcaatttca catcgcgaat tttttctgcc 1944001 atctttagat caattaattt aacagtcgga tcgttctcta cgtcaacaag cacgtattga 1944061 tagtctcccc cgctttcaaa tgccgtactt ggaggttcag ctatgtatct tggcgctaac 1944121 cggttaaagt ctatcggata tttttgatat agcggtgtcg acatatcttt ggtttgaata 1944181 ggaagcagcc ctccatttgc cttttgaaat tcatcaacag cagattgaac ctgctttagc 1944241 tggtcttgat aaggaatggc atgcacactg cttttccgtt catttggata taaacatccg 1944301 gataaaaaca cgactgccgc aaaaatgatt gcgcacttca gtttacccat acagcacttc 1944361 cttttacagc tttattcatt gacagggccg ctaaaaacca cgacaaacac aataattcca 1944421 gatatgagca tacacatgta tgcgaatgat gaaatcgcaa tcttcaaaaa acggttttgg 1944481 cacttaaagc ggcttaaata gatggaagct acagccagaa acatcagacc catggaccct 1944541 agagcaaacc acattttcat caatgccaga ttcaatgacg tgcgcctccc cgatatgtaa 1944601 gatataagcg ttatattata ttttaatata cagcgccgga aaagatcaac cagattttcc 1944661 atccattgat agaacaaaaa aactgaagca aagaggggga ccttcgcttc agtcaacttg 1944721 actatattca cctgcacgtt taagaaacac tctcttggac ttcgatgcta tagtatgcga 1944781 cttggcatac agatgcatcc tctattgcct aaatcggcaa aatgtttcag gagatcccaa 1944841 gacttgggtg ttcttctgtt tttcgggctt tcgttcaatt aagatatgcg attcaccatt 1944901 tgattgacac ttttacttca cttgattttc aaacgtattt accaaatcct ccatctcgtg 1944961 ggttttccct ctcgccatta aagattcaac agcggtttcc actttttgtc cgttgaatag 1945021 gacctgatgg agagcttctg taatcggcat tttaacatca tatttcttcg aaagctgata 1945081 agccgctttc gtcgtgcgga cgccttcgac taccattccc atctcttcaa gaacatcttc 1945141 aagcttgtac ccttttccga gcaaattgcc cgcacgccag tttctggaat gaacacttgt 1945201 gcacgtcaca atcagatcgc ctactcctgt caatccagag aacgtcaagg gatttccgcc 1945261 cattttcgtt ccgagtctcg cgatttcggc aagtccgcgt gtaatcaaag cagctttggc 1945321 attgtcaccg taccctaaac catctgtaat tcctgcagca agggcaataa tattttttaa 1945381 agcccctccg atttcaactc cgataatgtc aggatttgtg tacacccgaa aattgtgatt 1945441 aataaataga tcctgcacct cttctgctgc cctcatgctc tttgaagatg cagtaacagt 1945501 tgtggggtgc cgcagcccta cttcttccgc atgactcggg ccggaaagga caacgatatc 1945561 ttttctgaca tcactcggga gctcaatttc cataatttca gaaatgcgca gaagtgaatc 1945621 tggctcaata cccttgctga catgaacaaa gactgccttt ttcgttataa aagggacagc 1945681 ctgtctcagc acttcccgaa ttgcttttgt cgggaccgca acgataatga catctgcgtc 1945741 tgaaacagcc tctttcatat ctgttgttcc tttaatggat gtagacagct taacattcgg 1945801 caaataatct ttgttttcat gcaactcatt aatttgatga attaaatctg cacggtgagc 1945861 ccacacacac acttcatttc cattatcagt tagaactaaa gccagtgctg ttccccaact 1945921 ccccgctcca agcattgtga cttttttcat gtttgattca caccttttta ttttctagct 1945981 cttgcaaata ttttgattgg tgtcccctca aaaccgaacg cgtctctgat tcggttttct 1946041 aaaaaccgtt cgtatgaaaa atgcatcagt tccggatcgt ttacaaacac aacgaagctt 1946101 ggcggcttta ccgacacttg agtcgcatag taaattttca aacgagaacc gttatgagtc 1946161 ggtgtcggat tcattgccac agcgtccatg atgacatcat ttaagacgtt tgtttgaact 1946221 cgaagtgaat gattttcact agctttgata atcgcaggca tcagagtatg gatccgtttt 1946281 ttcgttaagg cagacataaa taggattggc gcataatcca gaaattgaaa atgatcgcga 1946341 atattttctt caaattcttt catcgtgctc tcatctttgt caacagcatc ccatttgttt 1946401 acgacgatga cgacggcctt gcccgcttcg tgtgcataac cggcgatacg cttgtcctgt 1946461 tcaataatgc cttcttcgcc atccagcaca accgccacga cttctgagcg gtcaatcgct 1946521 tttagcgccc gcagtacact atacttctca gtcgtttcat agactttccc tttttttcgc 1946581 atacctgcag tatcgacaat gacaaactcc tgctggttgt aagtaaatga cgtatcaaca 1946641 gcatctcttg tcgttccagc cacgttgctg acaataacgc gttcttcgcc gagcatcgca 1946701 ttcacaagtg aagactttcc gacatttgga cgtccgatca gacagaattg aataacttct 1946761 tcattgtatt tcgtttcagg aatgttttta aaatgctctg caacggcatc cagtaaatca 1946821 cccagtccga gtccgtgtgt tcccgaaatt ggatacggct cgccaaagcc tagcgaataa 1946881 aaatcataaa tattcgctct catttctgtg ttatccagtt tattaaccgc taaaacaaca 1946941 ggcttttttg tgcggtacaa aattttcgcc acttcttcat cagcagctgt cacgccttca 1947001 cggccgttca ccataaaaat aatcacgtcc gcttcatcca tggcgatttc agcttgctgg 1947061 cgaatctgcg ctaaaaacgg ctcatcaccg atatcaatac cgcccgtatc aatcaaatta 1947121 aaatcataat tcagccattc agccgagctg tatatccgat cccttgtcac gccaggggta 1947181 tcttctacta ttgaaattct ttctcccgca atccggttaa agattgtgga ttttcctaca 1947241 tttggtctcc cgacaatggc tacgacaggt ttacccatag tacccttcct ttcaatccag 1947301 ccgctttcat ttttacataa attttcaacc ggttattaaa atcatttcat tcacttttat 1947361 gaaaagaaac ccttcagagg aagggcttaa ctcatttatt atatcagttt ttactgggat 1947421 cacaactatt cttaaaaatg tttcacgatc aaatacacgt catctccgat tctgtgagct 1947481 attccatcaa ggatcgcctc aagattttta gcgaaaagct ccatctcctt ttggtcattg 1947541 caaaaaaaga caggtgctcc ccctgcaacc cgatttcgat ttgtcgtgat tacagacaaa 1947601 atcactttcg taagagattc actcatccta tcaccttatc ctgattcttg ataaattcag 1947661 tcggcattct aatcgcattt tccagggttg gaacattgct aataatttga acagccgttt 1947721 cgggatggtg aatttgcggg agaacaaata ctgccactct cccatcattt aaatcccgtt 1947781 ttgcaattgg tgtcaaagat ggctctcctg aatcccgata aaccccgagc acattggaaa 1947841 catcaaataa aatggcctga cgctgcccta aatttgctat cgtcgctgct gaattaaagt 1947901 ttttcggcgt caaaataaag cccatgccat gctttaaaat cagttcctgt ttctctggaa 1947961 gcccgatatt catcatataa atattatcaa caaacagtcc cggaccgtca aagcgcggct 1948021 ttatgtactc gatatctaca atatccttca acacactgcc cgacataaac ttcatggcca 1948081 gtaaaaaaca aacgacagcc gctatgactg cagcccagat ggataaaaac acatacgcag 1948141 aggttgtcaa aagcgctgta aagatcacaa tataatttct gctttcaaac gcaatggcaa 1948201 tcccctcaat atatgtgctt ccccttgaga caagttcata cgaatccatt tgcgtcaatg 1948261 tgttccgctc catgtttcgg acatctctaa attgcgtcgc tgccaatgtt aaaaatgtga 1948321 tggccgtaaa ttcctcctgc aaaagcgccg gcataataat tgcacctaaa ccagccgcta 1948381 tcaaccccag tgcgatgtga atcactttcc catgaacata ggtcggatac tggcggtaat 1948441 ccgttttcag catataaagc cttgtcgcaa ttccggcaat gaccccagca ataatcggat 1948501 agatgtaatc actcatgaca ttttggtagc tcctttgttt gatcttttgc ttttctgacc 1948561 aatctggctt gcgaggtgtt cgtatttaga tatgccaaac agcaatatca tccccgcaga 1948621 acacgcattc agccattgaa agccgccgac agccatagcc ccggccaact tctggatcac 1948681 aaatgaatac accagttcgc cttggcacat ccctaggaca aataagacaa gctgcttctc 1948741 aaaattcctt tcaacagaag ctgttaaaag cactattaat ataacagcag cccactcagg 1948801 ttttatgatg aaccaaaccg ggtcatataa tgcaaaaaga taaacaaacg catacgcggc 1948861 aacaagcgtc agatagacca tgatgtaacg aaaacgatac attcccaaat acccggcata 1948921 gacacatccg caaacgaaaa acatcaaata tgcagcattc agggaaaaat ataaagcgat 1948981 gtcatgtatg cttagaataa tattagttaa aataaagaca gagacggcaa ttcgtctttt 1949041 cgtcttttca aaaataaatg ttgtcagaac ccacagaaac cacattgacc aatagtaata 1949101 aaattgttcc attttacttc ctccatattc ccagtatgga gttcaagcac attttttaaa 1949161 caatcgatct cacattaagg agtatgatca tgggaaaaga cagacaagag aaaaaactca 1949221 aagcttcagg cagagtcgaa tcagatcgcg accagtccat tcactatgac ggagcgacaa 1949281 gccttgaaca aaacggaaga ttcaaaaagc gaaaatcata atacaaaaag cccaaaccac 1949341 atatggtttt gggcttttat catttatcgc acactatagc ttgatgtatt gacccctctc 1949401 tctgtgagcc aatgatgggt ttcacctttg atcacaaggg gcgccttttg taaatcggca 1949461 attgttctgg cacccagcac ggtcataatc aactttaatt cctcaaggat cagctgaatc 1949521 tcctcaagca gtccttcctc accgctgtca gtcagcgctt ttaaaaaatg ccctgccatt 1949581 ccggtgcaag aggcccccag cgcaattgcc tttgccacgt caagcgcatc ttgcagaccg 1949641 ccagaggcga tcatggtgct tgcaggaaac tcagagcgga tttccgccaa acttgcagct 1949701 gtcgaaatgc cccacgaatt aaaaaaggag atttgccgct gtcttcggag attttcgatt 1949761 ttcgagaaat ttgttccccc gtaaccgcca atgtcaacag ctgcagcacc agcttcatac 1949821 agctttcctg ctgatgcttt gctcataccg aagccgactt ctttcacaat gaccggtaca 1949881 ctgacccggc tgcaaatttg ttcaatgcgt ttcaatgcgc cgctaaagct tctgtcccct 1949941 tcaggcatca caatttcctg aatcacattg aggtggatct gcagtgcgtt tgctccaatc 1950001 atctcaacgg cttcctttgc ctgagcagcc gttgcctcgc ttcccaggtt ggcaaaaatc 1950061 agcccgtttg ggttttcctt tcgaacaatt tcataggaaa gacgctctga tggatctttt 1950121 aatgctgaca tttgcgatcc cacagcaagg ggaattccag cctgagaagc cgctcgcgca 1950181 agcgatttat taatctcata tgtaagtttt ccgccgccgc cagtcattgc attgataaaa 1950241 atcggcgaac tgcttgaaag ttcgccgatt tttgtggaaa tatctacttg ttctaatgca 1950301 agatcgggca gactgacgtg aacaaacgta atatcatcaa gacctgtttc ccgcttctgg 1950361 ccgatggaca aggcatgatt gatgtgttgt ctttttcgtt ctgctcgagt cacgtttatc 1950421 accaattatt ttagtttatt cagcttatct ccgatcagat ctccaagctg gaagccagtg 1950481 cttgtttctt ccttcgcttg atattgacgg taatcttcct ggtcagcttt aggcgtttct 1950541 tcaagttcac gcatgcttaa tgaaatgcgc tcctcatttt cattcacatc aagaaccttc 1950601 acttttacag tctgtccttc ttcaaggact tcatgcggcg tgccgatgtg tttattggaa 1950661 atttgagaaa tatgaacgag accttcaaca cctggaagga tttcaacaaa ggcaccgaag 1950721 cttacaagac gctgtacagt tccttcaagc acatcgccag gcttcacttt ttcgccgatt 1950781 tggttccaag gtccaggcag tgtatctttg atcgataaag aaatacgttc attatcacgg 1950841 tcaaccgata acactttcac ttttacttct tgtccctctt caacaacgtc agacggcttc 1950901 tctacatgag agtgggaaag ctgtgaaatg tgtacaagtc cgtcgatgcc gccaatatca 1950961 acaaacgcgc caaagtcagt caggcgctgt actttgccat caagtacact tccaacttca 1951021 agagactgaa gaagttcttg ttttttattc gcttgttcac tttcaacaac agcacggtgt 1951081 gaaaggatca cgcggttttt atcacggtca agctctacaa cgagcagtga cagtgttttt 1951141 cctttatagt cagtgaagtc ttcaacgaaa tgtgcttcaa caagtgatgc cggaataaaa 1951201 ccgcgaacgc cgatatcaac gacaaggccg cctttcacga catctttcac ttcagcttca 1951261 aacacttctt ttgtttcaaa ttttttctca aggtcttccc aagcgcggtc tgcatcaaca 1951321 gcacgtttag ataaaatcaa agcatcgtct tccacttttg ttactttcag gtcaagctcg 1951381 tcgtctactt taacaacatc cgatgctttc tctacatgaa gacttgataa ttcactgatt 1951441 ggaataatac cggattgttt gacattgata atttctacat ctacatgttt gtcttctacc 1951501 tttgtcacaa tccctttaac tacatctcca acctctggca cttgaacatc aatttgattc 1951561 atttcctctg tcatttgaat aacctccttg gtccaaacct acacagctta attaaaacgg 1951621 tttgaaagct gaacatataa catgcccgct tttagccgaa tatgtattaa agaatcatcc 1951681 aaaaaagttt tttgaatgat caataaaaag ttttattagt attaacttct aataaaagga 1951741 caggtttgtc aagcaataac attctatctt cgttgaaaaa ttcaaaaaaa gtggcatttg 1951801 ccatcctcag cgggactttt gctccacagc ctcgaggatt ttatcagcta cctcttgaat 1951861 ggaaagcgat gtcgtgtcga tttcaagagc gtcttctgct ttacgcagcg gagatacttc 1951921 gcgctctgaa tcaagcttgt ctcttcttgc aatttcctca attaatgttt cgtagttgac 1951981 atcaaagcct tttttcacat tttcttcata acggcgtttc gctctctctt ccacagatgc 1952041 caaaagaaag atttttactt ctgcatttgg cagcacatgc gtcccgatgt cacgaccatc 1952101 catgacgacg ccgccttttt ccccaagctg ctgctggcgt ttcaccattt cttctctgac 1952161 acttctgtgc ttggccgcaa ttgaaacttg gttgctgatt tcatctgttc tgatcgcctc 1952221 agttacatcg gtgccgttta caaacacttt ttgtccatct tttgttgtaa tcagctcaat 1952281 gtctgtccgc tttagcagct cagccagttt ttcttcatct gtcagatcaa cgttttcctg 1952341 taaagccgcg tacgtaatcg cccgatacat cgctcctgta tcaatatata tgtacgattt 1952401 tttctcagcc acaattttgg caacggtgct tttccccgca gctgccgggc cgtcgattgc 1952461 aatcgataat ttcttttcca taattcctct ccttgctctt ttctcctcta aggattgtat 1952521 cacgaacttt atgaaaaagg gtgaaaaatt gatgaataat taatgtttga aggtttcaat 1952581 cctattgttt tcctccattt tatccacccc ttcatattga atcacttttg atacgtatgg 1952641 ttcaatatgc tgatagtgaa aaagaaattg gacaccaagt aaaatgatgg cctgaatgaa 1952701 caataatttg atcagcagcc gttcaaatgt tttcattgga gcacctccat tacaaatagt 1952761 atggaagtgt ttgccgatgt ttattccatt cgggcctttc ttctcttatt taactggcgc 1952821 ctgatgcagt attgaagcaa agcctgctgg tcacctgctg caatttctga atactctaaa 1952881 gtcatttttc gtttttctga cttggggtca ttaaagattc gtctgacaac tgcttctgtt 1952941 tctatttgac gtgtgtgctc ctcttcagga agacggatga tcaggcgcaa tgattccccc 1953001 gattgaaaag aaaggccatc agctaaaacc acggcgatgc cgcctgcact gatgttatag 1953061 gatagtgtgc ggatctcttc ttcatttccc ggctgaattt gcacatctaa taccgcatca 1953121 gttcttacat attggcggcg ctggattctt ttcatttttt cacggggagg catttcaaga 1953181 cagatcattt gaagtttgtc cttcacttta ccttttatac ggcttataaa gcgataagga 1953241 acttcgtctt ttcccacaaa ctctaccgtt acttccatat cgttatgtaa aatcacagtt 1953301 cgccctgtaa ctacatcaac aggatacgcg atcaaaagtt cattgttttc gatgctgacc 1953361 gccttgcttt ttgccttttt caattcattt tcttctatat attctaaaag tacattttct 1953421 ccaatctcta tcattgactt cactctttcg cattcaatat actcacgttt ttattaaagc 1953481 acgtaatgaa aaaaaggaaa agacatttag tcctttcctc ctgtttttat aggtctttat 1953541 atataggttc tgcatttttt agtttttcaa ccttttcttc cgatccgtct ttggcattga 1953601 tatacattct gaatgtgtca ttttcaattg tcccaagcat ttcgtagcat aacacttctt 1953661 gacctagttc atttgtaatc aaagcgagcc ttgtttctct cacttgtaca tttttattta 1953721 atttagactt tgcctctgct tcagtaattg caggcttagg tatggttctt tttctgtgag 1953781 atgtgaggaa gtctcttgct gaaaagccga caacctcacc gtcatccaag gccactttca 1953841 tacgaattgc ctcggggtac atccggactt tattttcaac aggaacatat gaaaatacac 1953901 cgattttatc atattgggca ctttcatcaa tttccaaatc atctgtttca aatccgtttt 1953961 tctttaaaaa tgcaagcgct cggttcgatc cgtcatttaa actgattttc tgatctttca 1954021 cttctctgtt ttggatcaag tataccggat gcccgccctt cttcgtaata tccatataaa 1954081 tcactgcttt atggtctggg tctttcatgc tgatgctata tacatcgcga tttgtttttt 1954141 ttccgctctt taccacttta attgaataat tgtcatctgg ggcaaagcgc tcagcaattt 1954201 gttttgcttc ctgttcggaa atttgttttc ccttcagatg gctgaagcct ttctcttctt 1954261 ttttcgtact ggtgaaactc gggccaagat cagtgccagt ggagaatgca ccaacatttt 1954321 tttcgactgt tttaaagctg ttgataatcg tattatcact ttgtttttcg tcagaagcca 1954381 gagccatttc tacgtccatc cagcgaaggt ttttgctcat gacaaggtgc tgaacatgac 1954441 gcaattcatt ttgtatatct tcggactgct gatatagctt atttagtgat gtatactcgt 1954501 ttttatcaag cggcttttgg tccaaatctc tgactgacgt tttatagctg aaatcgccga 1954561 tctttgataa tagctcttca gttttattaa acggcattaa tgtaagcggc agctgactga 1954621 cgctgttatg agcttctgat gtaatcctcc acacatcgat caatgcaggc gacagtgatt 1954681 tttggctgtt catggcaagt gttgttccga ttttatcatg aagctgatcc acctgatagg 1954741 taagctcatg aaacgcccgc tgatagttat tttcagcatg aagaagaact gcgtcttttt 1954801 cctggtgttc tttgtatccc cagtagcctg taccgactat tgcaatacca agcacggcga 1954861 ttaaaattcc tctgatcatt tatcacacct ctttttatgc tttctcatat ctgctactca 1954921 cagaaaatgt gtttaccgat tcttttaatc tgcggacgcc cccaaatcca cggacttgta 1954981 gccgtatccg gattaaagta gtaaagtgct tcctctgatg ggtcccagcc attgatggca 1955041 tccagcactg cttctcgtgc cgtttcattc ggctgcatgt aaatttgtcc gtcggctact 1955101 gctgtgaagg caagcggctc aaaaataacc cccgctactg aatttggaaa taacgggctg 1955161 ttcaaacggt ttaaaatgac tgctgcaata gcaacctgcc cctcgtacgg ctcgccccgg 1955221 gcttcgccat aaaccgcttg agcaagcagc ctgatatcgt tgttggaaaa tccaccaggc 1955281 atgttcgctg ctaccgcatc ctgttttctt gcttttgctg gtgtattgtt ttgctgttta 1955341 ttcgcattcg ctttaggctt ctgcgttgtt ttttccgcag gctgtttctg ccgtgcttct 1955401 gcttgttgtc ttgccttttg tgttgctgct tttgatggtt tcgtctgata ctttagcgga 1955461 atttttccgt aatgcgtgaa tgtattccct ttattgagct gttccatgac atattcacga 1955521 tagtattttg atttacatat taaggtttgc tttgttttag ctcctacaag gccgtcaacc 1955581 tcttttaacc cgaattgatc ctgaaaattt cgaactgccc agtacgtccc ccatccataa 1955641 accccgtcaa tttttccgtt ataatatccg ttgtattgaa gacgcgcctg aagctcgacc 1955701 acatcatccc ctgttgcccc tctttgaatg acctgattcg aaaaggcaga gatcgtttca 1955761 gtattaataa acgtcgttat tgtaaaggaa aaaaggatga gacatgccat aatcgatcct 1955821 ttggacttca tcttttcaag cctcctactg caaattttta agtgtaatcg tattttctgt 1955881 aacgaggtta tttttataca ctctttcctt gttatccctc agaacataaa aactgcacac 1955941 aaaaaagccg cacggttgct gtgcggcttc tatacttgca tcatattaac ggaacgggct 1956001 tttttcgctt tacgcaaacc aaaccaccat aaaaatacca taaatggaag catataataa 1956061 atccaattgc taagcgctgt taggataaaa tcatatgatc catgcaaaag ggatgggaca 1956121 actaaagaaa gagtaagcca ctttacacgc gccttatcag cggaaaaacg ggcttttcca 1956181 aggtaaaatc ccattataac gccaatcaag gcatggcatg aaacaggcag cagcgccctg 1956241 acaaacgcat gctccacgcc gtggccaatt aaataaagaa tattttcgag ggttgcaaaa 1956301 ccgagtgata cacttgcacc gtacacaatc ccgtcataat gctcatcaaa gtgggcgtgc 1956361 gggtaaacac tgatcatcag tataaaccat tttaatgatt cctccaaaaa ccccgaagat 1956421 aaaaaagaaa cgaaaaagct tccgcctcct acattctctt tttcaagtac atactggata 1956481 aacatgatgg gaaatacaag aacaaccccg agaaaaaacg accgtagcac catatgtaca 1956541 ggttcattat catactgatc ttttaaataa aaataactta ataacgcgat gccgggggca 1956601 attcctgcag agatgattgc aaacatcagg caacctcttt cctttatatt cctacatcta 1956661 tcctaccatg ttgtttaaaa ttttacatct gtctgcactt aaaaaaacaa aaagagcata 1956721 cgaatgcatc atatgctcct catctttaat ggttttctct tttggcgatt tccgctgcga 1956781 tatgcccccc gtgaaacctg ccgttttcaa taaatatttc atttgcattg tttcccgcag 1956841 caataacacc ggcaataaag acaccttcaa cgttcgtttc catcgtttct tcgttgaaaa 1956901 atggacgccc tgtttcttta tcaatttcaa caccaatttt ttcaagaaat tgatgatcgg 1956961 gatgatagcc tgtcatggca aatacaaaat catttttaat ggtaatgagt tctttctctc 1957021 cggagcgaaa cacaacttca ttctcggtga ttttttcgac acaagctcca aattccatac 1957081 ggattgtacc gtttctgacg agagcttcaa attccggcag aatccacggc ttaatgctcg 1957141 gagaatactc attgccccta tataaaactg tgacacgcgc cccagatttc acgagttcaa 1957201 gggcggcgtc cacgcttgaa tttttcccgc cgatgacaac aacatcttta tcaaaatacg 1957261 ggtggccttc tttaaaataa tgaaatactt tcggcaaatc ctcaccgggt acgcccatat 1957321 agtttggatg atcataatag cctgtggcga tgatacaata tggcgtcgtg taggtctctt 1957381 ttgacgtctc aataacgaat gtgttatttt gcgttttcgt cactttacgc accatttcaa 1957441 acgcattaac acggatgttt ttccgtttaa cgacttcccg gtaatacgat aaagcctgaa 1957501 ttctgacagg cttcctgttc tctgtaataa atgccacatc tccgatttcg agcttttcac 1957561 ttgaactgaa aaaggtttga tgcgtcgggt aattgtaaat actgttaacg acattgcctt 1957621 tttcgatgac gagggcatca atgccaattt gttttaggtg aatggcagca gatagtccac 1957681 aaggtcctcc gcctataata attgcttttt cttgaatcat ttctgtcaac tcctgcgatt 1957741 ggcatttcac ttcatatttt ctatttccga ataaaaaaat ctcctatttt atcataggag 1957801 attttttatt tttatgcaaa tcatcaactt atatccagcc tctaaaacgc gaagcttcag 1957861 ccattttgcg aacgccgacc atatatgcag cgagcctcat gtcaattctt cggttgttag 1957921 ccatttcgta aatattgtta aatgatttga ccatcatttt ttctaatttt tcttctacct 1957981 cttcttcact ccagtagaag ccttggttat tctgaaccca ttcaaaataa gaaactgtta 1958041 cgccaccggc acttgccagc acgtctggta caagcagaat gtcccggtct gaaagaattt 1958101 ttgttccttc aagcgttgtt ggtccgttcg ctgcttcaac gacaatttta gcccggatat 1958161 tatgggcatt ttcttctgta atttgatttt caatcgcagc aggaacgaga atatcacaat 1958221 ccagctccag cagctcttgg ttggtaatgg tatcgttgaa aagctttgtt acggtaccga 1958281 agctgtcgcg tcggtcgagt aaataatcga tatcaaggcc ttccggatca taaagtccgc 1958341 catacgcatc tgagatgccg acaacttttg cccccgcatc atgcataaat tttgccaaat 1958401 agcttcccgc gtttccgaag ccttggacaa cgacacgcgc acctttaata tcgatgcctc 1958461 tcttcttagc cgcttcttta atacagatgg taacaccttt tgctgtcgca gattctctcc 1958521 cgtgagatcc gccaagcaca agcggtttgc ctgtaataaa tccaggcgaa ttaaattcat 1958581 caattcttga atactcatcc atcatccaag ccatgatttg tgagtttgta aatacatccg 1958641 gtgccggcac gtcttttgtc gggccgacaa tttggctgat cgctctgaca taccctctgc 1958701 tcagacgctc cagctctcta aacgacatat cccttggatc acaaacaatt ccgcctttac 1958761 caccgccata tggaagatca attatgccgc attttaaact catccaaatt gaaagcgcct 1958821 tcaccgcctt cacctctttt tctgttacgt tcgggtgaaa acgtatcccg cctttcgttg 1958881 gaccgacaga gtcattgtgc tgcgcacgat atcctgtgaa aatctttact gaaccgtcgt 1958941 ccatacgaac aggtattttt accgttaata atctcatcgg ctcttttaac aattcgtata 1959001 cctcttcggg atatcccaat ttttccagag ccttatgtat tacggtttgg gttgatttta 1959061 atacatcaag tttgtcctct tctgtatgac cggtgtttcg atcggctgcc atttgagtta 1959121 acctcctaga atcttctgtt tctcacatgc tccctttcag agaatagtat acaccttcat 1959181 atgatctgtg catagaataa acgttatgtt tttccatgtt ttttaacgaa aaaaaactgc 1959241 tgaaatcagc agttttccgt tgcattctta tgaaaaatga gtttgtatcg tttctacggc 1959301 attaccgtcc ataatgagct taccatactc ttgcaggcga taaatcgtta aagttgtcgg 1959361 attgccgtat tcagccagaa ccgccacaac cccttcagcc gtatgtgacc ctagatcttc 1959421 aaggcttaaa aagtactgcc cgtcatagtg gtagacagtt ccccctgtga taccgattcg 1959481 ctgtaagctt tctgaaagct gaatgatatc ttcaaaggaa tggaattgat atatgatgtc 1959541 cgcgctttca tcaagcttga cttgcatttc gatgtaatca tcatcatact catcgtcttc 1959601 tgaatcggcg tcttggttct ttgttacaat cacgaccatc ccttgtgctt ggagagaata 1959661 cacttccact gcaatcggtc cattcgcttc aaagccgagc tctgtatttg cttcattcat 1959721 catatcttta aataactggt ggactttaaa tgagtccttc cagaggtctt cttttgtcaa 1959781 tccccggtct gtcaaatcat cgagggttaa aaagattttg atcttattat aattcagacg 1959841 ctcaagccgc ataacgttcc ctcctgcctc tacttgcaca caaatcatat aacacattat 1959901 atgagatgat gagtcatagg ttcttaattg ttatcagttt acactgagtt cactagtaag 1959961 acaagcacaa tgcagttttt attgccatac ggatttttgc tttttagaag ttattctggc 1960021 ccgcaaagag tcacaatgtg agtttcaggc tcagcaccta aacgaagagg cacttttgtc 1960081 gtgccgtagc cgttgctgat cagatatgcc gcgtttttaa caatacctgt tttccccagt 1960141 tcataaggac cgaattttcc aaacctgatc tggcctccat gggtatgtcc gctgagtatc 1960201 acatcaatac cgtcatcttc attgatttgt tcatgaatct ccggattatg gcaaaccaga 1960261 atattcagct ggctttcatc aagttctttg atggcttcct cataatgatc catctccatc 1960321 ctgatatcat caacccccgc aatcgcaatc gtatgcccat tgtatgaaaa cgggactgac 1960381 tcatttctca gagtgatgac gccgtgcgct ttaaatatgg aatacagctt atgctgcctg 1960441 acttcataat cattattccc ccacacaaac acgataggga ccccgaaatg tacgagcctt 1960501 ttgatgtttt cctcgattct cgcactgggc accccgccct cagctaaatc accgccgatt 1960561 ataaccaagt ggggggcatg gcttcgcgct ttttctaaaa ggtcttgatc gatgagacgt 1960621 ttgtgaatgt ctgaaataaa aaagattgtc agaggcggct tgcccttcat ctttgataaa 1960681 ggaaacgtat gtgtcttcaa atgattgcct tttgctgttg catacatttt tgccgtcatt 1960741 gccgctgccg caacagttag tacaccggca attttcactg atagcttcat aaaaaactct 1960801 ccattctttt tagaacttat caataagacg gacaataaaa aaagacgttt ctatcgtttg 1960861 agaaaacgcc ccattttatt tactttcaaa atatagatta atgtcatatt tgtgcttcat 1960921 catatgaaaa acagactctc tcgccttcca tttatcgggc tgcggccaga gatcagtgct 1960981 tttctgaata atttcacatc tcagtttatg gaaatcagtc tcggattttt cttccttttt 1961041 cttgaaataa tatgaagtgc agtaggcaaa agcggttgcc agcatccaaa ataaataaaa 1961101 ggtatggcta agtatttctt gaagtataag ctgaggctcc gggcttttga tcatgatcat 1961161 aacacataat aagcctaggc agataagtga agcccatcgc catctgcggc attgtgctgc 1961221 ataattttcg aatttttgtt ttcgttttac cagcgcttgg agcatctgtt tggtcggcgc 1961281 gtctgtaaac tgatccagct gattccataa ggattccata cgcttcacac cttgtccatt 1961341 ttcattgcta caatatatga acgtaaaata aaaataatac cctattcatc cattaaaggg 1961401 atgtccaaaa cttgtccggt gtaaacatca tttccattca gatgattata tgctcgaatt 1961461 ttttcttctc ctgtccggct tttataatac ttcatggaaa tgcggtatag cgtttctttc 1961521 ttttggacgg tgtgcttgac aacgcgattc ggcacatttt gaactggctc agctggctgt 1961581 tcttgctgtt gtactgttga ttgggaagag gaagcagccg cggcggttgc ttcctcctta 1961641 tttggcgagt cttctttttc cgctacagca gtctgtttct tatcagcagc tgtttgctct 1961701 tttggcttgg aatcttctgg ctcttttttt gactccttct gcagtgcggt ttctttagtg 1961761 tctgcggtat cgtttttatc ctctgatttc gggacaacct catatttgct ttggctgctg 1961821 tcaataaaaa catcttcata atcgtcatga ttatccgggt ggctctttag ataaaataag 1961881 gtgactaaaa cgataaccgg cacaaataca aatattactg cgagtactgt gaataatggc 1961941 gtttttgttt tgccttgctt ttttttctgt tctctttgat tttttacaga ttgtcttgtc 1962001 ggaaggcttt ctccatcatc gacataatcg tccgccaatg cggcgttttg atcttcataa 1962061 agattctggg cttttcttct ctctactctc gacatgttcg tcatgtttat ccctcctcac 1962121 atgttcaaaa cgaatctgac aggcaaacac ggcatcaatg ataaaatgcg ccgtcatcgg 1962181 aacaaataag ttgccggtcc attcatacat cagaccgagc aaaaagctga ttgctgtcac 1962241 cataataaat aacagccatt ttgacaaata ccgaaagtgc agagcggcaa atataaggct 1962301 ggccgtccat aaaccgatat gagtctgcag cactcctctg aataacattt cttccgcgaa 1962361 agcaatcaga agcgttaaaa atataatatg agggattgac ctcttactga atattttttt 1962421 attgattccg ccgtcatcat ataaatgaga cggaaaccat ttcattactg ccatatcggc 1962481 taaaataaca ataacagcta tagaaacacc ataccagatg attcgcatat cgcgaatgtc 1962541 ccagagcttt aatacgtccc gtacatcctc aaaaaagaac agtcctgctg cagcagcggc 1962601 aaagatgatg agtagctgcg tcaaatataa ctgcttcagc atatcatggt cagtcatatg 1962661 ctgaatataa tctttttgct gtttcagttc agctcaccta cagtctgcaa gctgaatatc 1962721 cggtgcaatt ccgaactcca gctgtctaat ggcgccattt tactccgttc ccctttttgt 1962781 tcatacaagg ataaatcaaa accgcaatgt gaacagcacg ggaggtttcc gtcatcaggc 1962841 tcgtatgatt catcaaagta ggttaacagt gcctgcctta aacagccgtc acgctgaagc 1962901 aaaaatgata cacggtgcat tttttccagc ttcagctcca tgcgatatga aatttctttc 1962961 ttcatcagtt caactgatgt ttttccctgc ataaagagat gaatcatcat acgggcctgt 1963021 gtctctccga cgccatactg aagtaatacg tcacgcagcc ttctctcatc ccgctcctcc 1963081 gtcttctcta gcacacggat tacgtcggcg atttcttcag ctgtgacact ctccatctgg 1963141 ataatttgtt cctgcaattc aaaatcccct ggcgcccgca gcaaaatgct gacactcggc 1963201 tttccgtcgc gtcccgctct gccgatttcc tgcataaaag cttctgccgt ctgcgggaga 1963261 tgaaaatgaa tcacatatct gatatcaggt ttatcgacac ccattccaaa cgcattcgta 1963321 caacatatca catcaagctg gttatgaata aactgctgct gaattaaaat cctgtcccct 1963381 gactccaaac cgccatggta aaagtcggct ctgctgctcg ttttgctttt aatttcaccc 1963441 gctaattcct tagcccattt ccgtgttgga caataaacaa ttcccggacc ttgcaggttt 1963501 tcaaccagct gaatgaccct atctattttt tcggcagtat ccgccgcatt ttcaaccctc 1963561 agtgcgatgt ttgggcggtt gactgagttg agatggcgta cagcatgctg cagctccagc 1963621 aggttcatga catcttgcag cgtttccttt gtagccgtgg cggtcaatgc cagaacgggt 1963681 gggtgtccaa gtttttttct cagctgtccg agctttgaat aatcaggcct gaagtcgtgt 1963741 ccccattcag aaatacaatg cgcttcgtca ataacaaata ggctaatcgg aacgcttttc 1963801 aatttttcca atacatatgg agactgtaaa gcttcaggag acaagtacaa aaatttatat 1963861 cgatgaatat gttctaaaac aaattgtctt tcctgcctgt taagcatgct gttcaaagct 1963921 gcagcacgct tttccccccg ggctttgagc tgctgcacct gatcctccat taaagaaagc 1963981 agtggagaaa cgattaatac catgccatca agcatataac caggcagctg gtagcaaagc 1964041 gatttccctc ccccagtcgg gagcattgca atggtatcct tcccgctgag tatgctttca 1964101 ataatgtcct gctgcccttt tttaaaggaa gtaaaaccaa aaaactgata taacgtttgc 1964161 tgtaatttag tcatattgct gcacctgctt tgtcaatgcc agtctgattt gaaagtagct 1964221 gaaccgctgt tccagcccgt cgcgaatttg tttgatttta ttcgtccgca tccgtttggc 1964281 aaactctgcg atttgaagct ggtcttctgc tgatacatag tcattaatca taaacgcagg 1964341 ctcatggaga gaaatctcga caatgtggtc ttcaatcgtc gctgttttca gctttctgat 1964401 ttcagcaatt cgctgtatcg gaaacccttg tttgaccatc tgccatgttt tcctcgtcga 1964461 ctctgtcagg gcattatcta agtgcacatc agaaaggaga tcctttaaca aagcatcttc 1964521 acactccgga agagaatgaa taaaataatg taccgaagcc caaaacatga tatagacata 1964581 ccattcgtct tctttcagcg tatcagcaag ctgcctgctc gtataaccga tccgatggtg 1964641 cgaggttaag gagtagacaa aaatttgcgc tgctttgttt tcaatctttt tcaaatgcgc 1964701 ctcaagcatg gcaaaaaggc tttttgccat ctctatatga tccgtatgcc gggacaggta 1964761 tttctttacc cagtgaagtg tcttatgatc ctttgtgaca gggatatact gcctgctccc 1964821 ttgctgttta tgggatagga cctgcacaag cagcgaaagc cttttccaaa gcacgccggc 1964881 agcctgctga taatgagcgc cgtgacaatg aacgggccaa ggccgctcgc taagggcatg 1964941 tctcaaaact gctgcgccgc tggctgtcac tttgtatgta tctgattcag acattggcgc 1965001 gagatatgaa tgcttttcaa gcttgtcaag cgacgcagaa atatcgcttc tcgaacattt 1965061 tgccgccatt ccaaagtatt ttgcagtctg aaataagccg gcatcttgaa tggtctgtga 1965121 cgatctcttg cctttgaata ggtgaaaaac agcgcttccc gaccgttccc cgtttatttt 1965181 gcaaagacaa tcgagaacca taatatcgaa gtaatttaat gacaacctat ccacctacat 1965241 tcttcctgac aaaaatcgtt gatttgctct ttttatttta acagatttca aacagaaatc 1965301 gacgtttaaa gtcatcatta agggggatgt tatgtagata accccttatg tgataagcat 1965361 tctcaatcat ttttctgttg aaatgtggca gcaacatcat tacaataagt aagaggaata 1965421 ggtgttaaat tgattaaata taaagattga tccatttgtt ccaccaagaa caatctggga 1965481 ggttttattc atggcaaagt acacaatcgt agacaaagat acatgtattg catgcggcgc 1965541 ttgcggagct gctgcaccag acatttacga ttacgatgat gaaggcatcg cgttcgtaac 1965601 gcttgatgaa aacaaaggtg ttgtcgaagt tcctgaggta ctggaagaag atatgattga 1965661 cgcatttgaa ggatgcccta ctgattccat caaagtggcg gatgagccat ttgaaggcga 1965721 cccgcttaaa tttgaataga agtaactaaa aaaagctccc gaacgggagc ttttttattt 1965781 aatggatatg tgcacttcgc tgctgctcaa tccatggctt aagcttgata aaaattagtg 1965841 agaatacaac cgtaattaca atacctttta tcatgttaaa cggcaggata cctgcgacga 1965901 ctgctgtttt tagcgcgctg tcggataatg ccggtgaatg taaaaaccac gtgtatgccg 1965961 gaagaatcag aacataattt aaaatactca ttaaaatggt catcgctgca gttcccaaaa 1966021 gcaggctgac agccaagccc tttgctgagt tgagtttttt aaataagaaa gcagtcggta 1966081 atataaagag tgttcctgca ataaaattcg caacttgccc tacaggaact ccggccatgc 1966141 ttccctgaat gatatactga agaacatttt ttatcgcttc tacggcaata cccgccaaag 1966201 gtccgtaaat cagaatggca ataattgcgg gaacgtcgct aaaatcgatt tttaaataat 1966261 ccggaagacc cggaaacggg aaatttaaca gcatcaaaac aaatgcaatg ctgctcagca 1966321 tgctgaccac aactaatttt tttactttca cttcattctc tccttttcga tcacatctta 1966381 ctcgaaaacg gaaaggttct tttccagcca ataaaaaaac cgcttcatat ataaaagcgg 1966441 ggtttcgaaa attaggctag gcaaagaaac gtttgaaaaa ttcaatttca aaacgcttat 1966501 gaacctccat cttctcccat ccagactgta ctgtcggctc cggaatctca ccgaatcctg 1966561 ctgtaaagac agctcgcggg cttagagcca ttggctcatc accgccggta gggaatttca 1966621 ccctgccccg aagattgatc atatgaaatt taattacatt ataaacgata actggttggc 1966681 tgtatagaga attgcttcaa attaaatata ttacctgcaa gctgtcagat cattgattta 1966741 ttaggcttta cttttatcct ttactgcgtc aatacacgtt gacactcttt tgagaatatg 1966801 ttaaattatc agatatttag tttgtcaatt taggaggaaa tctaacgatg tttcgagtat 1966861 tggtctcaga caaaatgagc aacgacggtt tacagccact tattgaatca gactttattg 1966921 aaatcgttca aaaaaacgta gcagatgcag aagatgaatt acatactttt gatgctcttt 1966981 tggtgcgaag cgcgacaaaa gtaacagaag accttttcaa caaaatgact tctttaaaaa 1967041 ttgtcggaag agccggtgtc ggtgtcgata atatcgatat tgatgaggct acgaaacacg 1967101 gggtaatcgt gatcaatgct ccgaacggca acaccatttc gacagctgag catacatttg 1967161 caatgatctc ttctttaatg agacacattc cgcaggctaa tatctcagtg aaatccagag 1967221 agtggaaccg cacagcttat gtcggttcag agctttatgg aaaaacgctt ggtattgtag 1967281 gattaggccg aatcggaagt gaaattgcac agcgtgcgag agcgttcggt atgactgtgc 1967341 acgtttttga tcctttctta acggaagaaa gagcgaaaaa aatcggcgta aacagccgta 1967401 catttgaaga agtgcttgaa agtgcggata tcattaccgt tcacacgcct ttaacaaaag 1967461 aaacaaaagg cttattgaat aaagaaacga ttgcaaaaac gaaaaaaggc gttcgcttaa 1967521 ttaactgtgc gcgaggcgga attatcgatg aagcagcact tctcgaagct ttggaaaacg 1967581 ggcatgttgc gggagcagcg cttgacgttt tcgaagtcga accgccagtt gacaacaaac 1967641 ttgttgatca tccattagtc attgccactc ctcacttggg agcatcaacg aaagaagcac 1967701 agctcaatgt cgccgcccaa gtgtcagaag aagttctgca gttcgcaaaa ggcctgcctg 1967761 tcatgtcagc tatcaacctg cctgccatga caaaagatga atttgctaaa attaagcctt 1967821 accatcaaat tgcaggaaaa attggcagcc ttgtatcaca gtgcatgaaa gaaccagtac 1967881 aggatgttgc cattcaatat gaaggcacaa ttgctaaact tgaaacatcg ttcattacaa 1967941 aagcccttct gtcaggcttt ttaaaaccgc gcgtagactc tactgttaat gaggtcaatg 1968001 ccgggggtgt cgcaaaagaa cgcggcatta gcttcagtga aaaaatttcc tcttctgaat 1968061 ctggatacga taactgcatc agcgtaaaag tgacaggaga ccgcagcacc tttactgtaa 1968121 cggctacgta tattcctcat ttcggagaac gaattgtcga gatcaatgga tttaatattg 1968181 atttttatcc gactggtcac ttggtgtata tccagcatca agatacaaca ggtgtcatcg 1968241 gccgagtagg acgtattctc ggagataatg atattaacat tgcaactatg caggttggcc 1968301 gtaaggaaaa aggcggagaa gccatcatga tgctttcctt tgacagacat ctggaagata 1968361 aaattgtgaa agaactaaca aatgtccctg atattgtgtc tgtgaagctc attgatctgc 1968421 cataattaaa aaaactcaag ctatatagct tgagtttttt tattgttcta tccccgtgtg 1968481 tttttatgca aaatatctaa gacactcctt agctcagaaa caggaatttg gcctggtgcg 1968541 gacgcctctt ctccagctcc aaaagtacaa gccgatccaa aaacctcacc gctcagcctg 1968601 ctgatgagcc ctgttgcagc cattgacatt gtaataatgg ggcggtctgc atatattgtt 1968661 ttcattgtat acgtcgcatc aagcagtgtt aggagatctc cagtatcatt cggcatgaca 1968721 gccatttttg gaatatgcgc gcctaagtcc tgcatttttc gaagtctgga aataatttca 1968781 tcttttacag gtgttttttc aaagtcgtga tttgacatca ccacatagac gttgttttct 1968841 tccgccagcg atactaacgc ttttacattt gcatctcctg aaaataattc gatgtctatc 1968901 agatcgatgt cttttgtttg gattgccgat tccagcaaag caagatagga gctttcgtcc 1968961 atctccatgc tcccgccctc tttgtgggtt ctgaatgtaa atagaaatag cttgtcttct 1969021 aaagatttac gaagcttaga aatgagcttt gtgaccgctt ctctgtcatt cgctttttca 1969081 aatacgtcga ctctccattc aacaatgtcc ggattcagta attttactgc ctctgcttca 1969141 ttcagaattt gtttttccgt ctttcccatc agcggaatga tgattttcgg catcccttcc 1969201 ccgatggaaa ctcctttaat cgttaacacg ttcactcgtc tcaaatcctt tcaatcttta 1969261 ccttgtttta ttatacacgt acaacttttt tttgaaaatt tctattatat gaatagcaac 1969321 taaaaaagag ccttaaaggg ctctttttag tttaaggaaa tcggatttgg agcagctggc 1969381 accggaattg catctgatat gtcatatttg ccgatttttt tcgttctggt ttccgtaaag 1969441 gtcacttctg tgaagccaaa ctcttttgca gtcaaaagta gtccctcaat cattaaaata 1969501 ccggcaatag aatcatcaac ttctgactcc tttgaaaagc ggatatataa gtgtttctgt 1969561 ttcttcgtta cagattggac agcacccgct tgaataagag gtgtcgtatc ttcttggctg 1969621 ctcgattcca tttccttaat cgcttctttt actgtatcaa aagaatgatt tgacggaacg 1969681 agaaagtctt gtccttgttt attttggtac aagtagtagg atcgttttga ctgtttggga 1969741 atcgaaattt ccgtaaaagt gccatatgag ccaatccgaa ccccagtctc attttgatcc 1969801 gataaaaatt tgactttttc ataaggactc cattttaagg attctttaag caattttttt 1969861 aacagtgtat catcttttat agaaaatgcc gtagctggct gatggactcg tatacttaat 1969921 tccttctgct ttggtttttc ctttatttct acttcatcta tgaaggttgg aattgtaatg 1969981 gcatgatcaa ggatgcccaa ttcactactt tcaaacagca tatcctggat cgtttggtct 1970041 gcatttgttt tttgaatgct gacgggtatg attgcagatg tatcggcatc agcaaccgct 1970101 acagtgatgt aattgtcttg ttccttttca ggaacgacaa acgatgtctg atccaaggac 1970161 gatgcagctt ttgggctgtc ttctgtctca gttttcgtta ctgcgttctc ttgggacgct 1970221 tctttttgtt gaggctgtgc ctgatcaaag aaatgaggag aaataatgaa ggcgatataa 1970281 accgcaattg cagcggcaca cgcggggcca atccacctga cagcgggctt atttttacgc 1970341 tttgccatcg tcagccgctt gtaaatatcc tgaggcgaac gatggtcttt aactgccgga 1970401 agttgactta acaactcctt tatctgttct tcgttccatt ctgacttcat catccattag 1970461 ctcctccctc aaaagctcca tatgtttccg aagtactttg agccctctgt gttgggtcgt 1970521 ttttactttg ctttccgaga agcgcagagc cttggctgtt tcctgtattg aatatccctg 1970581 aataaaccgc aagataatca cagctctttg atcgattgta cattgatcaa gcgcagcata 1970641 aatttcccgg acattttcat gttgaaccgc aagttcgtcc ggcagcaatt gctgatccct 1970701 gacatcctgt gtatcccagt caaatgtacc gagtatacgc tgtctgattg tttgctgttt 1970761 acggaaccag tctatcgcaa catggcgtgc gatagacaaa agccatgttt tttcactgct 1970821 tcttccttca aacgtatgat aagaatttaa tacccggata taaacctctt gaagaaggtc 1970881 ttctgtctgg tttttatcct ttaccatata aaataaaaat tggtacaaat cttgatgata 1970941 tgtatcatat aataattgaa aggtttcttc catttgaaac ccctccgttc acttttttgt 1971001 cgtatgaata gcttgaaaag ttacattaca actatattac gagtaactgg aatttggaag 1971061 ggaatttata ttaacatatc cttaaatttt attaatgttg gctattaaaa aaacacccgc 1971121 tcagtcagcg ggtgtttctt atggaacaag attcttcggc aaattcagac tcgattttac 1971181 cgttttgtcg gaatataaaa agaaaatgtt gttcctttat ctattcggct gtgcacagta 1971241 attgatccgt tgtgggcttc cacgatattt ttaacgatag ccagccctaa cccggttcct 1971301 gctctgcccc ttgtccgcgc tttatctgcc ttataaaacc gctcaaagat aaatggcaga 1971361 tcttcttccg gtatgccaga cccggagtct ttgatatcaa ttttcaatcc atccttcaca 1971421 gaatggactg aaatggagac actgccgccg gctgaagtat gccgcagcgc gttatcaatc 1971481 aaattggtaa atacctgctc catcttgtct tcatcaaaca taaattcctc ttctgtgaga 1971541 gaaatgtcat gatctaaagc aatatttttt tctttcgcaa caccggaaaa cttccgaatg 1971601 atcttttcta aaaactcatt cacattgatt ttttcataat gtaagcctgt atggcctgat 1971661 tccattcggg ctaaatcaag caaatcatta actaaacggc ccattcggag cgattcgtca 1971721 taaatgattt gggcaatttc tttccggtct tcttcagagc ttgcaatgtc atcgacaatt 1971781 gcttcactgt atccctgaag catggagatc ggtgttctca gctcatgact gacatttgcg 1971841 ataaagtcct cccgcagctt atcaaggcgg cgttcttctg tcatgtcacg cagtacggca 1971901 accgctcctc tgacgtgcga ttccgcataa agcggcgaca tcaaaagcac ccatgatctg 1971961 ccttgaagcg tcatctcaat catttgttct ttttcagtgc tgacagcgtt ttgaaacagc 1972021 tcttttgctt caggcggaag attgtcgcct tctttgatat tcatgttctg ttcataatac 1972081 caagcctgaa gaaaacgttc agccggcggg ttggtcacaa gaatcgtacc gtcaatatta 1972141 atggtaataa ccccgtcagc catactgctc aaaatgttag aaagctgctc tttttcttga 1972201 ttgagcgcat tgatatgaaa gttaagctgc cggcccattt gattaaaagc ggtcgccagt 1972261 tcaccgattt catcctgagt taaaatcggg atttttgtat cgaacttgcc cttcgccaaa 1972321 tcctgcgcgc cttctctcat ttttcggaga gggtacgtga ccctgcttga taaaaagaat 1972381 gcgaaaaatg tggtcagcac aatcgcaatt ccagcggcaa gaaaaatata gcgggtcgta 1972441 tgttttgttg tatctttaac ggcaagcaaa gactgggata aaaagaccat gcctttcttt 1972501 ccgtcttttt catacgggac acctacaatc aggcgttcat tatccgtgtc tgtatcgctc 1972561 agtcccgtcc gtttgcttac ttttttatgg tctttgagag ctttatttaa gtctttgtca 1972621 tgctgtattt gctcaaccgt aatagacgac aggcgatttt tatcattcgg agaataccag 1972681 tggttcttct catcctggat gatggcaatg cttgttaagt tatcagcgag ttcccaagtg 1972741 attgaccttg ccagtgcctg gtcctcgtga ttttctagga tgacagcaac tttattcgca 1972801 agctgtgtta aatcattctc agcttcttcc acatggtagt tttcaataaa ctccagcaaa 1972861 agaaccgtta aaatgaacaa tacgatcaag acgagtgaaa ggatcgtaaa ccacagcttg 1972921 cctactacgc ttttccaaaa tttcattcag cgccgacctc aaatttataa cctacacccc 1972981 atacggtgac aatttttttc gcagcttccg gagatacctt gttcagcttc tctctcaagc 1973041 gtttgacgtg agtgtccact gtccgtaaat caccaaaaaa ctcatattgc cacacttctt 1973101 tcagaagctt ttcccgatca tacaccttgt caggcgtttt cgctaagaaa tatagaagct 1973161 catactcttt tggcgtcagg ctcacttctg ttccatcagc tgttacgcgg tgagcatcat 1973221 ggtctattga cagatgtgaa aacacgagca catttttcgt cggtgtattg gcattgaaat 1973281 aagaggtttg ggatgctctt ctcaaaaggg cctttacacg cagcacgact tctctcgggc 1973341 tgaacggctt aacaatataa tcatctgttc ccgcttcaaa cccctgcacc cggtttgctt 1973401 cttctccttt tgcggtcagc ataataatgg gtgtcgcttt tttttcacga atttgccggc 1973461 acacttcaat tccatcagtc cccggcatca tcagatcaag caaaattaag tcataattgg 1973521 cttcaagccc tttggcaatg gcttcatcac cattttcagc ttcatctata gcataatttt 1973581 cacgttcaag atacattctt aaaaggcggc gaattctggc ttcgtcatca actactaata 1973641 tttttgtttc gttcgtttgg tccatgtttt ccccctgctt tccttctgtt actttcattt 1973701 tatcaaatcg tgagaaagtt tgagaactgt gtcgctttca aaggactatg cataagaatg 1973761 aagtccggca agcacaagat ttacgaatat taaattaaac ataataatag caaaaccgat 1973821 tacggccagc catgctgact tctcaccgtg ccagcctctt gacagtctta aatgcaagta 1973881 agcggcatag aacaaaaatg tgatcagcgc ccatacttcc ttagggtccc agccccaaaa 1973941 tctggtccac gcgagctgag cccaaatcat tgcaaagatc agcgcgccga gtgtaaagat 1974001 cggaaatccg attgatacgg ccctgtaccc aacctcatcc accagatcaa gattgacgtt 1974061 tttcaccagc ggatgtaata gagcgctgat tctttttctg atgatcagac ggagagcccc 1974121 atacaacaca agacctgctc caaatgacca aatgacagtg ttcacttttc tgcctgagaa 1974181 aagcgcggga agatcaacaa gcggttccat tcttccttcg gtcaaaagct ctccctgatg 1974241 cggaccgaca agcgcgggca tttcgtacac catcacgctt ttttctttac ttttgtccac 1974301 ccagttaaac tccgcttcat agcctgcaag acgaaatgcc gatgtgattg caataaaggc 1974361 gacggttgtg accaggataa acataatcgc ttcaagccag aaggtctttt tgcttggctt 1974421 tgtctggtct acatgcttca aaagaaagat gacaccagcg acaaagctga tggcaagtat 1974481 agcttgccca agcgcggccg ttgttacgtg aatatacagc cagttacttt ggagcgaagg 1974541 aattaaaggc gagatatctg tcggaaacat gctggcgtag gcaatcagca ataaagcaat 1974601 tgacagcgta aacaggccta atgaaggcaa tctatagaga aaataaagaa tgataaacgc 1974661 caaaacaagc atcatgccaa aagcggtggt gaattcaaac atattgctga caggcgcatg 1974721 gccgcttgca gcccaccttg tgatgaaata tcctaggtgg cagaaaaaac cgacaataga 1974781 aagggtgatt ccaatgttgg cccatcggtt tggcctgccc tttttatctt tattcccgcg 1974841 tatggccccg ccgaagattg ggacagcgat taaatacaca agaaaggccg cataaagaaa 1974901 atttccgctc agctctgcca tgacatcact cccttttcgc ctatttctgt gttttgatta 1974961 attctttttg gtccaccggt tcagtcagtc cggaatcagc caatataaat gctaaatcct 1975021 tcttcaggcc aaaccagttt ttattggtat gccctgctac cataactgca ccgtcctgtg 1975081 agtgcagcca aattcttcga tgctgccagt acataccttg aatgacaccg atcataaaaa 1975141 tggctccgcc gacagcaagc acccagagtg tcagatcctt tctgactgta agtccagtaa 1975201 tgtttttcgt ttcgacatgg tcaaatttca gcttgtattt attattgcct gatccttcga 1975261 tggtttcttg gatggcgaca aagctctttt cgcctttcgg tttgtccggc gttatgatat 1975321 taaagacaaa agccggattg ttagggatct ttgtttttgt gctcggctct ccgtcctgat 1975381 taaaatagaa gtcaggcagg tagctggcga tttccacctt gtaaccgtta ccaagatcat 1975441 agactgaatc tggatccaga aggttgatct tcaggctccc aaaggatttt tttgtttttt 1975501 tatcaatcag ctggaacacc atttggtcaa gctgattctc tttgtaatcc acctggtaaa 1975561 cggaaaaaga atcaaaacgc agcggctgat tgacacggat gtcttcttct gttacttttt 1975621 ccagcttcgg cttctcgcca taaacaattt ttccttctct cttgtagagt acggcatcag 1975681 tttgaaagtt ctttgccact ctaccgtccc cgactctgtc aatggcatct gcaaatacct 1975741 ttttttccgt tttgctgtta taggtctcta cgctgaattg attgtttttc aaataatatt 1975801 ttccgtctgt acccggaatt gctgcggttt cgccttctct gacccaaagc gtctcatcga 1975861 cgtacatgcc aggcacaaat ctcagcatcg caccaatcag aaagatgatc aatccaatgt 1975921 ggttgacata cgggccccag cgggaaaagc gtcctttttc agcaagaatg ctgccctctt 1975981 tttctctgat tctataatgt tttttcttta atagagtaac tatcttttct ttcgattccc 1976041 cgttcagtac agtaactgtt tcactgaaca agcgctgcct tcttaaaaag gccgggctcc 1976101 ttctgacacc ttggtttttt aacgctctat acaacggaat gacccgatca aggctgcaaa 1976161 tcacgagtga aatgccgatc gaggcaatga gcagcaaata ccaccaagaa ccatataaat 1976221 gatgaaaccc gagcaaataa taaagctggc caaacgtgcc gtactgctcc ttgtaataag 1976281 tatcagcctg tgcgcccgga ggcagatagg cttcctgggg aaaaatggtg ccgaacgctg 1976341 atgcggcaag ggttatgacg ataagccata ttcccacctt aaccgaggaa aagaaattcc 1976401 aaattttgtc gatgatcgtt ttgttatagg tttgcgaacg tcttgcgctt ccgtcatatc 1976461 tcatatcagc gagcggaggt tgagtttcct gaagagctct tccgcacgat tcgcataaaa 1976521 cggttccgac cgggtttata tgtccgcatt cacatttgac ttgcttcatc ccgaagtctc 1976581 tccgggtttt atgagattca tataatcgtg tatcatgctt tctgtcatag tgccggtcac 1976641 caccttgaca acttttcctt ccggattgat caaaaaggtt gtcggaagcg gagatacgtc 1976701 ataggcatca agcacttggc gatctgtatc cagaacaacc gggaaattga ctccgtagga 1976761 tttcataaaa ttatgtactg ctatctttga ctccccaaca tttacagcga caatttcaac 1976821 accttggctt ttaaaatgct tatattggtt tgccatataa ggaaactctt ttttgcacgg 1976881 ttcacaccat gtaccccaga aattcaaaaa aacacctttc ccttttaagt cactgagctc 1976941 gatacgtttc ccattcgtat cctctaggac aaaattcggt gcgtcggacc cttcggatat 1977001 actctctttg ccggcaaata cagcgttgta aatggtatag ccgagtgcgc agattaaaac 1977061 gagaaggatg ccggtccgaa tgaataaacg cctttttttc ttcattgtcc actgccccct 1977121 tccccctatt gcagatccat tcaattatat cattgcacgt tcatttcaca tttcttactt 1977181 tttgaaggtt atgtgaaatt tagaaagcgt ttttaccgtg atccgccagt gctctgagcc 1977241 tttttacttc gtgaggcgta agctctctgg catcgcccgt gtgcaggcct cgcaggttta 1977301 aaaacgcgta ttcctcacgc ttcagcttga ttacctcatg tccgatcgct tcaaacatgc 1977361 ggcgcacttg tctgttgcgt ccctcatgga tcgtcagctg aataatgctt gtctgctttt 1977421 tcttatccaa agacagcagc ttcgctttag caggcgctgt tttgccttcc tccagcctaa 1977481 ttccgcgctc cagctttctg agcagctctt taggcgggat tcctttcacc ttcgccacgt 1977541 atgttttgtc tatttcatac ttaggatgca ttagcttatt ggcgaattcg ccgtcattgg 1977601 ttaaaagcaa aagaccgctc gtatcatagt ccagacgccc aatcggataa atgcgctgcg 1977661 gaatattttt aaaaaagtcc gtcaccactt tgcgtccttt atcatcttgc gctgcggaaa 1977721 taacgcctct tggtttatat aagagaaagt aaaccggctc ttcgcgttca acctttaacc 1977781 cgtttacctc aatctgatca gaaccggtga ccttaacacc tagctctgtt actactttgc 1977841 cattcacctt tacttttcct tctttaatca gctcttctgc ctttctgcgc gacgcaactc 1977901 cggcatgagc aatcactttt tgcagtcttt ccatgtcttt cacctcaagt attatcttac 1977961 ttttttcaac cttaacaaac aagctttttc aaattcctat gccaaatcta aaaaaaacgc 1978021 cgttttcagg cgctcccaaa taataacgta acgatgatga tagatgcaac tacgccgatt 1978081 aaatctgcaa gaagtcccac ctttaatgca tcacccattt ttttaatgcc gactgctccg 1978141 aaatacacag tcagtacgta aagcgttgta tctgtagatc cctgcatgac ggaagccagc 1978201 ctgccgataa aggaatcggg cccgtatact gcaattaaat cggtcgtcat tccaagtgcg 1978261 gccgtaccgg agatcgggcg gatcagagca agcggcacta cttcagcagg gatgccgata 1978321 gcggagaaag ccggttttaa aagatccatt ataaaatcaa gcgcgcctga tgatctgaaa 1978381 acagttatag cgacaagcat tccgactaaa taggggataa tggaaaaggc aatttctatc 1978441 ccctctttcc cgccttcgac aaacgattca tatgtcggaa cctttttgat cgttccataa 1978501 agaagaattc cggcaataat gattggaatc atggctaaag acagccagtt gatgatttcc 1978561 atccgctcac cttcccttct ttttgcggcg gtaataaaaa taccgatcaa tgataatggc 1978621 accgattccg gaaataagcg ttgccaaaat gcttggcccg acgatatctg tcggcgtttt 1978681 ggaggaataa gccattcgga cagcgatcac cgttgtcggg atgagtgtga tgcaggacgt 1978741 attaacagct aaaaaagtaa tcatcgaccg gcttgcttcc gatcggtttc cgttcagctt 1978801 tttcatttgt tccattgctt taatgccaag cggagttgct gcatttccga ggccgaagaa 1978861 attcgccata agattagata aaatatagcc catcgccggg tgatccggcg gtatatcagg 1978921 gaacagttta gatataaaag gtctgcacat ccggctgaaa atatccaaaa gccctgactg 1978981 ctcggcgatt ttcattaagc caagccagaa aacaagcacg ctcatcaatc caaatgagat 1979041 cgtaatcgct tctttcgcac ccttaaacac ggcttcattt acatcttgca gagttccgtt 1979101 gcacatcgca aaaacgagtc cgatcacggt taaactgacc caaattatat tgaccatttt 1979161 gctccgcctg ccgcattcag aaagattgat ttaaacgttt caaaaaattg tttcttcggt 1979221 ttttgatgcc gctcattttc ataatagatc ggcacttttg cgatggttgc atcgttgaac 1979281 atgatctcca tgtgccctac gatgtcaggg attttcgagg catctttttc ccatgctttt 1979341 ttcggcttga gcagtgtggt attaattttt acattttctt tttcctcttc ggtcagcaaa 1979401 taggtgatat cacgtttgat aaaagccttc gattcataaa atgtgccttt cagctttgga 1979461 atatcccctt tttttgcaat taaataggtt tgataatgct caaacacata gttaaacatc 1979521 ttcatatggt catcccaatc attagggtca ttaatggtga cggctatcag gtcaatgccg 1979581 tcctttgaag ccgtagagac cagtgtccgt tttgcaagtt ttgtatagcc tgtttttcct 1979641 cctgtgctgt acggataaag catggtcagc agtttgtttt tgtttttcca tacgctttcc 1979701 atcgtttccg ctttgtatat ttttgtgcct gaaatctttt gatagtcttt cagcttcata 1979761 gcatacttag ttaaaatggc catgtcatag gctgttgaat aatgattttc atggtcgtcc 1979821 aatccgtgcg ggttttgaaa acgggtgttt ttcataccaa gctgctcggc tttttgattc 1979881 atcatataaa caaacccatc gaggctccca ccgacatgct cagcaatcgc gacagcggca 1979941 tcgtttcctg atcttagcat caggccatac acaagatctt tcagcttcac tttttgacct 1980001 tctgttaaat aaatggcgga gccttctgtt ctgacagcat ttgccgaaac cgtcactgtt 1980061 tgatccattt tgccggattc gatggcgagg acggcggtca taatttttgt gatgctcgcg 1980121 atccgccttt tttgatgctc atccttggca tataacactc tgcctgacgc accgtcaata 1980181 atgatcgcgc tttttgcact gacatctata gcagcatgtg ctgtattcac atttacggtt 1980241 gcaataagaa aagaaatcat gatcacgaat actgcttttt tgaaaatgcg catgtttgct 1980301 cacgtccttg tggtggtttg tacaagttta tgcgcatgtc catcagttat gaataacaat 1980361 tatatttctg gaagcaaaca taaaaaaact ctccctgaaa aagggagagt aaacgttatc 1980421 tgattggcgc catgcttgat ccggacgctt cgtaatgagc cagctcttcc ctcatcttca 1980481 gaaaggccgc gctcaacggc aataataatt gctcaagcga cgcaggaaca gcatgataaa 1980541 actcaattgc gctgaccccg gtataagacg cccggctatt ttcacaccac gtgtcttttt 1980601 tcggcataaa gaactcttca atgcattggt gatacacatt ataaagtgtt ttttccgctc 1980661 tggcttcctg aaaaggctcc tgcatcagga gacgacggca cgcttctgcg cctccttcac 1980721 aaaatactgc cattcttctc agagtgctaa gcacatcaca gcagtatcct ttttcaatag 1980781 gcaattcagc ctgtaaggac tcaagcgtcg tttgatttag gtaatcgttc acggtattga 1980841 caaccattga taagaattcg cctgtttttt gagtctgcgc tcgcacaatc gaatgtccca 1980901 tttcgtttgg tatcttcccc tcatgtattt gtctctcaca ttttgcttct ttcatgatag 1980961 cttcttcctt atatcttatg atgatgaaaa agcgcgattc attaaacttc tattttatat 1981021 cttcgaaggt ttggttaaag ttttcaaaaa ataaatctgc ttcttcttga agaacgtctt 1981081 cttccgcatt ttcaggcagc ggcggaagct cgtccagcgt tttcagaccg aattgttcaa 1981141 gaaaagtcgg cgtagtaccg tataaaatgg cccgccccgg accatcggca cgccctactt 1981201 cacacaatag cgccttcgcg acaagactgt gtaaaatccg ctctgatttt actcctctga 1981261 tttcttcaat ttctgctctc gtaattggct gtttgtatga aacaatggcc agtacttcta 1981321 aagatgcttg agaaaggccc tttgacggca cttcaatcag ttttttcaag taaggcgcaa 1981381 agtctttttt ggtagagagc atgtacgtat ctgcatactc aataagttca atccctcgtg 1981441 tatctccgcg gtattcgtcc gccacatccg ccatgatcgt gttcagttca ggctcttcga 1981501 tttcaagcac tgttaacagc tgcttttttg taagcccttc atcgcctgcc gcataaagaa 1981561 gggcttccac aatagctttc caattcacga tatcaagccc catgaatgga ttcactcccc 1981621 gtaatgtaaa tatctgaaaa attgtgctcc tgttcaatga ggaccagctg atttttcatc 1981681 agctcaagaa cagctagaaa ggtcactact aaatgttctt tttgctcata tggaaacaga 1981741 tccataaagt taattctcgt tcctctagat ttcaagctgt gcacgatttc gttcattctg 1981801 gcttcgattg gtatgtcctg tcttgtaatt gttgtttcca tcggcctgtt tatttttttg 1981861 cgtttcagca ctttttgaaa agctccgatc atatcataga ccgtgacaga gagcttttgc 1981921 tcagactgtt ttacttcttt tgcatattca ctcaaatcac tcggcggttt cgtgaacgat 1981981 ttttgtcttt cttcttcccg ttcttttaaa tccttcgccg catctttata ttttcggtac 1982041 tcaatcagct tttcaatcag ttcctcccgc ggatcttctt cttcaagtaa ttcatcttca 1982101 aaaagctcct cctcttgctt cgggagcagc attctgcttt taatgctgag cagcgtggca 1982161 gccataacca aatactcgct ggcaatgtcg agctcaagca cgcgcatcgt atgtacatat 1982221 aataaatatt gttcagtgat cttcgccaca ggtatatcat atatgtcaat ttcaagacga 1982281 ttgattaaat gaagcagcag gtccaatggg ccctcaaacg tatcaatttt cacttgatat 1982341 tcttccatca tctcaccatt ttcaagtatc actctcattg ccggaaaaac tggctaccct 1982401 atagtataag ccaccaaaaa gctctcgtcc aatactattt catatcctgt tttgaaggag 1982461 tttgtacaga atattcaaaa cacaagaggt gtttgctcgg agcgcagaag cgggagaaaa 1982521 agcctttgct tctggttttc ctttctaaga agcactagag gccgggcgtt cttttttcct 1982581 tttatccctt ctatggtaca ctaaaagcac attaaaggag gaagcacctt gtatccgaaa 1982641 gcttatatag attatctcgt tgagtttcat gcgacacggg attattttga atgccatgaa 1982701 atattagaag aatattggaa ggaagatccg ccaaagaaac gaaaacgcta ttgggtgggc 1982761 tttattcagc ttgcagtggc tttatatcat cacagaaggc agaatacagc cggggcaaaa 1982821 agactgatgg cgaacagcat ccggattctt caagcagaac accgggcagt cgaagactta 1982881 gggcttgatc atggccgttt gctcgaactt atgcaatcgg tttacgaaca aatcgaaacc 1982941 gtctctgcct ataaaagcat tatactgcca atcaaagatg agaaactgga ggaagcatgc 1983001 aggatcgaat gcaggaaaaa aaagtataca tgggggcagc ccagtgcact cagcaacata 1983061 tttcttatcg acaaacaccg tttgcgggat cggactgacg tcatccgtga acgtgaaaaa 1983121 gaaatagaac gcagaaaaaa aagcagagac tgatcacagc ctctgcttaa ttattgtatg 1983181 aaatgtcttg atcctgctga ccttgacaac gttcgaaaaa gctctgcgtt aattcatttg 1983241 gaaccagtac ttgcgttttg aataaatgct ttaaagcatc catcatctgt tttccgattc 1983301 cttgatggcg atgagaagga ttcacactga tatgccggat ctcaacctca gaatcctttt 1983361 tttcgactcc gattgctccg acgatatcct cgtcctcttt ccaaagaaag agctggcggt 1983421 ctgtatccgt ttcgtagtcc ttaattgtct gctgaagctg cttaaggtct ttttcattcg 1983481 gcataaacga aagaagcccc atcgcaatct tttcaaacga ttttttataa cgaattaaca 1983541 taaaaacccc tctatatcca aaatgtccag tctgctatta acggatacga ataggtgatc 1983601 cgttttctca cattatatca ttttcgccat atttttaaac tgttttcagc aaattattca 1983661 aatgagcggt ttaaatttgc catttcaatg gcagaaacag cacaatctac acctttgttg 1983721 cccgcttttg tgccggcacg ctcgatagcc tgttcgatgt tttcagttgt tacaattcca 1983781 aagatgacag gtacaccagt agtgtttgct gcttgcgcga tgccttttgc agcttcattg 1983841 cagacataat cgtaatgtgt cgttgcgcct ctgatgacag tgcccaatgt gataatagca 1983901 tcatattttt ttgtttccgc catttttttc gcagcaaacg gtatttcaaa tgcgcctgga 1983961 acccaagcca catcaatgtc atttgtgtct acgccatgtc tgagcagcgc atcttctgct 1984021 ccgctcagca gcttgctcgt aataaaatca ttaaatcttc ctactacgat tccgatttta 1984081 agacctgtac caactaaatt tccttgtatg atattcatat gattcccatc cttttttgtg 1984141 atatttgtga ttagaaatga agtaaatgac ctagcttgtt cattttggtt tgcaaatatt 1984201 ttttattgtg ttctttcgcc tccatttgaa gcggcactct ttctgaaata ctgagtccgt 1984261 agccttcaag gcctgcgatt tttcgcggat tattcgtcaa aagcttcata ttccggacac 1984321 cgaggtcgcg taaaatttgt gctccgatgc catagttgcg aagatccggc aagaatccaa 1984381 gcgcctcatt ggcttctacg gtgtcatagc cttgttcctg aagcttataa gcttttaatt 1984441 tattgattaa accgatgcct cgtccttctt ggcgcaagta caggagcact ccacggcctt 1984501 ctgcggcaat ttggttcagc gcggcgtgca gctgcggtcc gcaatcacag cgatgagagc 1984561 caaacacgtc acctgtgaga cattctgaat gcacccggac caataccggt tcttctccga 1984621 acggcacatc tcccatcaca aatgcgacat gctcttttcc atctacctca tttgtgtatc 1984681 cataaacctt aaatgtccca aaatcagtag gcagcgtaat gtcaacttca cgctcgacaa 1984741 gtgttgtcag attgtaacgg tattgaatca aatccttaat ggtgatcatt tttaattgat 1984801 gctttttcgc aatttcaatg agctcaggca ctctcgccat cgttccgtct tcattcataa 1984861 tttcacaaat gacgccggct cctggagatc cgcaagcttc agcaagatca acagcagctt 1984921 ctgtatggcc cgctcttttc aggacacctc cttttttcgc aatcagtgga aaaatgtgcc 1984981 ccggacgctg aaaatcagat ggcacggatt tgctgtccag caatgcttga acggtaaaag 1985041 atctttcttg agcgctgata cctgtcttcg tttcacgatg gtctatgctt acggtaaatg 1985101 cagtgtggtg agagtctgta ttatgctcaa ccatagggtg aagatcaagc ctgtctgcga 1985161 tttcctcact gagcggcgtg cagatcagtc ctctcccatg tgtcgccata aagttaatga 1985221 cttccggcgt tgcatgctcg gcaagagcca caaagtctcc ttcattttct ctgtcttcat 1985281 catctacaac gatgatgact tcgccttttt ttaaagcgtc cagtgcttct tctatcggat 1985341 gaaacatgca aatcttcctc tctaaaagcc gttttcgctt aagaaggctt ttgtaatggt 1985401 ttgttgggtc ttattttcat tggctttatg caaaaatcga tacatatatt ttccgatcat 1985461 atcgcattcg atattcactt tagagccgat cgttttttct gaaaagatcg tttcgctgat 1985521 cgtatgcggt attaaggaga tcgtcactgt gtcttctgtc aggccgaata tggttaagct 1985581 cacgccatcc acagtaattg atccctttaa aaccaatgtt tttgttaatg acgggtccat 1985641 ttttaaatca tagtaaactg cgttgctttt ctcttcaatt cgtgtgattt ccgcagttcc 1985701 gtcgacatgg cctgagacga aatggcctcc gaaacggccg tttgccgcca tcgctctttc 1985761 cagatttact ttgcttcctt ttgttaaatc attcagtgac gtagctttga ctgtttcagg 1985821 cataacatcc actgtgaatt gattttttgt aaaatcagtg acagtcagac aaatgccgtt 1985881 cactgcaatg ctgtcgccaa gatgaacatc ctctaaaatc tttgagcatt taatagttaa 1985941 ggccattgca tgccctgctt ttttcatgga ttcgattgtg cctgtttctt cgataattcc 1986001 tgtaaacatg gtcaccatcc tattcctttg tcggttttgc cgtcagtttg atatcacggc 1986061 cgatttgggt tatatcagtg aattgtaata aggggacatc tttcattgat tgaaaacctt 1986121 caccggagat taagctggga gcatgcgttc ctccgattag tttaggggca aaatagaaga 1986181 tgatttcttg aaaacagcct tctttgacaa agcttccgtg aacagctgaa ccgccttcca 1986241 catacaccga catgatgcct tcttccgcta ggatcttcaa aacatcagga atttgaatgc 1986301 gctcggtttc aagtgtaaat atgttcactc cgaaagctga aagccgtttt ttcttttcct 1986361 cgtctgcgcg tgccgtcgta aaaatccatg tcggcgctat ttgatcgcaa atcactttag 1986421 cgtcctcagg aatcgagagt acggtatcaa gtatgacccg aaccggctgt tttgttacat 1986481 tcggcagtct gcaggttaag ctcggattgt cggctttcac tgtgccaact ccgactaaaa 1986541 tgctttggtg tgttttcctg tattgctgag catcctgtct tgcagcctct gacgtgatcc 1986601 atttgctgtc acccgtgctg gtagctatct tgccgtcaag gctggcagcc gcttttagcg 1986661 tgacgtacgg aaggcctgtc ctcataaagt gcagaaattt ttcattcagc ctctccgcct 1986721 ggtctgccag gatgccttcc cttacctcaa tgccagcttc tttcatcatg ctgatccctc 1986781 ttccagccac aagcggatta ggatctctca tcgccacgaa cactcttttg ataccagagt 1986841 tgataatcaa ttctgcacat ggcggtgttt ttccgtaatg gctgcacggt tcgagtgtaa 1986901 cgtaaatgtc ggcaccctct gcatgtgctc cagccatatg gatggcatga acttctgcat 1986961 gagcttcacc atattttaaa tgggcgccca ttccgacaat ttgtccgtcc tttacgacaa 1987021 cagcgccgac gagcggattg gattcggtct gtccttcgcc ctgcttcgca agatctaagg 1987081 ccagcttcat ataatactct tccatttgtt tccctcccct cttttgttat ttaccgtcaa 1987141 aaaagccccg aatttataaa aaattcgggg ctttaggtat tttacgcaat aggaaataac 1987201 actatgcatt tttaaacatt ttgcatagcg gctcatcatc cttctcccat ccagactttc 1987261 actgtcggct tcagcttaaa ctgaatccac cgcgtgctta tgcacacggg tcacgggctc 1987321 taaagcaaat gtgctttact accgccggtc gggatttcca ccctgccccg aaggatacaa 1987381 tctttattca tttgtcctta ttggttatta tagcgatcct ttttaaagta cgcaatgaaa 1987441 taaacttaca atttgagaaa aacaaaacat cacccttcga tccgaaaggt gatgtttttt 1987501 aatcattcac ttttgcaacc ttgattaatc cgtcgatccg ctttgatttg ctgaagtaag 1987561 ccttaatctt gtcaccttct tttatatcag ataaatcctg atttaatttt tttccgttga 1987621 agatgatttt cgttccgttt tctgctactc catgatactc tgagccgtca attttcgtca 1987681 ctttatattc ctggatggtg tattcctctt cttccgagga caaggtttgt ccaattgctg 1987741 tcggaacatc cttcagctca atatcattta tgtacatata accgcctgca agtaaaagca 1987801 aaagcactaa cagaatggta atcttggttt ttattcttcc catttctaaa cctccagcca 1987861 atatgaatct attcattcat atgagttatt cctttttttc atgaataaaa aaccgtaaat 1987921 tctcgtaaat tattaatata acgatgcata acgggaatat gtttcacatt tctgcaaaaa 1987981 tttcttttct atagatatac gaatttatgt tctgttttta ggggatgacc gtaaaaaaga 1988041 tataaaaaaa gcagccccaa tgggaagctg cttgatccta atttgttttg cgcatttcgt 1988101 taaacgggta gaaaacaaac tttgacgtac ccgcaatttg ttttttcgtg aagaggccaa 1988161 ggccgttacg gctgtccatg gaattgcgac gattgtcacc catcacaaaa tacttgttat 1988221 caggcacttt aaccgggccg aaatcatcgg tcaaatggtc aaaaccgtcc tgtttcgctc 1988281 tctttttatt agccgccaaa taaggttcgt ccaccttttt cccgttgata tagagctggt 1988341 catttttcat ctcaaccgta tcgccgggaa ggccgataat acgtttgaca tagtgaacat 1988401 catctccgtt taacacgacg atgtctcctc tatcaaactc gccgatgtat ttgactgtca 1988461 tattaacaaa aaccctttca cggttgtgaa gtgtaggata catagagtca ccatcaacga 1988521 catacggcgc aaaaataaag ttgcggatga gcaaagcaag aacgacagca atcacaattg 1988581 cttttgccca ttctaatatt gactttttct tcgaaacatt ttctgatttc aactgatttc 1988641 ctccaataaa caacggtctt caatttatgt tatcacgaat cgaaaaaaaa tcccattagg 1988701 accattgaag tgattttaca aactgttaat cttcatcttc tacccacatc atgcctattt 1988761 tttcttgtcg atcataacta ggcctgaaaa tattgaaaga aatgaatcgc ataattcaga 1988821 agcgatggac tcagaagaaa gagagttctc atatgcaaaa tctttagatc gtatataaag 1988881 catgaggtta cgggcagttt gttcatttac tgcattccat tgatctccca gtccatgata 1988941 cccatggcac ttgacaaaac aattaacgtc atgaaggtta ctggaatgtt tgcggcaacc 1989001 tatttcacag gtgataaccg caccccgttt tttgctttca taatatgttt aaaatcattc 1989061 aagctcgaaa acatggatca gcctccaaaa aataaatcca atatattccc ggcagttgaa 1989121 gactctttat tataaaactc tgaatatccg cagttcttac agtaaaccac tagaaatcgg 1989181 ttatgctgca cgtcaaacag ctttgataat cccgtgccgg ttgtagctat ttctttttgt 1989241 ccggcttcag tactaccgca ttttatacag cctttgttgt tcatatcgcg atctcctttt 1989301 cattacatca cgtttgtttg atttatttta ctacaaaata tcaatcccaa tgacccgtac 1989361 tactttaaag tttacttaat tttgattaca tactaattgg gttcgtttct cagcttggta 1989421 aatcttctgg agaaacggaa aagctccatg accaaaacat tcaaactcag ccaaacaccg 1989481 ccgaaggcgt aacccgcagc aacatcactc ggatactgct cataaagtac acacggctca 1989541 gcccgatgag gaataaaacg ataataaaca aaaaaatgca acagtttgca gacgcgtctt 1989601 gtgagaatga cgaacaaaaa gataagcaca aaaaccaaaa atgacaaatg ccgttaaagt 1989661 ctgttcgctc gggaatggat ataatacatg actttccaaa ggagcgtgaa caggatgaag 1989721 ggaatgaaag agccgtctga ttccctcttc ataaagctcc ccaccaatga ctaggaaaaa 1989781 taagaaagag agttcgattt tccgatcttg ccctctgaat accgtccaaa aaaaagttag 1989841 aacaataacg gctaacagaa cacctctcga cgcaaaagct ttctgaattg cagctgggcc 1989901 cagtctatac ccgatccaat acgacatgct cactcccaca gctccccaat ccggccgcta 1989961 acatgcttag cacccagttt aacttttctt gaaacacgag aacaccggca aactctcccg 1990021 gtccaagtaa agctagaagc tctaacatca agacaataaa caagacggca tatccgtact 1990081 gttcgagcaa ccccgtcaaa acttgcatgt gattctcctt aaactttttt gttcttttat 1990141 cattcccaat ccactttttg tataatcagc acaattttat cttcagtcgt ccaacaacat 1990201 tgtctatggc gggatcttct ctcatacatt cttttttgac ataggaggag caatagcatg 1990261 aaatgggagg aaacaaaaga tacgcaggga gtttgccaaa attttgggca gttcgttctg 1990321 ccaccgagtc aggtgtttgt ttgcccacct catcccttgt caattcccca tttttcccgt 1990381 ttgaggttcg aaatggtaaa gtatttcact tagtttctta catgaagagg taaattcttt 1990441 gctcaccgaa ctaggatagc ggcgtatggc gatttctaca ttgcataacc actggttatt 1990501 tagtgagccg tgagcaatgt atatgcactt tgagtcagca caggatgatc ctattacatt 1990561 cgccagaaaa gcagctgccg cattcagagt agttaaaaga atagacagat atctgggctt 1990621 ccggaagctt taaaggaggc tcttttttcg agcattttta taaatcaata aaaacaggca 1990681 tctcctaaat atttttgccg ataagtttac gctaatcaac tctagcacta atacatataa 1990741 aaaatagaat gatatgaaag gagacttgat agtatgattg attatcctat taatataaac 1990801 aacgtttccg ggaacagtgt aattaacgta ggcggcgctt ttatgatcag gcctttaact 1990861 ttgtccaaat ctgtgtttgg ctccggaggt ttaaacacag gaattgtctt tgaaaataac 1990921 tttgtaagca aagctaaaat gattaatcat caatttactg atcaaaacgt caccaaaact 1990981 ttttaatgta ttcaatacac gggggtcact aactaaacac ctggttttgc caaccgccat 1991041 cagcattcgg cggtttttta ttgaacattt ttggccaata aaaaaagctt cctctctaag 1991101 aggaagcctt ttgcctgccg attagccttc tacacgaact tctttcatga catcgccatt 1991161 agacatgttt ttcgcgaatt ctaatccgct tgttacttta ccaaatacag tgtgaacacc 1991221 gttcaaatga ggctgtggct catgaacgat gaaaaattgg ctgccgccag tgtcttttcc 1991281 ggcatgtgcc atagaaagtg cgcccgcctc atgtgtatgc gggttgcctt ctgtttcaca 1991341 tttgattgtg tatcccggac cgcctgtacc agttccgtgc gggcatccgc cttggctgac 1991401 gaagccaggg atcactcggt ggaatgtaag cccgtcataa aagccttcgt tcgcaagctt 1991461 ttcaaagttt gcaacagttc caggtgcagc ttcaggataa agttcaaatt caattttgtt 1991521 cccgtcttct aataaaaagt aacctgtttt caattgtatg cctactttct ttattttaat 1991581 tttcaaagga gattatgtat aggttatagc ctgtctctcc ttgtcgcggc tattatacca 1991641 cacctttcgg gggaaaacga atctcccgag ctttactaaa aaataaaaat gaaacctgaa 1991701 tctctttatc tccgtctaac ctaacggaac tgtatttttc atgattcagg tcctcacaaa 1991761 gcagcactat ccagctgctt gtgaaattga aggaggtcaa actgctttga agaaaatttg 1991821 gattggaatg ctggcagcgg ccgttttgct gctgatggtt ccgaaggtca gtctcgcgga 1991881 tgccgcagtt ggagatgtca ttgtaacact gggtgctgat ttgtcagaat ctgacaaaca 1991941 aaaagtgctt gatgaaatga atgtccctga taatgccaca acggtaaccg tgaccaataa 1992001 ggaagaacat gaatatttag gaaaatatat atcgaacgcg caaatcggat cgagagcgat 1992061 ttcttcatcg tcaatcacca ttgccaaaaa aggctccgga ttgaatgttg agacccataa 1992121 tatcagcggc atcacagatg aaatgtacct gaatgcactg atgacagccg gtgttaaaga 1992181 tgcgaaggtg tatgttacag caccgtttga agtatccggg actgccgctt taactggatt 1992241 gattaaggcg tatgaagttt cttctgacga agcgatctcg gaggatgtta agcaggtcgc 1992301 caaccaagag cttgtcacga catcagagct tggagacaaa atcggtaacg aaaatgcggc 1992361 agccctgatt gcaaaaatca aagaagagtt tgctaaaaac ggggtgcctg ataataaagc 1992421 tgacatcgaa aaacaagtgg atgacgcagc ttctgattta aacgtcacac ttacagacag 1992481 ccaaaagaat cagcttgtct ccctattcaa taagatgaaa aacgctgaca ttgactgggg 1992541 acaggtcagt gaccagctag ataaagcgaa agataagatt acgaaattca tagaatcaga 1992601 tgaaggcaaa aacttcatcc agaaagtcat tgatttcttc gtatctatct ggaatgcgat 1992661 tgtatctata ttcaaataag aaaagcgccg aaaaatcggc gctttctttt attgctttac 1992721 acccgtttta aatggcagat caagttttac aatatcttcg tatgtttctc gcttcacgac 1992781 taaatgagcc tcaccgtttt cgacaaatac aacggcgggt ctcggaatac ggttataatt 1992841 gttggccatg ctgtatccat aagcgcctgt acaaaaaacg gcaagaagat cgccttcttt 1992901 tacttccggc aggtcaatat cccaaatcag catatctccg ctttcacagc actttccggc 1992961 aattgatacc gttttgtcat gcgcttctcc gatcctgttg gctgccgcag cttcatattt 1993021 agcttggtaa agcgcaggac gaatattgtc gttcatgcct ccgtctacag ccacatattg 1993081 gcggacaccc ggcacttctt tttgagagcc aaccgtataa agagttgtgc ctgcgtctcc 1993141 cacgagagaa cggcccggtt cgatccaaat ttccggaatg tcaaaaccgt aacgggaagc 1993201 attttctttc acagcttcga taattttttc aacgtattca gtggcatgaa gcggttcatc 1993261 atcttccgta taacgaatgc cgaaacctcc tccaagattc agcaccttgg atacaaatga 1993321 atatgaatct ctccattcgt ctagtttttt gaagattttt tccgctgcta acacaaaacc 1993381 ggccgtatca aagatttgcg agccgatatg gcaatggaca cccagcagct gaatgtgttc 1993441 cgattgtaat acttgttcaa tggcccgttc agtttgtccg ttatgaagat cgaaaccaaa 1993501 ctttgaatct tcctggcccg ttgtaatgta gtcatgcgta tgcgcttcta ctccgggcgt 1993561 gatccgaaga agaacatcga tggagtgacc cgtttcttta cataggtctt caagaagcgc 1993621 gatttcatag aaattatcca ccacaatgca gccgatgcgg tgctcaagcg ccatccgcag 1993681 ttcttccctg ctcttattgt ttccatgaaa gtggatgcgt tctgccggaa agcctgctgc 1993741 aacagccgta tatagctctc ctccggatac gacatctaaa gaaagtccct cttcctcagc 1993801 gagctgaatc attgcgactg atgagaatgc tttgctcgca tatgccacct gtgctttcag 1993861 ccctgcagaa ataaacgcct gcttaaagct tttagcacgc tcacgtatta aagccacatc 1993921 atatacgtaa agaggtgtac catatttctc cgctaaatag agagcatcca cacctccgat 1993981 ttctaaatga ccatgttgat tttgtctgct tgtgccgtgt aagaacaatg tcattccctc 1994041 tttctccgct tatggatgaa aggacagttt tatggactgt cccttcataa ttaagacata 1994101 cattatcata ctcttcagtc agtttcaatg cgattatgaa ttggtaggct gccttaagcg 1994161 atttttgggg tgaacgatgc tgggtcttac ttttgcgcca ggtttcgctg tgcggacaag 1994221 aacctgccac agcgcctttc cgttaaaggg aatcagcggc cataagtacg gtgtctgaag 1994281 ggatttgatg cttgccatgg caataattag cactgtaaat ccgatgacga gcccttttat 1994341 atgaaataaa gcaacgagta tcatgaggac aagacggctc attttgtttg ccaagcttaa 1994401 ttcataacta ggcgtcgtaa aggttccaat cgccgcaagt gagacgtaca gaatcacctc 1994461 aggagaaaaa aggccgacct caatcgcaat ctgcccgatc agaacagcgg caattaaacc 1994521 cattgctgtc gataaagccg tcggtgtgtg aatggcagcc attctgagaa actcgattcc 1994581 taagtcagct aaaaatatct gcaggatgat cgggatatgc gtatctttat ttaaaccgat 1994641 aaatttcatg ttgtccggga gcagatcagg ctgaagcaca aagagaaacc agatcggaag 1994701 aaataaagta gaagcaagaa taccgaaaaa tcttacccga gctcgtggtc attcggcata 1994761 attacttaaa ttttgtccag tctcccatcg tccgctttaa gaatgtgata aacccggctt 1994821 tcttcatatc ttcttttgca gcaacaggac tttcagcgag tacttctcca tcctttttca 1994881 gaacaagagt gccaagctct tggccttttt gaatcggagc actaatattg tccttcatct 1994941 tgatttcttt tttcacatcg ttcatatcct cgcctttttt cgtcaatatt gaaatcggct 1995001 cagatgtagt gagttcgata aatttttgtt tccctttttt gacctttact tttgctactg 1995061 tttgatttcg tttatataaa ggatgcgttt catattggct aaaggcgaag tcaagcattt 1995121 ttgtcacttg cgcgtttctt tctttaggcg tgctcgctcc gaatacaacc gctatggccc 1995181 gcatgtttcc ttttttagcc gaagcagtca gacaatattt cgcttcgcct gtatagcctg 1995241 tttttacgcc gtctacacca ggataaaatt tgataaggcg atttgtattt acaagccaaa 1995301 actttttatc tgtattttca cgcagataat cttcatacgt gccggtaaac ttcgtaattg 1995361 attcgtattt caataattcc ttagccatga ttgccatgtc ataagcagag ctgtagtgtc 1995421 cttcctcggt cagtcctgtt gggtttttaa aggatgtatt tttcaatccc agctcttttg 1995481 cttttttatt cattttcttc acaaattctt cttcagagcc ggaaataaat tcagccatgg 1995541 cgacggaagc gtcatttccc gaagcgattg cgatgccttt cagcatttct ttgacagtca 1995601 tttcttcgcc gggctcaagg aatatctgtg agccgcccat tgacgccgca tgctcgcttg 1995661 tacggacctt atcactcatt ttgattttgc ctttatctaa agcttccata atcaaaagca 1995721 tcgtcataat tttcgtcatg cttgcaggcg ccagtctctc attgctgttc ttgttgtaaa 1995781 gcacttttcc cgtgtcacgt tctatcagca ccgcagactt cgcttcatga gcaagctccg 1995841 atgtacgttt tccgtcttgt tttgcaaatg cagacggtgc aaatgtaagc agcattatac 1995901 caatcaacaa agtggataaa agacgtttca tctcaaaagc cctccatttc ataatccttt 1995961 ttattttttc caagcgtgat ggttttatac gccactgatg gaaaatgttt cgaattttgg 1996021 gcataaaaaa agacagctgt gtgatatcag acacagctgt cttttggtcc tgcattgatt 1996081 catatttatt cgtactgagc gacgatcgct ttaacaagct ttaagaatcc agcttttact 1996141 ttttcggtca cttccataac ttcatcgtga cttaaaggct gatccagaat tccggctgcc 1996201 gcgttagaga tgcaggaaat gccaagaacc cgcattcccg catgattcgc tacaatgact 1996261 tccggaacag tagacatgcc gactgcatca gagcccatcg ttcttaagaa acggacttct 1996321 gccggtgttt cgtaagaagg tcctgtcaca gcagtgtaca cgcctttttg aattgggata 1996381 ttaaggtctt tcgcaatctt ttcagccagg ctggacagat ctttgtcata ggctgaagac 1996441 atatctggaa atctggcgcc gaaatctgct tcgtttggcc cgattaacgg gtttgttccc 1996501 ataaagttga tatgatcggt aataatcatt aaatctcccg cacggaattc agtgttgaca 1996561 ccgcctgcgg catttgtcac gatcaacgct tccacaccga gcgctttcat cacgcgtaca 1996621 gggaatgtga ctttctccat tgagtagcct tcataaaaat gaaagcggcc ctgcattgca 1996681 atgacggaaa ctccttcaag agtgccaagc acaagctgtc cggcatgccc ttcaacagta 1996741 gataccggga attcaggtat atcttcatat ttcagcttga ccggattttc gatttcgtcc 1996801 gccaaaatgc caagacctga gcctaaaata aggccgatct ttggagattc cggcaggttt 1996861 tgtttaataa aagcggctgc gcgttcaatt ctgtccttca agaaacagtc cccctattgt 1996921 aataaagata aaaagctttt cccgtatttc ggtttatttg tttggaaatt atcagcgatc 1996981 gttgcgccaa tatcggcaaa tgtatctgca agcggcagca tttgcgcttt cttatgtttt 1997041 ttgctgtaag cgagaatcgg cacatactcg cgtgtatggt cagtcccatg atgaatcgga 1997101 tcattgccgt ggtcggctgt aataattaac agatcgtctt ctctcatttt ttcaaacact 1997161 tccggaagcc gcgcatcaaa ttcttcaagc gcgcgtccgt agccttcagg gtcacggcgg 1997221 tgtccgaata acgcgtcaaa atcaacaagg ttcgcaaagc tcagacccgt aaaatcttct 1997281 cccagcgtat cgatcacctt gtccattccg tccatattag aaaccgttct gcgtgaagaa 1997341 gtaatgcctt ctccgtcgta aatatcagag attttaccga ttgaaatcac atctaagccg 1997401 cagtctttca attcattcat gacagtgcgg tcaaacggct tcagcgcata atcatggcgg 1997461 tttggcgtcc gtttgaattg acccggctct ccgacgaacg gccgtgcaat aatgcggcca 1997521 accatatatt tcggatcaag cgtcagctct ctcgccgttt cgcaaatgcg atacagctcc 1997581 tcaagcggca caacctcttc gtgagcggca atttgcagaa cagagtcagc agacgtgtaa 1997641 acaattaaag cccctgtctc catgtgctcc tggccaagct catccaaaat cgctgtgccg 1997701 gaagccggct tgtttccaat aattttgcgg ccagatctct tttccagctc ttgaagcaat 1997761 tcatcaggaa agccttccgg gaacacttta aacggtttat caatgtataa acccataatc 1997821 tcccaatggc cggtcatcgt atctttgccg tttgacgctt cttgcatttt tccataatag 1997881 gcaagcggat gttctgtttt ttctacacct ttgatatctt cgataagacc aaggccgagc 1997941 tttgccatat tcggcatatg taatccgttc atatgctcgg caatatgacc gagcgtatga 1998001 gcgccttcgt cattaaagtc agcggcatcc ggcgcttcgc cgattccgac tgagtccatc 1998061 acaattaaaa acacacgatt atatttgtat gcaggcatct tgaaagcctc ctttttttct 1998121 atacgtctat tgtatcgcta agaggtctga caactcaagt ataaaccgtt ttcattcccg 1998181 ttgacaatgt atttggaaat aatgagaaac ttcaatattt tctgtcgctc taaacaaaaa 1998241 agccgcagcc acctgcggct atgctcgcgg atgaaactgc ttgtacacat ccttcagcct 1998301 tgttttcgtc acatgcgtat aaatttgcgt cgtggatata tccgcatgac cgagcatttc 1998361 ctgcaccgct cttaaatctg ccccgttctc aagcagatgc gtcgcaaagg aatgcctgag 1998421 tgtatgcgga gtcagctctt tcttaatgcc ggcttccaat gcgatttttt tcaggttctt 1998481 ccaaaatccc tggcggctga tctgtttgcc gtgatgattt aaaaagaggg cgtcagatac 1998541 attatttttt aacagttttc ccctggcttt tgtcatatat tcctcaatgg cggaagcagc 1998601 ggcttcaccg attggcacaa tccgttcttt tcttcctttg ccgaagcatc ggataaaccc 1998661 catagataaa tgaacatcag ccgttttcaa ttcaatcatt tcactgactc gtatgcctgt 1998721 cgcataaagc agctccagca ttgctttatc ccgatatccg aaagggctcg tcagcttagg 1998781 cgtgtccaat aaccgctcga cttcattgag cgcgagcacc ttcggaagcg cccgttccgt 1998841 cttttgtgtt tcgatatgaa cggaagggtc cttatccgtt actttttccc tgagcagaaa 1998901 ttgatgaaaa gagcgaatgg atgccaaatg ccgcgccgat gtcttgccgg atttccccga 1998961 gtccttcaaa tgctttaagt attggataat atgtatgcgg gtaacgtgat tccaatctgt 1999021 aacatgaagg gtttctgtta agtagagaga atagcttttc aagtcacgtt cataggatac 1999081 gatcgtattt tgagagagcc ctctctctac cataacgtag tggatgaaat cctttatttg 1999141 atctttcact cttgatctac tccccgtttt ggtaaaaaaa gatcaaccgg tcgaaccatc 1999201 cgcctttttc atcctgatcc atttcaacaa cttttacagc ggagccttcc ggtttatcat 1999261 accgatgata gttttcatac tcttgattca cccatatcat agcataatag aacaaagcgg 1999321 taaaaccggt aaacaggatg aaaactttca atgcatcgac agctgttttc aggaatcttc 1999381 ccatgtccta atcgatcctt tccctatggt tccagttata taaaccatat gccaaatcag 1999441 aaaggtttta tacatagaaa cagcaaaaaa ccctttcccc atgagaaaag gttcgcgctc 1999501 ggcaccgtct attcagtttc ttttccgtta cagcggtggc aaatgccgtg aaacgtcaat 1999561 ctatgatctt taatcttaaa tttccaatca cgttcaatga tttcttccac gtcttcaagc 1999621 aaatcttctt caatttcatc aacggctccg cactccatgc acaccaagtg gtgatgaaag 1999681 tgagctgcgc cctctttccg aaggtcgtaa cgggacacac cgtctccaaa gttaatttta 1999741 tctacgactt ttaattcagt taataattca agcgtacggt atactgtagc gagaccgatc 1999801 tcaggagatt tctcttttac gaggaggtat acatcttctg cgcttaaatg gtcttcttcg 1999861 ttttcaagca gcactcttac tgtcgcttca cgctgtggcg taagtttata gctggatgag 1999921 tgcagttgtt tcttaatacg atcaatacgg ttttccatgt ctttccctcc tacgccgcat 1999981 tccatgactc attataacaa aatacgcgca gagttccaac tataattatt ataaactgat 2000041 aaataaaatg gttttctttt aataatgatt ttaaaaaagt ctagatgtaa gcttttccat 2000101 taaaacagga gataagtatg cttcaaagag agatgaaatc agcgctaaaa acagaatgac 2000161 cagcagcaca aaggcatacc gcccgaacca ttgaatcggc gcgtcatgca ggcttcgttt 2000221 cacgaacagc tgtctgatta actttaaaga aaacgcaatt gcacatgtgc ccataatgag 2000281 ataagccgga atcagcagca cattttgcgg caaaacggag acaaatgata ggaaaaaccc 2000341 gcttactccc atctgattga ctaggaaccc gacagtaaag ccgacgacga tccctttcag 2000401 aaagatcata atgaaaataa tcggcatccc aatgacggaa attcccagta tccacatcag 2000461 gcctaaatac tttgcattat gaaagatact ttgcccaaac atatcagctg aacttgcctg 2000521 ttttccatcc gaaagctgtc caaaaaattg acttaagtag tagtataaat cttctttctg 2000581 gctgatggtc atactgttga caataatcgc gccaaagatg acacccatga aaaacagcac 2000641 tgacacaaat atataaagag agagatgatc tttgacatgc ctgagaaaca tgtccttata 2000701 agagattttt cgcataccgt ttcctcccgc ccgctctagt gatttgattt aatagattgt 2000761 atgaaagaaa cagaaaaaca tgcccttttt caaaaagaaa caatagagat gaatgctagg 2000821 cggctttttg gggcacaaaa aaatccttat catcaactgc tgtatgatca taaggattct 2000881 tatgcttccg tttattcaaa atctcttttt tgctttttgt cattcttcca tgtgtgctga 2000941 aagatggtgt gctgcctctt gataataaga cgtcacgtcc gccgtttctc aatcgatgcc 2001001 cccgcttctt tttcgcttgg ctttttgcca tgtgatcact ccctttttta ttttcatagt 2001061 aatgataaca aaattgaaca atgataagaa aaaaacagca cctgctacga caggtgctgt 2001121 ttagctacat ttatttcact gctgtaagag ctgcatgctc gacagctgct gctaccgcat 2001181 gatggacttt tgaatcaagc ggctgaggga caacatcacc ttgtttagtg caagctgcga 2001241 tggcctctgc tgctgcgaca agcatatcat gattaatctc cgtgcttttt gcgttaagcg 2001301 ctcctctaaa aatccctgga aaaccgagta cattattaac agaacgcccg tcagctgcat 2001361 atgcggcgcc agcctgcagt gcggcctccg gctcaatttc cggcttcgga ttcgataaag 2001421 ccagaatcac ttgaccagaa cgtacaaatg ccggttttat taaacccgga acgcccgttg 2001481 tagcaatgac aatatcacat gtttccataa gctcctcaat actggaaact gcctgtccgc 2001541 cgtattgttc gagacggttc attgctgact ctgatttgtc tgttccgtat acagcattca 2001601 caccataagc catgaacatc cggcagatgg ccacgcctgc tgcgccaagg ccgatttgcc 2001661 ccactttcgc ttccttcagg tcaacccccg cactcctgca tgccgaaatg gcagctgcca 2001721 gcgtcactac agctgtacca tgctggtcat cgtgcataac agggatgttc agctcctctt 2001781 ttaggcgatc ctcgatttca aaacaatgcg gcgaaccgat atcctcaaga aggatgccgc 2001841 taaagcccgg agaaatatgt tttactgttt tgatgatttc ttcaggatca ctcgtatcaa 2001901 gcagtatcgg aatgccgcta atacccgcca gctgatcaaa taaagcagcc tttccttcca 2001961 tgacaggcat gccagccaca gagccgatat tcccaaggcc taaaattgcg gttccatccg 2002021 ttacaattgc aacagaattg ctgatcgttg tataaataga agctttttca ggttcttttt 2002081 cgatcagtcg gcacacgtcc gcaacacctg gtgtgtagac acgtcccagc tctgccagtg 2002141 aacggatcgg cattttgctt ttcatttgga tttttccgcc ttcatgtgcg gacaggactt 2002201 catcagatac ggtgtgaagc ctgatccctt ctccgagggc ctgtacagcc gcgatcactt 2002261 cctgaagctg ttcttcattc tccacttgaa cggtaatatt ccgcattgtg taattgggtc 2002321 cgacttttac cgtctccact tcaccaatat ccccgcccag aaggccgatg gccgtagcca 2002381 cccttccaag atttccggga accgaaggcg tttcgatcat cagtgtccga atcatgtgtt 2002441 tcgctatcat tcagtgatcc tcccctatta gcctagtttt tcggctttaa ctgtattgtt 2002501 tttcgtatac catataaatt ttcctgtata accatagata attgcaagac ctattgctac 2002561 aaaactgagc cacataaacg gcagataaga gaaggtagaa acacctaaaa taccagccat 2002621 gtaaatccca ttatcagacc aaggaaccat ccccgaagtc aatgttcccc cgacctctga 2002681 gttacgtgat aacactcttc tgtccagatg taagcgatca tagctgtctt ccataatttt 2002741 cggagtcaaa ataagagata catacatcgc acagccgaag atgtttgcta aaaacgctac 2002801 gatcagtgta gacaatgtga cattgccggc tgaagttaat ttcttttcaa acgttgaaac 2002861 aatgactttt aacacgccga gtttctcaag cagaccgcca aaaccaaggc caaagatgat 2002921 gacgacgaga gaatcaagca taccgacaat tccaccgcgg tttaacaagc cgttcaaaaa 2002981 ttcaacatcc gttttaatag agaagccgtt gtacgcagtt gcaatcgcat gggcaatatc 2003041 cattccttgg aaaacaacag cccagattgc accgagtaaa gcgccaatta cgataactgg 2003101 catagatggc tttttcatcg ccaataagac tatgacgaga actgccggga tcagcatcca 2003161 aatatgaatg tcaaacgtgt tttgcaaaga tgattttaag aattcaactt tatcaagatc 2003221 aatatttttc ccgccgtaca taaatccaac aactgtaaag agtatagctg taatgacata 2003281 agcaggtatt gataaataaa gcattgctct cacgtgagcc aatacatcga cttttgatag 2003341 tgaagaagct agaactgtac tgtcagacag cggagacagc ttgtccccaa aataagcacc 2003401 tgaaagaata gctcccgcta ctagaggaag cggaatgcct aacccctctc caattgcgat 2003461 catggcaatg ccggcagttc cgactgttcc ccatgacgtt cctgttgcca cagacataat 2003521 ggaacaaata attaacgttg ccagtaaaaa gatacttggg tgaataaatt ccagtccgta 2003581 ataaatcaaa gtcggcacaa cgcctccggc aatccatgtt ccgatgagcg ccccaactga 2003641 aacgagaatc agtacggctt caaggccatt tgatatccca tgtacaatcg cattttgtaa 2003701 atctttataa gaataaccga gtctaatacc taaaagcatt gcaataaacc atgaaacaaa 2003761 aagcgccagc tgtatcggca agtcgagaaa gactgtaaac gatagaacaa gtgctaaaaa 2003821 tactcctagt acaataataa tttcaaatag tgttggcaat cttacatcct tcaaaagaag 2003881 tcccccttca tgtaaaagct aaaacgcttt caatatatag tgcaacacgt atactatact 2003941 tcctcatccc tatgttgtaa acagcttatt catccgacta ttcggagatg aataagctgt 2004001 attttataca aattttattt ttctaatagt tctttccctg cgatacctgg tttggtcatc 2004061 tcatatgggt ttaaaataat atccaattct tcttcagtca gcacatcatg ctgcagacaa 2004121 agatcccgga cagattgccc tgtcataatt gcttccctgg caattctagc tgccgcttca 2004181 tacccaagat gcggattgac agctgtgatc acgcctgcgc ttttttctac gtattgcttc 2004241 atacgctttt cgttggcttc aatgcctttt aagcagttgt cagtgaacga acggaagccg 2004301 ttgttcatga tgctgatgga ttgaagcaaa ttaaagacaa gcacgggctc catgacgttc 2004361 aactcaagct ggccggcttc tgaagcaagg cagattgtat tgtcatttcc gataacctgg 2004421 aacgcaattt ggttgatcag ctccgccata accggattga ctttccccgg cataatagat 2004481 gaacccggct gacgtgcagg cagagaaatt tccgcaagtc cggcgcgcgg tcccgacgcc 2004541 attaagcgca ggtcgtttgc gatcttcgac atgttcatca tgcagacttt taatgaagct 2004601 gatacctctg tataggcatc tgtattttgt gtcgcatcaa caagatgatc agcgccgaca 2004661 agaggaagcc cgctaatatc agcaaggtgc tttactacct gtttgatata ttcaggatca 2004721 gcgttcagcc ctgtaccaac agcagttgcg cccatgttga cttcatacag gtgctggcgc 2004781 gattgcttga ttcgtttgat atcacgctcg agaacacggc tgtaagcttc gaattcctgg 2004841 ccaagacgga tcggaaccgc atcttgaagg tgtgtccggc ccattttaat aacagagtca 2004901 aactcctgtg ctttttgctt aaacacacta tgcatatctt ccattgtttt cagcagtttt 2004961 tctaagagct tcaatgtgga aatatggata gcagtcggga acacatcgtt cgtagactgt 2005021 gacatgttca catgtgtgtt tggacttaaa tggatataat ctcccttttt atgtcccatg 2005081 atttcaagcg cccggtttcc gataacctca ttcgcgttca tgttcataga agttccggca 2005141 ccgccctgaa tcggatcgac gataaactga tcgtgccact tgccttccag aatctcgtca 2005201 gcggcttgta cgatagcttg gccaattcct tcatacagcc gtttcacgtc catgttggca 2005261 agagccgcag cttttttcac aatcgccagt gcgttaatca tttcctcatg gattttgtat 2005321 cctgtgatcg gaaaattttc agaagcacgg agcgtctgaa ttccgtaata aacatctgct 2005381 tcaatttgtt tttccccaag gaagtctttt tccacgcgat attctttttg gccgtttaac 2005441 ataatcttta accttctttc tctttgctgg ttatcgtttt tacattttac aggacaacgt 2005501 catcagctat cggcgtttcc ataattctct tgacgacagg aagatccgaa gactgaccta 2005561 gcgcccacat caattttggc acaattgctt ctgtgttcat atttcttgat cggataatta 2005621 agtcttggtt gactctgcgg ccaacctcgt aaatgctcat gtcttcgcct tcttcaagac 2005681 attgagtcgt aatgacgacg acaatgccgc tttcgatcag ttcattcact tttgacaaaa 2005741 tgtctctgcc ttcaaacggc actcctccgc tgccataact ctcaatgaca attcctttgt 2005801 acatgctttt cagggcatca aacatttcgg gctttaagcc tggatgcagc ttcagcagac 2005861 atacatctgt gcatagtgaa gtgtcaactg tgaaggtgtc gttctcaggt tccgttactt 2005921 gtttgttgta ttcgatcccg tcttcattga taaaagcgat atatgggtaa ttgatgcttt 2005981 caaatgcgtc gtagcttttc gttcttaatt tgatcgcacg cgttccctga atgactctgc 2006041 cgtcaaacac aacataaacg ccgcccacgc cttcacaggc aaatcgaatg gcatctgtaa 2006101 tatttttttt ggcatcggtt ttttggaacg tgatcggaat ctgcgagccg gtgatgacaa 2006161 tcggcttttt ggcatgctgc agcatatacg atagtgcggc agatgtatag gccattgtat 2006221 ctgtaccgtg agtaataaca aacccgtcat aggcatcata attttcctta acggcttctg 2006281 ctatttccac ccagtattca ggctgcatat tggtgctgtc tatattcata agcgactgag 2006341 tttccattgt gtaatcgtta tcaagttttg atacgtaact taataattca tcagccttga 2006401 ctccgggagc cagcccattt tccccttcaa ctgaagcaat cgttccccca gttgtcaaca 2006461 tcaataattt tttcatacca tgcacctctt cactgtatct aaagatgggt tgcgagaagg 2006521 tattcgcttt tcgcatactt ttaatgcaat tatagacacg gaaaataaaa tacgcaagac 2006581 attattattc aattcgcgta cacttcctaa tacctatatg atataatcag ctcaaggtga 2006641 aaaaggagcg gaagttcatg aatctagatc gtttaactga attgagaaaa aagaaaaatt 2006701 ggtcgcttca atatacagct gaccttctcg gtatcgcaaa aagcacatat gccggctacg 2006761 agtcaggcta ccgacggcct tcacttgaag cgcttgccat gctggctgac ctctttgaca 2006821 caacctgcga tgaactttta ggccgcgaga aacaaaagca gactgctcct caggccatag 2006881 aattggccac gtggagcagc ctcgacttta ccatttctgt tgatggccag ccgctgagtg 2006941 aagatgaaat catccagctg attaccttta tacgcacaaa aagaaaagta caggaggaac 2007001 tgagttaatc tttagctcac ggtttaattt taccgtaggt tcctcctcct ccggctttca 2007061 attccagttt tccggatctc gcttttacga taagcgccgc ggttttcggc gggacaacgc 2007121 gagccaaatc ttcttctgca gcctcatgaa gaacagccat ttctgttccg aaggcttttt 2007181 ttagtttgtc cagcgttttc gggcctacac ccggaacaaa ttgcagcggg atctgatgta 2007241 catatcgcgg acgcgggacg cgaacttcaa gctgatcact caattcacgc aatctatcgc 2007301 tgactccctt ggtaaatctg gcttttccgc aattcgcgca cgctgtttcc ccgcttacag 2007361 caggctctcc gcacgcttcg caagccgtct gataatattt ccccaataac gggtccaagc 2007421 cataatttgc gataattttc ctgtcatctt gtccctttaa tgcaagagca aattcagtaa 2007481 aatcagctga ctgcacatat aattcattat attctctgcc gattttcccc aacgaatgcg 2007541 catcagaatt tgttaaaaaa ggatacggat tcaattgcga tacgtgtgat gccatgtctg 2007601 tatcacagct taatccaagc tccaccgcgt ctatcataga tggatcaaaa acctcagtta 2007661 agcttgattt aacccctttt ccatataagc ttttatgcgg cgtaaagata tgggcgggga 2007721 taaacaggcc gcccatatcc tgcacttttt tttgcaggtt taagcccgtt tcataaatcc 2007781 gctgcgagct taaatgaata tttttcagcc gggctgacag ccagtttgaa aactgtttca 2007841 tatcagccag cgtcggcata aatacgagca catggatcgg tccgctgcag gcttcatcat 2007901 aaatctccag ctcgctcccc aataaaagag tcgtgctgcg ataacggatt cctcccccgt 2007961 caagctcgcg atattttcca gatgaaatgc cttcctcaag ctctagaatg acttccggag 2008021 aatgacagtc gataatgccg aggagttcaa ttcctttatg ttcactggct tcaaccaaaa 2008081 ttctgtccag cgttaatgtt ttggcgcctg ttattttgac agcccttcct gtaaaggtcc 2008141 ggccgatatg aatgtgcaaa tccgcgtaaa tctttttcat ttttgtgctt ggagcgcttc 2008201 tttcagctga agatactgaa tcgcgtaggc tgttttagca tcatatactt cacgcgattc 2008261 aaccagcttt agcgcatctt caagcgtcac ctccatcact tcaacaaact cgtcctcatc 2008321 aagctcccgt ttttcttcaa gcacagaaag ctcctcagca agaaaaacgt gaacgatttc 2008381 atctgcaaat ccgggtgatg tataaaacgc agttattttt gtcagttttt ttgctgtata 2008441 accggtttcc tcttcaagtt cccgaagtgc cgtatactcc ggctcctcac ctttttcaag 2008501 cttaccggcc ggaatttcaa cgatcgtccg ctcaagcggc ttacggaatt gtttgaccat 2008561 gatgattttc ccttcatctg tgacggctag taccgctaca gctccagggt gtttcacaat 2008621 ttcacgttta ctggctttgc cgtttggcag ctctacatcc tcgacataaa gatcaatgac 2008681 tttacccgaa aaaatctgtt ctttggcaat tgttttttct tctaatgatt tcatttcttc 2008741 atctcccgtt ctgtctctat atgatgcccc atacatttta tcatactaga gcaaaagggg 2008801 gcttcttcgt gaaagtgcac cgcatgccaa aaggtgttgt cttagtcgga aaagcatggg 2008861 aaattcgagc gaagttaaaa gagtatggac gcacatttca atatgtgaaa gattggatct 2008921 caaagccata aaagttgaaa ctttagctcc tttatattac ggtcaataca aagcctaaaa 2008981 aaggagtgtg cacatgagaa agcgcaaatt gggtacatct gatttagaca ttagcgaagt 2009041 cggactcggc tgtatgtctc ttggaactga aaaaaacaaa gcattgtcca ttctggatga 2009101 agcgatcgag cttggcatca actatttgga cacagcggat ttgtatgacc ggggacgcaa 2009161 tgaagaaatt gtcggtgatg cgatccaaaa cagacgccat gatattattc tggcaacaaa 2009221 agcgggaaac cgttgggatg acggaagcga gggctggtat tgggaccctt caaaagctta 2009281 cataaaagag gcggtaaaaa agagccttac acgtctgaaa acagattata tcgaccttta 2009341 tcagctccac ggcggcacga tagaggacaa cattgatgaa acgattgaag cgtttgagga 2009401 attaaaacaa gaaggtgtca tccgctacta cggcatttct tccatccgcc cgaatgtgat 2009461 taaagaatat gtaaaaaaat caaacatcgt cagcattatg atgcaattca gcctgtttga 2009521 cagacgccct gaggaatggc tcccgctttt agaggaacat caaatcagcg tagtcgccag 2009581 aggtcctgtt gccaaagggc tcttaactga aaaaccgctt gatcaagctt cagaaagtat 2009641 gaaacaaaac gggtacttgt cctattcatt cgaggaactg acaaatgccc gtaaggcaat 2009701 ggaggaagtg gctcccgatc tttccatgac agaaaagtcg ctgcagtatc tgctagcaca 2009761 gccggctgtc gcttcagtga ttacaggcgc cagtaagatt gagcagttac gggaaaatat 2009821 tcaggcagca aatgcacggc gtttaaccga agaggaaatc aaagcgctcc aatctcatac 2009881 gaaacaagac atttacaaag ctcatcgctc atagcagaaa aaccagcacc tgtacgggtg 2009941 ctggtttatt tatattgatg ccaatccatt tggctttcat ttaggagttc ttcaaagctc 2010001 ttattttttt cgatctcttt tttctttcta atctgttctg ctttttctct tttctgcctc 2010061 ttttcatcct cttccttcaa ttggctcttc atctccataa gctttgcttt gatatcggat 2010121 tgaaggccgt cttttagctg gtgtttgtca atggattttt gttttttcat gcagacttcc 2010181 cccatgtttt gttttgaagc cagtttatca cggagcatat aaactgaaca agcagactct 2010241 cttctgatca ctttctcagc gtagcagtgt ttaggtataa tgatcttaaa cacgaattgc 2010301 ctatatattt cgttgaaagg tgctgtgact tttgaagaaa atccttttgg ccattggcgc 2010361 gctcgtaaca gctgtcatcg caatcggaat tgttttttca catatgattc tattcatcaa 2010421 gaaaaaaacg gatgaagaca ttatcaaaag agagacagac aacggacatg atgtgtttga 2010481 atcatttgaa caaatggaga aaaccgcttt tgtgataccc tccgcttacg ggtacgacat 2010541 aaaaggatac catgtcgcac cgcatgacac accaaatacc atcatcatct gccacggggt 2010601 gacgatgaat gtactgaatt ctcttaagta tatgcattta tttctagatc tcggctggaa 2010661 tgtgctcatt tatgaccatc gccggcatgg ccaaagcggc ggaaagacga ccagctacgg 2010721 gttttacgaa aaggatgatc tcaataaggt tgtcagcttg ctcaaaaaca aaacaaatca 2010781 tcgcggattg atcggaattc atggtgagtc gatgggggcc gtgaccgccc tgctttatgc 2010841 tggtgcacac tgcagcgatg gcgctgattt ttatattgcc gattgtccgt tcgcatgttt 2010901 tgatgaacag cttgcctatc ggctgagagc ggaatacagg ctcccgtctt ggcccctgct 2010961 tcctatcgcc gacttctttt tgaagctgag gggaggctat cgcgcacgtg aagtatctcc 2011021 gcttgctgtc attgataaaa ttgaaaagcc ggtcctcttt attcacagta aggatgatga 2011081 ctacattcct gtttcttcaa ccgagcggct ttatgaaaag aaacgcggtc cgaaagcgct 2011141 gtacattgcc gagaacggtg aacacgccat gtcatatacc aaaaatcggc atacgtaccg 2011201 aaaaacagtg caggagtttt tagacaacat gaatgattca acagaataaa aaagcgaaag 2011261 gcctcttcgg ctctttcgct tttttatgtt acagaacgtc ggtaatgcca tccatatttt 2011321 ctctgatcca ttcaatcgca agatctatcg ttgtaaactc ctgcgtctcg aaggtcattt 2011381 catcctgcaa tagccagaca tctttcttga tggactctgc tcctccgatt gaccagtgaa 2011441 gcaaggtata aggatggttt tgattcagga aggataccca cgttttattt tgtgctgtgt 2011501 tcttcattgc cttcagcttt tgttccacgt ttcgcgtctc ctactttact aatatgctca 2011561 ttctggggct gagcatttca gccgggcttt tcagcgccaa tgttttggct ttttcattgt 2011621 aatcgatcgt catttgatcg tcaaaaaaca ctttttgcga cgattggata tacagcggaa 2011681 tgccgttcgt ttccagctgc tcgcactgtc ccgttaattc ttctgccagc cagattgtcg 2011741 ggacaccgct taccgcgcag ccgcatcctt ctgcatcgta acgaagctgg gctttttttc 2011801 ccgggttggc gtcaaacgcc tgctgcagtg cctgttttgc tgcatctgtc acatgtatgt 2011861 tcataaggtg aaacccccgt tttcatcatt ttcgctattg tagcatacaa tactgccatt 2011921 cgcattgttt ctgccttttt tccaccgctt cgcattttct tctgcagtct tgatccactc 2011981 atctttccct tgtatatact gattgatgct gtcagggtgc tgggccgcca gctgtttttt 2012041 gagaacggcg tattctttcg ctatgtttgg atgagctctg agataatctc tgaataacag 2012101 atgcctttca atagcagggt ttccctgttc gtacatatgg acatgatgag tgcgtttatt 2012161 tccgcccttt tggaaataac gcctgcccgc tataccgttc tcaccttttg gtgtatagcc 2012221 gttggccttc atttgttcat caaattggct cacggcttca atgcttctga cttcaattaa 2012281 catatcaatg attggcttcg ctgccatgtt aggtattgat gtgcttccga tgtgatgaat 2012341 agcgataatc tccggcccga acacaagttt cagccgttct ttttcttcat cgaaacattc 2012401 tgcccatttt tcgttgtaga gaatgatctc aacttttctt ttcggataca aatgaaagac 2012461 cgacagcaat agaccctgcg ctgctttgac ggtttctgcc ttttggaatc cggcctgtgt 2012521 atagagtgac acagccgggg tattgttctc ggctgtgact acttcgattt tctcagcgtc 2012581 ttcattatga tcaatgacaa attgcagaag cgctcgtcca attccttttc tgaaaccgtc 2012641 aggatgcaca acaagcctgc aaatggtgag ataatgcatg tttttctcat atgaaatgac 2012701 accgatcagc ttgccgtttt tccgatatcc cgcaaaccgt tcatgggatg cttgaatatc 2012761 ctttaccttc tcttgtaaag cgggaatacc gtcaaaaccg ataatctctg tttcctttat 2012821 gtaggcgggg atctgtacgg ctaaaatctc acgcgctata gtggcttcct tatgctggag 2012881 aaattcaatc attcgtgttc tcctgaaaca gccgctgtct gtcgactttt gcgacgcgga 2012941 ctgcatacga ctcgtaccaa acgcttcttc ctttttcttt tgctgcttga tgttcagtgt 2013001 gatgcctcca atggttaatt gcgtccatac tgtcccaata ggaaactgtg atgccccttc 2013061 catccgcttc acgtacgctt tccacgccta aaaatccagg ctgatccgcc gcaagtgata 2013121 ccatccgctc cgctgtttct ccatatcctg tgtcattttc gcttttgaca gaagaaaaaa 2013181 tgactgcata gtaaggaggc tcaggtgttt ttgataaaaa atccatcata tttccccctc 2013241 atatgttttt gacaaatagt accctgtctt ggcccgggcc atcatagttt gcaaacactg 2013301 agatgccatt taccgttttg gtgccctttt caatatcaaa ccccaatttt gtgtgatatg 2013361 cgattgatac cttattcaca ggtgaagtga cacacttcac ccgggtgcag cccctttgtt 2013421 ttactgtttc gataaataca tcatacaatt gtttcccaat ttgcattttt ctgaaatccg 2013481 gatgcacacc ggaaaaatga atgtacgccg tttcaggatc ggattgcgat tgaaatccga 2013541 ttaaaaatcc cgtcatgctg ttatgttcgg atgtaataaa gcttgtgtcc tgaaaatgct 2013601 caaaaaatag tctcggcaat ttttctttca gctgtctgcc gccccaccat tcattcagta 2013661 cagacgttac catttcataa tctgaagacg tgattgttcg aatatccatt acgatttgat 2013721 ctccctccgt ctggcaaaac gaatgtcagc tctttttctc acaatataaa aattatattt 2013781 tgcctggctg gaattgtaaa tgccttcttt cctgtatcat acgtttccag actgccgagg 2013841 gaacaatgtt tgatcatttt acgcctattt ctcccccaaa caggaggaga gactttacag 2013901 cacaatatca agcacttgat caagtttcag cttataaagc tgatcctcgt ctccttttat 2013961 ccatactgct ttttcaaact cttcataccg gcagattttc ccggtgcagc agacaatctc 2014021 accgtcctga aagcagctga cagtgatatc ctgagcaaac tccatcgcgg cgcaaagcgt 2014081 ttgattcatc tcttccagct tatcggggtc aaggatcggc ttttgcagct tctgtttaag 2014141 tcgctttctc tccagcaggc tttgcttatg ttccggcaga aacatcctgc tcccttccca 2014201 cagcaggttg ccccttttta aatggtcgtt catttataat gcccccctat tttagccgca 2014261 cgttcaaatg cctggcctgc cgctgtcagt gacgccgccc tgatgattgc tgtatcgccg 2014321 aatcgatttt taatgccatc catcacatag cctaggctca ttttctttgc ataatcctga 2014381 aataaattga gctgccatat gtcatcagat gagagctgag acagattgac accgaggcgg 2014441 cggacgggtt tcccgtccca aaatgtaaga aacagccgtc gtacagcctc atatacatcc 2014501 tgcgtagaat tagtcggctc tgccagcttc acttgccggt tgaagcccgt cggccaatca 2014561 aaatcagcac cccggcagct cactgacact gtctgcccca tgaccccggc gtttcggctt 2014621 cgcctgcaca cctcttcact cagctcaagc aatacgacct tgatttcttt gtcaaagtgt 2014681 tcgtagtctc tcgggagagt cattccatga cctatcgcct tttgcccgtc cagagacgaa 2014741 gttgacacag gggaatagtc gattccgttt gccgtcatcc acagcacgtg gccgttaatg 2014801 ccccatttct tttttaaaag atcgagcgga aaagccgcga gcccgccgat cgtgctgatg 2014861 cccattcgat ttaaatgatg cttcatgcgg ctcccgacgc caaacatgct gcccaccggg 2014921 agcggccaca tttcggtttt catattttct ttcgttaagg taaaaatacc gttcttattc 2014981 tttttggcaa aattgtcaca cgcaattttg gccagcgctt tgttagggcc gattccgacc 2015041 cgtgcataaa cgccgatctc ccgcatgatt ctgccctgaa tgcttttcgc gatctccatc 2015101 ggcgtcccaa acagcttctg gctgcctgta atgtccatga actgttcatc gatggaatac 2015161 ggctccacaa ggtctgtata ctcctcgaga atggccgtaa tttgcagtga tacatcaata 2015221 taccgctgca tacgcggccg gagcacaaca gcctcaggac acttttcctg cgcctcccac 2015281 agccgtgaag cattcaccac acccttttgt ttcgccagcg ggcaggcagc caatacgact 2015341 ccgccccttt tttcagggtc acccgaaaca atgacgggcc tatttttcaa atgtggattt 2015401 tccgctttct ctacagatgc ataaaacgat tgcatgtcaa cgagaaaaat cactttttct 2015461 ttcatcatac acacctctaa aaagaactta tgttcgcttt tcattatatg cgaaagtatg 2015521 ttcgttttat actggtaaat gattcttgtc tgacagaaaa tatgatccaa gggtttgaga 2015581 gaagaaaaac atttagtaga ataaaagcga agcataagga taggagagtc atgatggaga 2015641 aatttgtcga aaaaatgctg ggacaggcat tgcggcaata cggcagaaac gttgctatag 2015701 atccgttaag cccgtatgaa aaacaaagcc tgaaagcggc tctacaagag agacggaatg 2015761 aagaaccaga tgaggatttg catgcgcata tagaagatat catttatgac tatgtcacaa 2015821 accaaggcct gttctcttaa acgcatgact gtcagttctt tcagccgctg atgcggcttc 2015881 cctttgaaaa caccgcctga aacaaataaa cagtctcagg cttacagaaa aaaagcagga 2015941 ttttctcacg ctccatagat tcatatggcc tggcgtaaaa ttcccctcaa tgctcgcgca 2016001 aaacggaata agctgtccat gatcacgcgt atacactttt tcgaagagat gtgctctctt 2016061 gttctgtcat gcggtccatg ccggttttca gcgtacatct tgatctcata gccggtttca 2016121 ctgccgatat gatccacgtt ctggcggctt aaactaacac accctcactg accaatcgct 2016181 ttgcttttca tcggacatcc cgtcattttc cttctttcaa gatgtaaact ccgtcagcca 2016241 cacgcatcct caacgcatag tatattgcca tccatacaat caggcatact acatgtcaat 2016301 aacgaaatat tttgaacgat ctattggaga aggaaatttt ttcatatatg atagagaaag 2016361 atcatacata caggagagaa tataattcat gaagaaatgg aaagatatcc acccgatcag 2016421 ctggacaatt ataatcggaa ccattttcgg cagaatggca acatcgatga gcattccttt 2016481 tttagcgatt tatttgacag ccgtccaagg cgcatcagct tcctatgcag ggctggtcat 2016541 cgccgcgagc tcatcagtcg gcatcctcgc aagcttttac ggcggatata tctcagataa 2016601 attcggcaga aaaaacatga tgcttgtatc gattttcgga tggatgctgg tatttgcagg 2016661 ctttgcggca gcatctaatc tctgggtgtt ttttgtagta aacgcattaa acggtctttg 2016721 caaatcactg tttgagcccg cttcaaaggc cttgttgtct gatatgacag aagaaaaaac 2016781 gagactgcta gtttttaatt tacgctatgc ggctattaat atcggcgttg tcttcggacc 2016841 tgtgcttggc ctatatttcg gctcatcgca atcgactacg ccctttttgg tgcctgcagt 2016901 catttacgga ctatacggaa ttgtgcttgc cctccaattt aaaaaacatc catccttatc 2016961 agcaccagcc cagtcccgaa atatgagcgt gcgggaagcg tttatggtca cgcaaaagga 2017021 ttatcttttt accattgctt tggtcggcat tacgctatgc accttcggct actcacaatt 2017081 cagttccaca ttccctcagt atatggcgca gaaccccttg atcggcaatg gaacgaagct 2017141 gtatgggctg atgctgacat taaacgcaat cgttgtgttg gcgacgcaat ttcccattgt 2017201 ccattttgca aaacggtttt cgccgctttg ttctctgatg ctcggtaatg tgatggttag 2017261 catcagcatg gccattttca ccgtatcaca cggtgttcca tcaattgtga tgattgtcat 2017321 cacatttaca atcggcgaag tgcttttatt ctctatgatg gatttgtatg tagaccagat 2017381 tgcaaaacca ggattaaaag gcacttattt cggggcaatc ggtttttcac agctcggaaa 2017441 cgtcatcggc ccttgggtcg gggggatatg tatagacctg tttggcgctg gccggccgat 2017501 ttatattttt tctgtcctga gcggcattac cctgctcggc ctgccatttt tagcgttcgc 2017561 ctatcggcaa atgaaaatgg agaccacaaa acaccgttcc cgtctggaaa agccgcttta 2017621 aataaaaaac ggaagagaat gaatctctcc cgcaaacatg aggtgaagaa catgaatata 2017681 ggtgatgtga tgtttcagct gtttgtattt attatatttg ccgctgtcgt ctttgcggct 2017741 gttacaggct tcaagtatgc gaaaaaccga aaagcgcagc tggatcgcat tgagaaaaag 2017801 ctgaacagcc tgtccgaaga tcacgattaa cagcttgggg caacgagctc taccttaatc 2017861 cggtctggat cctcacaaaa gactgcataa tgcccgtctc ctccggcaaa aggatgcctg 2017921 tctcggtaca acacacgata gccttttgcc gtcaattttt cagtcatctg atcgacttga 2017981 agcttggatt cagcatgaaa tgcgagatgg ttcagaccga ctcggcatct atggtattcc 2018041 ggctctagaa atggctcttt cgcctgcaca atcactaggt aaaaacgatc tttcttccag 2018101 ctgatgcctg agctccattt ttgatactct ttataaccaa gttcttttaa gaaccagccc 2018161 caaaaccgcc tagacgcctc caaatcagag acatacagtt caatatgatg cacatttcat 2018221 accctcctta ccaacacttc ctcgacctta tgcccgtctc ccttacgcaa aatgagatct 2018281 gacctgaatt tagttggcaa aatattttca tataaattcg gccggttgac actctcccaa 2018341 atcgaggctg ccatctcgtc agcctcctga tcggacaagt ctttaaattt atgaaaatat 2018401 gaatcaggat tttgaaaagc tgtttcccga agcaggcgaa aacgctctaa ataccaagtg 2018461 aaaatccggc tttcctccgc atccacataa atcgaaaaat caaagaaatc ggaaacaaaa 2018521 atacgcgggt tttcccggtc atcctccaag gtgggcgact gaagaacatt aatgccttca 2018581 ataatcacaa tatccgcctg ttctacaacc tcgaacacac cttcctcgcg gtcataggtt 2018641 agatgggaat acaccggggc ctttacgctg tcctttcctg attttaagtc attcaaaaat 2018701 tcgagcagcg cctttacatc atagctttca ggaaatcctt ttcttgacat catatttttc 2018761 tttttcagct cggcagtagg aaataaaaaa ccatctgtcg tgataaggct cacttttgga 2018821 cggtcaggca aacgcgaaag cagcttctgc aagatccgcg ccgtcgtgct ttttccgact 2018881 gcgacactgc cggcaatgcc gataataaac ggaattttgg ctgaatgtgg gtgcttcaaa 2018941 aaaacattga catgcttatt gcgttcagcc gcagacttga catgtaaatg aagcaagcga 2019001 acaagcggaa tatagatcgt ctccacttct tcaacagata gataatcatt caatccttcc 2019061 acagcttttg cctcttcttc agatacagca atcgacaaat gccccccaaa accagaccaa 2019121 gactcccgat tgtgctgtgt atataaagta tgtaggttaa gttctttatt tttcactgtt 2019181 tacacctgac tctctgtagg ttaaaaccct tacaaagatt gtaacggaaa accttttcac 2019241 tgtctgctta tttttcattt cgttttttta gcaaatcagc accgattcgg ttatacgcag 2019301 ccatttcatc ttttggaacc atgcttcctc ccgttcccca gacgacatgt acggcatgtt 2019361 ccatcttata tttctgagca tagcgccttc cctcttctgt cgaaaaaagc tgaaccggcc 2019421 cgaacatgcc agcaagagca gagggctcta aatatttatc ttcagataca gccagcatat 2019481 gaagcaaagt ataaagcgta ttgtcctcta ccgtataaca gccgctcaga agcggttcaa 2019541 tcagcttgcc gacaaatcct gacggcctcc ctacggcaag tccgtcagca gccgtctgat 2019601 tatccaggcc gatatcctgg acggagatct tctcgtgaag tcctgaataa agccctaaca 2019661 gcatacaagg tgaatgagtt ggttctgcga aaaacacatg aacatcatct ccgtataaaa 2019721 gcttcagccc aaatgctaca ccgcccggtc ctccgccgac tccgcacggc agatacacaa 2019781 acaagggcgt ctcaagactt ggctttatat tcatacagtc aagctgtgtt tttaatcggc 2019841 ttgcagcaac agcatatcct aagaacagct gacgagaatg ttcatcatca ataaaataac 2019901 agaatggatc ttgttccgcc tgccgtctcc cttcgttcac cgcttcactg taatctgttt 2019961 cgtactccat aacagtgact cccttttggc ggaggagatc ctttttccac tgcttagcat 2020021 cggcggacat atgcactgtc acgcgaaacc cgagtgccgc gccgatgatg ccgatgctta 2020081 aacctagatt tcctgtcgaa ccgacagcaa tcgaatagcg ggagaaaaac ccggtaaacc 2020141 gctcttcctg taagatgcgg taatcatcgg tttcctgaag cattccttct tgaagcgcga 2020201 gattttcagc atactttaac acttcataaa tcccgcccct cgctttaatc gatcctgaaa 2020261 tcggaagctc atggtcgcac tttaaaagcc atcttccggg aaatggctgc tgatatgccg 2020321 cttccagctt tcccttcata tgctgcacct caaaaagcgg agactcgatg attcctttag 2020381 cgcctttcgt ctcaggaaac acctcggcaa tgtaaggtgc aaaccgctgc attctttttt 2020441 ccgcttccgc tatctcggtt gcccactcat ctgcacgggg taatggcccc tctttcttgc 2020501 ctgaatttgc ccagaataca ggctctgcat caatcagttt ctgaataaac ggatctttaa 2020561 gcagagcatg aaggacttct gaatgaactg acattcaaca atctctccct tccactatca 2020621 aaaactgccc cgtgagaaac aagccactcc accacaggca gttctatcat tattttttca 2020681 tgagcgcgcg tcctgccagc ttttctacaa gagctggaaa cagctgatac agcttagtgc 2020741 cggcattcat taaacgcgga agattgatct cccgcttttt cgtaaaaatt gcagctgtaa 2020801 tttgagctgc cacgtcatca ggatcaagca tccagcggcc gacatttttg gcgtagtccc 2020861 cgcctttatc agcaatggaa aaaaagtccg tctgaatcgg gcccgggttg actgttgtca 2020921 cataaatgcc ggttcccgaa agctccatcc gcaaagcgtt tgagtaacct aacacggcat 2020981 gtttggtcgc ggaatacagg ctagacttcg gtgtggcgat tttccccgct tgagaggcga 2021041 tattgatgat atgtcccttt ttttgctcaa gcatttgcgg aagcaccgct tttgtacagg 2021101 cgatcaggcc gaagacattc acatcaaaca tcgctttcat gtcatccaat gtagagtcta 2021161 aaaccgtttc aaatataccg aagcctgcat tgttaatcag tacatcaatc gagccgatct 2021221 gatcgcggac ccgggcgata tcctctaggc ggccgacatc cagaggaaaa atctcacact 2021281 gtccgctcca ttcctcggtt attttccttt tgatttctat caaacgatcc tcgcgtctag 2021341 ccgacagcag gacatgggct ccttcagccg cgcataagta tgcgattctt tctccaagcc 2021401 ctcctgaagc gccggttatc caaatccttt ttcccgctat atgtttcacc catttcacct 2021461 cttcattgtt ttaaagtata cggtatttcc ttcccaatat gacgtgatgg cttcttcagc 2021521 ctccaacaca tcaaggtgac ctgccgtttc tgacatcgtt aaaaacaatt ccttttcata 2021581 tacagcagga aaaagctgct gacagacctg aaaagcggtc atcggctttt catccagcat 2021641 gcgacgcaca tcctccgtcc tgttcctctg cttgtcaaaa cgcttctcaa tcagcgcttg 2021701 tacactggtg ataggctcgc cgtgaccagg aaatacgatt gttggatcaa gttgagacag 2021761 ccttcgcaat gaccgctgat aatccactaa aggctttgac ctgacgtctc ccgctttcgg 2021821 cgcttccaaa atcggattag acgagctgtt tgccagcagt agatcgccgc caagcatcct 2021881 tccgcttttt tcatggaaca gaacaatatg cgattcagca tgtccaggca tctccaacac 2021941 agaccagccc tcaagcccat ctatgcccat accttctctg attgattttg tcagagatct 2022001 cgtacaggaa aatgcgtacg ctgatcgaat cagcttttcc gccttccccg tatcaaatgg 2022061 aacgcctaat tcaggcagca gcttttgaaa aaaacgtttt tgccaatcca taaaggcttg 2022121 attttggctg atataaggtt cgttgaatgt atgcccaatc acttcgattt catctgaaaa 2022181 gacatcaagc aagcctgcat gatcagcatg atggtgagtc agtacaacct gctcgatatc 2022241 tgacaatttc acatttacag cggcaagctg ctcttgtaag gctctggcag cctcttttgt 2022301 attcggcccg gcatcgataa gtgtcagcgc atcacctttt acgaggtaaa cgataacatc 2022361 gccgacagca aacggtgtcg ggacgcggat cgcaattaca tcttcagttg tcatcctttc 2022421 gctccttgtc ttcattcatt attcatattt tagctttttc tcggtcttgt gtcattattg 2022481 cagaatgaga acaaaccttt ttgaaaaagc tattgacatt agcttgtccg ccattgcata 2022541 atgaacaaca aactaaaacg agaaccattg gaacgctatg acgaggaata gtatacaagg 2022601 caatggccta agagagcgat acccccggct gaaaggtgtt gcggcccgct tgtttgtaga 2022661 acctgccctc aagtcgcggt taggaaaacc taaacgtttc ccgcgttacg gggatttgag 2022721 ctgagcacaa tttgtgctaa tgagggtggt accgcgaacc ttttcgtcct ttacgtgatg 2022781 aaaaggtttt ttgttgttct aatagaagga ggatatcaat gaaaaagata ggatttgtcg 2022841 gcgccgggtc aatggcagaa gcaatgatca acggcatttt gcaaagcggc atcacaaaac 2022901 cagaacatat ctatattaca aatcgctcaa atgacgagcg tctgattgaa ttaaaggaaa 2022961 cgtacagcgt gcgtccatgc agagataaaa atgagttttt cactcacacc gatatcatta 2023021 tcctcgcttt caaaccgaaa gacgcggcgg aaagcatcga cagcatccgg ccgtatatca 2023081 aggaccagct tgtcatttca gtacttgcag gccttaccat cgaaaccatt cagcattatt 2023141 ttggcagaaa gctcgcggtc attcgcgtca tgcctaatac atcagcggca atcagaaaat 2023201 cagcaaccgg attttccgta agcacggaag caagcaagaa tgatattatt gccgcaaaag 2023261 ctctattgga aacaatcggt gatgcaacac tggttgagga gcggcatctt gacgctgtca 2023321 ctgcaatcgc aggcagcggc ccggcctatg tgtatcgtta tattgaggcg atggaaaaag 2023381 cagcacaaaa agtaggatta gataaagaaa cggcaaaagc actcattttg cagacaatgg 2023441 caggggcaac agatatgctc ctccaaagcg gcaaacagcc ggaaaagctg cgtaaagaaa 2023501 tcaccagtcc tgggggcact acagaggcag gtcttcgcgc tttacaggac tcccgctttg 2023561 aagaagcaat tattcactgt attgaagaaa cagctaaacg gagcgcagaa atcaaagaac 2023621 agtttgccgg tgccgcctta gagagacatt cttagatgta aggacaaaaa cagaaggcac 2023681 agtgccttct gttttttatt tttcccgcag cagctggccg gcagattctg attgctttaa 2023741 tagcgcggag atcgtaaatg aaagcaaatc gggaagcact tcaaaggaat aaggcatata 2023801 caatctttcc gtccatttat gcgggtcttt accagccgga ccgacattta aaactgggac 2023861 atataaagcc tgatttttac cgcttggcaa tgaataccct ctgttaaaga gcggcatatt 2023921 gcttgtgtat gcatcaacct cctgtttttc cagctgaaga taactcaagt ccgaaagtcc 2023981 ggggaagtac tgaacctccc gtaatgcaat gccgtatcgc tcagccgcat aatgctttat 2024041 ctgatctgct gtatttctga tcaattgatc atcctttgaa gaaacagctg gataaagcgg 2024101 cggactataa aacagaacga tgagcggcgc atcctcctta caaagcgaag caagctcaga 2024161 aacaattttc gtcgaaaaat ccctgtctcc aagctccccc ctgttagcaa aggcataatt 2024221 tagagcccgc tctgtttccg agatccccgc acgctttttt gcacgcgaga ccagctcatc 2024281 aaatgtcaaa acagtgacgt cccgctcaat cggctgaaat ggctcaaatt gttgaaaatc 2024341 ctgtgttttc ttccgaacgt tcgacatgat ttcctccgcc gcctgttctg ctgttttaag 2024401 cagcatctga tgcagctcac tagctgagcg tttcattgac agcacattaa ataatgtgac 2024461 ggctgtatgc ggtgtctgga ctgaatatgc ctctttcaag tccttttgca ttaagtttac 2024521 cggcggcgga gtgacctcgc catcaacctt ttcgcaataa tcagcattca gttcaagcaa 2024581 acggttaatc tcagatacca ttaaatttgc gtttagacct gaaaacggct ctccaacatg 2024641 tgtctcaatc cccttgcaga aaaaacccgc aagcaccttg ccaatgcttc ctgtataaaa 2024701 atattgctgc tgatcgccgg gaaatttttc aaacatcggt tcggcattca ggcaagcggt 2024761 taatgtgata tcatgctttt tctccatctc cttcaatgca ggaaccgctt caatcatgcc 2024821 tcttgaattc acttcctcgt ccggaaccgt tatcaacagc agattgccct caaaatgccc 2024881 gttcattgcc ctctccagca tcgacagttg aatacaaagc cccgctttca tatccatcgt 2024941 ccctcttccg aacagccagt ctccgctttc ggcatctctt ctcacacgtt ccgggagcag 2025001 ctcttttttc tctaaaaagg agctcaaaag ctcagcaggc ttgcaagcca tatgtttaaa 2025061 ttcgccgtaa tcttctatgt caacgacatc aaaatgactc agcagaagca ctgtcttttt 2025121 gacattcttc tttttgacta gagccgtaag aaaagatctg ccatcgtcca tcggatgaag 2025181 tgttacatca tcagggtgct tttgaaaata gggcttgtcc ttcaaaataa aataaagata 2025241 ctctgcaagc gctacctcgc cctttgaacc ggtgatgctt tcgtattgca caagagaagt 2025301 taaaagtgcc agcaattcgt ccttcgtctg ccaattcatt gattccgccc ctcctatgaa 2025361 taaaaatgct tctatactga aaaataaact gatttctcgt ctattataca gaaatgtttg 2025421 acaaaagcgg ttcatttgag cagtttatat gacgggaaag aaatgacttg atataatcaa 2025481 tctctaaaaa ccttacggga ggcgaaagaa atggccagaa aattatttac acctattaca 2025541 attaaagata tgacgttaaa aaaccgcatt gtcatgtcgc caatgtgcat gtattcttct 2025601 catgaaaagg acggaaaatt aacaccgttc cacatggcac attacatatc gcgcgcaatc 2025661 ggccaggtcg gactgattat tgtagaggcg tcagcggtta accctcaagg acgaatcact 2025721 gaccaagact taggcatttg gagcgacgag catattgaag gctttgcaaa actgactgag 2025781 caggtcaaag aacaaggttc aaaaatcggc attcagcttg cccatgccgg acgtaaagct 2025841 gagcttgaag gagatatctt cgctccatcg gcgattgcgt ttgacgaaca atcagcaaca 2025901 cctgtagaaa tgtcagcaga aaaagtaaaa gaaacggtcc aggagttcaa gcaagcggct 2025961 gcccgcgcaa aagaagccgg ctttgatgtg attgaaattc atgcggcgca cggatattta 2026021 attcatgaat ttttgtctcc gctttccaac catcgaacag atgaatatgg cggctcacct 2026081 gaaaaccgct atcgtttctt gagagagatc attgatgaag tcaaacaagt atgggacggt 2026141 cctttatttg tccgtgtatc tgcttctgac tacactgata aaggcttaga cattgccgat 2026201 cacatcggtt ttgcaaaatg gatgaaggag cagggtgttg acttaattga ctgcagctca 2026261 ggcgcccttg ttcacgcaga cattaacgta ttccctggct atcaggtcag cttcgctgag 2026321 aaaatccgtg aacaggcgga catggctact ggtgccgtcg gcatgattac agacggttca 2026381 atggctgaag aaattctgca aaacggacgt gccgacctca tctttatcgg cagagagctt 2026441 ttgcgggatc cattttttgc aagaactgct gcgaaacagc tcaatacaga gattccggcc 2026501 cctgttcaat acgaaagagg ctggtaatgc ccataagaga tatcctgtag aggatatctc 2026561 tttttttatt tttagagaaa cgatcggcta aggttctccg tctccctagt agaaccaatt 2026621 agaggagatg actccaatga aatcagcttg gatggaaaag acatatacaa ttgacggatg 2026681 tgcgtttcat acacagcacc ggaaaggatc aagcggtgta acgattgtct ttgaggccgg 2026741 ctatggtact tcttctgaga cgtggaaacc attaatggcg gacattgatg atgaatttgg 2026801 cattttcaca tatgatcggg caggcatagg aaaaagcggg caaagcagag ctaaacgaac 2026861 agctgatcaa caagtgaaag aattggagag tttgcttaaa gcagctgatg taaaacctcc 2026921 ttatttggct gtttcacact catacggagc tgtcatcacc ggtttatggg cctgcaaaaa 2026981 caagcatgat attatcggca tggtccttct tgacccagct ttaggcgatt gcgccagctt 2027041 tacctttata cccgaagaaa tgcacaaatc acatacgaga aagatgatgc ttgagggcac 2027101 acatgcagag ttttcaaaaa gtctgcagga gctcaaaaag cggcaagtcc acttaggaaa 2027161 catgcctctt cttgtgttgt catcaggaga acggactgag aaattcgctg ctgaacagga 2027221 gtggcaaaac ttgcacagca gcatattgtc tctatctaac caaagcggct ggattcaagc 2027281 taaaaacagc tcccacaaca tccatcatga tgaacctcat atcgttcact tggctattta 2027341 tgacgtatgg tgcgcagcgt gccagcaggc cgctcctctt taccaggcag tcaattaacg 2027401 taaaaaaaga ccgggccgta agggattccc ggtcttttat attattttgt ttcacggtga 2027461 agggtatatt tctttaaacg cggtgaatat tttttcagct ccaaacggtc tggattggtg 2027521 cgtttatttt ttgttgtgat gtaatttcgg tctcccgttt cagtgcaaag ctaaagtaac 2027581 atttactctc ataattaaca tctccttata aaacgtaatg attacgtttt attatacaac 2027641 gtcatcacaa attgtcaaat aagagctccg ccttcagcct cgcgggacgt ttacctctaa 2027701 gaaatcatat gccgccacgc tattggggaa aacgtcaacc gcttcttttt gaagctccaa 2027761 agaagcatct ccctgatatc ttgcgctgat atgggttaaa atgagctgct tcgctcttgc 2027821 ttctttcgct gttacagccg cttgttccgt tgtactgtga taataatcat aagcaagttt 2027881 acggtcttcc ttagcaaagg ttgcttcatg aacaagcaca tcacaatccc tcgcaagctc 2027941 ttttagtttg tcacttactc tcgtatcacc ggagaacaca acagatcttc cctttttagg 2028001 aggctccaga aaatcattcc cattgatgat tcgtccgtct tcaagcgtta ccgtttcgcc 2028061 ttttttgatt ttctgatata caggtccggg cgggatgttc atttctttta atacgtcagc 2028121 cttcaaggaa cccggtacgt ctttttcctg cacacggtac ccgaaggctt ccactccatg 2028181 aataacagat accgctgtga caataaactg atcgtcctca aacacgattc cttcttcaat 2028241 ttcctggatc gcaagcggat atgtcaaatg ggttttcgtg acggcaaggc ttgtttcaat 2028301 aaacgccttg atccctttag gtccgtacac tgtcagctcg tcctctccgc cttgaaagga 2028361 acggctcccc agaagccccg gaagtccgta tacatgatcg ccgtgcatgt gtgtaataaa 2028421 gattttctct attttacgag gtttaatcgt tgtatgtaaa atttgatgct gtgtggcttc 2028481 cccgcagtca aaaagccata ccgaacgcct ttcttcaagc aattttaatg ccaccgacgt 2028541 tacatttctc gccttggcgg ggatgccggc tcccgtccct aaaaaaagta attccacgtt 2028601 tccttcctcc tactagaacc agatacctac aagaatacag gatcaagcgg aaaatgtgaa 2028661 tcttgcctct gaaaagaaca atcctttcgt gctagaaaca ttttttcagc attctgctta 2028721 aaaaagggct taaatgtttg ctttcgttga attttagatt taaaatgaag gaaatatacg 2028781 gggtgtacta aaataaagct tcgaataaag tgaggtactt ttagtgaaaa caaaccaaca 2028841 accaaaagca gtaattgtca tattcggtgc aactggagat ttagcaaaac gaaaattgta 2028901 tccgtctatt caccgtttat atcaaaacgg acaaatcgga gaagagtttg cagtggtagg 2028961 agttggaaga agaccttggt ctaatgagga tcttcgccaa actgttaaaa catccatttc 2029021 ctcatctgca gataagcata tagatgattt cacgtctcat ttttactatc acccgtttga 2029081 cgtgacaaac cctggttctt atcaagagct aaacgtattg cttaaccagc tggaagatac 2029141 atatcaaatt cctaacaaca gaatgttcta cttggcaatg gctcctgaat tcttcggaac 2029201 gattgcaaaa acattaaaat cagagggtgt aacagctaca accggctggt cccgccttgt 2029261 catcgaaaaa ccgttcggcc atgatctgcc aagcgcacag gcattgaata aagaaatccg 2029321 cgaagcattt acggaagatc aaatttacag aatcgaccat tatctaggca aacaaatggt 2029381 tcagaacatt gaagtgattc gatttgccaa tgcgattttc gaaccgcttt ggacaaaccg 2029441 ctacatttca aacattcaaa tcacatctag cgaatcacta ggcgttgaag accgcgcaag 2029501 atattacgaa aaatcaggcg cccttcgcga catggtgcaa aaccatatta tgcagatggt 2029561 tgcccttctt gcaatggagc cgcctatcaa attgaacaca gaagaaatcc gcagcgagaa 2029621 agtgaaggtg ctgagagcac tgcgtcctat tgcaaaagac gaagtggatg aatactttgt 2029681 gcgcggacaa tatcatgctg gtgaaattga cggtgtaccg gttcctgctt atacagatga 2029741 agataatgtc gctcctgact ccaatacaga aacctttgtt gccggcaagc tcttgatcga 2029801 caacttcaga tgggctggtg ttccattcta catcagaacc ggaaaacgaa tgaaagaaaa 2029861 gtccacaaaa attgtcgttc aatttaagga cattccgatg aacctgtact acggtaatga 2029921 aaacaacatg aatccgaact tgcttgtcat tcatattcag cctgacgaag gcattacgct 2029981 ttacttaaat gctaaaaagc ttggcggagc agcacacgca cagccaatca aactcgatta 2030041 ttgcagcaat tgcaatgacg agttgaacac ccctgaagca tatgaaaaac taattcacga 2030101 ctgtcttctt ggcgatgcaa caaactttgc acactgggat gaagttgccc tttcttggag 2030161 ctttgtcgac tctatttctg aaacatgggc agcaaacaaa accttatctc ctaactacga 2030221 atcaggctca atgggaccga aagaatctga tgatcttttg gtgaaagacg gcttacactg 2030281 gtggaacata taataagaag aaaaaagccg aaaatgttta caagcatttt cggctttttt 2030341 acgctgaaca aaggtataac aatctcctta ataacaaaac ccccaaagct taagagcttc 2030401 gggggtttct attgattact tcatccattc agtatggaag atgccttctt tgtcagtacg 2030461 ctcataagta tgagcgccaa agtagtcgcg ctgtgcttgg attaagtttg caggcagtac 2030521 ggctgtgcgg tagctgtcat agtaggctaa tgcgcttgag aatgatggca ccggcacacc 2030581 ttgggcaact gcaagtgaaa tcacttggcg aagcgctcct tgatagcttt ctacaatatt 2030641 cttgaaatag ctgtcaagaa gcaggttgtc aagctcaggc tcgcgatcgt aagcttcttt 2030701 gatcttctga aggaatgccg cgcgaatgat gcaaccaccg cggaagatca tagcgatttc 2030761 accatatttc agatcccagt tgtattcttc agaagcagct ttcatttggg caaatccttg 2030821 cgcgtatgaa cagattttac tcatgaacaa cgcttttctg accgcttcaa tcagctcttc 2030881 tttattttct gtaacaggct tcacttctgg tcctgaaaga agtccgctcg cttttacacg 2030941 ctcttccttc atagctgaga taaagcgtgc gaatacagat tcagtaataa tcggaagcgg 2031001 aacgcctaag tcaagtgcgc tttggcttgt ccattttcct gttccttttt ggcctgcttt 2031061 atcaagaatc acatcaacaa gcggtttgcc tgtttcttcg tctttttttg tgaagatgtc 2031121 agccgtaatc tcaatcaggt agctatcaag ctcaccttta ttccattcag cgaaaacttc 2031181 atgaagctca tcagcagaaa ggcccagcac ctgtttcaga atgaaatatg attcagagat 2031241 cagctgcata tctccgtatt caattccgtt gtgcaccatt tttacgtaat ggccggcgcc 2031301 gtccggaccg atatatgtcg tacaaggttc tccgtcaact tttgcagaaa tggcttcaag 2031361 aatcggtttt acaagctcat gtgcttcttt ttgtccgcca ggcatgatag aaggtccttt 2031421 aagcgctcct tcttctccgc cggaaacgcc tgttccgata aaatgaatgc cgctttcagc 2031481 gagttctttg ttacggcgct gtgtatcttt atagtatgta ttaccgccgt caattaaaat 2031541 atcatccttc tctagatgag gaagaagaga ttgaattgtc gcatctgttg cagttcccgc 2031601 tttaaccatt aataagattt tgcgcggtgt ttccaaggat tggacaaatt cttcaatgct 2031661 gtaagtgcca acaacatttt ttccttttgc ctcctgtaaa aactcctcag ttttactgct 2031721 tgatctgttg taaacagaaa cagaaaatcc ccggctttcg atatttaaag ccagattttt 2031781 acccatgacc gcaagtccga taacgccgat ttgttgtttt gacatattct aacgtccctt 2031841 ctgcaaacgt ttaatcattt taaaatttaa attaaaataa aatgatattt ataataaaga 2031901 aattaccata cattcaccct ttttttcaag cgattcagct tttcttttca tcttgaaaaa 2031961 aatctttatt aaagcttgtt ccctttgttt tgctctcctc tttttttaac gttgcccctt 2032021 ttctgatcag tttggtaccg tactttttat tcagcttttc catcatctgc tgaatgggct 2032081 catccttcgc atcttcatta aagctgaaca aatcgagctg tttataggcc tgctcttttt 2032141 ctactaaatc cgttccggta atgccaagca gcctgacagg atttttattc caatgtttaa 2032201 aaaagaggtg ctccgcttct ttcaaaatgt catttttttg atcaatcggg tttctcagcg 2032261 tagtgcttct tgtgatggtt ctccaatccg catatctaat cataataaaa agcttcgaag 2032321 ccatgacttc cttgcgctgt aaacggtcac tcacagaagc ggcaagcttt ctaaaaacgc 2032381 ctaacagctc ttcttcatca ctggaatcat gggaaagtgt cgatgagttg ccgacgcttt 2032441 taaattcgta aatgcgctcc gggtcaaccg gcgcatggtg aatgccattt gctttatttt 2032501 taaggcgcgg accgttgatg ccaagcaggc gcttcagcga gtgttcatca gctgcagcta 2032561 gctctccgat tgtatggatg ccgagtccct tcagtttttc cgctgtcttt ttgccgactc 2032621 cgtgcatctc tccaacagga agcggccaca ggatatcggg cacttgcctc tttcttaaga 2032681 tcgtaattcc aagcggtttt ttcatatcag acgccatctt agcgagaaat ttattcggtg 2032741 caatccctat gcttgacggg agcagcagct ctttttgcag cctgctttgg atttcttttg 2032801 ccgtctctag agcgcggctg ctgtatggtg tatcggtcat gtccatatag ccttcgtcga 2032861 tggagacagg ctccactagg tcagtatatt cacgaagaat ggtaaacatc gctcgtgaag 2032921 agtttctata gcggtcaaag ttcggcggaa gaacgatgag ctcaggacaa tggcgcttcg 2032981 cttgccaaac cggcatcgtt gttttgacgc cgcgcgctct tgcttcgtag ctgcatgtta 2033041 ccacaatgcc ctttcgctcc tttacgtttc cggcaactgc gaccggcttt ccccggagag 2033101 ccggatcata tgccatttca accgacgcat aaaagctatt catatcaata tggaaaataa 2033161 ttcggctctt tcccggcata aacaaatctc cttttcggtc attagacaac agcttgtaca 2033221 tatagtaaaa tgaagctatt gaatggatgt gatgacaatg tttgtggaat cgataaatga 2033281 cgttttattc ttagtcgatt ttttcacaat tattcttcct gctctaacgg caatcgggat 2033341 tgcattcctc ttacgggagt gccgtgcggg cgagcaatgg aaatcaaaac gaacagatga 2033401 acatcagacg gtctttcaca ttaaccgaac agactttctt attattatat atcatcgcat 2033461 tacaacttgg atacgtaaag tcttccgcat gaattcgcct gtgaacgatg aggaagacgc 2033521 cggttctctt cttttataaa ccgcatttat aaaaaggagg agaacaaaat tgttaaaaac 2033581 atatcaaaaa cttttggcta tgggtatctt tttgatcgta ttatgctcgg gcaatgctgc 2033641 atttgcagcg actaatcagg tgggaggcct cagcaacgta ggttttttcc acgattattt 2033701 aatcgaaccg ttttccgctc tgcttaaggg tgttgccggg ctgtttcacg gagaatacgg 2033761 actctctatt atcctcgtaa ccattattgt gcgtatagtt gtattgcctt tgtttgtcaa 2033821 tcagttcaaa aaacagcgca tcttccaaga gaaaatggcc gttattaaac ctcaggttga 2033881 cagtatccag gttaagttga aaaagacgaa ggacccggaa aagcaaaaag agctgcaaat 2033941 ggaaatgatg aagctgtatc aggagcataa tatcaacccg cttgcgatgg gctgtcttcc 2034001 aatgctgatt cagtctccga ttatgattgg gctttattac gcgattcgct caacacctga 2034061 aattgcgtca cactcgtttc tatggttcag tttagggcaa tctgatattc tcatgtccct 2034121 tagtgcaggg attatgtatt ttgtccaagc ctatatcgct caaaaactga gcgcgaaata 2034181 ttccgctgtc ccgcaaaacc ctgcagcgca gcaatccgca aaattgatgg tgttcatctt 2034241 ccctgtgatg atgacgattt tctcgcttaa tgtgccggca gcccttccgc tgtactggtt 2034301 tacaagcgga ctgtttttga cagtgcaaaa catcgtcctt cagatgacgc atcataaaag 2034361 taaaaaaaca gccgctctta ctgagtcggt gaaataaaaa agcaaccccg tgcaaaaagc 2034421 cggggttgtt ttttgttact tgcaaagtac cgcgccaaac agtcttgttt atcatggctg 2034481 aagcagaaat ggccatccta aaaaatagcc gtatcgttta aaaagaagga aatcgggaat 2034541 acctttactc acctccaacc gaaaggagcc tatacgttga cggaacgctt tcagcaaaaa 2034601 aatatttctg tacctgatgg aatctggatc atgagacaaa cctggaatga tgtcttattt 2034661 gctcactggc ctgttgatgt ttctatcctt cgcgctttgg taccgtccgt tttagaatta 2034721 gatacatata acgggcaagc ttggatcagc atgcttccct ttatgctcac gaacctgagg 2034781 gcgcgttatc tccctgtcat tcccggtgcg cgtgcatttc ctgagcttaa cctccgcacc 2034841 tatgtcacgt ataaaggcaa gcccggcatt tattttttta gcttagatgc cgatcatcgt 2034901 ctggcggtcc ttggcgctcg cacattcttt catctgcctt atttttacgc ggatatgaag 2034961 tccgaaaaaa acggtgatgc cattgactat gtcagcaagc ggaaaaatga caaagaagca 2035021 gcattccacg ccgcataccg gccaatttca gcgcctttta cagcagaaaa ggattcgctc 2035081 gattactggc tgacagaacg atacaggctc tacaccactt atcgcaataa gctctattac 2035141 gaagacatcc atcatcatcc gtggctgctg caaaacgccg aagcagaaat ttcagtcaat 2035201 acggtgactg atgctcacgg tattacattg ccggagtcag accccttgct tcattatgct 2035261 aaaaaacagg atgtgttatt ttggccgctt aggaaatgga gctaaaaaaa cccgatgcgg 2035321 gaaatcgcac tcgggttttc tttttttatt ttgccgcctc ttcaataatg gcaacaacca 2035381 tttctgccgt tttaacgagc tcttcgatcg gcattttttc attttttgta tggatttgct 2035441 cataaccgac agcaagattg accgtcggga tgccatgacc agcgattacg ttcgcgtcgc 2035501 ttccgccgcc gctcgtttgc agctcgcttg gacgtccgat tttagcagcc gcttttttcg 2035561 cgatttcaac aacttggtcg ccgtcttgat atttaaagcc cggatacata acctcaattt 2035621 cgacttctgc gcgtccgccc atatcagcag ctgcctcttc aaaagcagct ttcatttttt 2035681 gaacctgagc ttccattttc tcaggaacta aagagcgcgc ttcagcaaga atatgaactt 2035741 cgtcgcacac aatgtttgtt tgtgtgccgc cttcaaaccg gccgatatta gctgttgttt 2035801 cttcatcgat acggcccaat ggcatttttg agatggcttt gctagcgatt gtaatcgctg 2035861 aaatgccttt ttcaggttca accccggcgt gagcggtttt cccgaaaatt gccgctctta 2035921 ccttcgcctg tgtcggcgcg gccacaatga tatttccgac ttttccgtct gaatcaagag 2035981 catagccgta ggatgcagtg atcatagaac ggtcaagcgc cttcgctccg atcagacccg 2036041 attcttcccc tactgtgatg atgaattcaa tcgtgccgtg ttcaatattt tcttctttca 2036101 gcaccttaat cgcctcaaac attgcagcca atcccgcttt atcatcagca cctaaaatcg 2036161 tcgtgccgtc agttttgacg taaccgttct ctacaactgg ttttacgccg tttccgggta 2036221 caactgtgtc catatgagat gtaaaataga tcgtatctgt ttgttttgtc ccttttagcg 2036281 tgcaaatcag gttaccggct ccgtggcccg tgatatccat tgtatcgtct tctttaacgt 2036341 ccacacctaa atcagaaaat tttcgtttca gcactttgca gatttcagct tcgtgctttg 2036401 tttctgagtc aatttggaca agctctaaaa attcttccag caggcgtttt tcattcacca 2036461 tttgtaagtc cctccatatt aaagcggtat gttaccgtgc ttttttttcg gtctctcttc 2036521 tgtcttatgt gtaagcatat gaaaagcttg aatcagtctt ccccttgatt cttccggcaa 2036581 aatgatgtca tcgaccattc cacaagcggc cgctttgtat gggccggcgt tttgcttttt 2036641 gtattcagca gttttttcgc gtttcgtctt ttgcgggtca gctgaagctt tgatttcctt 2036701 ttcatacaaa atcgatgccg caccttctgg acccatcact gcgatttcag cattcggcca 2036761 tgcaaacaca aggtccgctc cgatcgcttt gctgttcatg gccacatagg cgccgccgta 2036821 cgcttttcta atgatgagtg tgacttttgg gacagtcgct tcagcataag caaacaataa 2036881 ttttgctcca tgcctgatga ttccgttgtg ctcttgctga atacccggca gaaaccccgg 2036941 gacatcttcg acagtcaaca gcgggatatc aaatgcgtca caaaaacgga tgaaccttgc 2037001 tgctttatca gcagcgtcaa tcgtcaggct tcccgccaga tgcttcggct ggctcgccac 2037061 gatgccgatt gctttttcac ccagccttgc aaacccaatg acaatgttct tcgcaaaaaa 2037121 tggctgaatc tcaaaaaaag actgcgggtc agccagctcc ctaatcacct tccgaacatc 2037181 ataaggcttt gtcgtatcag cagggacaag acggtttaat aacggtctgg acgcctcttt 2037241 ctctggcttc ggctctgttg tccggccatt cagcggcaaa taagacagta gttttctcac 2037301 ccctgtcaga acctccttct ccgtatgccc ggaaaagtgg gcgtttccgc tgacggcatt 2037361 atgtatcccc gctccgccta agctctccgc atcaacctgt tcccctgtca ctttttcaat 2037421 caccttcggg ccggtaataa acatccggcc agtctgttca gccataaata taaaatctgt 2037481 gagtgccgga gaatatacag cgcctccagc gcacggccct aaaataaccg atatttgcgg 2037541 aatgactccg gaatataaga cgtttcggta aaatatgtga ccgtatccat ctaatgataa 2037601 cacaccctct tgaattctcg caccacctga gtcattcagc ccgataatcg gcgccttatt 2037661 ttttgctgcc agatccatca aagcgcagat tttcctggca tgggtttcgc caagcgcccc 2037721 tccgtacact gtgaagtctt gcgcaaatac ataaactgag cgaccgtcaa ttgtgccgta 2037781 ccctgtcacg accccatccc ctaacatgcg ctgttctctt gttaacactt gactttccat 2037841 gaaggggtgt aattcgataa agctgtcctg atctagaaga aatatgatcc tttcccgagc 2037901 agtgagcttg cccttttgcc gctgctgagc cagcttttcc cgtcctccgc cttcttctgc 2037961 ctgcttgcgt ttcgtgtaaa aatgatccat gtgctcattc atgctcattg tgttggtctc 2038021 ctttcggttc acaaagctct acaagaacac cgtttgtttc ccgaggggaa ataaacgcga 2038081 tctttttccc gttcgctccc tgtcttggaa acctgtcaat caattgaaca tgctgatcag 2038141 acaatgcttg aagctgttca gataggcagt tgcacaaaaa cgcaatatga tgcagtccct 2038201 gccctttctt ctccaaaaat aaatggacgg ggctgtcagc tgtcaacggc tctatcagct 2038261 caagtttgac gctaccagct tgaaaaaaag caacattcac cttttgctct tcaaccgttt 2038321 cttgatgaag aaatgcaagc cccaatacat tttcataaaa gcttcttgca tcttttatcg 2038381 aaaaaacggc tatcccgata tggtcaagcc tgttcatttt catccctgct ttcgctaata 2038441 gatatcgctt gtccgcccat tcaaaacacg ctaaaatata gacagattgt ttaaggagtg 2038501 aaaatcatgt ctcaaaaact gatgaaaagc gttttgatcg tgattttggg agtttttatt 2038561 ctttcaactg tactctcagg aatcgtcatg tttctataac gataaaaaag caggcgcctt 2038621 attcaatggg aatatcctgc ttttttatca gagctttatg ctcgatggca atctcctcaa 2038681 aagagcggtt gtcgtccgtg atcagcactc tcgttcctac tggtatcgtt tgaaacaaat 2038741 gaacaacctc atcgttatgc atacgtatac agccgttaga cacaaatttt cctactgatt 2038801 cctctcggtt tgtcccatga attccataaa tccgcccgtc cgttcctttc gcgtcaaatc 2038861 cgatccatct tgccccaagc gggttatcag gagatccccc ttcaatattt ttctttctgt 2038921 agtaaggatt ttccgctttt accgttaccg aaaactctcc ttcaggcgtc aaatcatctg 2038981 tttttccagt cgccacacta tacacgcctt ctactttgtt gtcgaggata acagcaagtt 2039041 catttgttcg cttgttgaca ataacatacg gatcacccgg cagcggattt tcgccgagcg 2039101 gccaaatcgg tgaaatcatc atgaaaatcg aacataagaa aaaacgcata agctcctcct 2039161 ttttcattag gttgaccaat gaaggaagag ctcatgcgaa tcatccgagt gatttttgcg 2039221 cttttattcc tttaaaataa cttttaatca ctaaatattg ttccatttcg ccgagaagat 2039281 ggaagagagc ggccctcgct tcaaattcct ctctagtcgc aggaagcggc atctcctcaa 2039341 attcttttct catgtcagca agtcttttca gaaatttgta tgctgtattc ccagggtgta 2039401 tcgcctcccg caaatcatga ataaattcag cgatcatttt tccctgatct accgtgatgg 2039461 agatcgatgt cactttaggg agaaggcgtt cgataatttc aaattgcttt tctctcattt 2039521 taaaataatg ataatgcaga ttttcataac gcaaaatgtg gttttgcaca tctcgatatg 2039581 ccaggttttt agcctccgta atgagctggt gcgtttccgg aatttctttt cctgaccaat 2039641 cttgctcacc agttaacaaa taccgttcga tttctgcaaa aatgacagca aagttatcct 2039701 ctatcttttt gcggtaggca atcagtttcc ggtcaagact aggcatatac aagttcatca 2039761 atagagcgac gccgatgcca accgtaatca gctgaacttc attccagatg aaagtaggcg 2039821 taatgccgcc ggacatgtat aaatgaagga taataacaga actggtgacg ataccctcgt 2039881 taatttttaa cagaaccgtt atcggaatga atatcaaaag aagcgctccg atcacaaacg 2039941 ggtggtagcc aataagctcg aaaaagagat aagaaaaagc aattgccaga cagcatgccg 2040001 aaaagcgggc ccatgaggcc tgaagcgacc gtttttgtgt gatttgtatg cacaaaatgg 2040061 tgatgattcc tgctgatgcg aagttttgca aatgcaataa ctggcttata taaatagcca 2040121 aagctgttcc aagcgcggtc tttattgtgc ggtaaccaat tttaaacatg tcggactcca 2040181 tttctatttg tttcttcaat aaaaaagaag aggcggccag ccttcttctt ttttatattc 2040241 tataatattt tctctaaaaa gtcctgcgct cttttggatt ttggcgacat aaaaaattcc 2040301 ttcggattgc cgtcttcgac aatcattcct tggtccataa acagcacacg gtctgccact 2040361 tcttttgcga agcccatttc atgtgtgaca atcaccatgg tcatgccggt ttcgaccagc 2040421 tctttcatca cctgtagcac ttctttgacc atctctggat caagggcgga ggtcggctcg 2040481 tcaaacagca tgatgtccgg attcatcgca agagccctgg caatcgcgac acgctgtttt 2040541 tgtccgccag acaaacggtt tggatagtca tttcgctttt caaacaaacc gactttgcgg 2040601 agcaggtcct cagctttctc ctgtgcagcc tgttttgatt ctttttttac attgacaggc 2040661 gcgtacatga tgttttcgag aaccgttttg tgcggaaaga gatgaaaatg ctgaaaaacc 2040721 atcccgatgt tttcccggac ctttaatgtg ttggttttcg gcttcgtaat ctctgtgtct 2040781 tttattgtaa tggttccgcc gttaggcttt tccaacaggt ttaaacagcg taagaacgtt 2040841 gatttgcctg agcctgaagg accgatcacg gcaacaacct caccctcagc gattgttgtt 2040901 gaaatgtttt ttaatacttc gtgtttccca aatgattttg acagcttttc aaccttaatc 2040961 attggatttc agcttccttt ctacagcctt gccgataaac gttaaaatca ggacaagcac 2041021 ataataaatc aatcccgcga taatgagcgg ctcaaggtaa ttgtaagtgg cggcgccagc 2041081 ttgatatgcg cgtctcatga catcaccaag cccgatgacg gtgacgatcg ccgattcttt 2041141 tgttaacgta attaattcat tcacaattgc aggtgatata tttttgaagg cctgcggcag 2041201 cagcagatcc ttcatcattt ttccatacgg gacaccgagt gcaacagcag cttctttttg 2041261 ccctttatca atggcattga ttccggctct gataatttcc gatacataag cggcggaatt 2041321 caaagacaat gcgacaaccg cagcccaaaa ctggtcaatt tgaaatccga gcagctgagg 2041381 aaggccaaaa tagacaatca taagctgcag cactaaaggc gtgcctcgga acactgatgt 2041441 ataaaaatca gcgatccaga taaacgggcg gaatgtgctg atcttgcata agcttagcac 2041501 aataccgagt ataagtccga taatagcaga tacaacaaca atttttaatg taattgccaa 2041561 gccttctaat ataaaaggaa tttgggggat cgttgctgaa aaatccaaat tcatagcctt 2041621 tgtctccttt tcttacagga aaaaagtttc ctattcaata aaaaggctca acgaaaaagt 2041681 tgagccgctt ttttttactt ctcgccagtg aaccattttt tcttcaattt ctcaagctct 2041741 ccgttatctt ccatttcctt gagcgcttta ttgaatttgt ctgtcagttc actgtccttt 2041801 ctgaaagcaa ttgctgaacc ggcttcttcc gctttcgcat caggaatcac aaagccttgc 2041861 aggtcatcat ttgatttgaa atacccttct gcaacaatgt cttcaataat cgcggcatcg 2041921 aagcggtcag atttgatttc ctgcaccaaa tcagaaattc tgttgcggtc ttctgtttta 2041981 aaaccatatt ccggagaaag ctctttcccc ttctcttcct gaatagagcc aagctgaacg 2042041 ccaactgttt ttcctttcag gtctttcaaa gattgaatgc cgctgtcttt tttgctgaca 2042101 atcatatggt tcgctgtgta atacacatcg gaaaaatcaa cttgtttttt acgctcaggc 2042161 gttggtgtca ttcctgacag aacgagatcc acctgttttg atttaagcgc tgtaattaag 2042221 ctgttgaagt ccatatcctg cacttcaatt tcatagcctg ccttctttgc cagagctttt 2042281 gccagctcta catcaaagcc gacaatatta tctccttctt tatattcaaa cggtttgtaa 2042341 tccgccgaag tacccataat taattttttc tttccgcttt ctgaacctga attgcttgag 2042401 ccgcacgcag ttaatgcaaa ggtgatgcaa gcagccacaa gtaataagag ccattttttc 2042461 atgatccatt tcccccgtat tcattacttt tggtgtattt gaatatttat tcgttaattt 2042521 gtattttaaa cagtttctca tttttatgca atactatttt taaaaattat ctttaggctt 2042581 atctttccag tgatctcttc tgatattact agataaaaat taaatcgctg tacaatccga 2042641 ttgaataatc ccttaatatt tattcatata tccttggaaa tttatgcaca aaaaaacccg 2042701 ggctgctttg agcatccggg ttgttcgtct tatacttctt cacaatattc ttcaaaggct 2042761 tcctgcagct ttgccactac agccatcggc tcatggcctt caatttcatg acgctctacc 2042821 attttcatga tctttccgtc tttcaaaatc gcaaaggacg gagaagatgg tggataacct 2042881 tcaaaatagt cacgcgcacg cgctgtcgct tctttatcct gtccggcaaa aacggtgacg 2042941 agctgatcag gtcttttatc atagtgaacg gaatggtagg ctgccggtct tgcaattcct 2043001 ccggcgcatc cgcaaacaga gtttaccatg acgagcgtcg ttcctttttt cgtaagtgcc 2043061 tcatccacct cttcggctgt tttaagctcg gtgtatccgg cagctgttat ttcttgtctc 2043121 gcttggcgga caatatcatt cataaataaa ttaaagtcca tgttcaatga agacctctcc 2043181 tttttcatca tctgttctta tgatagcaag gaaacgtcca tatcggcaaa tgactttgct 2043241 tcgccgtgca ctttttttgc tcttcgttta ctgcttacag aaaaagggga ttatataacc 2043301 agaagtaaaa taaaggagca gttgtatatg agccaccgga aagcgttact gattcataac 2043361 ggaaatgccg gcaacaaaaa tatagaaaaa gcacttggtg ctgtggtgcc ggttttatct 2043421 caccatttag atgaggtgat tattaaacag acaaagaaaa aggatgatgc gtatcatttt 2043481 tgccgatcca ttgatgattc tgtcgacacc gtcttcattc tcggcggcga cggcacgatc 2043541 catcaatgca taaatgctat cagcgctcta gaaagaaaac ccgctgtcgg aattttgccc 2043601 ggcggcacgt gcaacgactt ttcaagagtg cttggcatcc ctcaaaatct tgcaaaggcc 2043661 gcggaagcac ttatggcggg aaaaaaaacc agcgtagacg tatgtcagat gaatgaccgt 2043721 tattttttga atttctgggg gatcggctta attgcagaaa cgtcgaatca aatcaacgaa 2043781 acggaaaaag cattattggg aaaaatcagc tattttacaa gtgccttgcg aaccgtctca 2043841 tctgctgcat cgtttccgat gacattaaaa attgatggag aagaaattaa agaagaagcc 2043901 gttatgctgc ttgtgatgaa tggccaatac attggaacga atcgaattcc tctgcccgat 2043961 gccagtattg aagacggctt acttgatgtt ctcatatgcc gcaataccaa cctcaccgcg 2044021 ctgcgggagc tgatgagcat ggaacaaggc tcaattgatc gttttactgg agagttgtcc 2044081 tatgtccagg cttcccgtat cgagattgaa acagacactg ccaaaaaggc ggatatggat 2044141 ggagaagttt atacacatac acccgcagtc attcaggtcc tgccacagca tatcgacatg 2044201 cttgttcccg caaatgaata actgtcataa ggctttagaa agattttgca aatccgttga 2044261 ctctccccta ggaggaggtc ttacagtata agggatacac acttgaaaaa ggggaagtca 2044321 tatggagaag aaaaatatta ccttaactat attattaacc aatttattta ttgctttttt 2044381 ggggatcggg cttgtgattc cagtaacgcc gaccattatg aatgaattgc atttatcggg 2044441 gaccgcggtc ggctatatgg ttgcctgctt cgctattaca cagctcattg tctcaccaat 2044501 agccggacga tgggttgatc gcttcgggcg caagatcatg atcgtaatcg gcctgttgtt 2044561 ctttagtgtg tcggagtttt tgttcggcat tggaaaaaca gttgagatgt tatttatctc 2044621 ccgtatgctg ggcggtatca gcgcagcctt cattatgccc ggggtcacgg cttttattgc 2044681 agatatcacg accattaaaa cacggccaaa agcgctcggt tatatgtcag ccgctatttc 2044741 aacaggattt attatcggcc ccggcatcgg gggattttta gcagaagtcc attcccggct 2044801 gccttttttc tttgcggcag cttttgcact gttagcagcc attttatcaa tcctcacgct 2044861 gcgcgagccg gaacgaaacc ctgaaaatca ggaaataaaa ggacagaaga caggctttaa 2044921 acgaattttt gcccccatgt atttcatagc ttttctcatt atcttaattt cgtcttttgg 2044981 tttagcatca tttgaatctt tatttgcatt attcgtggat cataaattcg gatttacggc 2045041 cagcgacatt gccattatga ttacaggagg agcgattgtt ggcgccatta cgcaagtcgt 2045101 cttattcgac cgcttcacaa gatggtttgg cgaaattcat ttaattcggt acagcttaat 2045161 tctctcgacg agtctggtat tcttgctgac aacggtacat tcatatgttg cgattctgct 2045221 ggtgacagtc accgtatttg tcggatttga tctcatgcgg cctgcggtaa cgacttacct 2045281 gtcaaagatt gcgggaaatg aacaggggtt tgccggcggt atgaattcaa tgtttacaag 2045341 tatcggcaat gtattcgggc ctattatcgg cggaatgctg ttcgatatag atgtaaacta 2045401 tcctttctac tttgcaacgg tcaccttagc catagggatt gcactgacca ttgcttggaa 2045461 agcgcctgca catcttaaag ccagcacgtg ataagaagcg cattctttgt gtactgcaaa 2045521 gaatgcgctt cttctttata ctgatgatag aaggagtgat ggcatgaagg aatcgtatta 2045581 ctcaattggg gaagtatcaa aactggcaaa cgtgtcgata aaagcgctcc gttattacga 2045641 taaaattgat ttatttaaac cagcctacgt cgacccggat accagctacc gctattatac 2045701 agattctcag ctcattcatc tggatttgat caaatcattg aaatatatcg gcacaccttt 2045761 agaagagatg aaaaaagcac aggacttaga gatggaagaa ctgtttgctt tttatacaga 2045821 gcaggagagg caaatcaggg agaaattaga ctttttatca gccctggagc aaaccatttc 2045881 attggtgaaa aagcggatga aacggcagat ggaatatccc gcgctcggtg aggtgtttgt 2045941 tttagatgaa gaagaaatac ggatcattca gacagaggca gaaggaatcg ggcctgaaaa 2046001 cgtgctcaac gcctcctaca gcaaattaaa aaaatttatc gagtcagcag atggatttac 2046061 gaacaatagc tacggcgcta ctttctcttt tcagccctac accagcattg atgaaatgac 2046121 ttaccgtcat attttcacac ctgtattgac gaataaacag atttcatcaa ttacgccgga 2046181 tatggaaatc acaacgatcc ctaaagggag gtatgcgtgt atcgcgtata atttttcgcc 2046241 tgaacattat tttctcaact tacagaagct tatcaaatat atcgcggacc gccaattaac 2046301 agttgtcagt gatgtatacg agttaatcat accgattcat tactccccga aaaaacaaga 2046361 agaatatcga gtcgaaatga aaatacggat cgctgaataa taaagcatag aaaaagagca 2046421 ttttttgaaa caaaacttca aaaaatgctc tttttgctta tttagtaaac agatgtcttc 2046481 tcgtcaatcg attctaaaat ttgtttcact cgtccgagga atcgtccgca cacgagaccg 2046541 tcaagcactc tgtgatctaa tgacaggcac agattaacca tgtctctgac agcaatcatg 2046601 ccattgtcca tgacaaccgg gcgtttgacg atggattcta cttgaagaat cgcagcctga 2046661 gggtagttga taatgcccat cgactgaaca gacccgaacg aacctgtgtt gttgacggta 2046721 aacgtgcctc cctgcatgtc atctgcagtg agttttccgt ctcttacttt tttagctagg 2046781 ccggtaatgt ctttcgcaat gcctttaatt gttttttcat cagcgttttt aatcaccgga 2046841 acaaataaag aatcctctgt ggcaactgca attgaaatat tgatatcctt tttctgaata 2046901 attttgtccc ccgcccacat gctattcatt tgcgggaatt cttttaacgc ctgagcgacc 2046961 gcttttacaa aaaaggcgaa gaacgttaaa ttaaagcctt ctgtcttctt aaaagaatct 2047021 tttatactgt tgcgatatgc aaccatattt gtgacgtcga cttccatcat cgtccaagca 2047081 tgcggaattt ctgttttgct tcgcttcata ttggaagcaa ttgcttttct tacacctgtg 2047141 acagggattt ctttatcacc ggctgcagac gcaggatatg acgtctcttc ttttggctca 2047201 ggttttgatg cagacttcgg tgcaggagct gctgttttca gctcctcagg attctgttct 2047261 tgcacgccgc ctgtttcaat taagcgctga atatcttttc gtgtgatgcg cccgccggca 2047321 ccagttcctg tcacttgatc gaggtcaatg ccgtgctctc cggccaaacg gagaacagct 2047381 ggcgagtagc gctttttatt gggctgatcg gctgctccag cactttttgc aacagggttc 2047441 tcagcggctt ctgatgctgc tggctgttct tgtttttgtt cagccggatt cgcgccttct 2047501 gtttcaattt tgcaaatcat ttctccgact tgcagggttt ggccttcttc tcccacaagc 2047561 tctgttatcg taccagtaaa agaagacgga acctctgcat ttaccttatc tgtcatgact 2047621 tccgcgatcg gatcgtattt gttcacttta tcaccggggg cgacaagcca tttgctgatc 2047681 gtcccctctg ttacgctttc tccaagctgc ggcatcgtca tttgttcaat tgccatgatt 2047741 gtatcctccc ttacgtcttt aaaactccgc taattctctc atcgccgctt ccactttatc 2047801 agggttgacc ataaagtatt tttccattgt cggcgcataa ggcatagccg gaatatcagg 2047861 acctgcaagc cgtttgatcg gcgcgtctaa gtcgaacaga caatgctcgg atataattgc 2047921 ggctacttcg ctcatgatgc tgccttcttt tgtatcttct gtgaccaaaa gaacctttcc 2047981 agttttggac gcagcttcga tgatggcttc tttatcaagc gggtaaactg ttcttaaatc 2048041 caccacatgc gctgaaatgc catctttttc gagacgttct gcagcttgta aggcgaagtg 2048101 gacacacagg ccgtatgtga tcactgtgat gtcgtcgcct tcccttttta cgtccgcctt 2048161 gccgattggc aggacataat catcagccgg aacctcgccc tttatcagac ggtatgcccg 2048221 cttgtgctca aaaaacagca cggggtcttc gtcacgaact gcggctttta agagcccttt 2048281 cgcgtcatat ggtgttgatg gcatgacaat tttcagtccg ggctggttgg cgaaaattgc 2048341 ttcgactgat tgagaatgat acagggctcc gtgcacgcct ccgccgtatg gcgctctgac 2048401 gacaatcgga cagctccagt cattgttgct gcggtagcgg attttagccg cttcagaaat 2048461 aatttggttg actgccggca taatgaaatc agcaaactgc atttcagcaa tcggtctcat 2048521 tccgtacatt gccgctccga taccgactcc tgcgattgca gattcagcaa gcggcgtatc 2048581 cataacgcgc tcttccccaa attgttcata gagtcccgct gtcgctttaa acacaccgcc 2048641 ttttcttcct acatcttccc caaggacgaa aacgcgagaa tctcgttcca tttcttcttt 2048701 catcgccaaa ttgattgcat caatatatga cattactgac atttgttctt cctccctact 2048761 tcgcataaac ataatcaagc gctgactcag gagctgcata tggggcgttc tccgcttcat 2048821 ccgtcgcttc atttacgatt gccataattt catccagcat ggtttgttct atctcatcgg 2048881 acagcaggcc tgtttccttt aagtaagctt gataagtaag caggggatca ctttttttcg 2048941 cttcctctac ttcttcacgg cctctgtagc tgctgtcatc gtcatcactg gaatgtggtg 2049001 taaggcggta agaaatcgtt tcaattaatg tcgggccttc tcctctgcgt gccctttcgc 2049061 gtgcttcttt aaccgcttga taaacttcca gcggatcatt tccattcaca gttacgccag 2049121 gcatcccata gcctatggca cggtcggaaa tgttctcaca tgcgacttgc ttatcgtaag 2049181 gcactgagat tgcgtatttg ttgttttcac acatgaaaat aaccggcagc ttatggacag 2049241 cggcaaagtt tgccccttca tggaaatcgc cttggtttga agacccttcc ccgaatgtaa 2049301 caaaggctgc gatatccttt ttctccatac gtcccgcaag cgcaataccg actgcgtgcg 2049361 gcacttgcgt tgtaaccgga gatgatcccg tcacaatgcg gtttttcttt tgtccgaaat 2049421 gtcccggcat ctggcggcct cctgagttcg gatctgctgc ttttgcaaac ccggacatca 2049481 ttaagtcctt tgctgtcatg ccaaacgcga gcacgacacc catgtctctg tagtacggca 2049541 atacataatc catttcacgg tcaagtgcga aagccgctcc tacctgtgct gcttcctgtc 2049601 cttgacaaga gattacaaat ggaattttgc cagaacggtt taacagccac attctttcat 2049661 cgatttttct tgctaacagc atggttctat acatatcaac ggcttcctga tcagtcagcc 2049721 ctagtgcttg atgtcggttt gtactcattc aagcccctcc tttatgcttt taaaaatgaa 2049781 tggctttgcc atctgcggca agcgcagctt ctccaattgc ttcagaaagc gttggatgcg 2049841 ggtgaatcgt ttgcccgacc tcccacggtg ttgcgtccag cactttggca agacccgctt 2049901 cagaaatcat gtcggtgaca tgcgggccaa tcatatgaac gccgagaata tcatctgtat 2049961 ctcggtcagc cacgattttg acaaaaccgt cgctttcacc gtatacaagc gcttttccaa 2050021 tcgccataaa tgggaacttg ccgattttga cattatgccc gttcgccttt gcttcgtctt 2050081 cggttaagcc gacactggca gcttcagggc ttgagtaaat gcacttcggc acaagcgtcg 2050141 gatcaagcgg atgcggattg agacctgcaa aatgctcaac agcaataatt ccctcatgtg 2050201 aagcaacgtg agctaactgc aggccaccga ttacgtctcc gattgcataa atatgagatt 2050261 ccttcgtttg gcagctttca ttgactgaaa tcatgccatt ttcagtaaca atatcggtgt 2050321 tctctaggcc gatgccttcg atatttgcct gtctgccgat ggaaacaagc attttctcag 2050381 cagaataggt aacggtttct ccgtcttttt ccgcttgtat gctgatatcg tctgatgttt 2050441 ttgtcattgt gtcaggcagc acttttgccc ctgttatgaa ctggatgcct tttttcttaa 2050501 gaagactttc catttctttt gaaatctcta gatcttcagt cggcaatatg cgatccgcgt 2050561 attcaataac cgttacctta acgccaaaat catgaagcat agacgcccat tcgataccga 2050621 taacccctcc gccgacaatg atgattgact gtggcagctc ctccatttgg agcgcctcat 2050681 ctgaagtcag tacagactta ccgtccactt caagacccgg aagcattctc ggtcttgatc 2050741 ctgttgcaat gatcacttgt ttcgggatca gcatgtcatt ttcttcgcca tttccccgct 2050801 caacagaaat tgttcccggc agcggagaga agattgacgg tccaaggata cgtccatatc 2050861 cggtgtacac gtcaattttt ccttttttca ttaaatgatt tacacccgct gcaagcttat 2050921 caacaacggc ttgcttacgc tgctgcactt tttcaaagtt gagggacacg ccagccgttt 2050981 ccactccgaa ttgatcggct tcacgagctg tccggtatac ctctgcgctt ctaagcagcg 2051041 ctttactcgg gatacagcct ttatgcagac atgttccccc gagtttttcc ttttccacaa 2051101 cggctgtttt taagccgagc tgagcggctc tgatggccgc aacataaccg ccggtaccgc 2051161 cgcccagaat gactacgtca tactcagttg ccatggtgac tcactcctgt ctgtctattc 2051221 aatacgatat tgtttggatt gctcttcgcc ctgcaatact cttagcgccc cttgggcaag 2051281 agactgcagt tcattttcac ccggataaac taaaacgtct gaaatccaat ctatgtatga 2051341 tctgatagca gaaacaaagc tttttccgta cgcaaggcct cccgtcagca caatcgcttc 2051401 aacttcgcct tttaacgccg cgctggctgc cccgatttcc tttgctacct gatatgccat 2051461 ggcatcataa atgaagcggg ctttttcatc gcccccttga atcatctgtt ccacttttac 2051521 tgcatcattt gtaccgagat agcctaaaag tccgccggtg ccaacaagct ttttcatgat 2051581 ttcttctttt gtatattccc ctgaaaaaca tagatcaaca agatctcccg caggcactgt 2051641 tcctgctcgt tcaggactga atggtccctc gccgtgcagg ccgttattga catccaccac 2051701 tcgcccgcgg tcatggacgc caattgtaat acctccgccc atatgggtaa taatcatttt 2051761 catgttctca tatcgtttgc caagggaggc tgccgcttta cgagcgacag ctttttggtt 2051821 taacgcatgg aaaatgcttt tcctttcaat ttcaggcatg cctgaaactt tcgcaagcac 2051881 tgacatttcg tctacgacaa cagggtcgac gatatacgaa gggatattca ggccgtcagc 2051941 gatttcccgc gcgataatgc cgccgagatt agaagcatgc tgaccggcgt agccgctttt 2052001 caaatcctca atcatctcat cattcactac gtaggtcccg ccttcaattg gccggagaag 2052061 gccgcctctt gcgcagactg catcaaactt tgaaatattg attccctgtt catgaagcgt 2052121 ttcgagaata tggtttttac gaaattcata ctgatcaata attcggtcaa atcgctgcag 2052181 ctcttctatg ttgtgtctca atgttttttc aaaaatgctt ctttcgttat gaaaaacacc 2052241 gattttcgtt gaagttgagc ctggattaat tgtgagaatg cgtttttcgt catgtagcac 2052301 tttcataacc tccagatcaa tttcttaacg tctgcttaat acactgtggc cgttttgcaa 2052361 aaactggctt cttgagcggc gcatgcgttc aatccgttcc tctgctaagc ggtcagccgc 2052421 taaatatgca ggaatgccgt cacgctgaga aatctcaagt acacgctcga tattgccgta 2052481 aatgccttca acttttttca atgcacgttc tgcattatag ccgtaaagct catctgccac 2052541 gttgatgaca ccgcccgcgt taatcacgta atccggtgca taaacgatgc ccatttcgtg 2052601 aatttgatca ccatggcgtg tctcttttaa ttggttgtta gccgcacctg cgatcacttt 2052661 cgccttcagc tgtttaatgg tgtcgtcgtt aatagtcgca ccaagggcac acggcgcata 2052721 aatatcgcag tcttgtgaat aaatgtcatc aggatctacc gcacgggcgc caaaatcttc 2052781 aactgcacgc tgtacagatt gtttgttgat atccgtaacg attaagtttg ctccttcttc 2052841 atgcaggtgg cggcaaaggt tataggctac gttcccaaca ccctgtacag caatggtttt 2052901 tccttcaaga gagtcggttc cgaaagcagc tttagctgct gccttcattc ctctgtacac 2052961 cccgtacgct gtgactgggg acggatttcc agaagagccg aaagcaggag aaatccctgt 2053021 gacatagtct gtctcatcat gaatgatatc catatcctcg accgttgtgc ccacatcttc 2053081 agccgtgatg tatctgccat tcagtccttg aatatagcgg ccaaacgcgc ggaacatttc 2053141 ctcatttttg tctttgcgcg gatcgccgat aatgactgtt tttccgccgc caaggtttaa 2053201 gcctgccgcc gcgttcttat aggtcatgcc tcttgccaat ctgagcgcat cttcaattgc 2053261 cgcttcttca ttttcatatg tccacattct cgttccgcca agcgccggac caagcgttgt 2053321 atcatgaatg gcgataatcg cttttaatcc agattgttca tcctggcaga ataccaattg 2053381 ttcgtaatcg tatttctcca tatatttaaa aagttccatg ttcgttcctc ctaatgtgtg 2053441 tattcttcag atgcgcatat tgccagcgca atggaataca gtttattttc agcagagtcc 2053501 gctctgcttg ttaaagcaat cggtgctttt gctcctgtaa tgacagccgc cacgctggcc 2053561 ttggcaaaat aaatcagtga tttatataaa atattgccgg cctcaattgt tgggacgaga 2053621 aggatatctg cgttgcccgc tacgtctccc gaaatttttt tctgggccgc ggcaatttgt 2053681 gaaactgcgt tatccaaagc aagcggtcca tcaacaatgc agcctttgat ctggcccctt 2053741 ttgtacattt gagctagagc agctgcattc acggtcgctt ccattttagg gttcaccgtt 2053801 tcgaccgctg caagggcagc tgcttttggc atattgttcc ccactgcatg ggccacatga 2053861 acggcatttt gcaaaatctg ccggagctct tccagcgaag gagcaatatt cattgccgaa 2053921 tctgtcacaa acatcagccg gtcaaaatcc ggtatatcga agacagccac gtgagaaagg 2053981 acacttgctg accgaagccc ctcctgtctg ttcaataccg ctttaagcaa aacagaagtc 2054041 ggcacattgc ctttcattaa aacgtccgct gttttatgat gcacagcacg aaccgctaat 2054101 ttcgccgatt cctcaggagt attggcatgg acgatttcca cttgatgccc ttgcatggat 2054161 gatgtcagct cgttcagttt tttgctgtcg cccgttaaca agaaacgggc ggataggtgc 2054221 tcggctgcca gctttacagc ccggatcact tcctcatcct cagcatgagc aaccgcaatg 2054281 gtcttatttt tgtgtatcga cgctttgccg attaaatctt tcagcttcat ctgttaccac 2054341 ctttcttgtt tcgactccgc cttttattat gcaagttcca tgccagctct taagggtgct 2054401 gtcataccag gtataccgaa acattcgtgc agatgtttgc gtttattctg caaattattg 2054461 catgccttca tttgcaaggc catatttatc cattttgtaa tataaattcc gaatgctgac 2054521 accgagagct tttgctgttt ttgtccggtt aaaatgatgc ttttcaagcg tttgctggat 2054581 caaatgcgct tcaaattttt ctactgcgac agacagcttt tcgccttcaa tatccggaaa 2054641 atcaaaacct gttccctgat ctgtgtcatt ttctttttgc tcaagttcga atacaggcaa 2054701 gtgatctttt tcaatccatt ccatatgcgg attcagaaaa atcatggctc gtccaaggac 2054761 attttcaagc tcccggacat tcccaggcca atggtaggca gataaggcgc gcaaggcttg 2054821 ctgtgagagc ccttttacat tcctgccgta atcccggttg atcttttgga taagtctgac 2054881 gctcaatgct tcaatgtcct ccaaccgctg ccgcaaaggc gggatggaga tcggatagcg 2054941 attgatccgg taatacaggt cttcccggaa tgttccgtcc gccatcgcct tttcaatatt 2055001 tacatttgtc gccgcgatca ctctgacgtt gacagggatc gctttcgtgc cgcccactct 2055061 gacgatttcc ttttcttgaa ggacgcgtag caatttggcc tgcatatttt gtgtcagctc 2055121 accgatttca tctaagaaaa tactgccgtt atttgcttcc tcaaataaac cctttttacc 2055181 gccgcgcttc gctcctgaaa acgcaccatc ctcatagccg aacaattctg attcgagcag 2055241 gttttcagaa agggctgcac aattcacgcg aataaattta ttgtatttcc ggtcactttc 2055301 gttatggatg gcatgggcga acagttcttt tcctgttcct gattccccgc gcagcaagat 2055361 ggttgccggt gttttcgcac cgagcttcgc ctgctcaagc gcaaccagca tttgctcgct 2055421 tttgccgata atgtcgtcaa acgtgtattt cgcttcaagc gtgcgaataa tttgtctggc 2055481 gcgattaagc tccgctgtca gcattttaat ttcggaaaca tcgtgaatca cgccgacgct 2055541 gcctttcaaa atcccgtcca caatcaccgg tgctacatta acgatcactt ctttttcatt 2055601 cgggccgacc ttcattctga caccgcggac aggacgtctt gtttcaagca cctttaaatg 2055661 catgctttcg ccttcggaaa tatcagtgtt tgcaggcttg ccgatgactt ctttttcaga 2055721 aagccccgtc attttcgtat acgctttatt gattagcagg ccgatgccgt tttcatcaac 2055781 gacagaaatc gcctcatcgg aggattgaat aattgcctcc agcatcgtac ggacctgctt 2055841 taagttggtc acttcctctg ccagctcgac cgcatcagtg atatctttaa acacacaaag 2055901 agccccgagc agacgtccgc cttcatcaat aatcggcagt cttgtggtca caatttgcaa 2055961 atgatcgcct aacagctgct tctggttgta ttcaggcact cttgttttta aaatccgcgg 2056021 catcttagtg ctcggaatca cttcttttat tgggcgccca atgacttcct cacgtttttt 2056081 tccgaccatt ttttcggcca tatggttaaa gagaatgatt tcttcattga tatcaataaa 2056141 aatcattcca tcatgggtgg aattaaaaat tctgtcatat ttataggttt gctcttttag 2056201 catttgaatc aggtgctgct tttcttccat cagctgaaaa acgatgtatg ccatttttcc 2056261 cggcatgaca atggtatctt catgctttct ttgaaggagc tcgtcaaaca cggcttgatc 2056321 gccggtagta tgaatgacga tatccggttt ttgttgtatg taaggtttcc aatcagatga 2056381 tacggcaatc ccatactgtt ctgcttcttt caatcccggc gcctcggggt ctttgtcaac 2056441 tacggcaatg atatctatga tggctgtttt aatcagaata tgtaataacg ccgttcccct 2056501 tttgccggca cctactatca gtaccttttg catcccgata cccctttgta tgaaaaaatt 2056561 tgcacaccta tttattccgt tgcaataatt tgcacaaccc tatgttacca cgttttcttc 2056621 tcttgacaaa atattttttc cgctggacaa taaaggaaat gaaaagataa aggggttttc 2056681 tgaagatgag ccgacttctt gcgcttttaa tattagtcat ccccggggct atttctgctt 2056741 taggcattaa actgatgaga gatacacttt tcggccatac aatcaagcca ttttcagctc 2056801 tttggctcca agggttgtca ggattcatct tttttgcgat cggcctctat gtgctggccg 2056861 ggttcatttt atacagagac agaaaacgca atcaagtcag cccgcgattc agaaaacgat 2056921 agctgaaaaa aagccggaga atgctccggc tttttttgtt gcattattcg tcaggcaaaa 2056981 cggtcttggc aatcgttttg tctaacgctt catagtcata ataagaaatc gtatcgtaca 2057041 gttcttttcg tgtctgcata tcatgaagtc cttctttttg tgagccgtgc tccttcatca 2057101 aaccaaacat ccgctcacaa gcttttgccg ccgctcgaag cgaggtgaca ggatatatca 2057161 ccatgtgaaa ccccatatct tcgaattcat cggcacgata atatggcgtt ttcccaaatt 2057221 cagtcatatt cgcaaggagc ggaacgggga tacgctcagc aaactggcgg aattcattct 2057281 ccgcctgtag cgcttccggg aaaattgcgt ccgctcccgc ctcaatgtaa gcctctgaac 2057341 gttttattgc ggcatcaagc ccttcctgcg ccctggcatc agtacgggca acaacaataa 2057401 gggagggtgc cgcttgttta atggctttta ttttttgcgc catttccttt atcggaacta 2057461 gctgtttgcc atttaaatgt ccgcattttt ttgggagctg ctggtcttcc atttgaacgg 2057521 ctgctaccct ggcttcaagc atctcccggg ctgttcgggc ggcatttaag acaccgccaa 2057581 atcccgtatc gatatccaca agcaaaggca gatcagctgc acgcacaaga tctttggccc 2057641 gttcagctat ctctgccgat gtgatgatcc ctaaatcagg cagccccctg ctggctgtat 2057701 aggcagcacc ggacaaataa atagcagaaa aaccggcttc tttcgcaagc aaagcggcca 2057761 tcccgtcatg ggcgccggga atttgaagaa tgtccggtgc tgacatcagc ttgcggaaac 2057821 gcccggcaag ctcctcttgt gacgattgct tattgacgat ccacgacatg aaacaaaatc 2057881 ccccttttac atgcagaaca tgtctacgaa ttcatttacg cgcatcgttt gtaatgtctc 2057941 atagctggta cagcgctcat aaatgtgttt gtgctgttta tcaggaaaat gggttttgag 2058001 attgtcagaa aacttttcca gcagtttcgg cactgcttcc tctcttcgaa aacgatggcc 2058061 gaggggaaac tcacattcca ccatttccgt gctcgttcca tctttaaaat gaacctgaac 2058121 ggcatttgag atggagcgtt tatcaggctt caaataatcc tcggtatatg ttttattttc 2058181 agtcacttcc attttatcac gaagtttatc tattctcgga tcattcgctg tttcagcttc 2058241 ataatgctgt gcggtgatat caccaaaaag caaaccgatt gctgtaatgt attggaggca 2058301 gtgatcacgg tctgccggat tgtggagcgg gcctttttta tcaatgattc ggatagctga 2058361 ttcatgcgtt ctgatgacaa ctcggtcaat ctcgtcaatc cggttcttta cctgcgggtg 2058421 aagaatgacg gcggactccg ccgctgtctg ggcgtgaaat tccgcaggat aagacacttt 2058481 aaataacaca ttttccatga cataagcgtc gagcggacgg gcaagcttga tctctttctt 2058541 attgaataaa acgtcttgga acccccaacc cggtgcactc aaggctgtcg gataacccat 2058601 ttcccctttt aacgacatca gcgccaaatg aacacctctg ctcgttgcat ctcctgccgc 2058661 ccatgattta cgcgagcctg tattcggtga atggcggtat gtcctcaatg ctgcattgtc 2058721 aatccatgca ttcgaaagcg catttttgat ttcttctctt ccgccgccca aaagctttgc 2058781 tgcaacagca gttgtcgcaa ctttgacaaa cagcacatgg tcaaggccaa ctcgatttaa 2058841 gctgttttct aacgccagca caccttggat ctcgtgtgct ttgatcatca tctcaagtac 2058901 gtcgcgtacc gttaacggct cttttccttc agacagcctc actcttgata cataatcagc 2058961 agcggcaagg attcctccca agttatcgga tggatgcccc cactccgccg ccagccacgt 2059021 atcgttgtaa tcgagccagc gaatcatgca gccaatatta aacgctgccc tcacaggatc 2059081 gagaacatat gacgttcccg gcactttgct tccattcggc acagtcgttc ctggaacaat 2059141 cgggccaagc agctttgtgc attccggata ccgtagcgcc aagattccgc agcccagggt 2059201 atccagcaat acatgccccg ctgttgtata cgcttcggca ctagtaatct ctttctcaag 2059261 cacatagtct gtgatttctt cgataacacg atccgttttc ggcattctac cagctccttt 2059321 catgattttg tttgatatcg cgggcccatg taactgacac ggggacggaa gagccgatta 2059381 ttggcatgct gttcgatcac atgggcgcat aaaccggacg ttctcgcgct gaaaaagatc 2059441 ggcgtatata aaggaatcgg tatgccgagc atccaataca ctggggcagc atagtaatcc 2059501 aaattcgggt aaagcccttt ttccttctcc atcagccgct cacccgcttc gcacatctca 2059561 tataaacgat ggtcaccggc tttatcgcat aattgctgca gcgcctcttt catcatgagt 2059621 gctctcgggt ccattttttt catatacacc cggtggccga agcccatgat tttttctttt 2059681 cttttcagtt ttgtttgcaa aagctgctca aaatcagatg tcgtttttgc ctccaaaagc 2059741 aaatacatca cagcttcgtt tgctcctccg tgaagattcc ctttcaggga agcgacagcc 2059801 ccagtcaaag ccccataaag atctgaatgt gtagatgcaa tgaccctggc cgcaaaggtt 2059861 gaattcggca tctcatgctc actgtacagg acgagcgacc ggtcaaaaat ctgttcttcc 2059921 aatgaagacg gcaatttccc tgtcatcatg tagagaaaat tcgcactgta ggatagggtt 2059981 tgaagcggaa gaatcggttc tttcttatta atgatcctgt agctggcagc agtgagggca 2060041 ggcattttcc caagaagctg ataggcgcgt tctttgtttg cggaaggaga ccgatcatca 2060101 atttgccgat catagccagc aagtgccgac aggccggtac gcagaccatc cattggatga 2060161 gtgtcctcag ggagcagctc aagcagacgg agatgatcag caggcaggct tgaggcactg 2060221 tttattttac gttccagcgt ttccatttca ctttcttctg gcagcctgcc ctccagcaat 2060281 aaatggacaa gctccagata gctttttgtt tcagaaagtt ctattaaatc atagcctctt 2060341 atcaaaatct ggctggactg cgtgtcaaga taagaaatat gagtttctgc cgcaatcaca 2060401 ccgtccaacc ctggagaata atgctgtttc tcctccatat cctcaacctc cgtttttgcg 2060461 ttttttgtct atcaggttcc gccaagcaaa tacttggaaa taatcagtct ttgaatctcg 2060521 ttcgtccctt cataaatttg cgtcaccttt gcatcgcgaa gcaggcgctc aactggataa 2060581 tccttcatat agccatatcc cccataaatt tgaacggcgt ctaacgccgc ctttacggct 2060641 gcatcggaag caaattgttt agccatagac gcttcttttc cacagtttag gccgcggtta 2060701 tgaaggtctg cagcgtggta gacaagatgt cttgccgcct cagctctagt cgccatatca 2060761 gccagcttaa atgatatgcc ttgattggct gcaatcggcc ttccaaattg cactcgctgc 2060821 ttcgcataat caacggcatg ctcaagagcc gcctctgcaa ttccgagggc ctgtgccgca 2060881 atgccgatcc ggccgacatt taaattcgcc atggcaatgt gaaagccatc cccctctttg 2060941 ccaagcaaat tggcttcagg cacttctgca ttatcaaaaa tcagttccgt agtattggag 2061001 ccataaagcc ccagctttct ttcttttttt ccaacggtaa aaccgggtgt gtttttttca 2061061 acaataaaag ccgaaatccc gtgcctgcct tgatctggag ctgttaaagc aaatgtgata 2061121 tagatatcag ctgctccgcc attcgttatg aatattttcg atccgtttaa taggtatttg 2061181 ccgttctttt tgattgctgt tgtgcggagg ctcccggcat ccgaccccga gtgaggctcc 2061241 gttagtgcaa atgcgcccaa atggtctcct gacgcgagat ttggtatata tttcatcttc 2061301 tgttcttcgt tgccgaaata cagaatcgga ttcgtgccga ctgaggtatg aacggagaga 2061361 atcacgccga cagccgcgct gattctagaa atctcatgaa ttgccaaaat ataagaaaca 2061421 acgtccgctc cagcaccgcc gtattgttcc ggcaccggta ttcccatcag tccgtgttta 2061481 cccatttttt tgatcagctg aaagggaaat tcgtccgttt tctccatgat ttccgcagcg 2061541 ggagcaattt cttttcgtgc aaaatcacgc accatttttc gcatcatgac ttgctcttgg 2061601 gttacatgca actcggccac ccccggatgg aatagacttc aggaagtctt ctcctcatag 2061661 tcataaaaac cgcgtccgct ctttttgcca agccagcctg ctttgacata cttgcggagc 2061721 agcgggcaag gacggtattt ggaatcgcca aggcctgagt gaaggacttc cataattgat 2061781 aaacacgtat ccagtccgat aaaatccgct aatgcaagcg gacccatcgg atgattcatg 2061841 cccagcttca tcacttcatc tattgcctcc ggcttcgcca ctccctcata cacgcaatag 2061901 atggcttcat taatcattgg aagaagcaca cggttggaaa caaacccagg aaaatcattg 2061961 acttctaccg ctgttttccc catcttttcc gctaatgcca taacatctaa ggccgtttct 2062021 tctgatgtag ccaagcctcg aatcacttct accagcttca ttacagggac gggattcata 2062081 aaatgcatgc caataacccg ttgaggccgg tttgttacag cagcgatttc tgtaataggc 2062141 aaggaagatg tattgctggc caaaatcgta tgaggcgggc aaatgcgatc aagtgtttta 2062201 aacatctcag tttttgccgc catgttttct gcgatagcct caatcacaat gtccgcatgc 2062261 tctgcctcct caagtgtttg agaaatcgaa atgcggttga ttacgctctt cacttccgtc 2062321 tcggtccttt ttcctttctc agcatcacgg gccagctgtt tcttcagccg tttcaatcct 2062381 gcctccgcgg cctctggatt cacatcatac atccgcacat aaaagcccgc gtcggcggct 2062441 gtttgagcaa ttccgctccc catctgacct gcgccagcta ccatgatttg tttgatttcc 2062501 attcaaatcc cctttttcat catgttttaa tgaacctgca ctaagacggc gtctccctgt 2062561 gctgccccgc tgcaaatagc ggcaacgccc agaccccctc cccgtcgctt taattcataa 2062621 acaagcgtca tgagaattct cgcaccgctc gcgccgatcg ggtggccgag cgcgatcgca 2062681 ccgccattca catttacttt ttcaagatcg aaacctacga ttttttcaca tgtcaaaaca 2062741 actgaagcaa aagcttcatt tacttcaaac aagtcaatat cttggacagt taaaccattc 2062801 tttttcagga gcttgttaat agcaaaccct ggcgctgccg ccagctcgtg cgctggcatt 2062861 cccgtagttg aaaaaccaag aattgtagcc agaggccgtt tgccaagctc agcagctttt 2062921 tcctcagaca tcagcacgaa cgcgccggct ccgtcattga ctccaggagc attgccggct 2062981 gtgatagaac cgtcacttgc ataaatcgga gcaagttttg cgagctgatc cagacttgtg 2063041 tcacggcgaa tcgcttcatc tttatcaaca acgtttggtt ttccttttcg accgatccag 2063101 ttgacgggaa caatttcatc ctgaaacttc ccttcatcgg cggccttagc tgcccttgca 2063161 tgacttctca acgcccattc gtcctgctct cttcgtgaga ttgcatattc cttggcagct 2063221 gtatttccgt gaacagccat gtgcacctcg tcaaatgcgc acgttaatcc gtcatacacc 2063281 attaagtccc taagctcgcc gtcccccatc cgtgctcccc agcgcccggc gggaacggca 2063341 tacggaatat tgctcatgct ttccatcccc cccgcaacaa gtatgtccgc atcctgcgcc 2063401 cgaatcattt gatcacataa agtgacagcg cgaaggccgg aagcacagac tttattcagt 2063461 gtttctgacg gcacactcca aggcattccc gccagacggg cagcttgacg ggaaggtatc 2063521 tgccctgagc cggcctggac aaccatgccc atgacgtttc cttctacatc atctccagag 2063581 actccagcct gttgcagcgc ctccttcatc acaatgcccc caagctcagc agctttcacc 2063641 tctttcaaaa ctccgccgaa tttgccaaat ggagttcttg cagcacttac aatgactgtt 2063701 ttcctcatgg tttcacctca ttcagaagat agacagcgct tacaatttct agttgtcttc 2063761 tatgaatgta tgctttgaaa cgggcatgaa tgaatgaaaa aagaaggctg cgtcaaacag 2063821 cctccttcta acaactattc atttttcagc aatgccgaag ccttttctgg aaagtcggta 2063881 aacatgccgt ctgctcccgc ttcaatgaga cgcttcatat cttccggacg attgactgta 2063941 tacggcctta ccttaatcaa accgttcctc attttcttca gtacttcatc tgtgacccct 2064001 gggctgttta tcttcgggtg atagccggaa gccggaatag acgcgatata tcgatctgcc 2064061 tgataaagca catctgaagt taatactgcc cgttcgatat gcggtgcaag ccgggcgcac 2064121 agcgccaagc tgtcatgatt aaacgtggat aggatgactc tgtcctctac attaaatcgc 2064181 ttcactgcct ccagcacttt ttcttccatt ccctcatagc ggatcacgct gttttttaat 2064241 tcaatgttga tgagaaaatc cttttttacc gcccacgaga gcacatcttc tagcagcggc 2064301 acttttatat cgctgtacgc ttgatcgtga ccagcggccg cattcgcagt ctttacctca 2064361 tcataggctg tatccttcac gaatccttta agtgatgtcg tgcgattaag tctttcatca 2064421 tgaattacaa caatgcgtcc gtctttcgtc agctgtacat caagctctat cccatccgct 2064481 ccggcttcaa ttcctttttc aaatgcaagc attgtatttt cgggaaattg acctgatgcc 2064541 ccccggtggg caaaaatctt tgtcatcgtt tcacctcaaa ccctaaagtt ttctccatta 2064601 tacttatttt gtcggctcca ctctaggatt aaggctgtat caatctactg atcataataa 2064661 gaatcaatgc cattgacaat cgcatctgcg gccttttgct ggtattcttc acttcccagc 2064721 ttgtccgcgt cagagctgtt cgtgataaac ccaagctccg ccaacacact tggcatttgt 2064781 gaatatgtaa tgacgtaaaa gtctgattct ttcacgcccc tgtctctcgt ttgtaaggaa 2064841 gaaacgagct gtgactgaat atcggatgcc agacgccggc tgttctcccc ttcataatca 2064901 gattgaaaat acgtttctgt tcctgaagct gaagcaaccc ctgaattcac atgaatgctg 2064961 acaaaaaggt cagcctgatt ggcacttgcc ttagccactc tttcctccaa ggtcagaaaa 2065021 tgatcgtcag accgggatgc aacaggattg gctccctcct cttttagttt gtctgtcaca 2065081 tgctctgaga cagccaaatt aatatccttt tcaaagagcc cgtttccgac cgctccactg 2065141 tcttcaccgc cgtgtccggc atcaatatac actgttttcc cttctatcgg ctctgctgcc 2065201 tgtgcacaag gcgcgagcgt caaagccaat ccgcacagcg ccaagctcct ccataacatt 2065261 ctcaacttac tccctccggt cacgagttct ttcgcagctg aatatcttcc agctgtaaag 2065321 ttccattatc cttctttgta tatttcacca ggacatgtgt ctgatctggc agtgattcac 2065381 attcatcacg tttatccttc ggaacttgta tcatggtttc ttctccatta agagaaaccg 2065441 caatcgtatg aggatcagcc gagccaatgt attttccctc ttcggtaaac ctcggcactg 2065501 agtcatccgc acttgcaaca ctgcaccccg aaagaaagag cgcagtaaac agcaaaagaa 2065561 ccgtttgttt cacatgacca cctcttcctg atgtttggct tttatctttg accagaatgg 2065621 agaatttgta aagacaacgc gaatgcaggc gagcaagttc catgattttc aaaagggcta 2065681 tacgacccga tcatttcctg ttgttagaaa gataacgagc agatttgtct atgaggatgg 2065741 ctctaattga ggcgccaatt agaaaaaatt agcggaaaga agcaactttt tattcatttt 2065801 aaaaaatttg agaatagggt gagcaaatcg tttgacgggt gggtcagcca agcgtaacct 2065861 tttaaaggat atttacttta ttgaaagaag ttaaagccat gaaaaaattc gttctgctgc 2065921 tggcggcagc tgtcatcaca tgctccatcg gccaccaaat cagtggcggc tacaaaggcc 2065981 ccgaaaaaga gcggccaaaa catcactctg cactcaagat attcagtcgg taaagcagat 2066041 caattgcatt aatttttaca tataggctag aatatgtgcg aatccaaacg aaagaagatg 2066101 atcaaatgaa tcctaagtat aagccacttt ttgaaccatt tacgtttaaa agcggcgtta 2066161 caatcaacaa ccggatcgca gtagcaccga tgactcatta cgcttctaat gaagacggta 2066221 caatatctga agcggagctc gactacatca tcccccgttc aaaagagatg ggaatggtga 2066281 ttacagcctg cgcaaatgtt acaccggacg gaaaagcatt ccccgggcag ccggccatcc 2066341 atgacgattc caacattcca ggtttaaaaa agttagcaca agccattcag gcacaaggcg 2066401 ctaaagctgt tgtacaaatt catcacggcg gtattgagtg cccgtctgag ctcgttcctc 2066461 aacaggatgt tgtggggcca agtgacgtgt ttgataacgg caaacaaatt gctcgcgcat 2066521 taacagaaga agaagtggaa aacattgtga aggcgtttgg agaagcgaca agacgcgcca 2066581 ttgaagccgg ctttgacggt gtcgaaattc acggtgcaaa cggctactta attcagcagt 2066641 tttattctcc gaaaaccaac cagcgcacgg atcgctgggg aggaagcgat gaaaaacgat 2066701 tagccttccc gctcgctatt gtcgatgaag tgaaaaaagc cgcttcagaa catgcgaagg 2066761 gtgcattctt agtcggctac cgcctgtctc cggaagaacc tgagacaccg ggattgacaa 2066821 tgactgaaac ttatacgctt gttgatgctt taggggataa agaattggat tatcttcata 2066881 tctcactgat ggacgtgaac tcaaaagcgc gccgcggtgc agatccgact cgcacacgca 2066941 tggacttatt gaatgaacgt gtcggaaaca aagtgccgct gatcgccgtc ggttccatcc 2067001 attccgctga tgacgcgctt gccgtcatcg aaaacggtat tccactggtc gctatgggac 2067061 gcgaaattct agttgaccct aactggacgg taaaagtaaa agaaggccgt gaaaagcaaa 2067121 tcgaaacagt gatcaaaggc acagataaag aaaaatatca tttgcctgaa ccgctatggc 2067181 aagcaattgt gaacacacaa ggctgggtgc cttataaaga ttaatgtgca aagactgccg 2067241 aaacgattcg gcagtctttt ttccctttat ataaatagtt tgtgtacaca tctaaacagc 2067301 aaaagaaaga gctccccacc aacttcgaaa agaaaatcca ggaaaaaccc ctcacgcttt 2067361 cttgcttttt tctttttcat tcgtacgtct cctttttaca tgaatacgcc ttacttacga 2067421 ttttgcagga gaaaggtttc attttataac ggacacatct agggtcgatc atgcttcgtg 2067481 atcctataag atgtatgaat ggaccaagag tgcaggtaat accgccattt gctttcctta 2067541 cttttcaaac ctatccttta ctatatgcgg atacttaata ttcttctccc atactacaaa 2067601 tgtccccaaa acaaaacgcc tcctatttat cagcgcaaac taataaataa aagacgtttg 2067661 atttaatgac cacttaataa gctcatgttt aagaagcctt atgctctaac ctcagcttat 2067721 ccgcaaccat tgcaatgaat tcactgttgg taggtttagc ttttgtcatg ctgacagtat 2067781 aaccaaacaa cgaggaaatg gaatcaatgt ttcctctgct ccatgccact tcaattgcat 2067841 ggcggatcgc tctttctaca cggcttgcgg ttgtgttaaa ttttttggcg atgtccggat 2067901 agaggacttt tgtaatgctg ccgagcaatt cgatgtcatt gtataccatt gagattgctt 2067961 cgcgcagata gagatagcct ttaatatggg ctgggacgcc gatttcatgg ataatgcttg 2068021 tgatgctcgc gtcgagattt ttcttctttg gttcaggctg gctgctgcgt ataatactgc 2068081 tttgcgatga tggcgcacga tgcgtcacac tgctggcatt tccgctgacc tggcggatat 2068141 ggccgacaag gttttccata tcaaacggtt tgagaataaa gtaggacgcg cctaaatcga 2068201 cggccttttt cgtgacatct tcctgcccaa aggctgtcag cataatgaca ttcggctgtt 2068261 ttttcagatc tgattccctc agcctctcta aaaccgcaag tccgtctaga tgcggcataa 2068321 taatatctaa tacgagcaca tcgggatctt tttctttaaa cagcgacagg cattcctgtc 2068381 cgttataagc aacgccgatc acttccatgt cttcctgtcc ttctatatat tcacttaaca 2068441 ggcttaccag ctctcgatta tcatcagcaa cacaaacttt aattttctcc acgtttcttc 2068501 ctccccaaat gtagttaaca ggattcaccc ttgctacatg tttacattcg acaaaaccgc 2068561 tatataccct ctaaaaaaat cataatcacc aatattagtg gcatatcttt gttattctat 2068621 gtttttctct gtttttcgac taaaaatgaa atttgacaaa caaggaaacg tgaatttgtc 2068681 gaaaaatctt cttttgtata ttttaccgta tgtattctga gaagtgaaga gggatcagga 2068741 tatactgatg aacgaatgga tgtgcacgaa aaaaataagc tgcgcttctc gcgcagctta 2068801 cccagttgtt ttgacttgat ccgcttgttt taaaagttct ttcgcatggc gtttcgttaa 2068861 gtcggttact tcgacacctg caatcatgcg cccgatttcc gctacctttt cctgcttaga 2068921 gagcggcttg acacgtgtcg tcgttctgcc gtcttttaac tccttcgcaa tataaagatg 2068981 cgtatcggcc atggcagcca cctgaggcag gtgtgtaatg cacagcactt gtgatcctat 2069041 tgacacctta tggatcttct cagcaattgc ctgtgcgacc ctgccgctta caccggtatc 2069101 aacctcgtca aaaatgatcg atgtcacatc ctgttgtgag gaaaaaatgc tttttatggc 2069161 aagcatcacc cgtgacagct ctccacctga agcgactttc gaaagggatt tcagcggctc 2069221 gcctgtattg gttgaaatta aaaacttcac caggtcaatc ccttgttcag tcagctgaac 2069281 gggctggccg tttacaagcg gcgcctcttc attgcgtgac gctgttctga ccttaaattc 2069341 cgtatcaaaa gttgattttt ccatgtacag gctttttaat tcccgatgaa tctcatcagc 2069401 cagctttttc gcccatgttt ttcggatttg tgacacattt gccgcttcca ctgcgacatc 2069461 tttgccgacg gagtcaagct cctttttcaa gctttgaagg tggctgtccc tgttttcaat 2069521 ttggtcaatc tcttcttcaa ttttagaagc atattccaaa atgtcttcaa cagtggcacc 2069581 gtattttcgt ttcagctgtt tgatttcatt aagtcgcgtc tcaatatagt tcaggcgttc 2069641 cggatcaaat tcaagctcat ccagcatatt tctcatctga aatgtggcat cctcaagcaa 2069701 atagtaggag ttcgaaacac tttcagacat ttttttcagc ggttcgttta tatcagatat 2069761 atcttcaagc tgcgctgatg ccattccaac ccagtccaat ccgccctgct cactgcgaag 2069821 cgcgttatat gcattttgca gcgactcata tatcttctca aagtttgaaa tttgctggcg 2069881 ctcttcttgg agctgttcat cttcgttaag ctcaagcttt gccgattcga tttcttcgag 2069941 ctgaaattga ataagatcaa gacgatgggc catttcctgt tcgctttcag aaagctgctt 2070001 aagctttttg agcagcttca cataccgctg gtacccttcc tgatacgttt tgagcgcgct 2070061 ttccacttcg gccccggcaa acttgtccaa aagctggaga tgattttcgt cttccattaa 2070121 cagctggtta tcgtgctgcc cgtgaatatc taataaaagc ctgccgatct ctcttagtga 2070181 agcaatcgtg acaagcttgc cattgacacg gcaaacgctt ttcccgctcg tgctgatatc 2070241 ccttctcatg acgatcattt cgtctgaaac gtcgattccc tgctcagcgc atacgcctaa 2070301 aacaggatgg ccgctctcca acagaaacag cccttcaagt tcggcttttg cttccccata 2070361 tctaacaaat tcagatgatc cgcggcctcc gactaaaaga gaaatggcat ctatgatgat 2070421 ggatttgccg gctccggttt ctcctgttaa aaccgtaagc ccgcgttcaa aagaaaccgt 2070481 cagttcctca ataatggcaa agtttttaat cgatagttca gctaacaaac agcattacac 2070541 ctcttatctt tgttagattt tctgttacag cagttcaagg agcctgtttt ttacgccttc 2070601 tgtatcttca ggagtccggc aaataattaa aatcgtatca tctccgcaaa tggtccccat 2070661 catttcatcc cagtccaaat tgtccatcag cgccccgatt gcctgggcat tgcccggcat 2070721 cgttttcagc acaatcatat ggcttgctga gtctattttc acaaatgcgt ccatcaatgc 2070781 ccgctttagc tttgacagcg gattgaaacg ctggtccgcc ggaagactgt atttgtaaga 2070841 accattattt gtaggcactt ttacaaggtg aagttcttta atatcccgtg ataccgtggc 2070901 ctgcgttact ttgtatccat cctgctttag catgtcgacc aattcatcct gcgtttcgat 2070961 ttcattgctt gtaatgatct ctctgatttt aatatgcctc tggcctttgt tcatgtaagc 2071021 acctctattt ccaagcttat ctgttctttt atgttatatg attctctgca cattgtacat 2071081 gaatgcagaa aaaaggaata atagcgccct attattccgg tacatctgct tttttttctt 2071141 ttaacgtctt atgtgcttct tctacaacgc gcatgatctc ttcttccggc agttcctggc 2071201 cttcctgtcc ctctcccggc caatgcaaat gaaggagaaa ctcaatattt ccgtctcctc 2071261 ccgtgattgg agaaaatgac aagcctttac agatatagcc ttcagcggca gaaaaactga 2071321 tcattcgctt gagcacatca gcatgcactt taggatctct aacaatccct tttttgccga 2071381 cggattcccg tcccgcttca aactgaggct taactaaagc catgcagtcg ctgcccggta 2071441 cgagcaaagt ccttaggaca ggcaggatga gccgcagtga aataaaggac acatcaattg 2071501 tggcaaactc cggcatgccc tttgtaaagt ctgccggtgt tgcataacga aagttcgtcc 2071561 gttccatcac gacgacccgt tcatcctgtc taagcttcca tgcaagctga ttatagccta 2071621 catccacagc gtatgactgt ttagctccat tttgcaaagc gcagtccgta aaaccgccgg 2071681 tggaggagcc aatatcaatc ataattttat ctttgacaga gacgggaaat tccttcaacg 2071741 ctttttcgag ctttaagccg cccctgctca catacctcag cgggtttcct ttgacagtta 2071801 acggaaggtc gcggtcaatt ttttctccag gcttgtccaa gcggttttcg tttgaataga 2071861 cgatccccgc cataatggct cttttggctt tttcacgcgt ttccgccagc cctctttcca 2071921 ctaataatac atctaatcgt tctttctttg acgtcatgat ccaattcctt tgtgtgtctt 2071981 tggtggcatc agtaatctaa tacgatttgc cacctgctgt tttgtcagtc caatttcctc 2072041 aagaagcgct gttacacttc cgtgttcaat aaaccgatca ggtataccca ttctgtcaat 2072101 cggagtatga tattcacctt gatcatgagc gaattctaaa atcgagcttc cgaaaccgcc 2072161 ttctaagacc gcttcttcaa ttgttaaaat tggcaagcct tcttttagga tactcttcat 2072221 catcttttca tcaatcggct taataaaacg cgcattcaca acgcgcacgg aaaggccttc 2072281 tttctgcagc tcttcggctg cttcaatcgc catttcgatt gttgtgccga atgttaagat 2072341 gacagcatcg ttccctggac gcagcacctc ccacgtaccg atcggaatcg ttttcaactg 2072401 ttcatccatt tttacgccga gtccgtttcc gcgcggaaaa cgcattgcta tcgggccttc 2072461 gtcatagcta agtgctgtat gaaccatgtg ctggccttca ttttcgtctt tcggcatcat 2072521 taagaccatg tttggaatgt ggcgcataaa cgcaatatca aacacgcctt gatgtgtctc 2072581 tccatcagcg ccaacgagtc cagcacggtc aattccaata aacacattag cgttttggcg 2072641 gcagatgtca tgaacaactt ggtcatatgc cctttgcagg aaggttgagt aaatcgccaa 2072701 aaacggcttc ataccctgca ttgccatagc tgcagccatt gttgcggcat gctgttctgc 2072761 gattcctacg tcgaacatcc ggtcagggaa ttcctttgcg aagccttcaa gctttgaacc 2072821 gacaggcata gccggcgtaa tggctacaat gcgtccgtcc tcgcgcgcca ttcgctgcac 2072881 agttccgctg acaagaccgc tccacgaagg agctgcggct ttcggcttta caaagtcacc 2072941 ggtattaatt ttatatggtc cggtaccatg ccatgtccca atcgtatcgg tctcagccgg 2073001 tttgtacccc ttcccttttt tcgtaatgac gtgcagaaga acagggcctt tcgttttttt 2073061 ggcgtattga agattctcaa tcagctcatg ataagaatgt ccgtccactg ggcccaaata 2073121 cgtaaaaccg agctcctcga aaaacattcc ggagacgagc atgtatttca ggctgtcttt 2073181 gacccgttcc gccgtggcgg caagcttgcc cccaactgcc ggaatctttt taaataagta 2073241 ttcaagctca tctttgaccc actggtattt ccccgcagtg cggagccgtc cgagcataga 2073301 gtgaatggca ccgacgtttg gcgcaatact catttcatta tcattaagga tgacaatcat 2073361 gtcttttttc tcgtcgccga tgtggttaag ggcttcgagc gccataccgc cggtcagcgc 2073421 gccgtcacca atgatcggaa taatatattc atccgttcct ttaatatcac gggcagctgc 2073481 cattcccatc gcgcctgaca gagaagtcga gctgtgcccg gtttcccaaa catcgtgctc 2073541 gctttcactc cgctttggaa atccgcaaag ccctttgtac tggcgaagcg tcgcaaattc 2073601 ttttccgcgt cctgtcagca gcttatggac atacgactga tggcctacat cccataaaaa 2073661 tttgtctttc gggctgttaa attccttatg cagggcaaca gtaagctcta cgacacctaa 2073721 gtttgggccg atgtggccgc cggaagcgga taaacttgta attaaaaact gacggatttc 2073781 atcacttaat ttctctaatt catcaatgga catgtttttt aaaaacgacg ggtcctgtat 2073841 tgataaaaga tccaaagcgg atcaactcac tttcagcatg aatttctgca atgatacatg 2073901 tcttttgcat gccgagctga caataatctc agacataaaa aaagacaaac gcgcttttcc 2073961 ttttcatttt tcatataaac tgcttacatt ttaccatacc tcgtgcagcc gcttcaaatt 2074021 aggatcgttt tagtgatctc ttgccgcaat taaatcacaa agctcatata aaaggtcttt 2074081 ttgaagagag agtccgccga tcaatcgctt cgcctctttt atatgaacat ccaatttatg 2074141 tttggcccct tccaatgaaa gaagcgacgg gtatgtcgat ttgtcatttg tggtatccga 2074201 gccgacacgt ttgccgattt tctcttcact gccttctaaa tctaaaatat cgtctctgat 2074261 ttgaaatccg attccaatgt ggctgctgaa ggtacgcagt gtttcaatgt cttcctcagg 2074321 cgcatcagcc aaaatagcac cggcgattac acaaaagcca aggagcttgg cagttttccg 2074381 ttcatgaatg gattcgagct cttcaagcgt gacttgtcgg ttttccgctt ccatatcagc 2074441 tacttgccca ccgaccatgc cttcggtgcc tgccgctgaa atcagttcat tcacaagccg 2074501 caggcgcttt tctgctgaca cctcgtctga cacgtgggag gtaatcagct taaagctttc 2074561 tgtgagcagc ccgtcacccg ctaatactgc cgtcgcttca ccaaacactt tatggtttgt 2074621 cggcttcccg cggcgcaaat cgtcatcatc catgcatgga agatcatcat gaattaacga 2074681 atacgtgtga atcatttcga cagcacagcc caccggaatg ccgtcttttt cgctttttcc 2074741 atatgcattt aaaacagcca gtacaatcag aggccgcaac cgctttccgc cggcctgtag 2074801 agaatatagc atagatttct ttaatgagtc cggcatatca agcttttctg tatagacaga 2074861 aagctgattt tcaattgttt ttttccggtc cgccagaaag ctcgttaatt tatttgtcac 2074921 cttcgtcttc ctcctgaaca ctgaaaggtg ccagttcgcc gtcttctttt aaaatgaagt 2074981 ccatttgctt ttcgactttt tgcagctttt catggcacat ttttgacaga gccatgcctt 2075041 cttggaaata gttaatggct tgctctagag gcacatctcc ctcttcaagc tttgatacaa 2075101 tgctctcaag ccctttcatc gcttcttcaa atgtcatgtt ttcatttttt ttcacgtctg 2075161 tcatttttct tcccctctct tttctaatac ttcacaggtc agcacgccat ccttcagctt 2075221 gatttcaagc cggtcctgct cttctatttg actgacactt ttaatgagtt tatcttcttt 2075281 ataagccaag ctgtatcctc tttccatcac ttgaagagga cttagtgcat tcagcttgcc 2075341 aagaacggtt tgaaattggg aatgcagctg cttcatttgg atattcatat tttttctcag 2075401 ctgatttgtt tgttcctggt atcgtgttct cgcttgtttc agctgttcat gaggatgcaa 2075461 tgcctctaat ctgtacgttt cacgctccag ctgtctgctt ttccgatcta aaagagcggt 2075521 cagctgtgct tgaaactgct ggtacgcgag gtcaaactgc tgctcttttt gcgcatacaa 2075581 acgctttgga aaacgaaagg cataggacga ttgcagcgtt tgtatccgtt cttttttctg 2075641 gccgagatgc tgctgcattg ctcttgtcat tctgacttcc gctgtttttg tccgttcgat 2075701 taaatcagtg gtatgaggca cagcaatctc agctgctcct gtcggcgtcg cagctctgat 2075761 atcggcgaca aaatcactaa tcgtaaaatc cgtctcatgt ccgactgccg atataatcgg 2075821 aatattggaa gcaaagatgg cgcgtgctac aatttcttca ttgaatgccc acagttcttc 2075881 tatcgaaccg ccgcctctcc cgacaattaa tacgtcgcaa atctcttttt catttgcctc 2075941 ttcaatgcgc gtaacgatgg atctgctcgc attttcacct tgtacgagcg ctggaagaac 2076001 aatgactttt acaaggggat atcttctttt tagagttgta ataacgtctc tgacagcggc 2076061 acccgttgga gatgtcacaa ccccgattgt ggctggaaat gcggggattt gttttttgta 2076121 gcggtcgtca aataaacctt ctccggcaag cttctttttt aattcttcgt acgctaaata 2076181 aagcgctcca accccgtcag gctgcatttc tttggcatat aattgatagt ttccgctcgg 2076241 ttcatatacg gaaattccgc ctctgaccag cactttcatt ccgttttcag gtttaaaagg 2076301 cagacgctcg ctttgtctcg cgaacatcac cgactgcatt cttgcgtttt cgtcttttaa 2076361 agtgaaataa atatgccctc gtgtgtgtat ctttacattc gacaattcgc ctttaatcca 2076421 aatattttca aggtgaggat ctacatcgaa ttttcgtttt atatactttg tcagcgctga 2076481 gacggtcaca tacgctgctt cacccatgtc taaaaactcc tctcctaagc attcctgcac 2076541 cataactaaa gaaaacccgc cctggcttta ggagcctgaa gaagcgggta tcgtgctcat 2076601 attcaaggcg ggtaaacatt tcgcctgtga atatctccaa ttatctatga taacgtacgt 2076661 ttcgcagatt taacagtatt atgcgcaagc atcgtgatgg tcatcggacc tactccgccc 2076721 ggaaccggcg ttatgaagga cgctttttcc tttgcccctt caaattcaac gtctccgcaa 2076781 agctttccgt tttccagacg gttaacgccg acgtcaatga caacagcgcc ctctttgatc 2076841 tggtctgcac tgatgaagtt ggctctgccg actgccacca ccaggatgtc cgcttttttc 2076901 gtatgttcag taatattttc tgttcttgaa tgacagtaag taaccgtcgc gttttcattt 2076961 aataaaagct ggccgacagg tttgccgaca atgttgcttc ggccgactac aacaacctct 2077021 ttaccggaaa ggtcaatatt ggttttcttc aaaagctcaa caattccatg aggcgtgcaa 2077081 ggaagaaacg tatcttcgcc aagcagcatt ttccctacgt ttaacggatg aaaaccgtct 2077141 acatctttat caggggagat acgttcgatc accgcttttt cagaaatatg gtctgggagc 2077201 ggaagctgaa cgagaatgcc atgaaactca gggtcttggt tatattgatc aataatggaa 2077261 agcagttcag cttctgtgag gctgctgtca aattgatcga gcttgaaatt cattcccatt 2077321 gtttctgccg cttttttctt tcctcgcacg taagagtgag aagcaggatc atctccaatc 2077381 aaaataaccg ccagtccggg agtgacgcct tgctttttaa gctcttctac ctcttttgcc 2077441 aattgttcgc gtttttctct agccgtttct tttccgtcga tgattgttgc agtcattttc 2077501 tttcctccta tgattgttca atatcagatt taatgttaga aagaaccccg tttacaaact 2077561 ttgtcgcttt gtcatcacca aaccgttttg ccagctcaat cgcttcgttc atggagacat 2077621 tcaccggaat gtcttcggca tatgccattt catatgctgc caggcgcaaa atcgcacggt 2077681 caacattggc aatccgatcg agcttccaat tcaccagatg cttggagatc atttcatcca 2077741 gctggtcttg gtgttccaat accccgtgta caagctgttc aaagaaagga tctgtttttt 2077801 cttcatccag tgcgtgttct atggcttcat tcactgcaat atcgctgaca tcaatttgaa 2077861 atagtgcctg caaagctttt tctcttgctg ttcttctttt cattttcttt ctcctttgat 2077921 cctctttatc cgcttgtcgt taagccacaa agagatcata acatattttt ttcgtatccg 2077981 catattgaaa tcaaggtttt tttaccctat taccgaatat tttcacacac cttaatatga 2078041 ttattcggat ttcacgttca tgaagaaact cggctatgta agccggcttt cttcatgctt 2078101 tgaaataaag ggtaacgtgt aaaaaaacca aagggccgcc ctccccttgg tttcgtgtta 2078161 agccatttac atttcttcgt cgatttggac ttcttgggct tttgtgtcaa attgaatgcc 2078221 gacgatgtga atattgatct cgttaatcga aagagacgtc atatttaata aggtttgacg 2078281 aatgttttcc tgaacggatg ctgcaacttt cggaatcgaa acgccaaatg taacgacaca 2078341 gtatacatcg atcgtaattc cgtcatccgc caggtcgact ttgacacctt tgccatgatt 2078401 cactttgcca aagcgctcaa cgacgcctgt cgcaaagttt ccgcgcattt cggcaactcc 2078461 atcaacttct gatgctgcaa tgccggcaat gacctcaatg acctccggtg caatctcaac 2078521 cttacccaaa tgcgtatctt cgtgatccat tttaagcaag ctgttgtctt tcattcaatt 2078581 cacctccgta aaaattatga gcccattaca tcatatgttt ctaaaaattt cgtattaaac 2078641 tctccgctca caaatgtttc gtgttcaagc agttttaaat ggaaagggat tgttgtctca 2078701 atgccttcga tgacgaattc gctcaatgcg cgcttcatgc gggcaatcgc ttcatctctc 2078761 gtttttccgt atgtgattac ctttgcaatc atgctgtcat agtacggtgg gatggaatag 2078821 ccagggtacg cagctgaatc gacacggaca ccaagaccgc caggaggcag gtacatttta 2078881 atttcaccag gtgacggcat gaaatttttg cttgggtttt ctgcgttgat tcggcattcg 2078941 atggcccagc cttcaaattc aacatcttct tgcttgaggc tcagttccat tcctgaagcc 2079001 actttgattt gttccttgat caggtcagtt cccgtcacca tttctgtgac tgggtgctcc 2079061 acctggattc tcgtgttcat ttccatgaag taatagcgct gttcattgta gtcatagata 2079121 aattcaactg ttccagcacc tgtatagcca accgctttgg cagcctttac cgctgcatct 2079181 cccatttgct ccctgatttc tgaatcaagg gcaggagatg gtgattcttc caaaagcttt 2079241 tgcaggcgtc tttggatcga gcagtcgcgt tcgcccaaat ggatcgtatt tccgtagtta 2079301 tcagcaagca cttggatctc aacgtggcga aaatcttcta tgtatttttc gatgtataca 2079361 cctggattcc caaatgcagt tgccgcttcc tgctgtgtaa tcttaatgcc attaatcagt 2079421 tcctcttcag tgcgggcaac cctaattcct tttccgcctc cgcctgcggt ggcttttata 2079481 attacaggat acccaatttc attagcaagc gaaaccgctt cttccacatt ttctataatt 2079541 ccctgtgaac ccggtacgat tggcacgccg gcctgtttca tcgtttcccg cgcaacgtct 2079601 tttgttccca tttttgaaat ggcgtcagcg ctcgggccga caaacgtgac attcacttct 2079661 tcacataatt cagcgaaatc agcattttca gctaaaaatc cgtatcccgg atgaatggcg 2079721 tccgtgccag tcagctttgc aacactcaca atatttgtaa cgtttaaata gctgtctttt 2079781 gatgctttcg gtccgataca aaaagcttca tcggccattt gaacatgaag ggcatcttta 2079841 tcagcttctg aataaacagc gacagtctca attccgagct ctctgcaggc tctgatgatt 2079901 ctgacagcaa tttctcctct gttggcgatc aatagctttt taatcatgtt cagtctcctt 2079961 actccgcttt tacaagaaat agaggttgtc cgtattcgac cagctggccg ttttctacta 2080021 atacttcaac gatttcgcct ttcacttctg cttcgatttc gttgaaaagc ttcatcgctt 2080081 ctacaatgca gacaactgtg ttttcattta cttttgaacc ggctgttaca tacgggccag 2080141 cttccggtga tgaagaagca taaaatgttc ctaccattgg tgaagtgatt ttatgcagat 2080201 tctcatcttg ctttggtgct tcttgggcag gtgccgctgc ttgctgcgct tgcggctgaa 2080261 ctgcctgcgg agcctgtgct tgtacaggtg ctgccggtgc ctgctgcatg acttgaaccg 2080321 tgcctgcttc gtgttttttc agttttaagg atacaccttc attttcatat acgaattcgt 2080381 caattgtaga ctcgtcaatt gctttaatca gctcgtggat ttctttgata tttaacattc 2080441 aatcgcactc ctatgtatga aatttctttt tttataggtt actactaaaa gtacatacta 2080501 tgttcatctt acaggagcgg acttttgaat tcaactctaa tatgacagca acgcaaaaag 2080561 cccgcttgtt tagcgggctt ttttccctca ttcttattta gagggttcaa atgtgacagc 2080621 gacatctttc attgttttga tttcttttgc cacaaggtct ataatggctg tcgccttcga 2080681 tttagagtgt ttgtctgatt tgactgtaat attgatttta tctccttcag cattaacaag 2080741 cgcatcctcg taaccttgtg ttttaatcag cgtttccagc tgtttttctg ttccttccac 2080801 ttcactgaga gccgtcattt tatcgtatgc ttcgcttttc tccttggctg ttgcatcatc 2080861 gcttgacaca atggcattca gctcttctct ttctttgctt ctggcatctt ctaaatcaag 2080921 acggtacgtt gtaaacaaat catcatcggc tgtttccgta acaacagttc ctttttcact 2080981 ggcttcagcg gatgtttcct tgtctgctga tgaatctttc gttccctttg ttccatcttc 2081041 ttttcctttt tcagtttctg taccgctttt ttccttcgtg tcttgcttgg caggcgcttt 2081101 ttcagttgcg acctctccgc tgtcagacgc gcttttttca ctttgcatct gcacggcgtt 2081161 tttgctttcc ggcgacatga tatagtagac gcttaacacc acgacaagac tgagcattgt 2081221 taatagccaa acggtttgtt ttttaagcat ttatgaatcc tcctttattt ttttaggggc 2081281 aaccgcaacc cggtggcttg gaacatccag gacccgtgtc accgcttcga taatggtttg 2081341 ttttatttga acgttgtcca ctccttgagc aacaacgagt acaccgcgta tatcaggttt 2081401 tttcgtttgg acgacgacag gtgtttcttt atcgccgttt ttgatcatga cgatttcttc 2081461 ctccgatgat tggtctgtaa cgcttctttt tccgccttct ttgtcagttt cttcagtggt 2081521 tgtatttttg tttgatttgt ttttttcgta tactttcagc gacgttgcat ctacattcac 2081581 gacaaccgag acatcgtcca caccaatgat tgtttcaaga atttctttca gttgattttc 2081641 gtattctttt tcatagtcat cgatcgagtc tttaggttta tcagattttg aggctttaaa 2081701 cacttcggct gttttctctt tgctgtctgc ggaatgttgt gatgatacgg ccgttatcgt 2081761 tttggcgttt tcagttttct caggtgaaga aaacagctgg ctgacaagca taaaggaaac 2081821 tccgagaaca aaaacgaata gaaagtaatg atatttggtc agcttcggct tttcgccgtc 2081881 cttcgtttgt cccggaagaa actgcttttt caatacattc cataatccgt ttttattcat 2081941 tgccgacact ctccccgcct tccatatgaa ccgtaatttt ctcacttccg atttcccaaa 2082001 tgtccgcgag ctgcgtttgt atctgtttgg cttctttttg ttcggctgct tcttttgtta 2082061 cgtatgcatg atctgtatca atgtggaccg gcgcgaccgt ttggaccgtt ttttcagaag 2082121 acggggccat atacacgctg attgttttaa tatcctcttc tgaatctacc ttttctcctg 2082181 ccgtgagttt gatgcggcct actttatatt catcatgact gaatctctcc tccgctttct 2082241 tttttagttg gacagccatt tcttctagaa tatatgcgcg ctgggaagct tgtatttcta 2082301 ttttttttga attgatttga ttttttatgt cggcagactc tgactgcccg ttttttgtga 2082361 ggtattcaaa gatgacttcg gggtctgtct tgaaaagttt aaaaatcggc gtaagcatga 2082421 cgacaatcaa gagcaggctg actaccattt ttgcgtactt ttgcatgctg gagctcggca 2082481 gcagcatatc aatcacaatt gcaaatagga taaacaacac gatggtggta agccattccg 2082541 ttaaaaaact catttgcctg cctccttcat ttcatcatca tcgtgaggtt tccggctgtg 2082601 attatgacag taaggcttaa aaaaaacatg agagacacaa tggcgagagc tgcaaaaata 2082661 taaatgacgc ttttgctgat gacgtcgagg caggtgatga cgggcccgcc tcctagcggc 2082721 tgaagaatcg cggctgccag cttataaata aaagcgaggg aaagcacttt gattgccgga 2082781 aatgccgcaa tacagatcaa aatagcgaca ccgagaatcc ctaccgtatt tttcagcagt 2082841 aaagaggcgc tgattactgt atctgttgcg tctgtaaaca ttcggccaag cacaggaata 2082901 aaatttccgg ttataaattt agccgtcctg agcgtaatgc cgtctgtcac tgcagctgac 2082961 gctccctgaa cagagatgac gccgagaaag atggtaagaa aaacagccag tgctccgatg 2083021 gcgatatttc tgagcaggtt agccagctgc gttactttgt attgttcagt catcgtgctg 2083081 acaatgctca gaatcgctga taaaaaaatc agcggcatga cgatattctg aatcaagaga 2083141 ccgctcgtgt tcatcaggaa gaggataaca ggatgaaaga aggcagcaga tacagctccg 2083201 cctgaggaag ccaaaagcgc caagaggagc ggaatgagcg ccaggataaa gctggtcatc 2083261 gtctgaatcg cctcagttgc atagttaatt gccacatgaa agctattaag cgcaaggata 2083321 atcagcacca tgtacacaat tgagtaagcg accttactga cggtgctttg ctgaaaagca 2083381 ttttgcaaaa gctgcagaat gacgcaaaaa atcgtgagca aaatcaatgt gcccagcagc 2083441 tttccgttgg caagcacttc atgaaacaaa taagaaaaga gagctttcag ccattcttgc 2083501 ggtgagaatg atttatcgcc attgataaac tccattaagc tgcctttttg gctttccggc 2083561 agcagtccgc cgtattctgt cataatgtca ttccaaaatt ccccgatctt atctgtttca 2083621 agcgaggctg ctgtcctttc cgctaattgc tcggctgttt cagcatggtc ttccgtttgt 2083681 tctgcattac cagctgcttg tacaatttct gcacggcctg ctatgatcag cacggccaaa 2083741 agcaaaaccc attgaaagcg cttcaatcta ccgcctcctt tcggttatga catagaaggt 2083801 ataagtccga gaatcgtttc gataatgacg gttaaaatag gcacagccat tacgagtatt 2083861 aaaattttcc ccgccaattc tattttcgag gcgatggctc cttgaccggc atcttttgtg 2083921 agctgtgccc cgaattcagc aatataggcg attccgataa tctttaaaat ggtttcaaca 2083981 tagaccatgt tgacatttgc attaatcgca attttttcta tcattcgaat aatgtcgtag 2084041 atttggtcta ccaaataaag aaaaatggca catccggcaa aaacgacgat taaaaacgca 2084101 aaagtcggct tttgttcttt tacaattaaa gaaaggaagg tggcgatcag ccctaaacct 2084161 acaatttgaa caatgtcaat ctgcaagccc ccctatcctt ggaataaaaa cacagctttt 2084221 atctttttaa ataggtcatc tacaatcgtg gcgaccataa ataaaatata gataaaacct 2084281 aacagcgtca cccactgagc atattctttc ttgcccatct gatccaatat cgtgtgtaaa 2084341 aaagcgacca cgattcccac tccggcgatt tgaaatatga cattcacgtc tactcccatt 2084401 ttatttttgc tcccctcacg tttacatcaa tagaagaatg agtaacaagc ccgctaaaaa 2084461 gcccaaactt tttatcatct tttcgttttt cgcttgcgcc tgctcagcat ccgcttctga 2084521 ggcttccaaa tgtgtcagcg ccagcttgat gtgcttttgc tgagagattc gatcatgaat 2084581 cccaagcgtc tcgccaaact gcttcagcac ttcgtattcg ctttttttca aagacagggt 2084641 gtcccatacc ttctttaagc tttgctccca cgccgttttc gcggaatcac ttcccttgtc 2084701 cagctgatca ctgaatgcgg aaaaaagagt tgaaacaggc tgtgcgagct gtttggcaat 2084761 ctgctgtgaa gcagtatgaa gcggtgtatg gccgtacatg atttcagcct cgagggattg 2084821 aagcgccgca cgcagctggc ggatttgccg cggccgttct gtataaatct tcgccatctc 2084881 aaaacctgtc catgttgtcg ctaccacaat gaatacagcg cccagcagct tcagcatgtt 2084941 ttcacgcccg tcgtcctaga cagcacattt ccgtctttgt cataaatttg gctcactgtg 2085001 cccggccctt ttgctcttga taattccaaa tagcggtcaa aggctctttc ttcccacaaa 2085061 cgcttcaatg aaggccgctt catcaggtcg gatatactcc agccatgcgc cgatacgatt 2085121 actgaaacac cggcatgcag cgcctccaga agtgcatctg tatcttccat acgcccgatt 2085181 tcatcgacaa tcatcacctc agggctcatg gatcgaatca tcatcatcag cccttcagct 2085241 tttggacagg cgtctaacac gtcaattctc tgaccaaatt gatgctgcgg aataccgcga 2085301 agacatccgg caatctctga ccgttcatcg acgatccctg tctttacggg cagcatgttt 2085361 tttttgccgg tgcttgagag cctcgcaagg tcccggagaa gtgttgtttt gccggtttgg 2085421 ggcggtccga taatcagcgt attcagccag ctgttttgat ataagtatgg aagcagcggc 2085481 tccgcaatcc ccagcttttg ccgggcaatt cgtatattaa aagatgcgat gtcacggagg 2085541 cctttcacac ctccgttttc cgtaatgact ctgcccgcca gtccgactct gtggccgcct 2085601 ctgatcgtga catacccttt cttcagctct tcttcaagtg tatacatact atagttgctg 2085661 agccggctca ggatcagatg ggcatcctcg gccgtgcccg cataggacaa ataaacaggt 2085721 tgtcctcttc gaatcaattc aacagggcgg ttgatccgaa ttctgacttc ttcgatttcc 2085781 agccattgtt gttccggtat ttcagaaagg gcgtttttca tggattcagg gagaacctca 2085841 gcgatttcat tcaacagagc ctcctccttt ctaccgattg gcttctttaa aatgtatgat 2085901 gtgaggcaga ctttatgaca agcctctctt tatttatgaa cacccgccaa aatcaagaca 2085961 acacccgtaa aaatcagaat cagctttgca tacgaaagct gcccggcaat ttggtagatt 2086021 ccgacagtca ttgtaatgat aaaaatcaac ggaccgacaa tagcgagaat gctgttaacc 2086081 acaaccgcct tccggacatc gttggtcaca agcatgacaa ttgctgccgt cagctcaatc 2086141 atagaggata aaactcgtaa tcccgccatt gttaaaacag tagaattgat atttccaagt 2086201 aaaaatttca tagcactctc ccaacctccc atttttttat atgatatgct ctagcttgct 2086261 gaagtagtct tgtcattttc gtataaaaga aagattctgt ttttgggcac aaaaaaagcc 2086321 tgctcccatt tgggaacaga cttctttttt tctttctatg ctcttgaaac gtaagaaccg 2086381 tctgatgtat tgacaacaag tgtgtcgcct tcattcacaa agaacggcac gtttacaaca 2086441 agcccggttt cagttttcgc aggttttgta ccgcctgacg ctgtatcacc tttaatacca 2086501 ggttcagttt caacaacttt cagctcaact gtgtttggaa gttcgatacc aagtgtttca 2086561 tcctggtaca tcatgatatg cacagacatg ttttctagca ggtattttaa ttcttcttcg 2086621 atttgagttg cgctcagttc aagctgctca taagaagaag tatccataaa tacgtgctga 2086681 tctccgtttg catatagata ttgcattgtt ttggtttcga tttgcgcttt cgctactttt 2086741 tcaccagcgc ggaatgtttt ttcctgaatc gcgccagtgc gaaggttgcg gagtttagag 2086801 cggacaaatg ccgcaccttt tccaggtttt acgtgctgga agtcaacgac gcgccaaatg 2086861 ccgccatcta cttcaattgt taatcctgta cggaaatcgt taactgaaat catgtttaat 2086921 gtcctcctat attccaatca caaaataata agttcttttg gggaatgggt gattgtccgg 2086981 ttgccgtttt ctgtaatcac gatgtcatct tcaatgcgga caccgcctgt ttctggtatg 2087041 taaatgcccg gctccactgt gaccaccata cccggttcaa ggatagctga agatctgacg 2087101 gataatcccg gcgattcatg aacttccatg ccgagcccgt gcccggttga atggccgaaa 2087161 tagtcaccgt agccttttgc agcaatatga tcccttgtga gggcgtcagc ctcttttcct 2087221 gtcattcccg gcttaatatg tgcgacgcca agcgcctgag catcaaatac aacctgatag 2087281 atctccttca attgatcact gggctgacct acagcgaccg tccgggtaat atcagaacaa 2087341 tatcctttat aataagcgcc aaaatcaagc gtaacaaggt ctccgctttc aatcagtttg 2087401 tcactggcca caccgtgcgg aaggcttgaa cgaaggcctg aggcgacaat catatcaaaa 2087461 gaagagctgt ctgctccctg gcttctcata taaaactcca gctcattggc aacagcgatt 2087521 tcagaaatgc cgggtttcat aaacgtcaag atatgtctga aggcatcatc tgcaatcttc 2087581 gcagcttcct ctaatatctt aatctcttca ctagacttaa tcaagcgcaa cttttccacg 2087641 gattcagcca caggcactaa ttcggcatca ctgataacgg cgctgtatga agcgtaagtg 2087701 ccatatgtca tgctgttctg ttcaaagccg agacgcttga tgccaaacga ttcaacagtg 2087761 tcggcagtgg tctgaatcaa gctgccgcca tgttcaatga tctcaaaacc ctttacctga 2087821 accttcgcct gctcagtata acgaaaatcc gtaataaacg ctgctttgtc acccgatata 2087881 acagccaaac ccgccgaacc tgtaaaccct gtcatatagc gtacattagt gttgcttgta 2087941 atcagcatgc cgtcaattcc cagctgtcca aacaggtttc ttaatttctc tagcttcatc 2088001 ttgattctcc cccttgctgg cttaataagt agcgaacagc aagcttgtag ccttcagctc 2088061 caagaccgac aatctgccct ttcgcaacag gagcgataac cgactgatgc ctgaattctt 2088121 ccctggcgta taagtttgat aaatgcacct ctaccacagg aagactgatg cttgaaacag 2088181 catccctgat cgcatagctg taatgactca gggcgccggg gttcagaaca atcccgctgt 2088241 attgctcctc agcctcatgt atcgcatcta tcaaatcacc ttcgtgatta gactggaaga 2088301 aagtgagctg gatatgtaag gcttcagcaa actgaaaaag atctgtttca atatcggtca 2088361 gtgtctggcg gccgaatact tcaggctcac gactcccaag ccggttaaca ttcggtccgt 2088421 tcaaaatcaa aaaatgaggc acacaatctc tccttttcgc gagggtttct catgtaaaaa 2088481 atgttcactt ctcgtgaaca ttttatcata ctggaaaagg attatacact attctctatg 2088541 cattcccagc gcacgtgcaa gcttttccga attcagctca ttgtattcaa atgaaataga 2088601 atacccgaca aacagcccgt aaagcaaata aatgcaaatg gtcgtaataa ttgtatctga 2088661 tgtcagttcg gtcaccgtgc gcacatctgg aaaaatcgga ttaaaaacaa aaaacacgag 2088721 cagccaaagc accaagccgt ataaaatacc cggccacatt gtttttaaac gtttcaatag 2088781 aagaaaataa agaaatgctg cgccaattga aattactcca atcaaaatga tgctgattac 2088841 cgttcccagc ccatgttttt tccactctcc gagtacaaac ggctgcaata tcatattcgg 2088901 gctgatttcg gaaaaatgaa acaaatatgc gatataagca acgaaactcc aaagtacgcc 2088961 tccgcaaaaa cctgttgccg ccaccctgcc ggccattgaa acaggcggct tttgcttctc 2089021 attcaattct tcattttgtt ctgtatcttt ttcgcttgtc atcatggcac ctccagttaa 2089081 agtgtgccca aaaaatgaaa tgtcaataaa aaagctcaca ctttttggca gctgcgagta 2089141 aaatttgaaa ataacgggta taatgcatgt agaaaaagca aggctatggc aattttttca 2089201 gcctgtcaat ctagaggttt agcgctgttt cctgtacaat agagtgaaag gaaatggtta 2089261 gcaatcctaa agaaataggc aggttgataa tatgtcaaaa cataaagttc cgcccgctta 2089321 cggcgggcag gctgttgtgg aaggcgttat gtttggcgga aagcatcatt acgttacagc 2089381 catcagaaga acggatggaa gcattgactt ttttaagctt ccacgcaaac acaacccgaa 2089441 actgaacatc gtgaaaaaga taccgttttt acgggggatc gcggccatta tcgaagcgag 2089501 tgcaaacggc acaaagcatt tgaatttttc aagcgaacgt tacgggctcg atccatctga 2089561 agacgagaca cttgagcagg aagaaaaaaa atcctctggg ctgtctatgt atctcagcct 2089621 cgcagttata ggcgtcctat catttttgtt cagtaaattc gtatttacat tggttccagt 2089681 tttcttagcg gaactgacaa ggccgatttt ttccttgaac acagcgcaaa tcgcgattga 2089741 aagcctgttt aagttgattt tgctgctcgg ttacatctat tttttgtcca tgacaccgct 2089801 tattaaaaga gtgtttcaat atcatggagc cgaacataaa gtcataaact gttatgaaca 2089861 gaatttgcca attactgtgg agaatgtcca aaaccaatct cggcttcatt accgctgcgg 2089921 atcaagcttt attttattta cgattattgt cggcatgttt gtttatttac tcgttccgac 2089981 agatccgctt tggctgcgtg ttatagatcg tgtcgcactg ataccggtcg tgcttggtat 2090041 atcctttgaa gttctgcagc tgacaaacaa agtgcgtgac attcccggtc tgaaattact 2090101 tgggtacccg ggactttggc ttcagctgtt aaccacaaag gaacctaagg atgaacaggt 2090161 tgaagttgcc atcgaaagct ttaacgaact tctcagactc gaagcattgt ctgagcaaaa 2090221 tcagaagcct tctcacaacg tcatctaaaa tccgttgccc tgctattact ttcggaggtg 2090281 gacagttatg aatcatcgtg tacaacctat tattgctgta ttaattgcgc tgggagcgtt 2090341 cggtttcctc tatgtgctgg taaccaatcc cggagaaatg gcaaaaatgg cggtaaccgt 2090401 catcgtggca ggtatcatta tttattttat tgtgaaatat gtaatgaatc gaaatgcggg 2090461 cagcgaagga gcagccttca aaaaagcggc gaaacaatca cggcgccgga tgaaagaaca 2090521 aaaagcaaaa caccgcgccg gacataaggg acgtgtcagc cacctgcgaa gcgttccgag 2090581 cgccagcaag cctaagccga tgattctcaa gaaaaaaagc cagactcagc tgactgttat 2090641 agaagggaaa aaaaataaaa agaaaaacag agcgcttttt taataggtcc actgctttaa 2090701 aaacagctct gtccgtcttt tacctagctc aatcagggct agtttttttt gttgtgttaa 2090761 atgaaaatca gtggccatta cgtcatcaac agggagaaaa atgatatttt gttcatagcg 2090821 tgacgcaatg tgccttgcgt catgagcatc cttcatcgtt tcaaacaggg cgccgaacag 2090881 ttcaaaagcg ttgcggatat tttttttcgg acgctctctt tcacgcggcg caagcgtgac 2090941 accgatcaca gggcgctttc tttcctttga aaacagccag attggaaaat tgcttaacac 2091001 gcctccgtcg acaaccgtgg cggtgcctgt gtccgttttt aattttatcg gttcaaagaa 2091061 atacggaatg ctgcagctca ttctgaccgc tctggcaacc gggaacatat ctggatttaa 2091121 cccgtaacgg gccaaatcgt ccggcaaaac aatcatggtg ccgtttgtca gatcagaagc 2091181 aataaggcgc agagaccctt tctgcaaatc gccgaaaacc cttatgcctt tcgctcttaa 2091241 cagatcagca atccattttt ctatcgtatc gcctttgtat aagccaagac gccagtagat 2091301 ggacacccac tggagcatct ttaaggggag aaatgagtac ctctgatcca gcaatttctc 2091361 tccgtccact tcttcaatta aagcgtggat ttccttactg gtgtaacctg acgcaatgaa 2091421 agcggcaata atggcgccgg cgcttgtacc cgcaactctt ttaaagcgga agcctttttc 2091481 ctcaagcact tcataagcgc ctgcgagcgc aatgcctttt actcctccgc cggaaaacac 2091541 accgtcaata tacatctcat tccctccccc tccatccgat cgtttattac cattttaaga 2091601 aaacacgcga agaaatagac caacgaatga cgggtggcgt cagcgtatca aaaaagacgg 2091661 cctccttcga gaccgccttt ttactgatta tgatgttctg ttttcttttg gattgatttc 2091721 agatcttttt tacgggcatc atcttcttca aaatattgaa caagatcccc gatgcgatca 2091781 atactgttcc agcttaaatg atgttcgatt ccttcgacat cgttatatat tttctcttca 2091841 tcaacaccaa tgattcttaa aaactgctca agcaattcat gtctgtatac cagccgtttg 2091901 cctatttttt tccctttaga cgttaacacg agaccgcgat atttttcata aattaaatat 2091961 tcgtctttat ctagtttttg aaccattttt gttacagagg agggatggac tgccaatgct 2092021 tccgcgatat cggaaactcg tgcatatcct ttttcttcaa tcagcatata aatctgttca 2092081 atataatctt ccatacttgg tgttgtcatc gaaaccctcc caaaaagcac cttaacttta 2092141 taaaccatta caagtttaca ctaatgaact tgaaaaaaca aggatgctcc gcgggtcaaa 2092201 agccctgttt accgcttata attccattca tctgaagcgt actttgtttc agccaagtga 2092261 tgaacaaaat caagctcttc ctgagaaagt tcatatggct ccaaatgaat gttaagacct 2092321 gtttcaaatc cttctttaaa ggctttacga gcctcatcca tcgtcacccg cttttcgatg 2092381 agttcattaa tggcaaccgc tttatttttg aaattgcgct gcatccgctc tcttactctt 2092441 tcacttggat ataagaacag atcgaacagc ttgtcctcat ctaaatcaag aagaatggag 2092501 ccatgctgaa gaatcacacc tttttgtctc gtttgcgcgc ttcccgccac cttgcgcccc 2092561 tcaaccacta gttcatacca cgaaggcgcg tcaaaacaaa cagatgaccg cggatttttt 2092621 aagctttctt tttctttttc agttctcggg atggcaaagt aagcgtccag accgagattt 2092681 ctaaagcctt gaagtatgcc ttctgaaata acccggtaag cctcagtaac agtcgccggc 2092741 atctcggggt gctcttccga aacaattacg ctgtatgtca gttcctgatc gtgcagcaca 2092801 cctctcccgc cggtcgggcg tctgacgaat ccgagattat atttatgtac tgcttcaaaa 2092861 ttgatttcct ttttaatatt ttgaaaatac cctacagaaa gtgtcgccgg attccagccg 2092921 taaaaacgga taaccggggg gattttcttt tcgctgtgcc aatataaaag cgcttcatca 2092981 agcgccatat tgaatgcagg acttgcattg cctgagtcta taaaccgcca agtttctttt 2093041 tgcattttaa gaccttcctt accgttttaa tagaatcagt ttatcaaact gtcgggaaaa 2093101 tgaaaaatat tttagttcca ttatagatga caatcacgct gtgctttact ataatagtat 2093161 ttgtcgaaaa cggctctatg accttgtttt atgaagcagg gttttgattt tatatgctaa 2093221 aggagtagaa tcacattgtc taatatgatc gttttgatta tttttgctgc atttatcatc 2093281 tatatgattg cttcatatgt ctatcagcag cgaattatga aaacacttac cgaagaagaa 2093341 ttccgcgcgg gttaccgcaa agcgcagctt attgatgttc gtgagccaaa tgagtttgag 2093401 ggcggacata ttttaggcgc ccgcaacatc ccgctttccc agctgaaaca gagaaaaaat 2093461 gagatccgta cggacaagcc tgtttacctg tactgccaaa acagtgtccg cagcggacgc 2093521 gcggcacaaa ccctgcgcaa aaacggctgc actgagattt acaacctaaa aggcggcttt 2093581 aaaaaatggg gcggaaagat taaagcgaag aaataaagca aacagctgtc tggtagacag 2093641 ctgtttttat ttatctttct tccgcctcgt atctgagcac tgggtgtctc gccgcttttg 2093701 tttcatccat tctttttaca atcgttgtat gcggggcctc ctgaacaagc tccggattct 2093761 cctccgcttc ttttgcgatt tgaatcatag catcaataaa cgcgtccagt gtttcctttg 2093821 attcggtctc tgtcggctcg atcatgatgc attcttcaac attaagcggg aaataaatcg 2093881 tcggcggatg atagccgaaa tcaaggagcc gttttgcaat atcaagcgta cgcactccca 2093941 gctttttctg ccgcttccct gataatacaa attcatgctt gcaatggcgg tcaaacggaa 2094001 gatcgtaata aggcgcgagt tttctcatca tataattggc gtttaacact gcgttctcag 2094061 taacagcctt taatccgtca ggccccatgg agcgaatata cgtatacgct ctcacattaa 2094121 tgccaaagtt gccgtaatac ggcttcacac ggccgatcgc atgagggcgg tcataatcaa 2094181 acgtaaagcg cccttctttt ttgactaaaa ctggctttgg caaataagga atcagatctt 2094241 gttttacgcc gacagggcct gagccggggc ctccgccgcc atgagggcct gtgaatgttt 2094301 tatgcaggtt gaggtgcacc acgtcaaatc ccatatcacc aggtctcgcc ttgcttaaaa 2094361 cggcatttaa attagcgccg tcataataca gtttcccccc cgcttggtgt acaatttccg 2094421 ccatctctgt aatctgctcc tcaaacaagc cgagcgtgtt cggattcgtc agcataagag 2094481 ctgcagtttc ttcattcact gctcttttta aatcctctaa atcaacaagc cctttttcat 2094541 tcgatttcac cgtaacggtt tcaaagcctg ctactgttgc tgatgcagga ttcgtcccat 2094601 gcgcggaatc agggacaatg accttcgtcc gcttgaaatc cccgcgagct tcatgatagg 2094661 cacggatcat catcagcccc gtccattcgc cgtgcgctcc ggcagcaggc tgaagcgtaa 2094721 cctcatccat tcccgttatt tcttcaaggt gtttgcttaa atcatataaa agctctaatg 2094781 cgccttgcac cgtgtcttca tcctgaagag gatgaatcgc agcaaaacca ggaatacgtg 2094841 cgattttttc attgattttc ggattatatt tcatcgtgca agaaccgaga ggataaaaac 2094901 cggaatccac cccgtgattg cgtttggaca gcgctgtata atggcgcatg atgtccagct 2094961 ctgaaacctc cggcagcgct gcgtcttcgt cacgaatata ggtgtctgac aagaggtccc 2095021 ccaattcgat ttccggtaca tcgagctccg gcagactata gccgattcgg ccttctcttg 2095081 aaagttcaaa aataagtgcc tggtcctgat tactcatggc gatcccccaa ttcctgaatg 2095141 agtgcgtcaa tttcttcttt tgttctcagc tctgttacag caatcagcat atggcagtcc 2095201 agctctggat acgtcaaccc aagatcatat ccgccaatca tgccttttgc cagcaaacgc 2095261 ttgttcacag ctctcaccgg ctcatccagt ttgatgacaa attcattaaa catcggcccg 2095321 tcaaacataa cagtaaggcc tgcttttttt gcttcttgct ttgcatagtt ggcttttaag 2095381 agattttggc gggctatatc ttttacgccg ttttttccga gagcagtcat ggccactgat 2095441 gctgccagcg catttaaagc ttggttcgag catatatttg atgttgcttt atcccggcgg 2095501 atatgctgct ccctggcttg cagggtaagc acaaagcctc tttttccgtt ttcgtcttcc 2095561 gtttgtccga cgagacggcc cggcaccttt ctcattaatt ttttagtaac ggcaaaaaag 2095621 ccgcaatgcg ggccgccgta tgctgaagga atgccgaaag gctgcgcatc accgacgacg 2095681 atatcagact gaaacttgcc cggcggagtg agaagaccta gcgccagcgg gttggctgaa 2095741 acaataaaca tggatttccc ttgatgagcg ataggctcaa tatcctttag cggctcgatc 2095801 ctgccgaaaa aattcgggta ctgaacgatc actgcggctg tgttctcgca aacggtttgg 2095861 cgcaatgcat caagatccgt aacgccatcc gcagcgggta cttcaacaac atcaatatac 2095921 tgaccttttg cgtaagtttt cagcacctct cgcgattcag gatgcacggt ttttgacaca 2095981 acaatttttt tctttttcgt gtggcctgaa gcaagcattg ctgcttctgc caaggctgtt 2096041 ccgccgtcat acatcgagga gttggcgata tccatgcctg tcagttcaca gatcatcgtt 2096101 tggaattcaa aaatagcctg gagctctcct tgtgaaatct ctggctgata aggcgtatat 2096161 gcggtataaa actcagagcg cgaaatgaca tgatccacaa tgacaggctg atagtggtca 2096221 tatacacccg ctcctaagaa agaagcgtat tgtacggtat cacgattttt agaggccagc 2096281 tttgtcagtt ctcttgttaa ttctgtctct gatttcgctt ttttgatttg atgctctttt 2096341 ttatatttga cgttttccgg tatatcagca aataaatcat cgatgctgct tacgccgata 2096401 gtagcaagca tctcctgttt atccttttct gttgcgggca aataacggtg cttcatgtgt 2096461 tgtctcctct ctccaagaaa aaatattagc gtttataaaa tggtgttttg acaacctttg 2096521 ctttcactaa ttttttgcgt atctctacat ctacaacagt cccgatctca ctcgtttccg 2096581 aatcaattaa ggcaaggccg acgttttttc ctaatgtcgg tgactgcgtg ccggttgtca 2096641 cctttccgac agacttgcca ttttggaaaa cctcatatcc gtgccgcggt atcccttttt 2096701 caatcatttc gagaccgaca agtttgcgct tcgctccgtt ttctttttgt tcactcaata 2096761 ctgacttacc gaaaaagtca gactcctttt tgtgctttac agcaaagcct atacctgctt 2096821 caatcggtgt aatatcccgg gtcagctcct gaccgtagag cgggagcttc gcttcaaacc 2096881 ggagtgtatc acgtgcaccg agaccgcatg gaatcaatcc gtatgcatcc cctgcatcga 2096941 tgattttttt ccaaatatgc atagcatcat cactgcggca gtaaatttca tacccgtctt 2097001 ctcccgtata gccagtgcgt gaaataagtg ctttgcggcc gctgatatcg gcttcatcaa 2097061 taaacgcaaa cggctttaat gcagacacat ccgcatctgt cagatttttt aagatcgctt 2097121 ctgctttcgg tccctgtaca gccaagagcg cgatttgatc tgactgattg tcaatctgca 2097181 catcacctgc tgcatgttct ttcatccaag ccaagtcttt atctatatta gaagcattaa 2097241 tgacaagcag atagcggttc tctccttttt gatagataag caaatcatcg acggttccgc 2097301 catccgggta acacatcgct gtatattgag cacggcctgg cgttaacgcg gaaacatcat 2097361 ttgtcatcaa tctttgcaaa aaagacagac tgtcgttccc tgacacttcg acttctccca 2097421 tatgagatac atcaaacaaa ccggctgcag ttcggacagc ctcgtgttct ttttttatag 2097481 aagaaaattg aacaggaagc tcccagcctc cgaaatcaat cgtttttcct ccatattcct 2097541 tatacaggtc aaataacggc gttcttttca gcatctaatt cctccccttt atcaacggcg 2097601 cagctaaaaa acatacaaaa aaggacagag aaacacctca tgtaaaatga aggttctctg 2097661 tcctggcacc tgaaagttta ctttgcatac gcaaagacgt cccctttggt ggtttgcgca 2097721 tccgcacaaa cactctccag agttgcgtcg agcaagagtt cttttgcctg agagattcac 2097781 tccgcagttt gctccttcgg cgcctgtatc ccgaggtttt cggtcaggtc tctccccttg 2097841 ctgtcattcg ctcatatttt catgctgtta tggacatact atagcaatat cttacatcaa 2097901 atacatactc atatcctacc atcatcacta tatgctgggc aacagcaatt tgggcagatt 2097961 tttcttatat tattcatctt aagaatcgaa gaataagaaa ggcggtttca aagcaatgaa 2098021 tacagaaatg atctacgatg caaaatggcc tgaagaattt gctgaaagac tgaaaaacga 2098081 tggcccttgg gcaaactggg aactgtacaa gctctctgca gaaatccaga aaacattagc 2098141 aattccagag tttgaaggct tacgggctcc tttatatctg ccttccttta cgccgctccc 2098201 ccaccagctt gaagtggcgc aaaaagtggt tgaaaaaatg aacgggaaag cgattttagc 2098261 agatgaggtt ggtctcggaa aaacggttga agctggactg attctaaaag aatatatgat 2098321 tcgcgggtta gcaaaaaaaa ttttgatcct tgtgcccgct tcccttgtgt cacagtgggt 2098381 caaagagctt caggaaaaat ttttgattcc ggctgttgaa caaaagaaaa gctatgtgtg 2098441 ggagcaatgc gatattgtcg tctcatcaat agacaccgcg aagcgctcgc cccatcgaga 2098501 aatcgttctg tctatcccat atgatcttgt cattattgat gaggcacaca aactgaaaaa 2098561 tagcaaaacg aagaactatg aatttgtccg gaatctcgta aaaaaatatt gcctgcttct 2098621 taccgcgacg ccaatccaga accgtatcga agagattttc aatttggtgt ccttattaaa 2098681 acccggccat ttaggcagtc agaatcactt tcaggaggag ttcgccaaga agaaatccag 2098741 tttagaagcg catgaacatt taaaagatct tgtgaataaa gtcatgatcc gtaacaggcg 2098801 gcatgataca gggctgaatt ggaaacagcg ccatgttgaa acagtgccga ttcaattttc 2098861 tccatcagag caggcgcttt atgatgaaat ttctcgtttg aaggacagta tcaataaacc 2098921 agccagcatg ttctcgatta tgaccttgca aagagaatgc tgttcgagca gagaagcggt 2098981 atatatgacg ctgaaaaaga tgcttgatca aaaagagaaa caagcacctg ccattgatga 2099041 ggatacgatt tcagttttga tagatcgcat caatcaagtg acacaaaact ctaaagcgct 2099101 tcaagttgtt gacttgatca aaaagatcga cgataaggtc atcattttta cagaataccg 2099161 cgcaacccag atttatctgc agtggtttct tcagcaaaac ggcatcagtt ctgtgccgtt 2099221 tagaggcgga tttaaacgtg gaaaaaaaga ctggatgaag gatcttttcc gcggaaaaat 2099281 ccaagtcctt attgcaactg aagcaggcgg tgagggaatt aacctgcaat tttgcaatca 2099341 catgatcaac tatgacctgc catggaaccc gatgcggctt gagcaaagaa tcggaagaat 2099401 tcacagactc gggcaggagc gtgacgtgca tatttataac atggcgacaa aacatacggt 2099461 ggaagagcat attctaaagc ttttatatga aaaaattcat ttgtttgaaa aagtggtcgg 2099521 tgaacttgat gatattttaa cgaaaattca agtgaacaat tttgaagagc accttcatga 2099581 cattttgtat cactcagcaa cagaagaaga aatgaaaata aaaatggata acttaacctc 2099641 atttttgtct tataaaaaac agctgcctgc tgaaaaaaga ggatcttagc ctgtaaggag 2099701 gttttattag tgagacagca agaggttcac gattttctgc tgcgtttttt tcaagcaaac 2099761 agctgccaaa tcgtcgatca aggcttaggc tatatgacag tgcagcttac agttgaaatg 2099821 gacaaacaaa tcatgaaccg ccctttctac tggcattggc gcgagaagac aggcggtgat 2099881 ccgaatccaa tgaaaatcac ttttattaca gataaagaaa atgcgccaaa agacctagat 2099941 ggtgaattta tatattttgg ggccccgcgt ctttttcaaa tattcaaagc tgttaaacaa 2100001 aatgggagat ttaccagaat gtatgagaaa attgaatcag ccggagctaa agtcccactt 2100061 cagccttggc ttggtataaa tgtcacgatt tcataccagt ccgacatgaa aaaggataag 2100121 ttattgtcac taggtcttca cctagtctct ggaacgataa ttgaagattt tcaaagcaag 2100181 ctgacccagt tttcactgac gtctcaaata tgtgactatt gcttcaccat ttcacctatg 2100241 atcaaaccag aaagcggact taagcgtatg gaaaactata tttccaaatc cgctatgcag 2100301 gagccgtccg actgggcgga acaggcggtt aacaggtgga agaatgatat gacattgctt 2100361 gataagtttt acgagcatat agaagaaaaa ccagaagaat accatctaga aaaacaggcg 2100421 ctgaaaacct tgtatcaacc aaagatatca gttgaaattg aaaatggcgg attgttttat 2100481 ctgcaaaata atatttcaag ctaacttttt taccattcga catcattctc gttttttttg 2100541 agaaaatacg attataataa aggtatattg gaaaaaaatt ctggtgattt aatggcaaat 2100601 gacttccaga gactaatgaa gcatacaata agtcatggcc ggactggctg aaatacataa 2100661 acaagtattt taggaggaga aactgcatga agaatgcaaa acaagagcac tttgaattgg 2100721 atcaagaatg ggttgaatta atggtggaag ccaaagaggc aaatatcagc ccggaagaaa 2100781 tacgaaaata tttactttta aacaaaaagt ctgctcatcc tggtccggca gccagaagtc 2100841 ataccgtaaa tcctttctga atgtgctata atatcacaag gaaggtgatg acattgattg 2100901 gccagcgtat taaacaatac cgtaaagaaa aaggctactc actatcagaa ctagctgaaa 2100961 aagctggggt agcgaagtct tatttaagct caatagaacg aaatctacaa acgaacccct 2101021 ccattcaatt tctcgaaaaa gtctccgctg ttctggacgt ctcggttcat actttgctcg 2101081 atgagaaaca tgaaaccgaa tacgatggtc aattagatag tgaatgggag aaattggttc 2101141 gcgatgcgat gacatccggg gtatcgaaaa aacaatttcg tgaattttta gattatcaaa 2101201 aatggagaaa atcccaaaaa gaggagtagt gcctgagcag aggcactaac tcctcttttg 2101261 tcaataacca tcgagacggc ccagtatatg aatactgggc cgtctctttt ttttgctgtt 2101321 attaattttt atcctcgcta tgcgcgagct cgtcttgctc agtattgctc attttttcaa 2101381 ttttttagaa atttttggga ttgttatgtg agaatttaaa tgcatatccc attattattt 2101441 ggtaataata aacaaagaaa gggtgacagc atgatgatca aacaatgtgt gatttgtcta 2101501 tctcttctcg tctttggcac cacagccgct cacgcagaag aaacaccgct tgtaaccgcc 2101561 cgccacatgt ccaaatggga agagattgct gtaaaagaag caaaaaaaag gtacccgctc 2101621 gcacaggtac tgttcaaaca aaaagtatgg gaccgtaaaa gaaaagatga agcagtgaag 2101681 caataccatt taactctgag ggaagggtca aaagaattcg gcgtttttgt gacgatttca 2101741 tttgatcctt atagccaaaa ggtcaataaa attgccatat tagaagaata tcaataaggt 2101801 cctccatttt ttgaaggacc ttattcgttt atttgcggtt attttttccg tttcagccaa 2101861 agtcggaagc catagggtaa aataccgaac cactgctggg aaacaggcgt ttttgtttct 2101921 ttccgcacct cttttcgttc ttttcgctca tctctcggag tatctatata tttgacaaat 2101981 tgctgcgtca tatatttaac ataatcattc gttttcacgt gatcacctca tcattcaatt 2102041 attatgagtg ttgtctcaca tgactttttt tatacccttt acactgtttt attctgtcca 2102101 tctcagcagt tttttctgtt tttggtcaaa cacgatctgt gcagttcttt ctgttcccga 2102161 atccgttgac actcttaagt tgatttcttt ttgttctttt atcgatgtat catgaatgta 2102221 ataagaaacc cgtccatata gaaattgctg cgtaccctcc tggcctttcc gttcctctag 2102281 aacatgccga atcgaaagaa gcaccccatt ttgaagcaaa ttctctccta tgtataactc 2102341 ttttgtttcc ttctcaaaca tgcagcgtga aatatattga gcagcaacaa agttcacgat 2102401 taacagcaca agcgctgaca caaaaagaac agctggataa ataaaccctc ttgtacgata 2102461 cattcacccc cctcctaaat acgaatagac tggaaaagca gtttgataca ctttttggtc 2102521 ttcactctca attttcagca aaacaacacc attttcaata tcagctttca tggcagtaat 2102581 atgatctaaa atcggaacat gccctttgcc atccactctt tttcttatca ttgaatgata 2102641 aatgtcaaaa cggatgtctt gtccggaaag attggtgcag attaacacgc tcccatgctc 2102701 ggctgtctta actgcctgtg attccttgca ttcattcatc atctgttcta tcgaaatcat 2102761 ccattcctgc tgtgtgaaac cgtcatgttc ctgctgtcga gacaaaaaca gatggataat 2102821 cgcagctaac gatcctgata tgagcaaaaa gactgagagc gaaaataata cgttaagaag 2102881 cgtgtagcca ttctgtctgc aaaatgctga ggcaaaatga tttttcttta taagctgcgg 2102941 ctttgataca tacgttttga tattcgccct cctcctccca cttcattgca tagatatgat 2103001 tgttctttgt aatcgttttt gacgcggctc cttcaccact catgacatat ttgctaatgc 2103061 tctcattcat catctgatag ccaatttctc gtgattccgc cattttttca tcagccatca 2103121 gcttgtccca caaggggacg actgtcagca gcacaaacag ccacaggctt agcgcagaca 2103181 ttgtttctat tgtagaaaaa cctttatttt ctctccacat tgactctccc gctccctaga 2103241 taaactgtta tgtcataaac ggcatggcct tttactcgta tttttccgcc tgcattcggg 2103301 tgccctttct cattaaattc caaacggtct tttaatgtca gcagttctat agaaagtccc 2103361 gttgcatacg gacgttcaat aaccgtatca ccaatgacta attgatattc ttttttatga 2103421 aagagaattt ttgttctttg ttgacgggaa atagcagtct gctgtgtgag cataatatca 2103481 tttttcagct gacttgctgc ctgtcggaca gctgtattgt cataagcagg aggaagtgta 2103541 gtgaagacgg ccaccaggag gatagaggca aggcttaaca caagcaaact ttctaaaagg 2103601 gtaaacccct tctcctcgtt taatttaatg ttcaacctta acttctccgc cggtgatgat 2103661 aatgcgctta ccatttggac agacagcatc ctttttcaca tagccctctg actgtaaatc 2103721 ggcaaggctc ggagtttgtc cttcatgatc aagctcaaat gcagtcattt gtgccttaac 2103781 catgttttgt aagccttcac agcccttttt ttgaatggtt tgattatgtt tcgtgacgtt 2103841 cggtatcgta attaaaagca aaatcgaaat aataaagagc acgattaaca tttcaacaag 2103901 tgtaaatcct ttctcattca tcagcctctt cctttcacat ttgattcatc atctgataca 2103961 taggcacaag catagataaa tacacaagta agatcatcgc tgcaacaaat ccataaatca 2104021 ttggctgaag gatgcctgtc catttttgcg ctttgtgttc cagccgctgt aatatgaatt 2104081 ggctgtatgt gaaaagctcc cgatccaatc ggccgctcag ctggccgtga gatatgactt 2104141 ttgataaatc agtttcataa aaaaggcttc cacaaatagc ggattcaatt gactcaccgg 2104201 cttttagccg ttcaatcaat tgttcagcct cgcagcggta gaaagggaga aacgtttgat 2104261 gtttaaatgc attaaggctg tcataaattg agaggcctga ttttaaaagg ctgcttagct 2104321 gcaaagaaaa aaagtagctg ttaaacagct ttacaagctt tccaaccaaa ggaatcctga 2104381 tacaaatcag catttgccgg gcaggtgatt ttttcttaaa cacaagccaa taataaatcc 2104441 cgatacctgc tgtaaaaaga acaagcaaaa tgatcacaag atcaatatgc tgaaaaaaag 2104501 caaaaagcat atcggttgaa cgtgaggttt ccatattcat cgattgatag ataccggaaa 2104561 actgaggaat gatgatggac tgtaacatat aaaacatgac agcgaccgta aagatgagga 2104621 aaagcggata gcgcagcact cttttcagct ggtctgcctg tgcaattttt cgttccagca 2104681 gctctccgct ctggatcatt gaagcaggca gttcaccatg tgtttcagca aaataacaaa 2104741 tacctacggc ttccttatga aatgacaaac tctttagtac ttgataaaac ggagcccctt 2104801 ccctcaaaca agtgaccgaa tcagtcaagt cagccgcctg cctcttattc atctgaagtt 2104861 ccatcaggcg taatccatcc agaagtgtat atccgcccgc agtcatttca ccgagcctct 2104921 ttaataacct ggcttgatcc tttaacaacc agacttttct aatctttttc atgataaacc 2104981 caccggtcat agttgtttgt cgttaaatag ccgagcgcaa ttccttttct gataatttga 2105041 cgaagcgttt gatattggta atttgcatga tttccttttg cctcctggat acattgctga 2105101 agatttttcc cgtatagaag ctcataaacg ctagctctcc tagtatttcg tgactgtcgg 2105161 caatacactg atgaacatcc gttttcacaa aacgggcaag ccaaatcaac caagcgctga 2105221 gccgctattg caatgacagt ctgttcgatt tcattcatat tgataccgaa ttcaagcagt 2105281 ctgtaaattg cgccctttgc gtctctcgta tgaaggctcg ttagtaccag atgtcccgtc 2105341 atcgctgccc gcaccgcaat ttcagctgtt tccgcgtctc tgatctcacc taaaataatc 2105401 atatcggggt catggcgcaa aattgctttc agacctgcgg aataagttac accggctttt 2105461 tcattcacct gaacctgaag aacatcttcg tcccttgttt caacagggtc ctctaatgtg 2105521 acaatatttc gattaaagtg tttttttgca tattgaacga gagagtataa tgtggtagtc 2105581 ttccctgaac cagtcggccc ggtaaaaatg agcatgccat gggaatgttt taaaaacgag 2105641 agtaatgtgg ctcctgtctt cggaaatagc gacaatttat caatcgaagg gatattgtat 2105701 tggggcatca ctctgatcac gaggctttct tcattaattg tgggcagcgt tgacattctt 2105761 aaatgaacat ttccctcttt caactttaac gtaagcgaac cgttttgcgg ctttcgcctt 2105821 tcacctatat ccattgctga aagaaattta aaatgtgaaa tcagtcttac gcactcttct 2105881 tttttcatgt cccttttttt cagcaaggca tgatcgaccc gaaaatgaat gatagcgtcc 2105941 cgctccctcg gcacaatgtg aatatcagaa gcctttgtta gatatgcctc ttcaatcaag 2106001 tttttgctta ccttttctat tgaatccaat ttgattccct ctcctttcaa cgcatattgt 2106061 agaaaaagaa gaaaaggtaa tcaaacaggg aaaacgtgat tttgtgagat gttatatgct 2106121 gaaaaaccaa ttctttctgg caagaaaaaa gactttcaac tgaatgtacc cctgtcatta 2106181 taattttccc tataaataaa aaagcagaca tggtcaccat gcctgctaga ttccattttc 2106241 attatgctgt tttcgcttat tgaccagtat ctttctcaac ggaaagatcg cctaatgcaa 2106301 caataccggt catttggtca ttttcaagaa tcgataaact gcggatttaa tgctctgtca 2106361 taagcccctt gacatcgtat ccggtcaccc tgatatgtct ggtgaaaaag cggggcacgc 2106421 tgcacaaaat atgaaacatc ctatagagtc cgcctttttc gaggtttctt tttcttcttc 2106481 cgctcctgca gcatatctcc cgtccagcct ttttttctca aatagagata gatcagaact 2106541 gtagatgtga caatcaataa gagggaaaag agatatccgt atttccaatt cagttccggc 2106601 atcactgaaa agttcatccc ccataaggca cccagagctg taatcggagt aaaaagcgtc 2106661 gtgaaaatgg tcagcgcttt tacaatttca ttccccctat gtgaggtaat gacttcctct 2106721 gaatgcagca gattgttaag ctccccttca aattcgctga tgtatgtaaa tcccctgtca 2106781 atcttcagtt gtgtccgctg ataatccttt ttcccttcat tttgaggtaa aaaggtttct 2106841 ttcaacgcca tttcaatttt tttagcgctt aatatcaaat ttttccaaat catcagttca 2106901 tggcgcagga gatggacgcg gtttaaaatg cttttgctat tgtcgtcttt aatttgccat 2106961 ctgagctttc tcagcttgac ttcaaattca tcaacaccga ttaaatacgc attcattagt 2107021 tcgccgagaa gaattaaaaa cccctctatc gcattgtccg ctctttccat ttgccgaaca 2107081 acttctttgc ctttaatctc tctcaaaatt gaaaagtcaa agttgattgt aaaaaaatat 2107141 tgtctggtga tataaaagtg aaaaacagta tggtcttttt cttcaccaag cccctgatca 2107201 taaacaatcg acccaaatac tgcttcattt tccgtttcag ttgtatctac tcgcaaaaaa 2107261 ttaacgtgat ggttattttc aaaccacttt tcacactgag gccagtgaga aaaatggatt 2107321 agatctcttg ccttacttct ttcttgaggc cccatttggt accaaaacca atcctttccc 2107381 gtatgtgcct tcatgtcaag ctcctccaaa cttttgttct ttattcttta attgcccaat 2107441 aaccgcgtca ctaaaccagt ctgccgcttc aacacatgtt ttatgagcat tttcaggtgg 2107501 tatggaatgt agaaagacat cggaaaaggg aggtgcatgc cttccttgga gaaggcagtt 2107561 gttttggaat ttatcaattt actagcagtc gctattctca ttttgttaac aggatttttc 2107621 gttgccgtag aattttcaat cgtaaaagtg cggcgatcca aaattgatca gcttgtcgca 2107681 aaaggaaaga aaggtgctaa agcggcaaag catgtcatca ctcaccttga tgaatattta 2107741 tcagcctgtc agctgggcat cacagtcgca gctttaggac tgggatggct tggggaaccg 2107801 actgtgcaaa ctctgcttcg accgcttttt cataaagcag gcttaaatga atcgcttacc 2107861 cacctgcttt cactcgtcat cgcattttta gtggttacgt atttaaatgt cgttattggg 2107921 gagctggcgc caaagagttt cgccattcaa aaagcagaaa gcattacctt gttgttcgct 2107981 aaaccgctta tttggtttta taagatcatg tttccattca tttggctgtt gaaccactct 2108041 gcccgattga ttacaggagt gtttgggctg aagccggcat cagagcatga gctggcttat 2108101 acagaggaag aacttcgggt cctattggct gaaagctata aaagcggcga gatcagaaaa 2108161 agtgaattaa agtacatgaa taatatcttc acctttgata aacgaatggc aaaggaaatt 2108221 atggtgccgc gaaatgaaat ggttagtttg tcactagatg aagactccat ttcaaatctt 2108281 caggaaacag tcaagcaaac aaaatataca cggtacccgg ttgtaagaga ggataaagat 2108341 aacgtcattg gcgtgattaa tatgaaagaa gtgctgtttt ccatgctgac gaaagatttt 2108401 tcaatcaaga agcatcaaat tgaacctttc gtacagcccg ttatccatgt aattgagacg 2108461 attcctattt ataaactatt gctgaaaatg caaaaggaac gcactcatat ggcgatcctc 2108521 atagatgaat atggcgggac gtccggtttg gtcactgtcg aggatattat cgaagaaatt 2108581 gtaggagaaa tccgtgatga atttgatgcg gatgaagtgc ctcatatccg cgaacttgga 2108641 aaggatcatt acttgttaaa tgcaaaatta ttaatcagcg atgttaacag cctgcttgga 2108701 accgatttat cagaggctga agtagacacc ttgggcggct ggtttttgac acaaaacata 2108761 gacgctgagc ctgaaagtgc catagaatat gatggctact cttttaaggt aaaagacatc 2108821 aacagccatc acattttatt tatagaagtt aaaaaagctg aatagcccgt gaaaggctgt 2108881 tcagctgcta tctttcaaga taaacatggc aaaggcatca acactctttt attttaaacc 2108941 ctttattggc cagggcttta gcaagacttt gctctgtttt cacattcgaa aaatccagac 2109001 ccagcttcac gacagtttgg gcaatttccg gcctgattcc tgaaataata gtctcaatgc 2109061 cgagcaattt ggtgctgtca atcactttaa aaatttgata ggctaccatg gtatcaacga 2109121 taggaacgcc cgaaatatct aaaaataaat acgagagctt taacgctgag cactgctcca 2109181 gcacagactc caaaatcgtc ctcgctctgt gcgtatcaat ttcaccgaca agcggaagaa 2109241 tcccaattcc atcagtaatc ggcataatcg gcgcactcaa ttcattaatc atttcttttt 2109301 gcgcgtttaa ttgtatcatg gtcacctggt gatattcttc cgtaaacact tcgatgatct 2109361 catcaatgtt ttgattcaag atccggctcc actcataaaa ttcctgaatg ctgatgtctt 2109421 gagaagaagc ttcgctgaat ttatgaatcc attcaaacat gatgtgcctg aaagtgttaa 2109481 actggccgac actttgtgta accgtcactt catgaacggc acggtctctg gcgcattgaa 2109541 gagaccaccg gttgagctca tcctctacgt cttcttttct aagggatttt gctacgatgg 2109601 tcaccaataa ttcatgctgg tcttttaact tttgttctag tttttgctga tctttcgctg 2109661 aatacagcca gctgccgttt gacgtacaaa cttccagcca ttgttgcgta atatcttttt 2109721 tgtgctctgt taagtgctga tcaagagcta tcatcttaat gagttacctc ctgtttttga 2109781 aaaatgtacg ctatatatgt ataacgcgtc tgcctttaca catactatgt ttagattcaa 2109841 tgggctatag ccaagcggta aggcaatgga ctttgactcc gtgatcgttg gttcgaatcc 2109901 agctagccca gtttctgaac aggtgaaaaa ccgaagataa gctgattcgt ataaatcagc 2109961 ggatcttcgg tttttcatca tgcagattga tgaaccgttt tcttcttcga taacttcaac 2110021 agttctcccg ggttataacc aatcaccagc tttttgttgt ctactagaat cgggcgtcgc 2110081 aaaagcttcg gcttctcgat taaaagttcc agcacctcat ttaccgtcat ttcttcaatg 2110141 tttaaattta aatttttgaa agtctggctt cttgtcgcca aaatttcatc aattccttct 2110201 gtcgttaacg ataaaatgta ctttaattct tctcttgtcg gggtttctct gaataagtgc 2110261 cgttcgttaa attcaatttg atgtgcttta agccaatgtt ttgtttttcg gcatgacgtg 2110321 cagcttggat atgagtaaaa agttaattgt tgttccattc gttttttcct cctcagttaa 2110381 ccatctcttt gtagaataac tacccggatc atttttcatt taaaccattt acagaacttt 2110441 tttcggatta ttttttaaaa aacattcata caatagaaaa cacaatcaaa gggacaaatt 2110501 ccatttgtat attaataatg aaaatgttta catttctagg tgtgatctat tataataaca 2110561 gtcagaggga ctctcgggag gggataaaaa tgaatcgcat gttccgggtg ttaggatttt 2110621 ggacgggaat ttttgcagtc atgttttatt taggtgatat gaaagatgct tcccttttat 2110681 tttttggaca gacgatctta tttgtgtttc tatcgtattt gaacttaacc gaacgcatgt 2110741 atatttatat ttttggcgct tatttaacaa ttttcttcgc cggctttaca tattactcaa 2110801 tttttattat ggtgcccggc ggcggaggcc attaaatgca gaaagagaca aaccttatcg 2110861 gtttgtctct ttttttacaa tgaaaaccca tttaaaaacg gattttgatc ctgctcagtc 2110921 agtacgtctg tttcaggtcc atggccgctt aacaccagcg tgtgttccgg aagcgtaagc 2110981 agtttttcat gaatggacgt cagcagcgtc tcttgattgc cgcctattaa atccgtacgt 2111041 cctataccgc cttggaacaa gacatctccg gaaatgacca agtctgcatc tttcacgtag 2111101 taagacacac tgcctggtga atgtcccggc gtaaataatg tttccaaatg aaacggcccg 2111161 atattcaact caccgtcgcc ttcaattaga tgatctgcag gcttagctgt gacttctatc 2111221 cctcgcagca tgccggagcc gtttaaagaa gcgtccgcaa gccaattttt ttcattttga 2111281 tgcaggtaaa cagggatatc ccatttttct ctcacttcat caagcgcccc aatatggtca 2111341 aaatgggcat gtgtaagcaa aatggctaaa ggcgtcagcc ctttttcttt tatgtattga 2111401 ttgattttat gtccctcgcc gcccggatca aaaatcagac attgatcatc actgatgaga 2111461 aaatatgcgt tcgcttgaat cggccctact ggcattcgtc tccatttcac tattatcacc 2111521 tctttctttt ttatgctctt attatgaggg tttttgaaaa aagattcaaa caatcgcaat 2111581 gaaaacgcta tcgacaaacc tataaaaaac aggtagaata aaactggaaa gaattgcagg 2111641 tttttcaatg taaagggggc tgtgttatgt tacttgtcgt gattttcggc cttgtcgctc 2111701 ttttcgcttt atggggagtc ttgcgttctg ttagaaataa aaatatactc gggtttttat 2111761 tagccggtgc caccttattt gtctttggat ggtttaccgt gatgaccgta ataaacagcg 2111821 ggtatccaac cgcacattaa aacctgtatc cgatcggata caggtttatt tttatggctg 2111881 taaatgttta ttgacacttt ctattttgct ctcaagcgtc gtttttttgt cacgcctgtc 2111941 atcgatacgg atattcgttg ccactctgtg caatcctttt tgaaatggcg cttcgtgaat 2112001 tgcctgaata actgcaaaaa ggtcactgag ttctccctcg atcagcgtat tcatcggtgt 2112061 cagctgatat ttgattttcc cttctgcttg atatccttct aatatctttt gcacatcggc 2112121 tacgtaagca ctgacactgg gtgtttccgt accgattggg ataatggtta catctgcgat 2112181 agccatcgtt attccatctc cttttgatca atgatgagtt gcttcgtttc atgtgatttc 2112241 aataaaataa tttgctcaaa atgaaagccg tataacgcat atttcccgtt cggagatatt 2112301 tgaatcggct ccatttcccg cagagacaca agatcttttg tctctcccga tgctacattg 2112361 attgctgcga gcttatatgc atcgccgctt tgtttgaatg tataaaacag gcctcctgct 2112421 tcatcatagt catactccat tggagccaaa cttgtatatt tcgcttggag cggccatttc 2112481 gctgtaacag gtgatgttga ttgcggcgtt ttaaactgat acgtcccttt tcctccggaa 2112541 gctgatttga cagtaaaact catttgatgg aaagaatcga agaatagaac gttatcctca 2112601 agcttctgtt ccgtcttaga agctgtatcg aacgtatata aaggccctgt tttatcgtct 2112661 ctaccctctt ttacataatc aaatgtattt ttggatgtcc aatgaatgaa cggaacctgt 2112721 actgggctta agaaagattc gtctttttta gcattcacct gatatgtatg gaaatcccag 2112781 ttttcattga attccgtcac catcatttga taaggatcat actgattcca agcagcttca 2112841 agctcatacg tttcgtaatc tttttcgtaa agcgtctctc cttctgcatt aagcaaaacc 2112901 actgccgtct tttggctatg tgtgatttgc agcagaatca tctgctccct cgcattgatt 2112961 tgaacatcaa cgatttgacc atccgtttga tagagctttt tcgctttgcc tgtaaagatg 2113021 cggtacgcaa aaagctctgt tttcgtcgga ttagacgcag tatataatat tgtgctgtta 2113081 ttcagccagc cttccgcccc atccgctttt tccgcggaaa gcggtatgat gtcttttttc 2113141 tcatcttttg ccgccgatgc ctgtttttgc tgctgatgag atggttcgca tgccgataaa 2113201 ctaaacagca ataccgccag cagaataaaa caaactgatc tcatcagcat tcccctccga 2113261 tcatctttat tctctcatat ttgcttcggc agaaaaaaga aaaagtttca gttactcatg 2113321 aaaaaataac gccctccaca agataccgct tgtggcgtta tatatgtgtg aaaactgctg 2113381 aaacggcaaa ggattttggc cttttccaag ttccaccgta tacccttcct taaaataatg 2113441 gtgaataaac caatcacgaa atccagcata gctgtctata tcccttactc ccttataaat 2113501 gttcccgctt aactcctcaa actcctttat gacggcagca gattcctcag gctcaaggcc 2113561 tttatagccc caataaattt cttctccttg agtatgaaga gccagcagtc tgtcaggcgg 2113621 attctccgtg atcagccggt acatcgcaat agattccggc tccgtaagcg gagagattcc 2113681 cggaaaatcg cggtagctgg gtgctgtcgg ttttcggtat ttttcaattt cccataatga 2113741 tggaaattgt ttatttaaat caaccccgtt tatattcgcc ttccattcat taaaatttgg 2113801 acgatgttca tttagccttt cgagttcatc tcttctggct cccatgactt ctgatccgtt 2113861 taaaacaaga tcaacgccat ccggattgac aagaggaacg agggataagg atgtgctgtt 2113921 aaacagcttt atgggagaaa agccaaagaa aggcgaattg cagcataatg acatacagta 2113981 ttccttaaac cattttagca ggacagacgt tgtaatccac tcattcgcat gaaatgacgc 2114041 gttcatatgg acctttttta cggcatgctc cccaccagcc ttcagctccc agataggcct 2114101 gccgagtaca gaacggccaa tttcccggca tgagacaaac ggaaaaacat caataatctt 2114161 ctttatttcc ttttcaacag ctgaatcatc atagattttc tcttgctcaa tccagctatc 2114221 tgaaagtttc agctgccgag gctgtaaaaa gcgctttatg tcctgaatgg tttgaagctc 2114281 tttgccgcta tgctcctcta tcacataacc agggcaatac aattgatgtt tttgtgcgga 2114341 gcgatttgca cttttaagca attcctcgtc tatcttcagt tctttcgcca cattggccaa 2114401 attgttcttg atctcaggtt tcaccgtaat aaacgccatc atcatccccc ttttttgtta 2114461 ctatatgaca gcgtatttaa aaaaagaaag cctcccgctc acttcgatgc gggagacatt 2114521 gtgattatga tgcctgatca agcatttgtt tttctttccg ctttgacgaa ttgtccagcc 2114581 ttttctggtc ataaaatcgc aacaaatccc cataaatgat ttcatcagaa agtgatagct 2114641 cctgttttgc tttatcagca aatgcttcac attgttttgt ctcttctaac ggttttcccg 2114701 tctctttgtc ataacacgca ccgtctgtat aaacaacctg atctgtgata aagctcccgt 2114761 cccggagcac cgtgaagtcc agtttttcgt ctgaaagcag atcgttgccg aattgaattt 2114821 gatctttcgt atcaatccct aaaagattca tcagcgtcgg cctgatatca atctgcccgc 2114881 ctactgtttc aatggtttgc ggctttttat cagtaatacc cggaatatga atgaccagcg 2114941 gcactttttg gagctgtacc tcttcaaatg gggttatttc ttttcctaaa aactgcccca 2115001 tcgcttcatt atggttttct gatataccat aatggtcacc atataataca ataacagagt 2115061 tgtcgtataa cccgtcttcc ttcagctttt cgataaaccg tttcagcgcc tcatcctgat 2115121 aacgcactgt cggaaaatat ttatttagcg tctggctgtt tgaatcatat tcatcaatca 2115181 attgatcctc ttcatcaaga tcaaacggga agtggttcgt cagtgtaatc agcctcgagt 2115241 aaaacggctg aggcagattt ttcatcagct ctgaggactg ctcaaaaaat tctttatcct 2115301 taagtcccca gccgactgaa ttttcgtcag ttacatcata cgagttaata tcaaaaaacg 2115361 aatcatatcc aaatgagtcg tacattaaat cacgattcca aaagctctta ttattagcgt 2115421 ggagcaccgc tgaatagtat ccgctgtttt tcaaaatttc aggagcggcc atatattgat 2115481 tgcccgcatt cgtaaaaaat acggcacctc gtccaagcgg atacagtgaa ttgtccacga 2115541 taaattcaga atccgaggtt ttcccctggc ctgtttggtg gtaaacatta ttaaagttgt 2115601 agctctgttt tataaagtca ttcagaaaag gcgtgatttc ttctccattc aatttttcat 2115661 taatcacgaa gctttgcgtc gactctaagg atacgagaat gacgttcctt ccttttgcag 2115721 cgccgaataa gcgtttgttg gcatccttcg cattagcggt tacgtagttt tcaatctccg 2115781 tcaggctgtt gctgtctgcc aacgctctct gtgcggattg ctttgactga agaacgccat 2115841 cgtaaatatg aaaattaaac aggctaatgt ttttaacaag catttctctg tcaaatgagc 2115901 gtgtcaatag ctgaggtctt tccgcctcag acaagcccag gttgaagaaa taaacagaag 2115961 caacgaacaa aaaataagcc gcccgttcat ttttcgttga gggaatgtcc gattgaaaag 2116021 ctttttgccg gatgtgaagc catattaaaa ccgcaatatc tacagctaat aggaggtctg 2116081 tcggctcaag aagtgttccg atgctgcttc cgagatcacc catattgctc gtttgaaaaa 2116141 gaacagggat tgttaagaaa tcattgtaaa aacggtaaaa aaccatattt gccagcaata 2116201 caaacgtgac aagacagctc atcgcgataa tgtagcgatt tctgtttttg ccttttaaaa 2116261 acaggctgag gccaaaaata agcaacaaaa aactcaatgg gttgataaac agaataaatt 2116321 cctgtgttag attgtcgatt ttaatatgaa aactggtttt gtaaacagca tacgttttca 2116381 gccacatcaa taaaatggca atcagcataa atgaaatctt cgaaaaaaac gtttttcgca 2116441 tttcaacctc ctatgcagca cgctcaaaaa aatcagtcta ttcccaacat tctcattaac 2116501 acatcaaatt aaatcttaac ctgagcacaa caaaaaatca atttcattta cacaatttta 2116561 acaattttga tgtttcagcc attcattttt agcgatccaa gcgcctccga taacgccggc 2116621 atcatttcca agtgctgcga ttgaaatatc agcagcttgg gctgcccgcg gaaacgcgca 2116681 tttgcggaat gttttctcga cttttgatct cagcagttct ccggctctcg atacgccgcc 2116741 gccaagaacg attttggatg gattaagcga gcttgccaaa tttccgagca ccaaaccaag 2116801 atgcttggct acataatcaa ccacctcaag ggcaatttca tcattttcac ccgccgcttc 2116861 aaacacatct cgcgctgaca attgttcggt tgcttttaaa cgtgtcgtct ttttagcatt 2116921 tgctattttt tcttttgcaa ttcttacaat tccggttgct gacgcaattg tttcgataca 2116981 gcccgttttg ccgcagttgc agggcgctcc gccttcaggg atgctgcaaa tatggccgat 2117041 ttctccgccg gcgccattta taccatgtac aatttcacca tttgcaatga tgccgccgcc 2117101 aactcctgtg ccaagcgtca cgagaatgac gtcttttgcg ccatcacccg ctcccttcca 2117161 catttccccg agcgcagcaa tattcgcgtc attttctata acagctggga tgccggtttc 2117221 tgtctccaga tggtttttca aagcataatt tttccaccct agatttactg tttcataaac 2117281 cactcctgcc gccatatcta cagggcctgg tgcacccatt ccgatgtatt tgatgatgtg 2117341 cttcggtttt tgcagctcat ccagcttgct gtcgattgtt tttgcaattg tgacagtaat 2117401 cgtgtcgccg gttttatctg tcggaacttc ccacttatgc tgaatttcgc catattgatt 2117461 aataaaagcg agtttaatcg tcgttcctcc caggtcaatg cccgcaaacc atatctcgtc 2117521 catttttatc accttagcct ttataaaaat ctcttccgtt ttttgtttgt tccaattctt 2117581 ttcgaaggac agctgccgct ctggcccact gctccttttc aatcatgtgg ttcatgtata 2117641 attcctttaa ttcatccagc ataaactcaa tttcaagctc tctgtctcca aaataaacaa 2117701 tgtggccaaa cgtttttaac agctgctgca catcataaaa tgtattcatt ttcctcacca 2117761 tttcttgaac ttaactatca taagcgtatt cataaggaag cggtcagtca agaagaaaac 2117821 gctgacaaaa aagccagctt cctttccata ttccacctct atgattcttt attgttttca 2117881 atttgccgct gcagctcctt gtagcgctgc tccttcggct tcagtttcac agccgtctgg 2117941 atggcctttt ctgcttgtgc aagctcattt ttttccgcat acaataacgc taaattgtaa 2118001 taggaagcat ggtctttagg ttcttttttc actgctcgtt ccaaaaggga aaccgcctga 2118061 tcatattcgc cgatttgaat atcagaaaca gcaagaattt tcaaaagatc ggcagaggca 2118121 tctttttgcg ctgcttctcc gttcagcaat tctgttactt cttcatactt tccttcctga 2118181 tacagctcgc ttgcctgctg aatcagcgct gactcctggt gtgaaggcga atgcaatccg 2118241 taatataaaa atccaacagc caaagcaatc agcaaaaccg ctgacaacaa tctttttcca 2118301 aaggctccgg ctttaggcaa ccccagtgct gctgcagcga aaaagccgcc aatcaagccg 2118361 ccgatatgtc ctgaattatc aatattcgaa accgcaaaac caaagcccag attgatgata 2118421 ataatgacaa taatattggt tcctatagtt cttaaaaaca tttttcgatt agacaaagca 2118481 acatacagta atgcacctaa gcatccgaat atggctcctg atgcccctgc cgaaggatac 2118541 gggctgaaca caaaactcgc aatcgaaccc gtaatgccag cagccagata aatcagcaaa 2118601 aatctccccg atccatacat ccgctcaacc gctgtaccaa ccgaccataa agccagcgta 2118661 ttaaaagcta aatgcgctat gccgatgtga agcacgatcg gtgtcagaag ccgccaccat 2118721 tctccttgtg caatcaggct gttttctttt gctccaaaag ccaccagtgt ctccgtatta 2118781 gtgctgcctc cgtttatttc gagcaagaaa aacatcagga tctgaagcgc aataaataaa 2118841 tatgtaaaag tcggttttcc gttttgaaaa accgccgctt cagtttttct ctgttcttct 2118901 tgtttcagca ctagcgaaag gaagcgttct cgcgccattt gcgcgttttc aaacgaagcg 2118961 tgttcctctg aacaatcttc tgtacgaaat gatggaaaaa ccgcttgaag atcatctcga 2119021 agcatcgttc ctctaacgat cgccggctca actgacacag ttcccttctc aaaagttttt 2119081 tttgcaatct cttcccagtc atcaactggg gcttccgttg aaaaaaacac gttcagcagc 2119141 ttcatccttc gtctgcccaa ttgatgtctg actcgttcta ctcgttcggc ctgctcttcg 2119201 atgtctctaa ccatttcttg acggaaatca agatcgtgct tataaagacg aactagatca 2119261 tgagaggact tgtccggcgc ttccagccat atttcatctg actcaccggc ttgtatgacg 2119321 ccatacccgc tattcaccag gtgcgccgca attttccaat atgtatactc cagcaaaaac 2119381 atgtttaccg ctccaatagt tttttttcat tataacagct ggcgctccga aacgcctact 2119441 gaaagcaaaa aatcccgttt ttcacgggat tttagaaagc ttgctgtata aacttattgc 2119501 ggataaatgg aattcttaaa aacaaatgga taaaagaccg cctgattcct ggctggctga 2119561 gtacagtatt cataagacgg tagcgatttt gataaaacat gacggcagaa accgcgaaaa 2119621 tggcatatat caaaagtttt ttcatgatat ccctcctgcc aatagggttt gttattctac 2119681 cttatttatt ctcgaataag ggacaggaaa gttatgaaaa acaagaaata atccgatcct 2119741 ctgttatcag cttatgtacc gggatgtcat gcggcagacg gggtacgtgc gcaaacaact 2119801 ggcactccaa aagcaaagag actgtcttcc cttcatattc acttaaatag cgatcataat 2119861 agccgcctcc aaagccgacc ctaaacccgt taacatcaaa acaaacaccc ggaacgatca 2119921 tcaagtcaat ttgtgatggg tttacttctt ttgttttttc aattaccggc tcgagcagtc 2119981 cggcgtacac ggtttcgagc tgatcatcag tctgatatgt gcgaaattgc attttcttcg 2120041 tgtccggatg gcattttggg atgcaaactt gtttcccttc ttcccaagcc tgctcaatga 2120101 caggacgcgt cggtatctct aatcctctgg aaatagtgac ggcaatggtg ccggcatttt 2120161 gccactccgg cagagaaaac aagtacttat acatacgttc cgttttttga agaatatctt 2120221 catttgataa agcagacagt gcctccagcg tcttttttct taattgtgat ttcatctctc 2120281 atccccctcg gaatagaaaa aaagccagaa cctttttcaa agctctggct tttttcttac 2120341 acctcaaaca gcaaagctgt tattttgttt cacggtgtaa cgtagatttt ttatcacgtg 2120401 ggcaatattt tttaaattca acgcggtctg gattgttgcg tttgttcttt ttagaaatat 2120461 agttacgctc accacattca gtgcaagcca aagtaatatt aacgcgcatt attttccctc 2120521 caaactaaaa tcatttactt attcagactt atatataata ccactataat ggacggaatg 2120581 ctaggctgtt tttcaatgaa ttgctgaatt attgaagata cgctcataaa gctgcaaata 2120641 tgatgacata atgagtcggg ggtggtggag cttgaacact tgttgtctgc cagcttcttt 2120701 tatccggcgg gctttttccc ggtcttttaa aaaactgtcc agcagatcag cagcttcctg 2120761 tacgagcgta aaatcagcga tgattgccgt tttgtcatga accgcataat cacaaaaacc 2120821 acctgactga gaaacgacag tcagcacacc ttgttccatg ctttcttgcg cggcaagccc 2120881 aaacggttca taagaactag ggaaaacagc catttcacag tgagacagta acgttctgat 2120941 atctttccta tttagaaacg gcagaaacat gacgcgatcc ttcaggttat atgccgcagc 2121001 caatttctca tagcaggaca gagacggccc ctccccagcc agcactagat agaggtcagg 2121061 ctgacgctgc ttcaagatgg caaacacctt taacagctgc gataatcctt tttccggaac 2121121 aaaccttcca tatgaaaaga ggaatcttct attcatgctt ctcgggattt tccccttctc 2121181 ttcctccata gatgcagggc ttgggataac ggttattttc ttatgtgccg ccttatcaag 2121241 agaccgcttc ataaatgtgc ttaatacgat caatgcatca gcggattcta taaggagccg 2121301 ttcggtcatg agcctgtatg ggtgtggggc ttctcggcac accttcttcc tttcgctttc 2121361 aagaccgtgg attgtcgcag caagcggaag gccaagccgt tgtttcaaat actgggcggc 2121421 aggggcagtt gtgtcatcat gggcatgaat cagatcaaag cgtttattgt gtgataacac 2121481 atggcgaacc attgtaaagt tagcatcagc tatgtaatct tcaaacttcg catacgaaaa 2121541 cagctgcccg ctcggagtaa aaaccgtaat gttgatatga gggtttaaat aggaaatgag 2121601 gcggtttaaa tggacaccga gcccgctttt cggctcatcg ggatgttcgg gtgaaagcat 2121661 gagaatgttc accgttcttt ttcccctctc ccataacagg tgtatgcaga aaattgcgcc 2121721 tcccacctgg tgtgcgcttc ttcaatctga aaactgttta tatgacgaat cccattttca 2121781 tcaagataga tgtcgtctgt accggcaagc ttgagagaga cattcattga attcacaatt 2121841 ctgtattcag cccgatatac agcatcacca gccgcctgtc taatcgtcca ttctccttta 2121901 tcatacgttg tgcgttttgt cctgacagct tcaatgtctt ttcttttgat gacaatgcgc 2121961 aattctttta tcatatcctg cgttttttcg aaaaggaccg cttcagccag ccgcattgtt 2122021 tcttctgaga tttcccagct tacggtcaag gtgtgagcgt tttgaatgat tatgtcgaat 2122081 gtgtccctaa aaaaggaaag cttatgtcgt atattatagg gaaatgggtg tttatccatg 2122141 gactcctaac attctccttt ccaatcgttc acttcgtgtt cctattaaac cattacatga 2122201 agaagaagcg aagaaagatt tctcgacaaa atctcgtttt tttcgcgaat tcctttagaa 2122261 actattggtt ttatggtata aaaaagaagg ataaaaaaag aatagaaggt gatgaaacgt 2122321 ggaaattgct attattgcgt tgtttatcgt cagtatagcg ctaattgcat tctcatattc 2122381 tcaaagagac ccgatgaaag atgtagaaca ggagctcgaa acactgcagc tttctgcgat 2122441 gcaggaaatt tacaagctca aaaagaaaat gacagtgctt gaggaagaat tactggaaac 2122501 aaaccttgtc attcgcaaat caaagcagaa cgacatcaat caaaaaatcg ctaaacaaat 2122561 actttctaaa tataataacg gtatgtcagc tgaagcgatt gctaaagctg aacatgtatc 2122621 agtggaagac gtgaatacga ttatcaaaga taatgagaag gtgctcgtat gacaaaacgg 2122681 ggcattcagg catttgctgg cggcatcatt ttagcgacag ccgttcttgc agctgttttt 2122741 tatctgactg acgaagacca ggccgctgct gtaaaagata ataaaacagt aaccgaacaa 2122801 gacgtgaaca attatcttga ttctaaaaaa ttggtttctg tcaaccgtga tgaatatcaa 2122861 aaacttctcg attcaaaaga gaaatcctta aacaatgaca gcggctcaga cacgaaatca 2122921 gacaaagtca aaacctacaa gctcaccatt aaagacggca tgagcacggc ggatgtatct 2122981 gctattcttg aaaaagaggg cattatctct tcggctcaag actttaatga ctatgtcatt 2123041 gatgccggct atcacaaaga aattcgtgcc ggcgagttta aagtaaaatc agacatgagt 2123101 ttcaaaaaga tcgtaaaaac gttaacacga taaaaaaaca ggctgactca gcctgttttt 2123161 ttcatccaaa ctttcctgaa atgtaatcga gcgttctttg gtccttcggg ttagagaaca 2123221 ttttattcgt attgtcgcat tcaacaagct cgcccatgta gaaaaaggcg gtttgatcag 2123281 aaacccttgc tgcctgctgc atgttatgcg tgacaatgac aattgtatat ttatctttca 2123341 gctctagaat gagttcttca atttttctcg ttgagattgg atctagtgca gatgtcggtt 2123401 catccatcag caaaatatca ggattggtcg caagtgctct ggcgatgcaa agacgctgct 2123461 gctggccccc tgacagcgaa agagcggacg tatgcaatcg atccttcacc tcatcccata 2123521 acgccacgtc ttttaatgac ttttccacaa tttcctgaag cttcttctta tttttggtgc 2123581 cgtggactct cggtccgtaa gccacattat caaaaataga ttgcggaaac ggattccctt 2123641 tttggaatac catgccgata ttttttcgca aatccacgat gtccacttta tcctttaaaa 2123701 tgttgctgcc attatagttc agctcacctg caagctttac attcggcgtc atttgaatca 2123761 ttaaattcaa tgtcttgata aaggtcgatt tcccgcatcc ggatggtccg ataatcgccg 2123821 taacctcatt ttcataaatg ctcaaattga tattttttaa agcatgatgc tgcccatacc 2123881 ataagttcat tccattgact tgatatactt cctgtttcat tacagcttcg gtagcaatac 2123941 tcattgccgc cctcctatcc gaatttcccg ttaatataat cctctgtctt ttgctttttc 2124001 ggactcgtga aaatctgttc ggtctgtccg tattctacaa gctcgccgtt taaaaagaat 2124061 gccgtccggt cagaaacccg cagagcctgc tgcatattgt gcgtgacaat aataattgag 2124121 tattctcttt tcaatcctgt aattaattcc tctatttttg catttgaaat cggatcaagc 2124181 gctgaagctg gttcatcaag cagaagaaca gccggcttca tcgcaagcgt tctcgcgatg 2124241 cataaacgct gctgctggcc gccggataac gagagtgcgg atgaatgtaa acgatccttc 2124301 acctcatccc agagcgctgc ttttgttaaa ctttcttcca caatttcatc taaaacagct 2124361 ttattccgct ctccggcata tttcaatgca tgtgtgatat tcgcatagat cgatttcgga 2124421 aatggatttg gtttttggaa aaccattccg atttctcttc tcaagctgac aacgttaata 2124481 ttgccgccca atatatttaa tccctcataa aggatttcac cttccgctct tgcagatgga 2124541 attaaatcgt tcattcggtt aatatttctc aaaaaagtag attttccgca tcccgacggc 2124601 ccaattaaag cagtcaccgc atttttttca atatccatgt ttacatgatg aacggcttgt 2124661 ttatttccgt aataaatgga cagatctttg acctcaagca cgtggttctg cttcggaaca 2124721 ataacagctc gctcaggttt ttcttttacc atttgttcag acatgttttt cgcctctttc 2124781 cgttctaatt tgccgtaagc tttttgtaga tcatcgtgcc aagccatctc gccgcgagat 2124841 taaacacaag aacagaaatc accagcacgg cagaaccacc gttggcaatc gcttcagcat 2124901 ccggaatcat tccttgtgta ttgacgttcc aaatgtggac cgcaagtgtt tcagcgggcc 2124961 tgaaaatatt aagcggtgat gtttccgaaa acgggttcca ctccgtaaaa ttaagacgcg 2125021 gtgttgtcag gcctgccgta aataataatg cggccgcttc cccgaacacc cttcctgacg 2125081 ctaaaattgc tcctgtgatg atagaaggaa tcgcacttgg aattaaaact gtttttacgg 2125141 tatgccagcg tgatacacct aaagcgagag aggcttcctt cagatcttta gggactgaac 2125201 ggatcgcgtc ttctgtcaca cgcaccatga caggaaggtt aaaaacagtt aacgcaagcg 2125261 ctccgcctat gatcgtataa ccccagcctg ttaagttgac aaacatcaat aatccaaaca 2125321 tcccaatgac aatagacgga agagatgaaa gcacctctat acatgttcta atgaagtcag 2125381 ttactttgtt attaggcgcg tattcagcca tgaagactcc gccgcccaca ccgagcggga 2125441 ttgtaatcag cattgtaata aacaaaatat aaaaggagtt aaacagctga tctcgtatgc 2125501 ctcctccagc tgcaatggcg ctcgactttg ttgtaataaa ttgaaaactg agctgagaaa 2125561 caccgtttat aataatatag gaaaacaaac ctactaaaat ggcagcgata atggctgcac 2125621 acaaaccaaa cattccggtc gccagtttat ctgttatttt gcggttcatt acactttcct 2125681 cctagatgac aagtagcgaa taagcaggat gaacaagaat gacatcacca gaagcacaag 2125741 ccccattgac cacagcgtat tgttttcaac acttccgtat gtggtgtggc ccatattcag 2125801 cgtgatgatc gttgtcagcg ttcccgcagt gtcaaacggg ctttccggca atactcttgt 2125861 atttccaatg accatctgaa cagccaaagc ttcaccgaac gcccgagcca tgcctaacac 2125921 aacagctgtc atcaatgttg gaaaagctgc aggcacaagt acttttctga tcgtctgcca 2125981 tcttgtggca ccaagcgcgt aagaaccctc tcgtaaactc ttcggaagag aagccattgc 2126041 atcagcagaa atcgatgtga tcgtcggcag aatcatgacg gaaaggacaa tcgttcccgc 2126101 caataaactg tgccctgttc cgctcgattt gaactgggcg ataaacggca ccaatactgt 2126161 aagacctatg aatccataaa caacagatgg aataccgact aaaagctcaa tcaccggctg 2126221 cagcactttc tttccccaat tcggggcaat ctctgtcata aaaatcgcac ctgcaatgcc 2126281 aagcggcgca gcgattagag cagaaagaat cgttactgca aatgagccaa aaataaatgg 2126341 cagcactccg tatttcggat cactatctgt aggattccaa tttaagctcg ttaagaattc 2126401 aattgggctt acaccattta caagaaaaga ttgcagcccc ttaacgccga ggaaaatggt 2126461 aatcgcaaca gatgccgcaa tcataatcag tgcacaagct gtgactatca ttcttccccg 2126521 aacttcatcc aattgccgat tttgcctaga gctgattaag cgctcgctca cagacatatt 2126581 ttctctattg tttatcattg ttttacactc ctatgaatgt gttaagagga gaaacggttg 2126641 tccccgcact cctcttttta ttaagatcag ctttgcttcc cgttggcatc acgtgtcact 2126701 ttcatatcag taaccggaat gtagccttgg tcagtaacaa tgcttttttg aatgtcttca 2126761 ctctttagat aatcaagaaa ttctttagct aaacctgtcg cttcaccttt tgtataagaa 2126821 tgttgataag cccagatcgg atactcgcca gttgctacat ttttcgcttc aggtttaaca 2126881 ccgtcaatag atagagcagt tactttgtca tctgttaaat atgagaatgc aagatatcca 2126941 atcgctcccg gagtatcagc aatgatcttt ttcaccgtgt tggaggaatc ttcagtaatg 2127001 ccttctgcag gctccgctcc gtcaagcgca tatttcacaa atgtagcacg tgtgccggaa 2127061 gaatcagggc ggtttacaag tgtaatcttt tggtctttgc cgccgagctc tttccagttt 2127121 ttgattttgc cagtgaagat ttttttcaat tcatcttttg aaatatcctt tacaccagca 2127181 tcagggttta cagctgctgc cataccaact acagcgactt gatgatcgac aagcgctttt 2127241 gcatcgatgc cttctttttc ttcagcaaaa acgtctgaat tcccgatctg aacagctcct 2127301 tcagagactt gagaaagccc tgttccagaa ccgccagctt gtacctgtat atcagcatca 2127361 gggttttctt ccataaattt ttccgcggct gcaagtacta gtggctgcat tgccgatgaa 2127421 ccagaaatgg ttaaagaacc tgatgccttt tcttctcctt ttgcagaatc gctattcgat 2127481 tttttacttt ctcctgcatt tccgcatgca gctgcaatca tcataaaagc agccatcaga 2127541 agcataagca ccaatttgtt ttttttcatt tcctgaattc cccctgcgta taatgtgtaa 2127601 tttgtcctac acgtatagag taaaggttct atgtaaaaag ggtttgaacc gaatgttaag 2127661 gttttgtaaa tcagtgcgtt tttttgtata aaaaaaacgc ccacatcatg tgagcgtttt 2127721 tttttagtta tcagaagacg ttgtgttttc tgcattttct tcaattttgt ctttattctt 2127781 ttgctgagta ccttctttgt cctgcttcga tttcagctca aaatatttat ccattacttc 2127841 cctgccgatt tcgtttgtaa ttgagtatct ttgattgtaa tcaatgtaag tccaaggaac 2127901 tacgacagaa atagcaatct caggattgtc agctggtgca taagccacaa gcgtcgtatt 2127961 ataagtgtct gttcctgttt ttgatttatc cggtccgtcg taaaatgatt gggctgttcc 2128021 tgtttttgca gctggtttat acgatgctga agccagttga cctgcagctg tccctttagt 2128081 ggcaacccgt ctaaaaccgg cttggacctc ttcaatatag ctactcttca tatcgacttt 2128141 attcaatact tcaggctgaa cagaatcaac gactgcgccg atcccttttt tcgcatttga 2128201 atctctgact tcctttacaa gctgaggctt catgcggtag ccaccatttg ctatggtgga 2128261 gacatattga gccaattcca gcggtgtata agtatcatac tgtccaatgg cgaaatcaag 2128321 caagaaacca gataatctgc ttgtaccttt atatcccgtc atttcatttg gtagatcaat 2128381 tcctgttttt actcctaatc caaattgact gaaataattt ctgaaggtat caaatgcaga 2128441 agtatccaaa ggcaatgctt ggtgaggttt atattcacct ttaccaactg caattgctgt 2128501 tttaaacata aaaacgtttg atgacttctc taatgcagtt tgaataccaa ccggccctaa 2128561 gttttgccaa gattttttcc ctcttttatc ctggccgata tacaatggtt catccttaaa 2128621 tacagtattc aaattaatcg ctccagtttg aagaccggtc aaaacggttg caccttttac 2128681 agctgatccc atagcgtagg atgaagtcat ggctcctaat gcataatcat caaacttata 2128741 ggctccattt tctcgtttaa tctgcttccc tgccattgtc agcacttcgc cgtttctagg 2128801 gtccatcatg acaacgaatg cacgatccaa caattcggta ctaggtcttg ctttagcagc 2128861 tttaagtttt ttctcaataa ttttttccac tgatttttgc aaatcaatat caattgttag 2128921 tacaagatct ttcccggctt tgccttcaga taccgttttt gttcccgtga cattgccttt 2128981 tgaatctgtg atattttcga cttttgcttt ttggccctgc agaaggcttt catattggta 2129041 ttccagatag ctttttccga ccctgtcatt tcggctgtag ccaagcgaca gataatggtc 2129101 gagcaagttg gacggcaatc cttcattaga gctggaaaca cttccgagca ctgagcgaag 2129161 aaggttttta taaggatatt cacgttccca atcggacgtg acatcaacac ctggcagttc 2129221 gtctaaatgt tcacttacca ctgccatttc cttcgctgat acatcttcgt ttttgatata 2129281 ttgaggggtc aatgcatagc ccgaatccat ctgtcttttg atagcaagga tctgcatatc 2129341 tttatccgtc aattcattca gctgcttatc agtaatccgt tttagctgaa gctggtataa 2129401 atcgtcatcg gatatttttt tgtcttcaac ctgctgtctt tctttagagc taatgagctt 2129461 tttcgcttct ttcggtctag tcaaaatcca ataatctttt ttatcccgtt ctgttacttt 2129521 ttttgtatcg actttgatca tgtcagacag cttttttgcg atctttaagc gctgttcttg 2129581 cgtggtcgat ttagatctcg tgtatgtgat tgcatttaaa gccttatttg tcacaatggc 2129641 attaaagttt cgatcataaa ttttcccgcg tggtaccgct gagctgactt cactttgttc 2129701 ctgcttattc gcttggtttt tgtaatcatc accttgcacg atctgcttga tgcccagttc 2129761 cacaataatc caggtaaata taacaaaggc agctaaaaat aaaatattca gccggatcgg 2129821 aagcgacttc tttttctctt tatgattttg cttttttggt ttatttctcc tcataacatc 2129881 accttttcta tttacagaaa gaaaagacac tcaagtaaga gtgccagttt tcattttaaa 2129941 ggttttttcg acttttttct acagataacc cctttttggc aaaaaaatta tctctcgcct 2130001 tttaaaaggg tcggttctgt tacccgtttt tggccgtctt cttccatggt ttcattttcc 2130061 ccttctttct ccttaaaacg aatatccttg acaaagtaat aaatcaaagg atgtcctata 2130121 cccaatatcg caagtgacaa aggaattccc acatcctctt tcagaagggc cacaatcagg 2130181 agaaagcaca aaatggaaac aattctgccg gcgttcaaga acatttctct aagcacgata 2130241 tattcaattc ttgcttttct ggcatgcctc gcgcgcccta tcacatcata tgtaagtgat 2130301 acatatggca caagcaacag aggatagccg atggcaataa aaacgccgta cgttaataat 2130361 gtcgaaaagc tcatatggaa cagaatcaaa aacagcgcgc catacaaaat aagtccgccc 2130421 agcaaaatcg atttttttct cgcctttttc ttaatcagcc tggatgcaaa gtagtaggca 2130481 aagaaggaaa cagctgaatt gacaagaccg aatgtaccga gagcaagctc gctgtttgtc 2130541 tcaataaata caaacacact gattaaaaag acaaaaatcc cttctctcaa accctgaaaa 2130601 aaatgcgcat tcgtgattct ccgccaattc atattgctat ggcgctctcc aaatactttg 2130661 ctcagcataa aacggccctt tgattctctc cgttttaaga aaaagctcat cacgacagcc 2130721 agggcaaata aactgaggga gagactgaaa atcactgtat aacccgtatt attttcaagc 2130781 cttgagatca cgaatccggc tacaatcggg ccgatcattc ctgcagagga agacagaatg 2130841 cccataaacc cgttgaaaaa gtctcgtgta tccggctctg ttatttcaaa ggtcagcacg 2130901 ttaaacgcta gccaataaaa gccatagcca actccgagca ccgcgccgat tagcacgagg 2130961 cggctggccg ccgtttctcc ggctaaaagc acacttaaat aaaaggcagc taaaaaaatg 2131021 acgccgaacc ttaaaatgaa taccctgtct atttttttgg ctaaccgtcc agccaaataa 2131081 aaggttatcg gctgcattgt cacaatggat aaattatata tcgccaaatc aataaatttc 2131141 cctgactgct tccaaagata cacattaaca aatgtattgg acagtgcaat tcccagcgag 2131201 taaagcccgc caatggtcag cagaaagagt aagcctttgt ttacgtctac atcgcctatc 2131261 acttttttta gtttgctcat tactgactcc cctttactat cccttagtct gtctcactca 2131321 aaccgagata tgtaaaaaga agacataaaa aaacaaggtc ccataatgag gaccttgttt 2131381 gtgccattat tttgcttcgc tgtatagacg agccacttcg tcccagttta caacattcca 2131441 gaaagctgaa atgtaatcag gacggcggtt ttgatagtta aggtagtaag catgctccca 2131501 aacgtcaaga cctaagatag gcgttttgcc ttctgaaagc ggagaatctt ggtttggcgt 2131561 gcttgtgatt tcaagtttac cgttgttcac aacaagccat gcccagccag aaccgaagcg 2131621 tccagctgct gctgctgcga attgctcttt gaatttgtca aagcttccaa atacactgtt 2131681 aatctcttca gcaagcgcgc cagtcggttc gcctccgccg tttggagata aaagtgtcca 2131741 gaataatttg tggttcgcgt gtccgccgcc gttgttgcgg actgcagtgc ggatgttttc 2131801 aggaacagaa tcaagatctg caacaagctc ttcaactgat ttgttggcaa gagcagtgtt 2131861 tccttcaacc gctttgttta aatttgtcac gtatgtgttg tggtgtttcg tatggtgaat 2131921 agtcatagtt tccttgtcga tatgcggttc taaagcatcg tacgcataag gtaattctgg 2131981 aagttcgtaa gccatgataa ttcctcctta gtatatatgt actgaaatgc cgcttcacag 2132041 cgagcctttc ttcattcaat gtaacaaaag aatgctttgt aatcaatgaa aaagctcacg 2132101 atttggctca tttcagcgga catatttcac tttaaccgat aatctgcccc attaaacctg 2132161 ccgccagcat ttcttatagg accgtccata aaaagtaacc gatcatcaaa agctgtatga 2132221 tgccctttgc aataacccct gttaaaaaac caatgagtga gccgaggcca attttaaacg 2132281 ctgactttaa gtccttctga tggacgataa gttctgcgca aacagccccg ataaacggcc 2132341 ccaatatgat ccctgcaacc ggaatgacaa aaggcccgat taataaaccg atcgtgcttc 2132401 cccatatggc agctttgctt cctccgaacc tttttactcc aagcagattc gacacgtaat 2132461 ctgctgcgaa taatactgcg gcaaaaactg cctcaacaag ccagaacata taagaatacg 2132521 gactgaatga aaataaaaat ccgtacaata caaatccggc aacaataaat actacgctag 2132581 gaataacagg atacaccagc ccgataaagg caatgataaa aaccgctgca atcaacagcc 2132641 aatacaacat atccatagct tccatcctcc cattttactc tgtcttcttc atgtcttcct 2132701 tgtattcaca cgcatgcaac gatacaataa gcaacatata ttagtttagc taggaagtga 2132761 agatagtgaa tgtgtttcag cttttcatta aaagtacata ctctccccgt gatattgcaa 2132821 aaacaagatt tcaaggaatc ggaaaagcga ttctttatgt atttttgctc tctgtcctgt 2132881 ttgcaatccc taccgcttat tatgtaagta cagggaccgt aaaatcaatg aacggcttta 2132941 aaactgtttt aaacaaagat ttccctgatt tcacaatttc aaacggcaaa cttcaaacgg 2133001 atgagaaaaa agccacggaa tctcaggcaa atggtttcgt tatcgtgttc gatccgacag 2133061 actcctatgg cactgaacaa attgaagcaa agcaaaacgc aatcggcatc cttcagaaca 2133121 aatttgtttt ggccattgac ggacaagccc aagaaatgtc ttactcaatg atgccgtcag 2133181 agttacagaa aaaagatgtc attgcaggtt taaaccaaaa taaagcgatg attgtaactg 2133241 ttctctcagc tcttattttt ctcgtaacag cagcgggaaa atttattgaa gtatcgtttt 2133301 tagcgcttat cgggttaatc attaagaatt cgcagaaaaa acatttatcc tatcatcagc 2133361 tctggaagct ttctgcttat tccatcacac tttcaactgt attctttaca atcatgcggg 2133421 cactagaagc aaccgtacca agtgaatttt tgctgaactg gtttgtcaat tttgtcatcc 2133481 tgtttctcgt tttaaaagag attccgtcca aaaaagtaat taataaaagt taaattatat 2133541 ttatttttat cctttaagta gagagtgtga aagcatttgc attaactttt tacttaaggg 2133601 atatttaata aaatgtatag agcttaaaca gatacattta taaaaaaagc tctacaatta 2133661 ctcaagaaca agctctggac aataatatca gaagtagtaa gatgtaacat gaaagaagtt 2133721 cttaacagca tttgacatat gtttttaaca aaataagaat aatgttaaat tttaactaat 2133781 agactagtta aaatcatatg gcaaaatatt ttgcatcctt tcacaacata tttacataag 2133841 atagttgcta tttaaaaagc caggtaccaa tagggcacct agctttcaga attaaatcat 2133901 caacaagtta gaattatctt ctttccttct attctcatta ttgaactgtt atcttttttg 2133961 tgggtttatg tatacaaatg cagctccctt agctttcccc ttatatactg ataaacctac 2134021 tgcccaaggt gttcctgtcg gttttggtaa tttactgaag taaaactttt tggttggagt 2134081 tctacttgaa aagtaccctg aatattgcgg gccaatgtcc ccaccctcaa ctatagatac 2134141 accaaagctc ttataattta gtttaccgca ttttccattt gtttcggcgt aagcatcaat 2134201 agatgttgca ctcttagtat atgtataagc atctgtaata actcttattt tacaaccaga 2134261 aataccactt accggttgcc aaccactgct tgcagcctct gctttttctt taggtgcaac 2134321 taccaaagtt aacattagta gcaaaattaa aaacacagaa aattttcctt gcttcatttt 2134381 gtagatcctc ctttaaacta ttacataatt atcctaacag atccattgtt cattgtaaat 2134441 aatggaatac gagttttata ttataaaagc ctctttttga tctaattttg cactattttc 2134501 tattttctat ctgaagttaa tgtttagtcg aagaaatcct gtcaaaaaag cgcctgtata 2134561 aaaaccgagc attcgcagtc tcttttcttt tgtcatgaat cgaaatggac aagcatacta 2134621 tggtataaaa tttcgtatgc gggaggaaaa gcgatgaagc gtctcacctt agtatgcagc 2134681 attgttttta tactttttat tcttttttat gaccttaaaa ttggaaccat acccattcag 2134741 gacctccctg tctatgaagc atcagcaaaa acggctgtac aagaaccggc ttataaaacg 2134801 gtgaaggtaa agccgggtga tacggttatg tcgatagtcg gatcagcagg ttctccggat 2134861 gacattgtaa aggattttga agcactgaat ccaaatgtga aagctaacgc cattcaagcc 2134921 ggaacagcgt ataaattccc ggtctaccct taatttaacg ttaatttctt gtcagttcgg 2134981 cgaagacact gttacaatgt aatttgtaaa ataaattcac ataaaccata ctagaattgt 2135041 tatatctaga agcggcaact acaattaagg agcgattgca agtgagtgaa atcacacatc 2135101 gtacaaaaac gcgtcccgtc aaagtgggac ctttaacaat aggcggcaac aatgaagttg 2135161 tcatccaaag catgacaaca acaaaaacac atgatgtaga agcaacggtt gcggaaatta 2135221 accgtttggc tgaagccgga tgccaaatcg ttcgggtagc atgtccggat gaacgggcgg 2135281 caaacgccat tgcggatatt aaaaagcgca tttccattcc tctcgttgtt gacatacatt 2135341 tcgattataa acttgcgttg aaagccattg aaggcggcgc agataaaatc cgaatcaacc 2135401 ccggcaatat cggccggcgc gaaaaagttg aagcggttgt taaagcggcc aaagacaaag 2135461 gcattccgat cagaatcgga gtaaacgccg gttcattgga aaaacggatt ttagaaaaat 2135521 acggttatcc gactgccgat ggaatggtag aaagcgcact tcatcacatt aaaattcttg 2135581 aggatcttga ttttcacgat attattgtca gcatgaaggc ctctgacgtg aaccttgcaa 2135641 tcgaggctta tgaaaaagca gcgaaagcgt ttgactaccc gcttcacctc gggatcaccg 2135701 agtcaggaac actgtttgcc ggcacagtaa agagcgcagc aggactcggc gccattttaa 2135761 gcaaaggcat cgggaacacc atgcgcattt cactaagcgc agaccctgta gaagaggtaa 2135821 aagtagcaag ggagcttctg aaatctttcg gcttagcctc caatgctgcc acgctcatct 2135881 catgcccgac ttgcggccgt attgagattg atctaatcag cattgccaat gaagtggaag 2135941 agtatatttc taagataaaa gcgccgatta aagttgctgt tctcggctgc gctgtaaacg 2136001 gacctggtga agcgagagaa gctgatatcg gaatcgccgg cgcacgcggt gaagggctgc 2136061 tgttccggaa agggaaaatt gtccgtaagg ttccagagga aacgatggta gaagaactca 2136121 aaaaagaaat tgacattctt gctgaggaac actacgcaaa acttgaagct gaaaaagcaa 2136181 aattaaaaga agaaacacaa aaagcttgac gggaacccgt caagcttttt tgtgttagaa 2136241 aaatggaata ataaatattc caagcactaa tgaaacgaca ccgataccca ttgcccaggc 2136301 tccaaggcct tgagcacctc ttcttcttgc gatatagccg acaataatac cagcagctcc 2136361 caataaaaca ggcagtacaa acaatgaaat gatggacaag gctaaagcga tgtaccctat 2136421 tccccgtcct tcattgacat tgccgccgct gcgatcattg tcttggtcat tgctgcggtc 2136481 agcagcacga taaggctctg cgatttcagc agctgtttcc tcaaaaaaac cgtcattgtc 2136541 gcgggtaata tttgtccctt cagatccatg atcaacatag taactgttgt tatcacgctt 2136601 ttcgtaatcg tttgccacct tcaattcccc cttctgtttt attaaaggag cttttatagt 2136661 ttgatccatt ttgcctgatt catgtttgct aaacttttct gttaatgtca attgtttatg 2136721 ttacacttga agggatgaaa ctgaaggagt gtgggcatgt tacgcttagg aatagatatt 2136781 gacggcacaa tcacggctca ggatacattc gtcccttatt tgaaccgttc gtttaatctt 2136841 tccatttcat taaacgatat gacggattat gatttaacaa agctgttaaa cattacccag 2136901 gaagaatttt gggattggat gaatcaaaat gaagcgatca tatataagga agcattgctt 2136961 gcacagcatg cgaaacagtc tctcgatctt ctcaaagagg agcacaagct tatttatatt 2137021 acagcgagac ggactcattt aactgatatt acttatgaat ggtttgacag acaaaacatt 2137081 cattatgacc acatcgaact tgttgggggt catcacaaag ttgaagcggt caagaatcat 2137141 aacatcgacc tgttttttga ggatcatcac gggaacgcca tgatgattgc gaaagaagcc 2137201 gggataccgg tgattttgtt caattcccct tataatcagc ttccgattga ttcaaacatc 2137261 atcagagtaa acaactggct agaagccgtt caatggatga acaacaacaa gcatcactta 2137321 atacgcgtca ataactgaaa aaggagccca aaccgggccc ctttttcata tatacgcatt 2137381 ttacgcagta gtgttttctt ggttttccgc tgtacaatca gggcatgtgc cataaatctc 2137441 aaatttatgc ccgctgacct gatagccatc caaatcatca caaagcttgt ccatcggaca 2137501 tgattcaatt tcctttgttt tgccgcaggc aagacaaata aaatgatggt ggtgatgggt 2137561 gaatgaacac ttaaatcgga agagcttttc accggacagc tcagttgttt ccaaaatccc 2137621 aagttcttca tataaagaaa gatttctgta gattgtatca aagcttaagc ctggataatc 2137681 atcattcagt gcagacagta cgtttttagc ggtaagatat ctgtctgaat cagcaaaaag 2137741 ctgcagcata tcctcccgtt tgtttgtata tttatatccg ttttctttta ataggttcag 2137801 cgcttcttgg acgttcatga agggtccccc ttttcgcttt gcttaagaac gtatcacatg 2137861 tatgaaaaag aaaatggcag ctgtctgtcc agcaagccat tttctttact gcagataaaa 2137921 ttatacccat aaaatgaata aaagtaaatg aaagcctagt ggattgcgtt tttgaatttt 2137981 ccgcctctcg tttcatgagt attcataatt gttatgaatg cattttgatc aacttcaaac 2138041 acgatcgatt tgagctttgt cacttccagc cttgtgacaa ccgcgtaaat tacgtctttt 2138101 tcttcgtccg tatacccgcc tttccccttc agcttcgttg tgccccgacc gagacggtgc 2138161 aaaatcgcgt cggaaatctc atcatactgc tcagacacaa taatgacagc ttttgtttca 2138221 tcaagccctt ggatcacggc atcaatcgtt ttcatcgcaa tataataagt catgaatgag 2138281 tacatcgctt gctcaggacc gaacacaaaa actgcccaaa tgaaaatgaa cacattgatg 2138341 aacataacga actcacctac agaaaacggg agttttttgg tcagcaaaat accgagaatt 2138401 tctgtaccat ccattgaacc tccatttcga ataacaagcc cgacgccaaa gccgagtaaa 2138461 agacctccga acacagtagc caaaataggc tgggttgtaa tggcttctac atggtgaagt 2138521 gaggattcaa taacggcaag cccgacaatc cctataaacg tagagactag aaaggtctta 2138581 ccgatatatt tatatccgaa gatcataaaa ggaatattta atatgacaac gaaaaaagcg 2138641 aaattcagaa aggggtttga cataaagagg tggtctaaaa taagagatac accgataatc 2138701 ccgccatcaa taaaatcatt ggggattaaa aataattcaa tacttacagc cgcagatgca 2138761 gctcctacca gaatcataaa gaccctgaaa ataaaatggg taaatgtttc tttcttatgt 2138821 tgttttgttg gggtcataaa atctcctttc ctgcaataac tattttaaat acattataaa 2138881 tctattttac cattaaacac tgacacattt tactgatttg cccatacatt aagtctggag 2138941 gtggaatgac cgatgatttt atttcaaaga attattttgc agcggcttaa tcaggctact 2139001 gctgatgatt tgctgaagta ctcaaaacaa tacggaatca gcttaacaag atcgcaggcc 2139061 gttgaagtag cgaacctgtt atacgggaaa aatgtaaaca tctttaatga gagtgaacga 2139121 atgcggctgc tgaaacaagt agagacgatt acatcgaaag aaacagctca aacagttaat 2139181 gaactattca aacaatttac aagctaaaaa atgggggtgt tatcccccat tttttattgc 2139241 tgtaaaatct tttcaagcaa tgtatcatca aattgttttt ctttcagcat ttcaatctca 2139301 aaacggtatg gcggtttttt gttcttttta tcttcaccga cgtatggtgt ttcaagaatt 2139361 tttggaatgt cttttaactg ctcatggtga acaacatatt gcagtgcgtc aaaacctatt 2139421 tcaccaaagc caatattttc atggcggtct tttctcgcac ctttgacatt tttgctgtca 2139481 ttgatatgaa gcactttaat acggtcaatg ccaatgattt tatcgaactc atttagcact 2139541 ccgtcaaagt cttcgacaat gttatacccg gcatcatgtg tatggcacgt gtcaaagcac 2139601 actgacagct gctcattgtg tgtaacgcct tcgataatct gcgcaagctc ctcaaagctt 2139661 ctgccgcatt ctgatccttt tccagccatt gtttctaatg caatctggac attttgattc 2139721 ggatcaatca cttcatttaa gccttcaata atttttttga tgccggcttc agctcctgcc 2139781 cctacgtgag cgccaggatg aaggacaatt tgcttcgctc cgatggccgc tgtccgttca 2139841 atttctgaac gaagaaaatc aacacccagc tcaaaagtgg acggatttgt cgtgttgcca 2139901 atattaataa tataaggcgc gtgtacgata atctcgtcaa tgccgttttc ttgcatatgt 2139961 gcccggcctg cttctatatt taagtcttca attttctttc ggcgcgtatt ttgcggtgcg 2140021 cctgtataga tcataaacgt attcgcccca taagagactg cttcctggct tgcagccaga 2140081 agcatatgtt ttccgctcat agagacgtgt gagcctattc tcagcaacag gttcccctac 2140141 tttcttttct tagattggtt tcttctctgt tttttcttga ttttctccat ctcatagctc 2140201 attttctttt tatacccagg cttaaccttc ttcggctttt tcacgagacg atgagcaatt 2140261 tcatccgctt cattcggcgt ttttttacgt tttttgcggc gctgacggtc atcgcctttt 2140321 ttccattcgc ccttttcaag ctctaagtac tcaaattcga tgcccatttt ttcaagtctt 2140381 actaatgcat cctcatcagt aagctcataa atggtcatcg cttgtcctga tgagccggca 2140441 cgagccgttc tgcccacacg gtgaacatag aaatcgagat catccggcag ctcatagttg 2140501 ataacatggc tgacaccttt aatatcaata cctcttgcgg caaggtcagt tgcaatgata 2140561 tatgtgaatt ccaaatcatt gatctgcttc atgacttttt tccgctcacg tggtgttaat 2140621 ccgccgtgca gcaagccgat tttcatgcct ttgccagtca gatactgggc aatatggtca 2140681 gccgtatttt tcgtgttggc aaacacaatc cccaggtatg gattcagatg cgacatgatg 2140741 tcaaaaagga gcttgtcctt gtcacgatgt ttcgaaggaa tgaggatatg ctcgattttc 2140801 gcagcagtca cctgttttgg ctccacatgg gcgtatttcg gattttccat gtatttcttc 2140861 aagaatggtt tcagcttttc cggtatggtc gctgagaaca caagcatttg cagatcctca 2140921 ggcatgcggg aaccgatgta atctacatct gcaaggaatc ccatgtccag cattaaatcc 2140981 gcttcatcaa taacaagaga ttccgcttta tgaacactta acgcctgttc tttgattaag 2141041 tcagcaatcc gtccaggtgt accgacaaca agatgcggct gtattttcaa tttatcaatt 2141101 gatttttgtt tatcagtgcc tccgataaaa catttcgagc gaatctgact tccttcttca 2141161 ccctgcgtga ttttaagcgc ttcctgataa atctggttgg caagctctct tgtcggagcc 2141221 gtaatgacta cctgaacgac atccttagca ggatcgattt tgtttaataa aggcagtaaa 2141281 taagcgtgag tctttccagt acccgtctga gactggccga tgacgctttc tttttttaac 2141341 actgcaggaa tcagcctttt ctggatatca gtcggttcgt aaaaaccaag gcgatgtact 2141401 gcatctataa taaatggttt caattcataa agttcaaatt tcgtttcttt catttttccc 2141461 agctccttaa agcggcacat tatgtgtcca tcatcacatt atacccgatt ttgcttaaaa 2141521 acaccacgtt tgcaaggcgt ttgttttatt cagttatgta aagcaaatac cgcagcccat 2141581 gcatattcta atagcagaga gagctgaaag gaggtacaag tatgttttca ccgcagcagc 2141641 caatgagaaa ttacccacag cccggaccgc cccgccccat gccaaatcag cgaatgatgg 2141701 gcagaagacc gcctaatatg cgaggacctt catttggagc acagcagcaa ggttttcagc 2141761 aagccggaca atttcttcct caggcaaatg ccggagcgag aaatggtgca ggtgcaggcg 2141821 gaggcttaaa aggaatgctg tcaaggttcc tccccggcgg aggaggcgct ggcagcgccg 2141881 gggttcccgg aattccagga gcaggtgcag cagcgagcgg aggtgctggc ctgcaaggca 2141941 ttcaaaatat tgccaatcct gcatcattat ccagtatgct tggaaatgtg caaaaagtac 2142001 tcggcatggc gcagcaagtc acccctatga tccagcagta cggcccatta gtccgcaatc 2142061 tgccagcaat gatgaagctg tacagccaat taagtaaaag tgatgatact gagacagagg 2142121 ccaatgagga aagtgaaaaa caatccgttt cagaagaatc atcagaaaaa gaaaaagaga 2142181 ctgaaacaaa aacctcagat gggaacaaaa aatcaaaacc aaaaagttct tctctcccaa 2142241 agaaatctaa aacaactgac aataaagaac aagaattaaa aacatctgcc ccgaagaaaa 2142301 aggaagctgc ctctcctgct ccgaaaagaa catcaggcag ttcaaaaccg agattatata 2142361 tttaacattc tttgatatct taagtgagat tggctataat gagatcagaa gaatgcaaga 2142421 atagagccgt ttgattacgg ctttttatat tgcctttact cacttcagta ttggaggaca 2142481 accgaaaatg gacgtaatta aaatttcacc gcgcggctat tgctatggtg ttgttgatgc 2142541 tatggtcatt gccaaaaatg cgtcgctaga taaaagcttg ccaagaccca tctatatact 2142601 cgggatgatt gttcataata aacacgtcac tgatgcgttt gaagaggaag ggatttttac 2142661 attggacggc tctaaccgtc tggacatctt aaagcaggtt gacaaaggaa ctgtcatttt 2142721 cactgcgcac ggtgtttctc ccgaagtcag aagaatcgca gaagaaaaag ggttagtcgc 2142781 aattgatgct acatgtccgg atgtgacaaa aactcataat ctaatcttag agatgaaaga 2142841 aaaaggatat cacgtgatct atatcggcaa aaaagggcat ccagagcctg agggagccgt 2142901 tggcgtagcg ccggagatcg ttcacttagt tgaaacagaa gaagatgtaa agaaccttga 2142961 tatccaatct gagaagttaa tcgtgacgaa tcaaacaaca atgtctcaat gggatgttca 2143021 cgacattatg gagcttgtca aagaaaaata tcctcatgtc gaatatcacc aagagatttg 2143081 cctcgctact caagtgcggc aggaagctgt atcagagcag gcaaaaaaag cggacttaac 2143141 aatcgttgtc ggagacccga aaagcaacaa ttcaaatagg cttgctcaag tgtcagagga 2143201 aatagccggg acaaaagcat accggatcgg cgacttaagc gaattgaagc tcgaatggct 2143261 gaaaggcgtt aataccgttg cagttacagc gggagcttca acaccgacgc cgatcacaaa 2143321 agaagtcatt cgctttttag agcagtttga tcacgaagat ccatcaactt ggacaactga 2143381 acataatata ccgctcaaaa aaatacttcc aaaagtaaaa gcaaaaaact gaggctgtaa 2143441 aagcctcagt ttttttatag aaatgtaaat ggatttgtat ctgtttcaga aacaaagata 2143501 ttcacgccaa actttttatc attacacatt gatgtaagtt ttctcgtgac gccttctttc 2143561 atgatttttt ccgcgtaatg gcccggatca accacattta ggccaagcat catcgcatca 2143621 tgggccacat ggaagtataa atctcctgtg acgtaaacat cggctccctt tcgttttgca 2143681 tgatgaatat acttgtttcc atctccgcca agaacagcta cttttttcac catgctgtca 2143741 gcatccccaa ccattctgac accattgacg tcaagcttgt ctttcacaaa taaagcgaat 2143801 tccttgagcg tcatctcatt tttaagggtt ccgacacggc cgagcccttt ttcggcggga 2143861 gtctgttcga caggatagat atcgtaagcg acttcttcat atggatggct ttttatcatt 2143921 gcattgataa cagccttttc gacgctttta ggaaatacag tctcaagcct tacttcatga 2143981 acaagctcaa gctctcccac ttcaccgata aaaggcttag ctccgtccaa tggcttaaag 2144041 ctgccgattc cttcagatga aaacgcgcaa tggctgtatt caccgatatg gccggccccc 2144101 gcatttccga gcgcggctct gacctgctct tcatattcct tcggcacgta aactgccagc 2144161 tttttcagag gatccgtata agtaggtgcc agcacttccg tctcactcag ctctaatgct 2144221 tcagcaagca aatcattcac accgccgtcc gcaacgtcta aatttgtatg agctgcataa 2144281 acagcaatat catgcttcaa acacttttca attaaccttc cggcaggctg atctgttgaa 2144341 atatgcttta gcgaccggaa aattggtgga tggtgtgcaa taatcaagtc aacctctttt 2144401 tcaatcgctt catcgataac gctctctaac acatcaagtg taaccatcac atttttaatt 2144461 ggtttgttta aggtgccgat ttgcaggccg attttatctc cttcaaccgc ataggctttc 2144521 ggggaaaatt gttcaaacag ctggatgatc tgctgcccat ttacactttt agccatgatc 2144581 gattacctcc tttaacagct ccattcgatc ggcgagctcc tttaattttt gtttgttttg 2144641 ctctgtatcc gccgcttggc tgatctgttc ataaatgctt tgagtgtgct gaagctcttg 2144701 tgtccacttt ttcaaaaaga cagcattttt ttcttttgcc aagaaagggc caacgagcat 2144761 cccggctgat aaagaaatac cgtcataagc cgcatccctg tctcccgctt ctgccaccag 2144821 cacctcatag cactttccgt cctcttcaag gattacctca tctatcagcg catatctttc 2144881 tttataaagc cactccctga tatgaacagc atgaatattc ggctgtaaaa tgagccgttc 2144941 cttccccgtt aatttgtctt tgcccgcttc taaaatgtga gcgatcaaag ccccgcccat 2145001 tccggcaatc gtaatggcat cagcttcacc ttttttaatc acttccagtc cgtctccctg 2145061 ccttacagaa atgtgcgagt ttaagcctga tttttcaacc tgccgctttg cagacaaaaa 2145121 tgggccgtct gttatttctc cggcaatcgc cccgctggct ttatgattca gcaccgcata 2145181 acaaggaagg taggcgtggt cagagccgat atcggccatc accgctccat tcggtatgta 2145241 ctccgctact gtttgcaatc gtttagataa ttttaattcg ttcacttgtc atcacaactt 2145301 ttctcaatca ttttttcctt tactatcata taaaaaatca gcccggaatc caagctgaag 2145361 caaatgattt tgaaattatt tcttttgatg cgggtctgca cgcagcagtc aaaaataaaa 2145421 ggctgtcgag aacatctcgg cggcctgtga atgtataaag agaaaaatag ttcttttatt 2145481 taatttttga cacccactct gccatatcat ccagcttatc ggccggaaca agaccggaag 2145541 gcattccatt accgcctttt tcgatctttg ttttaatttc agcgacatct ttcttatccc 2145601 ctacaccttt taagctagga cccgaaacac cttcataatt ttcaccgtgg catgcgatgc 2145661 agtttgcctt gtaaatttct tctggtgaag cgtttgcatc tttcttttca gcagatttgc 2145721 tttctcctcc gctcgcaatc tcccgagagt catcaagtcc ttttactgat aaaaagaaag 2145781 ttagaccaat tcctaaaaca gcgatcagca aaaatggaat aagcgggttc catttcattt 2145841 cccttccccc tttttgatcc ttccccctat gtaaacactt ctaattctaa cttattttta 2145901 caaaaagtaa atggattgct atacaaaagt tttttattca cactttatac aaaattgaat 2145961 agaaacatgc ctaaatctct aatatccttt ttattctatt gtataatgta ttgtatacgc 2146021 ttacaataga aaatatggaa ttagattttg aaatttttca ccacaatgtt catttgcaaa 2146081 tgacatcatt tttcagtaaa ataaaggcat attatccata tatcttttta aaaaaagaag 2146141 aacggatctt caagacccgt tccatcttat tcaaggaaat ctttcaaacg tttacttctg 2146201 ctaggatgtc ttagtttccg caacgctttg gcttcgattt gtcgaatacg ctctctcgtt 2146261 actccaaata ctttgccgac ctcttctaat gttcttgtac ggccgtcatc aagaccgaat 2146321 cgaagacgca atacattttc ttcacgatca gttaacgtat caagcacatc ttccagctgc 2146381 tctttcaata gctcgtatgc ggcgtggtca gaaggtgaag ttgcttcttg gtcttcaatg 2146441 aaatcaccaa ggtgcgagtc atcctcttca ccgatcggtg tttccagaga taccggctct 2146501 tgagcaatct ttaagatttc gcgtactttt tcaggcgtta aatccatatc ttccgcaatt 2146561 tcttcaggtg ttggttctct gcctaagtct tgcagtaatt gacgctgcac acggattaat 2146621 ttattaatgg tttcaaccat atgaacggga atccggatcg ttctcgcctg atcggcaatg 2146681 gcgcgtgtaa tcgcctgtct gatccaccac gtagcatacg tactgaattt ataacctttg 2146741 cgataatcaa atttttcaac ggctttcatc aggcccatgt ttccttcctg gatcagatca 2146801 aggaacagca taccgcgtcc gacataccgt tttgcgatac tgacaacaag ccgcaggttc 2146861 gcttcagcca atctgcgttt agattcttcg tcaccttctt caatcttttg agcgtaggcg 2146921 atttcttctt ttgcagaaag aaggttaacc cgaccgattt cctttaaata catacgaact 2146981 gggtcattga ttttaacgcc aggcggtaca cttaggtcat taaggtcaaa ttcttcttcg 2147041 gctttggcaa gctgctgaat attaggatct tctgtttctt cattctcact aattaattca 2147101 acaccttgtt cacctaaaaa ttcataatac tcatccattt ggtctgattc aatttcaaag 2147161 ctggacatac gctcagcaat ttcttcatat gtcaaaacgc cacgtttttt accagactct 2147221 gttaattgct cttttacttg gtcgaatgtt aattctgtct cgtgggtttg tttatcagcc 2147281 attatggatc cctccttcca aagcttgcaa cgaattctat aagcggtatg attcttattc 2147341 ggtccattca ggcgttttct atgtgaactg cctttaacaa tgtgcgaata atgaaatgac 2147401 aattcatgat gaggttaagc gatctatttg ctcctccgca aggaatcatt gccaataaat 2147461 gctcctcatc agttctccag ttattttaaa gatcggttca atgtaacgat ttcttgagcc 2147521 aaagaagcag ctcttaaaaa atctttttgc ctttctgctt cggctctttc cgcctctttt 2147581 tcttttatca ttgaccaatt tctttgattc aacacttttt ttacataatc tgataactcg 2147641 gcttcgctaa gctcttgatt aacctgaagc attaatatat cggacaagag ctggcttata 2147701 tgatcatccg tcaccctggc catcagatgc tgaggcgtca gctcggctcc ctcttcataa 2147761 aaagcataaa gataagcggc taatgcccgg tgctcatcaa tattaaattg aaaccctacc 2147821 cggtcaatca cttttttgat gacgctccga tctcgaagca tgtgagcgag taacagcctt 2147881 tctgcatttt catacgccgg acgcaaacgt ttttgccttg cttttgtcgt cagatgcgct 2147941 cgccgcgttt tagtttcacc gctattgtca gcaggtttgt tttgcttgct gaaaacagac 2148001 agctgctcag ttaaagactc ctgtgaaagc gaaaactctg aagcaagctg ctttacatag 2148061 acttcctgct ctagagaccc tgaaagcgtg ctgatttctt tcagtacgtc tttaatgtaa 2148121 gctaggcggt cgccttcatc ggacaggttc tttccttttc ggaaatattg cattttgaac 2148181 gccattacgg tgacacttgc gtcaataatg tcgtttttaa atttttcccc gccgaatttt 2148241 ttgatgtaat catcagggtc caatccgtca ggaatcattg caactctgac tttgcagcct 2148301 tttttttgca gaagctccga agcttttaag gtggcttcat aaccggcttt atcagagtca 2148361 tagcaaagaa tgatttcttc gacgtttctt ctcaggatct tgacatgatc atctgtaaga 2148421 gacgttccca tcgtggctat gctttccttt acatccgagc ttacggccga tatgacatca 2148481 gcaaaccctt caaataagac tgctctttcc tgctttctga tatgaaggcg ggccttataa 2148541 aaattgtaaa gcagtttgct tttatgaaag agcggggttt caggactgtt catatactta 2148601 ggctgctggc tgccaagagc cctgcctgag aaagcaacaa cagccccgtg atgatcatgg 2148661 atcggaaaca tgacacggtt tctgaagcgg tcgaaatatc cgcttccgtc ttcgcgtctg 2148721 atcaggagac ccgctttttc catttgcgcc tcactaaatc ccctctttac aaggaatttc 2148781 gtgataaagt cccaagaatc aagagcatag ccaatctgaa attcattaat cagctctttc 2148841 gtaaagcccc tagaaagcag ataatccagt gcctcttgac cttcttttgt atttattaac 2148901 aaatgatggt aaaatttctt caggagctca tgtgcctcag ccattttttg ttctccagaa 2148961 gactctggcc gggctccgga atggactgtt atatcatctg gaaaatcaat ttggtatttg 2149021 tcagcaaggt gagaaaccga ctcggcaaaa gaatagcctt ccatctgcct taaaaaagag 2149081 aaaacattgc cgcccgctcc gcagccaaag caatgaaaaa tctgtttgtc gggcgatacg 2149141 gaaaacgaag gtgtgctttc tccatgaaaa ggacagagtc caaagtagtt tcggccttgc 2149201 ttctttaatt gaacataatc acctatgact tcaacgatat ctgccgactt ttgcacctga 2149261 tccacaattt catctggtat ccgatttccc atcttataac actccgtcgt acattattcg 2149321 atgctttagt gcaaaatccc ttcatcgttc gacaggattt tttgcagcag tgtaataaat 2149381 cgttctcgat cttctttatt caatttttta ggccctttgg catatacgcc ttttcttctt 2149441 tgtttgccgg aaaaatgacg gccctctagg gcaaaatcaa tcgtgtcttc cttgtaaaga 2149501 cgacctcttt ccgacataac agagacattt ctgttcaaca gcagagatgc taatccgatg 2149561 tcctgcgtca caacaatatc tcccggtttc acgtgatttg cgatatataa atcagcagct 2149621 tctttatgag gatcaacata cttccatttt tcttcattgc ttctggaaag ctgataatgt 2149681 tcaaatgaag cgacaaaaag aacttgaact tcatactcgg atgctgtttg taaaatttca 2149741 tcttttaccg gacaagcatc agcatcgaca aaaatcgtct tttcttgttc attaagaaga 2149801 gtaattctcc atccctccat taaactcctg cataaaagca agcaaaatcg cacatccttt 2149861 attattgtgg atgtatatga atttgtcgaa aaatttccgg gagaaattct tgacatctta 2149921 cccataatag tttattcgta tcacacgatc cttaaaccta aaattaatca ttttatcaca 2149981 attttttatt ataatacaaa cttcacaaag atgctattgt ttttcattat tcccttttgg 2150041 cacagccaaa aacccaggat agagcgtcct gagttatatg ttttttgttt tgagatgatg 2150101 gataatattt gctgtttcct caaccgcttt atttgaaaca tcaacaacct ggcagccgat 2150161 ccgatccaca atcttttcga aatactcgag ttcctctttg attctgttga tatttgcata 2150221 aatcgcttta tcattaagcc cgagtgattt taaacgttct tttctgatat gattcagttt 2150281 atcagggcta atctttaaac cgatgcattt tttcggatca acgttaaaga gttcttccgg 2150341 cggatcaacc tccggtacaa tcggaacatt ggcaaccttc aggcgtttgt gtgcgagata 2150401 ttgagacagc ggtgttttag acgttcttga cacgccgatc aaaacgatat cagcttttaa 2150461 aatccctctt ggatcacgtc catcatcgta tttaactgca aactcgatgg cctccacttt 2150521 tttgaaataa tcttcatcaa gctggcgcac ccgccccggt tcgtatttcg ctgttaaacc 2150581 gtaggctgtt tccattttat caatcaacgg gccgataata tcataatata aaacatttgc 2150641 tttttccgct tcggctatca aatattctct gatttccggc accacgagtg taaaacagat 2150701 aatgccgccg tctgcctttg caagtgaaat cacttcattg atagtgccta tatcttcaac 2150761 ataaggaatt cttcttacat gagtatcatc cgccgatccg ttaaattggc tgagtgctgc 2150821 ttttactacc aattcagccg tttcaccgac ggaatccgat acaacataga tgatgcggtt 2150881 attcatatta tccccccgtt agtttgcaat cttataggat ttcattttca gataaactga 2150941 caagtatttt ggtcatattt gtttttgtca ctctgccgat cacttcaaag cctttatcgg 2151001 tgtctttgat gacaggcagt gcatcaattt gtttttctat taagtgcttt gcaatgtcca 2151061 tcacataatc ctcgcgtctg cacaccgtaa tgttcggcat ccttgtcatg atgatgtgaa 2151121 cagggaccga tgtaagctcc tgctggccaa tgctcgctct gagcaagtct tttcgtgaaa 2151181 gcaccccgac taaaacagca tcgcggtcca ccacaaacag agtacctaca tcttctaaaa 2151241 acatggtgca aatcgcatcg tacacagaaa cgttttcgtg aatcactacg gggatagatt 2151301 gaaagtcttt cacctgaagc tttttgagtt tatccgccaa aagctgtgtg ccggtttttc 2151361 ccgtatagaa ataaccgact ctcgggcgcg cctcgaggaa tcctgacatg gtgagtatgg 2151421 ctaaatccgg gcgcaatgtc gccctggtta ggttcagctt ttctgcaata tgctcccctg 2151481 taatcggccc gttttctttt acaatctgca aaatatgttc ttgccgttta tttagttcga 2151541 tcgtactcac caccttttca cttcatagct atgtaaagaa ataacaatcc atattataac 2151601 gtaaatatct tgtaatcaaa caaaaaactt ataaatgggg aaaagacgat taccgatcac 2151661 acagcaaccg ccttttctct ctttatttta caataagggc attcatattc gcaaaggact 2151721 tgatctcatc cgccaagctt accatttgcg ctaaacgatt tgcctttaat gactcattat 2151781 ccgctataac cattgtatga tcgaagtaag catcgatcgg ttcttttaag gctgcaagtg 2151841 aagcaagcgc cgcctcataa tcttttttgc tgaagttttc ctgcagattt tgcttcgctg 2151901 tttggtaggc atcaaacagt tttgcttcgt attcattttc aaacagatca ggctgaatgt 2151961 ctccgcggac tccttttttg ctgatagaga tcactcggcc taacgcttcg gctgtttcct 2152021 taaagccagg tgcaccaagc ttttgctcca gtacttgtgc tttatgcagc gcagagtacg 2152081 gctcaagctc agagctttcc agcacggcgt caatgacatc atgtctgatt tgttcagcat 2152141 tcaagacata tttcaagcgc tgagtgaaga aatccagcag ttcattttct ttatcggttt 2152201 gaacgaaagt aagcagctct tcaaatgaaa ttccccagtt gcggtcaaga agaatcgcaa 2152261 caataccgct tgcttggcgg cgcagtccgt aagggtcctg ggaaccggtc ggaattacgc 2152321 cgatagagaa gaatgaagcg attgtgtcaa gcttatccgc cattgctaca acagctccgg 2152381 tgaaagtaga aggcgtttct ccgcccgctg atctaggcat ataatgttca ttaactgccg 2152441 cagccacagc ttcatcttcg ccaagcattc tcgcatactt ttcgcccata attccttgaa 2152501 gttcagggaa ttcatatatc atatgcgtca caaggtcgaa tttagaaatt tcagcagccc 2152561 gcttcacatg ttttaatgta tcttcatcag cctgaagacg aacggcaagt ttctctgcga 2152621 ttgatgtgac tctcctaacc ttatcagcaa gagaaccaag ctcttcatgg aaaacgatat 2152681 tttcaagctt cttcacattt gcatcaatgt ttagtttctg atcttctttg tagaagaatg 2152741 aagcatcaga taaacgtgcg cgcagcactt tttcattgcc tcgggccaca ttttcaatcg 2152801 cgtggctgtt gccgtttcgg actgtgataa agtgaggcag caggtcaccg tttttgtctt 2152861 tgacagggaa gtagcgctga tgctctttca ttgtcgtgac aagcacttct tcaggaattg 2152921 acagaaactc ggattcaaat gaaccgtaaa gagctgtcgg gtattctact aaatgattca 2152981 cttcatcaag aaggtcttcg tcaactggaa tgctccaatt gttttcagca gccattgttt 2153041 ccagctgaga ttgaatcatt tgctttcgga cgctaggatc agcaataaca tgctgtcctt 2153101 tgagctgctc ttcataagct gaaggtgatt caattgacac ttcatgtccg aggaaacggt 2153161 gtccctgtgt tgtccgtcca gactcaacgt ttgtgatcga aaatggaatg acatcctgtc 2153221 caaataatgc gacaatccat ttgatcggtc ggatataacg caaatcttca tttccccagc 2153281 gcatgttttt cgggaaatgc aagcttgtaa ttaaaccgct caattctggc agaagcgact 2153341 tcgtttcttg gccggcttgg aatttttgca cgaatacata ctctatgcct tttacttctt 2153401 tgatgtacag gtcttccaca tttgcgcctt ggccttttga aaagccgatt gccgcttttg 2153461 tccagttccc gtccgcatca agggcaattt ttttcgcagg cccttttgct tcttctttta 2153521 tatcatcctg cttttctgcg acatccttaa cgaacacagc aagacgtctc ggtgtattga 2153581 agagtttcac ttcaccgtga gtaatatttt tttctttaag ccagcctgtc agcttgtcgc 2153641 caagctgaac catgctttca ttcaaaaagc gcgccggcat ttcctctaat ccgatctcta 2153701 aaagtaaatc ctgtttactc atgagaagaa ccctcccctt taagcattgg gaaccctagt 2153761 ttttctcgtt cctcatagta ggtttttgct acttttctag ctaaattccg cactcttgcg 2153821 atatagcccg tccgctcggt aacagagatc gcacctttgg catcaagcag gttgaaagtg 2153881 tgcgagcatt tcagcacata gtcatatgct ggatgaacaa gtccgttgtc catttgcttg 2153941 atcgcttctt tttcatatgt gctgaacaat tggaacagca tatcgacgtc tgatgtttca 2154001 aacgtataaa cagaatgctc atattcagcc atcatgaata aatcttttac tgtaaaccct 2154061 gacgtccatt ccaagtcaaa cacgttttct ttatcctgga tataagacgc gagacgctca 2154121 attccatacg taatctctac agaaacgggt ttacactcta atcccccgac ctgctggaaa 2154181 tacgtaaatt gtgttatttc cattccgtca agccaaactt cccagcctag acccgcgcag 2154241 cctaaagacg gattctccca gttgtcttca acaaagcgaa tatcgtgctc aagcggatca 2154301 attccaagag cacgcaagga atccaaatac agctcttgaa tgttatcagg tgacggttta 2154361 ataatgacct ggaactgatg atgctgatac agtctgttcg ggttctcccc gtagcggccg 2154421 tctgccggac gtctggaagg ctctacataa gccactttcc acggctcagg accgatactg 2154481 cgcaaaaatg tatacgggct catcgtgccg gctccttttt ctacatcgta agcctgcata 2154541 agcacacagc cctgactgga ccaatgcttt tgcaaggtta gaatcatgtc ttgaatattc 2154601 atttcaagca cctccacttt tctttcataa gttgactgcg gcagcaacca aaaaactccc 2154661 gtctctatgc ttgccagccg caaacatagg gacgagagtt ctcccgcggt tccaccctag 2154721 ttgctgagaa caaaatccca gcctcttttt taaaattgct caagaatgcc tttcgttgcg 2154781 tgctcatcct tagcttacac cgccctaagg tcgctttcat gaggtaaacg caagtacttc 2154841 tttctctcac tgcaacatat tttataataa atgatcatat aaaaagatgg accaaatgtc 2154901 aacttttgtt ttcacccata agatgtttca tgctttccat ttgatctaaa aagcgctttg 2154961 attttaaata caatcccgaa tattcttcgt aatataaatc aatcacttgc tttaattcag 2155021 cttttgtttc ctcttttaag gacacattgc cgagtctcga cagatcaaaa tagtaaaaga 2155081 gccttaacag ccttgccgtt tgcggtttaa tcggtatcct gtaaggatct ttttcaaaac 2155141 agcggtggca tataaaacca ttatcacgaa cagagaaatg aaaggttccg tcttggcttt 2155201 tacaatgtac acaatgattc agctcaggat acaggcccat gacaccgagc atcttcattt 2155261 gaacaatgaa ggtgataaca tccggatctg ttccttcatt caactgtttt aatgattcta 2155321 atatgaattc aaataaataa ggatttggct ttttttcttc tgtgcctctg tcgactaact 2155381 cagcaacata ggcagcatat gctgttaaaa acaagtcttc cctgatgcct ctcatgctga 2155441 ggatcatttc cccctgctga agcgttccga ggcccgatgt tttttgcatt aagaaagaac 2155501 catacaaaaa gggctggctg actgctgata aacggctgtt cggttttttg gcgcctcgtg 2155561 ccataacacc tatttttccg tgttctcttg tcagtaatgt tacgatttta ttcgtctctc 2155621 cgtaatcatt tgtgcgaaga acgatccctt cacattttgt cagcatttcc gcaccttcct 2155681 caagcaggag cggccaagag gtttataaaa ttggataatc aaatcgggct agctcatctt 2155741 ctagttcttc gggtctttcc atgttctctt tttccagttc tttaaaaaga agatacgtat 2155801 caacatttcc tgtttgagaa aatacgttcc aggtaaaatt caacacaaga aacccacctt 2155861 tctgtagtta aactagctta cctaaactcc aaattcttac ctttatcttg accagatgtc 2155921 ctccatttca tgttaaacaa aatttgctaa tgtatccctg ttcctgtgag ataatgacac 2155981 acacgggaag agattaatat tcgtcctctt taaagccaaa atcgcgaagc tgggacattt 2156041 tattacgcca gtctttctgc actttcaccc acaattcaag gtagacacgg gagcccaaca 2156101 gtgcttcaat atccgctctc gctctttttc caacctcttt tagaaggctt ccttttttac 2156161 cgatcacgat gcctttctgg gaatcccgct cgaccacaat cgttgccgct acgtgcacag 2156221 aaccgttgtc ctgccctttg atggattcga tggccaccgc aatgctgtgc gggatttctt 2156281 ctctcgtcaa atgcagcacc ttttccctga ttaattcaga aatgataaat cgttcagggt 2156341 ggtcagttac ctggtcactc ggatagaatt gcggcccttc cggcaaatac gcttcgatct 2156401 gcgcgagcaa ggtttcgatg ttatttcctt ctaaagcaga aatcggaaca atttccttaa 2156461 aaggataacg tttgcggtat tcgtcaatta gcagaagcaa ttggtcggga tgaattttat 2156521 caattttgtt tacgattaag aatacaggcg tagacatcgt ctgcaatttc tcaatgatga 2156581 attcgtcgcc cttcccgtag ccttcctcag cattgatcat aaacaagatc aaatcgactt 2156641 cttttaatgt attttgcgcc actttcatca taaagtcccc aagtttatgc ttaggtttat 2156701 gaatccctgg tgtgtcaata aaaatggttt gtgatgtgcc tgtcgtcagt actccttgca 2156761 ccttgtttct cgtcgtttgg ggcttatcgc tcatgatcgc gattttttgt ccaatgactc 2156821 tgttcaaaaa tgtagatttt cctacgtttg gtcttccaat aatggataca aatcctgatt 2156881 taaagctttc gttcgtcatg taaatcctcc gatgaaaatg cgcctggcaa taattcttcc 2156941 acagtcattt cttttatttg tccttgtaaa ttagtcagta cgacaataac gtcttttgtg 2157001 caaagctcag aaatcacctg tcggcaggct ccgcacggag atactggtcc aggggtgtca 2157061 gccgcaacgg ccagcatctg aaactctgta tccccttcag aaacagcttt aaataaagcg 2157121 gtacgctcgg cgcaattgca catgctgtat gccgcgttct caatattgca gcctctgtac 2157181 acttttccat ccttggtaag aagagcggct cctacttgga atttggaata cggcgcatat 2157241 gccatatcac gcgcttttaa agcttctgtt attaattctt gtctgttcat gtgtacattc 2157301 ctctcttacc tataatggta ccgctatcac tttatatttt acataatcgc gcgctttttt 2157361 tcacgcccat ttctaaaaat gtaaaataaa tgtaagaatt ttcagccatt acagctttgg 2157421 caaaaaaata agtaaaccaa tgatacacga aatcacggca aaaacgcaaa cagccccggc 2157481 ggcagcgtcc ttggccgctt tagcaagagg gtgatgtttg tcagttatta aatcaaccgt 2157541 atgttcaatg gctgtattta aaagttcaag cgaaaacata ccacctatca aaaggaatat 2157601 aatcatccac tcaataatgc tgagctctac aaggaagccg caaatgagaa cagcgcaggc 2157661 ggctgcggca tgaaattgga aattccgctc cgtccgcgct gtttcccata tgccccggcc 2157721 tgcatgcacg aagcttttga agaatcgatt cagctcattt ctatgatctt ttgagtccat 2157781 aagcgtccag caattccttt tgcttagtaa acatctcctc ttcttcctct ttcgtcatat 2157841 ggtcatatcc taaaaggtgc agaaatccgt gtacagctag aaatccgagc tctcttttaa 2157901 aagaatgatt atactcctct gcctgctctc ttgtgcgatc ggcactgatg ataatatcac 2157961 ctaaaaccgg aggcatttcg gcgcccacga tttcgatctc gccttctccc tcttcttcaa 2158021 gagcaaatga gatgacatct gtcggagcat cctttccccg gtattctttg ttaatctgat 2158081 gtatgtcatc attggaaaca atcgtgacag aaacttcagc ctgatcctga acgccttcac 2158141 gctcagcggc aaattgaagc agattttcta cttctttgag catctcttct gagacgcttc 2158201 ccgtttcatc aacgatatca atcagtaaac tcatctattt caccttctta gtagcctccg 2158261 gatattcaat ccgggagtgg aaaattcctt ttaatgttgc acagagcgtt tttgcgattg 2158321 tatccagctc tttaaatgtc aaatcgcatt cactgaactg tccgtcctga agcttatcgg 2158381 atataatacc ccggacaagc ttttcaattc gttcaggatt tggattgtgc atggatctga 2158441 cggccgcttc aacactgtcg gccactgata taattgcggc ttcctttgac tgcggcttcg 2158501 gtcccggata acggaactct tcctctgtaa tctggtcgcc tttttccttc gctttatagt 2158561 aaaaaaactt taaaagcgag gttccatgat gctgctcagc aatatcgaca agctctttcg 2158621 gaaatttata gcttctcagc atattcgcac cgtctgtcgt atgcgagata ataatatttt 2158681 tgctcaactg aggtgacagc ttgtcatgcg gattgtcaat attcatttgg ttttcaataa 2158741 aatattgcgg gcgctttgtt tttccgagat cgtgataata tgcgccgact cttgcaagca 2158801 aaccattagc cccaaccgct tcacaggctg cctctgataa attggcaacc attacactgt 2158861 gatgatatgt acctggtgtt tccgtcagta ttttgcgcaa tagcggatgg ttaggattag 2158921 acagctcgag cagcctcatg gtggataaaa tgccaaagcc cgtctcaaaa aacggcatca 2158981 gaccgatgat caatacagat gaagcaaacc ccgacacaac ccccatgagc attaacgtgc 2159041 cgatttcaag acccgacagc gcagtgttct ggatcaataa taaggataga acgacaacca 2159101 tattaataaa cgccacgaaa agtccggtct gcaaaatctt tgatcttgca ttgtgttttc 2159161 ctaaaaataa tacacctgaa atgccgctga tcaaataata aatccctatg acataattga 2159221 atgttcctgt cacaccctga ttaaacatca tacttccgca aatcgcaaga atgatacttc 2159281 ccaaaatggc aatgcgttca ttcatcagca gtttgattaa gatggcgccg gccgcaatgg 2159341 ggaccagata gccgatatta ttatactcca tcttctgaaa caaactgaca acctccatga 2159401 tcacaagcaa aagtgttgtg attatggaga ataacagaat ggattggttt ttaaacttca 2159461 gattttgttt ctgtttttca aaataatata caagtgttgc aatgaaaagt ccgatcataa 2159521 tcaatagccc gctgatcggt ttaaagagat ttgagttatt taataacccg gtcagctcaa 2159581 gtttcctgta cacttcccga tcaatgaggt cattttcttc cacgagcact tgcccctgtt 2159641 tgatttgaac ctgctggaca ttatctgagg cttcctgccg ttttgcctct gttgctttcg 2159701 gatcgaagac gtaattcgga ataatagcaa aacgcccgat ttctgtcgcg gctcccaagt 2159761 atttagacgg aatagaattg ctctttagct ctttttctac cttatccttt gcatcagata 2159821 gtttatccga agggatttca ctgctcatga ccgtatttac cgcggtaatg accgtatctc 2159881 tgacaaaaga aaagtcttca ctgtctgctt tcagcaatgt cttgatggaa tcctccgata 2159941 tagaatcatt cacatctgat gtcaatttgt cctttacaga tttgaccatt gatttttccg 2160001 atggtgattt actgccttct tccgatgatt ttttcacttc actaatactg tcgaatattg 2160061 atgacacaag gtcaatccga ttgtctgtat attctttttt taatgtatat tgatcttcaa 2160121 ccgcgtcctc agcggcttgc tttttttcct ctgtggcttt ttgatcttct acggttgccg 2160181 gagcgtaaat ggtcttgtcg ctgactgaaa acaggtctaa atcaagtgtt tccggcttaa 2160241 catgtacaaa gagcaaagca aacataatgg cagccagcag aagatacagc agtacatgca 2160301 tggagcgggc atttttaaaa ctgctccatt tttttgagct gcttttggtc ttagccttct 2160361 ttttcaacac aagaacctcc tcttgaaaca tcaagcccat aagcaatcat aaaaatgacc 2160421 cgataacgcg cgatcgggtc attcagcatt aattttgctt atcgtatgct tcaataattt 2160481 tcgcaacaag cggatgtctg accacgtctg tctggtctag ctcaatcata gaaatgccgt 2160541 ctattccttt cagcatctcc ttcgctactg caagtcccga tttgacgcct ttcggcagat 2160601 caatttggct aacgtcacct gtaatgatca ttttagagcc aaaacccagt ctcgtcaaaa 2160661 acattttcat ttgagcaggc gtggtattct gtgcttcatc aagtataaca taagcatcat 2160721 cgagcgtccg tcccctcata tatgcgagcg gagcaatttc aatgatgcct ctttccatca 2160781 gacgttctgt atgatctgcc ccaagcacat catggagagc gtcatacagc gggcgcaaat 2160841 aaggatctac tttttctttt aggtcacctg ggagaaaacc aaggctttca ccggcttcca 2160901 cggcaggtct tgttaaaatg atttttttga tatgtccgtt ttttaaagca tggactgctt 2160961 ttacgacagc caggtacgtt ttcccggttc ccgccggacc aatgccgaat acaaggtcat 2161021 tccgcttcat agcggccacg tattcccgct gtcccattgt ttttacacgg attgatttgc 2161081 cttttgcgtt ttttgtaatt tcttcttcat acatgctttc aaagtattca agttcattct 2161141 tctttgccat tttgatggcg taaatcacat cacgttcaga gatctctatc cccttgcgaa 2161201 ttaaagcgag gagcgatccc agcagcctgt ctgcaatctg aaacgattca tcatcgcctg 2161261 aaacataaat cgtctcgccg cgcgtaatga tatttaaatt cagatctttc tccatcaatt 2161321 tcaaaaaaga atcttggttc ccgaagagtg aaagcgcctc gtccgggttt ttcagttttt 2161381 gattcatcgc aagtaaatgt tctgtcattc ttcagtctcc ctgacaatag gtgtggtttg 2161441 aacgatatct tctataactt ggtagagaat aatcaacttt actttaccat tctcaacagt 2161501 ctggtgcaaa actttttcac ttttcacctc gccgttttcg cctattttat cctctacatc 2161561 ctgtttaccc aatttaatgc cttcttgaac tgcttcttct tttgtatatt ttcgcaaagc 2161621 ctcttcactt tctctcgttt gctctttgac ataggataca gggagcttaa atccgagaaa 2161681 atgaagcgaa tgcttttctt gttctgtttt tggatgcttc aattcctctt ttttaaacgt 2161741 catcccccag atcgggattg ccaaagaacc aaaagaaagc ttgtgctttg tccttacttt 2161801 gcccgtatag acgttaaata atgtttcaag cgggactgtc acttctgatc tataccaggt 2161861 ttctccataa atttctgctt ttgaggcgac ttcctgctga tggtcttcgc tgccgatcag 2161921 tcccgaaaca agcagctgtc ccttttcaac atgatcgtgt atggcggcca tgggctgtcc 2161981 tttttgcaca aacattctcg taatggttgc tttctttttg gcgacaatat tgcgcgggct 2162041 aacatatttt tctttttcgg gctcattttt ctccacaact ttcatatgaa tggtcgtccc 2162101 cttcagatca actccgaccc aagtgatatt gtctattcca ttggttaatg atttctgtat 2162161 tttttcgggc gacatcatta aaaactgcag acggcccttt ttgacgccga tttcattaag 2162221 atgctgcctc atttgatgtt ctgtttcagg cttagcgcct gtcacatcaa ttttccacac 2162281 catattggac agcaaaaaca aaagaatgaa aaaaatcgca aaaccgatcg taaaccctat 2162341 attcagcttt gatttcagca acaggaaggg aaatcccttc cgattgataa atcgggcttt 2162401 acatttaaat ttacttctta cccgccgaaa ggcatgtaca tcctgaagct gtatatataa 2162461 cgatacggct tctttctttt ttttgacatg aaagaccgga atcccctgtc ttgtgcattc 2162521 attaaggagc cgctcaatcc ctcttcccgt caattcaagc tggaccttac ccgaaaaaaa 2162581 agacagccat ttatttttca caacatttcc ccctcggctt tatgactcaa catatcgaac 2162641 gacatcaatc gtaccctcca aaagtatctc ttccggaaga atcgccttga tgacaaaatt 2162701 tttaccagat atgatgcact ggccctgctt cagcatcagc cgcacttcat tctcactgaa 2162761 aagcaaaagg cctctgtggt tttctatgta gatatgaagt ctgccaacca ttgtaatcct 2162821 cggcagatcc atcataacgt ccgggggaat ttccaatgct cttgtcagcc aagctttcat 2162881 acgattcttt ctttgcccca tacaaaaaga accccctttc atctcatatg tatgatttga 2162941 aaggaggttc taacacttta atttttacgg gccgggcgca tcgtacggtg aggttttttc 2163001 gcccgtggag gtccgaacac ctctcctaga acgatcccct gtacgacggt gtctttattc 2163061 acctgaagca ttttttgttt tgtgtatact gttttttgtt tggcagcagc aagatctcgt 2163121 tccagccctt tcaggtttct tgctgtttcc ctgcgtcttt cttccgcttc ccgtcttgcc 2163181 tgttccatac ggttagggat aggtgcaggg gcatcttctt ttgactgctt cttttgagga 2163241 gaagcagatt gcacgtgttg aggttttttt cttttttggc tgttttgctt ttcttctttg 2163301 ctctttttgc cgaaaatcgc agaaatgatt ccgatgatcg ctgcaataat aagcggattg 2163361 gtcagtaaat cttccatcag cgttctccct tcttagagag attatgattt gcggtcttca 2163421 tccgaagggt ctttcgtcag cttgccgaat gaatcacgca tttctgtgtc agcatcgatg 2163481 ttcttgatat tcatgtaatc catgacgcca atattccctt cacgcaaagc ttctgccatc 2163541 gcaagcggca cttccgcctc ggcttctact actttcgcgc gcatttcttc tacgcgggca 2163601 cgcatttcct gttcttgagc gacagccatc gcacgtcgtt cttccgcttt tgcctgcgcg 2163661 atgtttttat cagcctcggc ctgatcggtt tgtaaaattg ccccgatgtt tttgccgata 2163721 tctacatctg caatatcaat tgagagaatt tcaaacgcag ttcctgagtc caatcctttt 2163781 ccaaggactg tctgagaaat catgtcaggg ttttcaagca cttttttatg attatcagat 2163841 gaaccgattg tagaaacgat tccctcacct acacgagcta caatggtttc ttcccctgct 2163901 cccccgacga ggcgctcgat attcgctctt actgtgattc tcgctttcgc tttcacttca 2163961 atcccgtcca ttgcgacgcc ggcaatgaac ggtgtttcaa tcaccttagg attaacgctc 2164021 atttgaacag cttccaacac gtcccggcct gcaagatcaa tggcagcaca gcgctcgaat 2164081 gtgagttcaa tgttagctcg ctgagcggcg ataagcgcgt tgacgactct gtcaacatta 2164141 cctccagcca gatagtggct ttcaagctgg tttgttccaa cattaagtcc cgctttatgc 2164201 gctttaatca gcgggttaac aacccgattc ggaatgacgc ggcgaagcct catcccaact 2164261 agagtgaaaa tgctgatttt cactccggct gccaaagctg aaatccaaag cattacaggc 2164321 acaaatgtaa aaaatactgc caaaacaatg atcgctactg cgacaattgc cagaatcata 2164381 agtgttgacg gatccatata acttctcctc gtttctattt aaatttctct cacgacaatg 2164441 cgtgagcctt ctacttttat cacttttact tttttatctt tttctgtaaa cgatccctcc 2164501 gatacaacgt caaggcgttc atcatcaata atcacggtac cggaaggacg cagcggtgta 2164561 aaggttatac ccacttttcc cattaagtcc gtgcgcgttt gatttgaaac gtagccgctc 2164621 tccgtgtttg tagaatcatt taatatcaat ttcttaaaga atttcatacg ctttcccaac 2164681 acccttgtca gtaaaataaa agctgtaatc gaaacagctg aggcgatcaa gagagaaacc 2164741 gccatgacag tgaagctccc cgcggctaaa aacaggctcg caataatcgc tcccaagccc 2164801 agtaatccaa tgattcctcc gggaagaaaa atctcaagca gaatgagaat cacccctgct 2164861 ataaagagga gaaccgtctc atacccggca aggccggctg caagatgccc gtaaaagaac 2164921 agcaataacg caatgagtcc agccgttcca gggaggccga cacccgggga aaaaagctct 2164981 accgtcagac ctaaaaaagc gattgtcagc agaataggga caatgaccgg attcgtcagc 2165041 catcttgccg tcttttccgc aaagctctcc tttgcatagc tgatctgcgc cttttcgaac 2165101 ccaagcttct ttacgagcgt ggacaaattg tcagcagtgc cttctgaata gcctacctca 2165161 atcgccttgt ctgcgttaag tgtcagcaga tctcccttag gcgcgccaac ttccttggca 2165221 tctatatctg ggtcagccat tgcgagcgca tattttggat cgcggttatt tttcactgcg 2165281 gcatcttcca tctctgccag ccaaagtgat tgagcttttt ggtcagcggc attgccttgg 2165341 ccatcaacaa tcgcggcggc tcccattttt ccgccaggcg ccatataaat gtgatctgct 2165401 tgaagtgcaa tatatgcacc agcagacaac gcgcgtttgt tgacatatgc agttacgggg 2165461 atctcgcttt cggttatcaa atcggccata tcaatagcag atttgaccaa tccccccggg 2165521 gtattgatat caagaataat atggtctgca tgtgcatcct ttgcgtcttg taacgaacgg 2165581 gacaaaaacg aggcgagacc ctgttcgaca tttttttcaa ccgggatcac ataaacagtt 2165641 tgtttttctg cttttgcgtt cagctgtacg cctaataaag aaagtaaaaa tatacccaaa 2165701 agagcagcac ggaatccttt gatttgaagc aagggcggtg tatccctcct tccttttata 2165761 ataagtgcct tctcttcata cgtaacaaat gtatcaaagg tttcattttt ttatgtataa 2165821 aaaaagacat ctctcttaga aagatgtcct tttctttgcc atttaagaca gttgactgct 2165881 cacaagctta ttaattaaac ttccgtcagc tttacctttt actttaggca taattgcccc 2165941 catcactttg cccatgtccg cttttgagct cgcaccgacc tccgcgatgg tttcatttac 2166001 gattgtacgc agctcttctt ctgacagctg ctcaggtaaa taaacttcta aaatgtccag 2166061 ctctttttga actttatcta ctaaatctaa acgattagcg tttgaaaatt cctggaggga 2166121 gtctttacgt tgcttaagtt cacgagaaag gacagtgagt tcctcatcct cggtcaaact 2166181 gtctttctta agcttaattg cttcattttg aagtgaagcc ttaaccattc gaacgacagt 2166241 cagtttgtct ttctcacggt ttttcatata cagcttcata tcctggttga gacgctcaag 2166301 aagactcata aatccaccct cttttagaat ttgcgttttc tagcagcttc agactttttc 2166361 ttgcgcttta cgctaggttt ttcataaaat tcacgctttc ttgcttcttg caaagtacct 2166421 gtctttgata cactgcgttt gaagcgacga agagcatctt caagcgattc gttttttcta 2166481 acgaccgttt ttgacattct ctttccctcc ctccgaatac accaatcgac tacctttaag 2166541 ttacacatat aaacatgtac tttgacatta taatataagc catcagtcag gtcaactaag 2166601 tgagttcact tttccgtcat gagtgcgact gcctgtctat ataatgaaag aaaggggttg 2166661 gtgaatagga tgttaattct gattagcttt actgctctta tattattctt tctcgcaggc 2166721 atgaacatgc ttcgaaaggg cttaatttca atggcgtact caaaaattga agaacgtttg 2166781 cttttattta cagaccatcc gttaaaagcg tttcttatca gtattgtatt tacggggata 2166841 cttcagagca gctcagcctt tatggtcatt gtcatcggct ttgtaagtgc gggcgttctt 2166901 tcttttaagc ggacgatccc gatgattctg gggacaaatg ttggctctac ttttacaact 2166961 gaatttattg ctatcaaaat ggatattgtg atttgggttc ttttaatagg aggtttattg 2167021 ttttttctga ctggcaggta tcctttgaaa cagctgggaa caagcttcct tggactgggc 2167081 atcatcttct tttgcatcag cggattcagc catcttgccg ggccgctgac aaagctgaaa 2167141 acgggcgccg acgttctata ccatgttaac gattcaaact ggtccgcttt gctcatcggc 2167201 atggtgttaa ctgccatcat tcactccagt tctgtctgta tcggcatttt gatgagtttt 2167261 atgaatgaag ggattatcgg actgacacag gcgatgagcg tcgtactcgg atcaaatatc 2167321 gggacatgca ttacagctgt catggctgct gtatccggcg gatatgcggc gaaacagaca 2167381 gcatatgccc atgtggtatt taacgtgcta ggggtggctc tagtattgcc ttttctgacc 2167441 gcagcgaccg gctttgtaga gcagttatca cctgatcccg cacaaaagat cgcgcatttc 2167501 agccttttat ttaatgtggt gacagctctt ttatttcttc cgcttacaaa cttgttttac 2167561 cgattgattc accttcttat cccggctaaa taaaaaaatc ggtacatttt aatgcaccga 2167621 ttttttaggt taagaagaca aacgcatgtg ttcagttatt tcatcctcaa ccacacggac 2167681 aaactgtcct tcgttgtaag gataacctgc ttttaggatt ttgactttta cgattttgcc 2167741 gatcatatct tccgtacctt tgaaaacaac cttcatataa ttgtctgtgt aaccgacaaa 2167801 catattttct tcttctgttt ccttaaacgc ttcctcaggg ataatctcaa gcacttcatt 2167861 ttcatactga gaagcgtatt cttttgcaag ctggtcagaa agagcaatca ggcggtgcac 2167921 acgttcgttt ttcacgtttt catccacttg gtcttccatt cgtgcagctg gtgttcctgt 2167981 acgcttactg taagggaaaa catgcagctc agagaattta tgttctttaa taaagttata 2168041 ggtttccata aattcttctt ctgtttctcc agggaacccg acgatgacat cagaagtaac 2168101 agctaagcct ggcagtgctt ttttcaattt atttaaacgg tctgcaaaga attccattgt 2168161 atatttgcgt ctcatccgtt taagcactgt gtttgatccg gattggatag gaatatgcaa 2168221 atgattcact atcttatctg agcggtctaa gacctcgatc acttcgtcag tgatttggct 2168281 ggcttcgatt gaagaaattc tgatccgttt cacgccttcc acacgggtgt ctaattcgct 2168341 caaaagcttc gcgaagttgt aatctttcat atcttcgccg tagccgcctg tatgaatacc 2168401 cgtaagaaca atttccttat atccggcatc gacaagctgc tgcgcttgtt taatgacttc 2168461 ttcagggtcg cgggagcgga gcaggcctct cgcccacgga atgatacaga atgtgcagaa 2168521 attattgcag ccctcctgta ttttcaatga cgctcttgtg cggtccgtga aagcaggcac 2168581 atcaagctct tcatatactc ttgctttcat gatgttgctg acgccattaa tcggctggcg 2168641 ttcttctcgg tattggtcaa tgtagccaag cattttttca cggtcctgtg ttccgactac 2168701 aatgtcgaca ccggggatcg ccataatctc agcaggtgag gtttgcgcgt agcagcctgt 2168761 gacacagatg acaccgtcag gattttgacg aatggcgcgt ctgatcactt ggcggctttt 2168821 tttatctccc gtatttgtaa ccgtacatgt attaatgaca tatacatcag ctgtttgttc 2168881 aaagtctctt ctttcatagc ccgcttcttt gaaaagctgc cagattgctt ctgtttcata 2168941 atggttgact ttacagccaa gcgtatggaa agcaacagtt gccattactg atcacctctt 2169001 aataactctg tttgataaga aatcgcactc aacgcgtata gcggagcggt ttctgtcctt 2169061 aaaattctcg gtccaaggcc gcacgtcaca ccgtcttgct ctgtgagccg ttcaacctcc 2169121 gcttctgtta aaccgccttc gggaccaaat acgatcaata gagatgatcc tttcggaagg 2169181 ctgcttacaa tcgcgctgaa tgcgcttatt tccccttgct tcgatgactc ctcgtatgca 2169241 acgacacatt tatcgaaatc ctgcatcctt tgaagaagct gctgaaaaga atggacatcc 2169301 atcactcgcg gcacttcgtt acggtacgat tgctcagccg cttccttcgc aattttcgtc 2169361 catctttccc gctttttctt tgcctttttg tcatccagct tgacaacaga acgcgcggct 2169421 tggaaaggaa taaaggcatg agctccgagc tcagtcccct tttggataat ccattcaagc 2169481 ttatctcctt tcggaaggcc gctcgcaata tagaccttta tcggaagctc tctgttttca 2169541 ttcgtccatt ctatcacaag gcaggacact ttatctttgg aaacagattg aagttcacat 2169601 tttgcctcga agccgtcttg agagcagcag ataatctgat ctccctcatt cattctcatc 2169661 acgttcacaa tatgatgaac ttcttcgccg gtaatcgaaa aagtcggcgc ttcctctatt 2169721 tgctgcttcg tgagctcgat aaaatatcgt tgcatacgct gtgacaccta ctaactgtta 2169781 ttttttcgca ataatgctga cccaatcttc cattgaaagg atttctacaa tggtaaagcc 2169841 agcttgttcc agtgcttctt ttacttcttg ttttttatga ccgatgattc ctgacgtaat 2169901 aaagtgaccg ccttctttta acaggctgta cgcttgtgaa gtaaagcgaa gaatgacttc 2169961 agccaaaatg ttggccacaa tcacatcatg ttccccttca atcccgtcta acaaattgtt 2170021 ttgcttcact tgagcaatat cgctgacttt gttcagcttg agattgaggc gtgcactttc 2170081 tacagccacg ggatcaagat cgtaggcatg aaccgattca gcctcaagca ttgcagccgc 2170141 aatacttaaa attcccgaac cagtgccgac atcaatcacc ttatcaccct tttgcacaaa 2170201 gcgttcaagc gcctgaatgc agagtacggt tgtcggatgt gtccctgtgc cgaaagccat 2170261 tcccgggtcc atttcaataa tcagttcatc agtatggacc ggcgtatatt cctcccacgt 2170321 cggcacaatt gtaaactttt cagaaatttt cacaggatga taatactttt tccaggcagt 2170381 cgcccactct tcttcattta cttcagaaat agtgatgtgg tttctgccca aatcaatatt 2170441 gtaaagaagg agattattaa tcgtttcttt gatgccgtct acagtttcgc ccagaaaact 2170501 gttaaccggc agatatgctt tgacaatgac accctcatct gggtaatcat tggggtcgag 2170561 ctggtagatt tccccgtaca cattctcacg ttctttaatt aaatcaagcg ggtcctctat 2170621 cacaacccca cttgcaccag cttcatgcaa tatatttgag ataggttcga ccgcttcatg 2170681 tgttgtgtga atgcttaatt cggaccattt caaaactacc aactcctcat ccaataatta 2170741 atcgccttta aacgcgcgtt ttaccttgtc aaagaaactc atttcctgtt cgtcaggcag 2170801 gtttccgctg acttcggcaa attcgcggat aatgtctttt tgtttatcag tcagatttgt 2170861 cggcgtaacg acgcggacga cgatatgctg gtcaccctgt ccatagcctc tgacattttg 2170921 aacgcctttg cctcttaatc tgaatttcgt tcctgtttgt gtaccggccg gaattttcaa 2170981 tttcactttt ccatgcagcg tcggcacttc tacctcatct ccaagagcag cctgagcaaa 2171041 cgttaacggc atttcacagt aaatatcatc gccgtcacgc tcgaagaact cgtgtgcgcg 2171101 tacatggaac acgacaaata aatccccggc agggccgccg tttattcctg gttcaccctg 2171161 tcccgagaga cgaagctgct gcccgtcatc tacaccggct ggaattgtca cattgatttt 2171221 cttgcgtttt ttgatttttc ctttgccgcc gcagtccgca catttgtttt taatgatttt 2171281 gcctgtacct tcacagtggt ggcagacccg tctgttaacg acttttccaa acggtgtatt 2171341 ttgctccacg tttaactggc cggagcctcc gcagtgggag catgtttctg gatttgttcc 2171401 aggtttcgca cctgagcctt tacatgtttc gcacgtttcc tcgcggggaa tttcgatggt 2171461 tgtttcttta ccgaaagccg catcctcaaa cgacagggtc atcgtatact gtaaatcagc 2171521 accctggcgc ggagcgtttg gatctcttcg tcttgtgcct ccgccgaata tacttgagaa 2171581 aatatcatcg aaaccaaaac cgccgaaatc gccgccgcca aaacctccgc cgccgaagcc 2171641 ttggttaggg tcagtgtgac caaattgatc gtaatgcgca cgtttttggt catctgacag 2171701 cgtttcgtat gcttctttta cctctttaaa tttttcatct gatccggctt ctttgttaat 2171761 atcaggatga tatttttttg acagcttccg ataagctttt ttaatttcat cctttgaagc 2171821 gctcttactt actcccagca cttcatagta atcacgctta ctcatctcgc ttcactctcc 2171881 cgaatttctc acataaatta gattgtatca ttttgaatta tgatttttca attcctttta 2171941 tcccgggcaa gaaaaaaagt caaagccaag agatgcctga ctttgacttt ctaatcattg 2172001 aatcagatta tgaaatgtgt tcttttcggt cagctccgga agcggggctg acactaaaaa 2172061 gaacttattt tttgttttgg tcgtcgttta cttcttcgta ttcagcgtcg acaacgttgt 2172121 catccgcttt gccttcagcg tttgctccgc cttgagcttg ctgtgcttta gcagcttctt 2172181 cataaagctt catagaaagc tcttgaacga ttgtttgaag ctcatctttt ttcgctttga 2172241 tctcttcaaa ttcgtttttc tcaatcgctg cttttaaagc gtctttggca tcgttggctt 2172301 ttttcacttg ttcttcgtcc actttgcctt caagatcttt taatgttttc tcagtttgga 2172361 aaacaagctg atctgcttcg ttgcggactt cgatttcttc ttttttcttc gcatcagcgt 2172421 cagcattttc ttccgcttct tttaccatgc gttcgatctc ttcatctgag agacctgaag 2172481 aagatttgat tgtaatgttt tgttcttttc ctgtgcctaa gtcttttgct cttacgttta 2172541 cgataccgtt tttgtcaata tcgaaagaaa cttcgatttg aggcacgccg cgcggtgctg 2172601 gcgggatatc agtaagctgg aagcggccga gtgttttgtt gtcggcagac attgggcgct 2172661 caccttgaag aacatggata tcaacagctg tttggttatc agcagcagtt gagaacactt 2172721 gagatttgct tgttgggatc gtcgtgttgc ggtcgatcag ttttgtaaac acaccgccca 2172781 ttgtttcgat accgagagaa agcggtgtaa cgtcaagaag aacaacatct tttacgtcac 2172841 ctgtgataac gccgccctga atcgcagcac caagcgctac aacttcatcc gggtttacgc 2172901 ctttatgcgc ttcttttcca gtttcttttt tgattgcttc ttgtacggca gggatacgag 2172961 ttgatccgcc gacaaggatg actttgtcga tttcgcttgc agaaagtcct gcatcttgaa 2173021 gcgcttgacg gacaggaccc attgtgcgct ctactaaatg agaagaaagc tcttcgaatt 2173081 tagcgcgagt taatgtaagt tcaaggtgaa gcggtcctgc ttctccagct gtgataaacg 2173141 gtaaagaaat ttgcgtagaa gatacgccgg aaagatcttt tttcgctttt tcagctgcgt 2173201 ctttcaaacg ctgaagcgcc attttgtctt ttgacaaatc aatgccgttt tcttttttga 2173261 attcagacac cagatgatcg atgataactt ggtcaaaatc gtccccaccc agacggttgt 2173321 cgccggcagt tgaacgaact tcgaatacac cgtcgccaag ctcaaggatg gaaacgtcga 2173381 atgtaccgcc gccaaggtcg tatactagga tcgtttgatc ttcatctgtt ttatcaagtc 2173441 cgtatgcaag cgctgctgca gtcggctcgt tgatgatacg ttctacttca agacctgcaa 2173501 ttttaccagc gtcttttgtt gcttgacgct cagcatcgtt aaagtatgca ggaactgtga 2173561 taactgcttt tgatactgtt tcgccaagat agctttcagc gtatgattta aggtgttgaa 2173621 ggatgatagc agacacttct tgtggagtgt aatcctttcc ttcaatttca actttataat 2173681 cagtacccat atgacgtttg atagacataa ttgtgttagg gtttgtaata gattggcgtt 2173741 tagccacttc ccctacttga cgttcgccgt ttttaaatgc aacaactgat ggcgttgtgc 2173801 ggtttccttc agcgttagca ataactttag gctcgccgcc ttcaagcact gccacacatg 2173861 agtttgttgt tcctaagtcg attccgataa ctttactcac ttgaataacc tcctgctatg 2173921 taattattga ttcactttga ccatggaagg gcgaatgacg cgatccttca gcttatagcc 2173981 tttttgcatt tcctcaacaa caatgttgga gccgtagttt tcgtcttcag cctgcataac 2174041 agcttggtgc agattaggat caaattcctg ccctacagct tcgatggctt cgacgccttc 2174101 ttttttcaag gcttctacga gctgacggtg gaccatttcc attccctgga gcaaactttt 2174161 cgtctgttca ttgtcggctt caacctgaag cgctcgttca aaactgtcaa gagccggcag 2174221 caaatcagtc acgatatttt gagaacggta tttttgggac gcttccatct ctaaacggct 2174281 gcgtcgttta tagttttcaa agtctgcttg aacacgcaaa agtttgtttt ctttttcctc 2174341 aagcaaacct tgcaattcgt taatttggtt ttgaagaagt tcgctttcat ttgtttcttc 2174401 ctgctgttca tcagcggcag cttgttcttc aatgatttct tgctcttctg tttcgttttg 2174461 ttcaacggtt tgtttttctt ctgacattgt gttcacctcc ctcaaagtgt aaggagaagg 2174521 acaggtgctg cccttcgata aaatttgcca aaattccctt attcatcata cagacttgtt 2174581 aatgcttttg acaagtccga agtcacatgc tgaagcaggc tgacaaccct ggaataattc 2174641 atgcgggtcg ggccgataat cgcaattgag ccgatctgct tctggtctac ggaataagaa 2174701 gccgtaatca gactgcaatt ttccatctct tcatagtcgt tttcttttcc gattttaatc 2174761 gaaattcccg tgtgcgggga ttgaaccagc tttaaaacat cctgttcttt ctcaattaat 2174821 gaaagcagcg accgaactcg ggtgatatca tggaactcag gctggttcag catattgatt 2174881 ttcccgccaa aaaacaactt ttcaacgtga tttgtggaat gaaaggttga acgaagcgcg 2174941 tcgagtatat tgtcatagtt tttaatgtgc tgtcttaggt acatgacaac ttctttaaat 2175001 atgcgctcat tcagttcatc cattggaacg ccgcttaaac ggtcgttcag tatatttacc 2175061 agtttttcaa tatcagacag atccattttg gtcggaaagt taatcgtttt gttttccaca 2175121 tgccccgtat tggtaacgag aatcgctacc gccatatcag gctgaatcgg aatgatttga 2175181 atctgtttaa ggtaattctc actcaacttc ggcccgagta cgatggatgt gtaattcgtc 2175241 agatcggaca aaatttgcgc tgatttttga actgtcttct ccagctcgaa aattttctct 2175301 ttgaagatcg agtggatttg gtccaggtcg cttttcgtca atttgacggg tgacagcaaa 2175361 tggtcaacat agtaccgata ccctttttct gacggaacac gtcctgagga tgaatgggtt 2175421 ttttcaataa agcccaattc ctccaagtca gccatctcgt ttcttattgt tgcagagcta 2175481 aatgtgattt catctttttt cgaaagagtt cttgatccca ccggctgtgc cgatttaata 2175541 aaatcgttga ttataacctg aaggatcagc agctgacgat ttgttaacat catcatcacc 2175601 tctgttagca ctctcaataa gcgagtgcta attctataac aaaagtatca aaccacaaga 2175661 aaaatgtcaa ttataactca cccaaaaaag cgccaaaaac ttcattgcct aataatttcc 2175721 cttgatgagt caaataaacg gcagactccg aattgtgaat cagccctttt tcagcgaggt 2175781 cttttaacac gcttgggaaa agtccatcca gggaacggcc gtatttttct gcgaatcgtt 2175841 ttttgctgac accggctgtt tttctcaaac ctaaaaacat ttcttcctca atctgttctt 2175901 ctgttgtcac ttcatgtgta tctctgtacg gaaaaccctt ttcagctatc aggtcaatgt 2175961 aatgcttaac aggtccgacg ttcactgttc gtgtgccgcc aatatatccg tgagcgccag 2176021 ctccgaaacc gaaatattgt tcgttgctcc aatacgttag attgtgctta gattccatgc 2176081 ctgccttagc aaagttgctg atttcatatt gatgaatgcc gtgagcttcc atcttgctca 2176141 tcactatttc atacatttca gcttcctgct cctgcggcgg aagatgaagc cgcccttttt 2176201 gcatcaaatt ataaaatacc gttttcggtt ctacaataag ggagtaaacg gaataatgct 2176261 cagcgtccaa tgataaagca gtgtttatgg aatgttccag atgcttgagg gtttgccccg 2176321 gaagcccgaa catgagatca agactgatat tctcaaaacc gatttcccgc gctctttcaa 2176381 aagaggtgaa tacatctttt tgcttgtgca ctcggccgat tttttctaac agatcgtctt 2176441 cgaacgtttg cacaccaaag ctaaggcgat ttacgcctgc ttcttttaat atttttaatt 2176501 tctctgcgga caaatcgtcc ggattcgctt caaccgcaaa ttccgataag tcgcttgagg 2176561 gctttagcac gcggttgatc atatccatca gctttttaag ctgttcctca gacagggagg 2176621 tcggcgtgcc tcctccgata aagattgttt tgagatcagg ctgcccggtt tttgctattg 2176681 tatttatcat ttcctgttcg agtgcgttta aatactcgtc gactggctga ctttgaataa 2176741 aatatttatt gaaatcgcag tagtggcaaa tatgctcaca aaatgggata tggatataag 2176801 ctgatttcaa cggattcacc ttctttacag aaagaagccg cagtacaaga ctgcggcggc 2176861 ttctattgtt ttttcggact gtcgtccatt ttcagaactg ccataaatgc ttcttgcggc 2176921 acttcaactg agccgacctg cttcatacgg cgctttcctt ctttttgttt ttcaagaagt 2176981 ttccgtttac gcgagatgtc ccctccgtaa catttagcca atacgttttt acgcattgct 2177041 tttatggtgg agcgggccac gattttctgg ccgattgcgg cttgtaccgg aacttcaaac 2177101 tgctggcgcg gaatgagttc tttcagtttt tcaacgatca cttttccccg ttcatatgcg 2177161 taatcacgat gcacgataaa ggaaagggca tcgatttttt caccattcag cataatgtcc 2177221 attttcacaa gcttggacgg tttgtagccg atcagttcat aatcaaagga cgcatagcct 2177281 ttagtgcttg atttcagctg atcaaaaaac tcatatacga tttccgctaa tggcatatca 2177341 taaatgatgc tgacacggtt tgcgtctaaa tactgcatat caatgaaatt gccgcgtttt 2177401 ccttggcaaa gctccattac agcgccgaca tagtcattcg gcaccatcat cgtcgctttt 2177461 acgtatggct cctcaaccct ttcgatcttt tgaggatccg gcatgttgga cgggttgtcg 2177521 acaacgacct tttcgccgtc tgtcatatac acgtcataga taacgcttgg cgctgtcgta 2177581 atcaggtcga tgttgaactc acgctcaatt cgctcctgaa tgatctccat gtgaagcatg 2177641 cctaaaaatc cgcagcggaa cccgaatcca agcgcttgcg aagtttccgc ttcatattga 2177701 agggaggaat cattcagctc aagcttttca agagcttccc ttaaatcatt atacttcgct 2177761 gtatcaatcg gatacaaacc acagtacacc atcgggttta gcttgcggta tcccggcagc 2177821 gcttcttctg caggattggc agcgctcgtt attgtatcac cgacacgtgt gtcaccaaca 2177881 tttttgattg aggcagtcag gaagcctaca tcaccgaccg tcagttcatt tgtcggagtt 2177941 gctttcggcg tgaacacgcc cacctctgtt acttcgaatt ctttgccggt tgccatcatt 2178001 ttgatttttt gtcccggctt taccgttcct tcaacgactc tgatataagc cacgacaccg 2178061 cggtaggcgt cataaagcga gtcgaagatc agcgctttga gcggcgcctc cggatctccg 2178121 gtcggagctg gcaccttttc tacgatttgt tctaaaatct cctcaatccc gataccggct 2178181 tttgctgaag caagcacggc ttctgatgcg tcaaggccga taacgtcttc tacctcttgg 2178241 cgcacacgtt cgggctcggc gctcggaagg tcgattttat tgatgaccgg aaggatttca 2178301 agatcgttgt caagcgctaa gtagacattg gcgagcgtct gcgcttcaat cccctgggct 2178361 gcatccacga caagaatcgc tccctcgcag gcagcaaggc ttcgggatac ttcatacgtg 2178421 aagtcgacgt gtcccggcgt atcgattaga tgaaagatat attcttctcc gtcttttgct 2178481 ttatatttaa gctgaacaga gtttaattta atggttatgc cccgctcacg ttcaagatcc 2178541 atagaatcga gcaattgttc tttcatttct cgttgagtga ttgccgacgt tttttctaaa 2178601 atacgatccg ctaaggtcga ttttccgtgg tcaatatggg caatgataga gaaattccgt 2178661 attctcgatt gcctctctaa acgcttttct ttatctgtca caatctatca ctcctactat 2178721 taaacgcaaa atacactagc ttagattata tcaataggat tgtaaagatt caatgtaaaa 2178781 caagaaagag aaaagttccc tatcatatct gggttgcttt tctctttcac gtacttattg 2178841 attcatatcc cgtatccatt catacattga ctgggcagta ttggttacgg tgtccgaaag 2178901 cgcttttccg gcttttgaaa acatattgaa tgtctccacc ttttccagct ctttttgttt 2178961 ttctactaaa tcttttgccg tgactgtttc tcctaggatt gaggcttctt tttcattatc 2179021 ttttccgtcg gtgagcgtaa acgccccctt cagtgaaggg tcatgatagc ctttcatact 2179081 cagcatcccg tggtttgcct gctgcatgcc gaacagaacg cctaaaaaca tgatcgtgac 2179141 aagcagtaag cactttccaa agtatgcaat caaatcaacc acctatttct tattgttttt 2179201 tcgtctcccc gctcgctgcg ttgacctttt cagcatccca gtacatttcg ctgaatacgt 2179261 ccgcggccgc gttagccgca cgctgcagct cttcgagatt attatccact ccgccaaact 2179321 cgagcaaaag cgctctatcg gttaaatcct gattgtaaac accattatcg cctggcgagc 2179381 ctttggaaaa gacacctgtg ctaagtccgg ggtatttttt ctccatcagt ttatgaagct 2179441 cactcgcaat tttatagttt tcttcgaagt ttttgctttt tttcccgacg acaaaggcta 2179501 ccctggcata gcttttccct ttaatcgttg cggttgtgtc ttttttgcgc cgagagtctc 2179561 tgtggatgtc aatgatatat tgcagatttt tgtttgaagc gagggcgtct ttcacgaccg 2179621 gccttgattc atcataggac ctggcatagt ttaagccttt tttattcaat tttgactgta 2179681 tatcggtttt attcactgtg gctccgattc cctgggattc aagcgcttgt ccgaacatat 2179741 ctcctacaag cgtgacattg gctttagaat ggcgcgccat gtcaggatcg gtctcgcctt 2179801 ttaatagagg gagatatgat tccgtattgt gcgtgtgata gataaacacg acctttttat 2179861 cacctgttgt ttgtttcggc ggatcttttt gcgcattatc tgattgcgtt tgctgttttt 2179921 caatctctgc caaattcgct tctctttctt cctccatcac cttagacggc ggcggcgatt 2179981 ccgcaggcat attcgtataa tccgttcctt gtccagctaa caaaatctcg gtatcaaatt 2180041 gtgcaaatcc tggcagctcc cgaccgagaa agctccgcgg atcttcgagg ttaatgctcg 2180101 tcgccagctt taaagaaaga cgagaaagat gaaatgagct gtctgtttga gagaggtcag 2180161 aagcgaaata atggttttcc atctgcagca aatgtgcaaa tacgtcaccc ggcaattctt 2180221 cagcaatccc ataaaaagag tcagacgacg gcctaagttc cggccggaga gacgtcagca 2180281 caccggatag aacaaaaatc acgataaggc ttacgataaa tagaaagatg gcttttaccg 2180341 ctttccctcc atttaccgca acaacaatct gtctgtttct gcgtttattt ctcattgaat 2180401 ccctccagcg cttgtctagt aattactcta tgaacaagct agaggaagta gaactgttta 2180461 gtgattgtag gagcctttgt tttcttgtga cactttttca tgaagcgctg tgtttaatcc 2180521 gttcgctaaa acatttgcca tatcgtcgat aaatgaatcg acttccttcg gtgtaaccat 2180581 taagttgtgc cctaaaggcg aaagcacctc gtgaatgagc tgccgttttt catcttcttg 2180641 aagggttccg acaataccta ggaacgattg gcgctgcttt tgatcgggaa gatcgtcttc 2180701 agtgagcact ttctttttcc caaacgtcat gcctgccgga acaagcgatc ttgatggcct 2180761 gttatccttc atttctctgc caaaatgttt taatatgtag tccaccgtgt cgctggcaat 2180821 tgtcacggca tcaactactg tcggaacacc gatagcaatc accggaacac caagcgtgtc 2180881 tttgcttaaa tcttttcgtt tattccccac tccagacccc gggtgaatgc ctgtatccga 2180941 tatttgaatg gttgtgttga ccctttccac cgcccgcgcc gccaacgcat caatggcgat 2181001 gacaaaatca ggcttcgatt gctcaatcac acctttaata atgtcacttg tttcgattcc 2181061 tgttatcccc attacacccg gtgcaaaagc actgacaggc ctgtaaccct cctgtacgtt 2181121 ttccggctga agcttaaaca agtgccttgt taccaacaga ttttctactg ccatcggtcc 2181181 aagcgcatca ggtgtcacgt tccagttgcc gagcccaacg atcaaacagc tcgcatcttt 2181241 tgagatatta aggttttcaa gaaaagctga gaattcctcc gcaaagacag cagagacctt 2181301 ctcctgcatt tccgaatcat tctccctgat tccctgtgct tcaagcgtta aatagcgccc 2181361 ttcttttttt cccgaaagct ctgcgccttc ctttgtaaca tcaactgtgc ggattttaat 2181421 gccgccgtga tcacgctctt tttcaataaa gcctttaatt tcttttgtcg gcacagcctg 2181481 ctgattggcc attgcttcct tcgtttccac tgccaaatcg gtccgtatca aatactgatt 2181541 cacatccagc tcactctttt tcatacaggg gcctccttca cattaagtac ctatattgtt 2181601 gccatttgct gaataaatca tgctaaaaag agaaccttca atgaaaaata ctttacattt 2181661 atattgcaat ctaaaggtgt gtttgataga atacaatttg ttctattgtg aagaagattt 2181721 aaccttaaga cactgtgcta caggttgtat cttaggaggt gaaacacatg ccaaacatta 2181781 aatcagcgat taaacgtaca aaaacaaaca acgaacgccg cgttcataac gcgacaatca 2181841 aatctgctat gcgtactgca atcaaacaag ttgaagcttc tgttgccaac aacgaagctg 2181901 acaaagcgaa aactgctctt actgaagcag ctaaacgtat tgataaagca gtgaaaacag 2181961 gtcttgtaca caaaaatacc gcagctcgat acaaatcaag actagcgaaa aaagtgaacg 2182021 gactttctgc ataatataaa aacgatcctc aataatgggg atcgtttttt tcatttcttt 2182081 ttaacagctg taaaaggaac agttcgagca ggagctgctt gtcctttttc ccggttttca 2182141 tctcatagtc catgacggca agctgttcaa taattaaacg gagctcctcc tctgaaaaaa 2182201 gccttgcttg atccatcgcc agctttaccc gaaatgggtg aacttttaga ttagaagcga 2182261 tttgtttttg tccgtatccc tgttccgcga agtacttcgt ctgcagaatc agccggaact 2182321 gattcgaaat aagcgccata attttgatcg gttcttcatt ttgttttagc aaatcataaa 2182381 aaatttgcag actctctgtt cgttttcggt tgacgatttt attgatcagc tcaaaaatat 2182441 tttgttcaag gcttctagca acaagcattt ttacatcatc cagcgtaatt tcttcacgat 2182501 ctccaataaa cgtgcagagc ttttgaatct cctgaaaaat cgatgacaga tgaccgttca 2182561 caagcagaac caaatgctcc gccgcttccg tgccgattgt tttctgctct gtttttgcaa 2182621 ggttgacagt aaagtctgtc gtttcctttg catttaattc cttcgcctcc atcataaacg 2182681 cgtgcttctt taacgctttc gtcagctttt ttcgctcatc aagcttttca tacggagcaa 2182741 gcaggacaaa gactgtgtaa ggcgcaggtg attgtatata tgattcaagc gcactgacgt 2182801 tgtgctcaat tttttctttt ttcttttcac ctgttaaaaa atatggattt ttcacaatga 2182861 caagacgccg ctcccccata aacggaaacg tttcagcatc tgcaatcgct tgatccagcg 2182921 ggtcctcttc cagatcaaaa acggacagat tgaaatcctt tgtctcctga tcaacgaccg 2182981 tctgtctgat cctgctgacg gtttcttgca gcagatatgt ctcttttccg tataaacaat 2183041 aaaccggatg gacctctcct tttttcaggc ttttccacac atcaaatacc attgttgtac 2183101 gacttcctct ctttcatcat ccccttctat cctaaattga gtttgcaaaa tagtaaagag 2183161 gaagcctgac tgctgcttcc ccatttatat taaacgcctg ttcgcaagcc cccgggacag 2183221 cttgtaaaaa ggcgataatc accagaacag aaaacgttac cttagcttct agatttttca 2183281 aaacaattcc attatactta agtcagtcag gagggataaa gttgaatgat tttgaaaaaa 2183341 acgttcaaag caaacgaaat gatgctgtag attcagctgt tggttttgtt gtgtccttcg 2183401 gatttttcgc cttcttgttt gtcatggcaa cggttattca cctagttggt tcataacagc 2183461 gactgcccgg gctgctgatt tctcggcagt cttttttagt tcgtctctgt tatatctgat 2183521 gtatcatatg gaggatagac agaaaaggtt ccaactctgt ttttgtatct atattggatc 2183581 gttccgtttt gatctgttcg cagcacgcgg atagaatgtc tctgtaatag ttgcagaact 2183641 ttttgatgag gatgatggta ccgattgttt ttcccggctg agataatggc cgttttcggc 2183701 tgaagctgtt ggatgaattc ttcaccggta gagcctttgc tcccatggtg ccccaccttt 2183761 aacacatctg cttttatatt cggaaacacg ttcatcacct cttgttcccc ttctttctcc 2183821 agatcacccg tcaagatcca gctcataccg cccgtctcca tccacagaac gagagatgaa 2183881 ttatttttgc ttgccggatc aggtgcttcc ggtgacagta catggaactg caaatccttt 2183941 atttgcaaca catcgcctcg cttcacctct tcaattgcca ctccctcttc cctggctgcc 2184001 tgcagcactt tctcatcttt aggttcagaa acgaaccctt tcggaatcac gaggcgcttt 2184061 actttatgat gcttcagcag aatctccgcc tctccgatat gatcttggtc agcgtgcgtc 2184121 agaattaaag cgtcaagctg cttgattccc ttagcagtta aaaacggaat cagcaccttt 2184181 tcccccagtg aaaacggatg ctgtttttcg cgccaaggct ctgacgagta agacaaagtg 2184241 ccgccggtat caattaagac acgaccccgc tgatgcggag cacctacaaa catgctgtca 2184301 ccctgtccaa tatctatcat atccacttct ccttcggaac taagacacgg atatataaag 2184361 agcagaaaca tcaccgtgca gcaaatgcct ccggttacca tcaactgcga caaggagcgt 2184421 ttttcaatcg ccataagcaa taggatgatc gtgactgtga ataaaaaaag caaaacaggt 2184481 gcaggatgtg cgatcataat cgtgaacaca tcaacatctg caatgtttgt gattaaccta 2184541 ttgatccagc ttatcaataa atcaaaccag ctgaaaaaca atctcccaaa cgaagcggaa 2184601 agacttaata gaagaacacc tgctacagct cccggcaaaa tacagaaggt ataaaatggt 2184661 accatcaaca tattcatcgg tacgctgatg atagaaaact gatgaaaatg atataggaga 2184721 atcggaagcg agcccagctg agcgatgagt gatacaattg tcagctgccc caaggaggtt 2184781 ttaacctgct gaaaaataga agaggataga attaaagaaa aactgacggc gaacgatagc 2184841 tgaaaaccgg cttcaaagag atgataagga ttgaagagca gaaggacgat gtacgaaagg 2184901 caaattgcag ttgcagagcg gacacgccat ttgacaagac ttccagctaa gtaaacaccc 2184961 gacatgagag cggcgcgtag cactgaagga gcagcgccgg tcaacatcac atagagcggc 2185021 agaaataaca gcaacagaat tgacgccttt tctctagtta taccaaggcg gatcatgata 2185081 taaaacaaac ctgctgtcaa aatccccacg tggagtcctg atattgccaa gagatggaca 2185141 acaccaagct tttgatacgc ggtaagcact tcatcctcca cgtaaaatct gtcaccaact 2185201 gtaagtgcct gtacaatccc tgtcgaatca ggaggcagaa ggctgtttgt gaatgatatg 2185261 atatgttttc tcaagctgag caccttgtac ttgaaatttt caggttcgct gcagttttgg 2185321 atagacgtga cagagtagtt ccaatgaata tgctgccgat aaagatactc gttataatca 2185381 aatgcacccg gcacagttgc gtgattcggt tcttccaatg taccagtcaa ctcacatgac 2185441 attcctggtt ctatgtataa cagctgttct ttttcaccag cagactgaat gcgatacgca 2185501 gcagcccatt tttccttatc aggtgtctca accatcatag acatacggtc gccgtcaatt 2185561 ttgggaatag tgtcaatcac tgccttgaat tgataggttc cctgccgata ggaagagaca 2185621 ttctgagaat ctgtgactgc atacagtaca aaaaacaata taaaagagaa gaaacaaaca 2185681 ataataagaa aagcgtgcct cgttttgatt aaaatgatga ggagaaagag gatgaaaaga 2185741 aaaatagcgg ggaaataagc ggcggcagta attccagccg ttgccgaagc tgccgccata 2185801 ggcaataata agcgcgaatt acgcattcat cacacgtagc tcgtgaaaag tgtattcgcc 2185861 tgttcatgta tctttttcaa ttcttcctcc gctaaaccgg catcagccaa tttccctatt 2185921 agacccgcta caaatgaaag cttttctctg tttttcagat caacgatcat ttcatcgagt 2185981 tcaacctgtt caacagttac acccgcctgt tcaaataatt cctgcgcata cggatgtgtt 2186041 ttgtaatcct cagcataata aaccgttttg ataccagctt gaataataga tttgcagcat 2186101 tgaatgcacg gataatgcgt cacataaatc tcggctccat cagtcggcac cccaaactta 2186161 gagcattgaa gaatcgcatt catttcagcg tgaatggttc ttgcgcaatg atcatctatc 2186221 attaagcatc cttcatctgc acaatgtacg ccgcccgcga ttgacccatt gtagcctcct 2186281 gctatcatgc gtttgtctct gactatagta gcgccgacag ataatctcgg acatgtgctg 2186341 cgcagcgcca ataaatggct ttgagccata aagtattgat tccatgaaat tcgttccacg 2186401 ttgttccctc caaatgttgt gttgcctgac ctttagttta cctatcataa tgcatgaccg 2186461 tcaaatcact ttactgtaat ggaagacttt attttctcaa atgacttttc acctattcct 2186521 gaaaccttag tgatatcttc aattgtttgg aaacgaccgt tttcctcccg gtatgcaata 2186581 atagcttcag ctttggatgg ccccacccct gagatgcctt gtaactcctc taaggttgct 2186641 gtattgatat tcaccagcgc tcccttccct ccatcgcttt ggacagaccc tccgccacct 2186701 tgctgcactg ctgtttcctc tccctttttc gggatgtaca ccactgtccc gtcctgcaga 2186761 atctccgcca aatttacttg cgcttcgtct gcttgttcac tggtcccgcc cgctttctca 2186821 attgcctgag atactctgtc ccctgttcgc atttcataaa cgccaggatg ctgaacagca 2186881 cctttgatgt ctatcacaat tgtttcgttt gactcgtcgt tgtttgcttc ctgctttacc 2186941 actgtatttt ctgtctctgt tggtacagct tgcttcaccg gctctttatt tttccctgtg 2187001 gccagaaaga tcataatcgc tgtgaaaaca gccgcagaag ccgctaaaat aattgctttc 2187061 ttatgctgat tcaaccaatt catcgtgcat gttccccgct ttcgtcatat tttattttca 2187121 taacacatat ggtttagagg ataatagctc aaaggagggg aaaccattga agataggctt 2187181 tatcggcaca ggaaatatgg gtacgatcct tatcgaatca tttattgaat caaaagcggc 2187241 cgatccctca aacatgacaa tcacaaaccg cacaattgaa aaagcgttgc acataaaaaa 2187301 ccgctacaac agcataaacg ttaccgaaag tctcgaaaag ctcgtttctg aaaacgagat 2187361 gatttttatt tgtgttaagc cgcttgatat atatccttta ctggcaagag cgttacctta 2187421 tttaagaaaa gatcatattc tcatttcaat tacaagcccc gttcaaaccg aacagctcga 2187481 acaatatgtg ccgtgtcaag tggcgcgagt gatcccaagt attacgaaca gagcgctggc 2187541 aggtgtttct ctcgtcactt tcggcacaag ctgcggcgaa tctgcaaaag cgaaaatcaa 2187601 tgagctgatg cagcatatct ctcatccgct gcaaattgaa agtgacatca cgagggttgc 2187661 atcagacatc gtaagctgcg gccccgcttt tatgagctat ctgattcagc ggtttataga 2187721 tgcagctgtt tcggaaacat cagtgtctaa acaggacgcg attttgatgt gtaaggaaat 2187781 gcttgtcgga atgggaaaac tgttagaaac cgaattgtat accctgcctg cattacagga 2187841 aaaggtttgc gttaaaggcg gtgtaacagg agaaggcatt aaagcgctgg aaagcggtgt 2187901 gcaggatatg tttcaccggg tatttcaaaa tactcatatg aagtacgagg aggatatttc 2187961 cgcagtgaaa aagcagtttc atgtgtagac gagtatgtca tacgttcgtc tgtactgcaa 2188021 aagcataaaa aagcatttta aaaaaccatc gttttaggaa acgatggttt ttgatttctg 2188081 cgccttgaaa aagaggcgtt ctgattgtgc tgatggctcg gtatccgtaa aatcagctgt 2188141 cacgcgatgg agctgaaagc cgcagttctt aagcatttct tcgtattctt ccaccgggaa 2188201 cgttctttgc tcgtgtgtct catcaaaacg atcatacgct tctccgttcc acacaaaaaa 2188261 cgacatatca tgaatgacag aaagctcgtc acttccggca aagctctgcc aaatatagct 2188321 gatatcttcg tcctggtcag caaatgtgct atccggaaag acttccgcaa ttttaaaaga 2188381 tgaatgaaca tcaaacagca ggatgccttc aggctttaat acccgaaaaa cacttttaaa 2188441 ggtttcgatc acatcatttt ttgtttttaa ataatttaat gagtcacagc atatcacaac 2188501 agcgtcaaat tgaccgtcaa agccggtaat ctctctcata tcctgctgaa gaaataaaat 2188561 aggctggcta ctcgatacct tttgctgggc gaaagaaagc atctcttcgc tgagatcgat 2188621 gcctgtaacc tcgaagcctt tttcggcaag ccggatggag atttcccccg tgccgcatgc 2188681 cagatcgaga atacggcctt tttccgggag agatgcttca atccattttg tccattgatc 2188741 gtaaggcgcg tgtgacatta gctcgtcata cacgcttgca aagccttgat aaatcattga 2188801 ttcattccaa agtcaagatc tgcgagcgga gcgtctcccc acagcttttc aaggttgtag 2188861 tagcttcttt catccttgtg gaagacatgg acaactacat cgcctagatc aacgagaacc 2188921 catcttgctt catcaaagcc ttccatcttt ttgacttgaa tgccgttttc atcagcttga 2188981 tccttgattt cacgggcaat cgcctgtacc tgtttatctg aatttccgtg gcagatcaga 2189041 aaataatcag caaccagaga aataccttcc atatccagtg ctaaaatatc ctctgcccgt 2189101 ttatcatcgc aagccgcagc tgcgatcttt aaaatggact tttggttcat tcacaaattc 2189161 ctcctgttca gctgccagac acaagccagt tatacgttaa aaatgtgtct ggaaaaaccg 2189221 gttgattttt tttcataaga aaaaccattg tatttttaat ggactgaatc agcgcttgat 2189281 tcaaatctgt ctcagcaagc ttacgcacct catcgacacc gggaaatgcc cggtttggct 2189341 caatgtaatc ggcaacgtaa atgacttttt ctaaaagtgt catgccgggg cggcctgagg 2189401 tatgatacct aatggcgtca agaatgtctt catcttgaac ccctgcctct ctttggacca 2189461 aataagcgcc gaccggagcg tgccagagct ccggattatg atccaataaa tgcgcaggca 2189521 ttttttcacg cgcaataatt tgtttcattt cttctttcgg gcggaatttg gcgtaatcat 2189581 gaaagattgc cgctatttcc gcttttttag aatcggctcc aaaacgctcc gcaagttcga 2189641 tcgccgtgtt catcacgcca accgtatgga tatatcggtg ttcggtcaat tgctgcttca 2189701 cgcatgcaag tgcctcctca cgattcatat aaaccattct cctctacata cttcttcact 2189761 ttatcaggga ttaagtagtc agtgggcttc ttgcttttaa accgttccct tatcatagtt 2189821 gatgatacct caaattccgg aacgtctgca aagagaagcg gataaggggt ttcaacatga 2189881 aaaccggggc gctttactcc aataaattga atgaggttca gcagctcgtc cagcttatac 2189941 catttcggca aatattcaat catatcagcg ccgataataa agaacagctg atcatttgga 2190001 taacgctgct tcagtaaaga aacggtatca aaggtatatg atggcccttc tctttccatt 2190061 tcaacaagct ccagcttaaa ggacggatta gattgaattg caagctttag catttccacg 2190121 cgatgaaagc tgtcggtata gtcttcgttc tgtttatgcg gcggaatttg attaggcata 2190181 aaccaaattt catcaagccc cgcctggtac agcacctcat tcgccattaa gaggtgacca 2190241 ttatgcggag ggtcaaacgt gcctccgaaa attccgattt tcttcatttc aaccaccttt 2190301 aaggaagctc gatttgttta ttttcctttg attccttata taacacaatc gtattgccga 2190361 ttgtctgcac caattgagag cggcttcctt ttacaagagc ttccgctaca tcgtttttat 2190421 cctcttcgca attctgaagc acgctgactt taatcagctc tctcgcttca agcgcctcag 2190481 caatttgttt aatcatgttg tcgtttactc cgcctttacc tacttgaaaa atcggcgtta 2190541 aatgatgcgc ttttgaacgc aaaaaacgtt tttgtttacc tgttaacatt ctgttcctcc 2190601 taattttcct attacaatag atctcatttt ttcaatatta ggctcttgtc cagtccacaa 2190661 ttggaaagac aatgctgcct gttcaacaaa catgcccaca ccatcgagtg ttttcaagcc 2190721 tttttggctt gcttctttta aaagtgccgt ctgtattgga ttatacacga tatcacatac 2190781 gacggcactg ctcgcggcac gctgtaatga aagcggcaca tcgtccacgt tcggatacat 2190841 gcccacagac gttgtatgga tgataacatc atactgctca agacgttctt ctgcttcttt 2190901 tatgcttaat acttctttat tgtgaaacga gggagtagct tctgtaagcc gctttgcttt 2190961 ttctaacgtc cggttgcaaa tgtcaaattt tttcggggta tttcggacaa ttgttgtaaa 2191021 aatggctctc gccgctccgc cagcgccgat cattaagaat gacagttcag agatgggctt 2191081 gtctaatacc ttcattaatg acttcacgaa gccttcccca tcggtattgt atccgacaag 2191141 cttatctccc tctcttctga ccgtgtttac ggcaccgagc acttttgcac tctcatcaat 2191201 atgatccaaa taatccataa tggaaacctt gtgcggaaca gtcacattga ttccttgtac 2191261 gcctagagct cttattcctt ttaccgcatc ctccagatca ttctcttcta ccttgaaggc 2191321 atgataatgt ccgtcaagcc cgaggtcttt caatgatgcg ttatgaatat caggtgacat 2191381 agaatggcca ataggatttc cgataacccc gtacagcttt ttcatacacc tctccccttt 2191441 tcttaaatta atgaacgccg aacaaataca tgaacgcctt ttggcgcgta tgcagttacc 2191501 tttttatcag cgtcatggac agtaacccag cctaacccag agaaaacgat atctgtcttt 2191561 ttgtctttta tcgtaaacgt atgggcgacc aattcaggaa actcatccat ttcatcttta 2191621 cccggaggtg tgagcaattc ccctgcatgc ttttcataaa gcgcgtctgc attttcaagt 2191681 tttgttctat gaatcatcag ctcattcggc atatagcaaa taaaaggaga tctttcccca 2191741 gacacataat caaaccttgc aagtccgcca aaatacagtg tttgctgatc attaagctgg 2191801 aatgtgcgag gcttcagctc ctttttagga gataatattt tcaggtcctt tttattgaca 2191861 taatgcgcca tttgatggtt gttgataatt cccggtgtat cataaagcga tgaaccgtca 2191921 tccagcggga tttcaatcgc atcaagggtt gtgccaggaa attgggatgt tgtaataata 2191981 tcttcttcac ctgacacttc tttaataatc cggttaataa aggttgactt tcctacattt 2192041 gtacatccga caacatagac gtcttttccg ttgcggtaat gctcaatcgc gtcaattact 2192101 tctctgattc cctggccgcg acccgcactg accaaaaata cgtcaaccgg ttttaagcca 2192161 agctctttcg cttcacgctt catccattgg atcagacgct ctcttttcag tgacttaggc 2192221 aaaatatccg ctttattgcc aactaataag atagggtttc cccccaccaa gcgctgcagc 2192281 ccattaatcc agctgccgtt aaaatcaaaa atatcaacaa tttttacgac cagagagtcc 2192341 gtttctccaa taccgtgaag aatgttcaaa aaatcatcat cagttaagga gacatcttgt 2192401 atttcattat agtttttcag tctgaagcaa cgctggcaaa tcacattttc tttcgtaagc 2192461 gatgcaggcg gcgcgtaccc caaacctgtt ttgtcctcgg tttggatcgt aactccgcac 2192521 ccgatacaaa caaccttttc catttcttac tcctcccact gaatgtgccc ttttcgtttg 2192581 agagcactca gtattctgcg ttcgacctgg cggttaaagc gcgtaatgaa tccgtcagag 2192641 gaagcgactg gcacgaccaa aatcgtatgg tagccgtttc ggtttccccc gagtacatcg 2192701 gtcagcagct ggtctccgat gacaacgcag tcctcttttt tcagctccat attgcgcacc 2192761 gctctattaa aggctttacc catcggtttt cttgctttat agatgaatgg gattccaagc 2192821 ggttctgaga aaagtttcac tcttctttcg ttattattag agacaattgt cactttaatg 2192881 ccgtgttcct tcatttcttc aaaccactcg atcaatcgcg gcgtcgcgtt cggcctgtcc 2192941 cattcaacaa gcgtattatc caggtcagta ataattcctt ttacatttcg ttcctttaat 2193001 ttctcaggtg taatatgaaa aatatttttt acaaactcgt caggtaaaaa aaactttttt 2193061 aacaaaaccc gcacccttcc ctttttcttt ctttcaaaat gattgtcgaa aaaaatcgaa 2193121 cttgcgccta aagaaaaact gagcaaaaaa atttcgacaa aaattgggtt tcttcaccag 2193181 gtgtggataa atttacacac actatccact cttattacat cactctttag acaaattata 2193241 aacacgatac tcacaagtta tccacttttt ggtgtggata acagaacgat tgttcttata 2193301 tgcatttcat ggtagattaa agataacttc aacctcagat gaatgcaact tatcattgta 2193361 tgcgttaaaa tcatgaatga ttccaacttt taaggaggtg cctctcccat taattgggtt 2193421 cctagcatga gaaaactgtc tgatgaatta ctaatagaat cttatttcaa agccaccgaa 2193481 atgaatttaa accgtgactt tattgagtta attgaaaacg aaataaaaag aagatcgctc 2193541 ggacatatta tttccgtatc ttcttaatag gaatttgtct attttttccg ggcgtatttc 2193601 ctttttttac tcagatgact gatattatat cactttggct gcgcgcttta ctactatttt 2193661 cagcaaaaaa cacccctaaa aagaggtgtt ttaaagggcc ggttattatg ctaaccagta 2193721 tatgccgccc acaacaagga gaacaacaac taaaacaaca ataaaagcgt atccatatgc 2193781 tctgcctgcg ccatacatgt gaagcgcctc cttaataagg ttttataaca gcctatgtag 2193841 gagaaataaa tcggactagg cggttgtccg gctcaacgct gcaggatctg ccccgcgaac 2193901 taatttatta atgttcaaca acagaatttc gtctattggc aataaagaat ccacaaatca 2193961 ttgcaagaat ggccatcgcc caccagaacg ttgagatcgc ctgatcatga tcgatgataa 2194021 tcaaacgaat gacagctgtg atgccaatat aaatgaagta gcgaagcgga aaatgaaagt 2194081 ctgatttgaa gtatttgata atcaaagcaa tgaactcaaa gtacatgaag aatataagca 2194141 gttctccaag catctcataa tagctgtcca ctttgttgaa cagtgacttg tatacgaata 2194201 gcacaatgta ccaagtctcg ctgatcagaa gtgcgcttaa ggctaacgcc agaaagaaca 2194261 gacagacgtt gagaagcgct tgtaacaggt aaggcacctt tttgaatttg ttagaaaatc 2194321 tcatcatgtt gtctcctatt tcaatatatt cgtggttttt attctcagcc tacatcttgg 2194381 tgttccaaaa tcgtagcaca atgtagtact tagaattctt ttgtatactg tgaaactgtc 2194441 cctgcatgcg ggacatcatt cgcgcaatgc ttctttcacc gagtccgttg ctttccggtg 2194501 ttatatctgc aagtttaatc gtattgctaa catggatctc aaatatctct tgatccgata 2194561 caaacgtgat actgattttt tcttccggat ctgcgtattt caataagttt gacatcacat 2194621 tatcaaatac acgaccaagc tcctccaaat tcacgttaat ataggtttcc ggcagctcgc 2194681 ctgaaatatg gacccgaaaa tgctcctgat gaaggatagc aatctgatct gatattagat 2194741 cgtagatcac ttctttcact gcaacggtct ccagatcggc ctcatattcc ttgttcagca 2194801 ggaaatacgc aaacagattg tcagacaagc tttttaattg cagtgcttta ccataagcat 2194861 tggctacata ccgatctttg ctggcacccg cttcgcctcc ctcttttttg gcaaactcca 2194921 gattcatgat cagcgacgtc agcggtgtgc gcatatcgtg cgacatttcg gtaaccaggc 2194981 tgcggctctc agcttgcaat tcctcgatag ctttaagttt atccaggaaa gctttccgca 2195041 gatcctcaat gctctttgca atcatcgcta attcatcatg cccttttatc gtcatctcgt 2195101 agtccagttc gcccccttca agaatatgaa tctcttgatg aatcgtttta aggtagcgaa 2195161 gactttggcg aattccgaag agaacaatga ttaaaaagat gagggttgcc ccgagcaaat 2195221 ccaatgcaaa ggccagatca taatatcggg aagagtagaa accgtcgata atgactcgtc 2195281 cttcaccatc gctaaacttg acaggatgtg aatgattttg agcgtactga gtcagctttt 2195341 cctttccata atccgattcg gaataaatag aatcatattg cagctcctga tccttgaata 2195401 tggtgaggtt aatgtaattt tcttttttga cccactcgcc aaacgctttt ctatctgatg 2195461 tagacaactc attttctgaa acgtacttgc tgaatttttg aatgtatctt gctgactcct 2195521 cgtgataata ctcttccgaa ctcagatatc cctcgatcag atcatctgtg atcttttgca 2195581 acgtcagaaa gatcacacca ctcacaatcg cagcaaccat tatcagcaaa gccagttttt 2195641 tggttagcgt aaatttaaga tgcgccaaat cgatatcctc ttccccattc agtttttata 2195701 taaaccggac gtgccggatc atcctcaatt ttggagcgca gcttccgtat atgcaccatc 2195761 accgtattgt tggaacagta aaagtaaggc tgtccccaca cactctcata tatattttgg 2195821 gcagaaaata ttttgttgcg tttgttcatc agaagtttca ggatacgata ctccagatct 2195881 gacaacttga tttgcttctc ctctttccac acctcattaa attcttcgct cactcttagt 2195941 ttgcccccga taagaaatgt ttcttcctgt tccttctttt cctgatagat agtatatctg 2196001 cgtaattgag caatcactct agcgtgaagt tcctcttccg agaatggttt agtcatataa 2196061 tcatcgccgc cggcgagtaa tccctcagtt ttatcgagtg tactcgatct ggccgtcaga 2196121 aacagaatcg ggacgttaga ggatttcctg atgtgctgac atgtttcaat tcccgaaatg 2196181 cctggcatca taatatccaa aataaccaaa tcaagcgagt cattcacaag ttgcaatgct 2196241 cgctttccat ccttggctct tagcacctcg taacctgcac gtgtaaggga ttcctccaaa 2196301 agatcaccaa tatcctcatc atcctctacg actaatattc gataggccat gtctctctca 2196361 cctcatgatt cttgttgtta tttctcgtgt gtccttacta tatatcgttc atagtaataa 2196421 gtacgttata agatactacg taaatcttaa caatttatga aagctgatgc tcgccacaaa 2196481 tttgtcacat tttctaaaaa aaatgatgac tcttcataaa ttgttaagat tcggtcttta 2196541 tatttatcca ttgtaaggct caagtttttc agatccgcac tacacattgc cgtgataaat 2196601 gggaaaggag tattgatatg attgtacaaa aagaaggacg cgggcaaccg gtgagtctgc 2196661 gggaacgggt tcattttctg gacatcgtac gaggatttgc cttgcttggc attattattg 2196721 tcaattattt tctgatcgta gattcagtaa agggattcga aatggcctcc gatgacgtac 2196781 tgcataagct ggtttcctgg tttgccgaag ggaaattcgt tacgttattc tccttcctgt 2196841 tcggagtcgg gtttatgatc tttatggatc gagccgcgca gaaggtagag agtcccaaca 2196901 agctgtttgc ccgcaggtta tctatcctgt tgggatttgg cattttgcac atcacatttg 2196961 tttgggtcgg tgacatattg gccttttacg ccgtaagtgg cttcctgtta ctcgccttct 2197021 ataaacgcac ggccaaaacg gtgcttagat ggattatcgc acttatcgtg tttcaattcc 2197081 tgactcctgt tttcacaatg ttgtacaatg tcatcaatac tgcagggtca aaaaacccga 2197141 atttttcaga gtttactttg tttagccaca gcagccttac ctacatggaa tccatcagca 2197201 ctcggtggac agatatggtc acgatggctg ccggctcttt ctctatgatc tattccatgt 2197261 ttctcatgtt tctgctgggc gtgtactttg ttaagatgga atttttcaaa gacatggaag 2197321 cgaaaaagcc tatatggaag cgtatctgga tcattagcac aatcgctttt ctaataacac 2197381 aaagcagtat attactagac atgtttaatc tttctgagaa tatgctgtgg aaggacattt 2197441 cctctgtctt gggtcaaaat ggcggcttaa ccggaagtat gttttatatg agcacttttg 2197501 caatgctgtt tctatacctt cctcagctgc gaggccctat gatgatattc accaaagtcg 2197561 gacggatgtc attgacctgt tatctgcttc actctatcat tggaacagtt ctgttcctca 2197621 ggtacggatt cgggcttgcg gatcatattc aatccgccgg cacgttcatg ttcagtctgg 2197681 ccgtgtactt cgttcttatg agctttagta cattgtggtt gaaacggttt aggtacggtc 2197741 cgatggaatt agtatggcgc aagctgacgt acggcaaagt aaacgggagt cccaaagcaa 2197801 ctccgctgca ttcggaaaaa tctattcaga aataaccccc ttgcacagat tgcatgactt 2197861 caaattagtg ttgttgaatg aagcgggcat taaacggaca gatttgatat atggactagt 2197921 tatttttata tcatttaggc ttctttgggc taataaatcc accagagttt actcaatgtg 2197981 cattgctcat gatcgaatct aaattgaatc ttttacgcat gttcatagtc aaaggcgcct 2198041 cattcgacta tttttgtaac ttttcgcagg aaaaattcga gaatgatgac aaatcccgca 2198101 tacgacactt aatacggtag tgaacaatag taaattaggg ttacatgcag cttgttttcc 2198161 aatgaaacaa agaaaaagaa tcatacaaaa agacaggaga aagcttttga agtattttaa 2198221 cgccaaattt accgcggaag aaagagcgat ggaatcactt ttttgtgaaa aggcctcgca 2198281 gagcagctcg aatgttttac tgaacgactg aactctatat tttagcaact gagggagtga 2198341 acaatcatga aaactaaaaa tgaaccaaaa gttattctgg aactagcaaa ggaatctgat 2198401 ctgccagaat tccaaaaaaa attacaagaa gcctttgcga tcgccgtgat tgaaacgttc 2198461 ggtgattgcg aagatgggcc gattccatcg gacaatgatg ttcaggagtc tttcaatgct 2198521 cccggagcag tggtatatca tattcttcag gatggtaaga atgtcggtgg tgcagtagta 2198581 cgtatcaaca gccaaacaaa tcataattcg ctagatttat tctatgtatc tccagaatat 2198641 cacagccaag ggattggtct ttctgcttgg aaagccattg aagcacagta tccggatact 2198701 gtgctttggg aaaccgtgac accttatttc gaaaagcgaa atatcaactt ctatgtgaat 2198761 aagtgtggat ttcatatcgt agagttctac aatgaacatc actctaatcc gcatatgcat 2198821 cgcaatggac gtgaagatga caagccccta ctgaatgatg atgacttttt cagatttgta 2198881 aagattatga aaaaaaagga ctaaacaatt gaacacggcg agatgccgca gagagttgct 2198941 ggtaactttt ttatatttca ttatcagagg aaggtaataa tgatgtttaa aaggtgtttt 2199001 gatccctgtc tcataaacag gggtcaaaac acctttgaat catcggtttc ttttctgaca 2199061 tataccacgc ccactagtcc ctcaacatag taaaaacata tcatgagtta caaaagcttt 2199121 tattcaaagc atatgtttat tttatttata cttattttca tcatttttca gaattctgga 2199181 cacaaatcgg gtacctatta gaggccaagg aactctacat ttcattaaga aatacgtact 2199241 cattgccctg ctttaattaa ttttaagccc tcgcactatg cccccccctg aattaagtat 2199301 ttgatgtaac tttgaaatta agtttatgaa aatctgtcac aaacccttat ttcataacac 2199361 atcatttgtt tcagcttccc tcgcgaatac cggattaatg ctcggcttta agatagtcaa 2199421 ccaatctctc cgcactgttc ttaacatctt cttttgaaag atgaagtgtc ccatattgtg 2199481 taaacgcagg aagaaaacgc attcctatat agttagcagt gacttgaaac ggtctgataa 2199541 gctcgctgat cgtgatatta tattctccgc ctgcttgata atcagattcc tgtgcgccta 2199601 aggagatagc taagagtagt tcttttccat gcaatttagt tcctccagtt ccataagccc 2199661 agccatgtgt taacacatca tcttcccatt gtttgagtaa cgcgggactg ctgtaccaat 2199721 acattgggaa ctgaaaaacg atacgctcat gatctaacag gagctgctgc tctttttcta 2199781 catcaatgat aaaattaggg tattcaccgt acaggtcatg aaccgtaatg tctttctctt 2199841 gctttaaacg attcatccag gttttgttga caacagacgt ttccaaatta ggatgtataa 2199901 cgataactaa tgttttcatt agactgatta tcctttcttt gccaattagt tattattttt 2199961 tacgataatg aattgattct aattttaaaa tagcaacttt atttacacct attttatcct 2200021 ttttcatgaa ttcagggcaa ctaattgggc accaaaatca atgatgactt aagacattgt 2200081 tttgtagaaa tccgatatac agaataatcc attatttaga aaatttctac cttttccctc 2200141 aatccgagct cgctcttcat gcggatggcc tattttaaag gaataactga ctatgttcat 2200201 cagttattcc tttaaaatac gaaagtctac gatatttcca tatcgatccg cttcaatgtg 2200261 acagcacccc tcaagcagct gttttaattt tccacgtccg cgttgtaccc ttgattttgc 2200321 tccggagtaa gaaatgccga gcttttcact caactctttt tgtgataacc cctggaaatc 2200381 agttaactcg agcgcctctc gatacttttc aggcaaccgt ttgatggtcg atcgaataca 2200441 cacagttgct tccttggtga aattttcttc ctctgcactg tcattaaaat gtagaacatc 2200501 aggcaatatt tcgcttgttt tttttgtacg gtaaaaatca ataatcgtat ttctagtgat 2200561 ccgataaatc cagctgtcga tcttttgttc atcgatcaga tttgggagat gcacttgtat 2200621 tttcataaat acgatttgca agaggtcatc aacgatagat tgatcgttaa ccctatgtga 2200681 aatatatgtt tttaacggct gatgaaattg atcccataga tcctctatat tcatttgaaa 2200741 aaacctccta taattttgcg tctgctttac atttgcttcg tctttttaat cgtaacaaag 2200801 agcaaacaat tgttgaatca attgtattgc agctgttgcc aaaaataatg ataaaggaga 2200861 ggtttgttgt ggagtatacc tatttaggga gaacaggatt gcgggtgagc cgtttatgtt 2200921 taggcacgat gaattttgga gttgatacag acgaaaagac tgcgttccgt atcatggatg 2200981 aagcacttga taacggcatt caattttttg atactgccaa tatttacggc tggggcaaaa 2201041 acgcaggatt gacagagagc atcattggaa aatggtttgc acaaggagga cagcgccgcg 2201101 agaaagttgt tctggcgaca aaagtatatg aaccgatttc tgatccgaat gacggaccaa 2201161 atgatatgag gggcttgtct ctatacaaaa tcagacgtca tctggaagga tcactgaagc 2201221 ggcttcagac agatcatatc gaattgtacc aaatgcatca tatcgatagg cggacaccgt 2201281 gggatgagat atgggaagct tttgagactc aggttcgctc cggcaaagta gactatattg 2201341 gatccagtaa ttttgcaggc tggcatttag ttaaagcgca agctgaagct gaaaaacggc 2201401 gattcatggg actcgtcact gaacagcata agtatagttt attagaacga acagctgaaa 2201461 tggaagtgct gccggctgca cgggatcttg gtttaggagt agtggcgtgg agtccccttg 2201521 caggagggct tcttggcggg aaggcattga aaagcaatgc cggaactcgt acagcaaaaa 2201581 gagcagattt aattgaaaaa catcgtttgc aactcgagaa attttcagat ttatgcaaag 2201641 aactaggaga aaaagaagca aatgtggctt tggcatgggt gctggcaaat ccagttttaa 2201701 ctgcgccgat catcggacca cgaacggttg agcagctgcg tgatacgata aaagccgttg 2201761 aaatcagtct ggataaggag attctccgca tgttaaatga tatctttccc ggacctggag 2201821 gagagacacc tgaggcatac gcctggtgat acattcatta ctcaatactg acatttttct 2201881 taaatattta tactgaacta tcatattaag aaagacaaga gcatgtttgt ctcttgtctt 2201941 ttccacatcg tgctgaaaat gctggctaaa catcgacaaa aatgctgccg cttaaaaaag 2202001 aaccctaaac aatagagtaa ctggaaagac aactggcttg atcagcttgg gacccctttc 2202061 agctgtattt aaatcaatca aactaatgat tcattggcag tctaaatatt attattgttt 2202121 ctttacaaaa tagtaatagc ccctgtaatg attgctaaca acgtaataac taatgatgta 2202181 attacagccc acttaacggc aaacctttga aatgacccca agtccatttt aagcatgctt 2202241 actagcaata ctgttgacgc aaccaatgga ctcatcagat gaaccggctg ccccattata 2202301 gaagcccttg caatttctac tggttctata ccatatgctg aggcagcttc tgcaaagata 2202361 ggtaccatac caaagtaata tgcatcattt gataaaacaa aagtaaacgg aatactagtg 2202421 agtgctacaa taacggggaa aaaccctccc attgatgagg ggatgatgga tattaatgat 2202481 cctgctatgg catccaccat ctttgtcccg gataatatac cagcaaatac tcctgctgaa 2202541 aataccaata ataccacggt tatggcatta ccagaatgct cggcgattcg ctccttctgc 2202601 atttttacat tcggataatt tatagtaagg gcaagaacaa aaccaattaa aaataaaact 2202661 gacggatgct tagttccaag cacaataaac accatgatac ttataacgag gaataaatta 2202721 agatatatta agcgtggcct tttcaattgt tcgctctcca aagtagcagc catataagat 2202781 tgagagctgt cctttgttat atgtctaggc tctaattgaa cgatgcctat tcgattcctc 2202841 tctttccttc ccattagaaa agccagaaat atcacacaag caatacctcc aagcatggtc 2202901 ggaagtaatg gcacaaagaa atctgaagga tccaaaccca gcactgaaat cgctcttgta 2202961 gctggtccgc cccatggagt cattccgcta acgatactca acgacagcat tgctaatgtc 2203021 gccataacca tgggattcat accaattctt ttatacaaag gtaacattgc tgagactgtt 2203081 atcatatagg ttgttgtacc gtccccatct aaagcgataa gcattgccaa gacggcagac 2203141 cctatcgcta ttttcacagg gtctcccttt actatagata aaattttttc tattagcgga 2203201 tcaaataaac ctgcatcaat taaaattccg aaaaaaagaa tagcaaacaa tagcaatgcc 2203261 gctgaacttg caactgtttg aattccttct aaaatcatgt cgccaatacc cttaccaaaa 2203321 cctccaataa gagcaaaaac aatgggagtg atggtcaagg caacaatagg cgagactttc 2203381 tttgtcatta ttaatattgt aaaaacagtt accatcgaaa aacctaaaat agtaagcata 2203441 ttacacctcc aagaatgcgc tttcaaatga cttttgatta acatatctta tacggtgtaa 2203501 taagttaaat aaatattttt ttactgtgtt tcaaaaaaaa ttctatcata actttaaatg 2203561 gttaccattt gttcaccctt taaaaaatca atgaatgctt taacgagttt gattcctaat 2203621 gatttttgat cgtacattag ccaagtatct ctcattagag gcttaccctt agcattatac 2203681 agttccattg tgtacaaatg atcagattcc tgcaggcaaa tttctggtgc tatggagtaa 2203741 ccaagaccat gctttaccat ctctttgcaa gtctcttgtc gatccacttc cattgcaata 2203801 atgggggctt gttttagatt cgtatgcatc caatcttcta taatcgtttt taaagaagca 2203861 tccgttttat atttgataaa aggtaaaaaa ggaagttgct ctatcgttat tggttttttt 2203921 gagatgatat gtaatttttc ccgtgtcagc cgttcctcca cccctttcca gcgatggctt 2203981 cctctcagta taccgacttg tacaatacca gcatctaata atttcatgac atctgtgctc 2204041 cagcctgttt gtacactata ttggacatta ggatacatag tggaaaattc ccttaataac 2204101 ttagggagct tatattgagc gaaattgctt gataccccca gccttagatg tccttgcacc 2204161 tctttgctta gattagagat atgatctttg gtatcttgaa gttcctgtag cattcttctt 2204221 gcataagcaa ccaagtgttc tccttccgca gtaaaggtaa ttcctttatg ccttttggtg 2204281 aataattcaa ttccgaaaat ctcctcaatc tttttcaacc gataagtgat ggaaggctgt 2204341 gatgtaaata atcgttctgc tgtttttgtt acactttgtt cttcgtgaag aattttcaat 2204401 aaaatccaat ctttctcatc cattttcatc ttcctttcta gtccttcttt cacaattata 2204461 aaagtttttt tatcgaatat taagaaaact tatattttat ttttattttt ttaccttcta 2204521 cactaaaaaa cataaaaaat actaccttta agatgaggat gatgacgatg gtcaagacga 2204581 atgtaacaat catgagaggc ggaacaagca aaggcgtttt tttccacgaa tcagccatgc 2204641 ctaacaataa aaacgaatgg gagccctttt tgcttgatgt catgggaagt cctgataaaa 2204701 gacaaataga tggtttgggt ggcggtaatt cccttactag taaagtggca ataataaaga 2204761 aagcatatac ttcggatatt gatgttcact atactttcgg tcaagtcagc atttcggaag 2204821 aaaaggtgga ctttaagggg aactgcggaa atatctccgc tgctgttggt ccatttgcta 2204881 ttgaagaagg acttgtaaaa gcgaaagaac caatgactgc ggtaaggatc ctgaatacca 2204941 atacgaataa aatgatcatt gcggaagtag aagtggaaga cggtcaggtc aaatatgacg 2205001 gagatgttac gatatctgga gtacctggat ctggatctcc aatctattta aactttcatg 2205061 atgccgctgg ttcagttacc ggtcatttat tgcctactgg aaatagttcg gagtttttag 2205121 atacaagtca aggccaaata gaggtgtcta ttatcgacta tgcaaatcca ttagtttttg 2205181 tggaagcgag cagtatcggc ctggatggaa cggaacttgc agaagaattt actgatctac 2205241 agttggctca atttgaagaa ttaagatcca ttgcggcaga gaaatgcggc tttgccagtc 2205301 gattttcagc tacaaagtta tcgccggctg tccccaaact ggctatagta gcaaaaccag 2205361 agaaatataa agatagtaca ggtgcttggc attcaagcgt tgagatggac ttacacatca 2205421 ggatgatgtc catgcaaaag ccacatcaag cactggctgt cactggagcg atatgtacaa 2205481 caagagccct ttcagtggaa ggtgcaatcc ctgcaagaat agcaaaaaac cactctacaa 2205541 aggttcggct agctcattct tctggtatta ttgaaacaat ggtggagccc actggtataa 2205601 agatcgtccg taccgcacga cgtattatgg acggaacagt ttatacgcat ggagactatc 2205661 aaatgatgta gatggactgt gcaaaaagcc tccccccttt ccatcgttaa tagatggatt 2205721 gaatgcgcct tcttgcacag atccattgta atcttgcatg gctttaaaaa agcctctata 2205781 ttgtttttta tgaaatcgcc aaggtccttt catgtatctg cctcaagcat gacataatca 2205841 ttatagagaa aattgaatac tttttactgc aaataaaaag ataccaacat cattggtatc 2205901 ttttagattg agttcatctg cagcggtttc ttttcctcac tgcttatttg attacaaaat 2205961 taccgtactc gtttgaacga acatgaatcg gtccgtttag attatagttg ttctccttgg 2206021 cgatagagcg aagcacgtcc acacgggcaa ctgattctct ccattcgtca cgggtgtcat 2206081 gattggccgg attcatcaga tcgtcatagc gtacgtccaa gaatttattc aaccacttct 2206141 tctcgtctat tccgtcttta ggtgatccgc ccgctttttt gttcgtacgt ttaatcaagg 2206201 cataaaaaga gtcagggtca tcaccatcgc catgctgaat aaccgtatcg tacatcacag 2206261 ctcttgccaa tgctgttttt agtccggcat tatccgatcg tttcatggca ggctgataat 2206321 acaaatggtc atttactttg tcttgagcgg cgcgaaattc cttatcattt gcaagcgact 2206381 tccaggcaga agcgaatccc ttgagattgc ttgtatcatc gctttcttcc ttggccagac 2206441 ggcgcaattc aggcagatac tttttcagtt tgttattcgg aactgccttt gtgtatactt 2206501 ccactacttc caatgcatcc ccggtagccg ttgtaaagcc tgcccgtccg catgtatagc 2206561 ctcgcccgtc atccaatcgc tctacatatc catattggat ctccgttgtg ccgttttcaa 2206621 agatacttgt cagctgttcc gcccggcgct tttgatcttt attcagtccc gccgcaaaaa 2206681 ccgtttcgct catcatcagg gtaaaaaaca tggtgaaaac aagtaatgag atcgctgctt 2206741 ttttccaaaa atctgctttt tgcatactga ttttcatttc acttcccctt tctaaatatt 2206801 gtaaatacag actcagtata catgaagaaa ctgccctatt gttgaaaata catcaatttg 2206861 tcaatatttt gaatctaaag taatatagct tgaatcttac tctattcatt gccaatcagc 2206921 cttagcccct ctcactggga aggtcccttg attttcatac tgcttcaact ttcattaaca 2206981 agatgccata aggctttact ctattttata atggaagtga tcatcgaaaa tcgttaggga 2207041 ggtgatgtaa tggcaagcaa gatgagaatg ccagattccg caacgtccca tgcaaagcct 2207101 actattggga aggcgatact ttgcatgggg tagactttct aaaagatcgc ccaagtaagc 2207161 ttttctgata tagtggcttt gcaccttatt tgacataaaa aaataaggag ctggcagaaa 2207221 tggcatatgt aaaagcaacc gctattttac ctgaaaagct gatatcggaa attcaaaagt 2207281 atgttcaagg aaaaacaata tatatcccta aacctgaatc ctctcatcaa aaatggggtg 2207341 cgtgttcagg aacaagaaag ctgatcgatg acagaaacgc ttctattaaa aaagcattta 2207401 aaaacggcaa aaccattcat caattatctg atgaatatca cctctctatt gaaacaataa 2207461 aaaaaattgt ctactctaaa taaacaaaac ggaagcactg ataaaaaata atcagtgctt 2207521 tttatatggc gagtttgttt cttagttatt tcctgcatat gataccattg gccaattgtg 2207581 taaagttaag ggagatgaga agaaaggaag gtcctacaaa tgacgataaa caatggaacg 2207641 ttgcaagtac ccggcgcgaa catccactat caggtgcgtg gctctggtcc aatcattctt 2207701 ttggtccacg gaggaggcgg tgatgccgac aagttccatc atgttgccaa tcatctggct 2207761 aactggtaca cggttgttac ttatgatcgc cgcggccatt cccgcagcaa tctcgccaat 2207821 cagattgagg gttaccgtgt ggaaacacac agtgacgatg ctcaccgtct tctagccaaa 2207881 atcaccaata agccggccta tgtatttgga agcagctccg gggctgttat cgggcttgat 2207941 ctgtgcatac gccatcccga acaagtacat gtcatgatcc cacacgaacc aatcttattg 2208001 cagcttctgc atggaaatga gctgaaacaa gccgagcaat tcatggaaga ccttaagaaa 2208061 aatcatcgaa gtgaagtcat taaattaatg tcaagattag agacagacga acaatcaaag 2208121 gctgtcctga caaagcggct tctcggcaat tcaacgtatt tcactgagta tgaaattcaa 2208181 ggaattctca gctatacatt agatttcgaa gcattaaaaa ctgtgtttac atcttcaccg 2208241 atgaagatac tcccagctgg cggaagtgct tctcgggagc tttttcctta tcgttgcgcg 2208301 aacgccctag cggaacaatt ggaaacagaa tgggttgaat tccccggaaa tcatacgggg 2208361 tacacaatgt accataaaga attttctgag aggttacacg acatgttaga aaaagaaaag 2208421 aaacatacgt gttaaggatt gattaaaatt ttcaaaatag gacaggtgaa actaactatg 2208481 gaattggaga agatttcacg aagcgtaaaa agaacttttc actaacgaga acgcaatgtg 2208541 agatgtttaa ccaaagtgat attagggatt tcatcgaaaa ataggtttgt acattacgtt 2208601 ctcctattga ttatttccta tcttaattcc gtattttata ccattagata caactctaaa 2208661 gcggctcgtt attttgtcct caacaacaac cagtgtctaa catcatgaat ctcttttgaa 2208721 aatcaccaca aatgcaggta tggaagactt catcgcagca aaaaccatac caactattgt 2208781 tgttggtatg gttcgtccta gataggccct taagaagaga ttctattgta cggagtattt 2208841 agctaattgc atttgtaacc gacagggccg tctgaacctg tgtacacata tgtgtcagac 2208901 acatatccaa tattcacgac accccgggaa tctttccact ggatttggtc ccagatatta 2208961 ctcgttccat acttccctgt aacagtcgtt ccataagcgt aacaataata aggaacacgg 2209021 gagccactcg gaatggaaag cataatagga taatttgtac caggaccgct gcgcatattg 2209081 acaggcgcac cgctgcttgt tgagacagta aagtactgaa cggcaagtgc ctgactggaa 2209141 aaaatgaata aagatgcaat catcacggtt aacatactca gcattttcag tttagtcaat 2209201 gtcatccctc tttcttcaat tccttcattt taagaaacga tagaacatag gctaccagct 2209261 gcatttagga acaaccggac cgtctgagcc tgtatacata tatgtatcag agacaaatcc 2209321 aggaacgatc tccccgctgg caagcgtccg ctctgtgtaa ttccaaatat tgctcgttcc 2209381 atactttcca gttacagttg taccggtttt gtagcaatag atcgggatgc gggttccgct 2209441 cggaatggtc gttacaattc cccaacttgt acctgggccg ctgcgcatgt tgacaggagc 2209501 accgctgctt gttgaaaccg tataatactg agccgcaagt gcatggctag aaaaaatgaa 2209561 cacagatgca atcatcaccg ttagcatact tagcctcttt aacttattca ccttataccc 2209621 tccccttata aatgccgtac gtttgacttt cttacatcca gttaaggatt tactttcaga 2209681 taccatgccc cctcccctcc catatattta tcaatgtacc ataaactaga tctttcaaaa 2209741 gtggaattat tcctatgttt tcgacaatta aggatacaaa ataaatggta gtcaggcttg 2209801 atattgatgg tgtgttacat ttggctctta atcatttgtc cagtcggtaa tcacgattga 2209861 caatcaggaa aaaggacatg gatcaagcgg cttcgtttcc accaattaac tcaatcagtg 2209921 tactgcttcc ttgtatccac gcttcttctc gattcataga tactccacct ttttcaccaa 2209981 tcaaaaacgg acaccataca aatcagcgta aatgctgcaa gttcagtgtc cgcaacctat 2210041 tatgactttg ctttctttta ccagggcgtg taaaaatgat taggtacgtt atcaaacgtt 2210101 attctatgat tttgcgagtc aaaaaatcat aacattttat atatttcaat cagattatga 2210161 tctggatctc tgaagtgagc aactcgggca ctccattcct tgcgatcatg cggtttattc 2210221 tcacatttaa ctcctttttc gtgtaaatcg tcatacgttt tatcaacatc ttctacctta 2210281 aactgaagca aaaattttga ttgagcttct ccttccaagg actttttttc ctctccaacg 2210341 atttcagcca tcgtttctcg agataaaagc tctattttcg tttccccatt atcaaagagt 2210401 gcatattcca tttcattctc taaccaactt attggaagtc ctaatgaatc tttataaaac 2210461 tcgacgcttt tcttaaaatc attcaccaac agtctaattt gtaacagctt catatcgagt 2210521 gcctcctata aaaccatact tttactggtc atccaattta atgataccaa agaaacctga 2210581 cagcactatg tcaagtttcc atacttcacc cttatttcag atttaagtgc agtttagtcc 2210641 atgtcataag aacgagcaaa aacagcgatt cttaaaacaa aaaatgatac cgagtgtatt 2210701 ttctgtatgc ttcaacttca tttcgggaaa tgtaacgttg ataaaaggag gttacatcaa 2210761 tatggatcat caaacattgg cagctcatga ggctgttgac ttacatgaaa tcgtgaactt 2210821 taaaacactt tgtatagcga aatcaaagtt aatgcaaggg cttgtgtttg accaagaact 2210881 gaaggacttg atggaaaaag atgtacagca atccattcaa gaccttactg aattacaagc 2210941 ggtttatgag cgtgcctcat ttcaggcccc tgtccctcaa agccgcccaa cgccaatcat 2211001 caattgaaag ggaggtaagc ctctttgaat aatgatcatt tagaccccat taattcgctg 2211061 aatgtgcctg aactagcaga cactacattc gcgatggatt ttcttatacg agctaaggaa 2211121 ggcgtaagga atactgctgt agctttgaca gaaaccgctt caccagatgt aagagcactg 2211181 cttcggaaac agctgatgca aggaattgcg atgcaccaag agattacgga actgatgatc 2211241 agcaaaaagt ggttccatcc atatgagctg agcgaacagt ataagctgga tcagctctct 2211301 gcaaaaaaca cgatcatggt cggcaatatg aacctctttc ctgatgaaac aaatcgcaaa 2211361 gggatgtttg accggacacc tgatgaacac taacactgga ggttttacag catgaaggca 2211421 gtaacgtatc aaggcattaa aaatgttgtt gtcaaagatg tccccgatcc aaagattgaa 2211481 aaatccgatg acatgattat caaagtcacc agtacagcca tttgcggatc agatttacat 2211541 ttaatccatg gattcattcc gaatatgcaa gaagactatg tcatcggcca tgaaccgatg 2211601 ggaatcgtcg aagaagttgg ttctggggtg actaaactaa aaaagggaga tcgggtaatt 2211661 attcccttta atatagcatg cggggaatgc tttttttgta aaaaccagct ggaaagccaa 2211721 tgtgatcagt ctaatgacaa tggggaaatg ggtgcttatt tcggctattc agggcaaact 2211781 ggcggttatc caggcgggca agctgaatat ttaagagtgc cgtttgcgaa ttttacccat 2211841 tttaaaatcc ctgaatcttg tgaggaaccc gatgagaaat taagcgtgat tgccgatgcc 2211901 atgaccaccg gcttttggag tgtggataat gccggcgtaa aaaaaggcga tacagttatc 2211961 gttctcggct gcggaccagt cggcctgttt gctcaaaagt tttgttggct aaaaggcgca 2212021 aaacgcgtca tagcagttga ctatgtaaac tatcgcttac agcatgcgaa acgtacaaac 2212081 aaagtagaaa tcgttaattt tgaagaccat gagaatacag ggaattattt aaaggaaatc 2212141 acgaaaggcg gagcggatgt agtcattgac gctgttggga tggatggtaa aatgagcgat 2212201 ctcgagttcc ttgccagcgg cttaaagctt catggcggaa cgatgagtgc attggtcatt 2212261 gcttcccaag ctgttcgcaa aggaggaacc atacaaatta caggtgtgta tggaggcaga 2212321 tataacggtt ttccgttagg agatattatg cagcgaaacg tcaatatacg ctctggacag 2212381 gctccagtga tccactatat gccgtacatg tttgaactag tatcgacagg caaaattgat 2212441 ccgggagatg ttgtcagcca tgtcctgccg cttagtgaag ccaagcatgg ctatgacatt 2212501 tttgattcaa aaatggatga ttgtatcaaa gttgtgttaa agccttaaaa aacggaggtt 2212561 acagaaatgg aatacgcctt acacgaagtg cttgaggttc aggaaatgac tgcatttaag 2212621 acactttgtt tgacgaaatc taaaacaatg aaagcactgg tatctgatcc gaagctgaaa 2212681 gaaatcatgc agcaagatgt tgatatcacc acacgccagt tgcaggaatt tgcctctatt 2212741 ttatctaatg caaagcaaga atgaggagat gaataaatca tgaatcctat catagaatat 2212801 ctgactggca tgaatgttct aacagaccaa atcattgcta tggacttatt aatttcagca 2212861 aagaacggag tcagaaatta tgcgatggca gccactgaag ccggaacgcc tgaagtaaaa 2212921 gaggtcctta tccgccattt ggaagaagca ctcgatatgc acgaacaact ctcaagctat 2212981 atgatggaaa aaggctggta ccatccttgg aaccctgacg aacaagtcaa gctgaattta 2213041 aaaaatattg atacagccat tcaattgcca accctttaac atacaatgac tgatttgctg 2213101 aggaacagta ttgattggcc acaactgttc ctcagcttca aaatgagcac tgtttgttcg 2213161 ggtcctatga ccgtaaatag attaaccgct tttctccatc tgatctccga taatgtttgc 2213221 aaattctcca atccaaataa ggaatcgtaa ccacctcttt ttatgcgatc tcttgatgga 2213281 gaaaacaggc cagaaacaaa atccttcgtt tttgacctgc cctcttcaca cgcaaagaat 2213341 gctaccttct ttgctccact gatccgtgaa gactttccgt tttaggcctg cttttgagct 2213401 ttgcctcatt ttcacgcaat ttcccatcat aatctttaat ttttgtgtct aatctcttaa 2213461 ttgtttcatc aatttctttc cgcttctcta tcagccgctg tcgttcgtca gccaggatat 2213521 tttttcgagc ttctaccgta cggtcacctt cggtaaataa tgttgtatat tcaattagcg 2213581 cttctatcga tagtcccgca tttcgcatgc atttaatgaa ttcaatccat ttgatatctt 2213641 cttcatcata gtcgcgaatg ccgctgtctt ttcgttttac aggcgggatt aatcctacac 2213701 gttcgtaata tcggagtgtt gcggctgtca ggccaaactg ctttgccacc tgagcaatat 2213761 tcatgatctt cacctctcta tcctgtatgt tgtgaaggta acacttaaag ttaactttaa 2213821 gtcaagctca aaacaagtgg ttagctgctg aatctgggtt tatatattcg ggacttgcct 2213881 taaagcacac tttaaactct atacttctcc atgcactaaa aacagtgtag ttggagggat 2213941 tgctgaatgg caaataaaca cactgccgga agagaacaat taggagaatt tgcgccaaag 2214001 tttgctgaac ttcatgatga tgttctattc ggtgacattt gggcaagaga agaagaactt 2214061 tcatcccggg atcgcagcat gattacagtt tctgcattaa ttactgactg tttctcagct 2214121 tataaatcag gttcatttta aatggttttt ttaaaaaacc cttgccttaa agcagacttt 2214181 aaggtttatc gttatgttga agacaccata aaacataaat aagtgcatgt ttttatttac 2214241 aacacttatg atgaagaaag gataggttcg tatgtgtaat caacatcaaa cccgtgtatt 2214301 aagcgtgtca catgcaaaag ccaaatttga acaaacgacg attgagcgaa gaggattacg 2214361 gccgcacgat gtcttaatcg atattaaatt cagcggcatt tgccattcag acattcatag 2214421 cgcttttgat gaatggggcg gtggcatctt cccaatggtg cctggacatg aaatagccgg 2214481 tgttgtaaca gccgttggaa caaaagtcac caagttggct gtcggggacc gcgttggtgt 2214541 cggctgtttt gttgactctt gcggagaatg cgaatactgt ctcaacgcag aggaacaatt 2214601 ctgcacgaag ggtgttgttc aaacgtataa ctcagtagac tacgacggaa accccactta 2214661 tggcgggtac agccaaaaaa tcgttgtcac tgacagattt gttgttcgca taccagatcg 2214721 tttggaaatg gatgttgcca gtccgctgtt gtgtgcaggt atcacaacgt attccccgct 2214781 gaaacactgg aatgttggcc ctggtaaaaa ggttgcgatt gtaggcgtag gtggccttgg 2214841 acatttggca attcaatttg cacatgcgat gggtgcagaa gtaaccgtcc tgagccgttc 2214901 catgaataag aaagaggaag ctctggaact cggtgcaaat cattactttg caacaagtga 2214961 cccagccaca ttcactgcat tggccgggcg ttttgacgtg atcttaaata cggtatcggc 2215021 aaatctcgat gtagatgcct atttatcaat gcttcgtata gacgggacac ttgtaagcgt 2215081 tggagctcct gccaagccgg acacatacag tgtgttttcc ctaatcatgg ggcgccgcag 2215141 cattgcaggt tctctagtcg gcggaattca agaaactcaa gagatgctgg atttcgcagc 2215201 tgagcatggc atcgaaccta aaatcgaagt catcggagct gaccaagtgg acgaggcata 2215261 cgaacgtatc ctccgaagcg atgtccgtta tcgatttgtg attgatattt ccacattgta 2215321 ataggttagt ccttatatgg gctgccgctt ttattgaaac tcacgaaaaa tgatctcttt 2215381 aagcaaatat tttgaaggcc ggtcaatctt cctgttattc tatgaataga gagttattag 2215441 gagggttttt tatgagcaaa aaaattgcag ttcttgttac agaccaattc gaagacatcg 2215501 aatatacaag tccggtaaaa gcatacgaag aagctggcta cagtgttgtg gctatcgatt 2215561 tggaagccgg caaagaagtt accggtaagc atggcgagaa agtaaagatt gacaaagcca 2215621 tctctgatgt ggatgcaagt gactttgatg cacttttaat tcctggggga ttctctccgg 2215681 atttgcttcg tgcagatgac cgtccgggtg aattcgcaaa agcatttgtc gaaaacaaaa 2215741 aacctgtttt cgcaatttgc cacggcccgc aagtactgat tgatacggat cttctaaaag 2215801 gcaaagatat cacaggctac cgcagcatcc gcaaagattt aatcaatgcc ggtgcaaact 2215861 acaaagatgc agaagtagtc gtcagccaca acattgtcac aagcagaaca cctgatgatt 2215921 tggaagcatt taaccgcgaa tctttaaact tgttaaaata acaagaaggc acagactgtt 2215981 cgggtctgtg ccttttttaa aattaagact ccttcgttac attctgaaag acagcagtcg 2216041 cgtcccacac attcaagcca aattggcctt ctgaaaatac ggaatcatgt gcatcaatca 2216101 caagacgatc atctaaatag attttaaagc gatcgccctc ggcctctgtt ttcagatgat 2216161 actttttatt aacgtctatc ggtgttttgt attcagcaat gacagaagca gcaccgttct 2216221 caaatttaaa gaatttcact aggtcatgct tcgcatccac attggcaagg taaccgtttt 2216281 tggcatcttt gtcagagcga aacattagtg ctcctgcccc tcttccgttt ccatccttaa 2216341 tggtgatatc agattcataa gtgaagtctg acccggatgc tgaagacaag ataaaggaat 2216401 cgccgtccga cctcccttgt ttcccctcaa ttgtgtctgc ccacgtgcca tttacagtcg 2216461 tccagccagt catattggac ataaaaggtg tcgttcccca tacctttttt aaagggtgta 2216521 tcgttaaaga ttttaccttt acaccgccat ttgcagcata taattcaagc cctttgcttg 2216581 atcggtctgg gagaataata tccgttatga cctgctttcc gtcattccca aatacttcaa 2216641 ccgaggagcg gtcaacaaaa atgcgcaact taaccttccc atttaccggc ttcaacgggg 2216701 ctgtttcttt tccggtgtta aaggccggat taaaggtgtc gttgcctgac tcgctccggt 2216761 caacgaacaa tttggcgttc cttcggtcat agccgacctt cgtaaattga ttttcacctg 2216821 ttcggacctt aaaaccaaat tcagcagctg aaccagggct tactttaaat tctgcattta 2216881 tttcataggc atctccagat tgccccgcta acacattatg acttgcaggc gatatggtca 2216941 gattcttcca cttcttagag gttccgcgaa tggtttccag ctctttcacc ggtgtttgga 2217001 ccactctaac cccttcggta aacgctttca attttaactc tcttggaatg gacgttgcac 2217061 ttctccatgg ggatgtcgga acatcattcg catattgcca attgctcatc caccctaacc 2217121 atagccggcg gctgtctgtg gatggaatat cagaccagga tacagccgca taaaagtctc 2217181 tgccgtaatc cgtccagaga actttgtttg gcgggttttc atttttaaaa tgagttccat 2217241 caaagtcccc tacaaaatat tgcatgcctg atcctcccga gaccgctccg tttccgacac 2217301 tgacctgcat gacccatttc ttttgattcg gattgccgtc taccggaagc tcaaataaat 2217361 ccgggcattc ccatactccc ccgtggcttc cttgatcctg tccaaattca cttgcatacg 2217421 tccactgctt cagatttttt gatgtataaa tgaggattcg gtcaccggcc gcaagcacca 2217481 tcacccactt tttttctttc tcataccaaa agacttttgg atcgcgaaaa tcttttttac 2217541 ccgggtttgg aatgacaggg ttgccagcgt acttcgtcca tgttcttcct ttgtcgttgc 2217601 tataggcaat actttgcact tgatggcctt cccgatcctg tgtataaatg gccacaagcg 2217661 gcttctcttt gcctgtttga aaaccgcttg tgttattttt atctacaact gcgcttccag 2217721 aaaagatcgt gcctttttca tccggataca gcgcaacagg aaggtgttcc catgtaacca 2217781 aatctttgct gacggcatgc ccccaatgca tgggccccca ctgaagcccg tatggatggt 2217841 attgatagaa caagtgatat tccccagcat aatataccat tccgtttggg tcattcatcc 2217901 agtttgcctc cggtgtgaag tgatattgag gacggtaatc ctcatcatag tagcttgaat 2217961 cggctgcatc tgccgaaaat gccatagtca acagcagggt gaacatgatc atgacttgaa 2218021 tcagtctctt tttcatttgt tccttcgctc ctctcttcat gtttgaacac tttcaaaaga 2218081 gactgctgcg caagctggtc cgtttctggc aattctcctc tgtttcactg ttatccgaat 2218141 gatttatata tgaaaagact gctgcagttt ctctctcttt ccttcacaca ccttatgcta 2218201 agaatccagc ccaatacccg agaatcccga tgacaaagat gccgcaaata atgagaagtg 2218261 gattcacccc tttgcgaagc atccatgcca ccaataacgt taatccgaga ggcagcgccc 2218321 ccggcataat gctatctagc acgttttgta ccgtttgaac atctactttt ccgctttcat 2218381 ccttaatcct ggatacaacg attggaatgt tgatggtggt ccatttggac acgagagccc 2218441 ccataacaaa taacccgaga atcgaagcgc cctctgtaag cttttgaatg cgattccccg 2218501 ctaaatcctg aagaatctcc attcctttca catagccata ctttaatccg taatattttg 2218561 tgcttaatct tatggcattc agcaagaaaa agaatagcaa aggaccggca atgtttcctc 2218621 ctaaagcaag ggaggctcct agcgcagcta agacaggacg aatcgttccc caaaaaattg 2218681 gatcgcctac gcccgctatt ggtcccatca aaccgatttt cattccgctt atcgcttttc 2218741 cgtcaattcc tttattgttc gccatttctt cttccatggc tgccgtcacg ccaaatatag 2218801 gcgctgtcag ccacggatgt gtattaaacc attccaaatg ccgctgtaag gcttcgtttc 2218861 ttttcgctcc gggaccgtac aattttttga tcgccggtat catgacataa caatatccca 2218921 ttgcctgcac acgttcgaag ttaaaggaac cgagtaaaaa atttgaacga ataaacatgc 2218981 tgaaaatttc tttcttcgtt aatcgttttt ctttctccat tttttcttcc ccctcatcgt 2219041 ttaggcatca agatcatcat catcgtcatc ataaacagca acactgccac tgtctgatgc 2219101 ggccgcgact gctccgtgag cgctttgttt ttgcatcacc tgctggtata aaagcgccag 2219161 acagagacca agggctccaa atcccactaa gttaaaatcg gtaaacgccg ctaataagaa 2219221 accaatatag aaaaatggct ttaaataagg aatattcatc atattgatca ccatggcata 2219281 cccgacaacc acaataatgc ctccgcctat ttgcagtcct tttgtaatga catcaggaat 2219341 atttcccagg aacgcctgaa cagcgctgac actaattaaa gcaacaatca atgtaggaat 2219401 catgacgcgc aaagcttgaa acaccatcgc ggtaatatgc ataatttcaa ttccttttat 2219461 atttcccgct tttgcatatt gatcagcgcg gtggatgaaa aagacagtga tcgtccgaac 2219521 aaaaatcgtc agcgcctgac ccgcagctgc taaagcaaca gcgacagcaa tcccttcgcc 2219581 aattccttga tcagcggtaa taactaaaat ggttgagatg acagaggcga tcgctgtatc 2219641 aggtgccatg gcaagcccga cgttcatcca gccgagcgcc atcagctcca gtgtgcctcc 2219701 aagaataatt cccgttttta agtccccgag caccaagcca accaacgtac aggccactag 2219761 cggccggtgt gtctgccctt catccaatac acttgcgatt ccggtgattg ctgcaatgat 2219821 taacaacaaa ataatttgta atgaagacat attctcatcc ccttgattat tttgttacgt 2219881 tccgtaaaat ctgtacaaaa tcctcactgg catctgaagg cagctgcctc aattccagtt 2219941 tcacgccctt gtcacttaat gtttcaaatg cctttatatc ttgttctgtg acactgactg 2220001 attttgtgat ttgcctgcga tgattttcaa aacgcattcc cccgacgttt acggttttga 2220061 tcggtacacc tgcttctata agagatacaa tatcggacgg attttcaaac aagagcattg 2220121 ccgttacccc ttcgtagcgc ggactatgaa atgcttttgc cattttagaa accgagacgg 2220181 cactcgcctt tacatttgaa ggcgcaacag aaaggatcag cgtttttctc atttcgtcct 2220241 gagcaatatc gtcggagaca acgatgattc ggtcggctgc atggactttt atccaccttg 2220301 tcaggatttg gccgtgaata aagcggtcat caattcttgc taacacaatg ttcatcataa 2220361 ttcatcctct cttgtatctt gattggctgt ttttactttt tctaaatgtt cactgcacac 2220421 ttgaaagctt tgctgactca ttgcttttaa gttgttcagc aaatctttga gagccagatg 2220481 ttctctcagg cttaatacct ccagcagaat cggcaggttt acgccggcag ccatatccat 2220541 tctttgatcc tcagcaataa aggaagctgc cgcgttatat ggcgtccctc caaaaatatc 2220601 gactaaaaaa agcacttcat gttcttccgg gatatccttg agcgcctgat gatatttttc 2220661 ttgcagcgtt tgtattcctt cccctttgaa aaacggcact gcaatcaggt tattttcttc 2220721 accgaatatc atccctgaag actcttttaa tgctatggga aaatctccat gaccgctgat 2220781 aataactgaa atcatatcta ttgctccttt cctgttttgt acatccatat ataatgcaag 2220841 gatcgtgcca acacagttgt gttaagcgtt ttcattgtta tttcagccaa tagcaatttg 2220901 ttgttgaaac acttaaaacg aaaaaaataa acctgtatta aaatggtgtt ccatttaata 2220961 caggttcata tgaaaaaact gtttttaaaa cagctggcca tgcacttctt cagcaaatat 2221021 ggcggctata aataattttt catcatcact tatgcgaagt ccgagctttt cttcataagg 2221081 ggctaatgtt cgctctgtca cgtacaccat ttccttcagc tgatcattga tctcttcttc 2221141 ctctgagaaa gcgatcggat tctgcttaat taccctttca aaggcgaaag ccgtgtgcat 2221201 aatgactttg atcaaaaccg cattattgaa aatgaccccc agctcatcct gaacggtttg 2221261 cagccactcc aataacatgt cgatcacatg gtggggattc aagaagacaa ggtatttttt 2221321 caggctatcc tcgcaaagct ccctgacaat aatatttgct tcgttcaatc cattgctcaa 2221381 ggagatgctt ccttttgtaa tcgcctgttg aatcagcttc tctccctccc cttcaattaa 2221441 cacttctaaa gatacatgcg gagcattgat tttagggtct ttcgttccga ctgtcgcaag 2221501 gatttcatac tctttttcga tttcttttat gctgttggcc agcttaatcg atgatacggt 2221561 caatatgtga atgggggtat cggaggcctt gtttacgatc gtggttagaa tgtcttccag 2221621 ctttttggcc gttccgctac ccgtcgtgca gatggatacc aatgccttct ttttgccgga 2221681 tgccgctggc tgacgctccc acaactcgat aaaatccttc gtgaccgatt gatagatcgc 2221741 atgcaaattt aaattcaaat agttgacctt tctgacagca tccagcacca ttgaagtcgt 2221801 aacattgctg atcgttttaa tagaaatgcc tgtcttttcc tccagcctgc tttccagcat 2221861 tgcaagcgac cccatatcta ccagcattaa aacaccttca ccttcatcaa cctgtttcat 2221921 tttttctgct acgcattcaa gaatgtccga aggtgaaaca gtaagcggca tgtcaactgc 2221981 tgcaatcggc gtactcccta gcagttctgt cgcgacttca accattgaac tcgccgtgct 2222041 gtttccatga gctgccacga taataccgac tcttttgttc tcctttaacg atttgatgga 2222101 atgaattaac atcgttaagt agatgacttc tatttcagga atagccactt taaaatattc 2222161 ctgaatttta tctttaaaaa tcatcgccac ccgatattct ttcacatggg tatcacgaat 2222221 ttcatctgtc tcctgtgtat tcaaaacatc aatttgcttt cctcgcttta aaaatgcgtc 2222281 aatatgcata ctcaagaaat aaataaactt acggtcaaat gtgcaatcca gctcatgttc 2222341 agctatttct tttaactgtt ttgtcatttg aatcacatcg tcttcaacga atgtcagcag 2222401 gttgtctttt tgaaaagctt gatgatgaaa aaaacttctg acatgcaaat ggacatcagt 2222461 caagatgtac tggttaatat cctttttgga taaaccttct ttcataagcg ttttcacttt 2222521 ttcctcaatc aaatgatata agttaaatga gaggtcttcg tcaatttttg ttgtttcatc 2222581 ttctacaatc ggagagataa tcgttgtaat attgacatat tcagaaatgg ctttgcttct 2222641 ttgcatgttt ttgctgctgg acatccattc ttgcttgatt tcatcaggca gatcgcgaac 2222701 agtcagttca ataacttcat ttctgtcaag gttatgcaaa aatccgtgtg cgcaaactaa 2222761 ctgaacattt gatttcagct gtccgacatt cccaaatttc gcagagtgaa taagcgcatt 2222821 atagacatcg atatgcacac tcagattctt cttaattcgc tctgcttctt tccctaataa 2222881 aaacgtcgtc agatccactc tttcattaag cgatcgttct tcaagcgaag gaatatgaat 2222941 ggtcattggg attcttcgca aaaacgtttt caatagtgca gaactcggat tttctgtagt 2223001 cgcacaaata aacaatacgt tcgatgttcg tttatgttca gattctccaa gcctgttata 2223061 agaaccgctg tcaataaaat aaaacagcat ttcttgtccc tcgggaggga gacggtggat 2223121 ttcatccata aaaagaatgc ccccattggc ctgttcgact aaacccgcct tatcctcggc 2223181 agcacctgta aatgaacctt ttttgtgtcc gaataattga gaaagcaata attgagggtt 2223241 gttgtagtag tctgcacagt taaatgtaat aaatggtgcg ccggccttca atatgtcaga 2223301 gtaaatggca aactggtaaa ttcggttcgc aaaaagggat ttaccggaac cagtcggccc 2223361 taggaggagc atatgcagac cgttcggcgg ataaaagaca gctgcttttg cctgggagat 2223421 cgctttcttc aaactccctt ttgcccctat cataagctct aggggattcg tggaaatgtg 2223481 ttgatgattt tgctttgaat ttccggaaaa cgcctgaagg tctttcactt ccatcatctc 2223541 tgtatcccat ttcttgttga ataatttttc tgctatctcg actgggatgt atcttacagg 2223601 aaatgtttta attttgatga cctttttgga ccggacgaga ttgttcaatt caaagctgac 2223661 attggaccgc tccattttca gctgctcggc aatctccttt gctgaattcc cttgtatttt 2223721 taaaagatga tctaaggttg aatcatgaaa attatgcttg agctgatggt atattttatc 2223781 tattcttctc acgtctatca tcctttgtcc ttattagata agccattaac aagaatattt 2223841 cgaaacttta tagtccgcgt tgagatttac acgtttaaaa aggtctctat agcagattga 2223901 caaagctggc ttttatgcgt atatgtttac atgttgaatc atttgcacct catattagta 2223961 tgatagatgc tcagttctgg agggccagtc cccttcaaaa gtaataatca gtaaacagtt 2224021 tatcattctc ggggaatgta atgatgtcaa aataatcaat gacaaaaaat gaatcttata 2224081 gatcatgaca aattacccaa atataacccc ttaagttcgt tcacaactaa aaagacggac 2224141 actctatgtg accgccacag tattacaatt tgcaaaactt cgtcattttt gcaatccaca 2224201 ttggaggtta aggaatctgt aagcttaaaa actttatctc cgatcctatc gatttgatcc 2224261 ccctgccggc ctcaatcata gtgggtatgc aattatacaa atcgttaccg attaaaacta 2224321 gcctgtcaga ttgtccaaat gactttcctg ttttactctg ctattcaggt agaatcacga 2224381 gtgaaaaata gagccacaag acatgtaaca gcacttaaaa tagttttaaa atttaaaaat 2224441 aaaagtatct attcttttaa atgttataat atccgataaa actttactca tctttttatt 2224501 actggaggaa aataaaattg ataggcaatt ctagcaaaga caattttggc cagcaacaga 2224561 aattgtctag aggccttaaa aacaggcata tacaattaat ggcgattgga ggtgcaatcg 2224621 gtacaggttt atttttaggt tcaggtaaat ccatccattt tgcaggacca tccattttat 2224681 ttgcttactt gatcaccggc gtattttgct ttttcattat gcgttcgctc ggagaactgc 2224741 tcttatcaaa tgcgggatac cactcttttg ttgattttgt aagggactat ttaggaaaca 2224801 tggcagcatt tatcactggg tggacctact ggttctgttg gatttccctc gcgatggctg 2224861 atttaacggc ggtcggcatt tatacgcaat attggcttcc cgatgtgcct caatggctgc 2224921 cgggtcttct tgcgcttatt atcctgctga tcatgaacct tgccaccgtt aaacttttcg 2224981 gagaattaga attttggttt gcattgatca aagtcattgc catactggct ctgatcgtaa 2225041 ctggtattct cctgattgcg aaaggttttt ccgcagcttc cggccctgcc agcctcaaca 2225101 acctttggag ccacggcggc atgttcccaa atggatggca tgggtttatc ctatctttcc 2225161 aaatggtcgt cttcgctttc gtgggtattg aacttgttgg actgacagca ggtgaaacag 2225221 aaaatcccca aaaagtgatc cctaaagcca tcaatcaaat tcctgtccgg attttacttt 2225281 tttatgttgg cgcacttttc gtgattatgt gtatctatcc ttggaatgtg ttgaatccaa 2225341 acgaaagccc atttgttcag gtcttctctg cagtaggcat cgttgtggct gccagtttga 2225401 tcaattttgt tgtattaaca tcagccgcat cagctgcaaa tagcgcttta ttcagcacaa 2225461 gccgaatggt ctattcactt gcaaaggatc atcacgcacc tggactatta aagaaattaa 2225521 cttcttctaa cgtgccaagc aatgcgctgt tcttttcatc catcgccatt ctgattggcg 2225581 ttagtctgaa ttatttaatg cccgagcaag tcttcacgct gattacaagt gtttcaacaa 2225641 tatgcttcat ttttatttgg ggcatcacgg tgatttgcca tttgaaatat cgaaaaacaa 2225701 ggcagcatga agcgaaagca aacaaattta aaatgccttt ttacccatta tccaactatt 2225761 taacacttgc atttctcgcg ttcattcttg tcatattggc actggcgaat gatacacgta 2225821 ttgctttgtt tgtcaccccg gtctggtttg ttttattgat tattttgtat aaggtgcaaa 2225881 cccgcagagg acataaggtg aaataaaaaa aagacaaggg atactcactc ccttgtcttt 2225941 ttatatgtgt caaacactaa attaaacttt ggtttcaaat ttcattcact tcatttaagt 2226001 gttaactcaa accagttttg atgccgaaac ctactaatat tattccggta attttttgaa 2226061 acactttctg gaacttcgag tttttcatcc atttttttgc gtaatcaata atataaacaa 2226121 gaaacaggaa ccacaacacc gctaataagg ttaggattga agctaaaatg atgagctgct 2226181 ggtttatatt tccgttcaaa ttgataaatt ggggcatgat tgtaacatac accaaaacag 2226241 ttttaggatt gagaatgtta ctgagtgatc cctgcataaa ggaagtttta taataacgtt 2226301 tcggagaact tgccatattt tttgcttggg attgcatgtc atctaacgaa aacatacttt 2226361 tagcaaaaaa actttttaca cctaaataaa ttaagtatgc cgctcccaaa tatttgatcg 2226421 ttgtgaaaag aatcactgac tttgcgatta ccactgataa tcctaaaatg gcaatcaccg 2226481 tccaaaagga aagtcctgtc gccaatccga gaatgttata acggccggct ttcggaccat 2226541 acctaagcgt atttttcatc acaagcatcg tatctgcccc cggtatgata accatcatgg 2226601 cagcgatcgg tatgtatgcg agtaagctgt gcattgttct ctcccccttt aaaaatcccc 2226661 tcaatcatat agtgactaca aaagtaacta cttataaaag tgtatcaatg cgtttggaat 2226721 aaatcaatat gatttgttaa aatagcgatt actaaggcag cgattgctct ttatattgga 2226781 ggatatatga aagaaaatat gttagacatt ttaaaaaacc tcaattttac agaatatgaa 2226841 tcgaaagcgt atttagcatt attgcaagaa tcacctttaa caggctatgc cgttgccaaa 2226901 aaatccggag tgccccgttc taaaatttat gaagtattgg aaagtcttgt cataagggga 2226961 gatgtttttg tcagtcatgg aaatacgcct cagtatgttc cagtccccgc aaaagaactg 2227021 attaaaaacc gccggctcaa agcggaagag cattttgatc aggctgagaa atattttgaa 2227081 aagttcgagc agaccgcaaa tgaccgggaa aacatctgga atatcaccgg ccgcagtgaa 2227141 attcttgaaa aggtgaaggc ttgtatctta tctgccaaaa aaagaatcct cttagaaata 2227201 tggaaagagg attttaagga gatagaagca gagctcaaac aggcggcaga acaaggcgtt 2227261 attgtcacca ttattgcgta cggagacatc gtatctgatt ttgccaatgt ttaccttcat 2227321 gatatgagca gtgaaattac agaagagtat gacggacggt ggcttgtcta tagcggagat 2227381 gattcagaag tagtagcggg cattgtctca cttggcaacg acagccgtgc tgcatggacg 2227441 atgcatgtag ggttagtcat gcctattact gaagtgatca ttcatgatct gtacctcatg 2227501 gaaattctga aaaagcatag agagctttta gaagagagct tcgggaaaaa tctcatccag 2227561 ttgcgccgta aattttctat tcactcagat ttcaaaaaac attatttgga ataatgtttg 2227621 tcatctctta ccccaaaaac aaggcttgta caaaacaagc cttgtttttt tatgcataaa 2227681 ccccccatgc tgatttactt ctctctttta aaaaatgtga ttctgcgcaa actatttttc 2227741 agcctgccgc gtctatccta ggtaacagcc tacgatatac gtatattcaa aaaggagccc 2227801 tttattgcaa tgaagaaaaa acaaacaaca aaagcgttgc ttgtcacatg cataactgac 2227861 cataagcaag atttctacag gttggctttc agttatgtga aaaatcaaga tgacgcatta 2227921 gatattgttc aggaatctat aaaaaaagcg ctgagctcag ttgaaacggt caggaaccct 2227981 gagacgataa aaagctggtt ttataaaatt ttagtacgga cagccattga ctttttgcgc 2228041 aaacaaaaaa agataagagt gatggacgac gaaacgatag aatttttaag caaaggaaag 2228101 gaagaccatt acaaggatac tgatctccat gaagcgcttg acgaattgcc gtaccgctat 2228161 aaaaccatta ttattttacg tttttttgaa gacctcaaat tagaagaaat tgcggaaatt 2228221 acaggagaaa acacgaatac cgtcaaaacg cgcctataca gagcattgaa gctgatgcgc 2228281 attcagttga cgaaggagga tctttcttaa tggataagag attacagcaa ttaagagaag 2228341 aatataaaaa tgttcagatt cctaaagaat tggatatcat tgttgaaaaa gcccttcagc 2228401 aagaaccaaa aaagaaaaga atcgttatgt ggccgacatc agcagcaatc gctgcagcta 2228461 ttttattcac tgcgcttgtt aatatcaacc cggacgccgc tcaggctatg tcaaagatcc 2228521 ctgtcatcgg caaaatcgtc aaagcgatca cctttattga aatcaaagag gaaaaagacc 2228581 aatcaagcat tgatgtcaaa acacctgctt tgtccgggct ttctaataaa gagcttgaaa 2228641 acagcattaa cgagaaatac ttgaaagaaa gccagcagct gtataaagag tttatacagt 2228701 ccacatccaa aaacaaaaaa gggcatctca gcatctacag tgattacgag acggtcacag 2228761 acacgccaga tttactctct atccggcgca atattgaaac aacacaagca tcttcctaca 2228821 cacaaagccg ttatattaca attgacaaaa agaatgatat tttacttaca ttaaaaagct 2228881 tattcaaaga tgagcgctat atcaaagtca tcagtcaaaa catcaaagaa caaatgaaac 2228941 agcaaatgaa ggaagatcca aataaaatat attggctcac tgacgaagat gcagaaccgt 2229001 tcaaaacgat tcttcctgat cagacgtttt acattactga agaccataaa cttgtgatct 2229061 catttgacga atatgaagtc gcccccggct atatgggcgt tacagagttt acaattccaa 2229121 ccggcgtcat ttcaaacttg ctcgtgggag aacgttatat tcgataaaat aaaaacatcc 2229181 atctaagatt atggatgttt tctctcttct ctattcgagg tcgtaacccc gctatcaaaa 2229241 acaacgagaa tatttgcata ctattggagg aatacccatg tatcacaaga cacagcatca 2229301 tcgatacatt cctggacttg atggccttcg ggctttcgcc gtcctgtcag ttatcactta 2229361 tcacctaaat ttcaattggg ctaacggtgg ttttatcggg gttgatatct tttttgtttt 2229421 atccggatat ttgattacat ctattctatt accggcatat ggaaatgata tcaatcttga 2229481 ttttcgggat ttttgggtgc gccgcattcg gcggcttctc ccggcagcgt accttatgat 2229541 cttttccact gttgtgtggg tcgtattgtt tgatcgagaa ctattgcaca ctgtacgtgg 2229601 agatgcgatc tcttctctct tttatatgag caattggtgg tttatttttc acaagctatc 2229661 atattttgat agtttcggtt ccccatcacc tctaaaaaac ctttggtcgc tggcgattga 2229721 agaacaattt tatatcatat ggccgatgtt tttagttgtt ggaatgtaca taatgaaaag 2229781 ccgcgccaga ttggctgcgg tgatatcatt gcttgtgctt tgttcagccg tgatgatgag 2229841 cgtactgtat gaacctggcg gagatccgag ccgcgtttac tatggcacag acactcgttc 2229901 gtttgaactt ctcatcggat gtgccttggc tttggtatgg ccgatgaaaa ggctgtcttc 2229961 caacaggctg ccaagcaaac tgaagcacac tttgcacgcc actgaatttt tggcattttg 2230021 tattttagtg ttgtgtgtct atttcacaga tgaatacgag ccttttcttt acagaggcgg 2230081 aatgctattc attagcgtga ctgccgcaat ccttattgca tgtgtttgcc atccgagcag 2230141 ctttttaggc aatctgcttt catggaggcc gcttcggtgg cttggaacga ggtcttacgg 2230201 aatttatctt tggcactacc ctgttattgt gttaagcacg ccagttcaag aaatcggaaa 2230261 ccctgttttt tggcatatcg tgctaaaggt cattgtgaca tgtatacttg ccgagctctc 2230321 ctaccatttt attgagaagc cgatacggac acagggattt aggtcatttt cccgccgtgt 2230381 ttttatacat agaatcaagg aatggaaaac gacatctgtc atcagcaaaa tgtcaattgg 2230441 tttcattatt ttcgctatac ttatttttgc aggcgggctg tcagggctag ccggcgagca 2230501 aaagcaccct accaaatgga cctatagctc acaagaaaca aatgctgaca ccagccaggc 2230561 ttctggggat aaaaagaacg ctgcagcaga taaaaaacac aatcctgaac aaaagacaac 2230621 agattccaat cagggtcaaa aggaaaacaa agatagtggg caagagactc ataaaaagaa 2230681 agacacgcaa tcccaacagt tgaaaaaacc agcagacact gcgaaagaag ttttagctat 2230741 aggagattcc gtcatgcttg atatttcttc acacctgcgt cagtcatttt caaatgtgac 2230801 gattgatgga aaggtaggga gacaaatgtc tcaagctttg gaactcgcaa gggaatacaa 2230861 gtcttttaat cagccgaaca aggctgtcat cattgagctt ggaaccaatg gctattttac 2230921 aaacagccaa atcgaacaac tgcttcaatc tttctcaaaa gctcatattt atcttgtcaa 2230981 tacacgggtt ccccgccaat gggaaagcaa ggtaaatgaa tctttgcagc aacaggccca 2231041 cgcacatcaa aatgttacgt tagttgactg gcatacagaa gctcttcagc atccggaata 2231101 ttttacccct gatggtgttc acttggttcc taaaggggca aaaactttga ctgctcttat 2231161 tgttcaggcg atgaaatcgt aaaaaagaga tcctatacag atcacttttt tactttagtt 2231221 tctgatcgtt gattatgtct tctttcagca aggcagccct tatgtttaca tgccgtttac 2231281 gtaagggtaa gccaaaattg aatggaggga tgataatgaa aggaaatgaa gaacatgaca 2231341 tccaaaaaga gttgaaacga tatgagcttt ttttcaaaaa acgatataag gttctttata 2231401 cagtaaacga ttttatcatc ggtgctatgt ttctcgttgg aagttttttc tttttttatg 2231461 accggttaat gtcggcaggg atatggctgt ttgcgatcgg aagtttgctg ctgttaatca 2231521 ggccgaccat tcggctgatt catgactttc attaccgtaa gcatgtggaa cagcaattca 2231581 agcatcaatc ttcaacagat gactgatctt aaggaataag aaagaacaaa atgccaaaag 2231641 cctgagtcga aaatcaaaaa caagactttc agactattta tttttaaaaa caaggtaaaa 2231701 agaactaaac ttttgcctct gcatgccgat atgaataata aggccggcgc gatactccct 2231761 ataacatcct tttcagtaga tttcattatc gtgccggttt tctcatatgc aaagcaatcc 2231821 cgccaatcag attggcggga ttttatattt tacattcctg tccaaacgtc tttcacataa 2231881 cgtctttgat cttgcagctt ttgcagccat acagctgatt cttcctgact tgctgctttt 2231941 tcagcttcat atgccaatcg caaagttctc tctacatcag gagccatttg cgatccatca 2232001 ccgcatacgt aaatatgagc ccctttttca atgagtgtca tcaatttctg cgtatcttgc 2232061 ttgagcaagt gctggacata tccttttggt tcgttttcga cgcgcgagta gcatcggcgg 2232121 attgtgacca aaccgtcctg ttccgcttga tccagctctt ctctgtaaag gtcgtcatgg 2232181 tccgggcggc ggcagccgaa gtataaaagt gcttcaccaa gggtgcttcc ttccttcttc 2232241 aaaaccgatc ttgcctgaat aaagcctctg aatggcgcaa ttcctgtgcc cggcccgacc 2232301 ataatcatag gcgtttcagg atcattcggc atctgaaatc cggactgcgg cgtacgaatg 2232361 aagcaagctg ctgcatcacc tgtattcaat tctgctaaat aattagaggc gacaccccgg 2232421 tattcacctc ggccgctcca tgctgaggct ttcacaactc ctaccgtcat gctcacgata 2232481 tttgcatgaa ctttcggtga gcttgaaatg gaatagtatc tcggttttag tgatggcaaa 2232541 agtgctaaaa accgttcaaa cggcatttcg caagcaggat aatcctctaa aaaatcaagc 2232601 atggtaagac gttttgcaag tacctgctct ttgtaaatgc catcatctga aacgagctgt 2232661 tccagctctt tttgatgcgg cggacaaact gtataagagg ccagctcccg aagctgaagc 2232721 cttgatgccg gttcctgcag ctctacatag gacgacaata aatccactac tttgattggc 2232781 cgatccatcg gcagatgagc catatgagcg cttccgctta cttttatcac atgattggac 2232841 tgcaaaccga atcggctgag aacccgctga acaagctccc tgctgttctt tggcaggatt 2232901 ccgatatgat cgccttcttt atatgtttta ccagccggaa tttccaattc aatatggcgg 2232961 gttgaacgcg tgctggcagc tgtctggagt tctcgattct ctaacacaat cccttcaaac 2233021 gcgccatatg ctttagcaac cggcgtttcc gtcgcttcac tgagaaaagt aatcgataat 2233081 gaaggcctgt cttctttctg ggctatttcg ttaatatcaa atgcgtccat cgtttccttc 2233141 cagaagcggt tttcccaaga ctcgcggtgg ctttcaaaat catcggcggc gtcaccttcc 2233201 ccaatcgctg ttaaacgcga tgcccccttt gctttcatca tgtcatcaat caggcgggga 2233261 atccgctgat acgtgctggc ccagctccgg tttccgcagc cgaataccgc ataggaaaca 2233321 cctttcaatt ggccttcctc aagctctttc agccactcta caaatccggc agcattatca 2233381 ggcggcgccc cattataaga agccgttaca atgacgactg ccccttcttc agggagcttg 2233441 ccgatataat catcaagcgg agccgtttca gctgtaaagc ccatctggcg gccttgagca 2233501 gccagttcac cggctattcc ctcagctgtc ccaagatttg aaccaaaaag aacaagtaaa 2233561 ggtgtgccgt gtttaggttt ggtttctttt ggctttgttt ctgctttgat gtctgcctgt 2233621 tcttttctct gtacattgat tgccgctgtt tttcgcggtt tcacagtaat tttaaaatca 2233681 tccggcttga tcgttaatgc ttctttgatt tttagttcgt agccagtatg gtttatcaat 2233741 tcaaaatgct ttaatacaag accgagaacc attgtcgctt cttgaagagc aaactgcatg 2233801 ccaatacaag cgcgctgtcc gtttccaaac ggcttatacg catggtgagg gatacttgaa 2233861 ggatcctcaa accgttccgg acggaaatct tccgcatccg gtccccaagc gttttgatcc 2233921 cggtgcagtt ttggaattaa aacagtgact ggctgccctt tgctgatcgg atattccccg 2233981 cctagaacag tatcctcctt cgcatataga gaaaaagccg gagctgttgg atacagtctg 2234041 agggtttcat ttaaaaccat ccgaatgtat ttgagctgct ggatttgttt atattcaggc 2234101 gtgtcatccg ttaacacgcg atccgcttcc tcctgagctt ttttcagttt ttccggatgt 2234161 gtaagcagac aataaatcgc aaaggatagc aacccgcttg ttgtctcatg tccagcaatt 2234221 aaaaatgtga tgatttggta tcgaatgttt tcgtcatcca gcgtttcacc cgttactgga 2234281 tctttggcat aaagcatgag agacaagaga tccttaatgt tttcatccgg attcgccttt 2234341 cgctccgcta tcattctatc aaccagggag ttcatgactt ctatatcctt ttggaactgc 2234401 agcttcgttt tcaccatcat tttatcttgc aggcccagtc ttttcgattg attcatcgcc 2234461 tcttttaagg cacggagcat actggtgata aacggatgct gtgaatcacg gtaaaagctg 2234521 ttgaatcgat agttaaaccc gcataaccca atcgtatcaa gcgtcagacg tgtcatatcg 2234581 tccgctacat caatttcttc attagggttt aaccggctcc acttttgaat cagctgggtt 2234641 gcgatatcca gcatcataga atgatagcct ttcatcgctt tttgactaaa actcggcagc 2234701 aaaatgcggt gggctttttg ccagttcggt tcgtgcgtcc agcttgtaaa taagccatct 2234761 cccccgaact cacgcacctt ttgcaagcct ttgccaaggt tcttgtcaaa gcgtttttca 2234821 tcacacactt cagccacaag attgtggccg gacacaaaaa cactggatac tcccggaaaa 2234881 tcaaaacgga aaatcggtcc caattcatca gctatccgcc ataaggattg agaaagctgt 2234941 tctttttcca gatgcggaag attttttaaa ggtccgtatg ttttgggctg aggtattgcg 2235001 cttgcctgtt tcattaacat ctccctttcc tatttttgtg atgaatgaag cttaatggcg 2235061 tcccagcagc attgttccaa ttcagtaatt aaatcagtgt ccatctctat atcacctgtt 2235121 tgaacgagct gatatatctt gagaaacgcc cctaatacaa tcgcaattaa cacattagag 2235181 ggcaggctgc gaatcacgcc ttccgctttt cccttattaa aatagtcatc aagcatttga 2235241 gtcagatttt ctatcatttt tttgcttgta tgatttaagt aatgagcgtc ttttttggtt 2235301 tcaagaaaaa aaagcgcata gtcgctctct ttcgtaaact gaacgagaca gcaaaatacg 2235361 tggtgaaagc cttctctgac aggcaattct gaaacgtctt gcttcagttt ttccgtaaat 2235421 cgctggatgc tttcttgaaa cagtacgtta acgagtgttt ctttgctgtc aaaataacga 2235481 tagatcgttc ctgtccctac atgagcacgt tcagctatca taggaatagt ggtagcgtca 2235541 aaaccccttt ccgtaaaaag tgagactgac gctttcataa tcatgtcgta tttactgctg 2235601 gatgcggata tcatgtaatc tgacaacctc cgattcgttt acggaatgaa tattcattcc 2235661 ttttgttcac aaagaatgtc tgccctgtct gatatcacct ctttgttctt tcttctgtta 2235721 taagtttata tgaaaaaaac tttttttaat ataaagtata tgcaaaaaat aaaaaattaa 2235781 gaaaatatac ccaaatccta atacgaggat cttggatata tttcccgaga aattttttat 2235841 ttaacagcca caatacatag acaggaagca cgcctgataa cagaaagatc cctgaaatgc 2235901 tggtctttca gcagttgaat atacgttttc tctttttcac cggtatttgt gtcaatactg 2235961 atataaaacc ggccgtcaat ttgaagcacc ctgtaaattt ctcttaatgc aagcctaata 2236021 tcggtgcagc tttgaaccgt atgtaaagaa aagactttat taaaggtacg gtcatcaaag 2236081 ggaatgtcct ctggatagcc atgaaaaacc tccccgttcc ccatgttctt tcgattcgca 2236141 cgtgatatct gtcttacctt tcgttttgaa ggatcaatgc tttttaggct accctttttt 2236201 agtttcttgg ttatgctttt aaagacagtg ccgtttccaa ttccaatttc taaaattctg 2236261 tcattttctt gtatatctat agagtcaatc atcatatgct caattgtttt ggttagctta 2236321 tatttccgag aaaataattt ccaaaaatcc gatcgtttat agagtctatt ttctagcatt 2236381 ttaaacacct gcttttggtt tcctatgttt atttattatc ttaaaaaaat aaacatcatc 2236441 ttcatttcta aaagtgaagg aaggtaccaa ctagacggca atgtattgaa aaatgtttca 2236501 atagaactaa actttttcat ttttttccga aaaaaaagca gaaaacataa tgttttctgc 2236561 cctctttcta atgccaatga taagggaata catacagcct ttgctgctgc attgccatca 2236621 gcctctgctg tcggaatgga tttccataac catgtttgaa ggaatgcggc atggacgcat 2236681 aaccatggcc aatcgacggc agtctttttt gataatcgtt catcatgcca tcacctgcct 2236741 cacaataacg ttgatttact atatgcaggc gcgcattttc ttgacagcta tttcgctaaa 2236801 cttggtcctt ctccattgta taatgcatca atagttccat tctaagcata tgccattccc 2236861 ccttcagttt ttttcgttgc ttttagcgcc agtttgttaa ataaagatgc tttaactgag 2236921 actctttcat ttcatcataa atttgttcaa tctgctgttc tcgttcgaat tcttccaggc 2236981 ttttaaaccg ttttttaatc gttaacgtta aaaagaatag gttaatcgtc atatcgctca 2237041 ccccctttca aagtccgcat caagcgaaat aacccgcggc acaacccttc tgccgcgggc 2237101 aaataaaaac cgcagacaaa agaagacacc aatgcctcta ctgcctgcgg ggagttgcgt 2237161 atgtccgact attccgaatt taatgcgtgc gataagcatc ggttaaggaa ggacacgaac 2237221 tcttccacag gctgaataaa ccatgaactt ttacatgtgt atcacgtaca ggttgacgtc 2237281 gttgtctcat tgtcattttg gttcagcctc ctttgctttt ttcttacttt gtaagtatat 2237341 ccaccaaatt ccattttgta aacatctttt tctaaaaatg gacggaaatt gtgcaaatca 2237401 tcgaatggat ttgcccgttg gtcatgacac ctgcttcatt tcttttctgg agcggtcttt 2237461 cttatgatat gcaataaaat aaatgagacc gacaaataca gctccgccga tgacattacc 2237521 gataaaagcc ggaatgatgt ttccgatgaa ctgcccccac gtgaatgagc ctgcaaaaat 2237581 ggcagcagga atcacaaaca tgttggcgac aacgtgctga aatccgatag ccacaaaagc 2237641 catgattggg aaccagatgc caaggatttt tcctgctgcg tcttgggcgc cgaaagaaag 2237701 ccacactgca agacatacaa gccagttaca gccgatggcg gaaatgagaa ccttgccaaa 2237761 gctcatatca agctttcctt gggcaacggc aatcgttttt tctaaataag gacctgtttc 2237821 agtcaatcca accaaatgcc cgaaaaagta agcaacaaac aatgcgccga ttaagttcat 2237881 aattgtgacg attccccagt taatcgctaa ctcttttact gatatttttc tcgaaaataa 2237941 cgccatcgca actgacatca tattgcctgt gatcagttca gcgccagcga gaacgacaag 2238001 gatcaggccg actggaaata ctgctgcacc aatcaaactg gacaggctcc cccattcttt 2238061 cggaagatcg ccaattaccc tgatatcaag caaataccca agcgcgataa atgcaccgcc 2238121 taaaaacccc agcacaagca gtgacggcag cgggagcttt atttttttca tccctgcttc 2238181 aattgctgct tccgctattt catccggttt tcgaaaagcc ataataaaac gcctccatta 2238241 cttcttcttt tctcacagtt atgcaagaaa ggcaataaaa aaggcagcac tcaaataacc 2238301 tgtgtcaaac caggcgtttg aatgctgcct aacttgtatg catacccata caacaatatc 2238361 aagcagtata taagatattg aaagagaata tatacagttc gtgcatacat tccattgctt 2238421 tagccttcta taactgtagc aacatcatat caaatgtgac aaatttgtgt caatgacaaa 2238481 tatactagct ttgcagagct tctttttgct catctatttt tcggtcaaaa acaaatacag 2238541 atacagcgat gttttcctca attttaatat cagaaaacaa atggactagc ttagctccca 2238601 taagttcctc cattccttcc ggtgtttgtt tggaataaag gtcttgaatt aggcttgtcc 2238661 gggccgcatg taccatctct cttccttcag gcgtgcgggc aataaactgc tcgcttgcac 2238721 tcagatttcc gtatagtgtt gaaactgcca tgttttctac aaatacagta tgaattctct 2238781 caggcccttt tccgaacaat tctttgcgaa gttttcgaat aatatcattg aattcatgaa 2238841 tttttttaga catgctgatt accccttccg atattgcctt ataaaggctt ttcccggttc 2238901 ccctcaggac atttcacttg gttaaaattt tcctgccata ttgtattata ataaatatca 2238961 cattataata aaagcagtgt tgatggattt gtaataggat cttgttatga gtctatcgtt 2239021 ttataaaaat caaggattgg tctgttagta agacttgcta gtgaactatt ccgccatgtg 2239081 tgtttacacc ttcttagaat taagggcagg tgtatctata catggctttt tttgacttct 2239141 tgaaagaaag atggagggga atatgaatat gatggacgtt aagtcgatca gtgtccgtgt 2239201 agacggaaca gaaattcaag cacgagcagg ggccacaatt ttagatattt taaatgaaaa 2239261 cggaattgag tacccgcaga tttgccacgt accagaggtt gacccgattc aaacttgtga 2239321 tacttgcata gtagaggcaa acggcaagct ggttcgttca tgcgcgacgg ttgcagaaaa 2239381 cgggatgtct attgatcttt caggaaatcg agtgaaagaa gcgcaaaccg aagcgatgga 2239441 ccgccttctt gaaaatcatt tgctgtattg tacagtttgc gataacaaca atggaaactg 2239501 tacgctgcat aatacagcgg aaatgatggg gatcgagcat caaaaatacc catacacgcc 2239561 aaaagaagat ccttcttgcg cggttgatat gtctcatcct ttttaccgct atgatccaaa 2239621 ccaatgtatt gcctgcggcc agtgtgttga ggtctgtcaa aaccttcagg taaatgaaac 2239681 actctcaatc gactgggaac gcgaacgccc tcgcgtcatt tgggatgagg gagttccgat 2239741 caatgaatct tcctgtgtca gctgcggtca gtgtgtaaca gtatgtccat gtaatgcact 2239801 gatggaaaaa tcaatgctcg ggcaggctgg ttttatgaca ggcattaaag aggacgtcat 2239861 ggaaccgatg attgatctcg tgaaaaatgt tgaaccgggg tatggcagca tttttgccat 2239921 ttctgaagtc gaagcggcaa tgcgtgaaac gagaacgaaa aaaacgaaaa ctgtatgtac 2239981 gttctgcggt gtcggatgtt catttgaagt atggacaaaa ggacgggata ttttaaagat 2240041 ccagcctgtt tctgatgctc cggttaacgc aatttccaca tgtgtcaaag ggaaattcgg 2240101 ctgggatttt gtcaattcaa aagagcggat cacaaagcct ttaatccgta aaaacggagc 2240161 ctttgtggaa tcttcttggg aagaagccct cgatcttgtc gcaagcagat taggatcaat 2240221 taaagagcag tacggtaaag gctctgtagg gtttatttct tcttctaaaa ttacgaatga 2240281 agaaaactac gtcattcaaa aactagcgcg tcaggtattt gaaacaaaca acgtcgataa 2240341 ctgctcacgc tactgccagt ctcctgctac agacggattg ttccgcactg tcggcatggg 2240401 cggtgacgcc ggcacgatta aagatattgc caaagcaggc ctggtcatca ttgtcggtgc 2240461 caatccggcg gaaggacacc cagtgctcgc aacacgcgtc aaacgggcac acaagctcca 2240521 cggtcaaaaa ctgattgttg ctgacctgcg taaaaatgag atggctgagc gatctgatct 2240581 gttcatcagc cctaaacaag gcacagacca agtttggctg atggctgtta cgaaatatat 2240641 gatcgaccaa ggctggcacg atcaggcgtt tattgatgag aacgtcaatt actttgaaga 2240701 ttataaagaa acccttaaaa cgtatacgct tgattatgca gaacgcatca caggcctttc 2240761 aaaagaaaac atcattcaaa ttgctgaaat gattcgtgat gctgacggca cttgtgtcct 2240821 ttggggaatg ggtgtcacac aaaatacagg cggttctgat acatcagcag ccatttcaaa 2240881 cctgcttctc gctacgggca actatcgccg tccaggtgcc ggcgcttatc ctctgcgcgg 2240941 acacaataac gtgcaaggcg catgtgatat gggaacattg cctggctggc tgccgggata 2241001 tcagcatatt acagatgaca aagcacgcgc taaatttgaa gaggcatatg gtgtcgagat 2241061 tgatggaaag cctggtttag ataatattca aatgcttcat gccattgaag aaggaaaaat 2241121 gaaagctatg tatcttgtcg gtgaggatat ggcactggtc gattcaaacg cgaaccatgt 2241181 gcatgatatt ttatcaagcc ttgatttctt cgtggtacag gacatcttcc tgtcaagaac 2241241 agctcaatat gctgatgtcg tcttgccggc cactccttca cttgaaaaag acggaacatt 2241301 taccaacaca gaacgccgtg tccagcgatt gtatcaggcg cttccgacgc ttggtgacgc 2241361 aaaaccggac tggtggatta ttcaagaggt ggcaaaccgt ttaggagcga attggaatta 2241421 cagccatcca agtgacattt tctctgaaat ggcgagtctt tctcctctgt ttgccaaagc 2241481 aagctatgag gtgcttgaag gctggaacag cttcctatgg ggcagcttca caggtgaaag 2241541 cacaccgctt ctgtatgaag acggatttaa tttccctgac aaaaaagccc gctttgccct 2241601 ttctgattgg accgagccag cggcatttcc ggaggaatat gaccttcata tcaataacgg 2241661 ccggatgctg gagcatttcc acgaaggaaa catgacaaat aaatcgaaag gcatccaagc 2241721 gaaagtgccg aatgtattcg ttgagatctc acctgagctt gcacaagagc gaggtgtttg 2241781 tgacggttcg cttgtacggc tcgtttctcc gttcggagca gtcaaattga acgcgctgat 2241841 cacagaccgg gtacggaaaa atgaactcta tttgccaatg aactcgacag acaaggagtc 2241901 agcgattaac ttcttgacgg gccctgcagc tgataaacgg acgaacacgc ctgcttataa 2241961 acagacaaag gtccgcatgg aagtgcttgg cggctgtgaa acagcgccgc ttccaaaaac 2242021 aaatccgcgc aacaaaaaac ggcatccgca aaacggagtc gaagcagaaa gaaaatggaa 2242081 ccgccctggc tatgtacatc tgactgatta aacgatagga ggaaaacgaa tggccactcc 2242141 gattacgacg atcaaaaaag aaacaaaaac agctgagcaa attaagcttg aaaaaataga 2242201 agaactgaaa gagctgctgg cggaaaatga ggacgccgtc tctaaaacga tgacgttaat 2242261 gaatgaactc aatgatcttg gaatttttga tgcggcaaca agcatgctca gagcgaagga 2242321 agacattgcc aagattgcgc ttggccaagt ttcccgcgag cctgtcacca acctcatcaa 2242381 cacgatgatg gccgccggag gcgcattgac aaaagccgat cctgagttta cagcaaagct 2242441 tttagaaagc gtaatggctg ggactgaaca ggcacaaagc tttttaaaag aagacaagaa 2242501 agtcgggatt ctcgacctgt taaaagcaat gaacgatcct gacatcaaca gagccgtcgg 2242561 gttcggcctt cagtttttaa aaggcatggg aaaagaactt cgagaacaat aacagaaaaa 2242621 cagccatctc tgatgatggc tgttttttta ttcgtcggct tcttccagac gcttcttgta 2242681 aataagtgaa cggtcagcgc aaaagaaggc accggctaaa aatacgcaat ccgctaaaaa 2242741 catcgtcgat ttctggccta atgttaagcc ttgatcaggg agaactgcgc ctatatataa 2242801 aaaagtgctg actgcaagca atgtaaaagc aaaatgcttg tagtcttctt ttaaagattt 2242861 cattctattt ttgttcaaaa gaatcacctg ccagattcat agtatacgac tattataata 2242921 taatccggcg gcttacagag aaagtaattc tatccatttg ttatatattt tcaagcgctt 2242981 ggccgatatc ttccaacaag tcttccgcat cttcaattcc tacagaaatt ctgatcaagc 2243041 cgtccgtaat gccgagctca agccggcgtt ctctcggaat agaggcatgt gtcattcttg 2243101 caggaacaga aattaagctt tcaaccgccc ccaggctttc agcaatggta aacagtttca 2243161 gatttcctaa aaacgcatca acccgttctt cactgccaat atcaaaggag atcatgccgc 2243221 cgaagcccgc tccttgcgtt tttgcaagct catgtccggg atgatttgaa gaaccagggt 2243281 aatataacgt ttggacagca gggtgattct caagaaagct tgcgattttc cgcgcatttt 2243341 gatcgatcgc ttccattctg agtcccaacg ttttgattcc tctcattaac agccaggaat 2243401 cttgagggcc gagcacgccg cctgtggagt tttgcacaaa atgcagctct tctccaagct 2243461 ctttcgaagc tgtcacaact aaacctccga cgacatcact gtgtccgcca agatattttg 2243521 tcgcactgtg cagtacgata tcagcgccta aagtaagcgg ctgttgaaaa taaggagtat 2243581 taaaggtatt gtctacgata agcagaacac ccgctttttt tgcgatatca gccatgagcg 2243641 tcaggtcggt gattttgagc aacgggtttg tcggtgtttc aatataaatt gcttttgtat 2243701 tagggcgaat cgctttttca acttcttccc tgctgctcgt atcaacaaat gttgattcaa 2243761 tgccaagacg gttaagcacc tttgtcatca cgcgatatgt tccgccgtac acatcatcag 2243821 tcaacacgac atgatctccg ctgttaaaca gcatcataac cgctgtaatg gcagccattc 2243881 ctgagctgaa cgcatagcct gcttccccgc tttccagttc tgtcacaagt gcttcgagag 2243941 cggttcgagt cggattggcc gttcttgaat actcgtagcc tgtatgctgc cctgctttcg 2244001 gctgcttgta cgtgcttact tgataaatcg gcacggaaac tgcgcctgtt ttctcatcac 2244061 ctgtgattcc gccatgtatc atcaatgttt ttttcttcat atcagatgcc tccttcgtat 2244121 atttgtttgc tgatatatcg atcgctgctg tcaggaaata ctgtgacaat gttagttcca 2244181 gcggatgctt ttttcgcttc ctccaatgcc gcataaagcg ctgcacctga agagcttccg 2244241 atcagcaggc cttctttttc tgccgcttct ttcacaagtc taaacgcatt ctcatctgtt 2244301 acggtgtaga tctcgtcaaa atggctctta tccatataat cggggataaa ctccatgccg 2244361 atgccctctg ttttatgagc gtggggctct cctccgttta aaatcgagcc caccggttca 2244421 acaatcaccg ttttgactgc tggatttttt tcttttaaga aggaagctgt ccctgcgaat 2244481 gtgcctcctg atcctgcccc tgcgacaaat gtatgaatat tcccgtcaag cgcttcccac 2244541 atttcaggtc caagcgtctt atagtaagtc gatggattta ctcggttttt aaattgcaaa 2244601 acgcaataag aattttcaat ttcagtctcc agctgaatgg ctttttgaat ggctccctgc 2244661 attccgtctt gacgcggtgt atgaatgatt gatgcgccaa gcgcttgcat aatttgctgt 2244721 ttctctctgc tgaaatgttc agggacacag aaaatcgctt tcagcccata ttttctggca 2244781 cttaacgcaa ggccgatccc tgtattgcct gccgtagctt ctataatcac tccgccgggt 2244841 ttcactttgc ctgaatcgag cgcgtcacga atcagcatat ctcccagtct gtctttgatg 2244901 cttccccctg gattcatcat ttcaagcttg gcatacaccg cgactccttc tggaacatca 2244961 aagttcttca agcggagaag cggtgtattc ccaatcagct cggtaatgtc cgtaatcact 2245021 gtcatatatg tcctcctcct taatagaggt tgtttttaga gaaaaacgga ggagaacgtt 2245081 ctccccgttt taatgaattc gtttgatcac ctttaacaca agctctgttg aatgaacagc 2245141 cgcctgctct aaaaattggt caaatgaaac atgtgattct ttgcctgcga tatctgataa 2245201 cgctctgatg acgacaaacg gcgttttaaa ttgatggcat acttgagcca ctgccgcagc 2245261 ctccatttca accgcgtaca gatcagaaaa tctcgcacgc acctcttcaa cccgcttcgg 2245321 atcgttcatg aaagaatcgc ctgttgcaat cgttcctttt gcaacctgaa tgccgtcgag 2245381 ttcagatacc gcttcttcag tgatgctgat cagcttttca tccgccgcat aagcagccgg 2245441 aagacccggc acttggccgt attcatagtc aaaagccgtt acgtctacat catggtggcg 2245501 aacgtcagtg gaaatgacga catcccctac attcaatgta tgatgaaatc cgccggctga 2245561 gcctgtgtta atgacataat caggcttgta acggtcaagc agaagcgtcg tgctgatagc 2245621 agcatttact tttccaattc ctgattttaa aagaatcact tcagttcctt catattcgcc 2245681 tgttgtaaat tcacagtgtg cgatcgtttc tgtttttgca ttttcaagtt tgtttcttaa 2245741 gatggtaact tcctcttcca ttgctccgat gactgctagt ctcatctatt cacattccct 2245801 tcactttacc gtttgatcgc ctccattatc cacacgaagt cgttttgctg agtgaatcgg 2245861 actgcaaaac cttcagctgt aaacatttct ttcaacgcat ccaatgtagg ataatgctct 2245921 gtctctaaat catttgcaag ctgataaaag ccttgagaac gggctttatc gatagcctgt 2245981 tgatacgctt gcgcattttc aaagacggta tcggcaaaca ctattttatc atgcaagtga 2246041 aggtatttgc catattgctt tatggcagcc cgcttttctt cgtcagtcaa atgatgaaaa 2246101 gcatatgaac tgacaatcgt atcagcctga aatggcggct cagggaatgt caggaagtct 2246161 ccatcaacga tttccgtcct gcctgagagc ttgtcagaag ccagtttacg cattgctgga 2246221 gaaggttcga ttccaaatac agttttgcct gcatcgagca gcttagctgt caaattcccg 2246281 gtccccgggc caaattctaa cacatgcgtt ccagattttc tgacgatggc atcaaggata 2246341 tgatcgtagc ctctgaacgc ttctttatac tgaatatcta aaccttgtac tgtttgatca 2246401 taagttgctg cccaatcttc aaagagaggg ataaattcac ggcccatatt tgtcacactc 2246461 catatttaat aattcctata agtatactat ggattaatga tggaacagtt cctataatac 2246521 cacatattct gaaaagcagg tactaaaaca ctttgtgtat tttatgccat ctcatattgc 2246581 gcattgaccg caaaaaagct tatacttcat atgacttgtg aaagctggag ggtcaagaca 2246641 tgaattttca attagatctg attaaagaca aagtggaatt ttttgaagcg gcttcattgc 2246701 aggagcttga aaagaaaatc aatacacaaa ttgaaaacaa taaagccatc atgctccggg 2246761 tgaaatctgt ttcacaccaa actcttgtgg cagaaggaag aatattgtac agcgcggtgg 2246821 ttcatttctc agctgaagcc taaaacaaaa gcagccggtt ttaacccggc tgcttttgtt 2246881 tattttagct tttctacttt tgtcggcttc cagccttttt catcgaccca tgtaatcgtg 2246941 acttgatatt tattcccagt cgccttgtcc aaaatcttgc ctttggcatc ctgagggctg 2247001 ccgttatttc caagccagag caccgtcatg ttatctgttg agacaccagt tgcgtacgaa 2247061 atggctttca gcatctcagc ccagtcttgt gagcttgaat cataagtagc ggcatgctcg 2247121 ccagtctgct cagttccgac tgctttccag tcaggatttt catacgtttt ttccacatcg 2247181 ctcgatgagc cgccttctgt tacttttgca tctttaagcc cgtcaccggc tgaatctgag 2247241 cttgaatctg aatcagagtc atctttttta gaagaagaat catctttttt ggaatcagag 2247301 tcagaagact tctcagaatc cttttcgctg tcagatgtat ctttcttgct gtcttttata 2247361 tcctcatccg atttcttttc cgtctttcct gaagccggag attcctgttt ttgcgccgtt 2247421 tcagaatcct tgctgacatc tttgctagaa ggactgttaa tgaagagatt cgctgctact 2247481 acgacaatta gtatggatac gattgcgatt aaaatgttaa gcactaaatt ggcttttctg 2247541 cgtttatcac gattttcata acgagattga ttattgctca ataattctgc actcctttat 2247601 ccctcttggc tcagcatata ttttaacatg tgctgagaag ttgttctatt tctgattgat 2247661 ttcaatttcg tgtacttttt taacaatatc ataaaacacc gaatttgtca gagccttatc 2247721 tcccggtgta tccatgtgta aaacaactag agcgtatttc ggcttatccg cgggaaaata 2247781 tccggcaaac catttttcgt agagcgtttc cttctctttt gaaagcttgc ctgtctgggc 2247841 tgtgcccgac ttccctgcta cagtatacgg aagatcttga aaccttctgc ccgttccgga 2247901 aggagattct actacccgcc gcagtatttt ttgaagctgc tgtgacgtat atttgtctat 2247961 cgtttcccct ttgagcttct gatctttaaa cgtaacgagc gttgtgccgt tcttatactc 2248021 aatttgttcg gcaattttca cctgccgttt ttctccgccg cgggcgattg tcgccatcat 2248081 attggctacc tccagcggcg ttacctttac atttttctgc ccgattgctg tttgcgcaat 2248141 ggcttttttg actgatttgt ctttttcatc cccccaaatc acgccgcttt tttcgttata 2248201 cagctggcgg aaatcggttt cgtggtacag ttttccctcc cagcctgccc gatcagtgag 2248261 agccagcttc tcggacatat cttcaataac cgagctgtct tttttcatta attgttctgc 2248321 aagactcgta aatgtgtaat tacagctttg ggcaaaactt tcatcaaaag acaaggtgcc 2248381 tttgtcgtcc cccggttccc cgtacaggtt taaattgcaa ttaaaggttt gactaggctt 2248441 caccatatta ttttcgattg cagctgcggc aatgactgtt ttaaaaactg atccgggata 2248501 gattggcgtc agcatataat tttgaagtgt gttttgccgg gacacgtctg catctggttt 2248561 gcttacaatt cccagaacac tgctattttc gatgtccagc agcacagctc ctcccttttt 2248621 cagcccctgt tcatccaata cctcctccat cgctttttga atgctttgat cgatcgttgt 2248681 tttgatctgg agcggataaa atgtattggc ttcagctgta tatttgacgt ccatgccaaa 2248741 caaagggttt ccttttccgt ccacatgata taaaagcttt gtgtcttgtt ccggaagcaa 2248801 aaactcgtca aatgtccgtt ctaaaccggt tgttccgatt tctgttgtaa tcggaaggct 2248861 ctccttgtca ggatatttct tgcgaagcag cgccggatct tggttcgtgc tccctatcgt 2248921 atgtgaagca aggctgggct tgtcttcatt ctccatatat acgccgtaaa tgccgggata 2248981 tttcaaagaa ttgatttttg tgatagattg ttttgaaagt gttttgattt tcttttgctg 2249041 caaaatgacc ggtttttttg cctgacctag tgtctggcgc aaatcatctt cagacatgcc 2249101 gaggatgtcc gcaacttttt tgatcggcca atcctgcgtc agcagaaaag ggaacaaaac 2249161 aaccgcaggc tcgctttgtc ctgtcagcgc ccgcccgttt cgatctaaaa aagagcctct 2249221 tccatctgaa atgagcactt cctccgtccg ctgtttcaca ctttcttgaa tcaaattaat 2249281 tttcttttta gaaaatgatt ctgtgaaaaa cagctggatt tctgcaagtc tcagcagaag 2249341 cagaaaaaat acaatcaaaa aagcgatgac tgccagcttc attcgtttcg atatcttcat 2249401 aaaaaaacac ctcacccaca ttgtggacga ggtgtttcgc tgctaaacag atattatgaa 2249461 attttcacaa ttttcacgag catttctccg cccggtgttt gtactgtgac ttcttcatct 2249521 acttttttgc ccaagaggct ttttgcgatc ggtgaatcgt ttgagatttt cccttcaaac 2249581 gggtcagctt ccgcgcttcc gacgatcgta tatgattctt catcaccgtc aggcagttcg 2249641 acgaaagtga cggttttacc caaaccgaca acgttagagc cgccgtcatc ttcaatgatt 2249701 ttcgcattgc gaatcatatt ttcaagagtc gtcacgcggc cctctacaaa tgcctgctct 2249761 tctttcgctg aatcgtattc agagttctcg gaaaggtctc cgaagcttct cgcaattttg 2249821 attcgctcta ctacttcttt tcgtttaacc gttttcaaat attctaattc ttgttcaagt 2249881 ttttgttttc cttctgcagt cataggaaaa actttctctt gtgccatgtc ccttcactcc 2249941 ttctggttgt ccctcaacat cttcgattat gtatgagagc ataaactaaa aaatacaaga 2250001 atgagaacac agggcagtcc tcgttcttct ctcccatata ggtactgttt atcttaaact 2250061 gaatcgtgtc gttctgcaaa tatttcgcgt ttataaacag ggaaagaagg gaattcgcac 2250121 attcccttcc tgcctataca taatatggtc agagttattt atgtctatgc tatggtatta 2250181 caaaatcgcg ttttgttcaa gaatggtttg aatttttgtg accatcagat caattgcgac 2250241 gtgattctga ccgccttccg ggataataat atcagcgtat cgtttcgtcg gctcgacgaa 2250301 ttggttatgc atcggacgga ccactgacac atattgttca atgacagaat caatagagcg 2250361 tccgcgctca ttaatatctc tcataatccg tctgatgata cgcaagtcag cgtccgtatc 2250421 aacataaagc ttgatatcca tcagatcacg aagccttttg tcttcaagaa caagaatgcc 2250481 ttcaaggata ataacatcct ttggctctac gtgaaccgtt tcttctgaac gtgtgtgaag 2250541 cttatagtca taaatcggct tttcaatcgg gcggtaattc aatagatctt gaatatgctc 2250601 gattaaatag tcattatcaa acgcaagcgg atgatcatag tttgtgttca gcctttcttc 2250661 aaacggaaga tggctttggt ctttataata aaggtcctgc tggatcatta aaattgagtg 2250721 tcctttaaac tgttcataaa tggaccgtgt gacactcgtt tttcctgaac cggaacctcc 2250781 tgcgattcca atgactactg gattcttacc catgggctgt tacttcccct ttctcatcat 2250841 gttgctcgga taaatctttt tgtctagttt gaatttgaca atttgcaggg gatggcgggc 2250901 agcatctagc tcatttccgt cttcgtccca aatggtttca atcgtatgtg taaagttttc 2250961 gatttctgga ccgaaaaatt ccacttcgtc gccttttttg aagaaattgc gctgctgaag 2251021 cgtgaccatt tgtgtatctt catcataatt cagcactaag ccgacaaaat catatgtcgt 2251081 tttcttggcg tgttcgccga acatttgctc ttcatagcct ggcgttcctt caaagaaagc 2251141 tgtcgcagtg tccctgttgg cgcacttatc aagctcttca agccattctt tttgaatcac 2251201 aaagttttct ggatcagcgc aataagcatc gattactttg cggtatacgc tgacaacagt 2251261 tgctacatag tgaatggatt tcatgcggcc ttcaatcttt aagctgtcga tccccatttc 2251321 aatcattttt ggaatggatt caatcagctt caaatctttc gggctcatcg caaatggtgc 2251381 atcttcttca ccatacaaag caacggcgtt ggcaccgtct gtttggtaga gatcataatc 2251441 ccagcggcat gactggcagc agcctccgcg gttggaatcc cgcgctgtca tgtgattgct 2251501 cagcacgcag cggccggaat atgcaataca cattgcgcca tgaatgaagg attcgatttc 2251561 gatatctacc ttttctttca tttctctgat ttcaagagcg ctagtttcac gtgccagcac 2251621 gacgcggtcg agaccttctt ccttccagaa ctggacagcc ttccagtttg aaagagactg 2251681 ctgtgtgctc aagtgaacct caacattcgg cgccactctg cggcatgttt caataataag 2251741 cggatctgcc acaataatac cggcaacgtt ggcgtctcca agcgctttta aatagtcttc 2251801 aagcccgtcc atgttttcat tatgagcgaa aatattcgtt gttacgtaga tcttcgcgcc 2251861 atatttcttt gcgaattcaa cgccttctgc aatttcttcg atcgtaaagt tatcggcatt 2251921 cgagcgaagc ccgtattcct gtcccccgat aaagaccgcg tccgctccgt aatgaacagc 2251981 gattttcagc ttttcaagat tacccgcagg tgcgagaagc tccggctttt tcgtaatcac 2252041 acgctttcca ttaacgattg tggatatttt atcatttacg gcagtcatag cttaacctcc 2252101 ttttgattaa taaaccgttt ccttgaagaa gaatccggta tcaatttttc tgtttactgg 2252161 ctggatgctt tcaatgcgtt cgatccagtc ttcttttttc gcttcgtatt cgtcacggtt 2252221 ttccacgcac aaatcaattg cttctctgta cattttggtg acttctatta ggtattcagg 2252281 cattttcaaa acaccatcga ttttgaaaga atcaattccg gcatctatca attcctcgag 2252341 ctcatcaatg atgcacacat cgttcgggct catgatgtga gtgccgtttt catcttcgaa 2252401 aatcggatat ttattatcgc gttctttatc gtgtaaaaac atgcctgatt cttttttctt 2252461 tctttcaatg tccatgactt tgccctgata ttcaaaatag tttccaatca aagaacgctt 2252521 cgattggaac atgcacgtca ttccatgcac ctggatttca atttcgactt cagcattttc 2252581 tttaatctca acaatgctgt ccatgtttaa ttctctggca agcacagaac gcgccgcacc 2252641 cttgcgtccc cagtagttgc atgtataata gttggtgcct gtcgtttctg tgctccaatg 2252701 aagcttcaga tcaggcgcag attcacgggc agccatcagc acggcaggat cgccgaatac 2252761 cgctgcatcg acaccggctt ctgctaagaa agccagatat tcgccaagct cacccacttt 2252821 atcattatgg aaaattgcat ttacagcaac gtatactttt gccccttctt tgtgagcaat 2252881 ctctacggct tttgttacat cttcacgaga aaattctccg gctaatctca agccgtatct 2252941 ctgttcccca actaaaaacg cagttgcccc agcctgtatg agcggcaaaa tgtccgctgt 2253001 actcgtcggc gtcactaaga gctctggttt tttcatgacg ttcacctctt ctttttacta 2253061 atcgcaagtc cgtccccgac aggaataatc gcagtttgat aatccggatg attcatcagc 2253121 caatgattat attcatcaat tttggctaca agcctgcgcc ttctcttcgg ttctattttg 2253181 ctgtaatcct ctgccaccag acctttaaac agcacgttgt ctgttataat caccccgtcc 2253241 ggtgaaagca tcggttcata taaatgaaaa aagttttgat actgaccttt tgcagcgtca 2253301 ataaaaatga catcgtaagg cgcggttaca tgaacggcgt cggctaattc aagcgcatct 2253361 ccgtaaaaaa catgaatccg gtcatcaagc tgaaattcct tgatattgtt taccgcttct 2253421 tcatgccgtt tctcattgcg ttcaattgta tatatttcag cagacggcag ttccagagcc 2253481 attcgaatgg ctgaataacc aatggccgtt ccgatttcta gtattttttt cggctgtttc 2253541 acagacaaaa tttgaagcag cacctccatg cccgcttttt ccataatcgg gacatgatgt 2253601 tcttctgcat atgcttcaag tctcttcacg ttatccggcc gaggctttaa taatgcttct 2253661 atatagtcat ttatttgttc ataccggtca gtcactacaa acagcctccc gttctaaaaa 2253721 ggagtgcccc agtcttatgc gcaggacact ctctgaatac atcatgatac atcggtaaac 2253781 aacccgatat attttatcat aaaaccttgc ggaaagcgaa caaaaggaga gctttttgct 2253841 ctccttttat ttctcatttt ttgaggaaat gtatttttct tttgctttat tatgctcttt 2253901 tagcgttttt gtaaatacga cctcaccatt tgatttggcc aagaaataca gatagtccgt 2253961 tttatccgga tgcagcgctg cttcccatga tgacatgccg gcattggcaa tcggccctgg 2254021 cgtcagccct gtgtttttat acgtattgta tggtgaatcg atttccagat ccttataaag 2254081 aacccgatct ttatgcttgc ctgccgcgta caggacggtc ggatctgttt ggagcggcat 2254141 tttctttttc aggcggttat aaaagacgct cgcaatttta tggcggtcgg ctttttcagt 2254201 cgcttcttct tctatcaaag aagccattgt cagcagctta tgcacagaaa ctttgttttt 2254261 cttcatttct gatttatatg tttccacata agaatttgtc tgcttaatca ttgccttgat 2254321 aatgtcttca agtgatgtgt ccggatcgtt aaaagggtat gtagccggga ataggtaccc 2254381 ttcaagcggg tgcttaatgt ttttattgaa aacatcattt gtcacagtgt ccgggaattc 2254441 tttcttcagc tgattgataa atgtttcatc gtccagcttc gctatgactt gttttttaga 2254501 gtattttgtt tcatcagcaa tagcagccgc gatttgggtc agctgtgctc cctcagtcac 2254561 tgtgatttga aaagcgtaac ctgtagcccc gcttgtcagc ttctgaataa tggcatctaa 2254621 atccatacct ttattcagat ggtagaatcc ggcctgaaac ccggaagcac ctttatattt 2254681 cacatagtac tgaaacgcct tctcgctttt tatgacatca tttttcttta atatcgatgc 2254741 gatggctgaa acagacgaac cgctcggaat gttaatatta actgtcgttt tactgtcttt 2254801 ttcaacaggt tcaagcaatg atttcccata taaaaatgcc ccgccaatga tgagaaacag 2254861 cacaacaatg gaagacagta tgattctttt tttattaaaa aacgattttt tttgctgatt 2254921 gatatacatt aggtctcctc ccatcagctc ttatactaca tgattcattg tatttcggca 2254981 atttattaca aaaagaggcc tgcataaagc agaaaaaagc cggagcagta tagctccggc 2255041 tttggtttgg cgcgatgttt tactcttcgt cttcgtccgc taagaatgtg tttagtgttt 2255101 cttcgatcat atcccattct tcgtcagttt caatcgggaa tagctcaccg ttttcaccgt 2255161 cttcgtttgg cgtgaagctg gaagcaagaa tttctacttc ttcgtcatct tttgattcga 2255221 ttggatagta caagacataa gatttgccaa actcttcatt ttcaaatgta aacagcactt 2255281 cacaaagctg ttcatttcct tgatcgtcaa caattgtaat atttttttcg ccgtgttcca 2255341 ttttcttcac ctctggcttt aatttaagct gtcaagatat ccttgtaaaa tcataacagc 2255401 cgccatttta tcaatgactt tttttcgttt ttgcctgctg acgtcagctg caatcagcat 2255461 tttttcagcc gccattgtgg taagacgctc gtcccacagc acaacaggaa cattgtacgt 2255521 tgtttcaagc actttcgcaa atgtttggct ggcttcgcct ctcgggccga ctgttccgtt 2255581 catgttctta ggaaagccga gcacgatttt atctatagta tagtccttta tcagttcaga 2255641 taaacgggat aaaccataat cgccttctgc ttcatttatc tttatggtct caatgccttg 2255701 agcagtccag cccatttcat cgctcagagc tacaccgagt gttttggttc ctaaatcgag 2255761 tcctaatatt ctcattcttt atttacgcct ctttatgctg ttctaaataa gactttacca 2255821 attcctcgat taattcgtct ctttcaagtt tgcgaattaa attgcgagcg tcacgatgcc 2255881 taggaatata agcgggatca cctgacagca agtatccgac aatctggttg attggattgt 2255941 agcccttttc ctgaagcgcg tcatacactg taatcagcac ctcatttacg ttagtctcag 2256001 cagaatcatc ggagaaatta aatttcatcg ttttatcaaa cgagctcacc gttttgcacc 2256061 tctttcccaa attcgcaggc aaagttcagc ctggggtcct aatcttacca tcattctaca 2256121 ctacatgggc gaattataaa acggatttca cccaatcttc tacagaagcc aaagcttctt 2256181 ctaatttttc cggctgttta ccgcctgcct gcgccatgtc cggacggcct ccgccgcctc 2256241 cgccgcaaac ttccgcagct tgtttaacca gcttgccggc gtgaagtcct ttctcaatga 2256301 ggtcctttgt gactccggca gagatattaa ctttatcgtt ttgtaccgca ccaagcacga 2256361 tcaccgcaga gccaagcttt gctttgagtt catcgaccat agtgcggaga tgattcatgt 2256421 cttttgcatt tacttttgcc gcaagcacgt ttacgccgtc aacttctttt actttcgaca 2256481 ggattgctcc tgcttccacg ttgcctagtt ttgcaagaag agattcattt tctctttgtg 2256541 catccttcag ttcagcctgc agagccgcga cccgtttcgg cacttctttg atatttgttt 2256601 tcagctcgtc agcggtctgc ttcaatacag aaatctggct gttcatttcg acgtaagcgc 2256661 cttgtcccgt tacagcttca atccgtcttg tgcctgctcc gattccggat tcagaaacga 2256721 ttttaaacaa gccgatttct gctgtatttc tgacgtggca gccgccgcac agctctaagc 2256781 tgtaatctcc aacttgaacg acacggacaa tatcgccata tttttcgccg aacagtgcca 2256841 tcgcacccat ttcttttgct tcagcgatcg gtttcaaatc aatgctgacc gggatgctcg 2256901 cccagatctt ttcgtttacg attctttcaa tttgttcgag ctcttctttt gtcacttggc 2256961 caaagtgcga gaagtcaaaa cgaaggcggt tttccgttac aagagagccc gcctgattga 2257021 catgagttcc aagaacatct tttagagcct gatgcaataa atgcgttgcc gtgtggtttt 2257081 taatgacgcc gcttctcata tggtcttcaa cttcagccgt aacatgcagg cctttttgaa 2257141 cagtaccgct ctccacaaca ccttcatgca catgctggcc gttcggcgct ttttgaacat 2257201 ctttaattct tacaactgcc tgctcgcttc ggagatagcc tttgtcgccg atttggccgc 2257261 cgctttctgc atagaacggt gtttcatcaa gaatgatttg aacgctttct ccttcatgag 2257321 cctcttcgat taattggccg tcctgaagaa gcacaatgat attggcatca gctttggttt 2257381 gagagtagcc gacaaatgtg ctttcaactg tcacgtcgcg cagtgcgccg ccctgcacct 2257441 gcatgctgcc gacatcctgg cgggcgtttc ttgcccgttc acgctgctgg ttcatttcct 2257501 cctcaaagcc ctcatggtca accgtcatgt tctcgtcttc tgcgtattct tcagtcaatt 2257561 caaccgggaa tccatacgta tcatacagtt taaacacatc agcacctgag ataacgctgc 2257621 tgcccttgtc tttttctttt ttgatcattt ctgacaggat cgcaagccct tcattaaggg 2257681 tctcatggaa gcgttcttcc tcggttttaa tgacttttgc gatgaaatcc gctttctctt 2257741 tcacttcagg atagaaatca gccatgattt ctgcgacaac cggcactaaa tcaaacatga 2257801 acggacgatg gatgttgatc gttttggcat aacgcacggc acggcgtaat aagcgtctta 2257861 atacatagcc gcggccttca tttgacggca gcgcaccgtc actgacagca aaggcaaccg 2257921 ttctgatatg gtcagcaatc actttaaacg cagtgtcttt cacattgtct ttgccatatg 2257981 tttcaccaga aatcgattct gttgctttaa tgatcggaac aaacaaatcg gtgtcaaagt 2258041 ttgtcggaac attctggatg acagacacca ttctttcaag acccatgcct gtatcaatat 2258101 ttttctttgg aagcggtgtg tacgtgccgt cagggttatg gttgaactct gagaacacaa 2258161 ggttccatac ttccaggtaa cggtcgtttt ccccgcctgg gtaaagctcc ggatcttctg 2258221 gatcattacc gtatgcttca ccgcggtcgt aaaagatttc cgtattcggt ccgctcggcc 2258281 cttcaccgat atcccagaag ttcccttcca gacggataat tctttcttca ggaataccga 2258341 tttttttcgc ccaaaactca tatgcctctt catcttcagg atgaaccgta acagagagaa 2258401 gctctttgtc gaagccaatc cacttgtcgc tcgttaaaaa ctcccaagcc catgtaatgg 2258461 cttcttcttt gaaataatcg ccgatggaaa agtttccgag catttcaaag aaagtgtgat 2258521 ggcgcgcagt tttacctaca ttttctatat cgtttgttct gatcgctttt tgagcgttta 2258581 cgattcttgg attttccggc acgacacggc cgtcaaaata ttttttcagc gtcgcaacac 2258641 cgctgttgat ccaaagcagt gaaggatcct catgaggcac taatgacgcg cttggctcta 2258701 ccgcatgtcc tttttcttta aagaaatcca aaaacatttg acgcacttcc gcagaagtta 2258761 agtgtttcat tgtatttcct cctctataaa aatcgaaatt ctcttcagtg acagcaaaaa 2258821 agccctcccc ctatgcaaac caacgtttac acagggacga gagctgtctc gcggtaccac 2258881 cctgattacg ggcattcatg cgcccgtcac ctttaaccct gtaacgcagg ataagcggca 2258941 gtgattaact gcactcagga ttagcttcct ccgatcttct gataaagctc ctttcagctt 2259001 atggagcttc tctctttaac agggcttcgg cgtactcaga tccgtcactc gagattcgta 2259061 tgtattctac gagaaattat agacaagcgg cacgccgatg tcaatgctcc gtcctcatcc 2259121 gcaaaaaatg gatcatcatt acttttaaaa cagccgtcgc aggaacagcc agaatcatcc 2259181 cgacgatacc cgcaagctcc cctccggcaa ggagtgcaag catgataacg accggatgca 2259241 ttttaaggct tctgccgaca atgaacggac tgaggatatt tccttccata aactgcagaa 2259301 taaacaccgt aatcaccaca acaagaaccg ccttgactga gatcgtcatc gcaattaaca 2259361 acgcaggaac agctccgatg aaagggccaa aatacgggat gacattcgtt accccagaga 2259421 taaggccaag tatcagcgga tacggaagcc caaataccca gaacgaaatg cctgcaatca 2259481 cgccaagaat caagcagacc aaaagctggc cgcggatata atcgccaagc gaatcatcca 2259541 catcccgcaa aaaggcgctg ccccgctttc tccacgactt cggagtcaag taccatactg 2259601 tctttttcat taactcaatg tccttcacca tataaaacac gagaaaaggg attgttgcag 2259661 caattaagaa gtaatcaagc acattgcgga tcccgctgat cgcaccctcg atcgttcccg 2259721 caaaaaacgc ctccgtctgg cggatcattt tatctatacg gtgatgcata ccatcaggcc 2259781 agtcatccgt atggttatgc acatgaagaa gaagcccgtt atacgtttcg gcaaacatgg 2259841 gtatattttc tgacaaatcc gtcagctgca cgattaaaac aggcacccct ttatacaacg 2259901 cccagccaat cccgccaaaa aaaagaacat aaatgaccaa gatgctcaaa gtcctaggca 2259961 atcctttgcc atgcagccat tctgtgaccg gaagcaataa ataagatata aaaatagaaa 2260021 tgatcaaggg aataaagatc gtttttatga cgagccaaaa gggtgaccat aacatatcaa 2260081 gcataaaaaa gacatagact gttaacagaa ccagcaaaca aatagccacc cacaacaaaa 2260141 gctgcaccgg tttttggagc atctgctttc acctcaccta tatcttttga ggtttacaag 2260201 gaattattct ttatgtttct ttagtcagtc agaagtcatg gacatttttt cacttttaat 2260261 tttcagaaaa gtttgatcat ttactttttg gtcaaatttt ctgataggag gattgcgatg 2260321 atcacatttc aaaatgtaaa caagcattac ggagattttc acgtgttaaa acaaattaat 2260381 cttcaaatcg aaaaaggtga agtcgttgtt atcatcggcc catccggttc cggtaaaagc 2260441 acattgctca gatgcatcaa cagacttgag tcgatcaatg agggagtgct tacagtaaac 2260501 ggcaccgcca ttaacgacag aaaaactgat atcaatcaag tgcggcaaaa tatcgggatg 2260561 gtgtttcagc actttcattt atatccgcat aaaacagtgc tgcagaacat catgctggct 2260621 ccggtaaaag tgcttagaca atcacctgaa caagcaaagg aaacggcgcg gtactatctt 2260681 gaaaaagtcg gcatcccaga caaggctgac gcctatcctt cccagctttc cggcgggcag 2260741 cagcagcgtg ttgccatcgc aagaggactg gcgatgaagc cggaggtcat gctgtttgac 2260801 gagccgacat cagcacttga tcctgaaatg atcggtgagg tgctagatgt catgaaaaca 2260861 ctcgccaaag aaggcatgac aatggttgtc gtgacacacg aaatggggtt tgccaaagaa 2260921 gttgccgacc ggattgtctt cattgacgaa ggaaaaattt tagaagaagc agtgccggct 2260981 gaattttacg cgaacccgaa ggaagaacgg gcccgcttat tcttaagccg tattttaaat 2261041 cattaaaaca gaaatggggg agcttgtatg aaaaagattt tttctttagc attgatttct 2261101 ttattcgctg tcatcttgct tgccgcttgc ggcagcaagg gatcaaacgg agaagcctca 2261161 aaggagagca aaaaagatac gctagccgcc attaaagaca atgacaaaat tgtcttcggc 2261221 gtaaaaacgg acactcgact gttcggtctt aaaaatccaa gctcaggtga gattgagggt 2261281 tttgatattg atattgctaa acaaatcgct aaagacattt taggtgatga gaaaaaagct 2261341 caatttaaag aggtcacctc aaaaacaagg attcctatgc tgcaaaacgg ggatatcgac 2261401 gccattgtcg ccacaatgac gatcactgaa gaacgaaaaa aggaagttga cttttctgat 2261461 gtctatttcg aggccgggca atcgcttctc gtgaaaaaag gcagcaaaat caagagtgtc 2261521 gagaatcttg gcaaaggctc aaaagttctt gcagtaaaag gctccacctc ctctcaaaac 2261581 attcgtgaaa aggcgcctga agcatctgtt ttagaatttg aaaactacgc agaagccttt 2261641 acagccctta aatcggggca aggcgatgcc ctcaccacag ataatgcaat tttatatgga 2261701 atggctgatg aaaataaaaa ttatcaatta acaggaaagc cttttacaga tgagccttac 2261761 gggatcgccg tgaaaaaagg gcaatctgct ctcgcgaaag aaatcaacgc ttcacttaaa 2261821 aagatgaagt cggatggcag atacgatgaa atttataaaa aatggatcaa agaagaccca 2261881 gctgaataac aaccatcccg ggatgagcag gcgatgctca tcccaatttg ataaggagtg 2261941 aataggcaga tgaatgtgtc aattcttttc gataacttca gcatgtatat ggacggtttt 2262001 taccatacct tgctcgcaag tgttatcgcg ctggccggca gttttgtcct cggcgttgct 2262061 gtagcggtta tgagaataac agtctttaag ccgctgcaat ggctcgggac cgcatatgta 2262121 gaattcatcc gcaacatccc tcttctttta attacctttg ttttctattt cggacttcca 2262181 aacgcaggcc tgaggcttga cggttttcaa gcgggaacgg ttgctctcac catttatacc 2262241 tctgcgttta tcgctgaagc catcagagca ggcatccagt ctgtttcaaa agggcagatg 2262301 gaagcggcac gctcgtcagg ctttacctac agccaagcca tgctccatat cattttgccg 2262361 caggcaatca aaatcgtcat tccgccttta ggcaatcaat ttttaaactt agtcaaaaac 2262421 tcttcgattc ttggggttgt ggccggattg gatcttatgt accaagccga tttagtttcg 2262481 tcgagcacac tcgttgtatt tgatgtttat atttttgtgg cgctttttta cttagtgctg 2262541 acgattccgc ttagcatcgg tgttaactat ctggaaaaac ggctggaaaa aagctattga 2262601 taaggagtga gttacattgg atttcatcgg tgcttattca caggagcatt tagcgttttt 2262661 atgggatggc tttctcgtca ccttgtacgt tgctttcatc tccatcattc tgagcttttt 2262721 cttcggttta atcgcaggca ccctgcgtta tgcgaaagtt cccgttcttt ctcaattgat 2262781 tgcagttctc gttgaaacga tcagaaacct ccccttgctg ttaattattt tctttacgtt 2262841 ttttgccctt ccggaaattg ggattaagct tgaaattaca gctgctgcaa ttacagcact 2262901 aacgattttt gaatccgcta tgctatctga aattatccga agcggactga aatcaattga 2262961 caaaggacaa attgaagcgg cgcgctcctc cgggctgagc tatacacaga ccctgttctt 2263021 tatcgttatg ccgcaagcgc ttcgccgcat ggttccgccc atcgtaagcc agtttatttc 2263081 tttattaaaa gatacatcgc tcgctgttgt gatcgccctg cctgaactga ttcacaacgc 2263141 gcaaattatt aacggccaaa gcgctgacgg cagttatttt ttcccgatct ttttacttgc 2263201 ggcccttatg tatttcgcag tcaactacag cctttcactc gcagcaagac gcctcgaggt 2263261 ccggcaaaca tagaaaagga tactctttgg agagtatcct ttttgcatta aaacattttc 2263321 gtaattcttc ttctcatccg cttcatgctt cgattattca gcatgtcaga ttgagtcgcc 2263381 attcggtaca cgagagctcc ggctcccatt gccaaaagag aagtcatcgt ccgattcatc 2263441 ctgcgcatct cctttcatga ttaaaaattg atgctgcgtt catcctcaga aaacaaatca 2263501 tccaagctgc ttaacgttcc gtcttcttcc acctgatgag ttgcaatctt ccctttcgcc 2263561 actgtcagtt caataaaaca gccccagcaa taatattggt tcacgccgat tttgccgata 2263621 tccttacttt tgcaattcgg gcatataagc atacctcaca cctctatccg ttcagaacga 2263681 tctcgtcttt ccgcacctcg acaagcgaat ccgctctttg gatctggcgc ttgcttcccg 2263741 ccaggtcaga aaagaaaccg tccgagagtt catatgctac gattatgccc ctgtccaaac 2263801 aaaagtatac atcttccagc atccccaata tatccccctc ttgcgatttc acaagcttca 2263861 tcttcatctg ctcgtatgtg aagcatgatt tcggaagagg caaaagctgt tctgaactga 2263921 ccgaagccaa tatgcggtca tcaaaaatgg aagagatatc acacgcccgt aatagcgcat 2263981 gatgatgatg caaaaagcgt ttttgtgcaa gaataaaccc aagacaatct cctttcagag 2264041 aaaaacaaat atcggaaatt gtcccgagat aactagaagt tcgttctgag tatactggga 2264101 atccttctac ttcatggcat gttctcaaag tgtgatcaac caccttttgt tgaacaggct 2264161 taggttttgc tttgcgcctt agactcatac gatgaaatca attccactgc aaatgaaaaa 2264221 aaactcccgc ttgcacggga gcattttatt gctgttcttc tttcataaaa tcgaatggtg 2264281 taatgccttc catgccaatg ttggcgtcgt gtacgctgaa cgggagctct ttttgcaaag 2264341 cttcaagctc ggcatccatt tcctcaacct gtacggacag cctgtttttc aaggaggtct 2264401 gtctgacagt tgcatcatta tttttcacgc cccactccag cgcctcctct tccccgcata 2264461 aaatgagaaa tttcttcgct cttgtaatcg cggtataaag aaggtttctt ctgagcattc 2264521 tataatagcc tttcacaaca ggcaaaacca caatcggaaa ttcacttccc tgcgatttat 2264581 gaatagaaca gcaatacgca tgggtaaatt gattaaaatc ttttttcgta aatgtcattt 2264641 cattgccgtc aaaagaaacg acggccatgt cttctttttc tgtattttcc tttgcataaa 2264701 atatcgacgt gatttcgcca atatctccgt tgaacacatt gttttccggc tgattgacaa 2264761 gctgcaaaat tttatctccg gttctgtaga caacatcccc gaacttcaat tctctccgtt 2264821 tttctttagg aggatttaaa atgtcctgca gcatcacatt caattcatta atgccggctt 2264881 ttcctctgta catcggagcg aggacctgaa tgtcctttgc tgtatagcct tttttcaatg 2264941 cattggcgac aaccttctca actacttctt tgatttgcga cccgccgcag cgaataaagg 2265001 aacggtcctt tgtcggggca gtcaaattgt tcggcagcaa tccatttttc atctggtggg 2265061 caagctcgac gattgatgac ccttctgcct ggcgatagat gtctgtcagt ctcacagtcg 2265121 gaatcacctg ggatgccagc aggtctctga gcacttgtcc cggaccgacg gaaggcagct 2265181 ggtcttcgtc tccgacaatg atgatttgta tatgatcagg gatcgccttg aacaaatgat 2265241 tcgccagcca tatatcaagc atactggctt catcgataat taacagcttc ccttcgatcg 2265301 gctgatcctc tgtatgagta aagccttcag cgccgttcca gccaagcagc ctgtgtatcg 2265361 taactgcagg gagtcccgtt gattcactca tccgttttgc tgctctccct gtcggagcgg 2265421 ccaaaacaat cggaaaagct tcatcctttt tataagctga cgggtctagt gacacaccgt 2265481 gaagctctcc gtagagctcg acaatccctc tgattaccgt cgtttttcct gttcccgggc 2265541 cgcctgttaa aagaagcatc ggcgaggaaa gggctttttg aatcgcttcc ttctggctgg 2265601 gggcatactg aacgtccatc cgttcttcca gttctcccaa cgcgagcaaa aactctgatt 2265661 cgggaaactg gttctcatat tcggtttggc tagcgatatg tttcacacgc tttgcaacgt 2265721 tttgttctgc gtaaaacagc gaaggaaaat aacagcggcc atcttctatg acaatgtctt 2265781 tattttctcc aagggcaata attgcgttag cggcatccat ttctgtaatg cgctgccctt 2265841 cccttgctga ctggtttaac agtgattgag tgtcgatgat cagctgttcc gtttctatgt 2265901 acgtgtgccc ctctgacaga caagtcgttt caagcgtgta caaaatagca gcttttaccc 2265961 gctcaggatg attacccgaa agacccattc tgctgcccag ctcatccgct tttccaaacc 2266021 cgatgccttc tacatccttc acaagctgat aaggattttc ctgaatcttt tcaagcgtct 2266081 cggattcata ggcttgatag attttcatag acagctgcgg gccaaagcca aactgattca 2266141 aggaaatcat gatttgctcc agtccctgat gccgctgcaa tgcgccagcc agcgtgtctg 2266201 ctttcttttt tgagagtctg ggaacatcat aaagcactga agcatcagcc aatattttat 2266261 taatggcgct gtcgcccagc tttttcacaa tttcttcagc tgtttttttg ccgatcccct 2266321 cgaataaatc actcgataaa tattgaatga tgccttcctt agtcgttgga atctcctttt 2266381 tgaaatgctc cgcctgaaat tggagcccga attttggatg ggttacgatc tttccgtaaa 2266441 acgtgtaggt ctcttcttct tgaagcgcag ggaagtagcc cgtcacggat acggctttat 2266501 cttcaatggc ttcggaggtc tctgtgactt tcactttcag aaccgtatat aaattggtgt 2266561 cattatgata gatgactgtg ttgactgtcc cttttaaata gggctcttcc tccagtttaa 2266621 gctgatccgg atgctgctgc acgagctgtc cctcctcctg tgcctgttat gatggatcaa 2266681 tcagtttttt agcatgaagc gcaagcatat gatctggctg gatatcgatt gccttgtcca 2266741 gcatttccag cgctttttct cggttttctt tataagcata agtgacaccg gcattataaa 2266801 atgcatctgc atgccccggg tcttgctctg tcacagctgc gaattggctg agcgcttcgt 2266861 ccagcatgcc ctcgttggct aagcacatcc cgaattgaaa acgcgcttcc gtatcgtttt 2266921 cattcagttc gactgctctt tgtaaatatg gcagtgcaag cttaggctgt tcgagcttga 2266981 caagtaccgt tccgagcatg taaaacaggt cgccgttttc catccccgca cgtagcgctt 2267041 tttcaaacat gtctttcgct tctttgtaca tttcttttac aacatagaca tttcctgctc 2267101 cataataagc agtggctgcg ctactgtcta attcaagcgc tttatcataa aacgcaagcg 2267161 cacgttccag ctcgtttacg gatgaaagaa ggttggcaaa attgatatac ggaatcgcgt 2267221 cttctttatt ttcttcaatc gcttttgtaa atgcctctgc cgctttctcg taatcgcctt 2267281 cctgcatcgc ctctataccg agttgattat aatccaccga tcatcttcct ttcattaaaa 2267341 aaccccaact cagtgttgag gtttttcatc ttttatacgt accacaattt tgttccgtct 2267401 ttgtacacat catcaattgt cccgccgcca aggcattctt cgccgtcata gaagacaacg 2267461 gcttgtcccg gcgttacagc gcggacttgt tcatcaaaga tgacttccgc ttcaccttcg 2267521 ccagtcatgc gcactgttac tttatgatcc tcttggcggt aacggaattt agccgtgcag 2267581 gaaatctctt cgcccttcat gatatccgaa cgtacccagc tgatatttgt tgctgtgatt 2267641 ttgtcggaat ataaaagcgg gttatggaac ccttgatcta cgtagaggat gttcttttca 2267701 agatctttgc ctaccgcaaa ccacggctcg ccgcttccgc cgatgccaag gccgtgacgc 2267761 tgtccgatcg tatagtacat caacccgtcg tggcggcctt ttacttcgcc gtccatcgtc 2267821 atcatatcgc ccggctgtgc agggagatat tggctgagaa acgttttgaa gttgcgttcg 2267881 ccgataaagc agatgcctgt actgtctttt ttcgtcgctg ttgcaagttc tgcttctttg 2267941 gcaatttcac gcacacggct tttttgaagt tcgccgatcg ggaacatgac tttgctcagc 2268001 gtatcttctg tcagctgatt caggaagtac gtttgatcct tgttttcatc aatgccgcgc 2268061 agcattctga cttttccgcc gcttctgtct actcttgcat agtggccagt cgctaaatag 2268121 tcggcgccaa gtgacaatgc atgctccaaa aaggccttga atttaatttc tttgttgcac 2268181 aatacatccg ggtttggtgt tctgcctgct ttatattcat caaggaagta ttgaaatacc 2268241 ttctcataat attgcttttc aaagtttacg gcataatacg gaattccgat ttggttgcag 2268301 acgcggatca catcttcata atcctctgtc gccgtgcaaa aaccgttttc gtccgtatca 2268361 tcccagtttt tcataaagat tccgattaca tcatagccct gttcttttaa cagcagggcc 2268421 gccacagatg agtctactcc gccggacatg ccgacgacga ctcttgtatc ctccggccgt 2268481 ttttccattt cattcactcc aattactacg ccgccttatt atgtcagccg tttgacaacg 2268541 tcggccacat gtttggcagc agttttcact tgctcagccg tattgccgag gccgaagctg 2268601 attcgaatag aggacgtcag ccggtcactc tcttcgccga acatagcagt cagaacatgt 2268661 gacggcagga ctgaaccggc cgtgcacgct gaaccgctgg agacagcgac accagccata 2268721 tcaagattaa ccagcagcgc ttccactgac acaccgggga aataaagatt cagaacatgc 2268781 ggcagactat gctctttgtc cccgttgacc tcgaatgcca cacctgcatc tctaagcgtg 2268841 tcggcaaaga ttgctttaaa cgattgatac ttctcgtttt tttcgtcacg ttcttcactt 2268901 gacagcttga tcgcttcttt cagcccgaca atgcctggaa cattttccgt tccggcacgg 2268961 cgttttcttt cttgctctcc tccgaataaa aggggtgaaa gcttcacatc tttactagca 2269021 tataaaaagc ctgtcccttt tggcccgttg agcttgtgcc cggaaacaga cagaaggtca 2269081 atatggctgt ttttcacatc aattggcagc aacccgaatg cctgaacagc atcggtatga 2269141 aaataagctt tgtgttcctt taacagctca ccgatttctt cgatcggctg cactgttccg 2269201 acttcattat ttccatacat cactgtcaca aggattgtat catcacgcag tgcttctttc 2269261 acctgttttg cactgactct tccattttgg tcaacgtcca gatacgttat gtcaaatccg 2269321 tctccctcaa gtttttcaca tgtgtgaagc acggcgtgat gctcaatttt tgttgtgatg 2269381 atatgtctgc caagatcttt tcttgcaagt gcggttccca tgatcgccaa gttatcagct 2269441 tccgttcccc cgcttgtaaa aatgatctcc tgctctgccg ctccgatttc tgctgcgatc 2269501 tgcgctcttg cttcatccac ccattttcga gattctctgc caaatgaatg aatactggag 2269561 ggattaccga aactgccgga gaagtgcggt atcatttgtt ccagcacgcg ctcatccatc 2269621 ggagacgttg cggcatgatc taaataaatc cgttccatta tgtttacacc tctgatctaa 2269681 atatagaaca tataagcttc ttgctctccg tctgtatagc tggcaagatc ctctaatgtt 2269741 gtactgtcta aaacctcttt tacagcatcc cggatgcgaa tccagagctc acgcttggca 2269801 ggctcctcat cttccagcac ttcaacaggg ctgatcggcc cctcaagcac acggataata 2269861 tctcccgcag taatggcatc cggctcactg cctaatacat atccgccata tgcgcctctg 2269921 atgcttttca ctaaaccggc atttctgagc ggcgatacca gctgctccaa ataatgctcg 2269981 gacaaattat tcgtctgtgc gatgcttttt aatgaagtcg ggccttcacc gtgctttttt 2270041 gcaagctcga tcataatggt gagcccgtat cttcccttag ttgatatttt caacatgaac 2270101 acctctgtta tttcatgatt ttccacattt ataatggtaa tttctatatg tttcgtccgt 2270161 ttattatctt atagaccaac tgttattata acataccttc agcgaatttt cattgaggca 2270221 gaaggaaagg ggcctttacc cttttctaat gtacggtttt ccgttaccct gtaattaagt 2270281 aaggagagat gatagatgaa gccattggca tatcggatgc gtccgacaaa aatagaggat 2270341 attatcggcc agcagcatct ggtggctgaa gataaaatta ttggcagaat ggtccaggca 2270401 aaacatttgt catccatgat tttgtacggg ccgcccggaa ttggaaaaac atcaatcgca 2270461 acagcaatcg ccggttcaac aagtattgct tttcgaaagc tgaatgctgt cattaacaat 2270521 aaaaaagata tggaaatcgt agctcaggaa gccaagatgt ccggccaagt gattttgatt 2270581 ctggatgaag tccacaggct ggataaagga aaacaggatt ttctattacc ctatttagaa 2270641 aacggaatga tcattttgat cggagcaacg acggctaacc cgtatcatgc cattaatccg 2270701 gcgatcagaa gccggaccca gatttttgag cttgaaccgt taacacctga actgattaaa 2270761 caggcactgg aacgtgcgct ccatgatgag catcggggcc ttggcaccta ttctgtatcc 2270821 attgatgatc aggcgatgga gcattttgcc cacggatgcg gaggagatgt ccgctccgct 2270881 ttaaatgcgc ttgagcttgc cgtgttgtca acgaaggagt cagcagacgg tgaaattcac 2270941 attacattag aaaccgcgga agaatgcttg cagaaaaaaa gcttttctca cgataaagat 2271001 ggtgacgcgc attatgatgt actgtccgct tttcaaaaat caatccgcgg ctctgatgcc 2271061 aacgctgctc ttcactattt ggctagatta attgaagccg gtgatctgga gagcatcgca 2271121 agacgattgc ttgttatcgc ctatgaggat atcggtttag caagcccgca agccggccct 2271181 agagtgctga acgctattca gaccgctgag cgagtcgggt ttcctgaagc gcgaatcccg 2271241 ctggccaacg cagttattga gctttgcctc tcaccgaaat caaactctgc cattctggca 2271301 atcgatgagg ccctggcaga tatcagagcc ggaaaaattg gggatgtccc gaagcattta 2271361 aaagacgcgc attataaagg agctcaggaa ttaggaagag gaatcgacta taaatacccg 2271421 cacaattacg acaacggttg ggtcgaacaa caatacctcc ctgatcctct gaaaaataag 2271481 caatactata agccgaaaca gactggaaag ttcgaatctg ccttaaagca ggtgtacgat 2271541 aaattaatga aaagaaaata aaacaaaaaa acagccttga tcatcaaggc tgtttttatg 2271601 cattatttat ccttcacacg tttgatttca atgtctttca aaagatccat gacaacatgt 2271661 ccgcccataa tcaaacctgc aactgacggc acaaaagcat tagaggaagg cggcattttt 2271721 gctttacgta ttttcgcttc gtcattcccc acttcttttc tgacatcttc ccgaataaca 2271781 atcgggcttt catcagagaa aatcacttga acgccttttt tgataccctc cttgcgtaat 2271841 ttcgtacgaa cgaccttcgc aattggatca gtgtgcgttt ttgagatatc agcgatttgg 2271901 aagcgtgtcg gatccgtttt atttgcagca cccatgctgg agatgagcgg aatatcccgt 2271961 tttagacatt ctttcattaa atgaatttta taacaaatgg tgtctgacgc atcaatgaca 2272021 tagtcaagac catagtcaaa aaactgctca tacgtttcct ccgtatagaa catttttaac 2272081 gcgatcactt cacactccgg gttaatgtct gcgatccgcg ccttcattaa atcaactttc 2272141 ggctgtccga cagttgaaag cagcgcgtga agctgacgat ttacatttgt aatgtcgaca 2272201 tcatctttgt cgacaagcag aatgcggccg acgcctgacc gcgcgagagc ttccgccgcg 2272261 aacgacccga ctcccccgac tccaagcaca gcaactgtgc tgtttttcag cgtttcaagg 2272321 ccttcttttc cgatagctaa ttcattgcgt gaaaactggt gtaacaagaa cctcactcca 2272381 cattcgtatt ctggtttcat ctataaaatg gctgatccat gagcagccgt tttttctgcg 2272441 cacaaaaaat aaagtcccaa tagtgccgtt gcagctttcc tttgttttga acccgctctc 2272501 agcaggtggg tgccctcttt taaatcttgt aagtcctctt taccgaatga aaagaggcat 2272561 gtacgccatt taaaaatgcg ggctcccaaa tcaaaaaaat gttcggtcaa aactaggtgt 2272621 acaactaaca catcaggact ttatttaact tgtcaaaatc atatcacaga cgattttgat 2272681 tttcaagaat cgaactgcaa attcagttct taactttttt cttgatagaa agatgaagct 2272741 cgtcaagctg ggcgtcgctt acttcgcctg gcgcttctgt catcaggcag cttgcacttg 2272801 ccgttttcgg gaatgcaatc gtatctctca ggttcgtacg tccagcgaga agcataacga 2272861 gacggtctaa gccgagtgcg attccgccgt gcggaggagc gccgtattca aatgcttcca 2272921 gcaggaatcc gaactgttca gccgcttctt ctggtgagaa gccgagaagc gcaaacattt 2272981 tttcctgaat atccttttcg aaaatacgga ttgaaccgcc gccaagctca tagccgttta 2273041 agacgaggtc ataagcttgc gctttcatgt cttcaggcgc tgtttcaatc agctcaaggt 2273101 cttctcggac aggcattgtg aacggatggt gcgctgcgta aaaacggcct tcttccggat 2273161 catgctctaa tagcggccag tcgatgaccc ataagaaatt gaacaatttt tcgtcaatca 2273221 gtccgcgttc tttcccaagc tttaagcgca gggcgccgag tgatgcggcc acaacttcga 2273281 attgatccgc tccgaacagc agcaaatcac cttcagcagc atcaagtgct tcaatcagct 2273341 tagactgctt ttcttcatca aagaatttag cgatcgggcc tttcactccg tctgcctcaa 2273401 ccttcaccca ggcaagccct tttgccccgt agtttgcagc aaaagcgcca agagcgtcga 2273461 tgtcttttct ggagtaatcg ccggcaccgc cttttacatt gatggctttg accacgccgc 2273521 cgtttgctac agctgatgag aacactttaa attccgtatc ctttacaatg tcagacacat 2273581 ccgtcaaaag catgtcaaaa cgcgtatccg gtttatcaga cccgtacttg ttcattgctt 2273641 cgtcatacgt cattcgagga agaggaagct gaagttcctc accttttgtt tcacgcataa 2273701 cctttgccat catctcctca gccaatgaca taatgtcttc ctggctcata aaggacattt 2273761 caatatcaat ttgcgtaaac tcaggctgac ggtccgcacg caagtcttca tcgcggaaac 2273821 agcgggcaat ttgataatat cgttcaatgc ctgataccat cagaagctgt ttaaatagct 2273881 gcggagactg cggcagcgcg tagaactcac cttcgtgcac acggctcggc accaagtagt 2273941 cacgtgcgcc ttcaggcgtg cttcctgtta aaatcggcgt ttcaatatca agaaacccat 2274001 tttcatctaa aaagctgcga acagctttcg tcacgttatg gcgcagctgc atcgtctgga 2274061 acatagccgg tctgcgcaaa tctaagtaac ggtgttttaa acgaacgtcc tctgacactt 2274121 cttcagcttg atcagaaatc gcaaatggag gtgtctttgc agcatttaat acgttcactc 2274181 catcagcatg tatttcgatc gcgcctgttt tcaaattcgg attaactgtt ccctcttcac 2274241 gcgccaccac ttttccttga atatcaagca cgtattcatt tctgatgcct tccgcaatag 2274301 caagcgcttc ttttgacaca tcagggttaa aaacgacttg aacaatgccc gtacggtcac 2274361 gcaagtcaat aaaaatcaat ccgccgaggt ctcgtctttt ttggacccag cctttcagcg 2274421 ttacagattc gccaattgct ttttcagtta tatcaccgca ataatatgtt cttccaaaca 2274481 atgcgtttca ctccttatcc cttttggttt gccttcatca catgtataaa ttcatcaagt 2274541 gccacttcaa tctgttcgcc cgtctgtgca tcctttacat tgattttgtt ttgggcaagc 2274601 tcatcttcac ccaaaatcgc aataaatctg gcctttaagc gatcagctgt tttaaactgg 2274661 cctttcattt tcttattttc ataatcgatt tcactggaaa tgcctgcttc tctcagtttg 2274721 tacaccaatg aaacagaata atcctttgct ttttcgccga gtgtgacgat atagcagtcg 2274781 attcccttat caacaggcag ctctcttttt tcagcatcaa ttgcggcaag caagcgttcg 2274841 atgctcatcg caaatccgat gcccggtgct tcaggtccgc cgatctgttc gacaagcccg 2274901 tcgtagcgtc cgccgccggc aagtgtcgta atcgcgccaa agccctccgc attgctcata 2274961 atttcaaatg cggtgtggtt gtaataatcc agccctctca caaggttcgg atcgatttca 2275021 tacgaaatgc caagatcatt taagtattgt ttcacttttt caaaataagc ggctgattct 2275081 tcatttaaat atgtcaaaat cgaaggtgcc gatttcatca gctcatgatc acggtctttt 2275141 ttgcagtcca aaattctaag cgggttcgtg tgcagccggg actggcagtc tgaacaaaat 2275201 tcttcgatgc gaggctcgaa gtgtttcacg agcgcttctc tgtagctttt gcggctatct 2275261 tgatcgccga gactgtttat gacaagctta acgttttcta aacctgcttt ttcataaata 2275321 ctcatcgcaa gcgccattac ttcagcgtcg attgcagggt ctttcgaacc aatcgcttca 2275381 attccaaact gataaaactg gcggtaacgg cccgtctgag gacgttcata acggaacatc 2275441 ggcccgacat aataaagctt tgtcggctgt acaggatttg cgaacagctt gttttcatta 2275501 aaagcgcgaa ccgcagcagc tgttccctcc ggacgaagcg tcaggcttct gcctttgcgg 2275561 tcctcgaagg tatacatttc tttttgtacg atatccgttg attctccgac gcctctggca 2275621 aacagttctg tatgctcaaa aatcggtgtg cggatttctt tatattgata agtgcggcaa 2275681 gtgtctctca taatttgttc aacaaactgc cagcgatctg attctccagg cagaatatcc 2275741 tgtgttcctc tcggaatgtt atatcccata ggtagacctc cttatgtatt ccttataaaa 2275801 tatccaatga tcgttaatga tgaaaatgaa aaaaactccc gcccctacta tacatgatag 2275861 tagggacgag agttataccc gtggtgccac cctagttgga atacgttcat attcccgctc 2275921 gatcctttaa cgcaggttca cgttcactgc ctaatggcgt tattcacgcg ttcagcagga 2275981 aacctccgga gtgttgtttc gagaaagacg caatgggatc cgctttcagc ctggggcggg 2276041 ttcctctcta atcatgcaat ctgacctact cttctccatt attggttcaa atctttcatc 2276101 atttgctatg tactcaattt ctattataat aatgggattg gggttctctg tcaagcttta 2276161 ttccggttgt ttttcctcag cgctgcttct ttggacataa gaccaaattc agatgctgtt 2276221 tccgtaagat aaccagtcgt atcgggatct gcgtgatcgc tgtaatgcag attcgcttca 2276281 ccgtcgtgaa atgcacgtcc catttttgga tgatatttca tgatttgcac acctttttga 2276341 ttgtatttac gcttagtata aacaaatcat tttattttta tttaaaaatc agaaaggact 2276401 ttacgatatt aaacaagaat gcttttttaa tgatcatcag aaaggaggac acaatgaaca 2276461 agaaatactt tgtccttatt gtatgtatta ttttcacctc agcgctattc ccgacctttt 2276521 catccgttac agctgctcaa ggagaagcgg tcatcgcaac agatgaaatg aacgtcagaa 2276581 gcggcccagg gcttagctac ggcattacag cggaagtaaa aaagggagaa cgctatccaa 2276641 ttttaaagga agatggagac tgggtgcaga tacagcttgg ttctggagaa aagggctggg 2276701 tagtctcctg gcttattaca aaggaagacc aggccagcac aagctcctca ggaagcagtg 2276761 acactgtgac atcaacagac cccgatctgc ggatgagaag cggcccgggc acttcctacg 2276821 aagtcatcgg caaattcccg caaggcagcc aagcatctgt cattgataaa gattcgggct 2276881 ggatcaagat atcctatcac agtgccaccg gatgggtatc atctgaatat gtcacatcag 2276941 gaggcagcag ttcagcgtct gatgagagtg accaaaccga ggattccggt gcgtcaacga 2277001 cgggcacagt cggtgtttct tcgctaaatg taagagcctc cgcctcacat gacgcggcaa 2277061 ttataacaaa acttgatcgc ggaacgaaac tgacggttct caacgagaaa aatggctggg 2277121 ctcacattga ggtgaacggg ctaaaaggct gggttgcaag ccattacctt ttgactagtt 2277181 ctgttccagc tgatgattca gcaaatgccg gcagttcatc ctccgctaaa aaagcctata 2277241 tcatgtacgg aggaacgaat ctaagaagtg atgcgtcaac atcagcttcg atcgttgagc 2277301 gcgctgccaa aggagattca tacaccatta ccggttcaaa gggaagctgg tatgaaataa 2277361 agcttgataa cgggcagact gcttatgtag ccaattgggt ggtccaaacg tctaaaagcg 2277421 cagaagaagc aggtgaaccg ccagtctctg attccccgtc tggaaacggc tctctaaaca 2277481 ataaaacgat tattgttgac ccgggacatg gaggaaaaga cagcggaacg atcgggtatt 2277541 cggggaaatt cgagaaaaac ctgacgatca aaacggcaaa actgctcgcc agcaaactta 2277601 gatcggctgg agcggatgta tatgtgacac gccaggatga tacctttgtc agcctgcagt 2277661 cacgggtctc tacctctcac taccgtaacg ctgacgcctt tatcagcatt cattatgaca 2277721 gctatgcgga tacctctaca agaggcagta cagcatatta ctacagtcct gccaaagatc 2277781 aggaactcgc atcagatgtc cactcagaag tggtgaagcg ttcttccatt ccagaccgcg 2277841 gcgtattatt cggagattat tatgtgctcc gggaaaacag acagcccgct atgctgtacg 2277901 agctgggata tgtaagccat ccgcaggaag aagccattgt acatagcaat tcataccaag 2277961 aaaaagtaac agatgggatc gaaagcggat tagagaaata cttccaataa aaaaagctgc 2278021 cttttggcag ctttttttat tttgaatcca taatgagcgt gaccggtccg gagtttgtaa 2278081 gctgaacatc catcattgct ccaaacgttc cggtctccac tttgattcct ttttcacgaa 2278141 gcaggtcatt ccatttttca taaagaccta aagctttatc aggtttggcc gcgttcatgt 2278201 agttcggccg gcgccctttt ttcgtatctc cataaagcgt aaactgtgag acggataaaa 2278261 tctctcctcc tatatctaca agagacagat tcattttccc ttcactgtca tcgaaaatac 2278321 ggagattgac aactttatcg gctaaataag ctgcatcatc ttctgtatca tcgtgagtga 2278381 tgccgaccag caccataagg ccttgtccaa tttggccgac gacctcttcg tccactgtaa 2278441 cgcttgcttc tgttactcgc tgaacaacta atctcttttc taaccccttt agttcatgac 2278501 gcggcgcaca gaatagatat ctctaatctg tttaatacgc tcgacgactt tatgcaagtg 2278561 attgatattc tggataaaaa tcgccatatg gatggttgcc actttattgc gatccgattt 2278621 gccagagaca gatgaaatat tggttttcgt ttcattcact gcctggagta cctcgttcag 2278681 caatccgcgg cggtcatacc caagaatctc tatctcaaca ttgtattcct tgcgcttttg 2278741 aacttgtgac tcatgttccc actctaccgg gatcagccgc tcttgggctt cattcgtttt 2278801 gacattcgga cagtcttcgc gatggaccga aacccctctg ccttttgtga taaagccgac 2278861 aatatcatca cctggcacag gattgcagca ttttgataaa cggacaagga ggttgtcaat 2278921 gcccttgaca cgaacgccag cttcccgttt tcttccttgc gggtatggct taggttcccc 2278981 agtgacttcc tgaacgatct tttcctgttc ttcctggtcg cgctgctttc tctctttttc 2279041 tgttaggcgg ttcgccacct gcagagctgt gatgccgttg taaccgaccg ccgcgtacat 2279101 atcctcttca tttgagaaat taaatttgtc agcaaccttt tgaatattct ccggcgttaa 2279161 aacatccttc aattcaaaat ccaagttttt aatttctttt tcgaccagct cacggccttt 2279221 ttcgacattt tcttcacgcc gctgtttctt aaagaattga cggattttat gcttcgcttg 2279281 ggatgtttgg gcaagcttca cccaatcctg gctcggaccg taggaatgct tagaggtgag 2279341 aatttcaacg atatcacctg tccgaagctt atggtcaagc gtaaccattt ttccgtttac 2279401 tttggcaccg attgttttat tgccgatttc agagtgaatc cggtaagaaa agtcaatcgg 2279461 aacagaaccg gacggaagct cgattacatc tccttttggc gtaaagacat acaccatgtc 2279521 agagaacaaa tcaattttga gcgattccat aaattcttct gcatctgtcg attcattttg 2279581 aaattctaaa atttcacgga accaagaaag ctttttctca aaggttgcac cttcattggc 2279641 tgctttccct tctttataag cccagtgagc cgcaaccccg tattccgcta tttcatgcat 2279701 ttcaaaggtg cggatctgca cttcaagcgg atcgccttta ggcccaataa ccgttgtatg 2279761 aagcgattga tacatattcg gcttcggcat tgcgatataa tctttgaatc tgcctggcat 2279821 cggtttccag catgtgtgaa tgatgccaag caccgcgtag cagtccttta tgctattcac 2279881 aagaatacgg acagccaaca aatcgtaaat ttcattgaat tgcttatttt gcagcaccat 2279941 ttttcgataa atgctgtaaa tatgtttcgg gcgtcccgag aagtcagcct tgatatttac 2280001 ttcttcgaca cgtttcttca cttcattgac aacctcatcg acataaagct ctcgttctgc 2280061 acgtttcttc ttcatgaggt tgacaattct gtaatattgc tgagggttca aataacggag 2280121 cgccgtatct tccaattccc acttaatttt tgaaatcccg agacgatgcg ccaaaggagc 2280181 aaaaatttcc agcgtttcat tggagattct ccgctgtttt tcctgaggca gatgtttcag 2280241 tgtccgcata ttgtgaagac gatccgccag cttgatcaat atgaccctga tatcttgagc 2280301 catagcgaca aacattttgc gatgattttc cgcctgctgt tcctcttgag atttatattt 2280361 aattttgccg agtttcgtta cgccgtctac aagcattgcc acttcttcgg aaaatgcttc 2280421 tttcaggtca tcgagcgtca catctgtatc ttccacgaca tcgtgcaaaa atccgcccgc 2280481 gattgtggaa gggtccattt caagatcaac gagtatcccc gcaacctgaa tcggatgaat 2280541 aatatatggc tcgcccgatt tgcggtattg ctcgcgatga gcatcttcag cgtacagata 2280601 tgctttttcg acaaatgcga tatgctcatc agatagatag ctgcgtgctt tatctataac 2280661 ttgctcggca gtcaatactt gttcgttcgc catggaatca ccttttttaa aatgtaaact 2280721 gtattgtagt ttattatcaa gaaaaaaacg aaagatgtaa agagcagaag ttcaaatagc 2280781 caaatattat ataaaataaa tgcaaaacaa taggaaaaaa gcaccctgac atggagtgct 2280841 ttttcgttat gcggttatcc ttagtatttc atcaatgtta agatgtcgta atcttcgagc 2280901 ttatttctgc cgtcaaggta agaaagctcg attaagaaag cgataccagc aacaacgccg 2280961 ccaagttctt caacaagttt gattgtcgct tcaattgtgc cgcctgtcgc aagcaggtca 2281021 tctgtaataa gcacacgctg accaggctta atcgcatctt tgtggatcgt taatacgtct 2281081 tttccgtatt ccaagccata atccactttg attacttcac gaggcaactt gccttctttg 2281141 cggaccggcg caaaacctac gccaagcgcg taagcaacgg gacagccgat aataaagccg 2281201 cgcgcttcag ggccaacgac caaatcaatt tgcttttctt tcgcatattc aacaatttga 2281261 tctgtggcat agcggtatac atcgccttta tccatcagtg tcgtaatatc tttaaattgc 2281321 acgccctctt tcgggtaatc cggtacaatt gttacgtatt gttttaaatc catctgtttt 2281381 atgtcctcct cgtactttca taagcctctg aatcttgttt catcagctta ttcagccatt 2281441 ccttcagctc ttcagcagaa gaataattca gcttttgatc cagttccatc agctgctgtt 2281501 tcgcctgata tgtttgtgag tctgttaagt cgcgtttctt tgctccgctc acaacagaca 2281561 gcacaccatt ctctatttta acaaaaccga gatcaaaaaa cacctttgtc atgaaattga 2281621 ttgtttcaac ggaccagcct ttatgttttg caagctctga accgtgtttt ttcacgtcaa 2281681 aagcgcctct tttcagcaag aacgcataat accatttaaa gtggtctctt gcgggaaaag 2281741 ttgataaaaa gtggtcctca tgattgagaa aaataaaata tatccgctcg ggcgcctttc 2281801 cttccagcaa acgtgcgagc atgtccagcg aaggcggcgg atccagtaat acaatatatg 2281861 caccatcgag gtcaaacgcc tttgcttgat ctttagaact gatgacgtgc acttctcggc 2281921 gaaggtcttc agtttgaagt aatgttgttg agtcttcttt gaaagagaca atggcccgtt 2281981 tagcagatgg aagggcggaa actgtgtctt cccacgtccg ttttcccctt aaatcaaaca 2282041 gctgccattc agaaacagcg gcatccttta tcataagctg cggctttttt cgattgttcc 2282101 attcgttgat tgacatctca ccgacaatgg aaattcttga acccggtacg atgccttctt 2282161 gaagctcgcc tttattaaaa ccgacgcaat caagctggga cgactcgttt ctgatcgtca 2282221 ttttgacatg agttttattt gcccctatct tgcggacatc ttccagtact gcattttcta 2282281 cgagaacgtg cggtttcggg ttcagcatgc caaaaggaga cagcatgttc atttctgcga 2282341 tgctttcaac tgtaatgtct tcgacgccgc agacaaggtc gacttcctgt acgggaataa 2282401 aatcctcttc cgtaagcgta ttgtccgcta tttcattcag cctgcttcgc aaatccggca 2282461 catcttcggc tttcagcgtc atccccgcag ccattggatg gccgccgaaa tgaggaagaa 2282521 tatctctgca ttcagaaagg ctctcaaata aattaaatcc tctgatgctt cgggccgaac 2282581 ctttagcgat tcccttttct tcatcaatac caagaacaat ggccggtcgg tagaaacggt 2282641 ccacaagctt tgaagccaca atcccgacga ctcccgggtt ccatccggct ttggccacga 2282701 caattgcagt ttgatcgagc ccttgctgtt caaccatttc aatcgcttca tccgtcattt 2282761 tgctgaccat tttttggcgc tctttgttca gctggtcaat ttctgcggca agctcttccg 2282821 cttcaaacga atcctctgac ataagcaaat gaacagcggg atccgcctgt tcgattcttc 2282881 cgacggcatt cagccttggt gcgagctgaa atccgactgt ttcttcgttc gcttctccga 2282941 tgtctccgcc tgacagctta atcagctctt ttaagccgag ccgatttgtc cgtcgaagcc 2283001 tttcaagtcc tagtgttgct attaatctgt tttcgtcatg cagcgggact agatcggcaa 2283061 tggtgccgat agccgccagg tcaagcagtt catcaggaag ttcacccaat aaagcgtggg 2283121 caagcttaaa cgcgactcca accccggcaa gctctttaaa cgggtaagtg cagccaggct 2283181 gcttcgggtg gacgatcgca cggacatccg gaagctccgg tcccggttca tgatgatcgg 2283241 taatgatgac atccagtccg agttcctttg ccaccttcgc ttcatgcaca gcggcaattc 2283301 ctgtatcaac cgtaatgatc aaagagaagc cccgttcttt aatcgaacga aacgcctgtt 2283361 cattaggtcc atatccttct ttaaaacggt caggtatata aaaatcaact tgagccgaca 2283421 gtttttgcag cgtgtgaagc atcactgacg tacttgtaac cccatcggcg tcataatcgc 2283481 catatatcat aatcttttct tgttgtgaaa tcgcctgttt tattcgatct gccgcttctt 2283541 tcatgccttt catttcaaaa ggatcataaa aatcggcatc ctttgtatgt aaaaacagcc 2283601 tagcgctttc tgccgtatca aagcctcttt ttacaagcag ggacgcaaca agaggtgtta 2283661 tatgcaattg ttctgtgagt gatttgacct tatcctgatc tggtcgctgg atttcccatc 2283721 gcatttttga cgctaacata aattcacccc tcaaccaccc tattatacta gagcaggctg 2283781 aggggtttca aataatattc gaaaactagt cttttttctc aatcatggct gatgcatcct 2283841 gtgtgtcagt ctgatcagca agatgagtat cctcttgttt atgtattgct gttctatttt 2283901 ctttccgcaa ggtttttatt tcccgcttca atttcattac ctgaaaaatg ccgacagaaa 2283961 atacgatcag tgctcccatt aaaactgagc ccaaaataac aagaatgagc ggccattctg 2284021 atcttccaaa caggtaatca acttctacgg atcgaacatt aatgactgcg aaaatagcga 2284081 caattaaggt gaaaataagt gcgaaaataa tggtccattg tttattcatt ctcttttccc 2284141 ccaaacttct tattgaggta actttcccaa tcaagactgg ttttaaacat ggcttaacac 2284201 taggttaagc tccctttgct gttaattttt cccggatcag cctcttcagt ccggttccct 2284261 caccggaaat cacaagtgta tcgccttcgt caatgactgt ttcagagctc ggattcagtt 2284321 gtttatcctg attcttttta acaattgcaa tgaccgtcac atgatattcc tgacccacat 2284381 tcaaatcacc aatcgtctga tgaatggcag gcgctcccgc ctctgcttta caccactcta 2284441 taatcaaatc atcaagggct gactcgacct gttctaatgc tttcggttta tatgccattc 2284501 cgccaagaat tgcagacatt tgccttgctt cagcgtcatc aaactgcacg gaggcaacac 2284561 attcctcatg gtcgttttcg tcaaaatagt aaagctctct ccgtccgtca tgatgaatga 2284621 taattgaaat tttatcacgg tttctagtaa tcatttcaac tttttgtcct atgcccggca 2284681 gctctgattc gcgaaccctc atatataaac cctcctacat atctgaaaac cagccataaa 2284741 cacttttaac accatatata tgtttaaatg taagcgtatg tcattatagc aaatgtctat 2284801 tttaagttca atgaaacttc aaaaaacagg ctgccctgca gaggacagcc tgatattttt 2284861 tattgcgccg aatctttttt cagttctctt cctttccatg caagccaaat ttgtgcggca 2284921 atgtatagag aagaataaac gcctgttaac agcccgacca ataaagcaat tgagaagtta 2284981 gtaatagaag atgctccaaa gatcagcaat gtcacaacaa caatcacaac ggttaataca 2285041 gtgttaattg aacgtgtaaa ggtttgctgc aggctcaggt ttacaatatg gttcagatcg 2285101 gcaaaggttt tcggcttacg ctttttcata tgctcgcgga ccctgtcaaa tgtaacgatt 2285161 gtatcgttaa tggaataccc gattatcgtc aagatggccg cgatgaatgt aacatctacc 2285221 tcaagccttg taatactgaa gaacgtgacg ataaagaatg cgtcatatag caatgaggcg 2285281 atggcagcaa tcgccatttt gtattcgaat cggattgaaa cgtaaataat gatgccaata 2285341 gaagctatag caactgcgta cagcgcattt ctcgccagct ccttaccgac tgtcggtgaa 2285401 actgtgctga catttggatc agatccgtat ttgtctttaa aatacgtttt tacttttgca 2285461 atggtttctt tatctggcac cccgacaaaa cgggcaacac cgatattgct cttttcgcct 2285521 gacagaacta cagtatcagg gtccataccc agagattcaa aatccttctc aacttgctct 2285581 gtcgtcagct tatggtcgct ttgcacttca atccgtgcac cgcttgcaaa gtcaatgcca 2285641 agattcagcc tgaacacaag caggataata atcccggcaa ccgtgaccgc actggagaaa 2285701 ataaagaagt atttgcgttt gctcgtgaaa tcccattttt ggaatggcgt atgcggctct 2285761 gtattttcat ccgtatcctg aatatccatg atatgtttct tattgacacc aaaccagcct 2285821 tttttccgat caagccatct gctttccaca aggagagcga ggagaaatct cgataagaaa 2285881 acggcagtga taaagcttgt caaaatcgat aggatcagca ttgtcgcaaa ccctttaaca 2285941 gagcttgtcc caaagataaa gagcacaacc gctgcaataa tggttgtaat attcgcgtca 2286001 aaaatcgtcg caaatgaccg tctgtttcct gaacggaagg cagagcggac tgactttcct 2286061 agcttgagct cttctttaat ccgctcatag gtaataatgt tggcgtcaac agccatcccg 2286121 acacctaaaa tgagagcggc aattcccgga agcgtgagta cggcattcat ccagtcaaag 2286181 atctggagtg taatgtagat ataaacagac agcgtaatca ccgcgattaa tcccggcaga 2286241 cggtaataga aaagcataaa taagaaaata attgcgatac cgacaatacc ggcaaacacc 2286301 gtatcatgga gagcctgctg gccgaattgc gcgcctactg atgtcgaata cttttcagtc 2286361 agtttcacag gaagtgcgcc tgcgtttaaa atgctggcta aatctttcgc ttcttgagct 2286421 gtgaaatgac cttcaatttt tacatcagtt gtatttagtt cctgacttac atttggagcg 2286481 gatacaaatt taggatgctc tttttgaact tctttcttaa aggaatcacc tttatcataa 2286541 tccaaccaaa tgacaagctg gttgtttggc gccattttca tgaccttctt ggtcacttca 2286601 ccaaatttat cagcgtcttt cagcttaatc gtgacaattg gctcatttgt tgtgctatca 2286661 taagtttgtt tagcgccgtt ttcgactaga tcagcaccgt ttaacagttc cttatcattt 2286721 gcatctctga aagaaagctg cgcttcagtc gccaaaattt cacgcgctct gttttggttt 2286781 gtcacgccag cgagctgaac gcgaatccgg ttattccctt caatttggat gttcggttcg 2286841 ctgacaccga gaacattggc ccggcggttc agtgcctcta ctgtgctgac cagaacgtct 2286901 tttgtgattt tgtcaccttt ttttacaggc tgtacatcat acagcacctc aaatccgcct 2286961 tgcaaatcca atcctaacgt aatattgtta gcggcaggct tcgtaaagta gcccaagccc 2287021 gtgccgatca atagaacgaa aaggaaaaac gcaatcaagc gtcctttttt cattatgtat 2287081 atcctccctt aaacctgtgc gaatcaacct gctatctcag cagttcttcc aatgcttcct 2287141 ggccctcttc actgcccagc caattagacg ttttaaatga ctcaacggtt gcatagttca 2287201 taaattcgcc aattttcact gataaaatat cactcgccag ttcataaatg ctcagttccg 2287261 ttttcttttt ccacttctta tctgttaagt atgaccacaa actttcgagt tcaacatcat 2287321 catacccgag aatcttaaac tcttccagtt tgctgtaaag aaacggcctg acgtggtctt 2287381 tatatagatc ggctggatgc ttctccacga attccacgct ccttttttat tgtttttcaa 2287441 gaagacttgt catgcttgga cgacatatac gcatatcttt attgtatatg attccaggta 2287501 gtttgagaag gcagggggta aaaatggcga aacagacgtt tttaaagggc actcttatcc 2287561 ttatcgcagc aggaatggtt acaagaatgc tcgggtttgt caaccgggtg gttatcgccc 2287621 gttttatcgg tgaagaagga gtcgggcttt acatgatggc agcgcctact ttcttcttgg 2287681 ccactacatt aactcaattc ggtctgccgg tcgcgatcag caagctagtc gctgaagcca 2287741 gtgcgcgcgg agatcatcaa aaaacgaaaa atattttagt catgtctctg accattacgg 2287801 gagtgctcag cctcatcttt acaccgctgt ttctgttttt cgcccctgtt atggctgaaa 2287861 cgatgctgac agataagcga acactgtatc cgctcttggc cattacgcct gttgtgccga 2287921 ttattgctat atcgagtgtg ctgaggggat actttcaagg aaaacagaat atgaacccgc 2287981 ttgctatgtc acaagtcctt gaacaggttg tccgcatttc actcgtggct gtctgcacaa 2288041 cgatttttct cccttacgga attgaatatg ctgcagcggg ggcaatgcta tcctcagtgg 2288101 caggggagct ggcatcactt ctttatttat tcgtttgctt taagtataaa aagacaatta 2288161 aaatcagaaa gcatttttta cagtcaatta aaaacggaaa acaaaccttt acccaattaa 2288221 tgagcgtgtc ccttccaaca accgggagcc gctttatcgg aaacctctct tggtttttcg 2288281 agccaatcgt cgtcgctcaa agccttgcca tcgccggtgt ggcaacagtt gccgcaacaa 2288341 agcaatacgg ggaactaacc ggctttgcca tgacgctgct gactctgccc agctttatta 2288401 catattcttt gtcgaccgcg cttgttcctg cgatcagtga aggaatggag cagaaaaaat 2288461 tgcaggtggt ggaataccgc ttagaacagg cgatgcgtct ctgtctgctc agcggaggca 2288521 tttcagttgt tattttattt gtatttgcgg atgagctgat gagagtgatg tacggttcct 2288581 caggcgcagc tgtatttata aaagtgatgg ccccgttttt tctgctttat tatttccaag 2288641 gcccgcttca agctgtgctg caggcgctta atttggcagg agctgcgatg atgaacagct 2288701 taatcggagc gcttgtcaaa acaggcctta tttttgtcct tgccacaagg ccttctcttg 2288761 gcattatggg cgcggcatta gccattgtga caggcatggt gctcgtcacg ctattgcacg 2288821 cagcaaccgt aagcaaagtg ctgccgatca gcatcaaaat caaggagtac gcgctcagct 2288881 tcgctgttat tgtaatttgc ggattcatca gctccgccat caaacaatat ataagctttg 2288941 gagcatctga ggctgtcaat ctagccggat ggattgcggc gagcgccgcc atttatatga 2289001 tcctcctgct cgttttccgt ttaattaaaa aagatgagct tcgccgcatt cccattatcg 2289061 gacggttgat catccgataa tggtcacgtg cggtgcccat ctttttcatc aatatatatt 2289121 tctccgtctg taaacgagca aaatgaaata tctgaagggt ttgtgtatcc gtgtttttgc 2289181 aaactttcaa gcagccattt tctatcttta ctgattctgg acaggttttc tgtttgaatg 2289241 aagccgtcta taatgagcgg catttcgagc tgccgatgct ctccgctgtt ttctttctta 2289301 acaatagtca gtttgcccga cggctctaaa atagcaaatg atacgtcagc tactctgtcg 2289361 atgctatttt ctctgagctg aaccattaaa tcatcaaaat tataacgctg tgatttcatg 2289421 gcttcttcgt caatttttcc atatttgata attatggtcg gcttaccgtc aagaagctgg 2289481 cggacttttc ggttttttaa agaaaagtat gccaaagtca cttgaatgat cattaataca 2289541 agcattggca aaatggtatg aaatagatga tcgtctacgt tttctatggc taaaacggca 2289601 atttcagcca tcatgataaa gacaacgaga tctaaaatac taagctctcc gatctcccgt 2289661 ttgcccatga aacgaaaaat gaccaatatc acaaaataca atacgactgt gcgaaacgca 2289721 atagtgagaa gctcttccat tatgcacctc caactcatta taggttgcaa caaaatgatc 2289781 aatttatgta agaaaaaccg attgcatttc acaaagcttt tacgtctaat tcatgggata 2289841 agggaataca tttttacaaa gacgagccat cagcatgtct gacggttttg aacaaaaaga 2289901 acagaagcct tttaatacag gcagagagga gacaatcatg gaggaaacga aacaagttgg 2289961 aaaaggcatt ctttacggct taatcgccat attttcagcc atgctcctga caagtttagc 2290021 ggtttcactt ttattgaccg caacctcgct ggaagaatca tcatttaact ggctgatcac 2290081 cgctatctca tttctctctt tatttatcgg cgggttcatt tcaggcggga aaggcaagga 2290141 aagaggctgg atgattggcg cattgaccgc cttaagtttt tctctgatta tcttattgtt 2290201 tcagtattta ggattcggaa agacatttac agcagaacag ctgatcttcc atctgggatt 2290261 tttaggggtg tgcatgctgg gcgggatttt cggcgtgaac atgaggggaa acaggtcttc 2290321 cacataaaaa agagcgggct cacttgcccg ctcttttttg tttgctatgt atagctcctg 2290381 ctgttattca gcagcagaaa cttctctgat cgcgcggcgg tcgaacgtaa gacgtgtgtt 2290441 atcaccagtc ttaattacga ctttgctttc gtcgatagag tcaacagtac cgtgcaatcc 2290501 cccgattgtc actactgaat cgcctttttt cagttcctct tgcatttggc gtacagcctt 2290561 ttgctgcttt tgctgaggac gaatcagcaa gaagtaaagg accgcaaaca ttaaaataat 2290621 aggaaccaat gtacctaaag tgccagtcat cattttcacc cctttctgta agcctgttat 2290681 gtttatttag aagcttttcg catttggctt gttatagccg taacgctcaa agaactcttc 2290741 tctgaaatca cccagacgat cctcgcgaat agcctgtctt acctgctcca ttaagtgtaa 2290801 cagaaaatga aggttatggt aagttgttaa tcgaaggccg aatgtttcat tgcagcgaat 2290861 caagtgccta atgtacgcgc gagtgtagtt tttacatgta tagcaatcac actcttcatc 2290921 aatcggacgg aagtctcttt caaatttcgc atttttcata ttgagtcgtc cttcagcagt 2290981 aaacactgtg ccgtttcttg caatccgtgt aggcagcaca cagtcaaaca tatcgacccc 2291041 gcggatcgct ccgtcgatca gtgcgtccgg agaacctact cccatcagat atctcggttt 2291101 atccttcggc aagagcggtg ttgtgaattc gagtacacgg ttcatgacat ccttcggttc 2291161 acctacagac aatccgccta tagcatatcc cggaaaatca agcgaaatca agtccttcgc 2291221 actttgtgtc cgcagatctt catattctcc gccttgtaca ataccaaaca gcccttgttc 2291281 atcctgacga ttgtgggcat tcaggcagcg ttccgcccag cggcttgtcc gttcaactga 2291341 cctcttcatg tagtcgtact ccgccgggta tggcgggcat tcgtcaaacg ccatcataat 2291401 atcagagccg agtgcgtttt ggatctccat cgctttttcc ggagataaaa acagcttgtc 2291461 tccatttaga tgattgcgga aatggacacc ctcttcctct atattacgaa acttgcttaa 2291521 agaaaagacc tgaaaaccgc ctgaatctgt taaaattgcg cggtcccagt tcataaattt 2291581 atggagcccg cccgcttctt tgacaatgtc ttggcccgga cgaagccata gatgataagt 2291641 gttgctcaaa atgatgcctg catccattgc tttcagctct tcaggcgaca ttgttttgac 2291701 tgtcgccagt gtgccgaccg gcataaaaac cggcgtttcg aaggagccgt gaggcgtatg 2291761 cactttgccc agccgcgctc ctgtttgttt gcattctttt ataaattcat agcgtattgg 2291821 ttgttcagcc acttttgatg aggcctcctg ttctcaaatt atataatcag catcgcgtct 2291881 ccgaagctga agaaacggta ttcctcttcc actgcatggt tataggcacg cagaatgttt 2291941 tctcttccag caagcgcgct gaccagcata atcaatgacg atttcggcaa atggaagttt 2292001 gtaatcattc cgtcaatggc tttaaattca tagcccggat aaataaaaat agatgtccag 2292061 ccgcttgatg ctttaaattg cccgtcatgt tctccggcaa tcgtctcaag cgtgcgtgtc 2292121 gaggtcgtgc cgacagaaat gatccgaccg ccattttctc ttactttgtt taaggctgca 2292181 gccgtttctt ctgacatttg ataaaactct gcatgcatat tatgctcttc cacttcatcg 2292241 gcactcacag ggcgaaacgt tccaaggcct acgtgcagtg tgatgaactc aatttgcacg 2292301 cctttgtctt tcagctgctg taagatttct tccgtgaagt gaaggccagc tgtaggcgca 2292361 gcagcagagc caatttcttt tgaatacact gtctggtagc gctctttgtc atcaagctgt 2292421 tctttgatat atggagggag cggcatctct ccaagggatt caagcacctc gtagaaaata 2292481 ccgtcatatt gaaattccat ctttctgccg ccgtgctcaa gctcttccgt gcagattgcc 2292541 ttcaatcttc cgtctccaaa tgtgacaaca gttccttttt tcacccgttt cgccggtttg 2292601 gcaagtgttt cccatttatc accggtttcc tgtttcaaca aaagaagttc cactttcgcg 2292661 ccggtatcct cttttgtgcc gaataaccgc gcaggcagta cccgggtatt gttcaggact 2292721 agacaatcgc cttcgttaaa gaagctgata atgtgtttaa acgagctgtc agtaagctct 2292781 cctgtatgtt tatcgagcac catcagcctt gaagcatcac gctgctccaa cggtacttgt 2292841 gcaattaaac gttctggtag ttcaaaatca aataaatcga ctttcatgat gatttcacct 2292901 ttattctagt cttttgttat ttcattctgc caaaaagatt aagcaaaatt gataatacca 2292961 cacttataat aatacaagtg acaaccggga agaaaaacgt aacatttcct ttttttacaa 2293021 aaatatctcc cggcatcttg ccgacaaaat gcaaaactgc tccgataata agcaaaacag 2293081 caccaagaat cataatgatc ttaggaaatt cagtcatatc ggggagcctc catttggaaa 2293141 tgatgataaa cggccggtgt cacgatcctt ccacgcggcg ttctttgtat aaatccaatt 2293201 tgcagcagat atggttcata tacgtcttca atcgtatgcg attcctcgcc gatggtagct 2293261 gaaatcgtat caaggcctac tgggccgccg ttgaattttt cgatcatgcc catcagcagc 2293321 ttatgatcaa tatgatccaa accgaggcgg tcaacctgaa gccgctccag cgcattctga 2293381 gaaatgtctt ccgtaatcct gctgtcaccc agcacttggg cgaaatcgcg cacccttctc 2293441 agcaggcggt tcgccacgcg gggcgtccct ctcgatcttc ttgcaatttc aagagccgac 2293501 ggtttatcaa tctcaacctc gaatacatca gcggttcttg tgacaatatc cgccagttct 2293561 tcttgtgtat agtactcaag gcgagacatt acgccgaatc tgtctcttaa aggagccgtc 2293621 aaaagcccca ccctcgtcgt ggctcccacc agcgtaaaag gcggaaggtc gaggcgaacc 2293681 gagcgggcag atgggccttt gccaatcaca atgtccaggc aaaagtcttc cattgcagga 2293741 taaagcacct cttcgatcga tctgtgcagc ctatgtattt catcaataaa taatacatct 2293801 cccggttcca gcgccgttaa tatagcagcc aaatcaccag gcctttcaat cgcaggccct 2293861 gatgtcgtcc gcaattccac tcccatttca ttagcaacaa tcgaagcaag cgttgttttt 2293921 ccgagtccgg gcggcccgta cagaagaaca tgatccagcg tctcctgtct cattttcgcc 2293981 gcatctataa acacgcgcaa attttctttt accttatgct gcccgatata ctgtgccaga 2294041 ttttgcggcc tcaggctttg ctctatcact gattcatggt tgtctgcttc acttgagacg 2294101 agccgttcat ccatgaacat caccttactt taatagtttt tgtaatgctt ttttcacata 2294161 ttggtctgtt gtcagcccaa tttcttcttt aaggtgagga agcacctttt tgatttcttt 2294221 ttcagcatat ccgagaaccc tgagggcttc aagtgcttct tcaagagccg tttccgctgt 2294281 ttgcttttca agcctttctt catgattaaa cagattttca atcatttcag gcacaacatc 2294341 tgccagcttt ccttttaaat ctagaataat ctggcgtgcg gttttctttc ctactccagg 2294401 aaacttgacc aaaaaagctt catcttcatt ttcaattgct tggatgaccg ctccgggatc 2294461 acccgagccc aagatggcaa gtgctccttt cgggccaatt ccggtcacgt ttaacagctt 2294521 tgtaaagagc gccttctcct ctcttgttga aaaaccataa agcgaaaaag catcctctct 2294581 gatatgatgg tatgtaaaaa tcgtttcttg gcttctctcc ttatatataa acggattcgg 2294641 cgtgaaaatc tgatagccga tgccgccgtt ctctatgaca atatattggg gagatacata 2294701 atcaatcgtc cctttaacaa attcaatcac gcaaattcac ctctttgact gttcttcatt 2294761 gtaccataaa aacagccaaa gtcttataga aaagttaaca tatgttcgct tctctctcat 2294821 tctttcacga aaaaaaagac atgaatacat gtcttcaatc agcggacgct acccgctgta 2294881 tgtcttcata tgttcgatga catcctcaaa ctccgctttt gtccgaaatg gaatgccttt 2294941 cagcagattt ttttgcatat ggctttccag cctttctaaa tcaatttgaa aaaaagactg 2295001 aattggttcg gaagctggct caggccgccc atgaaaagtg gaaatcactc cattatccga 2295061 tacaccgata tacccgttga ccttgctgag cggagaaata tcgtccattt gcttccggaa 2295121 gagcacatat cccttttttt gttccactag cgtccatccg gcataagctg cccaaaaatc 2295181 atccatagaa aacacttttt catgcttatg ctcaatgctg acatcgccgt ccaaatacac 2295241 cttttcaagc tgcacatgca cctgcagcgg ctcatagtgc tccacttccg cgccaagtgc 2295301 gcgggaagga gctcctatta aaaatactgc cgctgagcaa agaatgccca gcaaaagata 2295361 cgccgtgctg aatcgtttca ccctctacac ctctttgcac acgtttatga ttagtttgac 2295421 caaagaggct actgcttaac cgttttatca aaatttgtct gcacattttc cctgacaaac 2295481 cgttcctccg tatacacatc tgtgctttgc tcagaaattg tcaagaatcg cgtcagaaag 2295541 gcactgaaaa aatacaatgc cgcaaagatc caaatcacgc cacctgcacc gagcggccca 2295601 atgaaaagac tcacgatgcc cggcgcgata aacgcacata aaccagatcc caaattcaac 2295661 actgacatgg cagcaccttt attatcaggt gcaagcgtcg gcaaaagcgc gcttaatggg 2295721 acgtaccctg ctaaagccgc gccgtagcag caggcgataa tcatgagcac ccaatactga 2295781 tgcccgatca gctgaggcgt gtaatacagc gccagcgtaa aaataccgca tccgacaccg 2295841 ccaaaccaca tgaccgtatt gcgccagcct agtttatctc cgactgcacc gaaaatgata 2295901 ttaaacacaa tattcacaaa aaacagcgtc ccccatattt gcagccattc cgaaaccgaa 2295961 tacccgtatc gtgctaaata agtaggaaga aagatggcaa atccaaattg tcctatcgca 2296021 ttaatcgtct tgaccactcc gccgatgcct accttagggt tttcaaacat aatcgtaaat 2296081 gccttcgaca gttctttcca tttcggctga tcttgttttt gtatcggagt aaatttatct 2296141 ttgttaaaaa ataaggcaag aattccgcct gccgccacaa acagtaaagc gctccaaagc 2296201 gtattgattt ctccaaaggc cggaactgca tagctggaat agaacggacc gagcacgtta 2296261 aggccgcacg taaacataaa ccaaaaccag ccgacggctt ttccaagaat attttgagag 2296321 gtgctgtatg acacccatac gagaaaagag tatgcaaaca gcggatatcc caagcctcta 2296381 agagcatagc tgcccaagag agccggataa tacatatgag gaatcgccca gccgataaaa 2296441 gcggccgaac cgaggataaa tgcaagcaat ccgacagtca tcgtttttct cggcccccaa 2296501 gtttggacaa acgttcctga aagccaagct gagatggtga cagcaatgcc gtacatggta 2296561 aataacgatg cggattgctg catactgaga ccatgatcaa cgagaaaagg agacagccag 2296621 ccttgttcga ggccgtctcc aaccataaag atgacaacgc caatataacc ccaaaccatg 2296681 tgagaaggaa ttccgatttt gttcaaaaca tttcctttag catgtactgt attcattttc 2296741 tccaccgcct acttaaagta tcaatggagt atatacccaa gcttgctgaa ttgtaatcct 2296801 gttagattaa aaagcgattt tttcagtgtg ctcaatgcta acaggcatgc caaaagcaag 2296861 cgattgctgt gctgctctgg cgatcctccc ggcctgtaaa ccgtcattgc cggtgcaggg 2296921 agtctcctgg tttgtgccga tcgcttctgc aaaacggaga atctcctcct catatgaatc 2296981 cttatagcgt tcaaggaaaa agaaatgcgg tttatccttc atcacaaaat cagctgttga 2297041 cacctcaacc gttgtcggcc tgctattgtc agccgctgca gagcctttcg tcccgaaaac 2297101 ctcaacccgc tggtcatatc cgtacacagc ttggcggctg ttatcaatca cagccatggc 2297161 accgttttca aaagtcagtg taataacagc tgtatcaata tcacccagct ccgcaaaaga 2297221 aggattcacc aaagccgccc ctttggcata cacttccgtc acttcgcttc ccataatata 2297281 tctggccata tcaaaatcat ggatcgacat atccataaac aatccgcctg acgtacggac 2297341 ataatctata ttcgggggtt ctgggtcccg ggacgtgatt tttaataaat gaggtgtacc 2297401 gatttcacca ttttcaacaa tcgttttgat tttcttaaaa tgaggatcaa agcggcggtt 2297461 aaatccgact tgaagtgtta ccccgtgttt ccggacagcc gcaagcgctt cactcgtttc 2297521 gtccagagag aaactaacgg gcttctcaca aaatatatgc tttttcgcct cggctgcttc 2297581 tttgatcatc tgtgcatgta cggctgtagg agagcaaata aaaatagcat caatatcagg 2297641 atcatgtaat aaatcacgat aatcagaggt tatgtattca atctgatgac tgtcggccca 2297701 gctttttata cggctcgcct gaatgtcaga gattgctttt attttcatgt gaggaatccg 2297761 gcttatattt tgaacatgaa gtttgccgat gcggcctgca ccgataatcc ctgtcacaat 2297821 ctgttttgtc atggcttctt cccccttgat cattcacgaa agcgctttat ttaaaattaa 2297881 tactatccca tttgtaagcg cttttcaaga atggaaatta aacgttctat gtctctttta 2297941 tcacaattca tgcttataag tagccttctt cttcaagacc agatacacta gaattaggct 2298001 ctttttcctg aacagtttat gattttccta taaacagctg cataaaatag agcaaagaag 2298061 gtgaatgaaa tgctgacaaa agcagaggca ctggcccata ccgtcatata ccgcaagaac 2298121 agcagatttg ataaagtcaa agagaaatcc gaggaattaa cactaatcgg caagggaaga 2298181 agcgcctatg tgtttgcctt aacagaaggc ggtcgaaaaa tggcgctgaa agtatttttt 2298241 ccggaatatc aagcgacagc agtcaaagaa gcagcgatct atgaaaaatt agccgggtcc 2298301 gcattctatc ctgacattta cgaaactggc gattcattta ttctcatgga atatattaaa 2298361 ggtgaaacct tttataactg tctgaagaaa ggcattgcaa tcagtgatga catgattcag 2298421 caggttgaag aagcgctttc tgacgcccgg gcagccggac tgaacccgtc agatattcat 2298481 ttgcggaatc tgatattgac agaaaccggg gcggtgcggg tgattgatgt tgcgagattt 2298541 gagcagacaa aaacatgcac gcagtgggac gacttaaaat ccgcatatca tgcactctac 2298601 aaaaaaccga tattccccaa aaagattccg ggtttttggc tggagatcat cgcattttta 2298661 tataagaaag attggtttca aaagcatttc gcacagcgga aaagaaaata ttcttaaatc 2298721 aaaaaggcag ccgcacaagc ggctgccttt atcatgtatt ttttactttc tgacggcaga 2298781 aatcagtttc atttgttcag gcgacagctt aattcgatag cctctcacag ttaagtagac 2298841 cgcttctggg tccttctcgc cggaatgaca atacgttttt tccatttctg tctcccctca 2298901 ccctttattg gctttatttc atcttatcat tgctttattg aggtaatttt aaagaaatgt 2298961 aaagattata tgaatccgat atatagtaaa atgagagaaa aaaagggaga gagtcacatt 2299021 aagaccgaaa acaccttgag cttagatgca gccagaggtg aacttgtaaa tgaaaaaaca 2299081 cttgtcaaga gaacaatcta ctggaattac ccggacagcc gcccagcagt gacgtggatc 2299141 aatcacaata cagtgaaaat cggcaatcag actttacatc ttgatactga tgaaacgtat 2299201 gattggcgaa aagatgatca ttggatccgt gaagaaccgc cgcaggcgtc agtgaggtga 2299261 tgaaacatga ataagatgaa cggaacaaat gatgaaaagc atttcaatca ttttgtgatt 2299321 gctttatcct ttatatacgg tttgactgaa ctaggctatt tgttgctgaa ggattttata 2299381 acaattgcca taagtttgcc tctgtagaaa aacgcagcgt agtcgatacg ccgcgttttt 2299441 tctttttccc ttcctcttct tattgataat tacaggtcat ataatgtgac aaatcgattg 2299501 tagaaatagt tcgattagac caaaatcctt tttatacatg tattcgaatt tgaagtgagg 2299561 gggaagcttg atggcagatt ttgttgctag tttgaatgcg gtcttatgga gtacgcccgt 2299621 catttatatt ttattgggaa ttggattcgc cttttcaatt atgacccgtt ttttacaagt 2299681 ccgacattta aaagaaatga ttgttcagat gttcaaaggc aagagctctg aagccggcgt 2299741 ttcatctttc caagcgttat cgattgcgct gtccggccgt gtgggcacag gaaacatcgc 2299801 gggagtggcg acagcaattg cattcggcgg acccggtgca gtgttctgga tgtgggcgat 2299861 tgcctttatc ggggcggcga gtgcctttgt agaatcaacg cttgctcaaa tttacaaagt 2299921 gaaacaagac ggtcaatatc ggggcggccc tgcttattat atagaaaaag gcttaggcat 2299981 taagtggttt gccgtcttat ttgccgctgc tgcccttatt gcaatggcct ttctaatgcc 2300041 gggcgtacag tccaactcca ttgcggctgg gatccaaaat gcattcggca tctctccttt 2300101 cgtcacaggg tgcggtctgg ttttattatt agggttcatt atttttggcg gcgtcaaacg 2300161 aattgccaat gcggcgcaaa tgattgttcc atttatggcc attggatata tcctgctgtc 2300221 tttgattatt attgtcatga atgtgtctga attgcctgct gtgatctcat taatattcaa 2300281 aagcgccttc gcattggatt ccgcttttgg cggcttgatc ggtatggcga tttcctgggg 2300341 cgttaaacgt ggcatttact caaacgaagc cggccaggga acaggcccgc atccggcagc 2300401 tgctgcagag gtttctcatc cggtcaagca gggactggtt caggcatttt ctgtttatat 2300461 tgacaccttg tttgtatgtt ccgctacagc tttcatgatc ttgtttaccg gcatgtacaa 2300521 tacccaggct gcagatggtt cctttatcgt tcaccagctt aaaggcgtag aagcaggacc 2300581 tggtttcaca caagcggcaa ttgacagtgt tcttcccgga ttcggtgcag gctttgttgc 2300641 catcgcttta ttcttcttcg cttttacaac aattatggcg tattactaca tcgcagaaac 2300701 aaatatcgcc tatttagcac gaggcagaga aagcaaatgg gcgatgcttg gcttaaaact 2300761 gattatttta gccgccacgt tctatggtac tgtgaaaaca gcttcacttg cttgggcatt 2300821 aggggatgca gggcttggca ttatggtatg gctgaacgtc attgccattg tgctgcttgc 2300881 caagccggcg ctccttgctt taaaggatta tgagcgccaa aagaagcagg gcttagaccc 2300941 gatctttgat ccaaaagcgc tgggtatcaa aaacgctgat ttctgggaga aagaatacac 2301001 tcatgaaagt gaacgtgtct cctgaacata ctaaaaccgg cccgatatga cctcgtgccg 2301061 gttttttatg aacgatagtt tgtatacact tcttgaacat catcgtcatc ttcaaggacg 2301121 tctattaatg tttccagctt ctcaacagcc tgatcatcgg cttctgcata ggtattggga 2301181 agcatggtca cctccgccga agaaattaga tatttcgatt cgagggctgt tttcacctct 2301241 tcaaaatgct caggctctgt gaaaacctca tataggtctt cttcaattcg cagctcttct 2301301 cctcctgctt caagcacatc aagcatgagc tcatcttctt ctatttgccg ttcagtacgg 2301361 tctatcgtaa tgaacccctt tcgttcaaat aaaaaggcta cacatccgct ttctcccaga 2301421 cttccgccat ttttattaaa ggctgtccgc acatttgacg ccgttcggtt tttattatct 2301481 gttacgcatt caaccatgac ggcaatccct gaagggccgt agccttcata ggtgatttct 2301541 tcatagctgc ttccgtcttg gcctcccgca gcttttttaa tggcccgatc tatattttca 2301601 ttcggcatat tggcgccttt tgctttttcg atgacaagac gcaatgctga atttgcttct 2301661 ggatccgctc cgccttcttt cgctgccaca tagatttctt ttgccagctt cataaatatt 2301721 ttcccgcgct ttgcatcctg tgcatttttt cttttttgaa tgtttttcca cttggaatgg 2301781 cctgccatgt tttcaccttc ttttacattt tctatgtaca ctttaatggg aaatgttcgc 2301841 tgatgcaaag aaaaaggctg ccgaatatca cttccggcag cccttccttc ctagcggttg 2301901 ttcattttat gaagttttct gaacagccct ttatctgttg atacttggac gtcacggcca 2301961 tttgcatagt tgcgcgctgc ttttacaaca ttatctctgt cagactttgt gaactctctg 2302021 tggcttttga ctgcgataac tactcggtca tccgatacca taacttgtgt gtcattgacg 2302081 tttttcactt gtttcacacg gttggcaatt tttgcagcca gtcttctgtt ttcttggttg 2302141 tcatacccgt tgttcgctgc attccgattc atgtttcggt tattcgtgtt gttatatgtt 2302201 ccgtcagttg ccaaaggaac acgatcgtca gcagtaacac ggtcacggtt atttacattc 2302261 gtggtgtttc ggttaccgtc gttctgatcc tccattaatt cagaaacagg accatcgtgg 2302321 tcgattccgt ctccctgtct atcggcgtca ttttcatttg tataatatcc gattggacgg 2302381 gtattgccgt tattgcgcgt atcattcata gcattatcgt ttgctccgca tgctgttaag 2302441 ccggctgtca ttagaatcag gctagcgatc gtcatttttt tacccaatgg aaaaaccccc 2302501 cgtggacgaa ttgagcatgt ttgctcgctt ttatcatgtg cgtatggggg gcatgttaag 2302561 cgtgtcagtt ctctccattt ggcagtgatc tgcttgaaaa caaaaaaagg aacgatttac 2302621 atcgttccga acgatcactc attttcttct tccggacggc caaacatttg gtttacagaa 2302681 ggctggttcg tcattggcat agaaactcct gccgaatatg ggtttggatt tgggttagct 2302741 gtgccatatg gcatattagg gcttccataa gctcccattc ccgaatggcc aggtgcagag 2302801 aaatatggct gatgatcacc gtcacagccg cagtcgtcat gatctttgta tggcatgtaa 2302861 ccatgagccg cagcaggctg gtatgctccc attacttggg gagtgccgta ataagggcca 2302921 tacggcatat gtccatacgg agatccataa gccggagatg cgtattgcgg cgcaccgtat 2302981 gaaccgtaat gtccgtgatg gctgttttca tgatgctggt tttcataacc cgggtcatac 2303041 tgaggcgata caaagcctgg ctggtatcca tgcatcggat gcattggata agcttgtgcc 2303101 ggatagtacg gatagcataa tcctgatcct ggaagaattg gcgaaacagg caccggacac 2303161 ggtacgaaat gagccggata atgataataa ggctgaacag ccggcatcgg catattcgga 2303221 actgtgtgat gaacgttttc ctcttctata ccgcctacct ctggcgcctt tggcatatta 2303281 ggcatattcg gataatttgc attttccata ttactcatag cctcctgttg tggaaattgg 2303341 tcttgcatat gatacatatg atccatattt ccgtcatgat gttttttcgg ctcctccggt 2303401 ttaggaggcg accaaggctg gaaaagctgt ttcatatcat aataatcgtt cacatcagct 2303461 tcagggtaca cattttcctg caaattaggc atcggcggga catacggcat ggacttcttt 2303521 tctttcggct ttgtgtcttc tacatcgaca acggatttag gcttctcttt cgcatatgga 2303581 tgttcttgct tcacactccc ggccgcagga cttttgcccg cttttggctc ttttctgacc 2303641 gggactcctt ctgacggcac ttttattttc attccaggca tgattaagtc tggattgcta 2303701 agctgtgtat tgagtttttt cacttcctca acatcgactc cgtacttttc agctattttc 2303761 cagagcgaat cgcctttttg aacgatatgg attttcaacg ttttcccctc ctatgcaaaa 2303821 cgtgaacagt tcagctgtga ttacaatatg tttcttcaca acatatgcct gaacaaaaga 2303881 agttatgagt aaaggaaggg aaaatatttc tgatctacgt gatcgaaagc attcgattca 2303941 gggcaaggag tgcatcttcc tgaatggctt ttggcacctt gatgacgcct gaaggttctc 2304001 ctttttcaat ttgttccagc gaccacaaca aatgcggcaa atcaattcgg ttcattgtca 2304061 ggcaagggca catgtcaggg ttgagtgatt cgatttgttt atctggatgc tcgtgaatga 2304121 tccgctgaac aagattcatt tctgtcccga ttgcccactt gcttcccgcc ggagcctggt 2304181 tgattgtgtc gataatatat ttcgttgatc cgttatcatc gcttagtgtc acgacttcgt 2304241 gtgaacattc cgggtgcaca atgatctgaa tgtcggggtc tcgctctctc atatcatgga 2304301 tatttttagt ggtgaatttc tcgtgaacag agcaatgccc tttccacaaa atcactttca 2304361 cattcgtatg cccggattca gctactaatt catctttcat cggatcccac acagccatat 2304421 cttcaagcgc aatgcccaga tcataagccg tatttctccc taaatgctga tcaggcaaaa 2304481 ataaaattct ttttttctgt gtaaacgccc attcaagcac ttttttcgca ttcgaagaag 2304541 ttacagttgc tccgccatgc tttccgacga atgccttgat ctccgcagtg gagttcacat 2304601 aagttaaagg tatgatcgta tctccaaata tatgctgaag cttcttccat gccctattgg 2304661 tctgctgcat gtcagccatg tcagccatag aacatccagc tctcatatct ggcaggacga 2304721 ccgtttgctg ctcgcttgtc agcatatcgg cggtttctgc cataaagtga acgccgcaaa 2304781 atacgatata atccgcttct ttgttttttt ccgctacttg ggccaattgc agggagtcgc 2304841 ctgtttggtc agcaaattgt atcacttcat ccttttgata atgatggcct ggtataaaga 2304901 gcctgctgcc gaactttttc ttaatggcgg caacgcgcgt ttccatatcc tttctcgata 2304961 gttctttata actttcgggc atcatatcat tcgattgttt gatcacatca agaattgaca 2305021 taacagcatt cctccacaga ttcatttgat aacgtaacat ccatgctgat atctaaactt 2305081 ttgacggaat gagtcagaaa tcctaatgaa atataattca cacccgtccc tttaaaagca 2305141 ggcaaagatt ctaacgtaat cccgccagag gcttcagttt ttatattagc cggtgtgagc 2305201 tttgcaaaat gacggaccgt atcaggcgga cagttgtcaa acataataac atccgctcca 2305261 gctgcaattg cttcccgcag ctgttcctcc gtttcaattt ccacctcgat atttaccatg 2305321 tgccctgcgg cctgacgggc ttttttgcac gcctctaaaa tagagccgca tgctgcgata 2305381 tgattatctt taatcatgat gccgtcatac aaaccgaatc gatgattata cccgccgccg 2305441 gctctgacag catatttctc cagcattctg agccccggtg ttgtttttct cgtgtcacaa 2305501 attttaatct gttcatcatc cagacaccga acagcctctc ttgtcattgt cgcaattcct 2305561 gacagcctct gaataagatt taatacgacc cgctctcctg aaaggagcgc agctgcggga 2305621 ccgtgtaact cggcaatcac ttcaccttta tgcaacatgt ccccatcttt tttgtgtaaa 2305681 atgctttgaa cattttcgtc caataacgaa aagccttctt ttatgatcgc tgctcctgca 2305741 aaaataccct ctgactttgc aacaatctcc gcttcacagc tctgttctcc aaaaatagac 2305801 tgcgatgtaa gatcccctgt cccaatatcc tcaagaaaaa agtgattcag taattttttc 2305861 agctgtaaat gattcattgt tccaaatccc ctcgtttttt ctgatcttcg ttcctttttt 2305921 tgtatggaca atttgtcttc cttgccagct cacctcagca tgaggaaaat cggtgcggaa 2305981 gtgagcccct ctgctttcct cccgcaaaag cgcagaaaac gtcatcagct ttgcagtttg 2306041 ccatagatga gaaagttcca tctgccgaat tgtgatatcc ttcacattta cttcctgaaa 2306101 aggcagcgta tgaagccaga tgctaagctc aatcaaactg ctttgttccc gcagaataga 2306161 catgtggctt gtcattttgc tttgcagttc atgcccctct atatccggca cctcgtagaa 2306221 gacactggtt tctagccctg attgatattg cctgttataa accggttttt ggataatatg 2306281 ctctgctgcc ctttttccaa ataccagcgc ttccaataaa gaattgcttg caagccggtt 2306341 tgctccatgt aaaccggagc atgctgtctc gccaatcgca taaagccccg gcactgtcgt 2306401 ttctccccag cgattaactg aaacacctcc cattaagaaa tgcattcccg gagcaacagg 2306461 aatttttccg ctgtggatat caatccctgc tttttcacaa atagcggtga tggtagggaa 2306521 acgcgtttca aaatcagaaa tcgcactgaa gtctatataa acgcgatttc cttttgccat 2306581 ttcttcgtga ataacccgtg agacaatatc tcttggagcc aggtcaccta aaggatgccg 2306641 ttcagccata atcctgcggc cgttttcgtc tactaaacat ccgccttccc ctctgacagc 2306701 ttctgaaaca agcccgtagg aaacaccatt tttcacaagc agtgtcgggt gaaactgagt 2306761 aaactccaaa tccgttaatt ccgccccggc ccggtaagcc agagaaagac cgtcacctgt 2306821 gacagtgaga tcattcgtat ggtgaagaaa caggtttcca cagccgccgg cagccagcac 2306881 aacttcgtct gcgtgcctta ccttgagccg ccctttgctg tcttttgtca tgacgccgat 2306941 acatcgtccg tcctctataa gcaaatctgc tgccgtttca ttctcgatta acttgatttt 2307001 gctgttgatc cgtttgagca aataatcgat aagcagcctg cctgttgcgt ctccgcctgc 2307061 atgaaatatg cggttgtatg agtgggcccc ttctcttcca agacaaacac cgcctcgttc 2307121 attgcggtcg aatggaaatc cacgctccaa taggctttga accatcattt ttccatcatg 2307181 taatacgtct gctacaatag ctagattatt atggccgcac cctgcgtata acgtatcctc 2307241 cagatgggct tcaatcgagt catcttttgc ataggccgca gcaatcccgc cttgtgcata 2307301 gacagaattg ctgtttttga cgcttttttt tgtgataaca gtcacttcgt atgagggcgg 2307361 gaaagctgca gctaaggaaa gtgccgccgc ccctgaaccg atgactgcaa tcgtcttttt 2307421 agacatatgc catcctcctg ttgtttacac ctgtcttgac acctatattt acacaaggat 2307481 aaaataaact caagagtttt ttatggagaa cggatggagg aagaccggat gatttattta 2307541 gattatgcag cgacaacgcc tatttgtgag gaagccctta ctgtatatca gaagcttagt 2307601 atggatatgt acggaaatgc cagcagcctg catgatgcag gaggaaaagc aaagcacata 2307661 ctggagtact gccgtgaaaa aatcgccaac atcattggcg gagaagcaag cggcatctat 2307721 tttacaagcg gcggcactga atccaatttt ctggccattc aatcattgtt aaacggcctg 2307781 ccaaaaacga aaagacattt tattacgact gccatggagc atcagtccat tcataattgc 2307841 gctgcttttt tggaacagca gggatatgat gtaacagtca ttgaaccgaa tgaatacggg 2307901 cttattaccg aggaaatatt actaacccat atccggccgg aaacaggcct tgtatctatt 2307961 cagcatgcaa attctgaaac cgggatcatt cagcccattc aacacctgtc ttcatacctg 2308021 cacaataagg ggattcttct tcattgcgac gctgttcaaa cgtttggaaa gatcccgatc 2308081 aatacaaaaa atctgggagt agatgcactc tcaatgtcca gccataaaat ccacggtcct 2308141 aaaggagtag gggcggtcta tatccggccg gatgtccctt ggaaacccgt ttatcctctg 2308201 actactcacg aatacggatt cagagccggc accgtaaatg ttcccgggat cggtgccttc 2308261 actgccgctg cagaattgat cgtaagcgaa atggaaaaac agatatcccg caatgaggca 2308321 ttaagaacat actttctaga ccaaatccgt attcggtctc tccctgtaac ccttgcagca 2308381 gacacttcga aagcagaatg tcttccgcat attatagggt gtttttttca ctcatttgaa 2308441 ggacaatatg ttatgttaga atgtaatcgg agtaatattt gcatttcaac cggcagcgct 2308501 tgttctgcag gttaccacgg tccgtctgaa acaatgaaag cattaagaaa aaccgaacaa 2308561 gaagctctgc aatttatccg catctctttt ggcaggcata caacagctga acagctggaa 2308621 cagttattac atacgtttac agtgctttgg gaacaaaaga aaggagaatt tgatattgac 2308681 cgaagaatta aagctaatgg gcgccaacag gcgtgaccag cttcttctgt ggctgaagga 2308741 atctaaatca ccgctgacag gaggagaact cgcaaaaaaa gcgaacgtct caagacaggt 2308801 tattgtacag gatatatcgc tcttgaaagc gaaaaatgta ccgattatcg ccacaagcca 2308861 aggatatgta tacatggatg cagccgctca gcagcaccag caggcagaaa gaatcatagc 2308921 atgtctgcac ggtcctgaac ggacagaaga ggaactgcag ctcatcgtcg acgaaggcgt 2308981 tacagtaaaa gacgtaaaaa tcgagcatcc cgtatacgga gatttaactg cagccatcca 2309041 agtaggcacc cggaaagaag ttagccattt catcaaaaaa atcaattcta cgaatgctgc 2309101 ctacttatca cagctgaccg acggcgtgca cctgcataca ctgacagcac ctgatgaaca 2309161 tcgcatcgat caagcctgcc aagccctcga agaagccggc attttaatta aagactaaaa 2309221 aaagccctct agtgggcttt ttttataatt ggtaagactg gtatgcaccc agaagcctca 2309281 ctttgcagcc gagtgcttca agctcctgca tggcccctgg aatcaataca tcatcaaacg 2309341 ctttctcaat atcaataata aagaaataat ggcctaatcc ggttttagtc ggacgtgact 2309401 caatttttga caggtttaaa tttctccaag aaaatgcaga cagcactcta tgcagcgccc 2309461 cggactgatc atcctgcggc agcatgacca ttaaggtcgt tttgggccta gagctcaatt 2309521 ttgaattcac ttcaaaagat atgttttcat cgggagacag gataacaaat cttgtatgat 2309581 tgtccctata atcctgtata tcccgtttca cgatttttaa ttcgtatgta gaagctgcca 2309641 tatcattggc aatgaccccg atattcagct cgggatggtc actgacaaac tttgctgccg 2309701 ccccggtaga attggcgtat tcatatggaa cggaaggaaa atgtcgatga agaaatttat 2309761 ggcattgcgc aatcgcgtgt gaatgtgagt aaattttgtc gagctctttc catgcattct 2309821 ctcttgaggg atggacgagc aagtgctggt gaatcggcaa cgtcatttca cccacgattg 2309881 gcaaaggctg ttcatgtatt aaatagtcta ttgttagatt aacagatcct tctaaagcat 2309941 tttccaaagg aacaaaagca aaatcaactt cgcctgcaac ggctgcatct atacactccg 2310001 gaatggtgcg gtaagcaaca tgttcggcgc cgttttgaaa acaagaactg actgctagat 2310061 gtgtaaatgt agctgctgga cctaaataac cgactttcat gacgattttc tctcccttat 2310121 gcacctgaac ctaatatttc aaccttttct acaaaatcaa acttcctgag cttattcatt 2310181 aatgtatgaa tgtcttcttc cattgccgac gtactgatag acagtgtcac atttgctctg 2310241 ccttgaagcg gaatggtctg gtgaatggaa agaacgttgc ttccagaatc agctaccgcc 2310301 tgaagaagct gagataacgc acctgaccta tcctccaaat gaaagaaaag tgtgataatt 2310361 tgttctttta ccatggtgta gaatggaaaa acagcatccc tgtatttata aaacgcactt 2310421 ctacttaaat cgaccttttg aacggcatct gctactgaat ctgctttttt tcgatcaagc 2310481 agctttttga cttctaatgt ttttctcatt gcatcgggca atacatcttc acggacaaga 2310541 taaaatgtct cctctttcat ttgcatcccc cctttaaaat agagagcctg gcaccaggct 2310601 ctcttttcag ccaacattga ttaatcaata aattcaaatt caaattccag aagcctgatt 2310661 atatctccat ccttggctcc gcgttctctg agtgcttcat caacacccat tccgcgcatc 2310721 tgtcttgcaa accgtttaac cgattcatca cgtgagaaat cagtcatctt gaataaccgc 2310781 tcaaggctgt ctcctgaaag cacaaataca ccgtctggat cgcgtgtaat gttaaatggc 2310841 acttcttcat tttccatcgt gtacatgaca cggttttgtg taagctcttc ctcgtcatac 2310901 agcgggaatt ccggtgtgtt ctcaagctga ttggcaacct caaacagaag ctcacgcaga 2310961 ccttctcttg tcaccgcact gatcgggaat accggataat catccgtcag cttttcttta 2311021 aaggcttcga gattttccgc agcctccggc atgtccattt tatttgcaac gataatttgc 2311081 ggacgctcag tgagacgcag attgtactcg ctcagctcct ggttaatcgt aagataatca 2311141 tcatatggat cacggccttc taagcctgac atgtcaatga catgaacaat aaccctcgtc 2311201 cgttcaatat ggcgcaaaaa ctggtggccc agtccgacgc cttggtgtgc gccttcaatc 2311261 agccctggca aatcagccat gacaaagctg cgtccgtcat ccgtttcaac catgccgaga 2311321 ttcgggacaa gcgttgtaaa gtgatagtcc gcaattttcg gttttgcaga tgagacaaca 2311381 gacagcaaag tagattttcc cacactcggg aacccgacaa gtccgacatc tgcaagcact 2311441 tttaattcaa gaacaatgta gcgttctttt cccggctcgc cgttttctga aagctgaggc 2311501 gcgggattag ccggtgtagc aaagcggcta tttcctcttc cgcctcttcc gcctcttgca 2311561 atgacagccc gctgtccgtg ctctgttaaa tcagcgatga cctgttttgt atcatcgtct 2311621 gtcacaacgg tgcccggcgg aactttaatg accatatcat cagcatttcg cccgtgctgg 2311681 tttttggaca tgccatgctc gccgcgaatc gctttaaagt gttttttgta tctaaaatcc 2311741 atcagggtgc ggagaccttc atctacttca aaaacgacgt ctcctccctt tcctccgtca 2311801 ccgccggcag ggccgccttt cggcacatat ttttcacggc gaaacgcaac cataccgttg 2311861 ccgccgtcgc cgccttttac atatactttg acctgatcta caaacataat gtcctccgtt 2311921 ctaaaccgtt aaaaactccg ctagtccaac ccaatttcaa tcagacattc gtgactcgtg 2311981 atttcaaaac gcatgatatc aacgtcctca tatccattct gccgaatatc atcaaaagca 2312041 gatggatcgg caaaggcgcc gtgaaaatca aggtacagaa tcagctgtct gtcaggatga 2312101 tccgtttgaa gcgaaaccgt taaatgattt tcactctctc tgctgactgc ttgatcaaac 2312161 agatgaaaca gctttctcat cagtttcgcc agcttttgat cataagccga caaatcctta 2312221 atttctccga gaacttcata ttcaagcgtc atataatggg ttttccaatt aaacgtaaga 2312281 aaatcaaacg ccaaatgcgg tgttttcagg tttgagagct ttgattcgtg ctttgcgtct 2312341 ataaccattt cttcaatcat ttcaaagaca cggtcatact tctgtaagct taagtttcct 2312401 ttaatcagct gcagcttatt catccaatca tgccgggaat ggccaagcag atgaatcagt 2312461 tcgtttgtta atgccgtgtc gcttatattt tcttcttgat tttttgaaac atccttcatt 2312521 ttcgcactcc caatcattta atttcttatt taggagtctg tataagtgtg tattatgaat 2312581 tataacagag aaggctttgt tagaaaaaca attgtttttc ccagaaatat catgttcctt 2312641 ttttctggct ttggttgatt tgcagccagg cagaacattt tatgtattac tgcttgggga 2312701 acatatccag tgggtttgag atgtttattc tcattcttgg cggggtctgc tcgcacatac 2312761 tctgcatttc attctaggtg tttactccgc atattgcaaa aaaaactcca gtcatcatcg 2312821 accggagttt tttgaatcat tattgagcta caggatatac gctcactttt ttgcggtcac 2312881 ggccgaaacg ttcgaattta acagttccgt cgattttcgc aaatagagtg tcatctccgc 2312941 cgcggcccac gttttcacct gggtaaattt ttgttccgcg ttgacggtaa aggatagaac 2313001 cgcctgttac gaattgaccg tcagcacgtt tagcacctaa acgtttagcc tcagagtcac 2313061 gtccgttctt tgtagaacct actccttttt tagaagcgaa aaactgaaga tctaatctaa 2313121 gcatgtagct cacctcctat attatgtttg tggtcacacg caagttgtct ttgtaatccc 2313181 gttcgattgt ctccagcgaa acaatcatgc cttcaatcag cagctgagct ttttggcgtg 2313241 cctctggatc aagagattca gggaattcaa aataaaaata acccccgtcc tctcctatat 2313301 caagaagcgg ctcgaagccc gcgagcacaa tgaccgcgtt aacggcccca aacacaacgg 2313361 ctgtcactcc ggcacaaaca agatcttgtc catgttcagc aaaattcgca tggcccgtca 2313421 tttcaaaaga caatatgcct ttatcatgag accttctgat tgttgcctga atcatgctta 2313481 cgcgttgatt ttttcgatcg tcactttagt gtaaggctga cgatgacctt gttttttatg 2313541 aacgtttttc tttggtttgt atctgaaaac agtgattttt ttcgcgcggc cttgtttttc 2313601 aactttagcc gttactgttg cgccttcaac tgtagggttg ccgactttca cgttgtctcc 2313661 gccaacaaac aaaacgtctt caaaagtaac tgtttcacct gcttcagcag caagtttttc 2313721 gatgtaaaca gtttggcctt cttcaacttt gatttgttta ccgcctgttt taatgattgc 2313781 gtacattctc tgcacctcct attagactaa gactcgccag ataccagggg gctgtaaaag 2313841 ctcttaacac ctgtactgag cggttgtagc aatggtgcta catccataac attaaaaaat 2313901 ataccaaaat acaaggcgtt tgtcaatcag ttttagtagg gcagaagcag ttcctccatg 2313961 gaagaattcg tccgcttatc ggcaaagtaa gcgtgcagca cttcattctc gtcaagctgg 2314021 ctgagctttt ggcctgattt ttctataata atcggatgct tacagccacg tttgaactcg 2314081 gccatcacat gatagacttt atcctccgcc tttactgtca gcggcagaag tttctcaagc 2314141 tccctgtttt ttccgtaata cctttcgagg agaaatctca catggatata gtgcctttgc 2314201 cgatattcct caaacaagga aacagccaga aagacaaaca aaacccatgc gctgatttgc 2314261 agaggaatca cgaataaaac ccagcacccg agcagcaggc agaagcagag cgacgttttt 2314321 agattaagcc ggtgagcctt ttgaaaaggc agctgtttgg aaaacaacaa aaataacagt 2314381 tttcctccat ccagcggcca gatcggcagt aaattgacaa ataagataga aagattataa 2314441 aaggtgaaga gttcaaaggt atgctgatga atcactgaga cttctgcaag catccaggcg 2314501 gcaaactgaa gccagatgtg ctgaagaggt ccggcaataa tgaccgcaaa ctcttccttt 2314561 aacggccgat tcccgtgctc ttccacttcg accgttccgc caaacggcag caaaaaaaca 2314621 cgcttgattc tccaagaaaa aaacacagcc agagcagcat gccccagctc atgaatcaat 2314681 acaatcagga gcagacataa taatgctttc atatggcctg tgagcaagcc cagcgccgca 2314741 ataatccaaa gaaaaggatg cacatggatc tttaagataa ggtcgagcca tttattcaaa 2314801 tgaaatcacc tgaatcggat caataaattt atcgccgtct ttcatggcaa aataatagac 2314861 ccctttatta tgatcatcaa gcttaatcga accgagcttt ttgcctttat ccacaaaatc 2314921 atataaagca acatccacat ctttgagctc gccatagata ctataggtgt tgtcagcatg 2314981 ctgcacctta accgtcagtc ccgtttggct gtctttgctg acttcaacca catagccttc 2315041 ttttacgcta tcaatcttat cactgcttgt ttcgacttta attccttccc cattgtcctg 2315101 aaaatcctgc tgtactttcc cggatgcagg cgcgatcaga tctttgccta cttcaatctg 2315161 ctgttcctta tttttgtgtt caggagccag gaaagcaagc ggatttccga atttggtttc 2315221 gaaccaatgg cttgctgaag caaattgaaa ttcagtttca aaggttttgg ctacggcggg 2315281 tttaatctga ctgacgggtc caatgtttgt tttataggct atagctgaaa cgagaacaag 2315341 gcaggccgac agaagacatt tcaggataat tgaatctgtt ttcaccaatg ggtgttttcc 2315401 gttgaatgtt ggcatgttat cttcgtagac cggaagtgtt ccatgctttt cctgatccgt 2315461 taccatcacc caggacgggg gtttctgctt ttcagaaact gtctgagtag agaaacgttt 2315521 tgagccggaa agctgctttc ttcttttctc taatcgtttt ctgatttcat ctgctctgtg 2315581 actcattgcc atcatccttt gcattcgttg ggtttgtaca tcatatgtct tgtccatggc 2315641 aaatattcgg tttagtcaag aacaaagcag gcaaaaacaa aaaaaacctg acacagcata 2315701 tgctttgtca gattcttctc tttgattcta tcacattaag atcttactcc gaaaaatgac 2315761 ttaatcttag ccatcattcc tttgttttgc tcttcaagca cctgtaaagg aacagattca 2315821 cctaagatgc ggcgggcaat attgcgatat gcaatggaag cgcggttttt agggtccatc 2315881 gcaatcggtt cgccatgatt ggaagcttta atgacttcat catcatcagc cacgattccg 2315941 agcaaatcga tcgacagatg ctgtacgatt tcgtcgatat ccatcgtgtc accgtttttc 2316001 atcaggtgat ttctgattct gttaacaacg agccgcggcg gttcaatatt ttcctcttgc 2316061 tccagcagtc ctataatacg gtcagcatca cgaacagctg agatttcagg cgtagtgacc 2316121 acaatcgctt tatcagctcc ggaaacggca tttttgtacc cttgctcgat tccggcagga 2316181 cagtctatga tgacatagtc aaattcctgt ttgagctctt ggaccatgtt tttaatttgt 2316241 tcaggagcaa cagctgtctt atcgctcgtt tgagcagcgg gcattaaata gagcagatca 2316301 tcgaaacgtt tgtcttttac gagcgcctga tgcattttgc atctgccctc tacaacgtct 2316361 accagatcgt aaataattct attttcaaga cccattacaa catcaaggtt gcgcagtcct 2316421 atatcagtat ctactaagca tacgcgcttc cctaaaatgg ctaaggcggt accgaggttc 2316481 gcagatgttg ttgtcttacc tactccgcct tttcccgaag ttattacgat agcctcaccc 2316541 aattcacatt cctccctcaa gccttgttag atcaggtctt aaatgagcca aatgttgaag 2316601 gcgttcaatg accatatttc cgtctgtatc taaataagca cattccattt cgttcccttt 2316661 ttgaatgtgg tctggggagc gatttaacac atgattgatt cttaattgtg tcggaagcat 2316721 ttcagaggcg gcgatgaccg cttgattatt tccattgaat ccagcatgcg caattccttt 2316781 cagtgagccc agaacaaaaa tgttccctcc ggccctgact gttccgccgg gattcacgtc 2316841 accgatcagg agcaagtcgc cttttacctg cagcacttgg cctgaacgga caatttttga 2316901 aacagaaata atttcggctt cctctcttat ctgctgtgct tcttttttag taatgacttc 2316961 actgtcaata gaatgaacaa acaaatcttt ctttgacgca atcaattcgg ttagctgttc 2317021 ctcttgctcc ttatataaaa agcgatttcc cagcttaaca tgaacgctga ttttctggcc 2317081 ttttccatcg gtatattgtt caattgacag catattctga agaccatcga gaagctcatc 2317141 aaaagaacac gcatcatcca gatgcaatgt tagtccattc tttgttcctt ttattgttac 2317201 atattgctgc tttttggtct tcacaatatt cacctcaaca acatactcat ttcgtcaaaa 2317261 aaagataaaa tcctttttac tcatctctca attctttctt tagactcata aaaaacaatc 2317321 taaatggcag aacaagaata agagctgctg caatatttaa taaaattgtc ggtataaacc 2317381 ggtcaagcac aaatccgtta aacgtcataa tgtctttatg aatcaaagac tgaatgccga 2317441 atacgtaaaa ttcgagcaga cagacagcca gaactgctat caatatcact acaaatgcgt 2317501 ttgtatgcaa cactttaaac gcttttgaag ccaaatagca tagccctgca aaaccaaaca 2317561 tgtaaacgcc taatagactt gtatagttca tgtcatatag aaagccaaaa ataaatccgt 2317621 aaatcatcgc gtgtttttgg ttgataaaag ccgacatgaa tatcaataca agcatcaaaa 2317681 aacgcggggc gagcacttgg tcatctgtaa cgaaaggaaa atgcaccaaa tctgtaaaaa 2317741 tgctttccgc agaaaaaaca agcatcataa cgaaagggag aaggaaacgt ttcacgatcc 2317801 ttcctcctct gtatcgacag tcggcacgtc acggttaaca acgatcacat tatttaaatc 2317861 tgtaaggtca gccgcaggtt ttacataagc aaccttcgtt aatccatagg aatctgactc 2317921 gatatcagtc acttcaccga ttgtcagccc ttctgggaaa acaccgcctg tccctgatgt 2317981 ttcaataaga tcgccttttt tcacgtcttg tttatcctta cgctcaataa ttgtcatctt 2318041 aagacgtttt ttctctttgt catatccttc gatcaagccg tagcctttgc tgcctttttt 2318101 tccggaaatt tttgtcgcga ctctgttatt gcggtcagta tcgcttaaaa gctgaacagc 2318161 agacgtaaaa ttgttaagtc cggagctttt gatcttgccg attaatgcgc ctttttcgtt 2318221 tgtaacggcc atatctttcg ctacgttttg ctgagtcccc ttgttaatgg tgacctgttt 2318281 cgcccaatta tcagggcttc tggcgatgac cgttgctaaa atcggcttgt aatctttaat 2318341 cgatttgaca tggccaagct cgtcacgcaa ggatttgttt tcttcttcaa gctcttgaag 2318401 cttggcttca tattgtgtct gtccgtcaag tttttctctt agacgctcgt tttctttgta 2318461 tgtgtttttt aaatcattga tgttctcaaa tattcctgca aaaaattcgg caggcgtatg 2318521 aaaaatattt tgaaatactc ccgtcgtatc gccgatcact ttctcaggcc aggtggtatt 2318581 gcggccgccc ttcagcgaaa atccaatcat agccaccaat atgataatac acagaagtaa 2318641 tagcattaac cgcttattcg gcatcgtgtt acacctcttc tattgaactc ccgattatct 2318701 agttttccct ttgaaaagat ggatgtgctc cagtgctttc cctgttccga tcgctacaca 2318761 atcaagcgga tcttcggcga taaggaccgg catttttgtt tcttcgctga tgactttgtc 2318821 caaattgcgc aaaagcgctc cgccgccggt taacactata cctctgtcca tgatatctgc 2318881 tgcaagctca ggcggtgttt tttcgagtgt gctcttcact gcttcgacaa ttgtagatac 2318941 agtgtcgcgt agagcgttag aaatctcttt tcctgtaatt tcaattgttt tcggcaaacc 2319001 tgtgagcaaa tcgcggccgc ggatttccat gttgtcggat tcttcaggag cttctgcaga 2319061 tccgatttcc attttaatcg cttcagccgt acggtcaccg atcatcagat tgtacgtttt 2319121 tctgatgtag ttgataatcg cgtcatccat ctcatcaccg gctacacgga ttgactgaga 2319181 cgttacgatg cctccgaggg aaataatcgc aacttctgtc gtaccgcccc cgatatcaac 2319241 aaccatgctt ccagtcggtt cccaaactgg cagattggct ccgattgctg cggcaaaagg 2319301 ctcttcaatc ggatacgcgt cacgcgctcc cgcctgtctt gtcgcatcga taacagcgcg 2319361 ttcttcaaca gctgtaatgc ctgatgggac acataccatt acatatggtt ttctggcaaa 2319421 catgccttta ttttttatgg cctgattgat gtaatatttc atcatcgtcg ccgttgtttc 2319481 ataatcagcg ataacgccgt ctttcatcgg gcgaagagcc accacgttgc ccggtgtccg 2319541 tccaatcata tttttcgcat catttccgac agcgacaatc gatttcgtat ccgtctgcaa 2319601 agcgacaact gacggctctc tcacaacaat tccttttcct tttacaaaaa caagcgtatt 2319661 cgcagttcca agatctatac caaggtctct agcaccaatt ccaaacatat gtatgtatct 2319721 tcctttctta aagcaaaaat accctaaagg gaaaaactca taaactctat tatagcttaa 2319781 ttcgacgaaa aaaaaagtgt tacaaatatc ctttttcctt taaactcaca aattttttat 2319841 ccccgatcac caaatggtca agcagctcga tgccaatcag gtttccgcat tcaaacagcc 2319901 gtcttgtcac ttcaatatct tccctgctcg gcgtcggatc tccagaagga tgattatgaa 2319961 cacagataaa ggaagcggca gatcgtttaa acgcttcttt aaacacctct cgcgggtgga 2320021 caatagatga attcaggctt ccgataaata cggtgcgttt atggatgact tgattttttg 2320081 tatttaagta taaacagaca aaatgctcct gggttaaaaa gcgcatatcc tccatgacaa 2320141 gattagcgcc gtcttccggg gagcgaataa cgaaatgttc ttcgttggct aatttatgaa 2320201 tccggcttcc aagctcaact gctgccagta tttgaatcgc ttttaccata ccgattcccg 2320261 ggatgcttga cagctcttca accgatgctt ccttgagcag gcgcagcccg tcaaatgagc 2320321 gcagcagccg gtttgacagg tccaaaacag attcgtgttt agtccctgtc cgcaataata 2320381 tagccaaaag ttcatgattc gctaagttct cggctccgac tttcaggagc cgttcccttg 2320441 gcttttcttt cattgggaaa tctttgagtt ttaatggcag atcgtgtatg accaagcact 2320501 ccttttcttt cccttcccgt ttatagaacc gtcatgccct tatatcaaaa tggcgaagag 2320561 ctctcattgt ttttgatata ggaaggccca tgactgaata ataatctccg tctattttct 2320621 ttacaaaaag cgcgcctctt ccttggatgc cgtatgcacc tgctttatcc atcggctctt 2320681 ttgtttcaat atatgtccaa atctcttctt cactgaggga ccaaaacgca acttctgtct 2320741 tatcataaaa agtctcgctg tgattttcag cttgaatgct gaccgcggtt attactgagt 2320801 gacttcggcc tgaaagcctc cgcagcatag aagcagcttc ttcttgatcc tgcggtttgc 2320861 caagacattc gccgtcaagg cataccattg tatcagcacc gataacgatt gcatgcgggt 2320921 ggagatcagc tacagcctta gctttttgtt ttgccaacca ttggacgttt tcttctggtg 2320981 aaaagtttcg atttaatttt tcttctactt cactgacaat aatggagtag ggcagctgga 2321041 gaagatcgag gagttctttc ctgcgcggag attgtgatgc aagtattagc ggttttgtca 2321101 tgttcgtcat cctttcaggg tttgcttaag aaaaaaagat actcgtttat cctaccaaat 2321161 cacgaggctt gtcacaattt cagaaaaata actttttcat gacaaaataa aaaaagcctg 2321221 tcactaaagg acgaaggctc agggcactat ctcttatttt acgacggcta acagctcctg 2321281 ctgagccttc cacccggctt cagcacttgg atcctctaat tcctttaaag cctgcaaaat 2321341 cgcttttttc tctcctgttt ctgacgcttt tgtttcacca agcgactttt ctattttctc 2321401 tacactcgct tttgtaatgt cttcgtcgag aatcgccttt gctgcaagct ccgctgtttc 2321461 cttaaaagaa tctgtcatat ctgactctat tgataaggaa agctccttgc ctccccaggc 2321521 ttcaaaatca ctgtcgatta aaacctgtcc taactgctgt gagacctcct tttcacttgc 2321581 taagcctgca ataacatacg tatacccgtc atcctttgac agtgacacgg cggaatatcc 2321641 tttttcggtc aattgttctg ttaacgtttc ggcgcccttt tcatttgaaa attttccggc 2321701 ttgcacagcg tatgttttgt atgtaccttc agtttgtgcc gcttgttttt ctgcgcctga 2321761 ggtttgttta tcagcagaag tatcccctgc ttttgccgtt tggctgccta aagaatcctc 2321821 taaagaggcc ggtgctgacg cttctttatt ccccgatatg tttaacgcga ataaccctaa 2321881 tccagtgcca atgacagccg cgaaggcaat cgtcgcggcc actcttttta ccggtttggc 2321941 agccccggtc tttccttttg cgtaaagctt tgtttttttc ttttgaaaag gaggaacaac 2322001 tttagggtcc tctttaaaca ccttgtcctc ctcggaatcc caattgaatt catcttcatc 2322061 agggtgttcc tgggatgccg caacctcttg ttctgcctgt cttttttcct cccaatttga 2322121 aaatgtcatg cttttattcg cctctgtctc aggcgtctct tgttcgtaaa ccgtctcttc 2322181 ttttccatta atcgtcacct tgagggcttt ttctgcggct ttactgtttt ttttattctt 2322241 tctttttttc aattccgctt cctcccttca tttgcttgac cgttcttgtc ggcttttcat 2322301 gctacacact ttagcacagg caaagaaaaa aagaacaaga cttttgtcgc cttgtccaaa 2322361 aaacgttcgt caaatttttc agcagtcagc ccaatgccat tttgatataa aaagaaatga 2322421 tagagtcacc gtataaatag gctaaaatgc tccctgcggc tatagcgggg gcgaagggaa 2322481 gcggctgcct tttagcgagt ctaccagtca gaacagctgc cgctccatat aatgcaccta 2322541 tcaaaactga aaagaaaaag gcagctgcca gcattttcac accaagcaca aagccaatca 2322601 ccgcaaataa tttaatatct cctcccccta ctcccccatg ggtgattgcg gcaattacag 2322661 ccagaaacaa aaatccggct gccgcaccta acaggcctgc ataccaggaa tcaagcggag 2322721 aaatcaatct cgcggccgcc aaaaagggaa gaaagaaaat caatattcga tttggaatca 2322781 gcataaaatg aatatctgtc actgcaacaa taatgagaag agagataaac accacagcgg 2322841 gaaacagttc cagcgatatg ccaaagcgta ttcctgcggc ggcaaataaa cacgctgtca 2322901 caagctctgc tgcgggatac ataaaagaaa tcctatgccc gcagctttta catttacctt 2322961 tttgaaatag gaatgacagg atgggaatta attctgcagg agttaatgtt cgccggcaaa 2323021 acgggcatga tgaacggggc gcaataatag atagatgtaa ggggatacgg cacccggccg 2323081 tatagtaaaa agaaccaagg ataagcccga agataaaaag aatggatagc atagacaaca 2323141 cacctttact cattgagttc tggtatggat tgtagcaaaa tggacatcct gagctccaat 2323201 tgggaatatt caattttaca catgaaaaaa acggcagaat ctttttttga ttctgccgga 2323261 gccggatgct tttatttcaa cctttttcga atgtcagaaa taaagtaaag agatccggta 2323321 atcagcacaa tttcatttga gcccttttta ctttctatga atttgattac atcgtctgga 2323381 tcttcactcc agcttttatt gctgatttca cttgcatcat agagatcttt tgcaagggaa 2323441 gcacgcggga aatcaaaaga agcaaaatga atcgcatgag caatggtttc cagtctttta 2323501 atcatgttct gatacggttt gtcctttaac gcgctaaaca ccacagaaat gcgtgaattg 2323561 gcgaaacgct gcttcatcgt ttccgccagc ttttcaacac cttcttcgtt atgcgcaccg 2323621 tctaaatata ccggaggatg ttcctgaaca agctctaacc gtcccggcca agcagccttc 2323681 acaagcccgc tccttaacgc ttcgtcactg atatgggcga tattctcctt attgagccac 2323741 tccgcagcca aaatggacaa agcagcattt tgtctttgat gggtgccaat cagagatgtc 2323801 cgaatatctt catagcattt ctcttccgtt ttgaatgaaa actgttctcc tgcaggcaga 2323861 gcctcttcat tgaaaataac acatgcatca tgcaatgact ggaacggcgc agcatgccgt 2323921 tcggcttcat ggcggatgac ctgtaaagct tccggctggg taactgctgt aacgattgga 2323981 ataccttctt taataatgcc ggccttttct cctgcaattt cttcaatggt gtttcccaaa 2324041 atgttcatat gatcgtgtcc gatgcttgta atcacagtta agagcggttc aaccacatta 2324101 gtagaatcga atctaccgcc cagacctgtt tcaaaaataa caaaatcgac cttatgaaac 2324161 tctgcaaaat ataaaaatgc acaagctgtc ataatttcaa attctgtcgg ctgtccgtat 2324221 tccgtttgat caagggcttc aacgtgcggt ttcatttgat tgacgagtgc tgtccattcc 2324281 tcatctgaaa tcggtatccc gtttacgctg atccgttcat taaacgtaat aatataaggc 2324341 gatgtaaatg ttccaaccgt atatccggct tcctgcagca tagaacggat aaaagcgaca 2324401 gttgatcctt taccgtttgt tcctgcgacg tggaacgctc ggattttttt ttcaggatgt 2324461 cctaaccgcg ccatcagctg tttcattcga ccaagtccgg gcttcacccc gaatttcagc 2324521 ctcccgtgaa tccagctgcg cgcatcttga tatgcagtaa acaatgataa tcccctcttt 2324581 tataagacaa ggcggtttct ctagaaaccg ccccggcttt tcattaaccc ttcagctcag 2324641 ccattcgttt ttgaacagcg tcacgcttcg ccacataatc tttttctttt tcacgttctt 2324701 catcaattac gtgtgcaggc gcttttttca taaatccttc atttccaagt ttcttttgga 2324761 cacgctcaac ttcttttgtc agtttatcaa attctttttg cagacgggca atttcttcat 2324821 caatattgat taagccttca agcggaagaa taacctctgc tcctgagaca acggccgtca 2324881 tcgccttatc aacagcctca atatcggtgc cgattttaag cacgctcgga ttcgtaaagc 2324941 gttcaacata tgaacggttc gcttcgaggc gggacgctat ttcgtctgtg cttgttttaa 2325001 tgtacagttc aacctgcttg ctcattggcg tattgacttc actgcggata ttgcgcacag 2325061 aacggatcag ctcaacaaga agcttcatgt cagctgccgc ttcagtatcg gtatgctccg 2325121 gcactactgc aggccattga cttactgtaa tcgattcccc ttggtgagga aggtgctgcc 2325181 aaatttcctc cgttaagaat ggcataaacg gatggagcag acgcatcgtt tgatcaagta 2325241 cgtaagcaag gatggaacgg gtagttttct tagccgcttc gtcttctcca taaagcggaa 2325301 gcttcgccat ttcaatatac caatcacaga aatcatccca aataaagtta tataaatggc 2325361 gtcctacttc accaaattca tatcggtcag caagctgggt cacgtgctcg atcgtttcat 2325421 ttaatcgcgt taaaatccac ttgtcagcga ctgacttttc acctgacaga tcaagctcat 2325481 cgtacgtcat gccatccata ttcattaatg caaaacggga ggcgttccaa attttattgg 2325541 caaaattcca ggtcgattcc actttttcat agctgaagcg cagatcctgg ccaggagagc 2325601 ttccagtcgc aaggaaataa cgcagagaat cggctccgta cttgtcaatc acatccatcg 2325661 ggtcgacacc gttgccaaga gatttactca ttttccggcc ttgctcgtca cggattaagc 2325721 cgtggattaa aacatctttg aacgggcgct cgcctgtaaa ttcaatgcct tggaaaatca 2325781 tgcgtgatac ccagaagaaa atgatatcgt accctgtcac gagaacatct gtcggatagt 2325841 agcgtttaaa gtcttcagcc gttacatcag gccagcccat tgtggagaaa ggccatagcg 2325901 cagaactgaa ccatgtatcc agtacgtctg tatcctgttc ccaattttcg ctgtcttccg 2325961 gcgcttcaag tccgacatat agctcgcctg tttctttatg ataccaggca ggaatacgat 2326021 ggccccacca caattgacgg gagatacacc agtcgcggat attttccatc cagtgtaaat 2326081 acgttttttc gaaacggtca ggcacaaagt tgaccttttc ttcttttttt tgcagctcaa 2326141 tcgctgcatc agcaagcggc tgcatgcgca caaaccattg tgtagaaaga taaggctcca 2326201 caacagcccc gcttcgttca ctatggccga cagagtgcat atgatcctcg atcttgaaga 2326261 gaactcccgc ctcctgtaaa tctttcacga gctttttgcg gcattcaaaa cgatccatac 2326321 cttgatattg gagcgcattt tcattcatcg tgccatcttc attcatgaca aggatgcgtt 2326381 ctaaattgtg gcggttgcca agctcgaagt cgttcggatc atgagcaggc gtaattttca 2326441 cggcacctga accaaattcc atatcaacat agtcatcacc gacaatcgga atttcacgat 2326501 ttacaatcgg caggatcacc gtttttccga taaggtgttt atagcgctcg tcttcagggt 2326561 gaacggcaac agctgtatca ccgagcattg tttcaggacg tgtcgtcgca atttcaattg 2326621 agcctgaacc gtcagcaagc ggatagctca tatgatagaa tgcgccttga acatccttgt 2326681 aaatcacctc aatgtcggat agggctgttt ttgtcgctgg gtcccagtta ataatatatt 2326741 cgcctctgta gatcaggcct ttttcataaa gcttaacgaa tacttccctt accgctttgc 2326801 tcaagccttc atccagcgta aaacgttcac gggaataatc taggccaaga cctaatttcg 2326861 cccactggct gcgaataaag tcagcatatt cttccttcca cttccacgtt tcttcgagga 2326921 atttttcacg gcctaaatcg tagcgggatt tgccttcttc acgaagtttc gcctccactt 2326981 tagcctgtgt cgcgatgccg gcgtggtcca tgccaggaag ccacagcaca tcatagccct 2327041 gcatgcgttt cattcttgtt acaatgtctt gcagcgttgt gtcccatgcg tggccaaggt 2327101 gaagtctccc tgttacgttt ggcggcggga tgacaacaga gtatggctct tttgtctggt 2327161 cactgcccgc ttcaaaaaat ttgcctttta gccaaaaatc atatcggtct ttttcaaccg 2327221 ctgccggatc atatttcgtc ggcattgttt gttcattcgt ttccatcata accctccagc 2327281 atgtttaaaa atggctgaga acgaaaaaag agctcttcat ccctgtaaaa ggacgaaaag 2327341 ctctttcgcg gtaccacctt ttttcatgaa ctcaatcagt tcatgcactt ataacggata 2327401 acgggtgttt cccgaatttc tctactcttc tttcaagaaa ttatgctccc gggcgacctt 2327461 ccaatcagac aacataagaa gcctttcagc aaacggcttc tctctctgca tgcgcctttt 2327521 ttgtactctt cccgttctaa gcaggtgtat ttatcagctc attgtataca ttatttatgt 2327581 tctttattat agtaaaagtg tttttgattc gtcaatcatc ttttccaaaa acaccgcttt 2327641 ctatacagat gggcaggcac ctattgccca agtttacata tgatgcttgt aaatgcgtag 2327701 aggaggatgc accgtgaaga aacgtttcag ctcttattcg ctgccgccat gggtaaggca 2327761 aattcggctt gtatccgcac aagtgattat tcccattacg atttttcaag gaatcagaac 2327821 cattttcttt ccgacaacct ttgatgtttt gctgctcgca atcctaatct ttttagcttg 2327881 cgcccttcat ttagaatgga tataaacaaa caagtccgcg ccattaagac gtggactcgt 2327941 tttcagcctg aaattttttc tcttgttcaa tctgatgaat tttcatcaca aacggctcta 2328001 tgtttttcat ttgccaataa gcctttaata attgtgtaca ttcctctttt tcatgctgtc 2328061 ttttcccagt ttgataaccg ttcagcacct tgtacatggc tgccggatat gccatatagc 2328121 tgagaaaaag gctgacttcc gcttcacgca aagggaatga tttcgtatat ccataaaacc 2328181 attcgacgca ttccggacaa gctttcggaa agcctctgaa catttttgta taaaagccga 2328241 gcaggtcgtt ttgcggcgga ccgacagatg ctctttcgaa gtttgtaaaa tatccggtcc 2328301 cggcatcatt atacagaaaa tggtgtatag acaggctgcc gtggttcatt acaacccttg 2328361 aaacgtcctt ttcctttgcg gactcatacc agtcctccag ccgttccagc gcaaagttca 2328421 ccgcggaaat ggtttcagaa aaataggtta tggcctggag ttcaaaggga gaaaggtacc 2328481 attccttctc cgctctatcc acaaactgct catagaaaat tttatcttgt tcccactttt 2328541 ttttcgtttg cccgtaataa cgttcaatct catcacgtct aacctttagt tcctgcgcgg 2328601 ttctctcgtg aagacgggct gtttctctaa ataaataagc atgtttttga tcccgttctt 2328661 cctcttggtc aaattggagc caaggcatta aatagtagat atctccgtat tgtatgcctg 2328721 ctgagaaaaa ctcaccgcta tttgttctgt aaacgggaac gaatgaacga aagccttttt 2328781 cctcaatcgc caccatatga tctgtaaaat gcttgccgcg accttctttc aattttttca 2328841 gggcaaatat gccgtagtct gtatacactt tccaaacaag aggactgaca ggctcaataa 2328901 attgagcagt cagtccgtat tcctgaagaa ccgattgggt atcttccatt tcattcacca 2328961 cattttccga tcacttacgg tttacgcatg gctattttta tattgaggaa tatagagaat 2329021 ctgtcctgct tttaattcat catccaaggc taaagaattc atcctgatca gctgctggga 2329081 tgtaatttca taccgttcgc ataaacgctc gatcgtatct tcctgctgca caatacaaat 2329141 tttcattctc gaaaactcat ccgcttcttt tgtaaagagt tttgttaaat aaagagaatt 2329201 atcactttcc tttgtttgag gttccttcgt ttcagcagca ggagcaaccc taggaacagc 2329261 atccgtttcc ttcctttcag tctcagaaga ttcaggcagc tggaaggatt gaaaaggtgt 2329321 ttcttcctta ggctcttcag ctgatggtgt ttttctcact tcaatttcga agctctcttc 2329381 ctcttgttct tcctcctcca gcagcttagg cgctgaataa aaagaatcct cctcttcttg 2329441 ttcaggcagg aaggtacggt atgccggttc aggcaattct tcttgagatg cctcctccga 2329501 gcttgttttt tgattgaaat ggaaatgtaa atcggcattg tcattctcca tatatacagc 2329561 tgaagctgtt tctctgctat cttctatgga gagagcggcc tctgatacac tctccaaagc 2329621 ttcatccggt tccgcctctt cttggcaaag cgcaggatca gcctgatccg attgagctgc 2329681 ttcttcattt tgagcctctt ggcgcagcgc atattcatga ttaggagaca ctgttgtttc 2329741 ctctttttcc tttgcaatca cagtctctga atgaagctca gcttccaaag caggcgattc 2329801 ttctgctcca acgtgttcac gaagctcagt ctccgctgga gagtctgctt cttcacgaac 2329861 atccgctatt gcagctgccg gctctgccgt ttcttttttt gctttaacga tctcttgaat 2329921 ctctatttct gaaggatcag gttctggctc agattcttct gtttccgatt cagcacgaac 2329981 ctccgtttcc ggcacagcaa gctcttctga ctcttcttcc tctttcacat cttctctggc 2330041 ctctggttct gaagcaaccg attcaggcgg ctcagattct gctttttctg tctccagttc 2330101 ttcacggagc cccgctttcg agataaaaag ttctggcggt tcggctggcg gttcatgctg 2330161 aagaactgct tcctctgccg atgatgcacc cggttcttct actacactat gtgccggcgg 2330221 ctctgaaagc tcttcctccc tgaatgccgc aggagcttca tataaaggta tctccggctc 2330281 tttgtcttgc gtatcgtcca aaagcccttc gatcgctaaa tcagcttgaa ttgttaaaat 2330341 gcgcgaatcc gtcaattgat agtcaaatgc gtcaataaag acgaagacat cctgtaaatg 2330401 gctcacttta tttttcggaa tggtaatatc cacaggaaaa cagtgagtca gttccgcact 2330461 tccatcctct ctctttctga cttgttcaac aaaccgctta tctgtataaa tctcttcggt 2330521 atgtttgttt tgatctatgt tgtactcacc tgtaagttca agcgatccta tgattgatac 2330581 ataatcattt acttcctgaa ccctaatatc aggatctaat gaaatagaaa gcagttcaga 2330641 aacttcctgt cctttttgga aacagatcga ttcttctaca gaaaattgca atcgatgatt 2330701 ttgcggcaag ttcatatcct cctttcatct aatccttaaa attagatgtc actaaaggtg 2330761 tatgtatgaa ctggagaaaa tatgagtggg agagcacgaa aaaaccggca caaggagtcc 2330821 ttgataccgg ttttcactct tatctgcggc tgatctcagc aaatactttc tcagctgcct 2330881 ggattgtgtt ttcaatatct tcatcagtat gggccgttga gaggaaaaga ccttcgaatt 2330941 gtgatggcgg aaggaatacc ccttcatttg ccatcccttt ataatagctt gcgaacagct 2331001 tcaaatcaga tgatttcgct gtttcataat tgatgactgg ttcgtttgta aagaagaaac 2331061 cgatcatcga acctgcacgg ttaaaggtat gcggaatgcc atgagccccg gcggtttttg 2331121 aaattccttc ttccagtctg tcgccttttt tgatgaaatt cttgtaggat tcaggtgtca 2331181 gctgtttcaa tgtctctaag ccagccgtca tcgcaagcgg gttgcctgac aatgtaccag 2331241 cttgatagat cggaccgctt ggagcgatct gctccatgat ttctgccttt ccgccataag 2331301 cgccgacagg aagtccgccc ccgattactt ttcctaaaca agtcagatca ggcgttacgc 2331361 cgaagtagcc ttgagcgcag ttataatcga cccggaagcc agtcatcact tcatcaaaaa 2331421 tcagcaggga gccgtactgc tcagtgatat cacgcagacc ctgaaggaaa ccttcttgcg 2331481 gcggaacaac acccatattt ccggcaactg gctctacaat gactcccgca atgtcttcac 2331541 cgaattgctg gaaagcaagc tttacacttt ctaaatcatt gtacggaacg gtgatggtgt 2331601 ttttcgcaat gccttcaggc acccccgggc tgtcaggcag accgagagtg gcaacacctg 2331661 aaccagcttt aatcaagaga gaatcgccgt gtccgtggta gcagccctca aattttaaaa 2331721 tcttgttgcg gcccgtatag ccccttgcca aacggagggc actcattgta gcctctgttc 2331781 cggagcttac cattcgtaca atttctacag atggcacacg atcaatgacg agcttagcca 2331841 gttcattttc tacttcagtc ggagcaccaa agcttgtccc gtattcagcc acttttttga 2331901 ggctttctac gacgcggtca tttgtatgcc ctaaaattaa aggcccccat gacaagacgt 2331961 agtcaatata ttcattcccg tcaatatcaa agattttcga gccttttccg cgctccataa 2332021 aaatcgggtc catgtctacc gatttaaatg cgcgaacggg actgttcaca ccgcccggca 2332081 tgagtttttg cgcttcttta aaagccgttt ttgatttttc atagcttctc atctgcctca 2332141 actcctgtca actgaataaa attactccgc aagccatttc gctgcgtctt tcgcatgata 2332201 cgtaataatc aggtcggcac ccgcgcgctt catgcttgtc aaaatttcca acacaatttc 2332261 tttttctttg atccagccgt tctgcgctgc agccttcacc attgaatact ctccgcttac 2332321 attataagcg acgagcggca aagtaaactc attttttacg tcacgcatga tatccatata 2332381 agaaagcgaa ggtttgacaa tcaaaaagtc cgcgccttcc tcaacatctg attgtgcttc 2332441 gcggagtgcc tccatacggt tggcagggtc catctgatat gttttgcggt ctccgaattg 2332501 cggtgtgctg tttgctgcat cacggaacgg accgtaaaac tcacttgaat atttaacagc 2332561 gtaagacatg atgggaatat tgacgaatcc ttctttatca agtgcttctc tgatcactgt 2332621 aacaaatccg tccatcatgt ttgatggcgc aatgatatcc gcacctgctt tcgcttggct 2332681 gacagctgtc tgcgccaaaa gctccagcga ttcatcattg agaatgactc cgtctttgac 2332741 aagtccgcaa tggccgtggt ctgtatattc gcacaggcac gtgtcagcga caacaaccat 2332801 ttcagggaag tgttctttaa tttctgtgat ggctttttgg acaattccgt gatcatggta 2332861 cgcttgtgtt ccgcaatcat ctttttcttc cgggatgccg aacacgataa cagattgaat 2332921 gcccagtttg accagctccg ctacttcatc cttcaataaa tctaatgata catggtgaac 2332981 atcaggcatt gacggaacag cttttttgcc ttccagccct tcaacgacaa aaatcggata 2333041 tataaaatct gatggatgca aacgtgtttc ctttaccatt tctctcattg cttttgatgt 2333101 ccgcaggcgg cggtgtctat taaatgattg actcatattc tctcttcctc tcttgacatg 2333161 ctgcacatta actcaagcat gccatctatt gtaaatgtat caggcgtatg cgatgtgatg 2333221 ccgtacgtca gaagggcatc atttgttaaa ggcccaatgc tgatacaggc cgtcccattc 2333281 gccttccact tttttaattc ttctcccaag acatgcataa acgtatgtac ggttgatgaa 2333341 ctcgtaaatg ttacatagtc aaaggaatat tgacccgcag cgtctttcaa tgcctcaatg 2333401 ccttcttcat ccggaatcgt ttcgtagaga acccattcct ttacttcaaa accgagcggg 2333461 acaagctctt gttttatcac atcacgtgac aaattccctt tcatcacggt aatggtctcc 2333521 cccggttcag catgctgctt aagagcgtca gccaattgtt cagcaatata ctcctgtggc 2333581 atcacatcaa ccgatacgtt atgcattttt aaacggcgcg cggttttttc accgacggct 2333641 gcaatttttt tatgcgcagg gagaataagc tgattttcct tcagataaga aaaaaagaag 2333701 tctgccccgt tcacacttgt aaaaacaagc cagcctggcg cggcaagatc ctctcttacc 2333761 tgttccgcaa catcattcgg caaagcgcgg cgaaacgtaa tcaaagaggt taaaaccgct 2333821 ttaccgccaa gcgcctccac tttttgctga aatgatgctg cctgtgcctt attccgggtg 2333881 acaagcactg tttttccttt caacggaaaa tcattttcca tcctcgtcaa gctcccgttt 2333941 tacacgatca attaaatctt ttgctccttt gtcagccata agagcggcac agcgctttcc 2334001 tacttcctcc ggatcgtttc cggtgacggt ttctttaaaa atgattttgc cgtcaggtga 2334061 agcgacaaga cctgtcattt caatttcatc ctgtccattt aacacggagt agcccgcgat 2334121 cggaacctgg cagccgccct ccatcgcgtt taaaaaagca cgttccgcta agacagtccg 2334181 ttttgtatat tcatctgtaa actgagaaaa caacgccaac agctcttcat ccgattctcg 2334241 gcactcaatc gccagggctc cctgccccac agcaggcaaa cagcgctcag gctcaaggaa 2334301 ttcggttacg acatcttgct tccaacccat tctggaaagg ccggcagccg ctaaaataat 2334361 tgcgtcataa tcctctgttt ccagcttttg aagtcttgta tctatattac ctctaatcca 2334421 tttaattgta aggtcagggc gctcaatcaa aagctgcgcg cttcttctta aactgcttgt 2334481 gccaatgaca gcacctttct tcatttctga aagctttacg cgattctttg aaataagggc 2334541 atcacgcggg tcctcccgtt caggaataca gccgatcaca aggccttcag gcaaaacagc 2334601 aggcatgtcc ttcatgctgt gcactgccat atcaatctct tcgtttaaaa gcgcctgttc 2334661 aatttctttg acaaaaagcc cttttccacc cacttttgag agtgtaacat cgacaatccg 2334721 gtcgcccttt gtcacgatct ctttaatttc aaaagcaaac gaaggattga tttccttcag 2334781 tttttgaata acccattttg tttgagtcat agcgagtttg ctccgtctgg aacctacttt 2334841 aatcgttctc atcatttctt tcctcccgaa tctgcttggg acatcgttta actgaaccaa 2334901 tggaattgcg acaggcttcc aagcaggaaa taattgatca tcagcaccag aaaacaagcc 2334961 gtattccaca gtgcagcgac ctttccttgc agctccttaa tcagcctgat ataaagataa 2335021 tagctgtaca gcagcaggac gacaaacgaa ccaagcactt tggcgtcaaa ccaatacagc 2335081 gtttctagtg agacatacgc ccaaatgacg ccgagaatca aactcagcag cagcatcgga 2335141 accccaatga catttaaaac atacgccata taatcaagct tagataaatc ttctattctc 2335201 aacagccatt ttccccactt tttctttttc agcagatgat attgaaacat atatagcaca 2335261 gaaaaaacga aagaaaggga aaaagcgccg tatgaaagaa tcgccattgt aatatgaatc 2335321 accaaaagct cggatacaag ctgcccggaa aaagcagctg actgctgctc tgtcggtgaa 2335381 aatgtgtgaa tggcgatcat agaaaatcct ataacatttg taaaaaacac gataaagtca 2335441 acacgtaaaa gctttgtcag tacaagtgac agcgtgacaa gcacccaggc ataaaaataa 2335501 agtgcctctg tcacatttaa taccggaaac cgccccgtca cccacataaa ataggccaaa 2335561 tacacggttt gcagagtcca gacaatagaa agcaaccaga aggccatttt tccagccttc 2335621 cggttgtgtt gaagaaaatc tataaaataa aagagtacac ttaacgcgta aatgacgatt 2335681 gtcccctcat taagtcttgc cattgcagta tcaatcattc agctttcact cacttacaag 2335741 tgggctaaag cccgcttttg attcagcctt cttaaaagag tggaccttct ggctgctttc 2335801 aacggttttc atcatttgac ggcccgcagc ttcttcaata tcaaaaatct gcataaacaa 2335861 cgcgagcttt tcttcagaat cagcatctgc cgcaagctct ttcaccttta aaatcggatc 2335921 acgaagcatt tggttaataa tacttttggt gtgtttgttc aacagttttt tctctcttgt 2335981 gcttaagtga ggcagcttac gctcaatgct gtccatcgtt tctgactgga tggcaagcgc 2336041 cttttcgcgc aatgcagaaa taacaggcac aacaccaagt gtattcatcc attgtttaaa 2336101 ttccacaatg gtttcttcaa ttaacagttc aactttttca gctgtttctc tccgctcttt 2336161 catgttcgct tctacaatgc cttccagatc gtcgatatca taaagaaaaa caccttcaag 2336221 atcattcagc gccggatcaa gatctctagg cacggcaatg tcgaccataa acagcggacg 2336281 tcccttgcga agcttattcg cgttttccat catctctttg gacacgacaa attcacttgc 2336341 accggttgaa ctgattaaaa tatcagcctc cgcaagcgcg ctttcaagct gattcaagct 2336401 tctcgcttca cctgaaaaac ggtctgcaag ctccttcgct ttcaagtatg ttcggttaat 2336461 gacagtgacc ttgccgattc cctgtccgtg caggttttcc gcagcaagct cgcccatttt 2336521 tcccgcaccg agaatcaata tgtgcttgct tgaaagattt ccgaagattt ttttggcaag 2336581 ttcaactgca gcatagctta ctgacaccgc atttgagcca atgtctgttt cggcgtgagt 2336641 ccgtttgccc actgtaactg cctgcttaaa cagctcatta aaaatagtcc cgatcgtttt 2336701 ttcttgctga gctgttttaa agctgtcgcg tacctgtccg agaatctgcg tttcgccaat 2336761 caccatagaa tcaagtccgc aggctacacg gaataaatgc tcaacagcgg catcgctctc 2336821 ataaaacgtt aagaacggtg acagctcttc tttgcttaat tgaaaccaat cagctaaaaa 2336881 cttttttata taataacggc cggtatgaag ctggtcgact accgcataaa tttcagtgcg 2336941 gttgcaggtt gagacaatga tgttttcaag aatgcttttc tcttctttca gctgcaccat 2337001 tgcttctgcc agctcattcg gctgaaaact tactttttca cgtatctcaa taggggcgga 2337061 tttataatct actcccacaa caagtatatg catcgctcta attacacccc caacacccaa 2337121 tcttaattta taatcattct aacatagaac tcattattta taataattat aacatagttt 2337181 ctttcacaaa atgtgaacag attttaaaat tcttatgcta tattagaaaa agcttcaggg 2337241 aaaagaagca ttcctattga caataccaaa aacagcagaa atttactaca catcagctct 2337301 aaaaaacaag aaggtgatat gcatgaaaca aaaatcaatt ttattccctt gtctgctgct 2337361 tgccgcttct gtatatgcat ggctagaaag cggccaagcc gaactgtttt cagggcagga 2337421 tcaatggcct gttctcctca tgctgttagg cgcagccttt gtatatcaag gaaaaaaaga 2337481 agccgtcaca ccccattttt ttatcggttt gcttctcttc gggatcggtt tacacttttt 2337541 tgccaagccg aaatgggtat ggtggccgga tgattttgaa atgctcctct ttatgatcgg 2337601 cttctcactt ctcgtttcaa ccgttcaaaa aaaagaatat gtatatgaag ctgtgtcgat 2337661 gatttgtttt tccctgtttt tgtacttttt caaacaaatt atggcatggc ttgagtctgc 2337721 gcatattcca acagcgcttc tgaaggagta ttggccgttt gtctttattg gaatcagttt 2337781 attgttatta ttgataaaac gaaaaaaatc tatacgataa ataaaaccgg tagaggatcc 2337841 tctaccggtt tatcattttt ttgatcgctc cccaagcttc gtcttttccc tttttcgttt 2337901 ctgaagaaaa gaggatcagc tcgtcttccg gatcaatatt taatgtttgt cggacaacct 2337961 tcgcgtgttt gtcccattta cctttcggga tcttatccgc ctttgtagcg ataacaataa 2338021 caggaatgcc gtaatacttt aaaaattcat acatctgtac atcatcatta gatggcgcat 2338081 gccgcaaatc aacgatctgc accacagctt ttaattcctc gcgtgtcgtg atataggttt 2338141 caatcattct gccccatgct tcacgctcag actttgacac tttggcaaaa ccgtagcccg 2338201 gcacatccac aaaatgcagc tcatcattga taatgtagaa attaagcgtt tgtgtttttc 2338261 ccggctttga tgacgttctc gcaagatttt tgcgattgat taatgaattg ataaaagacg 2338321 attttcctac gttcgatctt ccggccaatg cgatttccgg aagcccccct tcagggtact 2338381 gttccggttt tactgcactg atcacgattt ctgactttgt gactttcatt tcttctctcc 2338441 tactaaggca tgttccaaaa cctcgtctaa gtgggacgcc aatataaatg tcagcccctc 2338501 cctgacgctt tccggaatat cctctatatc tttttcatta tctttaggcg caataatggt 2338561 cgttaatccc gctctatgtg cgccaagcgc tttttccttt aagccgccga tcggcagcac 2338621 gcgcccgcga agcgtgattt ccccagtcat gccgacttca cgcgaaaccg cccgtcccgt 2338681 taaagcagaa acaagcgctg ttgccatcgt aataccggct gacggaccat cttttggcac 2338741 cgcaccctct ggtacatgta tatgaatatc atacttctca tgaaagtcag gttcaatgcc 2338801 aagttcttct gttttggatc gcacatagct gaatgcagcc tgagcagact ctctcataac 2338861 atctccgagc tttcctgtca ggattaattt cccttttccc ggtgaaagcg atacttcaat 2338921 cgaaagcgta tctccgccaa cggttgtata cgcaagccct gtcactacac caacttgatc 2338981 ctctgtttca gcttgtccat atctgaaaat gcgttttccg ataaaatctt gaaggttctt 2339041 ctcagtaacc gtaattcgtt ttcgctcttc agcaacaatg gcttttgcag ctttacggca 2339101 aattgcggca agctggcgtt caaggcttct tacacccgct tctctcgtat agtaacgaat 2339161 aatatcaaga atcgcctgat cacgcagctg aagattgctt ttcttcagcc cgtgttcttt 2339221 gatttgcttt ggaagcaagt gatcctttac aatttcaagt ttttctattt ctgtgtagcc 2339281 tgcgatatta ataatttcca ttctgtctct gagcgggccc gggattgtgg ccaaattgtt 2339341 cgccgttgcg ataaacagca ctttggataa atcaaaggtt tcttcaatat agtgatcact 2339401 gaagctgctg ttttgctctg gatcaagcac ttcaagcata gcggatgatg ggtctcctct 2339461 aaaatcagat gacattttgt caatttcgtc taataagaag accggattca gcttgcccgc 2339521 ttttttcatc ccttgaataa tacgtccagg cattgctccg acataggtcc gtctgtgtcc 2339581 gcgtatctct gattcatccc gaactcctcc gagtgagatt ctgacgaatt tgcgtcccaa 2339641 gctttttgca attgatttgg ctaaagacgt ttttccgaca cctggaggtc ctgccaaaca 2339701 gagaatcggg cctttcaggg attttgtcag cttctggaca gccaaatatt ctaaaatacg 2339761 ttcttttact ttttcaagcc cgtggtgctc ttcgtccaag agacgtcctg cttctttcaa 2339821 atcaagctta tcatctgttt catccgtcca cggaagagca accagccagt cgatatagtt 2339881 gcggatcaca gagctttccg cagaacttga cggaattttt tcatatctgt tcaattcttt 2339941 aagcgctgtt tctttcacat gatcaggcat gcctgcttct tcgatttttt ccgtcagcgt 2340001 ctgaacttcg ccagttttgc cttctttatc gccaagctct ttttggatcg ccttcatttg 2340061 ttcacgcaag tagtattcct tctgcgtacg ctccatcgaa cgtttgacgc gctggccgat 2340121 ttttttctca atctccagca cttctttttc attattaata aaatcaatga ccttgttcag 2340181 cctgtctttg acatcagccg tttctaaaat atcctgctta tcctttagtt taaggggcag 2340241 atgagaagca acgatgtctg ccattctccc cggctcttcg atatcagtaa ccgcagcgta 2340301 cgtttcggcc gagatttttt tagaaatttt tatgtactga tcaaagtggt ctagcaaagt 2340361 ccgcatcaat gcttcgtctt ctgtatcttt tgaatcatct tcatgaataa gttgaatgtc 2340421 aaccgacgtg taatcctcgt gttcattgta tttgacgata tgggcgcgct tgaggccctc 2340481 caccaacaca cgaatcgtac cgttcggaag cttcagcatt tgcttaattt ttgtataggt 2340541 gccgacagtg aaaatctcgt cttcaccagg ttcgtctatc gaaatatcct gctgagtggc 2340601 taaaaatatc atatgatcat gcatcattgc ctgttcaaga gcctgaaccg acttgtcacg 2340661 tcctacatct aaatgcaaaa ccatcgtcgg gtacactaat aaacctctta aagggaggag 2340721 cgggatgctg cgttttaatt cttctgccat gtgactgaca cctccgtgac tttagtatga 2340781 accattataa tacaactttt tcatccttgt acaataaacg gcatggttcc attttctata 2340841 aaacagtctc ctcgtagtat accctttctt tctgatatga aaaaggaaaa gatgtccttc 2340901 atgaaaaaaa ccctattatc aaaatagggt ttaaacggat tctttattga tttcgatatg 2340961 aaacggtttt tgttccgttg gcggattcac caaaatttca tcaagcactt cttggaacgt 2341021 cttcactgca ataatctcga tcccgtcaat ctgctttaag atggcctgct gattttcata 2341081 tgggataatc acctttttcg caccggactg cttggccgct tttattttcg gaatgacgcc 2341141 tccgatgggt ttcacaagac cgttcaggct gatttcgccc gtcatcgcaa cggtattgtc 2341201 aataggaatt ttgtgtatcg ccgagaaaat ccccgccgcc atcgcaatgc ctgctgacgg 2341261 cccatcaatc ggaatccctc ctgggaaatt gatgtgaata tcataatcag aaggcttcat 2341321 tcccattgtc cggagcacgg ttaatacatt ttcaaccgaa cccttcgcca tgctttttcg 2341381 cctgatcgat tttgattggc tgccgatgct ttcttcttca gctattcctg tgatgttaat 2341441 tgatccttta tcttgagccg cggttacact tacttcgatt tccagaagcg atccgctgtt 2341501 aggcccatag actgcaagcc catttacaat gccaacctgt ggttcaacac cgattttttg 2341561 ctcgtgcttt ggagtaagct gactggagtg aatgacccat tcaatatcct caatcgtaat 2341621 gtcctttcga ttctccgtta cagccatccc cgctgcgatt tgaatcatat tgacggcttc 2341681 ccgcccgttc cgcgtgtagc tggtcaaaag atccagtcct tcttcggaga tatttttttc 2341741 aattttatcc gctgctgttt tggcaaccgt tttcagctcg tccttttcaa gctcgcggaa 2341801 aaaaacctcc aaacagcggg accggatagc tggcggaatt tcgtttggca ttctcgtggt 2341861 cgcgccaatc aagcgaaaat cagccggcag cccattttga aaaatatcat gaatatgatt 2341921 cggaatttgt gtattttcct cactgtaata cgcactgtct aaaaagactt ttctgtcctc 2341981 aagcaccttc agcattttat tcatttgaat aggatgcagc tcccctattt catcaataaa 2342041 cagcacaccg ccatgggcat gggtgacagc tccctgcttc ggctgcggaa tcccagcctg 2342101 tcccatcgct ccggcccctt ggtatatcgg gtcatggaca gagccgatga gcggatcggc 2342161 aattcctctt tcatcaaaac gggctgttgt cgcatcgagt tccacaaaga cagcctgctc 2342221 tttaaacggt gattgtttat gtttttttgc ttcttccaac acaagccgcg cagcagccgt 2342281 tttcccaact cccggtggcc catagacaat cacatgctga ggatttggcc cgcataaagc 2342341 cgcctttaat gctttaatgc cgtcttcctg tccgacgata tctttaaagc ttttggggcg 2342401 gaccttctca gataatggct cggacaagct gatagcgcgc attttccgaa gctgctccat 2342461 ttccttcttt gattctttat ctatcgtgac cttttgtgtc ctttgatttt taagcaaatt 2342521 ccaaaaatac aaaccgatga tgatcccaaa aaacagctga ataaataacg cgatccctgt 2342581 ccaactcatg gtggtccctc ctgaaaaaca atttatgtat ccaattcatt cctctgattg 2342641 ctagtatctc ccatagaaga cgggaataaa cgtttttccg gaagagttgc atgcaaaaaa 2342701 acctcctgag tgttaccact caggaggttt gtgcttatct ttatgcagat gttttatctt 2342761 ggcttacctc agtgccgtct tttaataaga ggcgaggagg ctctccgtgt gtcacagttg 2342821 ccccggtgat tacacatttt tcaatgtcat cacgagaagg cagctcaaac atcacatcaa 2342881 gcatgatgcc ttcaatgata gaacggagtc cgcgtgctcc agtcttgcgt tcaattgctt 2342941 ttttagcaat ttcagaaagc gcttcttctt caaactcaag ctcaacgttg tcaagctcaa 2343001 gcattttctt gaattgctta acaagagcgt ttttcggttt tgttaagatc gcaaccaatg 2343061 cttcttcgtc aagcttttca aggcttgcaa taaccggaag acgtccgata aattcaggaa 2343121 ttaacccgaa acggagcaaa tcttctggaa gcacttttga aagaagatct tctttctcaa 2343181 gatcagcagc tttattgtcg gcaccgaatc caatcacttt ttggcctaaa cggcgtttga 2343241 tgatttgttc gataccatcg aaagctccgc cgcaaatgaa caaaatattt gttgtgtcaa 2343301 tttgaatgaa ttcttgatga ggatgcttac gtccaccttg aggcggtacg cttgccactg 2343361 taccctcaag aattttaagc aatgcctgct gtacaccctc acctgacaca tcacgtgtga 2343421 tagacgggtt ttcagatttt ctagccactt tatcgatttc atcaatatag ataatgcctt 2343481 tttcggcttt ttccacatca taatcagcag cttggatgag cttcaagaga atattctcta 2343541 catcttcacc cacgtatcca gcttcagtca aagatgtagc gtccgcaatc gcaaacggca 2343601 catttaaaat gcgagccaat gtttgcgcca gaagggtttt accgcttccc gtagggccga 2343661 ttaatgaaat attacttttt gaaagctcaa catcatcaac tttgctgttg gagttaatgc 2343721 gcttatagtg gttatacaca gcaacagcaa gtgatttctt cgcttgatct tggccgatga 2343781 catattcatt caaaatttcg cgaatttcct gaggctttgg tacgtcttta aattctactt 2343841 cttcttctgt tccgagttct tcctctacaa tttcagtgca gagttcgata cattcgtcac 2343901 atatatatac accaggtcca gctacaagct tacgaacctg atcttgtgtt tttccacaga 2343961 acgagcattt taattgtcct ttttcctcgt taaatttaaa cattctttca ccccttaatc 2344021 ttgtctcact ttttctttta ccggcagagc aaaagaaaat gattcttgaa acgaacgagt 2344081 atgtattgca ttttaccata ctttccaaaa agacggtaac aatgtgtttc tgacttgcac 2344141 attctatatg tatgacaaaa aacagccctg cattaactat attgccccaa gaaaaagaga 2344201 taactcataa ttgtacaaaa caaggcacga atgattcgcg ccctgtttta ttagtactat 2344261 tattatgcac catattaacg gttttctaca agaaaatcaa ttgctttgcg aacttttaaa 2344321 tcttctttca tcgcgtcagt agaaccgatg gcttgtttaa tattttcaac aggcatgttg 2344381 tatgcttcag ccatttttgt aagctcagca tcaacttcct catctgatac ttcaaggttt 2344441 tccgctttcg caatcgcctc aagagtcagg ttagatttta cgcgtttttc agcatcttct 2344501 ttcatttgct ctttaagcgc agcttcatct tggcctgaga attgagtgta aagctcaagg 2344561 ttcatgcctt gcatttgcag acgctgttcg aattctttca gcatgcggtc aagctcagtg 2344621 tcgaccattg cttgaggcac atcgatttca gcattttcag aagctttcag aacaagctct 2344681 tcacgcaatt tagcgtcagc ttcgttttct tttgcttctt ctaaacgttt ctttgttttt 2344741 tcagttaatt cagcaagtgt ttccacttct tcatcgatat cttttgcgaa ttcatcgtca 2344801 agctcaggaa gctctttcgc tttgatttcg tgaattttca ctttaaacac agctggtttg 2344861 cctgcaagat cttcagcgtg gtactcctca gggaatgtca cttcaacatc cttctcagca 2344921 cctgcttcaa ggccaactaa ttgatcttcg aagccaggga tgaatgaacc agaacctact 2344981 tctagagagt agttttcagc ttttccgcct tcgaaagctt cgccgtcaac gaatccttcg 2345041 aaatcaagaa caactgtgtt tccttcttca acggcgcctt cttcttttac aacaagctca 2345101 gcttgacgct cttgaagggc ttttagttcg ttttgaacat cttcgtcagt tacagttgtg 2345161 tcgtcttttt caatgcccag gcctttgtat tcgccaagct tcacttcagg ttttactgtt 2345221 actttcgcag tgaagattaa gctttcgcct ttttcgattt tttcaacatc gatttcagga 2345281 cggtctacag gctcgattcc agcttcttca accgctttag ggtattctac aggaagaaga 2345341 atatccaaag catcttggta aagagcttct acgccaaagc gctgttcgaa taatccgcga 2345401 ggaattttac ctttacggaa tccaggaatt gaaacttgtt ttactacttt tttaaatgca 2345461 tcatcaagtg ctgttttaaa cgtttcagca tcaacttcaa ccgttaaaac gccttcgttg 2345521 ccttcttgtt tttcccattt tacagacatg tgtttccctc caaaaatcta ttcaggttgt 2345581 gtcggtcttc cattctaaag caatcattcg gcttcgtcca acaaaaacaa agctgccaaa 2345641 gatcagaatc attatgtata gatgttaata atgaactgca aagcctgtcc aaccgtattt 2345701 cttataaccc gttatacaca aatacaacca ctatattata acataacaca tagcgctttc 2345761 aactatatgg cgcgatttac aaataagaaa tttcttcaat atcttttaac attgtgcaag 2345821 cttcatcgag ttctctgtct gtaaattcat acatcatatg aagttcttcg ctttcaattt 2345881 caatcccgtg catctcgtaa ccgactttat gaagggcagc cgcccaaagg tcagccgaca 2345941 gcaatttcgg ctggaacgga tataaaacgt acaaatgtct tctccacaat tcttctactg 2346001 ctgcatataa ggttggattt tcatttccaa gtgtctcatc tagcaccctg agaacacggt 2346061 gaagaatcgg cgcggcatca ggcggaacaa tctctgacgg ttcaattgtc aacgactcgc 2346121 caaatttact aatgtgtaca ggtttactgt actcatgctc agccaacagc atgacaatca 2346181 tcgttttgat aatcggatgg gctgaggggt cttggaggat tgttttgagc aatcctgtat 2346241 actttgctac gttacggtct tttaaggaat gaatgagatt catttgctcc tcagggcttg 2346301 ccagcacttt ctcggtgtca attgtatcct catattcttc ggcccaagcc tcgtcctcac 2346361 gatccggatc ggtcattttc cggctgaaat ccagcagctt ataaaattgc tcggcacttt 2346421 ctgccggcag ctgattttct tccaaaacgg cttcaatggt gcttttgact tcttcgtact 2346481 ttttgagctg aattaagatg gtcatgtaca cctgcaaaac cgtaaaataa tggccataac 2346541 cttctttgag catcttctcg cacacgcttt ctgcctcttc cagctcgccc agctctaaaa 2346601 agcagatggc catccctaag tgaagatcgg attcagtatc atcatatttc atcgcttctg 2346661 aaaacagttc aagcgcttct tgatactttt tttccttgag tgatgacatc cctttttcca 2346721 caaggcggtc tttcagatga ggaaaaggaa taatttttgc gtttttcttg tcatgcgtca 2346781 tacctatatt cctttcaggc atttattttg ttcaagtgta tcaacacctg tgaacaaaaa 2346841 caagaaatga aaggtttcac caggcaaaaa aagccgccgg acaaataccg gccgcttttt 2346901 caggcttgaa gccaagagct tctttgtgat tcaaattgct tgatttcatc ttccagcagc 2346961 agcgttaatg aaatttcatc atatccgttg atcagcatct ctttccaatg cggatcaact 2347021 tcaaatgaaa tttgattgcc ttcactgtca tgaatcagct gattttcaag gtcaacagtc 2347081 atttgcaatg actggttttc atactggccg acaagctgtt tccaattgtc atatggcatg 2347141 cggatcggaa gcatgccgtt tttaaagcag ttctgatgga aaatatcagc gaatgacggc 2347201 gcaatgataa ttttaaaccc ataatcatca agtgcccacg gagcgtgttc acgcgatgac 2347261 ccgcagccga agttttctcc tgctattaaa atggaagctc cttgataaac aggctggttt 2347321 aattcaaatt cagggttcgg ttcaccattc gcatcatatc tccagtcaaa gaatgcaaaa 2347381 cgtccgtagc ctgttctttc aatcctcttc aaaaattgct taggaataat ctggtctgta 2347441 tccacattga tccgatttaa tacggctgct ttccccgtat gtgatttcaa aggttccatc 2347501 tcgcgcactc cttacacaac tgttttttcc tgataaaact ttctgacatc aacgaagtgt 2347561 ccgtgaatgg cagccatcgc agccattgcc gggctgacga gatgtgttct tgcacctttt 2347621 ccttgtctgc cctcgaagtt gcggttagag gttgatgcac agcgctctcc ctcaggaaca 2347681 acatcattat tcatactcaa acacatgctg cagcctgact ctctccattc aaatccagct 2347741 tccaagaaaa tctggtcaag cccttctttt tcagcctgaa gcttcacgct ttgggatccg 2347801 ggcacgacga tggcccttac gctgtcagct accttcttcc ctttgatcat gtcagcagcc 2347861 tgtcgaaggt cagtcatgcg ggaatttgtg caggaaccga taaatacgtg ctccacttta 2347921 atgtcttcaa ttttttggtg aggagtcaat cccatatatt cataagcacg aatcgcttct 2347981 tttttatcgt cttctgcaga aaagctttcc ggcgcaggaa cttcagaatc gacaggaaga 2348041 accattcccg ggttaatgcc ccatgtcacc ataggggaaa ttttgttgcc gtcaaggacg 2348101 atagatttat cgtaaacagc gcccgggtct gtgcgcagcg ccttccattc ctctacggcc 2348161 ttgtcaaatt cttcgccttt tggcgtgtac ttgcgatttt tgcaatattc aaacgtcacc 2348221 tcgtcaggtg caatcaaacc tgctcttgct cctgcttcaa ttgacatgtt acaaacagtc 2348281 attcgttcat ccatcgtcat atttctgaat acttccccag tgtattcaat gacgtagcct 2348341 gtgccgaatt tcacaccgta tttgccgatg acagcaagga tgacatcctt tgccgttacc 2348401 cctttttgaa gcgttccatc tacgcgcact tcaagtgttt ttggacgctg ctgccaaagt 2348461 gtctgtgtgg aaaggacatg ttcaacttca ctcgtcccga ttccaaatgc aagagcgccg 2348521 aaagcgccat gtgttgatgt atgactgtca ccgcacacaa tcgttttccc tggaagcgtt 2348581 aagcctagtt caggtccgac gacatggaca atcccttgat ccacactgtg aagatcggca 2348641 aggcgcacgc caaattcctc acagtttctt tcaagcgccg ttacctggcg tttcgcaact 2348701 tcatccttta tctcaaaacg attgacagtc gggatgttgt ggtccattgt cgcaaatgtg 2348761 ttttggggtc ttctgacctt tcttcccttt tgtctcaagc cttcaaatgc ctgaggagac 2348821 gtcacctcat gaatgaggtg caaatcaata tagagaagat ccggctttcc ctcaccatgt 2348881 tttacaatat gctgatccca aatcttttcg atgattgttc gaggcatcat cttttatttc 2348941 ctccctctac ctagagctaa gaccgcttaa cgtaagctgt cacacattag aaattgtatt 2349001 ttcactcatg attgctgcct taacttcctc tgtaatggcc tgagtgctgc tgaactcttc 2349061 actccgtgcc aagtctcttg ttctttttcc agaagccaag actttgttta ccgcatcttc 2349121 tacagctttc gcttcctctt caagcccgaa agatgttctc aaaagcattg ccgctgacaa 2349181 tatggctgcg aacggatttg ccatcccttt accggcaata tcaggcgcgg agccatgaac 2349241 aggttcaaac agatgaaggc cagagcttga taggctggct gacgggagca ttccgagcga 2349301 gcctgtaagc atggacgctt catcgcttaa aatatcaccg aacatatttt cagtcaccac 2349361 gacatcaaat tgattcggtg cataaattag ctgcatggcc gcgttatcca caagcatgtg 2349421 ctcaagcttc acatcaggaa attcttgtgc aacgtcctca gccacttcac gccacagccg 2349481 gcttgattca agaacattcg ctttatctac agaggtcact ttgccttttc tggctgccgc 2349541 cattttgaag ccctctctga tcactcgttc aatttccgtt cgcttataaa acagtgtatc 2349601 tactgcttcc tgctcacctt cagtgtttac ataacgtttg ctcggctggc cgaaatacaa 2349661 gccgcctgtg agctcacgaa cgataacgaa atcaacatta tctatatatt cttttttcaa 2349721 aggcgaagcg tcagaaaggc tttcaaatac cttcacaggc cgcaaattcg caaacaaatc 2349781 aagctgtttt ctgatgctga gcagcccttt ttccggtctc agttccgaag gattttgatc 2349841 ccatttcggt ccgccgacag caccaagcaa tatcgcgtct gcatttttac aagcagcaac 2349901 ggtttcctcc gggagggggt tatgatgttc atcaatagcc gcccctccaa tcaggccata 2349961 ttcaaattca aattcatggt taaagcgttc ggcaacactt ttcagtacgt ctgtcgctga 2350021 ttctaatact tcagggccga tcccgtctcc gggcaataga gcaatacgtt tcttcaagtt 2350081 aaccgttctc ctttctttta tgatccgaca gctgtgtggt ttttcaatcc gctcatattc 2350141 gactggaaaa ccaattgacg gtttactgcg ttcaaatagg ctttcgctga tgcttctaat 2350201 acgtcttgcg ctatgccccg ccctgctgat tcttttccgt tcaccaaaac tcttacatac 2350261 acctgggcaa atgcatcttc gccttttcta ttagactgaa tgcggtagtc taagagctcc 2350321 acatccttat cgatgcagcg ctcaagcgta ttgtagattg cttccacgct tccagctcca 2350381 gttgcagctt cctgaataag ctgtgcgttt tcttgatttt tcaaagatag agtagccgta 2350441 gggacctgac ttgttccgta atgtacttgc agagaaagaa attcataccc aatcttgcga 2350501 tctgttactt tttcttctaa aataagagaa acaagatcct catcagtgat ttcttttttc 2350561 ttctcagtca actctttgaa catcgtaaag aatttattaa tctcttcact gtcaaattgg 2350621 aatcctaaag cagtcagccg gtctttaaat gcgtggcgtc cggaatgttt acctaggaca 2350681 agcgcatctg cggttacgcc gacaagctcc ggtgaaataa tttcataagt cgatttttcc 2350741 tttaaaaagc cgtcctgatg gatgcctgat tcatgagcaa atgcattatc tccaacaacc 2350801 gctttgttgc gcgggacagc catgcctgtc agtttgctta ctaaatcact tgttctctta 2350861 atctcgttca gcgtaatacc tgtttcgact tggtagaaat cttttctggt atggagggct 2350921 acggcaattt cctctaatgc cgcgtttccg gctctttcac cgatcccgtt cacagcgcat 2350981 tcgatttgat cagcgccatt ttcaatcgca gcaagagagt ttgcgactgc cattcccaaa 2351041 tcatcatgac agtgggctga aagctttgct ttgtgaatgt tcggaacgtt ttctttcata 2351101 tatttaaaga tatttccgta ttccgccggg gccaggtagc cgacagtgtc cggaagattg 2351161 ataacactgg cgcctgcgtc aatcactttc tcgacgattt ctgctagaaa cggcagttca 2351221 gtgcggcagg catcttcagc tgaccattgc acaatcggaa aacgttcttt tgcgtatttc 2351281 accattccaa ctgctctttc aatgacttgt tcacgtgtca ttttcagctt gtgcttcaaa 2351341 tgaatgtccg atgtcgcgat aaatacatga attcttggtt gagcgccatc ctttaacgct 2351401 tcccaagcag catcaatatc accttttaca caacgggcca gaccagttac tgaacaattt 2351461 ttaatggttc ttgcgatttc ctgaacagct aaaaagtcac ctcgggacga agcgggaaat 2351521 cccgcttcaa tgatgtctgc cccgagtctt tcgagctgct tagctatggc aagtttctcc 2351581 tgtgtattca agttcactcc aggggactgt tcaccatcac gaagcgtcgt atcgaaaaaa 2351641 ttaattttgc gcaacggaga ccaccgcttc cttcttcttg ccttgtttca caaacggcat 2351701 catttcacga agctttcttc ccactacttc gatttgatgt tcgttctcgc ttgcattgat 2351761 agcgttgaaa cgaggacggt ttacttggtt ttcgacgatc cactcttttg cgaatgtacc 2351821 gttttggata tcttttaata cttctttcat agattctttt actttggcgt ccacaacgcg 2351881 agggcctgat acgaaatctc cccactgtgc tgtgtcagag attgaatatc tcattcctgc 2351941 aagtccttct tcgtacataa ggtctacgat taatttcagc tcatgaagac actcgaagta 2352001 tgcaagttca ggctgataac ctgcttcagt taaggtttca aatccggctt tgacaagcgc 2352061 gcttaatccg ccgcaaagaa ctgcttgctc accgaacaaa tctgtttctg tttcttcttt 2352121 aaatgtcgtt tctaatacgc ccgctcttgc gccgccgatt cctttagcat aagcgagggc 2352181 tttgtctctt gcttctccag tcacatcttg atagattgcg aacaatgcag gtacgccagc 2352241 tccttgctca tatgttcttc ttaccaagtg tcccgggcct ttaggggcca ctaagaatac 2352301 atctacatcc gccggaggaa caatttgatg gaaatgcacg ttaaatccat gagcgaatac 2352361 taatgatttt cctgctgtca attcatcttt gatttcagct tcgtatactt tttgctgctg 2352421 ctcatccgga agcagaacca tgatgatttc ggcttgggct gccgcttctt ttactgaaaa 2352481 tactttatgt ccgtcttctt gggcttgagt gaaagatttt ccttgtctaa caccgacgat 2352541 cacgtctact ccgctttctt taaggttcag ggcatgtgcg tggccttgcg aaccgtaccc 2352601 gataaccgct actgtttttc cagccaatac gttctctttg atatcaccgt tataatatac 2352661 ttttaccatt tcaatctctc ccttgttatg ttttatacaa tagatattgt tttattggat 2352721 gacgcctttt gctgggttcc cctcgcaaaa gccgttgtac ctgttctcgc gatttcttta 2352781 atgccataag gttttaataa ctcaataagc gcttcaattt tgttagattc acctgtcacc 2352841 tgaacaacga tgctgtctct gctgacatca acgacagagg ctctaaacgg ttctatgatt 2352901 ccattaatct ctgttcttgt tgaaggtgcg gagacaacct tgattaaggc cagctccctc 2352961 tggacaatcg attgatttgt gatgtctgtg actttcagca catcaatctg tttgttgagc 2353021 tgtttcgtta actgttcaac atcattttca ccttcaacat gaacgacgaa ggtgattctg 2353081 gaaacgccgg ctgtttctgt gtgtccaact gtaatgcttt caatgttgta atgccttttt 2353141 gtgaatagac cggtgatccg gtttaacacc ccggagcggt tcaccacagt caatgtgata 2353201 attcttttca aggtttcacc cccaccattt catgcagccc tttccccgga gccaccatcg 2353261 ggaatacttt ttcttcgctg gcaacccgca cgtcaatgac aacaggttct cttgatgtta 2353321 atgcctcttc cagcttttcc tttgcttccg cttctgatga aattctgatg cctttaatgc 2353381 cgtatgcttc ggacaatttg acgaagtcag gctgagaagc gaatttagat tctgaataac 2353441 gttcttcata gaaaatttcc tgccactgtc tgaccattcc gagacaagcg ttatttaaaa 2353501 tcactacctt gaccggaaga tttaattcgc gaataacatc gagttcttga agcgtcattt 2353561 ggaatccgcc gtctccgaca accgcgacaa cagtagcatc tttttcggcc agctgtgcgc 2353621 cgatcgccgc cggaagaccg aatcccatcg ttccaagtcc gcctgacgtg acccatttat 2353681 ctgctttttg gaacggataa aattgcgctg accacatttg atgctggcct acatccgttg 2353741 cgacaatggc ctctcctttt gtaaattgat gaatatattc aatcaatttc tgaggtttaa 2353801 aaccttcttc ttcattatct acataccaga gcggatactc ttctttccat tctgcgagct 2353861 gttttttcca ttcgcttgaa tcgctttgtt tgccgtcttg tttgatcagc tcctgcagga 2353921 caattttgct gtctccgact acaggaatct gtgttttcat gatttttccg atttcagctg 2353981 gatcaatatc gatgtgggct atctttgcgt ttctggcaaa gtgtttcagg tttcctgtga 2354041 cacggtcatc aaaacgggcg ccgatactga ttaatagatc acattcatga agggccatat 2354101 tggctgtata agtaccgtgc attcccgcca tccctaggaa aagcggatgg tcagccggga 2354161 agcctccgag ccccaaaagg gtgtgtgcca cagggatttg ctgctgttca gcataatttt 2354221 ttaattcttc tgacgctttt ccgtgcagta cgcccgcacc cgccaggatc accggttttt 2354281 tcgcactgct cacggcttcc acaagcttgc ggatctgcaa ataattcggc tctgttgtcg 2354341 gctggtatcc cgggagattc atctcatgat cgtagctgaa ttctccttca attgttgcta 2354401 catctttcgg aatatcaatc aatacaggtc cgggtcttcc agttgttgca atatggaacg 2354461 cttctttaat gatgcgcggc agatcttccg gctggcgaac ctggtagctg tgttttgtta 2354521 ctggcatcgt aatccctaaa atgtctgctt cctgaaatgc atcgctcccg attacagagg 2354581 ttgctacctg ccctgtaaag acgactaacg gcaatgaatc aatcatggca tcagcaaggc 2354641 ctgtaacaag gtttgtcgct cccggccctg acgtggcaat gacgacaccc ggttttccgg 2354701 agacccttgc gtatccctcc gctgcatgaa ttgctccttg ttcgtgacgg ggaaggatat 2354761 gtaccaaccc tgaattgtat agcttatcgt aaatcggaag cacagccccg cccggataac 2354821 cgaagatcat ttctactttc tcttttttta atgattcaat cagcattaat gctccgctca 2354881 tcgtctgtgt acattcggca gatgctgaat ccacctgtac attagtcccc attttagttc 2354941 ctccttttgg attttcatcc tttaaagatc atcttttcat tagctagata gctgattatt 2355001 caataaaaaa agcccttccg cccacaatca gccgcgcagt aactgcgata gctaaaaggg 2355061 gcgaaaaggc ttttctttcc gcggtaccac ccttgtttac ggcctgttaa tcggccgtct 2355121 catggatatt tctatccgct ttagtaacga gtgaatcaag ttcacccggc caagtcctac 2355181 tgtcatttca gactggcact ctgaggcgag ttcaccttgt aaagcttcgc cggttctcag 2355241 ctaacccggt tctctgtgga aaactttatc aaggctactt atcctcatct gcgcttttca 2355301 tattcagcct tcggaacggc tttccagctg ttcaagaagg tcgtttgttt ttcatttttt 2355361 tagaatcata ctgcgatgat tttcgcttgt gaagcttgca tttatctttt gttgaactca 2355421 tattacgccg ctttggacgc agtgtcaaca gcatttttta aaattattag acaattttga 2355481 ttaatcaatc tatattgtat acgctttcat tattggtaca aaaggaattg caaatgttaa 2355541 aagtttttat aattttttta ttaatctatc aagaatacac cagaattatt taattttata 2355601 taaacatgga agattttata acacgatatg gttcgtatat ggattgagtc tgacagatca 2355661 tcttgcaatc catttcaatt tcggataggc acttctcttg ttccctcggc atacattaat 2355721 gatatcttgc aaagaaaagg tgatacgatg aataaatcat ttgcagacat gcaaggattt 2355781 cctgcgggct ttccaagctt ccccaacttt ccgcagcagt actatcctgc tgtccctccc 2355841 ttttaccagc aaagccagca gccatttgga ggctacggat acggacagcc gttcagtcag 2355901 gcatacagcc cgttaaccac tccctctgga atgtactcct cattcccata cgcttcagga 2355961 ttttacggac agcaattttc aggtgcaggc tttagcggcc atggcggcag cttaagtgct 2356021 ccagcgatac atgccggcgg attcagcggg gcgccaggcg tacacggagg ctttagatat 2356081 taaagaatac cacaagggcc gaacatctat tgcggtcctt ttattgtttt aaaacgactt 2356141 cacaagtaca gtcacatttt ctgtctttat atttggaaac aggatggaat atgattaaga 2356201 tgaattgaac gatattctgc acaatccgta agttttcgag gaggaataaa attgcatata 2356261 aaaatagacg atttaactgg acgtcaggtg gtttcactgg tgaatgagca tttacatagc 2356321 atgacgctta tgtccccgcc agaaagcatt catgccttag gtctagaaaa actaagaggg 2356381 cctgaaataa cattttggag cgcatgggaa ggtgatgaac tagctggctg cggagcgcta 2356441 aaagaactgg acacccggca tggagaaatc aaatcaatgc gaacatctgc atcacattta 2356501 agaaaaggcg ttgccaaaca agttctccag cacatcattg aagaagccga gaagcgaggc 2356561 tatgagcggt taagcttaga aacgggttca atggcttcat ttgagccggc aagaaaattg 2356621 tatgaaagct tcggtttcca gtattgtgaa ccgtttgcag actacggtga agatccaaac 2356681 agtgtgttta tgacgaagaa attgtgagac ggctttataa ggatagataa gtgcagggga 2356741 aggtctgtct tatctatctt tttttatatt cacacatttt tcacctttat gatacacgcc 2356801 aatgttttca attttgttta attcaaagaa cagcgggaat tacaaacgac atgaacgata 2356861 tcatgcaaat tcataaagga ggagattgat atgaaaagca tagttggtgt atatgaaact 2356921 ccgcaggaaa ccatcgcagc gattgaaggc ttacttacaa aaggctatga ttctgatgac 2356981 atttctgttg tgacaagccg gcgagataca gattatttgg agtcacgtac aggaacagaa 2357041 gtcaatcaag ctatcgatgc acatcaggac gaatctgaat cttttttcga taaactgaaa 2357101 gattatttca caatggatga tactgctaca cacagcaaag cattatccga cttggatatt 2357161 aaaactgatg aaatagacaa gtatcaagaa gatttggatg acggaaaact tctggtagcc 2357221 gtcgatacag atgcagatgt aattgctcct attgataacg gcaatgccct ttcaggcggc 2357281 ttttcaagca caaatgaatt ggattataca acgaaagaag aaaaaacgat gccgctccgg 2357341 gaagaacagc tgaaggtcga taaggaagac gttcaaaccg gcgaagtaga aataggaaaa 2357401 gaagtgaaaa cagaaaaaag agatatggac attccggtga gacatgatga aatttatgtc 2357461 gaacgccgtc cagtggatga aaataaaacg gacgctgctc ccgtcaacga ttcggaagag 2357521 atcagagttc caatcgttga ggaaaagctg gaagtgacta aaaaaccggt tgtcactgat 2357581 gaagtggttg tcggcaaacg cactgttgaa gaaaatgaac atatttctga aactgtgaaa 2357641 aaagaagaac ctcgtctgaa taaagaagga aaagttgacg gcttggatga tgatccgtta 2357701 aataacaaat gaaaatcata gaccgacaac aaaaaacctc aaatcctaaa tggatttgag 2357761 gtttttcttt tggtacgtcc caggagagat tcgaactccc gaccgacggc ttagaaggcc 2357821 gttgctctat ccagctgagc tactgggaca cgttttgttt ttttgttttt cgctttaact 2357881 atcagcgaca agatttatta tatatgggat gcaataataa gtcaacggtt ttttagaatt 2357941 tttttcatga ggaagaaaat tttcttcctc atgacatttt catagtgtga ctcgattttg 2358001 cagatcctca atttcattgc ctgcttggtc gtaaaaacgg actgtcgcag catcattttc 2358061 taatgtcagt atagcatagc tttctgtcct gcgcaccctc ggaagccgga tgctgcctgg 2358121 gttaatcatc agttttccgc gcagcacttc gcttcccgcg atgtgcgaat gcccgaagca 2358181 gataacatcc gccccgagct cctctgcacg atagtatacg tttaacaagg tctgttttat 2358241 accgtgaagg tggccgtgtg tgactagtat ttttcttgag ccggcagtca gaagaagctc 2358301 gtccttaaaa tcgccggcaa aatcgcaatt gccttttaca accgcataag gctccaatgc 2358361 aggatgcctc gtctcaagct cagagtcccc gcaatgaatc atgagatcaa cttctgcctc 2358421 atgccgtttc gcaatggttt ggagttcttc ttcaagccca tggctgtcac tgataatcag 2358481 cacgttcatg tacaagcttc ctccttatgc ctccaaaagc ttagacagct ttttaagcgc 2358541 gtcagcccta tggctgattt tatttttttc atcacttgtc agttcagcca tcgtcttatc 2358601 tttatctttc acgataaaaa ttgggtcata gccaaagcca tattctcctc tcggttcttc 2358661 agcaatatac ccttcaacat ggccttcgac tgtttttgtt tcctctccgg gaatactcac 2358721 ggccagtgcg cagcggaaac gggcggtgcg ctgttctttt tcgatacctt tcagctcgct 2358781 gagcactttt tcgatatttg cctggtcgtc tttctgttcc cctgcatagc gggctgaata 2358841 aaccccgggt ctgccgccaa gattatcgat ggatagtccg gagtcatccg caatcaccat 2358901 tttgttcact gctttggcaa cagcttccgc tttcataatg gcattttctt caaatgtatg 2358961 gcctgtttct tcaatttcct ctgtgaatcc aatttcagct aaagatttga catcatagcc 2359021 tcttggctca agaatttctt tgaattcctt cacttttccc ggattatgtg ttgcaataat 2359081 tgcttctttc atgatgatca agcctttctg tctttatttc agttctggca gagaatcacc 2359141 cagcacttct ttttgcttgt caatcagctc ttggattcct ttttccgcaa gacccagaag 2359201 accgttcaga tcctctctag aaaaagttgc ctcttccccg gttccctgca attccacaaa 2359261 acggccgctg cctgtcatga tgacattcat gtcaacttca gcagaggaat cttcttcata 2359321 atttaaatct aacaaaattc cctgttcctt atcaattcca acagagattg cagcaagaaa 2359381 atcagtgatc ggatttgtct tgattgttcc tgctttgatc agcttgccaa tcgcaatcgc 2359441 catagcaaga aatgcgcctg taatggaagc tgttctagtt cctccatcag cttgaatgac 2359501 atcacagtca atccaaatcg tccgttcacc gagcttttcc agatctacaa cagctcgaag 2359561 cgcgcggccg atcaggcgtt ggatctccat tgttctgccg gaaattttcc ccttagaaga 2359621 ttctctgatt gttctttggt ttgttgcccg cggcagcatg ctgtactctg ctgtaatcca 2359681 gcctttccct ccgccccgca aaaacggcgg tacgcggtcc tcaacagacg cgttgcagat 2359741 tacctttgta tttcccgctg ttattagaac agaaccttcc ggatggctga taaaatccaa 2359801 atcgaatgtg attggacgca gctcatcgtg ttgtcttccg tcatgtctca tgttttacct 2359861 ccgattgtat gtacataaac catttttgtc ccggaattga ataaagaaag aggcagccgg 2359921 aacgctaacc tctttcttcc tagtatatca aaaatcccaa tttaaaaact acccgtattc 2359981 acttgagatg gtctggagac cggttctgtg agcttttcgc ctttttcatt taccagctct 2360041 gattttccgt tcactttaac agagacgctt tttacatccg gctgctccgt taacgtcagc 2360101 acaatgctgt tcagcacttc tgaagaaatc attttcgtct tctcatcggc gctgccgaat 2360161 atagattgat tgaaatccaa cgtcacgcgc ccgtctttga ttttcggttt gctgaccagc 2360221 tttacatctt cactgaagtc tgttaacagc ccgctcacct tgctcggccc tttagccaat 2360281 tcattaatgg ctgctgtgat gtcgtctttt tccgaattgt cgattcgttt ggtcaccggc 2360341 acgtagtatt cactgtcttc attttccgcc aaatagtaga ctgtcagcgg atgggtagca 2360401 gtgagatcat ttacaccggc tgtttccaaa ttaatgccgt ctttgcggct taaatcatct 2360461 gagatcggcg tccctcctac aggcatctcc ttcagttcat gcccgtttat tctcagcttc 2360521 actttatcta tcgaactaaa ttgcgtcagc gtccacgtca cagattgaac gattttctgt 2360581 tcgtcttctt tcttataatt tttgaactca ttagagaaat cagctatcgc cgttccatct 2360641 tttttgatgt caacgttaac ggtggtgtca gccggcaata cagctctgaa gccattcgga 2360701 agaatttcag acacaggccc gccctgtacg aggtattcaa gcgcctgctt agccgtgctc 2360761 tcacttttag gaagaggcag cgtttgcgca acaacatacc cgtttttatc aatgagataa 2360821 agctccctca taacagtaga tgaggcttga tccgcttttg cggtatcgct tttttcactt 2360881 tctgtttttt tggctgctgt tgtatttgaa ttggcacccg cttcatcgtt cacgaatgta 2360941 acgtcttgag gcggatcaat ttcctcggct gccttatcag attgaaacaa accgcatccg 2361001 gataaaagca aggcagaggt gagacaagtg gcaccaatga ctgcaggtcc ttttttcagc 2361061 atacttttcc ctcctaagga tgtttgtact attatgtata cgagcctctt taggaaatag 2361121 accgaagaat tccggcaaaa cagaaaaaaa cccgcaacat accgttgcgg ggaaaactat 2361181 cttttaatcg gttcttgcag tgagatacat tccacatgcc cgacttcatg gccaaaccaa 2361241 tcgtctgcga tttttgcaaa ctgatcacgc gcccctgttg tcaggaactg atgatccggg 2361301 gcaatcggag actggttcag cagcccttta taagagagaa ttgtgctgac ttcccgggct 2361361 gtttcatcgc cggacgaaat aatgtttacg tgctctccca tatatctttg aatggcttct 2361421 tttaaaatag ggtaatgggt gcagcctaaa atcagcgaat caattgatgt gtcttttaac 2361481 ggatacagcg aggttttaac aatctcgtct gctgttttgt cgagaaactt cccgctttcc 2361541 acaaaaggca caagcagcgg gcaggcaagg ttttcaacct tcaaatcagg gtttaatgcc 2361601 aaaagcgctt cttcgtatgc attgctctta atcgtattct ctgtgccgat gacaccgata 2361661 tgctgattat ccgtcacttt tatcgctgct ctcgcaccag gctggatgac tccgaccacc 2361721 ggtataccga cgctgcgctg gatgtcatcc aaagcgatcg ctgttgctgt attacaggcg 2361781 atcacgagca ttttgatgtg gtggttttcg agtaaataat tcgtcagctc ccacgtatat 2361841 tgaagcacct cttcttcagg gcgcggcccg taaggacacc gtttcgtatc cccgacgtag 2361901 ataatatttt ctttaggtag ctgtctcatg atttccttcg caacggttaa accgccaacc 2361961 ccggaatcaa tgactcctat tggttgttcc aacaaaatcg cctcattttc tcttcatttc 2362021 atgctgcagt ttcatcaaag atttttcgaa gatggctatt tcttcatctg taaacgattc 2362081 gaacatatca cgcagatatt cctgtctttt tgtaatgacc tcttggataa tccgttctcc 2362141 ttcaggcagc agatgtatcc tgacaacacg tctgtccgcc gggtccttga cccgctcaac 2362201 aagctcattt ttttgcatgc ggtcgattaa gtccgttgtc gtgctgcatg ccagatacat 2362261 tttgcccgat aattcaccga ttgtcatatc tcctaattca taaagccatt gcaagccgac 2362321 aaattgcggc ggcgtaatcg catattggtt aaggatttct cgtccttttt gcttaatgat 2362381 cgcggcaatg tggcggagtg acttttcaat atccgcaaca tgctccaaag gttttgatgt 2362441 catttgtcca tccctcactc aaggatctct tacgcacaaa agcgttccgt gtctattttc 2362501 cttctttttt gaagaaaatg caagactcgc aggagagaaa tagaggactt tagtcaaaca 2362561 acatcaagaa ataaaattta atttatgact tgcctacgtt ttgcacagca ttccaaatat 2362621 ggtttcgaat gttccaaaca aacagcaata accggctcct tccaaaagaa ggaataccgg 2362681 caaggattaa agctctagct cacccattct aagaagctca acaacggctt gcgaacgccc 2362741 tttcacaccc aatttctgca tggcatttga aatatggttt cgaacggttt tctcactgat 2362801 aaatagctcg cttgcaatct cctttgttgt cttatcttga acgagcaatt cgaacacttc 2362861 tctttctctt ttcgttagca gcggcttcga ttgaaattct ttctccttca agtattgtaa 2362921 ccctccttgc taaggtgaga gcgaatcaga aacgaatggg ttttgatata gtcgagatat 2362981 catatgtaag aagggcgcag gaggtgacgt ttacaagata attagtttat cgtgtatgaa 2363041 gaagcgtttc tttctcctca tccgtccagc tgacagcctt gccgctttcc tttgagactt 2363101 gaaccatcac gactgccccg gtgaagcagg gttcgccttc gaggttctct ccgagatagt 2363161 gcaaggtaag agatgaactg ccgactgcgc ttgttttcac atagatgcgc aactcttcat 2363221 aaggcatgac ttggcgcaaa taatcgcatt gctggcttgc cacgactgtc atggtctgtt 2363281 tgttttcact catcatattc agctttttaa aataagaaat ccgcacctcc tcaaaatata 2363341 taaaaggggt tacattattc atatgcccaa acatgtctgt ctcggaaaat cttacggata 2363401 ccttattgaa aaaagaaaag gatgttttcc attcttgaaa cggcatatca atataagcgg 2363461 gaagcttcat cttttttcat ctccttattg tttaaaaaaa cctctcccat gcggaagagg 2363521 ttttttcttc ttatactctg tcgcttccga agaaattgcg gaacgcttgt aagtttgtat 2363581 ctctattcaa ggctgcaatc gaagtggtaa gcggaatccc cttcggacag gattgaacac 2363641 agttttgcga gttgccgcaa tctgcaaggc cgccttcatc cattaatgct tctaatcgtt 2363701 cagatttatt catggcgcct gtcggatgcg cgttaaacag gcggacttgc gacatcggtg 2363761 caggccccat gaacttcgat ttgctgttca cattcgggca agcttcgagg cagacgccgc 2363821 atgtcatgca ttttgataat tcatatgccc attgacgacg tttttccggc attctcggcc 2363881 ccggtcctaa atcgtacgta ccgtcaatcg gtatccacgc ttttactttt ttcaatgaat 2363941 caaacattct gctgcgatca acctgcaaat cacgaacgac tgggaatgtt ttcattggtt 2364001 ttaaacggat tggctgttca agctggtcaa taagcgccgt acaagactgg cggggttttc 2364061 cgtttataac cattgaacat gcgccgcata cttcctcaag acagttcata tcccatgtga 2364121 caggggttgt cttctcacct ttgacattaa ccggattccg gcggatttcc atcagagcgg 2364181 aaatgacgtt cagattcggg cggtatggaa tctcaaattc ttcatcataa ggcgtgctgt 2364241 cagctgtatc ttgacgtgtg ataataaatc gtatggtttt ttgttcactc atgattattt 2364301 cgccaccttc ttcttcgagt aatcccgttt ccgaggcgtt atcagtgata catcgacatc 2364361 ctgatactca aattccggcg cttcatacgg gcttacatgt ttagccattg ttgttttgag 2364421 ccattcatca tcattacgtt caggataatc cggtttataa tgggcgcccc ggctttcatt 2364481 acggttgtat gcgccaaggg taatcaccct cgcaagctga agcatgttcg agaactggcg 2364541 tgtgaacatc gctccctggt tgctccattt tgtcgtgtca ttgatgttga tctttttgaa 2364601 gcgctccatt aactcctgaa ttttgtcatc cgttttcaaa agcttgtcat tatggcggac 2364661 aaccgttacg ttcgccgtca tccactcacc gagctctttg tgaagaacat aggcattttc 2364721 ggttccgtcc atactcataa tatcagccca tttttcttct tctttcttaa cgtgagcgtc 2364781 gaataaagat gaagacatgt cttccgctga agattctaag ccgtttacat atttcaccgc 2364841 attcggaccg gccaccatgc ctccgtaaat cgcagacagc agggagttcg ctcccaagcg 2364901 gttgccgccg tgcatagaat aatcacattc cccagccgca aacagtccag ggatatttgt 2364961 catttgatcg taatccaccc ataaaccgcc catagaataa tggaccgccg ggaagatttt 2365021 cattggaagc ttacgcgggt cgtctcccat gaatttctca taaatctcaa tgatgccgcc 2365081 aagcttaata tcaagctctt tcggatcttt atgagacaga tcgagatata ccatgttttc 2365141 accgttaata ccgagcttct ggttcacaca cacatcaaat atttcgcgtg tcgcaatatc 2365201 acgcggcacc aggtttccgt atgccggata tttttcctcc aggaaatacc atggtttgcc 2365261 gtctttatat gtccacacgc gcccgccttc accacgcgct gattcactca tcagtcttag 2365321 tttgtcatcg cccggtatgg ctgtcgggtg gatttgaatg aattctccgt ttgcataata 2365381 cgctccctgc tgataaacga ttgacgcagc agatcctgta ttaatcatgg agttcgttga 2365441 ttttccaaag atgattcccg gtccgcccgt cgccataatg acagcgtctg aacggaagga 2365501 ttcaatttgc atgtttgtca ggttttgtgc aacaattccg cggcaggttc tgtcatcatc 2365561 taaaacagcg ccaaggaatt cccagccttc gtattttgtg accagacccg caacttcgta 2365621 tctgcgcact tgctcgtcca gtgcgtaaag cagctgctgt cccgtcgtcg caccagcata 2365681 agcagttctg tggtgctgtg tacccccgaa tcggcggaaa tcaagcaggc cttcaggcgt 2365741 ccggttaaac atgacgccca tccggtctaa taagtggatg atcgaaggcg ccgcttcaca 2365801 catcgccttg accggcggct ggttggcaag aaagtctccc ccgtataccg tgtcatcaaa 2365861 atgttcccac ggagagtcac cttccccttt tgtattgacc gctccgttta tgccgccttg 2365921 cgcacaaact gaatgagaac gtttgacagg aacgatggaa aacaatttaa ccgccattcc 2365981 tgattccgct gctttaattg tcgccatgag gccggcaaga cccccgccga ctacgataat 2366041 gcttgattga ctcatgatag cccctctccc tctagtaatc tagtactctt aaacaaatgc 2366101 aaaaatcgct tttaagccta cgtatgacag tgcaacaaaa ataatcagcg taacgtatgt 2366161 cgaaattctt tgagaacgag gcgttaccgt gatgccccat gtaacagcga aagaccataa 2366221 accgttcgag aagtggaaaa ttgttgataa aacaccgaca atgtaaaaac caagcatagc 2366281 cggagagctc aaaatattcg ccatcatgtc gaaattgacc tcagcaccca tttgtgcggc 2366341 aatgcgggtt tcccacacgt gccagctgac gaaaatgagg gtgatgatac cggttacacg 2366401 ctgcaggacg aatagccagt ttctcatgta gctgtattga ccggcgttat ttttcgcagt 2366461 aaacgctatg tacacaccat aaactgcatg ataaattaat ggtaagaaga taataaaaat 2366521 ttccaaggca tacctgaaag gcaggctatc cataaaatga gcagcgctat tgaatgcttc 2366581 agcgcccctt gcggcaaact ggttgacgac taaatgctga ataagaaaga tgccgaccgg 2366641 tatgacgcca agcaaggaat gcaatcttcg aaaataaaac tctctgttcc cagacattac 2366701 tttaccccct gtttgataag tgcgaaatgt gctaaatctc ttcccccact tctttcaatt 2366761 gtaagcactt tattaagatt tattgacaat ttcattttac tcctccctca aaagggcgtc 2366821 aagaaaacgc gtacataaat tataattttc cgaattgatt agttgattga aaaattttat 2366881 tttatcaata tatatttctt gcttaatttt tcataagaat tacaggatca ttctgtaatc 2366941 ctcccccctg tttgagctat aatatacgca ggagagaggg gagacagata tgaagtctaa 2367001 atttgaagca tctattgaca acctaaaaga aattgaaatg aacgcttatg cctacgaact 2367061 aatacgagag atcgttctcc cagatatgct tggccaagat tactcttcca tgatgtattg 2367121 ggcaggaaaa catctcgccc gtaagtttcc tcttgaatca tgggaggaat ttccggcctt 2367181 ctttgaagaa gcgggctggg gaaccctcac caacgtaagc gctaaaaaac aggagcttga 2367241 atttgaactt gaagggccga tcatttccaa ccggcttaag catcagaaag aaccttgctt 2367301 tcagctggag gctggtttta tcgctgaaca aattcaattg atgaatgatc agattgccga 2367361 atcatatgaa caagtgaaaa agagagccga taaagtggtt ctgactgtga aatgggatat 2367421 gaaagaccca gtgtaatcaa aaaggcggtg actgcatagt cccgcctttt tgattgtcat 2367481 tacacagctg aagggtgttt tgaaagctca aatgcatcgt gaagcgactc gactgctttc 2367541 accatgtcat tttcgcttac gactgttgac actttgattt cagatgtgct gaccattttg 2367601 attaaaatgt ttttttgcgc cagtacagca aacatttcag ccgctacacc gggatttgag 2367661 accatgccgg atccaacaat agatacttta gccaatttgc tttctgtctc gattttctca 2367721 aattccagcg cgtctttata ctcttcaagc accgcaacgg tttggtctgc atcttctgtt 2367781 ttgacagaga aggaaattcc agtcttgtcc tcggcctgcg tttggataat gatatccacg 2367841 tttatgtttc ttttggcaag tgttgtaaaa atagtagaca aagttgtcag gccgctagtc 2367901 agcccgtaaa tggttactct tgtgatttga tcttcaaatg caatgcctct gacaattaaa 2367961 ttctgttcca tggatgattc ctcctcaatt aatgttcccg cttcggtttc tgtacttgaa 2368021 cgcacttcta acggcacttg gtaatttttc gcgaactcaa ctgctctcgg atgaagaaca 2368081 ccggcgccta aattggcaag ctcaagcatt tcatcgtatg agatgccctc aagttttctc 2368141 gctgatttca catagcgcgg atcggttgta aacacgcctg gcacgtctgt gtatatgtca 2368201 catttatcag cttttaaagc ggcagccaaa gcaactgctg ttgtatctga accgccccgg 2368261 cccaatgtcg taatttcaca atcctctgtc atgccttgga atcctgcaac aatgacaatt 2368321 tttccttttt caagctggtc tgctaaaacc gaagtgtcga tatctgtaat tctggcgttt 2368381 ccgtgaatgg cctccgtacg gattcccgcc tgccagccag tataagacac agcgtcatag 2368441 cctttttcct gcaatgccat tgaaaggagt gaaatcgtga cctgctcgcc tgtcgccagc 2368501 agcatatcca tttcgcgttt gctcggctgg tcagaaatag cttttgcaag gctgaccaat 2368561 tcgtcagtgg attttcccat tgctgaaacg acgacaacga cttgatggcc tttctgtttt 2368621 tctgcaattg cgcggtttgc cgcattttga attttttcga ctgagccgac ggaagtgcct 2368681 ccgaattttt gtacaataag acccatgtat taccaccctt tacattttgg ttcgtgcggg 2368741 tgaggagaaa gagcgctttg tccacaataa aaaaagcaat gagaggaata ctctcattgc 2368801 ttatcaatta atcatcataa atgattatga acaacgagat agccctccaa gaaaatgatt 2368861 tcttgacagc cttacattta ttcaatgcac ggccagcaaa taataccgat ggggttttat 2368921 ttgcttcggc gacgctcccc tttcagcctt tttcacagaa tccatctttc tccaaaggca 2368981 tactcttgaa gttcgcacct ctatcttcac catataacac gatctaacta tgaaattagt 2369041 tcacatttta tcagatctta tttaaaagga caacattatt tttgcaattt gtcgtaaagg 2369101 agctgagccg ccgctgcggg aacaccggct tttttgatgt cctcaaggct tgcttccttc 2369161 atttttttaa cggaaccgaa atgctttaac agcattttct ttcttttctc tccgataccc 2369221 gggatgtcgt ccaaaacgga ttgaaacgcg ctttttcccc ggatttgcct gtgaaaactg 2369281 attgcaaaac ggtgcacctc gtcctgaatg cgctgcagga ggtaaaattc ctggctgttt 2369341 cgttccagat acgccacctc cagcggatca ccgatcagta aatttgaggt tctgtgtttt 2369401 tcatctttcg ctaaaccggc gatcgggata tccaagccga gttcattttc aatgacatcc 2369461 cttgctgcgt tgatctgccc ttttcctccg tcaatgataa tcagatcggg cagcggcaga 2369521 ttctcacgaa gcactctcgt atagcgtctt ctgacaacct ctctcataga accgtaatca 2369581 tccggccctg taacagtttt gattttatat ttgcggtatt cctttttgta tggtttgcca 2369641 tcgataaaca caatcatcgc ggaaaccggg tttgtcccct gtatatttga gttatcaaac 2369701 gcttcaattc tgtgcggcgt ataaatattt aatgcctcac ctagtttctg cactgccccg 2369761 attgaacgct cctcgtcccg ttcgattaaa gagaattttt ctttcaatgc gattttcgca 2369821 tttttatggg caagcatgag cagttctttt ttcgggcctt ttttcggctg gtgaacgttt 2369881 gtttccagta gctgctcgat catagattga tctatgctgt ccggaactaa aatctccttc 2369941 ggaaggaagt ggttgttttt tgaatagaac tgcccgatga acgtgaggaa ctcttcatct 2370001 gcttcctgat aaagcgggaa catgctgaca tcgcgttcaa tgagctttcc ttggcggatg 2370061 aaaaagacct gcacgcacat ccagccctta tcgtacgcgt acgcgaacac atcacggtcg 2370121 actagatcgt tcatcgtcat tttttgtttt tccatcgttg attcaatatg ggcaatttgg 2370181 tcacgaagct cttttgctcg ttcaaactca agattctcag cagcttcatg cattttctct 2370241 tcaagctctt ttttgacctc attatagccg ccccttaaga aacgtgtaat gctttcaacc 2370301 agctctctgt tcgtctcttc ggaaatatcc tttacacacg gagcaaggca ttggcccaga 2370361 tgatagtaaa ggcacactct gtccgggagc ttggagcatt ttctgagagg atacagacgg 2370421 tcgagcagtt tttttgtttc ccttgctgcc tgtacattcg gatacggccc gaaatagcgc 2370481 cctttgtctt ttttgacatt gcgggtgaca atcagccttg ggtggcgttc atgggtgagt 2370541 tttatgaaag gataggtttt gtcgtctttg agcatgacgt tgtatttcgg atcatgcttt 2370601 ttgatcagat tcatttctaa aataagcgct tcaagattgg aggacgtcac aatatattca 2370661 aaatcctcga tttccgtcac aagcctttgg gttttcgcgt cgtgagaacc ggtgaagtag 2370721 gagcgcactc tgtttttcag cacttttgct ttccctacgt agatcacagt ctgctgccgg 2370781 tccttcatga gataacaacc cggttgatca ggaaggaggg cgagtttttc tttcagttgt 2370841 ttgttcatat gttacccttc cttatgttta atcctttatt tccagtttaa cacgaacgtt 2370901 tgtttttctc tatggttcac aattggcgaa taaaaaaagc gatccctcaa tcggaatcgc 2370961 tctggcatgt aagcagcgga aaattaaaga tgtttgttta caagctcttg aagcgcttct 2371021 tttggtttga agccgactga agtttcaact acttcgccgt cttttaacac aagaagagtc 2371081 gggatgctca taacgccgta ttttccggca gtttcttggt tttcgtctac atcgattttt 2371141 acgattttca gtttgtctcc catttcttga tccaattctt caagaacagg tgcaatcatt 2371201 ttacaaggtc cgcaccaagg agcccagaag tctgccagta cgacgccttc gcttgtttca 2371261 gctgagaaag attgatcagt tgcttttacg atagccatta ttgaattcct ccaatgtgaa 2371321 atgatgattt ttagtatagc atctcccatt cgttcacgct attttaatgc ttacaaatta 2371381 ttttttcctg atcacagccg gtttactcat ttttatatgg ttgaatggga tatgctcttt 2371441 ttttaaaaca caaatctgat aatggccccg atcactacaa ttgccccaat aatcattaaa 2371501 atggtacgaa gcataagatc acatctcctc ttcactgtca tgtactttac catgccctgc 2371561 cggagctgtt ttaaaacctg aaaaagagcg ccggcatgaa gctccggcgc tcttgcgcga 2371621 ttaagaatca gcacgcagcg taagtaagac gactgacatt ggcgggagtt ttactttcag 2371681 tttgtttttg ctgagcgtgt attgtctgaa ggattccggt ttgacatgat gaggatcgtc 2371741 aaacgtgtta tgcgcattca ttttttctgc cgtaagaatg actccggaat ggtccgctgc 2371801 cttgtgtagg cccctcagct cgatttccgc ctctgctttg ttttggtgat cgatgttgca 2371861 aattgtgata ttgatatcgc cttcagcttg tttcgacgct gaaatgctga tttgcggaag 2371921 cgtttcaccg ttccattcat agtcggcaga cattgtctct gtggctaaaa gagaagcgtc 2371981 ctggtgcacc ttaaacatat tgaatacatg gtacgtcggt gtcaaaagca tccgctctcc 2372041 ctcagtcaaa atcatcgctt gaagaacatt tactgtttgg gcgatgttgg ccatttgcac 2372101 ccggcggcaa tgctgatgga aaatgtggaa atgagaagcc gccaccagtg catcacgaat 2372161 ggtgttttgc tgatataaga aaccgggatt cgtgcctggc tcgggatcaa accacgtgcc 2372221 ccattcatca ataatcagcc cgacccgctg ctccggatcg taccggtcca taatcgtgcc 2372281 gtgtttttga atcaattcat cgatgtattt ggcttttttc atcgtaataa accattcatc 2372341 ttccgtgaat tctgtggctg atcctttgcc cttccagaaa tcccccggaa tcgtgtaata 2372401 atgaagactc aacccgtcca tcaggccagc ggcttttttc ataagcacgt ccgtccaatt 2372461 aaaatcatcc acatttgcgc cgcctgcaat tttataaatg tcattcccgc tgtaattgcg 2372521 gacataagtc tgaaaacgcc ggtacagatc tgcgtagtat tcgggatgca tgttgccgcc 2372581 gcagccccag ttttcattgc ccacgccgaa atatttcagc ttccaaggct cttctcttcc 2372641 attttgcttt ctccagtctg acatcggcgt gccttcttca aatgtcatat actcaatcca 2372701 ctccgacatt tcctgaacgg ttccgcttcc gacattgccg caaatatatg gctcgcattc 2372761 aagcagctcg caaagcatca taaattcatg cgttccgaat tcatttgatt caattgtacc 2372821 gccccagtga gtgttcagca ttgtcttacg gtcaccgaca ccgtttgccc aatggtattc 2372881 gtccgcaaaa cacccgcccg gccacctaag gacaggaatg tgcagctgtt tgagcgcctc 2372941 cagcacgtcc tttcgtatcc cgttgatatt ggggatgtct gagtccgttc cgacccagat 2373001 cccctcataa atccctcttc ctaaatgctc agcaaaatga ccgtatatat ttttgttaat 2373061 ggttcctttt gcgatatctg tttgaatcac tgcttgatgt tcagacatgc ctctgatcat 2373121 tcctttcata cggatatgaa aagcaccaca gtcaaatatg tgatctgtcg tttgcctgag 2373181 gagtcagcat gaatgtaagc gcttttaaag taaccatatt atatatgttc gtacatgtca 2373241 acgacatttt ctattgtttt tatatttgta cgtatgtatt tataaatatg aaaaaacccg 2373301 gacttttaaa gtccgggatt tcctttatga gtgtatattc agctgtttga attcctcagt 2373361 taataacggg acaacttcaa ataaatcacc gacgatgccg taatccgcta ttttaaagat 2373421 atcggcttcg gggtctttat tgatggcgac gatcaccttg ctgtttgaca tgccggccaa 2373481 atgctggatg gcgccggaaa tgccgcatgc aatgtacaaa tccggagtaa cgactttccc 2373541 ggtctgcccg atttggagag cataatcgca ataatcagcg tcacatgccc cgcgagaagc 2373601 cccgactgcg gcccctagca cctctgcaag ctcctgcagc ggctgaaatc cttccttgct 2373661 tttgactcct cggccgcccg caacgataat tttcgcttcg gagagatcaa caccgtccgc 2373721 cgtttttttc acgacctctt ggataacagt gcggaggtca gtaagagaaa catcaatgct 2373781 ttcgatgctc cccgatctgc tggtgtcttt ttctgaagct tgaatgttat tggggcgaat 2373841 tgttgcaaag atcatcggat cggttgaaat gacgcgttca aaagctttcc ccgagtaaat 2373901 cggccgtgtg aacacaacat tccctccggt aacgcttaca tctatagcat cagaaattaa 2373961 gcctgtttgc agacgggcag caagcttcgg tgaaagatcc ttgcccattg ccgtatgccc 2374021 gaagatgact gaatcaggat tttcttgctc gataacacct ctcatgacct ggctgtaccc 2374081 gtctgccgtg tatgttttca gcttcgggtc ctcagcggta agaactttat ctgctccgta 2374141 atgaataagc tcttgtgcaa tgctttgtac attttcaccg atgagaacac cgatgacttc 2374201 cccatctcct gaaatggttc ttcctgcagc tattgcttca aaggtgacat ttcgcaattc 2374261 cccatcgcgt atttctccaa gcacgatcac tttttttccc attctaacat ccccctgttt 2374321 ctttgaatgt ccaagtttta aatgacttta gcttcgctgc ggagcaatga aacaagctct 2374381 tttgcctgtt cagcaggctc accttggaga agcttcccgg cttctttttt cggcggcaga 2374441 aaacgttcaa tggttttcag ctttggttca gcatcctctt cgtccagatc aagatcatca 2374501 agttcaagct cttcaagcgg ctttttctta gccttcataa ttcccggaag cgatggatag 2374561 cgcggctcgt ttaagccctg ctgagctgtg acaagcaatg ggagcgtcgt tttgattttt 2374621 tcaacatccc cttcgacgtc cctttctgct tctgcatcag tgccgttgat ttcgagtttg 2374681 gtgatcgtag tgatacacgg aatgtccagt agctcggcaa gccgaggcgc cacttgtcct 2374741 gatcctccgt caatggcaac atttccgccg agaatcaaat caaactcctg atccttcata 2374801 tagtggtata aaacttgaga aatggaatat tggtcgggtt catcaagatc atcttctatg 2374861 ttgattaaaa cagcttggtc acaacccatg gcaagcgccg tacgcaattc tttctccgct 2374921 tcttcaccgc cgaccgtgac agcggtgatc gtgccgccat gcttttcctt cagctggatg 2374981 gcttcttcta tcgcgtactc atcatatgga ttaatgatcc attccgctcc gtcatcctga 2375041 atctttcctg tttcaatgac gattttttct tctgtgtcaa acgtccgttt catcagtaca 2375101 aatagattca tgatcatatc cccttttatt cgcctttgaa ctgaggcttt cttttttcga 2375161 gaaatgcctg gatgccttcc ttggcgtcct ctgactcaaa tgcttcccca aatcgctttg 2375221 cttcaagctt taagctgcct tcataggaat acaccttgtt ggaataaaga agttcaagca 2375281 aagatgccag cgtttgcggg cttttctctg caaacttagc ggcaagtgct tttgcttttt 2375341 caatcacttc tgcctcatct ttcgctccaa ttgagacaag tccgagatca agcgcttctt 2375401 ttccggatat cggttctcct gatccgatga gctccagtgc tttggctgta ccgacatatc 2375461 tcggaaggcg ctgtgtcccc gcaaaacctg gaatgatacc gagattaagc tccgggagcc 2375521 ccagcttagc atcttctgcc gcgattctga tgtgacaggc cattgcaagc tccagcccgc 2375581 ctccgagagc agcgccgtga atcgctgcga taatcggttt tggaaaactt tcgattctct 2375641 ccattaactg ctggccgcgc tcagcgagca atgaggaatc ctcattgcct ttaagcgatg 2375701 taaattcttt aatatcagcg ccggctgaga aaaatcttcc ctcgccgtga atgataatgc 2375761 ttcgtacgcc tgcatctgtc tcacattgat caagacagga agacagctct tctaatatcc 2375821 ggcttgaaag cgcgtttgcc ggcggattgt gaatcgtcaa gactgccaca aattgatcaa 2375881 ccgcaagtga aattgcattc ataggacaga actcctttac ttattgtgaa ttccggatac 2375941 caataattct aaaacgctgt ttgaaagcgc aacgagatcg tacttttggt cattcatcac 2376001 ccaagttgtc acagtttcgt caatcgttcc aaaaatcatc tgccgggcga ggcggacatc 2376061 gaggccttct tttatttcgc ctgattgtat accttccgtc aaaatgccat ccaaaatatt 2376121 taagtagcct tttaatattt cgttgatttt ttggcgcagc tccaagttgg attggcggag 2376181 ctcaagctgc gtgacaatgg cgagattatg gtcacccgct aaaagggaaa aatgctttga 2376241 aatcacaagc gccaatttct ctttcgctgt tgctttttct ttaatgtcct cttccatccg 2376301 ctcaataaat tgacccattt tttctttgaa aagagaaatt aaaatatctt ctttgttttt 2376361 aaaatagaga tagatggtgc cgtccgctac cccggcttgt ttggcaattt tggatacctg 2376421 tgactggtgg tagccgtttt ctgcaatgac ttctactgct gcatcaataa tctgcatata 2376481 ctttggccgt ttttgcttca atgttcatcg ttccttccta tagaaatgaa tgactattca 2376541 ttcataattt catgataaga aggattttca ggtttgtcaa gtttattcat aggcgttctc 2376601 tttttttatt tgatatgatg attttcggtt tcttcttcaa gtaaacgcct tcttaaaatt 2376661 tttcccaccg ccgttttcgg cagctccttt ctgaactcat aggctttggg caccttatag 2376721 ggagctagac gtgatctcgc aaaagcgtcc agttcttctg tatcggcttt tgcgcctttc 2376781 tttaatacga caaatgcttt tactgtttct cccctgtagg aatcgggaac gcctgcgaca 2376841 acaatttcct ggatggcttc atgttcataa agcgcttctt ctacctcacg cgggtaaata 2376901 ttgtaaccgc cggcaatgat gatatccttc ttcctgtcag caatatagaa aaagccttct 2376961 tcatccatat agcccatgtc cccggtgaac agccagccat ctctcagcac tgcggcggtt 2377021 tcctctggtt tattccagta tcctttcatg acttgcggac cttttacaat gatttctcca 2377081 tgctcatacg gagcggcaag ctcacccgtc tcttcagaat agatcgcagc gtccgtactc 2377141 ggccaaggac agccgatact gcccggcttg ttttttcccc agataaagtt ggcgtgcgtc 2377201 actggggatg cctcagacaa accatagcct tccacaagct ttccaccagt caccttttca 2377261 aatttctgct ttacctccac ggggagcgcg gctgatccgc taagacagct tttaatggat 2377321 gacagatcat aatgctgcaa ttcagggtga tgcaaaaggc caatgtaaat tgtcggtgcg 2377381 ccaggaaaga gcgtcggttt gtgtttgtcg atgattttaa gtgtttcgag cggatcaaac 2377441 ttaggaagaa gaatcatttc gaagcctagt ttaatcgaat agttcatgac tgccgtcagt 2377501 ccgtagacat gaaaaaatgg aacgatgccc agcacttttt cagcgccttc tttcacgtca 2377561 tacatccaag cggcgcacat ttcagtattt gccaaaatat tttggtgcgt gagcatgacc 2377621 ccttttggag ctccggttgt tcctccggta tactggagga cagcgatatc atgctcagga 2377681 tcgatcttcg ggattgtcag gagttcagtt ttttcctgct tcatacagga agcgaacgtg 2377741 tgaatgttag ctgttttgtc aaagtcgata tgcacttttt gtttttgcgt cagcgggtaa 2377801 agaatatttt tcggaaaagg caaatagtct tttacactgg ttatcaaaat ctggtcgact 2377861 attgataacg ttttcatttt tattgccttc gggaaaagca aatctaaggt gatgattaca 2377921 cttacctgag catctctaag ctggtattca agctcatgct cggtataaag cggattcgtc 2377981 tgcaccacga tgccaccggc aaacaagacg ccataataag aaatcactgt ttgcgggcaa 2378041 ttgggcagca taacagccac tctgtctcct ttttgcaggc cattgcactg caaaaaagct 2378101 gcaagtttaa gagcatccgt cagaatgtca tgaaaggtga gtttttttcc ataaaacgat 2378161 attgcggttt tatcagggaa tcgtgcggcg gagtctgtca ggatggattg cagggtttta 2378221 ttcggcaacg gaagctcatg cgggatatcg ttgggatact cggcaagcca cggcttttga 2378281 gactgcataa aacctcccct ttcgatttta gagatccacc ttatcattat agcagatgga 2378341 cggcaaaaaa aagaaaaaga aaggtaaatc tttctttttc tcataatatg aacagatata 2378401 taagaccaat taacaaaaag attcccgctg cggcgagcag tattttcgca agcttttcca 2378461 tctattctcc gtccccttat attccggctg ccaccacaaa agaaagcccg acagaaatga 2378521 caaatgaaat aaagccgaca gcccggttat cattttcgat ttcctgatca attttaaacc 2378581 gcggagtcaa aaactcaaaa ataaagtagc tgatcagaag cataacaaac ccgtaaacgc 2378641 cccagccgat catttgcagc agcgaattat gctgggagat ggaatgctga aatacgtttg 2378701 cgattcccaa aatttttccg ccggtcgcca ttgccaccgc aagatttcct ttttgaatct 2378761 cttcccagtt tttataagcc gtcaccagct caaacacagt caaaaagagg acgaggcaga 2378821 gaaccgcgac actgtaatat gccgcgattt ccacaagctc gttttcccaa aaatcactca 2378881 tggccatact cccttttatt ttagttcaac aaccgtaacg cctgatcctc cctcacctgc 2378941 ttcaccgaaa cgggaacttt tgacgctgcg gtggtttttc agaagatcct gtacgccttt 2379001 tcttaaagcg ccggttcctt ttccgtggat gattgacact cttggatatc cggctaacac 2379061 cgcatcatcc aagtattttt caacccggct gagggcattt tcatagcgtt cgccgcgaag 2379121 atcaagttca agcgatacgt gatagtcctt tcctttgacc gctgtaatca ttttttcttt 2379181 ttttggctcc ggagctgatt tgataaactc cagatctttt tcttttactt tcatctttaa 2379241 aataccgatt tgaacgttcc attcattgcc gcctgttttt tcgagcaatg ttcctttttg 2379301 cccgaaagtg aggactttca cctcgtcgcc aggcttaaag tcgcgttttt gcgttttcgg 2379361 cttttccggt ttcttggact tttcaaaagc aggcatagcg ccttctaacc gtttcttcgc 2379421 gttaatcagc tcgtgatcct tgaaggattt gtgttcttct tttatggtgc gcaattcatg 2379481 aataatgtcc tcggcttctt tcattgccgc ttttactttt tcagcagcct gctgttctgc 2379541 ctcttcaagc attttgtctt ttttgctgtt aagctcgatg atttgctgct gcagctcttt 2379601 atgcagtttt tccgcttctt ttctgattga ttctgtctca gaaagctctt cttccgcacg 2379661 ttttttgctt tgttccagcg acgcaatcat cgtatcgact tcgttatgct cggccgtcat 2379721 ttctgacttc gcctgcccga tgatatggtc cgggagcccg aggcgttttg aaatttcgaa 2379781 agcattgctt cgacccggca caccaattaa aagtttatag gtcggtgaca gcgtttcgat 2379841 gtcaaattca acgctggcat tcatgacgcc ttctctgtta tagccgtacg ccttcaattc 2379901 cggataatgc gtcgtagcta acactcgtgc attggtgcga tgcacgtcat ccaagatgct 2379961 catggcgagg gccgccccct cctgcggatc tgtccctgca ccaagttcat cgaaaagcac 2380021 aaggctgttt tcattgacct gttctaaaat gccgacaata ttcaccatat gggatgagaa 2380081 cgtacttaaa ctttgctcaa tcgactgttc atcaccgata tcagcgaata cgtgctcaaa 2380141 tactgccgct tctgaccctt catctgccgg gatatgaaga cctgactgcg ccattaaggt 2380201 tagcaggcct aacgttttaa gggtgactgt tttccccccg gtgtttggcc ctgtgatgac 2380261 aatggttgaa aaatcgcggc caagctcgat gtcattggca acaacctgat caggcggaag 2380321 caatggatgg cgggcttttt tcaaacggat aaagccggtg tcgttcataa tcggttttgt 2380381 cgctttaacc gcttttgcat atctagcttt tgcaaaaata aagtcaagcg tctgcagcac 2380441 ttgcaaatct agaaatagct cctctgtata ctctgccgtt ttctctgtca gcacacgcaa 2380501 aatccgttca atttcttgct tttctttcac tttcgcctgc tgaagggaat tgttcatatc 2380561 tacaatcgcc tgcggttcaa tgaatagtgt cgcaccagag gatgaggtgt cgtgcacaat 2380621 tcctccatag ctggatctgt actcctgttt gaccgggatc acaaagcggt cattccgaat 2380681 cgtaacaatc gtatcagaca gcattttcga tgcggaagag gaacgcagca tcgactctaa 2380741 ccggtctctg actcttgatt cgagtgttct gagctgtgtg cggattcctc ttaatgtttc 2380801 cgatgcatga tcaagcactt ctccgtgatc atcaatgcag gaattaatgt cccgctctaa 2380861 atcggacagc gtgataagct gttcagcatg ctgatggatc agcggaatgt cgacaccgtc 2380921 ttcagccatt tgcgtgataa aatgtttcat ttgtttaact gcataaagca ggcctgagat 2380981 ttcagtgaat tcagaaggac tgagaacgct gccgatttcc gcccgtctta acgctcctct 2381041 gatatctaca aggccgccaa atggcgcttg gcctctcagc cggataatgt cagaagcttc 2381101 gtctacttca tccagctgtt ttttgatttc gtctatagaa gcagaaggct taagctcgag 2381161 aagcatttct tttccgagcg atgaagcggc atgcccaata acctgttctt tcactttatg 2381221 aaattcaaga gctgataata ctttttgctg cacgattgtg tgagcctcct tacttaatcg 2381281 ttgcgcttca gaaatgcctc tacgtcttta agcgaccggg cattcagaac gtttttcgtt 2381341 tccgtccatc ctttgcgcgc ggcagtaacg ccagttttca tatcgtctaa catctcaata 2381401 ttatgggcat cagtattaat caccaatgta accccttgtt cgtttgcttt cattaaatgc 2381461 tctgtgcgca gatcaaggcg cgcagggttg gcattgagtt caagcgccgt atttgttttc 2381521 ctcgcaagct caatcagctg atcaatatcg atttcgtaac cggcccgtct gccgataagg 2381581 cgcccggtcg ggtgtgcgat aatgtcaaca tgcttgtttg tcagtgccgt ctcaagccgt 2381641 ttcataatca cgtgttccgg ctgattaaaa ctggaatgaa tcgatgcaat aacgatatcc 2381701 atttccgcaa gcacatcgtc atcataatcg agcgtaccgt caggcaggat atccatctca 2381761 acgcctttca aaatacggaa gttttcaaac tctgcattca gcgcgtcaat ttcttttgcc 2381821 tgctgcttaa gtctttctgc agtaagcccg ttggcgacct ttaaatattg tgagtgatcg 2381881 gtgatcgcca tgtattgata gccttttttg atgcaggctt cagccatctc tctgatcgaa 2381941 aatgcgccat cgctccacgt tgagtgcatg tggagatcac ctttgatttg cccgagctct 2382001 atcagttcaa tgctgtcgct gtaggtttcc acttcctgtc cgctttcacg aatttccggc 2382061 ggaatcagcg gcaggccgaa gtgcgcataa aattcacgtt cactcggaaa tgttttgatc 2382121 tctccggttt caactgtctc aacgccgtat tcactgatcc gctcgccgcg ttctttggcg 2382181 atttggcgca tcttaatatt gtgatccttt gatcccgtaa aatgatggag tgttgtcgga 2382241 aactgctctt ccgtcacaag acggaaatcg acgcttgttt catattcaaa ggaaaggatg 2382301 acggacacct tcgtatctcc gcttgcgatc acgcttttga tgtttggcag ctcaagaagc 2382361 tgctctctta cttcagccgg atgatctgta gcaatgatat aatccagatc cttcaccgtt 2382421 tcccgcgctc tgcggagact tccggcacga gaaaatttga tgatatgcgt aaattgagaa 2382481 agatgctcct caatttcccg cgcgatccgg agggcgtagc cgatcgggaa ccgttcaggc 2382541 tgttttccgg cttccccgag cgcctgtaat attttttctt ccgatttttt gccgaagccc 2382601 gcaagaccct ggaccttttg ctgctcacag gcttccttca gagattctgc atcgtgtacg 2382661 ccgagctctt tatacagctt tgcgattttt ttgccgccga gccccggcag cttcaataaa 2382721 ggcacgagtc cttccggcac ttctttctga agcgattcga gcgtgcttga ctttccttca 2382781 tctatatact ctttaatgac gctgtacgtt ccttttccaa tgccggacag cgacatcata 2382841 tcgtccattt ctgataagct tcggtcgtcc tgttccagag ctgccgccgc ttttcggaag 2382901 gcggatactt taaacgggtt gtcccctttg agttccatat agactgcaat ggtttcaagc 2382961 agccggataa tatctttttt atgcatatca taacccccag acgttcacat atgtttccat 2383021 catacttgaa aaaaacttct ccggacaaga gaagtttttt tatgccccgt actgtgtcca 2383081 cagctcttgt aaaagccctg acaagtacgg tgtatggtta atgatcacat ttgcgagaga 2383141 cgattgcccc atcatttgct gcaacgcgtc taccggcaga acggatgcga catacagcag 2383201 cacaaatgta aataaataga cttctagaaa accgagaacg gctcccagca tctggttgat 2383261 ttgtttaatc accggaatgc cggctacaat actcaggaac gagccgatga ttctcagtaa 2383321 gattttagca atgataaata aaacgataaa cgcaatcgca ttatagtacg ctgcttccaa 2383381 attccccgta aaaaaagaaa gagccggctg tcccgctgaa aaatcgggtg cgggaatcca 2383441 atgtaaatgc ggtgccacgt ttttatagaa taaagccgca aaggcaattg ataaaataaa 2383501 gctcgtcaag cggataaact gcaggataaa accgcgtttt aaccccagta aagtccccat 2383561 caggagcaag attaagatga tgatatctag catagttgtt caatcctttt ctttaagctg 2383621 acgctccagt ttttcacatt tctcttgtaa tttgacataa tcgtgcacca catttaccgc 2383681 tgtcagcact gcaagtttat ttatatcaag gtatggattt ttttcattga tttctctcat 2383741 tttatcatca acaattccgg cgacatacct catatgggct ctgctttctt caccgacaat 2383801 cgtgaagtgc tggccgtaaa tgtcaacggt tgtttttgtt tttttgccgt cagacaacgt 2383861 ttctcctcca ttccgcgaga atcctagttc ttatcataac acgtttatta aatgaatgga 2383921 aagacgagcc tcccgctgtt atgatacact ggtatataca gcgaaaagtg taaaaaaagg 2383981 agattattac gtgtcccatt cagtgataaa agtatcgttg tctgctattg accaaatgaa 2384041 aatgacgtac agcggttcac ttacagcctc tgttccgcag ggagccgttt ttcaggcaaa 2384101 accgcccggc tgtaccatta cagcatatca atcaggtaag gtcttgtttc aaggaaaaaa 2384161 cgctgcggca gaatccgcgc gctggggaac agcagagcct caggaaaaga agaaaacggc 2384221 caaaaagccg gctgatcccc gctatgcccc tccggcagat atcgccggaa tgtctgttat 2384281 cggttctgac gaagtcggaa ccggagatta ctttggccca atgacggttg tatgcgcgta 2384341 cgtcgacaaa accatgcttc ctttaatgaa ggaactcggt gttaaggatt ctaaagattt 2384401 aaaagatccg caaatcatcg agattgcccg aaacctgatt aaaaccattc cgtacagcct 2384461 gctggtgtta aagaatgaaa agtataacag catgcaggaa aaaggcatga gccaagggaa 2384521 aatgaaagct ttgctgcaca atcaggcgat cacacattta ttaagaaaat tggatggagt 2384581 aaagcctgaa gccattttga ttgaccaatt cgctgagcca ggcgtctact tcaatcattt 2384641 aaagggcaga gacattgtga aggagcggac ctattttagc acaaaagctg aaggtattca 2384701 cctggctgtc gccgctgctt caatcattgc aagatattca tttttaatgg aaatggataa 2384761 actatcacgc gcggcaggaa tgacgcttcc aaaaggggcc ggtccgcacg tcgatgaagc 2384821 ggccgccaag ctgatcctca aaaaaggggc atctgcactc agaaccttta caaaactcca 2384881 tttcgccaat acgcaaaaag cgcagcgcct tgctgataaa aaacgttcat agaaaaaagc 2384941 ttgcagattt ctctgcaagc ttttttatca gcctcttaaa acagcttgat atgtgtcttc 2385001 taacgctttc agcactttgc tgtgcgcctt tgtcacttct tcttcagtca gtgtttgttc 2385061 aggattgaca tactggagtg agaaagcgac tgacttcttg ccttcctcca tatgctctcc 2385121 ttcgtatacg tcaaatacgg ttacctcttt cagaagcttg cccccggcct ctttaatgac 2385181 gctctcgagc tgtccgcttg tgacggtttt atctgttaca agagcgatat cacgtgtcac 2385241 agacggatat tttggaatcg ccgtgtaaac aagcggtgct gtttctgctg cgagcaacgc 2385301 atgaagatcg agctcaaata cgtatgtttc ctttatatcc agttcttttt ccaatgaagg 2385361 atggacttgg ccgatgaagc cgatcagaga accattcaat aaaatgttcg ctgttctgcc 2385421 cggatgcagc tgtttgcgtt cagactgtac aaattcaatg ctgtctagga cgttgagttt 2385481 gtctaacagc ccttccacaa ttcctttgac aacaaagaaa tcaactggtt tcttttcacc 2385541 ctgccatagc tgcttgcgcc ataatccggt aacagctcct gctacgcgtt ctgtttcaac 2385601 aggttttgtg tcctcttcct tcgttaggaa aacggagcca acttcgtaca gtgcaactga 2385661 gtcagtctgc ctcgcaagat tgtaagaaac agaatcaagc agatttggaa caagactgtg 2385721 tctgagaatg cttctttctt cactcattgg aagcgcaagc acagtattca gtgatttttc 2385781 aatcgcaaac gctgtcgctt tcttctcgtt tgtcagtgag taagtgatgg cttgtgataa 2385841 gcctgcgcct tcaaggaagc gtctgacttt acggcgtttt gcctgatatg gcgttaatcc 2385901 gcctgtagtt cccgctgtct caggaagcgt agacggaatg ttatcgtagc cgtacagtct 2385961 tgccgcttct tcgattaaat cctcttctat tgtaatgtca ccgcgccgtg atgggacagt 2386021 cacaacgaga agatcatccg cttcaccgac cgtaaaaccg agacgtttat aaatgctgat 2386081 cagttcttct ttactgatcg tcaggcctag aacgctgctc actttgtcag cagatacgtg 2386141 aatgttattt gcttcgattg tcaggtgatc ttcctcaacc gttccagcaa gcacctcacc 2386201 gccggcatac agatggatca gctgcgcagc ccgttctgct gcaagacgta cgcgtgccgg 2386261 atcaattcct ttttcaaatc ttacgcttga ttcacttctc aaaccaaggt ctttggaagc 2386321 cttgcgaacc ttctgcccgt tgaaatacgc agcctcaagc aaaatggttt tcgtatcttc 2386381 ctgaacctct gactctgctc ctcccatgac accggcaacg gcctgcgctt tcgttccgtt 2386441 tgtaatgaca aggtgatcgg cagacagctt acgttcttga tcatcaagtg ttacgatcat 2386501 ttcattctca gctgcttttc ttactacgac ttccttagag ccaaatctgt cataatcaaa 2386561 cgcatgaagc ggctgtccgt attccaacag gacaaaattt gtgatgtcaa cgacgttgtt 2386621 gtgcggacga atgcctgcat tcatcagctt tgtctgcatc caaagcggtg acggagcaat 2386681 cgtgacattt ttaatgattt ttgcagtgta cagcgggttc gcttcttgat cttcaatttt 2386741 gactgaaatg taatcagacg cttgttctga agcagccggg taatccgttt gcggaagctt 2386801 tacctcagtg tctaaaatcg ccgcaacctc gtaagcaaca ccaagcatgt tcatggcatc 2386861 cgcgcggttt ggcgttaaac ccagctcaag aatcgcatcg tcaagctgta aagccgctaa 2386921 ggcatcgctt cctgtttcag cgtcattcgg gaatacgaaa atgccttctg catactcctt 2386981 cgccacaagt ttgctttcga taccaagctc ctgtaaggaa cagatcatgc cgtttgattc 2387041 ttcaccgcga agcttggctt ttttgatttt gaaattgccc ggcagcaccg ctccgactgt 2387101 tgcaactgcg actttttgtc ccttatccac attcggcgcg ccgcaaatga tttgtacagg 2387161 ggcttcagct ccgatatcca caaggcactt attcagctta tcagcattcg ggtgctgctc 2387221 gcgctccagc acatggccga tgacaacgcc tttgatgcct tctcctttgt attcaattcc 2387281 ttcaacctca ataccggctc ttgtaatttt ttcagcaaga acagccgggt ccatgccttt 2387341 taaatcaaca taatcctcta accatttata agaaacaaac atccttgcat cctcctctta 2387401 cgcctgttta aactgcgaaa taaatctgac atcgtttgta tagaagtggc ggatatcatc 2387461 aatgccatat ttcagcatcg cgatgcgctc aacacccatt ccgaatgcga agccctgata 2387521 ttccttcgga tcaaagccag ccattttaag cacgttcggg tgaaccattc cggcaccgag 2387581 gatttcaatc cagcctgttc ctttacatac tgagcagccg ttcccaccgc atttaaagca 2387641 tgtcacatcc acttctactg aaggctcagt aaacgggaag aagcttgggc ggagtctgat 2387701 ttcacggtct tgcccgaaca tttttttcgc aacaagttca agcgttcctt ttaaatcact 2387761 catgctgatg tttttgtcaa cgacaagccc ttcaatttgc ataaattggt gagagtgcgt 2387821 cgcatcatcg ttatcacggc gatatacttt acccgggcaa atgattttaa cgggaccttt 2387881 gccttcatgc ttttccatcg tacgtgtttg gacaggagaa gtttgcgttc tcatcaaagt 2387941 ttcctctgtg atgtaaaagc tgtcctgcat atcgcgcgct gggtgttctt tcggaagatt 2388001 gagcgattcg aagttgtagt aatccgtttc aacctctggc ccttcctcga ctgtgtagcc 2388061 cataccgata aataaatctt caatttcttc aatgacaaca gtgagcggat ggcggccgcc 2388121 gactgcaaca gggttccccg gcagcgtgac gtcaattgtc tgtcctgcaa gcttctgttt 2388181 catttcctct tcttcaagct tctcgttttt gtcagcaatc gcattggcaa tacgctccct 2388241 tacttcgttc gcgagcgccc ccatttttgg acgttcctca gcagaaagct tgcccattcc 2388301 gcgcagcact tctgtaatcg gccctttttt tccgagatat tgcacccgaa tatcattgac 2388361 aaccttcaat gagcttgccg cttctacttg ttctaaagct tcttgttcca gctgttttag 2388421 cttttcttcc attttgcatc ctccttttat gtaaacaaac cgtcatatgt ctttggaaaa 2388481 taaaaaaaac ccgtcccttg tacaagggac gagttgtggc cgcggtacca cccttatttc 2388541 agacagactg atgctgtcgt cagcttcatt gacataacgg aatcagattc cggttcacct 2388601 ttacgcgcag tgtacgcggt cccggcgaca actcaagagg tgaagccaat ttccggctgc 2388661 gttaaaaatg ctctcagtca gcggcatttt ctccctggaa agcagttgat cagaaattga 2388721 ggtcctctgt cacggttttt gaaatattat gttctattat agagaaatcc aacgcttggc 2388781 gcaacactat cctcgcaagt gatacacgag gatggcagcc gcaaccgcaa cgtttagtga 2388841 ttcagcctgt ccgtaaagcg gcacgtacag gttcaaatcc gttttttcca gcaatgcagc 2388901 atctacccct gcaccttcat ttcctacaat gagcgcaaag gattcagact gaggaatctc 2388961 ctggtaaggc gctccgtttt gcagcgccgt gccgtatact tttacgccct ctgccttcaa 2389021 ttcgtccaca tatgaaggca ggtttcttct cacaacagga atatggaagt gagatccttg 2389081 agcagatcgc agtgtttttc cgttaaaggc gtccgccgtg ccgtcaccga gtacaaccgc 2389141 atccaaaccg gccgcatcag ccgttcgaat cattgtgcca aggtttcccg gatcttgaac 2389201 agcgtcaatc agcagcacct tgcgtgccgt tgccagcttt tcttcaggca tatggcacac 2389261 agcggcaatc tgctgcggcg tttcggtttc agtcacagct gaaaacgcat cttcactcag 2389321 catatagcac tggataccag tctcaagatc tgaaggaatc ctcgtttcat cctttacaag 2389381 gatttctttc acaatgcccg ggcttttcaa cgcctcttca acgaggtgtt ctccctctat 2389441 cagaaatgta tttgtttttg ttcgttcttt ttttgtgtga agctttttcc aatccttcac 2389501 tttttggttt tttgccgatt ctatttgttt cactgtctat gtggcgctcc tttttttaac 2389561 atgatgttat tatatcgcaa gaacagcaca taataaacca ggtgcagggt tagaatatac 2389621 gtattacatt ttagaaaaag gagcgtttta catggatctt aatttacgtc atgccgtcat 2389681 tgccaatgtc accggcaata atcaggagca gcttgagcat acaatcgtag atgcgattca 2389741 aagcggtgaa gaaaaaatgc ttccagggct cggcgtttta ttcgaagtca tttggcagca 2389801 cgcatccgaa agtgagaaaa acgaaatgct gaaaacgctt gaaggcggat taaaacccgc 2389861 cgaataagac atgaaaccgg gtgacagcgc ccggtttttt tcttatataa taaaaacatg 2389921 atgaggggga acgccatgtt tttacagccg ttattagcga aaaaaattat tgctgaagtt 2389981 aaaaaaatgt acgaacgtga agtcattatt gtaaacacgg acggtcttat tatggcaggc 2390041 acaaacgatg agcgtgtcgg acaatttcat gagggagcgc ttatctgcgc aaaagaaaga 2390101 cgcagcgtga ttattacaaa agaagatgaa acaaggttaa aaggagtgaa agcaggcata 2390161 aacctccctg tattttttga ccatgatgtg attgccgtct tcgggctgac aggtgagcct 2390221 gcagagattc agccattcgg agaactgctt cgaaaaatga cagaactgtt cattaaggaa 2390281 tcgcggcact tagagcaatc ccagtggcgt gagagaatgc tggagtcctt tatgatcgat 2390341 tggctgcaat taaaggagtg gtctcccagt tttcttgaga aagctcagct tcttggtgtt 2390401 gacctttctt cccggcgcca aatgattctt attcaggggt atgagtggtc acctcatgat 2390461 attgaacaaa tggcacgcag ctggaaatcc tcgtaccctg cggatttgtt catcaggtgg 2390521 ggaaatgaac ggattttgat taatcatgaa gtgccgcagc atgaacaaag ggatcggctt 2390581 ttgcggaaaa tccttcacat ttgttcgttt gccaataccg caagcagcca atatacagca 2390641 gctggcgccg gaagggctgt cgcaagctcc agcctgacag attcatacga gcaagcggaa 2390701 aaagcgctgg ctgtcagcct taagcgaaaa acgcccatat ttgaagagga tctgaagctt 2390761 gatatgtgtc tgacggagat cagcccggga acccgaaacg aatttccgca aagagtatta 2390821 ggaaaggcgc tagagcatca ggaacttatg aatacgatac ggactttctt tcatcacgat 2390881 ttgtctttga aacaaaccgc tgaagacatg catatacaca tcaatacatt gcgttatcgt 2390941 ctggctaagg ctgaacagct gacgggatta cgttttgacc gtaccgagga cgtcgtcacg 2391001 atgtacgtcg cactctattt tttagatcaa gatacaaaat agagagagtt tcagtttcat 2391061 tttttgtatg tttctccatg gaaggctttg ctttttttct tttacaatag attgaaagcg 2391121 ttttttgaca gggggatggg tgaaatgatc accaaggatg taaaggagca gctgattcag 2391181 gtctccggac cagaaaactt tgatgactcg aatgccggcc gtctcgtcta ttcatatgat 2391241 gcgacgcctc agtatcagtc tatgcctgat gccgtgattg ctccgaggaa tactgatgaa 2391301 atatcacgca ttttaacaat ttgcagcgaa catcgagtgc cgatcgttcc aagaggatca 2391361 gggacaaacc tgtgcggcgg cacgtgcccg actgaaggcg gacttgtgct tctctttaag 2391421 cacatgaacc agattcttga aattgatgaa gaaaatttaa ctgccacagt tcagccgggc 2391481 gtcattacgt tggatatgat ccgggcagtt gaaagcaaag gtttatttta tccgcctgac 2391541 ccgagttcta tgaaaatatc aactatcggg ggcaacatca atgaaaattc cggcgggcta 2391601 cgcggattaa aatacggtgt cacccgcgac tatgttattg gactggaggt tgttctcgca 2391661 aatggtgaca tcatccgcac cggcggaaaa ctcgcaaagg atgtggccgg atacgatctc 2391721 acacgtcttt ttgtcggctc agaaggaaca ctcggcattg tgacagaggc aatcgtcaaa 2391781 ctcgttccaa agccggaaac aaagaagacg ctgcttgccc tttatgaaaa catcgatgcc 2391841 gctgctcaaa cggtatcgga cattattgcc gcaaaaatta tacccgctac gcttgaattt 2391901 ctcgatcagc ctacactatt ggtgattgag gattatgcca aaatcggact tccgacaagc 2391961 gcaaaagcag ttctgttaat tgaacaagac gggccatttg aaactgttga acgggatatg 2392021 gaaaagattg aggcgatctg caaaaaaggc gacgccgtat ccgttcagac cgcacaaaca 2392081 gaggaggaag cgtttgccct gactgaagcc cggcgttctg cactttctgc cctagcccgc 2392141 ctcaaaccga cgacgatttt agaggatgcg accgttcctc gctcagaaat cgccaatatg 2392201 gttaaagcga ttaatgatat tgctgctaaa tatgatattt ccatctgcac ctttggtcat 2392261 gcgggagacg ggaaccttca cccgacatgc acgacagaca taagaaataa ggatgaaatg 2392321 gaacgtgtcg aacaggcttt tgccgagatt tttgagaaag cgattgaact tggcgggacg 2392381 ataaccggag agcacggagt cggggaaatg aaagcgcctt acttggaaat gaagctgaaa 2392441 aaagaaggca ttgatgcgat gaaagcgttg aaagcggcat ttgacccccg gaacatatta 2392501 aatcccggca aaatgtttgc gaaagatgcc agaaaacgtg tggtggcgga aagatgacaa 2392561 cagaaaaaga aatgaaacag atccaaaatg aatttaaaga gcgtatggat gaaggagagt 2392621 tattaaattg tatgcgctgc ggcttctgtc ttccttcctg tccgacctat atcgaatcgg 2392681 gatttcagga aacacactct ccgcgtgggc gcatcgcctt aatgaaagcc gtagccgacg 2392741 gtatgattga accggatgaa gatgtcgaac ggtcgctgtc actttgcctc ggctgccgcg 2392801 cctgtgagcc tgtatgcccg tctggcgtga aatacgggca gctgcttgag gaagccagag 2392861 atattatcca ccaaaataaa aaacactctc ttggtgaacg tgtcatgcga aagacggctt 2392921 ttcacgagct gtttccgcat caaaaccgca tgcgctcagc tgtaagcctt atcggtttgt 2392981 atcagcgttc aggactgcaa accgctgtgc gaaaatcagg catgcttcgg gtcctgcctg 2393041 agcatttgcg gacgatggaa gctgttcttc ctgatgttcc aaaaagcaaa gacatgaaac 2393101 atcggccgcg tttcctgcct tccattggcc ccatgaaaaa acgggtcgcc tttttttcgg 2393161 gctgcttaat ggatacaatg tttttaccga ccaataacgc cacattgaag cttttacagc 2393221 tggcaggctg cgacattgtc attccgcctg aacaggcttg ctgcggggcg cttcatggac 2393281 acagcggtga aaaaaacaca gggaaagagc tcgcgaaaca aaatatcgct gctttcgaag 2393341 cattagacgt ggatgcagtc attacaaacg caggaggatg cggagccttt ctcactgaat 2393401 atgatcattt gctgaaggat gaccctgagt ggtcggaacg ggctgccgct tttgttcaaa 2393461 agctgaagga tttttcttct gttttggttg aactcgattt ccatcaaatg gatctagcac 2393521 tcgagacgcc tcaggtcgtt acctaccaag attcatgtca tctaagaaat gtgatgcata 2393581 cgtcacttga gccccgccag cttcttaaaa gcatcaaagg ggcggaattc aaagaaatgg 2393641 agaaagcaga cagctgctgc gggtcagcgg gaatttacaa catcgtcgaa gttgaaatgt 2393701 ctatgaaaat actggacagc aaaatggctg ccgtcaaagc aaccgaagcg atcctcattg 2393761 taacagcaaa tcctggctgc ctgctgcaga tgaagctcgg cattgaacgc gaaggactaa 2393821 gcggtaaagt cagagccgtt cacctggctg atttgctatt agaagcagcc gggcacaaaa 2393881 catcatgaga aagcccaaaa cagacattgt tttgggcttt tgtgcgttat tccatcggac 2393941 tgcaaatttc gatataatgt ccatccggat cagcgatata ggcgaccgtc tgcccccatg 2394001 gtttcacttt cggctccccg ataatcgata cgccttgttc tctcatcctt ttgatgaccg 2394061 cttctacatt ttcagtaaca aacccgattt caaatgtgtt tgaagcagat gtatccggaa 2394121 tgtccagcgc cgtgatgtct ctggcgcttt cccgggtatt aagcgccaat atcgtagacc 2394181 ctgtatcaaa ttcgacatac gtgccgtgtt cagcacgaat cggcagtcct aaaatatccc 2394241 ggtaaaaaat gaatagcccg cttgctgtcc gatacgtata gaataagata tttcattgat 2394301 agattcattg ccaacccctc tcagcatttt caatagtcct tctagcccgg tatagatgct 2394361 tccatcctta agctcggatc tttccacatc tgcgcccatt ttttcacagc cgccacgata 2394421 atgatgaagc ctaacaccag catgatgata gataatacgc cattcaatac actatatcct 2394481 gctgcttcag gattgagata cacattgcgc accatccaat agcccgcata attgacagtg 2394541 acatataaat aggcaagcgg gataaggcaa gtcagaatgt accggcgttt atcggcgatt 2394601 ttcagcacga tcgtcgctcc gataatcagc cccactgaag ccatcagctg attagaaacg 2394661 ccgaagagcg cccaaatgga accgatatct cctgaataca gcaagtaccc ccacatcaaa 2394721 caggcaagcg cgctggcaaa tacagagccc ggaatccagt ctgttttctt cagcggctta 2394781 tacacctccc cgaagaagtc ctggatcaaa taacgggcga cacgtgtgcc ggcgtcaatc 2394841 gctgttaaaa taaagaccgc ttcaaacata atgacaaatt ggaaaaagta tgaggccaaa 2394901 tggctgaaaa acggcattcc ggtaaaaata taagtcatcc ctaccgcaag cgtgacggct 2394961 ccccctgttc ttccttctaa gtccaaaccg atttccccgc tcaattcagg caaatgtacg 2395021 acattcatgc caagcgtacg gaaaacctca ggcgtgctgt taatcgcaaa gtaatcagca 2395081 ggctgtaaag cggtcgctgc aatcagcgcc atgataccga caagacactc aacaagcatt 2395141 gcgccaaacg caaccggctt catatcactc catttattca gcattttcgg tgtcgttcct 2395201 gagccgacaa aggcatggaa cccagagatc gccccgcagg cgatggttat tgagatgaac 2395261 ggccagacag gtcctgccag caccggccct ccgcctttta cgaattctgt aaacgcaggg 2395321 aacggaatgg acggattgac gacaaacaca ccaacaatca aagcgataaa aacaccgatt 2395381 ttcataaagc tgcttaaata atcacgcgga gccagaagca gccaaacggg aagcgcagcc 2395441 gcaaaaaacg cataaacagg aagcgcgatt gcaagcgttt tcgtatctag cgttaaaaag 2395501 tcaccgagcg cggtagtctg tacccatgga ccgataaaga ctcctgccat taaaaagaga 2395561 aagccgaccg ttgaagcgag ctttaaattt cccgttttct tataaaataa gcccacaccc 2395621 atcgcaatcg gaatcgtaat ccccaccgca aatgttcccc atggattacg ttcaagcgca 2395681 tgcaagacaa ccatcgacag gcccgccatt gtgatcgtga tgataaacag catggacagt 2395741 cctgtacaaa atcctgcaac agggccaagc tcatccttcg ccacttccga cagcgatttt 2395801 ccgtttttgc gcatcgatgc aaacaacacc acaatatcat ggacggctcc cccaattacc 2395861 gccccgatta acagccacaa taatcccggc aaatagccaa actgcgccgc cagaattggt 2395921 ccgaccagcg gcccggccgc tgcgatcgcg gcaaagtggt ggccgaacga aacccattta 2395981 tttgtaggca catagtcttt cccatcctca agcgcatgag caggtgttgg cttgtcatca 2396041 ttcactttga gaaccttcac catcataaat gttccgtata aacgataggc aatagccaaa 2396101 atacacattg atgctatcac aattgtaacc gcattcattt tctcccatcc ccttttctgt 2396161 ttttcataaa tatatcataa tttcatggtg aaaagcggtc attttttcct atacaaaaag 2396221 ccggctggaa tgggccggct cgtggcagtt gaaagacaag ccggagagaa atctccggct 2396281 ttgctattct tatgactgtt ttttcaggcg gatcacattc caggaaagcg gcgtgaaatg 2396341 agcagttaag ccgttttcgc tgacagacga tgatccgttg gaatgcggaa cgacattttt 2396401 tctgttatgc tggtttgttg ctttgatatc ctgatgctca agtacgatgt gctctgcgat 2396461 ttggtaggat tcaaagcctc tgagcgaaat ctccgtctcc atctgatcct cagccttgtt 2396521 taccgcaaaa atagtgagtg tttcttcctc ttcagagtac acaacagcag catcaacata 2396581 tggcacatca gtgaaatcag aacaatcgta cttaggagaa gaaataagcg gtttcagtga 2396641 ctcgcccctt ccgtaaacag aagcatgcat gtatggatag aaaatcggct gtctccatgc 2396701 ttctccgcct ttttccgtca tgatcggcgc gatgacatta acaagctgtg caagacacgc 2396761 aattttcaca cggtctgcgt gctgcagcat cgtaatgagc agagagccga ctaataaggc 2396821 atcttcaaaa ttgtaaatat cctctaaaat cggacgcgca gtgatccacg gctcgacttt 2396881 tttatcagcc tcatttgagt ggtaccagac gttccattca tccagagaga gattgatagt 2396941 tttcttgctg cgtgtttttg cttttacata gtcacaggtc gcagcgactg atttgataaa 2397001 atgatccaaa tccatagaac gtgccaagta gtttggcaga ttgttatccc ggtttccgta 2397061 gtaagtgtga agagagatat agtcgacatg ctcatacgta tgctcaagca ccttcgcttc 2397121 ccaatcgata aaggtcggca taccgctgtt tgagctgccg caggcaacga gttcaattga 2397181 tgggtcaacc cacttcatga cctttgctgt ctctgcggca agccgtccgt attcatcagc 2397241 tgttttgtgg ccgatctgcc atggtccatc catttcgttt cctaagcacc atgttttgat 2397301 gccatacggc tgttcatagc catgcgatct tcttaaatca ctccagtaag agcctttcgg 2397361 atggttgcaa tattcaacga gattacgggc ggcatctatg cctcttgtgc caaggttgac 2397421 ggccatattg acctcagtgt tcaccttttt tgcccaagat aaaaattcat ttgttcccac 2397481 ttcattggtt tctgtcgttt gccatgccaa gtcaagccgt ctcgggcggt tttcgactgg 2397541 tccgacaccg tcctcccagt tgtatccgga taaaaagttt ccgcccggat agcggatgat 2397601 gggaacctgt aattctttga tcagcgactg gacatctttt ctaaatccat cttcatccgc 2397661 ttcagggtga tcaggctcgt atatgccttc atataccgca cgacccatat gttcgataaa 2397721 cgagccataa atccgtttat ctacttcacc gattttatat tctttgtcta caatcattcg 2397781 cgcttttttc atcacacgtt tcctccttca ttaacctttg actcccccta ccgtcaggcc 2397841 ggagataaag tacttttgga aaaacaagaa aatgataatc accggcaaaa tcgcaaatac 2397901 tgagccggat ataagcatgt cgtaattatt tccataaggg ctcagcaagc tggacagccc 2397961 tattggaagc gtaaacattt ctttcgaccg aagcacaatc agcggccaca agaagttgtt 2398021 ccagctgttt aaggactgaa ggataatcat cgcaccgaaa gccggtttca tcagcggtgc 2398081 cataatcctg aaaaagatgc cgaattccgt acagccgtcc atccttgcag agtccagcag 2398141 atctcttgga aggccaagag catattgcct gaaaaagaaa acagcaacag gtgaaacgat 2398201 aaacggcaat atgacacccg tatatgaatc gatcaagtgc agtccgacag taagtttaaa 2398261 cagaggaagc atcatcactt ccagcggaac catcataata atcagcacaa gaacaaagat 2398321 gatatttctg cccttaaaat cataaaccgc aagcccgtac ccgatcatcg aagaaaaaaa 2398381 cagagtgagc acagtcgtaa aaagtccgag tacaagactg ttaaaaaacc atttgaaata 2398441 aatgctgccg ccattaaaca gaaatgtgta gttatcaaaa ctcatcactt ttggatcaat 2398501 atcaagattc agccccacac gcaaaagctc agatgacggc tttaatgatc ctaaaagcaa 2398561 acagaaaatc ggaaaaagat acaataggct cagcatcata aaaaacaggg tcagcgcaat 2398621 tctataaacg ctaaactgag gactgtgccg caacatttat ccctccccct taaacgagcc 2398681 tgacagcttt aatgaaatca ggctgacaac aaggatcaca atcaaaagca caatgccgat 2398741 ggccgctccg tatcccattt cattgtaggc aagtccctgc tgatacaaat atccgacaag 2398801 cgtcagacca atattacccg gggaattatt ctgccaaagg acgtagcttt cctcaaacat 2398861 cctgaagccg ccgatgatgc tgatggtcag cacatatacg gttacaggct tgagaaacgg 2398921 cagcgtgatg tgcagaaatt ttttcattgt attcgcgccg tctatatcag cggcttcgta 2398981 cagctctttc ggcacatttt gcaaacctgc taaaaagtaa aggatgttga ttcccatcca 2399041 tctccatgaa gcaagcagca ccatcaaaaa catgccggta tgttcattgt tcatccagtt 2399101 ctgaggtgaa aagccgagtt taagtaggat ggaattggcc agagacgttt ccatttctcc 2399161 gaagatcagc cgaaaaatga tccccgcgac aatggttgag gtcaatgccg ggataaataa 2399221 tgctgattta aatatatttc taaatttgac cagctttgaa ttcaggaata tggccagaag 2399281 caatggaaca ggaatcagca cgatcagcgt ccaaaaggtg tattccagcg tattccaaag 2399341 ggcggtatag aacgtcgggt tgtttagcgc tgtataatta gacaatccga caaaggacac 2399401 ctctcccggc aaaattcttt ggaagctcat gatgaagaca ctaatgatgg ggtatagaaa 2399461 aaatacgaga aaggataaaa cgaatggcgc tgtaaacaga tagggcgccg ctttttttga 2399521 ataaaacaga tctcgccagc ctgattgttt cgcagctgaa ggaacgggat gaaccgttcc 2399581 cgttttcaca ggtttcatga gaacctcccc gctttcactt tttgaatggg attctatttc 2399641 tgtttcagtt cacctgccgc tctgtccaag gcttgtttag gcgttttttg ctgagattta 2399701 agcgcgtcga acaatacgct tctgttgaca aggtctgaag ccttggcaaa atcctcatgt 2399761 aaataaattg gattgatttc atccttgata tcgagcagca cagaaaaaat gcctgttccg 2399821 ttttggaagt aatccgtgta tttgtttttc tctttcaatt ccttggagct ccaaacatcc 2399881 cagcgaagcg ggtcaaagcc gagtacgctc cagagttttt tatttccttc ttcagagccc 2399941 ttcgcaaagg ccaaaaactc ttttgctaac tcaacatgct tggattgctt cggtacaaca 2400001 gttgccgtac cgcccaaacc tgccgagcgg tcgcccccct ctttccatgc cgggagcggt 2400061 ctgatggcaa tcttcccttt cagatcaggc atataatcga taaatcttcc catataccaa 2400121 atcggcatga gaactgaagc agctcctcct tggttcataa agccgtagta ttcttcactg 2400181 tgatgcccgc cgcccggcgc aggaatcatc gttttatcat tgatcatgtc ttttaaatat 2400241 tgaagtgttt ttacgttggt gtcattattg aggatcagct tgccgttttt atcaaaatag 2400301 cctgagtttt gctgtgaaat catagataag aacgttgcgg aatcatttgt ttccaccgtt 2400361 cccatcggct tcccggtcac tttgcgcact ttctgtccgg ctttatggta atcatcccat 2400421 gttttaatat cgtcaggatt gacgccggct tttttcatca catccatgtt ataaaacatg 2400481 accgttgtcc ctacatgtgt atcgagtccg taaagctttc cgtttttgct gtacaatgtc 2400541 agccgcgcct caacgaattt atcgcgatcc ttttcaatca gcggagtcaa gtcggcaagc 2400601 ggtatgtcag agcccttcaa aaagtttgaa aaacgggcca attcgacatc tgcaatatca 2400661 ggaacgcctt ctcccgctat tagggagata gataagttat cgtgcatttg tccatatgga 2400721 taaacgaccg tattcagctt aattttgcgg tcaggatatt ttttgttcca ttccttcacc 2400781 atttccacat agaactgctc atgaagcccg ttaaatgtcc aaaaggtcag ctcagtttca 2400841 cccgatttgc cggatgattt ttctgctgaa cacccggcaa tgactaatgt cagcaacatc 2400901 atgagcacaa gaaaacagac agtcattttt ttcatctgcg ttaccccttc cattcgaggt 2400961 gcgggctatt catatagacc atggttgatc agcgttttgt tttcattgat gattcttaat 2401021 ccggtgcatc ggtctcttaa ggtgtgcgcg tgtctgaagg catttttgac ggaatcctgc 2401081 ccgacaccga tttcgtcaaa atacgcaggg cctccggctg atctcagcca atcagccagc 2401141 acttctcctc tcgggagtgt ttgataagcc gattggatgg cttcccggcg gcttggtgaa 2401201 aattcgttca gcccgtcatc ctgagcgagc tttctgtatg tgtcagttaa taaaacagcg 2401261 gcacagccca cctttgcccc atgaagaatc tgaggccgtt ttttctccat taactccatt 2401321 tcaatccaat gtgaaatatg atgctcgccg cctgatgccg gtcgggaatg atctaatgcc 2401381 agcatgacaa gccccgatac aagtaaagac tccatcaaaa cccgtatgcc agtttccgtt 2401441 ttcatcgcaa tgtcttctgt gtgttcaatg caggcagcaa gcgcctcctg aacgatctta 2401501 gctcctgcag gcgaataagg ctcaccggca agatgccggg atatttccca atctgctaaa 2401561 gacgtgattt taccgagcat gtcaccaaag ccagccgcca ccattgactg cggtgccgct 2401621 tttaatagat ccagatcagc gaacagcgca gatggggcct tcgtttgaat ggttgttttc 2401681 gtgccgtata aaataatcgg cgcaccggct gatgtaaaac cgtctacaga tggagcagtc 2401741 ggataagaaa taaacggcaa atctctttga aacgccgcaa agcggacgat atcatgaatc 2401801 gtgcccgaac cgactgcgat catgacatcc gttggttgtt tcgtatggat cagcacatga 2401861 atgagcgatc gttcatcagc tgtcacatct ccggcttcat tttctggaat gatcaggcac 2401921 tcggcctgaa atccttcttg attcagtcgg ttttctaaat caattcctgc aatgcggtgt 2401981 gtattcgcgt cgcagacaag gacaatatgt tgattgtttt ttcgttttac ataatccaaa 2402041 agcgaatcag ctgcttgctt accgagaaca atttcttcaa cttttatagg caacgtcttt 2402101 tctccggcgt tttcaaaagc acgctgaacg tcagctgcga tacgattcat atcagaatcc 2402161 cctcctcagc caatttggtt acatccttaa tagaatccag cacataatcc ggcgtgtaca 2402221 aacgctgttc accctgtttc gcagaaccag ttagcactaa ggcgcttttc atgccataaa 2402281 gcttccccat cgcaatgtca gattcaatgc tgtctcctat aatcatgcat tcatgtgcgg 2402341 acagccccat tgctgtacag gcagcctccg ccatcagcca tgacggtttt ccgacaacaa 2402401 gttcagtctt cgcttgtgca gaagtctcaa ttgccccgat cattccggcc acatcaatgg 2402461 catttccgtc ttcgttcgga aaagagcggt ctttgtttgt agcgataata cgagcgccgc 2402521 cggcagccgc ttgaaaggct tgatttaaat cgtcgtacgt gagcgtttca tgaagggaga 2402581 tcacgagcca atccgcttcc ttcggttcgc tcgcgttctg cacaccggcc agcctcagct 2402641 cgtcaaccaa gccttgctcc ccaagcaccc atacctttga aaaacgataa tgttttttca 2402701 gaaaagccgc tgtcacgctt gatgacagaa caatgtcgtt tacgtccgtt tcaatccccg 2402761 cgccaagaag tttttttctg cacatggcac gggagatatt cccccggttg cttaaaaaga 2402821 cgattttctt tcccattctc ctaagcgttt tgatcgcttc tcttgctcct tcgatcaact 2402881 catttcctct gaatacagta ccgtccaagt caatcagaat gccagccggt gacacaggcg 2402941 tatcatgact ggccataata cgcatttgct ccgtgttttc gataaaaatg cttttcatgc 2403001 aggactgtat tgattggggt tacatccttg ttcagcataa tggagtgata ggccatttcg 2403061 gcaaccgttt ctaatacaac tgcgttatga atggcattta aggcgtcagt gccccagcag 2403121 aacggtccgt gattattcac gagcacaccc ggcacctgtt cgtaattatg atgctgaaag 2403181 gtttccgcta tgacttttcc tgtattcagt tcgtagtcat gaatgatttc ttcatcgtac 2403241 atttctcgag tacatggaat cgcactgtca aaataatcag catgggtcgt gcctaacgga 2403301 gggatgtctc tgcccgattg cgcccagctt gtcgcccatt gagaatgggt atggacaatt 2403361 cccccgatat tcggaaaggc tttatataga taaacatggg taggtgtatc tgaagaaggt 2403421 ttaagcgagc cttcgacgac ctctccatca aggttcaaaa caaccaagtc atcggctgtc 2403481 aggtcgctgt attcgactcc gctaggtttg atgacaattc tttctttttc acggtcaatg 2403541 ccgctgacat ttccccacgt aaaggttacc agctgatgct cttgaagctt caggttggca 2403601 gccagcactt ctttttttaa tgtttcaagc atgctccatc accctttatc aattcttttt 2403661 ggcggcagat gaaaattgaa gatttttgat cgttttcaga cgcttcatga catggttttc 2403721 ttttccgaaa taatgaacca gctctttata ttcagcgtac aatttttcat aaaccgcggc 2403781 gttttcggca tttggcgtat aagttatatc tttcagtttt cccatgttcg ccgctgcctt 2403841 tttgatatca tcgtagccgc ctttttcttt gcctgctgca agcgcgccga aaatggcaga 2403901 tcctaaggct ggggcttgcg gtgaaccaga gattttaatg tccatgtttg tcacatccgc 2403961 ataaatctgc atgacaaacg ggtttttctc agctattccg ccggctgcga acagttcctc 2404021 aatcggaaca ccgctttctt tgaatgtttc gataatcatc cgggttccgt aagctgtcgc 2404081 ttcaactaac gctctataaa tctcttcagg cttcgtcagc agtgtcatgc caagcagcat 2404141 ccctgttaaa tctgcatcaa caagagttga acggtttcca ttccaccaat ctaaagcaag 2404201 caagccgctt tcaccaggcg cttgatggtt tgctttctca ctcagcagct catgaacgcc 2404261 aatgtttttt tcctttgctt cctcttgata agctggcggg acacatgttt tcacaaacca 2404321 gtcaaaatga tcgccgacac aggactgccc ggcttcatat cccgcatagc ccgggagaat 2404381 tccgttgtcc acaacgccgc acattcctgg aacgatatgc acctcttcac caagtagaac 2404441 atggcacgtc gaggttccca taatcatcag cattttccct ggctctgtaa tgccgaccgc 2404501 cggtaccgaa acatgagcgt ccacattggc aaccgcaaca gccgttcccg ggagaagccc 2404561 tgtcagcttt gccatttttt cagtcagact gccggctttt tctcctactg aatgaataga 2404621 acctgacaat ttgtcctttg taatcgtttt cattgaagga tttaatttct caaagaaatc 2404681 atctgacgga taccccgctt tttcactcca catcgcttta taccctgcgg tacaattgct 2404741 tcgcttgagc gagccgcaca gctggtacac gatccagtcc gcagcctcga tgatccggtc 2404801 agccgcttca taaatgtgag gcgcttcctc ggcaatttgc atgacctttg gaatcatcca 2404861 ttctgatgaa atttttcctc cgtaccgctg taaaaaagcc tctccttctt cttccgcgat 2404921 ttgattgagc cgatcagcat gtttttgggc cgcatgatgc ttccagagct tcacatagct 2404981 gtgcggctcc tcttcatatt caggcagcat gcataacggc tgcccgctgc tgtcaatagg 2405041 aaggatcgta catgccgtga aatcaattcc aatcccgata atgtctttcg ggtcaacgcc 2405101 cgtctgttcg agtaaagacg gaatggttgt ttccaagact tcgaggtaat cagcagggtg 2405161 ctgcagcgcc cagtcacgcg gcagcttttg acccgttttt ggaaggacgg tatcaatgac 2405221 agcatgcctg tattctttta cagcagccgc aagttcctcc cctgtttgga catgaacgag 2405281 cactgctctt cctgataaag ttccaaaatc aacccctatt gtgtaagcca tgtgacatcc 2405341 ccctctactt ttgaagccgg taaagcgcct cgttccattt taactcgtgt ttcagtttat 2405401 gaattgtcgt atcacgggaa atgagaacac tttcgattcc cgccatttcc gcccaatcaa 2405461 gcatttgctc cgctgtcagt tcataagaca ggcaggtatg gtgtgcaccg ccggctaaaa 2405521 tccatgcctc cgctgctgtt ttcaatgacg gctccggctt ccagagaaca cgggcaaccg 2405581 gtaaattcgg catgtctttt tcaatttcct ggccgttgac ttcattcagc acaaggcgga 2405641 aacgcccgcc aatatcaaca atgctagctt gaatggcaga accgctgatg ccgttaaata 2405701 ccaaacgcgc agggtcctct ttgccgccaa tcgaaagcga atgaacctcg attttcggct 2405761 gatccaaagc gacagtcgga cacacttcaa gcatgtgaga gcccagaatc atttcatttc 2405821 ccggttcaaa atggtacgtg taatcttcca tgaaggaagt tctttttcct ttagccatga 2405881 ttttcatcat ccgtacaagg gccgctgtct tccaatctcc ttcaccggca aacccatagc 2405941 ctttctccat caggcgctga acggcaagtc ccggcagctg tttcattccg tgcagcactt 2406001 caaacgatgt cgtaaacgct gtgtatccgc cttgctcaag aaaagcggtt aatccaagtt 2406061 caattttcgc ctgttcttta atggacgcta cctttgcttc gtcacgtttt gtttcctcac 2406121 tgatcacata tagtctgtca tactcggcat aaagcgtgtc aacctcgtcg tccgtaatgc 2406181 gatccatcac ttcaacgaga tccccgatgc catatccgtc aacctgccag ccaaattgaa 2406241 tatgcgctcc caccttgtct ccgtccgtta ccgcgacatg acgcatgtta tctccaaatc 2406301 tggcaacctt aatatgtctg ctttcattta atgcagccgc cgtatccatc cactgggaca 2406361 tttctttttt cacttcttca tcatcccaat agccggcaat gacttttcgg ctaagcccca 2406421 ttctcgagtt gatgtaaccg tactctcgat cgccatgcgc ggattggttg ctgttcataa 2406481 aatccatgtc aatcgtaccc cacgggatat cgcgattata ttgggtatgc aaatgcataa 2406541 gcggtttttg ataagaggaa aggccttcta tccacatttt tgcaggggaa aatgtgtgca 2406601 tccatgtaat gatgccagca catgtctcac tgtactccgc ttctcttaac agctctctaa 2406661 tggtttccgg tgaagtgacg acgggcttat gagtgatttt atatctggaa gaaatcccgc 2406721 tgagcccctc acaaatgctt ttagcatgct gatctacgag ttccagcgtc tcttccccgt 2406781 ataggtgctg gcttcctgtc acaaaccaga attcataatc ctttgtctga agcatgtaaa 2406841 ctgccccttt ctcataaaat aaaacgcttt caaatacaaa agatacgtac taatgataga 2406901 aaataaacct ataaataaat atttgtacga acaattttat tatagtaatt gactattata 2406961 ctgtcaatct tttcttttaa aaaaagccgg gggcagagcc cggcttttta attcaatagg 2407021 acggccagcc cgagctccaa ttcaaatcat tgatgagaag ctttggaatg ccgttgtcat 2407081 tggcatcata ggcatggcga acaagaatgt ttccgttcac aatatcctgg cctccaggtc 2407141 ctttccattg gtcattgccc gaatccaaaa tggtgcctcc gccttcaagc atgctttttc 2407201 cgcttttatc aagataaggg cctgtaatgc ttttggatct tccgtaagca attttgtacg 2407261 tactgtttac cccgtcacag catttatcaa atgaaaccat taaatagtaa tatccatttt 2407321 gatacgtaag agtaggagct tctaaggcac ctccattatt cggtctagct gcaatcgaat 2407381 agagcgagcc tgtaggcttc attgtactct tatcgagctt agtcagctta atgccgctcc 2407441 aaaacgagcc gaatgcaagc cacgggttgc catccttatc gaatgtcagc tccggatcaa 2407501 tggcgttata attatttgag cttgtcgaac ggatcaccaa gccctcgtcc ttccagcccc 2407561 ccgaactgat gcttgttgaa gatgccaggc caatggcaga tgtattgctt ccaaaagaag 2407621 aaacggaata atatagccag tacttgccgt tatagtattg gatgtccggc gcccactggt 2407681 tttggccata attcggcaca taattggacc accacgatag cggtgtagtg aaaatggatt 2407741 tttgtacggt ccaattttta gcgtctgaag acttcaaaac ccgcagtccc cgttcttcag 2407801 taagccctgt tccgagcgca taccatgagc tcccctcttt aatcatagtc gggtcatgaa 2407861 gcagctcatt ggatgcaccc caaaacgctg cctctgcggg agcagcagaa gtgaatatca 2407921 aacctgcagc cagagctgca ctcgaaaagt gtaagaagcg tttccatgtt tttttctttt 2407981 tcaattttgt tcaacctcct ttattttaga aagcgcttac aaattagatt atttatcctc 2408041 ccttcctgtc aaatcgactg cgtatcgtat atcgtcatgt tcaggaaatt ttcggtatcc 2408101 cctttattgt agtcactatg ctgtaatttg tacagacaaa aaaatagaat ccacctcaat 2408161 aggcggattc ttccgtatct ttattggtac gtaatttcgt caaccgtttt tcggtctaac 2408221 ttcttaatga cttctgtaat taactttacc gcgttttcat aatcatcacg atgcagcatg 2408281 gccgcgtgcg tatgaatgta gcgggttgca atggtaatgg acagcgcagg aacgccattt 2408341 gccgtcaaat ggatggcacc cgaatcagtt ccgccgccgg caatggcatc aaattggtac 2408401 ggaatgccgg cttcctccgc agtggctaca actgcatcgc gcaaaccttt gtgagagacc 2408461 atggatgcat cgtaaacgat aatctgcggg cctttgccca ttttgctctg cgcttccttc 2408521 tcggaaatgc caggcgtgtc tcctgctatc cctacatcaa caccaaacgc aatatcaggc 2408581 tgaatggtgt gtgcagccgt tttcgctccc ctcagcccga cttcctcctg cacggttccg 2408641 acgccataca ctatatttgg atgatctgtg ttttgtaagt ttcttaacac atcaatagca 2408701 atcgcacagc cgatgcggtt gtcccaggcc tttgcgagta ggaatttttc attgttcatg 2408761 accgtaaatt caaaatgcgg aacgatcata tctcccggaa gtacacccca ctccaaggct 2408821 tcttcccggc ttgaagctcc aatatcaata aacatgtctt ttatttccac tgattttttt 2408881 cttgcttcag gagacaaaat atgaggcggc ttagatccga taacccctgt gatttctcct 2408941 ttttttgtga caatggtgac gcgctgagca agcataacct gagcccacca gccgccaacg 2409001 gtttgaaaac ggataaagcc tttatctgtg atttgtgtca ccataaagcc gacttcatcc 2409061 aaatgtccgg cgatcataat tttcgggccg ttttctgcac cagttttttt tgcaattaaa 2409121 ctgcccaggc gatctgttgt cacctcatca gcaaatggtt ctatgtatga tttcatcact 2409181 tgccttactt ctctttcatt gcccggtatg ccttttgcat ctgttaaatc tttcagcatg 2409241 gtcaatgttt catctaattt tgccatgttc caaaccctcc ttcatcagtc ctgcattctt 2409301 attatacaaa acatggcgct aaccatacga ctatttcact tgaaaatcgg gtatatgttt 2409361 ttacagcttt cttttagaaa aagtgaaacc tttttctatg cttttcgtat tacatcagat 2409421 catcaccata agggaggtgc cttcacacaa tgtttgtcat ggttctaagg attattttgc 2409481 ttgcactttt tgcttattgt atttatgccg tggtcaaata tgtcgcgaat cctaagagaa 2409541 ggcttaagct ggcccaatca aaagaacatt tttatattat tgatgaacaa aacaataccc 2409601 ggaagaattt tcagctgacg tataaaggcg tgctttttga gggagaaaag catattcctt 2409661 ccaaggatca tccgctgttt attcacacga tctttgtctg gacagaatct cctgagaagc 2409721 tgaaacattt ctctgcaaaa gattttgaga acattgaaga aaaagtgctg gaacgatatc 2409781 caaattgtaa gattgactgg gaccagccca ttaaactcgc aaaaaaagca gaagagcgtt 2409841 aaacgctttt ctgcttttta taaatcaaac gggctgtagt aaatagcgat gagaatcgct 2409901 tctattacca gaagaagcgg tactccgtac ttaaaagaag cgtgtttcgt tttatgtctg 2409961 aaggtttgca tgccaagcca gacaccgagc gctccaaaca cgatggctat cagccacagc 2410021 cggtcttcag aaattctcca cttgtgctgc tgcgctttgc gtttgtcaat gcccatcacc 2410081 caaaaaccgc acagattaat caacaccaaa taagcagcaa taatcatgtt gcctcatcct 2410141 ttatatagaa aaagccgctc tgctggagag cggctctata tgattacttg tttaattgag 2410201 ctttagcagc atcagcaagc tgattgaatg cagtaagatc gtttacagca agatcagcaa 2410261 gcattttacg gtttacttcg ataccagaaa gcttaagacc gtgcattaaa cggctgtaag 2410321 aaaggccgtt catgcgagca gctgcgttga tacgagtgat ccaaagttta cggaaatcac 2410381 gttttttctg acgacggtca cggaaagcat agtttccaga tttcatgacc tgctggttag 2410441 ctactttgta taatgtatgt tttgaaccga aataaccttt tgctaattta agaacctttt 2410501 tacgacgctt acgtgtaaca gttccgcctt ttactcttgg cattgaattt ccctcctaat 2410561 tgttccttat ccgattactt gatgttagca agcatttgtt tgatacgttt gaagtctcct 2410621 gcgcttacaa cagcactctt gcgaagctta cgcttttgct tttgagattt gttggcgaat 2410681 aagtgacttg tgtacgcgtg agaacgtttt aacttcccag aacctgtctt tttaaaacgt 2410741 ttagcagatc cgcggtgagt tttcattttt ggcatgggat ttcctcctta ttgcttttcg 2410801 tttttcggtg cgagcattaa gaacatgctg cggccgtcca tttttggttt tgtttcgact 2410861 gtcgcaacct cagcacatgc ttcggagaaa cggtctaata cacgctgacc gatttcttta 2410921 tgagtgattg cgcgtccttt aaagcggata gaagctttca ctttatcgcc tttttcaagg 2410981 aatttaatcg cattgcgcaa tttcgtgtta aagtcatgct catcgattgt cggacttaac 2411041 cgaacttctt ttaagttaat gattttttga ttcttgcgtg cttctttttc ctttttctgc 2411101 tgctcaaatc ggaacttacc gtagtccatg attcggcaga caggcggttt tgcattcgct 2411161 gcaactaaca caaggtcaag atttgcgcgg ccggcgattt caagtgcttc ctgacgggac 2411221 ttgattccaa gctggtcgcc attttgtccg attaaacgga cctcacgtgc acggataccc 2411281 tcattaacca attgatcttt gctaataatg agccacctcc atagtttctt cgaattgatt 2411341 cacaactcat tttgaatgca ttttgcaggc aaacaaaaag tgtgggcatt ataaaacacc 2411401 cacactacga acatctgtat caataaaaat gtacggtcaa cctgccaact acatgcatgt 2411461 gtcaatcagg tgagaagcgg gtgcttctgc ttgtgattta tattcaattc aataactatt 2411521 ctacacaata ccggatcttt agtcaaggac gacttatccg gaacaacttt tacattgtaa 2411581 catgggtttt ctatgagcgc aagagagaaa aagaaaatct ttcatcccca cccagaatac 2411641 aaagaaccaa caattccccc ttattacgca atttacaaca aaaccaccga caggaagaaa 2411701 tgtaaaacaa agttaatctc tgaccgatat aaggagcaga agggagcctg acacatgaac 2411761 aaactgatac agcttgcttt atttttcaca ttgatgttaa ccggttgctc gaatagcagc 2411821 acatcttccg aatcaaaagt cgaaaccact gttaagacaa cggcagcatt tcctcaaaag 2411881 gagctggaga aagagctaaa aaaactaaaa cccgtttcat tggacatgaa gttcgagagt 2411941 ccactcgcta ccgagttagg aaagcggaag gcaaaagagg aagctgaaaa gcaaagacaa 2412001 atcgccgctg agaaaaagct tgaaaaagag cgggaggcga aacgaaagaa acagcaggag 2412061 gaaaaagcgg agagacagcg attagcagag cagcaggctg cagagagaca gcgattagcc 2412121 gaagcggaaa gacaagctga acttgaaaga cagcggcagg cagcaatcca aaaagagcag 2412181 aaagcgaacg ctgagaaaaa gcggcaatcg caggcacaac ggcagcagac tgaggcaccc 2412241 tcatctaata gtcaagatcc accatcttcc tcgagtcaga cagataaaac cattcaacag 2412301 ccagcttcag agcttcctga tgacgatggt tatggttatg aagaacgaaa aaagtggcat 2412361 gacgatcaag tagaatgggg cattaaacaa gggtatatcg atcccgaaga cgcaccataa 2412421 aataaaaaaa gccaaggcat tcagccttgg cttatcctcc gatcagctgc acgaacacag 2412481 ggatgaccag aaccgttacc actcctacta cgacaacagc aatacttgcc atcgcagctt 2412541 caacttctcc catctcaatc ccgaccgcta caccaagtgc atgtccggat gttccaagag 2412601 ccaatccttt agaaatcgga tttttcactt taaacacctt caagaacaat gctccgagcg 2412661 catatacgat gacagcgtta aagatgaccg caaaggctgt gatgtcgctg atgcccccga 2412721 tgccttttga taaaggaagc gcaattgccg ttgtagccgc ctgcggaagc atgcttttca 2412781 ttacggccga atcgagatga atgcctttag cgagcagata aacaatcgtg acagagcaga 2412841 tagagccggc aataatggag gccatgattt gccaccagta ctttttaagc ttatctcttt 2412901 gtttgtacaa aggaattgca aatgcgatcg ttgccggttc aagaaaaaac ttaatgatct 2412961 ctcccccgtt attataatcc gcgtaggaaa aaccgccgat ttttaaaaat gcgatcccca 2413021 gcaccatggc aacaaacaaa ggagtgaaaa ggaagaagcc tttcgttttc ttaaataaaa 2413081 aggtgccgat gccgaatgca gcaagtgata cgacaatccc aaaataagga ctcattgtgc 2413141 tttccatgtg aagaacctcc tgtttccctt aatggtgaac gagttcgtta ttgttctgcg 2413201 ggctttgcac tgtttttgtt ttcatgtccg cttcggtttt gcgttttccg ctcagcgaca 2413261 gaatcagctg agaaaacaat cccgtagccc ccagcaaaat aatcgttgcg agcagaatga 2413321 caagaacaat ttgcaggccg tattgctgca tcacaccaag cgaattcata acagatatac 2413381 ctgatggaac aaataaaaat ccgatcagag aggttaaaga cgttccgagc gtctccactt 2413441 gttccagttt aatgactttc aaacataata ggagaaataa taagaccaac cctacaaccg 2413501 atgccgggat aggtattggg acaatagcgg caatcatatt tgaaaccagc ataatgacgg 2413561 caaaaataaa tgcttgtgtt aaaaacccgt acactttttt agcactcatt ttcttcacct 2413621 ctttctcttt ggtaccctca ttataaataa gaattccctg ttataaagcg cttacaagat 2413681 aacatgccgt atagcgggtc tgagttgcag aatcaaatgg ctgaaatgca aaaagccgcc 2413741 catcaaatat ggagcagctt tttcaattcc ttcgcatatg tccggctgac cggtattttc 2413801 gatccgtctt tcatgatcag attatacgtt gaattaaacc atggctgaat ttctttaata 2413861 tattcagtat tcacgacaaa gctccgatgg acgcggataa aatcagaatc cggcagcttt 2413921 ttctcaatca caacgagtgt atcgctgacc gtataagaat gatcgaaggt ttttacattg 2413981 acatgaccat cttctgttcc ggcatagata atgtccttcg tatccacaat cacaatcgat 2414041 tcccccacag atagcgcgag cttgtgctgg ccggcatggc tgttttgctc tgtttctaca 2414101 atatcccgat tgactttttt atattttttc agcgtttgct gaattctttc ttcatcgaaa 2414161 ggcttggtta aataatcaag agcgtccacc tcaaacgctt tgagcgcata ctggtcatac 2414221 gctgtcgcaa acacaatagc aggaggatgc ttcattttct tcaatcgctt tgcgatatca 2414281 aaaccgtttt ctccggataa atcaacgtct aaaaacagca aatcaggttt ttgatccatc 2414341 atttggtcaa aagcggattc gatattttcc gcttcattga tttccatttc atcattggtc 2414401 cgcttaagca agtaagccag ttcatccctt gccagcatct catcatcaac tattaacacc 2414461 ctgagcatgt tcttctccct ctttcatctg ttgcattggc acttgaaagg aaacctctgt 2414521 ccctttatga acctcactgc tgatatgcag tgcagcctgc tgtccgaata aaccgatcag 2414581 ccgctgattt aggttataaa gcgctgtacc ggttccctcc ttagacggaa acggtttctt 2414641 ccccagttcc ggcaagacgt ccggcggaat tccgcgtccg ttatccgcca ccttcatata 2414701 gacggatgca tcatcagata agacacagac tgtaaccttg catatgtctt gttttttcgg 2414761 aaacgcgtgc cgaagcgcgt tctcgacaag cacctgcaaa acaaacggag ggatttcaat 2414821 ctgctccagt ctgctgtcga tattaagctc aattttatat ttcccgggaa aacgcgcctg 2414881 ttctaatgac aaataggcgt taagatggtt cagctccttt gagagcggaa tcagcagctg 2414941 tctcgctcct tgaaggtttg aacgaaaata aacactgagc tgcaatagga gcttacgggt 2415001 tttttcaaca tctgtacggc ataacgcaga aatcgtgttg atcgcattaa ataaaaaatg 2415061 cggattcacc tgtgcttgaa gcgctttaat ttcagcatcc ttgagaagtt tgctttgcag 2415121 ctctgcttcc ccaagctcaa gctgtgtcga aaacagcatg gccagcccct cggcaagttc 2415181 ctcctctacc tgactcaggc ctgccgggct tttaaagtac atttttaagg tgccgattgt 2415241 attgccgttc gatgtcagcg gtaggacaat tgcagcgtgc aaagggcatt cagcatgcgt 2415301 gcattcaatc tcttcctgcg aaatcgcctt cataatatgc cctgttttaa tcaccttttt 2415361 ggacaggccg gtgatcaagc ttttcgatgg gatgtggtga tccattcccg caccgacatg 2415421 cgcaaggatc ttttctttgt cagtgagaga caccgcatct gttcctgtca gcttatggat 2415481 aatagccgct acacttttac aggagttttc atttaatcct tggcggaaaa atggaagtgt 2415541 ctgatcagca atcgtaagca ctcgatgcgt ttcgagagcc cttgcctgtt cttccttgcg 2415601 aatgatcgct tgaataatag acagaaaaat aaaactgcct gttccattga tgagtatcat 2415661 cggaattccg atcatgctga caagctccca agcgtcactg aacggctttg ccatcagcaa 2415721 aataatgatc atttgcagtg actccatgcc gattcccaca agagcggcga tgcgcggtgt 2415781 cggcattcga tatcgcttcg taaaatacct gccgatcaag cctgcaagaa cacccgctaa 2415841 aatagatgag acggcacagc ttaaggccgt gctgccaccg agtgaaaaac gatgcaggcc 2415901 cgcaagtatg ccgatcccag cccctacaaa aggacctccg agaaggcccc cgatttccac 2415961 gcccaaaata cgggtattcg cgatagagcc cgatggatct atcgtaaaca cccagtcatt 2416021 gtttacaatc atatttcttt gaatttcgat gcctgtataa ttgctgatga tgctgaaaag 2416081 agaaaaaata gaaattaaaa tcgcttttcc tttatagccg tcctgattct gaagagcttg 2416141 tctgaaaagt ttcgtatggg cgagaatgaa ccctaatata acaataatcc ccactctctc 2416201 cagcatcata atcattaaat gaatcattca tgtcacctgt tctttccgtt ttcattctag 2416261 catgttttcg ttttgcggct gactgttttt ttaaaatcgt ctgaaaacat atttcacaag 2416321 gcttttatct attgtaaaat aaaacatgag ccttttggca gaaagatttg aatctgaagc 2416381 agaggagaag atcatgaaag ccgtattttt tgatttagat gatacactac tttgggacga 2416441 aaaaagcgtc agaacaacat ttgcagaaac ttgcttacag gcggagaaaa aatatggcct 2416501 tgcccctgag gaattcgaag cagctgttcg cgaagcggcg agagaattgt acatgtcata 2416561 tgagacgtat ccatatacag tgatgatcgg cattaacccg tttgaaggac tgtggtccaa 2416621 tttctcagag ccaatcagtg aaggctttca aaagctgaac aagattgtgc cggagtacag 2416681 aagaaatgca tggaccaacg gactgaaagc gcttgggatc gatgatcctg catatggcga 2416741 atacttggga gagttttttg cggcagagcg cagaaagcgc ccgtttgtat atgatgaaac 2416801 ttttgctgta ctcgatcaat taaaaggcaa gtatgaatta ttgcttttga caaatggcga 2416861 tcctagtctg caaaaggaga agcttgccgg cgtgcctgag ctcgctcctt acttcaatga 2416921 aatcgtcatc tcgggcgcat tcggcaaggg caagccggat gtttcaattt ttgaacactg 2416981 ccttaagctg atgaatattg aaaaagacga tgccatcatg gtcggcgata atttgaatac 2417041 tgatatttta ggcgcttcaa gagccggaat caaaaccgtt tggatcaacc ggactgataa 2417101 gaaaaacgaa actgacgtaa agcctgatta catcatcagc agccttcatg atttgtttcc 2417161 tatattagag aaataaaaaa agcatgatct cttcaatgag atcatgcttt tttattttat 2417221 tttttcgctt cagctactgc ctttttcaca aactcatcaa gtgaaatggt ttcagagttc 2417281 tgttctccgt atttacgcac gtttaccgct ccgttttctg cttcttggtc accgaccacc 2417341 agcatgtacg ggattttttg catttgcgct tcacggattt tgtagccgat tttttcatcg 2417401 cggctgtcga cttcaacacg caggccttca cattgcaggc gttcctgcac ttttttcgcg 2417461 tagtctaaat gcacagccgg agaaaccggg atgacttgga actgaaccgg tgcaagccat 2417521 gtcggcagcg cgcctttgtg ttcttcgatt aagaaagcaa caaagcgttc cattgttgaa 2417581 acgacacctc tgtgaatgac aaccggacgg tgctgcttgc cgtcctcacc gatgtatgtc 2417641 aggtcgaaac gttccggcaa taagaaatca agctgaaccg tagacagtgt ttcttctttt 2417701 ccgatcgcag ttttcacctg aacatcaagt ttaggtccgt agaatgccgc ttcaccttct 2417761 gcttcgtaat agtcgtggcc gatttcatcc attgcctctt tcagcatgga ttgcgctttg 2417821 ttccacattt catcgtcatc aaaatatttc tctgtatctt ccggatcgcg gtaagacaga 2417881 cggaatgtgt aatcacttaa accgaagtct tcataaacat cctggattaa acggactgta 2417941 cggataaact catccttaat ttgatccggg cgcacaaaga tgtgtgcatc atttaacgtc 2418001 attccgcgta cccgttgaag tcctgacagc gcacctgaca tttcatagcg gtgcatcgtt 2418061 ccaagctctg caatacgaat cggaagctcg cggtaactgt gaatgtcttg tttgtaaatc 2418121 atcatatggt gcggacagtt catcggacgc aatacaagtg tttcattgtc catttccatc 2418181 ggagggaaca tgccttcctg ataatgatcc cagtgtcctg atgtttcata cagctctttg 2418241 ctgcctagca caggtgtgta tacgtgctca tagccgaggc tgatttcttt atcgacaatg 2418301 tagcgctcga tgacgcggcg gattgttgcg ccttttggca gccaaagcgg caggccttgt 2418361 ccgacttttt gagagttcgc gaacagcttt aattctttgc caagctttct gtggtcgcgt 2418421 tctttcgctt cttctagcat acgaagatgc tcttcaagat cagctttttt gaagaaagct 2418481 gtaccatata cgcgctgaag catttggttt ttgctgtcac cgcgccagta tgcgcctgca 2418541 aggcttaaca gcttaaattc tttgattttt ccggttgaag gaacatggac gccgcggcac 2418601 aggtcaaaga attcgccttg ctcatagatc gaaacggttt ctccttcagg aatcgcatcc 2418661 aatagttcaa gcttcaggtc gtcgccgatt tccgcaaaac gggctttcgc ttcttcacgg 2418721 ctgacttctt ttcgaacgat cggaaggttc gcattaacga tttttttcat ttctttctcg 2418781 attttcggca gatcctccgg tgtaatcgct tcgtccattt ctacatcgta gtaaaaaccg 2418841 ttttcgataa ccggaccgac gccgaattta acatccttgt agatgcgttt aatcgcttga 2418901 gccagcaagt gagccgcact gtggcgcata atttgaagac cttcttctga gccttctgta 2418961 atgatttcca ctgtaccgtc ttcattgatc ggcgttctca aatcgatttc ttttccgttc 2419021 agttttccgg ctaatgactt tttctttaat cccggactga tggatgccgc gatatcttct 2419081 gttgttgttc ctttcgcaaa ctccttgact gctccatcag gaaatgtgat ttttaccata 2419141 tctgacatct ttgtcactcc tttttttgca tataaaaacc ccgcccccta tgaaagggac 2419201 gaggttgaat aaacggaatc gtggttccac ccttttttcc gcaaagccaa tacacggcac 2419261 ctgcggctct aagctctgta acgggagttc ccgtcagcca ttactgttcc ttttcaagag 2419321 gttcacagct gaagttcaaa ggcggtaaag cgaatggtcc ttagctggga agcttgcagc 2419381 cagggcttcc ctctctttga gccggtatca ttccttcgtg tccttatcaa tacgtgtgtc 2419441 tttcttaatc tcctatgtat tataaattgt tcaatccaaa aaatcaacac gatcgcgttt 2419501 cctttttttt aaaccgacag ccttaaatag acaggctgcc ggccctcatc cttccgagtg 2419561 cttcaccggt atttctgcat ctgtaaaagc atgcagcggg agcatttcca ctctctcttg 2419621 aaatacgttt tgaatggtcc ttgccatcat gtgctcgggc tggtcggtat aaagcacgac 2419681 ttcatcaggc gcaatggaaa tcagcggcgc gagcaaatga gaatcaatat acataggatg 2419741 atcccggaca aatcttctgt ctatgtattt cattttttcc cgttccggca catagcgcag 2419801 ctcccataat gtaaaggaac catcatggac aatatgcact tttttgattc gcggctgttt 2419861 ggcgtccaca tagtctctga gtgtttgaat aaagttttga tattcctgtt ccatcttata 2419921 ttcatcaatc gctgcttctg taatatctct cagctgctta tagtatgatc caagtcggaa 2419981 ggtctgaaag gagcgaatgt aaaatactcc ttcctctaaa cagatcgttt ggagttcatc 2420041 caaaattgat tgtttccgtg aaagcttcag cggctcaaac ggaagatcgt ctgcttcacc 2420101 ttcaataata ctgtgtgcga gctgaaggat ttgctgctgt tcatcctggt ccgtgaaaca 2420161 atacgtttcc tcaatcaatg acagcatatg ctcgtcttct ttgcattcca aaaaaaattt 2420221 gaccagaatc ggctccataa aacgctgaat aggaaaagcc ggattcgctt tttcaatccc 2420281 gatttttcgt atgccttcac ggacaatgat attgttccga tcgtccgaat gctgaatgag 2420341 atgtaaaaaa gcggctgcat catggtcatc ttcaaagatt atttcaagca tgtttgtccc 2420401 cccttacggc atctgttaca agtatatggg ggatgttttt aaaatagacg taaaggtcat 2420461 tggcaaatct taatttgatt cttggaacaa gttttgcatt ttctttctga agatgaacgg 2420521 caatgagata aacacgatat acaaagcgag caccataaag aaagcgggca gattgccagc 2420581 caaaaagctc gcacccagca cattaagcgc aatcgtccca gggatgattc ccacagccgt 2420641 tgcggcaaaa tacggcagcg ctttgacatt ggaaaggcct gccgcatagc tgacgaaatc 2420701 aaaattgatc ggcaggattc tcaaaagaaa gatatagaaa aatccgttat cctccatttg 2420761 cttctgtatg gcttcaagcc tttcgtaatg cccgttcttt ttcgccgaaa acaaaccagc 2420821 cgcaaaaaac gaaacagctg aagcgcacat cgaaccgaat aacgtataaa gcgtgccgag 2420881 aagcgggcca aacgcaagtc cgccagctat tgaaataaca gacaccggaa ataaaacaag 2420941 tggcctgacg atggatatcc cgataaacat cagaggtgca aagactccga acgacaatac 2421001 ccataccctg atttctttcg gcgatacatt caaatacgtt ttatttcccc aatagagtaa 2421061 accagcacct gcaagcactg ccagccattt gacagccgtt tttcgtttca taccctcagt 2421121 tccttcccct ttgaaccaca gcaattatgg atgtcggcgg ttttctccgt caaggcggat 2421181 cggagcagcc aaatataata tccgctccat taatcttgca gcttttactt cttctttttc 2421241 tcccctctgc gaatacgtaa aatgatgctt cagctcgtca ggtgagaaat tagaagaaaa 2421301 gaacgttggc agctgctggg acattctgtg ctgaagcacc gttccgatga cctcatccct 2421361 tacccagctt gtcattgatt ctgctccgat gtcatcaagc attaatacgg gtgtggtctt 2421421 taccatattg agcttctctt ccaatgtctg gtcttgcagc gaattcttaa gctctctcac 2421481 aaattcaggc acataaacaa tcatggagga atactctttt tccgccagct cattggcaat 2421541 tgcagcgagc ataaacgttt ttcctacccc aaatttcccg tataaatata atcctttccc 2421601 ttttcccgtc tcattatagc ttttcaggaa gtctgtaaca tgctgaaaca tcgcgagtct 2421661 gcttgggtca ctgatatcaa cttgctggaa cgtcgctcca agaagatcct gctggatata 2421721 catgcttttc ataagagact gttgtttctt ctgctggtcg agcttccgtt tgactggaca 2421781 ttcgtaatac tcgatatcaa tagacctccc attgacaaca agcttcggat ggtagccctc 2421841 caacaaattg ttgcagtttt catcttccga acaataggag caattcttgc tttgttcgat 2421901 atattcataa agcttattta agctcttttc gatcattttt tggtcaatca cttcttcgtt 2421961 ttccttcaaa aatgcttgaa catcttgatc tttcatgact ttttccttca tttgttcaag 2422021 acgtttttgg aaatccggcc tgccggttac gccctgcagg gaacggccga ttggttccat 2422081 ctattccttc accccgcatc tctgtcttta ataggcagag tattttttca gtttttgcat 2422141 ttcttccatc atctttttct tctgttcttc caaatcctgc ggatgcagct tctgctgtcc 2422201 ggattctgaa tcggacgctg tttccttttc tgtcatccaa tcaggaagct tttcttcacg 2422261 aatcactttt tggtttcgtt tcgaagactt tgtttttccc tcagcccatt caagatactg 2422321 gcggttttct tctattgcga gcttcatcgc ttccctgacc gttttcacct ttttgcgtgc 2422381 ccaatgcgaa gcgatttttt ggatatagtt tttcgacagc ttcatgtcgg ttttcagcat 2422441 gacataataa attaacacat ttgtgacgcc tggctcgagc ttctgttcga acataatttc 2422501 ttctatgatc ttcagatcag cttttgacgg ctctgttccg tcagcaatgt cctgcagaag 2422561 cttcttcggg gaaatcgcct ccagcaatgc aatcagcttc ccatccagag aatcctcttc 2422621 tgccggttgt tcgccttcac gcagatgcac cggctgtgtt ttttccacca aatcgggcag 2422681 ctgtccgttt ctttcaattt gataccagtc gctcgccgct tttcttaatg cctccgtcgt 2422741 aatgacgtca cgctcatcaa ttgcgctcat cacaacattt tgcatttgca aagggtcaat 2422801 tccgtacaga taagaaagct ttttgattgt gtcccgcacc tgctgggtca tcgcttttct 2422861 cggtatcatc gtctcagaaa gtcccgctaa aaacaaatca aaatcaaaca catcctccgt 2422921 tatggtgtag gacggagact gtccgacaga agtatactcg gacccctcgg caagccttac 2422981 cgtttcctcc atatcggatg tgagcttcca ttcactcggc tgcagcgatt caaacgcatg 2423041 attaaacgga cgcgtaatgt ccttcgcatc ttctgaaatg gccgggtgcg taaaaaattg 2423101 ttttaattgc tgatatttcg tttttccgac cctattatac agaaaaacat tcagcattcc 2423161 gtcttcaaaa aattcatttg gtctgagcgg cggaaggagt tcatatataa agaggcgctc 2423221 ctgccgctcg gattctttca tatatacttt cagcaatccg atgccctcga gcttcccctg 2423281 ttcctgatgg atcgttttta agttggactg tgtcatcccc atcagctgtc tatgtgtgga 2423341 ctctccgccc cacagacggt tttgttcaag ctctccccac aatgtcatat aaagagagaa 2423401 tgcaacaggg ccgattaagg gctggtacag ttgtgtaata atttgtctgt caatatcctg 2423461 cagcatcgat ctgcttttaa ccacatacgg gtctacaggc agtacatctt tccaatagtc 2423521 agccatacat tctcaaacct tccgaatttg tttctacctt tcattttaca ccgtttctta 2423581 tatctatcaa atgccaattt tgcacatgag aaaagagcta gaagaatcct cttagctctt 2423641 ttaacgctct ttctttatta agtcttttaa ttcatcgata aagacgttta tatctttaaa 2423701 ctgccgatag acggacgcga accgcacata tgcgacttcg tcaatcttag ccagccggtc 2423761 catgaccatt tctccgacga gctcactctt cacctcggag cagccttgat tgcgaagttc 2423821 tttttcaata tcaaagcaca tgtcttcaag cgttttgagt gaaacaggcc ttttttcaca 2423881 tgcttttatg aggccgcgca gcattttttc tctgctgaat tcctcacgca caccttcttt 2423941 tttcacaacg atgagcgggg tttcctccac tttctcaaag gtcgtaaacc ggtagtggca 2424001 ggattcgcac tcgcgtcttc ggcgaatcga ctttccgtca tccacaggcc gtgaatcaag 2424061 gactcgtgtt ccgttatgct ggcatgaagg acatttcaat aaaatcagct cccaactata 2424121 tcgttccctg caatgtattt tcggcagcct ccgcctttta aaaatagatg tgacagcatc 2424181 tgtcgggaga gccgttgtta aatttgtttc tatagcatta ggtggtttgt gaaaatctcc 2424241 ttcttatttt acaaaaaaaa tgaaaaaaga aaaagctgac actctcgttt ctttataaaa 2424301 ataaaaggag cataagctaa aaagcgcata atggctttct agcttcagct ccctttgtgt 2424361 tcgcaattta ctttatagta ctttcgcttg cgcctgttta atttgcacag gccccattcc 2424421 tcttggtatt tcaatgtttt ctcttgtatc agcatgtaat gcctctgcaa tgtaatcagc 2424481 agcgacatta ggatctaagt ctccacaagt ataaacatca atgctcgcat atccgtgctc 2424541 aggaaaactg tgaatcgtta agtgtgattc agaaataatc acaactccgc ttacgccttg 2424601 cggtgcaaat ttgtgaaatg caacctcgcg cacctcagca cctgatttta gagcagcatt 2424661 tacaaacgtt ttttcaataa aatccatgtc attcagctta tcaaaatcgc atccccatag 2424721 ctcggagata acgtgacgcc ccattgtttc catagtcatg gacccccctt aacaagaatt 2424781 aaaaagtgaa attccaacaa ctgggtcggc catttaccac gggggaaagt tagtccggag 2424841 aggtcctaac cctttaagta attccgaaac agtctcaagc aagaagttca cgaaaaatag 2424901 tatactgtgt ttaagtctaa tttgcaaggt gcgttttttc agaaatatgc tgttaagggt 2424961 tttttcttta aaatgtgtcc atgaccttat tttatacagc agacggatgt ttcattcgtg 2425021 ccgctacatg gcggattaga tcaacaactc tgcaggagta gccccattcg ttgtcatacc 2425081 acgccagcac ctttactttc ctgtcttcca ttaccattgt tgtaagcccg tcaatgaccg 2425141 ctgaatgcgg attcgtatta taatcagtcg aaacgagcgg ttcatctgag taatcaagta 2425201 caccgtacat cgacgttttg gcagcgcgtt taaatgcctc gtttacttct tcagccgtaa 2425261 catccgtttt cagatcaaca acgagatcaa ccaatgagac gttcggaaca gggacacgca 2425321 aggcgaggcc gtgaagtttt cctttcagat gcggcagcac aagcgaaagc gcctttgccg 2425381 ctcctgttgt tgttggaatg atggattcac cgcaagcccg cgcccggcgc aaatctttgt 2425441 gcgggttatc aatatttttt tggtcattcg tatacgcatg aactgtagtc atcagaccgc 2425501 tctcaatgcc aaactcttca tccagcactt ttacaacagg cgcaaggcaa tttgtcgtgc 2425561 atgacgcatt tgaaataatg acatggcgct cagcgtcgaa ttggtcctca tttacgccca 2425621 tcacaatggt aacgtcttca ttttttcccg gagcggtcaa aatcactttt tttgcacctg 2425681 cttctatatg gcccatcgct ttatctttag cattaaactt ccctgttgct tcgacgacta 2425741 tgtcaatatc atattcccgc caaggcagct gttttggatc acggctgttt aacaaaagca 2425801 ctttctttcc atttacgatc aggctatctt caccagccac aacctctttg tcgtatctgc 2425861 cgtgaattgt gtcatacttt attaaatgag ccagcgtttc tgcggaatag ctggcgttaa 2425921 tggccactac ttgaatttga tcgtctaaca tcgcttttct aaaaaccatt cttccgattc 2425981 ttccaaaccc gttgatcgct acttttacct tcatgttgga caccccttat caattatgcc 2426041 atcctaattt gttactatct aaaattagta taacacatta aaacaaattc gccagtacat 2426101 attgataaaa atcaacgatt ataacgctaa tttatgatgc atcttatgtt ttcttgcaca 2426161 gaatatcagg cgtaagaacc aaaaagcagc cagcgctccg cactgactgc cctcatgctt 2426221 tatgattcct gttttaactt atcattgagc acactttctt ctagcacaga aaatgtatcc 2426281 ccgtacactc tgttaatatg attcgctccc caagcacaca gcatatctaa aatcccttct 2426341 aagctgcggc cgtattcgct gagctcgtat tccactttgg gaggaacttg attatatacg 2426401 attcggttaa tgacaccgtc cgcttccagc tcgcgcagct gctgagtcag cattttttgc 2426461 gtgatattgg gcattaggcg ttttaattca cttgtgcgtt tttttccgtg cgtcagatgg 2426521 cataaaatga cgcatttcca tttcccaccg atcacttcaa gagtcgcttc aacagaaatg 2426581 ttatattttt tcttctccat acaatccatt ctcctcacag gcaccaaaaa gtgactatag 2426641 cacttcaaag tacgtacttt tatttcttaa cgatatgttt cataatcaca tttgccggct 2426701 gatttgaatc tgctcttttt tatttatata gcttactcgg cagaatttca atcatacaac 2426761 acatcttaca aaggaggaac atcatgactt cagccaataa aagcaatatt cctgcactac 2426821 tggctttggc cgtaagtgca ttcgcaatag ggacaactga atttatcagt gtcggccttt 2426881 tgccgctcat tgctgatgac ctggatattc ccgtcacgac agcaggattg accgtttccc 2426941 tttatgcgct cggcgttaca tttggggcac ctatattaac ttcattgacc tcaagcatgt 2427001 cacgtaagac actattgctt tggatcatgt ttatttttat tgccggtaat acgatggcag 2427061 caaccgcttc aagcatcggg attttactag cagcacgtgt gatatcggca ttttcgcacg 2427121 gtgtgtttat gtcgatcggt tcgacaatcg cagcggatat tgtcccggag gataaaaggg 2427181 ctagcgcgat ttcaattatg tttactggcc tcactgtggc aactgtaacc ggagttcctt 2427241 ttgggacatt tatcggccag cagttcggct ggcgtttcgc ctttatggtc attatcgccg 2427301 tcggaatcat tgctttcatt acaaatggca ttcttgtacc gtccaaatta cgaaaaggga 2427361 cgaaaacaac gatgcgggat caattgaagc ttgtgacaaa cagccggtta ttgcttttat 2427421 ttgtcattac agcgcttgga tacggaggaa cattcgttgt gttcacgtat ctgtctcccc 2427481 tgcttcagga agtaacaggc ttcaaagccg ggactgttgc agtgattctg ctcggatacg 2427541 gaatagctat tgctatcggc aatatgattg gcggaaagct gtcaaaccga aatccgattg 2427601 ccgctttatt ctatatgttt atcgtacagg caatcgttct attcgtactg acatttacag 2427661 ccccgtatca agcagcaggg ctcattacca ttctctgtat gggattgctg gcctttatga 2427721 acgtgcccgg ccttcaggtg tatgtcgtca tgctggctga gcgttttgtc ccgagtgcag 2427781 ttgacgtcgc atccgcgatg aatatcgctg cctttaatgc agggatcgcg cttgggtcat 2427841 accttggcgg tgtgatcacc gattcaatcg gattgattca taccgcttgg ataggcggat 2427901 taatggtggt cggtgcagtc attttaacag gctggagccg cttgatggaa aaacgagatc 2427961 ggcaggaagc ctgacaattt taaaggagga aataaacatg acaacacatt tacaagcaaa 2428021 agcaacactt cataatgggg tagaaatgcc ttggttcggc ctcggcgtgt tccaagtgga 2428081 agaaggatct gaactggtaa acgcagttaa aactgccatt gttcacgggt accgcagtat 2428141 tgatactgca gcaatctatg gaaatgaagc tggagtcgga gaagggattc gggaaggcat 2428201 tgaagaagca ggcatttcaa gagaggatct gtttatcaca tcgaaagtat ggaatgcgga 2428261 tttaggctac gaagaaacac tcgccgcgtt tgaaacaagt ctgtccaaac tcggtctgga 2428321 ttatttggat ctatacctca tccactggcc tgtagaagga aagtataaag aagcttggag 2428381 agcgcttgaa acgctgtata aagaaggccg tatcaaagcg attggcgtaa gcaacttcca 2428441 aattcaccat cttgaagatc tgatgacggc agctgaaatt aagcctatga ttaaccaagt 2428501 ggaatttcac ccgcgcctca cacaaaaaga gttgataaga tactgccaaa atcagggcat 2428561 ccagatggag gcttggtcac ctttaatgca gggacagctg ctggatcacc ctgtattggc 2428621 tgacatcgct caaacatata ataaatctgt cgcacaaatt attttgcgct gggatctgca 2428681 gcatggcatt ataacgattc ctaaatcaac gaaggaacac cgcattaaag aaaatgcaag 2428741 cgtatttgac tttgaattaa cgcaggatga catgaaccga atcgatgcac tgaatgaaaa 2428801 cttgcgcgtc ggtcctgatc cggacaactt tgatttttaa tggccaaaaa acaccgttca 2428861 atatgaacgg tgttttttgt attatgccca gctgttcatg atttcatcaa gctgcctttt 2428921 ggtctcttca agcgtgccgc tgttatcaat gacttgatct gctcttgctg ttttttcctc 2428981 taagggcatt tgagagcgga tacggctgac tgcttcttct tctgtcagct gattgcgctt 2429041 catcagacgt tccagttgaa gctcttttgt cacactgacc acaataattt tatcaaccaa 2429101 tgattccaat ttgctttcga acaatagcgg gatatccaat acaacaaatg cctcccgatt 2429161 tgcaacggct tcatcacggc gattgagcat ttcctgcctg actgcgggat gaacaattgc 2429221 atttaaagcg agacgttttt gttcatttgt aaataccagc gctccaagct tttttctatc 2429281 tatatcgcca tttgagagca gtatgtcttc accgaattcg tcaatgattt gccggtaggc 2429341 cggcatccct ttttctaccg cttgttttgc aatgatatct gcatctataa ctgttattcc 2429401 tttttcaatc agcatattgg ctaccgtgct tttgccgcta gctattcctc ccgttaaacc 2429461 aatgactaag gtcaagagat ccactccttt ttacaatttc cagagcccaa tcgtgattaa 2429521 tagaagcccc ggcaaaaacg ccattttatc gatccatttc cacttagaca gaaaatggcc 2429581 ggcattgatt ccaattgata caaacagcga gctcatgatt gccacggcga tgctcatcac 2429641 aatcggcgaa aaaccgagaa tggctgcgcc tatacctgct ccaaaggcat caatcgataa 2429701 ggcaaatccc aataagaccg cctcaattcc gttgatcaca cccgatttgt cgatatccgc 2429761 actcatgggt tttctcaaaa tatgaatcac aattcctaat gaccgaacct ctagattaag 2429821 cagtgttttt tcatgcaata ggtattcttt atcttttgcc ggtttgaaaa attgatacag 2429881 aacccacgca ccgattccaa ccaatatcaa accgccaagc ttctccgtca catatacagg 2429941 aaaaaacttc gtgagaaagc ttccgatcag catggatata aacatgacag caccggaaca 2430001 gcaggcgata accaaaatcg ctttaaacgg tattttcatt tttctcaatc cgtacgtaaa 2430061 tccgactgaa aaactgtcca agctgacagc caacgccagc agcagtatag aaaccatttg 2430121 catatccgtt tcttcctttc tgttggtgct cttgtatcag atgtgaaatg cccgggattc 2430181 atcacaatca tatatatggg aaagtgaaaa atccgtgttt cgaaaatggc atccttaatc 2430241 cagagttact gatatatgca ccgacagctt ggacaatgaa gcattatgct acttttttgt 2430301 ctggcacttt gcgcaaaaat gcgtgcctct tcctccaacg acaattttcg aaatcatcgt 2430361 tccgcaattt ttgcatggct cgtctttttt tccgtacaca aaatgctgca gctggaacat 2430421 tccgatttcc ccttgggagt tgatatatga acggactgtg cttccgcccg catcaatcgc 2430481 ctcctgcaga gtgtttttga tttcagcgtg aagggttttg attgttttat ctgataattg 2430541 atttgctttt gtctcgggat ggacacccgc tctgaaaaga gcctcatcca cataaatgtt 2430601 cccgagtcca actaccgttt tttgatccag tagggcagtt ttgacagcgc ggtttgtttt 2430661 cgcaagccgg tcttttaaat acgcacttgt aaattcttct gcatccggct ccggccctaa 2430721 ctgagaaagc gggagctcgc ccgcttcttc tcccggttta aataagtgca tggttccaaa 2430781 tttccgcaca tccctgtacc ggagctgggt tccatccgtc atcgtgaata tgacatgcac 2430841 gtgtttatcg tcaggctcct cggcttgatg aagaccgtat tttccttcca ttcgaaggtg 2430901 agaaaccata acataatgat ctaaatgaaa cagtaaaaac tttccccgtc ttccgatgga 2430961 ctgtatcgtt tctcctgcta gttttcgcgc aaattcctcc ggttcggcag gccgtttgat 2431021 gatattcggc catctgatct ctaccgattt gattgttttt ccctttacaa gcccggtcag 2431081 agtgcgccgg accgtctcaa cctctggtaa ttccggcaca tccatcactt cctatctctg 2431141 tttatttcgc atcgtaccaa gatgggcctg atgcaaagtc cacctttaac ggcacatcta 2431201 atgcaagcgc atgctccatc acttcaggaa caagcttttc aagaatttca atttcttcct 2431261 ttggcgcctc aaaaatcaat tcatcgtgta cttgaagcag aagccttgct ttcaactgtt 2431321 tttctttcag cttggcagcc atgtcaatca tggctttttt gataatatca gcggcgcttc 2431381 cttgaatcgg cgtattcatg gccgtccgct ccgcaaaact tcggatatta aagttccggc 2431441 tcgtcagctc agggatgtag cggcggcgat gcataagcgt tgttacgtat cctttttgtt 2431501 tcgcttcctg tactgaatct tccatgtacg cttttacgcc ttggaagctt tccagatagc 2431561 ggtcgataaa tgctcccgct tccttccggg taatgccgag gttctgtgac agaccgtaat 2431621 cgctgatccc gtaaacaatg ccaaagttga ccgctttcgc ctggcgtctc atcgcagatg 2431681 tcacttcatc cttagcgaca tggaacacat ccattgccgt tttcgtgtga atatccatat 2431741 cattagtaaa agcttcgatc agattttcat cctttgaaat atgggcaagc acccgcagct 2431801 cgatttgtga ataatcggct gcaaaaatga gccagtcttt ttcagacggc acaaaagctt 2431861 ggcgaatttt ccgcccttcc tcaagcctga tcggaatgtt ttgcaggttc ggatcagtcg 2431921 agctgagacg gccagtttgc gttaaggcct ggttaaatcg cgtgtgcact ttatgcgaat 2431981 ccggtctcgt cacctttaaa agcccttcga tatatgttga ttgaagcttg ccaatttgtc 2432041 tgtactgtaa aatatagtcg acaatatcat gcttgtcagc cagcttttca agcacatcgg 2432101 cagacgtaga atagcctgtt ttcgttttct ttacgacagg aaggccgatc ttttcaaata 2432161 agatgacgcc tagctgtttc ggagaattga tgttaaacgg ctctcccgca atctcatgga 2432221 ttttttcttc atattccttc agcttcgcac ccagttcttc acccatccgt tttaaacggt 2432281 caacatcgac cttgacgcca gttgattcca tttcgccaag aataagcgca agaggcattt 2432341 ccagctcttc aaacagttca agctggtcgt tgttttccag ctcttgaacg agcttttccc 2432401 gaaggctttg aatcgctaac gcttttcggc caaggtgctc agacagtacg tcttctgacg 2432461 gcactgcccg ttttgctcct tttccataaa ctgattcatc acttgaaacg atatgcaggc 2432521 cgtaatcctt agccacactc gcaacgtcgt catatgaatt gcccgggttg atgatataag 2432581 ccgcaaggag cgtatcaaac tcggctcctt tcagctcaat gccctgccag cgcaaagcga 2432641 caacggcccg cttgctgtcg aagacccatt tcttctgctc gtcattttcc acccattctt 2432701 taaacacctc agactcaacg gcaatgtctt tcggaatgaa ataagctccc gtttcattta 2432761 cgatcgaaaa tccgaggatc ggctcttcat gataattatc gccaatctgt tcaacgacaa 2432821 atgcggatgg agaaaccaat atatcgcttg tcacgtctgt gactgttttg acattaatgt 2432881 cttccaacga ttgatcctgt tctgcttctg cactgtcttc tccaagccgt tcaagaagcg 2432941 tgttgaagcc aagatcttta aagatggcaa tgacctgttc acgattaaag ccttgatatt 2433001 ccaggccgga aacagatacc tcaatcggag catccgtcat aattgtcgca agctccttgc 2433061 tcatcaatgc ctgatcctta aactcctcaa gcttttcctt caatttcttt ccgctcacct 2433121 cgtcaatgga ctccagcagc ttttcaacgg aatcaaattg ttttaaaagc ttaatcgcag 2433181 tcttttctcc gacgccgggc acacccggaa tattatctga ggaatcgccc atcagaccct 2433241 tcatgtcaat gatttgttca ggcgtaagcc catatttctc tttgacatgc tccggtgtgt 2433301 aaaattcaac atcggtaatt ccctttctcg taatggcaac tgtcgttttg tccgttgcca 2433361 gctgggttaa atccttatct cctgagaaaa ccttaacttc aaatccgtct ttttcagccg 2433421 atttggccag tgtgccgata atatcatccg cttcatattg ttccagttca tagcggctga 2433481 tctggtaggc atccagcagc tcgcggataa acggcatttg ttcggaaagc tcaggcgggg 2433541 ttttctgtct gccgccttta tattctttaa atgtgccgtg acgaaatgtt gttttcccgg 2433601 catcaaacgc aaccagcatg tgcgtcggtt tttcatcctc aagcattttc atcaaaatca 2433661 tcgcaaagcc gtatacagca ttcgtatgaa cacctttatc attgcttaac agcggcaatg 2433721 caaaaaacgc ccggtaagcc agactgtttc cgtctacaag cactaatttt tttcgttccg 2433781 tcattcaatt tcctcctaag aagcctcagg cttccattca tctcttacat agtcattagc 2433841 tcctcttatt ttaacaaagt tcaatttgaa aggaaaatac gtgaactata agagaagaca 2433901 caaaaaagga cgggaacaca aataggttcc cgccgtcaaa attggctcct tggatgaagg 2433961 ggttctacta catcctacca gcataggttt aacagtgcat gaagatattg ttaaaccttt 2434021 gtaaacatta ggcggacttt tcagcggccc gtttcagcgt cacggtaaag acagttcccc 2434081 gtccaagctc gcttgtgaca tcaattttcc cttcatgagc ctctattaaa tgcttgacaa 2434141 tcgctaggcc cagcccggtt ccgcccgaat ttctgcttct gtctttatct acacggtaaa 2434201 agcgttcaaa gatgcgcgga atttcttctt tctgaattcc gattccagaa tcggcaacct 2434261 caatctgaat gtctttttct ctgggcttta cattgatagc cacggagccc ccctcaggcg 2434321 tgtaggttaa tgcattgttt acgagattaa gaaatacctg tttcagcctg tacgggtcac 2434381 cagatacata ttgagggtct ttcgggacat tcaggtgcaa ggagatgcct ttctcatccg 2434441 ccttatgctt cagaagcgtt tcaatctcac caagcatttt ggccggctca aacgtttcga 2434501 tactgagcgt gaaattttgc tgctcgattt ttgagagatc gagcaaatcc tgaaccaaag 2434561 actgaagcct ttcgctttcc ttaagaataa tagagagaaa ttcagaaagc gcctctttgt 2434621 cttccatcgc cccgtccaat aacgtctccg taaacccttt tatggacgta atcggtgttt 2434681 tcagctcatg agaaacattg gccacaaaat ccttcctcat ctgctctaat ttcttcgttt 2434741 ccgtcatgtc atggaaaacg agcacaattc ctttccattc atcgtccggc cccataatcg 2434801 gaacgccgtc cacttcaaaa taacgccgtt ctattttgat cggcagtctt aacagcttgc 2434861 atttctttgt ctccgtcata aaaatgtctt cgacaagctg gatcacttct tcatgttcaa 2434921 atgcatcgtg ataaagacgg cgcagcatat gattcggatt gatatgaaac tgcttggcgt 2434981 aagacctgtt tacgagatta ataaagcctc ttccgtcgat cataatcagc ccggagccaa 2435041 tgttttcaat gactgtcagc agccgatccc gctgcatttc ctgcgttcgc gtcatttcca 2435101 tcagatcaat ggcaaggctg ttcatcgcat gtcctagctt atcagaacgc ctaatatagc 2435161 cgccgtacgt ccgtgcatcg tagttgccct tagagagttc tgtggctaca tttgtcgctg 2435221 actcaattga ccttttataa cgtgaggtca tgctggaata aaaataaaca atgacgataa 2435281 atgcggtaca aagactggcc gtcagcatcc cccacaattc gccttttaag ccgtcgcttt 2435341 tttcagaggc ggaaagcagc acatatcctg ttttttcacc ttcgcttcta agtgaaagtc 2435401 cgtaataaag cttgttatct gttgttgaca gaataccctc atggccagaa acaagcgcct 2435461 gcaccttttg ggaatcagcc gatctaccgt ttgacccata cagcacctta ccgtctgtat 2435521 cgataacgga tgcgctcaca tcaagcgcgc cgcctgcatc tttaatgatt ttctcatttg 2435581 cttgattatt cagattgccg gcatcaagaa gcgaagccaa gtattttgct tctttttcaa 2435641 tgtgttcctc tgctttcctt tgatcagatg tttcaaaaag ctgctgtaaa aacagcccga 2435701 ggacacaaaa caccagaatc atacagacaa cgaatacaga aaaaaggcgc acacggtatt 2435761 tattcattca tttttggctc ctccagttta taccccaatc ccctaatcgt tttaatgtag 2435821 atcggttttt tggtattgtt ttcaattttg tcgcgaagat ggctgatgtg cacatcaaca 2435881 attctcgtat ctccggcaaa atcataattc cagactgcgc tcagcagcag gtctcttgtc 2435941 agaactctgc ctttatgtct gcctaaatag agcagcagtt cgaattcttt cggtgtcagt 2436001 tcaagctgac tttctttaaa gtacgcttca taatgatcag gcaggatttt cagatcgccg 2436061 attacgatct ggccttccat ttcatcgttc ttcatctcac tagagggcgc agctatttcc 2436121 gaacgcctta aaatcgcttt gactctcgca tttacttccc ttggactgaa cggcttggtc 2436181 atataatcat cagcaccgag ctccagccct aatactttgt cgaattcctc atccttcgct 2436241 gtcagcatta aaatgggaaa catcagtttt tgctgtctca gctgcttgca tacttcgatt 2436301 ccgtccaatt ttggaagcat cacatcaagc acaatcaaat caggtttctc tgtttccgct 2436361 tttttgagtg cttcttcccc atccgaggcg gtaatgacat catagcctga ccgttccaaa 2436421 ttgtactgta aaagagtaac aatagattct tcatcatcca caactaaaat tttcttgttc 2436481 atgctgtgcc tccagtatta taattccccg acatcctatt tctctatttt atgtcatctt 2436541 aacatgtttc atgattttat tttagcgaaa gcaggacatt ccgacaattc gccttttaca 2436601 tcatttttaa aagaaataaa gacgtttatg atagcgcttt catttatagt aaaaagagaa 2436661 aggctgtatt aagcaagcct ttctctcttt ttattaggat aatactttca tgacattttt 2436721 gacagattca actgatttat tcagctgcgc tctttcatag tctgtcagtt caagttcaat 2436781 gatttgctca agaccgttgc cgcctacaat tgtaggaaca ccaaggtaga tgccttcata 2436841 gccgtattcc ccttcaagat aagcaattgt aggaaggacg cggcgctgat ctttcaagat 2436901 cgcttcgacc atttctgtca gagaagccgc aggcgcataa tacgcgcttc cgtttccaag 2436961 aagattcacg atttcgcctc cgccttttct agtgcgctcc acaattgcgt caatccgttc 2437021 tttcggaata agagtttcaa gcgggatacc gccagcataa gaataacgca caagcggaac 2437081 catatcgtca ccgtgtccgc cgagtacgaa accagtcaca tctttcactg acaggtttaa 2437141 ttcctctgcc acaaatgttc tgaatcttgc cgtatcaagc acacctgact ggccgattac 2437201 acgctcttta gggaagcctg attctttgta caccgcgtat gtcattgcat caacaggatt 2437261 tgtcagcacc acaataatag agtcaggaga atatttcacg atttcctgcg taacgcttct 2437321 cataatcttt tcgtttgtag agaccagatc atctctgctc ataccaggtt ttcttgcgat 2437381 accggctgta atgacaacaa tgtcagagcc ggctgtatcc tcgtaattgg atgttcccgt 2437441 aatttttgcg tcaaagcctt gaaccgggct tgcttcaagc atatcaagcg cttttccctt 2437501 tgtcgggttc tccaattgcg gaatgtcaac aagaacaacg tctgccagct ctttttgagc 2437561 gattaaaaat gcagttgtag ctccggtaaa acctgctccg ataacagaaa cttttttacg 2437621 agtatttccc atgtctctct tctcctttat ggctagtttt aggctttttc cttgcttagt 2437681 ccatgttttt gatcagttct tctccgaact ctgaacattt cacttcagtc gccccgtcca 2437741 ttaatctggc aaaatcgtaa gttacgactt tagaagcgat tgttttttcc atagatttga 2437801 taaccaaatc agccgcttcg ttccatccta aatgctcaag aagcagaacg cctgaaagaa 2437861 taactgaaga tgggtttact ttatcaaggc ctgcatattt aggagccgtt ccgtgcgtcg 2437921 cctcgaaaat cgcatgtcct gtttcgtagt tgatgttcgc tccaggagca atgccgattc 2437981 cgccgacttg cgcagcaaga gcatcagaaa tgtaatctcc gttcaagttc attgtcgcaa 2438041 cgacatcaaa ctcgtttgga cgcgttaaga tctgctgaag gaaaatgtca gcaatgctgt 2438101 ctttgataat gatttttcct gctgcttccg cttcgctttg cgctttgttg gcagcgtctt 2438161 ttccttgttc ttcagcaatg cggtcatatt gagcccatgt gaagacttta tctccgtatt 2438221 ctttttcagc aagttcatag ccccagtttt tgaaggcgcc ttctgtgaac ttcatgatgt 2438281 ttcctttgtg aacaagtgtt acagatttgc ggccatgctc gatcgcataa tcaatggcag 2438341 ctctgaccaa gcggcttgtt ccttcttctg aaacaggctt aatgccgata cctgatgtct 2438401 cagggaaacg gattttattg acgtttaact cattttgaag gaagctgata agcttttgca 2438461 cttcttcaga gccttttgca tactcgatgc ctgcgtaaat atcttctgta ttttcacgga 2438521 agatgaccat atcagtatct tcagggcgtt ttaccggtga cggcactcca gtaaagtatc 2438581 ttacaggtct taagcagacg aataggtcaa gctcttgtct gagcgctacg ttcaaagaac 2438641 ggataccgcc gccgacaggt gtcgttaacg ggcctttaat cgcgatgaaa tattcgcgga 2438701 tcacatctaa tgtttcagca gggagccact cacctgtttt attataagcc ttttctccgg 2438761 cgtaaacttc tttccatgta attttctttt cgcctttgta tgctttttct actgctgctt 2438821 ccaaaacctt cgaagccgcg ttccaaatat caggaccggt tccgtctcct tcgataaatg 2438881 ggataatcgg gttgtttggt acgtttaata ctccgttaga gactgtaatt ttttcacctt 2438941 gtgccacaat aaaaacctcc cagtatgtaa ttcatattta gaaaacattt tatttttctt 2439001 atatagaaaa taaaatgatt tttcctaaca ttcaatttaa agtgtaaccc aattttgatg 2439061 tctgaacaag aggctaacct cattgacgca agccagcctc caatggttct ttaggctctt 2439121 tcttcaatcg gaacgaattt ttgtttgtca gggcctgtgt aatctgcccg cgggcggatc 2439181 agacggttgt tgtcatactg ctcaagaata tgagcgagcc agccggacat tctgcttaca 2439241 gcaaaaatcg gtgtaaacaa atcatggtca ataccgaggc tgtgatatac agaagccgaa 2439301 tagaaatcaa cgttaggcgg aagctttttc tctgatgtga cgatgtcttc tatacgaatc 2439361 gacatctcat accatttgct ttcgcctgtc aggttggtca ggcgcttgct catttctttc 2439421 agatgcttcg cgcgcggatc accatgctta tacacacggt ggccgaatcc catgattttt 2439481 tctttctttt caagtttagc gcggatgtac ggctcagcgt tttccacttc accgatttct 2439541 gtcagcattt tcataacgcc ttcattcgct ccgccgtgaa gaggcccttt cagcgcgccg 2439601 attgctgcag taatgcctga atagatgtca gaaagtgttg cgacgcagac cctcgctgtg 2439661 aacgttgacg cgttcagctc atggtcagca tgtaaaatca atgctttgtt gaaggcttca 2439721 acttcaattg gtgaaggctc ttcaccgttt aatgtgtaaa gaaaattctc cgcaataccg 2439781 taatcttctc tcggttcaac aggctcaaga cccttgcgaa ttctggaaaa cgctgcaacc 2439841 aggccaggca cctttgcctg aaggcggatc gcctttctgt agttggcttc cgggttcatg 2439901 gtatcagcct cgctgtcaag caggcctagt aatgaaattg ctgtccgaag agcagccatg 2439961 ggatgaacat tttcgaggga ataagatttg aagtgctcaa taatttcttg cggaacggca 2440021 gcttcctttg caagctgctg ctttaactct tcaagctctt ttttgtttgg cagccttaga 2440081 tgccaaagca agtagatgat ttcttcaaaa cttgcattct ctgtcaaatc atcgatatca 2440141 taccccacat atgtaagggt atcatcaata atagaactaa cagatgatgt tgttgctaca 2440201 accccttcaa gaccgcgtgt cgctgtcata tataacatct ccttttcaat aaatttcccc 2440261 tttaagagtg ttgtaaaaac atgaggctta cttaaaaagc acgatgcaag tatttctctc 2440321 ccccaaaaag aaaatgctta cattttactg gctgctggaa ctaaaaccct ttgcttttga 2440381 aagaacataa caaattttta taagcttatt taagtttaag cctattctca ttataaacaa 2440441 taatcagaca tttgttaaat gtttacctat aatttttttt ttccattctg tgatttcccc 2440501 gaaaaaacgc ctttatttgc gggtttttgc ataaaaaaaa gcggctttaa ggccgctttt 2440561 ttttatgaag tgaacagttt tacgatctgc atggctaaat aagcaatccc cgctccgatc 2440621 agcggcccca ccgcaactcc tccaaaaagc gcgactgcaa gaatggtccc gatcacgaga 2440681 gcagttgtaa tatgcggatc attttcaagc agggtcaggc cgttttttgc aatcagcgcc 2440741 actgcgatcc ccgctccaag ggcgatccat gcgtaggaag accgcattgc ttctccaagc 2440801 tgcttaaatc cgatttctcc cgtggcaatc gggacaagaa cggcgatggt aataatggtc 2440861 acaccccagt taatgccttt tgactggatg gtcggaaata atttctgatc aagcccaacg 2440921 attttgatga tcaaaaggac ggatacagca aagagcaatg attggttttt tgcgataagt 2440981 gcgatagcca agagtaaaat taaaaataaa ttcgcttgtg taaacacatg ccatccctcc 2441041 tttaagatga atgtattcat attcagccgc agcgtgaata catataaaaa ataggacatg 2441101 ctgacgagag gaggaccgtt tttgtgaatc aatcttatat cactattttt ttcagaaccc 2441161 tctttgtcat atcaatgacc gcagggtcga tagctgcggc ctattattcg tttccgttaa 2441221 cttatccgtt cctgatcgcc cttattctat cttcagtgat tcatcctgtt gtcgattatt 2441281 tggacaaagt gacaggattc ccccgaacga taaatgttct gggcgttctt gctttttttc 2441341 tgctcgcagc cttcggcgtg ctcaccattc tggtagccga aatcgtaacg ggaacagcct 2441401 atctagcaaa aacgctgcct ccgcatatca gcacgtttat ttcatattgc gaaaaattgt 2441461 ttaccactca tattcagccg ctctataacg agttaactct tttgtttcaa gaattggaaa 2441521 cgaaccagca ggcttccatc gtcactcata tccagacact cggtgattct gccgctaaaa 2441581 atgccgggct cctgctgtcc cacattctag agatgatccc gagatttttc gctcttcttc 2441641 ccaatacggc ggcggttctg attttttctc ttctggcaac cttttttatg acaaaggatt 2441701 ggcataagct gaaagccatg cttgttttaa ttctgccgga tcgtgtgaca gctaacagca 2441761 aagcaatcag cagcgaatta aaaaaagcaa tgactggttt tatcaaagca caagccgtcc 2441821 tcgttttcat cacgatggtg attgtattta tcggcctttc tctcttaaag gttgaacacg 2441881 ccgcaacaat tgctttttta atcgggcttg tagatcttct cccttactta ggtgccggct 2441941 ccgtatttgt gccctggatt ttgtatttat cgattacggg ccagctgccc caagcaatcg 2442001 gaattggtat cctgtacctc gtcgttctta ttcagcggca gctgacagag cccaagatac 2442061 taagtaaatc tatcgggatc gatccgctgg caacactcat cgccctgttt gccggcttta 2442121 aattattcgg gtttttagga ctgattgcgg gaccggctgt actcgtcatc atccaagctt 2442181 tcatcacaac aggcgcatta aaagaaatat ggtcctatat caccgttcag caaaaataaa 2442241 acggcagccg ttttttcatg gctgccgttt tttatttgat gatgatccgc ttattcttcg 2442301 acattcctct cagccatttg aacagaatcg gcttacacca gccgcgggta aacgggataa 2442361 gaagacaggc gccggccaaa tctgataaaa agcccggaag catcagcaat agaccgccaa 2442421 tgaaaatgca cagaccgtca gcaatcgctt ctcccggcat tttgccatat tgaagatcac 2442481 gctgaacctt ataatacact tcggttcctt gtttttttgc agctgctgcg ccgataatgc 2442541 cagtcagaat catgaataga actgtcggca aaataccaat cagatttcct aaaaatagga 2442601 atataccgat ttctattgcc ggaaacacaa taaaaagcaa aaacaaaaat ctcatatcca 2442661 agccccccac acgtgtaaca cgttctgttc aacaaaaggc atgataaaga gaaaaggaag 2442721 ggattcccct tccattttca cctgtaatta aagaacgctc gcacggcctt gatagactgc 2442781 gcctctggaa gcgtcaactg taatatcctg gccatctgtc aaaatagatg tcgcattttc 2442841 cagacccacg ataaccggga tgccaaggct taatccgact accgcagcat ggctagtcaa 2442901 accgccttct tctgtaataa gagcagacgc tttttcaagg gatgcaatca tatcacggtc 2442961 agtgcttttg gtaacaagta ccgcaccgtc agtcattttt tgctcagctt cttttgcatt 2443021 ttgtgcaacg acaaccggac cgtaagctga tttgcgtcca atgccttggc ctttagcgat 2443081 gatatcgccg acagtatgaa ccttcattaa gttcgtagtg ccggactcac cgacagtgcc 2443141 agctgtaata acgataagat cgccgtgttt tacaattccg ctgttcaatg atttttggac 2443201 agcatcctca agcatctcat ctgttgagct cgcattttgg ccgctttccg cgaatacgcc 2443261 agatacgagg gcaagctttc tggaaataga gtcatttaca gtaaccgcaa caatcggagc 2443321 ctgcggacgg tattttgcaa tcatacgtgc tgtatggccg ctttctgtcg gcgttacgat 2443381 cgcagcagca ttcaggttaa tcgccgtatg tgcgacagat tgtccaattg cgtctgtaat 2443441 tgtcatgccc acttggtctc tgcgttttga gagaatttct ttataattta atgcttcttc 2443501 agaacgggac gcgatgttat gcattgtttg aactgcttca accgggtaac ttccggcagc 2443561 agtttcacca gaaagcatga tcgcatctgt tccgtcgaag atcgcgtttg caacgtcact 2443621 tgcttccgca cgagtcggac gcgggttgcg ctgcatgctg tcaagcattt gtgtcgctgt 2443681 aataacaggt ttgcccagcg cgttgcattt tttgatcagt tctttttgca caagcggcac 2443741 ttcttcagct ggaatttcca cacctaagtc tccgcgtgca accattaagc cgtcagacac 2443801 ttcgagaatc gcatcgatgt tgtcaacgcc ctcttggttt tcgattttag ggatgatttg 2443861 aatatcctga gcgttgtgct cttcaagaag ctcacggatt tcgagcacat ccgtagaacg 2443921 tcgaatgaaa gatggtgcga tgaagtctac tccttgctca ataccgaaaa cgatgtctcg 2443981 cgcatccttt tcagtaatcc ccggaagatt gacacttacg cccggtacgt taacaccttt 2444041 tttatttttg agtgttccgt tgtttaatac ttttgttttg atttcgcgtt tagcggcatc 2444101 tacatcaagt acctcaagac cgataaggcc gtcatctaac agaatcgttg aaccttgttc 2444161 aacgtcatgg actaaacctt catatgtcac tgaaatttta tctgttgttc ctacaacctc 2444221 gtccattgaa ataatgagct ctttgcctgt ttcaagctca ataccgccgt tttccattgt 2444281 atgtgtgcgg atttcaggac cttttgtatc aagcagaatt ccaacgttct tgccaagttt 2444341 tttacttgct tcgcggatat ttttaattct tgcaccgtgc tcctcaaaat ctccgtgaga 2444401 aaagtttaat cgagccacgt tcattcctga ctccattaat ttcgtaagca tttcaatact 2444461 ttcacttgcc ggaccgatgg tacaaacaat tttagttttt ctcatttggt tcacttcctt 2444521 ctgaaatctt cagccttcag ctgtacatta gatagacagt tcttttgaaa gctgatacat 2444581 gttttgctca actgtgtgtt ttgtctcaag tatttctata atatcatggt ctacaagctt 2444641 attgttttgt atacctacac agcgtccgcc ttttccttca agcagcagtt caactgcata 2444701 tgcgccgaga cggcttgcca acacacggtc agcagcactc ggagaacctc cgcgctggat 2444761 atggcccaat acagataccc tagtttcaag atttgtttct tcttcaatgc gtttcccgaa 2444821 ttcaacaccg ctgcctacac cttcggcaac aataataata ctgtgcttct tgccgcgttc 2444881 gtggccgcgt tttaagcggg caatgatttc gtgcatgtca tagtctgcct cagggattaa 2444941 gatcgattct gcgccccctg caagaccggc ccacaatgcg atatcgccgg catgacggcc 2445001 cattacttcg attacatatg tacgttcatg agaagtcgct gtatcgcgaa tcttatcaat 2445061 tgcgtcaatt actgtattta aagctgtatc gaaaccgatt gtaaaatcag tgcccggaat 2445121 gtcattatca attgtacccg gtacacctac acatggaaac ccgtgttccg ttaatttttt 2445181 cgcacccata taggaaccgt ctccaccgat aacaacaagg ccttcaatac caagcttctt 2445241 caagtttgct atcccttttt cacggccttc aactgttttg aattcaggac atctcgccgt 2445301 ataaagctta gtccctccac gatgtataat atcgcctact gatccgagtt caagcttttc 2445361 aatctttccg ctgatcaatc ccgcgtatcc gttgtaaata ccgtaaactt caacgtcatg 2445421 atagatcgct tttctgacta ctgcgcgaac tgctgcgttc attcccgggg aatccccgcc 2445481 gctcgttaat acccctattc gtttcattct ccattcacct cagcaacata tatgattaaa 2445541 cataacatga tcattgccct aaaaacaatg aaaagggatc tccatcctcc ctatgaaacc 2445601 ttacctatta tacaattaaa taaattgttt ttaaataaaa tttaaggaat gtcacaaaaa 2445661 ataaacgtga gccaaaggct tcacgtttat ttagtttacc ccgatatatt gatcttcaac 2445721 cgagactttg ccaattgctt tatatttttc ataacgctgc tgaactaatt cttcttcgct 2445781 cagcttcagt aaagttttta acgattgttt aagggtttcg tccatatagc ttgcctgcag 2445841 cttcacatca tggtgcgctc cgccttttac ttctttaatc atatgatcta taatacctaa 2445901 ttcttttaaa tccggcgcag tgattttcat tgtttctgct gcttttttag caagactgga 2445961 gtccttccat aaaagtgccg cggcaccttc cggagaaata acagaataag tagagttttc 2446021 cagcatatgc aagtgattgc ctacacccag accaagggct ccgccgcttc cgccttcacc 2446081 aatgacgatg cagataacag gcactcgaag gccggccatc tcaaacaggt ttttggcaat 2446141 agcttcactt tgtcctcttt cttcagctgc tcgtccaggg tatgccccct tcgtatcaat 2446201 aaaacagata attggtctgt taaatttgtc agcctgtttc atcagacgaa gcgcttttct 2446261 gtagccttct ggatgcggca tcccaaaatt gcggactagg ttttccttcg tgtctttgcc 2446321 gcgctgatgc ccgattaccg ttacagggag gccgtggaac ttcgcaatcc cgccgacaat 2446381 ggcttcatcg tccccgtacg ctctgtctcc gtgacattca aaaaagtcgg taaacaggtg 2446441 ttcgatataa tcaagagttg tcggacggtc cgccagacgc gcgatttgaa cccggtccca 2446501 cggcttcaaa tttttgtaaa tatcatcctg aagcttagcg agacggtctt cgagccgttc 2446561 gatttccgca cttagatcca tatcggaatc ttgggtgaat ttttttagtt cggcgatttt 2446621 ggtttgcagt tcaatcaccg gtttttcaaa ttctaatctt ggagccactc aatgtcacct 2446681 cctgtttgat gcatatccag cagattttct aacgtttttt tcatatcgtc gcgatgaata 2446741 accgcatcaa gctgtccatg ttttaataaa aactcagccg tttggaagtc ctcaggcagt 2446801 ttttctccta ttgtctgttc aataatccgt cttccggcaa aaccgatcag cgcgccaggc 2446861 tcagcgaaat tgtaatcgcc aagggatgca aagcttgctg atacgccccc ggtagtcgga 2446921 tgcgtcatta ctgaaataat aagaccctgt tcttcactga acagttttaa cgcagagctt 2446981 gtctttgcca tctgcatcaa acttaatacg ccttcctgca ttctagcacc gcctgaagcc 2447041 gtaaaaataa taaacggaac tttatcagct tttgcttttt caatcgcaag cgtgattttt 2447101 tcaccgacga ctgaacccat gctgcccatt ctgaatgaag agtccatgac ggcgacaaca 2447161 gccgggtgtc cgccgatggt gcccttgcct gtcacaacag cctcgtttaa ggatgttttc 2447221 tcgcgatctt tttcaagctt ttccagatat cccgggaaac caagcggatt ttccgagagc 2447281 attccctgat taaattcctc aaaggattgt tcatccatca agctttcgat acgctgtttt 2447341 gcgttcattg ggaaatgata atcgcagttc atgcataccc gcatattttt atccaactct 2447401 ttagtgagca tgattttttt acacttagga cattttgtca taatgccttc cggaacatcg 2447461 tgcttcgctt gatcagacgg tacggaagca tactttttct ttttcgtgaa tatatccttt 2447521 aacaaatgat tacctccctt ttgtgaaggg ttctcttcac cgcatgtcat caaacagata 2447581 gacttgctaa taactttacc gaaactattg tacttttttt gtcaaacgct gtcatcctca 2447641 attcgacaac tttttattcg atgacgtgct cggaaaggct tgtatgaaat cagataaggt 2447701 gttgaaacga caaggttgac agcgcattca aaaataatgt taaacccggc tgaaattttt 2447761 ttaaggctaa ccccctaaaa aaatttcagc cgtcagttta acttgagaac agcgcgccgg 2447821 tctccgccaa cgcgctgcca tttttggaat gaattaaaat tattcaccaa taatcgtaag 2447881 ttttcttgtt ttttctgcga cttcctcagg gtcaacagtg attcttgcaa cacctgtttc 2447941 catcgcagct tttgccacag ccttcgcaac agcaggcgca acacgtttat caaacggtgc 2448001 agggatgaca tagtctgcgc taagctcatc ttctgaaacc agtgaagcaa tggcttcaac 2448061 cgctgcgatt ttcatttcct cgttaatatg agtggcacgc acatcaagcg ctccgcggaa 2448121 aataccaggg aatgcaagaa cattgtttac ttggttcggg aagtcagaac ggccagttcc 2448181 gacaacgctt gctccggctt cacgcgcatc ttccggcatg atttccggat ttggatttgc 2448241 cattgcaaag ataatcggat cttttgccat gctttgaacc atttcttttg ttaacgcgcc 2448301 tgctacagag acaccgataa atacgtcagc atcaacgata acatctttca gagaaccgtc 2448361 tttgcgatct tggttcgtga acttcgccac ttcatttttg acatcgttca tgccgttcgg 2448421 gcgcccttca taaatggccc ctttggaatc gcacatcaca atgtcgcgaa cgccataatg 2448481 atgaagaagc ttgataatcg caatgccagc cgcacccgcg ccgtttgcga caactttaat 2448541 ggatgacatg gattttccag acagtttcag cgcgttcaca agacctgcta cggttacaat 2448601 ggcagtaccg tgctgatcat catggaaaac cgggatgttt gtttcttttt tgaggcgctc 2448661 ttcaatgata aagcagtttg gcgctgcaat atcttcaagg ttgacgccgc caaatgtcgg 2448721 ttccagcaat tttacagttt caacgatttt atcaacatcg tttgtgttta aagcaatcgg 2448781 gaacgcatct acgcccgcaa agcttttgaa aagaactgct ttcccttcca taacaggaag 2448841 cgccgcttca gggccgatgt ttccaaggcc aagcacagct gtaccgtcag ttacaactgc 2448901 taccatgttc cccttcattg tataatcata tactttgtta atgtcttcat gaatatcctt 2448961 acacggttct gcaacacccg gagaatacgc gaggcttaaa tctttcgcat ttctgacctc 2449021 tacttttgat ttagactcca gtttcccctg gttgacttta tgcaggtgta atgcttcttc 2449081 tcttaatgac attctcctaa acactcctta tggatatttt ttgattcgta tactgctgcg 2449141 ttgattgctg cattctgcgg agtaaatcta tctgaatatt taaacaggat cacataattg 2449201 ctccaattgt ataacaaaaa gcgaatcgtt accactgttt taaaacgacg tttttttgac 2449261 ccaacagctc ttttaagcga tataacacct ggtgatctgc attgatatgg aacgactcag 2449321 gtagcttaat cgtctgtttt tgcctttcat aatagagata aacgcctgtt tcccctttat 2449381 gctccagcaa aatgcgctta atctttgcca ggatctcctg gctgtgctga ctgctttcta 2449441 tttttatata aaccgatggc gctttttctg catccatatc ttctaataat tctgcccggg 2449501 acatgatgaa ttggatctta tcttgtctaa cttcacattt ccccgcagtg aacaaaagag 2449561 cgccttctct taaaacggga gaaagctgtc tgaattgttc agggaagact acggcttcca 2449621 tctcgccggt ttcatcactg agcgttaaaa acgccatgtt ttgacctgtt ttcgtccgaa 2449681 tcgttttgat cttcgacagc agaacgccta gtgaaagctg ccttttgact gcccgctgag 2449741 cctgcagaat ggagactgct ccttgcgcag tgagctgttt tcggaaggcg gagaggggat 2449801 gatttgaaaa ataaatgcca agcgtttcct tttcaaacgc aagtaaatcc accagaggaa 2449861 gctcctccgt ctccacatac ttcggcttaa ttgaaaacga ttcatctaaa aacaatccca 2449921 tttggtcatc gtccgcggcg aatagctcag catgttccaa agcaacatca atggatgcga 2449981 gcagcgtggc ccggttttgg ccgaattcgt ccatcgcacc agaaaagata agtgcttcaa 2450041 gcattttgcg atttacgctt tttgacggca cgcgaaagca gaaatcgaaa agatcttcaa 2450101 atggtttctc ttttcttgct ttatatatat ctttgactgc tgagacgcct acacttttta 2450161 tcgcgcggag gctgtatctg acagatccgt tttcaactgt aaacggaaaa ctgcttttat 2450221 tcactgacgg aggaaggata cgaatcccgc tcccctttgc ttcgtaaaga tattgagaga 2450281 ttttatcctc attgccaatg acgcttgtca gcaatccgca cataaaatat aacggataat 2450341 gagctttcaa atacgcaagc tggcacccga tcatgctgta tgccaccgca tggcttctgt 2450401 taaagccata gtttgcgaat ttgacgatta aatcgtagac ctcatttgca gtgtctacag 2450461 aatactcctt ttttaagcac ccttcaacaa aatggcttcg ctctctgtcc aggatttctt 2450521 ttttcttttt gctgaccgcc cttctcaata ggtccgcttc gcctaaagaa aaccccgcca 2450581 tacgggaagc aatcatcata atttgttcct gatacacaat gacgccatat gtatcttcca 2450641 aaatgctcct taaatcttca tgaggatagt gaacaggcgc ccgaccgtgt ttacggtcga 2450701 taaataacgg aatattttcc atcggacccg gccggtacag tgcattgacc gccacaatat 2450761 cttctaggcc cgaaggtttc agccgtttca agacgcttct catccctgca gattcaagct 2450821 ggaaaatgcc tgtcgtatcc ccttttgaca gcaaggagaa cgttttgtca tcgctgtagg 2450881 aaatacttga aaggtctatt ttaatatttt cttctttttc aatcattgaa gtgatggatt 2450941 caataagtgt cagattcctc aaacctaaga aatccatttt taaaaggccc aagtcttcaa 2451001 gatggtccat cgcgtattgc gttaaataga tcccttcatg cccttcttga agcggaacaa 2451061 catctgttaa cggttcttca ctcaggacaa cgcccgctgc gtgggttgat gcatgccttg 2451121 gcagcccttc tattttccgg gcaattgaat agacttgctg aagcaggctt gactcccgaa 2451181 gccgcttatc cagctgcggt gactgctgtc tcgcttcatc cagcgtcatt cccggtcttg 2451241 aaggaatgag ttttgcaagc tgatctgcct ccttcgggct gacgccgaat actctgccga 2451301 cgtcccggag cgccgccttt gccgcaagtg ttccaaaggt gataatctgt gcgacgtgca 2451361 ttgcaccgta tttctgctga acatattgaa tgacttcatc ccttctagta tcgggaaagt 2451421 caatatcaat atccggcatg ctgacgcgtt cgggatttaa aaatctttca aacagaaggt 2451481 gatgcttaat cgggtcaaca tctgtgatat acagcacata tgccacaaga gaacccgccg 2451541 cagaacccct tcccggtcct gtaacaatcc ctttttcatg ggcgtgcttc ataaaatccc 2451601 acacgatcag aaagtaatcg ctgaacttca tccgcttgat gacatcaagc tcatattgaa 2451661 gacggcgaag gtatcgttca tcaggcttgc cgaaacggct gcggagtccc tccatacaga 2451721 tatccgttaa ataatcatca gcggacgttc cgtctggggt cggaaaagac ggtagacggg 2451781 tctgcccgag actgacgtca acccggcatt gttccgcgat ctctacagaa gcttgcagtg 2451841 cctcgggatg ctctcgataa atgttttgca tttcttcgag tggtttcaaa tcgagatcag 2451901 gcaaatcttc agcgggtgca tccgtcagtt tttcccccgc tttaatcgct ttcaaacaac 2451961 ggtaggcagc cttatcttcc ttccttatgt aatgcacatc gcctgtggcc gtaacaggga 2452021 tacccgtttc ttctgacagc tttagaatct gctcagacaa gacttgattc cctttaaaag 2452081 gctgatagga gaaataaaaa gctccctttc cgaatataga ctgaaattcc agcgaggctt 2452141 gagcagcctg ttcgaacagc cctccttcaa gaagcgtttc aatatatcct ttttcgccgg 2452201 gcgttattgc gataatccct tctcgataac tgtgaagcca tttcggcttc agtccgcctt 2452261 ttgatttaga ttgcagaacg ctgctgattt tcagcaggtt ttgatagcct gtattcgatt 2452321 ttgccagcag gacgagcggg tatgcttcaa gctcgctgtc atctgtaaaa acagaagccg 2452381 tcaaaccgat tattgggttg atccctctcg ccttgcaagc tttataaaat tgaatagctc 2452441 cgtacatgac atgatcatct gtcagcgcca aagacgcata tccgagcctg tcagcttcac 2452501 tgacgagttc ttccacagcc gcggcgctgt ttagcaggct atacccgcta tgcacttgca 2452561 ggtgaacaaa agacatgcta tcacctcttt ctcattacga tccatttctt ccttcattat 2452621 aaggccggtt tccaaaagaa acaaatgttc ttttttgact catcatcata cttgtcctga 2452681 aagctcaata tgatataaaa ggtgaggtga taaagatgga tcaggaagca ggatttatgg 2452741 tgaattttat caatagctac ttcattgcgt taggggtgct gatcgggggc gcactcatcg 2452801 gagggctcgg agcatacttg gcaggcgaac ccccgcttac agccattaca aagcttgcca 2452861 accggttaaa aatatgggcg cttgtcgcag ctatcggagg cacctttgat gcggtataca 2452921 gctttgaacg cggcatactc gaaggcaata cgagagatat ctttaaacag cttcttttaa 2452981 ttatttcggc catggggggc gcgcaaagcg gctggcttat tatatcatgg ctgacccagg 2453041 agcatctttc ttcatgaggg tcccccagca ttacaaaaaa ccgggatggc agcgtttttt 2453101 cgcgggaatg atgtgcggag ccgtaatcag ctggttcttt ttcctgttta cttacggaac 2453161 attccaagag gagcaggtca gcctcatcga aaagcaaaaa gagcatgtaa aagacttgaa 2453221 caatcaaatt tcgatctatc aggaagacct ccataaactg aatgaagata ataaaagaaa 2453281 actgctgatt caaagcgtca gcgtcaaatt gctgaatggg gataaatata aaatatcaca 2453341 gccggataaa acgaaattcg aggagcatgt aaaggatgat atttcagagg tgattacaaa 2453401 agacatagag agcgtctatc aaacaaagga tctcttgaag cggacaattg aaaataaagt 2453461 ctatatgatc aatgaaaaaa aatacgaggc aaccgtcaga gaattgatta tttatacgag 2453521 gctgacagtg gaacttgaaa tttctttcgc cacataatta tggatttttt ttaaattctc 2453581 caaacttctg tcgctttttc ccattctttt ttataaacta tatgtgaggc ttaatggcga 2453641 aaggaaggag gaagggaaat ggaggtttac agtgaccgtc agttagcaaa agatcaagca 2453701 gcccgtctca gacaaggttt ttctgcatat gccgaaacaa actcactcgc ttccctcatc 2453761 aaaaaagaac ttcaatcaca caatctccaa gtctacgagg accttactga tttcggctgc 2453821 tggttcatcc ccgtcacaga tgaacactaa gagagagggt ctcccctcta ctcgtgttct 2453881 ttacataatg tttccagatc agctaaaata cgatcagctt catcccagct gtaaatagag 2453941 gcgcctgaag ctaacggatg ccctccgccg ttatatttcc gggcaagtcc gttaatgaca 2454001 ggccccttcg aacggaatct gactctgatt tgatcgtctt cttctacgaa aaacacccag 2454061 gcgcgaatac ctgagatatt gccaagcgtc ccgacaagct gcgacgcttc agaagccgtt 2454121 gtgccgaatt tttcaagcgt atcctttttg atgaaaacag aagccgcccc gttttcggac 2454181 aaagacacat tttgaaagat aaagccgtta agcttcacca cattcagttt tgtttcatac 2454241 aattgattaa ataactctga ggaagagaat ggatactgaa tgagctcgcc tgcatatttt 2454301 agtgtttttt ccgtggtatt cggaaataaa aagcgtccgg tatctccaac aatgccggcg 2454361 tagatcagct ctgccgcttt cgtattcagc ttccagccgt gctcttttcc ttctaaatac 2454421 agctcgtaaa tcatttcact tactgagctg gcgcttgtat cgacccagag aaggtcaccg 2454481 tatggatctt cgttcggatg gtggtcgatt ttcattagtt tggcgcctga aggataacgc 2454541 tgatcgtcga ttctttcctg atttgccgta tcgcagacaa tgacaagtgc gccttcatat 2454601 gtttcattgt ccacctcatc aagggaatat aagaaagaga gggacggttc aggcgtgccg 2454661 accgcaaaaa tatttttttc aggatatgtt tcacgcagga tttccgtaag cccacactgt 2454721 gatccgtagg catccggatc aggacgcaca tgtctatgta agataatcgt gtcatataat 2454781 gatatggttc tgatcaattc tgttttcatt tgatactcct ttattgtttt tattcattaa 2454841 atcacattct ctgccgacgg aaaagaaaaa taacgtcaaa accaagcccg tttttgtata 2454901 aaatggggtt gtaaactttt acgatggagg atttcattta tgctggttct tgtttttttg 2454961 attgggcttt cagcctgctt ttatgtgtac tataaagtaa aaggcgtacg ggcaaagcca 2455021 tctttggcaa aagaaatatg ttcagcaaaa tcaagcatgg ccttagggtc actagtcctg 2455081 ttctacgggc ttaaccaaat gatattattc cattcagtat taacgttagt aatcggcggt 2455141 atctttatcg tcataggagc aggaagcgct tgggcaggtt ataaagcctt caggcattac 2455201 aatccccttc acgccaaaga agctgaaaga gatcacgcgt aaggggcgcc tgaacgtccc 2455261 ttagcttctt tccatcagct gaaccatcag catcgcttta gacacgatat gaccttggct 2455321 gtgcacttcc acttccattt tcccaaactt tctgccggcc tccaagatgc gaggtttgac 2455381 ttcgatgact gattccatct gcacaggctt caaaaagaag atggtgatgc tctctatgac 2455441 gagttcgccg cgttttttcg agcgcaaaaa tcggtttgcc gcttgcgtca aaatggtcgt 2455501 aaatacgcca taagaaatgg ttccaagctg atttgtcatt tgcggcgtga cttcatactc 2455561 gtaaaccgtt tgatcttctt tatcatcacc ctcatcttta aacccccttg aaacgatatc 2455621 atcaagcttc tccccgacct gcggctgctt ttgaatcatt tgaagagctt tcaatacgtc 2455681 ttggcggctg atcatgccga tgagtttttg gtggccgtca gtgacgggaa gcacttcgat 2455741 cccttcccat accatcattt gcgcagctga agcgacagat gttttcccaa taaccgtgac 2455801 gggatttttg gtcatgactt tttctataga tgcatttcgg tcatggccag caatatcttt 2455861 tgatgtcaga atgccatgga ttttcatttg atcgtcgaca accgggaagc ggccgtgccc 2455921 cgtttcaaaa tttttctcat accatttttc aagtttatcc ttaggcgaaa gatataccgt 2455981 gcggtcagca ggtgttagga tgtcctccac caaaacaatt tcttttttga tcagctggtc 2456041 atatattgcc cggttaatca tcgcggcaac tgtaaaggtg tcatagctcg tggataaaat 2456101 cggcagttca agctcatctg ccagctgcac aatgctgtca tccgtgttaa agcccccggt 2456161 caccaatacg gccgcgcccg cttcaagcgc ctgcctgtgt gcattgattc tgtttccgac 2456221 aatcaaaaga ttccccgctg cggtgtaacg catcatcgcg tcaagctcca tcgcgccgat 2456281 gacgaattta ttcaatgtct tatggagccc tgccctgcct ccgagcactt gtccgtctat 2456341 aacatttaca acctctgcat aggtaagctt ttcaatgttc tcttttttct tttgttcaat 2456401 tctgattgtg cccacacgtt caatcgtgct gacaaaccct ttattctctg cttccttgat 2456461 cgctctgtac gcggttcctt cgcttacttt catttccttt gcaattcttc ggacagaaat 2456521 tttttcaccg acaggcagtg aatcgatata cgttaaaatt tgttcatgct tcgttgccaa 2456581 gcctttcacc tctaaggaca gtcttcttgt ttttattata aggtttcaaa ggatttatac 2456641 gcaatgaggc tggaaaataa aaaagaagcc cgaccggctt cttacagcgt tgatttcgtt 2456701 ccagtcaaac gcaaggacca cgtgattcct tttacatcgt aaagcggaaa aacctttatt 2456761 tttcttttaa atggacatca accgctgtct taacaatatt tcgattccct attttagata 2456821 aaacaaataa aactgcggat agccatatcg cccctatggc cgtatagatc aatggatgaa 2456881 cagctgtgtt tgcgatccat tcatttatta atgttctggc atttaccaga ataataaatc 2456941 ctcctacaag cacacccatc aattgcggat gaaacttctg caccagccat gctgcgatag 2457001 gggcagcgat aattccgccg gccattagtg aaaacaccca taaccaattg acgtcctccc 2457061 atcctaatga aataagaaaa ccggcggttg cagatacggc gatggcaaat tcacttgtgt 2457121 ctacagtccc gacaactttc ctcgggctca agcctttgcg ggataataaa atcggagtgg 2457181 tcaccggtcc ccagccgcct ccgcctgtgg catctgcaaa accagcgatc actcccaatg 2457241 ggatggattg ttttcggttt aacggcacat gcttcttctc aagagccggc ttatattgaa 2457301 ataaaaacct gatcaataca tatccgccca gaaggagcaa aaacaaagaa atatagggtt 2457361 tcgccacatc tccaggtaat tggctgagga atgccgcgcc taaaaaagcg cctatagagc 2457421 cgggaatgac aagctgataa acggtttgtt tgtcaacatt gccaaattta atatgcgaca 2457481 ctcccgatgc ggcagtcgtt acgacttccg ctaaatggac agaagccgaa gccacagcag 2457541 gtgtgatgcc aaacgccaat aacaaagaag ttgaggtaac cccataagcc atacctaacg 2457601 aaccgtctat taactgcgac aataaaccaa taaatgcaaa aacgattaat ttcttcatca 2457661 gaacacccca tctatatcaa tcagatattt ttgactcttc attcgaatct aacaatctct 2457721 tggcgctttc atataaaaaa taagaggctt tgataattgc agtttcatct attgtaaatg 2457781 cagggtggtg ccaatcatga tcaccgtctg ttccaaaaaa cgcaaaggat cccggaatat 2457841 gctcaagata ataagcaaaa tcttcccccg cggttgatgg ggcgggatca atgacttgaa 2457901 gtttcgcttt atgtgcagcg tctcgcacca gccccgtaat tgcctcatca ttacaaagcg 2457961 gcggcggtcc ggaatgccac ttcacatttg cctttaacga gaaagcggca gaaatctgct 2458021 ctgtgactgc aaaaaaacgc tgtttcactt gattacgaac ctctgaatca aatgtacgaa 2458081 cagtgccctc aatgaccact gtatccggaa tgacattcca agtgctgccg ccgttgattt 2458141 tccctacggt taaaatcgcg ctttgcagcg ggtttacatt tctgcttaca atcgtttgca 2458201 gggcgacaat aagctgagag gcgccgataa ttggatcaaa accattatgc ggcaatgctg 2458261 catgagcacc tttcccttct atctctactt taaatcggtc aacagcagcc ataagcgggc 2458321 ctgtttttaa ccctacagtc ccaaccgcga tatccggttt attgtgaagg ccaataaccg 2458381 catcaatgcc atccagttgg ccgtcctcta tcacttttgt agcgcctgca cccgcttcct 2458441 ctgctggctg aaataataaa cgaatctttc ctttcagact gtcttgattt tccttcaata 2458501 aaaaggccgc accaagaagc gctgccgtat gaaaatcatg accgcacgca tgcatgatcc 2458561 ctttatgttt agacgcataa ggcaatcctg ttttttcttc aattggcaag gcgtcaatat 2458621 cagccctcaa agcaatcgcc ggaccttctg actcccctgc tatgtctgcg aacacacccg 2458681 tttttagagc agtagggcga atctgtatcc ccttttcttt aaggcatttt tttataaaag 2458741 cagttgtttc aaattcttct tttgacagtt caggatattg gtgcaggtgc cggcgaatgc 2458801 cgatgagctg cttttctagc gttgagagat ttacgggatt agactcctct ttcaacgtca 2458861 ggatgtcatt tcctgtagtc tgatatggat aggagccttc tatatttctc caataatcca 2458921 aagacatatg ttccgctcct ttccctatcc caatatattt tcttcagact cttcaacata 2458981 agatgaaata aatcggttca atttatcagc aagaccgccc gccccaaatc ttatatactt 2459041 gctggaaact ttcggattat cttctttcaa aaagcttaaa aaagataaaa tataaatgcg 2459101 cctgtaagct acttgtgtaa ttccgtactc aaaaaaccag ttatcaatga cattgtatac 2459161 gcctcggttg acgccatata ggttattaca tttcttgtaa aagcagagat ccggaagatt 2459221 taactcctga tgggaaagaa ggctttcttt tttgtttggt gccataatcc caatcagctc 2459281 aaagcgtttt gcaacgcacg aaatatcctt tttaatttgc tttgttaaag actccaaaga 2459341 atcaaacctt ctttcttctc taattttaaa gagaatgctg cattcgattt tttctccata 2459401 aatgtctcta tgaaagtcaa acaaaaaaat ctccaatgtc ttttcaaggt tagagcccac 2459461 cgtcggtttc acaccgatat tcataacccc taaatgaaat tgatgattga ctgtcgccag 2459521 aaccccataa actccattac gcagcccatg tatttttgca tctacatttg ccgtggggaa 2459581 tccaagcttt ctgcctaatt gttttccttt cacaaccgta ccggcaatga tcgtcaaaaa 2459641 agtcagcctc ctctctcagc ttccgcattc gatcagacga aacctaatga tgtgatgaat 2459701 gtaaaacgga ttgatgctgc ggaatgccaa gaccgagatt ttcccgcaat gtcccgccgc 2459761 gataatcttg acgataaagc cctctttctt gaagaatcgg aatcaccttt tctacaaaag 2459821 catcaagtgt tcccggtata tccgacccaa cgataaaccc atccgccgcc tcagcgttga 2459881 accaagtttc aattaaggat gcgacacgct ctggtgttcc gatgaataga gtccgtggaa 2459941 aagccatttc ctgtgctacc tcccgcaatg tcagatttct ggcttttgct tctctcttaa 2460001 tccggtctgt tgtgctttga aacgcattct ttcccacatc gccaatatcg ggaaatggct 2460061 catccaacgg gtaaacactc agatcataat catcaaaaaa acgggccaaa taagtaacag 2460121 cattttcaat cggtatcaat tctgcaaatt cacgatactt cttttccgcc tcttcttccg 2460181 tatctgccac aatcgggctg atccctggaa aaatccgcac acttgaagga tcacgccctt 2460241 catcagcagc tcggcttttc acatccgcat aaaacgcttt tgtctcttct aatgaattgg 2460301 aatgggtaaa aatcgcatcc gcatttttag cagcaaactg ccggcctgtt tctgatgaac 2460361 ccgcttgaaa cactacaggc tctccctgct tagagcgccc gatattcaag ggcccctcta 2460421 cttgaaaata ctttccttta tgattcaggc gatgaagctt cgcctgatcg aaaaactgcc 2460481 ctgttttctt attgtgtata aatgcgtcat gctcccagga attccacagc ccgcgcacaa 2460541 catccaaatg ctcttgtgcg atctcgtaac gttcagtgtg ttctggcaaa ttagacttac 2460601 tatggttgcg cgccgctcct tcctgcggcg aagtaaccag attccagccg gccctgcccc 2460661 cgctgatatg gtccagcgac atcaattgtc tggagatagt gaatggctca gtaaaagatg 2460721 tagagaacgt ccctactaaa ccaatatttt tggtaaccga tgccagcgca gataaaatgg 2460781 tgatcggttc aaaacggttt aaaaaatgag gaatcgattt ttcagaaata aataagccgt 2460841 ctgcaatgaa aataaaacta aacaaacctt tttcagctgt ttgcgccttt ttcatgtaaa 2460901 attcaatatt cgtgctggcc gagggatcaa catcgggatg acgccagccg tcagttgttc 2460961 ccccgacacc gtgaatcatg gctccaaact gaataaaatc tgcacgtgtc atctttttgc 2461021 ctcctttatc tgtgcatgat tagcaagtgc aagatcaagg tgttcaatgc cgatttcagt 2461081 tatcccttga tactgattgc cgcgcccgat ttcgaccaca ggcacatggc gcaccccata 2461141 tttcacctgt aaaatatccc gaagcttttc tttctctgaa acatcgatat tttggaacgg 2461201 gaaccctttt tcattcaaat aattcttgac ttcctcacaa tacgaacagc cttttttact 2461261 ccaaaccaca atgttcacaa catcactcat tcttctgtcc ctccttaacg ttttgcagct 2461321 aaaactgcat cgctcagcag ctgataagac agctgttttt ctacagcatt tttgatcggt 2461381 gtaaaaataa caaaatcatt gattttgtat gtgcctgata aacgtgttaa ttcttctgcc 2461441 acttcttcct ttgttccggc aataatcccg gttttttgca cgatgatgtc atagggctct 2461501 gtgacgtttt ccagataggc ctcagcctgt tcgcgggaac cgacgttgac cttacgcccg 2461561 tctttcaaaa ccacttttat cgattcacgc gacacaatat gtttttccgc ttcttctttt 2461621 gtatgtgccg caaaaacagc gggggcaaga tgaaattcag cctcagatcc tggcgggaga 2461681 tgcgcgtcaa atgctcggcg ggcttccttc agcacttcct cttcaccgtt aataaagtaa 2461741 gcaaagacaa aagagattcc cagttttgca gcagaaatgg cactctctgt gcttcctccc 2461801 aatagaaaaa tacccggctt ccgatcaacc tgcggcctag gacgcaatgc ggcatagcgg 2461861 tgggtatcag gaaaatcatc ccgaacgaaa tgagtaagct cctccagttt ttcatcaaac 2461921 tgacgcaccg gttttttata ttcggcctgc agcgcgtctg tggacagctg aaacccgccg 2461981 ggcgctttgc ccactccaag atctatacgg ccgggagcta acgctgatag aagatggaat 2462041 tgctccgcta ctttataaga gctgtaatgc tgcagcatca ctccgcctga tgctaaacga 2462101 atttttcttg tgcttgcagc aagatagcct aaaagaacct cgggtgcaga ccctgcaatc 2462161 tcatcattgt tgtgatgttc ggccacccaa aatcggtgat atccacattc ttcagccatt 2462221 tgtgccaatt tcactgtatg ctgtaatgta tcagctgctg tctccccttc accaatcaag 2462281 ctttggtcta aaatacttaa gcggatcata tcaccggctc ctttatgtgt tcttttggtt 2462341 caaataaata ttccggcgaa acacggcgga gaaactgcct cgttctgtct tttttggtat 2462401 ggcggaagac ttcctccggg gttccttgtt caacaatgac tccttcatcc ataaaaacaa 2462461 cttgatcaga gacccttctt gcaaactcca tttcatgtgt aacaacaatc atggtggctc 2462521 cggttttcac gatttccagc attacctcaa gcacttcacc gaccagctcc gggtcaagcg 2462581 ctgccgtcgg ctcatcgaac agcagcacat caggatgaat ggcaagcgcc cttgctatcc 2462641 ctaccctctg cttttgtcct cccgataact gactcggata agcgttcaat ttatcttgaa 2462701 gcccgacctt tctcagttca ttttccgcta cggcatacgc gtcttgtttt ctcattttcc 2462761 gggcaatcgt caagccctcc atgacatttt caatcaccgt tttgtgagca aacaggtggt 2462821 attgctgaaa taccattgcc gtctgttttc tgagccagtg aacctctttt ttggacggaa 2462881 agcggcaatt aatcactttg tcatgtatag aaatgatccc ttcgtctgga cgttctaata 2462941 aattcaggca ccgtaaaaag gtggttttcc ctgatccgct cggcccgata atcgtcacaa 2463001 cttctccctt gcgtaccgtg agatttatcc cttttaatac atggtggatg ccaaactgtt 2463061 tatggatatt tttaatctca atcataaagt gcctccttga aatctggctg cctttctctc 2463121 taatactcca tttgcggatt ctaggattag agtcagcacc caatagataa tcgctgctcc 2463181 gataaacgct tctaaaaatg cataattatc agaagcaacg atagtcgccg tccctgtaat 2463241 ctctgggaca gccactatag ccgcgataga ggtggtatgc aaaaagccga tacccaaatt 2463301 tgtgaagttt gggatggaaa ccttcagcgc ctgcggcaat attacacgcc gaaaggtttg 2463361 gctgtatgtc aagccgattg aataagccgc ttcgacctgt ccggtatcca tcgccagaat 2463421 gcccgaccgg atgatttctg tgagataagc tccggcagtt aaagacaagg ccatgatgac 2463481 aaacatggag accggtatct cattagcgga ccagccgaga tgaaaaaaac tgctgacttg 2463541 atctgcaaca ggcggtatcc ctaaataaat caacataatg tgaagaattg caggtgtact 2463601 tcgaaagaaa gacacataaa accttgagca agccaccaag cccttaattc taaaaattct 2463661 aacaattata tttccaagag ccacgagaaa tccaaacaca atcggcaaaa cagccatcat 2463721 caatgtcaga ggaatggtct ttaccatttc tttcatggcg gaaacgataa atggaaagtc 2463781 aaattgcaat cttctccccc ctcatccgaa gaaatatatc aatgtatgtt catgtcaaaa 2463841 acagtaacaa tccttgtttg attcttcttg attcgttttt ctgccactcg aaagaaccat 2463901 tcgaataaaa ccgctacagc ataataaaca atcgatagcg caatgtaaac ttcaagagaa 2463961 tggttgcttg aggtaatcag tgtttggccc cttccggaca tatccataac acctattgaa 2464021 aaggctagag acgtatcttt taaagaactg atcaccatgt ttcccatatt cggaaacgcc 2464081 tggacaagtg cctggggcag aacgattcgc ctgaaggcct gactaccgct taagccaata 2464141 ctgtacgccg cttccgtttg gcctttatct acactgccca cccccgctcg aatgatttct 2464201 gcggctgccg ctgcattgct taacgcgtag gttgcgacag cagcataaaa cgggtccatt 2464261 tttgatgtat caatcccgat aagccccgta agcgccggga tcccgtaaaa cacgatgaaa 2464321 agctgcacca tgataggcgt tcccctgaaa aacgagatat acacttttgc caattgattt 2464381 acaattggaa tattatagat gcggggcagt gccagaaaga gtcctaatac aaaaccgaaa 2464441 agcaaggaca gtgttaaaat gtataatgta accggtaaat aagcggttaa cgtcggcaca 2464501 aaatctccaa tcatgttcat atcaaacgct ttttccatca ctgctccctc tctttttacc 2464561 taatactgct ctttggaata gtcgtcacca agccatttca aactgagcct tttcaacgtt 2464621 ccgtcatcaa tgatttcctg taaggcttta tcaatatcgt cacttaacgt ttgttcattt 2464681 ttgttaaaca taaaatacac tttggcattt gaaagcacat taccgacggt tttttcttta 2464741 atagtgctcg tcttgttttg aaagtctact gcaaaaggcg ttgagatcgt tgcgtccgca 2464801 cgccccgatt tcagctgatt cgcagtctca tttgcgcctt ggccctcata ggcaatctca 2464861 aacggccgtc cattatcctc attccatttt ttcagtacaa gcgctccgtt ggaggttgca 2464921 ctcgtaatca cccgttttcc ttttaagtct tcaattccac ggatcgtatc gttattttga 2464981 agcacagtaa tttttaaagg aaaatggttg taagcaacct tgttaaacag aaattttttc 2465041 tcacgctctt tgcttttctc catttgatgt gccacgatat cgactttatg ctgtccgagg 2465101 ctgacaagca ggttggaaaa ttccatcgtt ttaaatgtga atttataatg tggcaggcgc 2465161 ttatcaagct ctttgatcag ttcgacatca taaccggtta aatcgccttt ttcatcgata 2465221 aagcaaatat tcggaaattg ggttccagtt ccgaccgtga tcgtctgtac cttcttttgc 2465281 ccggctcccg tcgtttgact gcctgcaccg caagctgaca gaactgttat aagcgaaaat 2465341 aatattgcca tgaatgctgt tttcgttttc atctcatcgc cccatttatt tttcaaaact 2465401 tgattttgaa taatctgccc cgagccattt tcggcttagt ttttttagcg ttccgttttt 2465461 ctccagcttt ttaatcgctt gatccgtgtc atccgccaag gtttggctgc ctttattaaa 2465521 cataaagtac acctcggtat ctaataacac gtcaccgact gtcttttggc ggaaggcgtg 2465581 cgttttattc tgaaaatcga cggcaaacgg tgtagctatc gttgcatctg cgcgcccggt 2465641 ttcaatttga ttggcggtat cattgcttcc ctgtcccgca tatttcaaat gaattgggct 2465701 gccgtgcgtt ttgttgtact ttgtaatata atctgccgca tttgacgtgg cgccaactat 2465761 gactgttttt ccgtgtaagt cttttaatgt atgaatcttg tgattatcct ctttcaccgt 2465821 gatgtacatc ggcgagtagt tatatgggac tttatgatac aaaaaacgct tttctcgttc 2465881 tttatttttg gccatattgt gcgcaatcac atcaattttt ttatttccga gactcgtcag 2465941 caaatttgag aaatccatcg ttttaaattc aaatgtatat tgaggcaact ccttatcgat 2466001 ggctttcatc acttcaatgt catacccggt caattcacct ttttcattta aaaacgcaat 2466061 attcggaaaa tctgttccag tgccgactat gaccgtttga gcctgacgat ctgttttgtt 2466121 atttgtttgc gaacatcccc cgccaagtaa tgcaaacact gacagcagca aaaccaatcc 2466181 tttacgctta ttcataggct gcctcacatc atgcccagct gggcgcacct aaaagcgttg 2466241 ggttaaatcg ttccggaatc agaaccttgt gcatcatcac acctatgtcc ccgtcttttt 2466301 cctgctcaaa atacacttca taccctctcc ttctgtacat gtcagcaagc caaggatgct 2466361 tgcgcgccga tgtgccgagt gtcagcgcag gagccttcag catatctcga agcacttttt 2466421 cttcaacata cgtaagcagc ttacttccgg cgccttgccc tttatattcc ggcagtgtcg 2466481 caaaccacca cacaaatgga tattttgaag gaggcgtctc actctcccac gggaacctga 2466541 ttgtaatcgt tgaaatcagc ttcccatccc gctccagcac aatcgctgaa tgatgttcaa 2466601 tattttctga taccatttgg atatcagctc tcgtggatgg ccaatcaata tccagctgcc 2466661 gaatgggctg aaatgcgctg ttaaccagtt tcaacagctc cgatgcatct tcaacagttg 2466721 ccagtcgaaa aatatcatca ctcatttttg tcactcctct tcacaaaata tataattcct 2466781 atttgtttac taagctttta ttgtttatac tataaagcat actctgatct ttgactaatc 2466841 aaaaaaagta aaccttcact tcagtaattt taatgatgaa aaacaggagg gagcacattg 2466901 gagttacgct caatcaaaac gtttcatacg attgtaaaat ttggaagctt ctataaagct 2466961 gcagaaatac tcaactactc gcagccgacg atatcgatgc gtatgaagca attggagcag 2467021 gatttaggcg tactgctgtt tgaaagagga aaaagcctgc agttgacaaa agcagggaag 2467081 cttttttatg aacgaacagg agatcttttg atgcaatacg aggcgcttaa acacaacctc 2467141 tccgacttaa aggaagaaga ggcaggcatt atcaacatag gggtttcaga gccaaccgcc 2467201 agtctgatat tccccgagat tttaaaggat ttcttaatgg attacccaaa gataacggtt 2467261 aatatcaagg ttgatgacgc caatacctgc agtcaaaagc tcttagacgg gacgattgat 2467321 tttgcagtct gcggcgagcc ggagctgatt cttgaaaatt actaccatcc atttttttat 2467381 gacacattaa atgtgattgt atctgatcaa catccgctcg ctgagaagaa ggctgtccat 2467441 ttgtctgatt tagcagaaga gcgcttcata tttacgcccg ccaattgccc cattcgctta 2467501 caaattgaac agcatttaca tagagaactc gggaatcgct acaaaaaaat ggagctcaca 2467561 agcagcatgt cacatgaata ttacgtacgt gaaaacatcg gaatttcaat ctttaccagc 2467621 accgcacatt ctaaaccgtt caacggcact aaagtcattc caattctgaa cctggatatc 2467681 accccgccca tagggctgtt gacaaatcaa aaagaagttc attttgaccg cgccacgaag 2467741 gacttgatcg cccggataac caaacgtttt cagcagcgca gcaaagaatt ggaaggaacc 2467801 tctgataaga ccattacagg ataactgaaa aaataaaaac cacctcctga ttcatcagga 2467861 gatggtttca cggtttaaag ctcgatcgtc tcaccgaccg acatgacttt gccgactccg 2467921 cccggcaggc tgtcagcgaa tgcttctggg tcttgttcga tgaccgggaa tgtattgtaa 2467981 tgcaccggca cgacctgttt tgcgcgcagc cattcagcag caagcttggc gtcttcaggc 2468041 cccattgtaa agttatcgcc aatcggaagg aaagcaaggt cgatatgatt caattcgcca 2468101 atgagtttca tatcagagaa aagtgccgta tcgcccgcgt ggaaaatcgt tttatcttct 2468161 acagtcagca aaataccggc aggcatgcct gtgtaagtga tcgttttgtt ttcttcatct 2468221 gtgatggctg atccatgaaa ggcctgtgtg agcttcactt ttccaaaatc gaactggcgg 2468281 gagccgccaa tatgcattgg atgaacattc aagcctttcc agcctaagta cacagcgagc 2468341 tcgttcgggg ctataaccag cgcgttattt tgcttggcga tttgttcagt atcaccgaca 2468401 tggtcattgt ggccgtgcgt tagtaagatg acatccgctt ttacatcctc cggctttata 2468461 tccgttaatg aattccctgt taaaaacgga tcaaaaataa tatgatggtc cttcgtttcc 2468521 actgtgatta cagaatgtcc gtgatatgtc actttcattt ctttcacctc gtcacatgat 2468581 tttgtttttt ttattttccc tttttaaaaa gctgaaaaac ttatgttgtt tgattcttgt 2468641 taatgacatt gaggcctccg gtggcttcaa tgacagtccc tgtcacaagg tctgagttct 2468701 cctcacacaa gaaagcgata atcctggcaa tatcctcgcc tgtaccggat cttcctatcg 2468761 gcgttttttc tttgccgatt cgcattctgg cttcctctat cgatgcttct ttcatgtcgc 2468821 cgacaatgtc tcctgggcaa accatgttgg cggttatgcc gaattcggct tcttcaatgg 2468881 caattgtctt cgtcaaagaa gccaagccca ctttcgcagc gccaaatgcc gatcggtgaa 2468941 gccagccggg cgcgtgagcc gcaccttgga atccgtacgt aataatgcgt ccaaattgct 2469001 gttttctcat aataggaata accgctttga ataaatgaaa gacggcgctt aaatttcctt 2469061 ccagcatgcc ataccattca tcatcagtat aatcggctaa ctttttacgt tcaaatatgt 2469121 atggtccagc gttgttaatc aaaaagtcga tccttccgaa gcggtttaag gcagcctctg 2469181 caatacgcag cagatcttct tttttggtga catcaccttt tacaaattgc agccggtcaa 2469241 gacaatcggg acaggcttcc ttcaggcggc tgactgcctc ctcatcctgt ctgtaattga 2469301 ctgttactga ataccccttt gcaagcaacg tttcagtcac tttgcggcct aaacccttcg 2469361 aaccggcagt aattaaagca tgtcgcacat gaatacctcc caaagcaacg tcgccgcttt 2469421 caataaagtg tttcttcttc tactttacta taaaaggctt gcaatatcac tttttacact 2469481 ttggcataca aaaaaagctg cctgtacaga cagcttattc tgcaggagat gaagactcct 2469541 gatcaggcat atcgacataa ccgctttgat atgcttctga aatgagcctt gttgtctcct 2469601 ggctttcttg ttcatcataa atatagcgtt ccggttcttt tttcatcatt ctgcctccca 2469661 tcattataga ggtaggttgg ctataatgac gggattttat gaaggaaatt ttaacaaact 2469721 cctgctgcca cgcaagcttt cgctttttca agcgcctgtt ccacctgttt gaatccggtg 2469781 cccccggcgc tcattctttt ttcaactgcg tagtaagggt ctaacacagt gtaaatatct 2469841 tcttcaaata gtgtgctcgc ctgctgaaac tcgccaaacg gcatatcgct taaatagatc 2469901 cctctttcga tgcatgtgta cacaagtttc ccgaccactt catgcgcttc tctgaacggc 2469961 attccttttt tagctaaata atcggccagt tccgtcgcgt ttgaaaagtc ttgttttgtt 2470021 gcttgcttca tgacgtcttt gtttacagtc attgtttgga tcatgcctgt gaagatttgc 2470081 aggctgccct ccaccgtttt caccgtgtca aacatgccct ctttgtcttc ctgcagatct 2470141 ttgttgtaag cgagcggaag tcctttcatg atcgtaaaca gccccatcat atcgccgtat 2470201 acgcgtcctg ttttgccgcg gatcagctcc gccatatcag ggtttttctt ttgcggcatc 2470261 atgctgcttc ctgttgcgta cgtatcgtca agctcgatga atttaaactc ctgcgagcac 2470321 cataaaatga tttcttcaga gaaacgggat aggtgcatca tcagcatact gctgttgctt 2470381 aaaaactcca aaatgaagtc tctgtcgctg acgccgtcca agctgttttc ataaatggca 2470441 tcaaagccga gcagttccgc tgaataatca cggtcaattg ggaaggttgt tcccgcgagc 2470501 gccccgcagc cgagcggaga tttgttaatc cgcttcattg aatcctgaaa acgctccttg 2470561 tcgcgctcaa gcatccagaa atacgcaagc agatggtgag cgaatgaaat cggctgggcg 2470621 cgctgcaaat gtgtgtagcc cggcagaatc gtttcaacgt tcgcttccgc cttttcaatc 2470681 agcgcacttt ggaatgcctc aatcagctcg atgatgtggc cgacatgatt cttcaagtat 2470741 aaatgcatgt cagtcgccac ctggtcattc cggcttctgc cggtatgcag cttgccgcca 2470801 agaggaccga tttcgtcaat gagcattttc tcaatgttca aatgaatatc ctcataatcg 2470861 actgagaatt ccaatgctcc ctcctctgct ttttgcaaaa gggtattcag gccctctcgg 2470921 attttcaact cttcttctgc tgtcagaata ccgcattttt tcagcatggc agcatgtgcg 2470981 agagaccctg taatgtcttc agcaactaaa ttttggtcaa atgatatgga cgcgccgaac 2471041 tcgtcgaccc atttttccgg tgttttttga aatcggcctc cccaaagctt cttcatgctt 2471101 taatctgctc cttctttttc acgatgctgt tcacttttgt cggaagtccc caaagctcga 2471161 taaatccgat tgctgcatgg tgatcaaatg catcgtcttt tgtatatgtt gcaagttttt 2471221 catcatatag agagtattcc gatttacgtc cttctacaat tgcatggcct ttaaacagct 2471281 tcacgcggac aatgcctgtg acatgctttt gcgtttcttt taagaaagcg tgcagcgcgt 2471341 cttttaacgg tgagaaccat aagccgttgt aaatgatttc tgacattttt tgctcgatga 2471401 tcggtttaaa gtgggctacc tctttcacca gtgtcaaatc ttctaattct ttatgcgctt 2471461 tgatcagtgt catcgcacca gggcattcgt atacttcccg ggatttaatg ccgacgaggc 2471521 ggttttccac gtggtcgata cgtccgacac cgtgcgcgcc cgccatttca ttcagcttca 2471581 agatcagctc agaaagcgag taggaaacac cgtcaatgga gacaggcacg ccctgttcaa 2471641 atgcaatttc aatcacttcc ggcgtgtccg gcgttttttc cagcggagct gttaaatcgt 2471701 atgcaccttc tggcggcgcc gcccatggat cttctaaaat gccgcactca ttggcgcgtc 2471761 cccagaggtt ttggtcgata gaatacgggc tgtcaagatt gatcggaatc ggaatgccgc 2471821 ggctagccgc atattcaatt tcttcttcac gtgaccactg ccattcgcga accggcgcga 2471881 tgacttctag gtcagggttt aatgatttaa tggagacttc gaaacgaacc tggtcatttc 2471941 ctttccctgt gcatccgtgg gcaatcgcct gtgcatcttc tttttccgca atttcaacca 2472001 gttttttcgc gatcagcggt cgagataatg ccgaaacaag cgggtatttt ccttcataca 2472061 ttgtgtgggc ctgcaaagag ataagcgcgt aatcctgtgc aaattcttct tttgcatcga 2472121 tcacgtagga gtttgtcgcg ccgacttcaa gcgctttctg ctgaacaaat gccaaatctt 2472181 tgccctcacc gacatccagg cagcaggcga ttacattata tccttgctcc tgaagccatt 2472241 ttattgcgac ggaagtatca agacctcctg agtatgctaa tacgactttt ttctgttctg 2472301 acatgataaa aatcccctct caaccgtgtt tctattttgt ataaaaataa attatattta 2472361 ataaaaatac attttgtatg tatacacttt aacaagtacg tttcgttttt tcaagccttt 2472421 tataaaaaaa acttcaccta aatttcaggt gaagtttcat agtatttatt catttacttg 2472481 tcttttctga tttctctgac cacatgcgca agttcgggaa taatcagctt attcattgcc 2472541 agctttactg cgccgcttga gcctggcgtt gagaaaacag cggtatgctg aatgacgccg 2472601 gcagttgctc tcgacatgat tgcggcagag ccgatatcct ctgtataact cagcatcctg 2472661 aatatttctc caaagccggg cagttctttc gaaaacagcg gcgttatggc ttcaattgtg 2472721 acatcccgat ctgctatgcc tgtccctccg tttaagagta ccgcgtctgt ctgttcatcc 2472781 atgcagcccg caagcactga ccgttgcaaa gcatcctttt cgtcttttac aatttcatat 2472841 gcggcaatat gatgaccggc ttcttctaaa aatgagatca tcagcttgcc gcttttatcg 2472901 gtttcatctg tcctcgtgtc actgacagta atcactttgc accgaacgat atcgggagct 2472961 tcttgtttat gctcttgaac gctcattggc ccacctcttt tatgttttct gtctgtcact 2473021 atcatgcatc aacaaaaaag cacattcaag agaatgtgct ttcatgcgat ttattttgct 2473081 aaacgaacaa cgtcgcgcgc aatcatgact tcttcatcag tcgggatgat catgactttt 2473141 actggagaat gcggatagct gatgaaagct tcctcgccgc gcacgttatt aagcgcaggg 2473201 tcccagtata cgcccatgaa ttctaaaccg cgaagaacgc gttctctgac ttccacactg 2473261 ttttcaccga taccggcagt aaagatgatc gcatctacac cgctcattct tgcagcgtaa 2473321 gaaccgatgt atttgtggat tctgcttgcg aatacttcaa gagccgtttc cgcgcgctca 2473381 tttccttctt tcgtagcttc aacgatgtca cgaagatcgc ttgagaaacc ggaaatgccg 2473441 agcagtccgc tttttttgtt taatgtattc agtacttcgt cagccgtttg gcctgttttc 2473501 tccatgatgt atgggatcag ggcagggtcg atgtttccag agcgtgtgcc cattgctaca 2473561 ccggcaagcg gcgtaaagcc catggatgtg tcaatagatt ttccgccttc aacagcggca 2473621 atacttgctc cgtttccaag gtggcaggaa atcaggcgca agtcttttaa cggacggccg 2473681 agaagctctg ccgcacgctc agttacatat ttatgtgaag tgccgtggaa gccgtattta 2473741 cggatgccga atttttcata gtattcatac ggcaagctgt aaaggtaaga ctgctcaggc 2473801 attgtttggt ggaatgctgt atcaaataca gctaccgcag gaacatttgg aagcacttct 2473861 ttgaacgctt taattccaac gatatttgcc ggattgtgaa gcggtgccaa ttcagaaata 2473921 tcttcgattt ccttaatggt ttcatccgtt aataaaacag aatcgctgaa tttttctccg 2473981 ccgtgaacga cacgatggcc aattccgtca atttcattca agtctttaat aatgccgaat 2474041 tccgttaact tattcagcag cattttaaca gctaccgcat gatctggaat atcagttact 2474101 tctgtatttt tttcgccgtt cacagaaatt gtgaatacgc tgtcggcgat accgattcgt 2474161 tcaactaaac ccttcgttaa aacggtttct gaaggcattt cgaaaagctg aaatttcaaa 2474221 gacgagcttc ctgcgttaat tgcaataatt ttggacatga ttgacgctcc tttatactct 2474281 gtatcaacaa cttcgttttt cgtacttttt tcccggtgaa tatcaacatc ttctccgaaa 2474341 aatatctgac ttttccattt aaacattgtc atgtcggctt ttcaagtcaa cttgcgtatt 2474401 gataacgctt acaataagaa gtcgttattt tcagacacat tcactatagg ttttgtattg 2474461 atgaacgctt acaatttgcg gtttttccct ctgtattttg tgtttcaaag ctggattcaa 2474521 ttcgtcaagt ccggtcttca aaagcataaa taaaagcagc ttaggcatcg acctcatacg 2474581 gctgtctaag ctgcttttaa aacacttact tttctttttt aaaccattca tcaaattgag 2474641 ccatcatatc aagcatcgcc ttttgattgg agaaagacgg aagattcgca agcagaattt 2474701 gccccggcgc tttcgtattc tctccttgtt tctgaagcac aaggatgctt ttggcatgag 2474761 cttcgtcttt aaaaatagat tttggcagct gcaacagtgc gttgatatga accttatctt 2474821 tgaaaaactg tttcagcttg ccgctttggg agctctcaaa caaatgattc ggaatcataa 2474881 aaaataagta gccgcccggt ttggtatgct tgacgctctg ttcaataaac agatgatgag 2474941 cgaaggaatg gccttcgtca gctttgagct caaacgcttc tgctccttcg tcattcggat 2475001 aatagccgac tggcagatca caaatgaccg tgtcaactgg atcgataaac aacggctcaa 2475061 ggctgtcctg gtggaaaagc tcaagctctt ttttcagaag gttcgcttgg gcataggcga 2475121 tcttcaagag cacatcatca atttcaatgc caaagctgtt tgccgttttt tcagacagct 2475181 ggttcagcac ggtaaacaga aggttcccag ttcccagggc tggatcaaga atggtcagtt 2475241 cctttttgtc cgccataaat ttattcacca aatagctgat gaaaagcccg atcgtatccg 2475301 gcgtcatttg tctgtttgga tgcgagatat ctttcattcc tttaaggacg gcaagctgaa 2475361 aagccttgcg tacccactca tgctcatacg tgccgaattc cgctttttca agcagagcct 2475421 gaagttgttt ggttttctga tcagcaggca gtttcagctg atccgttttt tcaagaaaat 2475481 acatttctcc tgcttcggcc agcgcctcta tatatgaaat ctgcaattca ttctttatca 2475541 taatcgcggc ttcgtttaac agctcataca ccgcacctac atggtctttt tgcatattgt 2475601 gttcctcctt gccatgaaaa aagctccggc ggcagcctgg agcttttttc cctgcttact 2475661 ttactaatgc cttagcagcc tcaattggct tttcatagtt cgggtggttt gttgcttcgc 2475721 ttacatattc agcgtaaacg acttttccgt tctcatcaag gacaaatacg gaacgcgcaa 2475781 gcagacgaag ttctttaata tacacaccga acgcttcgcc aaatgacata tctctgtggt 2475841 cagacagtgt ttccactttg tcaattccgt tagcgccgca ccagcgcgct tgcgcgaatg 2475901 gaaggtctgc actgattgtg tagacgttga catctccaag ctttgcagct tcttcgttaa 2475961 aacggcgtgt ttgtgcatca caaacacctg tatcaattga agggataaca gaaataatcg 2476021 ttacctttcc tttcatgtca gctaacgatt tttcttcaag gctgttagtc agcactgtga 2476081 aatcaggagc ttgatctcct accttcactt cttgtccgac aagtgtaacc ggaccgcctt 2476141 tgaatgtaat ttcagccatt ataattcctc ccttttgtat gtatgtctct atcatagtaa 2476201 agtttcctgc aaactgcaaa gtttatgcca aaaaaaagtt aactgcggcc agcgcagtta 2476261 accttttttt aataattcat attgttcatt tggttttgat tttggccttg gctttggttt 2476321 ttgttatttt tcttgaacat ttgctggatg cgctcgagtg tttgaggggc tgcgtctaaa 2476381 attttctcta ttaaatgggt attttcatct aaatgaagca ttctgatgcc tgtcgatccg 2476441 acaattaaaa acgcgatcgg cgtaatggac acaccgcccc cgcttccgcc tccgaaagga 2476501 agtttctgtt ctcttgtctc atcgtcttcc gatttctttt cggccggctt tccgccaaac 2476561 tcgcttccgc ctgcggcgaa tccgaatcca actttagaaa cagttaaaat cacacttcca 2476621 tcaggcgttt ccactggatc tccgatgatg gtgttaacat caatcatttc cttcaagttt 2476681 tccattgcgg ttttcattaa accttggatg ggatggtctg ccatatacgc ttcctcctta 2476741 aactgatgaa tcattctttg aagtcattct agccgacgga ttcttcttta atacggatag 2476801 ctcccgtccg tatttgacga atttgaaagc tgcaagcata gcatgtccaa agcgaaaaaa 2476861 gaatatacac tgaaaatggg tcttggaaac agggacttga aacgacggga tcacctcata 2476921 gacaggttta ttcacaaagt ccaggtggtc gtagagcatt gctgcgatac cgcccttcac 2476981 gccccataca gcaccggtta acacacctgt cactgccgcg tcctgaattc cgattactgt 2477041 aacccattct agttttgtga tatgtaaatg cgcgagaaaa gacgcgctga ttttccgcag 2477101 tctggtgacc tgatgcaaaa gcatttcgat tttattaatg ctttgctgca catcgttttg 2477161 tgtaattttt ttctttccgc tgcttttttt cattttggat tcagtttttt gtttgatatc 2477221 cactgttccg tcttctttgt tcaccttaat cgccgggatt gtttttttga tccttataag 2477281 gccaaacagc gccgtaatct tcaaggtcaa tttgtcatta tcatcggcat gaagatactc 2477341 cagcgcgaca tggattttca ttctgagaag cagtacgatc cctatgagaa taagaatggc 2477401 tgtcagtaca tacaccatat tcttcacttc ctctaggagc attatcgcca attcctaaaa 2477461 aaataaaccc ggacggaagt ccgggttatc ggttatttgc ggtataattt ttcatgcacc 2477521 acggtggtat ccgcgatgta atcatgaatc ccttgttttg taggtgaaaa ggcaacaacg 2477581 atatataaaa tccaaatctt atcaatatac cgtccaacca cttcacgaaa aatcactgta 2477641 ctccatgtca gcttgctatc ttgcttcaca gaaaccactt tgaggccgaa caccatttta 2477701 ccaagcgtct gcctgaagta ttttgtcatg agtgcgaaat aggcaagata cacaataagc 2477761 gttgtcacac tgtaggccga gaaggtaaac atgccggatg ttttcggcag atccaatacg 2477821 gtaaagaggg gagaaacgag caaatggttt aatccccata tcacgagcca atcaagcagg 2477881 aaagcccaga aacgaaccca aaagccagca taggcatgtg tcagcagctc cgcttcttgc 2477941 gggcctttga tgtcattgcg ctctaactct tcatatgtcg cgtccattat tgttccctcc 2478001 tacttcgcat agagatacat cattctcggc gaaccggatt gcgatagaat ttctctcata 2478061 ttcaaaaaat caatttcact tttaaacatt ttgttcgcgc ccatggaaaa cagtgagcct 2478121 aatccgaagc tttcctcata agaaatgaca gaggcgtttt tcaaatcctt gtgatccttt 2478181 ttcatggccg taatggtatc gtcataaaaa ccaagctcat caacgaggtt cagttttttc 2478241 gcctgccgtc cgtcatacac gcggccgtcc gcaattttct ttacctctgc tttcggcatg 2478301 ccgcgccctt ttgaaatgac atcaacaaag ccttcatacg aattatcaac catcgattgc 2478361 atgatgtttt tttcttcttt cgtcatctca cgggaaggag acataatgtc cttatgggcc 2478421 ccgctcttaa tcgtttcaaa agaaatgcca agcttgtcgg caagctttga ataattgacg 2478481 ctttccataa tgacgccgag tgacccggtc agggtttccg gtgtcgcaaa aatcttatca 2478541 gccgctgttg agatgtaata gcctcctgat gctgccatcg aacccattga cacgtaaatc 2478601 ggttttttcg tttctttctt gatttcttcc agtttcttat gtatttcagc actttcatac 2478661 actccgccac ccggagaatt caccttcaga acgatacctt tgaccgtctt gtcatctttt 2478721 gcgcgctcaa ggttttttaa gaacgttctg tggttatatc cgtctgcacc aagcagactg 2478781 cttgagtccc cattatcctg aatggtgccg ctgacctcta atacggcaat tttacttgag 2478841 ggactgccgt tttccagcgt cttctcctgc gattcatccg tcagtgatgt gagatccgtt 2478901 tgagcgcctt tgacgctttc aaagaaactc atagagatgc tgacgataat agacacgccg 2478961 aaaatcccca gagcaatcac taatgcaatc catctttttg cattcatttt ttctcctcct 2479021 ttttcctaaa ctctctcatt atacgattca atatgaaaaa tgtttcactt catgagaaag 2479081 ctccggctta acgggctgcc ggcaaacgtg gtacacttat ggccaaaggt attttatcac 2479141 aaatactgga tggcagaaaa acttaaatat gacagcaaag gggaaatggg atatgaccga 2479201 tcaacgccgt aatgtttatt tttttcacaa acaggatcag gaaacgaacg aacaagcccg 2479261 ctcgttaaca caattagcgg aagagcatgg atttaccgtt gtgaaccagc actcagacgc 2479321 caatattatc gctagcattg gcggggacgg cacatttttg caggcagtca gaaagacgaa 2479381 ttttcgtgac gactgcttgt acgtcggcat taccaaaaag gggaaagctc atttatattg 2479441 cgactttcat agtgatgagc gagaaaaaat ggtcgatgca atgacgtttg aacaaattga 2479501 agtgagaaaa tacccgctga ttgaagtgac agtggatcaa gccagtcctt ttcactgctt 2479561 aaacgaggta tccatccgct caagcatcat caaaaccttt gtgatggacg tgctgattga 2479621 cgatctgcac tttgaaacgt ttagaggtga cggaatgatt atctcaacgc ctacagggag 2479681 caccgcctat aacaagtctg ttgcaggagc tgttgttgat ccattgcttc catgcatgca 2479741 ggtatcagag cttgcatccc ttaacaataa tacctaccgg acactcggct cgccatttgt 2479801 cctcagctct gaccgaaagc tgacccttcg tgtggtgcag gacggcaacg aacacccaat 2479861 catcggcttg gacaatgaag cactcagcac gagaaatgtg aaaacgatcg aaatcaaact 2479921 gtctaataag aaaatcaaaa cagtcaaact aaaggacaat tcattttggg aaaaagtgaa 2479981 gcgtactttt ttatagaaaa taaaaggaca ggctgctgcc tgtcctttta tgatttctca 2480041 tatacaatct ggccgttaat cacggttttt ttaatctcta aaagatgaag ctgtgcgggg 2480101 tcaatggcaa acggatcacc actgagaact gtaaaatccg cgtcatagcc ttccgcaatt 2480161 tttccgcgtg acttctcttt ataaatgata ccggcgctac cttctgtata aagctttatc 2480221 gcttcatata caggtaaaca ttcactttca ttatagcttg gcccgttttg ctcatgactg 2480281 cttttccgga ggaccgcgga ctggatccct agaagcgggt caacaggctc aatcggggcg 2480341 tctgaaccgc ccgcgcataa aatgccttta gatatgaggg ttttccaggc aaatgcagtc 2480401 ttcatccggt cttttccgag acggtcaatg acccacggaa agtcgcttgc aacgaagtgc 2480461 ggctgaaggt caagtgcgat cggcatgcgt gctgctctct cgattaattc gttatcaagc 2480521 acttgagcat gaataagccg atcatgccgg ccgtttttgg gcggatgctt ttctattgcg 2480581 ttcagcactt tttcaaaagc aagatcgccg attgcatgaa cagcaacctc catccctttt 2480641 tctctcgctt tgcgaatgag ccggccaagg gtttcgtcat cgtgaacctg aacaccattt 2480701 gttgatggat catcctgata tggttctttc aataaagccg ttctcccgcc aagcgccccg 2480761 tccgcaaaga ttttcatagc accgaactcc acatacgggc cggacagctt ctccagctgc 2480821 tcccatcgat cgacagcttc atgatgaacg agcaaatggc agcgaaacgg atactttccg 2480881 ccagcggcag ctttctcata agctttcatc ggcaccgaaa catcaccata ataggacaag 2480941 tcttccgaat gaccgcccgt caggcctttt gtccagcaat cctttattgc agccgttaat 2481001 gcctcatcaa catagtgctg ggagactggc gggacagcct tcagaatcaa atcctgcgcc 2481061 ttatcaaaca ggagtccggt cggctcgcca tttgcatctt ttacgatgac tccgccgtca 2481121 ggatcaggag tatttcttga aattcccgct gcttgaagag ccgcagaatt gacagctatt 2481181 gcatgccggc atatacgctt gagcaagacg ggcctgtcag gaaacaggcg atcaagatca 2481241 tgcttagtca agtagtcagg tgtctcaaac tgattttcat tccagccttc tccaatgagc 2481301 caatcgtttt taggaagctg ccgctctctt tccttcgcag cctgtaaaat tgaatctttc 2481361 gacgtcagtg cggacagatc gagctgaagc tgtttctcac cgtggccgat caaatgtaga 2481421 tggctgtcaa caaaaccggg gaacatcact gctccgttca ggctgatttc ttctgtttcc 2481481 ggcgacccgt acttttcctt caaacgttca tagctgccgg tgccttttat aacaccatcc 2481541 tcaacataaa ctgcctcagt ccgatcgcct tcttcgagca tcgtataaat gaaaccgccg 2481601 tgccatatcg ccttcattca cgttcactct ctttctttac gcctttttat tggctttgag 2481661 ctgttcttca cgttttctta attccactcg tctgattttt gcagaagccg ttttcggcag 2481721 gctttccaca aattcaattt ctctaggata tttgtatgga gcggtaatcg tcttcacatg 2481781 gttttgcagc attttgacaa gctcatcact gcgtttttca tgattttgca ggacaacata 2481841 tgcctttacg atggagcctc tgatttcatc agggcttgcg acaacagcac attcttttac 2481901 ttctgggtgc ttaacaagcg cgtcttccac ctcgaaaggc ccgatcgtat agccggagct 2481961 gataataata tcgtcatttc ggctttcaaa ccagaagtaa ccttcctcat cttttcttgc 2482021 tctgtctccc gttaggaaat aatcgccgcg aatttgtgtt ttcattcttt ccggatcttt 2482081 aaaatactct ttaaagagcg caggcgtact gaggtgaaca gcgatatcgc caacctcacc 2482141 aggtttgcag atttcaccgt cttcatttat gatctccacc tgatttcccg gtgtcggttt 2482201 tcccatgctt cccggtttaa taggcgtatc tttcaaaaca ccaaccaaaa gcgtgctttc 2482261 tgtttggcca tatccgtccc gtaccttaat gccaaagtgc ttttggaaaa catcaatgac 2482321 ttcacggttg agcggctcac ctgcggaaac agcgctgtgc agggcagaaa gatcaaagcg 2482381 tttcaagcct tcaaccttcg ccattaagcg gtattctgtc ggagtgcagc agaaaacatt 2482441 gattttgtag cgatttaaaa gctctagata tttttctgct ttgaatctgc cgtggtacac 2482501 aaaaccggtt gctccgctgc caagcaccgc taaaaacgga ctccataccc acttttgcca 2482561 gccaggggca gcagttgccc agacgatatc cttttcagaa atgtcaagcc aagcgccggc 2482621 agaagttttt aaatgagcaa atgcccatcc atgtgtatgt acaacacctt tcggctgacc 2482681 tgttgtcccg gatgtataag ataagaaagc catatcatct cttgttgtgt cagctgtttt 2482741 aaattggctt ccgtccgctt caattgataa gaggtttttc cagccggcat cattttcacc 2482801 aatagacagt gtaatcagtt tgtcagccgt actgacatcc cggaaagcgc caataaattc 2482861 ggagtagacg atagcgcctt ttacctctgc atgttcaatc cggtattcaa gatctttcgc 2482921 gcgaagcatt tcggagcacg gaatgacaac cattcctgat ttcaggatag ccaaataaac 2482981 agcataggct tcaagcaccc gcggaaccat tacaatcagc ttgtctccct ttttaaatcc 2483041 aagatcagct aaggccgctc cgattttatt tgtttcttcc atcagctttt catacgacca 2483101 agattcttgc ttgcccgact cgtcctccca aagaagagcg gttttttgtc cagcagcact 2483161 gaacttttcc atttcattca ctaaattata ttgcacaggg gcaattaaat cttcacgttt 2483221 taacacgaac aactcctcac tttctccacc cattatacat aaatacaggc tctttccgta 2483281 aggatatgcc taaaagcaac ctctgtaaac atagatttta taggccgctg gtcctttttt 2483341 atatgtaaaa aatgaaaaag agtggggata cccccactcc taagccatta tgtgaaattg 2483401 taaattagaa ttgtcctccg cccatgtttt gttgagcaaa agatacaaga cgttttgtga 2483461 tctctcctcc aacagaaccg ttagcgcgag aagttgtgtc tgctccaagg tttacaccga 2483521 attcagaagc gatttctaat ttcatttggt cgatcgcttg agcagctcct ggtactaaaa 2483581 ggttgttgct gttacctgag ttattgttag ccatgtgtct cacctccttg tgagtataga 2483641 atgtgtcaaa acacatggct tcattcagaa aaactttggt aattgtatac aggagctgaa 2483701 aattgattta aaagagttca gcgaatttat cgttagcttc ttgttcgcta taaagggtca 2483761 ttgtctcaat gttatctacc gcttcttgaa tatacggctc gaaatcaaca aagctttcaa 2483821 agtgttcaat tttctctttt ttagggcgtg ttttcgggct tggcggtgta aagatcgtgc 2483881 agcagtcttc aaacggctga atacttgtct catatgtgcc aatttcccgt gatttttcga 2483941 tgatttctgt tttgtccatg gcgattagcg gacgcaaaat cggtgttgac gtcaccgcat 2484001 taattgcata catgctttca agcgtttggc tcgctacctg accgaggctt tctcccgtaa 2484061 taatggcaag cccgtttctc ttttctctga ttctgtcggc tatctgaagc atgaggcggc 2484121 gggttgccgt cattgtgtaa ttttcaggaa tttgtttttg gatgagctct tgcgtttttg 2484181 taaatggaac aatatgaagt gtcatgcttc ccccaaaacg ggacagacat ttcgccagat 2484241 ccattacctt ttgctttgcg cgctcgcttg tgtatggcgg gctgaagaaa tgaacagctt 2484301 ctaccgacaa tccccgtttc atcgcataaa aaccggccac agggctgtca aaaccgccag 2484361 aaagcatcag catcgctttt cctgctgaac caactggcag cccgcctgca cctttttcat 2484421 cacgaattgt caaaaatgtt gcttcttccc tgatttcgat tctgagcggg atgtctgggt 2484481 tgcgaacatc gaccgtcaat ccttctgtat ttcgcaaaat atggccgccg atttcagcgt 2484541 tcatctggtt tgtatctaat tcaaattgct tatacgctct ctttgtcgcg actttaaacg 2484601 tatcacctgg tttatactga tctttgatag cctttagtgc ggttgcctta atatcatcaa 2484661 ggcggctgtc acacttaatt gccaggctga agctttgaat cccaaacact tgctttaaat 2484721 gaggaaaaag agcctcagga tcctctccat ttaatgtaat cgtcatacga tccctgttgg 2484781 aaaagtattt taaattcgga tagtctttca aaacgagtct gatgttttgt tttaagcgct 2484841 caataaagct ttttctgttt ttgcctttgg tcgaaatttc cccaaaacga attaatatat 2484901 gatcgtaatt catgttctac ctcatcattt cccttaattt tttgatgcca ggacgaagcg 2484961 cgttcataaa cggttctgcc acatcgcttg tctggctgta atttaaactg attctgatgc 2485021 tgcttccggc aatctgctct cctttgccca tctctaagag aaccttgctg ggcttatgtt 2485081 cttttgccga gcaagccgat gttgtggaga cgaatatatc ctgttcctca agcatgtgta 2485141 aaagcacttc cgctttaatc cccggtacag agaaattaat aatgtgcggc gcgctattca 2485201 tttgaggcgt gttgataacg acgccctcaa tttcactcag cctattcata aacaattcct 2485261 ttacggcagt catcgtgtca agccgtgtgt caaaatcagc agaggccaga ttaatggcct 2485321 tggcaagcga aaccgcacca gcagtatgtt ctgttccggc ccgtatgcct ttttgctgag 2485381 agcctcccgt tatgagcgga ataaggcgtg ttccttcttt tacaataagt gcgcctgtcc 2485441 cctttaggcc gtgaaattta tgccccgaaa ttgaacatag atcaatgccg gccttttcaa 2485501 ttgccaaggg cactttatag atgccctgca cataatcgac gtgaaacaaa atgttcgaat 2485561 gctctttcag cacttctcct gccgcttcaa tcggctgcac ggaaccgact tcattgttca 2485621 catgcatcat gctgacaagc acggtatcgg gacggatggc tgcttttaga tcttcaatag 2485681 aaacaaatcc gtcttcattc acagaaagat aagtgatatc aaacccgaac aactctttca 2485741 gctgttctaa cgattccgta acggatggat gttcaataga agtggcaatg atatgtttgc 2485801 ctgtttttat ctttgacaaa gccgctcctt ttaaagccgc attattggct tctgtggcgc 2485861 ctgacgtaaa tacaatatca tattttttta ggcctaagga ccttttgatt tgatttttgg 2485921 ctgcttgaag cagctgttcc gtttcggctc catatcggtg caaagatgaa ggattgccaa 2485981 agtatcggct gctcgtctgt tcatatacgt tcaagacttc atcgtaaggc ttcgtcgttg 2486041 aactattatc taaatatatc atctttttta ctcctttatg aaagcggtac aaggtatgat 2486101 atttatgtta ccataacaaa atttaataga aaattacgaa aaactagtat tgacttctaa 2486161 tttttttacc atataataag atttgttcgt ttcgtcatat tatctgacaa ttaattgaca 2486221 gaatatttta acataattat taggaggatt tttttcatga aacactcact gcctgtcaaa 2486281 gataccatta ttattggttt catgctattt gcgttattct ttggagcagg aaatatgatt 2486341 tatccgccgg aacttggaca agcagccgga cacaacgtct ggaaggccat cggcggattt 2486401 ttactgacag gggtaggcct gccgcttctc ggcattatcg ccatcgcatt aaccggtaag 2486461 gacgctaaag gccttgctga caaagcgcac cctgttttcg gcacaatctt tactgtcgtg 2486521 ctttatttat caatcggacc attattcgcc atcccgagaa caggaactgt ttcatatgaa 2486581 attggcgctg ttccgttttt gactggtgta ccagaaagac tttctttatt aatatttaca 2486641 cttatctttt tcggcgttac gtactattta gcgttaaacc catctaaggt tgtggatcga 2486701 gtcggaaaaa ttctgactcc catcaaattc acaattattt taatcattgt tctcaaagcc 2486761 atcttcacgc cgatgggcgg attgggcgcc gtgacagaag catataaagg aacaccggtt 2486821 tttaaaggat ttttagaagg ctataaaaca atggacgcac ttgcttcaat tgtatttggc 2486881 gttgtcgttg taaatgctgt aaaaagcaaa ggcgttacac agtctaaagc tcttgctgca 2486941 gcctgcatta aagcaggtgt gattgccgct ttaggcctga ctttcattta tgtatccctt 2487001 gcttatttag gtgcaacaag cacaaatgcc attggtcctg ttggtgaagg agctaaaatt 2487061 ttatctgcgt cttcccatta tttattcggt tcattgggca acatcgtact cggagcagcg 2487121 attacagtcg catgtttaac aacaagcatc ggccttgtca catcttgcgg ccaatatttt 2487181 tcaaaactta ttccggcatt atcatataaa attgtcgtta cgattgtcac gttattcagc 2487241 ttgatcattg cgaatttcgg actcgcgcaa attatcgcgt tttctgttcc tattttatca 2487301 gctatctatc cgcttgccat tgtcattatc gttctttcct tcatcgataa gatctttaaa 2487361 gaaagacgcg aagtgtacat cgcatgcttg atcggtacag gacttttcag tattttagac 2487421 ggtatcaaag cagccggttt ttcacttgga tctttagatg tgtttctaaa tgcgaatctt 2487481 cctctttaca gcctcggcat cggctgggtg cttccaggaa tcgtcggagc ggttatcggc 2487541 tatgtgctga ccttattcat cggaccatcc aaacagctta atgaaataag ttaatgtcac 2487601 agaacgcctg cgttattgcg caggcgtttt gtaataaaaa aagagcctgc tcattacact 2487661 gcgggctctt tttcatggtc gtgattatct aagcggatat gtcagctttg attttttcaa 2487721 ctgcacctgg cgcagccttt tctacagcgg cagcggcaat ttcataagag tcgtcataat 2487781 caaaagcata aaaacgtctt tccgcttctt tcagctgttc agataaaata tgattctggc 2487841 ttctgaaccg gtttccgaac tgaatgattt tttcaatgag gatgacctgc tcgacaagtt 2487901 cctctgattc ccggcttgcc ctgttgacga tatcttctgc ttgtttcaaa tgggctccgg 2487961 cttcttccat atttaatgga agttcgttta gttgattgac cgtttcttga atatgatgat 2488021 gcgcgttctc cagcatctct tgaatatggc tcggaatgcc tggaatgttg ctagtcttca 2488081 gcagtcttgc tgtctcagaa attgtttttt tcaaattgct gagcgtctcc ctcgcctgaa 2488141 gctcttcttt tctcagcgct tgcagatttt cacgatactc ggcatgctct tttttcactt 2488201 cttcaatttg cttctctatt gaagcaactt cttctactaa aagtgagtag gcgacatgct 2488261 ctgcatcaag cttatcttta acggatgata gcagctttcc aatttcatca aggcgctttt 2488321 caaaagcctg ctgtttgccg agctcaccgg ctgtcagcct gtagctttcc ttcaccagct 2488381 cagtttccgc tttcgtatgc tctttctctt ctttaagctt gtcgtaagca ataatcaatt 2488441 caggcatttt gcttagtacg gattgaccgg cttcaacttc gccctccagc tgctgataaa 2488501 cagattgaat attttcgtca atgagctgca ggattgcgga cgcttcatca atatccagtt 2488561 cagtcatcag gacatgttcc gctcgtttca gctggtttga cagattttct aattccttat 2488621 caagctggat atgctcaagc ttgtaccctt tttctttcat ttcgccatag ccatccttga 2488681 gctttgcaat ctgtccgggc accgtctgtt tacagtcagc taacagcttc ggcacatcat 2488741 ctatgtatga ctgaagccgt tcaagattgc ggtcctgctc aagcagtact tttcgtgcag 2488801 taatatagtt tccgccttct gtttcttctt caaattgttt gatgccgctc caaatttcgt 2488861 ccagatcctt ttcaaggctg tcataaagct ccccgtaaag gtggctgtaa gccagcaggt 2488921 tttttcgaga tttcgaatag cgctccctca cctgttcaat ctcttcacgg ctcttttcct 2488981 cacttgtgac aagatcgctg atttcccgaa gaatcttttc aatgcttgat tcagccgctg 2489041 tcagcaggtc gtcgatatga acgagcactt gattggcctt tttaaaccgg tatttgtctg 2489101 cattttcctc ggcatcataa aggagctctt caactttcgg catgtgggct gtgacaatct 2489161 catcccattc ttcacgccac ttctcaaaga actcttctgt ctgacccgtc atttttaaat 2489221 gttttatttt agacatttct tccacgatcg accgattcag aatttcaatc ttccacgatt 2489281 ccagccggtc gatttcggcg tagatttttt tcctgaaaaa gtagcctgcc gcaaacagcg 2489341 caagcagtac aattaataat ccaatgacaa actccataat gagccccctt gctgtttacc 2489401 ttaatctgtc agggtgtttt atttattcag aaagatttca ggatatgtat tgagaaaaac 2489461 tgtcgttttc attgttatta tgataccatg taacaaacat tttttgacca gaaatcaaaa 2489521 actttttgtg caaaatcggc aggatttgac tattttttca tggggtgaca tcaatgcaaa 2489581 agcgagacgg acatattcac acaccatttt gccctcacgg ctccaatgac acactcagac 2489641 aatatgcaga agaagcctta aaaaaagggt tcgaatcgat tacttttacc gaacacgccc 2489701 cattgccgcc atcttttacc gatcccacgc cgctgaaaga cagcgcgatg gcgcaagctt 2489761 ctttggaacg ctatattcat gaaatttccg gattaaaaaa agaatatcgc ggacagctta 2489821 gcatacggac agggcttgaa gtcgattata tcgctgaatt tgaagacgaa attacattat 2489881 tcctagacac atacgggcca tatttagatg acagcatctt atccgttcat tttttgcgca 2489941 cagactcttc ctatctatgc cttgattatg acgagcatac cttcaaagag ctgatttcag 2490001 cctgcggaag cattgaagcg gtatatgaac aatattaccg gagtatctat tcttccattg 2490061 tagcatctct cggcgtttat aagccaaaaa gagtcggtca catcacactc gtccaaaaat 2490121 tcatcaagct gtttccatac agcatgtcag agcatattcg cggcctcgtt tctctgtgcc 2490181 tgaatgccat tgaagaaaac ggaatggagc tcgacttcaa tacttccggc ttaagaaaaa 2490241 cttacgctgg cggtatttat atcgaggatt ggatgctgaa tgaagcgaag caaaagaaga 2490301 tcccgcttgt gtttgggtct gatgcccatc aagcgggaga tgtcggatat gcgtatgagg 2490361 cgtttttgga acggtgctag ttggtgagcg ccacgtctcc tgtccggaag acgcttctga 2490421 tccaaatctt gatttcttca aaatacattt tataaaaata cggctcgtgc ggctgcatgt 2490481 agagtacttc tgaaatatat tgaggctgga gatagggcat catcaagaga gattttaatt 2490541 ggagaataaa atgaggcagc ggcagcgtta aatattcacg ctgtttttct ccttcctcaa 2490601 tgatcagctg gaagatatac ttttccttca ttagatatgt cgacataatt tccctgatta 2490661 atgtggagtc aattgtgact tcccggtaga caaaacgagt taattgacga tgattatgct 2490721 gataggataa aatatcgaaa accaattgaa gaagctgttc ctgcgtgctt tgagtagaga 2490781 tattgcttgc cgctgtttca agcgttttgc tgtagccttc gtaaaactct gaaactaagt 2490841 gttccatcaa gcctcctttg cctttaaaat agtaggagat gtgcgcaaca tttacatcag 2490901 ctgactttgc gatttcacgg acagacgtgc cagaaaatcc tttttggtta aaaagcatga 2490961 cagcagattc aataattttg tctttggtgc ttactttcat acggctcact ccttcctctt 2491021 gatactattc aagcagaaag ccgctgttcc tgtaagaact tatcgacaaa tgccggcaga 2491081 aaagccggaa ctttgtttta tattatagaa aaagtgaggg ttttccatgt tccatgtcga 2491141 aaaacaatct ggagataaag aaaaagacta tcagcttctg ctaaaacagc tcgaagccat 2491201 gaccgaagac gaaacagacc aaatagctaa ctatgcaaat gcctcagcac tgctgtatca 2491261 ttcgctgcct gaagtcaact gggcgggttt ctattttgcc aaagaagagg atggacagct 2491321 tgtgttaggt ccgttccaag gcctgccggc atgtgttcgg attcctttcg gcagaggggt 2491381 ttgcggcaca gcgtacgcaa acggaaaagt ggaacgtatt gaggatgtaa acgcgtttcc 2491441 gggacatatc gcctgcgatg cagcgtctca atcagaaatt gtgcttccga ttcgtgtaga 2491501 cggaaaaatt gtcggcgtct tggacatcga cagcccagtg aaaaaccgtt tcgacgaaat 2491561 tgatgaaaaa tacttaactc aatttgccga aacgctagaa aaagcgttag cgcagtaata 2491621 taaaagccca aaactgatat cgttttgggc tttttttatt ttattgagtc atgaatcatc 2491681 aagcggtttt tcccgctccg tttcgcgctg tagagcgctt catctgcctc atgcacaagc 2491741 tctttcagcg acttttttgt ttctgtcgtc cagcaggaga taccgcagga aatggttacc 2491801 tcgggtttcg tattttttct gaccgcgtaa accagtcgct cggtaatccg tttccccact 2491861 gcaaccggca catttggcaa ataaatcgcc agctcctctc ctccccagcg ggcaccgaca 2491921 tcatgctttc ggatgttgct tttaatcact gaagcgactt gaattaaaat ctcgtcccca 2491981 gtctgatggc cgtacgtatc atttacattt ttaaaattat caatatcaac aagaataaaa 2492041 acaccctttt gatggatttt catgctgtat tgaatttttt catctaaata cgctcgtgaa 2492101 tacagttcag tcagctgatc tgttttcacg agatgctcaa ggcggtcgcg aagcattgaa 2492161 ttggttacag ccagtgtcgc gtgatgaatc agcgcctgaa acagcttgta catttcaaat 2492221 gtaaaagcgt acagctcctg tttcaataaa accgcaaagc ctaaaagccg gtcgttttga 2492281 atcatcggag cagccatcag cgagccgtac cccgccttcc caaaaacaga ctggccattc 2492341 ccgatgaaaa cccctttttc accttcatac agcttttctt tcagctcatt ataaaaatct 2492401 gacggcttcg cttctttaaa aaatgctgtg ctgcctggga gcaatgttag gttttcaaaa 2492461 tggtctatat gaaaaaatcc cacttcttct gcctgaaacg attctgccat tctcacagcc 2492521 agatcattca ttgtatcagt caatgtcagc cgctgattca ggcgtcgtga tgtttcatta 2492581 atcaattcca aatttgcgat gcttgctttg gattgttcgt agagctgggc attttcaaac 2492641 gcttttcccg cggcgtttgc taacagcgac atttcatcaa ggcaggcatc agtaagaaag 2492701 ctgtcacccg ttccttcagc cttcaacacc ccgtatgtgc cctgctgtcc tttgatcgga 2492761 atataggcga cagattcatt tttccgcaaa atgtctccgg acaaatacac tttgagcgca 2492821 aaggaatcgg atttttcccc ttccatatac agctcttttg caggaatccc taaacattgg 2492881 tcttgatcgt gcgatataaa taaagaaaac tcaaaaagag aaaatgtgct tgtcaagctt 2492941 tctaaaagct gcttcagcac atctgtctga tcaagcagtg aatggaacag ctctgtcatt 2493001 ttgtatatct ttttttggta gatcgttttg ttatagagtc tttcctgttt catcgactgg 2493061 tttaaaaatg aagcaaccac gtccggaagc ccttcaggaa tctcttcatc ctgcctgcac 2493121 gcaagatgga aacgcctgcc ggagccgtcc tcaatcagat aacatgaagc gtttattttt 2493181 gaagcggaaa aacgcgcttc accatctgcc agttttgtca caaagtctga tggtgacggt 2493241 gtaagcgaaa cacaaagggt tgaaaaatag gtttgaatag ccgaagtcag ccatatgaaa 2493301 gagtcggtga atgtgacttt ttcagatttg gttaataaaa aatcgagcat atgataatga 2493361 aaggcggata attgatcttt agtttgttct accatgtttt tatcacctaa aagtttacca 2493421 ctaatttttg tttattatat cataaacggt gaagcaataa tggaggaatg gttgacttca 2493481 aaacaaataa attatataat gacctttgtg tgaaatattg cagccttttt gttcagcttc 2493541 tatgttttca ttttgttcct tatcaataag gtgtatcgtg taactctctg ctgctggagc 2493601 gaggatacat gaaaacaaaa tgtgcatggt cgaatagagc agacggtttt tattttccac 2493661 aaaaataaaa ccaaaggagg agtcacatta tggctcgcta tacaggtcca tcttggaaac 2493721 tgtcccgccg tctaggaatc tctcttagcg gtacaggaaa agaattagaa aaacgccctt 2493781 acgctccagg tccacacggc ccaggacaac gtaaaaaatt atcagaatac ggtttgcaat 2493841 tgcaagaaaa gcaaaagctt cgtcacatgt acggtgtaaa cgaacgtcaa ttccgcactt 2493901 tgtttgacaa agctggcaaa ctagctggta aacacggtga aaacttcatg attcttttag 2493961 attctcgtct tgataacgtt gtgtacaagc taggtttagc acgtactcgc cgtcaagctc 2494021 gccaattggt taaccacggt cacattcttg tagacggaag ccgcgttgac atcccgtctt 2494081 acctagtgaa acctggtcaa acaatcggtg ttcgcgaaaa atcaagaaac ctttctatca 2494141 tcaaagaatc tgttgaagtg aacaacttcg ttcctgaata ccttactttc gacgctgaaa 2494201 agcttgaagg tactttcact cgtcttcctg agcgttctga acttgctccg gaaattaacg 2494261 aagcgcttat cgttgagttc tactctcgtt aatcgtttta aaaacccctg ccgctatgcg 2494321 gtcggggttt ttttatcggc tttcgcctct tgctggccaa cactatcttg cgcctgctgc 2494381 tcccaatgat cccgctgcag ccgttctttt gcaatcgtac acatgagatt cacgctttag 2494441 cgctcctttc atttaaaagg tggtgattgg tcgtgtttgc cctatctaat atactctttt 2494501 cctttcattc ctatgcggta aacaaaaaga tcctttgcct tcagtggcaa aggatctttt 2494561 tcttatttat acgtcacaag gaagtatttt ttcttcccgc ggcgcagaac agtaaattgg 2494621 ttttcgatgc ggtcttcacc tgatagggta taatttattt ccgtctggcg ttcaccgtta 2494681 atgtaaacag ctccgttttg gatgtcttca cgcgcttggc gtttagaagg agataattta 2494741 gattgcacca acacatctac aagtgaaagc tcttgggtgc tgtcaacttc catagaagga 2494801 acatctttaa agcctacttt tacgtcttga gcagaaagct ctttaatatt gccgctgaac 2494861 agcgcttggg agatgttgat ggcttgctcc agcgcctcgc gtccgtgaac aagtgatgtc 2494921 acttcttctg ccaggcgttt ttgcgcttca cgtttttctg gcgccgtttc tgttttttca 2494981 gcgtatgctt caatttcctc ttttgaaagg aacgtgaagt atttcaagta tttgacaacg 2495041 tcacggtcgt ctgtgttgat ccagaattga tagaattcat atggcgatgt tttttcttta 2495101 tcaagccaga tcgcgccgcc ttccgttttt ccgaacttcg tgccgtctgc ttttgtgaca 2495161 agcggaatcg ttaggccaaa cgcttttgct ccttcttctt ctgattttct gatcagttca 2495221 agacccgctg tgatgttgcc ccactgatcg cttccgccga tttgcagttt acagtttttg 2495281 tctctgtaaa gatttaagaa atcataagat tgaagaatca tgtagctgaa ttccgtgtac 2495341 gagatgccgg attcaattct tgagctgacc gtatcttttg ccagcatgta attgatgccg 2495401 aaatttttac caacgtcacg aaggaaatcg atcacattca ttttgccgat ccagtcaaag 2495461 ttgttcgcga tgacagctgg gttttctgct gcttcaaaat ctagaaatct ggacagctgg 2495521 tttttgattt tttgggacca ttcggatacg atgtcagcag tgtttaatgt acgctctgct 2495581 ttttttccgc ttggatcacc gatgaggccc gtcgcgccgc ccacaagcgc aatcggatga 2495641 tgccctgcaa gctgaaaacg gcgaagtgtt aaaataggca gcaggtgtcc gatatgcaag 2495701 ctgtctgctg tagggtcaaa gcctgagtac aagcggattt tttcttcatt cagctgttta 2495761 tttaaccctt cttcatctgt catttgctga atcaatccgc ggaaggataa gtcttcaagt 2495821 aagttagtca taagataaag ctcctttttt aattaaaata aaaaacgccc cttcgtttac 2495881 acgaagggac gattgattat cgcggtacca ccctactaat aagagaatgc aaacattcgt 2495941 cttatcactt tgcctgataa cggatcaggt ccgttctttc actactgaaa gcctggccgg 2496001 ctttgtttgc aaaagcggtt catgagtgta ttcgatatat ccgtctgtgc tgattttcac 2496061 cggccatcag ctctctggaa cgtaaggata ttctacttgt ctcaatcttt accttttcat 2496121 atgaagctat atcattttta acataaataa aatcctgtgt caacgccgcc ttttaatcct 2496181 ccattgttga cagatctcca gccggcagat taagctccca tgccttcagc acgcgcctca 2496241 tgatctttcc gcttctggtt ttcggaagct tatctttaaa ttcgatctca cgcggagccg 2496301 catgggctgc aagaccctgc tttacaaata ggcggatctc ttctttcagt ttatcagacg 2496361 gctcaaatcc ttccctgagt gcaataaagg ctttaatgat ttctccacgc accgggtcag 2496421 gctttccgat aacgcctgct tctgcaatag ccggatgttc gacaagcttg ctttccactt 2496481 caaatgggcc gacgcgctca ccggaggtca tgatgacgtc atcaactctg ccttggaacc 2496541 aaaagtatcc ctcttcatcc atgtaagcag aatccccaga cacataccag ccgcccggca 2496601 tgaaatacga ttcatacttt tcagggttat tccaaatggt atgcatcatg gaaggccagc 2496661 cctttttgat ggcgagattg cccattcggt acggcggtag ctcgttgcct tgattgtcaa 2496721 cgatcgctgc ctccactcct ggaatcggct tacccattga acccggttta atatccatgc 2496781 aaggatagtt gcagatgagc tgactgcccg tttcggtcat ccaccaggta tcatggattc 2496841 gtttgttaaa aactttatgt ccccatctga tgacttccgg atttagcggc tcaccgacac 2496901 tgagcacatg ccggagtgaa gttagatcat atttcgcagc catttcatct cccgctccca 2496961 tcagcatccg aaaagctgtc ggcgcgctgt accagacatt gacgccaagc tgttcaatcg 2497021 ttccatacca gctttccggg ctgaaacgtc cgccgacgat gacatttgtc gctccgttca 2497081 gccacggtgc aaaaatgccg tataccgtac ctgtcaccca gcctggatca gccgtgcacc 2497141 aataaatgtc ttcttccttt aaatcaagga cccactttcc tgtttgatat tgctgaatca 2497201 tcgcttcatg gacatgcaac acgccctttg gcgtaccagt ggaacctgat gtatagtgaa 2497261 gcagaaagcc gtctttttta tccatccatt cgatatccaa tcttgtgctt tcctgtttcg 2497321 ctgcttcatc ataattgatg atattcgtgc cgctctcagc ctctcccccg actacgaaga 2497381 catgctgcaa gtgaggcagt ttgtctaccg gtattctctc cagcagctca ggcgttgtga 2497441 caacaacctt tgcctcactg ttttcaagcc ggtctttcac cgctccctcc ataaatgctt 2497501 cgaacagcgg cccggcgatg gcgccaattt tgattgcgcc aagcataata aaataaagct 2497561 cgggtgatct cggcataaaa ataaaaacgc ggtccccttt ttccacattt ccataccgtc 2497621 tcagcacatt cccggctctg tttgattctt ccttcatttc tttaaatgtg tatttttcat 2497681 ccctttttgc gtctttataa taaagcgcta ctttgttttt tcgaaacgat tcggcatggc 2497741 ggtcaatcgc ttcatacgcc gcattcagtt tccctgtctc atgccaagag aaatgtttct 2497801 ctgcctcggc ccaatcaaaa tgccggtacg tttcttcata gttttttaag ttatgatccc 2497861 cctctattgc tggtaacgct ttcaagttca tgcccaaaca tccccctttg ctgaagttgt 2497921 cacaattatt atagtatata ttcatattct tctcaatttt taaaatataa accatgttga 2497981 aaacgcttta taatttggta ttcttaaaga aggcatgtat ttttgataag aattgatggg 2498041 acggtgaatt agtggaacat cataaaacat accattcagc aaacatcaaa acagcaaccg 2498101 gctctttact gatagaaggg cctgtctctc cagaggattt ggcaggttat gagtttcata 2498161 aagatttaac cgcatttcgc ccgcctcgcg agcagcatga agcgctagtc gacattgcag 2498221 gccttcccga agggcgcatt attattgcca gagacggccg aaccattgtc ggctatgtca 2498281 cgtatttata tcctgacccg ctcgaaagat ggtctgaagg aaatatggag gatttgattg 2498341 agctcggagc catcgaagta gcgccggact atcggggatg cgctgtcgga aagacgctcc 2498401 tgaccgtcag catgatggat gaacaaatgg aaaactacat tgtgatgacg acagaatatt 2498461 actggcattg ggatttaaaa gggatgaaaa aagatgtgtg ggaatacaga aagatcatgg 2498521 aaaagatgat gaatgcaggc ggattggtct ggtttgcaac ggatgagccg gagatcagct 2498581 cccaccctgc aaactgtctg atggcccgca ttggaaaaaa cgtcagccaa gaatcaattg 2498641 agcaatttga caggctccgt ttttatcatc gttatatgta ttaactgaca ctgacaaagg 2498701 ggaaaaaata atgattgttg agcaaatcat gaaaagagat gtcattacat taacgaagac 2498761 ggatacgctt gaaacagcaa tatgcaaact gaaggaattc catatcaggc atctgcctgt 2498821 tgtagatgaa gaacgacacg tgatcggcat gattacagac agggacatga aacaggccag 2498881 cccgagtatt tttgaagaaa acaaacgaag cctatttctc acacgaagcg tagattcaat 2498941 tatgaaaaag gatgttgtct gcgcccaccc gttagatttt gtcgaagaaa tatcagccgt 2499001 gttctacgag catggcatcg gctgcctacc agtggtacac catcaaaaat taataggcat 2499061 tttaacaaaa accgatttgc tgcggacgtt tgtcaaattg acaggcgctg accagccggg 2499121 ctcgcaaatt gagataaaag taaacgacat caccaaaagc ctcgctgaga tcagcagtct 2499181 ttgccaagac cttcaagtga aaatattaag cgtgcttgtt tatccgcatg acgatcccgg 2499241 tgtaaaagtg cttgtcttcc gtgtaaaaac gatgaatccg ctgccgtttt tgcaggcatt 2499301 acaaagaaat ggacaccacg tcgtatggcc gtcagagcaa agggatctgc tatgagagac 2499361 agtgtattta tctattctcc atcctaccaa acctatatgt ttcatcagga gcatcccttt 2499421 aatcagcagc gggttctgtt aacatatgat ttgcttaaga cgatcaatgc ctttgatgat 2499481 ggagacattg tcacccccag actcgcttca gaagaggagc tttcccttgt ccacacggac 2499541 gattacattc aggccgtaaa gcttgcgggc gccggaaagc tccccgctga agaaggagaa 2499601 agctacgggc tcggcactga agacacaccc gtctttgccg gcatgcacga agcggcatca 2499661 ctcttggtcg gcggcacttt aacggccgca gactgggtca tgtcaggaca agccctgcat 2499721 gcggcaaacc ttggcggagg gcttcatcac ggctttcgcg ggagagcatc aggattctgc 2499781 atatacaacg acagcgctgt ggctattcaa tatatccaga aaaaatatag cgccagagtg 2499841 ctttatattg atacggacgc ccaccacggg gacggtgtgc aatttacatt ttacgataat 2499901 cctgacgtat gcacgctgtc cattcatgaa acaggaaggt atttattccc tggaaccggt 2499961 cagatccaag aaaaaggaag cggaaaagga tatggctatt cctttaatat tccgcttgac 2500021 gcttttacag aggatgattc ttttcttgag gcttaccgga cagcagcttc agaagtcgcc 2500081 gcgtatttcg agcccgatgt cattatcagc caaaacggcg ccgatgccca ttactacgac 2500141 ccgctgacgc atttatcagc aacaatcaat atatacgaag aaatcccccg tcttgcacac 2500201 actttggctc atcaatattg cggagggaaa tggattgcag tcggaggcgg cggatatgat 2500261 atttggcgtg tcgtgccccg cgcctgggcc agaatatggc ttgaaatgaa gggaattgac 2500321 ccgggtcacg agatcccgcc ggaatggatt gttaaatggc aaaaacaatg ccccgtggcc 2500381 cttccgtcga gctggagcga tccggctgat ttatatcctc cgattccccg caagcctgaa 2500441 attacagaaa aaaatgccca aactgtcagc aaagcattat atgcgatacg ttctgaacag 2500501 caaagaacaa agtaaaaaac gacctttacg aagaggtcgt ttttgatttt ttaatcacta 2500561 tttccacacg ccgattttcc ttcatgtgtt catttgtctt gttatccttt actggctttg 2500621 tatccgcata accgacagca ataaagcgct tggagggaag cttctcttta gacgtgaagt 2500681 attgaatcac tccacttgcc cgtgctgctg atagctccca gttcgacggg tatcggtatg 2500741 tcgaaatgtt tcggctgtct gtatgtccct caacctgaat gtcatttgga attgtttgaa 2500801 gaagaacggc aatttggtga agaagtgttt cggcattttt cagcaccttt gcctcacctg 2500861 tatcaaacag cacagcctcc tgaagaacga gcacgacacc gcgttcatcc cgtttggctg 2500921 tcatttgggc cttcaaatga ttgtctttta tatatgtatt tactttcttg agaagctgat 2500981 cctgctgatc ctcttgcttc ttcgtatcag atggggatgt attctttttt tctatggatg 2501041 tttggtccgg ctgaagcccg ttgccttcct tctggatcga gtccactgcc gctttgaatt 2501101 tttgcagatc gatttgggac atcgaaaaga gtaaaataaa gaacacaagg atcaaggtga 2501161 tcagatctgt aaaggttacc atccagctgg atgaagattg actgtttttt ccgcttccat 2501221 tccttctttc aaaacgttct cttctaagct tcatgtacag atcccttttt tgtttttact 2501281 tgttttggct gcttctgcca ttcttcccgt gagctgaaaa cgaccagctg gctttcaagg 2501341 ttgcgcgggt tttttccgga ttgaacaccg ataatccctt ccaccattac ctgcttgatg 2501401 aaaatttcac tttctgtttt ctcttcaagc ttagccgcga tcgggttgaa gaccatattt 2501461 gccagtaatg aaccatataa agtcgtcaga agcgcaatgg ccatgtttgg tccgagcata 2501521 tgcgggtcgt ttaagttttt gagcatcagc acaagcccga cgagtgttcc gatcattccc 2501581 catgccggag cgaattctcc cgctttttca aaaactcgcc gcccttttcg gtgccgttcc 2501641 tccattgctg cgatttctga atccatgacg agccgaatcg tttcttcatc ccagccgtca 2501701 atcgctaaaa gcagcccttt tttcaagaat ggatctttga tttcccgagc ctgatcatcc 2501761 aatgataaaa gcccgtgttt tcgcgcgtga tcggaaaggg aaacaaaggt tttcacaaga 2501821 tctttcacat tgtcttcctg gcggatgaat gcctgcttta acacagaggg cgcttttttc 2501881 agctcacttg gcggaaaact gataaaaaca gcggcgcaaa gtccccctgt tacgatgaag 2501941 aaagaggtca gatcaagaaa agagcggaaa ccgcttactc ccgatcctga aataatcccg 2502001 ataacaataa taatcgttcc taacacaaat ccaacaggtg taagataatc aaaacgtttc 2502061 atcatttctc cccatgaaaa aagcaagaat tcaccataaa ggtgaagctt gctctttgtt 2502121 tttcttatga cttggttgac tttctaagct ctatacggtg cggcagttcg acgatatgct 2502181 cttcaaccgg ctctttattc atgagcttcg tcagcagtct catcgcaacg gcgccgatat 2502241 catatgtcgg ctgaacaact gttgaaagct gaggacgaac catgaggctt aatcttgtat 2502301 tatcaaaacc gataatgtcg agatcctccg gaatggataa gccctgatcc tgagcggcat 2502361 ggataatgcc gagtgccatt tcatcagttg cagaaagaat ggctgtcggt tttttatcca 2502421 ggctcatcag atgctgcagt gcttcgagtc cggaatcata tgtgtaatcc ccttcagcta 2502481 caaattgttc attaaacgga aggttcgctt cttcaagcgc acgtttgtag ccttggagtt 2502541 ttttcgaacg gttgatcggt tctgccattg gtccggaaac gaacgcgatg tctgtatgtc 2502601 ctttatcaac caaaagcttc acggcatcat aaatcgcctg ttcgtaatcg atagcgactg 2502661 acggtgtttc ctcctgctct tctacagaag cggcaagtac aatcggcact ggagaacgct 2502721 taaattccgc cacatgctcg tccgtaatgt ttccgcccat aaacacgatg ccgtccactt 2502781 gtttgccgag cattgtgttt aacaagtgca gctctttctc catgttttgg tcagagttgc 2502841 tcaaaataat attgtattta tacattgtcg cgatatcttc aattccgcgc gcaagctctg 2502901 aatagaaaat gcttgagata tcgggaatga tgacacctac agttgttgtt tttttacttg 2502961 ccagccctct tgccaccgcg tttggacggt aaccgagacg ttcaatggct tccaagactt 2503021 ttttcctcgt tgtcggtttt acattcgggt tgccgttcac gacacgggaa acggttgcca 2503081 tgcttacatt agcttctctc gctacatcgt agatcgtaat attgctcatc ctaaaaccac 2503141 tccttttact ggatacactt atccttatct atagcataaa cactttatgt agagaaatgt 2503201 cataatgtcc gaatttatgt cgtttatgat ttgtaagcgt aagtcagtag tgtacattat 2503261 ttttcattat tcatcaaatt taattacttc tcatgaaatt atacacgttt ttatagatga 2503321 tgaaaacgta tacttggttt ttataactaa ataaacgaga aagcataaaa aaaggccgca 2503381 ggcgcggcct tttggattgt tcaattaagc gttgactttc accattggct tcagttcatt 2503441 cagccatttt tcgaattcag gaatcgccat ttgctgagca gagtcagaaa gtgcgactga 2503501 cggatcaggg tgaacctcag ccattacgcc atcagcaccg atcgctaaag cggctttagc 2503561 tgtcggaagc aagaggtcac ggcggcctgt tgaatgcgta acatcaacaa agactggcaa 2503621 atgcgtttct tgtttcaaaa tcggcacagc tgaaatatcc agcgtgtttc tcgttgctgt 2503681 ttcatatgtt ctgattccgc gctcacaaag gataatttgg tcatttcctt gtgacatgat 2503741 gtattcagca gcattgatga attcagagat cgttgcagca agaccgcgct tcagaagcac 2503801 tggctttttc acggcgccgg ccgctttcag caattcgaag ttttgcatgt tgcgcgctcc 2503861 gatttgaatg acatcaatgt agtccagcgc ttcttcgata tgagccggag ttacgatttc 2503921 actgataacc gccagatcaa attcatccgc tacacgtttt aaaatttgaa ggccttcaac 2503981 accaagccct tggaaatcgt atgggctcgt acgaggctta aaggctccac cgcgcaaaat 2504041 tttaatccct tgttttttcg cagctgcagc gacttcagct acctgctcat agctctctac 2504101 cgcacatggg ccgacaatga atctttgctg gccgtctccg attttttcgc ctttgatatc 2504161 aacaattgta tcttcaggtt ttttcttgcg ggagacaagc agcgctttgc tgtgatcttc 2504221 ttcctgaagc tctaaaccgg ctttgaatat ctctttaaaa atgtgctgga tggttgaatt 2504281 ttcgaacggc ccgtcattgt tttcaatgat attgtttaac attgtgcgtt ctctgacagg 2504341 gtcaaatcgg ttgacaccct gtgcttcctt cgctttaccg atctctttta caacattgcc 2504401 gcgttcgttg attaatttta aaatttgtag gtttaattcg tctgctttct gccttaaaag 2504461 ctctaactct gtgttgctca tttttttcat cctttccctg cacattcatt ttttattttg 2504521 tagttatcat gcatcttact ataagtaatt ccaaatggaa atactgaaat acaaaaaatt 2504581 ttataaaaac tctactttat tacccaaacg cttttaagtg ataaagtaat ctatgaagct 2504641 atcctacatg atgtgagggc aatgttcaag ggttttttac aaaaaaaagc gccagatgat 2504701 atctggacgc ttttttctat gacaaatgct gctcaatagc ggcttctgta atttgtgaat 2504761 gtgaggtatg ccatttcact tcaccgttct ggatgatgaa tatctgaggg ctttcatgct 2504821 tgaccccata tgtttctgca atgaaattgg acagcggccg ggcttcttgt acttgaagat 2504881 agtaagccgg cacatcctca tgctgatttg caaaggcatc aaactcatga aatgctgcct 2504941 ggctgatcgg gcatgtggtg ctgtgtttca agaagacgaa aacgccttcc tgttctgcaa 2505001 tccgtttaaa ttcttcctca gattgaataa gctgtttagc catgactcaa gctcttcctt 2505061 ccctgctcag cgattcaact gctcagcctg tttttgtgca tctttcagtt cgtcttttac 2505121 atcttctttc gtctggagga cttgatcttt tgtttcatca gctgcctgca tcgcttcttc 2505181 cctcatatct tgcattgcag tcgatgaatc cgttttgtca gatttggaac ggtctctcaa 2505241 atcctttacc ttgttcatga tctgtccaga ctgatccgct acaagctgtg tgatgttgga 2505301 agttttgtct tttgcgatgc tgacatattg cgtgcctttt tccttcgcat ctgccgtcat 2505361 tttatcagtt ttgtcccgta aggcaacagc ctggctgccg agatcgtcgc gaagttcttt 2505421 gcctgattta ggcgctagaa aaagagctgt agtggcaccg atgattcccc cgattaaagt 2505481 tccgattaaa aaatctttac tattaattcc atctttgctc atcattattc ctcctcttag 2505541 tatttttttc tcttacaggg ctgatttttt cttttgcttc catttctccc aaatttccat 2505601 tgctgcttga ctccaagtga caacttgatt gatcttatct tgattctctc taactgatgc 2505661 cgatacagac cctgccgctt gtttcatgga tgtattgaac tgctgtacag aagctcccac 2505721 tccttgaaca gcatgaacga ccgtgttcag cttttctgat ttttcctgaa tatcttcagc 2505781 caggcggttg gtcttatgta aaagctcggc tgtttcagtt gtgatgccct tcatttgtcc 2505841 ctccagccct tcaagagtgg atgcgacgtt ttttagtgtc agctgcagtg acttcaatgt 2505901 tttagacaag tagatcacta atacgagaaa tgcaactgcg atgagtgcaa cgctcaaata 2505961 aagaataata atcatctcaa acctccttgc tgcaggatat actgctgttt acccgttttc 2506021 ttcaatcata aacatgtgta ctgggctgta tacatactat tctccgttat gtaagaaaat 2506081 cctttaataa gctttcccat cagataaata aaaagcagtg agatcactgc tttttattat 2506141 gccatgacgt tttcgtaggc tctcatatat ttttggatat ctcctgctcc catgaagatg 2506201 agaacggctt tatcatgagc ttttaaaaca gatgtgtcat cttcttcaat cagcttggca 2506261 ttatgaattt ttccctggag atcaccgatc gtcagctttc cggcattctc acgggctgag 2506321 ccgaaaatat cgcataaata cacacagtcg gcgccgctca ggctttctgc aaattcgtca 2506381 aggaactgct gcgtccgggt aaatgtatga ggctggaata ccgcgacaat ttcccgatca 2506441 ggatacttct gtcttgccgc ctcgattgtc acttttattt ctgtcggatg atgggcatag 2506501 tcatcaatca gcacttgatc cccaagctgc ttctcattga atctgcgttt gacgccccca 2506561 aaggatttga gagcatgctt aatgatgctg gaatcaattt cttcataatg gcataacgca 2506621 atgaccgcca atgagtttaa tacattgtgg tggccgtacg caggaatata aaacgtatca 2506681 tagaacgtat tgcggacaaa gacatcaaaa gttgtccctt ccgtgctttt tacgatgttt 2506741 ctggcttgaa aatcattttc ttcccccgtg ccataataca caaccgggac gttcgcatgg 2506801 attttcggca gatgctcatc gtctccgcag gcaataatgc ctttgttgac ttgaagagcc 2506861 atctcttgga aagcgtcaaa tacatcgtca atgcttgaga agtaatcagg gtgatcaaaa 2506921 tcaatattcg tcataatcgc ataatctggc tgatagctta agaaatggcg gcggtattcg 2506981 cacgcttcaa acacaaagta ttcgctgttt tcatttccct ggcctgttcc gtctccgatt 2507041 aagaaagacg tcggttttgc gttttggatc acgtgagcca gcagacccgt agtcgacgtt 2507101 ttgccgtgtg cgcccgtaac ggcaacactc gtgaattttt tcatgtagtc gcctaaaaac 2507161 ttatgataac gtatcaccgg aattccctca gacatcgctt tttctatttc aggatgcgtg 2507221 tctgggaatg cgtttccggc gatgactgtc atgccgggtt taatattttc cgcgctaaaa 2507281 ggaagaatcg taatatttct tttttcaagc gctgtttgcg taaaaataaa tttttcgata 2507341 tccgatcctt ggacagtata tccattatca tgaagtattt gggcaagcgg actcataccg 2507401 gtccctttta ttccaacaaa atgataaaca gtcataattg tacctccaac aaacgtctat 2507461 ctgttcccca gtatatgacg ctcatttcaa tttgcgaccg cggcggctga aaagcctccc 2507521 ttagcggcgt attttatatg ttttgttatg tttagtatca ggttatttct ttccgattaa 2507581 acccagatat caagatttgt ctatgcacag ctgctgtaaa gcggcatagc tgttaaatgc 2507641 tctaaacact atcataccat gtttggtgtg aaaatgaacc catattattc gtttattaaa 2507701 tcacttgctg tgatcagcac ctctcgaggc ttgcttcctt ttgcctcaga gatcatgcct 2507761 tccgcttcca tcatgtcgat cagccttgcc gcacgattgt aaccgattct gaatcttctt 2507821 tgcaggcttg aagtgctcgc actgttttgc tctacaacaa actcacacgc ttcgtaaaac 2507881 agttcgtcct cttctttcag ggcagatcct tgtcttacga gctcttcttg ttcaaataaa 2507941 taggtcggcg gcatttggct tctgacgtgg gaaacgacgc ggtcgatttc ccggtctgac 2508001 acaaagttac cttgcagacg aaccggtttt cccgagccgt tttccaaaaa gagcatatcc 2508061 ccttttccga gaagcttttc tgcaccggct atatcaataa ttgttcggga atcaacctgg 2508121 cttgagacag aaaaggcgat tctcgttggg atattcgcct taatcagacc tgtaatgaca 2508181 tcgactgacg gacgctgagt tgcgacgaga agatggatac cgcacgctct ggctttttgg 2508241 gcgatccgcg caatgctttc ttccacatcg tttggagcca ccatcatcaa atctgcaagc 2508301 tcatcaataa tgacaactaa atacggcagc ttttcaccca tttggtgttc agcggttaat 2508361 tgattaaagc ggtcaatgtc gcggacacct gaatgggcaa aaagctcata gcggcgctcc 2508421 atttcctcaa cgacccattt caaagcagcc gtagccgctt tagcatcagt aatgaccggg 2508481 ctgacgaggt gaggaatttt attgtaaggg gccagctcta ccattttcgg atcaatcagc 2508541 agcaccttta cctcactcgg gtcagcttta taaagcaggc ttactaatat tgtattgatg 2508601 catacgcttt ttccggagcc tgtagcgccg gcaatcaagc catgcggcat tttcttcaag 2508661 tcgataacaa caggatttcc cgaaatatct aatcccagcg cagctgtgag cggtgacttg 2508721 cttgtcctga aagctgagct gcgaatcatt tggcgcaaat caaccacctt gctcgtgcgg 2508781 ttcggcactt caattccgat cgtgtttttc cccggaatcg gcgcttcaat ccgaatatct 2508841 ttagctgaga gactgagttt aatatcatcg gacaagttgg tgattttatt cacctttaca 2508901 cccggttcag gatgcacttc aaatctcgtg acagacggac cctgggttac atggaccaca 2508961 ttggcgcgga cattgaaatt tttcaaggtc aaatcaagaa gctgacgctg ttcttcgatc 2509021 cacgcagtat catcttgaac ctgcgctggc gggacatcaa gcagtgcaac attcggaaat 2509081 acatagctgc cgcggcgctc ctctgctttt tgctgtttat gcgtatctct tttcagcatc 2509141 atcacattaa aaggaacgga tggccctttt tgagaagatg cgctttgttc agtccttttc 2509201 tcctgtacac caggcctttt tttcggctct tctgaagctt cgcgaggttt gtctgcgcga 2509261 atttcctgcc ggttttcaag agttgcagta gacgatttgg aaccctgctc catgtgttca 2509321 gttttctcaa gctctgtatg gctgtctggc tgaacatcta tcttcgtttc ctgagcctct 2509381 cccagggtgt cataatgatt atttattatg ctttctgatg gctcttctga ttcttttgcc 2509441 acagtttctg cttgagccag agcctctgat gaatactcat gatcagtaaa taaaggctct 2509501 tcctgacgaa tgtccatttg ttcttcttga acgaacgggg actcagcacc ttctgccgcg 2509561 ttttcatgat gattgtatac tgggctgtct gacggctctt ttgctttttc atcctcagat 2509621 actgcctctg tctgagattc aggagctgtt tgctcttcat caagttcagc ggagaaaaca 2509681 ggctcttcaa atttctctgg ctgctgctcc ctttgttctt cctcagccgt tgcaggctct 2509741 tcgcggccta cttcactgtc tgaaagccct tcagccgccg tatctgtgag catctcaggc 2509801 ggtgtttgct cttcggcttg ttcagctggg aagaaaggct cctctttttc cggctgttga 2509861 acgcctgact caaatggcac tttgttacct gacggctcgg ctggccgttt cgccagcgcc 2509921 tcatcatgct ccgtatcctt tctgtttaaa acgccagaag gctgtttttc aaattgggta 2509981 tccgggaaga aaggactttc tattttggaa tgcgcctgtg tgtctgaagc aggatagccg 2510041 cgttcacgtt cgatctcttc tgacagcagt gttaccttct cttttaccga tttatccggt 2510101 tcgttcaatg tttcagaagg ctttttcggc acatcctttt taacagatgg tttttgattg 2510161 aatccataga caggcgaagg gatatttgtc ggtttaaacg gtttcttcgc cggctctgct 2510221 gcttgatatg tatgctgctc ttcttcattt ctgggacgct ctctgtaagg tgcagcactt 2510281 ggacgaggcg cggatttcgg ttcgtccgat ggtgtgcggc gccttctcag gtcatgattt 2510341 ttgtatccgt caggcacgac tggaaaacgg aatttgcctt ttggatattc ataatatatt 2510401 ttaggatctt ccaatctttt taattgtcct tcaggatgat gtacttcttg ttgctgcgga 2510461 atttgagcgg gttttgtctc ccgttcagca tcctcttcgc tttcgcctaa aaacaaatca 2510521 aaaaatttat gaagccaact cataatttat ctctaactcc cttatagttt tctgggacgg 2510581 tttttagtat accactgctg gtcggcccag aaaagattaa gctatcagca gaaacaaagc 2510641 cgctaaacaa gggcttagcg gcttttcaca tgattcgttt tttttggcgg atttatggga 2510701 gtctaaaact gaaatgcgtc tcccgcctca tagtctcctt ctaacacaag gattcctttt 2510761 tcagcagggg catccggcaa atcaagctct ttcgctgagc agatcatccc gcttgacgga 2510821 acgccacgaa gctctgcatc cttaatgaca agtccgctag gcatcacagc accgactttg 2510881 gcaacgacaa ctttttggcc ttggtcaacg ttaggcgcgc cgcagacgat ctgaagcgtt 2510941 tcttctccta cgttgacttt acatacgctt aatttatccg cattcggatg tttttctttt 2511001 gattctacat aacccacaac aaacttcgga gataaatcaa cgactaatgt ttcttcaacg 2511061 ccgtttctgt ttaaaatctc attcacatct tgcacgaatg tttctgagag cgcaacaggg 2511121 ccgttttcat caatggtcaa gtaagaagac gcattgaaaa tgttgaagcc cgttgtttct 2511181 tttgtttcgt tattgaaaat tttgacgacg tcgccgtgtt tttcatagcc taattgttcg 2511241 cgtgtcacat cttgaagaga gatcaggagc gtgtctccca caccttcttt attataaaaa 2511301 gcgttcataa gtaaaaatcc tttctaatcc tttttcggac ggcttttcgc caggataaac 2511361 accggttcca gctttccttc attgtacaaa aatgataggg cggtaatcgg gacggtgccg 2511421 cctgcaaaga agctcatcga catttgtcct agaatatcat accccgattc attccggatg 2511481 tcagcaagaa tcaaaacgtc ctgatgagga acagagatcg ccagctcacc ttctgcatgc 2511541 tgcttatact catttaagat cgcttcgttc aaaatccggc ttgcgtcgta tccgtcgttt 2511601 gccctgaaga aataaaagta attgccggca accgtatcct ctttgacaac cgtcggcagg 2511661 gaacggagat taaatgcggc cgtctctctg atccgctctt ttgtccagtt ttctttctca 2511721 agcatgcgct ggtcaattaa acggtaggtt ttcccgagat ctagcgcgta ataaattctt 2511781 gtctctgcgg tatgatcgtc ataaatgagc gggatatctt cgctggactt gtccgggaag 2511841 gaagtcgagc ggatgaccgg ataaatgcga gtttctttcc cggtcatttc ctgagccttc 2511901 ccttccattg ccgtcatcgc ttcggagaca tagtacacga tctcatcaat ggcttcgtct 2511961 tttttcagtt cccattttgc aataatcggc ggcaaatcga gtgtaatccc ttttttagtc 2512021 gtttgatcct caacacggag ggtgtctttt tctctgtcaa acagaaagga gcgattctcg 2512081 tgctgaaggc gctgcttcag tatatctgac agcttccttg aggtcatttt caaaccgatg 2512141 tcctccttta cgctttagcg agagagtctg ttaaaaactg ttcaatttct tcttttgttt 2512201 tgcggtcttt gctcacaaaa cgatttactt cttttccttc attaaacacc acaaagcttg 2512261 ggattccgta aatttcccac tctgcacatg tatcaatgaa tttgtcacgg tctacgtagt 2512321 agtaggtgaa ttcagggaaa ttcgcttcca gttcaggcag gaaaggctct acaaaacggc 2512381 aatccgggca ccaatcggcc gaaaacataa atacagacca atcatccttt accgcttttt 2512441 ccagctcttg agttgattca atttttttca tttcatatcc ctccagttgt ttatgttctt 2512501 acatgttttt tatcgatact cgtccatttg gatcatacca aactgcttga ggcaaaacca 2512561 cttatatgca acgaatgaat atgtaagatt ggctttccca ttatcattat catattttat 2512621 ttgcattatc aagctcgttt cgtttaacat cgtgtacatg agggtgaaat ttacagatgg 2512681 atatacataa ggagggattt ttattatgga gtttatcgtc tatttagcag gagaaatcca 2512741 cagcaattgg cgcgaggaaa ttaaagaaaa aacaaaatca ctgaagctcc cgattacgtt 2512801 tgttggcccg atggagaatc atgaccgctc agacaatatt ggtgaagaaa ttatgggcgt 2512861 acagccaaat gccgttttaa aggatgacaa agcctctgac atcaacaact tcagaaccgc 2512921 cgtcctgatg aataaagcag actttgtgat cgccctgttt ggcgaaaagt acaaacagtg 2512981 gaacacggca atggatgcat catatgcgat cgcaaaagga aaacccctga ttatcatccg 2513041 gccggaatcg ctccaccatc ctttaaaaga gctttccaat aaagcgaata ttacggttga 2513101 aaccgttaac caagccatta aggccctttc ctatctattt gaaacagaat aagaaaaaag 2513161 cttgtcgatc cgggcttact gctcgttcaa caagctttta tgaaacctac atattttctt 2513221 taatcgcatc cactgtctgc ttatcgcagg ctgttacaag tttgatgagc atttctttag 2513281 cagcagcata atcatcaata tgaatgatag tagcgtttgt atgaatatag cgggaacata 2513341 ttccgataac cgctgacggc acaccgctgt tcgaaatatg aaccttgcct gcgtctgttc 2513401 ccccgccgga tacaaaatat tgatatggaa tatcatgcgt ttcagccata tcaagaacga 2513461 attccctcat tccgcgatgc atgactgtcg ttctgtcaag aatgcgcagc aaaaagcctt 2513521 ttccaagctg gccgaattca tttttgtctc cgctcatatc gtttgccggg ctggcgtcaa 2513581 gggcgaaaaa caagtccggt ttaatcatat gagaagccgt ctgcgcgccc cttagcccta 2513641 cttcttcctg aaccgttgca cccgcataga gtgtattcgg aagctcttta ccgtgtaatt 2513701 ccttcagaag ttcaatgctt aagccgcatc catatctgtt atcccatgct tttgataaaa 2513761 ttttcttttc attcgccatc gtcgtaaacg gacaaacagg cacgatctgc tgtcccggtc 2513821 taatgccgat tttgatggcg tcttccttat catccgctcc aatgtcgatc atcatgtttt 2513881 tgatatccat cggtcggttt cgctgcgcat ctgtcaataa atgcggcggt atgcttgaaa 2513941 tcacacccgg aaccggcccg ttatctgttt gaatttcaac ccgctgcgca agcaaaactt 2514001 ggctccacca gcctccgagc gtctggaatc tgagcagccc gttgtctgta atggatgtca 2514061 ccatgaagcc gacttcgtcc atgtgcccgg ctaccataat tctcggtgcg tcctctgcgc 2514121 ctcgtctgac tccgaaaaca cttcccagtc tgtcctgaac gatgtcatct gcatatttgg 2514181 ctagctcctg cttcataaaa gcacgaacct gatgctcatt gcccggcgcg ccgggaagct 2514241 gcgtcagtgt ttggaaaagc gctttcgttt cttgattcat gttttcccct catttctatg 2514301 tagtcctttt attttattag aaacaatgaa gttttccaag cactctgacc caatctgctc 2514361 gatcagccgc gtattgctta acaggatttg gctgtttctg tataatgaaa agtacgatca 2514421 accaggaggt gctttatttt gaaattgcgt catcttcttt taggagcagg acttggaatt 2514481 tgtacggctg tcgttgtgag acaatatgtg atgaagcctt atatttcttc agaaaaagcg 2514541 cttcgaattg taaaatctgc ttttaagcag cggggcccga ttgacggatc atggatttac 2514601 acccagccgg agccctacaa tattaacgga gaaacggtac aggtatacaa aaccggcatt 2514661 acacgatcag ctttcggaga attagaacag tatgaagtca tggtggatgc gaaaacggga 2514721 gaaattgttg atgtcattga tacaatcgcc tcttaacacc ggacaagcaa aaaatagaag 2514781 ccgctgccta tgcagcggct cttttttatt atatcgcgcg aatcggtttg tataccggat 2514841 accacatcgc atcctgcact gcctgtataa tgtcttcagg ctcttccgta gcgacgcctt 2514901 ccttcattgc ggtttttgca acttcaacag caacggttgc cgaaacagtg cgcaaatctt 2514961 caacttttgg aagcatcggc gccccaggca ccccgacatt gaccatacct gcgattgccc 2515021 gggcacatgc ttcaaacatg ccgtcggtaa ttaattttga ttttgtaaca atcgttccaa 2515081 gaccgagacc agggaagaca agcgcgttgt ttgcctgccc gatatgatac gtaactccgt 2515141 tatattcaac tggcgggaac gggcttcctg tcgtgatcag cgcacggcct tctgtccatt 2515201 cgattaaatc ctccggcttt gcttcagaaa gagttgtcgg atttgacatt ggcaaaatcg 2515261 ccggccgttt cacatgtgac gccatttctt ttacaatttc ttcagtgaaa gcgccggaaa 2515321 ccgtagatgt gccgatcagg atcgtcggtt tcgcctgccg aaccacttca agaagatcaa 2515381 tgcctccgcc gtctccgttc cgctgataat ccttcacttc atcagccgaa cgggcatacg 2515441 gcttttggaa atcaagaagc tgatccatat catctgttaa cagcccgttc ctgtctatgc 2515501 accagaagcg cttgtatgat tcttcttcac tcagtccctc gcgcaccaat gcttcccgca 2515561 gctgttcggc aattccgatt cctgccgttc ccgctccgaa tataacaact ctgtgatctc 2515621 tcagcggaac tttagacgct tttgcacagg ataagactgc ggccaaagaa acagcgccag 2515681 ttccttggat atcatcattg aaggtacaca ctttatcttt atagcgtttc aaaatgcttc 2515741 gcgcgttttt cgccccgaaa tcctcccaat gcagcaatgc attcggaaat gtttctctcg 2515801 ccagcgcaac gtagtcgtca ataaattggt cataacgttc cccgcgcact ctggaatgct 2515861 ggttgccgac ataaagcggg tcgttcaaga ggctctcctg atttgtcccc gcatctaaaa 2515921 caacagccag cactctgctc ggatcaatgc ccgcagccgc tgtataaacc gccagcttgc 2515981 caatagaaat tgcgattcct ccgacgcccc agtcaccgat tcctaaaatt ccttccgcat 2516041 cagttgcaac aattaaatcg atcgtatcgc tttgatcttt atactgttta aaagcttctt 2516101 tcataccgtc cgggtcatcg attgacagat agagccctcg tggttttctg tattcatggc 2516161 tgtatctctg aattgccgtt ccgactgtcg gtgtgtagac aatcgggagc atttccccta 2516221 aatggtcatt taacaggcgg taaaacagcg tttcattccg atcgtgcagc gccgttaaat 2516281 agacattttt gctcaaatcg tcaggctgtg cggaatattg ttcatacgct cttttcgcct 2516341 gatcatcaat tgttaatacc ttgggcggca gaaagccttt taaaccaagt tcttttcttt 2516401 cttcctcagt aaaagcaaca cctttgttca aaaaaggaac agagagcact tcaaggcctc 2516461 ttaatgttgt ttgaatgtct ccttcgtttg ttactctgaa ttgtttcacc ctgcctcttc 2516521 ctttctgagc ataatagtac taggtttgca ttattagccg gaaaacatgc agggtaaaca 2516581 taaaaatatg ctatcgcttc attcgcttaa ctgacttttt gatgcttccg tcctcctccc 2516641 attgaagggc gcgatactcg gcatcatggt aaaaaataaa ccaagcatct ttttctgctg 2516701 cgaacgcctg ccatttctgc ttttgcggga tagaggtcat cggataatca tcgtaagcca 2516761 gcacccatag cggattgcgg tgggcatgtg tcggcatcag atctgccata tgtacggcag 2516821 tttcacccgc atcctcgcat atcaggacac tgtgtccgtc gctatggcct ccggtgtgat 2516881 gcattgtaat accctctgtg atcgttaagg tgtcttcaaa ggttttgact tggccagcta 2516941 cagcctccca attttctttc caatacgtat ttttcgacct gatattcgga tggcgcattt 2517001 cgtcccattc aacagctgat gtataaatca ctgcattcgg aaagacagag acgagccgtt 2517061 caccttcata ttccgttaaa ccgcatgcat gatcaaaatg aaggtgtgtc attgcgatca 2517121 catctatatc ggcaaccgtt aatccgagtg cagctaatga gggtttcaca ttcgactctt 2517181 gtgtcacgcc atagtttcgt ttttgtttat cagtcagctt gccgtaccca attccggcgt 2517241 caatgatgat attgagccca tccttttgaa tcaaaatagg gtctgttctt agttcaatct 2517301 ggtttttttc attgactgga tattttttag accaaagcgg ctttggcaca acgccgaaca 2517361 tggcgcctcc gtccatatgc gtcacgcctc cgtcaagcca ggtcaacgtg atgtttccaa 2517421 ttttcattgt ttccattttc acccccccct atcatcatgg tagcaaacgg cccataaaaa 2517481 aaacagactc ctgtcagagt ctgtctttac gttctccatt caacctcagc ccgatagatc 2517541 ggctggccga gtgcagagaa tttttcttca tattctgtca taatattgcc ttccagattg 2517601 ctgttatgca aatcgagact gacgtatgtc agcaggaggc cgtactcaga gaagctcttc 2517661 aaagagtact caaataaacc tcggttgtcc gttttaaaat gaatcgatcc gcctttgccc 2517721 attacttctt catatttttt gaggaagtgg gaatatgtca ggcggcgttt ttcatgccgt 2517781 ttcttcggcc aaggatcaga aaagttcaag tagacccgtt tcacttcccc cggctcaaac 2517841 acatccgtca gcgtgtccgc atctatattc agaagcttta cattctgcgc ttcgctgtct 2517901 tttacttttt ggacggctgt cacgatgacg cttttaaata actcaatacc aatataattg 2517961 atgtcgggat tttgtttggc cataccagaa ataaattggc cttttcctgt accaacctcg 2518021 atatggatcg gattgtcgtt gccaaacact gtgttccatt tccctttata atcagcagga 2518081 ttgctgatgg caatatctgc gttttcagcc aaaaagtcat cagcccaagg cttgtggcgc 2518141 attctcatat gattgacacc tctatctatt atttcgacta acaacatacc atgaattaaa 2518201 aagacccgca agctcgtttt tccagtgtat ctctcttaag gccgagcgca taaaaaaaga 2518261 gggtcccgtc tgctggaaca ctcctttccc atgtataaaa acgctctgtt ttgaacaatt 2518321 taacccgtat gatactgaag ggatgtgtac cgttatgggt ttacattatg agcatcaagt 2518381 tcatttattg aaggatatat tgactgacca tcaattggac tgctgcggaa cagtcgcaga 2518441 gtacgagcag cttgagcgtg tgattaaatc actgatggca aacaccgagc ttgattcaaa 2518501 tttcaaaaac gtgcttgaag atgtttaccg ctacagccaa tcaggaatat cgtccaaatc 2518561 catcgactca cacatacaag agcatcagaa cagcctgtct caatgggtag agcaaatgga 2518621 ttcgtattcc tgattaatca acaattcgtt tcatgaggat atgcagctct tccattgcat 2518681 catgaaattc cttatcattg ccttttgctt tatgccaggc aatgaaagta attgtttcag 2518741 ataacacata ccaagccatt cgcaaccgaa ggctttctgt cagctctatg ccgtacatgc 2518801 tcagccagct ctcccaagct ggcttttcga cgtagtggta cagcaaaggc ccgaggtcca 2518861 tcgccggatc agcgatcatg gcgccgtccc agtcaattaa atacagctgg ttgtcttcag 2518921 acaatagcca gttattatga ttgacatcac aatggcaaac gactttctca ccgaaatgca 2518981 cttcatgcag gtgttcttcc aaatacttga tcccttcttg aatcagcggc gaagattgct 2519041 gcacagcaaa tacagcctgc ttcagctgag acaaaagagc ccccgggttc agcggttctt 2519101 ttccaagtct cttcagcatg tccagcaagg cttttgatgt gtgtatttta cgaagcaatt 2519161 cagcaacggg ccgtccgctc atgtctttag gcttcagctc tctgccggtc atccagtgct 2519221 gggccgtaat gacgtcccca ttttccatcc gttttgtcca aaccagcttc ggaacaatgc 2519281 cttcggcgga taaaacagct aaaaaaggtg agctattacg ttttaaaaaa agctgctgcc 2519341 cgttatgttt cgcataatat gcatctcctg tagctcctcc ggcggggaag atctcccaat 2519401 cgctacctag taattgtccc aaccagttca tatcaatgtt caacccatca tttcttaaaa 2519461 tattttagaa ttaaggctaa tcgtttctag tctatccagc gaatgccttt ttcgtacgaa 2519521 tcgtataaaa ataaaaaaga cagctattga gagtctcata tgctaatcaa tagccgtcct 2519581 ttaaatttta gcgctatagc acaaacttcg tcaagcaaaa ctcttaagat ctgatgctaa 2519641 atataagata accgttccga tgccgtttac tgcaaccgtt ttcttgattt ctgttgggtc 2519701 ttcctgaaat cctgatggat cacataaaag ccgataaggt atgtcgtttg gcagcctcca 2519761 ctcgacggag tctggactcg cgtgatggat aacaatgata tctttccatt cgtcaacctc 2519821 gtcaagatca taaagcctgt atgcgataag gtgttctttt agcgtcaagc attcaagatg 2519881 gcgctggatg tctgcagcgg acctaagacg gaatgcagga tgcgcttttc tcagcgagat 2519941 cagcctgcgg atatagtgaa catcttcttt gaatgtttca cggcgatccc agtcgagctg 2520001 gttgatgctg tcactggatt gatagctgtt ttccactccc tgcttcgtcc ggaaaaattc 2520061 ctggccgctg tgaataaacg gcaccccttg ggcaagcaaa ataatcgcgg ctgcaagcct 2520121 ttgcctgctt cgctttcggc tgtcattttc ttgaggaagc gcaaagctca ttttatccca 2520181 aaaggtgtga ttgtcgtgtg attcgacata attgatggac tggcttggtt ccggaacaat 2520241 cggtgctaat gccttccatc cggaagaccc ggcaattcca tgcatcacag cttgtgctga 2520301 ttcaccgttg ccgagcgcaa accctgttgc cttaaggtga aaggtgttcc cttttacagc 2520361 gtcacgaaac atatcattaa aaaagccgat gcccggcatt cttggcgcgt tcgccaaagc 2520421 agctttctgt tcatgcggca gcggtgtagc caggtcccac ccttctccaa aaagcaggat 2520481 tccgggcttt gccttagttg ctttctcttt catataaagc acggtgtcaa tatctaaaat 2520541 cccgaggaga tcaaagcgga agccgtcaac attgtattct tcaagccaat agaccacgca 2520601 atccgcaatg aattttcttg ccatccttct ttctgatgca atatcattgc caacgccggt 2520661 gccgtttgat ggcatcccac attcgtcgtg ccggaaaaaa taaccgggca ctgtcttttc 2520721 aaagggggaa ttctccctct tatacacatg gttaaaaaca acatccagaa tgactcgcag 2520781 accgtgctga tgcagggtat tgatcatttg tttcagctct gtttttctcg tttgaggatc 2520841 atgaggattt gaggcatagc ttccctccgg ggcaaagaaa tgaagcgggt tatatcccca 2520901 attgtatgca tcaagcggct tctcttcatc aactccggca aaatcattca ccggcagaag 2520961 ctccacatgt gtcacaccaa gctcttttac atacgctaat cccgaagaac tgccatttgc 2521021 ggtttgtgta tcagtttccg tcagcgctaa gtattttccc ttgtttatca tgccgctgtt 2521081 ttcatggatg gagaagtcgc gaagatgcgt ctcatagatg acggcatcca cagggtgtga 2521141 gaatggttta agaggagcag tccatttcat ttgatccggg cgcaagacga cgcccttctc 2521201 tccatttaca gtcacagcct tggcatactg gtcaactgtt tccatccatt ctgaattgtt 2521261 gcagatgcaa aacaaatact catatccgtg aaggtcacct gtgaccgtga cggcatagac 2521321 gcctttttcc aagcgagtca tttggaatgt gcgcccgctt ttattggggt gtgaaagctt 2521381 gacagcagct gaggttgcag caggcgccca tactttaaat acggtatgat ccgcggtata 2521441 aacggcgccc agctctccgt cataataaaa ttcgtcatca aacgctgccg tccggatgac 2521501 cgcgccaatt tggagatccg ttttgtggcc gctggatgct ctgacgcaat ggatttttcc 2521561 aaatgtcaca ggatggtcgg atacgcagac gtacttgtat tttgcttcaa gggagtattc 2521621 ctccctgaca gccagaggaa aatctgttat ttctgtctca agccgaaacg gcggtgtcat 2521681 gatttccttt tgttcagcag gaatcagaac agtaatgata ttcatgtcat cgacatacgc 2521741 ttcgaagctg cggcggatgc tgaccatcgg aagctctctc ctccaaacac gtttatgttt 2521801 tgattcttag gggtgaagga ctagatgcca gacgaaacgg ggtagtgccc atgatttctc 2521861 cgtcagcatg gaacgggatt ttgtccttcg tgtaaaatgt aatgtccttc gctttaaaca 2521921 tcgtaacgcc atccatcttt gtatgttttc caaatgccat gagacataaa agccaatatt 2521981 ttttcaaaaa cggctggttt tcaacgatta cgatatcaaa tgtcttctcg cgcggatttg 2522041 ctaggggcgc cgccttcatg cctcccccgt aaaacggatg gttggataca acggcaaacc 2522101 agacatcatg aaattcgcgc gtctcgtctt ccgtcgtaca agctaatgta aacggcttaa 2522161 aggttgccga agcgtgcaaa tgagaaagcg gatacacaag aaatcgaagg cggagaaaaa 2522221 gaaaaacccg tctcaacgga aattccatcg cctttttatt gacatatgcg tcaaacccga 2522281 tcccgatatg attcataaaa taaagaatct gtgatttatc ctgaaggaaa ttgacgctcc 2522341 ctaaatgaaa ggttcttgtt aacgggcgct ttaccttctt gatttcctgt atcagatcga 2522401 tttttttaat agagaaccct cgcgaaaaat cattatacgc gcccgccggc acaaagctca 2522461 gctcaatatc gtcaacatct ttcagcccgt tgacaacttc atgcatggtt ccgtctccgc 2522521 caatgacgat caggcgcttc agcttatatt cctgtatcgt tgaaatctgt ctggcgagca 2522581 cctcggcgtg tcccggatgt tcagttaaaa atgaacggtg ctcaaccttt cgtttgatca 2522641 attctttttg aatggacttc caaacacgca ggccgtttcg atgtcctgct gtcggattaa 2522701 taataaaaaa ccaatggctc atctttctca cctgcttatg ttatgagaaa accgctcaaa 2522761 tcgttctctt ttactccagc cactcctgtc tgcgatagga gtcagacatg cagtaagaca 2522821 atagagcctt tgcagccttt acctgatgat gtttgatcgg agcagtgttt ttcttctgcc 2522881 gctcaatcca ttcttccgcg ctccgcttat ccgctatttc taagccgtat ggcggctccg 2522941 ggtaatcgat gtacgacgtt ctgctcagaa gcaattttcg aaccggaatc tcagcctgtt 2523001 tttcctttac gatctttgac acaaccgagt ccgtacgaaa caggctaagc cctggattta 2523061 acactgatgc agtctgagag gctgttttct tgtcccaaaa acgattttta gaccctatgt 2523121 agacactgtc ttcctcagcc tctaaaaaag aaacgcaata aatttccaga ggagaaataa 2523181 tcacaatgct taattcaacc gccgcctgct gaattttcag cacaggctta tacataataa 2523241 aataagaatc aggcagctgc tgggtcagat aacgcaaaat gcggtcctgc ttcacttggt 2523301 ttgagagttg agatatttct gaaagagtag agcttgccca tttgagctga aaatcatata 2523361 aatgcctttt ataaaaagaa gcaagcgcca ccctgctctt cgggagcctt acatgaatat 2523421 cttcttcgtc ctcaaaccat tggtgtctct cttcttgtat atcggctttt atctcttctt 2523481 ttcttctttt caatgaaaat ttttttcgtt tctgcaccgg ttccggttct tcagcactgg 2523541 cttgcctttc ttcatgctgg cgctccgctg cttctactag tgaaagccag cgctcttttt 2523601 tcaaacgtac aaactggttg atataatggt acggatcaag ctcatatctc gatatataat 2523661 catgaatttt gatgatttgt gccatgtttg tttctccact ccgcaatgaa ttaagataat 2523721 tgaaatttga atatttcctc gtattttggt gattggttca agtgtatttg aaagagcgaa 2523781 aatcgttcag ccatcatcga aacctcgccg ctttcaaacg gaacatgagc tggaaatcca 2523841 tcttcgcctg tccattttct tgccagcgtc atatgaggat gatacggtct tttttccact 2523901 tgaaagccgg cctgaagtac agcctgcttc gtatgttccc gcagtctatc aagcgttttg 2523961 tttttctttg gctccagatg taaaacgcgc ggctttctgc ggtcgccgaa tacatctatc 2524021 ttgccaaact taattgaaaa tggatcaatt tctgaagcaa tctctgctag cgaaccttca 2524081 agcttcttta tttgtgtctc atccgccgct ccgagaaaaa ttaacgtgat atgatagtca 2524141 agcgggtgca cccatttttg aaacgtcaat atcggttcgt ttttcgcagc ctggtagatc 2524201 ggatttgcaa ttccctcagg tatgggaacg ccgatgaaat aatgaggccg tatatctggc 2524261 atccgtctga cactcccttc tttgacagct attattttat caataaagag gctgtgcgga 2524321 tagaggaaca gtgtatgaaa acactctcgc acaaacgttt attatgttag gatattatat 2524381 gacacttgtt ttattcagaa aggaatgaca atgttgaaaa tcgttgcaaa cacagctgat 2524441 ctgataggag atacaccgct agtgagattg aatcggcttc agccggaaaa tgcggcacaa 2524501 gtctatttaa agcttgaatt tttcaatccg agcggcagtg tgaaagacag agccgcttat 2524561 caaatgatca tagaagctga acaaaacggt ttactcaagc cgggatcagt tattatagag 2524621 ccgacaagcg gaaataccgg catcgggctc gccatgaatg cggcagcacg cggatataaa 2524681 gcaatcttag ttatgcctga tacgatgacg aaggaacgga tcaacctact taaagcttac 2524741 ggtgcagagg ttgtattaac tcccggagag gaaagaatgc cgggcagcat caaaaaagcg 2524801 aaggagcttg ccgaacaaat tccgaacagc tatattccaa tgcagttcga taacactgct 2524861 aatcctgatg cgcaccgaaa aacaacagcg cctgaaatcg cccgggcaat agaggaaatc 2524921 ggaaaaccgc tcggcgcttt tgtagcctcc tctggaacgg gcggaaccat taccggaaca 2524981 ggtgaggcgc tcaaagagct ttttccggat atcacggttc atgttgttga gccagcgggt 2525041 tcgcctgtat tatccggcgg aaaacctggc gcgcataaac ttgtaggaac gagcccaggc 2525101 tttataccgc cgattttaaa tgaagacgtt tatgatgaaa ttatcaaaat ctctgatgaa 2525161 gacgcgtata cgacgacaag acggcttgct gctgaagaag gaattcttgt cggtccttca 2525221 tcaggcgctg cctgcttcgc ggcaatcgaa acagcgaaac gcctctctcc tgacaaagtt 2525281 gtggtctgca tgacagctga tacaggagaa cggtacttat caactgattt atggtcattt 2525341 atttaaaaaa aggactggct tcagcagaag ccggtccttt tattttgcaa gctcgtaaat 2525401 ggcctgagca tataacgctg tcgatctcag caggtcatca atttcgatat attcatcctt 2525461 ttggtgtgcg ctgtcagggc gtccggggaa cagcgggccg aacgcgacac cggcttttaa 2525521 ggatctcgca taagtccccc cgccgattga gattaaatca gcttttttac ccagctggcc 2525581 ttcataaacc ttttgcaggg ttttgactaa cggatgatct gcggacacgt gatgcggctt 2525641 gctgtctttg aattctccca gctcaaattc agatgcgctt tcgaatgtat cgcggatcac 2525701 tttgctttct gctgtcacag gatagcggat attgatcccg agctcgcctc cttgcccttc 2525761 tttatagcgc agtgttccga catttaatgt cagctctccg ctgatttcat cctcacagtc 2525821 gatgtccagt ttttttcctc ttgtatcacc tgagaactta tctgtcacaa cttgcacaaa 2525881 ccgctttcct gcatcgtcaa gctcagtctg ctggagaaat tcgcacaata aaatgccggc 2525941 attgatccca ttgttcggtt ccatcgcatg gcaggaaaga ccgtacatac gcaaaatgag 2526001 ctgtccgttc tctattgcag cttccccttt ttggtccgtc gtgcggagca tgtctttaaa 2526061 tgaagacaga atctcttcat ttttcggccc ttcaatgaca gcttccgcag cgtcgggcac 2526121 catgtttaag cgaaggcctg attgaaacga gacaagcact gcctttggtt cagcttgatt 2526181 tgggcggtgc ggaataagta aagaagcatc gatgatccct ttttccgcat taatgatcgg 2526241 aaaatcggcg tcaggcgcaa agcccattgt tggcatttct tcatgcttga aataatgctc 2526301 tacgcatctc caatcacttt cttcatctgt tccgataatc attctgactc gcttggacag 2526361 gggcaaattc atgtctttca cgattttcag cgcgtagaat gccgccattg tcgggccttt 2526421 gtcatcaatg gcgccccttg cataaatccg tccgttgcgg atttcagctg aaaatggatc 2526481 actcgtccac ccatctcccg gcggcacgac gtcaacatgg caaagtacgc cgataatgtc 2526541 atcgccctcc ccccattcaa tatgacctgc gaagccgtca agattttttg ttgtaaagcc 2526601 ttctttttct ccaagctcca gcaatgaagt caggctggca tttacccctt ctccaaacgg 2526661 tttaccgggt ccggcggttg tttcgtccat gacactgttg attctcaaaa attcctgtgt 2526721 atcacgaatt aaatcctctt tttttctgat cacttcaact tcccagttca taatgatccc 2526781 ctttccgcaa gaaatgactt gcaaaaacca aataaaacga ataatattaa tggtgttttg 2526841 ttaaaacgtt cgtaattgga ggatactatg tttcatctaa aagagcagca aacatccata 2526901 aagcaagaaa tcatagcagg gctgacgacc tttttcacaa tggtctatat cgtcgtggtc 2526961 aatccggtca ttctggctaa cgccggggtt cctttcgacc aggttttcac cgcaacgatt 2527021 attgcctcca ttgtcggaac gctgtggatg gccctggcag caaattatcc gattgctatt 2527081 gcgcccggca tgggcttgaa cgcttattta gcctttcatg tcgtaagcgc aagcgatggc 2527141 ggcatcacgt acgcaacagc tttcagcgca gtatttacag caggggttct cttcattatt 2527201 ctatcgttaa cgcctttaag aaaacaactt atagaagcga ttccaaacaa tttaaaatac 2527261 gggatcacaa cagggatcgg gctgtttatt gcttttatcg gtttgcgtca agcgggaatt 2527321 gtggcagctg atgagtcaaa cctggtcact ctcggcaatc tgcattcacc tggtgttatc 2527381 ttaacgctgg tcggcctttt gatcagcgtg gtcctgatgg tgctgaatgt aagcggcgct 2527441 ttatttatcg gaatggcagc taccgctttg atcgcctttt tcaccggtca gctccatttt 2527501 tcaaagggat ttatgtcgct tcctcatttg ccggaaggat tgatgatctc aaatccattt 2527561 accgcttttg gcgatgtcat tcatcacggc ctgtacgctg tcgtcttttc ttttctatta 2527621 gtcaccattt ttgatacgac aggcacgatg atcggagttg ccgagcaagc cgggctgatg 2527681 aaaaacaaca agctgccgaa cgtgcgaaaa gcgctgcttg ctgattcaac cgcgacgaca 2527741 gtaggagctg ttttcggcac aagtccgacg actgcattta tcgagtcttc cgccggtgtc 2527801 gcagccgggg gaagaacggg gcttacggct ttgactgtcg cggtgatgtt tgcggcttca 2527861 atgtttttca gtccgcttgt cagcgccttg tcaggtatag ccgccatcac ctcgcctgct 2527921 ttgattatcg tcggcagcct gatgatgggc tcagtttcca atatgaactg gaaagagatg 2527981 gacgaggcat ttcctgcgtt tctcgtcatt ctagccatgc ctttgacctc gagcatttct 2528041 acaggaatcg cgcttggctt tatttcgtac ccaattgtaa aagcggcgcg gggaaaatgg 2528101 agagagattc atccgctcgt catcgttttc gccattctgt ttttcatcca gctgtttatt 2528161 ttataaggat agaccaaaaa acccaaacgt cgccgtttgg gttttttatg taaacaataa 2528221 agagacagcg gccgctaaaa aacaacaggc ggcaaacgca tagtgcagga tgttgataca 2528281 gctttttctg gcccgataat attcatcact ttccttatcg gtgccaatta aaaaaggggc 2528341 atccatgacc ttgtcaaaaa taagcgtcag gatataacgg caaacccctg tgtataccag 2528401 cagcgcaatc accttcagcc aaattgggga aacaaatatg agaacagtga aagctgacag 2528461 tagcatgtac atctgccttg catactcgcc attcctcagc ataactttaa aaaacaactc 2528521 cttatagcct gtgcagatcg ttcgtctttt aaatatcctt tttgaatttc ggtataataa 2528581 tggttttctt ctcatcctgt cttttacttt tggcattccc gcctcctgac tcatcatcat 2528641 cacaagtcct gcaagggcaa gcctgctttt tttctcttca gtcacctcag cttcaaaagc 2528701 cgtgaacgag gctgtctttt tcaaactgcg gataactgag aaaaacaaaa ataaaatgcc 2528761 aaaaagcgca agcaagtgcc gctcagtaaa aacaatcagg atagcagaac cagcaaaaag 2528821 aatagctctg acaagggtat cgccaatcca tctcgaaatg gagcgcggct ttctgatcct 2528881 gtcttgcttt aaggataaaa agaatatatg aaggccaaac aaataacaca atagagcagt 2528941 gctttctgcg aatgtgatga gaacagaatg actgatcaag ggaaggacaa tgaaaaagag 2529001 aagcagccat ttagccagcg tggccagaaa agaatacaaa agcgcatacc gtttgagctg 2529061 atagatgatt tccttctttt gcagcaaaaa cactttgtcc gcttccatta aaaatgtacg 2529121 aatcgaacct gtaaacatga tcagcacaca cacagcatac agccatctcc attccgccac 2529181 ttcagaccac tcataaagaa ggcctcttcc gttcatcaaa tcaatatact gatagatgac 2529241 aaaagcaatc gccggcaaaa cgatatagag agcgactgtc cagtcaatga ccgcatgcaa 2529301 cactttaaac tgatacttat aatagtcaaa cagccttcga aaaaagagcg tacgcccgtt 2529361 catagccgat caccttgaac tgccttataa aaacagtcaa gcaatgactg cccctctaat 2529421 ccggtcttgt cctgaacatc ttttaacgtg ccttggagaa ataatgaacc tttctcaatc 2529481 atataaaacc ggtcacagat tttttccgcg gtatcgagta catgcgtgca cataagaatt 2529541 ccggctccac gttctttttc agccttaagc atgtccacaa agcgtttcgt cgatatcgga 2529601 tcaaggccga taaacggttc atcaatcaca tacatatccg gcttagagag aaaggcctgg 2529661 ataagcatta gtttttgctg catgcccttc gaaaaggtga caggcagctc atgtttgaca 2529721 tgatctagcg aaaacgtctg cagcaggctt tgggcccgat gcgcaaattc actctcttca 2529781 atgccgtgaa gtgtgctgat cagatccaaa tgctcccaca gcgtcagttc ttcgtagaag 2529841 gacggatgct ccggaatata tgcaaatgaa cagtcgttcc aggcaatatg ccctttaaaa 2529901 tcttctgaaa ggccgagtat cgccttgatt gcggtgcttt ttcctgcgcc gttagctccg 2529961 atcagtccaa ccagttcccc ttttctgact tccagaaaaa catcggtgag cacttttttt 2530021 cggcttgtat acccggcctg ttctattgaa gcttcaagca aatttgtcaa aactcactca 2530081 cctccaaaat ttactacgaa atagaataaa aaaagtttct ttaaccataa taatattgag 2530141 ccgaaataca tagtaatcca acaaggatgg ctgcccaacg cgaaattgga aaaaattaat 2530201 aggagttatc cctagattca tcactgcaat atcgtgtata atgagggcga attattttaa 2530261 caattacaga tgtctgcctt tgttgctatt tcgtacgcag ttgatagtcg tgagttgtgg 2530321 ttagtcaagt ccatccgatc ttatgatagg gagtggtttt ttgaaacctt caacaaaccg 2530381 tatgctaact cgaatcaaat cagtttacat gtttattcaa gaaaaaggtc ttgtgacaac 2530441 acaggaactg gttgacgaat tcggcattac acctagaacg attcaaagag acttaaatgt 2530501 gttggcatat aatgatcttg ttcatagtcc aagccgtggc aagtgggaga caacgagaaa 2530561 gaaagtaaag attacctcat aaattgaaaa ttacataggg ccgcctgaga gcggtccgat 2530621 agataacagg gcgaagaaac tactgagcct tgtttttgtg tgcttataaa taaaaccccg 2530681 cattcggtat gcggggtttt tgtcatgctt gcggctcatt tagcaaatga agctcttcct 2530741 ctgtcagctc acggtattct ccgggtgcca gagcgggatc tagggaaacg cgtcccatcg 2530801 aaagccgctt cagataaacc acttcattgc cgactgcctt tgccatttgc ttgacctgat 2530861 ggtattttcc ttctgtaatt gtcagatata taacggtatt gccactgtcg tttgttttga 2530921 tttccgcttt tgccggcttt gttttatagc cgccctctat gtagacaccc gtttccaaat 2530981 cggaaatgtc ttcccgagaa atctgtgatt ttaaatggac ttcatacgtt tttggaacat 2531041 gctttttagg agaaaggagc cgatgtgcga gctggccgtc atttgtgagc agcaaaaagc 2531101 cctctgtatc tttatcaagc ctgccggctg gaaatggctc aaatctcatc tcctccggcg 2531161 tcagcagatc gaccactgtt tgctgccggc tgtcctcagt cgccgacagc acgccctgcg 2531221 gtttattcat cataagataa atgaactctc gataatcaac cggttccccg tatacggtca 2531281 cctcctgcgt atcaggatca acgtgctcct ttacatcttt ggcaggtttg ccgtcgatca 2531341 tcacggctcc agccttcaca acggctttga cttcttttct ggaaccatac ccgctgttgg 2531401 caagcagctt atcaagtctc attcccaatc tctcctttat aaaagaaagc ccgcagcatg 2531461 cgagccctca gtttcatcat atctagttca tcagcctgca tgtctgcctt tcctaaagaa 2531521 acctggcaaa cggcggccta aaattttctg caaaaatcct aatcggtagc cgcaatacag 2531581 gtagacagct ccgccaacag cggccgcgat caccacaaca atcgcagctt gcatctggcc 2531641 atcctgatag gaaataaaga agcctaatac ccactgcacg attttcacgg caatacccat 2531701 aatggctgat aagaccagca tcaaaacagt tcgtttaaca agtatcttat acgaatagcc 2531761 tgcatggcgc ttaatcatga taaacccata taaaagggaa gcgatatatc caagcgccgt 2531821 cgctaaaatc gctccgtcag cctgcatcag cttgatcagc ggaacattca gcacaagctt 2531881 gatcacgaca ccgatcacaa ggctgacaac cgcaaatttt tgcttattga tgccctgcag 2531941 aatagctgcg ttgactgtaa acaaagagaa cagaattgcg acaggcgaat accaaagcaa 2532001 aatgtttgcc cccagttcag gatgaaggct ctctgacccg taaaagaacg tatacgtcgg 2532061 tcctgacaat agagagatcc cgacaacagc cggaataatt aaaaacagga tcgtctgcat 2532121 cgtttgatta atctgctgat ttaacagctt atagtttccg cttgtaaacg attcagtaat 2532181 cgttggaatt aatgtcagtc caaaagcagt tgctagggaa accgggatca tcacgagctt 2532241 ctgaacatac agggttagaa tcgcaagcat gtcctggctg atggcttgat gaccggcttc 2532301 aatcatcgct ttgttaaacg tatttgtatc aatatagtta tacaaaggga tggctagtcc 2532361 gacaaaaacg tacggagcag catagctgaa cagctcgaaa aacattttct tgtagcttag 2532421 gtttgctgtc ggacccgtat tcggcatcat cgccagcagg ctgcccttcc gtttgttcca 2532481 ataaatataa agcacgacca gccctccgaa ggcaccgatc agcgctgcga aggttgcata 2532541 gcccacagcg atgacaaggc cgccgttgaa aaccttcaaa atcaagaatg tcgcactcaa 2532601 tagaaagatg atgcggacaa tctgttcaac gacttgggaa acagctgtcg gacccatcat 2532661 ttggtgccct tgaaagaatc cgcggacaag gctcataatc ggtacgacca aaagcgctaa 2532721 gctgaccatg cggatgacat aaacgacatg atcaattgtc aggccgttat tatccttgcc 2532781 tcccagcgat atttccgcaa acatcggagc cgatagatac agaatgaaaa aggctatcat 2532841 tcctgtgact agcataaccg acatgcccgc cttgagcatt ttcctgcttg tctcataatc 2532901 cccttttgaa ttatatttgg aaacaaattt agaaacagcg gccggaaagc ccatcgtagc 2532961 aatattcaaa aataaagtgt attggttgta tccgtattga aataatgcac cgcctgtcgc 2533021 cccgaccata atgctgaagg gaattaaata gaccatcccc agaatccgcg atatatatgt 2533081 accgagcgtt aatacaaacg tgcctcttaa cagtttgctt gacatgtttc ttcatcacca 2533141 ttttctacga agattcaact tttctatttt accacaactg ggcatttaga cggtaataaa 2533201 tacaaaagca atcctgtgaa cattcatgtc cgcggcaaaa gacgtttaag gagcggcttt 2533261 ctttcgctat aatagtactg cggacgggtg tccgcacacg aaatgaaaag aaagttgatg 2533321 ataaagatga aacaatatga cgtaatcgta atcggcggag gcccttcagg cttgatggct 2533381 gcgattgcag caggagaaca gggcgctggc gtgttgctga tagataaagg aaataaatta 2533441 ggacggaaac tcgcgatttc cgggggcggc cgctgcaatg tgacgaaccg ccttcctgtg 2533501 gaagaaatta tcaagcacat ccccggcaac gggcgttttt tatacagcgc gttttctgaa 2533561 tttaataatg aggacattat caagtttttt gaaaacctcg gcattcaatt gaaggaagag 2533621 gatcacggcc ggatgtttcc tgtgaccgac aaagcccaaa gtgtcgttga cgcgctgtta 2533681 aacaggctaa agcagctccg cgtaacaatc agaacgaacg agaaaattaa atctgtttta 2533741 tatgaagatg gacaggcagc agggattgtg acgaataatg gcgaaatgat ccatagccag 2533801 gcagtcatta ttgctgtcgg cggtaaaagc gtgcctcata ccggaagcac gggagacggc 2533861 tatgaatggg ctgaagccgc gggccatacc ataacagagc tgtttccgac agaggttccc 2533921 gtcacttctg gcgaaccgtt cattaagcaa aaaacacttc agggcttatc actaagagat 2533981 gtagccgtca gtgtgttaaa taaaaaaggc aaaccgatta tcacacataa aatggacatg 2534041 ctgtttaccc atttcggcct ctcaggacct gccattctca gatgcagcca atttgtcgta 2534101 aaagagctga aaaaacagcc tcaagtgccg atcagaatcg acttgtatcc ggatatcaat 2534161 gaagaaacgc ttttccaaaa gatgtataaa gaactgaagg aagcaccgaa aaaaaccatt 2534221 aaaaacgtgc tgaagccttg gatgcaggag cgctatctcc tattcctgct cgaaaaaaac 2534281 ggcatctctc cgaacgtatc gttttctgag ctgccgaagg atcctttcag acaatttgta 2534341 agggactgca agcagtttac tgtcctcgca aatggcacac tgtcgcttga taaggcattt 2534401 gtcacgggag gcggggtatc tgtaaaagaa attgacccga aaaagatggc ttctaaaaaa 2534461 atggaggggc tttatttttg cggtgaaatt ctggatatcc acggctacac aggcggatac 2534521 aatattacct ccgcccttgt cacaggcagg cttgcagggc taaatgccgg gcaatacgcc 2534581 cgttcttaat cattactctt taaatctctt gccgccaaac tcacatttga acattccccg 2534641 cattcatgtt agggtgagac ttgttttgtt tcacctgatt gcggggtaat tttaagagag 2534701 gaatgagctg ccatcgtacg accatactaa gcctgcgagc aagatatagg cgtacacaaa 2534761 aaattagagg gtgagaaatg ttgaaacata tatctagtgt attttggatt gtgattgcaa 2534821 tcacagctgc agctgtatta tggggtgtta tttctcctga cagcctgcaa aatgtgtctc 2534881 aatcggcaca agcatttatt accgattcat ttggttggta ttatctttta gttgtctctt 2534941 tgtttgtcgg gttttgtctc tttttgattt tcagcccgat cggaaaaatc aaactcggaa 2535001 agcctgatga aaaaccggaa ttcgggttat tatcatggtt tgccatgctg ttcagcgcag 2535061 gcatgggaat cggcttagta ttctacggtg cggctgaacc gatcagccat tacgcaatta 2535121 gctctccatc aggtgaaaca gaaacccccc aagccttcag agatgcactc cgctatacgt 2535181 ttttccactg gggtttgcac gcttgggcca tttatgccat tgtggcatta tgcattgcct 2535241 atttccaatt ccgcaaaggc gcacccgggt taatcagcag cacactgtca ccgattctcg 2535301 gggataaagt aaacggaccg atcggaaagg ccattgactg tattgcagtt ttcgccactg 2535361 ttgtcggggt gtcaacaagt cttggtcttg gcgcaaccca aattaacggc ggtttgaatt 2535421 acctgttcgg cattccgaat gcgtttatcg tccaattggt tttaatcatt attgtgacag 2535481 tgctcttttt actttctgcg tggagcggac tcggaaaagg aattaagtat ttaagcaaca 2535541 caaacatggt attggccgga ttgttaatgt tgtttatgct cgttgtcggg cctacagtgc 2535601 tgataatgaa ctcatttaca gattctatcg gacaatacat tcaaaatatc gttcaaatga 2535661 gcttcagact gacaccgaac gatcctgaaa aacgcgaatg gattaacagc tggacgattt 2535721 tctattgggc atggtggatt tcctggtctc catttgtcgg cattttcatc gcccgtgtat 2535781 ccagaggccg gacgatccgc gaatttttaa tcggcgtctt ggtgacacct tgtattttga 2535841 catttctatg gttctccatt ttcggcgtat cagccatgga tctccagcaa aaaggcgcgt 2535901 tcaatgtagc aaagctgtcc actgaaacga tgctgttcgg aacacttgat cactatccgc 2535961 tgacaatggt gacatcgatc cttgcattga ttctgatcgc agtattcttt atcacgtcag 2536021 ctgattcagc tacattcgtg ctgggcatgc agacgtcgta cggttcttta aatccggcga 2536081 attctgtgaa actcagctgg ggtatcattc agtccgccat ggcggctgtg ctcctatatt 2536141 ccggagggct tgccgctttg cagaacacag cgattctggc agcgctgccg ttttctatcg 2536201 ttatcctgct gatgattgcc tctctctatc aatcgctctc aaaagaaaga agagagatca 2536261 aaaaagcgga gaaactcgat aaaccaagaa gtccaagagt gaaaaaagca tattaacaaa 2536321 aaagatcttt ccgcgcctgc ggaaagatct ttttatttgc gatataaaat aagggcggaa 2536381 aaacagtaaa gctgctcgcc gtctgggtcg cacgccgccg aaaccgtata tttgatatct 2536441 atcagctgct cctccgatat cccttttaaa aatgaattga tttccgtttg taagtctttt 2536501 tcatgctctt catcaaatac cgctaccttc agcattttat ccgctctcct ttctctatca 2536561 atctattccg tttggaacag cgttatgata gagaaatgat gattatctcg tttccggata 2536621 aaaagctttc cgtatatggg atttcctctg tggctcgccg ccgtgctgct ccactttcag 2536681 cagcacggca taaacaatgc gcatatggca gtagctgata aggctgacgc tgaaaaaagg 2536741 gacaatgccc ggcaggtacg caagcaagaa aaagagagca acagtcagcg caagcatagt 2536801 aagcgtatat tgcaaatacg ccacactgag caagagcgaa aatttcacat acagacgttt 2536861 tttccagtca aaatggacaa gcagcggaaa cacataaaaa agcatggata cgaacaaaaa 2536921 gccaaatatc ataatggcga agcgcaggat gtgcagaagg aaatgacttg gataaattaa 2536981 ggccaaatca atataaatga tcactccgat gagcgccagt acagcgccga gcagatttga 2537041 acgaaaaaat tcacccttgt attcctgcca aaacgttttg agcaccggaa cgttgtcctg 2537101 cccctggatc cacttccgca tgacagcgaa taaagccgcg gtcgcgggca tgatgccaaa 2537161 cacgccgaga ccgagcaacg taaaaaacag ccacagcaag tttgtatacg caaatctcat 2537221 aatccattcg caaaaacgca gcatccgtcc cagtgagcca tcatgttcca tggcgccccc 2537281 tccttttttg cattatacat tctgcatctg aaaaagctct ttcatgccga tcggcttctt 2537341 ttcggcaacc gagcgccaca ttccctcacc aaccgcgatg gagtaggctc cagcttcagc 2537401 cccggctaaa atatcatagc ggcgcagcgg gtctttccct aaaaaaagat cctcaagcaa 2537461 aagcggatca cctccgccat gccccccttc atttttgacc acttgtatcg tctgctttga 2537521 ttcaaaaagc ggatagtatt cgattgtctg ctcaggaaaa gcaaacggaa ttctggaagg 2537581 ttcgtgaaat tcatttgatt caatacgtcc ttttgtgccg ttgatcgtca gccggtagcc 2537641 ttcatacggg gccgaaaaaa taatcgagta gcttaacagt gcgccgccat catatttgac 2537701 tgccgccacg tacgtatcct cgatgtcaat ttcctcgtca aaaatacacg cgtcaggcct 2537761 gtatgcagta tataagctgg actggtctcc tgcttcaaga tgatcatcct ttatagaagc 2537821 tttagaggaa cggggatgcc accttgaata gtagtggcat ttttctttaa cacggcacgt 2537881 cccgcaaaaa cgcccgtctt cttccggcaa ggggttccac tcactgtccg gcccatagta 2537941 attcaaggcg ccataagcaa atacctcttc cggattttgc ccgagccacc aattgacgag 2538001 atcgaagtga tgtgttgatt tatggacaga aagaccgccg gaaaactgtc tcgacctgtt 2538061 ccagcgttta aaatagctgg cgccatgata cgtatcaata taccaattta aatcaacaga 2538121 agtgaccctg cctatttttc cgtccagaat catttctttt attttccgat gaaacgggct 2538181 gtagcgatag ttaaacgcga cggtgacttt tccttcgctt ttggcctccg cttcaagcac 2538241 ccgattcgca tcctgcactg ttgtcaccat tggtttttca gtaatcacat ctgtattcca 2538301 ctgaaggctt tttacaatat atgcgacatg cgtatcgtcc ctgcctgcca caatgacgat 2538361 atcaggcttt gagacgcgca tcatctcgtc aaaagcatct tcgctaaact caggcacgtg 2538421 ggccagctcg ggaaatttct tcttgcaaac ggcaaaacgt ttcggatcgg catccagcaa 2538481 tcccgtaatc tcataatgag ttgaaaaccg ctccatcagt ggtttgataa acatactgaa 2538541 tgctctgctg ctcaatccgc aaaagacgat gttcttcaat atcctcacct ctatcgggct 2538601 tcagttagtt gagaaatcag ctgcagcgct tcctctgttt tttcagcata cacagggata 2538661 aacgccgcca tatcgcgatt caattgaaaa gaatagccgt tcagctgttt tttccctttt 2538721 tcgatctgaa cggcatagat cgttttttct cctgtttttt tattaacagt tgtataagga 2538781 gatgtttttt caggaggcaa tccgtttaac ggctgaaaat tttccggatc atcgtaagct 2538841 tgaaacatgt cttcaggcac gatgaaaaca tctccctcat gggcggtaat ttcagtcagc 2538901 agtttttcct gaaaagctgg aaagatatcg accttcccgg cattctgctc ggcggccttt 2538961 tttatttttt cctgtacgcc agcctgcata tcagaaaaga gaatgacatg cattccgtcc 2539021 ggcctgcttg agcatgatgc caaaaagagc actgagacga tcacacacaa agccgtacgt 2539081 atcctttttg tcatttcccc gctgacctaa aaagaggctc cagctctgtc atagctaaaa 2539141 taaacgcgcc ggctccgtgc agatcgtttg tgcttctttc gcggctgaca taatagtcat 2539201 agaaaccggc tgacgttccg acacatatgt ctttgacgag aaacgctccg tcttctgatg 2539261 tttcggtttt atgctgaatc aagccttgat acgcttttag cagtgttgtt tcgtaagctc 2539321 tgtctagata gcctttattg attccttttg cgattgcgta catgtacaga caggatcctg 2539381 agctttccag ccagttatca gacctgtctc ccttatcaac gatctggtac cataaccccg 2539441 tctctttgtc ttgatagcga cagatgcttt taatcatgtc ctgcagcgtg tttttccaca 2539501 catgacggtt cggatgcttc ttcggcagct cttcaatcat gtcagcaaga gacatgacgt 2539561 accagccgat ggaacgtgcc caaaattccg gtgaacagcc tgtctcttca ttggcccaag 2539621 gcattttttt cgcttcatcc caggcgtgat aaaaaagtcc ggtttttgca tccttcgtat 2539681 gctttctcat caatgactcc tgaagcacaa cctgatcaaa cagctccgtc tcctgcttca 2539741 gattggcata tttcagtgca aacggccccc ccatgtataa gccgtcaagc cacatttggt 2539801 aaggataacc gtctttgtgc caaaaaccgc cctcagacgt ccggttcagt gttccatata 2539861 agctgcgcag cctttttgcc gctttgacat accgttcatc cttcgtctgc tcgtataatg 2539921 gaaaaagaat gagacctgct tgaatggcgt ccagttcatc tcttctaaat aatagattgc 2539981 cattatcatc gattaagaga tctgcataag ccttcgcata ctcaaaatac cgcttttccc 2540041 cggttgcttc ccacagccgc aatacaccgc ataagaaaac accctgatgg tagtgccagc 2540101 ggtttgcagg tggcagctcc tcgactgtgt acgtgttcat aatggtgttt gccaatgcct 2540161 ccgcgtacgt aagaggcgat tttacagcga ttgattgatc cattgatccc atccctttcc 2540221 taataaattc cttcctcgcc aaatttcttc gccaaacgat tcgctagcat gaccaaaatc 2540281 agcccgaccg ccgctttaaa tacgccgact gctgtactgt agctgaattg gccctgtttc 2540341 agccctgcag tataaacata cgtatcaaaa atttccgcca cttccctgtt agtcgcattt 2540401 aacagcaaat acacatgctc gaagccaagc tccagcgtgt ctccgatttt caaaatcagc 2540461 aaaacgacga taacgctttt aatggcgggc agcgtaatat gccacatttg ccgcagccgt 2540521 cccgctccgt ccattttcgc cgcttcatac agctgggggt caaccgctgt aatggccgcc 2540581 agataaatga tcgtcgacca gcccgcttcc ctccagataa cctgcagaat atacaggggc 2540641 cggaaccatt cttcgttcag cagaaaattg attttttcac cgccaaaaaa cacaatcagt 2540701 tcattaatca agcctccgtc taccgttaaa agcacaaacg aaagcgatac aacaatgacc 2540761 caagacataa aatgcgggat ataaatcagc gtctgaacaa attttttaaa gagagcaatc 2540821 cgcacttcgt tcaatagaag cgccagcagt atcggcaccg ggaaaaatat ggccaggttc 2540881 aaagcaaata acacgagcgt gttttttaac aagagaaaaa atgtaggctc agtaaacagc 2540941 ctgataaaat gcttcagccc cacccactca ctgcccaaaa tgccgaggaa cggctgataa 2541001 tcctgaaacg caatcacaat tccccacatc gggacatact taaaaagcaa aaaataaata 2541061 caccccggca aaatcatcaa gtacaaatat ttttgttgaa tcagcttgat tagtaagcgc 2541121 tttctttttt cttttttaaa aatgactgca tcaacagccg gcgcttgcgc ttctgctgtt 2541181 ttcatttttt cctagcctcc tttcacggat tcttgcattc actgtagcgc agcaggcaaa 2541241 agtccgtcta caatcatatg atcacatcct gttttatccc tttataatca agggttcagc 2541301 cggtccacct gaaaaaaaga caccgatatt agaaaatgat tattgacaat atctatcaat 2541361 ctttggatta attgtattaa ggtgaagtgg atgttatgaa atggggggtt ttatgaaaag 2541421 aagccaatac aagttttact acaaactgat cacgtttttc tgcctgctca gcaccattcc 2541481 ggttattttg gtcggattat tttcgtacga gcactctcag aaaacggcta tttccaacgt 2541541 ttcggaggaa aaattcgaca cactccagca gacccagcaa agcatcgagc atatattgaa 2541601 aaccgtcgat cactctttaa cccactatgt gagttcgccg cctctccttc gcacattgtc 2541661 cgagcctttg cactcagacc aatttcaaat ctataaccaa gtgaaccaag agctcaatta 2541721 tctgcaaagc tttgataccg atctgtccaa catgacgtta gtcagttata cgaaaaaatg 2541781 gtacatgaac aattccggtt tgtaccgttt gaatacagac actcttcatg aagcagcctc 2541841 agcgtacacg aaacaaaaag cgagccgctc ctattggacg cttgaggaaa acaatcattt 2541901 gatttcaacc aaagaaggca cagcagaaaa ctgccgctac aatatcaatt taattaagca 2541961 gcttcctttg aacagcacaa atacaaaggg attggccgcc gcaagcatcc cgagctgttc 2542021 gcttgtcaaa aatatgcccg gctattcaaa cgccaacaac ctgtttatca tcgatgaaaa 2542081 aggcctcatc atccttcata acaatatgtc tgacgttggt gaatctcttc ataacgacgg 2542141 ctttgtccaa aaagtgctgg cgcaaacggc caatagcgga cagtttgaaa cagtgattga 2542201 ccggattcat tataaagtca cctatcaaaa atctgactat aatgcatgga cttatttttc 2542261 tctcgtttcc ctgcctgagt taaaaaaaga agccaaatca atcggctgga tcacttttgc 2542321 agtatgcctc attttgttaa cgctttcatt gctgttctct tggcttggct cccgccattt 2542381 ttacaagccg atcagggtgc tttacgaatc attcgcaaga catggagcca tacaagagaa 2542441 acaacagcct cctcaaaatg aatttgagtt aattgaacag agctttaagc agctgaagga 2542501 cagaaatgac gaccttgaag aaacgatgaa gcagcaggcc actcatctgc agcaatattt 2542561 tatggtcagg cttatgcttg gaaaactgac ggatgaggag gttgataacc gttttgaaag 2542621 cctcggctta aagcaaaatt ggcggcacct tgccctgctt gtgctccaaa ttgacacact 2542681 gaatcatacg ccttatgaga aaaaagatat ggatctgctt ttgtttgccg tcaacagcct 2542741 gattgagcgc aacatcccga cggacaaaca tcttgccccc gccgtagttg acaaacagca 2542801 ggcgacgatt ttgatcaatc aaagcgggac aaaggaagaa ttcatggctg agctgaatga 2542861 gactgcaagg atgattcagg aaaaagcgga agctgagctg cagctgtctg tcagcatcgg 2542921 catcagccag ccgtttgatg tgctgacaaa agcgaaaaca gcctatgcgg aaggctcaga 2542981 agcgttgaaa tatcggctga aagcggaaaa caagtcgatc atcttttacg aagaccttga 2543041 ccagaaaaaa accttcaaaa cccattttcc aaagcagctt cagcatgagc tgttcgatgc 2543101 tgtcaaagca ggagacaagg agaaagcgga taaatgcctg cacgcgattt tacaagccat 2543161 tttcacccag aacaccaacc cgtatcaatt tcaaatcgcc atcgcccgtt ttttgaacca 2543221 tgtgattgag ctgatgcatg tgcttgggat cgaattgttt gagcttgaag aaaacaaaat 2543281 gctgtatgac caaatttttg agctgaaaac gttcgaggat accgaaaact ggctaaagaa 2543341 tgagtttatt gatccgatga cagacaaagt gaacgcccgc gcggatgccc agtacaaaaa 2543401 tatttccgac aacatcattc atatcatcca tcatgagttt gaatccgaat tgacactgga 2543461 cgaaatcgca cgcaggctgc attacaaccc aaattattta agcagtattt tcaaaaaaga 2543521 aatgggaatt tcattcagcg agtatgtctc aagctaccga caccatatgg cgaaaagctg 2543581 gcttgccgaa accgacatgg cggtcaagga cattgccgaa aagctgaaat ataaaaactc 2543641 ccaaaacttc atcagatcat ttaagaagct ggaagggatt acaccgggaa actaccgcca 2543701 gcaaaaaaga agcatgtaaa aaacccaaaa ccgcttgcgc gttttgggtt tttccaatgt 2543761 tattttgctt gtttaaacgc ttcttcgtat tcctgaataa tttgttttcc tccgcttgac 2543821 tcccattttt ccacttcttt atcgaactgg ctttctgtga tgtctccaat catatatttg 2543881 taggtcgcgt catcaatgat tttcttcagt tcgtcacccc gttccgactc cgatgcggaa 2543941 tacaggcttt cagccgggtt tgagacgata atcttttcat tgtcctcggt cagctcctcg 2544001 tacgccgtcc gaagcggatc tccagtgttt tttaagtagg ctttatcaat ggcaattaaa 2544061 gcggacagcg gctgaatatc agtctgccag tcttttacct ggctttcttt gcgtgtaaac 2544121 gttttgtcct cacctttgtt gtaatgaacg ccgtcaatgc cataagtcat caggctatag 2544181 acatcttctt cggcaattcg gtcaaaaaac gccaagatcc gtttaagctc agcttccgtt 2544241 ttcacactcg ttttcgggaa agcaaacacg ccgttatggc ctcctgatgc ccatacccgc 2544301 tctttcccat ctgggccttt tatgcggttg atgatctcga gcttcatcga tttatcagag 2544361 gcatggtcgc gcagattgac cgcatctacc atattgccaa tataaattcc ggcttttcct 2544421 tgagaaaaca gctcttgctg ctgggttttg cttgtgacgg gaaaatcctt attcatatac 2544481 ccgttatcac gcagcttttt catatagttc atcgtgtctt tgtattcctg tgtcatgaaa 2544541 tcaggcgtga atttgccgcc cgattccttc caatctgtcg gcatgccttc atacgagcca 2544601 atcgttttaa acgcgccgta aatcaagtca ttacggtctg ccagcccgaa tgtatcatct 2544661 ttcccatcct tgtccgggtc gtcctccgta aatgctttgg ccacttcata aagctcatcc 2544721 aacgttttcg gggttttcaa atttaaattg tccagccagt ccttccgaat gacgatcccc 2544781 tgtctggaaa gcgggcgctc tctgtatatc ccgtagagct tgccgtcaat tgtcacattt 2544841 ttattaatga gtttgttcat tttgtttaag ttgggataat ccttgatata atcgccgatt 2544901 tcccaaaaca ttcctgaccg aaaggcattc atgactgacg aatttttaat atcctggatg 2544961 gtcacgattt gcggaagatt gccggctgca agcgctgcat tcagcctgtc ttctttcacc 2545021 gcgtctggaa cccaggtgat gtcgagttct gtatttgtca gcttttcaat ttctttaatc 2545081 gccctgtctt tcggcggctg ctggtgatac aaaatcgcca tccaagacag ctttaccttt 2545141 gaatctgggc cagctttgcc ttcagccgaa gactgatcag ttcctttaca gcccgccagc 2545201 actccgccga gtgccagtac aagcacaatc aaaagcaccc tccatttgtt tcccatcgta 2545261 cccctccgtt tcatatttct ttatcctttg acagatccca gcaaagctcc ttttgcaaaa 2545321 tgcttttgta taaacggata gacaagcaga acagggatgg tcgccaccac tatgaccgcc 2545381 attttaatgg tttgctcagg cggcgggctg cccgacccca tttcagacat atccccctgc 2545441 ataccgcttg atacaatgac gatttggcgc agaagcacct gaattggcca ttttgctgaa 2545501 tcatttaagt acaagatcgc tgtcatatac gtgttccaat acgtgaccgc ataaaatagt 2545561 gaaatcgttg cgatcgcagg aagagacagc ggcagcacaa ttttaaagaa tatgcccaga 2545621 tcattgcacc cgtcaatttt cgcggactct tccaggcttg acgggatatt ttgaaagaag 2545681 tttttcagaa tgatcaggtt aaaggcatta atggctgtcg gcaaaataag cgcccagtaa 2545741 gaatcgagca atccaagcga tttgaccaca aggaaagtcg gaatcatgcc gccgctaaac 2545801 agcatcgtaa atacgacgag aaacatgagc ggctgccggc cgattaaatc acggcgggat 2545861 aacccgtaag ccatcagtga cgaaagaaac atgctgaccg cagtgcctat cactgtcaca 2545921 aacacagaaa caagcaaact cttataaata atatctgttg aaaaaatgta gcgataagca 2545981 tctagcgaaa aagtggtcgg tattaaaata aattttttcg acacgacttc ttctactgtg 2546041 gcaaaggatg ctgcgataac atgaatgaac ggaagtacgc atattaaagc gaacatcagc 2546101 aagaaaccat aaatcaacat atcaaacaga cggtttttca gtgaatgtgc gatagctccc 2546161 acctcccttt gtaagcgtta tcatattttt ggaaaccgag ctcagcatgt gacgatatcg 2546221 tgtctaaaat gtagcaaatc tgtgattgcc atgtctataa tcatttgaac agtgtccccg 2546281 gccgggcggg ggctgccgcg aattgagacc gataacaaaa gaaaaagagc ataatcttag 2546341 aaaatgatta tgctccgttc tcctcctcgt tcagaagttc agccgtattg atttgtggcg 2546401 aaaacccaag ttcattcacg gcagattcaa tggaccatgg ccggcccgga ttatcagaga 2546461 cggcgtaata agtgccatac cggatgttgg tctcaatggc ggctttgaaa atcgacagca 2546521 gatcggggtg agaaagcagt gtctttttcg tccgttcttt ttcatgcagc gtatccattt 2546581 catctgtcac gactgttccg attcgaaggt tgattactga tagcttattt tccaaataaa 2546641 acaaatggcc gatctgttca gaggtcagct ttaatacacc gtacaagttt tttgacagcg 2546701 gataatcgct tgttgtgatt tcccgtccta agagcgagcg cccgtctttt tcatatacat 2546761 ctgtgacatg attgctgctg gcgaacacga gcttttgaat gccgagctcc gctgccgcac 2546821 ggcacagata atagcttgcc ctatagaaaa catccgtcat tttttcaaac tcagcgatgt 2546881 ccataatatc gtatttgatt ttcacagcga gtaaattcaa gatggcatcg gtatcttttg 2546941 gaatcttctt caacagctcc tcataatttg ccgcgtcagc ctgaatggaa gaggctttgc 2547001 catcgaaatg atctttatca agcacagtca cttcatagtc tgaaataagc ccttcagcaa 2547061 gcagtctccc aatcacacca tttccgccgg cgatcagcac ttttttcacg atgttcactc 2547121 ccctttttta tagattgccc attttcggcg gggctgacac ttttttggca ctcacattct 2547181 taggcttatt caaaagtcac cggcagctcc tcaagcgccc gaaatccaaa aagcggccga 2547241 taccgccatt caaaatccgc aagattaagg ctgggcattc gctgcagaag agtgttaatc 2547301 gcaatttgcg cttctaatcg tgccagcgag gaccctaagc aaacatgatg gccatgcccg 2547361 aatgaaagat gcggattagg acttctcgta atatcgaaga catcggggtt cgtgaatatg 2547421 ctagggtctc gattagccgc tcctaacaaa agatagactt gttctccttg acggatcgtc 2547481 accccgcaga tgtcaatatc ctctgacgca actctggctg tcatttgcgt ggggctttca 2547541 tagcgtaaac attcctcgac tgcggtacca ataagatctg gattttctct cagtttcaaa 2547601 agctgttctg gatgctgcag cagacaaagg actgaattgc tgatgagatt gaccgttgtc 2547661 tcatgtccgg cgatcgccag caatatgcac gtagatgccg cctcctcttc cgtcagctta 2547721 tccttttctc tccccttcaa gagcatgctg atcatatcct gttgagggtg gcgttttctc 2547781 ttttgaatca gctctttgaa atatgccata gcctgcacag ccataatatt gccctctgtt 2547841 aatgcctttc ttgagcgggt aaaatcaatc gtttgaatga gactcgcagc ccactccttt 2547901 aattgctccc tatcttcctc cggtacacct ataatgttag ctatgacaaa acttgctaaa 2547961 ggaaaagcaa agtccgaaat gacctccatc ttttttttac cttgcacttg atcaagcaaa 2548021 tgatggacag tttcaatgat atacggctga taactctctg tcgttctcgg cgtaaacgct 2548081 ccgctggcaa gcgtccgcaa tcgtctatga tcaggctggt tctgaaacag catcatttga 2548141 ttttgcacat gtgaaaggtc ctgatatttg gttgagctct caggcagcgg ggtgcggact 2548201 ttgaatctcg catctttcaa aatagcagcc gtttcttcat atcctgtgac ataccagccc 2548261 gggtatttta agaaactccc tttatagata ggatgaacag ctcgcaatgt gtcgtaaaaa 2548321 gaatatgggt ttttcaaaaa ctcagaagat gcagttgacg atgcaattgt cacgtgattt 2548381 tctcctttct gttcaaaaat aaaaacaatc gacatcatac cgattgcttt tattgattct 2548441 ttcagctttt cgcacttaaa ctagccttca tttcttcgac tgattcaact tcaaagccta 2548501 aatcactcag cattttatga tcctccgtct cctcttgccc ggcagttgtt aagtagtctc 2548561 cgacaaaaat ggagtttgcg gcgtaaagcc ctaatggctg caatgtgcgg agattgacct 2548621 ctcttcctcc ggaaatgcga atttcttttg atggattgat aaaacggaac agcgccagca 2548681 cttttaaaca atacagcggg tttaattcgt tgacgccttc taacggcgtg ccatcaattg 2548741 catgcaaaaa attcacagga atggaatccg cgtcaagagc cttcaagctt ttggcgatgt 2548801 caatgacatc ctgtttcgtc tccttcatcc cgataatggc gcctgaacac ggagacagcc 2548861 ccgattcttt tgcgatttca accgtattga ctctgtcatc gtatgtatgt gaggttgtga 2548921 tgtttgaatg gtttctctgt gacgtattca aattatgatt atagcggtct actcctgcat 2548981 ctttgagccg cttcgcctgc tctggcttca acagtccaag acatgcacaa atcttcagtc 2549041 catacgtctc tttaatttcc tgaaccgcat ctacgacctg atccacttct ctgttagacg 2549101 gacctctgcc gcttgccacg atacaatatg tgccgatatt cagatcgtgc gcccgcttcg 2549161 cgccttcaag cagcgtttcc ttattcacca tccggtaaga ctcaatcggc gctttcgaaa 2549221 tcgcagactg tgaacaatag ccgcagtttt ccgggcagag cccggatttc gcattcataa 2549281 tcatattgag ctttactttt tttccgtaaa agtgttttct gatgtgaaaa gccccgtgca 2549341 ttaatagcaa aatatcttca tcaggacaat gtaatattga aagcgcctct tcgtcagtca 2549401 cttctgctcc agccagcacc cggtctgcga gttccatcca ttgattcatt ctcatacccc 2549461 cacttgattc atcagtaatg atagattgat atggtctttt accatatgta gaaccgtttc 2549521 tttcgtcacg ttggcaagct ttggcgtaac ccctaaaatc ggcacaccgc ataagcgctc 2549581 aatcatctca ggattggttt tttcatcttc atcaggagag tcactgattc cattgatgat 2549641 aattccggcg attggaagcc ccatgctttc tgcatatttg acagttaaaa aggtatgatt 2549701 aatggttcca aggcgaggac gcgccacaat aatcatggga agctgcaacg cttttatgac 2549761 atgactgacc aaatagtcct ctcccaatgg cacagaaata ccgcctgcac cttctacgat 2549821 gaagcattca tgtttttctc taatccgccc ccaatggctt aaaacctctt ccatggtgac 2549881 agtctttccc tcaagtttcc ctgcaacgta tggtgcaagc ggcgccttga aggcaaaagg 2549941 cgtaatgtct tcatgagaaa gactggtctg cgacatatct ttcagcaaac ttgtatcact 2550001 atctggatga tggcgcgata tcccgcttaa aaatggttta tacaccccga catgtctatt 2550061 attgtctttc aataaggcag caagaccgct ggatataacc gttttcccta cttctgtatc 2550121 agttcccgtc acaaaaaaac ccctcaaatg atgtgcagct cctttccgat tgaatgaaat 2550181 gtttgcagca aatgatcaat atcacccata ctgtggtcag acgtgattgt aattcgaatc 2550241 cggctttcac ccggcgcaac ggttggcggc cgaatggcag gagcataaat tcccttgccc 2550301 tgcagttttt cagcaaatag gaccgtttta tgggcatcgc caatgactac aggaataatc 2550361 ggtgtgtgat ctcctttcac cacataaccc atattcttca gactggttct gatcatgctg 2550421 atataagaaa ataaaagctg tcgtttttcc ctgctggctt caatgatgtt gaaagcctcg 2550481 tgagcagccg cacagctggc tggcggaata gcggtttgaa agataaatgt tctggcatgg 2550541 ttcagcaaaa agtcgatgaa gaccgctgat cctgccgcaa aacctccttc cgcgccaaca 2550601 gctttgctta aggtgccgat aacaatgtcg ggacaaacac caaagtattc actcgttcct 2550661 tgtcccgaat cgcccaaaac tcctgttgcg tgggcatcat caacgaccac gaaggcatga 2550721 tagcgtttcg caagtgagat gatctgatca agaggggcga ttgtgccatc catgctgaat 2550781 actccgtctg ttacgataaa acggcgctga taacgctgtg tttcattcag cttgttttca 2550841 agatcattca tatcaatatg ccgataaaca actgtatcag ccttagaaag tcggcagccg 2550901 tcgatcatac ttgcatgatt gagctggtca cttaaaatga catcttcctt ttctggcaag 2550961 gatgaaagga caccgacatt ggccaagtaa ccgctcgaaa acagcagggc cgcttctgtc 2551021 agtttaaagc tggcaatctt cttttctagc ttttcatgcc agaccgaatt gcctgtcgtt 2551081 aaacgtgaac cgctgcttcc tgtcccaaat tgctgcaatg ctgtttgggc tgcatcgatc 2551141 aaacgtctat cgcttgcgag ccctaaataa ttgtttgagg accagaccgt ttgattttcg 2551201 ccatcaatat tcctctctgg aaccggcgct ccatccattg accgcaggtt acgatgtacg 2551261 ccggcttctt tcattctgtc taaccgctcg tttaaccagg aatcaatctt caaggctcgt 2551321 aacctcgtgg atcgcttgtt tcataatggc aaccatttcc gagagctctt cagctgtgct 2551381 ggcaagagga ggaagaaatg caatcacgtc cccaagcggt cttgtcagca ttcctaactc 2551441 tctcattttt aaggaaactt tgtatccaat ccgccgatca gccgggtaag gttctttagt 2551501 ttcctttgat cgtacaagct ctgcaccgca cataaagcca agctgccgaa tatccccaac 2551561 atgaggaaga gcgtgcagat cttgaagaag aaaatggagc tttttacttt tttccgctac 2551621 ttgttccaca atgttttcag attcaaataa tgccagattt tcaagcgcaa ccgcacagcc 2551681 aagctgattg cctgtatagg aatggccatg gaaaaaggtt tttaggtttt cataatcatc 2551741 atagaatgcc ttatagatgt cttcagtggc aaacgtaacg gcaattggca aatagcctcc 2551801 tgtaatgcct ttaccggcag ccatcagatc aggctggaca ttctcgtgct cgcacgcaaa 2551861 catttttcct gtacggccaa agcctgtagc gacttcatca acgatcatta agacatcgta 2551921 tgttgtacat agctcgcgca cgcctgccaa atatccttcc ggcatcacga tcataccgga 2551981 cgcgccttgt accattgatt caatggaaag cgcggcaatt tcctcatgat gttcctcaag 2552041 cagctgtgca agctctcgga ggcactgatc acggcactca tcaggatcac cgctttcaga 2552101 acgatacaca taaggaatcg gggccttgta actctcgaac atcaacgggc cgtatacgtg 2552161 gtgaaaaagc tcaattgaac cgacactgac ggcgccaatc gtatcaccgt gatacccgtt 2552221 tttcattgcg atgaattttt gtttctcggg cttcccgatg ttcttccaat actgaaacgc 2552281 catttttagg gctatttcca tcgcctctgc gccgctgtct gaataaaaga cccgcgtgag 2552341 cttttttggg ctgatgtcga ttaatgtttc ggcaagctgg gttgctggaa cattggtcat 2552401 gcccaataac gtggagtgcg caatttttcc gagctgtttt tttatggcgt catctagttc 2552461 ttttttgcgg tgtccgtgga cattaagcca aaccgatgaa aaaccgtcat agtattcctt 2552521 gccgtttatg tctttgactt tgattccagt cccgctttcg atgattaagg ggttttcatc 2552581 ataatctttc atttgggtaa atggcagcca gaggtgcttt ttactttttt ctatcaaatc 2552641 atgagtcatg atcttcctcc cactctatta aaataggctg cttctccagg tcatgtatgt 2552701 acgtgtttac atcattggat ccatcaataa aaaagactcg gcagccctct tcagtcccgt 2552761 attctttcat tgctgtaata cgctgatagc ccattttctt acccgcaaca tagcctgtta 2552821 tgtaatccgg atcgtccgac cagcataatt ctgcaacgac tgccgggtgc cggcttacct 2552881 ttgaagcgag cgcaagggcc tcttttattc ttgaatgagc tggcacgtga ctgtgaagcg 2552941 cccatttttc aaaattagcg tccggccaat ccattctgga gacccgcacc cctttttctt 2553001 ttgtttgatc cattcgcttg cctgtatgaa tatcaaacaa caccgcaccc ctgacatctg 2553061 accattcagg gatttgttca tatgcttttt caatcacgtc tcgtgaaacg ccttcttttt 2553121 ccaataacaa tcgggcaagc ttttgtcctt cttccgggca gctcacttca ttcgtatgca 2553181 caggcaatgg ctgaatggtt tttatcgatt catgtacctc ttcaaattga atttgcataa 2553241 aatcaggttt tcctcttgaa tgggataacc ctttttctaa taaagcattg actgtatgct 2553301 tcatctcatg gaaaggaata agccgttctc cgccggatat atgctttccg ccgtcttcat 2553361 gagatccatt cattgaagcc ctcattctga cactataaaa agtttcttct tgcatcattt 2553421 ctcgcccttt cactgataac tgaagaacgt gtagcgcttc tcacctaaat tgttaaccaa 2553481 ttatattcaa aggttaacaa ttagaatata ttattctctc ctgtttctgt caatagaaga 2553541 aaggatcgat ttatggcagt tggttaaaag gaaacaaaaa gaccgttttc acacaaaacg 2553601 gtctttttcg atttcttttt acagtcacag ccacttttgc aaaaaccgga cagcttcatg 2553661 ccttataact gctgtttcga aatgtcccga agcagaacgg accactcggt agcaatcagc 2553721 agctccctgt ccagcataga cagctgtcaa ttctttttcg attttgtcca cgccctcagc 2553781 cggcgttaac cgatcgtgta caccaacaag actaaggtgc gggcgcggcg cgatcaggct 2553841 ttggatctcc gatgcggaaa aatgctttgc aagcgatggg acgtaataat aaaagccgtg 2553901 cctgtcaaga ttctgtgttt tgatcagcac gtgatgatcc acctggctgc acaaatccac 2553961 acacacctta atccggtcat cgagcgccgc tgtccaccac gccatcaaac ctcccataga 2554021 catgccgatg gttccgatcc tgtcaggctg aacatcagag cgtgactgca tatagtctaa 2554081 cgcacttaaa ctgtcataaa tcatcatccc ccacatcact tttccggtga gaagcatttc 2554141 tttaaatatc tcgctttccg cttttccccg ccgatctcca aacccccaat gatcaatcgc 2554201 aagaacgccg tatccgagtg aagtaagctc atcagaaaaa gaaggcgttt tcaaataatc 2554261 cgctccctca atcagctcac tttttcccct atcatactgg cctccatgcg aatgctgaaa 2554321 caatacggct gggcacggtc cttctgtttt cttcggcttc acaaaataag cgggcgcctt 2554381 ttcatgtcca tttaaatcga gcaggagcgt ttcaacgata ttttcttctc tttcttcaat 2554441 acgtaatgtc tcaacactga ttggcctccg atcaggcaaa tcaccaagca atcgaaacag 2554501 ttgctttctt ctttcggctc tcatcccatc acccttcctt attcgcttac ttcacattta 2554561 cgagacagat ctgggttccc ctttattttt ccaacataaa tcacatcatt tactaaatat 2554621 ttagtaaata ttatggaata tttcgaaaac aattattgta accgcttact tttatatgat 2554681 aatatcaatt tatcaaaaac agatgagtta atattttact aaatagatga gagggatacc 2554741 catggttcgt attaaagata tcgccttgaa agctaaagtt tccagcgcaa ctgtgtccag 2554801 aattttaaat gaagatgagt cgctttctgt tgcgggcgaa acgagacaaa gagtcatcaa 2554861 catcgctgaa gagcttggtt atcaaaccgt tgccaaacgc cgaaaatccc gcgggcaaaa 2554921 acagcgggct cagccgctga tcggtgtgct gagctgtctg tcccctgatc aggaaaggca 2554981 ggacccttat ttttcttcca ttcggaaagg gattgaaaag gaatgctttg aacaggaaat 2555041 tttcattaca aattcgattc atctcggctc ctttcaggaa catatctttc gggaattgga 2555101 tggtgtcatt gtcatcggcc gtgttcatga tgaagcggtt aagcatatca gcgggaggct 2555161 ggagcatgcc gtatttatca atcattcacc agatccgcaa gcatacgatt cgattggcat 2555221 cgattttgaa tcggcttcac gccaggcgat tgatcacctt ttcgacttag gctacaaacg 2555281 gttaggctac attggcggac aagaaaaaga gcatacgctg aaggacggcc aaagcattcg 2555341 cagaacgatt gaagataaac gcctgaccgc ttttttggag tcagccgccc cccagcctga 2555401 gcatgtgctg atcggagaat acagcatgcg tgagggctat cgcctgatga agaaagcaat 2555461 cgatcaaggc catctgccgg aagcattctt tattgccagc gattctatgg cgatcggcgc 2555521 attaaaagcg ctgcaggaag ccggactgca agtgccgcgg gataccgcaa tcgtcagctt 2555581 taacggcatt gaggaagctg aatttgccag cacgccttta acgacggtga aggtatacac 2555641 agaggaaatg ggccggacag gcgtaaaact gctgcttgac cgtctcaatg gccgaacgct 2555701 tcctcaacat gtcaccctgc ctacaacatt aatcgtaaga caaagctgcg gatgtacagc 2555761 aaaggaggtg acataagcaa agattcatca cgatgataag gaggaaaaga tgaaacacac 2555821 ttttgtttta tttctctctc ttattctgct tgttctgccc gggtgttcag cagagaaaag 2555881 ctcagcagat accgcaaaaa agacgttaac catttattct acaatgtcaa ccgacagtga 2555941 aagagatacg ttcagaaaac tagcggcagc attcgaaaag gaacacagtg acattcatgt 2556001 cagccttcat ttcccaggca atgactatga aaatatgatg cgtgtcagaa tggcggccaa 2556061 tgatttgcca gatctattcg atacacatgg ctgggggaaa atcaggtacg gagaatatac 2556121 agcggatctc cgggatatga aatggactca agatcttgat cccaatttaa acagcatcct 2556181 caaaaataaa agcggaaagg tgtatgccta tccaatcaat caggcaaaag acggtctggc 2556241 gtataatcgc aatattttag accgttacgg cattgctccg ccggaaacca tggatgactt 2556301 tatcaaagca ctgagaacga ttaaagaaaa gagcaaggga agcattgttc ccttctggtt 2556361 tgccggatat gacaaaagct cattcgccca atattacgac caattcgcta cacctcttct 2556421 catcacagac cctgcccata atgaaaaaaa acagctcatc aacggcactt ttcaatggag 2556481 taaattcact tatttatcag aaatcctcaa acaaatgcag aaagaaaaat tgatcaatat 2556541 cgacgccgtc acggcaaaaa aatcacagct cattgaatta atggcccaaa acaaaatcgc 2556601 ctttacaatg caaggcggca cactcggcca agacgttgcc cagatcaacc cgaacgtcaa 2556661 ggtcggcatt atcccgacac ctgccatcca tcccggtgat gacccgatat ggatcggcgg 2556721 tgaacgctac acccttgcag catggaaaga ttcgcctcaa ttaaaagagg caaaagattt 2556781 tatcgcattt atggcccgcc cggccaatgc caaacaaatg gctgaagcca catcgcttcc 2556841 ttcagggctg accaatgtga aagctgatat tttctacgca aacgattatg agtattatca 2556901 agatgtcaaa gtcgagcctt acttcgaccg gttatacttg ccaaacggaa tgtgggatgt 2556961 cctgggcacg gttgggcagg agctcgcggc tgacattttg gcgcctcaag acatttcgca 2557021 gaagctggga agagaatata aacgactccg ggagcaatcc gaaacacagg gagctgaaaa 2557081 caatgagtga gatcgcaagg gacgttcatg tgaaacaggt taagccaaaa aagcagtcct 2557141 cactttggtg gatgtacatt cctgctttgc tctccgttct ggtctttatg atttacccgt 2557201 ttgtgaaagg cacattgatt acctttacaa actggaacgg attttcacaa gtctaccaat 2557261 gggttggatt cgcgcaatat gaaaggctgt tttctgatcc tgatacttgg catatcttaa 2557321 aaaacacgct gcattacggg cttggcagca ccttttttca aaatgtggtc gggcttctgt 2557381 acgctctcct cttaaatcaa agcattaaaa cgaaagcggt aacaagaaca attgtgtatt 2557441 tgccggtgat gatcagcccg ctcattatgg gctacatttg gtactttttc ttctcctatg 2557501 acggaggcgc gctcaacgat ttgctcgggg tcttcggcat cagccctatt aatgcgctcg 2557561 ccagtccctc gctcaatcca tggatcattg tcatgattaa cacctatcaa tatgtcggga 2557621 tcgctatggt tgtctactta gccggtctgc aaagcattcc gaaagactac tatgaagcgg 2557681 cgcaaatgga tggcgcgaaa caaggccagc agttttttac catcacgctg ccgctgttaa 2557741 tgccctccat taccattaat atagtcatca acattatcgg aggcttaaag ctgtttgacg 2557801 tcatcattgc actcaccgca ggcggccccg gaaatgcgtc acaatccatg tccacgttta 2557861 tgtatgattt gtatttcaaa cggcaggatg ccggctatgc cgcaacgcaa ggcatattta 2557921 tggcatttgt cattttgatc atcagctttt gcgcgcttgc gtactttaaa agaaaggaga 2557981 cggaaatgtc atgagagccg cccgtacaaa aagcatgcgg atcattacgc ttcttgcagc 2558041 cattgtggcc tgtgcgcatt ttattccttt ttatatcctg ctgaccactt cattgaaagc 2558101 aaaaggagac tacagttcga aatggatatt tccagccgac atctcctttc ataatttttc 2558161 agaggcgtgg gagcgcgctt cgctaggaaa ctcttttata aacaccatga tcatcacagg 2558221 tttttctgcc ttgttattaa ttatattcgg ctcacttgcc gcctacccgc ttgcccggcg 2558281 ggaaacgaaa ctgaataaag ccgtttttgc cttgctgatt tccattatga tcatccctcc 2558341 gttaacgtcc atggttcctt tgtaccgaat ggtcgtggac gccggaatgg tcaatacaca 2558401 cgcaatcgcc attttcatca atacagcggc ttacatgccg ttaaccgtat tcttatattc 2558461 aggctttatc cgatcgacca ttccaaaaga gcttgtagaa gccgcaagaa ttgacggtgc 2558521 aggcatgctg aaaatctttt ttacgattgt gtttcctctg ctgaagccga tcactgcgac 2558581 catctgtatc atttcttgtg tctttatttg gaacgactat caatttgcca ttttcttttt 2558641 acaagatcaa aaggttcaga cattaacagt agccatggca ggttttttcg gagaaaacgc 2558701 aaacaacctt catttagttg ccgcagcggc acttatggca atgctgccga tggttgttct 2558761 gtttttggcg ctgcaaaaat actttattgc cggcctgtct tccggagcgg taaagggtta 2558821 acattaaagg gggaagcaat atgaaaaaga ttacatttat cggtgcaggg agcacgattt 2558881 tcgccaaaaa tgttttggga gactgcctgt taacagaggc actgaatgga tttgagttcg 2558941 ctctttacga cattgatccc aaacgcctgc aggaatccca gctcatgctc gaaaatctaa 2559001 gagaccgtta taacccaagt gtggccatca acagctatga tgacagaaaa ctcgccttgc 2559061 aaaacgcagg ctatgtcatc aatgcgattc aggttggagg atacaaaccg agcacagtca 2559121 tcgatttcga gattcctaaa cggtatgggc tgcgccagac gatcgccgat acagtaggca 2559181 tcggcgggat attcagatct ctcagaacaa tcccggtctt atttgatatc gcaaaagata 2559241 tggaggaaat gtgccctgac gcatggttct taaactatac aaatccaatg gccactctta 2559301 caggcgccat gctccgctat accaatatca aaacaatcgg gctctgccac agtgttcaag 2559361 tgtgcacgaa ggatttattt aaagctctcg gaatggagca tgacggaatt gaggaacgca 2559421 ttgcgggcat taatcatatg gcttggcttt tggaagtcaa aaaagacggc acagatttat 2559481 atccagaaat caaaaggaga gcgaaagaaa aacaaaaaac aaagcatcat gatatggtgc 2559541 ggtttgaatt aatggataag ttcggctatt atgtcacgga atcgtccgaa cataacgcag 2559601 agtatcaccc gtactttatt aaacggaatt accctgaact gatcagcgag ctgcaaatcc 2559661 cgctcgacga atatccgaga aggtgcgtca agcagattga aaattgggag aaaatgcggg 2559721 atgatatcgt caataataaa aaccttacgc acgaacgctc aaaggaatat ggttcaagaa 2559781 ttatagaagc aatggaaaca aacgaaccat tcaccttcgg aggaaacgtc ttgaatacag 2559841 ggctgatcac caaccttcct tcaaaagcgg ttgtggaagt gacatgcgtc gccgacagaa 2559901 aaaaaattac accgtgcttc gccggagaac tgcctgagca gcttgcagcc ttaaaccgga 2559961 cgaatattaa tacacagctg atgacaatcg aagcggctgt cacacgaaaa aaagaagcgg 2560021 tttaccaagc tgcaatgctt gatccgcata caagcgcgga gctttccatg aaggacatca 2560081 tctccatgtg cgacgattta tttgcagcac acggcgattg gcttccggaa tacaaataaa 2560141 aactagggga ccgctctccc ctagtttttt ggttttgttt cgccttccca ggccatcatg 2560201 ccgccttcaa cattgactgt tttaaagcct tgctcatcca ggtacttgca gacgttcatg 2560261 ctgcgcattc ctgagcggca gataaatacg tactctttgt ctttatcaag ggtttccatt 2560321 ttttcaggaa tatcccccat gcgaatatga acggcttgcg ggatcatgcc ttccgctacc 2560381 tcttcatctt ctctgacatc aattaaatat aattcttcgt ccgcctcaat tttttctttc 2560441 aaagcggctg tgctgatttc ttttatttcc aaagaaaaca ctcctattca cagtgatcat 2560501 gttcagtata tcaaagtcag ccgaacgatt gctattctga gactgatgaa aaaaaatccc 2560561 cttttggcaa aggggatttt ttctaggctt agtttgccac aatattgaca agcttcccag 2560621 gcaccgcgat gattttccga atcgttttgc cttcaagctg ctctttgacc ttttcatctg 2560681 cttgagcaag ctgttccagc tgttctttcg ttgcatcggc aggaacctgt aatttcgctt 2560741 ttacttttcc gttcagctga acaacgattt caacttcatc atccacaagt tttgtttcat 2560801 catatacagg ccaagcttcg taggcaattg tgccggaatg gccaagcttc tcccatagct 2560861 cttccgctaa gtgtggcgcg acaggagaaa gaagcttcac gaagccttcc atatattctt 2560921 tcggcagttc tgttgcttta taagcttcat taataaagac catcagctgg gaaatacccg 2560981 tgttgaaacg aaggccttca taatggtctg tgactttcat gaccgtttca tgatagacgc 2561041 gctccaatgt ttcacccgcg ccttcaacga tttttccatt aagctcaccg ctgtcttcaa 2561101 taaataggcg ccatacacgg tcaaggaaac ggcgcgcacc gtctaatcct gattcagacc 2561161 aggcgattga agcatcaaga ggtcccatga acatttcgta caatctcagc gtatcagcac 2561221 cgtgagaggc cacgatttcg tcaggattga caacgttccc tttagattta ctcatttttt 2561281 cgttgttttc gccgagaatc attccttggt tgtacagctt ttggaacggt tctttcgtcg 2561341 gcactacgcc gatatcataa aggaacttat gccagaagcg ggcatacaga aggtgaagca 2561401 cggcatgttc tgcaccgccg atatacatat cgaccggaag ccatttttcc aatttttctg 2561461 gtgatgccag ctgatccgga ttgtgcggat caatatagcg caagaaatac cagcagcttc 2561521 ccgcccattg cggcattgta ttcgtttctc ttcttccttt tttccctgtc tcagggtctg 2561581 tgacttccac ccactcttta atgttcgcaa gcggtgattc gcccgttccg ctcggtttga 2561641 tttcatccgt ttttggcaaa atcagcggca gctcctcttc cgggacagct gttgacgttc 2561701 cgtcttccca atgaatgacc ggaatcggct cgccccaata acgctggcgg ctgaagagcc 2561761 agtcacgaag acggtacgtc actttcttct caccgttttt cgtttcttcc agccaagcga 2561821 tcactttttc aatcgcttcc tgtttgtgaa ggccgttcag gaaatcagag ttcacgtgct 2561881 cgccgtcgcc agtataggct gcttcctcaa cgttcccgcc ttttacgact tccttcaccg 2561941 gaaggccgaa tgttttggcg aattcaaaat cacgctcatc gtgtcctgga actgccatga 2562001 cagcacctgt tccgtatgat gcaagaacat aatccgcaat ccaaatcggc agtttttctc 2562061 cgtttacagg attgatcgca tacgctcctg taaatacgcc tgtctttgtt ttcgcaagat 2562121 ctgtgcgttc taggtcactc tttgattgaa tttctttgat ataagcttca acagcttctt 2562181 tttgctctgc cgttgtgatg ttttccacca atgcgtgttc cggggcaagg acagtgtatg 2562241 tagcgccaaa cagcgtatct ggtcttgttg taaacactgt aaaggaatca tcatgtccat 2562301 ctatagcaaa atgaacgtga gcgccttccg aacggccgat ccagttgcgc tgcatatctt 2562361 taatgctttc cggccaatca agctcttcca agtcctcaag gagcctgtcc gcataagcgg 2562421 tgattttcag catccactgc ttcattgggc gtctctctac cggatggccg ccgcgttcgc 2562481 tcttgccgtc aatgacttct tcgttggcaa gaacagtacc gagcgcaggg caccagttta 2562541 caggcacttc gtcaacgtaa gcaaggcctt tttcgtatag ctttaagaaa atccattgcg 2562601 tccatttata gtattcaggg tcagtcgtat tgatttcgcg atcccagtca tatgagaagc 2562661 caagcgcttg aatttggcgg cggaagttat caatattctg cttcgtaaac acagcggggt 2562721 cgttccctgt gtcaagcgcg tactgttcag ctggcaggcc gaatgcgtcc cagcccattg 2562781 gatgaaggac atcatagccc tgcatgcgct tcatgcggga cagaatatcc gtagctgtgt 2562841 atccttcagg atggccgacg tgcaacccag ctccagacgg ataaggaaac atgtccagcg 2562901 cgtaaaattt ttgtttttca ttattatcaa gagtggcaaa tgttttgttt tcaagccaat 2562961 atgtctgcca tttcttttct atctctttgt gctgaaaact caaagtaaaa acctccttct 2563021 gattgaatac ggcgtgtatg gttcaagtat tgacgggaag gagaggatta tattcagaat 2563081 attcccaaac taaaaaaaac tccctcatcc caaaaaggga cgagagactt tcgttttccc 2563141 gcggtaccac cctcgttagc gcggcatacg ccgcactcac ttgatacttt taacgcagtt 2563201 atgcgtcagc ggcttttcac cgctgcaact ctgaggtgag ttcggaaaca aacttgattg 2563261 actttcacca gccgtcaact ctctgcaaca atatctgttt cttactgctc ctcttcattg 2563321 ttcttatcgc aaccgtaatc taactgtatt ttatagaatt ctgttcataa gtgcaagcag 2563381 gtttgtatac aatgggaatg taccctgaac gggcggagat tgaggacaat tattcgggtg 2563441 gagttttggt ttgacgtttg gactcggccg gttcgccgcc gctgttcagt tctctcacaa 2563501 agtcaaaact tctgagaaca gcttcaccgc cgtagcctga gataatggat aagatgacaa 2563561 gttgaattcc tgaatcgggg tcagcggata atacaagtaa aatggaagcc gtcatgccga 2563621 taaaccaatc ttccaaaaat ccaaggtaga taaaccgctt cgtcattctg ggcttctcca 2563681 gcctgcctct ctttttcaca tgaccgagaa tccccatgat tcctccaatt acacaagcaa 2563741 tgagtacctg atgcagcatc ttcatcatca ccttcctaaa gcccttattt cgtaaagcga 2563801 cttcaggcca tccagccccc ttaaacgatt ccgatgattt tcgatatcta cataccggca 2563861 aatctgtaaa aagcttgttt cttccattat atgtgaacac atgatcggta agcttgatgc 2563921 attggattca tttttcaccc agtgacattg acctagtcac ctatttagca tgtagaaaac 2563981 ctttccgttc atatgttcaa attctgttct tatttttagt gtatacgagg acaagcccta 2564041 atgacaaaca acaaactgca cttgcttgaa tcagaacatg tgttgtgcta cggttactgt 2564101 agaattcatt tttaaaaagg ggaatatcag gctttcgcat agcaagctga cggcctaagg 2564161 gggatttata tggctagttt tcaatcattt gggataccag gacagctgga agtcatcaaa 2564221 aaagcacttg atcacgtgcg agtcggtgtg gtaattacag atcccgcact tgaagataat 2564281 cctattgtct acgtaaatca aggctttgtt caaatgaccg gctacgagac cgaggaaatt 2564341 ttaggaaaga actgtcgctt cttacagggg aaacacacag atcctgcaga agtggacaac 2564401 atcagaaccg ctttacaaaa taaagaaccg gtcaccgttc agatccaaaa ctacaaaaaa 2564461 gacggaacga tgttctggaa tgaattaaat attgatccaa tggaaataga ggataaaacg 2564521 tattttgtcg gaattcagaa tgatatcacc aagcaaaaag aatatgaaaa gcttctcgag 2564581 gattccctca cggaaattac tgcactttca actcctattg tcccgattcg caatggcatt 2564641 tcggctcttc cgctagtcgg aaacctgaca gaggagcgat ttaattccat cgtttgcaca 2564701 ttgacgaata tcttatcaac atccaaagat gattatttga tcattgattt atccggattg 2564761 gcccaagtga acgaacaaac ggccgaccaa attttcaagc tgagccattt gctgaaattg 2564821 accggaactg agttaatcat tactggcatt aagcctgaat tggctatgaa aatgaataaa 2564881 ctggatgcca atttttcgtc gctgaaaaca tattcaaatg taaaggatgc cgttaaagtg 2564941 cttccgatta tgtaaaaaga tcccgctcac ccagctggat ctttcagatt gttgacaaaa 2565001 tcctaaaatg gttttcattt taggattttg tcatcttttc agcgtgattg aaaacccttg 2565061 aagtctagga aggacgagca taggagcgga gcgaatgttc taattcgtga gcaccgaagc 2565121 gcaggcctga caacgaatgc gagggtttgt cgacacgctg aaagatcccg ctcattcggc 2565181 gggatctttt attatgaaga gattgatgcc tgcttatttg tttctttagc tgattttatc 2565241 cgtttgtcat atagaagcgt tgtggcaata ctgatcagca gcaataccaa cagagataaa 2565301 acaagagccc taatgccgta atgatcgaca agcactcctc cgaacagggg accaatcatt 2565361 ctgccgcctg tcgccgcact gttgacaaag ccttgataaa agccttcttt ccctttaggg 2565421 gcaagctgat tggcaatagt cggcacagca ggccaaacaa gcatttctcc gatagtcagg 2565481 atcaccatcg cagcgagaaa catcggaaat tgctttgcag tcagcagcat gctgaaagac 2565541 acaataaaaa tgataaagcc gatgaccatt tgcgctttta gcgactcggc ccattttttc 2565601 accacaaaac tgacgagcgg ctggccgagc acaatgagaa ttccgttaac cgtccacagc 2565661 acgctgtata aggaaagaga tattccaatg ctttgtgtgt acgaagcaat tgtggttgac 2565721 cactgagaat aagccagcca tccgagtaca tagcctccgc ttaaaatgat cagtgcggca 2565781 aattttgctt tgctgttcac agcatcataa tcaagcacgg atgtttggga tgcatcgccc 2565841 gtttgaatat ttcgaaatcc gaaatataca ataaagaaaa agatcagata caatacggca 2565901 tttgccaaaa atacatatga aaacgagaaa gatgccacga caccgccaag cgctgaacca 2565961 acggccacgc ccgcgttttg cgcgacatat atcgcattaa atgccttcct tcccccttca 2566021 ggccataccg atcccgccat tgcgtagctt gccggaaaaa caacaccgga gccaaagccc 2566081 acaatcgtca gcagcacaat ataggctggc caatcatgaa aaaagacaag acccatcagg 2566141 cttgctaacg taatggctat cccaagcata atcgatttaa aaccgccgat tttatcaaac 2566201 aaaaaacctc cgcataaatt gccagccaca ctggcgccgg aattcagcat caggacaagt 2566261 ccggctactg ttaacgactt tcctaaatga ttatggatat aaatcgtatt cagcggccat 2566321 aaaaaagaag cacccgtcac attgataaac attccaatga ctaaaatttt aagagcacgc 2566381 ggcatactca tccccctttc ttacctaaaa aagctcatga aaaaaacgaa acctaaaacg 2566441 gctccgtacg aatccagtta tcatagcaca ttcattctat ctgtctctct cacatttttc 2566501 aactgatgag cgtgaaaaaa tctaacaaat attgtttgaa aaatgtaaaa taaatagaaa 2566561 aaggggtcat attatggaaa tggtattagc attcttaggt tttctggcat gtctcattgc 2566621 actgggctat ggattatatc accttgtcag atatgtactg aaaaaggaaa aacgtttctc 2566681 aaagagactt ttttggccgc ttttcattgg aggccttgtg ctgctcttta ccggggcagc 2566741 attggcagaa cctgacactg ccgcagcaaa tgccgagaaa aaatattcag cgctaaacgc 2566801 cgaatataaa aacctcacaa aagagcacga agaacttgag aaagaatata aatctgtcag 2566861 ctctgaagca aagaaattaa aagacaacaa agaagatcaa gacaagcttg agaagcttaa 2566921 aaacgaaaat agcgatctaa aaaagactca gaaatcatta aaagctgaga ttaaagagct 2566981 tcaagaaaat caaaagcagc tcaaagaaga tgcaaaaacg gcaaaggctg aaaatgaaac 2567041 acttcgacaa gataaaacaa agcttgaaaa tcaattaaaa gagacggaaa gccaaaccgc 2567101 cagctctcat gaagacactg gaagttcttc aaacaatacg agtaaaagtg atgaaaccaa 2567161 aacagctgac aaagcagaag gctgtaatat caaaggaagc agaaacggca tctaccacac 2567221 gccaggcagt acatactacg accggacaac cgatccggct gaaatgtttt gctcagttga 2567281 agaagctgaa gccgccggtt atcgggcgcc aaaacgataa acaaaaagct ccagaatgtc 2567341 tggagctttt tctgtttcac aacgacgatt taatgacctt cttataataa agaactgaca 2567401 gaaaaccaaa aatggagtag agcgcagtat ataacaccat caccataatc ataggcgccc 2567461 atacctctga tccgaataag aaccagccgg attggacggc aaagtaactg tggaagaggc 2567521 cgacaacgag cggaatgccg aagttgtaca tttgtttgat gcgtatcccc tttatcaggt 2567581 cgccctgcgt aaagccgagt tttcttaaaa ttgtatagct cggtttttca tcttcacttt 2567641 cacccatttg tttaaaataa aggatacaac ctgatgtaat caggaacgtt aaccctaaga 2567701 agccgacgat gaacatcacc ataccaaaca gtgatttttg cgcagcgctt gtatctagtc 2567761 ttgataaatg ctcgtttttc ttgttcacct gttgaaaaag ctcatttgct ttttccattt 2567821 gatcgtcatg tttcacattg acgccgataa atgtagattg cgccagctga atgcgggggt 2567881 ctttatcctt gtccagctgt ttaaacaggc tgtcatccac aatgacagcg ggcatgcccc 2567941 cgcttgtaaa cgtgtaggac acaagaaact cttctcttaa tcctttatat tttaatggct 2568001 gcgtctcgtg cttgcttttt actttaataa caccagagtc cttgaaaacc attatttttt 2568061 gcagcaagtc ggtgtatcct gagaaaacgg cttctccagc cgccacatcg actcctttta 2568121 catctttgtc gctaacaaca gcaagctgca tattgccggg atcgccctgc atctctttcg 2568181 gagttccatc cataatattt gcaatgtcaa catttgcttg caggacaggt gttgcctttt 2568241 ttacaaacga gatgttgctt tccctcaatt tgttttcaaa taacttggca tctttctcat 2568301 tcatgaatga aaaatcagcc gctacatttt gttcagcggt cttttccgac gagtaatacg 2568361 agatgtaagc aagagataac agcccgatgg cgagcgctga aacggttgta ataatcgtca 2568421 gcagcagcgc attcgatttc attctgaaca tgatcgaaga cagtgacaga acctcagaaa 2568481 tatttaagta gccgcccttg ctttttcgaa tgatattcga gataaacgta actgatcctt 2568541 tataaaacaa aaacgtcccg ataatgacgc tccccagaat gaagctcatc gcaacaaaca 2568601 gttcattaat ggtcttaaat tttccgccaa acagctcaga agacacatag tatcctgtca 2568661 aaatcaacac gatgcctaaa gcgccgatca gcatttggaa aaatgatatt ttcttcactt 2568721 tgtcttcagt ggaggacgtt actttaaaca aagataaaat actctgtttt ttgataaacg 2568781 tataattcat gatcatgatc aaaaggtaaa tgccgcagaa cacaatgacc gtttggacca 2568841 aggcctgctc agaaaaatgc agtttcgcat ccgctttgac atcgacaatt ttgaacagaa 2568901 tcatcaagac aagcttcgat atcgaaaacc cggccgctac cccgatcgct aatgaaccga 2568961 aatacagcat gacattttct gcacttaaga tgcgaaaaat tttatgcttc gtcattccaa 2569021 ttaattgaaa cagcccgatt tctttactcc gtctcttaat aaaaatcgta ttggcatata 2569081 aaatgaagat cgccactaca gccacaagca aaatcgaagc ggttttaata gccgcggctc 2569141 ccttgattga agccttcact tcgttaattg ctggatcata ctgcagcgtg acaaaggcga 2569201 aataaagcgc cacgctaaag atgagcgcaa acacatacaa atagtaattc cggagattct 2569261 ttttcaaatt tcgcaggatg agctgattaa tgttcatgct gcaccccgcc taacacgcct 2569321 tgcgttttca taatatcctg gaaaaacgtt tgcctgtcct ggcccccttt attcagctgt 2569381 gtatacattt gcccgtcctt aataaaaatg actctgccgc agtagctggc agcgacggga 2569441 tcatgggtaa ccataataat cgtcgcgttg cgtttttgat tgagctggct cagcttattt 2569501 aatagatcgg aggccgattt cgaatcgagc gcgccggtcg gttcatcagc gaaaataatg 2569561 ctcgggtcat gaataaacgc tcttccagcg gatgttctct gcttctggcc gccggaaatt 2569621 tcattcgggt atttatcccg caattcatat attcccagtt ccttggcaac ttcctcaaac 2569681 ttgcgattgg cttccttttt tgatagtttc gtgatcgata aaggcagaag gatattctct 2569741 ttcactgtca atgtgtctaa caaattgtaa tcctgaaaga taaagcctaa atgctgtttt 2569801 ctaaattcag ccagctgctt ttccttcata gccgtcatgt catttccatt aatatgaatg 2569861 gttccgtgac tgacctgatc gattgaggac agaacgttga gcaaagtggt ttttcccgac 2569921 ccggaagcac ccataatact gacgaattcg cccttttcaa tgtgaatatc gatgcccttc 2569981 agcacttcct gtttattcag cttgtttcca taactttttc gaattttatt cgcttctaaa 2570041 atcaccattt acgcagtctc ctttatattg gataatctca ttataaaaag gaatgccggg 2570101 cttttccttc gatacggcga acaaaaaaga aaagcatgtg acattttcgt cacacgctta 2570161 tgacatgttc aaattgattc cgtattggaa aggttaatgt aaaaactgtt cccgcaccaa 2570221 actccgactc aacatcaata tggatcaata acggcgccgc tgcttttttt gccaagtaca 2570281 gccccatgcc agttgacgct tgatcatggt gatccgttgt ggatgtaaac cctttatcaa 2570341 aaatacgcgg tacatctttt ggatcaatgc ccctgccaca atctttcact tggagctgcg 2570401 tctgttcccc tttttgaaag cttttgatct cgatttcaga ggcttcgctg tatttcaccg 2570461 cgtttgtcag cagctgcctg atgataaacg ccagccattt tgcatcgctc agcacttctt 2570521 tggcctcgag ctgtatgtca aaaccgatcc ctttttggat acaccacgat tgtaaatctt 2570581 tgatttcttt aaagatcaaa ggctgaagct gaatgaattc tactgacagg tcgttttcaa 2570641 taaatgaaat gcgtttttga tgaagctgct gatcaagaag caggtgaata cgcagccatt 2570701 catatgacag ctgggatttc agtgcttttt cttccattct atcaatgatt aaatgcatcg 2570761 ctgttaatgg agttttgacc tcatggatcc atgccatcag ctcatctttt tcattttcca 2570821 atgctaagcg atgccgtgct gcggtctgct tcaagtgttc tgtttgcccg gcaatgcttc 2570881 tttcaaccat tgcttcaaac ggcgtttccg gttcatttat ggctgtcaca tcgagattgt 2570941 tctcccatgt tttcaagctt ttataaaacg ctgtttcttt ccgatagcgg aaccaaagga 2571001 atatgataaa aaacaagatg cacaaataca ccatataaag tacattccca aatgatatgg 2571061 aaggatcgac aaaagcaatg aacagcatca aagcctgctg aaacaaaaac gcggcaatcc 2571121 agctccgcct ttcgataagg aatgctttaa tcatagaact tgtcctcttc cttcgcgatg 2571181 tagccctggc ccacctttgt ctcgatatat gcaccaagct gcagggcgtc cagttttttt 2571241 cgcaggcgat tgacattgac ggtcagcgta ttatcactaa caaaacgctc atcgttccac 2571301 aagcttctga tcagctcttc ccggctgacg atcttgtttt tttgctctat taattgtttt 2571361 agaatgaaca tttcattttt ggtcagttca acagatcctt tgtcattgct gacgaggttc 2571421 tgctccgcgt ctacagcagc gccgcaccac gttttaatcg tactcggctc cgtattataa 2571481 tggtgcacac gccggaacat cgcttggatt ttcgcgatca gcacatcaaa atgaaatggc 2571541 ttttgaataa agtcatctgc cccgagctgc atggacatca ccatatcagc aggatgatcc 2571601 cgggaggata aaaagagaat cggaacattt gaccgggagc ggatcagacg gcaccaatga 2571661 aagccgtcaa atttaggcag ctgcacatca ataatgacac aatcaggatt aaccgccgca 2571721 aattcctgca gcacctgact gaaatcctga atgccgtata catcatagga ccatcccgtt 2571781 aaacgatcct tgatttcatg aaacagcgat tcatcatctt caatcagcaa aagtttaaac 2571841 aatcgactca ccgcactttt tcctttttta tcaagtgtat agcaaaacgc cagcatgcgc 2571901 tatagaaaaa gccggctgtc tcagccggct cgttcgcatt ataattctct tctcaacgct 2571961 gtcagcacgt tggttttggt agcttttctc gccgggttca ttccggaaat gactgcgacc 2572021 cctccgcaaa tcacaacggc aatgatcaca aggctcgccg ggatgtagga gaatgtgtaa 2572081 ttcaaatcgc ccgcatcgcc accgcttgtg gccgcaagaa tcatcggaac ggccaggttg 2572141 acaaggtagc tcacgccgta agaaatgata atcccaatca cacagcctaa aattccgata 2572201 tacgcgcttt ccatcaagaa cattcggcga atgattgacg ggctcgcccc aatcgctttc 2572261 ataatgccga tctcttgcgt tctctctgtc accgccatcg tcatcgtgtt aaaaatgccg 2572321 atcgctgaaa tgataactgc gatacatccg acaaagatca gtccgatttt gaagaccatg 2572381 aagaaggtat tggctccctc aagttcagta gtcactgatg tgacatagta cccgtcatct 2572441 gttagatcat ttgtcagctg ttccacattc tcaaacttat cagcaaaaac accaatgttc 2572501 gtttcaacat ttccgccttt gaaatctaag aattccgaaa aatctttttt gaattgatca 2572561 ctgataaaaa tatttgagtc ctccatccag tcttgagatg gtttttttgt aataccgaca 2572621 attttaaagt catatgtttt tgtttttgta acatcccctg ttttagaatc tgtcttcgat 2572681 acacttagtt caattgtttt atttagaata tctttcgtat agccctttgg ttcttttata 2572741 tcttctggat ttccttttgc ttcctcgatt tttttgttat attcttccga ttcttttttc 2572801 gttaataatc tctttgcgaa gtcgtatcct actacgattt cattttccga ctttgcgact 2572861 cttccctttt ccaattccat attggccttt aattcatcat tcatattagt aaaaatgaga 2572921 tttgagcttt catttgtacg attgcctaaa gtagctttgt ttggttcata cacttgcgtt 2572981 ctttctacaa ctgaccttac gtgatcatac ttctctaaat cagctttttt aatcggcttg 2573041 tctccttcct tgcccattac gctgactttc gttacaatct gctggctcat tgtcatatct 2573101 gtaatcgtct tttgaatccc aaatccaacg gacgacaaca caaccaaaaa cgcacacgcc 2573161 attgttgtcg ccagaatcgt cataaagacg cgaagcctgt ttttcttcat atttcttctg 2573221 ataaaatgaa cctgatcctt aaacctcaac ggtaattcct ccttttagca caccatcatg 2573281 aagctgaaat tttgaatgtc cgatagaagc gacttcatca tcgtgagtaa tgatcacaaa 2573341 tgtaatgcca cgctcacgat tcagctgctg gatcaattcc agcacttcat gttccgtttc 2573401 tgaatcaagg cttcccgtcg gctcatccgc taagataatc gaaggattta aaatcaatgc 2573461 tcgagcaata ctgacacgct gctgctggcc gcctgacagt tcattcggat aatgagcggc 2573521 gtggttttcc agaccgacgc gtttcagcat gtcctgcacc ttttgcttcc gctcagatgg 2573581 cttgattcct tttaacgcca gcggcatttc cacattctca tacgtcgtta aacccgggat 2573641 gagctgaaag ctctgaaaaa taaacccgaa atggtcaagc cgaaattgcg cccattcctt 2573701 ttcattaaac cccgtaacat cagtgccatt aatgacaatc cgcccttttg tcggcgatat 2573761 gtagccggaa attaaattca aaagcgttga tttccctgag ccgcttcgtc cgacaatgca 2573821 ggcgatttcc cctttcgcca cgctcaatga aacatccttc aatactggaa cttcattctc 2573881 acggcccttt tttccgatcg tgaaagaatg gtcgatatgc tgaacatcaa tcatatgttc 2573941 tctctccctt acaaaagttt cattttttta taaatcgcaa aataactaat caagaaaccg 2574001 attaccgcac ctgtacccat gccaatgaga taaccggcaa agctctcgct tgcagtaaat 2574061 ccaaaatagc cgaagcccat gattcctatg ataataacga tgatctgcac cgggcggtta 2574121 agcggcttcc ataagaagaa atatccgttt ctttcattag acattttaac aaagctaata 2574181 tagccgatga tgtaaaaaat gatagtcatg atagccggaa tgactaaata atatggtgaa 2574241 ttctcagccc atttcgagtc tacataaatt atcggaatga aatactgcac ccatttaggt 2574301 actggaccat ggataaaatc tattgatccg ccaaaaagga tctcgaggtt gatcacaggc 2574361 aggctgatga gtaaaaacgg cgaaatggcc acggtaaatg agactagaag ctgtgcgaaa 2574421 ctattgcctg tcaaagctcc tccggccata accaaagaat aagccagcat gctaacaata 2574481 atcattccca agctgtaatt gtgaaaataa acggcctgat ctggcttcaa aagcatgatc 2574541 agcaaaacag acaaaacata acctatgagc tgcggcacca caatcaccat tccgccggta 2574601 aggaacttcg catgaaatat ctgccctcgt gtatatggaa ggcttaatgt aaaatcaaag 2574661 aagctcttgc tacgttcaat cccaagctgg ctgaccgcca aaacgactcc ccaaatccaa 2574721 aacaatgaga taaatgagct atttaaataa tcaacgctga atacgcaggg gccgacccaa 2574781 ttttcttttc cagtgacaca gccttgatag atgagataca tatttaaaat tgataatgga 2574841 ttacctaata taaaaaccaa aatggtgata actaaggcga ctttattctg ccgccactct 2574901 ttgtaaagca gtccggaatc cggcaactca cttccctcca aacctaaggc atttcttaca 2574961 cttttgtttt cttataaata gagaagtagc tcacaaagaa tccagccact gctccaatga 2575021 tcatacccaa aatataacca ataatggaat gtccggtata gtatccaaat aaaccaaatc 2575081 caaggatgcc gaaagccata accagaattt gcaccgggcg atctaatctg ttccataaga 2575141 aaaagtgtcc gttccgttca cttggaagct tcttgaagct tataaagcca atcaagtaaa 2575201 atagcatgct cattacggct ggaatcaata aaagatattt actgttaatc agccattcat 2575261 ttacaacgta actaatcggt actaggttcg ataaattgct tgccagagag aaataactct 2575321 caggggaagg gaatatttcc catatattcg caccaaaaac aacttctagg tttccaaccg 2575381 gcaatgcaat aattaaatac ggcaatatag ctgctgaaaa cgccgttaac agttgggcaa 2575441 aagcatttcc agttaacgct ccggcggcca tcaccagtga aaaagccata aaacttatca 2575501 cgattactcc aatgctgctg tgctcaaaaa agtagacgtg ttcagggtta tagacaagaa 2575561 tcagcagcca tgcaagtaaa aagccaatca attgtgacag cacaatcaca aaaccgccta 2575621 accaaaattt tgtctgaaaa atttggcttc tgttatacgg gaggcttaat ataaaatcca 2575681 tcgtgccttt cgaacgctcc attccgagga agcagaccgc caaaatgaca cccggcaccc 2575741 agttgatatc tatcagattg cttatggaat aattcacaat aaaatcacaa tattgcgggt 2575801 cttggcgatc aagacaccct tgataagaca aatacgtatt aacgatagaa agcggatttg 2575861 ccaatactaa aaacgcgata cttaacaaaa tcaccacttg attctgcttc cactctcgat 2575921 agaggagacc tcggtctacc atctccgctt ccctccaaac ttcgcaatga acacttcttc 2575981 caggttgaca ggaagctcat tccacacttt tggcttcagc tctctcaaaa agctcttttt 2576041 ctcctcatcg cttttcggaa tcagcactgt gtaaaacacg ccggcctgat cgagcatcgg 2576101 aatgttttgc tctctgatgg ccaaattgac atctgtatcg aaggccattt gaattttaat 2576161 gtattcttct tttaactcat caagatccat gacgttggtc aggctgttat cttcaagaaa 2576221 accaattcgg ttgcacatcc gctctatgtc ttcaagccgg tgggacgtaa tcaggatgct 2576281 cgtatcacgc tctgccactt catcgaccat cagctgcagc acatcatgcc ttgtcaccgc 2576341 atcaatacca tccgtcggct catcaaggag gatcagcgcc ggtctcgccg caaacgacag 2576401 aacgagcgat agctgctttt ttaagcctgt cgacagctca cggtattttt tcgtttccgg 2576461 aatttcgtat ctgttcatca gctcattcgc gtacgtgaca tcaaatttcg gatatattct 2576521 tctcaaaata tcgactaact gcttgtatgt atacttatcg taaaacggat tttgaacagg 2576581 catgtagatg atattttgtt tgactttcgg gtgctttttg atttctacgc cgtcaaataa 2576641 aatcgttccg ctgtcagcga aaatgatttg ctggattaag cgaagcatcg tcgttttgcc 2576701 cgatccattg cgtccaagca atccaaagat ttctcctttt tcgattgtta atgaaacatc 2576761 ttttaatact tgattgccgt caatcgcttt tgacagctgc cgcagttcaa tcattttttt 2576821 tgcctccctt cacatcagcg ctgatttcct ttatccattc gtgcagtttt tccagctcaa 2576881 cccctgcata gtgtgcatcg atgatgagct gtttgagttg ctctttaatc atcgtcatct 2576941 tcccttcaac cagtgtcgtt tttgcattct ccgatatata ggtccctctg ccccgcagcg 2577001 tttcaataat cccctctcgc tcaagttctt tatacgcttt gctgacagtg ttcggattcg 2577061 caataatgat cgttgccaat tctctgacag aaggaagctt atcaccaggc ttcatgatcc 2577121 ctttcaaaca aagctctttc atttgctgaa taatttgttc gtaaatgggt gttgagcttc 2577181 ttggatcgat ttgaatcatt tacttcccta ctttctatac gatctgaacc ttttatagat 2577241 aaaaatgatc aattatactt ttttgccatt caaaaccgat catcacaaga acaagaaaaa 2577301 aagaacaagc gatcacagat gccgcaatca gcattggcac gttacgtttg tttcgttttt 2577361 tatgtttcat aactgcctcc cttaatgtca atatataaat gattttatat tagtgtctat 2577421 agtgtattac ttcaattagt acacttaata caataaatac tttgactcac aaagtcaatc 2577481 ctttttttac aaaaaaacgg acccttttaa aagggtccgt tttcctacac atcaagaggg 2577541 tgctgcagga tcatattatt ttgcaaagat tgaagctgaa gtctcattct gtacagctgt 2577601 tctctctgct gatcatttga cgacagccat agtttattca aggcatttac cgcatcttct 2577661 agctgcattt gtgcatcact atattcttga tcgttataat gctcttgttt agaagcgatt 2577721 ttcagctgtt cttcagcata atcataggcc tgcatacatt gctggagatg ttcatctact 2577781 gattgtcttg ttgccacagt aacccctcct cttggtaatg gaaatcatcc atcattcata 2577841 ttgtagcctc atctgacttt attcaataaa gtaatttatg gtcgatattc atttgttctc 2577901 ttgtgaaatg cgtgctacaa ttttaggatg caatcgtacg caaggaggca catgaattgt 2577961 gatgcagaac aatccttttc cttattcaaa tacggaaaaa cgctatcata cattgaatta 2578021 tcatctcaga gaacatttcg gccataaggt gtttaaagta gcgcttgacg gcggttttga 2578081 ctgtccaaat cgggatggca ccgtagccca cggaggctgt acgttttgca gcgcagcagg 2578141 ctccggagat tttgctggaa accggaccga tgatttaatt acgcaattcc atgacatcaa 2578201 aaaccgcatg cacgaaaaat ggaaggacgg caagtacatc gcttattttc aggctttcac 2578261 aaacactcac gccccggttg aggtgcttcg tgagaaattc gaatccgtcc tcgccttaga 2578321 tgatgtggtc ggcatttcga tcgccacacg cccggactgt ctgcctgatg atgtcgttga 2578381 ttacttggca gagctgaatg aacgtacgta tttgtgggtg gagcttgggc ttcaaacagt 2578441 tcatgaacgg actgcacttt tgatcaaccg cgcacatgat tttaactgct atgtggaagg 2578501 cgtcaataaa ttaagaaaac acggcatacg tgtctgctcg catattatca acgggctgcc 2578561 tttggaagac cgggacatga tgatggaaac ggcaaaggcc gtcgcagatt tggatgtcca 2578621 gggcattaaa atccatctgc ttcacctact gaaaggcacg ccgatggtca aacaatatga 2578681 aaagggcaag ctggaatttc tttctcaaga tgattatgtg cagctcgtct gcgatcagct 2578741 tgagatcatt ccgcctgaaa tgatcgtcca ccgcattaca ggtgacggac cgattgagtt 2578801 gatgatcggg ccaatgtgga gcgtcaacaa atgggaagtg cttggcgcca ttaataaaga 2578861 gctagaaaat cgaggcagct atcaaggaaa gttctttcaa cggcttgagg aggaatcagc 2578921 gctatgattt tgaagaaaat tcttccttac agcaaagaac tgctgaaaat ggccgcggga 2578981 gagggagata ttgtcgtaga tgcgacaatg ggcaacggac atgatacaca gtttttagcg 2579041 gagcttgtcg gtgaaaacgg ccatgtatac gcattcgaca tccaagaatc agccgtggcc 2579101 aatacaaagg aacggctcgg tgacatgtat caagcgcgaa caacgttatt tcacaaaagc 2579161 catgataaaa tcgctgaatc cctcccgcct gaaacacatg gcaaagtggc ggccgcggta 2579221 tttaacctcg gctatttgcc gggcggggac aaatcaatta cgacaaacgg cagttctacg 2579281 atcaaagcca ttgaacagct tctcagcatc atgaaagacg aaggtctgat tgttctcgtc 2579341 gtctatcatg gccacccgga aggcaaagct gaaaaaaacg acgtgctcga gttttgccgg 2579401 gacttggacc agcaaacagc ccgtgtatta acatacgggt ttatcaatca gcaaaatgac 2579461 ccgccattta ttgtcgccat cgaaaaaaaa gctcagatca gcaaatgatt tgagcttttt 2579521 tctttgaatt tttcatccag gacatttttt gaaatttccg gtaggctctg ccgttgatat 2579581 aaaagaaaag ggaggttttt ccgctggctt tgatcagctt ctttgcgagc cggacctgct 2579641 tcgtcttact ttaccatttt tcaaattata tttgaaagca ataaccatcg ttaacccgga 2579701 cgtcatacag ttcgggtttc gatttttcca taaaacgttc acatatagca tgaaacgtat 2579761 gacttttatc ttatcacaaa actataaaca gcctctgcaa aaacacatac ctattctttc 2579821 ctgttctcta ttttctatga gcacacacaa aaagagccca ctgggagctc tttttgtcag 2579881 ctgatatttc gttcgctggc agcagccgca ttttttttat gaaacccttt tccatagtac 2579941 acagccagca agatgagaaa ccatatcggc ccgataatca cggctactct tgtatcaggg 2580001 ctgtaagcca taagaatgac gacgaatgct agaaatgcca atgacacata agacgtaaac 2580061 ggaaataaag gcattttgta ctttaattgt ttcttttctt ccggcttcaa acttttcctg 2580121 tattttattt gagaaagcaa aatgattgcc cacgtccaaa tcgctccgaa cgtcgcaata 2580181 cttgtaaccc aagtaaatac cttcgcaggg acaacatagt ttaacagcac tccgactaat 2580241 aaagcgcccg ctgaagccag aacagcttta cccgggatgc cgcctttcgt cagctgacca 2580301 tatgcttgtg gcgcctcttt ctgttccgcc aagttaaaca gcatccgccc tgtgctgaaa 2580361 ataccactgt tgcatgaaga cagcgcggct gtcaacacga caaagttaat gatacctgcg 2580421 gccgatggaa tgcccacttt ttgaaatgtg agaacaaatg gacttccttg agagccaatt 2580481 tcctgccacg gataaataga cataatgaca aataaagcgc ctacataaaa aatcaaaatc 2580541 cgccaaaata ctgtatcgat tgctttggct aacgattttt gcgggttttt tacttcgcca 2580601 gccgtcaccc cgatcatttc aatccctaaa taggcgaaca tgaccatttg aagagacaat 2580661 aaaacccctt ttaatccatg agggaaaaat cctccgttgt tccacaaatt gctgattccg 2580721 gttgcaatgc ccccattgcc gactcctgca ataatcatca ataaaccgac agcaatcatg 2580781 gataagattg caacaatttt aatcaatgcg aaccaaaatt ccagctcgcc gtaagctttg 2580841 acagccagga aattaacacc cgtcataatg accagtgccg ataacgccca aatccagttt 2580901 ggcacgtccg gaaaccagaa ccccatatag atgccgacag cagtgatttc ggccatacag 2580961 gtgacaaccc ataaaaacca gtagttccaa cctgttaaat agcctgcaag cggtcccaaa 2581021 taatcacgcg catacctgct gaaggagcct gcgaccggtt tttgaatggc catttcccca 2581081 agcgctctca taataaaaaa catgaccagg ccgcttgcgg catacgctac caaaatacca 2581141 ggccctgcta attgaatagc tgatgcggag ccgaggaaca accctactcc tatagcagct 2581201 cctaaagaca ttaaagaaat atgcctttct tcgagtccgc ggtgcagctc ttgtttttgt 2581261 ttttgcatgc ttcttctccc ctagaaaaaa atatcattat atcatttttc tgaatattcc 2581321 gtacggattg ggtaaatcaa tgatgatgga gaaataaaag gataacaaca aggctttcga 2581381 ctactcgaaa gccttgttgt ctgttacaca aagatgactt ctttaggctg atggctcagc 2581441 tcttcaggca tataccgttt ttcaatattg atgctgtgcc agatcataaa gattagcaca 2581501 gtccaaattt tacggctgtt atcagccttg tccgcacaat ggtcttcaag aagctgaagg 2581561 acataatcct tatggatata agcatccgtt tggctttctt gaataatatt ccgcacccat 2581621 tcgttcattt cgtttttcag ccaatgacgg atcggtacag ggaaaccaag ctttttgcgg 2581681 tttaatacgt gctcaggcac aattccttca gcggctttgc gaagaagata cttcgtcgtg 2581741 ccgttcttcg ttttcagctc atcaggaatt tttgaagcga cgtcgaatac gactttatcc 2581801 aagaacggca cacgcagttc caaagaattc gccatcgtca ttttatccgc ctttaacaaa 2581861 atgtcgccgc gcatccaagt gtggatatcg acatactgca ttttgttgat atcgctgtac 2581921 gagctgcttt ctgtaaagta agtcttcgtc acatcgcgat atgaaaggtt cggattataa 2581981 tgcttcaaca gctgcttttt gacagactct tcaaagattt tcgcgttacc gatataacga 2582041 tcctgaagcg gagtgcagcc gcgctcaagc aggctcttcc ctctcatacc ttcaggcata 2582101 acggcagcaa cgtgcagaag catctttttc aagccggacg gaatccgttc aaacggttta 2582161 agcgaaagcg gttcacggta aatgttatat ccgccgaaga gctcatccgc tccttcacct 2582221 gataaagcaa ccgtaacatg tttttttgct tcttttgcaa caaagtacaa cggaatcgct 2582281 gccggatcag caagcgggtc atcaaaatgc catacgatct tcggaagctc attcatgtat 2582341 tcctcaggcg aaatgacttt gctgatattt tcaatgccca gcgccgctgc cgtttctttc 2582401 gctacatcaa cctcactgaa gccctgctgt tcaaagccga cagagaatgt ttttaagctt 2582461 ggatgaaatt ccttcgcaac agacacaata aaggaagaat caatcccgcc agacaggaac 2582521 gaaccgacag gaacgtcact tctcatatga acgtttacag agtcatagat cgcgtctcgg 2582581 acttctttca caagcttgtc ttcttcagtc tgaaccggct tgaagttcgc tttgaaatac 2582641 gttttgaatg tgatatcgcc gtccgggcgg attgtgaatt gtgaacccgg ctctactttt 2582701 ttcacatggg catcaagcgt gcttggttca ggaacaaatt ggaaagacat gtactgctgc 2582761 aatgcctctt tatctatttc aatatcattc tgagcaacca ttaaactttt tctctctgag 2582821 gcaaaataaa cctgatcatt gatcgttgtg tagtacaacg gtttaatgcc gaatggatct 2582881 cttgccccat aaagcacatg atcgttttta ttccaaatca gaaaggcaaa cataccgcgc 2582941 agtttggacg ccgcttcttc tttatagtga cggtaagtcg caagaagaac ctctgtgtcc 2583001 gaatccgtgt tgaatgtgta cccctttgct tcaagttctt ctctcagttc gatatagtta 2583061 tagatttctc cgttaaagat aatccaatat gtttcatctt catatgataa aggctgtcca 2583121 ccattttcta catcaataat gctgagccgt ctgaatccga agccgacgtg ctcatcatgg 2583181 aaatatccat cactgtcagg accgcggtga acgatcattt ggttcatttg tttgattagt 2583241 tcttcttgat cagcggtttg agctaacgga tgcttgttaa aaaccccgac aaatccacac 2583301 atagtattgc ctccataatt aaaattgtca tcattgaacc cctatttata gacgctgtga 2583361 atagtatttg gtttcacagt tatgtaaaaa aataaacatg aatacaacga taaaaaaggg 2583421 aaagccgctt aaccagtaag cggctataaa attattctcc taacgcttct ttacgcagct 2583481 gctccgcttt gtctgtgcgc tcccatggaa ggtcaacatc gtgacgtcca aagtggccgt 2583541 acgcagcagt ttgtttatag atcggacggc gcaaatcaag cattttgata atgccggcag 2583601 gtcgtaaatc aaagttattg cgaacaactt caatcagttt ttcctcagaa gcttttcctg 2583661 aaccgaatgt gttgattgag attgacacag gctgtgcaac accgatcgcg taagcaagct 2583721 gtacttcgca agaatcagca agctcagccg caacgatgtt tttcgcaacg tatcttgccg 2583781 cataagctgc agaacggtct accttcgtcg cgtccttacc tgagaacgcg cctccgccgt 2583841 ggcgtgcata gccgccgtac gtatcaacga tgattttgcg tcctgtaagt cccgcatccc 2583901 cttgagggcc tccgattacg aaacgtcctg tagggttgat gaaatatttt gtttcttcat 2583961 caatcagctc ttcaggaaca accggattga ttacatgttc tttaatgttg cgctgaattt 2584021 gctcaagtgt aatttcaggg tgatgctgag ttgaaataac aatcgcgtca atgcggactg 2584081 gtttgttatt ttcatcgtac tcaaccgtta cctgtgtttt gccgtcaggg cgaaggtacg 2584141 gaagaatatc ttctttacgg acttcactta ggcggcgggc taatttatgg gcaagtgaaa 2584201 ttggaagagg cataagctct ttcgtttcgt tgcacgcata accgaacatt aatccttggt 2584261 cacccgcacc aatcgcttca atttcttcgt cgctcattgt gccttcacgg gcttcaagcg 2584321 cttggtctac gcccatcgcg atatcagcag actgctcatc aattgatgtt aaaaccgcac 2584381 aagtttccgc atcaaatccg tattttgcac gtgtgtatcc gatttcttta atggtttggc 2584441 gaaccgtttt cggaatgtca acatacgtag aagttgtgat ctctccgctt acaagaacca 2584501 aacctgttgt cacagatgtt tcacaagcaa cacgcgcgtt agggtctttc tttaaaattt 2584561 catctaaaat gctgtcagaa atctggtcac agattttatc cggatgcccc tccgtaacag 2584621 attctgatgt aaataaacga cgatttttac tcatgatttg cttcctcctg cacaaggcct 2584681 cccgaaagac cttgtatata tgatacggaa ctcgctccct cttatacaat gtacagttat 2584741 attagagaat gttaattggc atatttatga aataaaaaaa ccttttccat cgaggaaagg 2584801 gtttggtctt tgtgcctttc actcttatcg ctcaaggaat catacaacct tgcaacaggt 2584861 tagcaccttg gttgtctcac tcagttgaac ataataaata acagagaaac cggttgctgg 2584921 gcttcatagg gcctgtccct ccgccagctc gggataagag tatccgctca atgaaatatc 2584981 ttatcgtaaa agggtttgca atgtcaatat gattcagaag aaataggcac ctatattgag 2585041 ggaaaacaat ggaaatgcac acacaaaaaa caataaatag tatagactat ttgaaaatat 2585101 atgttatact aattcacaat tagcaaaaca caaaaaacga taaaggaagg tttcatatga 2585161 actcagttga tttgaccgct gatttacaag ccttattaac atgtccaaat gtgcgtcata 2585221 atttatcagc agcacagcta acagaaaaag tcctctcccg aaacgaaggc attttaacat 2585281 ccacaggtgc tgttcgcgcg acaacaggcg cttacacagg acgctcacct aaagataaat 2585341 tcatcgtgga ggaagaaagc acgaaaaata agatcgattg gggcccggtg aatcagccga 2585401 tttcagaaga agcgtttgag cggctgtaca cgaaagttgt cagctattta aaggagcgag 2585461 atgaactgtt tgttttcgaa ggatttgccg gagcagacga gaaatacagg ctgccgatca 2585521 ctgtcgtaaa tgagttcgca tggcacaatt tatttgcgcg gcagctgttt atccgtccgg 2585581 aaggaaatga taagaaaaca gttgagcagc cgttcaccat tctttctgct ccgcatttca 2585641 aagcggatcc aaaaacagac ggcactcatt ccgaaacgtt tattattgtc tctttcgaaa 2585701 agcggacaat tttaatcggc ggaactgagt atgccggtga aatgaagaag tccattttct 2585761 ccattatgaa tttcctgctg cctgaaagag atattttatc tatgcactgc tccgccaatg 2585821 tcggtgaaaa aggcgatgtc gcccttttct tcggactgtc aggaacagga aagaccaccc 2585881 tgtcggcaga tgctgaccgc aagctgatcg gtgacgatga acatggctgg tctgatacag 2585941 gcgtctttaa tattgaaggc ggatgctacg ctaagtgtat tcatttaagc gaggaaaagg 2586001 agccgcaaat ctttaacgcg atccgcttcg ggtctgttct cgaaaatgtc gttgtggatg 2586061 aagatacacg cgaagccaat tatgatgatt ccttctatac tgaaaacacg cgggcagctt 2586121 acccgattca tatgattaat aacatcgtga ctccaagcat ggccggccat ccgtcagcca 2586181 ttgtattttt gacggctgat gccttcggag tcctgccgcc gatcagcaaa ctaacgaagg 2586241 agcaggcgat gtaccatttt ttgagcggtt acacgagtaa gcttgccgga accgaacgtg 2586301 gtgtcacgtc tcctgaaacg acgttttcta catgcttcgg ctcaccgttc ctgccgcttc 2586361 ctgctcacgt ctatgctgaa atgctcggca aaaagatcga tgaacacggc gcagacgttt 2586421 tcttagtcaa taccggatgg accgggggcg gctacggcac aggcgaacga atgaagcttt 2586481 cttacactag agcaatggtc aaagcagcga ttgaaggcaa attagaggat gctgaaatga 2586541 taactgacga tattttcggc ctgcacattc cggcccatgt tcctggcgtt cctgatcata 2586601 tccttcagcc tgaaaacacg tggaccaaca aggaagaata caaagaaaaa gcagtctacc 2586661 ttgcaaatga attcaaagag aactttaaaa agttcgcaca taccgatgcc atcgcccagg 2586721 caggcggccc tctcgtataa aaaacaaaag ccaagagcaa ttatgctctt ggcttgtttt 2586781 aattgacgga atgcaaagaa gtcagcttgt atgtaatgat ggtccggcct tcttcccatt 2586841 gaagcttctg cacttcagct gtgcctgact tttcgccaaa ctttgttttg cgtacatcca 2586901 ttggaatctc catcggatat actcggtatc cgtccttctc taacgtgaat atattttcat 2586961 ctatgcgaac ttcttttcct tttgtcacaa tcagtgtatt aaattcaaca ggcattccca 2587021 aagtgaaatc ccctttcgtt ctcttttttc tttatcataa catatttcac tgtcagcggt 2587081 ttttcatcca ttgtgtgagc tgccgcacga tacgccggtt ttcttttggc gggaaataat 2587141 gtgtgaatgt actgtagtac catgtttcca ccggcttatg cagttgtttt agcttctctt 2587201 ctaataaata ggaatgctga atcgaaacat tttggtcttt ttctccatgg attaacagca 2587261 cgggagcctg aattttgttt acttggtcaa acggtgtcct ccattgatat tcctcaggca 2587321 cctttttcgg tgttccgccg atgactcttt tcatcattcg ccgcaaatcc tgccgctcct 2587381 cgtatgtaag aatcatatca ctgacgcctc cccaggaaac aaatgaagct gcctgcccgc 2587441 ccatttcgat cgcagtgagc attcccataa ttccgccgcg ggaaaaaccg aagatatgga 2587501 ttctatcctt cttgacattt gggtgctgct gaagcaggcg aaaagcagaa aatgcatcct 2587561 ccctgtcttc tccggcaaaa tcctcattgc cttctcctcc ttgattgcct ctgtaaaaag 2587621 gagcaaacac cacaaaccct tgggatgcaa actggataat ccggcccggc cgaaccatgc 2587681 ccacgctttt aatcccgccg cgcaaatata aaaatccgtc atattgtccc ggttccgccg 2587741 gctcagccag aagcccctta acccgtaatc catttgacag atagcagatc gtatacaaac 2587801 gcacatgctg gcttggcgac ggaaatcttc ttttctctac aatcaaaaca gccgcctcct 2587861 tttttctata tgctttcctt actccaaaat tacatccgga gaacctggtt aggcattcac 2587921 acatttttat acccatcata cgatatgtaa agcaaaaaag gatattaact tgatgcgaaa 2587981 taaggaggtt gtctatgtga acagatggtt aaggctgggc ttcgcctgtg tcggcagtat 2588041 ctttctgatg ttcgccctgg cggcttgcaa gcaggaagaa acgctcacca aagtcaaagt 2588101 agctgaagtg acccattcaa ttttttacgc acctttatat gttgctgagt ctaaaggttt 2588161 ttttaaggaa gaagggcttg atgtcgatgt gaatacgacc tggggcggag ataaaacgat 2588221 gacatcgctt ctttccaacg gctccgacat cgcgcttgtc gggtcagaaa catctattta 2588281 tgtcgaagcg caaggggcta aagatcccgt cattaatttc gcccagctga ctcagacaga 2588341 cggaacgttt cttgtcgcga gagaagatgt tgaacacttc gactgggatc agctgaaagg 2588401 aaaaacgttt ctcggtcagc gaaaaggcgg catgccgcaa atggtcggcg agtatgtact 2588461 gaacaaacat aagattgacc cgcataagga tatagacctc atccagaaca tagacttcgc 2588521 caatattgcc aatgcgtttg cttctggaac cggtgagtat gtacagctct ttgaaccgca 2588581 ggcttctctc tttgagaaaa aaggcatcgg ccatatcgtg gcttcattcg gagaagaatc 2588641 aggagaggtt ccttatacga cttttatggc gaaacaaagc tatttgaaga aaaatgaaga 2588701 cacagccgtc aagtttacaa aagccattta taaggcgcag cagtgggttg aaaatcattc 2588761 tgcgaaggac atcacagatg ccattaaaga tgaatttgat gataccgacc cagacgtcat 2588821 cgaaacatcc attgaacgct ataaaaaaca gcattcatat tcaccagacc ctctgcttaa 2588881 cgaaaaagaa tgggagcttc tccaaaccat tatggataaa tcgggagaac tgccgaagca 2588941 cattccatac aatcagcttg taaataaaga aattgctgaa aaagtcacct cggagaaata 2589001 ggaggcgcca tctatgtctt tcttacatgt cgaccatgta acccatactt atttttctat 2589061 taaagaaaaa acaacggctg tgcgggatat tcatttcgat gccgaaaaag gcgatttcat 2589121 ctcatttctc ggcccaagcg gctgcggaaa aacaacattg ctttccatta ttgccggttt 2589181 gattgagcca tcagaaggca gagttctgat tgaaggccgt gagccgaatc aaaaagaaca 2589241 taatattggc tatatgcttc agcaggatta cttatttccc tggaaatcta tcgaggaaaa 2589301 tgtgcttctc ggtttaaaaa tcgccgacac gctgacagaa gaaagcaaag ccgctgcact 2589361 cggtctattg ccggagttcg gcctcataga tgtggagaaa aaatatccga aagaactgtc 2589421 aggcgggatg cgccagcggg ctgcgcttgc aagaacactt gcgcctaacc ctagtctgct 2589481 tttgctggat gagccatttt ccgcgcttga ttttcagaca aagctgtctt tggaaaacct 2589541 ggtattccgc acattaaagg aatatcaaaa aacagcagtg cttgtcactc atgatatagg 2589601 ggaagcgata gcgatgagcg atacgatctt tttattttca aatcagccgg gcaccatcca 2589661 tcagattttt accattccta aggaattggc cgcgatgttg ccttttgacg cccgtcagga 2589721 accttccttc cagacactgt ttcaaacgat atggaaggag ctgaattctc ttgagaaaca 2589781 gcaaagaaac cattgatctg cttcacgagc agtatcaatt caaacagaaa aaggaaaagt 2589841 ggaaggtcca ttcctttcag cttgccatat ttattctctt tttctcgggc tgggaaatct 2589901 ccagcaggca gggctggatc gatccgctga tcttcagctc tccatcagct gtgtggcgat 2589961 tattgctgga gaaacttggt gacggttctt tactgtcaca catcggcgtc actttatttg 2590021 aaacggtgct tggctttttg ctcgggacgt ttatgggcac gtgcctagcc gctttgttat 2590081 ggtggtctaa ccgacttgcc agaattttag atccgtatct tgtgattttg aacgcaatgc 2590141 cgaaagtggc cctgggcccg atcctgattg tcgcgctcgg tcccagtttt atcagcatca 2590201 ttgcgatggg agccatcatc agcgtcatta tcacaaccat cgttgtctac accgccttcc 2590261 aagaggtcga cgaaaactat acgaaagtca tgaaaacatt cggcgcaaaa aagtgggtta 2590321 tttttaaaga agtcatactg cctgcatcct cccccgcgat tatttcaaca ctaaaagtga 2590381 acgtcggttt atcatgggtt ggcgttattg taggggaatt cctcgtttcg aaggtcggat 2590441 taggatatat gattatttac ggattccaag tcttcaattt tacactcgtc ttcttaagcc 2590501 tgctgatcat cgccatcttc gccactctga tgtatcaggg cgtcgagctg ctggaaaaga 2590561 aatggacgaa ggggaggaca taaaaaaccc ggcacatgtg ccgggttttt tattcaatcc 2590621 atccagattc tttcagtttt ttcaagctga tcggaagaac ggaatccttc ataataaagc 2590681 tgaatttttt attgcgggaa aggttctccg gcagctcgtg aaacaaaacc gggcctttcg 2590741 tttcaaagta atcagcctgc ttttcaagct tttctatatc tgcaaaatat atatttttta 2590801 caatcacttt ttcttttccg agaactttat actgtccgag atacttgagg cttttgactc 2590861 tcgcgcccgt ctcttccttt acttcccgga gcgcagcctc ttctgcgcac tccatcggct 2590921 ctactttccc gcctggaaac tcatagcctc tgtcctcatg ttctgttaaa agccatttgc 2590981 cgccaaaacg gcaaatcacc cagacatgct tcgggctgtc cgagaaaggc tgatcgtcaa 2591041 aggaaagctg aacagtattc tgataataat ctttaaactc gtacatgttt atccctcaaa 2591101 tccgttccta gctatcttcc atacatcata ccacagttac gtttcttcgg aagcctttta 2591161 tcaaaaaata agggaaaccc agcacgccgt caggttctgc atgcagacta gctcgtacag 2591221 tttttttgcg atacttttgc cggaaagtgc gaccgacgct ctgggcttta ttatgacccg 2591281 cgaacaggga aaagttacgg tttgcgctta aatttatttt ttaacgtttc taaaagatcg 2591341 acaagcatct gaggaaccgg tatgccaaga gagctggctg tcacaacaat ttgcacagat 2591401 tcataaagaa tataaaacat aatagccaag tcacgaattg atccctgtgt attcagcagc 2591461 tgatcaaaaa agtggcatac agagatcaga gccagcgtga ctaatttttt gacaagccgg 2591521 gcaaatacct ttttaaatga cagtttgtga ataatggttt ccttcaaagt cgtactgata 2591581 aattcaattg ccataagaga gagcaaaatc agaaatgaat actgaaaacc tccaaagaaa 2591641 aaacccgctg ctgaaacgct gactgctaaa aacgaaaaga tgccaaagtc tctatccatt 2591701 tatcccaaca tcctttcaca gaaacggcct tacgatattc tatggtaaac aagccgaacg 2591761 gattggattt ttcagaaaaa tggactggtt gtcgcctatt tttcagatac aaaaagaaaa 2591821 gccggacgtc ttttttaaga catccggccg ttctattttt gaacttaacc taggtaagct 2591881 tttagcatcc agttatgttt ttcaatattt tgatggatcg caagaagcat gtcccctgtt 2591941 gtttcgtcac cgacttcatc agctaaatcc atgccgtttt tcagctcttc cgcgatgact 2592001 gtgaaatcat catatacgct ttgaaccatt tgttcagctg tttcatttcc agcagcttct 2592061 ttgacagaag ccgtttctaa ggattccttc attgttgcaa tcggttttcc gttcagcgcc 2592121 aaaagacgtt ctgctaagtc atcaatataa gttgctgttt cgttgtacag ctcctcaaac 2592181 ttttcatgaa gagtgaagaa atctttccct ttcacatacc agtgataatt atgtagtttc 2592241 acatacatga ccgtccagtt ggctacttgt ttgttcactg cttgaatcaa ttgttctgac 2592301 atggtatctc ctccttgtta tatgactatg tataccctta atatcgtacg ctaaaacctc 2592361 ttttttaccc ttatctgtca cgatttcttc tattatgcta caattgttaa aaaacgggag 2592421 gtggaatgtc atgacgcttc tcattacgat aagtattttg attgtgctgg ctgttttgct 2592481 tgtaaccatt tggacgactg taaaagccta taatgtaaag cataccattg atccaccaca 2592541 agaaaatcac tctgattcac acaatcaatg atgatgtgaa tgctcctctt ctgactgatt 2592601 gctggcagca tcggcgtctc cgacttggac ttttaaggtc ggcatgctat gctgtttttt 2592661 tgctgtgaca tgagattgga cagtgtatac accatcttcc ttaaacgtcg tttccaatcg 2592721 gtatacgcct ttttcttgtt tcaccttaaa catttggctt gcgtcttttt ccccttcttt 2592781 ccatacttca aactctactt catcggcatc cgtcacagct tcatcaccat atgatacagc 2592841 tgcttcataa gcagcgcttt ctccgggatt tactttttca ggcccggtca gcttgacatc 2592901 caaaacctcg ggcgtctcag ctgtatttgc tttactttca ccagatccgc atccattaag 2592961 caataaagca gaaaaaagca gaacaaccaa catctttttc atgccatcac cctttcatcg 2593021 tttacctaaa tagtagcaaa cgcttacagc aaatggtaca caaaatatga gacgtcacaa 2593081 aaaagacctt tttgcttaag cgcaaaaagg tcctttctat tttagccaaa tacttttagc 2593141 aattcttctt tatcctgtga aagccagaaa cgcattaaac gtttagcgcc ttccagatca 2593201 tgaagcttcg cttggccgca ctgcttttca ttcgcagcag gtatttctgt aatctctacc 2593261 gcttccttca ttgtgtcttc aagcagatca acgatttccg ctgatgtcgg ctctccgctc 2593321 acaactagat aatagcctgt ctggcagccc attggagaaa tatcaatgat atcaaaatga 2593381 tcgtatttct cagcgtgaga acgaatcgta aacgcgagca aatgctcgag tgtgtgaatg 2593441 gtgtcaggct tcatcgcctg tttatttggc tggcaaaaac gaatgtcaaa tttatttaca 2593501 acgccgtctg ttcccacttt atgcacgccg caatgtctta catatggagc aacaaccgca 2593561 ttatgatcaa gctcaaaact ttctactgaa ggcataatgg cactctcccc ttttttaaaa 2593621 atgtaatttc attataacat acttttccga taagaattat tgattaactt ttcaatctgt 2593681 gttttttttc ttatacttgc atcagaaagg ttgctgaaga aacatgaaaa ccctattcat 2593741 cgctctgatc agaggatatc aaaaattcat ctcgcccctg acaccgccaa cgtgccgctt 2593801 ttatccgacc tgttcccaat atggaatcga agcgattaaa acacatggcg ctttaaaagg 2593861 cggatggctg acaatcaaac ggattttgaa atgccacccg ttccatccgg gaggagtcga 2593921 tcccgttcct gaaaagaaac aaaaacatta attgttataa ccgtttacga taagatccag 2593981 ttttccggtt ttaggatcaa tgactaagcc atggaccgga acgttttcag ggaacagcgg 2594041 gtgatgttta ataacatcta cgctgtcttt cacactcgct tccactgaat caaagctttt 2594101 aaaccattga tcaaagtcta caccggagta ctttattgtt tcgatgcgtt cttccggaat 2594161 ccctcttgct ttgatttttt caagcatgct tttgctgctg attttgctca tgccgcaatc 2594221 gtgatgcccg atcacacaca cctcatctgc attcagctcg tacactgcga cgagtatact 2594281 tctcatgatg cttccgaatg ggtgtgtcac aagcgcaccg gcacttttaa tgattttcac 2594341 atcaccgttt cgcaaattca tcgcatgcgg cagcagttca accagacgag tatccatgca 2594401 agaaagaatc gccatttttt tatctggaaa ttttgatgtt tgatactttt catactctct 2594461 ttgttcagta aatgtcttgt taaattcgag aatatcattt agaagactca tgttcgttgt 2594521 ccctttctat tctttttact cttcaatata tcacaaccct tgtttattcg tcataataaa 2594581 aaaagacaaa ccctcaggcc tgccttattt ccccatgtta tagcgttttt tgaactgctc 2594641 aactcgtccg cctttttcat tgaatttctg gcggcctgta taaaacggat gcgtgtcaga 2594701 gcttacctct actttaatga caggatatgt gtttccgtcc tcccactctg ctgtttcatt 2594761 agatgttttc gtagaggtgc ttagaaaacg gtagccgctg ttgacatcct gaaatatcac 2594821 tttgtggttc tttggatgaa ttccttcttt catgggtatc tcctttcaat aaatcgtaat 2594881 aattacgttt tattttataa ccttacaaac gttttgtcaa tcttcttata tccttccctc 2594941 tgtttcacat cgtaaacctc atggcattta agaataggaa gaataatcta accgaggaag 2595001 caaataataa acccaaaata catacagaac gtctttttgg aaaggtggtt tacgattgtg 2595061 gatgatttag ttttggccag aagccttttt ggcacgacga tgggctttca tatcattttc 2595121 gcaacacttg gagtcggtct gccgctcatg attttagtgg cggaattgat ctatcaaaaa 2595181 acgaaagatg accattatgc gatcatggcg aaaagatgga cgaaagcaca agccgttttg 2595241 ctgggggtcg ccataccgac cggaacgatc gcgggcactc agctcgcgct tttatggccg 2595301 ggatttatgg aagtcatcgg ccgggtgatg tccctgccat ttcaaattga aatctatgct 2595361 ttttttgttg aagccctatt catgtcgatt tatgtatacg ctgcagaccg tttgtcacct 2595421 gcaatgagga ttgttgctgt tttctttgtg ttagtcgggg cagcagcatc cgctgttctg 2595481 atcacgaatg ttcacgcttt tgaaggtacg cccgccggtt ttaaaatttt aaacggaaaa 2595541 attacagatg ttgacccgtg ggctgcgttt tttaatccta gcttttttat cactgccggc 2595601 catgtcgtgc tgtccgcgtt tatgactggt gcgtttatcg tggcttctgt tgcggcgtat 2595661 aaaatgatcc gaacgaggaa aaaggaaagg gtctatcgct ttcaccggaa agcccttttg 2595721 ctcgcactga cgatcggcgg tattttttca ttgctgaccg ctttgaacgg acacgaatct 2595781 gcacagatgc tgtacgaata ccagcccgaa aaattagccg gtgcggaagg cctatttgaa 2595841 acaagatccc acgccccgct cgctatcggc ggttttaccg acccgaatga agaaaaagta 2595901 aaatgggcaa tcgagattcc atgggcttta agctttttgg cagcgaaccg ttttgacact 2595961 gttgtaaaag gattaaatgc atttccgaga gatgaatggc cgccgctttt cattcacacg 2596021 ctgtttaatg cgatggttgg tgtaggcatg ctgctaattc tttattccat tatcggtgtg 2596081 gtctggagaa aggtgctcaa gaaagaccgt ttcccaacgt ggcttttgat cattttcatg 2596141 acagcaggcc cttttagtct catcggcatt gaattcggct ggattttcgc atgtacgggg 2596201 aggcagcctt gggtcatcta tcatctgctg aaaacgtcag atgtcgtaac aacgactggc 2596261 tcgatcgggg tgctgttctt atttttcaca tttgtttatg ccgtgttagg cgcagctgtc 2596321 gtctacgtgc tgctgtatta tttccgcaag cacccggttg acgaagattt aaatacagcg 2596381 gagtcgtaat ggctccgcaa acaggaaacc aaatggaagg aagatcgtac aaatggagat 2596441 ttcaactgac gctctgatcg ccatctcaat tatctggggc tttgtgttta tttacgccgt 2596501 catggcgaca atggattttg gagcgggatt ttggtctatg atctatttaa acaaggagca 2596561 tatgaaggcc accgatattg cgaatcgctt tttgtccccg acttgggagg tcacaaacgt 2596621 ctttattgtg gccatcgtcg tggcgctttt cagttttttc cccggcgcga catttgtgct 2596681 cggcaccgtt ttattaattc ccggaagcat gattttgctg cttttagcaa ttcgaagcgg 2596741 atttctcgtg ttttcaaata cagcaaagga gcggaaaacg ctaagatata tttccggcat 2596801 ctccggcttt atcattcctg ctattttaat tttggtgctt cctgtgacac acggagggtt 2596861 tatagaaaaa acggatggaa tctataactt aaatatgtct aaaatctttt caagccccaa 2596921 cgcctattca tttatcgggt ttgcgatttt aagcacctta tttttgtcct cgctgttgct 2596981 tgcagatttt tcaaatgtgg cagaggaaca ggatgcgtac cgagcctaca gaaaaagcgc 2597041 cctgattacc ggcccgattt cactgttgtt tgctgtatgc attatggtaa ctatgcggaa 2597101 tgaagcaaac tggctgtaca gcggaatgat gaatgatttt tcttggatta ttgcatcgtt 2597161 cattacattt gtcattgctg gaatcgctct ttttctgcct aacaaaagct ttggtcaaaa 2597221 catcggaaaa ccgcgtctcg cacttgttgc gattgggata cagtattttc tcgcaagcta 2597281 cgcgtacggg cgggcgcatc ttccgtatat gatttatccc gatgtgacag tcatgtcagg 2597341 cttcacagag ccagcaacgt tcagagcgct gtttgcaacg tatatcgttg catttatcat 2597401 tctatttccg ggcttctttt tcttctggaa aatgtttatg cgagataaac gctatatccg 2597461 ccaggaggaa tagagggcaa gccagccggc tatactaatc cagaaccttt ataaggaggg 2597521 gatggcatgg agcagaaaat tctatgtgag gtcaacaact gttcttattg gggcaaaggt 2597581 aacaaatgca ccgctgatgc catttatgtt gtcagccata ctggtgaaac ggctgaaaac 2597641 agccgggaaa cagactgcaa aacgtttaag ccgcatgatt tataattaaa agaaagagct 2597701 gcatcagcca gctctttctt tttgcatgtt gagtgttctc agctttttag ttatgacccc 2597761 gtttgcaggt gaaaacaaaa aggcgcttgc ataacataca cctgtcatgg ccgccatcgc 2597821 tcctgaaatc gaaacattaa gccacgttgc gaagaaatag cccatgaccg ccgacagccc 2597881 gccaatcaac gcgctgagaa tcagcatata aagaagccgg tctgtcagca aatgtgccgc 2597941 agccggcgga acaatcagca tggccacaac caatacggca cccaccgaat caaaggaagc 2598001 aacagtcgtc aaggacagca tgcccatttg cacgtaatga atgagcaaaa ccggtattcc 2598061 caaggctaaa gccatttgag gatcaaacga agcgatttta aactccttat agcacacact 2598121 gatcaacact acgtttaaaa ccagaacaga tgccagcatc caaaacgctt tcggcccaat 2598181 atcaaccccg aataccgtca ccgtattcca cggcacaaaa gcgatttctc ccattaacga 2598241 gtgctcaata tcgagatgga cattcgctcc atacacagaa agcaaaataa ccccgattgc 2598301 aaataaggat gtaaacacaa ctcctatggc agcatctgat tgaaccccct tgctatgaag 2598361 aagctgaacc aagaaagccg ttaacagacc ggttgcggct gcgccaataa acatataaat 2598421 cccatcgaga cttcccgtca ctagaaaagc gccgacaatg ccaagcaaca ctgtgtgact 2598481 gattgcgtcg gccagcatcg ccatgcttct cagcacaaga aatgtgccga tcaatccgca 2598541 gcttacaccg actaatacac cggtagctat aatccatgct tcaaaactca tttgcgatct 2598601 gtcccttctc ggcatcatga gacgcttttc gacgctcagg catccgtcca tacagcttta 2598661 agagtgaata aagccgctct ctcgtttctc tcggtaaacg gtccgggtca aagtagtcct 2598721 gatcggattc tatattggca agttccattt catgcatgag atacacttca tacatccgct 2598781 gcttcaaagc tgtgtgatag cctttttcta tccctttgct tgtgatttgc caaatcccat 2598841 tttcgatacg ctcaatgcac ctctcttgtt ccaagtcatt taatgcctta aggcataatg 2598901 aaggggatag gcgtcttttc tttcttacac tttcaacagt tacacaaaga ttattctttt 2598961 catactgttc ataaatcgcc aaaagcactt gctccctgct tgttctgcgc cgcagcctca 2599021 tcagccttat ggctttagca gccaatcccc gcttaggcgc gcaaatcatt gaaaaaagaa 2599081 agagcagcgt tgcagataag atcattaatg gccctgtcgc cattcccttc atcgtggtgc 2599141 taagcagggt tccggccact ccgctgaccc cgcctgtaat cccggcaatg atgatcatcc 2599201 cggttaatcg ttcggtccaa tatctcgcgg ttatggcagg tgtaatcagc atagccgcca 2599261 ttaatatcac accaacagtc tgaagcccaa tgacgacagc acagacaatc agacaagcca 2599321 aaagcccgtt taaaaaacgc accgggattc ctaatccctt tgcaaacgcg agatcaaaag 2599381 taatcaatgt aaattcctta aagaaaacaa tacataggag cagtagaaca gcggatatcc 2599441 ctgcaataag gatgatatcc tgcctgacca atgaagcagc ctggccgaat aaaaaagaat 2599501 caagcccgct ttggcttccc gccccctgtt gctgaatata tgtcagcaga atgatcccga 2599561 cgccaaaaaa cacagaaaga acaatcccga tcgccgagtc ctcctttgtt tttgaaagcc 2599621 gaggaatcag ctgaatacaa aacgttccga gcagtccggc gagcgctgcc cccagcaaaa 2599681 agaaaggcag tgatttttgc ccggtgaaca gaaaagcgag acacactccc ggcagagctg 2599741 aatgggccat cgcatcgccg attaaacttt gctttctcag cagcacaaag ctgcccaaaa 2599801 caccgcttgc cgtcccgagc aaaagcgtac cggccagcac ccactgtgta ttcggatgct 2599861 gaagctgcag ccacaaactt tcaaacattg cgctcactcc ttatgtcctt ctgccagcac 2599921 tttatctttt aaaaacgtaa gccttcctcc atatgttttt tgcaggtttt cgatcgtaaa 2599981 aacgttttcc gtcggtccga aagcgatttt ccttaaatga agcagtaaga tccaatcgaa 2600041 ataatcctcg gcggtctgca gatcatgatg gacgacaagc acggtttttc ctttttcttt 2600101 gagttctgcc aacagcgtca taatcgcgcg ctccgtcgct gcatcaacac ctgcaaacgg 2600161 ttcatccata aaataaatgt cagcgttctg gcagagtgcc cgggcaagaa acacccgctg 2600221 ctgctgtccg cctgacagct ggctgatttg ccttttcgca taatcatgca tcccgacttt 2600281 tgttaatgcg gccttcgcca tctccacatc cgctttcttt ggcctcttta ataaaccgat 2600341 tctcccgtat cttcccatta ggacgacatc gagcgggctt gtggggaaat cccagtcaac 2600401 cgagccgcgc tgcggaacat atccgattct ggtccgctga tccttatagt ctttgccgta 2600461 aatagagatg tctccggaag ctctgggcac aagaccgaga atcgttttga tcaaggttga 2600521 ttttcccgcg ccgtttgggc cgataatgcc aataagtttt ccttcaggca cctgcagcga 2600581 aatgtcctgc agtacaggct ttttatgata agcaaccgtc acattatcaa gctcaacagg 2600641 gaacatatcc tccacctctt ttctttattt aagcgcttta gtaatcgtgt tgatattgtg 2600701 gcggaacatt ccttcgtatg tgccttcttt tgtgcccttt tcacccatgg catccgaata 2600761 aagctgaccg ccgattgtga ctgtatggcc tttttcttta gcgccttcca ccactgcatt 2600821 gattgatttt tcagatacac tgctttctac gaacacagct tttatttgtt tttctgtcag 2600881 aagatcaacc agctcctgaa catcccttaa tccatagtcc gaatctgtgc tgagtccctg 2600941 caggcctttt accttaaatc catactcatt cccaaagtac gcaaacgcat catgagcagt 2601001 cacaagcaca cggcttttct ccggaatatg tgcgatctcc ttacgcgacc acttatctaa 2601061 atattgcaaa tcttctttgt actctttggc atttttccga aaggcatctg cgtgctgagg 2601121 cattgctttg ctgaattgcg cttcaatttc atccaccgca tagatccata acggaatgct 2601181 gaaccagacg tggggatcaa acgtcttgcc ttcccccgcg ggaataagct tatttttcgg 2601241 aatggcctca gctactgccg ccgattgttt ttgttcgccg attttttgga ggacatcctc 2601301 cattttccct tccaaatgca acccgctgta cagaacaaca tcggcagaca ttaatttttt 2601361 cgtgtcacct tgggaagctt tgtaaaggtg cggatcaacc cccggtccca ttaaagaggt 2601421 gacttttacg tgcttacctc cgatgttttc tgctgcatcg gcaatttgag atgttgtcgc 2601481 tgtcacttgt aattgctgat cagcgctttt tccggctgaa tccgttccgc atcccgttaa 2601541 agcaaaggtc gcaaaaagta ctgctgccat cagcccttgt ctcatatttc tcctcctctt 2601601 tgccatcaat gtccgattgt tttatcttat gttgtcagtt cttagacatg tgacattaaa 2601661 ttagccaaaa gcatgtttta tttacacagg acaaaaagtt tccctcatgc aaaattatcg 2601721 cgtttggcca tttttgtcaa gctgatttac ataaaaaaac cggctgggtc agcagccggt 2601781 ccaaacgaga agggatgtat tcaacgaaca cttttactgt aacagcacag tgtcatttat 2601841 tcaaaatagc aaaatgcttt tttcttaacc atgctgtgtg aaaacatcca ttttggtcac 2601901 atattttcgc ataatatctt ggtttacctc aacccctaaa ccaggctgtt ttgacacaga 2601961 aataaatcca ttatcaatac gaatatcagg agttacaata tcttcatccc aatagcgtga 2602021 ggatgaagat atatcgccag gtattgtgaa ttgaggcagt gaagcaagcg ccacgttctg 2602081 cgctcttgat atgcctgttt ccagcattcc tccgcaccaa acctgcatat gatgctcttt 2602141 gcataaatca tgaattttta aggcttctgt taagccgccg acacgagaag gttttatatt 2602201 aataattttg cagcttccta gctcaatcgc ccgtctcgca tcatcaactg aacaaatgct 2602261 ctcatcaagg caaatggccg ttttcaaatg tttctgcaag tggcggtggt caacgatatc 2602321 gtcagcttgg agcggctgct caatcatcat taaatgatag tcatcaagct cctttaaacg 2602381 gctgatatcc ttcagttcgt aagaggaatt ggcatcggcc ataagcggga tggttgggaa 2602441 tcggctgcgg atggccttga ccaattccac atcctgccca ggctgaattt taatttttat 2602501 tctttgataa ccttcttttt gatagctctc aatttccttc agcatatcgt caagaggcgc 2602561 caggccgact accaccccgg cagggacttt atctcttgtt ccgcccaatg cctcagcaag 2602621 ggatacgccc ttctttttgg cataaatatc ccatacagcc gattcaagtc ccgcttttgc 2602681 catccggttt cctttatacc gcgccaggct gtccggcact tctgaagggt gattgaattc 2602741 acggccgacg acatttggga taaaaaaatc ttttagcata tgcaaacatg ttccaatggt 2602801 ttcctcggtg taccaaggcg aagagaaagc ggaaacttct ccccagcctg tgacacctga 2602861 tgtatcaatg gcttccacga tcagaaattt acgctcttga agcgtttcga tactgttttt 2602921 aaacggtttc tttaagttca tgctcaaatg gtaaagcgtg attttttcta tttcgatcat 2602981 agcagttctc ctttacgcgc atccttcagc tgatttcgca agagcttatt agacgcattg 2603041 cgcggcaggc ggtcaagcac aaagaatttt gccggaattt tatacttcgc caagcgttct 2603101 ttgcagtagt cagtcaattc tcctgcgctc acaggcttgt gaaggacaag ataggcgtga 2603161 ggcactttcc cccatttttt gtcctcagcc cctgaaaccc cggcttcggc cacagcgggg 2603221 tgtgaaagca gcactgactc cacttcggcc ggataaatgt tttctccgcc ggatatgatc 2603281 agatctgaac gtctgtctaa tacatataaa aagccttcat tgtccaaata accaagatca 2603341 cctgttttca gccagccatt ttgaaaggag gcttcgtttg cgctctcccg gttaaaatag 2603401 cttttcatga cattcgggcc tttgaccatg atttcaccgt gttcatacgg ttcacatacc 2603461 tgtccgtccc gctctatttt gatttcacac gaaaacagcg gtttccccgc agatccgagc 2603521 ttttccatgc tgaattccgg cgacagggta acaatttgcg agcatgtttc tgtcattcca 2603581 tatgactgaa agacagggaa tcctttctca cggcattcct caagcaatgg cagcggtgca 2603641 ggaccgccgc cgagaagaat gcatctgatg gattcagggc agcggtttgt ttcttccaaa 2603701 agactggcca gcatagtctg caccgcagat atcattgtca cttcatgcct gttgatagaa 2603761 tgcagcacat cgcttacgga aaaacgctgg tgaagcacga cagtcattcc atagatcaca 2603821 gatttaaata atgcggacaa tccgctgata tgaaagagcg gcaatgcgat aagccagcgg 2603881 tcttgttctg ttatacccaa attaagagcg gacgacaccg cactgaaata atggtttccg 2603941 aacgtttgct gaactccctt gggctttcct gtcgtacccg acgtatacat cagcgttgcc 2604001 gttgcatcca tttgcatata agcctcgatc tcaatttcct ctgctgcttc tttcatcagt 2604061 tcatccacat caatcgtttg aacgatgtgt tcatattctt tcttctcaaa gcttgaatct 2604121 gtcaataaaa agccggatcc cgaatcctcc agctgaaaca gcctttcatg tgttgacagc 2604181 ttcgtattca aaagcaccgc cttaacacca agcaaaaaac aagcgtgaac agcgtatacc 2604241 atttctgcac ggttttggag caaaatagct gcagtatccc ctttccgaac cgaatgagcg 2604301 gcaagctgtt ccgccattcg tttagacgcg gcaaacaatt ctgcaaatgt cacggtttgg 2604361 tcttcataga tgagagcgat tctctcaggt gtcagctgtg cccgctgcat gagccagttg 2604421 ggctgttctg tcagcatgtc atcatctccg aggtaaaatg tctgtattga aaagaaaaca 2604481 gcttggaccg caaagtctca agctgttggt ttactagata ttgctgatca cggaaaacga 2604541 gggaactgtc cgaaatcagg tttgcgtttt tccttaaagg aatcacggcc ttcttttgct 2604601 tcatctgttg tgtagtaaag aagggtagca tcccctgcaa actgctgaat tccagcaagt 2604661 ccgtctgtgt ccgcgttaaa cgcagcttta agaaagcgca gtgcggtcgg gcttttttca 2604721 agcatttctt cacaccattt aatcgtttct tcttcaagct gttccaaagg aacgactgtg 2604781 ttgacaagac ccatgtccag tgcttcctgt gcgttgtact gacggcatag gtaccagatt 2604841 tcacgtgctt ttttatgtcc tacaattcga gccaggtagc cagaaccgta acctgcatcg 2604901 aagcttccca ctttagggcc tgtttgtcca aaaattgcgt tgtccgcagc aattgtcaag 2604961 tcacatacga tgtgaagcac atggcctccg ccgatcgcat atccggacac catcgcaaca 2605021 accggtttcg ggatgacgcg gattaaacgc tgaagatcca atacgttaag acgagggatc 2605081 tggtcgtctc ctacatatcc accgtggccg cgcacttttt ggtctccgcc agaacaaaat 2605141 gctttgtccc ctgcaccggc aagcacgata accccaacgt tttggtcgtc tcttgcgtca 2605201 gcaaacgcat caatcatttc agcaaccgtt ttaggggtaa acgcattatg tacctcaggt 2605261 cggttgattg ttatttttgc aatgccatta tacgtttcat acaatatctc atcgtatgtc 2605321 cgttttgttt tccattcagc catatgatga cctcctttta ttctctatgt gaatgagtca 2605381 gatgcttgtc aaaaactcac tcactatttt accaaacaat cgcggctgct ccacatggac 2605441 cgtatgtcct gcttttggaa caatctctat tctactagaa ggaagcatct tatgcacctc 2605501 ttgattgatg gcgcaaaatt tttcgtccca ctccccgcag atcagaagca caggaacatc 2605561 tatttcctct acacggctcc acaaggaagg ctgtgaaccg gtgcccatgc cggttaaact 2605621 gttcgcaagc ccaatcttat tgttccgcag acggcccgat cgtatcctgt accgaatatc 2605681 ttcagccagc ctctgctgag atgaaaacaa agggatattc tcccaatacg caacaaacgc 2605741 ttcgagcccg tctcgtaaaa taaaatcagc aagcttccgg tcccgcatga ttcgttcccg 2605801 ccgttcccca agtgttttga gccccggcgt cgtgctttca agcacaagtg ccgatacccg 2605861 ctcgggatat gtcatcgcaa aagagtaagc aagccttcct cccatagaat acccaatcaa 2605921 tttcactttg tgaagtttta attgatcaaa aatctcggca aggtcagaaa cttgccgggt 2605981 tgtgctgtat cttttcccat tcagcggggc atcggtttcc ccatgcccta aacaatcaat 2606041 tttgatcaaa cgggaatcag gcagcatttc atcaagaaaa gtccatgatt gtttgctgcc 2606101 ggtaaaccca tgcagacaga cgacggcttc ggaagcattc ggtccctcgt ctgccactgc 2606161 atatcggaca ccatctgata ccgttatgtt tacagttccc attgtttttt cacttcccgc 2606221 acagcctcat tcagcatatc gcgatgaagc tggactcttg attggcgatc cgttttgatt 2606281 tcaatcaaat ggagtccggg cttgtctgcc tgcggcgcgt aagctgtttt gaattcatcc 2606341 caagaagccg ggcatgaata cgttccgccg taaagtgcag ccgcatgctt gaaatcgagc 2606401 cctgtcggtg tgccgaacaa atcttcaaag tgtgtcttct cagaagcctg cggcaaaaag 2606461 gagaaaatcc ctcctccgtc attattgaca agaatcacag taagaggaat acccagcttt 2606521 ttggccgcca gcaggccgtt taaatcatga taaaaagata aatctccaat cacaagggta 2606581 acaggcgctt ttgttccttc acataccccc atggcagagg agacgacacc gtctatcccg 2606641 tttgctcccc ggtttgaata aatccggaaa gggcggtcct gcttttcaaa aaacgtatca 2606701 acatccctga tcggcatgct gtttcccaca aacagcgagc tgttttcagg cacaagatgc 2606761 tgaaggattc gatagagatt gccttcaaac gaaacatctt cactgctgat tgtttgcaga 2606821 tgctcgcgga accgcccatt gacaaactgc cacttttcca gccactctga ggatctggtg 2606881 gcagcagtaa ggcctgccat gatctcctca gcaaaaacag acgcattaca atgaatcata 2606941 tgcgcgcttg cctgtgtcgg gtctctccac cctccatcct cgtcaatcac gatttgctga 2607001 atcgtcggat catccttaag ccataagaaa accggttttg aaacaggcat cggtccaaac 2607061 cgaatgacaa catcaggacg gagtttccgc ttcagctcat catcttttaa aaacgaatca 2607121 tacgcatcaa taacagtgct tttatcatga acaccattcc gcagattaga cagcggatct 2607181 gctaaaattg gatactgaag cgcttttgac agcgcaataa tgttttcctt gtccgcatca 2607241 ctatggagct ctccgcagac gatcattcct ttttcagcct ctgcgagcat ctcagccaca 2607301 tcagacaggg actctcggtc aacagactgc gtacccgttt tcacagacac atgacggcct 2607361 gttctcattc ttccaaacgg ctcatctgaa agatccggca tcagcggttc gcgcagcggc 2607421 acattcacat ggacaggccc catcgggcgc ttttgtgctt ctccggcagc gcggcttgcc 2607481 agcgttcgga tgtatctcag catttgcgga gactcttcag gaagagcaga gtctgtgaaa 2607541 aacttaacaa agttaccgaa taagaagtgc tgattaatag cctgcggtgc gcctacttcg 2607601 cgcagctcat gaggccgatc agcagttaac acaataatag gcacccttga ataatgggct 2607661 tcaaccacag ccggataaaa gttggccgcg gctgttccag atgtacagat caatagtacg 2607721 ggacgctgct tcgcttttgc caaacctaat gcaaaaaatc cggcagacct ttcatcaatt 2607781 tggacatgga cgctgatatc gggatgcgca gcacaaagaa cagccagcgg tgtagatctt 2607841 gagcccggac aaacgacggc gtccgtaatt ccggaaaggg cgaattcatc aataaaactt 2607901 ccgatgtaat gagtaatcgg gttgactgtc aacgcctctc acctcctaat gcagagatca 2607961 tcggcttcaa tttaatctgt gtttcttcat attccgagat tggttccgag tcttccacaa 2608021 taccgcaccc ggcaaacagc cttgctgtgc ttccttcgat gagccctgaa cgaatggcga 2608081 ccgcgaattc cccgttatcc tggctgtcaa tccagccgat aggggccgca taccagccgc 2608141 gggacatcgg ttcaatctcc ctgatcacgt caacagcttt ttcctgaggt gatcccccaa 2608201 gcgcgggagt ggggtgcagc ttctcaatta agtcaaaaat cgaagcagac tcgcgcagct 2608261 gtccgacaat cggcgtaaac aggtgctgaa cgctttttgt tttgtacaaa acaggtccat 2608321 caggcttttc aacctctgaa cagcttgata caaaagcatt atgaatcata cctaccacaa 2608381 tatcatgctc aagcaggttt ttctcatcgt ttaataattc aaggcctatc cggcggtcgt 2608441 cttcttcatt cacgcctcgt ttaatggagc ctgccagaca ggaagacatg acagtgccgc 2608501 cgtctctttt gatcagtctt tccggagacg cgccgacaaa ggttttgcct tcttgttcaa 2608561 ttgcaaaaac atagcttgtc tgctgatcgt ccagaagcgt tttaagcacc ggttcaattt 2608621 ggattggacc gtcaaacgtg agcagcagct ctcgggcaag aacaacctta tcatattgtt 2608681 tctctttaat ttggcttgtg gccgtttcga ttgctttcag ccaatcatcc ttatccagct 2608741 cttcggctgc tgcaatcaca gcctgatctt cttgcttgaa atcgggaacc ataaattccg 2608801 ccgcaaaagc ttttaagcct tctaaaacag cttctgcgtc ttctcctccg cttacccatc 2608861 tgttaactgt taagaacggg ccttcagcag tcatcgtcag cataagcgca ggcacaaaga 2608921 aatccccttc cgagaaatgg tcccattgtg aacctctttc ttcgcaaggg tcaaaagaaa 2608981 atcctccgaa taacacaggt cccactgcag aatgctgcag cttttcttct tcataaatat 2609041 gaaaagccgt ctttttaaag cgctcccatt gttcaaaaac ctcacgatac cgctcgctgt 2609101 ttttttgatt tgtctggaaa accgcttctt tgccaagacc gactattgtc aattcacttt 2609161 caggatctga ccaaaaaaat cgattgcctg tatatttttt tgctccgtaa ttgaaaaatg 2609221 atagagggtc aagagactcg atttgtctcg aatagcttat taagacagca tggttgactt 2609281 ctttggcttt atgtaatgca tgtagaactt cctttcggaa cgtacgctgc accgttgtca 2609341 ccatgagaca ttcctccata atccttaaaa tgcttttaat accatacacc tgtgtctcct 2609401 ttgtgtcaaa cacagatcat gcagtccaaa tggcctgcct tacctattat aaacctaatt 2609461 tcagaaatga aaaagaaaca aagcttaaat ttctttctcc actgatagca aaggttgtat 2609521 ccgcttacca taaaaggaaa acctcctata ttcctccacc cgccatttat gaaagttctc 2609581 aggcgatctg ttcatactaa aggtatgcat cacagagaaa cgaggcgatc acattgctta 2609641 cgaaagaaca gcttcagcat ttaaaaaatg aactggaaca aacgaaaaaa gatatcttaa 2609701 accgtttcaa agacaatgat cattttcagc ttaactcagc ctttccttat gattcgtggg 2609761 gtgagctttc ggcatacgac aaccatcccg gcgatcaggc gacagaactt tacgagcgtg 2609821 agaaagacat cgctctagac ttgcatgaga gagagcacct tcgggacatt gagcattcat 2609881 tgaaggcgat agaaaacggt acgtatggca tttgtgaagt cagcggaaag gaaatccctt 2609941 tcgaacgact tgaagcgctt ccgactgcca caaccctcgc ggagtattcg tcacaggacg 2610001 tggtttccaa agaccgtccg attgaagaag aaacaccatt cgggcaattt gaatttgatg 2610061 atgatgaaga aatcagagcg ccatatgaca gtgaggattc ctatcaggat gtcgaaaaat 2610121 atgggaactc acaaacgccg caggatatgg aaaaccctcc gctcagctat gatgatatga 2610181 cgatgaatgc cgaagagaat atcggcaata cggagtctta cgaaaatttc atcgctacag 2610241 atatcactgg gaaagaaatt accgtttatc aaagcagagc ccatgagcgc tatgaagaag 2610301 aacttgacga agagggaatc atgaccacat tcggcgatct ccacgctgat tgaaccccca 2610361 attattgggg gttcttttcc gttttcagca tatcgtaaat cagcttcaga taatcctttt 2610421 gcaggccgat gtcataccgc tcgccctcta gcaatttccc gtatacggta catgccccga 2610481 gcgaagcttt tatcgcatcc gttacctgca cttctcctcc gctatcagct tctaatgcct 2610541 ccagctcatt aaaaatatcc ggtgtgaaaa tataacgccc tgctgcggca aaatgagacg 2610601 gagggttttg tttaggcttt tccacaatat cctgtatgcg ataaagccct ttttcaacag 2610661 gctccccttt tatcaccccg taatgatgta aatcctccgt ttttgtttct tttaagccga 2610721 tcacactgga ctgatatttc gtatacgctt caatcagctg ccccaaagcc ggctgattgg 2610781 cggaaaaaat cagatcatct ggcaaaacga cggcaaaagg ctctcctcct gcaaattgct 2610841 ttccgaaaga aatggcgtcg ccaagaccct ttgcataagg ctgccgcaca tagtgaatcc 2610901 gtatatccgg aatgggatgc tctctaagta aatgcagttt attcttagag gccaaaaaag 2610961 cctcaagtgc caaagaggaa tcaaaatagt cgacaatcag atttttatgg ctcgatacaa 2611021 ccatcaaaat gtcctcaatg cctgactcct ttaattcttc aacaagataa tgaatcacag 2611081 gcttagatcc taccggaaac atttctttcg gaatcacctt cgtcaccggc agatttctcg 2611141 tgccgaatcc gcctgcagga atgatcgctt tttttatcat ggtattttcc cctcagctca 2611201 tgtttattac atgatattcc aagagcgcat cccgatgttt gtacatctga aattaggcgg 2611261 aagcaactgg gcagaaagcg gaatcacgaa ccagcccttt tttaatagga tattgatata 2611321 tgaccagtaa tcttgtaaag gagctcaggt gatgaaaatt tgtgtggttg gcgccgggta 2611381 tgtcggttta accctatcag cggcactggc atccatcgga catgacatga tatgcacaga 2611441 caaagacgtc aaaaaaatcg ggcagctgaa aaaaggagtc attccctttt acgagcctgg 2611501 gctttcagat gcaatacttc gttgcggcaa tctctcgttt tcttctgaag tgaaatcgag 2611561 catggaggaa tgtcccgtta tttttatcgc agtcggaact ccgccgcgtt cggacggatc 2611621 agctgatacg aaagccctgc agtccgtcat cggtgattta agcgaggcga tccgatcgta 2611681 taaaaccatt attacgaaaa gcactgttcc gcccgggaca aatgaaaaca tagcaaaaca 2611741 gctgattgcc tccggagtgt ctaaaaacct ctttaatatc gtatccaatc cggagtttct 2611801 gcgggaaggc aatgccttat atgacatgct gcatcctgac aaaacagtca tcggtgttca 2611861 ggaagaagat cacgtatcgg cagccatcgt caaatccatt tacaaacaca ttgatacccc 2611921 ttttatcgtt acaagcttag cgggagcaga gctgatcaaa tatgccaaca atttcttttt 2611981 agcggccaaa atttcgttca ttaacgaaat ggcccgcata tgtgaagcct atcaatcaga 2612041 tatctcagat atttcccgcg ctatcggtct agacccaagg atcgggaagc actttttgca 2612101 ggcaggcatc ggatacggag gctcttgttt tccaaaggat ctgcaggcgc tgcaatttgc 2612161 tgcccaggaa aaaaacacgg agaccttcct gctccgggcc gtgcagcaca ttaatgacac 2612221 ccagcttggc ctgtatatca aaaaaataca gtcattcttc gaaacacttc aaggcaagaa 2612281 agcggctgta ctcggcattt ccttcaaacc gaatactgat gacatccgga attctcaggc 2612341 tgtcagactg atggaaaggc tggcggagct gggatgtgat gttcatgcat atgatcctga 2612401 agctgtactt ccagaacatt tgcggcaaca tgtaactcag cattctcaag cttttgatgc 2612461 gatcgaagag agtgactttt tatttttggc gacagaatgg tctgagtttt tagcgtttga 2612521 ttggaaaaag gctgcagata tcatgaaagg gcgtcttgtg attgacggac gcaacgtact 2612581 aaaaaaagaa ctgatcgagg cttgcggcct gatctgtacg ggagttggcc gtccatgaaa 2612641 atactcgtca caggagcagc gggctttatc ggctcccacc tctgcgaaga attactaaaa 2612701 gataagaaac ataacgttat cggaatcgat gactttatcg gtcctactcc attttccttg 2612761 aaattaaaaa accttaaaaa cctgctgccg gaaaagcgat ttacgttcat aaaggaaaat 2612821 ctgctgacag ccgatcttgc ttccttactg gaaggagtgg acgtcatctt tcatttggcg 2612881 gccataccgg gtgtccgctc aagctggggc aatcattttc acccatatgc cgcacataat 2612941 atccaagcgc tccaaaggct cctcgaggcg tgccgggaac attctattca aacgttcgtc 2613001 tttgcatcca cctcttccgt ctatggcgaa aaacaaggaa aagtcagcga aaacacgtcg 2613061 ctttctcctt tatctccgta cggggtaaca aagcttacgg gagaaaagct ttgccatgtg 2613121 tataaacaga gctttggcat tccaattgtg attctccgtt tttttaccgt atacgggcca 2613181 agacagcggc cggatatggc ttttcaccgg ctcattaagc agcaccttca gcaaaagccg 2613241 cttaccatct tcggtgatgg gcagcagtca agagatttca cttatatcag cgactgtgtc 2613301 aaaggcatca ccgctgttct tgggaaaccc caccttattg gtgaaacagt aaatatcggc 2613361 ggcgcagagc gtgcctcagt cttaaaagtt gtctccctca ttgaggatat ttccgggaga 2613421 aaagcaacac tgcacttttc ggacaaaata gcaggggaac cgagcaacac gtgggcggat 2613481 atttcaaaag caaaacagct cttgcattat gatcccgcca catccttaaa ggatggcttg 2613541 accaacgaaa tcgcctattt atcgtcgctg tatcaggggg aataaaaatg aagcttgcct 2613601 ttatctgtac agaaaagctg ccggcgcccg cagtacgcgg cggcgctatt caaatgatga 2613661 ttgacggtgt cacgccctat ttcagcagca ggtacgacct gaccattttt tcaatagaag 2613721 atccatcgct cccaaaaaga gaaacaaaag acggcgtaca ttatatccat ctgccaaaag 2613781 aacattaccg cgaggcggta gccgaagagc tgcgagcctc ttcctttgac ctcattcatg 2613841 tgttcaacag gcctttaaat gtctctttat ataaaaaagc ctcaccaaac agcaagatcg 2613901 ttctgagcct gcataacgaa atgttttctg aaaaaaagat gaccttcgcg caaggaaaag 2613961 aagtactcga caatgtctcc atgatcacaa cagtgagcga atttattaaa caaaccgtca 2614021 ttgaacgttt ccctgaagcc gaggacatca caaaagttgt gtattccggc gttgatttaa 2614081 actcttatcc gcccgtctgg acgatgaaag gctcggctgt cagaaaaaca taccggaaaa 2614141 aatacggtat tgaagataaa aaagttattt tattcgccgg ccgcttaagc ccgacaaaag 2614201 ggcctcacct tctcattcac agcatgagac ggattttgca gcagcaccct gatgctgtac 2614261 tggtcatagc aggcgggaag tggttcagcg atgacagcga aaaccaatat gtcacctatc 2614321 tgcgcacgct ggcgctgcca tacagagacc acataatctt tacaaaattc attcccgcag 2614381 acgatatccc aaaccttttt ctgatggcag atgtatttgt gtgcagctct cagtggaacg 2614441 aacccctcgc ccgtgtgaat tatgaagcaa tggcggccgg cacgccctta attaccacaa 2614501 accggggcgg aaacggtgaa gtcgtaaaac acgaagtcac cggccttgtc atcgatagct 2614561 acaacaaacc ttcttcattt gcaaaagcaa ttgacagagc ctttacagat caagaattaa 2614621 tgaacaaaat gacaaaaaac gcccgaaagc atgtagaagc tttatttacc tttacccatg 2614681 ctgccaaaag gctcaatact gtttaccaat ccgttctgac cccgaaaaac aaacaatttc 2614741 cgccgccttt tctgacgcaa aattttgatt tatcatctat caatcagctt tttgtgaaag 2614801 caaaaacata aaacctacag ctcgtgttgc aaaacgggct gttttttcgc tacagagaac 2614861 ttaaaaaaag gcataaatgt gactttatgc cttgcgcttt acagtttgag aaaaccatgg 2614921 agctggttta gattcacttg gaagaatgat gatttccact ttagcttctt ccgctaagtc 2614981 tggttcttca tcttcatcct cttcttcata tgggggcgct gagcgtttcg aatcacgctc 2615041 ctcctcaggc tccagagtgg tttcgaattt tgtttcttct tcatcatcga cgattttgcg 2615101 atctgtttcc ttttccttcg tttctttttg atattctttc ggtgcattga tgtgagggag 2615161 ctctcgaatg ctgcccacat ctaaatgctt ctcctcttct tccttctcag ctgagattga 2615221 gtcatgagcc tgccatccca tcggtccagg cggtgtaaat acgaattggt cgagatccag 2615281 tttagaaata gaggcttttt gtctcgatga cctcatgtca attcgcctcc cgatacgctt 2615341 ttatcttttt atacagttcc ggcagtttat ccaaaaacga atctttagat tcttcaacag 2615401 aaatcatgtt ttgcagcgcc cagttatact tctcatctga ccacgttttc ttttgcttca 2615461 aataatattt gtgcccgatt gcacagaaca aatgcggaaa cgcgagatca atccaaagta 2615521 cctcgtactg tttttctgtg agcggataca ctgcgtcgta ggccgcaagc agtgcaacca 2615581 tgaaatcagt atcccataca gaaagcttaa ccatcacttt attcagcaga atacgaaggt 2615641 ctcttgacgg caaatcgtag gtaatcgagt gaagctcctt taaaaaaggc tccccttcga 2615701 tctcagtcaa acgtgccaat gtaaaatcct gaaaacagaa tccgccatgc tcgagtgtct 2615761 cttttgtcca ggtttcgtat tctgagtcat caagcgctct gagagcttct tttcctcttg 2615821 ccagcatttt atcagcatgt tttaagaaag tttgcgaaaa tacgtcatca ggataggatg 2615881 ctgcgatctg catattccct tcaagttcct gcagcttcca acggtacaat ttgtgccatt 2615941 ttcccagcct gcttctcttc ttgctttcat ctgtgcaaac atatcctttt gaggcatgat 2616001 gaaaatggcc ggcaaatgac atgacttttt tcatttgctc tgcatcatag taaatcattt 2616061 cttttcctgt cactttgtca tataaactgt aagaaacctg atccgtgccc aagcagctac 2616121 cgccattttt tgtttgatga atcggcgcta tcggcagccc tttctcttgt aaatgggcgt 2616181 gtgcctgagt gataaaaagc atccgctccg gtttcatttg cgcttctttt agcagctttg 2616241 ggccatgatc agtttcgact tcccagattt tgcgcccgct tttgttcgat ttcagcgcca 2616301 catggtcgat atgaaacgga taataactga gaatttcgga cacaatctgt tcttcatgct 2616361 ctttttggta cactctgttc accccttcta tctgttcttt tcatagacgc tgagcagatt 2616421 ttcagccacc ctctgccagc caaaattgct ttctgcctca cggcggctgt atttcccaag 2616481 ccgttcccgc ttttccgagc tgctcagcaa atcattgata cgttcggcat attgtttagg 2616541 attttcaaag tcatgaatga tgtagccgtt tttcccttcc tctatgacct ctggattgcc 2616601 tccccgattg cttgtaataa taggaagtcc cgcagccatc gcttcataat gcacccttgc 2616661 taaaggctcc tgccattgcg aagagcatac aaatacatct gacatggtat aaaggcgcgg 2616721 aatgtccttt ggcttcacaa attgaataaa tgtgacatga tccttttgca tcgcaccaag 2616781 ggtatgaaga tgtttgacat agttatttaa ttcattatct ccgaaccatt ttgacccgat 2616841 aaacaccatc atgacatcgg ggtgctcctc aatgatgtcc ggcaaagcct gcaataatat 2616901 gtgcgggcct ttgactttgc taagccggcc gacaaacaag acgatttttt tgccgtgaag 2616961 ccccagctcg cttcgcatct cttcgcgagc tcgctgccct tcattcgtcc agcgagggtg 2617021 gtacgttttt aaatccacac cagaatacac cgtttttgtt tttgatcgtg ctgacggaaa 2617081 acggcttgtg atcgtctgtc cgatataatc gctgaccgta acaatctgcg ctacggagtc 2617141 gatgcaaatc tcgccttccg cctggctgat tttatcgtaa gcgaacattt cattgtgaac 2617201 gcttaaaata aaaacagcat ccggcgcctg tttcttcaat ttcggaaccc agcttgggcg 2617261 attacaaaca tgcacaagat caaaacggct ctttttcagc tctgctccaa cggcttcttc 2617321 ataacggtct tcatccaaat gcacataatg gacaccgtct accttctctc tatcagcgag 2617381 attcggatct ttaatagaaa acacagtcac ctcatgtttt tttgcaatta aaggggcaac 2617441 cgcttcgagg tagatttgaa tggcgcctcc tcgaaccgat gggacaggaa gcttctctgt 2617501 ggcgatcagt gctattttca tacatagcct ccattcctgc atgattttta actagttaga 2617561 atcatgatac ggctgaacaa ccaacttgtg cggaatggga ctgccctaaa aacaaaacgg 2617621 gtaaacaacc agattcatct attaaatata gtcaaataac tcaatcattt tttccttttg 2617681 attcataagg taggagtaaa acaggtaagg atgtgtcctt taatggcaga aaaccatgaa 2617741 gtcattgagg aggggaattc atcagagctt cctttatcag cagaagatgc aaaaaaatta 2617801 acggagctgg ctgaaaatgt gcttcaagga tgggatgtgc aggctgaaaa aatagacgtc 2617861 attcagggaa accagatggc gcttgtctgg aaggtccaca cagactccgg cgcggtttgt 2617921 ctaaaacgaa tacacaggcc agaaaagaaa gcgttgtttt ccattttcgc gcaggactat 2617981 ttagcaaaaa aaggcatgaa tgttcctggc atactcccaa acaaaaaagg cagcctatat 2618041 tctaagcacg gctcatttct atttgtcgta tatgactgga tcgaaggaag accgtttgag 2618101 ctgactgtaa agcaggactt ggagtttatc atgaaaggcc ttgctgattt tcatacagct 2618161 tccgtcggat atcagccgcc aaatggcgtt cccatattta ccaaattagg tcgctggccg 2618221 aatcactaca cgaaacgatg caaacagatg gaaacgtgga agctgatggc ggaggcggaa 2618281 aaagaagatc ctttctcaca gctttatctt caggagatag atggctttat tgaagacggg 2618341 ctgcgcatca aagaccggct tttgcaatcg acctatgttc catggactga acagctgaaa 2618401 aaaagcccta acctttgcca ccaggattac ggaaccggga atacactctt aggagaaaat 2618461 gaacagattt gggtcatcga cttagatacc gtatcatttg atctgcctat tcgcgatttg 2618521 cgcaaaatga ttattccgct tttggatacg acgggtgttt gggatgacga aacatttaat 2618581 gtcatgctga acgcatacga atccagagcc ccattaactg aagaacaaaa acaagtcatg 2618641 tttattgata tgctgtttcc ttacgagctt tacgatgtca ttcgcgaaaa atacgtccgc 2618701 aagtctgctt taccgaagga agaattagaa tcagcttttg aatatgaacg cattaaagca 2618761 aacgcattgc ggcagcttat ttaagaccat catttccccc gcatatcggg ggtttgatat 2618821 ttataagata aagggtaatt aaatacatgc ggaggttgca aatatgaaaa agattgtcgg 2618881 cgctttagcc gtttttgtga ttacatatgc gctgttttca gccgcaggct acctgtttcc 2618941 tgtggaccaa gaatggtaca attcattgaa aaaaccggac tggacgccaa gcggaactgc 2619001 gatcggcatc atttgggcca tcctgtttgc cctgatctcc ctttcagcag ccattgtata 2619061 tgctgcgttt tcatttaaag gtgcgaaaag cttttggttt acacttttga taaattacgt 2619121 gctcaatcaa gccttcagct atttccagtt tacgcaaaaa aatctgctgg ctgcatcgct 2619181 tgactgcctg cttgtcgcca tcacagcaat cgtattactg atcattgcca aaaaatacag 2619241 cagagccgca agctatcttc ttttgcctta ttttttatgg agtgcatttg cgacgttctt 2619301 atcctttaca atcaattcaa tgaatctgtg aacaaaaaaa gccgcttata cagcggcttt 2619361 ttcacatcat cggcttgatg ccccaaatgt ccttcgcata ttcccggatc gtgcggtcgc 2619421 tggagaaata tccagaatga gcaatgttta caatcgaatg ctcagaccat ttccttcgct 2619481 ctcgataatc agcttgaatt cgctcctgtg catctgcata tgagctgaaa tccttcagca 2619541 caaaatactc atcattatgc ggaagcagcg agtcaaagat cgattcaaat tcatctgcct 2619601 ctccttcaaa aaaaccattg atcaactgat ccgctacctg cctgattctc ctgtcatgct 2619661 gataatattc cctcgaccta tagccgccgt tttcctgata cgatagaacc tcatccgcct 2619721 ttaagccgaa cgtgtaaata cagtcagggc ccacccgctc aaggatctcg atatttgcgc 2619781 cgtcatgcgt gccgatcgtc aaagccccgt tcatcataaa cttcatattc cctgtaccag 2619841 acgcttcctt gcttgcggtt gaaatttgct cacttacgtc tgatgccgga aaaattcgct 2619901 cagccataga aactctataa ttttctaaaa aaacaacttt gatcagctgt ttgaccgccg 2619961 gatcataatt gactttttct gcgacagaat ggatcagctt aatgattttc ttggcataat 2620021 aatagcttgg tgaagccttt gccccgaaaa taaaggtttg cgggtagatt gaaaaccccg 2620081 aatcctcctt gaggcggtta tacaaataca taatgtgaag aacattcagc agctgccgtt 2620141 tatatgcatg aagccgtttc acctgtacgt cgaatatgct ctcagggttc acaaccaccc 2620201 cggccgtgca aaaaatcaaa tcggcaagct cttgtttttt cttgcttttg ttgttttgaa 2620261 actgttcaat aaatgcagga tcagtggcgt acggttctaa acggatcagt gattccggct 2620321 gcttgaccca ttcatcgccg atcgcctctg taatgatggc agacaagcct ggattcgctt 2620381 ttaacagcca gcgcctgtgg gcaattccat tcgtcttatt gttaaaacga ttcggaaaca 2620441 gcaagtgaaa gtcgcgcatc tccctttcct ttaatatatc ggaatgtatt tttgcaacgc 2620501 catttacact gtagctgcct actatggcca gatgagccat tttgacaaca ccatgcgctg 2620561 taatcgccat gttctctatc cttttccagt ctccaggata cttttcccaa actgcacggc 2620621 aaaacctctc attgatctct tcaataatca tgtacattcg cgggagcagc ggcttaaaca 2620681 aatgaatcgg ccatttctcg agcgcttctg acaatgttgt atgatttgta taagaaatcg 2620741 tatgtacagt gatatgccaa gcttcttccc agctcatgtt ctcttcatcg agcaaaatcc 2620801 gcattagctc aggcaccgca agcgcagggt gagtgtcatt aatatgaatg ctcacttttt 2620861 tatgcaggcc ggataaagat ttatgtgttt tacggtaatt gttcacaatg ctttttaagc 2620921 ttgcgcatac taaaaaatac tgctgcttca gccgtaaaat tttcccctca tcatgggtgt 2620981 catcgggata taagaattca gaaaccgctt ctgtttctcg cttataagac aaaatattac 2621041 cgccgtgata atgggcatag ggctcggcgt tccaaagcct taacgtgttg acagtgcccg 2621101 tttcatagcc gatgatcggg atatcataag gaacagcggt aacaattgtc gcttgttcat 2621161 ggcgaaaatg caggcgcccg cttttttctg tcatatggac ttcgccccaa aacggcacgt 2621221 ccactgcttg atccgcattc cttacttccc atacgttccc gtttttcagc cattgctcag 2621281 gcagctccac ctgatgtccg tctacaattt tttgctcaaa caaaccatgc ttataacgta 2621341 tgcccatgcc gtgcccaggc aggttcaacg aagcaagcga atctaaaaag caagcggcca 2621401 agcgcccaag tccgccattg ccgagacctg catcgttctc tatctgaagg atctcctcta 2621461 aattgatgcc gatttccttt aaaccagctt ctacaacatc acgaacacca agattcatta 2621521 agttttgctc aaggagctga ccgagcagaa attcgattga taaataatat gtctgcttcc 2621581 cggaatttga tctgcttttt tcattcgttt cgatccaatc agcgctgata tactctctga 2621641 ccatattgcc caacgtttta tattgatcca gcttggcaga atctttaaag ctttttccgc 2621701 acgtcatttc cagacgcttt aaaaataagt ctgcaaagcg ttctttactc gagaacatcc 2621761 cgtccactcc ttgtcacctg ctcgaaaata cgctgatact ctttagccga cttcccccag 2621821 ctgtaatctg cattcatagc ggtcttcacg atgctcttcc atacatcctg ttggcaataa 2621881 aacgacagcg ccctttctat cgtaaatttc agatcatgcg cattaaaggc ggaaaacgta 2621941 aagccattgc ccgttccctc ttcctcctga taggcacgga cagtgtcgta aagaccgccc 2622001 gtttccctga caatcggaat ggcgccatat tgaagagcaa tgagctgccc caaaccgcac 2622061 ggctcaaatt tcgacggcat caaaaacata tcagagcccg cataaatttg atgggctagc 2622121 ggctcatcaa acccgatata agcccggcac ttctcatgaa aagcaaattc tgcataccgg 2622181 aaataatctt caaattcacg ttctcctgtg cctagcacaa ccagctgtat gtcttgctcc 2622241 tcaagaagtt cgtgcataat tctgcggaca agatcaagcc ccttttgttt agtgagcctt 2622301 gtcaccatac tgatcagcgg aatatcgttt ttctctggaa gccccatccg ctgctgaagc 2622361 ttcgttttgt tttccagctt gcatgcaaga tcccctgaat cgtattgcgc ctctatataa 2622421 gggtcgcttt tcggctgata gaacgtatca tcaatgccat ttaatatgcc ggttacatca 2622481 tcttccctat attgcaaaac ctgttccaac tgctcaccat aatacggcgt catgatttca 2622541 tttctgtaag tggggctcac agttgtcaca tgatcagccg caatgatgcc cgctttcata 2622601 aaattaacaa atccgttgca ttctaacctt tcataatgaa aatgatccat ctcaagaccc 2622661 agcaagtcat gtgtgacatc aggagggaat atgccttgaa actgcaggtt gtggatcgtg 2622721 agcacgcttt tcatccgttc ataaaaagga tgttttctgt actcctcttt cagcaaataa 2622781 ttgaccatcg ctgtatgcca atcgtgagta tgaacaatat cggcttgaac attcacaact 2622841 ttggcagcct ccagcacagc tcttgaaaaa aaggcaaacc gctcaccgtc atcataatgc 2622901 ccgtacaacg aatccctgtt gaaatagtac tcattgtcga tgaagtaata attcacatca 2622961 ttctctgcca tatgttcaat tccgcaatat tgctgccgcc agccgacagc tacggtacac 2623021 tcagcctgtt ttttcatacg ctttttccac ggttcaggta tttggctgta cttcggcagc 2623081 atcacagcta cctcattgcc taatcgcgca agcgcctttg gcagagcacc tgctacatcg 2623141 gcaagacctc ctgatttcac aaatggggtg cattctgaca cagcaaataa tatcttcaag 2623201 aattcatcag ctctccttgc accaaacctt ttcttaatac aagcggctgc tcagctgttc 2623261 ctgcagcttc cgtcgccttg ccgattttaa catccttatc cgaaatgacc tgctcaagaa 2623321 gacaatcctc tccaatctgc gttttttgca taataatgca gtttttcagc ttcgtaccct 2623381 ttccgacatg gaccgccctg aacaaaatgc agttttcaac ctctccttca agcacacagc 2623441 cgtttgccac caaagaattt ttgacagtgc tgtgctttcc gtatttcgta ggcggctcat 2623501 ccttcacttt tgtatagatc ggctgctgcg gcaaaaacac ctgctgccaa aaacgaggct 2623561 gaatgagctc catactgtgg gtataatatt tttccaccga atcaatgaca gcggcataac 2623621 ctgaatattc ataagggcaa atggtcaggg cggaagattc cttttcaaca gcctcctgaa 2623681 tggttttata gcctttttcg ctatgtccgt agatcagatc ctttaaaagc gttgttgaca 2623741 tgatatagat ttgcagcgac tggccgtcct gaaatacctc ggtgacgtcg cagccaacct 2623801 cctgatggcg tttcagcaca tattgaaatt gaatgttgca tacggtatgg ctgttggaga 2623861 ttacagcata ttgctgagtg cttctgtgga agtaatctag atggtccgaa aactggcgaa 2623921 aggaaccgaa ttcatcgtat tcgtgatgaa gatggggaga cgggaaaaaa aagaggccgt 2623981 cctttttccg gtgcaaatcc cattccttac ccgccccaag gtgatccatg agcgaacggt 2624041 aacgatactt cggaaaaatt gcaacactcc taatatccgc attcaccatg ttggaaagca 2624101 taaaatcaat cagtcggtac ctgccggcaa aagggatcgc cccgagcgac cgctgtgctg 2624161 ttaaatcctg aagagaatgc ttatatgtgg tttcatctat aacacctaac atttgattat 2624221 tgaacactga ctctgccccc tcttcagtaa ttaaatcaat tctttttcta caaattcctc 2624281 tgaaacgagc agcacctctt caatgtcttt ttcggagcga atcactgcgc catccggcag 2624341 caccatccca ttaggaacga tggcattttc aatgactaca tgctccccaa tcgtcacatc 2624401 cggcattatg acggatgatg taacagtcgt atgcttacca acagtcacac cttgaaaaag 2624461 aacggagtga gacacatttc catatacaac acaaccttcg ttcacaagcg aatcttgaac 2624521 ctgcgcatca gatgaaataa attgcggagg ctgatttgga ttgacggagt aaattttcca 2624581 tttgcgttca aacagcttca gctccgagtc ctcttttaac aaatccatat tggcttccca 2624641 caagctctgc accgttccga catccttcca atatcccttg aacggataag cagaaagctt 2624701 ctttttctct tccaaaagca gtggaataat gtctttgccg aagtcgtggc tagaataagg 2624761 gttttgatcg tccatctcaa gatactgttt caaaagcggc caattgaata tataaattcc 2624821 cattgaggca agattgctct tagggaattt gggcttttca tcaaaatgtg tgatcgtccc 2624881 atctggattg gccttcatga tgccgaaccg gcttgcttcc tcccagccca cttcgatgac 2624941 agagatggtc acatctgctt tcttttcaat gtgataatca agcattttgc cgtagtccat 2625001 tttgtatatg tgatctcctg ataaaatcag tacatactca ggatcatact gattcaaata 2625061 attgagattt tcataaatgg agcttgccgt ccctttatac catttgactt ctgatgactc 2625121 ggcataaggg ggtaaaaccg tcacgccgcc attatatcta tccaggtccc atgcactgcc 2625181 gatcccaata taggaattca gctcgagcgg ctgatattgc gttaaaatcc cgactgtgtc 2625241 tatgcctgaa ttagaacagt tgcttagggt aaaatcaata atcctgtatt ttcccccgaa 2625301 agatacagcc ggtttggcca tattttttgt taatccgctg agacggctgc ccttcccgcc 2625361 ggcaaggagc atggctacac attgtttttt catcttttta tctctcctct ttttttaacc 2625421 gcccgtaaaa tcgagatgcc gtaagggggg atggtcatcg tgatataaca cggtttatga 2625481 tgaagtgctc cctttttagc cgataacggc tttttgttga tttgccctga gcctccatat 2625541 gtttcactgt cactgttaag cacttcaatg tattgagtaa aaaaaggaac tccaacatca 2625601 tattgatgat agaccacggg tgtaaaatta caaatgatga caagcgcctc accgtgcttt 2625661 tggccataac gaataaaaga aaagattgat tgttcgtcat tatggacatc aatccattca 2625721 aacgattgtg cacgatggtc atgctcataa aggattttgc ttttttggta aaagcggaga 2625781 agatcttgcg taaaaacgct ggctttctga tgcatgggga aggagtccaa aaaccaatca 2625841 agctgttctg tatctttcca ttcatcaaat tgagcaaact ctgatcccat aaagatcaat 2625901 ttctttccgg gatgcactgt catatagccc agcaaaagcc gatactgggc aaatttctgc 2625961 cagtagtcgc caggcatttt attgagaagt gatttttttc cgtatacgac ttcatcatga 2626021 gaaaacggca atacaaaatg ttcactaaac gcatatagta atgaaaaaga gataagctga 2626081 tgacaatgcc gcctttcttc gggcggcgtc tccatgtatt tcagtacgtc attcatccat 2626141 cccatattcc atttataatg aaaaccaagc cccccttcct caacggcacc tgtcacttga 2626201 ggccattctg tagaatcttc tgcaatcatc atcacatggg gatatgcctc tctcatggtt 2626261 tgattgagtt tttttaaaaa atcaacagca tatggattcg tgtggcgttc atcctgattt 2626321 ggccaataca agatattagc cactgcatca accctaaatc catctatatg atagaattcc 2626381 gcccagtaca acgcattcga aattaaaaaa ctatgaactt ccggtttccc caggtcaaag 2626441 tttgccgtgc cccataacca gttctcccga tcacgttctt ctttgtattc ataaagcggt 2626501 tctccatcaa acatataaag gccatgtgca tctttacaaa aatgtccggg gacccaatcc 2626561 aaaatgactc cgatattttg ttgatgacat tcatccacaa acttcatcag atcatgcggc 2626621 gggccaaacc tgcttgtcgg gctgtaatac cccgttcctt ggtaccccca tgaacgatca 2626681 tatggatgct catacacggg aagcagttca atatgggtaa acccatgctt cttgatataa 2626741 gggataagcg tctgacttaa ttctttatag gaataatgcc tgccatcaga atgcttcttc 2626801 caagacccaa gatgcagttc ataaatgaaa acaggttttt catacagcgt cttagccttc 2626861 tgtttctttt gccatttttg atcttgccag ctgtatcctt ccaaatcgta agtaagtgac 2626921 gctgtgtttg gtctgacttc tgaataaata gcgtatggat ctgccttcag cctgatctca 2626981 ccgttattcg tcacaatttc gtatttatat cgttcctttt ctcctatacc tggaataaat 2627041 aacgtccaaa tgccattatc attcactctg tgcatcacat gctcttctcc agaccagctg 2627101 ttaaaatctc cagccactcg tacttccgac gcatgaggcg cccacacaca gaattcatat 2627161 ccgcttttgc cattcagctc gcggtaatgc gagccaaaca gctgatagct tttaaacaga 2627221 ctgccttcgt gaaaaagata aacatcatgt gctgtcgggc tggcagcggc catgtaatca 2627281 tcctttctga catcatagtt ttcatttata gtatttattc gaagaaataa aaaaaagccc 2627341 tttcctgaaa gcgcttatac ttatagacaa ttaacttcat tttctgaaga aaaacgaaat 2627401 atatggagat ttttgtagtc tgtttttaaa ataaagaaca aaatctaaga catatcatga 2627461 tttataaaaa caaaaaaacc ttgcaggata tgcaaggctt ctggatgacc cgtacgggat 2627521 tcgaacccgt gttaccgccg tgaaagggcg gtgtcttaac cgcttgacca acgggccgat 2627581 aattatgata tctgtaatca tatggcggag aaggagggat ttgaaccctc gcgccgctta 2627641 cacgacctac acccttagca ggggcgcctc ttcagccact tgagtacttc tccatttggc 2627701 tccacaggca ggattcgaac ctgcgaccga tcggttaaca gccgatagct ctaccactga 2627761 gctactgtgg aacaaaagtc atggtgggcc tgaatggact cgaaccatcg acctcacgct 2627821 tatcaggcgt gcgctctaac cagctgagct acaggcccat gacgatatag aaatggagcg 2627881 ggtgatggga atcgaaccca cgacatcagc ttggaaggct gaggttttac cactaaacta 2627941 cacccgcaat ttttatttgg ggcgattgat gggaatcgaa cccacgaatg ccagagccac 2628001 aatctggtgc gttaaccact tcgccacaac cgccaaagca tattgataaa tggtggctcg 2628061 ggacggaatc gaaccgccga cacacggatt ttcagtccgt tgctctacca actgagctac 2628121 cgagcctaag tatttaaatg gcggtccgga cgggactcga acccgcgacc tcctgcgtga 2628181 caggcaggca ttctaaccaa ctgaactacc ggaccatttt aaaatttggt tgcgggggca 2628241 ggatttgaac ctgcgacctt cgggttatga gcccgacgag ctaccgaact gctccacccc 2628301 gcgatgatta ggaatatgta tggcggagga agagggattc gaacccccgc gggctttgac 2628361 acccctgtcg gttttcaaga ccgatccctt cagccagact tgggtattcc tccgtatagt 2628421 ggtggacctt gtaggactcg aacctacgac cggacggtta tgagccgtct gctctaacca 2628481 actgagctaa aggtccattg gtagcggcgg aggggatcga acccccgacc tcacgggtat 2628541 gaaccgtacg ctctagccag ctgagctaca ccgccaaata tttttgaaat caagtggagc 2628601 ctagcgggat cgaaccgctg acctcctgcg tgcaaagcag gcgctctccc agctgagcta 2628661 aggccccaag aatggtcggg aagacaggat tcgaacctgc gaccccatgg tcccaaacca 2628721 tgtgctctac caagctgagc tacttcccga tttcatatag atcatggcgc gcccgagagg 2628781 agtcgaaccc ctaacctttt gatccgtagt caaacgctct atccaattga gctacgggcg 2628841 caaaacttaa tgccgagggc cggacttgaa ccggcacggt agtcacctac cgcaggattt 2628901 taagtcctgt gtgtctgcca attccaccac cccggcgtgg atggtatagt tggagcggaa 2628961 gacgggattc gaacccgcga cccccacctt ggcaaggtgg tgttctacca ctgaactact 2629021 tccgcagaaa tggtgcggat gaagggactt gaacccccac gtctgtaaag acactagagc 2629081 ctgattctag cgcgtctgcc aattccgcca catccgcaac atgtaaatgg tgagccatga 2629141 aggactcgaa ccttcgaccc tctgattaaa agtcagatgc tctaccaact gagctaatgg 2629201 ctcttcttac aatagacttg aatattatat catataaaag tggtgccggc aagaggactt 2629261 gaacccccaa cctactgatt acaagtcagt tgctctacca attgagctac accggcatat 2629321 atgtaaaacc gatatgtata atgaaaaatg gtggaggatg acgggctcga accgccgacc 2629381 ctctgcttgt aaggcagatg ctctcccagc tgagctaatc ctccatactt gcactaacgt 2629441 gcaattgctt ggcggcgtcc tactctcaca gggggaaacc cccgactacc atcggcgctg 2629501 aagagcttaa cttccgtgtt cggtatggga acgggtgtga cctcttcgct atcgccacca 2629561 aacaaattga gagtgttctc tcaaaactag ataacaggtg tgacatcatt caaaaatatg 2629621 gttaagtcct cgatcgatta gtatctgtca gctccatgtg ttgccacact tccacctcag 2629681 acctatcaac ctgatcatct ttcagggatc ttacttcctt gcggaatggg aaatctcatc 2629741 ttgagggggg cttcatgctt agatgctttc agcacttatc ccgtccgcac atagctaccc 2629801 agcgatgccc ttggcagaac aactggtaca ccagcggtgc gtccatcccg gtcctctcgt 2629861 actaaggaca gctcctctca aatttcctgc gcccgcgacg gatagggacc gaactgtctc 2629921 acgacgttct gaacccagct cgcgtaccgc tttaatgggc gaacagccca acccttggga 2629981 ccgactacag ccccaggatg cgatgagccg acatcgaggt gccaaacctc cccgtcgatg 2630041 tggactcttg ggggagataa gcctgttatc cccggggtag cttttatccg ttgagcgatg 2630101 gcccttccat gcggaaccac cggatcacta agcccgactt tcgtccctgc tcgacttgta 2630161 ggtctcgcag tcaagctccc ttgtgccttt acactctgcg aatgatttcc aaccattctg 2630221 agggaacctt tgggcgcctc cgttaccttt taggaggcga ccgccccagt caaactgccc 2630281 acctgacact gtctccccgc ccgataaggg cggcgggtta gaaggtcaat acagccaggg 2630341 tagtatccca ccgatgcctc caccgaagct ggcgctccgg tttccaaggc tcctacctat 2630401 cctgtacaag ctgtaccaac attcaatatc aggctgcagt aaagctccac ggggtctttc 2630461 cgtcctgtcg cgggtaacct gcatcttcac aggtactata atttcaccga gtctctcgtt 2630521 gagacagtgc ccagatcgtt gcgcctttcg tgcgggtcgg aacttacccg acaaggaatt 2630581 tcgctacctt aggaccgtta tagttacggc cgccgtttac tggggcttca attcgcacct 2630641 tcgcttacgc taagcgctcc tcttaacctt ccagcaccgg gcaggcgtca gcccctatac 2630701 ttcgccttac ggcttcgcag agacctgtgt ttttgctaaa cagtcgcctg ggcctattca 2630761 ctgcggctct ctcgggcttg caccctaaca gagcacccct tctcccgaag ttacggggtc 2630821 attttgccga gttccttaac gagagttctc tcgatcacct taggattctc tcctcgccta 2630881 cctgtgtcgg tttgcggtac gggcacctct cacctcgcta gaggcttttc ttggcagtgt 2630941 ggaatcagga acttcgctac tatatttcgc tcgccatcac agctcagcct tatgggaaac 2631001 ggatttgcct atttcccagc ctaactgctt ggacgcggat atccaatacc gcgcttaccc 2631061 tatcctcctg cgtcccccca ttgctcaaat ggtgaggagg tggtacagga atatcaacct 2631121 gttgtccatc gcctacgcct ttcggcctcg gcttaggtcc cgactaaccc tgagcggacg 2631181 agccttcctc aggaaacctt aggcattcgg tggaggggat tctcacccct ctttcgctac 2631241 tcataccggc attctcactt ctaagcgctc caccagtcct tccggtctgg cttcacagcc 2631301 cttagaacgc tctcctacca ctgttcgaag aacagtccgc agcttcggtg atacgtttag 2631361 ccccggtaca ttttcggcgc agagtcactc gaccagtgag ctattacgca ctctttaaat 2631421 ggtggctgct tctaagccaa catcctggtt gtctaagcaa ctccacatcc ttttccactt 2631481 aacgtatact ttgggacctt agctggcggt ctgggctgtt tccctttcga ctacggatct 2631541 tatcactcgc agtctgactc ccaaggataa gtcattggca ttcggagttt gactgaattc 2631601 ggtaacccgg taggggcccc tagtccaatc agtgctctac ctccaagact cttaccttga 2631661 ggctagccct aaagctattt cggagagaac cagctatctc caggttcgat tggcatttca 2631721 cccctaccca cacctcatcc ccgcactttt caacgtgcgt gggttcgggc ctccattcag 2631781 tgttacctga acttcaccct ggacatgggt agatcacctg gtttcgggtc tacgaccacg 2631841 tactcatgcg ccctattcag actcgctttc gctgcggctc cgcatcttct gcttaacctt 2631901 gcacgggatc gtaactcgcc ggttcattct acaaaaggca cgccatcacc cgttaacggg 2631961 ctctgactac ttgtaggcac acggtttcag gatctctttc actccccttc cggggtgctt 2632021 ttcacctttc cctcacggta ctggttcact atcggtcact agggagtatt tagccttggg 2632081 agatggtcct cccggattcc gacggaattt cacgtgttcc gccgtactca ggatccactc 2632141 aggagagaac gaagttttga ctacagggct gttacctcct atggcgggcc tttccagacc 2632201 tcttcatcta cctcgttctt ttgtaactcc gtacagagtg tcctacaacc ccaagaggca 2632261 agcctcttgg tttgggctga tcccgtttcg ctcgccgcta ctcagggaat cgcatttgct 2632321 ttctcttcct ccgggtactt agatgtttca gttccccggg tctgccttct catatcctat 2632381 gaattcagat atggatacca ctccattacg agtggtgggt ttccccattc ggaaatctcc 2632441 ggatcaaagc ttgcttacag ctccccgaag catatcggtg ttcgtcccgt ccttcatcgg 2632501 ctcctagtgc caaggcatcc accgtgcgcc ctttctaact taaccgttaa aaagaatcac 2632561 tatgtgatat cttgtgttac taattgaatg tgatgtctac tgttatctag ttttcaaaga 2632621 acacgtttcg aaggaatgat ccttcaaaac taaacaagac agggaacgtt ctgtttataa 2632681 gaccttgggt cttatattcc gtataatatc cttagaaagg aggtgatcca gccgcacctt 2632741 ccgatacggc taccttgtta cgacttcacc ccaatcatct gtcccacctt cggcggctgg 2632801 ctcctaaaag gttacctcac cgacttcggg tgttacaaac tctcgtggtg tgacgggcgg 2632861 tgtgtacaag gcccgggaac gtattcaccg cggcatgctg atccgcgatt actagcgatt 2632921 ccagcttcac gcagtcgagt tgcagactgc gatccgaact gagaacagat ttgtgggatt 2632981 ggcttaacct cgcggtttcg ctgccctttg ttctgtccat tgtagcacgt gtgtagccca 2633041 ggtcataagg ggcatgatga tttgacgtca tccccacctt cctccggttt gtcaccggca 2633101 gtcaccttag agtgcccaac tgaatgctgg caactaagat caagggttgc gctcgttgcg 2633161 ggacttaacc caacatctca cgacacgagc tgacgacaac catgcaccac ctgtcactct 2633221 gcccccgaag gggacgtcct atctctagga ttgtcagagg atgtcaagac ctggtaaggt 2633281 tcttcgcgtt gcttcgaatt aaaccacatg ctccaccgct tgtgcgggcc cccgtcaatt 2633341 cctttgagtt tcagtcttgc gaccgtactc cccaggcgga gtgcttaatg cgttagctgc 2633401 agcactaagg ggcggaaacc ccctaacact tagcactcat cgtttacggc gtggactacc 2633461 agggtatcta atcctgttcg ctccccacgc tttcgctcct cagcgtcagt tacagaccag 2633521 agagtcgcct tcgccactgg tgttcctcca catctctacg catttcaccg ctacacgtgg 2633581 aattccactc tcctcttctg cactcaagtt ccccagtttc caatgaccct ccccggttga 2633641 gccgggggct ttcacatcag acttaagaaa ccgcctgcga gccctttacg cccaataatt 2633701 ccggaaaacg cttgccacct acgtattacc gcggctgctg gcacgtagtt agccgtggct 2633761 ttctggttag gtaccgtcaa ggtaccgccc tgttcgaacg gtacttgttc ttccctaaca 2633821 acagagcttt acgatccgaa aaccttcatc actcacgcgg cgttgctccg tcagactttc 2633881 gtccattgcg gaagattccc tactgctgcc tcccgtagga gtctgggccg tgtctcagtc 2633941 ccagtgtggc cgatcaccct ctcaggtcgg ctacgcatcg ttgccttggt gagccgttac 2634001 ctcaccaact agctaatgcg ccgcgggtcc atctgtaagt ggtagccgaa gccacctttt 2634061 atgtttgaac catgcggttc aaacaaccat ccggtattag ccccggtttc ccggagttat 2634121 cccagtctta caggcaggtt acccacgtgt tactcacccg tccgccgcta acatcaggga 2634181 gcaagctccc acctgtccgc tcgacttgca tgtattaggc acgccgccag cgttcgtcct 2634241 gagccaggat caaactctcc gataaatgga tcacaggtta agttcaccgc atcctgcggc 2634301 gacacctgtg tgacctgcgt cgtgcaggcc ctagtttgac tgactacgca catcgcagtg 2634361 cgatttttaa aaactgaatt aacaggtacg ttttgtcttg tttagttttc aaagatcatt 2634421 tcgttacttc tcaatgaagc agctttacta atataacatt cagcttcttt tttgtcaaca 2634481 acttttttca agttgttttg aagcatctag tttgtgtccg ctgtgcatca gcgacgttta 2634541 ataatataac acctgtattt atttattgca atagtttttt aaaaaaaatc tataaaacaa 2634601 ataaactata atcctcgcca tgatttctaa agcgtgtgta tcatataagt ttcttaaaag 2634661 aacatataca tcagtcatgt gatcttgttg tttttttcgt tttcttgtat agtagaaacg 2634721 aactaaatac tgatgaccac aaggggagca ttaaagctga gagtgagcgg tttcgttctg 2634781 accctttgaa cctgttagtt aacgctggcg tagggatgtg gcaaagtcaa atgaattgca 2634841 gatcgtaaag cagtgcgtgg aacttttctc atccttccgc gtgctgcttt tttgttgtcc 2634901 ttttggttgt ctgtcaatgg aaggagatag atatgaatca atctaagcaa ctggttcgcc 2634961 ttattgaaat tgccattatg acagcggcag ccgttatttt agacattgtc tcaggaatgt 2635021 ttcttagcat gcctcaagga ggctcggtct ccatcatgat gattccgatc tttttaattt 2635081 cgtttcgctg gggtgtcaaa gcaggtctta ctacaggttt gttgacaggt ctagtacaaa 2635141 tagcaatcgg aaacttgttt gctcaacatc ctgtacagct attgttagat tacattgtcg 2635201 ctttcgcagc aatcggcata agcggctgtt tcgcttcttc tgtccgtaaa gccgctgtat 2635261 caaaaacaaa agggaaattg attgtttcag tggtcagcgc agtttttatc ggcagtttgc 2635321 tgcgctatgc cgcgcatgtc atttcaggag ctgtgttttt cggcagcttt gctccaaaag 2635381 gaacaccggt atggatttat tctttaactt ataatgcgac ttacatggtt ccttcattca 2635441 ttatttgtgc aattgtccta tgtttattat ttatgacagc accccgtctg cttaaaagtg 2635501 acaaagcgta aaagtaacaa tcccccagcg aattccgctg ggggattttt cgttatctgt 2635561 taagaagtgt ttttaaagct gaaagatccg gccagccaag acctacttct ttcagcctta 2635621 ctccggcaat ttcaaagttg tcctccgcta ctctttcagg tgaataggcc tgataaaata 2635681 taatcgaggg attctgctca ataacccaaa caaacatact tgaaaaacca tgttgaagca 2635741 aaaactccgc tccttttgct aagagcgccc tgcctgcacc ttgccgctgg cgctcttcca 2635801 gaagataaat agcgtataac tcgccgtcat agccttcttg ttcagagcga ataggtccaa 2635861 atgaagcaaa gccgaatact gaaccctttt cgtcctgagc aacaaatact ccctttaacg 2635921 agcgactttt ccatttgtct tcaaattcct tatagttcag gctgtttaaa taatcaatcg 2635981 ggataatttc gtggtatgtt gtcctccagc tgtctacatg cacttttgca atgtccttta 2636041 tatcctctaa cttcgcttca cgtacagtta ccatacggtt ctgccctttc cttactctga 2636101 tttttggatc gttttggctt ctttgatttc atttgttaat tcattaatgc tttgttttac 2636161 gtttcctttt cctgaaaagt tctcaagcat ttcttttaca tcaattcctg aggatgcttt 2636221 taaactttct tgcagacttg acattaagtt cgtcgcatag ctggttactt tgtttgctcc 2636281 gcttgattca ccgcttcctc ctgtatcgac aacggtgatt ttatcaatat ttgaaagagg 2636341 tgccgctgct tgtttcgcgt attccggaag cattttgaca atcatatcga aaatcgccgc 2636401 ctgcccgtac tgttcaaagg cggccgcaat tttctctttt gcttccgctt ctgcaagacc 2636461 tttcaggcgg ataacctctg cttctgtctc tcctttcgct ttttccgctt ctgcttttgc 2636521 tagcccgtca attcttactt tttccgcctc agcctttgcc attgcttcaa tactgtactt 2636581 cttggcatcg gcttccgcga gctgtttggc tttctcagct gctgcggact gctcaacaga 2636641 ataacggtct gcatcggctt ttttctttac ctctgagtcg tattgacgtt cacggcgaag 2636701 aatttctttt tcttctagtt ctatttgttt ttggcgttcg ataattttaa cctgcatttc 2636761 ctgctctgtg acttgctggc gcgctcgggc agtctctaaa tcatatgctt ggtcggcatt 2636821 cgcttttgcc gtatcttgtt ctctgcggaa ttcagccatt ttgagctgat tgattttttc 2636881 agcttcagcg atttccgtcg cccgttcaag ttctgatttt tttgcgtctt tatcggcttc 2636941 tgcccgctta attcgggttt ctttatcagc ctctgctgtt gcgatatcag catcgcgttt 2637001 tacttgggca attctcggtt tccctaatga ttcaagataa ccgtttttat cacgaacatc 2637061 tttaatggta aacgagacga ttacaagtcc cattttcgcg agatcctgtg aagcgacacg 2637121 ctgcacctct tgagagaatt tttctctgtt tttatagatt tcttctactg tcattgagcc 2637181 gagaatggaa cgaaggtggc cttctaaaac ctcccgcgct tcctgctcac ggtcgtcttt 2637241 tgatttccct aaaaattgtt cggccgctgt agcgatttct cctatagaac cgccgatttt 2637301 aataatcgca gttccatcgg ccattactgg cactccttgt tctgtataga cttcaggtgt 2637361 cgaaacatcg agtttgcttg ataataggct tagcggctct gcctgctgga agacgggaag 2637421 gacaaaggtt cctccgccgc ggacgatttt aatacggttg ccgccttcat cgacatgaac 2637481 atttttatta cccagatagc tccctgttac aattaacgct tcatcaggcc ctgctgtacg 2637541 atacttcgta ataaacacag ctattagtgc aattaataaa aagaatacaa ctccgatgat 2637601 cattataatc ggcattgtca tatcaaattc ctccttttat gttaaatggg ttcatgcgga 2637661 gtaaccgaaa gaactccgtt gttaatatct acgactaaca ccgttgtccc gtaactgatc 2637721 tgctgattat caaaactgac cgctgacttt gaaatggtcc cgcctatccc ttctatgacc 2637781 acttcaccaa acccgtcaac cggcacagct gtaatcactt taccgagtct tcctctgaga 2637841 tcatcttctc tatatgccaa tgattcttct gcagatgata atggcaccag tacaaagatg 2637901 tgaagcaata ccaccagcat gatcgaaagg atgcaagata aaagcgcaat cagcaagctt 2637961 gacagaggca atacaagttc acctatatat ccgcccgctg aaaaacatgt aaaaaatgag 2638021 agcactaatg tcggattaag aaacggaatg ccttctgaca gccctgaaaa tacatctccg 2638081 aaaaacagga ataacagcgt aaggctgccc gcaataataa gcgtataaag atacattgtt 2638141 tgtataggta ctccaaataa ctccaacttc ctcatccttt cttcatcaat gcattgatga 2638201 acggctgccg ttaccattta tacgagacac ctcgggaaaa gtttcaaaat tttaagacaa 2638261 ataacccatt tgaagtgctt tataaatgat aattgcttat atatatggta atgtcatttt 2638321 aggaggagat atgatgagta tctttaatga agccagatta gaaacgtgga acgaattgaa 2638381 aggactttct gacgaaaagc tgaatcaaaa gccttctgct gaagaatgga gcatacggga 2638441 agttcttgac catttgaaaa aaatcgatat gaccgcacaa aaaatgttga aggaacgtgt 2638501 aaaggacgct ccgattaaag aaattgaaga aaaaccgctt gaagtagcac aggacagaaa 2638561 taataaacgg aaagccccga gtcatcttga gcctgcgcat gattttattt caggcagcca 2638621 aatgaaacgt gagcttgatg tggtaagaga gcagctgact gctgcgattg cctctctgaa 2638681 agaagaagat tttgaaagag tgcttccgca tcctgtgttt caagagctga ctgtcagaca 2638741 gtggatcgat tttatcggcc atcatgaaaa acggcacctc agccaaatga aagaaattaa 2638801 agaaaagata gaaagggcct gatttaatca gaccctttct gcttttcgtt tgacttttcg 2638861 ctgataggaa tgaacttcta tttcatcacc tgtgtaaaca gcaccaggtc tctccacaat 2638921 acagacaatc cctctaatgc ccagtgcgtg gcggacgaaa gccgacgcca gcttcggttg 2638981 gtccggataa taagactgaa tgacttctcc cggctggata cacggatcat tttcgccctc 2639041 acacagcaga gccgctccgc tcggaaaaat aatccggctt ccttctttta atgaagtaag 2639101 atctggcata ccgctgactg ccacattcgc cccgagccat tccggcaaaa ttctcggcac 2639161 tcccattttt aaagcgattt cgttgcattc ctctattgaa acaattgaaa tttgtctgcg 2639221 gttgaaaatt tcagtccctc ttgaaaacat tggttctctg gctcccgctt ttttggtcag 2639281 gccaaaatgc aagtcgccgg ggatgccgcc ataatcaaaa tcaagcttgt ccatttgctt 2639341 tgttacgaag ctttttgtat ctgcgatata taagccttcc gcttttgcag tcatacgctt 2639401 ccacatcagc tggcaccttc cttcttatct aaaatttcca cctatgcttc attatcccaa 2639461 aaaatcccgc tctgtaaagg agcgggattt tgattatacc gttttaggcg taaggttaaa 2639521 gcagcgtttg tagatccagt tgtatgcttt ttcatttaaa tctctagggt ttccgaaggt 2639581 ttgcggatct ttcattgctt ctttagacaa gcgttcgatc atatcaggtg atactccctg 2639641 ctcttctaaa gtcggcactt ctaaatcttc gaccagatca tacatccaat tgacagatgc 2639701 tttcgcagct tcttctgttg tcatcttgct tgtatcaata ccgaacgctt tcgcaatacg 2639761 cgcaaacttc tcaggatagc ccttccagtt gtattccatg acagggccca tcatcgccgc 2639821 tacacattgg ccgtgagcga ctgggataat accgccaagc gtttggctca tcgcatgagc 2639881 agcgcccgct gattcacttc cgtaagaaag accggcaagc atcgcagcct gcgccattcc 2639941 gtaccttgct tccagatcct ctccatcagc aaatgccctc ttgatgtaat gagcggcata 2640001 ctcaatcgcc attaaggcaa ccgcatccgt gattggctgt gcaaatttca ttgtatagca 2640061 ctcaatggca tgggcgagcg catcaattcc cgtcatagct gttacatgcg gaggcattga 2640121 aacatgaagc tcaggatcaa tgattgtcaa gtgcgctgca atcagcggac cgcccgtgtt 2640181 gaatttgaat tctctttctt catctgtgat aaccgcccat tgggttactt ctgatccggt 2640241 tccagctgta gtgggaattg tcgtcagcgg aggaatgcgg ttttccagcg gttttttccc 2640301 atctgccgct tcataatcaa gcacgcttcc ttcgtgagtc gcttctactc cgattgcttt 2640361 tgctgtatcc atggagcttc cgcctccgac tgccaccaaa ccattacagt tctctttttt 2640421 gtaaagctca gatccttcat tcaccagacg gacaggcggg tttggctcaa ctttattaaa 2640481 gagtaccact tcaatgcctg cttctttaag tgattcgatt acgggatcag caacaccggc 2640541 tttataaatc ccagggtctg tgacaaggag cgcttttgaa acgcccagtg cagctacttc 2640601 ctcacccgta tgcttgatgg ctccgattcc atgcttaatc acagtcggaa tttcaaatgt 2640661 gtggaatttc tgcatgcttt ctaccttcat atttaatgtc atcatcaatc tccccctctt 2640721 atgaattaaa ccagttaacc gctgccggtt ttgtattgcg gtatacatgt ttgacttctg 2640781 tgtattcttc aaggcctatt tttccaagct cgcgtccgaa cccggattgc ttatatccgc 2640841 cccatggcgc ttgtgcaaag tacggatgaa aatcgttgat ccaaacggtt cccattctca 2640901 agcgggctgc tacccgttcg cacttttcaa tgtcttttga ccataccgct ccagccaagc 2640961 catagatggt atcattcgca agctcgatta cctcttcttc agagctgaag gtttcgactg 2641021 tcaatacagg accgaaaacc tcttcctgaa cgattctcat gtcagaatta cagtttgaga 2641081 aaatagtagg ttcatagaaa aagccgtttt gaagctcagg atcttccggg cgtttgcctc 2641141 ctgtctccag cttcgcgcct tcctctattc cgatctctac atatttttct acctttgccc 2641201 tgtgctccgc cgaaataagc ggaccgcttt ctgtctcagc atgaaaaccg tttccgagtt 2641261 ttatgcgttt tgcccgtttg accagctccg ccaaaaattg atcatgaatg gcatcctcaa 2641321 caagcaagcg ggaacctgca gagcatactt ggccggcgtg gaaaaataca gcgtttaagg 2641381 cctgatcaac cgcaacttct aaatccgcgt ccttgaaaac aatatttggg tttttcccgc 2641441 caagttcaag ggcgattttt ttgacgtttc cgcttgccgc ccgcatgatt tttttgcctg 2641501 tttcaattcc gcccgtaaat gaaatcaaat cgacgtcttt gtttacggca agctcgtcgc 2641561 ccactgtggc tcccggtcca agaacaagat ttgcgacacc ttttggaaca ccggcttctt 2641621 ccatcagctt aaagactttg attgtcgtca gcggcgtaat ctcactcggc ttcatgacga 2641681 ttgtgtttcc tgcggccagt gcaggggcga ttttccagct cgcttgaagg agcggataat 2641741 tccatggagt gatctggccg caaaccccga ttggctccct aataattttg ctttctgaat 2641801 caggaatcgg agatgaaatg atctctccgc catctttgtc tgccaagccg gcgtaatatt 2641861 gaaaaacatt ggcgatatcg tccatatcgg ccttgctttc ttcgagtgtt tttcctgtat 2641921 caagagattc aagctcagcc agctcctcaa gatcgcgtct gattaattcc gcaattttca 2641981 gaacaatttt tccgcgttca agcccggata gcgatgacca ttctcctttg tcaaatgctc 2642041 tacgtgcggc tgcgattgct ttgatggcgt cctctcgccc tccctcgctt acagttgcaa 2642101 tttcttcttg attaaatggg ttgataatac tgcggatctg ttctttttcg gcactgatcc 2642161 attctccgtc aatgaataat gtttgactca tataagcctc cttgacgtaa ataaagtttg 2642221 ttaaataaaa atttaatgtt tttaacaacc ttaatctaac atatggtttt taaactgtca 2642281 aagtcccatt ttgatttttc tttttgactt ttcctcatgt ttcgttaaga taaagaacat 2642341 aaagaaataa cttaacgaat ttaattttct aaaggaaaag agggtcagta tggatgaaaa 2642401 tccagaattt gcagctatag aacaggctcg ggatcttgtt attgactcca ttgctgaaac 2642461 gatggatctt tacggaatta cccgcagtgt cgggatttta tatgggacga tgtatatgag 2642521 ggatgagatg acgcttgacg aaatgcgtga ggagttgcaa atgagcaaac caagcatgag 2642581 cactggcgtc aaaaagcttc aagacttaaa tgtagtgaaa aaaacatttc accggggcat 2642641 ccgcaagcat acatttgtgg ctgagaagga tttctttaaa tttttcacaa atttctttcc 2642701 acctaaatgg gagcgggagg ttcaagtgaa tgtaacagcg atcgaggaag ctcaagctga 2642761 tttacaaaag gttttatgca aggaagatct cgatgaggat atcaaaaatg aagcactgca 2642821 gttatatgat cagctggaaa gctctaaagc ttactatgac tggctgaaac ggcttgctga 2642881 atcggtgcag accggagaaa tttttaaatt tataccggtc gaaacaaagt aaagcagaaa 2642941 acgcctggga aactaggcgt ttttttgatg taactactac aaatttgaaa aatacgggaa 2643001 aaacacccca tttacttcca aaatatttga tggtaatttt atgtaggtaa aatttgtatt 2643061 tggcctttca gaggaggtga aaagcgggca ggcctgttta atttatcatt ttttaggggg 2643121 aattttgtta tgaaacgcaa attattatct tctttggcaa ttagtgcatt aagtctcggg 2643181 ttactcgttt ctgcacctac agcttctttc gcggctgaat ctacatcaac taaagctcat 2643241 actgaatcca ctatgagaac acagtctaca gcttcattgt tcgcaacaat cactggcgcc 2643301 agcaaaacgg aatggtcttt ctcagatatc gaattgactt accgtccaaa cacgcttctc 2643361 agccttggcg ttatggagtt tacattgcca agcggattta ctgcaaacac gaaagacaca 2643421 ttgaacggaa atgccttgcg tacaacacag atcctcaata acgggaaaac agtaagagtt 2643481 cctttggcac ttgatttgtt aggagctggc gaattcaaat taaaactgaa taacaaaaca 2643541 cttcctgccg ctggtacata tactttccgt gcggagaata aatcattaag catcggaaat 2643601 aaattttacg cagaagccag cattgacgtg gctaagcgca gcactcctcc gactcagcct 2643661 tgcggttgca actaatgtaa aagaccggtt aacgccggtc ttttttgcgt tttaccctcc 2643721 cctttttctc taatccccgt tatctttttt ctggtttaaa atttaaattg acaaacacta 2643781 gaaacaggag taaattcttg agtgttcaat ttcatacagt ctcttttacc gcttaatcaa 2643841 acacgaacgg gggaaccaac gattggctgt tttattaaca gccttggggt gaatcttact 2643901 aagtaagagg gggtactctg aatccctaat ccgacagcta acctcgtagg cgtatacaga 2643961 gaggaggtct attatcggcc attctttgca atggtctttt ttgtttcaaa aacgttaatt 2644021 cactaaggga gatatgaaca ttgggaagaa ttaaaaataa gcaatttgcc gtgatcgggc 2644081 tgggccggtt tggcggcagc atttgtaaag aacttcatag aatggggcat gaggtccttg 2644141 cggttgatat caacgaagaa aaggtcaatg catatgcttc ttacgccact catgcggtaa 2644201 ttgccaacgc caccgaagaa aacgaattgc tttcattagg aatacgcaat tttgaatatg 2644261 tgattgttgc catcggagca aatattcaag cgagtacgct gaccacccta ttattaaagg 2644321 agcttgatat tccaaatatt tgggtgaagg ctcaaaacta ttatcatcac aaggtgcttg 2644381 aaaaaatagg cgctgaccgc attattcatc ctgaaaaaga tatgggggtt aaaatcgcac 2644441 aaagcctttc agacgaaaat gttttgaatt acattgatct atctgatgaa tacagtattg 2644501 tcgagctgct ggctacgcgc aagcttgatt caaaatcgat tattgacctg aatgtaagag 2644561 caaagtacgg ctgcacgatc ctggccatta aacatcatgg agatatctgt ctttcccccg 2644621 cgcctgaaga catcattcgc gagcaagatt gcctggtgat catgggccac aaaaaggata 2644681 ttaaacgttt tgaaaacgaa gggatgtaga caaaggtgac acttcaaaag gataaagtga 2644741 tcaaatgggt tcggtttaca ccgcctcaag tgcttgccat tggttttttc cttaccatta 2644801 tcatcggggc tgtcctatta atgcttccga tttccactac gaagccattg tcatggatag 2644861 atgccctttt tactgcggct tccgctacaa ctgttacagg gcttgctgtt gtcgataccg 2644921 gcactcaatt tacggtattc gggcaaacag taattatggg gctgattcag attggcgggc 2644981 ttggatttat gacatttgcg gtcttgatcg tcatgatatt aggaaaaaaa atcggcttaa 2645041 aagaacgaat gctcgtccag gaagccttaa accagccgac aatcggcggt gtcattggcc 2645101 ttgtcaaagt cctgtttctg ttttcgatca gtattgaatt gatagcagca ctcattttat 2645161 ccatccggct tgtacctcaa tacggctggt catccggctt gtttgcaagt ttgtttcacg 2645221 caatatctgc ttttaacaat gccgggtttt cgttgtggcc tgataatttg atgagctacg 2645281 ttggcgatcc tacagtgaac ctcgtgatta ctttcttatt tattacagga gggatcggat 2645341 ttacggttct gtttgatgtg atgaaaaatc ggcgttttaa aactttttct ttacatacaa 2645401 agctcatgct tacaggaacg ctgatgttga atgcgatcgc tatgcttacg gtctttattt 2645461 tagaatacag caaccccggc acgctcggcc acctgcatat agtggataaa ctgtgggcct 2645521 cctattttca ggcagtgacg ccgagaaccg cagggttcaa ttctctagat tttggaagca 2645581 tgagagaagg aacaattgta tttactttat tattgatgtt tatcggagca ggaagcgcat 2645641 caacggcgag cggcattaag ctgactacgt tcatcgtgat tttaacatct gttattgctt 2645701 acttgagagg taaaaaagaa acggttattt tccgccgttc catcaaatat ccgattatca 2645761 ttaaagcttt agctgtgagc gtcaccagtt tgttcatcgt gtttttaggg attttcgccc 2645821 tgacgatcac agaacaagcg ccatttcttc aaattgtgtt tgaaaccttt tccgcattcg 2645881 gaactgtcgg ccttacgatg gggcttactc ctgaactgac aacagctggc aagtgtatca 2645941 tcattgtcat catgtttatc ggaagaattg gtcctttaac gttcgtgttt tcattcgcaa 2646001 aaacagagca atcaaatatc cgttatcctg atggcgaagt gtttacaggg tgatatcaaa 2646061 aaaatccggc gtgcagtcgc cggatttttt atgattcgat atgagattga ttttgtcttt 2646121 tttcctgttc cgcgatgatt tcgttatcct ccgcgttatc acgggtcact ttttgcgtaa 2646181 gaatcgcacc aactgctaca agtatcataa cagcgatgta ataacctttt tcattgagtt 2646241 ccagattatc agcattatag agtccgatac taaacaaaaa tactcccgca aaaaaagtaa 2646301 aataagctag tactgtaaag gcaaccgtgt ttctgcgtct atatttctgc acctttgttc 2646361 cctcccgaaa gcatagttaa aaagtgataa cttccgtgga atattatacc tcaaattccc 2646421 cggaatggaa caaagaatta aaaataccag taaaaagggc ttaggttgcc tcctttattt 2646481 caacagctga atcatcaatc cagccgataa gtttatcatt gatttggaat tggtaccata 2646541 cagactggcc tttctgtttt ttagacacaa cctttatgtc tttgccgacg taagattggg 2646601 cagaggtaag ccttatggac cgatcatcag tagaaggctt ggaccatacg tcttgaacgg 2646661 cactgtcttt aatagaggcg tttaaatcca cagatttgag ggatggattt acctcatcgt 2646721 actcatctaa atcgtatttt tccacaatag cgctgatttt gtcagcgtag tcagggtctg 2646781 tagcatatcc tgatgtttgc agggcggttg ccgcttcctt ataattccct gcctcaagca 2646841 ccggtttata cttcttttta ttccacgatg tgccacggac gaacaattgg gcgtgatcat 2646901 ccatagattc aaaaaacgtg ctgtattttc gaaacttcgc gcgaatggtt tttcttttcc 2646961 ctttttcaac ttcgtccgtt tccatcgtga catgatggcc tttataattc ccttttacgc 2647021 caaaaaggtt gttggcctta gcagccagtt cactgttccc ccagtccgat tcgagaatgg 2647081 cctgagcaat tgtgatgctg gggagaacat ggtatttttc atacaaaatt tgggcatgtc 2647141 cggacagact gtctataaat acttgctgtt catcgatttc ttcagtttct ttggatattt 2647201 caatcggttt tgataaagtt gtcgctaaaa caaacagagc tagcggaatc gatacaagga 2647261 aaaatagtga aatcaagagt ttacgttttt taagtttttt acgggccatg aaaaccttcc 2647321 ttcgaattaa aagattacga atgtaaaaga atctaccttt tagaatttta cttgcacttc 2647381 taatattttt caattcttta gggataaagt tgggaaaaga ttgcaaaata aaaacctttt 2647441 cgctcaatga aaaggttttt accatgtttc tatttttgta aatttctgag tgcattccga 2647501 tattccgtat catttattac tttatatgat ttgacagttg ccttcgacaa accttgtgct 2647561 gagacggccg gtttttccgg agctgttttc gctttatcat gtggtttatg tgccagcttg 2647621 tgccccattc cagtggcatt catacaaaat gacaggcaga cgagcagcac gctaaggata 2647681 aaagaaatga agaagagatc atgataagca gtcatcatag aatcctgtac cgaaccgctt 2647741 tgtctggcag catctttttt cgtgaaaaag ccgatgagaa tgggaactcc catatagaca 2647801 aacaatctta aaaactgaac agctgtcatt ctcttgacca aatcaggcag cgggcctccc 2647861 atggcagctc ccatcagccc tgcggcgact gtcaggcctg ttcccgctgc aagcatgata 2647921 aacagtgccg cgaacatata aagagatgat cgatcctgta tatgcagcca ttgaaaattc 2647981 acaaaaacga gaatgagtcc gccgataata ccgagcatcc ctggtccgac tttatcgtat 2648041 aacagagcgc tcaaaatggc cgcgatcgcc actccgatta aaagagtcaa gcttaaaaga 2648101 atgagatgct cctgagaaat atcatacatt tgacggagca agccttgaaa agcagaaagg 2648161 ctgacagcta ccgttatcgt ccctgcagct atgatcaata agccgagcac cggttttggc 2648221 agcagcatca gtttaataga tatgaagggg tttttcactt tatattccac aatcaataga 2648281 ccaatgagca aacataacgt caccccgaaa ccaatccata cataacccga tgacagcccc 2648341 catttttgca gaaaaatgaa tgaaaccgct gaggctgcgg caaggaagac agataaaaga 2648401 attcccgcac gatcaagcgg ctgttcttga tccgccgctc cgtgatgctc atcatgaaga 2648461 aagaaatagc tcaccgcgac accgatcagg gacaaggtgc caaagatgaa aaacagccat 2648521 ctccaatgcc cgcagcttgt tgcaatggtt cccaggattg taccgatgat aacagaacca 2648581 tagaatcccc cgatcagcac aagcagtgca tagttcctgc gttcaatcgg gaatgacagt 2648641 acaagcattg gaatcataat catcagcatg acgcctgttg ccgccccttg taaaaagcgc 2648701 cctgccgcca tcaatgcaat atcgcctgaa catgcgatga gcagtgagcc tagtataaag 2648761 acaggtaatg aagccagata gacgggacga gcaccgaatt ttttcctcag cagcggtcct 2648821 gccggaacta acaaggcaaa ggccatattg ccgatcaata tcggatttac tgatgtaaag 2648881 acacttgttc caaccgtttt ctgaacaagg ccttgaactg acgacaatgc cgtgttagac 2648941 atcaatcccg gcccgaccgc taagacggcg agcaaagaaa tcacccaata gtgttttgtc 2649001 ttcatgttgt catcccttcc tatatgaata catgcgaaac acatcatttt ttgaaaacaa 2649061 aagaagctaa tagattttgc ataccattag ctttcattct aatattctcc ctttcagggg 2649121 aaatgatatt attttattat aattatgtga atgaatgagc atataatcaa atattatttc 2649181 aaatcgattg tgttttgtca atggagtaaa tttcaagcac aacatagaaa gcttgaaagc 2649241 ttttccccga tattgtgtct agaactgcac ttatgaatcc ctgctcgttc cctcaagcga 2649301 attaaagcag gccgttttaa tcctttcaat ccactattcc aactaataaa ctcaaataag 2649361 ttggtgataa gacaacattt tacccccaca tttttttgtg ttcactgggc gtttgccgcc 2649421 tctaaattgt atatgggtaa ataccatgaa ttaacctatg aaataccaat gtaagggagg 2649481 caaaaacgaa tggaactgta tgagtgtatc caagacattt ttggcggctt gaaaaatcca 2649541 tcggttaaag atttagcaac gtctttaaaa caaattccaa acgcagcaaa attgagtcaa 2649601 ccgtatatta aggaaccaga ccagtacgct tacggccgaa atgccatcta tcgaaataat 2649661 gaattggaaa ttatcgtgat taacattccg ccaaacaagg agacaacagt acacgatcat 2649721 ggtcaatcca ttggttgtgc aatggtgtta gaaggaaagc ttcttaattc tatttatcgt 2649781 tcaaccggcg aacacgcaga actctccaat tcatactttg tccacgaagg agaatgcctt 2649841 atttcaacca aaggtttaat tcacaaaatg tccaatccaa catctgaacg aatggtgtct 2649901 cttcatgtct actcccctcc tttggaagac atgacggtct ttgaggaaca aaaggaggta 2649961 ttggaaaatt catgattgac agataaactg ctcactttga cttcactcaa ctggaggatt 2650021 cagagaatga aaccttttcc tcaaaacaaa aaaaccctta tcgaataagg gtttaaaggt 2650081 atggagccaa gggggctcga acccctgacc tctacgctgc cagcgtagcg ctctcccagc 2650141 tgagctatgg ccccgtatgt aacgtcatgt ttattataga tgattttatt ttgaaaaaca 2650201 agctgtttcc tcttgaattg acagaaaaaa taaggctcgg aaaagagcct tatttttcga 2650261 cttacatcat gatcaaaagt aaaatcacac cgagaataat tcgatagatt gcaaatggga 2650321 caagtttgat tttgttaatc agccttaaga agaaacggac gacaaacagt gcgaccacaa 2650381 aggcacagat aaagccgacg atgaaaaacg gcatcagatc cgaacttaag ctgtcccaat 2650441 gcttcacgag gcttagaaag ctggctccca tcatgatcgg catcgccata ataaacgtaa 2650501 agtcggctgc agctcggtgg tttaatccga gaataacacc gccggaaatg gttgaacccg 2650561 aacgcgagaa accaggccaa agggaaagac attggaataa gccgacggct atcgcctgtt 2650621 tataggaaat gcggtcgagt gtgtctgtcg ctgttttccg tttattgacc cagtcagcaa 2650681 aaagcatgag gattgccccg gcaattaaac cgatggccac agttttaacg gaaaataaat 2650741 attcatcaat gtaatcttca aacaaaaagc cgagaacagc tgcaggcacg agtccgacgg 2650801 caatttgggc aatgcttaat ttatgtccct gctcctggtc gcttgtaata ttttttttca 2650861 agcccagtaa atttaaaatt cggtctttaa acacgatagc tactgctaaa atggagccta 2650921 gctgaataac caccttgaat gagttagcag cttcttctga catcagatta cttgatttta 2650981 gccagatgtc gtctactatg atcatatgtc ctgtcgaaga aaccggcgcg tactctgtta 2651041 atccttctac gattcctaaa atggcggcta caaacaattc ccatagagtc atgattttga 2651101 ttctccccat tagacattta tttttttaca taacgggagc ttcccataaa tggaaagccc 2651161 gtcttatata actataaacg aaaatcacac tttatgcccc ggcgtatttt catttttttc 2651221 ttcatcgtat aaatgtgact gcattttaaa ccagtcaaat aaatgtgtcg taatgacttt 2651281 ggcaaccgca tagccgggaa tcgcaagaat gattccaaca acgccaaaca gcttgccggc 2651341 tgttaacagc agaaaaataa tcgtaatcgg atggatgtga aggttttttc ccataatttg 2651401 cggagagatc agcttccctt caatcagctg aacaatcgtc caaacgatca ccagcttaag 2651461 cagcatgagc ggcgatgtca ctatggcaat gataatcgca ggcgtaatgg caatcgttgg 2651521 ccctaaatat ggaacgatgc ttgtgcaagc cgcaatgact gcaagcaatg aagcataatc 2651581 cagcccgata atcaaataac cgataaacag caaaaacccg atacagaagc tgacaatgat 2651641 ctggcctctg atataagagc ttaaccgatg attcatttcg cttaagactg tatatgtctg 2651701 ttctttcaat cgagtcggca caaacttcag tatgtagacc ggtaattttc ttccgtcttt 2651761 tagcaaataa aatagaataa acggaaccgt gacgatcgaa atgataatct cagtcagtgc 2651821 gccgataaaa ttcccaacac cggtaaaggt gctgttcacg atcgtcgctg cctgatccga 2651881 aacctttgta gcaagatcag atatattaat gttcatcgtt tgctgggcct gattgacgaa 2651941 gttgctgcca atcagctgtt tcgtctgatt ttctacgacg tccacatatc tcgggatatt 2652001 gtcaatcaaa ctcataattt gttcttttaa gaagggaatg atcgacacga tcgtgatcgt 2652061 gatcagcccg ataaccaata ggtatagcag caatatagaa tagattcttc ttattcttct 2652121 tctctccaga aaatcgacga ctgggtttaa cagataaaaa acaatgcctg tcaaaataat 2652181 cggaagtgat atcgttttga gcagaacaat aatcggggtg aaaataaatg atgtttttgt 2652241 aaatactaga atatttaaac caatcagcag cagcacaagc aaaaataaaa caaacttatt 2652301 atccaagaag aatcgcttga atctgccgct ccatgtttgc aacgtctcca ctatcgttcc 2652361 tccgtcatac atagtttaat taaattgtac actatcgtcc ctataatgaa aaataaaaac 2652421 cgttaattgc tggaaaagct ttctcggttt taacattcta tttatatcta tcatgtgatt 2652481 ttgttctttt taagctataa tttagctata tcatgcaaaa ggagcgatac gagtgatacg 2652541 ttttgcaata ataggaacca actggattac agaccgcttt cttgagtcag cagcggatat 2652601 cgaagatttt cagctgactg ctgtttattc aagatcggct gaacgcgctg gcgagtttgc 2652661 tgctaaacac aacgctgcgc atgccttctc agaccttcag gaaatggcgg cgagcgattg 2652721 ctttgatgcc gtatacatag cgagcccgaa cgctcttcac aaggaacaag ccgttctctt 2652781 tatgaaccat ggcaagcatg tgctttgtga gaagccgttt gcttcgaata caaaagaaac 2652841 agaagagatg atctcagcgg ctaaggcaaa cggcgttgtt ctcatggaag caatgaagac 2652901 cactttcctg ccgaatttca aagaactgaa aaaacacctg cataaaatcg gcactgtccg 2652961 cagatttacc gcaagctact gccagtattc ctcacgatat gacgcgttca gaagcggaac 2653021 tgttttgaat gcgtttcagc ctgagctttc caatgggtca ttaatggata ttggcgtcta 2653081 ttgtatttat ccggctgttg tgttgtttgg cgcgccgaag gatgtaaaag caaacggata 2653141 tgctttatcc tccggagtgg acggagaagg aactgtcatt ctgtcttacg acgggttcga 2653201 agctgttctg atgcattcca aaatctctac ttcctatgcc ccggctgaaa tccagggtga 2653261 agacgggacg attgtaatcg atacgattca ccggcctgaa cgtgttgaaa tccgctaccg 2653321 ggacggccgc cttgaaaaca tcgcgatccc tgatcctaaa ccggcgatgt tctatgaagc 2653381 agaagaattt gtcacgctta taaaagagaa taagctggaa tctgaagaaa atacatttga 2653441 acggtctttg accaccgcaa aaattatgga agaagcaaga aagcaaatgg ggattgtata 2653501 ccctgctgat caagcttaaa aaaatccgcc cgcgtgcaaa tgccgcggcg gattttttat 2653561 tagacaatcg gagaagatgc cttccttttt aaaagcacct gttgctcata ttctttgatg 2653621 tcataaagcc atgcctcttt taccggaacg cccatttgct cacagtagga atcccagatg 2653681 gctccgaaag gatatgtttt gaattcctcc atcagggcca gcctttctgt atagcggccc 2653741 tcttcctgca attgttttaa atatccgttc gggagaagca gggcatacaa taaagctttg 2653801 atcatatttc tcgttccgat ggtccaggcg gctacacggt taatgctggc atcgaaaaaa 2653861 tccagaccga tggctacctt ctcaagagca tgatttcgta caatttcaag agcgatttct 2653921 ctcaattcat catccaaaac cactacatgg tcgctatccc aacgaacagg ccgcgatacg 2653981 tgcaaggcaa gcttgtctgt gtaaagcagc atggacgaga tcttgtttga taccgtctca 2654041 gtcggatgga aatggcctgt atcaagtaaa caaagcttat gattcgtcaa agcataagct 2654101 aaataaaatt catgagatcc gacaacatat gattcggagc caagcccgaa cagcttgctc 2654161 tcgattgaat caagattatg ttgttcactg atctcctctg agaagatccg atccagtgat 2654221 tcttttagtc ttttacgcgg tgtcagccta tcactcggga tatccttata gccgtcggga 2654281 atccaaatat tcgtcaagca aggtgttcct aattctttcc cgaagtattc cccgatacgg 2654341 cggcaagcga tgcaatgcct gatccaaaat tctctgatgt ccggatcagg gtgtgaaagg 2654401 gtgagtccgt cagccgcttt ctcatgcgaa aacaaggttg gattaaaatc taaaccgaga 2654461 ccaaggtttt ttgcccattt cacccagttt tcaaaatgct gcggcttcaa ttcgtcacgt 2654521 tctaccgctt ccctgtttgt ttctgcgtat atcgcatgca ggtttacgcg gtgctttcca 2654581 ggaatgagag aaagagcctt ctccaaatct cttcttaatt cttcaggagt ttgcgctttt 2654641 ccgggataat tgccggtcac gtcaattccg cctgaaagct cgcccttatt tacttcaaag 2654701 ccttcaatgt cgtcaccctg ccagcagtgg atcgaaatgg gcacttgctc taattgccga 2654761 agcgcctctt caacatcaat tccccatttt tcatatgcct gttttgcact gtcataattg 2654821 gcttttatgg tcatacggct ctctcccttt atcagttttt caatccaaat aaaaaacttc 2654881 ctttagatct atcgcaacag gactgaaatc cgaatttgtt ttcattaatg gcgccatcga 2654941 tttccaccat ctttggcaaa cttccgtgtc cgccatcttt ctccatttct cttcatcctc 2655001 tatttctaaa tatgcaaaaa gcctgcctgt ttcctcgtct agaaaaatgg aataatggtg 2655061 tgctccatga gctttgagtg cttctgccat ctcaggccaa atgtcatcat gccgctgttt 2655121 gtattcttcg tacttgtctt gatggacaaa catgatactg gcttttcttt tcaaaccttt 2655181 tcacctcttc atcatttaga tagcgctttc aaaacagttt gctgaaatga ctgaatgatc 2655241 gtgcttctat caatgtcttt aggtgtaaac actttgatcg gaaaggaatt tctgacgact 2655301 tgccgggctt cttttatgtc tttgacttct ttggcagcaa tcatttgcat caaaagattt 2655361 ccggtggcag ttgcctctat cggccctgca tataccgctt ttccactcat gtctgccgtt 2655421 aattgattta agaaatcatt ccgggctccg ccgccgatga tatgaaattg ctcgatcggt 2655481 ttttctgtga ttgtttcgag ctctttgatg gctatcgcat agatgatggc taaattgctg 2655541 tagatgcagc aggcaagttc gcctgcagta cggggaatct tttggcgggt ttgtctgcaa 2655601 taatgttgta tttcctttat catgttttct ggattcagga aacgtttatc atttaagttt 2655661 ataaattgct ggaatggttc tgtttttttg gcttcttctg caagctgctg aaaagaataa 2655721 tctgcttgta gctgctgttt gacttcttgt atcacccaca tgccgataat gtttttgaga 2655781 aagcgaatgg tgttgtttgc gccgcgttca tttgtatagt tgttttctaa agcaagatca 2655841 gttattatcg gtgttttgtt ttcaaccccg attaacgacc atgttccgct gctgatatac 2655901 gcccagccat catttacgcc tggcgccgca atgacggccg aggccgtatc atgtgttgcg 2655961 actgtcatca ccttgcacgc cgggagatca taatccggga accactcatt tcttagcttc 2656021 ccgagttcac accccggttc agtgagcggc gcaaattgct gttccagaac agacacggct 2656081 tcaagcaatt caggatcaag atttcccgtt gagacgttta aaagctgtgt tgtggacacg 2656141 tttgtgattt ccgttacagc ttttccggtt aaacaatagc ctaaataatc aggaatcatc 2656201 ataattttgt ctgtcttttt cagcagctca cggtcttctt caaacaattg atagatcgtg 2656261 ttgaaaggct gaaattgtat tcctgttttt tgataaattg cggcttttga gagggtatgt 2656321 tccagtttgt ctattgtgtg atctgttctt ctatcacggt aggagattgc ttcccgcaac 2656381 cgatcgcctt tttcgtccag taagacataa tcgactgccc atgtatcaat gcctacggtg 2656441 cagtgttcat acccaagcgt ctttactttt tgcagtcctt gcaggatttg ttttagcaaa 2656501 tgatcaatat cccataagca atgcccgtct ctttgactga aaccgttagc gaacctgtga 2656561 atctcttgta tgtcaagctt cccttcattc agttcaccta ccatgattct cccgcttgat 2656621 gcgcctacat caatggcagt ataaatcatc ctttcaccct ctcttcgaaa gaggaacagc 2656681 tgtcaccttc acctttttgt cctcaagagc ttttaccgat gccggatcaa gtccagaatc 2656741 cgtaataagg cggctgacat cttgcagcga ggcgatatgt gaaaactcgc ggttccccca 2656801 tttgcttgaa tcggccatca aaatggtctg gtccgacctt tcgatcatcc gttttttgag 2656861 cagcgcctgc cactcatttg aatcactcat cccgttgtgt acgtcaaatc ccttacatga 2656921 cagaaaggtt ttattgacat gataggtctc aagtgaacgc tctgctaacg ggccggcaaa 2656981 tgataatgat ttttccagca aaatgccgcc tgttgaaatg actgatatgt tttctttatt 2657041 gctgagttca atagctgctt tcattgagtt tgtaatcacg gtgagctcaa tgtcagggag 2657101 tatttttgcc atgtaccaag cggttgtgct tgcatcgaga atgattcggt ctccgctttt 2657161 tacatatttg gccgcttcgt gagcgatggc ttttttttcg atgacattcg tgatttcccg 2657221 ttcagaaaaa tgaatttctg attccttctg ctgaatactg accgctcctc cgtggctccg 2657281 gctcagttta tgttcttttt caagcttttc aagatcacgc cgaatggttt cctctgtgac 2657341 tgaaaaaatg tcacttaatt cggaaacgcg gatgcttgaa cgcatattta ctatttccac 2657401 tattttttgc tgccgttctg ctactagcat cggtaacgcc cttcctcata tcgtagtccg 2657461 tcttatattt ttatcatagc atatatctaa cgcgtaaaag cagcagggac gccgccgtct 2657521 accgtgatca tgcagcccgt tgttttttcg gctttggaag aagcgaagaa tgcaatggct 2657581 tcggcaatat cctccgggta aatattgacg agcaatgctg tccgtttccg gtaatgttcc 2657641 tccagctgat ccggttcaat cccgtacgcc gcggctcgtt cctcacgcca gcttgaaccc 2657701 cagattgccg atccttgaag aactgcatca ggcaaaacgg agttgaccct aatgccgaat 2657761 tctccgcctt ctgctgcgat gcatcttgct aaatgggttt caagcgcctt aacagagctg 2657821 taggcagagg cgttttttcc cgcataaact gaatttttcg atccgacaaa taccatgctt 2657881 ccgcctctat tttgatgttt catctgttta aacgcttcac gggctacaag gaaatagcct 2657941 gttcctaaaa cattcatatt aagattccat tcttttagac ttgtttcgtc aaatgggctt 2658001 gatgtggcca gcccggcatt attgacgacg atatcaatgc cgccgtaagc aagcgccgct 2658061 cgttcaaaag ctgactgtac gtcttcctcc tttgtcacat ccattttgac agccattgcc 2658121 cgtccttttc cgtatgcatc gtttatttcc ccggcaattt tctgtgcgcc ttctatattc 2658181 agatcagcta cgatcacgtg ccctccctca gctgcaaatc ggcggcatgc cgcactgccg 2658241 attccgccgg ctcctccagt tatcagcgct acttttcggg aaaattctgc ttccggcggg 2658301 gccagcgtga gtttatatag ttcgagcggc caatattcga catggtagga ctcattttca 2658361 tgtaaagaaa caaattgccc cagagcggtt gctcctttca ttacggcgat ggccctccga 2658421 tataaagccc cgcttacttt agacatcgca taactttttc ctgtattcac cattccgatt 2658481 ccaggaatca atatcacccg cggggcggat tcaaagattt gatccccatc ctgctgattg 2658541 cgtgtaaagt aagcctgata ctctgatgta aaggtctcga ctcctgactt gatcagatct 2658601 gcaagcttgt gcacatcttg agtttccgga ttccaatcaa tgtacagcgg aacccgtttt 2658661 gtgtgaacaa ggtgatccgg gcatgccgca ccgatttgcg aaagtgctgg cgcttggaca 2658721 ctgtttacaa attccaagac atcgtcatga tcatcatagg aaaggatcat tttcttttct 2658781 tcacttactg ctcctctgat cacaggcatg atgcctgcca agatttgttt tcttttatcc 2658841 tccggcagcg gctgatacct tttgcctccg aatacctcat gctgattgat acgatcgtta 2658901 atatactgct cggcttcttg aatgatggat atcgtttttt gataacatgt ttcagacgtc 2658961 tctccccaag tgactaagcc gtgtttctcc attaatacaa gctcggcgtg ggggttgttt 2659021 gctacgcctt cagcgatcat tttagacaaa gtaaatccag gacggacgta tggcacccat 2659081 acaaaccgat ttccgtaaat gtcttcagcg atttgttttc cattatccgc acagcatatg 2659141 ctgataatcg catctggatg ggtatggtca acatgtttgt atggcagaaa agcgtgtaat 2659201 agcgtttcaa ttgaagggcg gggatgtttg ctgtctatca tacaatgaga caggtagtct 2659261 accatttctt catcgggcat ttggtccctt ttaatcagcg ggcggatatc atctaatttc 2659321 aaaccggaaa agttatgcgc tttcattgtt gccaaatccg atccgcttcc ttttacccac 2659381 atgacttcta tttcacggcc tctaaaatcc ttttccgttg ttttcataga tgtattcccc 2659441 ccgccccagt tgcagacagt gcggtctgac ccgatcagat tggacctgta caccaattcc 2659501 tctacacctt taggtagctg tgcagctcgc tctgaatccc atatatgttt caccatattt 2659561 gatattcctc catacccttt tatttgtatc cgttttcatt atatatgatt tctgtttgtt 2659621 tttgaatcgt ttttgtttat ttttgctttt taacaaaaaa agaaagcagc agatatgccg 2659681 ctttctcgtt tcattatgat tctattttaa atttcttcgt aatgtcctga agttcttccg 2659741 ccatgtttgc caacgtttcc gctgaagagc tgatttcttc catggacgca agctgttctt 2659801 ccgccgaagc tgcgatatcc tgaatgcctg ctgagctttc tttcgccact gcagaaatat 2659861 cttcaacagc acttgacact tcctgtgatc cggctgacag ttgttcaacc gtcgcgttca 2659921 agttttgcaa ttcgccggaa atttgggttg tcatctcata gatttgttta aagctttccg 2659981 ctgtttgatc cgtaatctgc aagccttctt tcacttcatg attcacggat tggaacattg 2660041 aaagtgaggt gctgatttcc ctgacaatct cttgaattaa tccttcaatt tccttggcgg 2660101 agtctgctga ttgtacagca agttttctaa cctcttccgc aactactgag aaacctcttc 2660161 cgtattctcc cgctcttgcc gcctcaatcg cagcatttaa tgcaagcagg ttggtttgat 2660221 cagcaatgcc gttaatcaca ttcaagatgc ttgtgatgtc ttgcgatttt gtttcaaggc 2660281 ccttcacaac cgcttccgct ttttgaacgg attggtcaat tgttttcatc tggccgactg 2660341 tatgctccac cagcttttct ccgctgcccg ctgcctcaga ggactgaatc gatgatttcg 2660401 taatggttga agaggcttga gccacttttg aaatcccctc gttcatttga gaaagatgat 2660461 ttgagcttgt ttccagtttc tcgctttgtg cctcgttgcc atctgagaac tgttcgatgg 2660521 caagtgtaat atgttcagtt gccttgcttg tttgggctgc gcttgctgtc agctcctcag 2660581 aagatgaagc gacgttttct acagacgttt gaataacgcc tattacagaa cgcaatgatg 2660641 cagacatttc attaaagctt tcgccaagct ggccaaactc gtttttcgag tgaatgtcaa 2660701 tgacttctgt gagatctccg ctgctgattt ttgcagacgt tgagacaagt tttcttaacg 2660761 gcttggtgat ggcacggata atatagagta tgagtatgcc gccgattact attgacacgc 2660821 atagaatgat aaccgcagtg ttcagcaccg ggcttgaagc atcttgcaat tcactgacaa 2660881 aatatgtgcc cgcgattttc cagccagtca gtttatttgt cgtaaaggcc attttctttt 2660941 ctttgccttc gaatgtatat tcaaatgagc cttctttttt ggaatatact tggtttgtcc 2661001 aatcgccgga accggttgtc cccggcttaa tggtcggatg ggcgatatat tttttgttgc 2661061 ctgtcgtaat aaatgcaaag ccttcttttc cgattttgat tctttttgat gcagtaagca 2661121 cttcatccag gtttaaatct agcgctataa cccctgaacc gtcttttaat tgttttgaaa 2661181 ttgtgacaac gatatctcct gtcgcttcat cggtatacgg ttctgagaaa acagcttgtc 2661241 ctttttccgc aaccgcctgt ttgtaccagt cacgtcctgt cggatcgaaa cctttcggaa 2661301 caccgctatc cggatattta taaagcttct tatcttctga ggcagcatag attgcgccta 2661361 catcgtcgtt aagtgtcgtg tactgcttaa atttctcttt cagtaatgtt ttgtttttgc 2661421 ctaacaatat gtctttatcg actgtctcac tataataatc tattgctttt actttatctt 2661481 ctaatttatt ttgcagcgta ctgtttagtt cttcaacatt tcccttcgca ctgcttatga 2661541 gctctctgtc taacgcgttc caagctgatt gataactgaa atatgctaaa accccaaccg 2661601 gcaaaataag cactgccaga aacgcagcga ttagcggttt gctgatcgat ggctgtttga 2661661 tccattgtat gaattttccc attctcgttg actcctcctt taagataaat ctaatatcgt 2661721 caaactagga taaaaggttt aataaaaaaa ctaaaaaaaa cacccaagcg caacaagctt 2661781 gggtgttaag gcttattatt caattttaaa tcgtttggtc atatcccgaa gctcttccgc 2661841 catagaggaa agggtctctg cagacgagct gatttcttcc atggaagcta gctgctcttc 2661901 agctgacgcc gcgatatctt gtatatgcgc tgagctttct tttgaaatcg atgcaatgtg 2661961 ctcagacgct cccgaaactt cttcggagct ggcagaaagc tgctgaaccg tcgcactcat 2662021 attttgcagt tcgccggcga tttggttcgt catttcagaa atgcgtttga agctcatttc 2662081 tgttttatct gtgatgtcaa gtcctgtctg cacctcttga ttgacagatt ggaacatgcc 2662141 gagtgatgta ttgatttcct tcacaatttc gatgattaat ccttcaatct cttttgctga 2662201 atctgctgac tgtactgcca gttttcttac ttcttccgct acaacggaga agccgcggcc 2662261 gtactcgcct gcgcgcgctg cttcaattgc tgcgtttaag gcaagcaggt tcgtctggtc 2662321 tgcgatgccg ttgatcacac gcaaaatgtt tgtaatatct ttcgatttcg tttccaatcc 2662381 gcgtacgact tgctccgctt ctttaacgga cttgtcaatg acattcattt ggccgacggt 2662441 ttgatgaaca agcttgccgc cttcacttgc aatttctgtc gattgaacag atgaatcagt 2662501 gatcacttca gaagcttgag ccatattcgt caacccgtca ttcatttgat aaatgtgctc 2662561 tgctgccgtt tcaatgtttt cgttttgttt ttcattgccg ttagaaaatt gttcaatcgc 2662621 caatgtaatg tgctctgttg ccttgctcgt ttgcgcagct gatgcagtca gctcctcaga 2662681 ggaagcggca acattgtcta ccgaatcctg gatggcgtgt atgagagaac gaagtgacga 2662741 cgccatattg ttaaagcttt tgccgagctc gcccaattca tcttttgaac ggatatcaat 2662801 ggtttccgtc aaatctccct cgctgatccg cttagaggaa ccgacaagct gtttcagcgg 2662861 tgttgtaatc gaccgaatga tcaatgtcat gacgataatc cctatgataa tagctgcggc 2662921 caagacaatt aaagcaaggt gaaggacagg ctgggctgcc tcatggattt catccaaata 2662981 catggtgccg ccgatcttcc atcccgtcaa cttgtttgtg tcaaaggcca tttttttctt 2663041 atcgccatcc atggtgtatt gaaaatcgcc tttatcagca ctcaacatct tatcgagcca 2663101 gtcgcctttt aattcagttc ctgattgttc attagggtgt gcgacaactt ttttgtcctt 2663161 cgtcatgata aatgcgtagc cttgtgtgcc gatgttgact tttttggttg ttttcagcag 2663221 attttcaatc gtcatgttga ttgcgataac gcctgaacca tcttttgtct gctgggcgat 2663281 tgtcacaacc atcgtatttg tcgacgcggt tttataaggg tctgtgatca cgactttccc 2663341 tttatttgca accgcttttt tgtaccagtc gcgttcaacc ggattatagc cgcttggcat 2663401 cggaagatcc ggatagcggg taaagtgccc ttttgtgtca cttgtataaa tggattctac 2663461 atccttgtta atgctgatat attgtgagaa tttctctgca atgcttgcat tgctttttgc 2663521 attgtatttc tcttttgtca gccattcgct gaaataatca gcactgtttt ctttttcgcc 2663581 gatgctggtg ttaatgattt cgtttaattg ctgtacattt tccaatgcgc tccccatcat 2663641 ctgtctgtcg agtgagctgc tagccgattg atacgcaaag atcgccaata tgacaaccgg 2663701 tatgatgagg atcgacagaa aggaaacgag aagcttccgt gtaattgatc tttgttttat 2663761 gagttggagt atttttttca tcattcattt ctcctttttt atgctaccct tcatatcggc 2663821 tggaaatggg taaatatata cagcaaaaaa gaagaaattt aacaaaagta actaatttcc 2663881 cataaataaa tagtatttta gacctattat ttgtctactt taaattgttt tgtcagatca 2663941 cggagttctt cagacattct ttcaagcgtc agtgcagatg aactaatctc ctccatggat 2664001 gccagctgtt cctcagctga agcggcgata tcttggatgc catccgagct ttccttagaa 2664061 atggcagtga tatcatttga agctgcggaa atttcttgag ctcccgctga cagctcctca 2664121 accgtcgcat tcatgttttg cagctcggaa gcaatttgat tggtcatttg cgatatatgt 2664181 ttgaagctct gtttagtttc atccgtcatg acaagccctg tttcaacttc tttgtttacg 2664241 gactgaagca cgttcagtga tgtgtgaatt tcttttacta tttcactgat cagcgattca 2664301 atttcttttg ctgagtcagc cgactgtacc gcgagctttc tcacttcctc agcgacgact 2664361 gagaagcccc ggccgtattc acccgctctg gcagcttcaa tggcggcatt taaagccaaa 2664421 agattggttt gatccgcaat gccgttgatg acacgcaaaa tattcgtgat atcctttgat 2664481 ttgatctcca gccctttcac cacttgttcc gctgctttta cggaatggtc aattgtgttc 2664541 atttggccgg ctgttttctg gacgagtgtc tcccctttgc ttgacacttc ggttgaatct 2664601 gcggatgttt ctgtaatcac tgctgcagcc cgcgccagct ctgccaatcc gtcattcatt 2664661 tcattaattt gttcggttgt cgtttctatt ttctcgcttt ggctttcact gccgtttgaa 2664721 aattgctcga tagccatcgt aatgtgctca gtggctctgc ttgtctggtc tgccgatgca 2664781 gtcagctctt cagacgagga ggcaacgtgt tctactgagt ctttgatccc gtgaatgagc 2664841 gagcgaagcg agtgtgccat atgattgaag ctctcactca gaacgccgag ttcatctttt 2664901 gaattgattt caatcgtttc ggttagatcg ccttcactaa ttttttcagc ggatgcgaca 2664961 atgcgtctca atggctttgt gatggatcga atcacaaaat aaatcgccgt cattccagct 2665021 ccgatggcaa tcgccagaac gattgaagcc atgatcagaa ccctgcttgc agcatcgtga 2665081 atctcgtttg catacatcgt gccgctgatt ttccagcctg ttgtttggct tgttgcaaat 2665141 gccatttttt tctttttgcc tttgtacgta tattcaaagt ccccgctttt atccttgtag 2665201 agcttatcaa cccagtcccc ttttagctct gttcccgctt tttctccgga gtaggcgatg 2665261 actttcttgt tttggctcaa aataaaagca tagccttctt ttccgatatt gattcctttc 2665321 gcggtagtga ctaagtcatc aattttcata tcaatggcga caacgcctga cccatccacc 2665381 gtttgacggg cgatggtgac gaccattttt cctgatgaaa tcgattcata aggctcagtg 2665441 acaattgttt tgcctttatt ggccattgct tctttgtacc aatctcgttc caaagcatta 2665501 aagtcgcttg gcatgtcagc gtacggataa cgtgtgaagt ccccgtcttt gccgcttgaa 2665561 aataccgcag cgacattatc attcatttgg ataaattgtt taaattcctg tttcagctct 2665621 gttttctttt tatcctgaaa tttttctgct gtagcccaat cgctgaaata tgcgaggctt 2665681 ttttcagtag tgctgatttt atcatcaatg atgtgatcta atatctgaac attttccttt 2665741 gcgctttgcg tcatctgtac atcaagtgag gcaactgctg attgataagc gctaaccgaa 2665801 agggcggtta tcggaacaat taagatcagc aggaaagaaa taataagtct ccttgcaatt 2665861 gatgatctgc gaatagtggt gagtgttttt ttcatttcct tttgaacctt ctttcaataa 2665921 tttacaaatt atatcggcgg atcttccttt aaattacatt gaaaatggag gaaaaaatga 2665981 aaaatagttc taaattcacc tgttaaacta ggactttatt attgtttacc atataaaaaa 2666041 acagcgcttt gatagcgctg tttttcggtt tttactcgat tttaaattgt ttcgtcagat 2666101 cgcgaagctc ttctgccatc tgcgcaagag tcgtcgctga ggaactgatt tcttccatgg 2666161 aagcaagctg ttcttcagct gatgcggcaa tgtcctggat gcttgccgag ctttctttcg 2666221 acacgtctgc aatgccgctg actgctgctg aaacatgctg tgaacggtct gacagctgct 2666281 cgacggtgga attcatcgtc tgcagcttgc ccgcgatttc gtttgtcatg ctgaaaatgc 2666341 tctggaagct ttcttttgta ttgtctgtga caacaagtcc ggactgtact tcctgattga 2666401 cctctttaaa catgtgaaga gaggtgtcga tttctgcgac gatttcttgg atcagctttt 2666461 cgatttcttt cgctgaatcg gctgattgga cagccagctt gcgcacctcc tccgctacga 2666521 cagagaagcc gcgtcctgac tctccggcac gcgccgcttc aatggctgca tttagtgcaa 2666581 gcagatttgt ttggtcagcg attccgttga tgactctcaa aatgcttgtg atgtcttttg 2666641 attttccttc taagcctttg acaacagctt cagcctgctg aacagattga ttaatcgagt 2666701 tcatttgtcc gactgtctgc tgcacaaact tctcacccgt tccggcgatt tccgttgatt 2666761 ggatagatgc ctttgtaata tctgacgatg tttgtgagac ttgctggagt ccttcattca 2666821 ttaagttcag ctgatgagag ctggattcaa ccttttcgct ttgctcctcg tttccgtttg 2666881 agaactgctc aatcgccatc gtaatatgct cggtggcttt actcgtctgc ccggcagatg 2666941 cggtaagctg ttcggaagat gcggccacat tgttcaccga gtcctgaata gcgctgatca 2667001 gagagcggag agattgtccc atttcattga agctttcccc aagctctcca agctcatcct 2667061 ttgaatggat ttcgatcgtt tcggtcagat cccccctgct gatcgttttc gatgattgaa 2667121 caagacgttt taacggtttt gtaatcgaac gaacgataaa cagaattaaa attccgcctg 2667181 ccacaatgga agcaatcagc acaatcattc ctgttgtcag cacagacttt gaggcatcct 2667241 taatttcatc catatacatt gtgccggcta ttttccaacc agtcagttcg tttgtagtat 2667301 aggtcatctt tttatcttcg ttattaagag tatactggag ttcaccgctg tcattcgcat 2667361 acattttggc tacccagtcg cctgaaagct tttctccagc cttatggttc ttgtgggcga 2667421 cataggtttt gttttttgtt gcaatgaaag cataaccttc ttttccgacc ttgatttgtt 2667481 tcatttgttc taacaattta tcaatggtaa tatccatggc gacaacgcca gatccgtcct 2667541 tcagctcctg tgcaatggta atgaccatgc ttccgtcact cgcagccacg taaggatctg 2667601 tcacgacaat ttcaccgccg gccttcatcg catcctggta ccaaggccgt tgtctcgggt 2667661 cgtatccttc cggcaatttt tcttttggcg cttgtacata agtgccgtta tctgcgcccc 2667721 cataaattct ggctactcct tgattaatag atacatattg tgaaaattta gctttgatct 2667781 cttcttgatt tgatttccct ttgaatgcgg atcttttaag agattcactg aaaaaggtga 2667841 ctgctttcgc tttttctccc agatcatttg taacagttgt attaaatgta tcgacactgt 2667901 ttttcgcatt tcccataatt tcctgatcca gctttccgct ggcgcttcgg taagagctaa 2667961 attctaatat aagaataggg ataatgagaa tcgcaataaa tgagacgatt aatttctttg 2668021 aaatagacgg tttcttcagc caattgataa aagtcttcat gtcacttgct ccttcaggtt 2668081 tgatacagta tatatcggct gcttaaaaaa gttttaaaat aaaaaatgga agaagttctt 2668141 tttggctgtc ttctgccttt ttaactttca ttgcccaagc tctttgcata tcttataaaa 2668201 aacaaggggg gctaaacatg attattgtat caggacaatt gctccgtccc caggatattg 2668261 aaaattggca gattgatcaa gatctgaatc cgctcttaaa agagatgatt gagacgcctg 2668321 ttcagtttga ttatcattca attgctgaac tgatgtttga gcttaaactg cggatgaata 2668381 ttgtagcagc ggcaaagacg ctgcacaaaa gcggggcgaa gtttgccact tttttaaaaa 2668441 catacgggaa tacaacgtat tggagggttt caccggaggg cgccttggag ctgaaataca 2668501 gaatgccgcc ttcaaaagcg attcgggaca ttgcagagaa cggcccgttt tatgcgtttg 2668561 aatgcgcaac cgcaatcgtt atcatttatt acttggcctt aatcgataca atcggagaag 2668621 ataaattcaa tgccagcttt gacagaatta ttttatatga ctggcattat gagaaattgc 2668681 cgatatatac ggaaacagga caccactttt tccttggaga ttgtttgtat tttaagaatc 2668741 ctgaatttga tccgcaaaag gcgcaatgga gaggcgaaaa tgtgatacta ctgggggaag 2668801 ataaatattt tgcccatggt cttggaatct taaacggaaa gcaaattatt gataagctga 2668861 attcttttag gaaaaaagga gccttacagt cagcctacct tctgtctcag gcgaccagac 2668921 tggatgttcc gtctcttttc cgcatcgtcc gctaaaaagc cccatcgcct attttccgga 2668981 cgatggggtt tcaaatgcct ttcgttttcg atagaagggg gctgtgccaa aatattggtt 2669041 cgcagcccac tccatttttt caaggtcatt tcttgtcacg attggatcct ggctgctcca 2669101 tttgataaag cggacaaaat agtagccttt gataggaacc attgtaactt ttgagtgagg 2669161 ccagccttca aatacaaact caattttccc tcttttttta taagaatatt gaagaatgtt 2669221 catatctgtc acctcagttt atcaagttac gttcggcaaa gctcggtacg tttacatcca 2669281 ttgattaact atccctcatg caggctttcc ggaaaacaaa gggtgaggcg cgtgtctctt 2669341 tccctcgctt tttatttcgc atatggacga atgccaagca cgccttcatt cgataaagcc 2669401 gcagcgtggg cgggtgtgac aagccctccg gctatcggcg cttgttcagc gatcatgctt 2669461 ttgtcataaa aaacagccta ttatcccatc attttgatat agcatgtccg ggtgcgaggc 2669521 ccgtcaaatt cgcagaaata aatgccctgc cacgttccaa gaataagccg gccgttttcc 2669581 acaatgacat gctgtgaagc tccgaccgta ctcgacttca tgtgtgcagc tgtattgccc 2669641 tccatatggc ggtccagctc atgttcccac ggatatacct catcaaacct tctgagcata 2669701 tcttttttga cgtccggatc ggcattttca ttaattgtaa tgcccgcagt cgtatgcgga 2669761 cagtaaatca gcgctgcgcc gctcgttata cctgtttctt gaagaaacgc ttccacctcc 2669821 cgggtgatat ctatcatttc atctcgtttg gttgttttga tttgcagtgt tttcagcatt 2669881 tgtttctcct ttcgtttgtc cgctctcatc gcttaattcg ttctgtgttc ttttttttcc 2669941 tgttaaaccg ctctcataaa cccgataaaa caaaaaaact ccagtctaag gctggagttt 2670001 agcaccatag atatattctt gcttcatacg gctttaagag tactgatgtc atatgcttgt 2670061 gcggctctgt ttcaatattt gacaagacga gtgcatctga tgacaatggc aatccagagt 2670121 gcctgaacaa cgccggtgtt cctgtcagat tggccgcaat cagtgcagta tggctctcgt 2670181 ttttccgaag atatgcaaag atttgctgat cttccggtaa aatgagctcg tatgtcccgt 2670241 taataaaaac atcatatgtt tggcgcagct tgatcaagct tttgtaaaaa tggtaaacgg 2670301 atgttttatc gtttttttgc gcctcggcat tcagccattt gtaattctca ttgattccga 2670361 tccacggttt ggcctcagaa aatccggcgt atggaccagc attccattgc atcggcgttc 2670421 gcgaattgtc tcttcccttt ttccagacaa tcttcatcac atcctcgtgt gatgtgcctt 2670481 tcgctgtttt tgtttcatac aggcgtttca atgcgacatc atcatagtcc tcaatagatg 2670541 gaaaagccac gttcgtcatc ccgagttcct gtccctgata aataaacggt gtgcctttca 2670601 tgagaaaata aacagcggaa agcgcttttg cactttcttt caggtacact ccgtcgtctc 2670661 cccacacaga aactgaacgg ggctggtcgt gattctccat aaacaaagca ttccagccga 2670721 tcccttccag actgtcctgc cagtcagtta aaattcgttt aaatgcaacg atatcaatac 2670781 tttcattgat ctctacatcc cacaggccga gatgctcaaa ttgaaaaatc atgctgaata 2670841 tgccgttttt ttctccagcc caatcagctg cttcttttgc agcgacgccg tttgcttcac 2670901 caactgtcat aatcggatag cgggaaaatg tgttttcctt cagctctgtt aacaaatcca 2670961 taatgccgtc agcattcata tgataaggaa aggaagggac atagtccagt ccctttggat 2671021 tcggcatgtc aggaaaccct tcttttttct taatatgcgt aatggcatcc acccgaaatc 2671081 cgtcaattcc tttatcaagc caccaattga tcatgtcata aacggcattc ctcacctttt 2671141 cattttccca attcaaatca ggctgttttt tatcaaaaag gtgcagataa tactggcttg 2671201 tcttttgatc atactcccaa gccggcccgc cgaaaatgct ttcccaattg ttgggcgttt 2671261 ttccgttttt gccgtctttc caaatatacc agtcgcgctt ttccgagtgt atggatgaac 2671321 gggattctat gaaccatgga tgttcgtcgc ttgtgtggtt cacaacgaga tccataatca 2671381 gcttcatatc cagatcatga atgtcaccaa gcagctcatc aaaatcttcc atcgtgccaa 2671441 actcgcttaa tatgttttga taatccctga tatcatagcc attatcggca ttcggtgaat 2671501 catacagcgg gcaaatccat atgacgtcag cgcccagctc ttttatgtaa gaaagcttgg 2671561 ttctgattcc ttgaatatcc ccgattccgt cgccatttga atctttaaaa ctgcgggggt 2671621 aaatttggta aactacggct tccttccacc aagccttttt catacagcca ctccttccca 2671681 gtgtaccgtt cttatatatc ctatgtagaa aaaggtcttt acagcattgc tttttaagaa 2671741 atgacttgat gacacaaaaa acagccgttt gttccccggc tgttttttat caaaaatcag 2671801 ttttttttat ttctacaaaa cggatgtggt gatcttcggc gtcgaggatt ttaaattcac 2671861 agccctccgc gtgtatcaca tcccctgctt tcagctccat tttttgcgtt agaagccagc 2671921 ctgcaatcgt atcaatttct tcattttcaa tcgcaatgtc gagaaggtca ttcacttcgt 2671981 ctattagcgc ttttccatcc atcacataat ggtgctcgcc ctttttcagg atgtgcggtg 2672041 tttcatcctg atcatactca tcgcggattt ccccgacgat ttcctcgata atatcctcta 2672101 cagtgacaag ccccgccgtt cccccgtatt catcgacaag aatcgccatg tgaatccgct 2672161 ccttctgcat gcggattaaa agctgctgaa caggaatgct ttcaatgact ctgataacgg 2672221 gcctcatgat ttgattcagc tttatcggct ggccgagaaa ataagcttta aacatatctt 2672281 tgctgttgat gatccctaaa atatgatcct tgtcatcttt gatgacaggg tagcgtgtat 2672341 accgttcatt aatgatgtga tgaattgcct cttcaagcga ctgctccaga gagataaccg 2672401 caatttctgt ccgcggaatc ataatctctc tcgctacccg gttgtcaaat tcaaaaatct 2672461 tatttacata gcggaattca gactgattga tttctccctt ttcatagctt tcagaaagga 2672521 tcagccttag ttcctcttcg ctgatgacaa cctgatgctc ctttaccgaa tgaaagccaa 2672581 acaatttcac aagaaaactt gcagagccgt ttaatgcttt aataaacggg tacgtgattt 2672641 tataaaacca gatcagcggc tttgcaatcc ataagcttac agcttcagct ttttgaatag 2672701 aaaccgtttt cggggcaagc tcccccatca ccacatgcaa aaaagtgacg atgataaatg 2672761 caactacaaa tgtgacaatg tggttaaacg gttccggtat gcctgtcatt gtaaataagg 2672821 gatgaagaaa acgttcaaat gtaggttcac caagccaccc aaggccgagg gctgtaatcg 2672881 taatcccgag ctggcaggct gataaatact cgtcaagatt ggagatgatt ttatgtgcgg 2672941 ctagtgctcg gctgtcaccg ctttcgatga gctgattgat ttttgaacct ctgattttga 2673001 cgatcgcaaa ttccgctgca acgaaaacag ccgtaatgcc aatcaaaaca aaaatggcga 2673061 tcaattgtaa aataagcaaa aaaagccctt accataaatg gtaaggggcc acctccttaa 2673121 cgttaattct catcacgacc gtttaagaaa atcatcacaa aacgaagtag ttcaaacagg 2673181 gaaaccaggg cggcggccac atacgttaag gcagcagcac tcagcacttt atttacccca 2673241 ttttcttcat tgtttcggat gaatccttct gacacaataa tctgcttcgc acgtgaactt 2673301 gcattgaatt cgacaggcaa tgtaatcagc tggaaaaaga cagccgctga aaacagtatg 2673361 atgccaagcc cgatcaaatt caggctgccg agaagcatgc ctcctaagaa aagcaaagga 2673421 gctacaccgg atgcaaaatt cacgactggg aagattttat gtctcagcac aagcgcacca 2673481 tatgactcct gatgctgcaa ggcatgtccg acttcatggg aagctacgga tatggcggaa 2673541 attgagcggc cgtaatagac cggctcagat aaacgcacca cccgtcttgt cgggtcgtaa 2673601 tggtctgtta aagtgcctct taccggttcg accggcacgt cgtaaagacc gtttatatct 2673661 aaaatccgtc ttgccgtttc tgcccctgta cgtccgcttg aggcttccac ttttgaatat 2673721 ttttcaaagt tgctctttac tttaaattgt gcccaaaacg acaatcccaa tgcggctatt 2673781 gttaaaaata taaacagcat tttttcatca tcctttgttc atgatcattt ctctattacg 2673841 attattttaa tgagttttct ttctcgtgta cagaaatgcg ctttttcttc cggcttggag 2673901 cacacaatcc aatcagcaaa aagaacaggc ctgctgaaaa caaataaaag gcgaaactgc 2673961 cggccagttc tttcagaaaa tgaagccagg agaagcttcc ggaaaagtga ttatatgaat 2674021 tcaaatcgaa aataaacaaa atcaccgcgg atgccgccag ctgcgtaccg attaaaacca 2674081 cgatcgttct ttgaaagatc gtcatctttt tcatcctttt tgttttagtt tatggagaaa 2674141 tccggtttta tatgttttgt acattttttg aaaaacatca ccggaagtgg gacatactgt 2674201 tagaaaaaag cacgggtgtg atggaagcta tgaaagtgac gagtgaggaa aaggaacagc 2674261 tgagcacagc aatcgaccga atgaatgaag gactggacgc gtttatccag ctgtataatg 2674321 aatcggaaat tgatgaaccg cttattcagc ttgatgatga tacagccgag ttaatgaagc 2674381 aggcccgaga tatgtacggc caggaaaagc taaatgagaa attaaataca attattaaac 2674441 agattttatc catctcagta tctgaagaag gagaaaaaga atgaaatcaa atcggatatt 2674501 tatttcatgg ctcaggtggc cgttatttat ccgaatcggg gttattattt tatgtctgat 2674561 tcttttgttc ggccaaatca tttatatact tgagcctaag cagttcactt cggtattcga 2674621 aggtatttgg tgggctgtcg ttacggtttc tacagtcggt tatggagact atgtgccgca 2674681 cactccgctg ggacaggcag ccggaatact gctgattttg agcggagcaa gctttgtcac 2674741 agcgtatttc gctacgttat cagcggccgc attcagcaga cagcatcgct acattgaagg 2674801 aaaagttgct tacaaaggcc gggaccacat cattctgatc gggtggaatg aaaaaacaaa 2674861 ccggcttttg aaggaccttc agcttgccgc cccttccaaa acagtcgtac taatcgatga 2674921 atccttaaca gaaggcccgc ttattgaaaa cgttcatttc atacgcgggc acgctgccga 2674981 tgatgggaca ctgaaacggg ccaatattac tgaagcggaa tcagtgatga ttactgccga 2675041 tcagtataaa agtgaaactg atgctgatat gctgtcagtg ctgactcttt tatctgttaa 2675101 aggtcttaat ccccttgctt actgcatcgt cgagatttta actgaccgtt ttgtcaccaa 2675161 tgcggaacgg gcaggcgcaa accaaatcat cggaacttca gaatttatca gccgggcgat 2675221 gctgcagcat taccaagtca agttacggcc gtctaaacag cagaacggaa tcaagctgac 2675281 acttgatcag catgtggagc ttcttgctgt tcctgacgaa ctaaagggag cggcttacaa 2675341 aacctgtgtt ctctatttcc ttgatcacaa cacaacaatt ataggcatac aaaaaaagga 2675401 ggggccgatg ctttcccctc ctcttacata caaggtgctc gaaacagatc aattccttgc 2675461 catctagtgt aacagaacat cctccaattc tttcacgaga gaggcgccga tatccaaaaa 2675521 tgccggatca atttccgcgt cccgcctttc cggttcggaa aattgattaa acagtgattg 2675581 gaaaggccct ccctcggcgt gatcgtcaac atccgcctga aacacctgtc tcagcataaa 2675641 tggcgttccg atccggacgg ccgcccctcg ttcatcgaga ctgccctgta ccgcattgac 2675701 gggaattctt aaaaataaat agccgtctct atcatcaatt ttataatcaa agtagccatg 2675761 atcgtattcc cagccgccgt ttatcacata accgagcggc ttcatcactt gttccagttc 2675821 ttgaagcaga aaagactgcc catctatcgc ggaaggtatt ggtatcatca gaatgcccct 2675881 tttttcactt atcctgtccc gccgaacaag acttcattca gaggcgccta catggaaatc 2675941 gttgtttctt tcgcgcggcc aacaggaaag aaagcgcatt caattaagaa gtaaacagcc 2676001 attgccgctg caagccatac agctgaatcc caagacacat aaacaaccgt tgcatagagt 2676061 cctaatttag tgaaaagagt atgggttcgt tttaaatgca aaatccgatg taccgcatcg 2676121 gtaaaaaggg caagcggcaa accaatgaga agaaaggagt ggatgaaaaa atgtgacagc 2676181 gtgccgccaa agcttgaaga aaaccctgta tacacggcat caaaggagat aaggaaactt 2676241 aaaatagctg cagaaaaacc ggcaatgatg agatgtttaa ccaattgttt catgaacatc 2676301 agcacctttc tgattttata aaaagccgac cggcaaatgc cagtcagctt tctcacatta 2676361 atcttccaga cgtttttcaa gctctgcttt tttctcttca aagccaggtt tgccgagtaa 2676421 cgcaaacata ttgactttat acgcttctac accaggctgg tcaaacggat tgacgccaag 2676481 gaggtaaccg ctcatcgcgc aggctttttc gaagaaatat acaaggtatc caaaagtata 2676541 tgcattcagc tcaggaatgt taacgattaa gttcggaaca tttccgtctg tatgggcaag 2676601 cattgtacct tggaatgctt ttttgttaac gaaatcaaca gttttaccgg ctaaatagtt 2676661 caagccgtca agatcgttat ccgcttcctc aattgtcagt tcatgtttag gcttctctac 2676721 gttcaggacc gtttcgaata aatctctgcg gccttcttgt acatactggc ctaaagaatg 2676781 aaggtctgtt gaatagttcg ctgaagaagg ataaatgccc ttctcatctt tcccttcgct 2676841 ttctccgaac agctgcttcc accattccgc aaagtattga agcgccggtt cgtagttgat 2676901 gagcatttca attgttttgc ccttattata aaggacattg cgaacaaccg catattggta 2676961 tgctgggtta tcttccagtt cagatgttgc aaaatctttg ctcgcatcca gggcgccttt 2677021 catcatgtcg tcaatgttga cgccgctgac agcaatcggc aagagaccta cagctgttaa 2677081 aactgaataa cggccgccga catcgtcagg aattacgaat gattcaaagc cttcttcgtt 2677141 agaaagcgtt tttaatgcgc cgcgctcttt atcagttgtt gcataaatcc gcgctttcgc 2677201 ttcttcttta ccgtatttct cttcaagaag cttgcggaaa atacggaaag cgattgcagg 2677261 ttcagttgtc gtacctgatt tagaaatcac attaatagag aagtcaacat cttcaagaag 2677321 atccatgacg tctctcatat aagatgaact gatgttgttc ccgataaaaa tgacttgcgg 2677381 attgccgcgt tttgcttttg gcaaagtgtt ataaaacgcg tgattcagcg cttcaatcgc 2677441 tgcccgcgct ccaagataag aaccgccgat gccgacaaca agcaagacat cagagtcaga 2677501 tttgattttt tccgcgcttt ttttgatgcg cgcgaattct tctttatcat aatgttcagg 2677561 gaggtccacc cagcctagaa aatcgctgcc cgcgcctgtt ttctcatgga tattatggtg 2677621 tgctgttttt acaaagtccc gcaggtatgt aagttcatgt tcgttgaaga aagtcaacgc 2677681 ttttgagtag tcaaagcgta catgcgtcat tgcttgtccc tccataacgg tataatgttt 2677741 tcatctttca ctttatatga acttatctgt gaaatcaagt caagaagaaa gggcggaatg 2677801 actggattcc gccctttggg tttatagaga cgcgcgaagg atggcaagca cgtcatcttt 2677861 gttcagtttt tggaagttgc cgaagccgcc gtgttccatt tccttggctg cgatatcagc 2677921 aatcagctca agcttttctt ctccaatatt gtaatcagca agacgagaag gtgcaccgag 2677981 gcttgtccag aacgcagaca gtttatcgat tccttcaagc gcaatttctt tatctgtttt 2678041 gccttcagta tcaatgtcaa acatgttgag cataaggttt ttaaaacggc ctacatttgt 2678101 atcaagcgtg tatctcatcc aatttgggaa cagtattgcc aaaccgcccg cgtgcggaat 2678161 atcatataca gctgaaacag cgtgttccat tgtatgagaa gcccagtcac cgaagtatcc 2678221 catttggagc gtgccgttta aagcaatagt accagcatac aaaatcgttt cacgaagttc 2678281 gtagttttcc agatcttcaa gaagcttagg agctgtttcg atgaccgtct gcaaaacagc 2678341 aaagcacatt ctatcctgaa gcggcgtgtt ttcaacatta tggaagtatt gttcgaatac 2678401 gtggctcatc atgtcaacca tgccgtatac tgtttgattt tctggaacgg tgaacgtatt 2678461 ttcagggtct aaaatagaga aacgcggatg agtgacattg ctgccccata caaatttctc 2678521 gtttgtttcc cagtttgtaa tcacggaatc agggttcatt tcagaccctg ttgcagcaag 2678581 agttaaaaca gtgccaaacg gcagcgcatc ctccgctgtt acttttttgc tgaaaatatc 2678641 ccaagcgtca ccgtcatatt tgacgccagc tgcgattgcc tttgtacagt caatcacact 2678701 gcctccgccg acagcaagca gaaaatcaat gtcatgctct ctgcaaagtc ctatgccttt 2678761 ttccactgtc gcaagacgcg ggtttggctc tacacctgac agctcatgaa caacagcgcc 2678821 ctcttctttt aaaatgcctg tgacttgatc ataaaggccg ttgcgtttaa tgctgccgcc 2678881 cccgtaaaca agcagtacat tcttgccgta tcgtttgaat tcttttctta attgttcaag 2678941 ctgacctttt ccaaaaatca gctttgtcgg attataataa gtgaaatttt ccatagtaaa 2679001 acctccaaat gatgctggta aaaaacagat tttccattgt aacataagtt gacaaaaaag 2679061 aaaaagggaa gcagccaaac ggctatttcc ccttttttta tagtgatgct ttcaaaattg 2679121 acagcacatc ttctttgttg agtgatttaa attggccgaa tgtaccgtta gccattgcct 2679181 tgtcagcgat tgtgtcaagc tgctcatcat taatatcata atcagcaaga cggttcggag 2679241 cgccaagact tgtccagaat gcggacagct tatcgatacc ttcaagggca atttcttcat 2679301 ccgttttacc tgcttcttca acatcaaaca cgcgaactgc aagctgtttc atgcgggcag 2679361 ggttttcaga caatgtgtgt ctcatccaat tcgggaacag aatcgccagt ccgccggcat 2679421 gcggaatatc ataaacggct gatactgcat gttcaatatt atgagtagcc caatcccctc 2679481 ttgcccccat agaaagcatg ccgtttaatg cgattgttcc tgtgtacagg atcgtctcac 2679541 gcaattcgta attttcgaga tcattgatca gcttaggcgc tgtttcaatg actgtacgca 2679601 aaagtgattc acacatgcgg tcctgatacg gcgtgtttga tacatgatgg aagtattgtt 2679661 cgaatacgtg gctcatcatg tcaaccatcc cgtagatcgt gtggttttta ggtacggtga 2679721 atgtattcac cggatcaaga atcgagaatt tagggaatac gagcgggctg ccccagccgt 2679781 atttttcttt tgtttcccag tttgtaataa cagatcctga gttcatttct gaaccagttg 2679841 cagcgagagt caataccgtt ccgaatggca aagcatcttt tggctgatgc tttttcgtaa 2679901 cgatatccca cgcatcacca tcatacttcg ctcctgcggc aatcgctttt gtacagtcga 2679961 ttacgcttcc gcctccgaca gccagcaaga aatcaatgtt ttgttcttta cagatggcaa 2680021 cacctttatt aacagtcgac acacgaggat tcggttccac acctgctaat tcatgcacgg 2680081 tcgctccggc tttattcagc tgttcaatca cttgatcata caggccgctg cgtttaatgc 2680141 tgccgcctcc gtacacaagc aatacgtttt ttccgtaagg tttgagttcc tccggaagtc 2680201 tttccacttc gccgcgcccg aaaattaatt tggtcggatt ccagtatgta aagttttgca 2680261 tgacatctcc tccttagatt ttttattatg cagaatgtcc tcaccacatg taaagcaatc 2680321 agctctcacc gatcagcata ccagatggtt ttattttgca aggtgctggg aaagaagctg 2680381 atataagcga gggcaggcca gcttccctca tatggagaat gcatgtatag attctccaat 2680441 atgtcacaat ctataactgt tttaataatt catggaggag gttgcaaaac atgagtacca 2680501 ttcaaagaat ttgtcttgta ttaaccatca ttggcgccat taactgggga ctgatcggat 2680561 ttttccaatt tgacttagta gcggctatct tcggcggcca agggtcagct ctttcccgaa 2680621 tcatttacgg acttgtcgga atcgccggct taatcaacct cggtctgcta tttaagccaa 2680681 acgaggaaag atcacgtgaa gaagcagcaa atcctgaaat gcgataggat atcaatcacg 2680741 ctgaaatagg attttgcatg aaatcaaaag caccgaacat tcctgtccgg tgcttttttc 2680801 atgcttattt tttgataagg tctttgcggt tggacatttc gatccactct tcaagcttat 2680861 cttttaatgt gttgaaacct tgtggtgtag aagcttcttc gcttacttga gcagctttag 2680921 gttttcttgg tttgctttct tttttctcag gcgcagcttg tgtcgcacga attgaaaggc 2680981 tgattttgcc tttttcttca tcaacagcaa gtacttttac ttgtacttcg tcgccaactg 2681041 aaaggtgctc gttgatatct tttacgaaac cgtgagtcac ttcagaaatg tgtactaaac 2681101 cttgagtttc ttcatctaat gcaacaaacg caccatacgc ttgtaatcct gtaactttac 2681161 cagtgtaaac actgcccact tcaaattttg ctgccattca taacaactcc taagttaaat 2681221 taaatatctg tttatacgca atttaaaatt atatcacaca tgtcttattt ccgcaaagaa 2681281 aactttttta taaaaaatca ggtttatgca cagcaaaaag ggggtaaact gaaaatacca 2681341 aaggctttct agtattcccc ccttttattg gatgcgaaca aaaggttcgt atcttttttt 2681401 atgttgtttt gtgcaggaag cgtttcattc tgactaacgc ttcttgaagc tgttcaatcg 2681461 aggttgcgta tgaacaacgg atatatccct caccgctcgg accaaacaca cttccaggaa 2681521 caactgccac tttttcctgc gtcagtagct cctcggcaaa ctgttctgaa ctcattccca 2681581 tgcttttgat agatggaaaa gcatagaaag cgccgcccgg atgatgacag ctgagaccga 2681641 tttcattgag cgattctaca aacagattcc gtcttcttcg atagcttttt ttcatttttt 2681701 ctacgtcttc catgccgttc ttcaggcctt caagggcggc aaactgcgcc attgcgggcg 2681761 cgcacatcat cgcatactga tgaattttaa gcatggcatc ccgaagcaag gatggtgccg 2681821 cggcaaaacc gagcctccag cccgtcattg caaatgcttt tgaaaagcct gagatgacta 2681881 ccgtccgttc cttcattccc ggtaatgccg ctatacttgt aaattcctca tcatatgtca 2681941 gctccgcgta gatctcgtcg gctaagacga tgacatcatg ttttttggca aactcagcaa 2682001 tctcattcag ctcttccttc gaataaaccg aacctgtcgg attcgatggt gagcagatga 2682061 gaatggcctt tgttttttca gtgactgccg cttcaaaatc agcagccgtt gctttaaatc 2682121 ctttgtctgc cgttgtatga acgtgaaccg ggataccgcc tgccaaagaa acaagcgcat 2682181 cgtacgcaac aaaacacggc tcaggaatga tgacttcctc acctggattc acaatggcgc 2682241 ggatcgcaat atccaaagcc tgacttgccc ccactgtcac aatcagctca ttatctggcg 2682301 agtagctaag gtcaaacctg ttgctcaaat aacggctgat ttcctcccgc aatgagtata 2682361 aacccgcatt ggccgtgtat gacgtatatc cttgttcaag agagagaatg cttgcttcgc 2682421 ggacattcca tgcggtaaca aaatcaggct cgccgacgcc taaagaaatg acgccttcca 2682481 tcgttgccgc caaatcaaag aatttgcgga tgccggatgg ttttatttgt tgtacatagt 2682541 ctgataaata cgaagtcatt tacggtgaca ccacgattct tttgtcgtcg tctcctgttt 2682601 caaacacttt gccgtcatgc ttgtattttt tcaggataaa atgggttgtc gtagatacaa 2682661 ctgaatcaag cgttgagagt ttatccgaaa caaaacgcgc tacgtcagac atcgaattgc 2682721 cgcgaatcac gacagacaaa tcgtatacgc ctgacatcag gtaaactgat tcaacctctt 2682781 ggaatcggta aatccgttcc gccacttcat caaaaccgac gccccgcttc ggcgttactt 2682841 tgacgtcaat catggccgta acgccctcat gtccgtcgac ttttcgccag tcaatcatag 2682901 cggaataatc gataataacc ttttctttct ccagtttgtc aataattgtt ttcacttcat 2682961 ttacagggat gcccgccatc tttgcgattg tttctaaatc ggcgcggctg ttttcgtcta 2683021 aaatttctaa tatttctgtt tctttttctg tcaatttcat ttgattcaca cctttgcaat 2683081 gtcaagaaat ctcatgacat tatatcacgt tttttgacga atgctaagaa aaaacgagga 2683141 gaaacttccg ctagaattga caatttcagg gcataataca accatcaaaa aaagggagtg 2683201 acacagaatg gaggcggttt caccaataag gcggtttacg gtcgatggag tcaatgtata 2683261 ctacgaacat tatcaaaatc ccggcaggca aacgctggtc tgcgtacacg gttttttatc 2683321 atctgcattc agcttcagaa aagtaattcc tctccttcgg gacaagtacg acatcatcgc 2683381 gcttgatttg cctcctttcg gccaatctga aaaatcaaga acgtttatct atacctatca 2683441 aaaccttgct aagcttgtca ttgggatttt ggagcacttg caagtgaaac aggctgtgct 2683501 tgtcgggcat tctatgggcg ggcagatatc gctgtctgct gctctccaaa aacctgagct 2683561 tttttcaaag gttgtgctgc tttgcagttc agggtattta aaacgttcac acccgacgat 2683621 tattttcggg acccatatcc cgtattttca tctttacatc aaacgctggc tctcgaaaga 2683681 aggcgtgatg aaaaatttat taaatgtggt gcatgacaaa tcgctgattg atgaggagat 2683741 gattgacggc tatggcagac cgtttcagga cgagcagatt ttcaaagcca tgacaaggtt 2683801 tatccgccac agagaaggag atttagaacc cgagcaattg aagaaaatga acaagcctgc 2683861 tctattgatt tggggcgagg aggatcgaat tgtcccaatg gagatcggta aacggctgca 2683921 cgcagatttg cctaattccg tgctgtactc acttggccag accggacatc tggtgcctga 2683981 agaacggcct gaacttattt ctgaacacat tgctgatttt atcaaataac aaaaaaaccg 2684041 gtgctgaacc ggttttttta aggcgtgcag gagctgctgt ttttaatgaa taaaagctgg 2684101 ccagccactt cccggcagct ggcgatcggc agcgtttgtt caaaagaagt ttcaaatatt 2684161 tgctgaatgc ttttcgccag caagtcggga tcgttttcat catagactgc ctgcacgaca 2684221 tcaacagcct ccgtttcgta aaactcttct ccatatttaa acgggtccca tttggcaatg 2684281 atcttaatca tttccctgac cgcatgactt tcttccatat tcatcaccgc ttataataaa 2684341 atttgcagtt ctatcttatc atagtgaagc ttagaagaat aaacatacat gagggggtaa 2684401 cagaatgaac tttgataaac gagaagaacg ccttggcacc caatcggtca aatgggataa 2684461 aacaggcgaa ttatttggcg tgacagacgc cctcccgatg tgggtggcag atatggattt 2684521 tcgcgccccg gaagcgataa ctgaagcgtt aaaagagcgt cttgaccacg gtatttttgg 2684581 ttatacaact ccagatcaaa aaacgaagga tgctgtgtgc ggatggatgc aaaacaggca 2684641 cggctggaag gtaaatccgg aaagcatcac attcagcccc ggcgttgtaa cagctttgag 2684701 catggcggta caagctttta cggagccggg cgatcaagta gttgttcagc ctccagttta 2684761 tacgcctttt taccatatgg tggagaaaaa cggccggcac attttacata atccgctgct 2684821 agaaaaagac ggcgcatatg caatcgattt tgaagatttg gagacaaagc ttagtgaccc 2684881 aagcgttaca ttgtttattt tatgcaatcc tcataaccct tctgggcgtt catggagccg 2684941 ggaagattta ctgaagctag gcgaattgtg ccttgagcat ggcgtcacag ttgtatcgga 2685001 tgaaatccat tccgatttaa tgctgtacgg acataaacac acgccgttcg cttcgctctc 2685061 tgacgatttc gctgatattt ccgtgacatg tgctgctcca agcaaaacat ttaatatcgc 2685121 cggattgcag gcttcagcga tcattattcc ggatcgcctg aagcgcgcca agttttccgc 2685181 aagccttcag cgaaatggtt taggcggact gaacgcgttt gccgtcactg caatcgaagc 2685241 cgcgtattca aaaggcggac cgtggcttga tgaattgatc acttacattg agaaaaacat 2685301 gaacgaagcg gaagcctttt tgagcaccga gctgccaaag gtcaaaatga tgaagccgga 2685361 tgcatcatac ttgatttggc tcgacttcag cgcttacggc ttgtccgatg cagagcttca 2685421 gcaaagaatg ctaaaaaaag gaaaagttat tttagagccc gggacgaaat acgggcctgg 2685481 cggagaagga tttatgcgcc tgaacgccgg atgctctctt gcaaccctgc aggacggcct 2685541 gcgccgcatc aaagccgcat tatcgtaaat atagctgtaa acgcctttac gtcttcattt 2685601 gtaaaggcgt tcttaataaa ggaattttat attttacttc taatatttag tgttataata 2685661 gattcatatt ttatacgaaa ggatttcaca cgaatggaaa ttctaaaaga ctatcttctg 2685721 cacatctgct ttattttgtt tcctattctt ctttaccaag tgttttggct tggaaaacct 2685781 gcgattcttg tgccaaaaat aaacagcggt ttggtcacgc tcttcgcctg cggcgcctcc 2685841 gttttatgca ttattttccc gattcatgaa atggactaca tacaatacgg ccttcagatg 2685901 attcccgtta tcatttgttt attttacatt agtaccgctt ccggacttac agtcgccgca 2685961 tctgtcctat gttttgaact gcttttttac gaaccttccg caatgtttgt tttcactttg 2686021 ctgccttttc ttatcattat cccaatctta tttcagaaaa aatggccatt catgtccaaa 2686081 gcgaaaaaac tgctgctgtc tttattgatc agctgcgtgg agattttcct atttttcgcc 2686141 tcaagctgga ttctttccgc cttgaatatt ttaaattttc aaaaatcagg aattttcgtt 2686201 tacgaggcgg cagtctcagg gcttttccgc tccagtgttc ttctattaag catctatatt 2686261 atcgaaagca tcgccgaaaa tatcgccctg cgttcacagc ttatccattc tgaaaaaatg 2686321 acgattgtga gtgaactggc agcgagcgtc gcccatgagg tcaggaatcc gctgacagtt 2686381 gtccgcgggt ttgtccagct gctttttaat gacgaaaccc tacaaaacaa gtcgagtgcg 2686441 gattacaaaa agcttgtact gtcagagctt gaccgggcgc aaggcattat cacaaactat 2686501 ctcgatatgg ccaaacagca attatacgaa aaagaggttt ttgacctatc tgcccttatc 2686561 aaagagacaa gctcccttat ggtgtcgtac gccaattaca agtcagtaac cgtcgaggct 2686621 gaaacagaac cggacctttt gatatacgga gacgcaacaa agctgaagca ggctgtcatc 2686681 aacctgatga aaaacagtat tgaagcggtt cctcacggga aggggatgat ccacatatca 2686741 gccaaaagaa acggccatac gatcatgatt aacatcacag acaatggggt cgggatgaca 2686801 gaccatcaaa tgcaaaaact cggcgaacct tattattcct taaaaacgaa cggaacggga 2686861 ctcggcctca ccgtaacctt ttccattatt gaacatcatc acgggaccat ttcatttaac 2686921 agcagcttcc aaaaaggcac tacggtgacc attaagcttc ccgctgatct tcctcactag 2686981 caaatcgatt ggaactttaa tagaataaat gcgaggtgat gacagatgag cacgtttgag 2687041 acaggctcta tcgttaaagg attttacaaa acaggtgtat acataggaga aatcacggct 2687101 tgcaggccgc agcattattt agtgaaagtg aaagcggttc ttacccatcc cgctcaggga 2687161 gaccttcatc atccaaaaca ggcggatgtg ccattttttc atgagagaaa agcgctcgca 2687221 tatggtgaac agaccaatat cccccaccat atggtgaagc cttatgacgg tgaagtgccg 2687281 gattataccg aatctctgcg ggaggcgaca gcacagatga gagccaaatt gaatgaggat 2687341 ggttcggagt gggcaaagcg ctcccttcat aatctggaca ttttagaaaa agaatatttt 2687401 aaccggccat aacccagtct gacaaaagat tgggtttttt acgtcgcgcg cttcaacagt 2687461 tcggttaaat cgattctctc gccgattgtg ggcggttttg gcttttcgag atactgctta 2687521 tcctgctcaa caagcttaaa aagtttatat gctgtgagag catcatcaag cgctttatga 2687581 tgggtgccgg ttccggaatc tccatactct tcggcagctt tccataaacc cgtcaatgtc 2687641 cggtctccaa aaaagttttt gtattcaagc gataaatctc tcatttctcc cttaaacggg 2687701 aaagggatat ggttaaacat acagttttgc ttcagcactt tcatatccat gtttccccac 2687761 gtaataattg tgctgttttt ctcaggatcc agctcgttta gtttacggat gaaatcctcg 2687821 aatctcattc cttcgtctac ctgtttttgg gttattttta aaaatgattt gcagcgtttc 2687881 gtaagcttcg ggaacttttt cggtctaaca tagctagaaa acgtctcaac cacttcatca 2687941 tcaatcgact ttacaattcc ggcttcaatg atttccggga agaagttttg aggactgtac 2688001 tttccatcag gcattgtaaa ttcgaaatca ataatgagta agctgtttgt cgtcaccttt 2688061 tacacctgcc tttcctccga tcagaaaatg ctatctttat agtatatcaa ttccccttct 2688121 cgacatttct tcattttcta aaaataatga attttcccag ccgcttcgtt tcttttaaat 2688181 tgtgaatcgt ttctttataa ttagtaagga acccgaaata ataagaaggt gatgttattt 2688241 ctatccgtaa gaaaaacttt gtcattgtgt ggctggcgaa cttttttgtc tccgctagca 2688301 caacgatgat cgttcctttt ctctccttat acattgagac gctcagctct ttttcaaacg 2688361 gctttgtgca aaggtggagc ggctatgtgt tcggcattac atttctcatg gcgtttttgg 2688421 tatccccgtt ttggggacgg ttcggagaca aacgcggata caagaaaatc cttatggcaa 2688481 ccggaacagg cattgccctc agcattttct tcatgggctt tgttacatcg gtgtaccaat 2688541 tgttttttct gcgtatggca atgggtcttg taaccggatt catcccgaca tctcttgcga 2688601 tgatttcggc acagactccg aagagctcag ctggcaaaac actcggcacg ctgcaaatgg 2688661 ggcaagtgtc cggaagcttg ttcggcccgc ttttgggagg catgcttgct gatcgtttcg 2688721 gctttacgta tacctttttt atcacatcct ttgtgatttt ctcgtctgtt cttctcgtgt 2688781 tatttggtgt caaagaaaag catcttgcag agaaaacagc caaacgtacg tcttactcga 2688841 gaaaagaagt gctctcctat atttttcacc atccggcgct gtgggtcatg atgctgttaa 2688901 ccatgctgat tcaaacaggc aatttcagta tccagcccct gctcgcttta tatgtaaatg 2688961 agctgcacgg acctgtcaat cttgcctttt tctccggcat ggcattttca gcaacggggc 2689021 tcggaagttt gctgctggct agaaaatggg gtgatctggg cgaccgctac ggccaccgcc 2689081 gcattttaat cggacttttg ctcgccgcct ctttcttttt tattccgcag gcgctcgcgt 2689141 cctcactcag cgtgctcctt gttttcagat ttttattcgg aatggcgatg ggcggtttgc 2689201 tgccatgcat tacggcagcg atccgcgttc aggctcccgg cagcattcaa ggtgaagttc 2689261 tcggctacaa tgtcagcttt cgctttttag gaaacgtgct cgggcctctg ctcggcggaa 2689321 tcatatcgag ccattttacc atttcggcca ccttttacgt cacggcgttt ctctttttcg 2689381 ccggcgcctg catgctttgg atcatgcaga aacttcggaa agattcttat gccaaagcaa 2689441 gctgattccg agaaaaaact aaggaatctt ctaaatttaa ccttctcgta atctcaaaag 2689501 aatggtacga tatggctaga atttaggaga aaagagagtg accatgttac gaaaaataat 2689561 cggatggatt ttgctccttt gcataatccc attgtttgca tttacagtta tcgcttccgg 2689621 aaaagaagta aaacaaatga agtccctgga tcaggtgctt gataaaaata ttgatctgaa 2689681 agatatcagc cttgttcaga acagctacat gtatgacagg gacggctccc ttgtctcgga 2689741 aatcgtcagc gaccacgaaa accgtgtgct cgttccattt aacaagattc ccgaggaagt 2689801 caaacagatt ttcttaacat ctgaggaccg ccatttttac gagcataaag gctttgactt 2689861 tatgggaatg gtgcgggcta ctgcttctaa cgtaaaagac aagaaaattg accagggtgc 2689921 cagcaccatc acacagcagc tttcaagaaa cttgtatttg agccacgaac gctccttcag 2689981 ccgcaagctg acagagctcg cgtattccta tcagctggag aaaaaatata cgaaaaatga 2690041 aattcttgaa gcttacttaa ataccattta tttcaacaac ggtgtttacg gcgtcggttc 2690101 agcagctcaa ttctatttca gcaaaccgct gaaatctctc acagtgggag aaatggcttt 2690161 tatctgtgct atacctaata accctacatt atatgatcct ctcaagcatt ttgactacac 2690221 gaaaagccgt caagaacgtt tacttaaagg gctaaaagat gccggggtca ttacggacaa 2690281 agagctgaaa aaagccgtaa aacaaaaaat caaactggat gttgaaaaaa gagaagacaa 2690341 atatcctgac tacgtttcct acgtcaatga tgaattcact cagctggtgt ctgaatcaga 2690401 aggctttgat aaacgccttc aaaaagcatc aggaaaacaa aaagaaaaga tcgagaacga 2690461 gctgtccgca agagtcagca cgctgatgaa agacggagtg aaaatttata ctgcacttga 2690521 tccgtacatg caaaatcaag ttgtggcaca aatgaattcc aagctcccgt atgcggacgt 2690581 acagggcgga gcggctgtga ttaatcacca gacgcatcaa atcattgctc tatccggcgg 2690641 gaaaaactat caaaaatatg actttaaccg cgcctaccag gcgtacaggc agccgggttc 2690701 atccattaag ccgcttcttg attacggccc ttatattgaa cagaccggcg cgacaacaag 2690761 cagcaccatt gatgccagca agttttgcag caaagactac tgtccgcaaa actacaataa 2690821 ccgcacttac ggcacagtga cgcttgatac ggcgtttaaa aattcatata ataccccggc 2690881 tattagaatg ctcgaccgcg tcggcatcca aaaggcattc agttatattg agccgtatca 2690941 ttttgccaaa cttgtcgaca gtgactatct tcttccggcg gcgcttggcg gatttacaaa 2691001 cggcatgacg cctcttgaga tgacaaaggc ttatacgaca ttcggaaaca gcggaagcta 2691061 tacgccgagc catgcgatta caaaggtgac agaccttaaa ggaaaaacac tttataaatg 2691121 gaatgataaa gcgactcaaa tattcagcgt ccgcacgaac atgcagctga aaaaactgat 2691181 gtcttccgtt gtgaaaagcg gaacagggaa aaaagcatat ttcaatgcgc cttacatcgg 2691241 cggtaaaacc ggaacatcaa atgattatca cgatatgtgg tttgtcggcc tgactgatac 2691301 gtatacaatg ggtgtctggg tcggaaagga tacaccgacc agcgttgaat atcttcacag 2691361 catcagccct cagctttcca tctggaaagg aacgctgcaa gcggcttatt aaaggatcgg 2691421 aggggatatg gagtgacttc agaacaaatt ccaaatcgcg ttttgctgtt tgacggtgtc 2691481 tgcaatttat gcaatggcgc cgtgcagttt atcattaaac gtgatccgga cggattgatt 2691541 tctttcacat cgctgcagtc ggaaacagga cagagcctgc tgaaaaaaag cgggcttccg 2691601 actgatcggt ttgacagctt tgtctttatt gaagacggcc aagtgtacac aaagtcaact 2691661 gcagccatta aggttttcag gcatctgcga ggcccatggc ggctcttcgt cctttttttc 2691721 gcagtgccga agcctgtcag agatatggtc tattctttca ttgccaaaaa ccgctataag 2691781 tggtttggca aaaaaaatga atgtatgctc ccctcccctt ccattaaaaa aagattttta 2691841 ccgtaaataa aaaatggcta ggaagctagc catcacagat tgttgacaaa atcctaaaac 2691901 ggcttcgttt taggattttg tcatctattc agcgtgattg aaaacttttg aagttgtgaa 2691961 acggcggaaa cctgagaatc tagccgccgt ttcattgcgt acagagcacg aagcgcaaat 2692021 ctgaccacca aacgctgaaa tggctagctt acacaggtaa gctagccatt atgctattat 2692081 aaagcttgat aaatatgaac agaataccga taacaaaggt aaaccaaaac agcagttcca 2692141 atagaatgaa tccaactaat gacatgagag aaagcgtcga ataaatccgg tatacggtaa 2692201 acacaaagta agcgagcgtg acgaccgcaa accagatcac aatccaaatg acattttgca 2692261 agagcacaaa ggataaaatc ccgccgccca aataaatcat ggaacccatt ctgagttttt 2692321 tcaggttgtt cccttccgga tcattagcaa aaaacagcaa tgacagctcg gtcacggtat 2692381 ttgcaattaa tttcagagcg gacagaacca taaaatataa aagtgcaaag gcagcaaata 2692441 acgcaagcct gattcctttc tctgaaaaat aatcgagcat tccatcatac attccaaatg 2692501 aagacagcat cttcaacgca taaagtgaag ttgagatgga taaggacgaa ctaaaaagca 2692561 ggatcgcaat cagcggaaaa tatcctgtca aataagtatt tttcatataa aaaagtccct 2692621 ttctataatc tacctcattt attatggagg acttaaaaca cattgacaag ataaattatt 2692681 ccattttttc tcctttttac gaattacggg cccaaatctt cacaaagcag cattttgaga 2692741 gtaaagtagt acgcaggaat cataaaacgt aaggaagttt tatatgaaaa aaacattaaa 2692801 actgcaaacc agactcacca tatttgtttg tatcgttgta ttaatcgcat tgctcattac 2692861 gttttttaca gtcggtgccc aaaccaccaa acgaattaga gatcaggaaa aggccactgc 2692921 gctgcagact gctgaaatgg tagctgaagc gccgatgaca gccgctgctt tagaaagcgg 2692981 aaaaaaacaa aaggaactgc agagctacac aaagcgggtt cagaaaatta ccggcacgga 2693041 atttgttgtc gtcatggata tgaacggtat ccgcaaaact catcctgacc cgagcaaaat 2693101 cggaaaaaaa ttcagaggcg gtgatgagtc cgaggtatta aaagggcatg tccatatcag 2693161 cacagcctct ggcacgctcg ggaaatcgca gagagcgttc gtccctgtct acgcggagaa 2693221 tggaaaacag gtcggtgcag tcgcggtcgg catcaccgta aatgaaattg atgaagtgat 2693281 cagccatagc ttacggccgc tttactttat tatttgcgtc agcatcttcg tcggtgtgat 2693341 cggagccgtt atcgtcgccc gtacagtgaa aaatatcatg tacggacttg aaccttatga 2693401 aattgcgact ctgcttgaag aacggagcgc gatgctggaa tcgacgaagg aaggaatact 2693461 cgctgtcgat gaacatggca aaattaaact tgccaacgcg gaagcaaaac gcctattcgt 2693521 caaaatgggc atcaacacaa atcccattga tcaggatgta gatgacatct tgccgaaaag 2693581 ccgcttgaaa aaggtcattg agacaaaaaa acctcttcaa gacagagacg tccgcattaa 2693641 cgggctggag cttgtgttta atgaagttcc tatccagctg aaaggacaaa ctgtcggagc 2693701 gattgcaaca ttccgcgaca agaccgaggt aaaacattta gctgaacagc tttccggtgt 2693761 taaaatgtat gcaaacgcac tgagagcgca gtctcatgaa tttatgaaca aactgcatgt 2693821 gatattaggt ctcgtccagc tgaaagagta tgatgatctt ggagattata ttaaagatat 2693881 agccatacag caaaaatcag aaacaagtga aattataaat gatgtcaaaa gctccgtact 2693941 ggccggtttt ctgcttggaa agcaaagctt tatacgtgag cagggcgcaa atcttgatat 2694001 tgaatgcaac ggtgtcatcc cgaacgcggc agacccttct gtcatccatg aacttattac 2694061 aatcatcgga aatctcatca acaatggctt agatgccgtt gccgatatgc cgaaaaaaca 2694121 aatcaccatg tccatgcgct tccataacag catacttgat attgaaatta ccgatactgg 2694181 agcaggcatg tctgaagaag accaagccaa agtatttgaa caaggctatt caacaaaggg 2694241 caaaaaccgg ggattcggcc tttatttcac acagcaaagc atcgaaaatt taaaaggcca 2694301 aatgatcctc acaagcgaaa agaatgaagg aacgacattc agtattcgca tcccgtacga 2694361 accgaaggag gaaaatcatg attaatgtac taatagttga agatgacccc atggtgggtg 2694421 aattaaataa acgatactta agccaaatag atggctttca gctgaaaggc atcgcttctt 2694481 cctttcaaag cgctctgcat attttagggg agcaccatat tgacctcatt ttgcttgata 2694541 tttatatgcc gggaaaaaac gggctggaac tgctgacgga attgagagcc caaaatgaag 2694601 cggttgacgt gattgtcatc tcagcggcca gcgagcttga cgtgatcaag aaaacacttc 2694661 ggtacggagc tgttgattat ttaatcaaac cgtttgaatt tgaacgattc caaacggctc 2694721 tgtctgatta cagacgaaaa caaaaggtgt attcaaccca tcgcaacatg agccaaaaag 2694781 aactggacgc cgagcttttt caaaagaaag aagcaacaga aaaagtgcag cttcctaaag 2694841 gcctgacaaa aagcacgctg aagctgatct ggtccagtat ccagtcattt gaaaatgaat 2694901 cttttacgac agaagacttg gcaaagcaca cagaaatctc tcaagtatcc atacgaaaat 2694961 acttaaagtt tcttgaagat atacaggttc tgaatgtaga aatggcgtac ggaacgatcg 2695021 gaagacctgt gtttcagtac aacgtcaaca acagtaacat taacggaata aagcaatatc 2695081 tataagaaaa cgcactgctt gctttgagca gtgcgttttt ctgtcatatc tcttgccaag 2695141 atgcttgatt ctattgttga taagttatac aagaataaca aagggctttc acatttttaa 2695201 gcaaataatt ctaaaaatag ataattttta aaaaattatg cgaaattcta tttatttctt 2695261 attagttaaa tgataaatta tgattggtta gttgatcccg aaaaactaag tcataagtct 2695321 tacttcagaa aacgatgtca cggttttccg cccggaacgc cttccgcatc cttctcttcc 2695381 ccgcctttcg aaggaaatac tcacaccacg cttattcagg gaagaataga actgtctcag 2695441 cgcattccat ttgttattat cagaaaattt tatcgattct aagaaattgt tcaggacagc 2695501 ccatcacatg actggccgga tcagctttga accaaatttt tctggggggt tatatcttga 2695561 ataaacgaaa aatcggattg gcgatgtcac ttgtgatcgc agcaggcacc atattaggag 2695621 catgcggaaa cagcgaaaaa agcagcggct caggcgaagg caaaaacaaa ttcagtgtgg 2695681 cgatggttac tgacgtaggc ggagtggatg acaaatcctt caaccaatca gcctgggaag 2695741 gcatccaagc ctttgggaaa gagaatgggc tgaaaaaagg caaaaacggt tacgactatc 2695801 ttcaatccaa atctgatgca gactatacaa cgaacttaaa taaattggcg cgtgagaatt 2695861 ttgacttaat ttacggcgtc ggctacttaa tggaggattc aatcagcgaa attgctgacc 2695921 agcgtaaaaa tacaaacttt gcgattatag atgctgttgt cgataaagac aacgtcgcaa 2695981 gtattacgtt taaagagcag gaaggctcat ttctcgtcgg agtggccgca gccctatcaa 2696041 gcaaatcagg aaaaatcggc tttgtaggcg gcatggaatc agagttgatc aaaaaattcg 2696101 aggtcggctt ccgtgccggc gtgcaagcag ttaaccctaa agccgttgta gaagtgaaat 2696161 acgcaggggg tttcgataaa gccgatgtcg gtaaagcaac cgccgaaagc atgtataaat 2696221 caggcgtaga tgttatttat cactctgcgg gcgccactgg cacaggcgtc tttactgaag 2696281 cgaaaaacct gaaaaaagaa gatccaaaac gcgatgtctg ggtcatcggt gtcgataaag 2696341 accaatacgc agaaggccag gtagaaggaa cagatgataa cgtcaccctc acttccatgg 2696401 tgaaaaaagt agatacagtc gttgaagatg taacgaaaaa agcgagtgac ggaaagttcc 2696461 cgggcggcga aacacttacc tacgggcttg atcaagacgg agtcggcatt tctccatcta 2696521 aacaaaatct atcggatgat gtgatcaaag cggtcgataa atggaagaaa aaaatcatcg 2696581 acggattgga aatcccggca actgagaaag agctgaaaac cttcaaagct gaataagaat 2696641 cgcagggata aggaggtcga gcccttatcc cttgtttttc ttttattttg aaataaagga 2696701 gcggtcaatc aatggaatat gtcattgaaa tgctcaatat ccgcaaggcg tttccaggta 2696761 tcgtcgccaa tgacaatatc aatcttcaag tcaaaaaagg cgaaatacac gcgttgctcg 2696821 gtgaaaacgg agcggggaaa tcaacattga tgaatgtcct tttcgggctg tatcagccgg 2696881 agcggggtga aattcgggtg cgcggcgaga aggtgcacat caacagcccg aacaaagcga 2696941 atgaccttgg aattggaatg gtgcaccagc actttatgct tgttgacacc tttacagttg 2697001 ctgaaaatat tattctcggg aaggagccaa agaagtttgg cagaattgac cggaagcgtg 2697061 ctggccaaga ggtgcaggac atttccgatc gatacggcct gcagatccat cctgaagcaa 2697121 aagcagctga catatcagtc ggtatgcagc agcgcgcaga aatattaaaa accctctacc 2697181 gcggtgccga cattctgatt tttgatgaac cgacggctgt tttgacgcct catgaaatta 2697241 aggaactgat gcaaattatg aagaacctgg tcaaagaagg gaagtccatc atcttaatca 2697301 cccataagct gaaagagatt atggagattt gtgaccgcgt tacggttatc cgtaaaggaa 2697361 aaggcatcaa aacccttgat gtccgtgata caaaccaaga cgaactcgcc agtctaatgg 2697421 tcggccgtga ggtatcgttc aaaactgaaa agagagctgc tcagccggga gcggaagtgc 2697481 ttgcgattga cggcataact gtaaaggata cccgcggaat agagacagtc agagatttgt 2697541 ctctttctgt caaagcggga gaaatagtcg gcatagcagg cgtcgacgga aacgggcaat 2697601 ctgagctgat cgaagcggtg acaggactcc gcaaaacaga ttcaggaaca atcaccttaa 2697661 acggaaaaca gatccaaaac ctgacgccaa gaaaaatcac tgaatccggg atcgggcata 2697721 ttcctcagga tcgccataaa cacggtctcg tccttgattt tccaatcgga gagaatatcc 2697781 tgctgcaaag ctattacaaa aagccgtatt cagcattggg cgttttacat aaaggcgaaa 2697841 tgtacaaaaa agcacgcagc ctgatcactg agtacgatgt cagaacgccg gatgaatata 2697901 cacacgctcg ggcattgtca ggcggaaacc agcaaaaagc gattatcggg cgggaaatag 2697961 accgaaatcc tgatttatta attgccgccc agccgactcg cggccttgat gtcggagcga 2698021 ttgaatttgt ccataaaaag ctcattgagc agcgtgatgc cgggaaagcc gttcttctcc 2698081 tctcgtttga gcttgaagaa attatgaatc tcagtgacag aatcgccgtt atttttgaag 2698141 gacgcattat cgccagcgtt aatccgcagg aaaccactga acaggagctt ggtctcttga 2698201 tggcaggaag cacgcaaaag gaagcgggga aagcaaatgg ttaaacgact ctctcattta 2698261 ctcgtgccgc tcatcgcaat catacttggt cttgcggccg gcgcgttgat tatgcttgtg 2698321 agcggctaca gtgtggctag cggatattcg gctttgtgga atgggatatt cggagaaatc 2698381 tattatgtcg gagaaacaat ccggcaaatt acgccttata ttttatccgg attggctgtc 2698441 gcctttgcat tccgaaccgg actctttaat atcggcgtcg agggacagct gctcgtcggc 2698501 tggacagcag cggtttgggt cggtacggcg tttgacggac cggcatatat tcacttgccg 2698561 ctcgcattga ttacagcggc agctgcagga ggattatggg ggtttattcc cggcattttg 2698621 aaagcgcgat tttacgttca tgaagtcatt gtcaccatta tgatgaatta tatcgcgctg 2698681 cacatgacca attacatcat ttcaaacgtc ttgacagatc atcaggacaa gacggggaaa 2698741 attcacgaat ccgcctccct ccgctctcct tttcttgaac agatcaccga ttactcacgg 2698801 ctgcatttgg gaatcatcgt tgcccttctc gcagcagtta tcatgtggtt tatcatcaac 2698861 aaatctacaa aaggatttga gctccgggcg gtcgggttta accagcacgc ttcccagtat 2698921 gccggcatga gcgtgcggaa gaatatcatg acctccatgc ttatctccgg cgcttttgca 2698981 ggtcttgccg gagccatgga gggcctaggg acattcgaat acgcagcagt gaaaggcgca 2699041 tttaccggcg taggctttga cggtatcgct gtcgctcttc tcgggggaaa cacagccgta 2699101 ggcgttgtac tggcagcatg cctgcttggc gggctgaaaa tcggcgcatt aaatatgccg 2699161 attgaatcag gcgttccatc agaggtcgtt gatattgtga ttgccattat tattctattt 2699221 gtggcttcaa gctatgcgat tcgtttcgtc atgggcaaat tgaagaaaaa gggggcgaac 2699281 taagtggaca ttgtgcagat tttatctatc attgtccctg ccacactcgt ctatgcggcc 2699341 ccgcttattt taactgctct cggcggcgtg ttttccgaga gatcaggtgt ggtgaatatc 2699401 ggcctagaag gcctcatgat tatcggggcg ttcaccagcg tgttatttaa tttatttttt 2699461 ggtcaggaat taggtgccgc cgcaccttgg ctttcgctcc ttgccgccat ggcagcaggc 2699521 gccctgtttt cactgattca cgcggcagcg gcgatttcgt ttcgcgccga ccagacagtc 2699581 agcggtgtcg ccattaacat gctggcgctt ggggcaactt tatttatcgt caaactgatc 2699641 tacggcaaag cgcagacaga caaaattcca gagccttttt ataagacgaa aatccccggt 2699701 ttgggcgata ttcccgtctt gggaaagatc ttcttttcgg atgtctatta tacgtctatt 2699761 cttgcaatag cacttgcctt tatttcctgg tttatcttgt tcaaaacgcc gttcggcctt 2699821 cgtatccgtt ctgtcggcga gcatccgatg gcggccgata cgatgggaat caacgtatat 2699881 aaaatgcgct acatcggcgt gatgatcagc ggattgttcg gcggtctcgg cggcggcgta 2699941 tatgcctcca caattgcgct tgatttcacg cactctacca tctccgggca aggttttatc 2700001 gccctggcag cgcttgtatt cggaaaatgg catccgatcg gagcactggg ggccgccctg 2700061 tttttcggat tcgcccaaag cttaagcatc attggatcgc tgctccctct ttttaaagac 2700121 ataccaaatg tgtatatgct gatggctcct tatatcttaa cgattctcgc tttaaccggc 2700181 tttatcgggc gggcagatgc gccaaaagcc aatggcgtgc cttatattaa aggaaaaaga 2700241 taaacattct cccctgggaa gacgattctc agggattttt ttctaatcca aaagaccccc 2700301 ttaatttaat tgtttattag ttttttaact taaaaaaata tgaagtgtta acgctttctt 2700361 gtagactgta acaaacaata catgggggtg tatgacatgg gagcaattcc aaaaacgggg 2700421 acaatttcac ctgagcaaaa agactcacag gagaaaaacc tgtttcaaaa aatttggtct 2700481 tgggaaatcg gtgtgattcc tttgccatta tacacagtat tagctgttat tattattctt 2700541 gcagcatatt acaatgagct gccggcaaat atgcttggcg ggtttgccat cattatgatt 2700601 cttggtgtgt ttctcggaga cataggccaa cgcataccga tattgaagga tattggcggc 2700661 cctgctattt tatctttgtt tgttccttca tttttagtct tttacaatgt actgaattca 2700721 acatctttag acgctgtaac caacttgatg aaaacgtcta acttccttta tttctatatc 2700781 gcttgccttg ttgtgggaag tatcctcggt atgaacagaa ttgttttaat acaggggttt 2700841 atcagaatgt tcgttccact ggttgcagga acgatcgcgg ccgttgcagc cggcatcctt 2700901 gtcggattta tttttggcta tagtgcctat gattcctttt tctttgttgt tgtcccgatt 2700961 attgccgggg gaataggtga agggattttg ccgctttcaa tcgcctattc acaaatactg 2701021 ggctcatccg ccgatgtatt tgtgtctcag ctggtgccag ccgcaattat aggaaacgtt 2701081 tttgctatca tatgtgcagc cttaatgaaa aagcttggcg acaagcgtcc agatctaaat 2701141 gggaacggac gtctcgtaaa atctaaaaaa gcaaatgaga ttttcaatca aaaagaagcc 2701201 gaagcaaaaa ttgattttaa actaatggga gcaggagttc tgctcgcgtg tacattcttt 2701261 atttttggcg ggttattgga gaaattcatc ttcatcccgg gcgcgatctt aatgattatt 2701321 tcagctgcgg ctgtcaagta tgcaaatatt cttccgaaaa aaatggaaga aggcgcttac 2701381 cagctttata agtttatttc ttcaagcttt acatggccgc tgatggtcgg tctcggcatc 2701441 ctctttattc cgttggatga cgtagcgtct gtgatttcta taccgtttgt catcatctgt 2701501 atttcagttg ttatcgcgat gattggttct ggatatttcg taggcaagct gatgaacatg 2701561 tatccggttg aatccgcaat cgttacctgc tgccacagcg gtctcggcgg aacgggtgat 2701621 gttgccattt tatcggcatc aggaagaatg ggccttatgc cgtttgccca aatttcaacc 2701681 cgtctcggcg gtgcaggcac agttatttgc gcgacagtgc tgcttcgttt tttcacttca 2701741 taaacagaaa gagttccgtt ttatgcggaa ctcttttttt atttattcac aatccgaata 2701801 tactctcggg gaccaaacgg cagatccttt gattccgtct cactcattct ggctgacagg 2701861 tggtgctcca gtaaatacag ctcccactca tcacaagccg ccacaccgct gcgcccgtca 2701921 tattgattca acatgaatgc ccctgcaaat actgagcaga ataaacctga gcacatcacg 2701981 acttttgttt tcacatgacc agctcctttc cttcagcttg atcaggattg attttaaata 2702041 tacaaataac ctcttttttg ttagacttat tttgaggtca aaagaactca taaaaatcca 2702101 ttacagcagt tcgaagcgtg gcagcttgca gaaaagtgcg atataatttg gactaggtcg 2702161 tttgaccgta tattttatac atagcgcatt tttcaattga gaacgagaaa aggaggtctt 2702221 atctttgcag ctcttacatc ttgctatttt atcgcctttt ttatttgctt ttatcattcc 2702281 cttcttggca aaatacgcaa aaagagtgca tacgggctgg tttgtgttga tcctgcccgt 2702341 cttgctgttt atatactttc tcccaatgat caggatgacg caatctggag aaacacttcg 2702401 atcggtatta gagtggattc cgtcactcgg cattaacttt accgtttata tagacggcct 2702461 cgggttatta ttcgctttac tgatcacagg cattggctct ttggtcactc tttacagcat 2702521 tttttattta tcgaaagaaa aagaacagct tgggcccttt tatgtctact tattgatgtt 2702581 catgggcgcc atgctcggcg tcgttctagt agacaatgtc atggttctct acatgttctg 2702641 ggagcttaca agcctttcat cctttttgct gatcggctat tggtataagc gggaaaagtc 2702701 gcgctatggc gcagccaaat cacttttgat tacggtcagc ggcgggctgt gcatgctcgg 2702761 cggatttatt ctcctttatt tgataacgga ttccttcagt attcgagaga tggttcacca 2702821 ggttcaatta attgccggcc acgaattgtt tatcccggct atgattctca ttttattagg 2702881 ggcttttacg aaatcggcgc aatttccttt ttacatctgg ctccctgacg cgatggaagc 2702941 tccgacgcct gtcagcgctt atctccattc agctactatg gtaaaagccg gcatttatgt 2703001 gattgcgaga ttcagtccta ttttcgcctt ttcagctcag tggttttgga tcgtgtccct 2703061 cgtcggcctc tttacgatgg tttggggttc attccatgcc gtgaaacaaa ctgatttaaa 2703121 atcgattttg gcgttttcaa ccgtcagcca gctcggcatg atcatctcca tgctcggagt 2703181 cagtgctgcg gcccttcatt acggacatac agaatattat acagttgccg ctatggctgc 2703241 cattttccat ttgatcaacc acgcaacctt taaaggaagc ttgtttatgg cagtcgggat 2703301 tatcgatcac gaaacaggca cacgggatat ccggaagcta ggcggcctga tggcgattat 2703361 gccgattact tttaccattt ccttaatcgg gacattttca atggccggcc taccgccgtt 2703421 taacggattt ttgagtaaag aaatgttttt cacaagcatg cttcgcgtga cacattttga 2703481 cctgttcaac gtgcagacat ggggcgttct gttccctctt ttcgcctgga tcggaagtgt 2703541 atttacgttt atctacagca tgaaattgct gtttaaaaca ttcagaggaa attaccagcc 2703601 tgaacagctt gaaaaacagg ctcacgaagc gcctgtcggt atgctcgttc caccggtcat 2703661 tcttgtcgct ttggctgtca gtctcttctt tttcccgaat atattgtcgt acagcctgat 2703721 agagcctgcg atgaactcaa tctatccgac actgcttgac ggccatgaga aattccacgt 2703781 tcacatttca cagtggcatg gggttacaac ggaattgctc atgactgcgg gtattgttgt 2703841 gatcggaaca attggttatt tgtcgctgaa taagtggaaa ggaatctata aactgtttcc 2703901 ttcgaaactc acactcaacc ggttatacga taagcttttg actatgatgg agaaaggctc 2703961 ttaccgggtc acaaaacaat atatgaccgg gtttttaaga gattatttgc tgtatatctt 2704021 cgctggtttc atcattctga taggcggagc ttttgccatt aaaggcggat tttcatttaa 2704081 aacggaaggc atggctaaaa tcggtgtata cgaaatcatt ttgacgcttg tcatgatcag 2704141 cgccacagtg gcgactgttt ttgctaggtc aagactgacg gcgatcattg cactcggtgt 2704201 tgtcggttat acgcttgcat tgttttttgt cattttcaga gcgccggact tggcattgac 2704261 tcagctcgtc attgaaacga tttctgtggc actgtttctg ctttgcttct accatttgcc 2704321 gaaactgagg ctgaaaacaa aaacgagaac gttccggatg acgaatttta tcatttcttt 2704381 aggcgtcggt gttatcgtta cactgctcgg catcgcatcc tcaagccagc ggacaaaaga 2704441 cagcattgcg tccttctttg tcaaacacag ccacgatctc ggcggagggg ataatgtcgt 2704501 caatgtcatt ctcgttgatt tcaggggatt tgatacaatg tttgaaatta cggtattaac 2704561 gatagccgct ctcggcattt acagcatgat taaaacaaaa gtaaaagagg aggggaaaag 2704621 cggtgaatga acaaaaaaca aatgacttga ttcttcaaac cgcgacaaag cttgtatcct 2704681 ttatcatttt gcttttctct ttctatttat ttttatcagg gcataacgcg cccggaggag 2704741 gctttgtcgg cggactgatc acgtcctctt ccatcgttct cttgctcttg gcatatgatt 2704801 taaaaaccgt gcgttccctt ttgcctgtca atttcattta tgtcgcggga gccggccttc 2704861 tgctcgctgt attaacaggc gttggctcct ttgtcttcgg ggctcctttt ttaacccaca 2704921 cattcggata ctttcagctg ccgatccttg ggaaaacgga gctcgccaca gcgacgatat 2704981 ttgatttagg cgtttatctt gttgtcgtag gcataacgat gaccattatt caaacgattg 2705041 gagaggaaga ataatggaaa tcttaatggc tgtattagcc ggtattattt ttatggctgc 2705101 tacgtatttg ctgctgtcta aaagcctgct tcgcgtcatt atcggaacag cactgttaag 2705161 ccatggcgtt catttaatgc ttttgactat gggaggatta aagaaaggcg ccgctccgat 2705221 tttgagcgag catgccaaat catttgtcga tccgcttccg caagccctga ttttgaccgc 2705281 aattgtcatt tcttttggcg ttacgtcatt catcctcgtc atggcctttc gcgcttatca 2705341 ggaattgaaa tcggacgata tggatcaaat gaggggaaat gatcaacatg aataattttg 2705401 ttattttgcc aatcctgatc ccgcttttgt cggctattct tctgattttc atgacgaaga 2705461 atcttatgct catgagaatc ttcagcacgg cggcatcggc catcgggatt gtgattagcg 2705521 gcatacttgt acagactgtc ttcacaaaag gcatccagac actcagccta ggcggatgga 2705581 aagcgccgta cggcattgtg cttgccgcag accaattcgc cagccttctc gttctcacaa 2705641 cagcgatcat cggtttattg gttgggcttt attccttccg ttctgtcggt gaaaaacggg 2705701 agcgctcctt ttactactcc ggcgttcagt tcttgcttgc cggcgtcagc ggagcgtttt 2705761 taacaggcga tttatttaat atgtacgtat tttttgagct tctgcttatt gcttcctata 2705821 tgctgattgt attaggcggc acaaaaattc agctgcggga atcccttaaa tatattgtgt 2705881 ttaatattgt atcgtctgcc ctgtttgtca taggggtcgg ctttttatac gctgtaaccg 2705941 gtacgttaaa catggcggat cttagcgtga aaatcagcga atcaggacaa accgggctga 2706001 tcactgtgat tggtgtcctg ctgcttttgg tatttggcat gaagggcgga atcttccccc 2706061 tctacttttg gcttccaggc tcttattacg cgccaccggc ggcaatctcc gcgttgttcg 2706121 gcgctttgct gacaaaagtc gggttatatg cgattacgag ggttttcaca ttgattttta 2706181 ttcacgatac agcctttacc catcagttga tgatttggct ggcggcgctg actgtgattt 2706241 ttggtgtgat cggttcactc gcttattcga atgtcatgaa aattgtgatc tataacatta 2706301 ttaccgctgt cggcgtgatt ttgttcggtg tggcagtaca cacccccgca tccattcagg 2706361 gcgcgatcta ctatctgatt cacgatatgc tgattaaggg cgctttgttc atgctggcag 2706421 gtacgctgat cgcattgact ggaaccgcga gcctgcataa aatgggcggg ctgatcaaac 2706481 gctatcctgt tcttggatgg atgtttttca tttccgctat ttctcttgca ggcattccgc 2706541 cactgagcgg atttgtcggc aaatttaaaa ttgcagaggg cggcttcgca gaaggtgaat 2706601 ttacgatatc catgctgatt ctgctttcga gtctgcttgt actgtactct gtgctgagga 2706661 tctttataca tgcgttttgg ggcgaagaaa aagaaacgcc aaaaccaaat catcgaacag 2706721 ctaaaggact tctttatccg gcagctattt ttctcttgct gtcccttctc ttcggattgg 2706781 gtacagaatg ggtgtcgcct tacgttgatc aagcggccga gacgctgctg aatccggaaa 2706841 aatatatcga agctgttctg aaggagtaga tcgcatggca tttcaaattt tattaaatgt 2706901 gtttctcgct ttttgctgga tgttcttaag caacagtcca agcgccgcag gattcattac 2706961 aggctatatt ctgggaatgc tctctctctt tttcttccgg cgctttttca ctcgccagtt 2707021 ttatctatgg aaattgattt ctattatcaa gctctgtttc atttttataa aggaactgta 2707081 ccttgccaat gtcagtgtga tgaaatcagt cttatctcca aaactgaata tcagaccggg 2707141 tatttttgct tttaaaactg aactgacgaa ggactgggaa atcaccatgc tttctctgct 2707201 cattacatta acgccgggaa ccttggtgat ggatatttca gatgacagaa caatacttta 2707261 tattcatgca atggatatcg aggatgcgga aaaagcgatt tttgacattc gggagtcatt 2707321 tgaaaaagcc atacaggagg tgagccggtg atgtttacgc tgatcctgca aatcgcgctc 2707381 ggcattatgg cagtgtctac ctttttgtat gtcattcgtg tcattaaagg tccgactgtg 2707441 cctgaccggg tcgtggctct ggatgcaatc ggcatcaatc tgatcgcaat cacggcgctt 2707501 gtctccattt tgctgaaaac aagtgcgttt ttggatatta ttttgttgct ggggatttta 2707561 tcgtttatcg gaacgatcgc attttccaag ttcctggaga aaggagagat tatcgaaaat 2707621 gatcgaaacc gctaaggtcg ttgtggctgt attcattttg ctgggtgctc ttatatgcct 2707681 cattgcttca tttggcgtac ttcgccttcc cgatgtgttt acacgcgctc atgctgcttc 2707741 taaaggctca acattaggtg tcaatatgat tctgctcggt gtcttcttct atttgtggtt 2707801 tgtgacgggg gagctctccg ctaaaatcct gcttgggatt ctctttatct ttattacgtc 2707861 gcctatcggc gggcacttga tctgccgtgc tgcgtataac tccggcgtca agcttgatga 2707921 gagaagtgtg caagatgact ataacggaat cagaaacttt gtgattaaac gaaaagagga 2707981 ttcttattta taaaaataag cagccggaca ggcagagttc cggctgtttt tttatttctt 2708041 gatgacagcc agcgtgcatc tggatataca gatcagcctc tcttgctcgt catatatgtg 2708101 aatatgatag acaatcgtcg ttctgcctat atgaacgggc tcggctatcg cctttaccgt 2708161 tccttccttt acagatttta aatggttggc gttaatctcc aaaccaacac aagcttgcgt 2708221 tgtatgatca atcaggttct gtgcacctgc gctcgccgcg gtttccgcca gggccactga 2708281 agcgcctcca tgcaaatatc cgaacggctg taccgtccga tgatccaccg gcatgaccgc 2708341 aacgcatcgt tccgctgtgt tttcaacaat ctcaatacca agcgcttcaa gcaatgtgtg 2708401 cttcatatcc atctctacac cccccaacat ttaaagtaca ccgtctgatt tcgcaatcaa 2708461 aaccgcttcc gtccgtgaac cgacattcag cttattgaaa atcgatgtca agctgtattc 2708521 aatggaccgc ttgcttaaat gaagggcatc tgcgatttct tggtttgtaa atcccttttc 2708581 aacttcttga agaatcaggc attctctagg tgtgagcaca tcttgttctt tttgagagga 2708641 aggagccggc tttgtttttt gctgagtcat cagctgttta aagtaagcaa aatcgactaa 2708701 aatttctccg ttgagtacgt ggtatatgta ttgggtgatc ttttctttag attccgtttt 2708761 gctgatggca ccgtgcagac ccgcacgaat cgcttcctcg aaataatcct cgacctcata 2708821 accggtatac acgataattt tacaatgagg attctcttgt aaaatctgtt tagaaagctc 2708881 catcccattg acctcgccgc ctagattcag atccattaaa atgagatcat atgacgagaa 2708941 atcatgctgc ttgataaact gttcgctcgg ttcaggactg agacaatcaa cagacaaatt 2709001 cgaatccgtt tccaaaattg tcttggtgcc ttccatgaca gccggatggt catcaatcac 2709061 tagtatcttt ttcatgtttt cctccctttt actcactctt ttccatttta taaaaaagac 2709121 ttggcctgtg ccaagtcgtt tccgttataa atccattaca attcgatttc aatatcagcc 2709181 ttaaagccct ttccttcact tgtttcaatc cgaaggcgcc catctaaagc cctgactctc 2709241 tccttaatgc cagaaagccc catgctcatg gaatgctcag tatttttttc ttgatcaaac 2709301 ccaacgccat cgtcctcata atgaagaacg attttgtttt gaatactgat gagcataatc 2709361 agcacatccg tcgcctgaga gtgcttgacc gcattagaca gaaactcttg aatgatccgg 2709421 tacaaattca gctgcgaatc cagatcaagg gaagccgtaa atctcccggt atttaaacgg 2709481 atatgaaacg gaacccgctc ctgctgctgc gccaccagct tcgacagcgc cttcaccaat 2709541 ccaagatcat acagaagctg cggccgcagc tcatgacacg tctccctcgt catcgaaatc 2709601 acatcagaca tctgctcatt catctgtaca agcttgtcct gcacctcttc acggcacgga 2709661 ttatcatcct tcttgaaatc acccaaaaac agctcacact ggcgttttaa ggaaatcaaa 2709721 tcctgaagaa ccgaatcgtg gagatcgcgg gcgagtcctg aacgctgttt ttcttcgatt 2709781 gcaaacatta gctttttcag ccagatgggg ttggttccct cttgttttaa gtccttcaaa 2709841 tgttccatga gctcctcaat atgcaggaca ttttccatgg acacacttgt ataaaaagac 2709901 agtgttttca gccacgatat ttcatcacgt gttagccggg gagtgttaat attagataaa 2709961 caaagcagaa cataagaact accgcctcgt tcaccaactt tcataagaaa gccttgattg 2710021 acttctataa ttttcccaat ttctgaagtt acgttttcaa attcctcttg ataaaaattc 2710081 cagtccggtc caacttcatg cttatctaaa aatatcactt tgtgatcagg agtaacctca 2710141 aaggtataag ctttgcttac aagcaaaaca tccagtatag tatttttcag ttctttaaaa 2710201 acttgttgaa gagaagttac acccctcatt agctgagtat atttaaaaat actgtcctga 2710261 tagttgaatt tttcggagaa acgttttaac cgaaatttaa aatccatgac ctctttaaaa 2710321 taaaagacag cgaacatgac aacgaaaaaa aatacagttt gacgcacagg gttcatctgg 2710381 atgtccatta catcaaacag aactaatgca ccaactatta gaagagttgg tatcatggca 2710441 agtagagcat agtatctcat tcttcctaag ataaactcta tatcaaacat cttattggct 2710501 acaaattggt atactaaccc gaacggaatt agtactagta atgacgccga agctaatgcc 2710561 gggaaaatat aattacctgt aaatattatt ggaagaacaa aaaatatcaa aaaaggcgca 2710621 aatgaaagag tgtttgttaa aattagtaat ttaagaataa acgaatgctc agcatattta 2710681 tatttattaa gatgtaagta tatcgctgaa aaagaaaata gagtcaaagt tgcaaaagaa 2710741 accaaattaa gagttgctaa aaaatcaata tctacttgta aatagtcttg aaaaaactca 2710801 ataccaagat taaatattgg tatgatataa agaaaagaaa ttctattcaa aaaagtttta 2710861 cctatttctc caaggtatct ttgtataaat tgaagataaa gaataggaga agatataaaa 2710921 gtaaacaagt taatataccg attgattata tgtcctctaa atggtccgcc tgcacttata 2710981 tatgctatcg aaatgtctaa taacaataga ataagaatat aggcagcaaa tgatctcctt 2711041 tttttattta ctttaagtat ataaaaaata catattatgc ttaaaaaata aaaaaacaaa 2711101 ggaagtacga acagaaaaaa actataaggt ctatttagag taactaaatc aaaatctttg 2711161 agatgaatct tttttccact tctcaaaata tccagactgt taatatgact caaatatccc 2711221 catttcaaat gtttgtctga aggtttttct ttattaattt ttaatatgat gtctccctgt 2711281 ctcagaccaa caaattgtcc atatgaagat tccgatattt cttctatcat aaattgactt 2711341 ttatcatttt tatgaatctt agtcccaata ataattccat tcatactgat ataagttgta 2711401 tagcttatat aaaggatact caaaacaatt acagctattg tgaatttttt tattaagttc 2711461 ttcaatatta atccacctat taatcacccc attgacgggt tattggatca gccagataat 2711521 aatcattata agctttaatt attgtttcag tttcttgcac atcaaaacct ataaggcagg 2711581 cttctttatt tttcaatttt tttaaagcct caggataatt taaaaagtag ttaattaggt 2711641 cttgcatctt gtatccccct ttgtataact taataagcat tcctttatta gctctttttt 2711701 tctttatcta aatttaattg ttctatagca gaaatacatt tctgtttata tatttccaat 2711761 aataccgaaa tgtattgagt aactcccgct ttaattaatt tttcttggaa tttctcttta 2711821 tcaagtaacg atttataata taagtcttta tgtgaaatta agtataataa atcttccgaa 2711881 gcatcattaa aaaggcgctt aagatataag taaatcagtg tatgtttgtt tttttcaata 2711941 tcactgcgat ttccggataa aagaacataa taatctccag aaatttgagc tataatccct 2712001 ttatagtagg aatatctttc aactgtttca ttatattctc ctgtagccaa taaaacacct 2712061 gctacatttg ctagtgcaat cagacttcca cattttaatc taattacttc taaactttca 2712121 tcttctgttt tagatttatt agtgatatcg tcatgttgac cttgcatggc ctcgtttacg 2712181 tattttaaaa catatttaaa aattagagga ttgttattta atgaataaat actcgttaat 2712241 cctactgtat acaaggaaag tgctgcattt aacgactccg agcgattaat tttcatccat 2712301 aatgcatggt gattatcttc atcttcaaga tcatccataa tatctgatga aagaataaga 2712361 atttctattc ccgcgccaag ccttgttgca acatctaaat tctcccctcc aaaaacaaca 2712421 taatgtaaga ttgtggattc agcaaaggag aatgtttctt tagaatcaat aaatgagtaa 2712481 agaagttgtg acaaatcctc gttaaatatg ttttgctcca caatctcctt cattttctcc 2712541 ttgatccgga cagaatctaa acatatctgc tcaataacga cttcccccct cccattccat 2712601 tttactaaat gggacattta aaggacagca ggtttttcgt tttttaacaa tcatataata 2712661 ctttatccat ttattgtatc ggtagaacga aaaaaaagac ttgtttccaa gtctttttca 2712721 cgaaattttc attgcataat tgtatttatc gagttgatca atgcttttgt taatgtttcg 2712781 taatgaatct gtcgtttctt taatatcaag ttcgagtcgg aataacaatt gttttacttc 2712841 ttcaagtttc ttttccatcg tttccacact cctttttttg aaagatcaat gaattgtgta 2712901 tggtgaacga gtcctaggta tttgatctgt tactaatagt gtgtctgctt tcggctcatt 2712961 tttcaccgaa aagtatgcaa aaaagtcctg cgtgacaccg caaatctcaa taggtcctta 2713021 tactcaaagg aatcacaaca agaacgggac tatctttcta tgcgaaagag cgtttatatg 2713081 tgctgaaatt gagaaagatt cttaatctcc ttgattttaa cgggtttcgc attttcacta 2713141 agcaagacta tagtccttca taccgtattt tcaaaattga atatgcgatt cttggcgttt 2713201 cctgaccgac aaacaccgaa aaagaccgca acgctaaagt tgtggccttt tcgctttgtc 2713261 atattcggca attagggatc tatacatata gaaacatcct tttttgcgag gtgctcccat 2713321 gagatatcgt tatccctggt tttacgtgta tccgtatgag gtacgccgtc cgcccgctcc 2713381 tgccaacaat attgatacct ttatccgttc agcgaagcag gccgcaggga tatttgcgga 2713441 tgcccagctc gttctcagcc gcattgcggg ctcgcgggag ctttcgcgcc gcattctgac 2713501 cgcagccgaa cagtctgata aacaaactat aaggcgcctg atcaaacaaa tgggcgtccg 2713561 gcatgaagtg gatacggtct ttaatcccga cggcatctat atcagcctta tcggaacgca 2713621 aagccgaatg attcttgctt tgcggtggtc agaggaccgc aatcattttg cgtccataag 2713681 attatgacac cattccagag cctctaaata acattcatac gcttcttctt tgtccagttg 2713741 attgcctaat tctgagcaag tgtcccagtt gttgctttca attaatttca caagctcaag 2713801 catttggtag tagtcgtttt gatggcctaa taatgcttgc ccgacttcat cttttaaagg 2713861 caattcttga acaatttcct ctatttctct atgcaggagg gtgtctatga gagaaaacat 2713921 tccgatcagc atataagaag caggctgcgg ccgggatgtc tttctcgcca gcagttcgca 2713981 aagctttgct cttatcagag aaatcttaat gatttcgtgc ttgctggaat gccctttcct 2714041 gcttaaatcc ttaaaggaaa gaatatatat ccaccgtttg atttcattaa atcccagcag 2714101 cataatggcc tgttgaatgc tttcaatttt ctggctcaaa cggctgtggg atgagtttaa 2714161 aaattttaaa atttgatagg acagtgataa atcccgctct atgtactctg tcacacgctt 2714221 tatgttaggc tgctctttac tcagttcgtt aagcagttca tagtaagaat agaaatgagt 2714281 cgataggtca tgcccgctga tgatgcgcgg ctcgctgaaa aagtagcctt ggaataattg 2714341 aaagccgtct tggaccgcct gtttatattc ttttcgggtc tctacttttt ccgctaaaaa 2714401 aatcaggccg cggcagccgt aggtttgcaa aattgttctg cgttccattc gtgttgtttt 2714461 gagaaaatca attttcaata tatcaatata gctcatgagt ttttccagta agtcctcatc 2714521 ttgcggattt attgcataaa aatcatcaag cgccagcata taccccattt ttttcaattc 2714581 tttgcatcta gaaatgaggg ccggcgtgat cggtatatct tcaaggattt caatgacaag 2714641 ctgtttcgga ttgaaggagg tgggaagatt cgaaaacatc aggctttccg taaaattaac 2714701 aaaacagcgt ttcccttccg tcagcttctc aattccgatg tttaaaaagc tgttgatcac 2714761 caaatctgtt gttgcctgat cgccgtcttt agcgctatac acgttctctt cgctttctct 2714821 atacagcagt tcataagcaa caacctgttc ttttctatta aaaataggct gtcttgcaac 2714881 aaacaccctc attgatttat cccccttaca atacgcgcgg ctttcacccc taagtatatc 2714941 aaataatttg acgaaaattg tctaaacatg aaaaataata tatacataaa gaaaactggc 2715001 ccttcgcgaa tgaaaggcca gtttttcttt attcttcctc aagctcttct tcaattctgc 2715061 ttttcacttc gtggatccgc tgcattttat tgctccagca gtcctcgctt aaatcaaccg 2715121 ggtattcctc cggcttgctg attctcttat attcctccca aagcaggctg aggttatcct 2715181 gcacatactg ctgtatgtct gaaatctcag ggttttggta gcaaagaata cccttctcaa 2715241 aaatcagttc atgaagatcc ttcgcataaa aattcgtgac aaatttgctg atgaatgtat 2715301 gaaccgggtg gaacattctg agccgcttct gatcattcac ctgctcatca taaagcgcaa 2715361 tatagtcgcc ttcagaatga tggttggact gattaataat gcggtagact ttctttctgc 2715421 ccggtgtcgt cactttttca ggattggacg aaattttgat cgtgtcgacc attttcccgt 2715481 cttcttcaat ggcaacgagt ttataaactg cgccgagagc cggctggtca taggcagtga 2715541 tcagcttcgt accgacaccc cagacatcaa tgcgcgctcc ctgagccttt aaattcataa 2715601 tggtgtgctc atccaaatcg cttgaagcaa tcaccttcgc atctgtaaat cctgcttcat 2715661 caagcatttt ccgggctttt tttgacaggt acgccaaatc gccgctgtcc agacggatgc 2715721 caatgaaatt aatgcggtcg ccgaattcct tggcaaccct aatcgcgttc ggcatgcctg 2715781 aacgaagcgt gtcatacgtg tcaactaaga agacgcaatc cttatgtgtt tccgcgtatt 2715841 ttttgaaagc tgtatattca tcgcggtaag cctgcacaag cgcatgcgca tgtgtgccgg 2715901 aaaccgggat attaaagcgc tttccggctc ttacattgct tgtcgcgcta aagccgccga 2715961 ttaaggctgc tctcgctccc cacatggccg catccatttc gtgcgcccgt cttgttccga 2716021 attcaagcgc aacttcatca ccgatgacgc ctttaatccg ggcagccttt gttgcgatta 2716081 atgtttgata gttcacaatg ttgagcaaag ctgtttcaat cagctgcgct tctaccaggg 2716141 gtgcctccac cctcataatc ggctcattgt taaaaacgag ttctccttct ttcatggagt 2716201 aaagtgaacc tgtaaaagat aagccgcgca aatattcaat aaaatcttca tgatacccga 2716261 gttcatcctg taaataactc aaatcgctat ccgtaaactt gaaattttcc aagtattcaa 2716321 tggctttttc caagcccgca aatacggcat agccattttc aaacggaagc cttctgaaaa 2716381 acagctcaaa aatcgctttc ttttcatgaa tgccgtctct ccagtacgtt tccgccatat 2716441 tgatctgata aaggtctgta tgtaatgaca ggctgtcatc tttaaatccg tactctaaca 2716501 ctgtttttcc ccttccttac tctgccactt gcgctccgat gctgtttgca aaatgggaaa 2716561 gagcccatgc gtgcccctcc tgattaaagc tggcaacagc ttgtttatgc acaacaatcc 2716621 gaaaaccttt gttgtatgcg tcaacagctg tatgcaacac acaaatatct gtgcagacac 2716681 cggcaagatg cagttcgcca atctgccgct ctctgagttt gagctctaaa tcagttcccg 2716741 caaaagcaga atatctcgtt ttttccatgt agtaaacatt aggttcatgt tcatgtttct 2716801 gatatagagg caaaagcttt ccgtacagat cttttccttc cgtgcctttt atattatgcg 2716861 gaggaaaaag acgggtttca gggtgatatt gatccccttc atcatgagaa tctactgcta 2716921 atacgacgta atcaccgttt gtgatgaatt ctttagttaa attgacgatc gcctcttcaa 2716981 tcattctgcc gggctccccg caggtcaatt ttccgtcact cgccacaaaa tcattcgtat 2717041 aatcaataca aataagtgct tttttcatag ccggcctccc cgccatcagt atgagaacat 2717101 tatatcttat ctccagttgt aagtgaattg ccatgaacaa aaagacaaac ggtccgtttg 2717161 tctcttacga tttcagtact gaccgattat aaatgtcgtc ctgaatatat atcaattcac 2717221 gattcacagc gatatcagcc gcaatgacga tgcctaaggg cgtatgaaac tggagatcag 2717281 atacaatctt gaaaggcact ccgtaccggc tcgccatttg gatataagaa gagtaagact 2717341 gatactgaag ctctccatta atcaaaaggg tgacgttatg gctgtttttc agctcgtgct 2717401 ctgcctcttt atacggtttg cttctaagca cctgtccttt cgtcagtgcc aaaacgactc 2717461 tttctcttaa agagcctaaa aacaaatggc gctcgtcagg ctttgtctcc aaaggcccat 2717521 acattccttg ctgcaaatag agatccattt tatcttcact caaaagcctg tcctcccgtc 2717581 ttgtttgtct tcattatcac ctgatcaggc aggagctaaa ctttcaagcg ccgtttacat 2717641 ttctgttacc caatgaatga tttttttggc cagctcacca gcaggggttt cctctgtatg 2717701 ccggcgcaac gacgcttcca gccgttcagg cagagttgct ttatcttctt cataggaaat 2717761 gatcgtgctc cactccagct gcggtaccgc tacaagcgtg cgcagttctt ttctgttttc 2717821 atgcagatac acgtccgtga tcattccggt ttgcgtattg atatttgctt ttctgatttt 2717881 cataacatga cctctctatt caaagactac ccatattata caataaaaaa gcaacagcct 2717941 cttgtgaaaa ggctgttacc cgttaaacga aactgtttca tcagtgatat cggcatcttt 2718001 gaagagagtt ttactcgttt ggttgttaat cttcacaaaa tcaccaagct gaaatgtgcc 2718061 tgaccccgcc cctgaatgag cgacgctttt gggcgaaatc gcaaatacgt ctccaaagct 2718121 tgccgcggca ttatccgtaa ctgacatgat ataaatcggc cccacaattg caggcatttc 2718181 cccacctccg cattgattta cagcatcata tgcaaggagc cgataatggt gcccgcctat 2718241 tcagctggct ttgcgttttc ctcgagtcgt gaccgctggc gcagcttgat caagcggaca 2718301 atattcagga agaacgcctt cactaccgca taaaccggca ccgctaaaat catgccgaga 2718361 attccgccga agcttcccgc tccgattaat agcaaaataa tcgtaagcgg atgggtattc 2718421 agccgctttc cgatcacaag aggagacagc aggtttccgt ccagctgctg aacgatgacg 2718481 accacaataa tcgcaaacag cgctttggcc ggcgagtcca taaaaccgac aatgacagcc 2718541 ggcgcggcac cgagaaaagg cccgacatag ggaatgatat tggtaatcgc catgacaatc 2718601 ccaagaatca gggcatacgg cagtccggca attaaatagc cgataaaaca cgctgttccg 2718661 acaaaaagac agattaacag ctgcccctgg aaatatgccg caagcgtatc ggataaatct 2718721 ttaaaaatct ttaagccttc tgtccgataa gaagccggta gaatttttac tgccaaatgc 2718781 ggaaagcggt gtccgtcttt cagcatgtaa aaaaggataa atggaacagt aataataaca 2718841 agcgtgatgt ttgtcacgac accaaacacc gcagataaac tggacgtgat attttgcggc 2718901 aggttttgga gaaaacttgt caatgactgt tcaatttttg atatcgatac ataatcctgg 2718961 ttcatcatcc aggtaaacca ttgagaatgg gacaaatcct ttgtcagcgc ctgaatctgt 2719021 tttatataat caggaaggtt gttaaacagc cctgtcacct gtgcggtgat gataggtccg 2719081 actgacgctg aaataaaggc aagcaaaccg ataaacagta aatagatcaa tagaatggat 2719141 aatgtccgcg gaattttttt ctcaagcagg cggacgaccg gattaaatat gaaatacaaa 2719201 attcccgcaa ttagcatcgg gaaaaacaat gtcgagataa aaacaataaa cggctgaaat 2719261 acaaatgaaa cttttgttgc tacaaaaata atcagcaaaa caaataaaat ctgcaatgtc 2719321 caaaaatgga cttttgattt caacaagctt tgttcctcct agtttttctt tgtctgtcag 2719381 ataaaagaac ttatacccca tcattgtaac aaaaatgaac tcatatcaga actcttaata 2719441 taatgaaagg agtgttggtg atgaaggccg tgacatacga tacagattca gaactggctt 2719501 atatctatgt tcttcctccg aaaaagaaca ggaatgtacg gactgaggag ctcagagtca 2719561 atgattgtct cctgctggat atcagccaag atggcaaaat cgccggattc gaatgttttg 2719621 gtgaggcagc acacctctgt gccccatttg ccgggaaatc ccggctgtat gtaaaagatt 2719681 cagacggtta tcattttcgg gtctgccagc atgcttcagt ccgttcctgc tatacggtgt 2719741 accgtgtcac tttctgtttt tcagatggtg actatcagga atttgccggc tttgaccttg 2719801 atggaacaat gtatcatagt gcgtttttac agcgcttaac tgaaaaatag gacgtcctgt 2719861 tgtacgccta tttttcatgc gcaagcactg ttagacccgc tcactgtaat ctggggtgac 2719921 ggaaatcatg tgctggattc tgatcaaaca aacagaattt cgggctcctt caattgtgat 2719981 atggtcaggt tttacatcga tcagtctgcc tctgaccgta tctcgtactg tctgtataac 2720041 gaaccttgag ccgatgagct ttttaatggt ctgatagaca taaggatcga ctaaagagac 2720101 cagttgcgga ctaccttggt tgaccatact tttatcccct ttgtgtgttt tatctcagct 2720161 tatgccgcgc ttatggataa tgacacaggc ttacctgata aaacaaaggg gtgcggagat 2720221 tttaggagaa tacgtttgga ggcgggtgta aaggaagtat cgatgaagcg gagacagcga 2720281 agaaagctgg cgctgttccg tacttataca ggctttatca cggatgcctg ggcttggtcg 2720341 attaattggt ccagcttttc tatttttttt cgtgcggttg aaggatcaat ttggcggtaa 2720401 tgatggtggc cgcccggctc ttcatccagt tcgtccgctt ttttgacaat ctgctgcagt 2720461 gtgtttttat ctaattcgcc ttcaggcaaa taggaatctg tatgaagcaa aatggctagt 2720521 gcaatctctt ttgctgcttt cggttcctcg ccaagccgaa tcagaagttt atgcgcccgt 2720581 tccgcccctt taatggcatg aatgtcattt cttttgtatt tctcataatc ccactttccg 2720641 tctgtatacc attcataatg gccaatgtca tgaagcagtg ccgcttttgc tgctaaatca 2720701 ggattaatgt cagccttcac agacagcctg tatgcatgat aagcgcaggc aatcgcatgt 2720761 gccacgccgg aacgctgaag atatttttgt gcaattggat gggtgaaaac atccattaat 2720821 gtaacctttc tcatggaaac ccctccttta gatattttta gaatcctaac ataatttgca 2720881 gagaaactca attcttatgt cacatcattt tgatcttctt atcatcattg ttatacccta 2720941 aaagcaacgt ttcagtcagt atatgcggct gttcaataaa atgcgctggc tgcagccttt 2721001 tgtataaaaa aaagagcaga aaatatctgc tctacaaaaa ctctttaata tcataaatgc 2721061 ggccgttttc cgtccctttt tctagtaaag aaagcagcgt gccggcaata aagtccggac 2721121 tgcgaaggct tcctgtttca tttaatttcc ggaatcgttc aatgtggtgg aaatcctttt 2721181 tcgatgaaga acggatgacg gcctgcatct cagtgtccat cactccaggt gagaacgaaa 2721241 tcatgttcac cggcagctct tcatcctcct gttcaaatcc gaatgtcctc gtaaacatgt 2721301 cgagcccggc ttttgaactg caatacgcgc tccatccctt atatggattt ttggcggctc 2721361 ctgaagtaat gttgacaacc gtctttttgc cgctgtatga agcaaaccgt tttgtaaaca 2721421 gctgactcaa aagcacgggc gcagtcaggt tcagctgata atggcgctga agctcgtcaa 2721481 gagacgcttc gccggcacgt ttgatcggcg ttaccattcc ggcgttatta ataagggtaa 2721541 taccagaata acgatctgaa tcgatggatg agagcaatgt ttcaaattgc tgttcagctt 2721601 cttcgagatt gatgaggtct atttgatgct gcgttagttt tttgtgagag acatctgttt 2721661 tcgttctgga taaggcatgg acttcatgcc ccttttctaa agcctgtaat gcaatggctt 2721721 gacccagccc ttttgacgct ccggtgatga tataaagttc cattggaaac ctccttttcc 2721781 gttattattg tacggcacct cttttacaca acacaagcac gcggcctacg ccttcttgtt 2721841 ttcctgcgct gtgacttttg ggatgaggaa cacgatgcct gcaattccga gcaggatcag 2721901 tacgacatag atcatcggca gcagcaatga tgatgtttct tgttcatctt ctgtttccgt 2721961 tgatgatgtc tttgtcattg gtttttcagc aaaagtaatt ccaagctgtt tcgactgggc 2722021 cgcaatcgtg ttggaatcct cggcatttgt tgatgtaaac aaatctttta tcagctcggc 2722081 gtccttgtcc ttcggtttat caaaagtgat atccttttgt tcctcaggca gttctgtttt 2722141 ttcttcatag taggtatctt catgcaaata attcgtatcg atttcgatgt cttttttctc 2722201 atactggttt ggcgcgacat ctgtattttc ttcagtttgg gcagccgctg cagagggtat 2722261 gaaaagggaa aaggagagca tacaaatcat gatccccttt tccatgctgc gatcacgctt 2722321 catacgtttc atcgctttct gctgtgtgtt cagccatcaa ccggataatc agcggcagag 2722381 ccacggcaat caccgtaatg atcagcagaa ctgttattcc cattgtaaac aagtgcccag 2722441 taccgtactg gatgtcgata tatactttcg aaaccggatc ttcaaatgta aagttcggca 2722501 tgatcaaatc aataagcggt gcgacataga ataggatcat tgctgctgaa gcaacccagc 2722561 cagggattga tccgaatctg aatgccgtcc ggatgaaggc agagcttgcg accagcaata 2722621 gaatcgtaaa caccgaccac ttaatcgtct gatcgtccgg cagtgaataa atattcaagc 2722681 cgaacaagct gatcataagt ccgacaagga tattcagaat tccgaataac gctcctttga 2722741 cgagaagcgg tgcgttttgg taatacgagc tgaaatagcc gattaacaga ctgctgatca 2722801 acacaatgac aaggatgaca accggaggta ccgtctgaat tttttcttcc ggaacctctc 2722861 cgctgatttt aagcggattc gctaagtaat catatacata gccattgttt tgcccgtcta 2722921 ctaatgtatt tccgagtatg ccgtatacgt catttcgcac gagtttcgtg gaggcgacat 2722981 ttttccccca gttgttgttt aaggtgtcgg ctttcgcttg aacatcatta acgctttgct 2723041 gcatgttggt tgtgtaatca atgatgccgg actggcgatc agacaatgaa cccatcatgt 2723101 ctgacatttg cagcacttcc tggccgaccg tatcttggac actcagtgcc atggtaccag 2723161 acagcccatc gttgctgaac gtcgcagatt cctgtgttgc gcccgttaca agctgttctg 2723221 acgcttttgc ggcactttca gagattttcg tcagttcgtc gagaacacct gcttgagagt 2723281 cacggatata gccgctgtag tcgtccgcaa atttggtcat gccgtcgatg aagctgttaa 2723341 tatcctcatc tgtttgcatc gtgttgtttt tgagagcttc ccagctggct gattcttcag 2723401 gtgtgagagc caggactgat tggacgttgc catcttgctc ttggatgact tcacctttaa 2723461 taatagtcaa agagcctaga tccagattat catttagcgt agacttatat aaatttaaag 2723521 agttgtaata cttcatcaag ttagaaatat tatcagtttc aattctactt gaaaaaattg 2723581 aacttagttt ttctttctga tctatatagc ctctactctg caaagtttgt attatttcgt 2723641 cttccaaatt gtatattaac ctataagcat cattgacatt attatcaaaa tcaaccaact 2723701 tttttgttaa gtcaccaatt tgatcattta attttgaaac tgttttattt aactctttaa 2723761 tttcttgatt taactcatca atatgtttct ctagtttgtt gttatgttcc tcttgttttt 2723821 cttgaagtgc attttctatt tcctctaatt ttatcgctgc ttcgttcaga cgtttttttg 2723881 cacctgaaat atcagtttca ccgtcagctc cgtcaccctg tagcccatca ctttgatttg 2723941 agccatcgtt ttcatctgcg agttcaatca aagagaaatc tgttttagag gttcctgtat 2724001 tctccgtgtt tgtatcttgt tcaggaacgt tttttgaaga ttcttgatgt ttttgtcccg 2724061 tttcaatgtt agtttgaaca tcattttgtg atccattatc ttgagtaccc tcttctgatg 2724121 agccagtatc ttcatttgtt ggctgatcat cggatgttgg aatatcattc gacggttctt 2724181 cagtattagg agaatcatcg gttgatggtt cttcagcatc gggtgttgtt ggtttttctt 2724241 gttcaggttc ttttaaccct tcagagatat ctttaatttc agttgcaaca tttttgagct 2724301 catcccgctg cttctctaaa tccaatttta tatcttcaat atcttcctta tctgtgtcat 2724361 ctttattatc agatgtgtct tctccatctt ccttttcgtc gctttcctta ggtttaagta 2724421 aactaaggcg gttcttcccg atattctctt gcaattgatt taaattttga tatttaatag 2724481 cttcatattg acttttatat cgagatagaa atgcattaaa catgtcattc tcaatttttt 2724541 tcatacccat ttcttgcaat ggcacttgat tttgccttaa cttttcagca ttgttcaacg 2724601 caaggtttgt cagtcctatt tgtgtcttcg cttggccgat cccggttgcc aatccgctca 2724661 tgcgttcgct gaactgattc gccttttgct gtgcctggat ggcatccaga cctgtccgga 2724721 tttgctgctg tgttgaatcc tgggctgcca aaagcagctt tttctgattc tcttgatatt 2724781 ctttgtacct ttcaactgta tcaatgaatt ctttcagcgt gtttttggct tcctccgccg 2724841 tagaagcttt ttcttttgtc gtgccttgcg cttcattcat tgatttcttc agctcatcga 2724901 ttaagtcttt ttgctgtttg atttcacctg ctaaatcatt agagcttggt ttgtaaaagt 2724961 tgtacatgac attctggaat tcagattctt tattgacgat cttgtcaaat tctcctctga 2725021 tgttgtccac tttttgcgaa acaaaattcc agtataaggc cgacattttt ttgttcattg 2725081 tcttttgggc atcctcaagc tcacgctgaa ctttttcttt gttaaccgca ttcaggttat 2725141 cttgaatgct gaattcgagc gttgcctttt gaggatggtc tttgtcatag ctcaaaatgt 2725201 tttttgagaa gtctgaggga atgtagacaa tcgcatcgta tttctttgaa gcgagaccgg 2725261 tctcggccgc gcttcggttt acgaccgtcc acgaataatc aggacgttca cccagaacgg 2725321 ccgctacttc cttgccgaac tgggcggatt tgtcctcttc atcagacttt acctcatcac 2725381 tcaatacgcc tgtgtcttca ttcaccaccg cgatttgccg ggtagaattg actgcttttt 2725441 tcgttgggtc gtctccgata aatcggaaaa acaacaccgg cagcagcaaa atgatgatga 2725501 cggcggatat taacttgatc aagctttttc gttgttctgt catctagcac tctccctttc 2725561 agcagaacat aaaggaattt gaactttttg ctccttcccg ttttccacaa catatccgaa 2725621 gcccggctga atctcaggct cctgtctttg gtacgggaga ggaatgacat tttgctcaga 2725681 ctttttcatc agcagaatcg cgtggcggat ttgcttcatc tcagtcgtca aggagtcata 2725741 gccttttgag aattcgctgt ggtttccgcc cgggataaag ctgaacccaa gatgagcgta 2725801 tgatttcatg aagttagcga gacgatcttg tattctcgta tcaatcgtct gctggaatct 2725861 cgttatcccg tcaatcatca gcacgacttg tgagaatcgc agattttgtg cgtctccttg 2725921 gcggacggct tctacataca tggcttctct tgttttgaaa atgtcttctg ctgtttcaat 2725981 ccactgctca atatcttctt tcgtttccaa atatgaaaca tctgattcct tcgcataatg 2726041 agataagccg cggtcaatcg agtcaaacag gccgatcatt tcggtttcat catcaatcag 2726101 atgttcaagc atgactttta ggacgtttgt tttcccgcgc tgagtttggc ctaaaatcag 2726161 gcagtgctta tgcttgccca aatcaaaata gactgggctg actgtttctt catgaagccc 2726221 gatcggtaca gataaaggct tgcgttccag cttgaagcgg atagacaatt ctctcgtcga 2726281 caagctctca ggcagcatcg gaatcggtgc cggctgctcc attgaagcaa atcgcccttg 2726341 aagtttctgt acgtctgatt tcagctcgtt gaacatgccg atatcatcat cggcgtcaac 2726401 aggcaggaac atttgcgcga aataaagctc ttccttttga atgatgacgc gtcccggaat 2726461 cggctcaaga ttgaatttcg gacggccgta aatggaatat ccttctgatt gatccatgag 2726521 ataatggaca atctttgttt tcaagttatt taacaatgac tggcggacag cattcacccg 2726581 cgttgctgtc agcataaagt agatacccaa gctttgtccg tctctggaaa gctggacaaa 2726641 ttccgattca agctcatgca tctcatcctt gacaatgtca aagttgtcaa tggtgataaa 2726701 aatgaatgga agctcttctt cgctcagcgc attgtacatt ttgatgtggc tgatttcttt 2726761 ttcccggaac aaacgtttac ggcggtcaat ttcttctttg atgcgaatca tgaacttttc 2726821 aattttcctt gactggtcca tcaggaagta atccgcggta tgcgggagct tcgctaatgg 2726881 cagcagcgtt ccgtttccga aatcaaagat atagacatga agctcttcag gtgtgtatac 2726941 gtccgcaaaa ctcatcagga acgttgcggc tgcaatcgat tttccgtagc ccgaagagcc 2727001 gaagatgccg atatttccat cttccatcat cttataagca attggcgcct gtctttgcag 2727061 atcaggttca tcgacatacg caaagtggaa atggtctttt tcgtttgaag ggaaaagagt 2727121 gcgcggaata cgttccgcaa gcggcggcag ccaagggctt ggcagcttct cgattcccat 2727181 ttcatcttgg atgcgttcaa tttcgtcaac tacagcttcg atttcggttt gaacgtcttt 2727241 tttcgcgtta tcttcggtat caacctcaga aagcgggatc agacccgtat ctgtgacgat 2727301 cgcgatttca tcctcggtac cgtagacttc ctctaagtaa ggcgccccgc tccatgcaga 2727361 ttggaacagc tcatacactt cattgtttcc gacctgcaaa tagccgcggc ctgttacggt 2727421 aatgtttgcg gcatcgctgt ttttcaaaat ttctttactg tcggtggcat cctggacctt 2727481 gagcgctact ttaaagcgcg agttactcca gatctggtcg tcgatgatgc cgcctggctt 2727541 ctgtgtcgcc aaaatcaaat gaacgccgag gcttcgtccg atacgcgcgg cactgacaag 2727601 ctccctgata aaatcaggct cctcgctttt cagctcggca aactcatcag aaattaagaa 2727661 caagtgaggc atcgccactt ctgctttccc ttgcttgtat agctttgtat agtcattgat 2727721 gtgattgact tgatactggt caaacaggcg ctgccttttt tttagctcgc ttttaatgga 2727781 agcaagcgca cgcatactga agtttttgct tccttcaata tttgtgatcg tgccgaggag 2727841 gtggggaatg ttacggaacg gctgcgccat tcctccgcct ttatagtcaa ttagtaagaa 2727901 agccgcttca tgcggatgaa aatgcactgc aagtgacaag atgtaggtct ggagaaattc 2727961 acttttccct gatcccgttg tccccgcaag caagccgtgc ggaccgtgtg ctttttcgtg 2728021 aaggttcaga tacacaatgt catctttccc tttatagccg atcggcactg acagcgactt 2728081 cgacgattca cttgtcagcc atctttgctg aatgccgatt tcttttactt ccttcgcatg 2728141 aaaaagctcc aggaacgata ccgtttccgg aatggaattc gtaatgccga cctggtggtt 2728201 cagcgtccgc agtgtgcgtg aaaaccgttc gttatcctca cgctgatgat gatcgagacg 2728261 gaacggaatt cttaccgctt ttttcttttg tattaaaatg tcgccttcat gctcattaat 2728321 gtagcggaca agagttgtaa tgttttccga caagctttcc tttgtttctg cagcgacaat 2728381 tgtcgagatg cccagatgct catgctgccc ttctaaatat tcgagaatga catgctcaga 2728441 gatcagctgc tgattcgtga tgacaaatac aaaatgcggt ttgaactgca gtttttcttt 2728501 gtcatcttcg agatcacgct ctctgatcaa ttcgtaaagt gaagacagga gctgatctcg 2728561 ggtttgctca ttataaataa atccttttgc ataaatatgg ggcatttgaa attgcggaag 2728621 ccacttcatc cactcccagt ctttatactc ttcttcatga aaaataaata cgaaacgcaa 2728681 atcgtgatag ctgttaaaga acgacagctg tccgattagc tggtgaatct catttttcac 2728741 aatttgtgat ttaccgacaa gccccatcgg accttctgcc aaatcgaccg tcaccggcgc 2728801 attacggata tctttataga cgcgttgcat gtgctgcgat ttctccatga ggtcatcgat 2728861 atcacgattc gccaagtctc cgccactcat attgatttca tagcttgacg gaactgttcc 2728921 cgtcccaagc cgcagctgga gataatcctt gctttcaagt gatttttccc agatccggtc 2728981 actgatttca cttgttaagt atttcatttg ttcaaatgaa ggaaagtgaa attcaagaac 2729041 ctgcttttgc ttttcagcaa gtgcctgaag ctctttccgc ttattgtcta agtaaagctt 2729101 atatacacgc tcccgttttt cctcgcgttt tttccgctgg tttttatcac ggaaatattg 2729161 cactgtcgag gtaatgagag tcatcataaa catcgccaaa gaaacgagta taaatatgcc 2729221 gcgcggctgg atgatggcaa ctacgcccat cacgatcagc atcacaagcg gaggcaggat 2729281 gacgagccac agccctctgt tggtttgatc gctctcctga gagggaaaac tgaaagaaac 2729341 gcggtcatcc ggcagatcgt ataccatccg cggcgttctt ctgtactgcg gatatttttt 2729401 ctgcatctct gtactcggtt tgaccgtttc tgttaacgct gtttcaaact gggcataatg 2729461 aacaatttct aaaaggtctt gttccgtcac cctcatttgc gtgaagttcc agaatatttc 2729521 atcccccggc ttgagcggcg tattggcgtt gattttctct ccgttcaaga agatcgttcc 2729581 gctttcaggg cggaccgacc agctgccgcc tgcacggagc aaagaaaacg tgctttgttc 2729641 tgcaaatgca aaatcttgcg gattcagata aatatctgca ttcgtttttt ctgaggaaca 2729701 tacaatttca tcccgatttc ccgtaaaata aacggatttc tcaggttcac tgcccgtcaa 2729761 tatcaagcgt atatcctgct gatccgtttg gagagtaaat gatatatccg tctcaatcgt 2729821 gccgagacaa tcatttccca ggaaaacttc gtattggccg ccggattcct ttcttttaag 2729881 agaaatcact ccgctattaa atggaatggt gctgatcgta acagaatcct tcacatcagg 2729941 ccctatggtc accggatgag acgacgggag gttagacaga tttaattttt gaacgttatt 2730001 ttggtaaaaa acccataata gactcaaatg gcgaaccccc ttacggccga atggcagcat 2730061 gcgatgacct gcgcttcatg tctcacgtta tttgtcatct tttttctcat ctttcttttc 2730121 tgtttctttt ttctcgtctt ctttttcctt ctgttcttct tttttcgctt tttcctcggc 2730181 tgcggctttt tcttctgccg ctttctcttc tgcttgtttt tcttcgtctg tttgtgtctg 2730241 ttcttcgctt gtatcgacta acgatgtttc agaattagac tgtttatttt cttgacgttc 2730301 tttttgggct ttttcaagct cactatttac tgaatcaagt tctttttgta tgtcttcatc 2730361 atttgtatcc tcagataaaa gctgctgttt atatttagct agggcaaagt aaatataatc 2730421 attgtattcc agcttacggc cgatactgat cgcttctttg tattctcctc gaccataatc 2730481 aatccaatat aagaaatgct gagggtctga ttgaagggtg actaaattat tttctatatt 2730541 tttggttttt gcactcccca ggttttcgac ctcaacatag gacgtcgcca gctgatactg 2730601 caccgattca ggcaggcttt ccgcatcgta cttggacagt gtgctgatga cttcactgta 2730661 ctgcttgttt aagaacgcac ggttgctgtc cactatcgcc tggtgctttg gctgcgcgaa 2730721 aaataaggcg tacatcgaat aaataagtgc cggtacaagc aaaacaatga gccccaggcc 2730781 gatatatcgc tggatgttcc acttctttct cgggatatgt atgtatgttt ttgctttggc 2730841 ttcgagctca tcaatatggg tttgaatcag ctcgagcaaa tcatcatagg attcagcatc 2730901 taatatcgcc tttgcctctg cggagaacgt cagcgtttca ttgaatttca ggtagtcttc 2730961 aaacgcaaaa gcgccgtcaa ctgccaaagc cgctgccgct ttcagctcct gccatactct 2731021 ttcctcatca cgctcgtaag gaggaatgct ttcttttact ccataatgga gaaaataagg 2731081 cgtaagccct ttatcgaata caatgttttc aggagcgaca atcaaattca gcctcgacag 2731141 attgtgctgc tgtacggctt gaacaagctg ataggcaaac tgccatttac tttttttatc 2731201 cttagctttc atgaagcgga atgctttata ggaggaggga ggttggattg tgatgattac 2731261 ttcatcatcc gtcacatcga tttctttatg aaaaaatgga tttatatctt tgatcacgtt 2731321 agcttcaaga ccgtcgagaa gctttatttt ttcccgttga aaggtaaatg tatagccggc 2731381 atctgttttc tcggcaacag cttctaattg gttttctaaa tatgattttt gttcacctga 2731441 cattcaacca gatcctttca taatatttca agccggtctc cgtttgtaat gccgcaatca 2731501 gacagcttgc attctccgga aaacacctta tccttgttca ccactctgat ccagtgccct 2731561 tcgcgcggag gcatagatac gctttgggcc tgccaagcaa tatcaattac ttttttcacc 2731621 gggtggtaat ctgacaatct gagatcaaag acactgccgt tataatgttt caaatctatt 2731681 gtaatatcaa tatacattta ggatcaccct tacatagaaa gagcgccgtc ttcttttgaa 2731741 tcaggcgctc cttccctttc atactgttat ccgcggattt gatttgcgat gtcttggtca 2731801 gtagactcaa gtgtatttgc tgtttgatca agctgctgat tcacatcttg aagcaaatct 2731861 gacattttga taaatgaagg tttgagctgc tcgtattgat ctgcgaacgc ttcgcttgaa 2731921 gcaccttccc acatgctttt caaatcagag atcattcggt ttaaacgatc aacctgattt 2731981 aatacttctt ggctttcaac gccgtattgc ttcgccatcg ctcttagctc ttcgggtgtg 2732041 acacgaatta atcctgccat attcctcatt acctcctgtg ccatcagcct aaatatgggc 2732101 taattcactt atttttagaa cgtcattatt ataaaaacag tttttcggca tagtcaaaca 2732161 aatatgtttt aattttacaa aatgagtcca atggtttacc ccgaatcact caaaaatgac 2732221 atatactgta aagtaaatag gtttattttc ttaatcttct cttcattctc cgaataatcc 2732281 aaaagaccca aataactctc caactcccaa aaaaaacctt tcagaaaatt tgatgctaca 2732341 gcaccatttc tgaaaggttc agttttttct ttccttaatt agtcttgcct ccgatgactt 2732401 tcttagaaga ttaataggat aagctgtcgt attatatgag acatacactg tcctgcaaaa 2732461 aggcgattac accgccaaat gtatatagaa cgtttctctc atgaaattgt ttttttgctt 2732521 ctgttctttg ttgttgattt tcacaaacaa caacaatcat aataaaagga aggggatgag 2732581 atgtcaaaga gaaatcaagc acgaaaagta gggagattta tgaccatgcc gaatgatccg 2732641 tttaaatata gttttgacag acttgaagat gtggctgatc atatcagcga cgttctgcgg 2732701 tgcccgatca ccatagagga tgttaaccac aagctgcttg cctacagtac acacagcgac 2732761 tgcacagacc ctgcccggac gtctaccatt attggcagaa gggtaccgga gaaggtgatt 2732821 aacaagctgt ggaaagacgg gacaattcct gctctcttaa aaacggacca gccgatcaga 2732881 gtcaagcaaa tcgatgaagt cgggctgagc aatcgcgtcg ctatttcgat ttggaaaaac 2732941 aagcaagtac ttggcttcat atgggcgctt gagatccaaa aaacattgtc cgatgaagat 2733001 ctgctgacat tgcaaatggc agcaaaagca gtgaaaaaca agcttctcaa acttcaaatc 2733061 agaaaaacga aaaatgaaga acgcagccaa gaatttttct ggaaaatgct gaccggacac 2733121 atccatcagg aggatgatat ggcggatggg ttccataagc ttggaatggc cgctccttca 2733181 gagttttccg ttatgatcat ccgcataaat ggcgagctga ctgaaaaaat cgaacagcag 2733241 ctgcaatatt tacaggaaac gacccagcag gtttacgtgc tgctggcgac cgtagattcc 2733301 aatgaactta ttatattaac ctcacccaaa acagatcatc cttttcaaga tttaaaacag 2733361 tttgctttaa gtacgcaaaa acagctgaag gagcggtata aaatagaaga cgtttctatc 2733421 gcttttggcg gaatatacaa ctctatttct tttgtctccc gctcctatca ggaagcattg 2733481 tccgtcttaa aaacgaagga acggttcgct gaagagacca aacatctttt cagcttttct 2733541 gagttaggca tttatcaata cttagatgtc ttaaatgaaa aacggaaaca ggcgggccat 2733601 tataattact cgctttccaa actggaacaa tatgaccggg atcaccagtc aaatatggta 2733661 gagacgctag agcgctttat tgaagcggac agcaacgtga ataccgcttc caagctgtta 2733721 aatatacacg ttaatacgtt gaattaccga ctcaagcgga tcagccagat cgctgaaatt 2733781 gatttgaaaa atgtgaatca aaaattcacc atctatttag atatcaaact tcggcacatg 2733841 gatttgtgaa atttcacaaa tccatgtttt tttattttct taatcaaaca aagaattttc 2733901 caaaatatca agctacacta aaaatatcac atatacagga ggagacagat atgatcatag 2733961 gggttcctaa agagataaaa aacaatgaaa accgtgtcgc attaacaccc gggggcgttt 2734021 ctcagctcat ttcaaacggc caccgggtgc tggttgaaac aggcgcgggc cttggaagcg 2734081 gatttgaaaa tgaagcctat gagtcagcag gagcggaaat cattgctgat ccgaagcagg 2734141 tctgggacgc cgaaatggtc atgaaagtaa aagaaccgct gccggaagaa tatgtttatt 2734201 ttcgcaaagg acttgtgctg tttacgtacc ttcatttagc agctgagcct gagcttgcac 2734261 aggccttgaa ggataaagga gtaactgcca tcgcatatga aacggtcagt gaaggccgga 2734321 cattgcctct tctgacgcca atgtcagagg ttgcgggcag aatggcagcg caaatcggcg 2734381 ctcaattctt agaaaagcct aaaggcggaa aaggcattct gcttgccggg gtgcctggcg 2734441 tttcccgcgg aaaagtaaca attatcggag gaggcgttgt cgggacaaac gcggcgaaaa 2734501 tggctgtcgg cctcggtgca gatgtgacga tcattgactt aaacgcagac cgcttgcgcc 2734561 agcttgatga catcttcggc catcagatta aaacgttaat ttctaatccg gtcaatattg 2734621 ctgatgctgt ggcggaagcg gatctcctca tttgcgcggt attaattccg ggtgctaaag 2734681 ctccgactct tgtcactgag gaaatggtaa aacaaatgaa acccggttca gttattgttg 2734741 atgtagcgat cgaccaaggc ggcatcgtcg aaactgtcga ccatatcaca acacatgatc 2734801 agccaacata tgaaaaacac ggggttgtgc attatgctgt agcgaacatg ccaggcgcag 2734861 tccctcgtac atcaacaatc gccctgacta acgttactgt tccatacgcg ctgcaaatcg 2734921 cgaacaaagg ggcagtaaaa gcgctcgcag acaatacggc actgagagcg ggtttaaaca 2734981 ccgcaaacgg acacgtgacc tatgaagctg tagcaagaga tctaggctat gagtatgttc 2735041 ctgccgagaa agctttacag gatgaatcat ctgtggcggg tgcttaattc acaataagct 2735101 tgcagaaaga tttctgcagg cttttttatt ttttaaaagg aaaaaagaga ccatttcacg 2735161 aattatgact atgaagttga tcataaagga ggattcatat ggctgttcag caatatggcg 2735221 tgttaaaagg catagtatta gacatgaagc gggaaacaga tgatgacagt cctcatttcc 2735281 aagtcaaaat gctcggtgaa gagaatacgt attacaggtg cgccatcaat gtgatgtcca 2735341 gttctgagga atctgaagta ttgtatttgg ctgacgatca gtttgattcg ggctcaatta 2735401 ccatccttcc gaacatgccg tatggatata caaggatcaa tgaagcaaac cgtgaagtgg 2735461 cactggatta tgtgcggggc aatttgtttg acccgcggga aatgaagcct ttgcctcatg 2735521 aaatcacggg acctgataat gatttaaatg attttattga aacctatatg aagaaagcac 2735581 aagatgagaa aacgccggtt tatatattcg gttcaaaatt cggccctgaa caggctgcag 2735641 ataaaatatt cggctttacc ccgactaacg gaatgcacaa tatccatatg aatcaaggga 2735701 atgcaatgga tacccgctgg aaaaaagaca acggctcttg gcatgacggg ggtattctga 2735761 ttcagtttgc agatcagtgg gccgctgtgt ttttagcgtt tttatcccaa tcttggtgta 2735821 ccgatgaaaa cggaaaccct gtcagagatt gtgatcatac ccaaacgtct gcgtaagata 2735881 gaaaaagaga ctgcggcaag cagtctcttt ttgataagat tacacatttt caacagtctt 2735941 taggctgttt ggcctcatat cgctccaatg cgattggata tagtccaaac aagcttcacg 2736001 ccctttttgc tcatgaacga ctgtccagcc gctcggcaca tctataaaac ccggccatag 2736061 ggaatattgg ccttcttcat tgaccagcac caaatatgtg ccatccgcat tttcaaaagg 2736121 atttgccatt ctatttctcc tcccttattt attcaactct tccaatttga cagcgagaac 2736181 cttgccgatt tgagccagag gttcaggctg acataaatct ttatgacggc agtcgatgtc 2736241 gatttgttca atctgtccgt taatataagg cttccacgag tcaggttcaa tcgggtcaaa 2736301 ccattcagga atgattgttg atctgaaaaa caaaacattt ccgcggaagg ttttcggctt 2736361 ataggaacct aaaatgccga cagaatttac atacgtattc ttcaaattta aaatgaccgt 2736421 ttcatccagg ctcgcaagcg cactgccgtc acggcgaaga atctcaatcg ccgcttcaaa 2736481 atctagcggt ttttccccta agctgtctgg atcatacccg cctaacgcca gaagggcaat 2736541 aagcgcttcc tcatcatccg gtgcctcttt tataggaagg aagtggttcg gataggcgtc 2736601 cagcatcacc aacagggata cttcttctcc ttgattttgc agctgggtag ccatcgcttg 2736661 aacgacattc ccgcccaggg accagcccag cagatggtac gggccttttg gctggaccgt 2736721 tcggatttgt ttaatgtaat cggcagccat gtcatcaagt gttttcggaa gctcctcgcg 2736781 ctgcccgatt ccccgtgcct gcaagccgta gatcggataa tctgttccta tattggtcat 2736841 caaaccggca taacaccagc tgagcccccc tgccggatga acacagaata aaggaggctt 2736901 gtctccgctt gttcggagcg gcagcagaac gtcaagagcg ctttggcttg atcccatttc 2736961 aagtctttca gcgagcccgg ctacagtagg tgcttcgaac aagttgccga tgctgagttc 2737021 aacgccgagc gcttcacgaa tgcggctcat gagctgtaca gcaagcaagg aatgtccgcc 2737081 taaatcaaag aaacggtcat caatgccgac acgcggcaag tgaagcacct ccataaagag 2737141 gtcacagaga atttcttcct gcggcgttct cggtcctcgt cctgtcactg ccgctgcgaa 2737201 atccggagcg ggcagcgctt tacgatcaag ctttccattc ggtgtcagcg gcaattcttt 2737261 catcgtcaca aaggcagcag gcaccatgta atccggcagt ctctcagcag catatctgcg 2737321 cagttccgcc gtatcaaatg tttcttccga agggatgaca taagctgcta accgtttatc 2737381 tcccggctga tcctcacgaa cgatcactgc cgcatcttca agctgcggat gctgaacaag 2737441 cgcggcttca atttctccca attcaatccg gaatccccga attttcactt gatggtctgc 2737501 acggccgaca tagtcgagag aaccgtcagc gcggaggcgg gccacatccc cagtgcggta 2737561 catccgggtg cctggaggac cgaacggatc agctatgaag cgttcagatg ttaaaccagg 2737621 ccggcctaga taacctcgtg ctaaccccgc tcctgataca tacagctctc cggcaacacc 2737681 cggcgggacc ggctgcaggc gttcatccag cacgtataca ccaagatcgg gaatgccgca 2737741 gccgatcaag ctgtttgccc gtaaagctgc catgcttcgg tctaattcga tatagctcac 2737801 atgcaccgtc gtttctgtaa taccatacat attgataagc tgcggtctat tttcagggtg 2737861 gcggttgtac caatcctcta aacggctgag ttcaagcgct tctccgccaa aaatgacata 2737921 gcgcagactg agtgcctgtc cgagatccgg ctgttcccgt tccgcctgca taaactgata 2737981 gaaagcagac ggtgtctggt tcagaacagt caccccctct ttgacaagca ggcgcagaaa 2738041 cgcttctggc gatctgctga cgtggtgagg cacgattaca agacgtccgc catgcagcag 2738101 aggaccccag atctcccaca ccgaaaaatc aaacgcatag gaatggaaca tggtccagat 2738161 atcacctgag ctgaaacgga accagtgctc ggtcgctgca aataaacgtg ttacattttg 2738221 gtgaggaatc atcacacctt ttggaacacc tgttgagccg gatgtataaa tgacatatgc 2738281 cgtattcaaa ggggaaagcg gctgagtcct atccttattt tttggattac ctgcagggta 2738341 cgtgtttagt ttctctgcca gctcgggatc atccagcacg attttcggca cgttttcaac 2738401 tggcggaatg tgatttgcag ctttagtgtt cgtcatgata aacgcaggct gtgcatcttt 2738461 tagcataaaa gcaattcgat cagccggata atccggatca agagggagat aagctgcccc 2738521 ggcctttagc accgccaata ggccgacagc catttccaac gatcggggca gtgccaatgc 2738581 cacaaattgc tccggcccga caccttcact aatcatcatt cgggcaagcc ggtttgctct 2738641 ttcattcagc tctgcatagc tcagttcctg attttcatat acaacggcaa tggcatcagg 2738701 acgtaaagca gcctgcttct caaattgctc tggcaaacat gcgtgcggaa tcttttcaga 2738761 tacactttgc caatcagtca ccatgctgct gtgttcctct ggcgcaagaa tatccagatt 2738821 tccgatttgc tcgtcaggat cagactcggc agcctccaac aggcgcatca atcggtcagc 2738881 aagagcctga gcagtttccc gtttgaaaag atcagtgctg tattcaagca gtccttccat 2738941 tccgtttggt gtcccgtcag caaggcgatc ttcactaatt tccagcgtca aatcaaactt 2739001 ggcagaaccg acactgttga ttcgcaggct gctctccata tcaggaagat gcagttcagc 2739061 gtccggtgtg ttttggaacg caagcatgat ttggaataaa ggatgcgtcg cacgcgaacg 2739121 agccggattg agcacctcta caagtctctc aaacggcaga tcctgattgt cataggcggc 2739181 cagattcact tcccgtactc tgtctagaag ctcacgaaag cttgggtcac cggacgtatc 2739241 agttctgagc accaatgtat taatgaacag ccctacaaga tcgcccagcg catcatcatt 2739301 ccgtcccgcg atcggactgc cgatcggaat gtcggtgccc gccccgagcc ttgtcaataa 2739361 agcggcgaga ccggattgaa gcaccataaa caggctcacc ctatttgcgc gagccagctc 2739421 ctgcaatcgc ttgtgaaact cgggctcaat acgaaaatga atcgtatctc catcatgact 2739481 cggctcagcc ggacgtgaat aatcggttgg cagttcaagc tgatcaggca ggtttttcaa 2739541 ggtttctttc cagaaagcaa gctgtccggc aatcaagcta tttggatcat cctcgtttcc 2739601 aagcagttct tgctgccaaa gcgcatagtc tgcatactgc acagcaagag gcgcccattc 2739661 gggagatcgt ccgtggcagc gagccgcata agctgtccca aggtctctgg tcagcggtgt 2739721 taaggaccag ccgtccccga caatatgatg gacgagaaga agcagcacgt actcgtcagg 2739781 accgatcaca aaaagctcgg cacgaaaagc aggttcagct gcaagatcaa agctgtagcg 2739841 tacagcttcg gcaagccgat cagaaagctc cttctcagca atttcagtaa catgtaactc 2739901 gggacaggct cgatcggcat ctaaaatatg ctgataggat gtcccctgtg attcagggaa 2739961 gatcgtccga agactttcat gacggcagac gaggtcataa agtgccgctt tcagcaatcc 2740021 ttgatccaac tcacctgaca aacggacagc aaccggaata ttataagtag gactcggtcc 2740081 ttccagacaa tgcaggaacc atagccggcg ctgggcaaat gagagcggga tcttttcagg 2740141 ccgctcagct ctctgcaaag cgggacatgc actctgcgcc aaatcaagat gggcagcgag 2740201 tccggctact gtcggttcgt caaagagctt ggcgatacca agttcggctc ccattacctc 2740261 gcgaatgcgg ctcatcagac gggctgcaag aagagaatgg cccccaagct cgaagaaact 2740321 gtcatcgata ccgacgcgtg ccaaaccgag aacctctgca aacaagtcac acaatatctc 2740381 ttcctgagga gtccgcgggg cccgatcact gacagatgtg ctgaagtctg gtgccggcag 2740441 tgctttccgg tcaagcttgc cattaggtgt taacggcagc tcgtccatct ccacaaacgc 2740501 cgacggtacc atataatcag gaagactagc ccccatataa cgacgaagct ctgcagtatc 2740561 aatagcagca tcagcgacta cataagccgc caatcgtttg tctcccggct gatcttcccg 2740621 tacgacaacc gcggcctgtt caatgtgcgg gtgattggca agcacggcat caatttctcc 2740681 aagttcaatt cggaatccgc gaattttgat ttgatgatcc gcccgcccga tataatccaa 2740741 agacccatcg gcgcgccagc gggcctggtc tccggtccga tacatccgag ttcccggcgg 2740801 tccgtatgga tctgcaacga agcgctccgc cgttaaatca ggacgatgga aataacctct 2740861 ggccaagccg gttcctgcaa tataaagctc tccgacaacg cccggcggca ccggctgcaa 2740921 tccattatca agcacataca cctgcgtgtt ccaaatcggt ttcccaatcg gaggaacgcc 2740981 cttcagccct tcttcaagaa aagctgcggc agaccaaatc gttgtttcag tgggaccgta 2741041 taagttcgtg actgaacaat gaaggtcttg aagttcctgc aaaagaccgc tcggcagcgc 2741101 ctcgcctcct acaagcactc taagcccccg aagtttctca ggttcactcg ttaccaaagc 2741161 gtgccacagt gtcggtgtcg cctgcataat gttaatatcg aaattttcaa tcatttgagc 2741221 taatgcctgc ggctcacgga tcgtttcttt ctttgcgatc acgatttgcg ctccgctaat 2741281 cagcggaaga tataactcca atgctgaaat atcaaaagcg acagtcgtca cagccaacag 2741341 cctgtcttct tctcctagag aaaatgcctc ctgcatagac agcagaaaat tgcttaagct 2741401 tttctgtgtc acaacgactc ccttcggtct tcctgttgat cctgaggtat agatgatata 2741461 cgcaggatgg tcaagcgaaa ccgatacatc ctgattttcc ggcgaatagc gttttataat 2741521 ctcctgtgta acagcctgat caagcacaag ctcaggtaca gccaggtcat caggcagact 2741581 ggctgctatt tcctcagtcg ttatgatgca tgaaggtttc gcatcctcca gcatgtaaga 2741641 aatgcggtcg gctggaaact ccggatcaag ggggagatac gccgcaccag tcttgagcac 2741701 accaagcatt gaagccacca tctcagggga acgcggcagc gccaaagcga caaattgctc 2741761 cggaccaatc cctttttcga tcaacagacg cgcgaggcgg tttgcctctt cattgagctt 2741821 tcgatagttg acttgaatgt catcacacat gagagcgata cgttctggcg taagaactgc 2741881 ctgcttttcg aacatgtcct gaaggctgac cagcttctcg gattttgccg tctcattcca 2741941 tttagaaatg actttttctt tctcctctgg caacagaagc tccatttgcc caatcagcat 2742001 gtcctctccg gcagaagccg tttgcagcag ctgcaaaata cgctgctgat gaagcttaat 2742061 atcagactca ctgtatacct cgggattcgc atcaacatca attcgcagcc cgctgccgtc 2742121 tgttctgtca tatacattga ttgatagatc atcaacagga ccggctgaaa gattatgcgt 2742181 tgtgccccgg acgccggcaa agtcgagacc gtaatcaaac ggcataagat tgatttgagg 2742241 gccaaataat ctatgatttt ctcctatcaa tttcagatcg cgcctaagct cttcatggcg 2742301 atacttatga tgtcgccgaa tactgcggat ttcccgggaa atttgctgaa tcagttcaga 2742361 aaagctcatc gaagagctta ccgtcagccg gagcgggaga aggttcatca ccatagccgg 2742421 tacattcagt gacgcggacc ctatccgacc catcatgggc aggccgagca caacatcctc 2742481 agagccggtc atacggtgca cataaacagc tgacaccgca atcatgactt catgccagct 2742541 tcctgagaaa tagcgcgccg cttcttttaa cgcgtttaca tcagacggag gcagatatgc 2742601 cgtatgacga agaaaactgt tagatgttct tggcgcccga tcagccaagc tcacaacttc 2742661 aggtgcatct gcaaaacggt ccagccagaa ttgacgatcc ttctcatact gctctgatcc 2742721 gcgataatct gtatcctcct ccaaaatggc ctggagagac ccaaaggaac ggcttttagc 2742781 tgtttgtcct tttataaggg cagtatatgt acttgccaca cgctgggcta tcagggaaaa 2742841 accgaagccg tcgatcgcta tatggtgaat gcgctgatac caaaagaaac gatcaggccc 2742901 ggcaataaac agagcttcat tgaacaaagg ggcataccct aaatcaaccg gctttgctaa 2742961 atcagctttc atccagttta atgctgtttt ttccggatca ggctcagagc tgacgtcaat 2743021 gacgtgcagc tgtacatccg gagacgggtt tatcatctgc caaggcccgt ccatattttc 2743081 accgaagcgg acatgcagcg attccgcttc cttgatcacg tgccgcaaag cttcttcaaa 2743141 aagagcaata ttgactggtc cattgatttc tatatattcc gctgtattgt agattggatt 2743201 gtccggatca agctgctgag caaaccatat gccagtttgc gccccggtca aagaatattg 2743261 aagatctttt gtatcaggca tccgtttgtt taccctcctt ttataaataa tccgcgtttg 2743321 gcagcacttg ctggctgcga gttgtgagca atttctgcca ttcttcgatc gttgggcgtt 2743381 cagccaattc cacgaaagtc acctctgccc cttcacggcg ccattgttcc accaatgtca 2743441 tgatccttac cgaatcaaga ccacgatcga gcaaatcctc ttgatctgtg atgtcttccg 2743501 gtgtttcttg tagaagctca gcaatttgtt tacggatatt ctcacatgta aacacgttct 2743561 ttttgccagt gtttgctgac gttttttgaa cgtctgccgg cgcattctgc agctgatcaa 2743621 gaagactgtc agtcatcacg gtaaacgcac agcgtccagc cgcatattcc agcgccattt 2743681 gatgtttttc taatgaaaaa tcagcaactg catctcccac aaaaaaggct ttaatatcct 2743741 ccataaatgc ttcacatgct gtaacaagac agccgatatg ggcgtaaatt cctgtaatga 2743801 tcagctgatc gcgtccctct ttgcgcatca tttcaagcag attcgttctc ttaaacgcgc 2743861 tgtatctcca ttttgtcagc acaagatcat catcctctgg tgccagctcg gttataattt 2743921 tctcctcata aggaccgctg tttaatcccg ggccccaaaa gtctgtcagc agcgcacggt 2743981 catccggatt ttggcttccc ggctgtgcgg tatagacaac aggaatccca agctgaacac 2744041 attgattctt cagctttcgt atattcgctg aaagctctgt taccggagac gctcccgctg 2744101 tgaaagcatc aacaaaatag ttttgcatat cgtgtattaa caagacagcc cgattcggat 2744161 caggcaccca tgatactttg ttttgcggca tatcagatgc tgtcggcatt tgatacggct 2744221 gaatggcagg tatagccata tgaacacttc ctctcaaatt gttgttttat tttttaaatc 2744281 ctgcaagaag cttctcggaa atggcttcac ggagcgcttt tttgctgact tttcctactc 2744341 ctgtctgcgg gaaggattcg acaaattcaa ctcgatcagg gattttatat gccgccagtc 2744401 cgcgctctct caaaaatgct ttaagctctg cggcttttgg ggcttcatcc cggggaataa 2744461 tgaacacaca agatctttcg ccaagaaatt gatcaggcat ggagaccatt gccgcatcat 2744521 ggacagccgg atgcgccagc agatgatttt ctacctcttc agccgcaacc ttttctcctc 2744581 cacggttaat ttgatccttc gcccggcctt caacgacaat atagccgtct cgtgtcagcc 2744641 tgacgatatc acccgtacgg taaaaaccgt cctcagtaaa tgaagcggcg ttatgctctt 2744701 ctgccttata gtaacctcga attgtatacg gcccccgcgt cagcagatgg cctgtttcac 2744761 caggttttac gtcgcgatca tgatcatccc aaacacgcat ttcatcatat ggagacatcg 2744821 gttttccttg ggtgttgaca atgatctcct caggatcatc caatctcgta taattgacga 2744881 gaccctctgc cattccgaac acctgctgca gcgtgcagcc gaaaacagct tttaccctgc 2744941 gcgcggcttc agcactaaac ttggcaccgc cgacctgcag cacttgaagg ctggataaat 2745001 catcacggcg tgaggatgcc gcatccatcc ataccatcgc aagaggcgga acaagagcgg 2745061 ttatcgtgac cttttcccgt tcaattaaag gaaatgcgtc atctggactt ggagaaggag 2745121 ataataccac tcttcctcca gcgtataata cgccgagaac gccgggtgag ctcagcggat 2745181 aattgtgtgc catcggcagc gcggccaagt acaccgtgct gtggtcgagc cagcagacct 2745241 ccacactccg cttcaggctg tatatgtagt catcgtgggt cctcggaatc agtttcgata 2745301 gcccggtgct cccgccagaa agctggagga acgccacatc cgatgatttg acttcaggca 2745361 gttttacagg ttctgcatgc aaatcctcca gcggtaaaaa ttcctctgcc tcacctgcga 2745421 caatgatgtt tttcaaagtc ggcagcttgc tttgaacctg tctggcaagc gaacggtagt 2745481 caaaaccgga ataagcgtcg ggaatgatat atgcagccgc ttcagcaaac tcgcaaaaat 2745541 atgtaatttc actgcttcga tgagaaggca gtgcgaagac tggaagcgcc cccagacgga 2745601 aaagcgcgaa aatgacttca aaaaactctt tgatatttgg caactgcacc acaacacgat 2745661 ccatctgttg aatgccgagc ttttgaaatc cggcagccag gcgatcagcc cttgtgtcaa 2745721 gctctcgata gctccaatgg gtgtttccgc atgtaatggc aatgcgatca ccatatttgg 2745781 ctgcccggtc ccttaacaaa tctccaaacg tctcaccggc ccagcagccg ttctttcgat 2745841 aggtctcagc taactcatca ggccaaggcg taaatccttt cagcatgttg tatccctcca 2745901 gcaattcatt ctgttcatat gtgatccacg cccattgccc gcagcattgt ccgaaacttt 2745961 gcggacgtct cctgaagctc gtcctcaggc tttgaaccgg ccacaacacc agctccagca 2746021 tacaggcgga gtgagcgttc ttctgcttct gcacaacgga tggtcacgat ccattctccg 2746081 tcaccggcat cgtcacacca tccgaccatg ccggtaaaga aaccgcggtc aaatggttca 2746141 atgctgagaa tcgcttctct tgcaagatca gtcggtgttc cgcagacggc tggcgtcggg 2746201 tggagcgccg ccgccaattc aagtgcggtt acagacgggt cggaaagctc tcccttaatc 2746261 acgctggaca ggtgccacat cgtttccgtt ttgatcagtg aaggcttctc cggaacctcc 2746321 agcgtccggc agaaaggtct cagcgctgcc gcaaccgcgt cagcgacaac cgcgtgctca 2746381 tgaagatcct ttgcggaaga aagcaattca gctgcccggc gctggtcttc aacaggatca 2746441 ttactgcgcg gtcttgagcc ggctaatggg ttggaaacga cctgtgttcc catccttgaa 2746501 acgagaagct ccggacttgc tccgagcaat gttctgcggg gagacgtttc ctcctgactg 2746561 gacacgtctg cggcaaacgt gtagccatgc gagttatgct gagccagatg gcgaagcaat 2746621 tcatccgtct gaatcggttc aggcgatgtc aaatgcagcg atctggacag gacgattttg 2746681 ctgagtgttc catcggcaat gcgtgccagc ccttgttcaa caccattttt ataatcctca 2746741 ggttcaggaa caggctttat gtggtatgta tgcccagcct gctgttcctt ttcctcatga 2746801 tcaaattgaa gcggtcctga ccagcgcact tcttcaggta caacgagccg cgctgctttt 2746861 acttgatcaa aaggaacggc cccgacaaca agcggccggc tttgccctga ttgttttgcc 2746921 tgacgtaacg cctctgcaat tcggccagaa agggtttcca tttggttttg cccgtctgcc 2746981 tccggtacaa tttcacatat gcctttcgct aacagtacac gatgaggaga cgctaagaaa 2747041 aaggcgcccg gctgatattc atgaagcaaa tgctccgctt ttgtttctgt tataacgttt 2747101 tgatccaaca ttctcatgaa cctcctttaa attcagttac acgcctaagg tcgcgccgcc 2747161 atctacgcat aaattatgca tcgtaatatg ccctgcctgg ccagaaacca aaaagagcac 2747221 cgcatccgca atatccgaag gcttggctag ttttttgagc gggatccctg ttttaaatgt 2747281 ctcaagtgat ccttttatga cttgctccgc tccattctcg tcggcccata atgaccactg 2747341 catgtctgtt tccgttgatc cgggagatac aatgttgcag cgaatattgt attctgcaag 2747401 ctcaaggcca aggcatttcg taaacatcac agccgcagcc tttgaagacg catatgccgc 2747461 catagatgtt cttggtacac cggcagcatt cgatccgact gttacaatcg aacccgatct 2747521 tcggtccatc atatatttgc tgactgaacg cgaggcgtta aatacgccag tcgaattcac 2747581 tgagaacgtc gcctcccatt cctcatcgct aagcgaatgg atcagtcccg ggcgaaggac 2747641 acccgctaca ttcactaaaa tatcaatcgg ccccatttca cgttcgatgc gcgccgtgat 2747701 ctcgtcaatc gccgcgctgt ctctcacatc cgcaggaaaa gcttctgcat ggcggccttc 2747761 tgctttgagg ctgctcacaa ccttttccag cttttcagga ttataatcaa ctgccgcaat 2747821 atgtgcgcct tgactggcaa gcgtccgcgc aacagcttcg cctattcctt gggcagcccc 2747881 tgttataaaa gcaatttttc cctctatacc ctttgcattc atatcatcaa ttcctttctt 2747941 cgctctaaat gccaaacaga catccagcga aaaagactgc tgcgccttga aaaacgcaat 2748001 ctattgataa tgattatcat tatcaattat aaaaataatc atatccaaat gtcatgtgac 2748061 agtcaaatat aatttcagtg acaaatattt ttttaaaggc aaggctgagt atgtctcagc 2748121 ccattgatag atgcggtccg tcagggtgaa gcgcaaaacg cagcgccctg ctgaccaaaa 2748181 caggaagaac tgaaatatgt ccttctcctg aaaactcgca aaattctgcc cgtatacctt 2748241 gttcagataa aacggccagc cgctcataaa gctcccttgc attatcattc atccggcttt 2748301 tatgatgctg ctctaattct cctgcggcaa gcaggatatt gataggctga ttgtttttct 2748361 tggtgagaga gacgaaatgg tccgttttct tgagaataaa cggtttattc caatgaatgg 2748421 acggacttcc cgcgatatac gtttgaaacg catcgggctt tgttagcagc acctgcagca 2748481 cgaaaagccc tccgagcgaa tggccaaaga ttgtttgtct ttttttatca atctggtaat 2748541 ctcgttctat ctccggtttt aaatcctctt caataaatct gaaaaagccc tccgctccgc 2748601 catgctccgg ccattctctg ccgtcgggcc tttccggcag cttcgattgg gctgttggca 2748661 ttgtaaaatc ccggtggcgt gctgaggaga acggctccgc tgtctcatag ccaatgccga 2748721 cgatcactgc agggatcacc ccggtttttt cgggtcggcg tccctgtatt cgaacggctt 2748781 ccgtcatcgt tccgaagaca gaattggcat ccagcagata aatcacagga taaccagcgg 2748841 gtggcggcgg cgtactaggt ttcgagataa aaatgtgata ggtacggttt tcattgcgtg 2748901 aagacatcat acgcacttcc gtaccaggaa tcgtaaatgc gtttgatgtc ccgccatttg 2748961 tccggtctgt tgtttgttct ttcatgcagt acgacattcc tctccttaaa ctaaaccgca 2749021 atgtatgata atgattttca ctatcaacta gacacctcaa ataataggtt ttcttccaaa 2749081 gaaagtcaac tttttcccga ataaaaaagg caccttgatc aaataaggta cctgcagact 2749141 atcaatatgg aagtaaaaac ctaataaaga tgcgtattgt cctatttgaa atagaacctt 2749201 aatcccatgt aaacctttga ttttgccaag ggtcgcctct catgtgatag ccattccgct 2749261 cccaaaagcc agggtgattt tctttcgtaa attggatgcc gcgcagccac ttggcgcttt 2749321 tccaaaaata cagatgcgga aatacacccc gcagcggaaa gccgtgttca ggggttaaag 2749381 gttcgccatt atgcgcataa gccagaaggg aagtttccgc taagaaatca tcaagcggca 2749441 gattggtcgt ccagccctct tcagcatgta aaatgacgta gcccgcttct tcttttacac 2749501 ccgctttttc cgctatatca caagcccgca cgccttgcca cacattatca agccttgacc 2749561 atcccgtgac gcaatgaatg tcgtttttcg attcataccg tggaaaggct ttgacatctt 2749621 caaagcttag cagcatcgga tggtcaacca aaccgtatac ttgaagattc catttcgtca 2749681 tatcttcgta atatgggaca tctccggtat gaagcacagg aaatgaagtg gtgacgtttt 2749741 gatttggcgg cactcttcca gattgatcgg actgtcttgt ttttccgaaa tacatatggg 2749801 cctccttttt gttaacctaa tttaaaatca tgttgacaat ctttttgttc tttattactc 2749861 tatgattgtg tatgtcaacc taagggggaa caacgatgaa acaacgtaaa cttcgtgcgg 2749921 gagatatggc gctgattggc atgttcgccg cacttatggc tgtcggggcc aacattacat 2749981 cagtagcacc ctttttacaa gtagccggca ttccgctttc gatgcagccg tttttctgtc 2750041 tcttggcagc tttgcttctt ggcagcaaac gggcagcgat tgccatgatt gtatatgcac 2750101 ttgtgggatt ggccggagcg cctgtgtttg ctcaattttc agcaggcttc gcaccgtttg 2750161 cagggaaaag cggcgggttt attatctcat acattccggc agcatttgca gcgggatggt 2750221 ttttagaacg aaacattcag ccaagtaaaa ttcgatttct cattgcttca cttatcggaa 2750281 cggcgatcat gtatctcatc ggcactacct atatgtatct tgcactgaag ctgtggattc 2750341 atacgccagt gagctacggc acggcttggg gctttatgat ttggtttatg gtaaaagata 2750401 cagcgctggc tgtgatactg tcgtttatcg caccagcaat ctaccgctct attcataaag 2750461 caaccggctt taacagaaat cacatatcat ctacgtaaaa accgttctat tggacggttt 2750521 ttttatcata acgagaaaag gctccccagt aaaggggagc ctttttccta taaaacaagc 2750581 gctgcaatcc agccaaagat gacaagcgga atattataaa atataaatgt cggcacacaa 2750641 gtatcccaaa tgtggtgatg ctggccgtcc gcactcaaac ctgaagtcgg cccaagcgta 2750701 ctgtcactgg caggtgaacc ggcatcgcca agcgcagcag cagccccgat aatcgcaatc 2750761 gttgccatcg ggctgaatcc aagctgcatg catagaggca cgaaaatggt tgtgataaca 2750821 ggaatggtcg caaaagaaga tccgatcccc attgtaatta ataagccgac aatgagcatc 2750881 agcaatgcgc ccaaggactg actgtgtccg ataaaaccag ctgacgtttt gaccagtgac 2750941 tcgacatctc cggttttcgt caatacgttt gaaaatccgg ctgcaacaag catgacaaag 2751001 ccgataaagg ccattaaaac cattccatca gtaatcagtg agtccgcttc atcacgcttc 2751061 atcacaccgc tgacaaacag aacaatcaga ccagcgagcg cccccataat cattccttct 2751121 actcccaaag tctgagataa gtaaagctgg acgccgagtg acacaacaat ggctagaacc 2751181 gcgataccaa tactttttct cgtatatggc gatgcttctg cacctgaaat gtcttttgtt 2751241 tcatattgtt tcggtttacg gtatacgatc actgataaaa taaggccgac aaccatacct 2751301 gcaactggaa taatcagtgc gtacggaata tcagcaagcg gaacgtttaa cccggcatcc 2751361 gccatattgt ccttcagcat gccttggaag atttggccga aaccgaccgg aagcaaaata 2751421 taaggagccg ttaagccaaa tgtaattaca cacgcgatca gacggcggtc catttcaagt 2751481 tcattaaaga ttttcaaaag cggcggaatc agcaccggga taaacgcgat gtgaaccgga 2751541 acgacgtttt gcgaaaaaca agatacaatt aaaataatca gcacaatcag caccttagac 2751601 agtgcttttt ttcgagaatc ttctttattt ccgattaatt taacggaggc ttccaccatt 2751661 gcgtccggaa gacccgtttt cgtcaaagcg gcggcaaacg cgccaagcat ggcatagcta 2751721 actgcaacgg tggcatttcc gccgagaccg tctgtgaaag ctttaaccgt ttcgccaaga 2751781 ccgagcccgc ctgttaaccc gccggccaag gcgcctataa ttaatgcgat aacaatattg 2751841 acacgcagca ggcttaatac aagcataagc aggactgcga tgacgactgc attcatgatg 2751901 atacccctcc aaaaatcctt tagtttgcta atgtagtaga taaataaagt acgaacgtat 2751961 cgtatcataa ccgatccact ttagtcaact aaagatttcg gaagaaaaaa tccctgccgc 2752021 atcatacagc agggattttt cattactcgt ttttatcttc ttccaatgta aatcgctccg 2752081 caagtgtagc cagtgttctt gccataacgc cagtagcccc ggccggtccg aagcaggttg 2752141 ctttattggc agtcgctgtg cctgcaatat caaggtgaac ccaaggtgtt gactcagcga 2752201 attcaccaag aaacgttcct gccataatcg catgtccctc gcgtcccggt gaattgctga 2752261 gatccgccat ttggctgctt ttcacgcgtt ttttatcctt ctctgttatc ggcagctgcc 2752321 agatcgcctc gccgcactct tgtgcagcat cagctacctg ctggtaaaag ctttgatcat 2752381 ttgtcattgc accggttgtt tctgttccta atgccacaac gacgccgccg gtaagcgtag 2752441 ctacatcgac aagaactgat gcgccatgct gtttcgcgta tgtaatgcca tctgcaagca 2752501 ctagccttcc ttcagcatcc gtattaagga tttctattgt ttttccgctt aaagatacga 2752561 tcacgtcatc cggcttcatg gccccgccgg agatcatatt atcggttgat ggaataacgc 2752621 acagcacgtt ttgttcagga cgaagctctc cgatcgtttc catagccccg agaaccgcag 2752681 ctgctcctcc catatctgat ttcatgccaa caattccaga tttcgtttta atggagtagc 2752741 cgcctgtgtc aaaggtaatt cctttcccga ctagtccgac gacgtcttcc cattcctttt 2752801 tgccctgata tttcaacaca atcattttcg gcggttcggt ggagccttgg tttaccgcaa 2752861 gtattccgcc cataccgagc tcttccatct ctgatttctc caatatctca cactcaaaat 2752921 catatttcgc cgcaagctct tcagcatacg aagcgaggtc agtcgctgtc agcatgtttc 2752981 ccggcatatt cacaagcgtt ctagccgaat ttgtcccttg tccgtatgcc tggccgacgc 2753041 gaagccctgc ctgcacttcc tgtgtatctt catctgttac aacatacacg gcttcaattt 2753101 gtttgtcagg ctcatttgat ttatgcttat aatcctgcac ctcataggaa gcaagcaggc 2753161 agctctcagc taaagcatga gcggcatcgg ctggaggcac gtcttccgaa ataaacgtat 2753221 caagcagaac agcagtttct tgttttcgat ctttatgaat ggcttgaaaa acatgagcaa 2753281 aacgttcctt cgcctgttca aacgaataat ttgcttctct ccccaggcca acgaaataaa 2753341 tccgtttcat acccgcagaa gatggaggga atacttttga tacttgattc ggtttcgcag 2753401 agacatcacc ctcttttaaa agctgtgtca gatggccttc gagcatttca tcaatttcca 2753461 acgcttttcc tgtcagctgg cttttttgaa aaagcccgac aacaagggtt tctgtatgct 2753521 ctgattgttg aaccgcataa aacatgaggc ttacactcct aacgtaatgg gtatttgtaa 2753581 tgaacaatgg tataatagga aaaacattct ttccactata cttattttaa caaacaacag 2753641 tctaagactt gcttttttct tttgaaacac gaaggatttt tcaaatagaa aggatgtcgc 2753701 cgatggaact tttaacgaat tttcctttat tatcaagcct ggccgcaatt atttttgctc 2753761 aggtcatcaa agtgcccata cagtttatcg tgtccagaaa actggactgg tcgctggtca 2753821 caagcacagg cggcatgcct agctctcact ccgcagcggt cactgcgctt tctacaggcg 2753881 tagccttgga gcatggatta gactcctcac tctttgcggt ttccgccatt ttcgccgtca 2753941 taaccatgtt tgacgcaact ggcgtcagac gtcacgccgg tgagcaggca acagtcatta 2754001 ataagcttgt tattgatttt aaccgtttcg taaatgaagc gaaggacttc cctaaggctg 2754061 cagagaaaga aaagcaaaaa aagctgaaag agcttctcgg acatcagccg atcgaagtct 2754121 ttttcggagg attaacaggt attttactga cattggtact cgcttacttt ttcatgtaaa 2754181 aaaaacgctc ctgctttcgc tggagcgttt tattctttca ccgttttata ttgatttctg 2754241 aacacttgca aagattttgt ttcattgagc ttctcaagct catcctcggt aatctttccc 2754301 gttccctttt taatcacata tacatcaagg gtttttttgc cccattcatt gtatacatct 2754361 ttgactgtct caaagtacag atcaaggcgg tttcccttaa tagctgatcc tgtgtcggcc 2754421 acaactccga gaccgtagtt cggaatgaat aaaattgttc cgatcgggaa aacggacggg 2754481 tcagcagcaa ccgtggaata taaatcccgt ttcactttca cacctgaata tgtaagcccg 2754541 tataatggat caccgggatt tttgcccgtc gactcagctc ctgctgtgta gcctgttgct 2754601 gttactcttt ggactggata ttcatcccaa tcaaatgcct cttctaacgg ttttgtttta 2754661 tcctcagccg cggacgtggt ttgtgtttgt ttctgctgca atgcttttaa tctcagtcct 2754721 gcatgcttca agtgcttttc ctgatgttcc tgcacccatt ttgacaagtc cttcgcttca 2754781 attcctgaca ctgataaaaa tgtcgtgcca aatgcaagca gaaataaaca ggtcatcagc 2754841 aaacgtctga tcatattcaa catcattcac ctctcctccg aatcattgtt cccaagtgga 2754901 gagagcatta ttcaaaatgg tgaatgagct gaacgcataa aaaaagcttt ctttagaaga 2754961 aagcggcatt taaaacattt gatatcctct ttttctaagc atgttgatcg ctataccgga 2755021 cacgatggcg ccggccaaac cgctgactaa aatcagcaca tcagcagccg ctaatgataa 2755081 gacacgatga aacaggctgg caaaggattc tcccggcgac tggacatagc tgatcagctt 2755141 ttctttgctg ataatgaaaa ggcatacaat tggataaatc acagccataa tccaagacat 2755201 tctcagcagc atgtttaata agaaaccgat tccaaaaaac aagacaaaaa acaaaacaat 2755261 tgagatgatt acgactggca gactaatcaa cctattccac ccccctgcgt tgtttttagt 2755321 gtaacgcggg ggctgaaata aagtcaacgg ctggaaaaag aatgactgtc ttttcctgtc 2755381 ccctggcaag acggacaagt ctctgaaccg ccgagaatca attgaaaata tcctttccct 2755441 gaacaaaatg ggcatgcatg tgaagcggtt gtcgttgcag ttttcatcta atcatcaccc 2755501 tttttcttaa ttttctgata atataccata tcaagctgtc aacaataaag tcagatcatg 2755561 tgacaaatct tttgatgtaa gcggaaacat acttgttttc ctctcgttct ctttttattt 2755621 tggcgttttt taataaagaa aacccgcttc cgcgggtttt tagaaaaact tgaacttgcc 2755681 ttttttcaat gtcagtccga gtccgccaat cataaacagt gagcggttat caatgacttt 2755741 tttcataaac gaagcgggcg tgcctttcag ctttctgcca taaacaaccc caaccgcgtt 2755801 atgctcgcca agagaagcca ctgttccctt aatgtccggc ttgaattcct caagctctcc 2755861 gcctttaata agcctgccaa ggtttttagc gaccgttatg ccctgctgca ttgcaatttg 2755921 cgcagtcggc ggatacgggc gctctgtatc ttcattcata aacagcgagc tgtcgccgag 2755981 aataaagaca ttgtcatgtc ccggggcgcg gagatcaggg ttgactttga ctcggccgcg 2756041 catattctca aaaccggctt cctccacaat cggatggccg cggacacctg ccgcccatac 2756101 aacggtttgc gatttgatct gctctggttc ttcatctttt ttgccgactc tgactccttc 2756161 tggtgtacat tcttgtacag ccgttccgat cttgaactca actccgtttt cctcaagata 2756221 atgtacggcg taatcaacaa gttccggatc aaagcccggc aaaacggtcg gcgctgcttc 2756281 cacacaaatg atgcggacaa ggcttctgtc aacgtcatat tccttacaga gctccggcac 2756341 gcgagcagcc agttcgccaa gaaattcaat tcccgtaaat ccggcaccgc caacaacgat 2756401 cgttaacctg tccggccgtt tttccgcttc cgtattgtaa gtcgcaaact gcagctcaat 2756461 atgttcccgc agcaggcgcg acgtgttgat gttggcaatc ggaaacgcat attcttttaa 2756521 gcctttaatg ccgaacgttt caggcacggc gccgagcccg atgactaaat aatcgtactg 2756581 caattctcca ttcgcaagca caactttttt ctcatcaatt ttgattgcct ttacggtatc 2756641 ctgtacaaaa ttcacccgtg actggttgat tacatctttt atctgataac ggcagcggtc 2756701 atgatggagc gtacccgcgc tcgcttcatg catccatgtc gtttcataat gataattgtg 2756761 tttatttaca agcgtaatgt cagcatcatt cggcccgaca tacttcgtca gccttgtcac 2756821 cgtcatcaat ccgccatatc ctgcacctaa aatcacgatt ttgggcttat tcaatgccat 2756881 cacatccacc ttctcttttt ttgcttttgt tagacccata ataaaatcat catttgtgtt 2756941 agcttcagct tattggcggg attttatgaa atatattgaa aagttttttg tgaagtcctt 2757001 acccgtagca ctattatcat gtttatccgg ctggcccaag aaacattcag aaaaagatca 2757061 tttcatttgg ttattatcgt agcggcctgc ggaaatattt tcaagaacgg atgggcacgt 2757121 tagatcctta cgattttttc tgctgactcg tcaatttgaa cggcaatatg gtataattaa 2757181 taacaatttt catttaggag gcaattttcg tatgcgagag gatacaaagg tttatgatat 2757241 tacaattata ggcgggggac cggtcggctt attcaccgct ttttacggcg ggatgagaca 2757301 ggcaagcgtc aaaattatcg aaagcctgcc tcagctcggc ggacagctta gcgccctata 2757361 ccctgagaag tatatatatg atgtagcggg attcccgaaa atccgcgcgc aagagcttat 2757421 caataaccta aaagagcaaa tggcgaaatt cgaccaaacc atttgtctgg agcaagcggt 2757481 tgaatctgtt gagaaacaag cggacggcgt gtttaagctt gtaacaaatg aagaaaccca 2757541 ctactctaaa acggtcatca taactgcagg aaacggcgca ttcaaaccga gaaagctgga 2757601 acttgaaaat gccgagcagt atgaaggcaa aaacctccat tacttcgttg atgatctgca 2757661 aaaattcgcc ggcagacgcg ttgcgatcct tggcggtgga gattccgcgg ttgactgggc 2757721 gcttatgctt gagccaatcg caaaagaagt atcgatcatt caccgccgcg acaagttccg 2757781 agcgcacgag cacagtgtgg aaaaccttca tgcgtcgaag gttaatgtcc tgacaccatt 2757841 cgtccctgcg gagctgatcg gcgaagacaa aatcgaacag ctagtgcttg aagaagtgaa 2757901 aggcgaccgc aaagagattt tagaaattga tgacttaatc gtcaactacg gtttcgtttc 2757961 atctcttgga ccgatcaaaa actggggcct ggacatcgag aaaaattcca ttgtcgtgaa 2758021 atcaacaatg gaaacaaata tcgaaggctt ctttgcagca ggtgacattt gtacatacga 2758081 aggaaaagtc aacctgattg ccagcggctt cggcgaggca ccgacagcag tgaacaacgc 2758141 caaggcttac atggacccga aagcccgcgt acagcctctt cactcaacaa gtctttttga 2758201 aaataaataa taaaaaaagg agcttgtgtc tgcgacacag ctcctttttt atttgaagat 2758261 atttatataa ttcaatgcag ttcctacaac cagcgcaatc acaagggctg cgactaccca 2758321 gatcattgcc ataataatgc ggtcctgaat cttttgggac ttcggtgttt tttcttcgtt 2758381 ttgggccatc ttattcgctc ctttcccatg tccatgccat aaagaaagcc tggtgctgaa 2758441 cgaccaagct ttgctgaacg tatatcattc gcgttttgat ccgctctcta agaccattcg 2758501 ttaaaactat gatacctaaa ctcaccctgc atgacaagct tcggcacttg caccacacct 2758561 gccagcaaat cataatgttt gacatcctaa ataaaacaga gtacattata taaggcgaac 2758621 atttcatata ttatactttt aaatattcgt ttttaggagt gaaaaccatg gaaaacgtat 2758681 ttgattacga agatattcag ctaattcctg caaaatgcat tgtgaatagc cgttcagaat 2758741 gtgatacatc cgtacgttta ggcggacata catttaaatt gcccgtcgtc cctgccaata 2758801 tgcagacgat tatagatgaa aaactagcga tttcattagc cgaaaatggc tacttttatg 2758861 tgatgcaccg atttgagcct gagacacgaa ttgattttat taaagatatg aacgcacgcg 2758921 ggttattctc ttctatcagc gtgggcgtca aagatgagga gtatgaattt gtccgccagc 2758981 tggcagaaga aaatctgact cctgaatacg tgacaattga cattgctcac gggcactcaa 2759041 atgctgtcat tgaaatgatc cagcacctta aaaaacattt gccggacagc tttgttattg 2759101 ctggcaatgt cggaacgccg gaagcggtca gagagcttga aaatgcggga gcggatgcca 2759161 ctaaagtcgg catcggaccg ggaaaagtat gtattacgaa aatcaaaaca ggcttcggca 2759221 caggcggctg gcaattagca gcgctgcgct ggtgtgccaa ggctgccagc aaaccgatta 2759281 tcgcggatgg cggcatccgc acccatggcg acatcgcaaa atcaatccga ttcggcgcaa 2759341 cgatggtcat gatcggttca ctatttgccg gacacgaaga atcgccaggc caaacgatcg 2759401 aaaaagacgg aaagctttac aaggagtact tcggctcagc ctctgaattc caaaaaggcg 2759461 aaaagaaaaa tgtcgaaggc aaaaaaatgc acgtggcgca taaaggctca atcaaggata 2759521 cactgattga aatggagcag gatcttcaat cttctatttc ttatgcaggc ggaacaaagc 2759581 ttaacgccat ccgcaatgtg gattatgtga ttgtgaagaa ttccattttt aatggggata 2759641 aatattaatc ataaaaaaac gccaagtcag cggttctccg cttgagttgg cgttttctgc 2759701 tacttcttca gcaaagtaag cttatatttg ctttttgagt ttatcttcca tcagttctgc 2759761 catttgtttt gcatttggat tttcttcatt ttgcaactgt tcaatgacgt tcatataatc 2759821 cgtttcattt cggttctggc ttaatttata tgccgcttga atgtcttcca ccttaatctt 2759881 aaatccaaca atacctttca attcactttc taagagtttt ggagaaagct tatcccataa 2759941 cacaggattg tcacgatgtt tttcgtattt ctccaacatg attgttaatt cttctgctaa 2760001 ttcatctttc tctaacatac ttgcttttcc atacatgtgg acagcctgat aattccacgt 2760061 cggaacattt tcgcgcgaat accaggaaga agaaatataa gcgtgcggtc cctgaaacat 2760121 cacaagcaca tcttcacagg cttcaaacgt tctccactga ggatttccat aagcgaaatg 2760181 ccccgtaata tagtaatgat cgtctttttt attgaatcct aacggcaaat gtgtggcaat 2760241 tggttttcct tgttctgttg tgacaaccgt accaaaggag ttttcttgta caaaattcca 2760301 aatttcttca gcatttgtga ctttaaaata ttttggaata tacatcatca tccacccttc 2760361 gaaaaatatt atatgagtgt tttagccatg attaaatccg tttgttcttc atcacccata 2760421 taaaatgagt gggcgccggt ctgaacaaac cccattttct tataaaaggc aatggcattt 2760481 tcattttttt cccacacacc tagccaaatg ttctttttat tacgttccag cgcaatttct 2760541 atcgctttat tcagcagatg tttgccaagc ccatgttttt gaaagctgtt ctttatataa 2760601 attctctcga tttcaagtga ttcagcaccc atttcttcag actgagcatc atcgatattg 2760661 acctttacat atccagcgat ttcatgatca aagtaaataa aaaagaattg cgaagacata 2760721 ttagataact ctttttccag ctgctcagtg ttaaatgcgc tttctaaata ggctttcata 2760781 ttttcaggtg agttctgttc tttaaaagtg tcattgaatg tttcaatact caattgttga 2760841 agtgtttgta aatcttcccg gctgcatttt ttcattttta cactcattgt tcggattcag 2760901 cccctttatt taaaattcaa ttgtcttgtg tcccttttat atatttaaac acggaacaca 2760961 tactgacctt gttaccattc caaaaatctt cttcatcacc aactccctat cgtgattttg 2761021 ttgtaaatgc aataaaatat actccgcatt aaatatatcg taactttgct gtatttacaa 2761081 caaaaatcaa acaacaaagc agcgtttctc ttgccgaagt tcccggaact ctctgcatca 2761141 tttccccata ataaaaacgc ctcccttaac gatgatttat cgctaagaaa agcgtcagta 2761201 atagttgcta tccgttttta gtgcttagca ctcttcaggc ttgcctgcat tcgttgctgt 2761261 tctgaacgaa gaaccgcagc cgcatgaagc gatggcgttt ggattgtcga tggtgaagcc 2761321 gccgccgagc atggattgtt tataatcaat cacggtgccg ttcatgatgt caaggctttc 2761381 tttgtcaact agaacagtga tgccgtgctg atcaaacaca ctgtctgatt cactcttttc 2761441 atgctcaaag cccatgccgt aagaaagtcc gctgcagccg ccgcctttga cgcctacacg 2761501 cagaaacgcg ttttcttctt catgctcttt catcatatct tttatatgca aagctgctgc 2761561 ttctgtaatt gttaccgggt tgctcatcat tatgaacctc cttttaaaaa ccggttgctg 2761621 tcttttatta taaacatgat cgttccaatt ctcaaacaag gtgttttaca agaaatagac 2761681 accctcacaa acggtttcag ccggccctgt catcattaca tggccgttat ctttccagtt 2761741 tatcaccaaa tccccgcctg ctaaatgcac cgtgatgtct tgatttcgct ttgatacgcc 2761801 gtttaataca gatgcgactg ccgctgcaca tgctcctgtc ccgcatgcct gagtaatccc 2761861 tgatccccgt tcccagacgc ggaaatgcaa ttcttgttca ttcacggttt caacgaattc 2761921 cacattgatg ccttccggaa atctcggatc tttctcaatc accggcccca gtgtcgttaa 2761981 gggtgcctgt tcaatgtctg cgatcggaaa aacgatatgc ggatttccca ttgaaacggc 2762041 agtgcctgtt agttctactt caccaaatgc catcgtttca ttgattgtgt gctcttcccc 2762101 gccgtcaagc ataggaagct cggattttgt caagcgcggt tcgcccatat cgacagtgac 2762161 cacattcact tttccgtttt cgacttgaac ctccgctttc acaagcccgg agagagtttc 2762221 aatcagaaaa gatgtttcct caaccagctt atgctcatat gcgtattttg cgacgcagcg 2762281 caggccgttg ccgcagtttt tcccttcaga cccgtcatta ttaaaaatcc gcattttaac 2762341 aggcgcttgg tctgatgggc atatcaggat cattccgtcg gatccgatcc ctgtataaac 2762401 agaagaaacc tgaattgcaa tctctgacag tttttcttct ggaagctgtt cttcaaattg 2762461 attcacataa atataactgt ttcccaggcc gtgcattttg gtaaatcgaa atgagttcat 2762521 aggtgcctcc aacttttttt ctttttctta gtataaaagc tattataagc ggacacaata 2762581 caattatccc ccgtttttca tacataaaag ctccttgcac tgacgcaagg agcttttatc 2762641 gtttatataa acatgccggc aatggctgcg ctgagcagat tggctaatgt tcctgcaaga 2762701 acagccttca ggccgagacg tgcgatatct gaacggcggc tgggcgctaa accgccaagc 2762761 gtaccaagca taatcgcaat tgatgaaaaa ttggcgaatc cgcataacgc gaaactgata 2762821 atggtagcag ttttcttaga aaactcgccg atgtgcgaac cgaagttaga ataagcgaca 2762881 aactcattca gcaccaattt ctggccgata tagcttcccg cctgcaatgc ttcatgccaa 2762941 ggcacgccaa tcaaaaaggc gataggagaa aacacatagc cgagaatgga ttctaatgtt 2763001 acgcctttta aaccgaacaa gccgaaagcc ccgccgagaa taccgtttac tacagcgatt 2763061 aacgcaacaa acgcaagcag catcgcccca acatttaacg caatttgcag tcctgttgac 2763121 gctccctttg cagctgcgtc aatgacattg gctgcgcctt cgccttcatc cattttgaaa 2763181 tcgcttttta cggtttgcgt tttttccgtt tcgggtataa tcaatttacc aaagactagt 2763241 ccagctggag cagccataaa gctggccgcc agcaagtact caatcggaat accgagaagc 2763301 gcgtacccaa acaaggtaga tcccgcaact gccgatagac cgctcgtcat aatcgtaaac 2763361 aactcagagc gcgtcagccc ggcaatcagg ggtttgatca ctaacggaga ttctgattgt 2763421 cctacaaaaa tattggcagc agccgccaga gattccgttt tgcttgttcc aaggagcttc 2763481 gacaatccgc cgccaatgac acggaaaacg agctgcatga ttttcaaatg atataaaact 2763541 gcaatcagtg ctgagaagaa aatgataacg ggcagtacac ttaatgcaaa tgccggactg 2763601 tctccgacct ttagaagcgg tccaaaaata aaactgatgc cttcattcgc atagtcaatc 2763661 agaagctgta cacggcttga aaaccataaa aaaacagcgc gtcccgcttc ccatttcaac 2763721 acgatgtatc caaacgccac ctgtgtgcat aaaccaacga tgacggttct tatcttaata 2763781 ttgcttttct tttctgaaaa taaaaacgcg atagcaatga tcgcaactgc gcccagcagc 2763841 ccccacagaa cattcatgaa tactcgtaca cctcttaaat tttatttaaa aaaatatctt 2763901 ttatacgata acaataatat tttttgatgt ctacacattt ttttagttct tttgtacggc 2763961 aaaataaaaa agggcctgtc caggcccttt tctttaaaac attggatttt cttcaataaa 2764021 ggtatatata ttctcaacaa gctcagcagg cgtttcaccc atgacgactt ctccgtttac 2764081 cagagcgaaa agcgattcca tacatgtccc gcagtagctt aagcagccat attcaaggac 2764141 atcaaggttg ggatccttct ccaaaatcgc ccgggcttcc tgagagccgt gagccagatt 2764201 gctgacacaa aattcaatca ttggattcat gcggtttcac ctcacatatg tccattatcg 2764261 cgaatttttc actattcgtc aaagacaacg gatgattcaa aatttattat cgtaacatat 2764321 tatttctcaa ataacgtttt actaatttgt gttttcaggc taaattgtag gttattttga 2764381 aactattatt gtgattttag atcaaattcg atataattct agatgttatt ttacatagtt 2764441 cgtattttct tcaatgtatc tatcatactc ttcggattaa aggggaattc aaatgaaaaa 2764501 attggtcttg atcggcggag gttacgggaa catgcgcgtt cttcatcgct tattgccaaa 2764561 ccagctgcct gatgatgttt caatcacgtt aattgacaga aatccttatc actgcttgaa 2764621 aacagaatat tatgcccttg ccgcaggcac aatttctgac catcatatca gagtgtcatt 2764681 cccagagcac cctcgcctgg atgtccaata cggtgatatc acatcaattg atattgtaca 2764741 aaaacaagtg ctgttccaag atcgtgaacc gatttcttac gatgacgcca taatcgggct 2764801 cggctgtgag gataaatatc acaacgtgcc gggagcgcct gaattcacct acagtattca 2764861 aaccatcgat cagtcccgcg aaacctacca aaagctgaat aatctgagcg ctaatgccac 2764921 cgtcgccatt gtcggagcgg gcttaagcgg cgttgagctt gcaagtgaat tgagagaaag 2764981 ccgtgatgac ctgaacatta ttttgttcga ccgcggtaat ctcattttat caagctttcc 2765041 cgagcgttta agcaaatatg tgcaaaaatg gttcgaagag cacggtgtcc gcattattaa 2765101 cagggcaaat atcacaaaag tagaagaagg cgttgtgtat aaccacgatg atccgatttc 2765161 tgcagacgcc atcgtgtgga cagccggcat ccagccaaac aaagtcgtca gagacttaga 2765221 tgtggagaag gacgcacaag ggcgtattgt attaacgcct catcataatc ttccaggtga 2765281 tgaacatctg tacgttgtcg gcgattgcgc cagtcttcct catgcaccga gcgcccagct 2765341 ggcagaggct caagcagagc agattgtcca aatcttgcaa aaacgctgga atggagaagc 2765401 cctgcctgaa tcaatgccgc agtttaagct gaaaggcgtc ctcggttcac tcggaaaaaa 2765461 agccggcttc gggcttgttg ctgaccgtcc gctgatcggc cgtgttccgc gtatgctgaa 2765521 atccggcttg ctgtggatgt ataaacacca taacggttaa tgatagagaa gaaccgctga 2765581 tcaagtcagc ggttttctgt atacccatgc ttctccattt cctcataaac gtcttttaat 2765641 tttggattgc cttcaccgac aattttgtct tctacaagca caagcggata aaaatactcg 2765701 tcatttctga ttttttccgc aagctctttc gcatgttcat tgtcaggcgg ctcatgaata 2765761 tcgatgtact gcatctcaaa aggctgattt ggatattttc ttttcagcgc agcctcaagc 2765821 cactcgtatg tatccttggc tgtcggcata tttacacagc tcgcacaaac gttttctgcc 2765881 ccgtacacgc ttagcatgac tggtttcatc acttgtagac gcccccttct cctatgtaag 2765941 tcctttcttt taagtataca gagcctaagg gcgtttttat agaaaaaaac cgtttttgtg 2766001 ttgaagtctg aatgtgctat aatagggaaa gcaactttgc aaaccaaaca atagattttt 2766061 attgttacac tgaatataat ggttttatga cgacgaaagg agcgaatgtc atgactgaag 2766121 ttgaaatgaa agaacaggtg caggaagtac tggacaaact tcgtccgttt ttacttcgtg 2766181 acggcggtga ctgtgagctt gtagacgtag atgaaggtat cgttaagctt cgtcttctag 2766241 gcgcatgcgg cagctgccca agttcaacaa ttacgttgaa agccggaatt gagcgcgctc 2766301 ttcttgaaga agtgccgggt gtcgttgaag tagaacaagt cttttaataa agcagccagg 2766361 ctgatatttg atcagcctgg cttttttatt agagatgttg atcaaaccat gagctgatat 2766421 aattcaggcg cttgatccgc tgtcttgggt gtccggtgcg tgataaattg tgcgatgcat 2766481 tcggaaaacg gacaagcttg gtttccttgc ccattttttt cagagcgata aacagctgct 2766541 ccgcctgctc gatcgggcat cggtcatccc gctcgccatg cagtatcaaa agcggtgtct 2766601 ccacgtttgc tgcgtatttt aaaggagacc ggtcccagag cttttctgtg tcctcaaaca 2766661 tgtcatgctc aagctgccag tctgtaaaga aatagccgat atcactgacg ccgtgaaagc 2766721 tgatccaatt tgatatcgag cgctgggtaa cggcagcttt aaagcggttc gtctgcccga 2766781 cgatccagtt ggtcataaaa cctccgtagc ttccgcccgt gacaccgagc cgcttaggat 2766841 caatatgcgg atctcgtttg atagcctcat ccacagcctg catcacatcg tcataatcct 2766901 ttcccccata atctcctctg accgcattca caaattcctg cccgtagccg tggcttcctc 2766961 tcggattgat ataaacgacc gcgtatcctt tcgccgccag cacctgaaac tcatgaaaat 2767021 atgtatgtcc gtacatcata tgcggaccgc cgtgtatgtt aagaataagt ggatatgttg 2767081 tctcaccttc catttgtgca ggcctcatca gccagccgtt caccatcacg ccgtcttctg 2767141 tagcatattg aatctcttca ggtattgata tcgtatgctc cctgacaaac ttgtcattcg 2767201 cgccagtcag ctgtttctct tcctgtccaa gcgggatact gtaaagctca ctcggtctgt 2767261 ccggctttgt cacactggca ataaagtgct gttcatcagg tgaaagagaa aagctattga 2767321 tgtactcttt ttccagacga atcggataca caaggccttc aatcgaaata taatagatgc 2767381 ccgtactgcc ttgatctgtg ccgatgacat aaaacccttg gctgtccttt gtccaaatcg 2767441 ggcgctgttc agcaccaccg atcaatgaat ctccaatcag cgcatccgct aaatgaacgt 2767501 ccagcatctc agtaagacat gtgaggcggc cttgttcgat atcatagagc cacgcctttg 2767561 agagcgtagc attcttatat tccttttcat ttccaagcaa agcaagatac cttccgtctg 2767621 gtgaaaatga gcttgatccg aatgagccgc gatgaggtgt aacctgctta agatctccag 2767681 actccagtga cattatgtaa acatcatgcg gcttgctggc atcatctgtt tcagttaaat 2767741 tagctgagaa aacaagccat ttgccgtcag gagaaaaagc aggatcacca tgatcagctt 2767801 tgtgacttgt cagctctttc atctcacccg actttacgct gacaagcaca agctgggcat 2767861 acgcacctct cgtcagccct ttgccgtccc gtttgtagga gaggccttgc acttcaacag 2767921 gttcatagct gtcctgctct gttttttctc ggtcatcaat gctttccccc tctcccaaac 2767981 tgacagtgac cagaatcgat tcaccgtccg gggaccatag cggctttgac acgccatatg 2768041 ggatatcagt cagttttctt gcttctccgc cttcagtgct catgatataa agctgtgccg 2768101 catcgccttc tcgatcagaa ataaaggcaa gcgtgcgccc gtccggagac catcttgggt 2768161 cggtgcttcg cttttctcca tgtgtccaag gaacagatcc tcccgttttc gtttcataga 2768221 tccatatatt tgatgtatac gaatctttct cttgatttac ttgtgatttt acatatgcgg 2768281 cacgggtacc gtctggggcg tattgaggat cggtcacaga gacaatcgct gtgatgtcgt 2768341 ctgcggttat cagctttttc atattcatct cctccttttt acatgtattt cgtttttcta 2768401 aataaaaact cctttatctc cagcaaaaaa aagcgccctc cgctgacgct gaggaacgct 2768461 tggcatgatc tatacacttt ttacttgata taaaggattt cgctctatta tacttccctc 2768521 tttcggaacg gtcaaagcgt ctacttcaca atgagggaaa tgaagcgcga gctgttcttt 2768581 tagctcttct ccctttcctt tttcggtcat gacgagaatc gttgggcctg ctccgctgag 2768641 agccgttcca tatgcgccct tcatctcggc gacgtgctct acttttgaca gctcaggcac 2768701 aagcatcgcc cggtacggct gatggaacat atccttcttc atgattttcc cgacaagcgg 2768761 ccaatccttg gacatgatcg cagcaatgag gatattgctg acagcacttg cttttacggc 2768821 atcggcatat ggaaactcct tcggaagcac gtctctcgcg tctcttgtca gcacttcata 2768881 aaaaggaatg acaacgacta cgtcaatgtc agcattcggg acgcggatca tttgggtctc 2768941 gtcatcctca tgcaggccga tcacaagtcc gccgacgaga gaagcgccag cattgtccgg 2769001 gtgtccttct tctagactcg ctaaatgcag cttgtccgct tcagacagct ttaagccgca 2769061 taattcatca gccagttcaa tggccgctac aatcgctgcg gcgctgctgc caaggccgcg 2769121 tgcaagcggg atgtcgctcc acaccttcac atggacagga ggcatttctt ttccgtacaa 2769181 atctgcggtc cgtttagcca cttggtagat caggttatct gtacccgccg gaattccggc 2769241 gactgtttct gtttcagcct caaaagacca tttgtcgctt tcaaagacgg tcagcttcaa 2769301 atatctgctg agcgccattc cgactgaatc aaagccgggg cctaggttag ctgtgcttcc 2769361 gggaacagtg acagagaaca gcatgtcggc ttcgttcata cacgggccgc tccttttaca 2769421 tattcaagga tgctgtcttc atcagtcggc aatgtgacag gcttgatttc tgaaatgtcg 2769481 accgctgtgt tcggatcttt cagtccgttt cctgttaaca cagctacgac cttgctgcct 2769541 ttcggaattt ctccggattt cacctgtttc agcactcctg cgatagacgc gcaagaacct 2769601 ggttctgcaa acacgccttc tacacgggcg atcagctgat atgcgtgaag gatttcatca 2769661 tcagtgactt cgtcaatttt cccattggat tcctcggctg cctttacagc tttgtcccag 2769721 cttgccgggt ttccgatacg aatggctgtc gctattgttt ccggattttc aatcacttca 2769781 ttgcgcacga ttgccgccgc accctcagct tcaaagccgc gcattttcgg aaggcctgtg 2769841 ccgtttttct catgatattc cttgaagccc ttccagtacg cagtgatgtt tccagcattt 2769901 ccgaccggga tcgctaaaac atcaggcgct tcccccagct gttcgcacac ttcgaaggca 2769961 gcagtttttt ggccttcaat gcggtaaggg ttgactgagt tgacaagggc aatcggtgat 2770021 ttctcacaga tggaacggac aattttaagc gcatcgtcaa agtttccgtc aattgcgata 2770081 atctcggctc cgtacatgac agcttgagcg agttttccaa atgcaatttt tccgttcggg 2770141 atgatgacaa tgcatttcat gttagcacgg gctgcatatg ctgccgcagc agcggaagtg 2770201 ttacctgttg acgcgcacat aatcgtgtca ttgccttctt cttttgcctt tgccacagcc 2770261 ataaccattc cgcgatcttt aaatgatccc gtaggattga cgccttccgt tttgacatga 2770321 agctcaattc cgagctgctc agacagcttc ggcaggtgaa taagaggtgt gtttccttca 2770381 tgtaaagtta gcgccggtgt ttgatctgtt acaggtaaaa attctttata ttgatggata 2770441 agtcctttcc acattagctc caaccgttcc cttctacacg atatgtgctt ttgacttctt 2770501 gaacgacttc caaatcattt aggttttgca ggatatcact gaaatcagct tctgatgtat 2770561 gatgtgtgac aattacgatt tcagctaact catcatggcc tttaattggc agctgaagga 2770621 ttttttcaaa gctcacgccc cgctctgaga acacagatgt aattttcgag aatgaaccaa 2770681 cctcatcttt tacatgaatt cttaaaaact gctgtgcata aatgtcagac ggcgatttca 2770741 tgtttttctc atattgcggt ccgacaaagc tgttgccggt tacacctagg cgcatatttt 2770801 tcatgacagc gacgaggtca gaaacaacgg atgtcgctgt cggcatgctt ccggctcccg 2770861 gcccgtagaa catcgtctca ccgacagcct cgccgtatac ataaacagcg ttaaactcat 2770921 tatgaacagc agaaagcgga tgatggtcag gaagcagtgt cggctgtacg ctgacctcga 2770981 ttttgctgcc gtcacgctga gcaatcccga tcagcttcat tgtatagccg aggcgtttgc 2771041 tgaagctgat gtcctcgtct gtaatttggg agatcccctt tactttgacg tcttccagat 2771101 ccacgttcat cgagaagccg aggcgcgcca atatcgccat tttccgtgcg gcgtcaagcc 2771161 cttccacgtc agaagtcgga tcagcttcgg caaaaccgag atcctgcgct tccttgagca 2771221 cttcctcgta tgggcttttc tctttgatca ttttggttaa gataaagttt gttgtgccgt 2771281 tcacaattcc catcattttt gtaattcgat ctgatgagag gccttcctct aacgtgcgca 2771341 gaatcggaat cccgccggca acactggctt caaagtagat atcgcatcca ttttccttcg 2771401 cttcggcaag cagctcggag ccgtacacag ccattaagtc cttgtttgct gtgacaacat 2771461 gctttttcga tctcagcgcg tcgaccaaat attgttttgt ctgttcaacg ccgccgatca 2771521 cctcgatgac gacatcaaca tctggatcat caatgacatc atacacttct gtcgtgagca 2771581 cttccttcgg caaatctact tctctctttt tctctaaatc ttttacaagc acttttttta 2771641 tcgtaaccgg acagccgacc tgatgcataa gcttatcctg atggtcttga ataattttaa 2771701 cgacaccgct tccgacggta cctaaaccta aaagccctac acgaatcgct ttcaaaaaaa 2771761 ctccaccttt cttttgattg tcctcttgga aaagacaatt gttaactcaa cacagacata 2771821 taagttacaa acattatata agcccgctcc tgttttgaca agacatcatt aggctgaatt 2771881 ttgcgaatgt aaacgcttaa cgcattgata tgacaagatt ctttattttc taattatttt 2771941 tgtcagattt tctcctcacc ttgagctgcc tttgccgagc cagctgacgc gtggaacaaa 2772001 cagcttctgc gcccgcatat tcatgaattc ctgcgctgta ttgagaaatt gttcataacg 2772061 cccacagtca ttaagaatga agtcaagctg ttcttcaaaa taatgctttt ctgattctga 2772121 tgacatgtaa tagctttcta cgatttcaaa ataatgaagc gggaaaagca gacggctgta 2772181 taaaaggcgt ttcgaaaatg aagacagcgg tgtgacttgc tcgtattcct gtaaaaagag 2772241 aaagccctgc tgattaaaat cttgtctgtg atgcaaaaac gtatgcctca tatattcagc 2772301 caaatcacgg gaagcgtggt caaacaccca atccgccgga atcctgatca atgattccgg 2772361 tgaccatgta tgcctttcca tccgctgatg gcatatcgtt cctgaatcag cggcttgggg 2772421 cttgtcatcc agctcagtgt ccactaaata ttgtatcgcg ttttctgaca gtcctaaata 2772481 atatggaaat gattcgatca tttttttatc gaatggctca tgcggagggg tctgaacctt 2772541 tctctgccaa aatgcttcca gctgatcaat tcgttttccc cacagatcct tccactggcc 2772601 gattcttccg gccgccttca cctcatatgg atatcctcgg ccttttcggt gaaattccgc 2772661 aagctccgct ccaatggaga acgccctgtt tgaataaggg ggggccgcct tcagcagagc 2772721 gtacgttttt ccctcatgtt caaatgtcag ttcaccttct tttgtaaaga taaaaaccga 2772781 aacgtatggg tcactttgtt cttgtaaata ctgactcatg taataaagct ccgccagctc 2772841 tgtttctgag aattgggaaa cggggacaat cagaaagtat gaattaggcg tctgaaagca 2772901 ttgatatgtg tgctggtaca tggaaagctg cctgatgtga atgccgtatt tttcttttat 2772961 tgtacctttc accatgatca cctgcctgtt gaattagggc tcatcacatc gtagtcatac 2773021 acagccggaa ttatgaatac atattttaat ccgaagaagg cgcaagaaaa agtcgtaaac 2773081 ttctcaagca ttttgtataa actagtaaaa aagattgggt gaagctgatg tcagaaaacg 2773141 aacaattcag tcagatggaa gctaaagcaa gagcacggat gaaggagcgc ggcgttgagg 2773201 tatcagacat tgccgagctt gtcttttttc tgcagaaaaa atatcatccg gatttaacca 2773261 ttgatgaatg cacgctgaac gtcaatcgtg ttctcgcaaa acgcgaggtg caaaacgcga 2773321 ttttaacggg cattgaattg gatgttcttg ctgagcagaa aaaattgtct gaaccgctgc 2773381 aaacgatgct ggaaatagat gaaagcctat atggagtaga tgaagttctg gcattttcca 2773441 ttgtgaacat ttacggatcg atcgggttta cgaactacgg ttacatcgac aaagaaaaac 2773501 ccggaatcct taaacgattg aatgataaat caaccggtga atgccatacc tttttagatg 2773561 acatcgtcgg agcgatttcc gccgcggctt caagcagact tgctcaccgc gcgcggcata 2773621 cagaataagg gcaccctttt agggcgccct tttttcaaat gtatggaatc cattcagtca 2773681 gagagtcaat ggcgtgagtc ggtttttcca tatcgtctgt catatgttct cttttcgtta 2773741 cgcctgtgtg aacgagcagc gtatccatac ccgcgttaat gccggccata atatcagtgg 2773801 cgtagttgtc gccgaccatg agtgtttcag acacatctgt gccgagaacg cgcatcgcct 2773861 gctccataat aattgattcc ggcttgccga taaatacagg ctgtacacct gtagatacgg 2773921 ttaacaccga tgtcagtgag ccgtttcccg gcaggagccc tctttcagtc ggaatcgcaa 2773981 tatctccgtt agtggaaata aagcgggcgc catttctgat tgccaggcag ccaacagcaa 2774041 atttttcgta tgtaatggaa cggtcgatgc caacaacgac aaaatccgcg ttttctccgc 2774101 caaatgtcag gccgttttct tcaatcgcct ggcggattcc ttcctcccca atcacataca 2774161 cagacgcgtc ttttttctgc tgtgcaatgt gctgggcagt tgccatgctg gtcgtgaaga 2774221 cctgctcttc tgttgccgga atatcaaaag acacgagctt gtccgctacc tgcttcggtg 2774281 tgcgcgaaga gttgtttgtc acgaaaagat aaggaacgcc gcgatctttc agcgttctga 2774341 caaattcaca cgcctcctcg attttttccg tgccattgta catcgttccg tctaaatcaa 2774401 ttaaataccc tttatatgtt ttcatatcca acactcctgt ggctttccag ttgttattta 2774461 aacgcggaaa caggtcctag ctctgtttcc aaatagcttc tgatccgttt cgggaagtcc 2774521 tgaagagctg tttgatgcgc cttgatcagc ctgtaaagct cgccgctgtc agcgagcaga 2774581 tactgttgaa ccaacgtttt gcggtaggcg atcaattttt tgagctcatc accctctttt 2774641 tccgtgacaa ctttctcatc aacaagtata tccataatgt cgtcatagct gcccgggtcc 2774701 cgcataataa agccgtcaat catgtcattg cctgtatcca aaatgcattc gattaacaga 2774761 tggcctatac gctgaagtgc caattccccg atttcagact gccagtctgt ttgtgagtca 2774821 aatagcgcca gctggtgctc gaagaaccct agtgtttttt cgattttgct tctgtcaaca 2774881 aaatacatga cagcatcccc tttgtgtata tttattttct gatccgtttc aagacaaaat 2774941 acgcacagcc gaaattgcag tattcgtaaa tatattcatc taatgtgctg attttcgttt 2775001 cgaaggttgc cttttgattc tggtcgtcaa agaagccctt gagccttaac tgaccgtatc 2775061 cccagtctcc cacaatataa tcgtatttat ttaatatatc ggagtagcgg gctttaaaag 2775121 cctcttcgtt gaagccgtct ttgaaattgt gcaccaattc aaattcggca ttttgaataa 2775181 gaatcatgat ctcacctctt ttttcactca ttcctatcat aattcattgc cccgtcccca 2775241 tcaattgcta aagaataaat catgcgattt ggctacccta cacatgagga gggattgata 2775301 aatgaaacga accgctgtca gcctctgcct gctgaccgga ctattatccg ggtgcggagg 2775361 cgcaggattg gataatgccc aaaatgtccg gaatcagacg cagaatcaaa ccaaacccat 2775421 tcatgtgtcg gaccgcaacg aggcttttaa caggcataat gagaacgaac aatttggcta 2775481 tgtccgctat caaaaagaac aatttgacgg agaacagcag aaaacgccgg tgatgaaccg 2775541 ggaagaaacc gctcacatga tatcaagttt aacggttcag ctcccccata ttcaagatgc 2775601 tgcgacattg gtgactgacc gagaagcgct tgtcgtatac aaaaccgatt ctaaaaaccg 2775661 ggagctgacc gccgatcagg tgaaaaaaac agcggcttct gtgataccgc gatactatca 2775721 cgtgtatatt tccgataatc caaaccatat gcaatccgtc gaaaattaca gcaatctcgg 2775781 ctctggttca agggatatta gagagatcat gtcggggacg attcaagaaa tgaaaacctc 2775841 cccgcaagga agccctgtct cagagaatga aaatgccaat ggagaaacgc gtcaggacat 2775901 gaaaatcgat aggaatgaca aaaacgccag atgatctggc gttttggcat tatgcttgtg 2775961 cttgacgctt tttagatgct tcgtttactt gttcatccgc atggtaagag gaacggacaa 2776021 gcggaccggc ttcacaatgg ctgaagcctt tttgcatcgc gatttctttt aattctgcaa 2776081 attcatcagg atggtagtat ttttggactt tcaagtgttt cttcgtcggc tgcagatatt 2776141 ggccgattgc cataatatcc acgttgttcg ccaagaggtc gtccattact tcaataatct 2776201 cttcttttgt ttcgccgagt ccgatcatga tacttgattt tgtcggaatg tcaggctgca 2776261 tttccttcgc acggcgcaaa aattccaatg aacggtcgta cgtcgcacgc gcgcggactc 2776321 ttggcgtcag gcggcgaacc gtttcgatat tgtgattcag gatgtctggg cgtgtatcca 2776381 tcaaggtttt taggttatcg tagtttccgc ccatatcaga cggcagcacc tcaattgttg 2776441 tgaacgggct ttttctgcgg atcgcacgga cagtttccgc gaaaatgcct gccccgccat 2776501 ctttctgatc gtcacgcgca acagccgtaa tgaccgcgtg tttcaaattc ataagcgcga 2776561 ctgaatccgc tacgcgttcc ggctcttgca gatcaagctc agttggaagg cctgttttga 2776621 cagcacagaa acggcatgct cttgtacaaa cagaacctaa aatcataaat gtcgctgtac 2776681 gtctgaccgc ccagcattca tgaatattcg gacactttgc ttcttcgcat acggtatgca 2776741 ggttgttttc ccgcatgagt tttttgagcc ctgtatagtt ttcatttgta tttaatttaa 2776801 ttttaagcca ttcgggcttt ctgaggtgtt cgtctttctt tgccaattcc catcatctcc 2776861 aatatccaat atactcaatt tctgacacga aacattctga aaacgagaaa ggtgcaggtt 2776921 ttagttctgc aacaaaaata atgtttttct aactaaagaa agtcttttct ttagacactt 2776981 taacatagga aaaatttctc gacaagggaa gatgattact gacattttta agccgggttg 2777041 ccgcaaacta tgtgtattca atatgaaagg agattatttt gtgaaagttt tgttatccgc 2777101 tcttcttctc cttttgtttg catttgagcc ttctgcgtct ggaaaaaaac tttcagatcc 2777161 agtgctgtcg aaacggatgg aattatatca taaaatcgaa gctgtgacgc agatcccttg 2777221 gtatgcgctc gccgctgttg atcaatacga agaaaacgtg cggagcaacc ggaaagatct 2777281 gcctgaaaag gcgggaatca tcagcatcta tatacccgat gatatctgga gcgggcctga 2777341 aaacccgaat ccgaaagacg atgcgccgtt aagcattaaa gtgtttgacg gaatcggaat 2777401 ggatggcgat ggagacggga aagccgaggt cagcaacgat gaagatatct tgtatacgtt 2777461 cagccaatac ttactgtcgt atggcacaga tgaagacaac atccggatcg ggctttggaa 2777521 ttattaccgg cgtgatcaga cagtggggat tatatctgaa ttcatgaagc tgtttaaagc 2777581 ctacggccat attgatctgg gcgagcatgc attcccgctt ccgatcagaa ccgattacag 2777641 ctaccgaagc acgtggggag atgcccgcgg cttcggtgga aggcggattc atgaaggtac 2777701 ggatatcttt gcccattacg gccttcctgt caaatccaca tgttacggcg tagttgaaat 2777761 gaagggctgg aaccgcttcg gaggatggag aatcggcatc agggacatta acaatacgta 2777821 tcattatttt gcccatctca atgggtttgc caaagggatt aaaacaggac aaatcgttga 2777881 gcctggccaa gtgatcggat cagtcggcag ctccggatac ggcccgccgg gaaccgccgg 2777941 gaagttcccg ccgcatctgc actatggcat gtacaaagat aacggaagaa ccgaatggtc 2778001 atttgatcca tacccgcatt tgagggcgtg ggagcgatat gaataccaaa aaaagaagta 2778061 acaaaaagcc gcctcttcaa caggcggctt atttgctgct tttttctttt tttgaatcgg 2778121 caccgttttc tttgctgctc ggaagctgga cagaaggcgt gacacccgag ccgccgcttc 2778181 cattataaaa ctgcggcact tcgccctgca ctgctttaat cgatacagga acattatttg 2778241 tgacgacagc ggttttgctg gcaaatggaa tgatgacctt cactttaatt tcgacaaaga 2778301 tgctgatatc aataagtgcg ttatttatgc catacggctt gattttggtt ttgacatctg 2778361 taaaagcgtc accgattaaa ttgaaccgga ccgggatttt cggcccgagg tttccaagaa 2778421 ggctgttgcc ggttacctgt cccagcggaa tgttgatcat aatgttttca ctggcgccgc 2778481 tgtgtccggt atgggtttcc atctctttca aatgagcctg aagctgcttt gtcacttttg 2778541 ttttcacact gtttacaacc tgtgtattaa aatcgattgt cgttaagttt ccgttttcat 2778601 cagaattcat ttgaaacata tctttcatat tttcactgtc agacatatag tcctcaatcg 2778661 aatcctggat cacctctgtc gctatacgct tcgtttccat ctcgccgatg tccattaaaa 2778721 caggtttgat cgagccattg atcatccaaa ggctgaccgt tgttgacagg ataaaaaaga 2778781 caacggacag gagcatcacg taacggaaag gcaaaggtcc tctcttgcga aaagggccgc 2778841 gatatcttgg caagaaaatc cccccttaca tatcacaatg tatgcttgta agaggggaca 2778901 tagtaatagc cggggccaat ttattttatt tcatcatttt taaaagcgct tctctgccgc 2778961 tcatgccgac tttgatgcca agatcttccg cagcgtacgt gacggattct aaaggtgcgt 2779021 ctaacagctg gtcaatggtg cggacaccaa ctgcgcgtcc cgccacgatg ccgcgctcct 2779081 ttaatttttc attcagcagc gccacatcaa gcgcgccgca cataatgtat ccgtgatcat 2779141 tggcgacggc cataaaattc gttttgggaa gctttactgt cacagctgta aaaggctgtc 2779201 cttctatcat gatcggtgtc aggtttacca cgtcaaccac tcccttcatt catcacttta 2779261 tgatgaaggg cacagcttgt tgtgggctga ctgccttatt gtgcaagctt ccaagcaagc 2779321 agatcccgca aaaattccgg cataaaatat tctttttctg cagcgtcgcg aatcaacgga 2779381 aacagtttgc cgagcgtaaa catatcaagc accgcaacgg agtattgttt atgtttttca 2779441 atatcttccc cgttcagtgt gatccgagtg acgtgggtga tcccgtcatc gagccgtttc 2779501 gtttctacct caacgccggc atacaccatt ttccccatca cttctccgcg gaagccgagt 2779561 cctttgatcc ggagctgctc catttgttcg gaagcggcat ggacaatggt ttccttcagt 2779621 tcttctcccg tcaggcggac agccaccggg ttgatcggat gcggacagat gcggtgcaga 2779681 tccagctttg tcacaggacc tgcttttagc ggaccgagaa tgacacctga attgaccata 2779741 ctgatgtccg tctcgcacca ttcctttaag gcgtatgcca aaagcaaagg cagctctgat 2779801 tcttcaaacc acttcacctc agcatcttgt gcaagctctg caacggcatc ggacagtttc 2779861 tcctcggctt cacgttcttt ttcattgaga aacgctttag tttctgcgga ttctcctgtc 2779921 cattccgcca tgttctgcac agaagccgtt ttgctgttga tgcttcgctg tacgctgtcc 2779981 accgtgattt ctacacagcc gacataatgc ccgtatttct cggcgctggc cagcagtacc 2780041 ccattaacca cttgtccatc ttcgagcaaa tgatgggtat gtgattcgag gattacatca 2780101 atctcaggca ccgcttcagc cactgcttga tcatcaagaa tgcctaaatg tgacagcaga 2780161 acgataatat cagcctgccc tttcacttcc agaatggttt cctttatgct ttcaagggca 2780221 tccgtaactg tccatcccag cttgtcatat acaggataat acggcacagt tacacctaag 2780281 aaagcaatgg acataccgtt tttcaatgat ttgatatggt aaggcaccgc ccaggacgga 2780341 cggtttccat ttttatcaaa caggttagag acgatgacag gaaattcagc atgatcatat 2780401 aaggcagcaa gctcttcatg cggaagcgta atcccttcgt tattgccgat cgccgctcca 2780461 tcaatgtgaa ggcggtttaa gagatcgaca ttcgcttttc cgaatgtcgc ctctgtcacg 2780521 aattgaaaac gatcaagatg atcgccaata tcaaaaacga gcgtctcttc gccgtctgac 2780581 tgatgctctt ttcttttctg ctcgatataa tctacaattt tcggccagtt ttcaaaatgg 2780641 ctgtgcaaat catttgtatg atataagcgg agcttctcct tcataatatc tctccctaat 2780701 cgttcagctg aaaatgcctt cataaatgag ctggcagccg atcaaaatca atacgatccg 2780761 catgatcata acgatcgttt tcgtctgcat ttttctgttg atggcggcgc caagctttcc 2780821 gccgaaccaa gcgccgggca caagcgcgag ggcgtacagc caattgacgt gcccggaaat 2780881 catatgtgaa acagaccctg tcatagaaga caggaaaata ataaacatgg acgttgccac 2780941 cgcaaccttc ggcggaaaca gaaataacag catcatcgcc ggaaccatca gtgatccgcc 2781001 gcctataccg aaaagtccgc ctaaaaaacc gacaacaaag gcaatggcaa taccgacaga 2781061 ggcctgatat gagtacgtat aaggctcacc ggcatcatcc tgaaatgtcc ggataattcc 2781121 tttgtgcgct ttgttgattg gccgggcttt cgctttcagc attaaggata atgaaatcag 2781181 aatcataaaa atgccaaacc aaacggaaaa cgagtttgaa ttgaacagct ttgacacgta 2781241 agccccgatc atgctgccgg gacccgaacc gataaagaaa atgagtccgc tcttataatc 2781301 aactgtttta tatttaatat aagccaaagt tgaagaaagg cccgtaaaaa taatgaccaa 2781361 aagcgaagtt ccaatcgcaa cctgcggcgt cacatcctga aacagctgcg tcactgtgct 2781421 taaaaacatc agagatggca caatgacaat tccgccgcca agcccgatca gacttcctac 2781481 cgtacctgcg attaatccca gtacgaccaa aatcacaaac gacatcaatc aaaacctctt 2781541 ttctaaaata aatcgagctg tctcggagca agtccgctgt actcgatatc aagcagttca 2781601 agcatctgct tgccattatc cgcagcgtca ccgccggaat tgttgttgaa caggacaaaa 2781661 acatccttac attgctgctg caattcattc aggtgctttt tccaatcctc cagctcctgt 2781721 tggttgtagc ggtataagta cctgacctcc cgccagtttt tcccgccatc aggcttcatc 2781781 cagccctgct tgttgcgtcc gtgaaacctg acgagcgttt tgttttcatc ggtcgcgcgc 2781841 aacacggtcg gaacgctgcc ttctccgatt tgcggttcat cacagacact gtgaatccag 2781901 ccttccgctt tcataaatga aagcgtctgc tcataaaatg gcggcgagaa ccaggaacgg 2781961 tttctgaatt caagcgcgca aggaatatct cccatttggt gcttacacca tctcaaatag 2782021 gcgacattct ccttcttgca gtcaaaccac ggcggaaatt gaaacagcac catggcgagc 2782081 ttattgctat gtaaatatgg cgttaaagac accttaaacg catcaaacat ctcctctttt 2782141 gagtcaaagg gaatttcgcc gcgctgatgc cctgtcatgc cctgatatgc tttcacgata 2782201 aattggaagg tttcgggcgt ttccttcacc cacttttcat tattgcgcgc cggctgaatc 2782261 gcgtaaaagc tcgcgtctaa ttccacgatc ggaaaatggg aggaataggc ctgcaatttt 2782321 ttctggctgg ccgttttcgg cggatagatg ctgtcatgat ccccccatcc cgtcagtccg 2782381 atataaatca cactcattca cctctcttcc agtttatcac acgtgttttc aggtttcctc 2782441 ggaaatgctg ttcatatggc gggaaaatgc ctcacgcaaa tgctgatatt gttcctcatt 2782501 cgtatctaaa aacgcctctt ctcttgagga aggaatgtgc tgatattcaa taggcgcctg 2782561 aaactgctca ctcgtaaaat cgtacaccac accattgatg ctgttataaa aatgccagct 2782621 ctcatcgact cttgttttga aaatcgtgcc gccgaaatgg tcttgaatca ccaatgccgt 2782681 cacgccgcat tggccgcatg acgggcattc ttccgtccat ttagagctcg aatggcgcga 2782741 ccaggattgc ttaagtatgt atttgacatg ctccattgcc tccgcctcct ttaaaaaaag 2782801 ataccacgtt gatgagattt taaaaactag aacggaggaa atcaaaaaac ccggcggtaa 2782861 aatccgccgg gcttacgaag gaacgaccag agctccgtca atttcagtga ctttttcccc 2782921 atcattgtac acgcaccggc ctttgctgta agtggccgaa atgctgcagg gaaatgtatg 2782981 tccttcgtaa atgctttttt tatgctttgc aaacatcgat tctcttgtaa cagtgtacgg 2783041 ctccatgctg acgagcacga aatctgcatc acaccccgcc tcaagccgcc cttttttctg 2783101 aaggccgaat cgttttgcag gggccgccgc tgtccattct gcgatggttt caaatggaat 2783161 ctgatgctca agcgccagtt ccagcattcc taataaagtg aactgcccgc cgctgattcc 2783221 gccccatgat aaaaacatgt tatcctcccg cttcaaggat ggacggcaag gggaatggtc 2783281 tgaggaaacc atgtcaatgt ccccggcaat gagcgtctcg atcagcgtct cttttgattg 2783341 ccgtgaccgg agcggaggcg cgcattttgc gacagagccc ctttgccgta aatcgtcatg 2783401 gctgaacaag acataatgcg gacatgtttc aaccgaaaca tcaagacctt cctgtttcgc 2783461 ctctctgatc agccggaccg ctttcgccgt gctgatatgg acaaaatgaa ccggacagcc 2783521 tgtcaccttc gcatactgaa tcgtgcgata caccgcttca acttctgctt cctccgggcg 2783581 ggaggcggcg tacgcatccg catccacctt tcctttattg gccaaaacca tctgcaagta 2783641 gcttgtgatc gcgtcgcttt ccgcgtggag agcgaggatt tttcctgcag ccgcgatttc 2783701 tgccatgcct ttgagcaatg tccgttcatc aacagagcgg aactcatcag tgcctgactt 2783761 tgataaaaac gctttaaacc cgatcgctcc cgcttcagcc atcggacgga tgtcctcgat 2783821 atggcctggc acaaggccgc cccatagcgc aaaatccacg gcagattttt gcctgcctag 2783881 ctcagctttt gcgagaagat gctctgccgt cacggttgat ggaatacagt tgagcggcat 2783941 atcaaaatag gtagtgcaac cgcctgcggc catcatttga gaacctgttt caaacccctc 2784001 ccaatcctcc ctgcccggtt cattaaaatg aacatggcaa tctatcacac caggaaacac 2784061 gtatttcccg tctgcctgga tgatttccgt cccgcttgct tcaatgtcag aacctatctc 2784121 ggcaatgaca ccgttttgaa ctacaatatc agcttctata acgccatctg gcgtaactgc 2784181 cttcgcacct tttatcacca tatcgtaagc catattgatc cccccatgtc aggatgacga 2784241 ttttccatgt cagtttatgt aacacaacca gttctatttt caacagttta ctgctactat 2784301 gatcgtatta catcagcaaa accgctagaa ttcctattga aaattattca ccttaaccaa 2784361 tgtttttata gaaaaggaga atgcgctatg aatattcttg atgtgatgaa aataccggct 2784421 tttgaaaacg ccaatttaat cgctggaaaa gcaggagggg aaagagaggt tcagcatgtc 2784481 aatatgatgg acgctccgga tatcgtagac tttttgcata agaatgaatt gctcgtcacc 2784541 accgcctatc acctgaagga tcacccgcat caattatctg aactgattcg gcaaatggca 2784601 aaacgcggct gcgcgggcct cggcattaaa acaaagcgct atctggaaga tatcccgaag 2784661 gaaatcatcg aactggccga ttcatatgcg tttccgatca ttgagcttcc ggaacacatc 2784721 cgactcggcg atattgtgaa tgccacactc agccatattc tcgatatgcg ttctaacgag 2784781 ctgcagcaag ccatttacgc gcacaaaaaa ttcacaaacc acattatgag cggcaagggg 2784841 ctgcaatccc tcctcaaaaa ggtgtcagac atccttcagc ttcccgtgct gctgcttgac 2784901 cagcatgcca aaatgctgtc tgcgtctcat cagatttcag ttgagaccga aaagctgaaa 2784961 ggcaccctga ataccgtatc cgggccattt ttcacttgtt tctctacaat ctcagatcag 2785021 aaaacatatt ctgtcctgcc tatttataat cacgaaaaaa actgcggcta cctgctgata 2785081 cccgacatgg tgcaggcagg cgacaaagga ttgatcctca cgattgaaca agcggccaac 2785141 gtcatttcct ttgaactgct gaaggaaaat gcgctgaagc agttcagccg gcgggcccgc 2785201 aatgagtttt tcaacaattt tattgagcgg accttttctt cagatgacga aatcaaaaac 2785261 cgggcgaaag aattcaagct gcgctgggat caaaaataca tgtgcatcgc cggcaaactc 2785321 gatcgcaatg acgaatcaat cagctttaca gaaaatcagc tcgcttccga cagcgtattc 2785381 gaatttcttg aaggtgaatt atcagccttc ccgtttccac ctcacttctt tatgaaagga 2785441 aatgtcggca ttattctaat cgaggcgaca gacagctgga gtgaaatgca cgcctcggtg 2785501 atcagctttt tagaacagtt tcaaacacag gtcagcgctc aatttaaacg aaccgtgtcc 2785561 tttggcatca gcaatatctg ccaaaagctc attgatgttc ccgacgcttt cacagaagct 2785621 tctgatgctc tgcaatcggg gcatttgtca agaagcaccg catttatcca ggtgtatcac 2785681 gccaaagatg tgcctgagct tctgcgcttg ctcccagttg aggatttgaa gaaattttac 2785741 aactccacgc ttcagagcct cgctgaaaaa cagcaggagg atcaaagcct gcttcatacg 2785801 ctttccgtct atttagagac acactgccaa atttcagaga cggcaaagcg tctgtacgtt 2785861 catcgcaata cggtcatata ccgccttgaa aaatgcgaag agcttctggg gaaaagctta 2785921 aaagatcctg aaacaacgat gcgtttgcgg cttgcattac gtatgcagcg gctgatcagc 2785981 taaagtttgt tacattttct tacaaaacga atcgtttttc gtcactttca gcaatcacac 2786041 ctgtcttttt cagctactgt atccaatgac acccctcgac cggaacgata ttatgttact 2786101 aaagttcaca tacagggagg gactatagtg aaaaaaagat cgtttaaggt gtttacactt 2786161 agcctgcagc atgtgctcgc catgtatgca ggtgcgattt tggtgcccct gcttgtcggc 2786221 agggcgctga atgtaacaac tgaacagctg tcctacctat tggcgattga cctgttaaca 2786281 tgcggcgtcg ctacgctttt gcaaaccttg cgcggaacat acatcggcat cgggcttccc 2786341 gtcatgcttg gcagttcatt tgtggccgtc accccaatga ttgcaatcgg cagcaattac 2786401 ggcattcacg cgatttatgg ttccatcatt gcggccggtg tgttcatctt tttgtttgcg 2786461 cgttttttcg gcaagctgac tgtgttattt cctcctgtcg taacaggtac cgttgtgacc 2786521 ttgatcggcc tttcacttgt tccgacaggt gtgaaaaata tggctggcgg cgaaaaaata 2786581 aacggcagcg ccaaccccga atacggttcg ctcgaaaacc ttcttctctc tgtcggtgtc 2786641 cttgttctga tcttagtcct caaccgcttt ctcaaaggat ttgcccgaac actgtccgtt 2786701 ctgatcggca tcgccgccgg aacagcggca gcagcgatca tgggcaaagt cagcttttct 2786761 tctgttacag aagcaccgtt cttccaaatc ccgaagcctt tttacttcgg agcccctgcg 2786821 tttgaaatcg gtccgatctt aacgatgctg atcgtcggaa tcgtcattat tgtggaatca 2786881 accggcgttt tttacgcaat cggaaagata tgcggcagac ctttaactga caaagatctc 2786941 gtcaaaggct atcgagcgga aggaatcgcc attctcatcg gcgggctgtt caatgccttt 2787001 ccttataata cctttgcgca aaacgccggc ttattgcagc tgaccaaagt gaaaacaaga 2787061 aacatcgtcg ttaccgcagg ctgtatcctt gtctgtctcg gactgattcc gaagattgcc 2787121 gcccttgcat ctgccgttcc tgctgctgta cttggcggcg cgaccgtcgt catgttcggc 2787181 atggtgattg cctccggcgt caaaatgctc agcacagcgg atctcaaaaa tcaataccac 2787241 ctcctgacca tcgcatgctc aatcgcactc ggcatcggcg ccagcacggc ccccgggatt 2787301 tttgctgaat tccccgctcc gatccggatt ctggtcagtg acggcaccat caccggaagc 2787361 ctaaccgcca tctttttgaa tctatttttc agcttgcgcg acaaaaaaga attaacagca 2787421 cagcaaacag aacttccggt attagaacat acactcgcat tagaaaaaga ggtgtaaaaa 2787481 agatgaagga acagcacaat gccttacagc taatgatgct ggggcttcag cacatgcttg 2787541 ccatgtatgc gggagccatt ctcgttccgt tgatcgtcgg agcagcgatc gggctgaatg 2787601 cggggcagct gacgtattta atcgcgattg atttgtttat gtgcggggcg gcaactcttt 2787661 tgcagctctg gagaaaccga tatttcggca tcggccttcc cgttgtgctc ggatgcacgt 2787721 ttaccgcagt cggcccgatg atttccatcg gaagcactta cggtgtccca gcgatatatg 2787781 gtgccattat cgccgcagga ctgattgtcg tcttagccgc gggcttcttc gggaagcttg 2787841 tccgtttttt tccgcctgtc gtaaccggat cagtcgtcat gatcatcggc atcagcctga 2787901 ttccaacggc aatgaataac ctggccggag gtgaaggaag caaagaattc ggctcactcg 2787961 acaacgtgct cctcgggttt ggcgtcacag cttttatctt attgctgttt tatttcttta 2788021 aaggctttat ccgctccata gcgattttac tcggtcttat cgcaggaaca gcggctgcat 2788081 atttcatggg aaaggtcgat ttttctgagg ttttggaggc gtcttggctt catgttccgt 2788141 ctctgtttta tttcggaccg ccaacctttg agctgccggc tgttgtcacg atgcttctcg 2788201 ttgcaattgt cagcctcgtt gaatcgacag gcgtttattt tgccctcgct gatatcacaa 2788261 accgcaggct gtcggagaag gatctggaaa aaggctaccg ggcagaaggc cttgcgattt 2788321 tgctgggcgg cttatttaac gcgtttccct atacagcttt ctcgcagaat gtcggcatcg 2788381 ttcagctctc aaagatgaaa agtgtcaacg tcatcgccat cacaggaatc atactggtcg 2788441 cgatcgggct ggttccaaaa gcagcggccc tgacaacagt gatccccacc ccagttctcg 2788501 gcggcgcaat gatcgtcatg ttcggcatgg tcatttctta cgggatcaaa atgctatcca 2788561 gcgttgacct tgattcgcaa ggcaacctgc tgattatcgc ctcttccgtc agcttggggc 2788621 ttggcgctac aacagttccc gcgttgtttt catctctttc gggcgcggcc tctgtcttgg 2788681 caggaagcgg aattgtgatc ggcagtttga cggccattgc actgcacgct ttttttcaaa 2788741 ccaaacagcc gaatagcgca gacataaaaa cgtaaaggaa gatgccaatg ttcacaatgg 2788801 atgacctgaa ccaaatggac acacaaacac tgacagacac acttggctct atttttgaac 2788861 actcttcatg gattgcggag agatccgcag cactacggcc gttttcgtcc ctttctgatc 2788921 ttcaccgcaa aatgactggc attgtaaaag ctgcggatcg cgagacacag cttgatttaa 2788981 tcaaaaagca tccccggctc ggaacaaaga aaacaatgag cgatgactcg gtacgagagc 2789041 agcagaacgc agggctcggc aaattagaac agcaggaata cgaggagttt ctcatgctga 2789101 atgaacacta ttatgatcgc ttcggctttc cttttatttt agcggtgaag ggaaagacga 2789161 aacaggacat tcaccaagcc ctgctggcaa ggcttgagag cgaacgagaa acggagttcc 2789221 agcaggccct tatagaaatt taccgaatcg cccgctttcg tctggctgac atcatcactg 2789281 aaaaaggaga gacgcaaatg aaaagaacca tgtcttatgg caaaggaaat gtatttgcat 2789341 accgaacgta tttaaaaccg ctcactggag tgaagcaaat cccggaatca tcttttgccg 2789401 gaagagataa taccgttgtc ggcgttgatg tgacatgcga aattggcgga gaagccttcc 2789461 tgccatcatt tacagacgga gacaacactc tcgtcgtggc aacggattca atgaaaaact 2789521 ttatccagcg ccatctcgca tcctatgaag gaacgacaac cgaggggttc ctacactatg 2789581 tagctcaccg atttttagat acctattctc atatggacac gatcactctg actggcgaag 2789641 acattccgtt tgaagcaatg cctgcatacg aggagaaaga gctcagcaca agccgcctcg 2789701 tcttcagaag atcgcgtaat gaacgaagcc gctctgtgct gaaagcagaa cgaagcggga 2789761 ataccataac gattacagag caatacagcg aaatcatgga tcttcagctc gtcaaggtga 2789821 gcggcaactc cttcgtcggc ttcatccggg acgaatatac gactctcccg gaagacggca 2789881 accgcccgct gtttgtctat ttaaacatca gctggcaata tgaaaataca aatgactcat 2789941 acgcttctga tccagcacgc tacgttgcgg ctgaacaagt ccgcgactta gcgagcaccg 2790001 tttttcacga gctcgaaacc ccttcaatcc aaaacctaat ctatcatatc ggctgcagaa 2790061 tattagcgag gttcccgcag ctcactgatg tcagcttcca atctcaaaat cacacgtggg 2790121 atacggttgt cgaagaaatc ccgggctcaa aaggaaaagt ctacaccgaa ccgcgcccgc 2790181 catacggttt ccaacatttt accgtgacaa gagaagacgc cgagaaagaa aaacagaaag 2790241 ccgctgaaaa atgtcggagc ctgaaagcct gatgggaaaa ctgacaaccc atattttaga 2790301 tttaacctgc ggcaaaccag cggcgaacgt aaaaattgga ttgaagcggc tgggcgaaag 2790361 tattatgaaa gaggtataca ctaacaatga cggcagggtc gatgtccctc tgctggctgg 2790421 tgaagagctg atgtcaggag agtatgtgat ggaatttcat gcaggagact attttgcgag 2790481 taaaaacatg aacgcagccg atcagccgtt tttaaccatc gtcaccgtcc gttttcagct 2790541 agcagatcca gatgcacatt atcatatccc gctcttgctg tcgccgtttg gttatcaggt 2790601 gtataggggg agttaagaag gaagcccgcc tcaccggcgg gcttcttttt gcacttcaat 2790661 taacttttga tcctaggaca gtacttgaag tgatccccac acttagtgaa acaacagcta 2790721 gaataaacat tcacctatat ttttcaggat aattgcctac gagaaaaata ccctgtagtc 2790781 ctttcattta taaatcgagg tttcaaacta ataagtcagc tcttagcagc cgagctccct 2790841 tctccaatcc tataaacaga ccgcgttttt tctcgaaaaa atactctgaa gacaattgct 2790901 gcgtttttaa tagttttgat aacgcgttct ctcttacacc tttagacaaa atattcattt 2790961 tttctttttt agacttaaat ctatgtcgaa aataatcgtt ggcatatctt atcctatctc 2791021 cactaaagga ggtgacatta tgggattcta caattctggt ggatacagtg gaaactctgg 2791081 ttactcaaac ggtttcggga gctccttcgc tttgatcgtg gtgctattca ttttgttgat 2791141 cattgttgga gcagctatct ttaattatta agtttaactt tccttgcctc cgccgtatcc 2791201 aacacctccc tgtccgacag acgccataag aagtttttat ggcgtctttg ctatgtgttc 2791261 actaatcttt ttgtaatcca gaagctgtca agttctacga gatttatcgt gtgttttccc 2791321 acaacgcttc tgcgtcttga tcgcgctgtc tgactgaggc taaaaaagtc cggcttttaa 2791381 aagccggact cccgtctacc cccgttcaac tctcttctaa tcctgcaagc tgaccgcata 2791441 atcccgccat acccggtaca ccggcacaaa ttccccgcca gcccttcttc tatatctttg 2791501 tcagaaggtt gaggggtttc ccgaaacaat gctttaagcg caatgatcat tcccggcgta 2791561 cagtagccgc attggaagcc gccttcttcc aggaaagcgg tttgacacat atccagctct 2791621 tctttttgaa gcccctcgat ggttgtgatg gaatggccgt ctgcttgata ggccatcgtc 2791681 atgcacgcat tggccagttt tccgtcgatt aaaatagagc aggctccgca gcggccgatt 2791741 ccgcaggaca cctttgtccc ggtcagctga aattcctttc taagcaggtc actcagatgt 2791801 gtcgtaggaa cggcagcaac ctcccacgcc tgaccattca cggtcatccg gaactgttcc 2791861 ttttttacag gaaatggccc ggcctctttt atgtccattg cttcagcccc tttctgtcga 2791921 tcgcttcaag caactcttct cttgaaattg gcagcttgtt tatccagcat ccgaccgcat 2791981 catgtactgc ctttacaatc gccggagtga tggcgattgt tccgatttca ccaacaccgc 2792041 gcggtccata tacgtctccc ttcattaagt cttctattgc aatcagcttc atgtcaggaa 2792101 catctttgat tccgggaatc aaatagtgat cgagattttc cgcagcataa cggccatccg 2792161 tcattttcgc ttcctccatc agtgtgtagc cgagtgccat ggcagcgccg ccttcaattt 2792221 gacctcgata tccctgcgga ctgacaaccg gacctgccgc aatagcgtgc tcacaatcta 2792281 tcaatttgac atcgcctgtt aacagatcta cctccacctc aacggcagcc gctccaaatg 2792341 agtagaggaa atggccgccc accacaggat caggcgttgt tggaaagtca aaggccgttt 2792401 cctctgccaa agggcctttt tcagccagct ccttatacgt caccacgagc gcctttgtgt 2792461 ttttgtcacg caagcctgca gcgccgggaa taagattttc cgctgaacag ccgctccatt 2792521 ctgccgcccg ttttttcaac tgagctagaa acggcttctt caaacgctgg atcgcgtgcc 2792581 acaccatgct tgtgccgcgg gatgctgtgg aggagcctga cttcggcact tttgcggtat 2792641 ccccaataac aatggaaata tcctctgcgg cacaacccag ctcctccatg acaatctgtt 2792701 caatcgctgc tagaatcccc tgtccgcatt cttcaaatcc aaacgaagca gtgattttgc 2792761 cttcactcga aagagacaaa cggcctcctg ccgcatccat tcggccaaac cccagcccgc 2792821 cgccgtgcat tgtaattgcc gctcccgtgc ctctttgcag atacccgcag ttccggcttg 2792881 tttttttaag aatgggagat ttagatatgg cattcaacac ctgtgccgct ccgtcagttg 2792941 gtgcaattcg atgctcaagc ggccccaagt catgcggttt tctgatattt tttcttctca 2793001 gctcgagcgg gtcgatgcca agcatgccgc tgagacgatc gagatgggtt tcgagtgcaa 2793061 atgtgatttg gttgccgcca aagccccgaa attcccccgc caccccgttg ttcgtaaata 2793121 ctgatattcc ttcagtccgg atattcggaa tacggtacgg ccccgcggca tgctcgacag 2793181 aaaaatcaag aacagccggt ccgagcgtag cgtaagcgcc tgtgtccgcc acaattttca 2793241 cgtcgtgcgc caatagattt cccgaatgat ctgcacccgt ttttatcgta atcttcatcg 2793301 gatggcgctt aatgccagaa cgtacagatt cctttcgtgt ctgatgaatt ttgacagggc 2793361 gtccgctttt cagggccaaa agcgcagcat acggctgaat attcagctca tccttccctc 2793421 cgaacgagcc gcccatcgga cttgacacaa ttctgatctt ctcttcagga atatcaaaaa 2793481 tacgggcaag ctggaaacgg tctttatagc cgtgctgggt tcctgcatac atcgtaaaac 2793541 ccccgtcgtc ttccggaacg gctacacctc cctccgtttc catatacgta tgcatctgcc 2793601 gcggcagctc ataggtttct tcaaagactg tgtcagatgc ttgaaaccct tcttccacat 2793661 caccgtttga aaaaaatgcg cggtgcagga tattcccgtc ctcatgcagt ctttgcgcat 2793721 tcggccgaag cgctttttct ggtgaatcca tgacttccag ctctttatac tcaacttgaa 2793781 tcagctccag cgccgcttcc gcgatttctt ccgtttccgc agcaactgcg gcgatcgcat 2793841 ccccgacata ccgcaccctg tcctcacata aaaccggctg atcagggatg acaatgccaa 2793901 atcggtttaa gccgggaacg tctttatgtg tgacgacggc ctgcacgcct tccattttct 2793961 cagcttttat ggtgcaaacc gacacaatct ctgcatgagg ataagcactt ctcagcacct 2794021 tgccatacag cattcctgga aagctgagat cggtcatata tttcaattcc cctgtgacct 2794081 taccccttcc atccggcctg actcttgacg gtttgttgat gatcatttat tcccctccct 2794141 cagccatcag ctctgccatg atgacgttgg cagcggcttt ttttctgtat gccgctgaca 2794201 taaaaacatc tgaggaaaac ggcagctcat ggataagtgt tttgtacagc tcatgcgggt 2794261 cccaccctgg tgccatccat ttcgcttcgc tgtccaataa tctcctagga gtgatatcgg 2794321 catggccagc ggcgaggcga atgctgccgt ctttcaaaaa acgtccagct gcaacagcag 2794381 ccgctccggt aaaagcctgg cgccttccaa gcttgtgata aaatacacgc tctccctccg 2794441 cccgcgggat gatgacacgc gtgacgatag ccgttctaaa gtcttcctca ctgagccaag 2794501 cgccaagcgg cagcctgatt agctcctttt gatatacgat aagctcagca ccaagcacaa 2794561 gcagaagcgg aatgaaatca ccgattttac tcgctatgtt gccgccaatc gtggcacggc 2794621 tgcgaatccc cggtgcagcg acagcggaag cagcgtcact gaaacagcta agcgctctct 2794681 taatcaaagg gttctttctg cattcattca gtgatgtgag ccccccgatc gacacgtggg 2794741 tgtcactggt gctgatccct cgcatttcgt caatcccttc aaggctgaca aggtgctgtt 2794801 tcggtagagt tcctttgtcc cactgaagct gaaggagcgt gcttcccgat gcggcacaca 2794861 catccggagc aagcttctct aaaagcgaat aggcctcatc aagcgctgcc ggtctccata 2794921 attgaatatt catccttgct tttgtcactt ggccgttcaa gacatcgccc tccttaccat 2794981 gtcatattcc tcgggtgtat caatatcgtc caactcaccg ctatcctttg cctccaaaac 2795041 cgctcctgct ccaagctgtc cgcttttcag gagcctgcga gccccttcat ctccctttaa 2795101 tccctttaca taaggaaaac atgtcgacga gaagtagatt ggcggggtga acgcccctaa 2795161 aaacgatgac acggcaaatg actcaggagc cagagccaca agggcattga gatgatcgac 2795221 ggaaagctga ggctggtcgg ctaacaaaat gacaatgccg tccgccccca tgctttctgc 2795281 ttttctcacc ccgctgctga ctgaatgccc ctgacccttt tctgcgtctt ggcaaacgtg 2795341 caggctccag cgtttttgaa aaggcggagc gtgatacggc gctcctatcc actcaaggga 2795401 ggcatgttct gtccgctcga cgaccagcac gtgatcaagg cgggacgaca gagcagtttt 2795461 caaggaaagt gagcctatgt tttctccttt tagcggcaaa gccagcttgt tttgtcccat 2795521 tcttctgctt ttgccggcag cgagaaacac gccgatcaga taggggcttc tcatacaacc 2795581 gccacccgtt ttcttgtttg aatgatttct gcaactacac ttaccgcaat ttcctcggga 2795641 ccttccgcac cgattttcag cccgaccgga ctgtaaaagt gagacggagg atgttttccg 2795701 ctcagcagcc gtttcgtgcg gtttgccgaa cccaacagtc caatataatg gaggttttga 2795761 gaaaataaga agttgatgat cgtttgatcg tgctgataat gatgggttgc cacaacagct 2795821 gcatcatgcg gaaaaaattg aaattcgcta agcatttgtt ccggaaaagc ggtgatcagc 2795881 tgatccgctt ttggaaaaag agaggatgta caataagcgg gccgccaatc cgtcacgata 2795941 acagaaaacc ctgtgtcagc cgccaaattg gccagcggta cattatccgg tcccgcccca 2796001 aacagaatga gacgcggctt cggttcaatt cgctgaataa acatgttagt ggtttgatcg 2796061 aaatgcggta aatgaagcgt tgaaacagta cgttgaatat cttgcagagg cgcgtccggc 2796121 cagttcccaa aatgtccgtt ctccgtcaga aataaataat gggaggattc aatctttata 2796181 acggaagtga cagctttgcc tgaatgaagg cagtccctca ctttctcata gtgccgcctt 2796241 ttttcctgag tgattcgctc tgcatgaaca tgaataatgc cattgcaccc ggctcccatg 2796301 ccccaagaaa gatcgtcctc cgaccgcatg tcgtagggaa tcagcgttga tgtgagctga 2796361 tcgcccagcg cactgattct ttggaataca tcttcttcca cacacccgcc gctcagcaag 2796421 ccaatccgtc tgcctttttt cttaaagagc atagaggcgc ctgcttttcg atacgcggag 2796481 ccttcaactt gaacaattgt cgccagtaca gcctcctcct ggtcttccag gagcgcatct 2796541 aacatcgtgt gaaaattccc caatgccgca tcctcctctc gaaaattgcc gtgagaaaca 2796601 actagttcag cgtgatttta taggtaactt gtataaagaa tagacgatgg aagaaaaaat 2796661 gactcatgat ttgtcagaaa atgaaacaca tagaaagagg atttgtaaaa agagtcaaac 2796721 gaagaaaatc agattggaga aaacacgaaa tcatatcgtt aaaaagcttg cggagttccg 2796781 caagcttttc tttacaccgc tgcctggcgg ccagcgtttt catacacatc cagcgctgct 2796841 tggagcgctt ttcctgcttc gattcctgcg ttatgtctga gaagcacagc ctctaacccg 2796901 gcaagcacga atagcacgtt ttcttttctg cagctgtacc ccatcgtgcc gatcctccag 2796961 atcttccctg caagcgggcc gaatgagctg gcgatttcaa tgccgaattg tgccagcagc 2797021 atgtcacgga cagactcgcc gtcaatgccg ccgggaattt cgacacaggt gacaacaggc 2797081 attttgcagc tgtcatctcc aaacaatctt agccccattg cctttatccc tgctgctaat 2797141 gcggcttcat ggtgccgatg ccgctcgaaa cgcgtctcaa gaccttcttc aagcaccagt 2797201 ctgactccct cacgtaaggc gtacagcatc gtcgtcgctt ctgtatgatg attgagccgt 2797261 ctttcgctcc aataatcctc aagctggctc aaatcaaagt agttgcttgt aattggccga 2797321 tttcccgaaa gtgctgccct gtcagcttgt gtcgcaatcc cgcgttccac ctttttgcga 2797381 gctgcaatca cgtccgccac ccgctcatta tatgtaatcg gcgccattcc tgaaggcaca 2797441 gacaaacatt tttgcgttcc gccgatggca gcgtcaatct tccattcatc gactttaacc 2797501 tcgcagcccc caatcgttgc gactgcatcg acgataaaca atgcatcctc ggtgcggcag 2797561 gcttcgccga tggctttcag cgggtgaatc cgtcctgtcg atgtttctcc atgcaccatg 2797621 gccacaattt tcggcttcac tttttttatc tcccgtatga tgtcctccgg gtcaaaaacc 2797681 gttccccatt cgcactccag catatgaaca tttgccccat atcgctcggc gatttcagtc 2797741 agcaaataac cgaaacggcc gtaaatggga atgagcacat catcttccgg ctctatcaca 2797801 ctagccagca ctgcttcaat tcccgcccgt gaagtgccgt caatcgggta tgcccagcgg 2797861 ttttttgttt ggaacagctc ccgaagcatc tccatcgttt cattcataat acctgtaaac 2797921 gccggatcaa attggccgac aaccggggtg ctcattactc ttaatacacg cggatcaacc 2797981 tcaacaggcc ccggtgtcat aatcgttctt aacggggtgc ataattctct tctgcctgac 2798041 acagccattc ctcctttatc agtaagccag tttgtataat aaatcagtca gtgcgcggac 2798101 gccgatctca agctgtctgg ctgacgtata ttccttcggt gagtggctga cgccgcctcg 2798161 gctcggcaca aacagcatac aagcaggata gcgccttccg atcatttgcg cgtcatgccc 2798221 tgctccgctc accatttcct cacagctgaa gccgttttct aatgctgttt caaaagccgc 2798281 agccttcagc ctttcgtcca tcggcacagg ctctatccgc atatattcat caatcacagc 2798341 gcgaattcct ttttgtaggc aaatgccgtt gatcaaagca accatgtctt gatgaaactg 2798401 ttccagcaca tgctgatgct gatggcgaat atcgattgaa aactggacgc ggcccggtat 2798461 gacattggct acattgggct ctgccgttat ttttccgcat gtcagacgga gctcatccgg 2798521 cagctcatcc gaccgcagca gcagctcatg aatgatacgg ctgctggctg cgagcgggtc 2798581 cttgcgccat ttcatggagg tggttcctgc gtgattgcat tctccttcga gcgtgacgag 2798641 atatcgtctc tgccccgcaa tacttgtcac gatgccgaga tcccggcctg acatttccaa 2798701 cgtcttcccc tgttcaatat gcagctcaac aaacgcgctg atatctgtcc tatatgctga 2798761 ctgaaacaca cctttgccaa aaccgctctc atgcatcgct gtttggaggg agactcccga 2798821 ctcgtctctt ggctcttttg catcttgttc tgaaaaaaca cccgtcatat tccccgaccc 2798881 ccaataggtc attggaaaac ggctgccttc ctcctcacat aaggagaccg cctcgagcgt 2798941 tttttttggc gctccgtatg tttccttgag ctgctttaac gcgagcattg ccgccagaac 2799001 gccataggcg ccgtcgtatt ttcctccatt gatgacagta tcgatatgtg aaccggttac 2799061 aatgacttca tccggagact gggtgcccga aagccttcca aacacattgc cgacatcgtc 2799121 gaatcttgtt tcaagcccga aagaagacat ttccgttttc acagcaagct gtgcgtccat 2799181 ccactctttt gtgtataaaa gcctcgttac gccgccatcc gcagacgcac cgtattgggc 2799241 gagccattca atataatctg tgatgctgtt ttttactgaa agcttctgct tttccatgta 2799301 ctcccccctc tggccgctat ggtgacttca ttatagaagg agcaacatga tagttcattg 2799361 acagattaac caaaaaaacg tttatttttt agccacagta tccatccagc aaccagatac 2799421 accctacatg tcacaactat tttgatgtaa aggtcaaaag aaaacacggt aaggaagaga 2799481 gccagcaaga gcgaaagaga gggtcaaaat gcctttcata tgaacaagct aagctggaga 2799541 ggcgatgttc gcggaacgga tgaaaacaga aatgccggca gcccgcaaaa acaggaccta 2799601 aagatatgga aacaggagat ttccgcctcc tccaaaggga ctaatttaca attttaatga 2799661 aaaatataca aaatgacact tctatccttt atttcaattt tagataatag atatgatctg 2799721 ataaaaggag ggcaagtgat gacaaaaaaa gcatggtttc tgccgctcgt ctgtgtatta 2799781 ctgatttccg gatggcttgc gccagcagct tcagcaagcg cgcaaaccac attaagcctt 2799841 aatgaccgat tggcgtcttc cccttcagga acgggaagcc ttctctcatt agccgccccc 2799901 gctgcaccct atgctgacac agatacctat tatgaagggg ctgaaggtaa aacaggagac 2799961 tcgctaaaaa gcaccctgca ccgtattatc agcggacaca cgatgctgtc ctacagcgaa 2800021 gtgtggaacg cgctgaaaga aacggatgaa gacccaagaa atccgaataa cgtcatcctg 2800081 ctctatacga atgaatcgcg ttccaaaaac ctgaacggcg gcaatgtcgg cgattggaac 2800141 cgcgagcatg tctgggcgaa atcccatggc gattttggta cgagcaaggg acctggtact 2800201 gatattcatc atttgcgccc ggctgatgtt caagttaaca gcgccagagg aaatatggat 2800261 tttgacaatg gcggcactga atatgcgaag gcacccggaa attattatga cggcgattca 2800321 tgggagcccc gcgatgatgt gaaaggcgat gttgcccgca tgctgtttta catggctgtc 2800381 cgttacgagg gtgatgacgg ctatcctgat cttgagctta atgataagac aggcaacggc 2800441 tcagctcctt atcatggcaa acaatctgtc ctgctcgaat ggaataagca ggatccggtt 2800501 gacgaccgcg agcggaaaag aaatgaaatc atttatgaaa aatatcagca caaccgcaat 2800561 ccatttatcg accaccctga atgggcggat gagatttggc cgtaagaaaa aggtgctcct 2800621 tttgaggagc acctttttct aatacacagc ctcttccgtt tccgcatcga aaaagacgac 2800681 gtggtccatt ttcactgaga gctggattga atcgcctgca tcgattcgcg tgtttccgtc 2800741 caggcggacc ttgagccgct cgtccccagc catgacatgc actatgagct ccgagcccag 2800801 attttcattc acttccacgt tcgcttgaaa cactgaatca aacaactggt catttcctgt 2800861 catttgtgtg atgtgctccg gccgtacacc ggcaatcatc tgttctccgg catatccctt 2800921 ttccttcagc cgctttgctt tttcttcagg aatatgaagc cggatcgaag aatttgtgaa 2800981 aaacagctcg ccatgctgct gttctatgat gcctttcaaa aagttcattc cgggagagcc 2801041 aatgaagcct gcgacaaaca aattggccgg gtaatgataa atgtcatgag gtttcgccac 2801101 ttgctgaatt tccccttcat tcatgacgac aatccgatct cccattgtca ttgcttcggt 2801161 ctggtcatgc gtgacataaa tgatcgttgc ctctaatcgc tggtgcagct tgctgatttc 2801221 tgtccgcatc gtcactctta gttttgcatc cagattagaa agcggctcgt ccattaaaaa 2801281 gaccttcggc tccctcacaa tcgacctgcc aagcgccacc ctttgccgct gcccgccgga 2801341 gagcgccttc ggttttctct tcagcaaatg ttcaatttct aaaattctgg ctgccgcatg 2801401 aacccgctcg gcaatttcct gtttcgccat ctttctgagc tttaatccaa acgccatatt 2801461 atcaaaaacc gtcatatgcg gataaagcgc atagttctgg aataccatcg caatatcacg 2801521 ttctttcggc ggaagatcat tgacccgctc cccatcaata agaagatttc cttcagaaat 2801581 gctttctaat ccagccacca tccgcagcgt tgttgatttt ccgcatcctg acggccccac 2801641 cagcaccaaa agctccttat cctttacatc taaatcaaag tccttcacgg ttaattgtga 2801701 gtgatatgat tttttgacgt gttcaaatgt taatgaagcc atcagaaaag tccccctatc 2801761 ttttgacccg ttatttcgtc actggaaaca acttggtctt tctgttattt ttagagtaat 2801821 cgattcccat ttttgctata tttctaaaat aaaaaatgta aatttgtatt ataacgtcat 2801881 aatacattat aatataaata ataggttaaa aggaggctac cctttgttaa acaacggaag 2801941 ttctacacct ttatacattc agctaaaaca aatcatcact gatgacatca aaaagggcgt 2802001 gtattcccca accgccaagc tgcctaccga aaacgagctt tgcaccaagt ataacgtcag 2802061 ccgcatcacc gtcaggaaag ccattctcga tttagtcgaa gaaggctatc tgatcaggca 2802121 gcagggaaag ggaacgttcg ttaaaagccc taaattaaaa cgagagctga tcgctgtaaa 2802181 cggctactcg gaatttatgg aatcaaccgg caaaaaaccg aagcatcatg tgctgtccca 2802241 tgacatcatt ccagcgtcaa aacccatcgc cgaaaagctt caaatccaac ccgagagccc 2802301 tgtggttgaa ttaaaacgga ttttatataa tgatgatcag cctctcacct ttgaagtgac 2802361 gcattatccg cttgatttgt ttcccggcat tgataccttt attgctgacg gcgtctccat 2802421 gcatgatatt ttgaaacagc aatacaaagt tgtacccacg cacaatacga agctattaaa 2802481 cgttgtatat gcccaacagg aggaaagcaa atacctggat tgtgatatcg gggatgcgct 2802541 gtttgaaatt gataaaacgg cttttacatc aaacgaccag ccaatctatt gctcattgtt 2802601 tttgatgcac acaaaccgtg tcacttttac catcaacagc ccctacacat aacaggcata 2802661 aaaaacgaga cactgcttat agtattctcg ttttttcact gcttcccccg tcctccaagc 2802721 gataaggata gccatagccg aaagctccgt acacaccgca agttttcgca gccgtttcag 2802781 cagcctggcg caaagcatac gttatatcct gcttcacgca aaaggcagtc aaaaagcctg 2802841 ctataaaaga atctcccgct ccaagtgtat ctattatatc agcttccaca atcggctgat 2802901 gatagactcg atcacccgca gacaggattg ctccttggcc ccctcgggtc atacaaacca 2802961 ttttggctcc gtacccatga gctgttttgg caagctcacc gcattccgac tcactcaaat 2803021 cgcttcctga aaaaaacgca tacgtcacat aaggacagac cctcctcaaa taatcatcct 2803081 cccgattggt tgaaaaatca aatgagaccg ggaccagccc gcacagctgc ggaagatcgt 2803141 tctcaagcct gctgtacacg ctcgtatgca gcagatcatg cccgctgata aaagatacat 2803201 ctttctcctg aaacgcgagg cgaagccggg actgaatgcc gcctttattt gatctgacaa 2803261 aaatgcggtc cccctgttca tcaagggtga caatcgccat cccgttttct ccgtgcgcct 2803321 ggcggatata atctgcattg acctgctcca gcttgagaac gttcaacaga tgcgccgcgg 2803381 cttcgtcatt gccgacgatt ccgatatagg aagactcatg cccgagccgc ttggcaagca 2803441 cagcaacgtt taaggcattt cctcccgggt aaaatgtttc ttgatcctgg tagtaatcta 2803501 caacattatc tccaaccgca atcaatttca tagcgcttcc tcctttatcc ttttacactg 2803561 ccgcttgcaa tcccgcggac aaaatatttc tgcatcaata aaaatagaat aataatcggc 2803621 gcggctgaaa tcgttaaccc cgccagcagg acgccccagt ctgtctgcag cgcgtctctg 2803681 aactgcatca gcccggctgg aatggtccgt aaattctcat catctatgaa aataatcgca 2803741 aacataaact cattccatgt atggtaagcc gtcaaaatgc cggatgtcac caaaatcggc 2803801 acgctcattg gtaagaaaat tctgaaaaat actccaaaac ttgtacaccc atccaaatag 2803861 gccgcctcct ccaattcttt tgaaatagaa agaaaataag agcggatcaa aatgatggtg 2803921 aatgggatcc gataagccgc atacggcaag attaacgccc aatacgtatt gtacaggccc 2803981 agcgactgaa taatagaata aagcggcaca agactgacct gcggcgtcag catcaatccg 2804041 ccaagacata gcaccaaaaa gaatcctttt cctttaaact caaaccggga aaggccatac 2804101 gctgcccatg cactgataaa gacagtgatc acacacgtca gcgccgtaac gatgacactg 2804161 ttcataaaat aagaagaaat cccctgattc caggcggaaa caaaattttc cggatgccac 2804221 gaagacggca gcgaccagct gtgctcaaaa atatcgtcag agtttttaaa ggcgctcatc 2804281 accatccaga gaagcggata ggcaatcgca atcagataaa gaaacagaaa aacccacaca 2804341 gacgtttctc cgatatacca ttttcgtcta ggcttatctt tcacctcaat gtgctggtca 2804401 ggcaccggct ccaatctgaa cgaatctgtc ttcttctgag gcagcatcag ttactcctcc 2804461 tttccggttt taaagaactt catttgcatg agcgataatg caagcgtaat gattaacacg 2804521 acagtggcaa tcgctgaggc gtagcccatc atatcctttg taaaggcgct tttatataaa 2804581 aacgtgctca agacttctga cgcttttccc ggcccgccgc ctgtcaaaat gtacggctca 2804641 ttaaagaccg taaaggctcc ggtcagcgtc atgaccaccg caacaaaaga catctctttc 2804701 gtctggggaa cagtaatatg aaaaaactgc tgaattttac ccgcgccgtc aagccgggcc 2804761 gcttcataca gttcatccgg tattttttga atcgacacga tgtacagcat cgcaatataa 2804821 ccgacagatt gccactggga cacaaaaatg acagaaagca tagctgtgct gtcatccccg 2804881 agccaggccc tcgtcagctg atcaagaccg atggcctgaa gcagctgatt caaaagccct 2804941 gtctccggat tgtaaataaa atcaaacaaa agcgcgatca ccgtcattga gatgacaacc 2805001 ggcaaaaaga aaacggtacg aaaaaacggc gaccattttc tgaccagctt atcctcaagc 2805061 accgccgcca aaatcaaacc gccaaatacc tggcatacaa ttgagatcac tgcataaagc 2805121 acattattgg taagtgcctg atagaagaca ggatcatgaa ataattcaac atagtttttt 2805181 aagccgataa acgttttttc cggagaaaat gagctccact gaaacaggct gaggaataca 2805241 ttctcaaaaa tcgggatata aacgaaaagt aaaaaaacga gagcgggcac caaaaacaaa 2805301 taggggatta ttttattctg attgaccaag ggtatctcat ctcctttata aaaagaaaag 2805361 gtgcgaagct tcaccttttc tttgatttat tcagctgacg ccctcacctg ctttgctgcc 2805421 ttttgaacgg ctttcatcac ctgctgcggt gtcatgtcgc cgccaagcat ttgctggacg 2805481 cccgttaggt acgcatctgc gacttcaaca tcgacatcca tatcaaacca tggaaccatt 2805541 gatttggcat caacaatatg ctgaacggct tcacgctgaa tggctgttgc attttcttca 2805601 gtagccgtac cttgcactgc actgtatttc ccgacatctt tcacgagctt ttcgcccatt 2805661 cttttcgacg tcaagaactg caaaaattcc atcgcttcct tcggatgttt tgttcttgag 2805721 gagatcatga atccttccgg cgctcccgtt aacgcttctg aagatccttt ctgcccgctg 2805781 atttcaggaa atgggaacat cccgagatta accggttcaa ccagcttgat ttccgctgtt 2805841 tccgcatata tcatcgccga ctttccgctc ttaaattgct gtctcacata ttcgtggtcg 2805901 acggagttta catgtttatt aaagtaaggc atcagctctt gaagcttttc aagtgctttt 2805961 acgtagcctt catcagtaaa ttcacccgtt ttggcgttat agtccttttc ccgtgttttt 2806021 tcatcgacca tccgctgatt aagcgtgccg atatagtgcg agattgtcca agtcgccttt 2806081 gttccaaagc tgatcggtgt gtagccatgt tctttcagct tttttgacac atcgattaat 2806141 tcatcccacg tcttcggggg atcaagattc agcttttgga aaatgtcttt attatagaag 2806201 aatgatttag cgtccatttg ccacggtacg ccatattgct tgttttcata agtaaatggt 2806261 gtaatttgcg attgaacgag ctgtgatgac caatcggtgt catttttgta gtaggacgag 2806321 agatcaagtg ctttattgcc tctgataaat ttaaaagcaa actcatcgct ccaagagaag 2806381 taaatgtcag gagggctggt ggttcccagc atgaccttaa ttttatcttt ataggagtca 2806441 tttaaaacgg cttcaatttg aatgtcgata tctgggtgat ctttttcaaa ttccttaaca 2806501 acctcttcaa aataactttt ttccggctcc tttggccatc tgtggaaaaa tttcaatgtc 2806561 acctttccgt ccgctgaact gctttggctc gaacagcctg cgatggtgag catactgaca 2806621 gctgcaatga tcaagaacaa caacattttc ttcaaagggt tggcctcctc tggacattag 2806681 actataatgt tatataacat tatagtctaa tgcataatgg ttcttcattt tcagatcaat 2806741 actcaacttt ccacatgtat cttctatgag ataaaggatg atttctctcc tctgccagct 2806801 cgtctgcata gcttctcagc acacgattga gaacgagcgg agcaagatag cctttaactg 2806861 aatcgtcaat tgcagtgaag tcgtaagatg cagcatcaag cacagtgagc tttttgccat 2806921 actttttcga gaaggtaagc gcccgctctt caagaggtct tgtttcatct aaaccgagca 2806981 ggatgataaa cggcacggat tcatcaataa tttcaaacgg tccgtgaaaa tattctccgg 2807041 catgaatggc gtgggaatga atccattgca tttccatgag aatgcagatg ctgtaggagt 2807101 aagcgacacc gtagtttgca ccgcttgcca tggtataaat aatgctttct ttttcatggg 2807161 cttttgcaaa ttgcttggcg ttgtcagctt cctgcttaag ggctttttca tatacagcct 2807221 gcaattgatc taagccttca attgcttgct caaatttcgt attgttttct aatacttgca 2807281 gggttccaaa aacgatttga tacaaaacgc catagtttgt attgatcgca agcgcctcat 2807341 caccccaatc gtactgggca acatattgcg cttcctgcgc taaaggagac tccggtttaa 2807401 acgtcatcgc aatcgtaagt gcgcccttgc cccttgcaaa cgcagcagct ttgactgtct 2807461 ccggggtatt tcccgaatgc gagcacaaaa taacaagaga cttttcacca agctgaacag 2807521 ggttgcgctg aataaattcg ttggcgctgt agagatcgga gtttattgat tttgactctc 2807581 tgtcaaacac atacttactc ggatacataa tggcagaaga ccctccgcat gcgacaaaga 2807641 atacatgatc aatggttttc cctttcaaat cctgcaagaa agcttgaacc tcacgattta 2807701 cttttgctgt ggcctgactc aaatccttca ctcctcgttt ttattatata acgttatata 2807761 acattatata ttgttatatt aaagtccgcg ggtaggattg tcaatattat tttctgaaat 2807821 ttctcaataa tttattcgga tgacagacaa agggtctata tgcgaaaaaa tgcccaaatc 2807881 aaaagccaga acttgactta agctctggct tcgctgttca atccgcagac tgacgtctta 2807941 tttaaaaaat accttgtcta tattgtactt cgagtgctgt gtattgatga tatatgtttc 2808001 gtaaatctct ctttccattg gatcatcaac tacacatacc tcaattttat aaacttcatc 2808061 tctgtgatgt ttgatcggtg aaacagtgtc ttcgaaatgc ttcttaattc tctgtcttaa 2808121 ctttctggct ttaccgacaa acagcagctc gtcatgaatg ttgtaaaaca taaaaatgcc 2808181 gcctttgtcc cttgggatct ggtgaaagtc gatgaatccg tgaatcggtt ttatcttcgg 2808241 ctcgttatca ttagctgact gctgtcgttc agtgatggtg acattcggtg cgggtatatc 2808301 aatttttatc aaaatcagtt cacgtcctct ttttcattaa agataaatgc taacacatac 2808361 agaaaagaaa agctagaaca gctttattat atttgtttgt catgctctta cttattatgc 2808421 aagtgctccg gctggatcat aaggactaag gtctaattct gtctgctttc cgagaactag 2808481 ctttgcgagc tctgcaccca aaaacggccc catcgtcagt ccagaagcac ccaaaccgtt 2808541 tgcagcgtac aggccttgaa cattcggcac ggcccctacg accggcagaa atcccggtgt 2808601 aaacggcctg aagcccactc ttgtttcaac agcagccgca tcagcaagac ccggtgcaac 2808661 ggctaacgct ttgctcaata cttcgtgctg gcctccggct gtcacacgaa gatcatcaag 2808721 accggcatcg ttttcgtgtg tggcgccggc tacaattctg ccgttatcaa acgacagaat 2808781 gtactgatca ctcggcggca ttacaaccgg ccacgatcct gtatctgcat ctgtcatttc 2808841 aaaatgcata atctgcgctt tttgaaatga cacttgaaaa tgaatgccaa gaggcttcaa 2808901 tatctcattg gcccatgctc ccgccgtcac aatgaccgcg tcagccgcaa actgctttgt 2808961 atctgtttgc acgccggtga ctgttccgtt ttcaaaaagc aaggacgcat ttcctttgat 2809021 gaccgttgcg ccgcgtttct ctgcagcgct taaaagcgac cggcacagcg ctcttccgtt 2809081 cacacgggcg gcaccgctga tatgaaccga ttcatagccg tcagctaaaa tcggaaacag 2809141 ctttttcgtt tcacttgcag acaagcgggt aatgtcgccg atttccggcg catcctcccg 2809201 tctcttatac gccctttcct ccattttatc gagtttagac gcgtcagtat gaatgctgat 2809261 ggcaccgaca cgtttgtatc ctgtatccga ttcaccgtct ttttccaatt gatggattaa 2809321 atccttatag taccgcgctc cccccttagc aagctggtac caatcctgat tacggcgctg 2809381 cgagagccaa ggacagacga tccccgccgc cgcatcagtc gcttgtcccg gctctttccg 2809441 atcaatgaca gtaacgcgag cgcctgtttt tgcgagatga taagccgtcg acgcgcccag 2809501 aatccctgcg ccgacgatga tgtacgattt catatgcaaa caccttttct attataatgt 2809561 ctattcattt taccaaatca aatgctttcc ttcgaccttt tgccctaatg tggaaaaacc 2809621 gcgaagttcg tccaatctct ttactctcct atcgaatatc ctgtcactat caatagagaa 2809681 aggatgatac catgagcgaa aatcgtcatg aaaatgaaga aaacagacgc gatgcggcag 2809741 tggcaaaagt ccaaaacagc ggtaatgcaa aagtcgtggt cagcgtgaac acagatcagg 2809801 atcaggcaca ggcgcagtca caagacggag aagactaatg aacgaaaaca tcattcctct 2809861 taacagacat actcaagaga tacccactac tgaatctgtt atcaaaaaca gcggcaactc 2809921 agaggtccat atcgacattc acattgatac aatgccaatt gcttttgcta tattatgctc 2809981 tgcattagcc gcaaagcaga tgacaaaaga ggaattcgat atggcttata ctcaattgcg 2810041 agagatgaac agagaaaata acagcagatc atctgtaaag caaattatca atcaagagac 2810101 agaagaagag taaaaaaccg cggcccctcg gccagcggtt tttcttctgc atacaaaaag 2810161 gacgcgactg aatcggttac ttctgtacaa tttgaataag gttaccgcat gtatcgtcga 2810221 agacagctat tgtgacttcg cccatttttg tcggttccgt cgtaaacgtc acgccttttt 2810281 cctttaatcg gttgtactct ttttgaatat ctgcaacgcc aaacattgtg gccgggaggc 2810341 cttcggagaa tatcttcttt tgatactcct tggcggcagg atgttcattc ggttcgagta 2810401 aaagctcggt tccgtcttga tcatctggag aaacaagcgt tatccacctg aatttcccca 2810461 tgggaacgtc ttcctttttt ataaacccaa gtttttctgt ataaaactcc agtgccatgt 2810521 cttgatcttg tacaaatata ctggtaacaa cgattttcat actgtttttc cctccttcga 2810581 tatgaatgaa gcatggtact atgctaacaa tctggctaca agcaaaacaa cccacacatt 2810641 tatcagaggc cctgttctga ttttataaaa ttattctatc catcctttca gcaaattttt 2810701 aagcggttcg ttgttgaata taagtactcg atattttccc tttcgttttg atgttacgag 2810761 tcctgcatcc tccagtacag aaaggtgttt agctatcgcc tgtcgcgtaa tagaaaggtc 2810821 gtactttgta ataagacgta tcgtaagttc atacaacgtc agctcgttgc gttcagataa 2810881 ttcgtctaat ataagccgcc gagtcgaatc gccgagtgct ttgaatatag cgtctttgtt 2810941 cccattcata tattgagtat aagcaaccca ttagttgcat gtcaagtata agcaactgta 2811001 tggttgcgtg atatagaaac tgaacctatc cggcgcaggt ctgaaatatt ctaatcgata 2811061 aggaattaaa accattaaaa taacagtgga tatgtctctg aaaaataaaa gaagacgaac 2811121 ttcaaaagtt cgtcttctac aatcaaattc ggcacgccgg ccattttaaa gttgataact 2811181 atctctaaac cccttgataa acaaaggagt tttcatcatt aaccgataga accttccatt 2811241 tcgaacttaa tcaaacggtt catttcaact gcgtattcca tcggaagctc ttttgtgaat 2811301 ggctcgataa agcccattac gatcatttca gttgcttctt cttcagaaat accgcggctc 2811361 atcaagtaga agagctgctc ttcagatact ttagacactt tcgcttcgtg ctccaatgaa 2811421 atgttatcat ttaagatttc attgtaagga attgtgtcag aagttgattt gttatccata 2811481 atgagcgtat cacactcgat gttagagcgg gcgccttccg ctttgcgtcc gaagtggacg 2811541 attccgcggt acgttacttt tccgccctgt tttgaaatcg attttgatac gattgtagat 2811601 gatgtgtttg gtgcaaggtg aatcattttc gcacctgcat cctgatgctg gcctttaccc 2811661 gcaagagcga tagaaagcgt cataccgcgc gcgccttcgc cttttaggat acaagccgga 2811721 tatttcattg tcagcttaga accgatgttg ccgtcgatcc attccattgt tgcgttttct 2811781 tcacagactg tacgctttgt tacaaggttg taaacgttgt tcgcccagtt ttggatcgtt 2811841 gtataacggc agtagccgcc ttttttcacg atgatctcaa cgaccgcact gtgaagtgag 2811901 tttgttgtgt aaacaggcgc agtacagcct tcaacataat gaacgcttgc ttcttcgtca 2811961 acaatgatca gtgtacgttc gaactgaccc atgttctcag agttgatacg gaagtaagct 2812021 tgtagcggtg tttcaacctt cacgccttta ggcacgtaga tgaaagaacc gccggaccaa 2812081 acagctgagt taagcgccgc aaacttgtta tcagtcggcg ggattacttt tgcccagtgc 2812141 tcacggaaaa tatcttcatt ctctttcagc gcgctgtcag tgtctttaaa gacgatgcct 2812201 tgtgcttcaa gatcttcttt catgttgtgg tatacaacct cagattcgta ctgagcagaa 2812261 acacccgcaa ggtatttttg ttcagcttca ggaataccga gcttgtcgaa tgtttgttta 2812321 atttcttcag gaacttcatc ccaagaacgc tctgaacgct cagacggttt tacgtagtac 2812381 gtaatttcgt caaagttcag tgagtttaaa tctccgcccc attgaggcat cggcatattg 2812441 tagaaatgct caagtgattt caagcggaag tcaagcatcc attgaggctc ttctttcatg 2812501 cgagaaattt cttctacgat ttcttttgtc aatccgcgct ctgaacggaa aatggaaacg 2812561 tccttgtcgt gaaaaccata cttgtattca ccaatatcag gcattttttt agccatccat 2812621 tttcactcca atccttttaa ttgccgcctt cttctttcgc gactcctttt tcaagtgctt 2812681 tccatgacag ggttgcacat ttgatacggg cagggaattt tgaaacgcct tgaagggctt 2812741 caatatcccc gagatctata gaatcatcat actctttccc ttgcatcata tccgagaaaa 2812801 tcttagacat ggaaagggca gtttcaatat ctttcccttt aatcgcctga gtcatcatcg 2812861 aagcggatgc cattgaaatg gaacagcctt ccccttcaaa cttcgcatct tccacgatgt 2812921 ctccgtcaag cttcattgtc agtctgatgc ggtcgccgca tgtcggattg ttcatatcca 2812981 cgacaatgct gtcatttaaa acccctttat ttcgcgggtt tttgtaatga tccataatca 2813041 cctgtctgta caatgtatct aagtttgcat taaaagacat ttgtaaaata ctcctttgtc 2813101 ttttgaagag cttccacaag cttatcaatc tcttcctctg tattatacag ataaaagctt 2813161 gctcttgcag tagcagttac atccagccat ttcatcagcg gctgcgcaca atggtggccg 2813221 gctctgactg cgattccctc cgcatcaagc acagtcgcca catcgtgcgg atgaacatca 2813281 tcaaggttaa atgtgacaag cccggcacgc tcttccggcc cgtaaaccgt tacgccgtca 2813341 agctggcgga agcgttcaag cgcataagct gcaagcttgt gctcatggcg ggaaatctca 2813401 tcaagaccga tttcttcgag aaaatcaatg gcggcaccga ggccgattgc tcctgcaata 2813461 atcggcgtac ccgcttcgaa tttccacgga agctctttcc aagttgattc ataaagcccg 2813521 acaaagtcga tcatttcacc gccgaattcg gcaggctcca tgttttccag cagggctttc 2813581 tttccgtaca gcacaccaac accggtaggt ccgcacattt tatgggaaga aagcgcaaag 2813641 aagtcgcaat cgagatcctg cacgtcaatt ttcatgtgag gcgtgctttg tgcaccgtcc 2813701 accacaatga cagccccatt gtcatgagcg attttcgcca tttctttaat cgggttgacc 2813761 gtgccgagaa cattagatac atgagacacc gcaacaattt ttgtgttgct tgtgaccgtt 2813821 tctctgacgt cttctaaaga aatcgttccg tcttcctgca acggaatata ttttaatgtg 2813881 gcgccagttg cttttacagc ctgctgccac ggaatgatat tcgcatgatg ctccatgtag 2813941 gtgatgacca cttcatcacc aggtttcagg ttggcgcgcg catagcttaa cgccaccata 2814001 ttcagtgatg tggtcgtgcc ttttgtgaaa ataatctcag ccattgactt cgcgttaata 2814061 aacttgcgga ctttttcacg cgctccttca taaccatctg tcgctctggt tccaagtgta 2814121 tggacgcccc ggtgaacatt ggaattgtat tggttataat acttatccag tgtttcaatg 2814181 acagcacgcg gcttctggga agtcgccgcg ctgtcgagat aaacgagatc atgtccgttc 2814241 acttgctgat gaaggatcgg gaactgttca cgaatatctg tgatattcat tacttcactt 2814301 tcctttcgat aacagaaact aattgtttct taacgccttc aatcggaagt tcatttacta 2814361 ccggtgcaag gaatccgtaa atgactaagc gttctgcttc ttctttcgga attccgcggc 2814421 tcatcaggta gtaaagctga atagggtcca cacggccgac agatgccgca tgtcctgcag 2814481 ttacatcgtc ttcgtcaatt aaaagaatag ggtttgcgtc tccgcgtgct ttttcgctaa 2814541 gcatcagcac gcgtgattct tgctccgcat tcgctttaga agcgccatgt tcgattttgc 2814601 cgattccgtt aaagatagaa gaagcggaat ccttcatcac accgtgcttc aagatatagc 2814661 cttcagaagc tttaccgaaa tggatgattt gtgttgtgaa gttttctgtt tgctctcctc 2814721 ttccgacaac aaccgttttc gtatcgccgt atgtgccgtc accgtaaagg tttgttgtgt 2814781 tttcggaaat cgtgtcgcca tcgttcatca ggccgagagc ccactcgatt ttgctgtcgc 2814841 gtccgcgcgc agcaccgcgg cggttcacat aagttgtcac accgcttgac agattatcca 2814901 ccgcaccgta tgtcacgctg gcattatcac ctgtgatgac ctcactgata atattgaaga 2814961 cagcgtcttt cgggtttaca gtgctgatgt agttttctac atatgttaca gagctgtggt 2815021 cttcagccac aatcagcacg tggttgaata gagctgtatc attgctttcg tggacataaa 2815081 cagcctgaac cggcgtctcc acctgaacat ttttcggaac ataaaggaat gctcctccgt 2815141 taacaagagc cgcgtgaagt gcagttaact tatgttcgtc aaccttcacg ccgtccttca 2815201 taaagtattt ctccaccaag tcgctgtgct cgcgtgcagc agtcagaata tcagtgaaga 2815261 tgacgccttt gtctttcaat tcttgagaaa gagaaagatg tgccggcgtc tggtcacgct 2815321 gtacgtataa tgttttatct tcgttttcaa tgtcgatcag cgcttttact tcatcagtca 2815381 aatcttctaa tgaagaaagc ggttcgttat ccactgtatg cttcgcgaaa ttcgtgaagt 2815441 tccagtttgt gatttttgtt ttgtcaggtt tcggcatcgg cagatcctca gcttgttcaa 2815501 gagcctgtaa gcgcaggttc ttcagccagg caggttcttg gtgcttttcg gaaaagcttt 2815561 tgagatactc ctgatctacg gatagttttg tacctagtgt catattaatc cccctaacgc 2815621 ttacgcttct tggccaacag tttcgtcttc aatgccaagt tcttgtttga tccagtcata 2815681 accttctgct tcaagacgct gtgcaagctc tgcaccgccg gattttacaa cgcggccttg 2815741 catcataacg tgaacaacat ccggagtgat gtagtttaac aggcgctgat agtgagtgat 2815801 catcaggcag ccgaagtttt cgctgcgcat tttgttgatc ccttttgata caactttcaa 2815861 agcgtcaata tcaaggcctg agtcaatttc atcaaggatg gcgattttcg gttcaatcat 2815921 cattaattga aggatttcgt tgcgtttttt ctccccgcct gagaagcctt cgttaagata 2815981 gcgctgagcc atttcagggt ccatttcaag gaactccatg ttttcgtcca ttttgcggat 2816041 gaatttcatg agagaaattt catcgccttc ttctctgcgc gcgttgattg ctgagcgaag 2816101 gaagtcggca tttgtcacac cgctgatttc acttgggtac tgcattgcaa ggaataagcc 2816161 tgcctgcgca cgctcgtcca cttccatctc cagtacatct ttgccgtcaa gcgtgatgct 2816221 gccttttgtt acttcatatt taggatgccc cataatagca gctgataaag tggatttacc 2816281 agttccgttc gggcccatta ctgcgtggaa ttctccacct tttatttcaa ggtttacacc 2816341 ctttaagatc tctttccctt cgatttcaac gtgaagatct ttgatcgtta atgttgaagc 2816401 agccatatct atacctccaa aaatatataa tcattattct cattttattc tcattctaat 2816461 tttataacaa atgaaaagta aatacaactt tttatcgtgc cttgcacatt cctcaagttt 2816521 aacaaagatc agcactttat taaagcgatt gaaaaagaaa aagagtggat tcccaccctt 2816581 ttttaaaaga ttgattttct caataagctc ccgcagaaat ccgcttgctt ttttcataat 2816641 caagctctct ctgccgctct actttcattc ttgtttccag ccggcgtcca tattcctcgt 2816701 atccaattcc gtgtgacagc tgcatcgctt tttccatttc tgacgtataa tcgaggttca 2816761 gtctgtcctg gctgctgcaa ataatgaatc aatcccttca tatatttgct ttttattgta 2816821 ccagtgctgc gttggatgcc gcaaaaacga tttggcgtga aatagcggca gatgagacga 2816881 aagcatcctt tcagaacaaa tgagaatggt ttttcggaat attccttctc ttaatgcgtg 2816941 gtgtttccga attcctcaat gcactgttga acgactgtca cgccttggct gaaagctgcg 2817001 ccgcctccaa atgccgctgc cacactgacg gcttcgagaa tgttttcttc tgacgctccc 2817061 tgatcaagac agccttttgt atgatagatc atgcaatatt cgtcctgagc attgatggca 2817121 attccgaggg cgatcagctg tttttctctt tcagtcagag aattcccggc aaagcactgt 2817181 tcagtaaatt cgttaaattt tcttcccatc agcggcatct tttgttcaaa tgtgcctaaa 2817241 ccatgtttat attgttttaa cgcgtcctgc atgcttcctc tgtcttgatt caaagaaaat 2817301 ccctccatct gtttaacatt cctttttatt atgaacagct tttaggaaaa tacgcgaaaa 2817361 aaaccccgga attctcatcc ggggtttcag tcttattcag atacaggaag cacagctccg 2817421 tcgtattttt tctcgatgaa gtctttgatc tttttagagt gaagaacttc catcagcgct 2817481 ttgatttttg cagaatcttc ttcgcctttt cttactgcga tgatgttagc gtatgggttg 2817541 tttttcgttg attctacttc aattgcgtct tttttaggat ttaatttatt ttggatcgca 2817601 tagtttacat tgatgaagac cgcgtctcct tctttgtttt catatgcttt tgccgttaat 2817661 tcaggcgcta cttttttgaa ttcaaggttt ttcgggtttt tcttaatgtc tttcaatgtt 2817721 gcgtcaactg tttccacttt agaatcaaga gtgattaatc cagcgttttc aagcattgca 2817781 agcatacggc cttgttcagc aacgttgttt gtcagaatga ttgtcgcacc gtctggaagg 2817841 tctttcagtg atttgtatgt tttagagtaa ataccgaatg gctctaagtg aacagcgccg 2817901 gcattcacaa gtttgtaatc tgtgttttct ttcatttctt gctcaaggta aggaatgtgc 2817961 tggaagtagt tcgcgtccac ttctttatca gctaaagctt tattgtacat tttgtaatca 2818021 ctaagcactt tcactttcag cgtatagcct ttttctttca gcaatggttc agcttctttt 2818081 aaaatttccg catgcggtgt ttttgttgcc gcaacgacaa tttctttctt gccggattca 2818141 gcgccgttat tcgaaccgca ggcagccata actcctgcaa atacaagcag taatgcaccc 2818201 aaaaatagct ttttcaatgt aaatcctccc ttatcgtttg tctataatat ttgttattag 2818261 atcaccgatg atttgaataa taaacacgat gattaaaata aacacagtag caacgaaggt 2818321 aacatcagcg ttattagact gatatccttc tacgtacgca aggtttccaa ggcctcctga 2818381 accaatggct ccggcaattg ccgttgaacc gattaaagcg atggctgtaa ccgtaatgcc 2818441 agaaataaga gcaggcattg attccggaat cagcactttg aaaataatcg tagacgtttt 2818501 cgcgcccatt gatttagctg cttcaatcac acctttatcc acctcacgca gcgcgatttc 2818561 aacaaggcgc gcgtaaaatg gtgccgagcc gattaccagc gccggcaatg cggcgtttgg 2818621 ccctaagatc gtgccgacta aaaatttcgt aaaacctaat agtaaaataa ttaaaataag 2818681 gaacggaatc gatctgaata tgttaacaac ggctgcaatc actgagttga ccgctttatt 2818741 ctgccagagg cttcctttgc tcgtcagaaa gagcagcaag ccgaggatga ccccgatgac 2818801 aaaagcaaac agtaaagaaa tcagcgtcat ataaagtgtt tcatatgtcg cgttccataa 2818861 ttcagttaaa tcaacgttcg ggaagtattt ttcaaacatt cgtgatcacc tctgctttca 2818921 cctgtttgtc attaatgaat cggatcacgt tttgcacttc ttcctcgtcc ccgtcaatgt 2818981 ggatgaacag tgaaccgtaa gccccatcct tcgtctgcga aattttccct tgcagaatat 2819041 tgacgctgac attgaagttt ctgatcatct ctgtaatcag aggctgttca gctgactcac 2819101 cgacaaatgt gagctgaacc atttttcctg atgctgtatc atcaagaagg tgctgaagcg 2819161 tctctttcgt ttcttccggc tctgtcacct gttgaacaaa tcgttttgtc atttgttcct 2819221 ttggattttt gaagacatcg agaacctcgc cttcttcgac caccttgccg ttttccatga 2819281 cggcgactct gttgcagatt ttgcgtatga catgcatttc gtgcgtaatc agcacaatcg 2819341 tcaaaccgag tctttcatta atatcggaca atagatccag aattgaatct gtcgtttgcg 2819401 gatctaatgc tgatgtcgct tcgtcacaaa gaagaacctt cggattgttt gcaagcgctc 2819461 tggcaattcc gacacgctgc ttctgaccgc cgctcagctg ggacggataa gatttttctt 2819521 ttccttctaa acctaccagt ttaatcagtt cattggcgcg cttgatccgc tcgctctttt 2819581 tcaccccggc aatttctaaa ggaaacatga tattatctct gacagtccgc gaccaaagca 2819641 aattgaaatg ctggaaaatc atactgatct catggcgtgc ttttcttaaa ccgcgtccat 2819701 ttacttcatt aatcttggtt cccgccactt ccacggttcc tgaggttggt ttctcaaggc 2819761 cgttcagcag acggattaag gaactcttac cagctccgct atatcctata attccaaaaa 2819821 tctcaccttt tttaatggaa agcgagacgt tttggacagc attgacatct ccatgtttcg 2819881 acttgtaaac ttttgaaaca tcctgaagat tgatcaaagc aatcacctgc cttaacacta 2819941 ttctaagaaa tcttccggtt ttttctgcaa aagaaaagcc tttctgcaca cttgagcaga 2820001 aaggcttata taaaatgcct ttctctcatc tttcaaagct gaacgcttcg tgtgaattgg 2820061 caccatttca acagtgttga tggttgccgg gcttcatagg gcacttccct ccacctctct 2820121 tgataagaga aatatatagt ctttttcgtc cggaaattct taatgtagaa tagcacggcg 2820181 aatgattaaa tgtcaataaa ataaatgatg tcaactttta ctattataat aatttattat 2820241 tttttaattt tttaaaatcc tctgaaaaaa tccatttgtc agccagagaa tggcttccag 2820301 ctttaacagg gccctgaatg acccctttac tttgaggctt ccgctctgaa taaggtgctg 2820361 aagggaaatg tctccgtgca ataaatcaat aatttccgtt tggtttccgt aaaaggtcag 2820421 gttggacgtt tggggcggag aaactttttt catttctccc tgttcgttta ttgagacggt 2820481 taaggcttct gcttctcctt ggaaggtaat gagcaatgtt gaggcattca aaaggggttt 2820541 taaaaacaga tgctgatact catcttctaa aacttccgct ttctccatat gtacaacctc 2820601 ctatttgttg gtcatacata cacatttctc tctttgtcgc aagaacccct ttataaaacg 2820661 aacgacaatt tcattggata tgctgagaaa tatgtcataa atgggatgcg gaagatgatt 2820721 tttgtttgat cagctcatat aaataagaaa cggaatgaaa tgcatatcct ctttcgacca 2820781 tctttccgcc tttaaacagc agaaaacaag ggacgctttc aatttgatac gcttttgcga 2820841 atgtcggaga gtaattgaca ttgttttgat agaaggcgac atccggcagc atttctttca 2820901 ccactgtcag cattttgctt gcaagctggc aggtgccgca aaacggagta tataaatata 2820961 gaaggtacac atcatcttca atgtgatcaa gttcgtgttc ttggagttct ttcatgctat 2821021 acacctcggg actttctttc aagaaaaata gtatggacat tcagattcgc acgcagcaat 2821081 acagaagcga tatggtgcct gggcgcagcc gctacttcct tataggctct gtcgacatgg 2821141 agatggcagg cttcattaaa ttcacgcttc agctgttttc tcaatttctc acctgattca 2821201 tcagcatcaa ctaatatata gacgtcttta tcataaagct cgtcagccaa ttcctcgagc 2821261 ctcagctggc tgattgttcc gtttgtgcag ataatgcgca tcggttcatt caggacgctt 2821321 tcgattttct ctttatctga tttcccctcg acaatcataa ccttttccag ctcatccatc 2821381 ttcatcttgt tcacctgccg cgtcaaattt gaaatgttca gattgtaaaa gaaggcagtg 2821441 aaattcaccg ccaacattaa caccagccgt tttcgtagtc acaatctaca tattttgcgt 2821501 cgtctccaga gaccacatcg gctgtcttat aaaatttctc attttcaaag gaataaccgg 2821561 acttaagctc atattcattc atgcttgtca tttggccgat catctcatta tcatgatata 2821621 acgagagccg gccattttga aagcggcctg tcacgtcatt ggtgacatcg agcttttgtt 2821681 tgtcgaaagc catattggac acctcccata acgttagcgt gtccaattgc ttttacggct 2821741 atcctgtttt agtcttcttg tgtcatctct tcgtattgct ctgctgtcat cagtttttca 2821801 atttcagaag cgtcagatgg ctcaacgacg atcatccatg ctttttcgta cggagattcg 2821861 ttgacgaatt ccggactgtc atcaagatct tcgtttactt ccacaaccgt tccgttaatc 2821921 ggtgcataaa gctcagatac cgttttaacg gattcaacac tgccgaatgg ctcgtccgct 2821981 ttgatttcag cgcccacttc aggaagttcg acaaacacga tgtcgcctag ttcggactgg 2822041 gcaaaatgcg taattccgat tctggctttt tctccttcaa cttttaccca ctcgtgttct 2822101 cctgagtaac gcaaatcttt tggtatgctc aattgaatcc ctccattttt tacagcacta 2822161 caataagaag ataccacact tttcaaaaaa aatttacatt aagcccagtt ttcttcaaat 2822221 tggtcttctt taaatccgac agtcactttt tcgccgtctg ttgtaagcgg gcgtttaatt 2822281 agcataccat ctgaagccag cagttcgagc tgttcgtcct ctgacatatg atacagcttt 2822341 tccttgagat tgagctcgcg gtatttcatg ccgctcgtgt tgaaaaattt cttgagatcc 2822401 agcccgcttt tttcataaag cgcttttaat tcttctttgc ttggcggctg ctcagcaata 2822461 tgtatttcgt ttatttcttt cccatgctct tcaagccact tctttgcttt gcggcacgtt 2822521 ccgcatttag ggtaccagta aaaagttaac gacatcttct tccccctcaa taaaataatc 2822581 gaggttattt taacacagtt tgttttaaaa acctaaaaca gtgcttctta aaaaagagct 2822641 ccgcgcatgc ggagctcatg gccaatcaga cagtatattt ctcagcctca aaaatgcctg 2822701 ccgccgcctc gcgttttttc tgaatcacgt ttttaggcgt tacgcgtgtc agcttgcgca 2822761 gagcggaaag catcatgcgg agtgaatctc cttcttccat tgcgataagg gattcctttg 2822821 catgcgcttc gatttcgtta aaggcctctt gaacgaaaat ttctgtgtac agcacctttt 2822881 gcgctgcttt ttcagcgcct tgtgcggcaa tggccttttc cgttctgagc acggctgatt 2822941 ccattgcgta tacattgctg acgatatccg ctacgttcac gagaatttct tgctcacgat 2823001 cgatcgcttt tccgtatttt tgcgcggcta ggccggcagc aaacaacgca atttttttgg 2823061 cttgcttgac gatatatttc tcctgctcta agacgccgct tccaggctct tcaggcataa 2823121 gcatcatgag ttcttcctgc agcgactgcg ctttttcgaa taaaggcagc tcgcctttaa 2823181 gcgctttttt caggaaggtg cttggcacga ttaaccggtt gatttcgttt gtgccttcaa 2823241 aaatccgatt gatccttgaa tccctatagg ccctttctac ttcgtattcc tgcataaagc 2823301 cgtagcctcc atgaatctgc acgccttcat caacgatata atcaagcgtt tcagagccga 2823361 ataccttatt cagagagcat tcgatggcgt attccgcaat cgatttggcg atttgccggc 2823421 cgtccttgag atcttcggcc gtgaactggc tcatattgtc ttcaaacagc ccgacggttc 2823481 tgtatacaga gctttccatc gcatacagcc ttgaggccat tgtcccgatt ttttcctgtg 2823541 tcaatgaaaa accagcaatc ggcgttttaa attggcggcg ctgatttgcg tatgccgcag 2823601 acagctcgat gacgcgttta gatgcgccga ttgtgccaac cgccagtttg taacggccga 2823661 tgtttaaaat attaaaggcg atgacatgcc ctttgccgat ttctccgagc aggttttcct 2823721 ttggcacttc agcttgatcc agaatgaggg ttcttgtcga tgatcccttg attcccattt 2823781 tcttttcttc cggtcccgtg gagacacccg ggaactcttt ttctacaata aaggctgaaa 2823841 acttgtcgcc gtctacctta gcgtaaacta caaatacatc ggcaaaagca gagttggtaa 2823901 tccactgttt ttcccctgtt aatacataat gggttcctgc ttcattcagc acagctgttg 2823961 tttttgctcc aagtgcatca gacccagagc caggctcagt cagagcataa gcggcgatct 2824021 tttcgcctga agcgagtcca ggcaaatatt ttttcttttg ttcttctgac ccgaaaaaga 2824081 cgatcggcaa ggaaccgata ccgacatgcg cgccataaga aagagaaaag cttcccgcac 2824141 gcgaaaattt ctcagtgatg agtgccgagc tgattttatc aaggccgagc ccgccgtatt 2824201 cttccggcac atcggcgcca agcagcccta gttcgcccgc tttcttcaac agtctgacag 2824261 aatgctcgaa ttgatggttt tcgatatcat ctatatgagg gagaacatct tgctcgatgt 2824321 aatcctctgt tgttttcgca atcattttat gctcgtcagt gaaatcctcc ggtgtataca 2824381 tttgatcgta tgtgacatcc tcgattaaaa atccgccgcc tttttgtacg tcagccgctt 2824441 tttttgccat ttgtttttcc ccctttagca taattcaaat acaccggccg ctcccattcc 2824501 gccgccgata cacatggtca cgactccaaa ttgctcgttt ctccgtttca tttcatggat 2824561 gagtgagagt gtaagctttg tgcccgtaca gccaagcggg tgtccaagcg cgattgcgcc 2824621 cccgttgaca ttcacttttt cttcatcaat tcccaattcc ctgattactt gaatggcctg 2824681 tgaggcaaaa gcttcattca gttcaaacaa gccgatgtcc tgcagctgaa gtccggcaag 2824741 cttcaaagcg cgcggaatcg cttccaccgg tccgattccc atcacttccg gcggcacgcc 2824801 gcctaccgca aaggagcgga atttcacaag cggcgccagg ccaagagcat cggctttttc 2824861 ccggtccatc agcatgacag ccgccgctcc gtcactcgtt tgtgaggaat tgcccgcagt 2824921 caccgtcccg tcaacggaaa aggccgggcg caatgtcgat aagatgtctg cagtcgtttg 2824981 cgggcgaaca ccttcatcct gagaaaacac aaactgtttt tccataggct tatggtcttc 2825041 tccgatttct gtcaccgtca cttcgacggg tacaatttca tctttaaatt ttccttctgc 2825101 aagggcttta gcggcgtttt gatggctgcg aacggcaaac gcgtcttgat cctcacggga 2825161 gacgccgtat tttttcgcga cttgctcggc tgtgtgcccc atgctcatat aatattccgg 2825221 tgccttttct gccaaagcaa ggttcggacg ggtaacatgc cccatcatcg gaacttgcga 2825281 catggattct gctccgccgg cgatcgctgt atcgtaggcg cccagcataa ttttttctgc 2825341 tgcatacgca atagactgaa ggcctgaaga gcaatagcgg ttaactgtaa tcgccggaac 2825401 cgtgtacggc aggcccgcga gcgcaccgat atttctcgcc atattaagcc cctgctccgc 2825461 ttcaggtgtt gcacagccga taatcaagtc atcaatattg ccttcgtagc cgcctgcccg 2825521 tttcagcgtt tcttttacac aaatcgctcc caaatcatcc gggcgaacgg tggccaacga 2825581 tccttttttt gcttttccaa ccggtgttct tgcacctgac acaatgactg cctctttcat 2825641 aagctccctc ctaattccgt aaaggtttac ctttcacaag catatgctgc attctcgctt 2825701 gagattttgc ctctcctgac aaactcaaaa acgcttctct ttcgatctcc aataaatact 2825761 cttcatcaac ctctgtacca aacggcactt ttccgcccgc aatgacataa gcgagttttt 2825821 tcgcgatctt aaaatcatgc tcagatatat agccggacag cttcatctgc tcagcgccaa 2825881 gcaagagtgc cgcataaccg gtttctcccg gcaccttgac cttttctttt acaggcggcc 2825941 gccagccggt atcgtataaa gatgcggcca gctgcttcgc atcgtataac aggtggtctt 2826001 gattcacgct gatctgatcc gtttctttta agatgttcat ctcacgagcc tcttgagcgg 2826061 aagcggacac tttcgccatc gcgattgttt caaatgtttt cattgccgca ttcatcggat 2826121 catggccgcg gcgaagatgg ttgatgtaca gctctttgtt acctcctccg ccagggatga 2826181 ggccgacacc ggattccaca agtcccatat aggcttcgct tgccgcttga atgcgcgccg 2826241 ccggcaggca tgcttccgtt cctccgccga gcgtcatgcc aaatggcgcg gcgacgaccg 2826301 gtttcgcact gtatttgatc ttcatcatcg tctcctgaaa acggcggatc acaaaatcaa 2826361 cttccaaaaa gttgtcatct tggacttcca ttaagatcat ggcgagattc gcgccgacgc 2826421 agaaattttt cccttgattg ccgatgacaa gccccttgta attccgttct gtttcctcta 2826481 atcctttgtg gatcatttga atgatatcga ggccgatcgc attgcttttc gaatgaaatt 2826541 caagaagggc cacatcatct ccaaggtcaa ttaagcttgc tccgctgttt ttcgcaatca 2826601 cgccttttgt ttctttaagt gcttgtaaat gaattcgttt tttgttttct ttcacggctc 2826661 tgtattcgcc gcggtcataa taaaataccg ttccgttctc tttgatgtag aaggtttcat 2826721 ttcctttgtc cagcatctct tttatccagc caggcatatc tgctccaagc tgctcaagct 2826781 tttccgctga ctgcttgagg ccgatggcgt cccacatctc aaaaggtccc agttcccagc 2826841 cgaatcccca cttcatggct tggtcaatcg catgaatatc atcggcaatc tcgccaagca 2826901 gctcggctga gtaaagcagg gtttgagaag tgatattcca cagcaaacgg ccggccctgt 2826961 catccgaata aataagcgct ttcattttgg cttttgtccc ttttgcctgt tttgccgctt 2827021 caagtgccgg tgatttcatt tttgtccgct cgccgtaagt aagcgtcact gggtcaagct 2827081 cataaatcgt ttttccttct tttttataaa agccttggcc ggccttgctt ccgatccacc 2827141 ctttttccag catatcgttc atgaagcttg gaatgcgaaa cacttctttt tcatcgccat 2827201 cagctttgtc atacacattt cgggcaacgt gggcgaatgt atcgaggccg accacatcaa 2827261 gcgttctaaa ggtggcgctt ttcggcctgc cgatcagcgg tcctgtgatc gaatcaacct 2827321 ccccgacctg ataaccgcct ttcagcattt cttggactgt cacgagaagc ccgtaagtcc 2827381 cgatgcggtt tgcgataaag ttcggtgtgt cctttgctgt aacaacgcct ttcccgagga 2827441 cattttctcc gaaagctgtc ataaacttta aaatatcagg atccgtttcc ttaatcggaa 2827501 tgatctctag cagctttaaa tatcgtgcgg gattaaaaaa atgcgttcca agaaaatggg 2827561 ctttaaaatc atccgaccgg ccttcagcca tttcctgcac tgatatgccg gatgtgttgc 2827621 ttgagacgat gcttccagtc tttcgatgtt catccacaag agcgaaaatt ttctttttga 2827681 cttcaaggtt ttcgacaacg acctcaataa tccaatctgc ttctttcagt ttttctgcat 2827741 catcctccag attgccaggt gtaatatagg aggtattttt cgctgatgtg aggggagcgg 2827801 gcttttgttt cagcagtttt ttcatcgcct gccggctcag cctgctgcgc acctccgaac 2827861 tgtccttcgt cagccccttt ttttcctctt cctttgtcaa atcgttcggc acaatatcta 2827921 gcagcaggac aggaattccg atgttagcca aatgcgccgc tatcccggaa cccattaccc 2827981 ccgatcctaa aacggctgcc ttccgaatgt gtttgtgcat gagatatccc ccttgaacat 2828041 tgaatgaata gtcattcatt ttttgactaa aaaaaatgaa acccgtttct tctttcatct 2828101 taaaagattt ccggttcgac ttcaatagct aatttgttat ttttttgtat gaagcctata 2828161 aaagtcgggc aacttaagcc cggaggtgaa gggaatggta cgagagaaaa aaaatccgtc 2828221 ttcagcggca gtcagcgcgg cgagcgtaaa gggagatgcc ggtccgactc agcattacgg 2828281 cggcggaaaa cggacaagtc aaaatcagca gtataaaaaa cataacatgg gacaatcata 2828341 atgcagctgc ttcccacggc tgctttcact ttttcaaaat tccttttaac acaaacgctg 2828401 cattggcagg ccgttcggca attcttctca taaagtagct gaaccagtcc gttccatatg 2828461 ggacatacac acgcattctg tagccttcct tggcgagttc cttctgacgc tccggcctga 2828521 tgccgtatag catttgaaac tcaaattgcg atgcggggat ttgatgttcg gcgacgagct 2828581 gtttcgtaaa tgcaatgatg tcatcgtcat gtgtggcgac agccgtgtag ttcccgctta 2828641 acaactgcag ctttattaag ctctgaaaat gaaggtccgt gcctcttttg tcgggaaacg 2828701 ctacagccgc agattcttta taagcgcctt ttacaagtct gagattcggc tttaagtccc 2828761 gcatctttct gatatcttct gccgcccggt acaaatacgc ctgaatgacc gtgccgagct 2828821 tctcaaattc ctgtttgcat tgcctgtaaa tagaaagtgt ctgttcataa tgagaatagt 2828881 cttccatatc aatggtcaca gcaacatcat attgcttcgc aacggaaaga atggcgcgca 2828941 aatgagtaag agcaagttct tctgaaagat cgagcccgat tgaggtcagc ttaagtgaaa 2829001 gctctgaatt caattgatgt tcggcaatgg cttgaatggc tttcttgcat tcctctgcga 2829061 cttggtttgc ttctttttcc gaagctgcat actcgcctaa ataatcaatt gttgcacaca 2829121 aaccggatct gtttagcctt ttgacggtct taaccgccga ttcaatcgta tcccctgcga 2829181 caaaccttcg tgctccaagc cgcgttccgt atgcttttgc gaacttggta agtgttttat 2829241 tttgagataa gaataaaaac acatgtctca acatccgact ccctcccgcc gtcatcttca 2829301 aaacacctgt atataactcc cagtctgaag gaaactataa aatgaacaga aaccaaagga 2829361 ggatcacaat ggataatcag cagcaatctc aaatgccgcc ttccgttatt tcgacaaagg 2829421 atcatttgta tctcaatgac atgctgaact ggaatttgct cgcgatgaaa aaagcgcatt 2829481 tcatggcgca gcagtgccag gatcaaacgt taaagcaaga actcgaccgc gtcggacaca 2829541 tgcatcatga tcactatcaa agaatattaa agcacctgca gccaggccag cagcagtccg 2829601 gctacatcca ataaggaggc gccagaatga atcagcaaaa tcaaaaaatc agcaacccgc 2829661 agacacctgt accgacaaca tcggaaatga atgacagaga tttcgtcaac gaattgctga 2829721 caaccgaaaa atacatgaca acagcttatt gcactgcctt gcacgaattc agccacgagt 2829781 ctctttatca ggatattcaa tccatttttg atgagtcaca aaaagcgcaa agaaaactat 2829841 atgatctcat gttccaatat ggatggtatt ctgttgaagc ggaggattca caaaagctgc 2829901 agcagtccta tcaaaaattc cagcagacca ttcagcagca gtctccttat cagcaataac 2829961 aacattagta aaaaggatac gatgttcttt cgggcatcta tccttttttt gtgtaaaatc 2830021 agttgacttt tcatttacgc ttatttatat ttaataagca ttaactattt tgtcattaaa 2830081 atatatatac agtgtatgta acagagggga aatgaatatg aagagtgcgg atcagttaat 2830141 gtccgatatt caattatcgc ttcaggcgct ctttcaaaag atacagcctg aaatgctgga 2830201 aagcatggag aaacaaggtg tcaccccagc gcagctgttt gtgctggcca gcctaaagaa 2830261 acacggcagc ctcaaagttt ctgaaattgc cgagcgtatg gaggtgaagc caagcgcggt 2830321 gacgctgatg gcagatcgcc ttgaacaaaa aaatcttatc gccagaacac acaacacaaa 2830381 agacaggcga gtgattgatc tcagtcttac tgacgaagga gacataaagt tcgaggaggt 2830441 tttggcgggc agaaaagcca taatggcgcg ctatctttcc tttttgacgg aggaggaaat 2830501 gctgcaggcg gcgcatatta cagcaaaact cgcacaagca gcagaaacgg atgaaaagca 2830561 aaacatgaaa agaggaaacg gatgaaaatg agtaaagaag gcaaacaatc aaaacgaacg 2830621 ttattaataa caggcttaat tattgccatg tttttttcag cccttgacgg taccattgtc 2830681 ggaacggcca tgccgaaaat tgtcggtgat ctgggcggtt tgagcatgat gacctggctg 2830741 acaactgcat atttgttaac atcaacaacc attgttccaa ttgccggtaa actggctgat 2830801 ttattgggac gccgcattgt ctatgtatca ggtttgatta tttttatggc cgcttctgct 2830861 ttgtgcggaa tggccaacaa catgacggaa ttgattatct tccgtggact gcagggcatc 2830921 ggcggaggca tcatgatgcc gatggcgatg attgtcatcg gtgacttgtt cacaggaaaa 2830981 cagcgtgcta aattccaagg tgtctttggc gcaatttacg ggctggcttc agtgattggg 2831041 ccgcaaatcg gcggctggat tgtagactcg ttaaactgga aatgggtttt ctatattaac 2831101 ctgccagtcg gaattattgc ggttattttt attgccaggg gattacaggg acgccagcag 2831161 actggtccga tcaacttcga tatcgctggt attttcacaa tgattgtcgg tgtggtcagc 2831221 ctcctgctcg ccttaagctt tggcggaaaa gattatgcat gggattcatg gcagattctt 2831281 gggttgttcg ctctcgcact gatcggcatt gtcagcttta tcatcgtaga atcaaaagca 2831341 aaagagccaa tcctgccaat gtatttattt aaaaacagaa catttacatt tctaaacttg 2831401 atcggcttct ttatgagtat cggtatgttt ggcgccatta cgtttgttcc tttctttatg 2831461 cagggaattg tcggtgtaag tgcgtctgaa tcgggtacaa ttatgacacc gatgatgatt 2831521 tctatgatta tcacaagtat catcggcgga cagcttgttt ataaaattgg gattaaaccg 2831581 caaatcatta caggcatgct ggttatggcc ggcggattcc tgctgttaac gacattggat 2831641 ctcgacacga gcaagcttgt cgctacatct tttatggcga ttattggtct gggaatgggt 2831701 cttgttatgc cgattctgac attggcttta caggaaagct tttcgaagga ggagcttgga 2831761 gttgtcactt catccagcca attcttccgt tctatcggcg gaacattcgg cattaccatg 2831821 ctgggagccg taatgaatgc gagatcagga aatctattaa cagataaatt ggttccatat 2831881 ttagactctc ttccggcaca ggcaagctcg tttgccgccc agctaaaggg tatgattgat 2831941 acaaatccgc aagggctgct gcaatcactg ttcagtccgg acgcggtcaa acaaatccct 2832001 gcggctttct catcccatat tgtgccgatt ttaaaaacat cgttgatgga ttcgctccac 2832061 agcgtgtttt atacgggcct gatctttatc gcagtcggag ccgtattcac cttgttctta 2832121 aaacctatca agctatcaaa taagaaagcg gaagaccaac aagaaaaaga gaaggcggca 2832181 aaagccgttg aatcaccttc ccattaatag agcaccccgc gggtatcaat ccgcggggtt 2832241 ttttattcaa tcatctgggc tcttccattt ccgaaagacc aatcctcatc ctgatttccg 2832301 gccagcatga taaacacatc ttcttttctt acaccaagct cggaatgaat ccggctcgcg 2832361 attgagcggt aaagtgcttt tttctgttca gttgttcttg actgtttcag tgtaaaatga 2832421 atgtatatca gttcatcagt acgctcgact tggagataaa atggatcata aaaaaattcg 2832481 cttttttcat attgtctgat gacttggaaa tagtcatctt ccggcacatt gatttcttca 2832541 atcatcgatt ggtggatagt cctgctcagt ttttgaagcc acacttcgct tcttcccgac 2832601 cgtaaatgaa tctgtacaaa tggcatctcc ccgcatccct ttctttacag cgtctgtccg 2832661 ctgtcaattg tgataatttg gcctgtgagt gattcctgtt caattagtga acaaatcaat 2832721 ttggcaacat catctggttc agcaatacac tgcagcagca aagagccgat catgcttttc 2832781 attttttctt cccgtccggc ccaccatctc gttgccacag ctcctggtgc tacaccgctc 2832841 actctgattt caggcgctaa ggcgtgggcc aatgatttcg ttaaaccgtg caccgctgat 2832901 tttgatactg cgtaaggcat tgatgagccg gcaccagtta tccctgcgat gctgccgacg 2832961 tttacgatcg ccccgtcctt gcttttcttc atgaacggaa ccactgcccg cgcgcagaaa 2833021 aacatccctt tcacattgac ggcatacagc tcatcctaga cgtcttctgt cgcagcctca 2833081 agatcatcca ttggaatatg ccgtgtaatg ctggcattgt tgactaaaat atcaaccgtg 2833141 ccgtgtgtgt tcacgattgc ttgaatcata tcctgcacgt cgctgttttt ggatacatct 2833201 gcttggatgg cgaaggcttg cccgccagct ttttgaatca tttccactgt ttcctccgct 2833261 tctgattgcg agcgtgaata attcaccgcc acaatcgccc cacgctttgc caattccata 2833321 ctggctgctt ttccgattcc tgtgccgccc cccgttacga gagctatttt gttcaagaca 2833381 ttcattgccg ccactccttg ctgttgacta aagtatattt ctgattccat tgtaatccag 2833441 ctttgatgtt acgtataatg attgttaaag atactagata tcactcagat tgatagtaaa 2833501 cgaacggagg agttcaaaat ggaaagcgga gatttacgtg tgtttcaaat ggtagctcgt 2833561 gaagggacca ttacgaaagc agccctgcag cttggctatg tacaatcgaa tgtcacggcc 2833621 agaattcaac aattggaagc tgagctgggt accacactgt ttttgcgcca taatcggggc 2833681 atgacacttt ctgcaagcgg aaaattgctg ctggactacg caaataaaat tataggcctt 2833741 cttgatgaag cgtctaaagc gctctcatcc tccgcagaac caagcgggcc gcttatgatc 2833801 ggctgcactc agacaaccgc cgcggtaagg cttccaaagc ttctggcatc ttattatgaa 2833861 gaacatccaa acgtccagct gtctttaaca acaggacata cgcaatttct ccttgataaa 2833921 gttcttcgtt atgaattgga tggcgcgttt atcggatgcg aatgccatca tcctgagctc 2833981 gaatcctatc ctgcgtttga ggaagaacca gtagttgttt cggctgcctc cgtgcccgat 2834041 gttgaggaag ccatcacaaa gccgattctc gtttacagca caggctgttc gtatcgagaa 2834101 acacttgaaa aatggctgcg ttccgtcggt gtcacacagc cggtcattat ggaatttggg 2834161 acgcttgaag caattatcgg cggggttaca gcaggtcttg gcatctcgtt gctgccaaga 2834221 acggttgtgc agaaacatga agcagaagga tcaattcgat tgtacccgct gcctgaagct 2834281 ctcagccaga tgaaaacaga gtttattgtt cgaaaagatt cgtttatcag cagcgcgctg 2834341 agaaccttta tggattcctt tacgccagtt aaaacggctg aatcacaaaa aagcagtctg 2834401 ctataatgaa cagactgctt tttggctatt gtttgtttcg atgcgcttca tttaattcct 2834461 taatatgctg aatgatctct ttaatgccct gcttcgcgtc ggggtatgtc gcattccaat 2834521 gcttagcgag cggaggcatg cttttggcta tatgggtgta caaaatccat tgcttcactt 2834581 cttcttttag ctcatcgttt gtttcaccaa gcagaagctc agtatacttc tccagcaatc 2834641 catcaagctg ctcctgaagt ttttgttcca ttttccatct tcctttcgaa aaaacagcaa 2834701 ggagctttct caattgaaag ctccttcgct gcgttattta tccatgtgat gtgaaagccg 2834761 cttcctggac aatgcatctg cccctgccat gaggaatgca aagaggcgtt ccgaagagcg 2834821 ggtcctgtgt aacctgacag ttcatagaaa acacattttg cacaagatca caagtgatga 2834881 cctcttccgg acggccttct gcataaatcc gtttatcttt tatggccaca agatgatgcg 2834941 catagcggca cgccaagttt aagtcatgga gaaccataac aatcgtccgg tcttcctttt 2835001 cattcagctc aaacagcaaa tcaagaattt caatttgatg cgtcatgtct aaatacgtcg 2835061 tcggctcgtc aagaaggatg atatccgttt cctgggcaag cgtcatcgcg atccaagccc 2835121 gctggcgctg tccgcctgac aaagaatcaa cggcacggtc agccatgtcc tcaagctttg 2835181 ttgctttaag cgctctttca actgcttcct catcctcttt tgaccactgc ttcagccagt 2835241 tttggtaagg atatcttcct tgcttcacca gctgatgcac cgtcagcccc tctggagccg 2835301 aaggaccttg gggcaggatt gcgagctctt ttgcgacttc cttcgtcgga agcttggcaa 2835361 tcgctcttcc ttccagcagc actgaaccgc ctctcggctt catcaggcgc gctaatgaac 2835421 gtaaaagtgt cgattttccg cagccattgc tgccaataaa tacggtaatt tcacctttgg 2835481 gaattgttaa attcaactca tcaataataa cggcatcccc gtatcctaag ctcagcgttt 2835541 ctgtagaaat tgcactcata cccataaccg ctcctttttg ctggcttttt agcagcacta 2835601 tgtattgcac gttttctata tacatgcttt taagtcaatt gtcatcaatg caaatgattc 2835661 cgatattcag ccatttgata tggtcatata tccctcattg tagcagaaaa cactgacttt 2835721 gaaaatcatt ttcaattagt tttatggaca taattgacgt ttatgggttt tttatcacaa 2835781 gattacttct tgatttctct gatggagccg tccttcagct tcaattttaa atcgatatga 2835841 tcataatgac tgtccagatt aaatgctgcc agcacactgt gtatcacttc tgtttcagcc 2835901 atttggtctg tcacggaaag ctcgctcaaa atcattttca tctcatctaa cgcttcttct 2835961 ccttcctgat tgacaccgga gagcttatcc tgtatttccg ctttttcctg agtcccgttc 2836021 tttgtataga ttccttcata acggttatgc tcaccatccc cgtagctcac acgaagcgaa 2836081 aaattactgt agggaacgga cttcagctgg gtgacggctg tattttctcc ttctgcctga 2836141 tgctggtctt cattgaaacg gcagcccgca atcagaacca ctgcgagaca tacagccccg 2836201 gctgctctga tcaaatgcat atgtttcccc cctgtaggat tccatttatt ttaggtatat 2836261 ccagagaatg aaatcctcat tcagagaaga attgaaaaag ccggggcatt taacgccacg 2836321 gctttttctt taagattcgg tcatttgtaa aaaggtttcg gcgtcacgca cagccagctt 2836381 gatggcattc tcccagaaat cgcgctttgt gatgtcagcg cccaaatgct tcatcgccaa 2836441 atcctccact gtcatagaag ccgtatcgcg caatagcgcc atatacttct cttcgaatgt 2836501 gtctttttct tcaagcgcca acgcgtaaat accaagagaa aacaggtagc cgaatgtata 2836561 agggaaattg taaaacggca ccctcgtgat gtgaaaatga agctttgatg cccaaaaaag 2836621 cggatgatat tcttctaacg cattgcagta tgcctctctt tgcgcctctt ccatcagctc 2836681 attcaagcgg ctggccggta ccactccccg ctttcgttcc tcgtagaatc tcgtttcaaa 2836741 tagaaatctt gcgtgaatgt tcatgaagaa cgcaacgctt ctttgcactt tatcctccag 2836801 aagaacaagc ttttcttccc tcgtctcggc ctgctggaca gtcgcgtccg ccactatcat 2836861 ctctgcaaac gttgaagctg tttctgcaac gttcatggcg taggaacggt ttaacggcct 2836921 gacgttgagc attgcttcct gatggaacgc gtgcccgagt tcatgcgcaa gggtagagac 2836981 atttgaggcg cttcccgaaa atgtcatgaa aatccgggat tccccgctgt ccggaaaact 2837041 ggtgcaaaag ccgccgactc tttttccgct cctgtcttcc gcctcaatcc agccgtcccg 2837101 aaacgctttt tcagtgaatg aggacagctt tttgccaaac gttgaaaact ggctggtaat 2837161 gatatttgcg gcttcatcat acgaatagac ctttccgtca gaaccgatcg gtgcctcgac 2837221 atcgtaccag ctgagttttt caaggccgag catggatgct ttccggttca aaaactgaac 2837281 gaacggcttc ttgttttcag tgatgacctg ccacatcgta tcaagtgttt cttttttcat 2837341 cctgttaatt tgcagcggtt ccttcaggac attctcccag ccgcgcgctt tataggtttc 2837401 aagccggaat cccgccaaat gattcagcgt gctgctgaaa atatcttgct tgctctccca 2837461 agcttggcgg aaacgttcat atactgtttt tctgacagta cggtcttgat gatccatcat 2837521 attctccgcc tgaccgacag acaattgctt gttttcaccg ttttcctcat acgggatcgt 2837581 cattttcccg acaaccatat tgtataagtc actccaagcg tgatatccgt ccaccgcaag 2837641 gtttccgatc agtttttcct taccggggct aagcttttcg gcaaccctct gtcttctttc 2837701 atttaatatg taagaaacat cgcgcaatcc cggttttgtt aacaattcat tccacacgtc 2837761 ttgattaatg tccacaagtt tatgatctaa tgtaacgagc gacgattgaa aatctgcgga 2837821 aagccgattc atgaggcctg atgctctata gccttttgat cattgatatt ctgggcctgg 2837881 aggcaagcaa caaaagcgcc ggcctgctga agcttgacgg atgtctgttc gaataaatca 2837941 agcaacgcgg tcagcccttc agcctcttca ggcgattcag gcacctgaaa cgcatcagtc 2838001 ctgtcttgaa atgcacgcag actttgtgac agcttctcaa tataaccttt gaattcttcc 2838061 gattggctcc cgcccttaaa aaatgaatca agatcccatc tttggcctac cccttgcagc 2838121 gccatatcac aaaacccctt tccttctttc gttctattat agaacaattc tgaattattg 2838181 tataaaaatt tctattacag gcgtcatttc gtgttcagga tagtacaata gctgtagcag 2838241 tttaatagga gggttaggat gaataaaaaa atagccatcg tgacaggagc gtccagcggc 2838301 ttcggtctgc tggcagctgt aaagcttgcc cgatcatttt tcgtgatagc cacatcaaga 2838361 cagcctgaaa aagcggaaca gcttcgagaa ttggctgcag cacacaatgt gtctgattct 2838421 attcacatta cagctctcga tgtcaccgat gaacaatcta tagtctcatt cggaaaagct 2838481 gttagtgctt acgccccgat cgatttactc gttaacaacg ccggaacggc ttatggagga 2838541 tttatcgagg atgtgccgat ggaacatttc agacaacaat ttgaaacgaa tgtcttcggt 2838601 gtgatccatg tgacaaaaac cgtgctgcct tacataagaa agcatggcgg cgcaaagatt 2838661 ataaacgtga gcagcatcag cggactgaca ggattcccag cgctgtcgcc atatgtttct 2838721 tccaagcatg cattggaagg tttttctgaa agcctgcgta tcgagctgct tccgttcggt 2838781 atcgaaaccg ctttgatcga gccgggctca tacaagacat cgatctggtc aacgtcatta 2838841 tcaaatttta tgtcggtgcc tgctgacgat tcagcctatc atcaatacta taaaaagatc 2838901 ctttcctatg ttcaaaaaaa cggagaagaa agcggagatc cccaagaggt tgccgacctc 2838961 atttatcaat tggcaacaaa acagcacata aagaatttgc gatacccgat cggaaagggc 2839021 atcaagctca ccctgctgtt ccgatcgctt tttccttggt ctgcgtggga gtctatcctg 2839081 aagaaaaagc tattcagctg atctaaatta taattattat aatttagtat tgatttttat 2839141 ttagtatatg atataattaa gtcaacagat cacaaggagg acgttatctt atgaaaactg 2839201 aaaacgcaaa aacaaatcaa acattagttg agaattcact gaacacacaa ttatcaaact 2839261 ggtttctttt atactctaag ctccaccgtt tccattggta tgtgaaaggg cctcatttct 2839321 ttacattgca cgagaaattt gaagaacttt atgaccatgc ggctgaaaca gtggatacca 2839381 tcgctgagcg cctgctggcg attggcggac agcctgttgc cacagtgaaa gaatacactg 2839441 agcatgcatc tatcacagac ggcggaaacg aaacatcagc atcagaaatg gtacaagcat 2839501 tggtaaacga ctacaaacaa atcagcagcg aatctaaatt cgtgatcggc ctggctgaag 2839561 aaaatcaaga caatgcgaca gcggacttgt ttgtcggatt aattgaagaa gttgaaaaac 2839621 aagtgtggat gctttcctct tatttagggt aacaaaaaag ctgaacctta atcgggttca 2839681 gctttttgtt ttttcttagc ttgaactgct ttctgtctgc ttggtcagtg ttgcgttcaa 2839741 cgttttcgtt tttccctttc gcagcacttg gattgttgtt ttatctccga cttttaagtc 2839801 tttgtaaagg atctgacgga tatccgcact gctttccacg tctttaccgt ttagtttgac 2839861 aatgacatcc tcagatttaa tacctgcttt ttctgccggc gaatttgctt gaacttcttt 2839921 tacataaaca cctttgccca attgatctcc aaacaggccg agcgtatttt cctgataggt 2839981 ttcaggaact tgtgacatgt caatcatctg cacgcctaaa aacggacggt ccaccttccc 2840041 gttttgcagc agctggtcaa caatcggctc gacatcattg cttgggatcg caaatccaag 2840101 tgattccacg ccgctttcgc tcaccttcaa gctgttgatg ccgatgacct ggccgcttgc 2840161 attgattaat gggcctccgc tgttccccgg attgatcgct gcatcggttt gcagcacgtt 2840221 catttccacc gtcccctgtg ttgtatccac atcaattgtc cggttcagtc cgctaatgat 2840281 accttgtgtc actgtaccgg aaaactgctg tccgagcggg ttaccgatag cgattacctt 2840341 ttcgccagtg cgcagctgtg aagagtcacc aaagctcgcc acttttttta cattcttgcc 2840401 gctgatttcc aaaactgcca aatcagtaat ggtatcgctg ccgacaagct tggcagtttc 2840461 cgtttctccg ttgtatagcg taacagtcag cttgttcgcg ccttcaacga catggttgtt 2840521 tgtaatgata tacgctttat cgctgtcttt tttgaaaata acacctgacc cggttccgct 2840581 ttcactttct gagctggagc ctcctcccgt gccgaatgtg ttattttgag aggtttggat 2840641 atttgagatt ccgacaatcg taggctctaa atcctctacc atatcagcga tgtttgatgc 2840701 gttcgttatc ggcgccgttg taaaattatc agactgcacc tgtttatttg cggaagcggt 2840761 ttcggtcgcc tgattttggt ctgacggcag ataaggcgcg atgccaagca tgaggccccc 2840821 gccgataata ccgcctaaaa tcgggctcag ccatgcggct ctccgtttct tttctttttt 2840881 cacagccgtt tcttgctttt ccatttctaa agcagaagcc gtttcctgcc gtcccgcttc 2840941 atacgacaca ggcgcgtcaa gcaattcttg ttcagaatgt ccaatcagct tctggttttc 2841001 tgtattctgc tgttctgtat gtgaaggttc agtttgatgt tgatcgtttt ggccatcacg 2841061 tcgataatcc atgttcttac actcctttaa cggttattca tttatcgtta catattcatc 2841121 gcatgtacaa gttcaattgt cccaataatg aggagaaaag caaagcacca aaatagaata 2841181 tgtttgatca tcctacatct tcctcgctct ttttctcttc ctttcttccc ttaaccatat 2841241 cataaacaaa cattgtggga taaaaatgaa aagaatatgt gaaattatga aaattgcctg 2841301 ccgtatgtta aaactagttt ataatgacgt tgaaaggatg tgaagagcct tgtcatacac 2841361 catttatcta gttgaagatg aggataacct gaatgaactg ctgacgaagt atttagagaa 2841421 tgagggctgg aacattacat cttttacgaa aggtgaagac gccagaaaga aaatgacacc 2841481 gtctccccac ctatggattc tcgatatcat gctgccggat accgacggct atacattaat 2841541 aaaagaaatc aaggcgaaag atcctgacgt gccggtcatt tttatttccg cccgagatgc 2841601 ggatattgac agagtgcttg gcttagagct tggcagcaat gactacattt caaagccgtt 2841661 tttgccgcgg gagctgatta tccgtgtgca aaagctgctg cagctcgtat ataaggaagc 2841721 tcctcctgtc caaaaaaatg aaattgccgt ctcctcgtat cgggtcgctg aagacgcccg 2841781 cgaggtctat gacgaaaacg ggaatatcat caatttgacg tcaaaggaat ttgatctgct 2841841 gctattattt atccatcata aagggcatcc atactctcgt gaggatatcc tcctaaaagt 2841901 gtggggacat gactacttcg gaacagaccg ggtcgttgat gatctcgtcc ggagactgcg 2841961 cagaaagatg cctgaattga aggtggagac gatttacggt ttcggctaca ggatgatgtc 2842021 atcatgaaaa acaagccgct cgcgtttcag atatgggttg tcatatccgg catcctgtta 2842081 gcgatatcga ttttactgct tgtgttattt tcaaacacgc tgcgagattt tttcactaat 2842141 gaaacgtata cgacgattga aaatgagcag catgttctga cagagtaccg cctgccaggt 2842201 tcgattgaaa ggcgctatta cagcgaggaa gcgacggcgc cgacaactgt ccgctccgta 2842261 cagcacgtgc tccttcctga aaatgaagag gcttcttcag acaaggattt aagcattctg 2842321 tcatcttcat ttatccacaa ggtgtacaag ctggctgata agcaggaagc taaaaagaaa 2842381 cgttacagcg ccgacgtcaa tggagagaaa gtgttttttg tcattaaaaa gggactttcc 2842441 gtcaatggac aatcagcgat gatgctctct tacgcgcttg attcttatcg ggacgatttg 2842501 gcctatacct tgttcaaaca gcttctgttt attatagctg tcgtcatttt attaagctgg 2842561 attccggcta tttggcttgc aaagtattta tcaaggcctc ttgtatcatt tgaaaaacac 2842621 gtcaaacgga tttctgaaca ggattgggat gacccagtaa aagtggaccg gaaagatgaa 2842681 atcggcaaat tgggccatac catcgaagag atgcgccaaa agcttgtgca aaaggatgaa 2842741 acagaaagaa ctctattgca aaatatctct catgatttaa aaacgccggt catggtcatc 2842801 agaggctata cacaatcaat taaagacggg atttttccta aaggagacct tgaaaacact 2842861 gtagatgtta ttgaatgcga agctcttaag ctggagaaaa aaataaagga tttattatat 2842921 ttaacgaagc tggattattt agcgaagcaa aaagtgcagc acgacatgtt cagtattgtg 2842981 gaagtgacag aagaagtcat cgaacgattg aagtgggcgc ggaaagaact atcgtgggaa 2843041 attgatgtag aagaggatat tttgatgccg ggcgatccgg agcaatggaa caaactcctc 2843101 gaaaacattt tggaaaatca aatccgctat gctgagacaa aaatagaaat cagcatgaaa 2843161 caagatgatc gaaatatcgt gatcaccatt aaaaatgacg gtccgcatat tgaagatgag 2843221 atgctctcca gcctctatga gccttttaat aaagggaaga aaggcgaatt cggcattggt 2843281 ctaagcatcg taaaacgaat tttaactctt cataaggcat ctatctcaat tgaaaatgac 2843341 aaaacgggtg taacataccg catagcagtg ccaaaataga ctgtagatgt tttgcagtct 2843401 atttttttat gtgaaagaat agccgttaaa atctctgtaa tttgttttga gcggctgttt 2843461 gcattgatga acccattttt tctctgacaa ggtctgcttc ggatatttga ctttctccac 2843521 tttgattcct ctgtttcgca agcggctgat catttcgtcc aattctctca ttctagattc 2843581 accctttcgc ttgagctttg accattcggt catctcaatt tataatataa ataatacatg 2843641 ataaaaaaac aagttacaat aaggttaatt ttataacaga cggtgtgact atatggtcat 2843701 atcctagcag gcctccgggc tccgaaaggg tggaaccatt gaaggaaaaa gaaaaactga 2843761 ttattgaaac agccttaaaa ctatttgccc aaaaaggata caactcaaca tcagtccagg 2843821 aaatcgcaaa agaatgcaaa atatctaaag gcgcttttta tatttatttt ccttcgaaag 2843881 aagcgcttct tctctctatg ctgaactact attatgataa aacgtttacc cgaattttaa 2843941 atattaaaac gaagggcgac agccccagaa cggcttaccg taaacagctg accgtcctct 2844001 atgaaaacat tcttgaacac aaagatttta tcagcatgca gttgaaggag ggttctctgc 2844061 cttacacaga agaagtggag caatgcgcaa aaaaaatccg ccagtcctca cttcaatttc 2844121 atatcgacag cctgctgaac atctatggaa aaaaagcgga accgtacact gctgagcttt 2844181 gttttttaat agagggcatc agccagattt acctggaatg catgattttg ctcgggtaca 2844241 ctgtgaagcc gtctcaatta gctgatatca ttatgaatcg aattgatgat atggtaaaag 2844301 gcatgtctga acgaaacgat aagcctttca tcacattgga agaggcgagc tctttattcg 2844361 gacctcttac gcacggacgg cctgacccgc tgactgaatc aattgtgaaa agcctacgtg 2844421 acaaaattaa cagcttaaac acaaactcct ctcttgaatt atcggagagc ttggacatac 2844481 ttgaagcaga aatgaagaaa aaaacaccga agctggcgat cataaaagga atgattcata 2844541 atctgacgga gtctgaagct ctcgccaaag atgcggaaca gcttaaatat ttattaaaac 2844601 agcaacatat ttagaagaac ggctgcttaa aaagcagccg ttcttcctat tacgcctttg 2844661 gttttaccat gtcttccggc ttaaccattt cgttaaattg ctcctctgtc agcaattcaa 2844721 gcttcaaagc tgcttctttg agcgtcaatc cctctttatg ggcaagcttg gcgattttcg 2844781 ccgcgttttc ataaccgata tgcgggttca gcgccgtaac aagcattaat gaatttgaca 2844841 ggttttcctg aatggtttct ttattaggct caataccgac agcacattta tcatggaatg 2844901 aattcatgcc gtcactgagc agctgcacag attgcaggaa gttgtaaata ataacaggct 2844961 taaacacgtt cagttcaaag ttcccctgac tcgccgcaaa gccgattgtc gcatcgttcc 2845021 ccatgatttg cgctgcgatc attgttaacg cttcgctttg tgtcggattg actttaccag 2845081 gcataataga gcttcccggc tcattttcag gaatgacgat ctccccgatg ccgcagcggg 2845141 gtccgcttgc gagccatctg acatcgttcg cgattttcat taagtcagcc gcaagcgctt 2845201 ttaatgcgcc atgcgcataa gtgatttcgt catggcttgt cagcgcgtgg aatttattcg 2845261 gcgagctgct gaacgtttgg ccggtcagct tagtgatctc ttctgagaca agctctccaa 2845321 actctgggtg ggcgttgata cccgttccga cagccgttcc accaattgca agcgcacgca 2845381 ttttatctgt cgcttccaaa atcatttcct tcgaacggtc cagcatgtga acccatccgc 2845441 tgatttcctg tccgagggtc agtggcgtag catcctgaag atgcgtgcgt ccgattttga 2845501 caatatcatt gtatgctttt gctttttcat ccagtgtatt gcgaagctga tcaagcgccg 2845561 gcacaagctg ctcgtaaaca gccaaaacag cggcaacatg catcgcagtc gggaatgtgt 2845621 cgtttgagct ttggcttcgg ttcacgtcat catttggatg aatcgtttga tcagagttct 2845681 tctcttttaa taaagcagtc gcacggttgg ctaccacttc gttcatgttc atattgcttt 2845741 gtgtgccgct tccggtctgc catacgacaa gcgggaagtt gtcatcgtac ttgcctttga 2845801 gcacatcatc acaaaccgct gcaatcgctt ctgctttttc agcgtccaga ttgccgaggc 2845861 gtttattagc tagagcagtg cttcgtttta aaattgcaaa cgccttcaca acacgcatcg 2845921 gcattttttc agaaccgatc ttaaagttct ccttgcttcg ctgtgtttgg gcgccccaaa 2845981 atttatcagc aggaactttt acttctccca tggtgtctcg ttcaattctg tattccattt 2846041 atgtatccct ccataacggt tgcttcaata gatcataatt cgccaatgac acaaaaaatc 2846101 ctttttattt ttcgatcttg gcagatttta attttaattc aagatatacg cgggaatcct 2846161 ttgaatattt gtattttgga tttgtcctgc cgtactcctt tgatgtataa gagacatcat 2846221 aatgctgttc aaatgatcta atgagctgtt caatttcttc ttgttttcca gctagcctta 2846281 cctgtgccac ttcgtatcct ccgctttcat aaaaaaactt actccatgaa atactctaac 2846341 acagtatatc atttttttaa caggaaaaga taacctctac taaggttttg gataagaggt 2846401 gacctcattg gaacaaacag agtttaagga atatatacac gataatttag cattggtgct 2846461 gccaaaatta aaagaaaacg atgatctggt gaaaaacaaa aaaatgcttg cgaacggact 2846521 ggttttttac tatctctatt tcagtgaaat gactgatgag aataaggtgt cagaagccat 2846581 taaaactttg attaaagatg aggagacctt aacgcttgac caggtcaaaa aacgccttga 2846641 ccagcttgac gcaagacctg ttgaaactgc aaaaaaaacg attgaatcga ttctcaacgg 2846701 caattgtgct gtgtttatca acggattgga taaagcctat attctgacca caggaaagaa 2846761 aaaaacaaga agcctgacag agccgacaac tgaaaaagtg gttcgcggcc caaaagtagc 2846821 gtttgtagag gatattgata caaatctcgc tctgatcaga caaagaacct ctcatccgaa 2846881 attgatcacc aaaaaaatca tgatcggcga aaacaagctg aagcctgcag ccattatgta 2846941 cattgaaggc aaagcaaaaa agtccgtcat aaaagaagtg aaggcgcggc ttaaaaatat 2847001 ccagctggaa gatatccagg acagcggaac gctcgaggag ctcattgaag ataataaata 2847061 ttcaccattt ccgcagatac aaaatacgga aagacctgac aaagtatctt cagccctgtt 2847121 taacggccgt gtggcaattt tggtcgacag ttcaccattt gtgctgctgg tgccggtttc 2847181 tctcggcatc ctgatgcaat ccccggatga ctactatgaa cgctggattt cagcatctct 2847241 tatccggtcg ctgcgctttg cttctatctt tatcaccttg tttttgtcat cgatttatat 2847301 aacacttgtt tccttccatc aggggctgct gccgaccgca ctcgccgtca cgatttcggc 2847361 gaacagggaa aacgtgccgt tccctccgat atttgaagcc ctgctgatgg aagtcaccat 2847421 cgagctgcta agggaagccg gactgcgact ccccaatccg ctcggacaga cgatcggcct 2847481 cgttgggggc gtagtcatcg gacaggctgc tgtagaagcg aatctcgtca gttcgatttt 2847541 ggtcattgtc gtcagtgtca ttgccctggc atcctttacc gttcctcaat acggaatggg 2847601 tctgtctttc cgggtgctgc gttttatttc gatgttttcc gccgctattt tagggctata 2847661 cggcattatt ttatttatgc ttgtcgttta tacgcactta acgagacaaa cgagctttgg 2847721 gtctccgtat ttttcgccaa acggattctt tagcctgaaa aatacggatg actccattat 2847781 ccgtctccca attaaaaaca aaccaaaaga ggtgaataat ccaaatgagc caaaaacaga 2847841 ctccactgaa acttaatacc tttcaaggta tttctattgt tgcaaataca atgcttgggg 2847901 ccggactttt aacattgccg cgagcgctga ccactaaggc taatacgcct gacggctgga 2847961 tcacgctgat attagaaggt ttcattttta ttttcttcat ttatttaaac acgctcattc 2848021 agaaaaaaca tcaataccct tcactctttg aatatttgaa ggaagggctt gggaaatgga 2848081 tcggcagcat catcggcctt ttgatctgcg gctatttcct cggcgtagcc agcttcgaga 2848141 cacgggcaat ggctgaaatg gtgaagtttt tcctgctgga gagaacccca attcaagtca 2848201 ttattttaac gtttatttgc tgcggcattt atttaatggt tgggggctta agcgatgtgt 2848261 cgcggctgtt tcccttttat ttaacggtaa ccattattat tttgctgatt gtgttcggga 2848321 tcagttttaa aatttttgat atcaataatt tgcgtcctgt tttaggcgaa ggccttggac 2848381 ccattgcaaa ctcccttacc gtcgtttcca tctctttttt aggaatggaa gtgatgctgt 2848441 ttcttcctga acatatgaag aaaaagaaat acacgttcag atatgcgtct ctaggatttc 2848501 tgattccgat tatcttatat atccttacgt atattatcgt tgtcggagct ttgaccgctc 2848561 ccgaggtgaa aacgctgatt tggccgacta tttctctctt tcagtccttt gagcttaaag 2848621 gcatatttat tgaacggttt gaatcctttt tactggtggt ctggattatc cagtttttca 2848681 ccacatttgt catttacgga tactttgccg ctaacgggct aaagaagaca tttggattat 2848741 cgactaaaac aagcatggtg attatcggca taacggtctt ttatttttct ctctggccgg 2848801 atgacgccaa tcaagtcatg atgtatagcg attatcttgg ctatattttt gtctccctgt 2848861 ttctgcttcc gttcattctc tttttcattg tagctctcaa gaggaggatt acaacaaaat 2848921 gaaaatccgg attttatgta tgtttatatg caccctattg ctgtccggat gctgggacag 2848981 tgagaatatc gaggaattaa gcttagtgat cggaataggg ctagacaagc ctgacgatga 2849041 aaatttagag ctgacacagc aaattctcgt gccgaaaata atcagcgcca aggagggctc 2849101 ttcatctgat ccgacacagc tttctatcac aaagggtaaa actgtccatc aaatgatgag 2849161 aacctctgca ttaaagcata agcctacgtt ttcacagcat ttgcgtctca ttctgctttc 2849221 caaaagcgtg attgcggatc aaattggaat ggacgccatt attaaccagt ttgtcagaga 2849281 caacggaaca aggaggagtt cctacgtctt tatcaccaac ggccgaacta aggatatatt 2849341 taacatgaat gatgaaggcg aacccgcatc caacgtgata tatgatctga cagagaataa 2849401 taaggtgacg atcagaacga tggagccagt tacattgggg gagatctcag aacacttaac 2849461 ctctgacgat tcattcctca tccctcatgt cggtaaggaa aacggcaagc tcgcgataaa 2849521 cggagcctct atcataaaaa ataaattatg gcaccgggac ctcaccccga ttgaggttca 2849581 aaatatcagc ttattttcag gcactgtcga gggaggcgtc attgacttga agcgcgatgg 2849641 ccatctcttt tcttatgaag tatattcaag caatcggaag atcaagacgg catacaagga 2849701 cggaaagttc aaattcaccg ttacccgcaa tattgaaggt cgtctatctg aggactggaa 2849761 tcccaatgaa gactcgttta aggattcata tattaaaagt attgaaaaga cagtcgaaaa 2849821 acgagtacac gaaacagtaa cgtcatttat tacagagaag ctgcagaaag agatcaaagc 2849881 ggacgtaacc gggctgggaa acgaggtcag aattcattat cctcaaaagt ggaaaaagat 2849941 ttcaagaaaa tgggatgatg attatttcag caatgcggaa atagactacc gggtcaatgt 2850001 gattgtcaga gacttcggaa cgaaaggcgc aaacaaatag cagccgccta attcacgaga 2850061 tgatttcggt gtgcgtacac cgccgcctgc gtccggtcac tgacatccag ctttgataaa 2850121 atattcgtaa tatgtgtttt gactgtttta atcgtaataa acagttcctc gcctatttct 2850181 ttgtttgtct ttccttctgc gatcaggcag agtatttcga gctcccgttt tgtaagcgat 2850241 tcatgcggga gcgcgttttc acctgagtgg cgcagcctgg ataatacttt tcccgccact 2850301 tttgactcca gcttcggctc tcccttgctt gcggcgcgga tggcatcggc gatttctgcc 2850361 gcttttgagg ttttcaacag atagctgagc gcgccagctt caataaccgg gtacactttg 2850421 tcatcatcaa tgaagctagt gagcacaata attttcgggt cggaaagctc ccggcaaatt 2850481 tgctttgtag cttcaatgcc atccatgccc tccatgacaa ggtccattaa aatgacatca 2850541 ggcgacagtt ccacagcaag ccgaacacct tcgctgccgt ccgatgcttc gccgatgact 2850601 tcaatatcgg gctgcgcctc caaaaaagcc gcgagcccca ttctgaccat ttcatgatca 2850661 tcaatcaata atactcgaat cacgttcgtt ctctcctttt tcttccggaa aaatcgggac 2850721 cttcacttcg atttgagtgc cttttccttc tactgaaatc acttcggcga caccgccgat 2850781 ttcacttgca cgttctttca tagaattcaa gccgtatgag gaggctttca cctggtccat 2850841 tttaaagcct tttccattat caatcacctt cagacggagc tggctgttct ttatgcccag 2850901 aatcacggtt acttttgacg cttttgaatg tctaaatacg tttgaaaggg cctcctgcac 2850961 gattctgaac aagtggtctt caacaccctt ggatatcgct gtgtcctgta tatcccactc 2851021 aatatcaatc ggctgctttt ttcggaactc gtccaaaagc tccgtaaggc cctccttcag 2851081 cccttttcct tcaagggtaa caggccgtaa atggagcagc agcgccctca tctcattttg 2851141 ggcttcgcct gccatatgct cgaccatcct gatccgcttg actgttttgt catcagcatc 2851201 cttgacatgt tccagcacgg ctgatgtcat catcgatatg gcaaagagct gctggctgac 2851261 cgcatcatga agatctctgg ccaatcgctg gcgttcttct gagataaccg acttcttcat 2851321 ttgagcctgc cattccgcac gttcattgga aagtttctgg agggatgcga cttgaagctc 2851381 cacgcgcttc gccatttcgt tcagctgatc agcagccagg ccgatttcat catcaccgag 2851441 cggcggtatc cgataagcga aattgccgtt ttcaaaggtt aaaatggatt caattaatgt 2851501 atcaatcctt gtcttcaacc ggttgccgta catataccct gaggcgaaac cgacggtcac 2851561 gctgatcaga agcaaaatca ggataaacgg aattccgaac cagcttgatg acagcaaaac 2851621 aagcggatcg agccgatagt aaaacatcat aaaggaaatc aggcaaacaa aaaggagcag 2851681 gctgattccc gttgtcatgc ggatggcgcg ccattggagg ctggcaagca ttttttttct 2851741 catacgtact tcacatccac atcaccgata aataaggaaa cggacacttt tacccggcgc 2851801 tttgactcgc taaaatcagt tgacgcggca tataccttcg tgcttaatcc gcttttcttc 2851861 gagccgatca gattaatgtc tcctataaaa acagccgagc tgacagccac ttcaaggtcc 2851921 gatggtacat aaatatcaac gttaccaatg actccgctaa tgacgattgt actttctccc 2851981 tcgggaatca tcgctttaga taaatcgatt ttgatatcac cgataaaacc agagacattt 2852041 aaatcgttca ggtcaaacgg ctgcttcatc atttgcagct caccgataaa aaagctgcgc 2852101 atgtcgggat gttttacatc ttttggcggc tcatgatgtt cttttttatt gagattgacc 2852161 tgtttctcat tcggttcaaa tatcggcttc cctttgataa gcctgtagcc ggcgtaaatc 2852221 agaaatgcgg caaacgcata gccgaataaa ttaaaggtga tgctgaagag gtttttcaaa 2852281 aatagaaacg cggcaaagat atacatgacg gagccaagcc aatcacggga atatttttta 2852341 aggaaatagc cggcaatcag aaaaaagagc ggccaaaaca gcagatcgcc tattccgata 2852401 atttgcaaaa acatactgat gccgaataaa gcaatgatca atccgagaag ctgttttttt 2852461 gtcattcctg gtgtccgcct cctttcttct gcctagtgct accgtatcgc tagatccccg 2852521 ctgtccgttt tgatgtcgat tggatgccgg ccgcttcctt gcgtgcctgt gatgtgatgc 2852581 tgttctttat gtcctttatc agcaaatgaa tacggcgaac tgacgtcacc gcttgctgat 2852641 aaagcattga ctgcaaagct gccattttgg ggaaggctta cattagcatc accgcttgtc 2852701 agcgtgacag atacgggacc ggttaccttt ttcaatacag cattaaaatc tcctgaagtc 2852761 attttcacat caagagagcc tgatacatga accagatttg cgtcccctga agctaaatca 2852821 atgccggctg ttttggagac ggtatttgaa atggaaacat cccccgatga tgccttcact 2852881 ttcagatctt gaatgcggac gtccgtcacg ctcgtatttc cgctcgcaga tactgcgttc 2852941 agcccggaaa gcgcaagatg gtcattcccg gccacagaca cgtcaccgct tgaggttcgt 2853001 actgccagat cacctttata atcatacgga agcctgacga taagagttga acggttaaat 2853061 ccattcaaaa attgaaattc tttttccttt acggtcagct ccagttttct tttgttttca 2853121 gtaacaaata actttcctga gtctcctgaa atgcctgccg atatgtcact tcgttcttcc 2853181 gctataatcc ggacatcctt gctatccgac tcaatgacca tgctgtcaat gtcccgcggc 2853241 gatgcgctgg ctgaatcagc ttctgtgcca tttatgaaac ctaggcctgc agcaaacaca 2853301 tcttttacga cgacggcgaa aaaaaccaga ataccggcag tgatcaacag tttgccaagc 2853361 atttttttca ttcggtttca tccttctcat tcattctatt ataaaggaaa agcttgcgaa 2853421 ttgatacgtg cggaagggaa ggacttgacc gcaaatcctt ccccgttccg cttattcatt 2853481 tgccgctttt gtctggtctg atttttgcag tgaaagtgtc cgcatttttt caatctccgc 2853541 ttccacatcg tctgcgaatt ctttacgtgt aagttctgtg ccggcttccg ctgactttga 2853601 ataattcgcg cggatttcca tttcttcaat acgattttca atacgtaaaa attcacgata 2853661 cgcgctttca ctgtcaattt tgtcaaatgt cgtattcata tgctctttag ctttcgccgc 2853721 atttgcccgc gcaatcagcg cctgtttttt atcctttacg tcctgaagct ttgtttcaag 2853781 tgcagccagc tgctctttca gatcagccag ctgactgttt gcctgttcat aggaagcttt 2853841 atgctcagcc gccttccctt ctaaatactt catttcagtc agcgcctttt tcgccagttc 2853901 ttcttcacct gcgtcaaatg cgagctgtgc ctgatttttc cgtttgccag ccacttcagc 2853961 ggcttcttca tattttttct taaattgata ggcaatcgtg tgctgtttca caattgtttg 2854021 ctttgctttt gcgatgtcgc tttccatatc gcgtacatat tgattcagca tcacctttgg 2854081 attctccatt ttatcaagtc cttcatgaac tgacgcaaca aacatgtctc tgattctttt 2854141 taataccata cctgattcct cctaatatat tgatattatt ttttcttcaa aaattcttcc 2854201 cattcgtcat caaagtgaga ttggtaggca gcagaagccg gttcaggatc aaaagatgat 2854261 acaccgttat cagctgatcc gtttttcatc agcttccagc cgtaatacac catagcggcc 2854321 gccaatgcga ttccgacgac aaacggaagt gagcagatga gcataatggc tccgataccg 2854381 cccacgatga ttcccgtgat ggtttttccc gcggcaaacc ttttgattcc tgcgtatgtc 2854441 atcaagctcc cgatggcgag cgggatgata aagccgaagc ttcctcctcc aaaaaagacg 2854501 gagatcccaa atacaattaa taagaatccg cctattgttt tcttgtttat tttcatgcag 2854561 atcctccttt cgttttcctt gtcttcatct tatacaagtt ggaagatatg caaaacgaat 2854621 cagagattga tttttatata agaccggagt cgtatctcgc accggaccca ttggcacaaa 2854681 aaaacgccat gcacgaggca tggcgtttta aaacccttta cagatgaaca cttgcttccc 2854741 tttctttaat taggtcggac ctttctgctt tggccaattt tgtaaacagc aagattccga 2854801 tacccgcaat aatttcgaca atcccaccga cagcgatcac tttacctgag ccgaaagcat 2854861 tagcggcata cccgcaaatg acagctccgg cagggatcga aatatttgag atcatatgta 2854921 taacggcgta aacctgcggc tgatcctcac tatccacaga cgtctggata atcgtgtact 2854981 caggaacatt aacagcactg actgcggcac caaaggtaaa agcagcgaaa aagacgagcg 2855041 gcaaaaaggt attcatcccg gtaataaaga aagcaaatcc ttcaataatg ccggcagtga 2855101 cgaataacaa gccgtacctg tttaccttga ctttcgccag cacaaaccct aataaaaacg 2855161 cgcccgcggc ggtggtggcc tttaaaagcg agtatacgat cggctggccg tttaaatctt 2855221 ccgcaacgta tacggcagag agcgcttccc atggggcagc cgcgaaattc ataaagatac 2855281 agtaaatggc gagcggatat aaaatctggt gttttctgac gagcctaaag ccgcgtttca 2855341 gtcttccgat atatgtgcct ctctgtgtaa caaccgcaga ctctgattga gattcaaccg 2855401 cagtgtactt aataaaaaga acgagaaaac ctgacaccaa atagagcaca agtgcgataa 2855461 gcatggtata agaaggacta ataaatgtaa gaaaagcgcc gcataatgtg acagccccaa 2855521 gccggacaat ttgagcggag gattgcagca cagcgtttgc tttttgaatg ccctgttcat 2855581 tgacgatttg aggaatcaaa gcgatagagg cgggattgta ggcagctcca gtagctgaat 2855641 gcacaatcat aagcgtcatg acaaaccaca gcggagagaa gcccgcaaaa tgacatagag 2855701 ggataatcaa aacaatcgcc gcccttgtca gatctgaaaa gtacatccaa aatttcagcg 2855761 tggtctgttt cataaaaggc cccgtcacag gcgccagaac ggcttccggc aaaaacgtga 2855821 cagcaatcaa taaagcagtg ccgatcgcac ctttgccgtc ataaattaaa aaccataata 2855881 ttgaattaaa tgcgaacata tcgccggata tcttgactat tcttgagaaa aacagataat 2855941 tgaaatttct cttccagatg ctatcacttt caattaaatt caccatccat cagagccccc 2856001 cgttgcctat tttttacatc tatttattac aatatctcat ttttccattt ttcagtcaat 2856061 aattcataag gttcattttt tgtcgtaaaa tgggaaattg acagagtgaa aaacaaaaaa 2856121 agccggcatg tatttgaaca cgccggcttt ccttttcact ttttatgatt cgctgctgtt 2856181 tcggtcccga aacacaatgg cacttctttc atattctaca tcgccaatac cgcttcttgc 2856241 attcacaacc cgggcggcgg caaagaaata atcggacaga cgattgagat aacgcagcac 2856301 tgtttcatga atctcctccg atttcatcag cgccaccact cttcgttctg cccgccttgt 2856361 aatggtgcgt gcgatatgga gaagcgaagc acactttgat ccgcctggaa gaataaattt 2856421 cttcagttcc ggcgcttctg ctgtataggc atcaatgcgc gtttctaaaa aggaaacaga 2856481 ttcttccgtt agtttatagt cttttctttc tgtgacgatt gccagatcgc ctccgcagtc 2856541 aaacagctca tgctggatgg tcagcagctc ggctgtcaga tcttcaaagc cgggctgccc 2856601 ggaaagctct gccaaagcaa gcccgataaa gctgttaagc tcgtcaatcg tgccgtagct 2856661 ttcgacgcgt aggctgtcct tgtccgttct gcccccgact aagcccgttt gtcccttatc 2856721 gcctgttttt gtatatagtt tcataccctg aatctccttt acagacttat tcaaacaact 2856781 cagcagcctc ttttatacat tcagctgtcc ctttctttat caattggttc agccgctgtt 2856841 ctatgttttc tgattgctga gtttgagtcg cggcgatgag aatatcacct gtgcctcctc 2856901 cgtctcccag cactttcgtc cgttctgctt cggcagccat aagagctttg atgaagaatt 2856961 gatctgccgc atagccgtta atcaaaatcc aaatcgaaaa gccggtctga acgcatatga 2857021 aaacggataa ctctccgtct tcatatgttc gatacacgaa acggtcaagt ctttctgaag 2857081 aagccatcgc acacgtctcc tgcagttgaa aaccgctttc tgaaagacag gccgtaagtc 2857141 cttctatcgg atctggctga tctggcagcc gtttatggat cagcgtcctg ctccacgaaa 2857201 accctgcacc gataggcgtg gaggacaatg ttcgaagcgg gatttccgtt tgcagaagaa 2857261 tgtcatcacg ccccgcttgg agcaatgctt caaatgggat agactgccgc ttcacgctat 2857321 ctttttcagg ctgaatcaca atcatcggtt taggtgagct ttgatgaacc aaggcggtga 2857381 catctgtatc gtacaccgcc tttatgcttt gttctgtaac agcatattcc ggtttttgct 2857441 taggcccggc ggtaccgttt ttcataaaca tgagcccatc acagtacagg cttgcggtgt 2857501 tcagatcatg aaaaacgctg acagctgcca atccgctttc tctcgtcagg cgtttgatca 2857561 gatcaagcag gtctttttga taagccagat cgagaaaatt agtcggctcg tccaaaaata 2857621 aaatacgcgg ctgctgcgcc aaagcttgtg ccaaatacac ccgctgctgt tcccctccgc 2857681 ttagttcgcg aatcggcttt tgcgcaaaat cggccactcc tgtttgctcc attgcttcct 2857741 gtacaatggc ttcacccttt tcagtctgct gtctgaacag ccccgtttgg aatggatatc 2857801 tgccaaaggc tacagtttct tcgacagtaa aggtgaaggc ttgatccatt ttttgcggca 2857861 ggacagccat gatttgcgcc agttccttcg gtttatagtc cgccagcagt tttccggcca 2857921 gataaaccct gcctttcttg gccggcagcg tacctgtcag caagtgcaaa agcgtggttt 2857981 ttccgcttcc attagggccg agaattccaa gaaattctcc cttctccact gttaagctga 2858041 cattgttgat taggcggctg tcgccgtatc ctcccgacag cccttctgcc ttcatcataa 2858101 gcttctcccc ccgcgatgct gccgaattaa aataagagcg aacacaggcg ctcccgccaa 2858161 ggacgtaatg atcccgatcg gcagttcaat cggctcaatg atggttctgg aaagcagatc 2858221 ggctaaaaca agaaaccctg ccccaagcaa ggcggacaac ggcagtaaat gccgatggtc 2858281 cgttccccac aaaagccttg tgatatgcgg aatcacaagg ccgacaaagc caatcgtacc 2858341 cgatactgcc acagcgcttc ccgtcaaaag agatccggct attaaaatca tcatcttcct 2858401 ctgctgaacg ctgactccaa gaagctttgc tttatcttct ccatatgtca tcacgttcag 2858461 ttcccttccg tttataatca ataaaatggt tcccaaaaga aaaaacggga gaaacaaaat 2858521 aacatagctc cagcccctca ttgagacgct gccaagcagc caatgcacaa tcggaagcag 2858581 gttgtctcct gtcaaggcga tgataagaga aataaatgcg cctaaaaaag agttggtgat 2858641 gacaccggtc aaaatgaggg tggaaacaga catcgaagca tgaacgaggc ggctgaagaa 2858701 aaggaccgcc gccatcgtgg ccagtgccgc ggctacactc aaaaccggga gtgtaaaccc 2858761 tccgatgaca ggaaggtgca aacctaagaa cagagtcaca acagctccga ctgaagcacc 2858821 ggatgacaca cctagcgtat agggatcagc aagcggattt ttcaacaatc cttgaaaagc 2858881 ggcccctgca atagaaagag ccgcccccac aagggcggcc agcacaactc tcggcagtct 2858941 gatattcatc ataatattag tgtacatcgg atcatcagaa ccgatagagc cgccgaaacc 2859001 ttgatgccaa aagacacgaa aaacagcggg aataggaata tgcaggctgc cgcaagaaat 2859061 tcctaagatg atgctcacgg ctaaaaatga gaaaccaatg atatatgcgg cataacgatt 2859121 attccttaaa cgtatccggg taaatgcttt ccgcaagttc ttcgacccct tcgatcagac 2859181 ggggaccgga acgtgtcaca agatcagggt ccacatcata tacacgatga tgtttcacag 2859241 cattgatttc gctccagcca tcgcgttttt ccacagcttt cgctttcaca ccgtccgttg 2859301 taacaattgc atcaggattg agttttacga tcgcctcgtc tgtcatttgc acccatcctg 2859361 tctgatccgc agctgcgttt ttagcatgga tgacatttag catttcattc ataaacgtat 2859421 cttttccggt tgtataaatg tcaggatcag gagaaacctc gataaatacg cttttctcct 2859481 cgtcttttga aatggttttc gctttttctt gaatatcctt tagatctgat ttcatgcttt 2859541 tcacgagctg atcggctttt ttctccgccc cgccagcttc tccgatcatt tcgattgatt 2859601 tgtacacctc ggagaatgat tgtgcatcat tgacagtcag cactgtaatg cccgcgtcct 2859661 tcagctgttt gatggcatcc gctgatgctg acatggaaga ctcatgggcc agaacgagat 2859721 ctggttttag agaaatgact ttttcaacgt ttacattcat atctccgact ttctcaacct 2859781 ttttgacttc ctttggatag gtatcgtttg tggtgacacc gaccactttg tcaccaaggc 2859841 cgagtgcgta tgtaatttct gtgttgctcg gcattaatga aacaatcttt tttggctctt 2859901 ttttgatggt tacatcttgg tttgacgcat catcaatggt gacagggaac acttctgttt 2859961 tttgttttgc ctttgaatcc ttctgatccg caggattgcc gcagcctgcc agcataacag 2860021 cagccaacag aagcgcagcc catatcccgg ctcgtttttt cataatcttt tcctcctaaa 2860081 cgaactaaaa aagcatctct acgacggtaa agatgctgta aacaacacaa aaaagcctat 2860141 tgtttacaca tcatctgtcc tcgcagaatt cgtgctgatc aaacaggcag gtatcctggc 2860201 tcttggcgct tggccaatta cagtggcggg accgcaccgg cttttaccgg tttccctttt 2860261 aagccggctg ttgttcacgg accggcacct atttgacatt cgtatccgtt tttcggagta 2860321 attatactat atgactgaca ggcttgtata tgtgtcctga atgacttttc cccatattgt 2860381 gtatggaagc aaaatcctcg taaacactaa atttgatctt gtatacttaa taccatcatc 2860441 tatcaaaagg aatgattctt atggatttac agctaaaaga aaaactcgtc ttaatcaccg 2860501 gctcgacgtc cggtatcggg aaagccgccg caaaaagctt tctgcaagag ggtgcggcag 2860561 tcattgtcaa cggacgcaaa caggagactg tcgatcgcac cattgaagag ctttctggct 2860621 atggaacagt gcacggtgct gctgccgatt tgtcaaaaac agatgaagca gcggctttta 2860681 tcgaaaaagt aaatgaaatc ggtgatatcg atatccttgt caacaacctt ggtttcttcg 2860741 aggtaaaaga cttcgccgat gtgacagatg aagagtggaa tcaatatttc gaagtgaacg 2860801 tgatgagcgc cgttcggaca agccgtcact tccttccaaa aatgcttgcc aaaaacagcg 2860861 gccgcatttt aaatattgca agtgaagcag gcgtcaaacc gctgccaacg atgattccat 2860921 actcaatgac aaaaacggca ctgatcagcc tttcaagagg aatggctgaa atgacaaaag 2860981 gcacaaatgt gacggtcaac tcagtgctcc cgggacctac ttggacagag ggcgtggcct 2861041 cctatatgga aggcgccgca caagcagccg gacaggatac agatacattt atcaaagact 2861101 atttcaaggt caatgagcca acctcactta ttcagcgata cgcgacagca gaagaagtcg 2861161 ccaacacaat cgtattcctc gcgtctgacg ccgcatccgc cattaacggc acggcacagc 2861221 gtgtggaagg cggcattatc cgttctctgt agtataaaaa aacgcatccg tgtttcggat 2861281 gcgttttttt tatacgtctc cagcaaatgg taccggctga tatccgcctg tttccagttg 2861341 tgctgaaaac aaccctccag cgtgaggctg ctcgtatctc tctttttctg tcatttgttc 2861401 tgttgccgtt gtaatgtaaa gggtttttaa gtctctgccg ccgaacgcgc agcacgtgac 2861461 atatttagcc ggcacgctga ttgaattgat ttcttttttc tgaaacgggt caatgtgaac 2861521 aacgcggctg ccgccaaaca gcgccaccca cagcatgcca ttttggtcaa ttgtcatgcc 2861581 gtccggcaat ccgtctgact gatcaaaacg atagacaggt tctggattcg aaacatctcc 2861641 gctttgagga tcatagctgt aacgtacaat ctcctgggtc ggcgtgtcga tgtaatacat 2861701 caaattccgc tcgcggtccc aatccaaacc gtttgaggtg gagacttgat ccttgatttt 2861761 gacaagactg ccgtctagat tcaaacggta cagcgacgcc tgtttttgct cgccttccat 2861821 gctcgtcgtc cccgcccaaa gccttccgta cgggtcacat ttagcatcat taaatctcag 2861881 gctctcatgc atgtccttcg gctgtttaat tttttccaag ctgtcatccc gaagatgata 2861941 caggtaaaac ccgtccttca tcgtcataat cagttcatcc tttgaatatt tcgcaagcgc 2862001 cgtcacaaag gatttgaatt tgattgatcg gttgattttt tcttcagggt caaagatgtg 2862061 gagctcgctc cccaggatat caacccaata taagcggccg ttctcttcat cccataacgg 2862121 gccttcacca atcactgccc gagtgtctgc ttccaatact gcatccatgt gttacacctc 2862181 tttagcttca gtctatatat tgttattccc ggcaaagagg tgtccaaacc acttgatgtt 2862241 tattgttttt taaaaaggat ggtaatgacc gttccaatgt tcgttctgct gttcacatgg 2862301 atcgttccgt tatgcagatg gacaagctcc ttggcaatcg cgagcccgag acccgttccg 2862361 gcagttgaat cttttgtgtt cgtccctctg tagtagcggt taaacaaatg ggtgatcgtt 2862421 tcttcatcca ttcctttccc attgtccttc acttttaaag aaatatgatt ttttgtttgc 2862481 tccagaatga cttgaatctc tgttcctttg ccgttgtgct tcacggcatt cccaaggagg 2862541 ttttctaata tgcgcctgaa ccacgcttca tcaagggcaa attcaatatg ctcttctttg 2862601 gatacaaacg agatatcata gccttcagaa aacggatttt tcttaaaatc ctcaatgaca 2862661 tttttaaaaa acgggataag gctagtgagc tttctctcaa taggaagagc atcatttttc 2862721 aggcgatacg ttaaatttaa gtcttcaatc agcttagaca tgtattcaga tttttctctg 2862781 acaacctgcc ccatttcttt cacttcttcc ggcgaccagt catactgctt cgactcgagc 2862841 atcatgctgt agccgtaaat gctgctgagc ggtgttttta agtcatgtga caaaccggca 2862901 atccattctt cccttgtcgc ctggattttt tctctgtttc ttttatccct tctcagcgtt 2862961 tcagtcagct gatccattga ttcaaatatc tcaccgaaga agcggtacgg ctgtttgatt 2863021 tttccctttt tatttttgct gacaggacgg ccttcccggt ttctgggctc ctcaagcttc 2863081 ccttttgaca gattgaccag ccatctaatc gtgtgaaaaa tcggcagccc gaatcggaac 2863141 atataccaaa cggtcatcca aatgatatac atgaacaaaa cggccatcac gagaaacatc 2863201 gcttttaata caaccttcag gaatgatttg ttaaactcct gatcggttac atagactggg 2863261 ttcggcaccg tagcgaccat ccatctgtct ttattgagga tcttaacgga aatttcccgc 2863321 ttatagttcc aaggcttaga gctgtattta agcagctcca gctggttcat cgtttttctc 2863381 tcgctttttg tgctgttgat gctgtcgaga atctttccat tgctgtctaa caggtaaatg 2863441 gcgccttttt tccgtttaat atagtcgatg gtactagact tatagtgcgc tagtgagtct 2863501 atcttttgtt cacgcttttc aacggaagtc aggagctgtt cactttttga tttccagccg 2863561 gacaatagaa gatacgactt atcttcaata ttgatggccc aataattcag tttatagtta 2863621 tgaagctttt tggttttata aatagacaaa agctctttct tggtataggt gcccggcacg 2863681 tcttttggca cgccgtagga ataatcagtg tttccttccg aatcaatgat ttgcatccag 2863741 ccgtgctgtt tatcaacaga tttcttcagg aaattatcca cttcccatgt cccgtcttcg 2863801 tttacatcga gatatgcctc aagtgtgtcg gtcgttgctt tcgtcagccc tgaattggat 2863861 tccgcatcgc taaaacgggc gtctaaatag aaaaacgatg caacaagcat aaccgtaagc 2863921 agcaggatca caatcagcat ctggccgaaa aagtgaaaca aaaacttcca tcttaacctc 2863981 atgaccgctt gccttcagga tttgggataa aacgatagcc gagacctcga acggttacaa 2864041 tatactccgg attgctcgga tcgcgctcaa tcttctccct aagcttgcga atatgaacca 2864101 tgacggtgtt gttgtcaccg taggaaggat agccccatac tttttcatat atttgatctt 2864161 tggaaagcac cacgttaggg tgttcacaaa aatactgcaa aagctgcaga agctgggctg 2864221 aacaggcaac ggcttccccg cctacgatca actcggcatt ttgcggagaa aaagtaaagt 2864281 aatcatatgt gtaggtttga tttgaactcg tttctttcga ttgatatgta cgcttgagat 2864341 gcgctctgat ccgcgccgct aattccagcg gattaaatgg ttttgtgata tagtcatcag 2864401 ctccaaccgc aaagcccgat aatttgtccg cgtcggatga tcttgccgtc aggaaaaaaa 2864461 tcggagcgtc tgaatactct ctgatcaatg tgcaggcttc aaaaccggac attccgccca 2864521 tcatgacatc cagcacaatc aagtcaacct tattggcctt cacaacggga atcgcttctt 2864581 ctgcgcttgc cgcatccagt atatttcgat aaccttcttt ttcgagaacg cgtttgatca 2864641 tgtccacaat cgctttctca tcgtctacga ttaaaattga cgcattttcc acttttatgt 2864701 tcctttctgt cactgttttt ttcatcttat cattatatcg tttatttatg gtacattttt 2864761 gaatacattg gagccttggc aaatcaaaac agcaaaaaag gagcaaacaa gcgctccctt 2864821 ttgatgtttt ttcatatgaa aatattatga gttctcatct accatgtaca aaataaactc 2864881 ccaaaacccc ggtacatcct gacataaaag catatcagcc ttttcaaaca ttttgatctt 2864941 cagctcttgc tctaaatctt ctctttcttg ataggacgta ttgctgagtt tttttctgat 2865001 catcggtgaa aagcatgcaa tcaggtgctc aatgtcataa gtctcgtctt tttgtttctt 2865061 tttttgttca aactggccgt ccacagctta cttttccccc tttttttgcg ccgctaactg 2865121 ctttctgata ttctccagcc cctttttatg aatgttggag atgttttgtc gggactcccc 2865181 taatgaatct gcaatctcct gcatcgtggc accgtgaaga tagactttcg tcagcacact 2865241 tttttgtttg tcagtcagct tctggatcgc ttggtagagc tggtaatcct gtacatgctg 2865301 gctcaaatca tcctgcctgt ctaaaaattc ttcaaatgca tcgctacctg tttcggaaga 2865361 aagccgatct cccgcctccg gatgatcaac cgtcagtgga taccgttttt ggtttttgcg 2865421 aacccgctta tcaaaatcaa tagaaaagat gcgaatcatt gaattcatat acttgacgat 2865481 gcggatttct ttataaaatt gcttaaatag ctcgtccaat gatcttgcat ctttttcgtt 2865541 agggctttcc attacgtttt tgaacaaacg gtaatgctga ggattgctca aaaaatgctt 2865601 cacgatggga tgcttcatta tctccttaca ttttgaccgt aaaagacttt gatagtccat 2865661 caaaccgcct ccctactaaa ttaaatgaag gaaagcaaaa aaaagtaaac tactactttc 2865721 cgcctagtgt cttccaaaat actttgcagc agtttacgtt ttatcggttt tcctcactta 2865781 catacatgac tgcagaaaaa gaagggaggt attttcctat ggatcaggtt tttatagagg 2865841 aagtcgtaaa acagatcggc aatttggggt ttcccgcgct gattgcaatg tatctgctga 2865901 cccgattcga aaagaagttt gatcaactaa tagaactaat gacagaactg aaagatcatg 2865961 caaaaaaata atttttcaat cgaagttgac ttttcactgg tttttttcac ttaacaaaac 2866021 agaagggaaa acgaaaggcc tttcaccttc tctttctgct atcacattta aatgtaagga 2866081 ggaaacattt catgaaaaaa caaaatgaca ttccgcagcc aattagagga gacaaaggag 2866141 caacggtaaa aatcccgcgc aatattgaaa gagaccggca aaaccctgat atgctcgttc 2866201 cgcctgaaac cgatcatggc accgtcagca atatgaagtt ttcattctct gatactcata 2866261 accgattaga aaaaggcgga tatgcccggg aagtgacagt acgtgaattg ccgatttcag 2866321 aaaaccttgc atccgtaaat atgcggctga agccaggcgc gattcgcgag cttcactggc 2866381 ataaagaagc tgaatgggct tatatgattt acggaagtgc aagagtcaca attgtagatg 2866441 aaaaagggcg cagctttatt gacgatgtag gtgaaggaga cctttggtac ttcccgtcag 2866501 gcctgccgca ctccatccaa gcgctggagg agggagctga gttcctgctc gtgtttgacg 2866561 atggatcatt ctctgaaaac agcacgttcc agctgacaga ttggctggcc cacactccaa 2866621 aagaagtcat tgctgcgaac ttcggcgtga caaaagaaga gatttccaat ttgcctggca 2866681 aagaaaaata tatatttgaa aaccaacttc ctggcagttt aaaagatgat attgtggaag 2866741 ggccgaatgg cgaagtgcct tatccattta cttaccgcct tcttgaacaa gagccgatcg 2866801 aatctgaggg aggaaaagta tacattgcag attcgacaaa cttcaaagtg tctaaaacca 2866861 tcgcatcagc gctcgtaaca gtagaacccg gcgccatgag agaactgcac tggcacccga 2866921 atacccacga atggcaatac tacatctccg gtaaagctag aatgaccgtt tttgcatctg 2866981 acggccatgc cagaacgttt aattaccaag ccggtgatgt cggatatgta ccatttgcaa 2867041 tgggtcatta cgttgaaaac atcggggatg aaccgcttgt ctttttagaa atcttcaaag 2867101 acgaccatta tgctgatgta tctttaaacc aatggcttgc catgcttcct gaaacatttg 2867161 ttcaagcgca ccttgacttg ggcaaagact ttactgatgt gctttcaaaa gaaaagcacc 2867221 cagtagtgaa aaagaaatgc agtaaataaa agacttgcgg cttgcagaga gcactcgttc 2867281 tctgcaagcc ttcataagga gctgaaccag tgaaacatca aaacccttca aaacgcttat 2867341 tgcggctctc cataaagtac ttgctggccg cagcagcagt ggtgttgacc tattttgctg 2867401 tcatctatat attgttttct ttagcgggaa cgagctaccg ctcagcagct catgtcctgc 2867461 tttttgccgt ggtattcctt gttctcggat tatgctttga accatttgaa cggctgatga 2867521 tacatagctt tacatttttc aagacaggaa aacgtctatt cattctcctt gctggcatcg 2867581 tacagctgct gtttttgtgg atgactgctc atacaacaga ccaattgatc agcgacatct 2867641 ggctgtccac cacagaagaa atgattgtcg cagccgtttt tttgatttta gacaaatgca 2867701 actcggctct tcccagctaa aaaaagaacg cattccaatt ggatgcgttc tttttattca 2867761 tagcgaagcg cgtctacagg ctgaagcttc gaagccttga tagacggaag caagccgaag 2867821 ataatgccga ctgccattga aaagatgagt gctccgacaa cagctggaat ggagacgata 2867881 aaaggcatcg gaaaaatgac cgtcagcagc ttggcgatgc cgaagcccgc cagcacaccg 2867941 agtattccgc caatgcttgt cagcacgaca gcctcggtta aaaattgaaa taaaatcaca 2868001 cgccgcttag caccgagcgc tttcttaatt ccgatttccc tcgtgcgctc cgttacggaa 2868061 acgagcataa tgttcatgac gccgataccg cccaccaaaa gtgaaatact ggcgataccg 2868121 ccaagcagca atgcaaatga ctgattaaag gactccactt cctgcgcgat ctcctgaaga 2868181 tccattacac tgtactctgc tttttccagc tcagcttctg acagtccctg atttaaaaga 2868241 tctgcagcca ttacacccgc ttcttggata tgctcagaag aatcagcctg cacggcaatc 2868301 tgcgttggcg cgtcaaatcc ttcaataagc ggccacactt ttttcggcac gtacaaaacc 2868361 gggttcgcat agtcgccttc aaacatgctt tcctgttgat ttttttcttt aaaaacaccc 2868421 acgaccttaa acggcacacc attcatctca atgcttttat gcagagcttc tccgtctgga 2868481 aacagttcat ctctgacagc ttcattgatc atcactactt ggtgtgtgct gtttaaatcg 2868541 ttttccgtca gctttctccc ttcggttatt cggattggaa acatgtcgaa gtaatcatcg 2868601 tccactccat acacttgggg atacgaaacg ttagttaaat gaaaaacgct cgcgccttct 2868661 gacaagtaat ataaggataa tcctttgacc atcggatctg atttgatcgc ctttactgtt 2868721 tcttccgcta caggcggcgc ggacgcatac gacacctgag ggccgccgct ctcctcttct 2868781 ccgccagacg gctggtagac aacattgatg gcgttgtttc ccatgccgat catactttgc 2868841 tttaactgct cactttggcc cttcagcatt gaaacaatcg cgatgattgc cgctatgccg 2868901 ataatgacgc caagcattgt cagaatcgat cttaatttat gagagaaaat ggattgaaag 2868961 gagattcgaa tatgttcaag catggctgat atcccctctc tcatctaata ccaactctcc 2869021 gtctctgata aaaacggttc tgtcagcttt tttggcgacg tccgggtcgt gggttatcat 2869081 aataatggtc ttgccttccc gatgcagttc agaaaacagt gccaaaattt gttcacttga 2869141 tttggtatca agcgccccgg tcggttcatc agctaaaata aacctcggct gattgacaag 2869201 ggccctcgct atcgccaccc gctgcttttg gccgccggac agcttaggcg gtttgtagga 2869261 gaccctgtct tttaatccga ctttttccag cgcttcatat gcccgttgcc ttctctcttt 2869321 tttcttcact ttattgtaga tcatcggcag ctcgacattt tgcagcgcgg tgagacgcgg 2869381 cagcaaatga aaagtttgaa acacaaaccc gattgattca ttgcgaattt cggctaaagc 2869441 cccgtctttc cctttcaata tatcgatctg gtcaagcgta taggttcctg aggttggcct 2869501 gtccaaacag ccgataatat tcattaacgt tgactttcca gaaccggaag gccccataat 2869561 agctaaaaac tcccccgcct gaacggtcag attgatatgt ttcaagattg gaacttcttc 2869621 ttttcccagc ttgtacgact tcgaaatatt attcagtgtc agcattgact gtaacctgct 2869681 ttccttcctt gaccgcggga tcaggataga tcacataatc ttccggcgtc aggccgctct 2869741 taatttccac catgtcattt tcatcagtct ctccgatttc aacaggctgc ttaaccgctt 2869801 tgtgattctc atcagctttc catacgtacg gttcgccgtc atcctgaatg accatgtcgg 2869861 acggcagctt gatcgtgtcc gcatcagcat tatcactcat cacttcgatg ttgacatgat 2869921 agccgacttc aagaccttta tggctgtcta ataaaatggt gaaaggatag ttagaggact 2869981 ggggattcat ttcttcatca gcaaagcttt ctgattcttc accctcgcct gctcccgctg 2870041 gaagcttgcc gatcgaggtg acctttcctt tccactcgcc ctcaccgcct gttttcagcg 2870101 tgaccctgac tttgctgcct tttttgatcg tgtccattaa cagctcattg atttggcttt 2870161 tgaccagata tttgcctgtc gaaacaatct ggatatacgg gcctgctgcc tggtcgcctg 2870221 ttgcaccgtc agcgatatcc tgattgacgc tttgaacgat tccgtcatgc ttgcttgtaa 2870281 tgacattgga acctttgttt ttcgtcaggc cagccagttc tttttgatgc tgcttcagtt 2870341 caagctggct tgttttcaaa tcgaaattgg tttgatcaag ttcatcttga agctggtttt 2870401 tctcttcttt tcctgcaact ttcagctttt tttccgtttc cgttattgat ttttgcaaac 2870461 ggttgatttg cagatttgtc atttcaattt gcaaattggc ttgctccact tcatcagaat 2870521 gatcctcgcc ctcatactca aaaagcttat cgcccttttt aacctgatcg ccttctttga 2870581 cgtatgtttt tttaatgctg cctttttctg aatctatgta tactttctgc tgtttctcag 2870641 gttcaacctt tccagaaaac gtttggcctg attctgaatc tcctcccatg tataccgcga 2870701 ccgattcagc atagggctcc gatgatacgg caacttggtt catgtgagta aaaaagtaaa 2870761 aaccgccagc gccgatccca gccaatacaa gcacaccggc acatatcgca ccgccaataa 2870821 gccatttttt cttcttggac acaacgatct cctctttctg taaactatgt aatattttcg 2870881 aaacattcta accaatatta tctattaatt caaaaagact tgcaatcctt ttattgaaat 2870941 gacggaatca aatagaaaaa ttgtattttc aaagccgaat aaaaaaaatc ccggcttcaa 2871001 accgggattt tttcatacag taactagctc tttttcattt ttaatcaagt catatgtcaa 2871061 gcatacaggt ttatttgtac ggggatcagt cacgatttcg gcatcaatct gaaatacctg 2871121 cttcaaaatg tctggtgtca tgacctccag agcagttcct tccttgatga ccgtgccttt 2871181 tttgagcgcg atcatataat gagaaaaacg agctgcatgg ttaagatcat gaatgaccat 2871241 taaaatcgtc cgcccttgct ctttgttgag tctgtcaagc agctgcagaa tttcaagctg 2871301 atgtgcaaga tcaagatacg ttgtaggttc atccagcaga agcagttccg tcccttgcgc 2871361 aagcgccatg gcaatccaca cacgttgacg ctgtccgcct gacaatgcct caatcggccg 2871421 ttcagcatat tcagccatgc ctgtttcttc aagcgcccat ttgataatcc ggcggtcttc 2871481 gtcatttaat ctgccgaatc ctgattgatg cggaaacctg ccgtacgaca ccaattcgtg 2871541 cactgttagg ccgctcggcg cttcaggtgt ctgtggaaga atcgccatat cttttgcaat 2871601 gtcctttgta gacattttat gaatcgcttt gccgtttaaa tagacggcac ctgcatgtga 2871661 acgcataatt ctggacattg tttttaaaat cgttgatttc ccgcagccgt tcgggccaat 2871721 taaggtggta attttccctt taggaatcga tatatttaaa tcctctacaa tcaccctgtc 2871781 gccataaccg attccaagct gttccgttga taatgaattc atattcggcc ccctcctcta 2871841 attcgctttc atcaataaat aaataaagta aggcgcacct agcacggaaa tgacaagtcc 2871901 gaccggaatt tctgatggtg ccaatacatt tctcgccagc gtatcagcaa gcaaaaacag 2871961 gaatgagccg atgaaggcgg agaccggtat cagcgtctgg tgacgtggac cggtcagcct 2872021 tctagccaca tgcggcgcga tcaatccgag aaacgcaatg ccccccgcag ctgccacgca 2872081 tgaagcggca agagtgaccg ctgccagaag aagaatccgt ctttcctttt caacagcggt 2872141 gcccagcccg gtcgccaatt ggtctccgag ctgcataatg ttcaaatagc gtgccttata 2872201 taaagtaaac agaagcaaga tcacaatcca agggagaatc gcccagatca tattccagtt 2872261 cgccccccat attgagccgg atatccaaac cgcggcttgc ataaaatcat gagggtccat 2872321 cttgagctga aaaatcagca acagggcgtt gaatccggca ttcaccccta tgccgactaa 2872381 aatcagccga atcggtgtca cgcctttttt ccatgccaga atataaatga gaaacgcagc 2872441 gaggattgct cctgccaaag cactgaacgg cagcataaat gttccgaaaa agctaagatc 2872501 tgaagctgac ccttgaaaaa agtatataaa aagcactaca gcaagtgaac cgccggcgtt 2872561 aattccgaga ataccaggct cggcaagttc attttgagac acgctttgca aaatggctcc 2872621 agctacggag atccctgctc caacaagcaa agaaaggatg atccggggca gcctgaactc 2872681 aaataagaca agttcatcac gcgccgttcc ttggccgaaa aagacctgaa gcgttttaag 2872741 cggtgcaatt ttgataacgc ccaaattgag actgataaaa aagaccacca cgataagcaa 2872801 aaaggtcaca gccattacaa tgagcggttt gtttgttttt gttttcatta cagccctctc 2872861 ctttcacgac gtgccaaata aaagaaaaag ggaacgccga taagagaagt cagcgcgccg 2872921 acaggcgttt caaagggcgc atttacgagt ctggccgcta tgtcagcaaa aacaagcaaa 2872981 acagcaccga gcaccgccga gcaaggaatg atccaccgat aatccacacc gaccaaaaaa 2873041 cgggtaatat gcggaatgat cagcccgata aatgcaatgg tgccggcaat ggaaaccgca 2873101 gctccggtca gaattactac aataagcatg ccaaccagtt tcaccgctga tgtatattgt 2873161 ccaagccctt ttgccagatc gtcaccgaga cttaacactg taacagaccg ggcgatgaaa 2873221 aacgcgagcg ttaaaccgac agcccctgca ataagcaaaa gctggacccc cgaccatttc 2873281 acacccgcta ccccgcctgc gtaccaaaag ctgatatcct gagcgacatc aaagcggatt 2873341 gcaatggcag ttgaaatgcc ggtaaagaaa taagtaactg ccgtacccgc cagagcaagc 2873401 tttacaggcg taagtccgcc ccttgaaaac atgcctatgc ccattaccgt cgatgccccc 2873461 agccccgctc ccgcaaagga ccatagcaca agccccattg cagaaagtcc gggaaaaaag 2873521 gcaaacgcaa tcgaaaccgc aaacgcagag cctgatgtca cacccataat cgaaggctct 2873581 gccaaagggt ttctcgtcat cccctgcatg attgctcccg acactgccaa caatgcgcct 2873641 acaagcgcgg cagccgccgt tctcggaagc cgaagatcat gtataatttg gtgagatgtc 2873701 tttgtcggct gataatgaaa aatggcctcc catacagtgc gcaaatgaat atccgctgca 2873761 cctagggata tggataaaaa tgcgccaagg caaagcaggc atagacctgc gataaggacg 2873821 atgaccgcgc catatgtcct tgacgtccat tggatttctt ctgatgcagt ccgtatattt 2873881 ttatgttgac tcaactgccg tacttccttt ctgttactga taatgattat caattgctgt 2873941 ttcagtatat cacttttttc agctgattta atagagtgtt ttgaacaaaa atgaaaatgc 2874001 atttgcaaaa atatcgtgtc aaccggcact tgcagtggta taatcacaga tgataatgat 2874061 tctctttttc atctatcttt tagaaagaag gtatgagata tgacccatat atacaagaaa 2874121 ctcggagccg cgttttttgc cctgttattg attgcagcgc tggcagcctg cgggaataac 2874181 tcagaaagca aaggttctgc ctctgattca aaaggcgcag aaacctttac atacaaggct 2874241 gaaaacggaa atgtaaaaat cccgaagcat cctaaacggg tggttgtcat ggcagacggc 2874301 tattacggct acttcaaaac actcggcatc aacgttgtag gtgcgcctga gaatgtattt 2874361 aaaaaccctt actacaaagg aaaaaccaac ggcgtcgaaa acatcggaga cggcacttcg 2874421 gttgaaaagg tcattgattt gaaccctgac ctgattatcg tctggacaac acagggcgct 2874481 gatattaaaa agcttgaaaa aattgcgccg actgtcgcag taaaatacga taagctcgac 2874541 aacatcgaac agctgaaaga atttgcaaaa atgacgggaa ctgaagataa agctgaaaaa 2874601 tggctggcca agtgggataa aaaagttgcg gccgctaaaa caaaaatcaa aaaagcggtc 2874661 ggtgacaaaa ccatttccat tatgcaaacg aacggaaaag acatttacgt atttggtaaa 2874721 gactttggaa gaggcggaag catcatttac aaagacctcg gcctgcaggc tacaaagctg 2874781 acaaaagaaa aagccattga ccaggggcca ggttatacaa gtatttcatt agagaagctc 2874841 cctgacttcg ccggagatta cattttcgcg ggcccatggc aatcaggcgg tgatgatggc 2874901 ggcgtttttg aaagctccat ttggaagaac ctgaatgccg ttaaaaatgg ccatgtatac 2874961 aagatggatc cgatcggatt ctatttcaca gacccgattt cattagaagg acaactggag 2875021 tttattacgg aaagcttgac taaataaaca aaagagccgc ctgcccgcgg ctcttttgct 2875081 tatttataag gaacggctca atttgaatca tatcggatat tttctttgag ccattcatat 2875141 taagctgcat cctcatcacg atcagttttt ttatgctgga gagactgaaa aacgtttttt 2875201 gcatatttaa cgaacggatt cctaacagga gaaattgtga ttttataaaa aagacacctg 2875261 agcaaatcag gtgtcttttc attatgcttg tttttctttc tggaacttgt tactcacaaa 2875321 tggataaacg attaagccga caaagaataa accgatgccg agtataaatg tcgttaaatc 2875381 tgctgtgcct gttacgataa caaacacgga gtatgcacac gccagtatcg cgatcaatcc 2875441 gtctcttaca cgggagcctt tcagctggtc atacgtttca cctttgatga ctaccttcaa 2875501 gctgtagatt gcagatacca gatacggaat taaatatgcg agtgtagccg ctgtcgttaa 2875561 aaatgtaaat gcgtcactta ttgtccggga aataaccgag aaaatgaaga cctgtgacat 2875621 gacgtttgta ataatgagtg caatgaccgg acttcccttt ttattcgttt ttgcaaaaaa 2875681 tgccgggaaa tctcctgctt tagcggcttg gtatggcacc tcagagccaa gcaaaatcca 2875741 gccgagcatc gttccgaata aacaaaggat agccaaaagc gccataatca cgcttcccgc 2875801 gtttccaaca atcgcataga gtacatcaac aaatggtttt tcagagccga caagcttatc 2875861 atgcggcaga acacccatcg taattaaagt cacaataata tatatgctca aggcaatcag 2875921 caagccggta attgtcgcac gtttcacatc acgctgagag cgcgcacggc cggacaggat 2875981 caccgcggat tcaattccga caaacgccca cagtgtagaa atcgcagcgt tatgaacctg 2876041 gccaccaatt ccaatgcttg tgccgttttc tccttgaacc gggaaataaa aatgaccgaa 2876101 taatgacgtt tgaaacacaa acaaaccggc aacgataaag aagacaaaac ctaatacttt 2876161 agaaagcgtt gtgacaaagt ttaatttact tgcgccgtta atgctggcaa caagaatcgc 2876221 gtgcgttccc cataacaaga tcgtacatac ggcaaacgtc agtaattggc cgagtgtcac 2876281 ctcttgcccg ccgatcgaaa acatctcacg tttatcaacc aagatcggga agaacgaagt 2876341 caagtaaccg gcgagacttg tgatgatcgc cacgttactg atccagctcg ccacccagta 2876401 gccccacacc attgtgaaac cggcagcgtt gccttttttc gggtcagaaa acagcgctct 2876461 tgcataactt tgcggtcccg ctgtcagttc aggcttgcga atggacaagt gtccgaacac 2876521 aagtgcaatc atcagcacgc cggcacctgt caaaagccag gcggacgtag ctccaaacgg 2876581 actcgcaatt gaagcaagcg agctcggcaa ggagaaaatt cctgatccaa ccatatttcc 2876641 aacgacaaac gccgttaata accaaaaacc ccattttttt gtctgttcca ttccagtacc 2876701 tccatgattc tttgtacgga ccagaccccg agatcatata aacgcaaaaa aagcctgaac 2876761 aaaagtccat gcttaaagaa acacacaccc ttgatctccg gatagccctc cgcgaaaaag 2876821 cacgcggcag tcctgcactt attcagatac agtcccagca tagagaagga tcggctttct 2876881 ccacacttcg gcgctgatgc cttttacaca tgtttaacag cccctgtcag cctagcatgt 2876941 gtgactcatc atccgcgcaa cctctacctc actgagaaag agtgaggatt taattattca 2877001 gttactccca gaaggttatc aaagaaagga tgatctgtca aagggaacag atggaaaata 2877061 cggatagagc caagccctat ccgcatgtgg ttatcgatta tttttctttt tttgcacagc 2877121 ttcttgaagc ggatcatctt ttagagctga accagcatct tcaagagctc cttggattac 2877181 gtttttttct ttttcggaac gttttccttt atctttatta aagaaaccca ttcgtatcac 2877241 ctcttttaaa aaataggtac atgtttaaga tgcctttttc ctgaaaaatt atgcgggata 2877301 ttttttatcg tccaaagtcc tgttgatcaa acatacattc tcttgatata tttgtaattc 2877361 agagattttt tgcaaaagat aaaaggagaa gcggcaaatg acaggaaaaa cacacatcat 2877421 gggaggcatc gcttcttgta cggcagcggc ttattattat ggatttgatc cagtgcttat 2877481 ggctgcgtca ggcgcggttg gagcattaat acccgatatc tgccacacac aaagcaaaat 2877541 cgggagaaaa tttcctattt tatcgaaagt ggtcagctcc gtttttggcc atcgcacctt 2877601 tacacacagc ctgctgttta tgctcatcat gttttttatc acttctacat acattccaga 2877661 taaaaacata tcagccggcc tgatgatcgg aatggcgagc cacttgattc ttgacgcttg 2877721 gacggtgaac ggaatcaaat tattattccc ttccacgatc cgcgttcggc ttccattata 2877781 tatgaagaca ggcagttttt ctgagcagct cgtgctagcc ggcctgaccc ttgcttcatg 2877841 ttactacttt tatatgctgt ttcatggccg catgttttaa acatgagtgc tgagacttgt 2877901 ctgaaccggc tgtttttagt aggttttact taagaagcat ttcatgcaga tgatcaagaa 2877961 aacgtgagga gtcatattga tgaaaggaac cttttttcac aatcagcggt ttttatgttt 2878021 ttcgatctta tttatgtgga tcaaaacgta tgtgatatat aaactcggct ttgatttgca 2878081 aatcgatact ctgttggagg agctaatgct gctggtcaac ccgctcagct ttattcttcc 2878141 tttattcggg atcggcctgt ttctaaaaga aaacaagcag cgggcctttt tgctgattgc 2878201 caatttggtt ctgactgtta tcttgatctc taatacgatt ttttacggct tttatatcga 2878261 ttttattacc atcccggttt tatttcaggc cagcaacatg agcgatatgg gcagcagtgt 2878321 aaaagaactg ttccatcctc tgtttatcgc cctgtttgtg gatttggttt ttctgctgtt 2878381 gttcgccaga aaaaccaaac acccacagac aaaagccgct ccccacacga tcaaacggta 2878441 ctatgcagct tcctgcggaa tgcttttatg cacactggca cttgcagaag tacagcagcc 2878501 gaagcttttg gcacattctt ttgaccggga aatgctagtc aaaagcatcg gcctgtttca 2878561 gttccatatt tacgatacaa tttctcagac tgttaatatc agcgcgaaag cttttgccga 2878621 tgaagacagt ataactgcca ttaaaaacta cacagaggct gattacagca agcctgatca 2878681 aagcaaattc ggtcttgcaa aggggcgcaa tgtcatcttt gtaacacttg agtcgaccca 2878741 aagctttgtt ctgaatgaaa aagtaaatgg aaaagaaatt accccattta tgaatgatct 2878801 cataaaaaaa agctattcct ttgatcattt ctatcagcaa acagaacaag gcaaaacatc 2878861 agattcagaa tttatcgtcg ctaactcact gtatccctcc cttagcggcg ccgtcttttt 2878921 cacgaaaagc gaccatcaat ttcatacgat gtataaatcg ctgaagcagc acgattatta 2878981 ttcagccgtc tttcacgcta accataaaac attttggaac agagatgtca tgtacgatac 2879041 atttggcatt gaccgctttt ttgatgttga tgattttcat gtcactcccg ggacatcgac 2879101 aagctggggc ttaaaagaca aagaattttt agagcagtcc gccaaaaagc tgaaaagcct 2879161 accgcagccg ttctacagca gttttatcac gttaacgaat cattttccgt ttgagattga 2879221 tgaaaaggat cagctgatag atgaattcga ttcaagcagt gatctgttaa accgctatgt 2879281 gaccacggtt cgctatgagg atgaagcatt gaagcatttt atcaaaaaac tgaaggacga 2879341 aggcttatac gaaaattcga tgatcgtatt tatgggagat cattacggca tttctgaagc 2879401 ccataacgag gcaatggctg agtttttagg gaaagacgaa atcacaccgt atgacaacgt 2879461 tcagctccag cgggtgccgt ttatcataca tatcccggga atcaccgatc aacagccgga 2879521 aaccatccct gatgccgggg gacaggtcga cgtcaggccg acgctgatgc atttgctcgg 2879581 cgttgagaca aaaggcgata tccaattcgg caatgatttg ctgtcgggcg accgcacccc 2879641 attcgccgtt ctgcgaaacg gcagctttat tacgaacgat tatgtataca caaagaacac 2879701 gtgctatagc caaaaaacag gtgaagtgct ggaagatcag gatgcgtgcc tcccttacaa 2879761 ggagaaagca aacgaagaac tgtctctctc tgataaaatt ttaaatggtg acctgctcag 2879821 gttttccgaa tgaaaaaatc cctctatcaa gagggatttt ttacgtttcc aatatcacct 2879881 tgccagtcag cttcgtttca tagccgttta aatgagacag attcgccttg tagtcctcag 2879941 aattcaaaat ctccttcacg gctttgagca actgctcatt ttttttcaaa acaacgatat 2880001 catattgttc gtcgatgagc gggataaaat caacactgcc catatgtgcc gcgtgctgtg 2880061 ccccgattcc cgcgtcagcc tgtccgcttg aaacttgtga agcggcagcg taatgatcag 2880121 tcacgatatc gccatatccc actacatcag ccggattcac accaagcaag ccaagctgtt 2880181 catcaaggag cacccttgcg ccagaaccct tttccctgtt gatgatccgg atatcggctc 2880241 ttttcaagtc tttccagcct tgaatgtttt tcggattccc tttttgcaca tacagtcctg 2880301 ctttgcggag aacgacattg atgagacaaa acggttcacc tgtcaaaatc cgttttacat 2880361 aaggcgcgtt atactggccc gtttctgcat cgtacaaatg gaggctgaca atgtcacact 2880421 tgccttgata catatcaatc aggctgttta agcttccttt gtatttacgg agcggcgtct 2880481 cctgaatggc attctccaaa tgcttgctga ggatatccat cgaaatgtcc tgtccgctga 2880541 tcatgacatt tggtctgccg tccggctcag cctcctgcac ctgtttcggc gcttcttttg 2880601 cagcgatggg ctgagacatt ctcatattcg ttttatattg ctttaaatct tcttcatcca 2880661 cacgcatctg ccttccgaca cggtaagcag gcagcacgcc ttttttaatc aagtcataaa 2880721 cggtcagctt tgataccttc agcagacctg caacttcttc tatcgtatag gaagaggttt 2880781 cattcatcat catcactctc ctattttatt ataccttttc gccgaatgta aaaaaaccca 2880841 cataaaccaa acataatcag ttataattag ttatatctaa tgataagggg tgcaatcatg 2880901 tttaagaagt attctatttt catcgcagcc ttaactgctt ttctgcttgt agcaggctgt 2880961 tcttcaaacc agtcttcaac ggacagcgag aaaaaagtaa cgttaaccat ctcagctgcc 2881021 gccagcgcgc aggatgcact tgaggaaatc caaaaaaatt atgaaaaaga tcatcaacat 2881081 ataaccatcc aagataacta tggctcatcc ggcgccttgc aaaaacagat ttctcaagga 2881141 gcaggagcag atctgttctt ctcagctgct gaggataaat ttaaaaagct ggtggatgat 2881201 ggagatatcg caaaaaaaga cagcactgaa ttagtcggta atgaaattgt gctggtcgta 2881261 ccgaaaaacg gagattcacc tgtgacaagc ttcagcaatc tggctgaatc agaaaaaatc 2881321 gctcttggca ctccggaatc cgtaccggca ggagcttatg ggaaagaatc actgacaaag 2881381 ctgtctttat gggacaaagt gaaggataaa attgtgtatg gaaaagacgt tcgccaagtt 2881441 ctttcttatg ttgaaaccgg caatgtagac gcaggtgttg tttataaaac agatgcccta 2881501 gtctcgaaaa aggtcaacat tgttgacgag gcaaaagcag atacacacag cccaattgtc 2881561 tatccgttag gaatcgtaaa agatacaaaa caccgtaagg aagcgaagga attttacgaa 2881621 tacctgcaat ctgatgaagc aatgaaagta tttgagaaat atggctttac tgccgagtag 2881681 cataagcgct tcagaatttt tcacacccgt tgtgctttcc tttcaggtgg cggcagttgc 2881741 cggaattgtt gtcattattc tcggaacact tgctggagca tggatgtcac gggcatcatt 2881801 tttcggaaaa acggcactcg aaacatgttt tatgcttccg ctcgttcttc cgcctactgt 2881861 tgtcggtttt attctgatcg tcattttcgg aaagcacagc ttcatcggac aagccatcga 2881921 gtggattttc cagcagcctg tcattttcac ctggtgggcc gctgtgatcg cctcggctgt 2881981 tgtagccttt ccgcttatgt atcaatcagc caaaaccgga tttgctgaca ttgatcccga 2882041 tatacaaggt gcggcaatgg tagacggcgc tagcagatgg aaagtgttta tccatatctc 2882101 cgtcccgctt gcctatcctt cgttactgac cggaagcatc cttagccttg cgcgggcgct 2882161 cggagaattt ggcgcaacac tcatgtttgc aggaaacatc cccggtgtta cgcaaacact 2882221 gccgacggcg atatatgtcg cattggattc cggcaacaat acccttgctt gggcgtgggt 2882281 cgtctgtatt gttgtcattt cctttttgat gctgtttttc attcaacaga aaaaaacgca 2882341 ctaaaaaaac tccccataac ggggagtttt ttgattaaaa cagaagctca tcaggatttg 2882401 gaccgacacg ctcatcttta tttaatgcgt caattttgtc catgtcttct tgagacaatt 2882461 cgaaatcaaa aatatcagcg ttttcgatga tacggtgttc tttaatggat tttggaatgg 2882521 ttacaactcc atgctgcaga tcccagcgca aaatcacttg agccacagat ttattgtgtt 2882581 tttcagcaat ctgtgtcagt acttcgttat ccaaaagctg tccctgcatg agcggagacc 2882641 acgcttccag ctgaatgcct tgccctttgc agtaatctct taattctttt tgcgtcaagc 2882701 gagggtgaaa ttcaacttgg ttcaccatcg gtttgatttc agcatctttc aacagctctt 2882761 ctaaatgatg aacttggaaa ttgctgacgc cgatcgcgcg aattttgccg tctttgtaca 2882821 gcttttcaag cgcgcgccat gtatctttat atttatcttt gccaggccaa tggatcaaat 2882881 ataaatctaa gtaatcaagc tgcagtcttt ctaggctttt ttcaaaggca gcaagcgttg 2882941 tttcatagcc ttgatcttca ttccacactt ttgatgtgat gaagagctct tctcttgcca 2883001 caccggattc tttaatcccg atgccaacgc cttcttcatt tttgtagatc gctgctgtat 2883061 caatactgcg atagccattt ttaattgccg ctttcactga ttcagtcgct tcattaccat 2883121 tttctacttt aaaaacgccc agaccgaacc aaggcatttc aactccgtta tgtaacttta 2883181 cagtatcttt taaacttgtt ggcacttgaa cctccaccct ttcactgaaa tgtaagcgtc 2883241 tatattatct cacattcctc tcagccgata ccaataatac gcttaagacc ctctttttgc 2883301 ttcttttttc acagcacagg caaatccaaa cactattttt ttcctatttt aacaatattg 2883361 agattacaaa tacattgagc agggtatgcg tgtagtgtaa ccaaatgaaa acaaaggagg 2883421 aaacaacttg aaacgtattc gtatcccaat gacacttgct cttggtgccg ctttgacaat 2883481 tgcccctttg tcctttgctt ccgctgaaga aaatcctgct ccgaagatgt cgcagacaac 2883541 tactgctgga acaactgccg ctgatgtagg tttaaacgtc aacctggatg tacttggaat 2883601 tgccaaccag atcgctgatg ccatcaaatc cgcacagaat agggatggct ttgtgaaaaa 2883661 cctcatggag tcttccttct acgcgtccgg ccaaaaatat aacgtcatgg tctttaattt 2883721 aagccaggaa tatgaagatc atttgaacgg tgtgcaattt tacggctcag ccgtttacga 2883781 cggcattacg tatggcattt gggtatttga agatggaacc tttacaaaca aaggcgatgg 2883841 cggctggatc aactgggcct tcagaggctg gttcgaccgg gatggcagca ctgtcgcatt 2883901 tcatcgccct taatataaaa aaagctggcg ctctaacgcc agcttttttt ctgcatttat 2883961 tcgccgcctt caagcatggc ggcttcgaca tcattaatgt attggcgaag ctcatgggag 2884021 atgtcccggg aaatttccct ctcttcgaag agcgtttgaa tttcatttct gatcgcctgc 2884081 acagccttca gcttcacttc cagcttctga ttttcaaaat gggcacttga ttttaactca 2884141 tgatggctgt gctccagcct gaaaattaac tgcttataga atgtaatgac agataaaaac 2884201 acttctttat gctcatccgt cttatgtttt tccagatatt ctatcgctgc ttttgccgtt 2884261 ttcactcttg ttgcccgtat caatcccgct tcatttaaaa tcgacatctc cggcttttta 2884321 tgttcaccga agaaaatcca atacatcagc ctcttgagcc ttgtttttga taacccgact 2884381 ttaaacgggt tggcatacaa aatttccaac tcgttaaatc gttcttgcag cacatttgct 2884441 gtttcttccg ggatgtctcc ccgctccagc attttcatca gcgcctcttg ctcagcctta 2884501 accccctgcg cacggacttt tcgctcgtgc ttcttaatgc gattagatga tgtatactgc 2884561 tgaaaacgaa gatttttcat tttctcattg tattcagcta tcaccgcaag agaggccgtt 2884621 ttgtttgtct cattcatgtc ctctttaatc gtttgaaggg ctgttttgat caacttgcgt 2884681 ctcgccgtca gcagcttctt atttcgttcc tcgtcctctt cttctttttc agtcagaatt 2884741 ggcagcacaa cggtggcaat gacaagcgtg cataaaatga cgccggctgc taaaaagaga 2884801 atcagatttc tttccggaaa cggcgtaccg tcctccagga aatacggaat ggaaaaagaa 2884861 cctgcaagcg ttactgctcc acgcacaccg gaaatcgaaa ttaacagcgt cgaacgaaga 2884921 cccggtttat agatgttctg atctttatta aagaaccatt tgccgttcca gaagaacagc 2884981 acccacagga atctaaggag cattaatgta aatgtgatga ctaggatata gccgatcacc 2885041 ttcatgttgc tgatggcagt gtcgttaaag ataacagaaa taacatcagg gatttgcgtg 2885101 ccgagaataa cgaagaccag gccgttcaaa ataaataaaa taatgttcca cgtacttgag 2885161 gagacgattt gcagcttgat catcgttgat tccagacgat cctgttcaac cgcatgggta 2885221 ataccgccag ctacaacagc taaaatgccc gaaacgccga tttcttcagc tgccaaataa 2885281 atcacaaacg gcgtcagaat ttgaatcagc atatgcatcg tgacatcctg catgccaagg 2885341 cggcgcagaa ataggcgaaa acgaataatc aaaaatgaaa tgacaacccc gcacagcaag 2885401 cctccgagag aaataaagac aaagctgaca gccgcttgtg ctaatgaaaa tgcaccagtc 2885461 actgccgctg caatcgcaaa cttaaaggcc accagacctg atgcatcatt catcagcccc 2885521 tcaccttcca gcaggcgaag aatccctttt ggcattttca ctcttcctga taatgcgctg 2885581 acagcgacga catcagtcgg tgaaagaatg gccgcaagtc caaaggccgc tgccagcgga 2885641 atagcaggaa tcatccagtg aatcgtgtag ccgcctacaa tcacagtcgc aaatacaagg 2885701 ccgagtgcaa gcaataaaat cggagccctt aaattccaaa gctctgcccg cggtgtcctc 2885761 tttccatcat taaatagcag aggcgcgata aaaagaacaa aaaacaattc ggtgtttaat 2885821 tcaaaatgaa gtccctgtgg aaatgaggcg gcaagaatcc caagagccac ttgaatcagc 2885881 ggcaccggaa taaacggaat aaaccggttc acgatattag aaatcgcaat aatcgttaat 2885941 aatacgagca caactaaaaa tatgtccaaa tgcatgacct ccttcgtctg ttgtgtgtcg 2886001 gcatgatgag ccaaaaaatc tgtttgtcta aaagcccttg agctagggtg gccttgcatc 2886061 cgctatgtgg tttcgcagga gttctctcca cacttgtctt cttttatagt acccttttta 2886121 gggtattttt tctcatgata tgctcacagt gaactttttt gcagaagagc aaattataga 2886181 aaaaagagac aggaagctac tccctgtctc tcgtctttct ttctcaatca tgaaaattcg 2886241 taccgtcagt tgttgcttta ataatgcccg cgcgaatgac aaagtcaccg aaatgctcgc 2886301 cttcctcgcg ttctttcgca tagcgggaaa gaaggatgcg cagctcgctt aaaatgtctg 2886361 cttcaccgat gttttcacgg tacattttgc ttaaacggct tccgtcaaac gcagcgccaa 2886421 gatacatatt atatttgccc ggcgcctttc cgataaatcc gatctcaccg agtgcatgac 2886481 gtgcacagcc gttcgggcat cctgtcatgc gaatggtgat ttcctgatca cgaaggccgt 2886541 tttcgtcaat aatctcttca atcttatcta acagggtcgg caaataacgt tctgcttcag 2886601 ccattgccaa tccgcaggtc ggaagagcga cgcacgccat cgagctgcgg cgaagcgctg 2886661 aatagtgctt gccgtcagtt agtccgtact gttcaattaa agcactgatt tcttcttttt 2886721 tatcgcttga aacgttcgca atcattaagt tctgattggc tgtcagccgg aactcacctg 2886781 tatgaacttt ggcgatttcc cgcaagccag tcatcagctt ataatcatcg taatccgtta 2886841 tacggccgcc ttcgacaaac agcgtgaaat gccatttatc ctcgatgcct tccacccagc 2886901 catagcggtc gccgttatga tcgaaatgat acggcttcgc ttcttccagg ctccagccga 2886961 gacggttttc caattcttct tttacgtttt ctaaaccgag gcggtcaact gtgtatttga 2887021 accgcgcatt tttacggaca gaacggttgc cgtaatcacg ctgaatcgta atcgtttttt 2887081 cagcaacgtc atacatttgc tcaggccggc agaaaccgat caccttggct aattgcggat 2887141 atgtcgcagt atcgccatgc gtcattccca taccgccgcc gattgccacg ttaaaaccga 2887201 tcagcttgcc atcctcgaca atcgcaatga atccgagatc ttgtgaaaag acgtcaatat 2887261 cattagacgg cggaacggca ataccgattt taaacttccg cggcagatag agcggtccgt 2887321 acattggctc gacttcttcc tccggcgtgc cggcaactct ttcctcatca agccaaattt 2887381 catgatatgc tctcgtccgc ggcagcagat catcacttaa ttttttagac cactcgtata 2887441 cctctgagtg gatttcagat tgataagggt ttgatgcaca catgacgtta cggtttacgt 2887501 ctccgcaggc tgcgatcgta tccaaaagtg ctgagtggat cgtctgaatg gttttcttca 2887561 tgttccattt cagaattccg tgcatttgga atgtttcacg tgtcgtcaat tttaatgtgc 2887621 cgttcccgta tttctgggac aggtcatcca tgacaagcca ttgttcaggc gtcgagacgc 2887681 cccctggcat acgcacgcgc agcatgaact gatatgcggg ctcaagcttc tgcttttggc 2887741 gttcatttcg gaggtcgcgg tcatcctgca aataactgcc gtggtgtttc atcaggcggt 2887801 tatcatcatc cggaattccc gcactgattc gatcgagcat cacttctttc agcgtgccgc 2887861 gcaaataatc actttctttt ttaatgcgtt caacatcact tggagagccg tccggtgctt 2887921 ttagaatttt ggtcaccatg ttgaaaaact cctttcaagt caaatcaata tacatcacgc 2887981 tgatagcgtt tttgctgctg catatcggca agataagcct ccgcctcttc gcggctcata 2888041 ttgccttctt tttcgataat ttcaagcaat gtgttatgga cgtcatgcgc catgtgcttt 2888101 tcatctccgc aaatgtaaac agccgctcct tcttgaagcc attcaaacaa ttctgcgcta 2888161 tgttcaagca tgcggtgctg cacatatact ttttcttccg tatcacgtga gaacgccaca 2888221 tccatttttg tcagcacacc gtctttgagc caattctgcc actctgtctg gtaaaggaaa 2888281 tccgtgacaa agtgctgatc gccaaagaac atccatgcct ttccttccgc tcccgtctcc 2888341 tcacgctcct gcataaacga acggaaaggt gcgacgcctg tcccagggcc caccatgata 2888401 atcggtgttt cagggtcttt cggaagctta aagttttgat tgtgctgtac ataaaccggc 2888461 agtgtgtctc ccggctgcag tcgttccgcg cacaaaatcg agcagacgcc ttttcgttca 2888521 cggccgtgcg catcgtagcg gactgcgccg attgttaagt gcacttcatc cggatttgcg 2888581 gataaactgc ttgcaatcga ataaaggcgg gcaggcattt ttcgcaaaat cgagacaaac 2888641 tcctgcgcag atacactaaa tgggccatag tcacggacga gatcaagcaa atcgcgccct 2888701 tcaatatagg cttttacatt ctcctcattt cccggggcta aaagctctct aagctcatcg 2888761 ttccctgtca gctgggctgc ctgttcaaga agcggttttg tgagaacggt aatctcatag 2888821 tgagaaatca gcgcttcttt cagcggtcgg acatcacctt gcttattaag cgtcacaatt 2888881 tcttccgggt cccaattcat ttccttaagg agcagctcga caagttccgg atcgttttcc 2888941 ggatagacgc cgaggctgtc accaggctcg taagtcaggc cagatccttc aagagacagc 2889001 tccacatggc gtgtttcttt atttgatcct ctgccgttta aatttaaatt ttctaacact 2889061 tcagcccgaa acgggtttgt tctggaatac gaagactcac cggtttgtga cgcagccgcc 2889121 ggcgcaggcg cggcgcttcc gcccccagct tcatttaatc ctttcaatac accctcaagc 2889181 cattcggctg ccggttcatc atagtcaaga tcgcaatcaa cgcgcggaga aatccgtttt 2889241 ccgccgagtt cttctaagcg ttgatcaaat tctttccctg tctggcagaa aaattcgtac 2889301 gaactgtcac caagcgccaa aacggaaaag cgcaggtctt caagcttagg cgcccgtctt 2889361 ccgtgcagaa attcatgaaa cgacagcgcg ttatcaggcg gctcgccttc tccatgcgta 2889421 ctgacgacga ttaaaagatt ggttaccttc ttcagctgat tcggcttaaa atcgctcatg 2889481 gatgagacgg tcacttgaaa accgctctgt tcaagctgct tgccggcatt ttctgcaagc 2889541 ccctgtgcgt ttcccgtctg tgaaccataa agaacggtca cttcttttga aacggccggt 2889601 gccggtgctt ccgctgacac agctgccgcc ggcgtacccg cagcttcttg ggcggaaaca 2889661 gattgagcgg ataaatatcc gctcagccag attttctggg attcggtcaa ggtcggcaga 2889721 aggcggttaa ggagctctgc ctgctcctga ttaaacggac tgttcattac ctgaagttgc 2889781 aacgtatcca cctcacaaag ttataaactg atcgaaaatt gcatctaatt gaactttacc 2889841 ggaatactag gcttaagtaa aatatattta catgatgata actattaaga atcctaatga 2889901 taaaacggct atgcttcatg taaatagaaa aaagagaagg actcccttct cttcattcag 2889961 caatctgata taagtgaggc ggcacagcgg ttacaaacgg actggcttca cctgtataaa 2890021 ataccgccag catgtgcatc gcacgggtgc acgcagtata taaaagcctg cggtcgtgct 2890081 ctgtatgata gtgttcttca gatgcatcat agacaagcac tgcgtcaaat tcaattccct 2890141 tcgctaaata caccggaatc acgcaaacac ccttttgaaa tggttgattt tctttatgaa 2890201 tcaggcgaac atctgtatat tcactcatgt gggcgtgcgc ctgtatgcat tgatgcgcag 2890261 tcttgcagat gacggctatt gtttcgtgcc cttttttctt gagccggcca atttcttgcg 2890321 cgagcttttg gcaaaggctc tcatgtcctt cagttttgac aacgagcggc atttccccgc 2890381 ttctattaaa cggctcaata tccgctccat cttgaagcat cgctttggta aactcgacaa 2890441 tctgccttgt tgatctgtat gttctcttta aacgaacata ctcagcaggc tcatcctcaa 2890501 agcacgcatc catacgctga tccccgttta tggtatgcgc gtagatggac tgattgatat 2890561 caccgagcac tgtcatgctg gcagccggaa aaatgcttct catgtaagcc atctgaaacg 2890621 gtgaatagtc ctgggcttcg tcaataaata gatgtttgat tttcgtattt ttctttctgc 2890681 cctcaatcag atcctgcata taaagaaacg gtgccgcgtc ctcatagagc aatttattat 2890741 ccgtaaatgc cgaacgggtc agctcaccta tcgcatccat cttctcatgt tgaaattttc 2890801 ctccccagcc agaaaacaat tgcaaataaa gttgtgtaac atcaagaaat gcaaggagcc 2890861 tgactgcctg tttgagcggt ttgaaagctt ttttcacaat gatggcggca agcagctgct 2890921 gctctctttg ataatcgtta aacgtactct cgctgaaccg tttcctttcc tgcagttttt 2890981 tgtacacgtc caagtagtcc tctttgtcaa gcagctcagc ttcatgaaca acccaatcct 2891041 ttcgccgttc ctttttctca agcttgttaa gctcactcag cagccacttc gcggtttgct 2891101 ccatccgatt cggaatggag tgattttgat ccaatgagta aaaataggat tgaatttgct 2891161 cctttgtgat cagcttttgt ccgcggaata taatattttt aaaaatcatc ccttcagagg 2891221 aaagccgtgt gacgtattca ttaatgaatt gctgaaagga taaacccgcc ttccatgtga 2891281 ttcctgcaag ccttgttgga aaatcgcctc cctttgtttc ggtcaggcaa tattcgagct 2891341 gatcaaaggg gctttcacat ttgaacttgc ggccaagacg atgctcgata tattcctgaa 2891401 acgtcgcctg ctccatattc tcttctccta actccggcaa aacagaggag acatagctgt 2891461 taaataagaa gttgggtgaa aacaaaacga tttgtccggc atcaatgaca ccgcggtgcc 2891521 tgtataacaa ataagcgaca cgctgaagcg cagccgatgt tttcccgctg ccagccgctc 2891581 cctgcacgat caggatcttg cttttttcat tacggataat ctgattttgt tctttctgaa 2891641 tcgtagacac gatgtttttc atttgggtat cagagtgatg gcttaatacc tcttgcagca 2891701 tttcatcgcc aatcgtcata tcggtattaa acatcgcctt gagagtgccg tttttgatca 2891761 taaactggcg tttcagcacc atttcccctt ctatcgtttc accgggcacc tcgtactccg 2891821 cttttcctgg ggaataattg tagtacaaac ttgatatcgg cgccctccag tcatagatca 2891881 gaaagtgttc ctccttctca tccaaacagg aagctaaacc gatataaatt cgctctgcct 2891941 gctcctcgcc gttttcaata aaatcaatcc ggccgaaata aggcgatttt ttcaattgat 2892001 gaattcgttt gagctgctga tccatgcgcc gatgattgtg ttcccgatca gacagcagct 2892061 ctgcctgctg cttaatgcta gccatcgttt caatcgcttc atgggcatca tcaaaattaa 2892121 ccttaacatc ctcccaaaag ctttttctta atccgatgat atcatgcttc aacccgcccg 2892181 cagacgtttc cagaaaccgc tctttttttt cgagctcctt cagcacctca tctattctcg 2892241 actgctcttc cttccattcc ttatcctgct gattcatgaa cggcacctcc agaaaatagt 2892301 tgacaaacat agatgaaata ctgtaaaata taattggata catatattaa atatatgatg 2892361 caaactggca aatacaattt ataatagcac attcacccaa taccaatcaa ggtttgggtt 2892421 atttatatta tgcagaaaaa aaccgatttc acttcgaaat cggttttttt gctattaatt 2892481 atctaagcga aaagaacggt ttggcagctt ccaattaaac atataggaac aaacccggca 2892541 aacaacgagc acgaaaaaca gaacgtataa gccgaacgag ttccccagcc agcccaagcc 2892601 gacgattaaa ccgccgagcg ccgcccatac cgcatagatt tccgctttca gcacaagcgg 2892661 tttgcgcccg gcaagaaggt cgcggatgat cccgcccccg cttcccgtca gcaccgcagc 2892721 cacgatcacg gcactaagcg gatggcccat tttgacggca tacagtgcgc cttggatagc 2892781 aaaggcagcg aggccgatcg catctgataa attgccccac ttattccaat gcttcagcag 2892841 cagcttcgga aacagaaaca caattgtaat agataaaagc gcgatttgaa agtacgctcc 2892901 ctgctcccat agcgctgaca ccggaacacc gatcagcaaa ttgcggatcg ctcctcctcc 2892961 aaaagctgtg acaatcccta atatataaac tcctaaaata tcatattcct cttccatcgc 2893021 aacaattgcg ccgctgactg caaacgcaat gatgccaatc acactaagca gctcccaagc 2893081 cattctgatg actccctttt atgtttgtta aattttctga cgacctctag attttataat 2893141 cgctccagcg taaaatcaat aacattttca tgagaaaaaa agataaattt agagggaata 2893201 cggctattgc tgatggacat gagtttgcga aattaaaaaa gcgcccggca tacgcgggcg 2893261 ctttttttgt tattcagatt tttcgccttt cagcaggcac ataaaaatga taatcaggat 2893321 aaaagcaatc agggccagga atggaatcgt aataaaacca aaccagttaa tatattggcc 2893381 cgagcacggc acgccgctga cacatggctt aatgccgcta aagccgggca ctttttgctc 2893441 taagtaatgc atgatcgaaa tgaatgcccc aataatcgcc atcgggagca catatttttt 2893501 cactcgtgtg tccccttgaa aggtggcgat gcctaaaatc aggacgagcg gatacatgag 2893561 gatacgctgg taccagcaca gttcacatgg aataaacttt ctgatttcac tgaaatacag 2893621 gctgcccagc atagcgataa gagccacaac ccaggaagca tataaaaata cgattctatt 2893681 tttcatattg ttacttccct ttcagctctt tttctattgt ctctttgatt tcatcataat 2893741 ccgcaaaatt tttgatcact ttatcattga cgtaaatcgt cggtgttgcc tgtatgttca 2893801 ttttttgatt aaggtcagaa tccttttcca cttgagaagc gaatgtttcc ttatcaagat 2893861 tttccttgag cgtctcaggt tttatctttg tggtgctttt tgcaagatca ccaaggaggc 2893921 ctggggttac ccattcctgt tccgtatccg gctgtttttc gaacagcttt tcatggaaat 2893981 cccagaaaga gtcagggtct tccttccata cttcttcaga tgcaagagcc gctaaccttg 2894041 aaccttttcc atggaacatg acgttcacga aagaaaattt cacatcgccc ttatcaataa 2894101 agtctttttg tatttttgga aagatgtcac tgttaaacac cttgcaagac ggacatttgt 2894161 aatctccgaa ttctactaca gttaccggtg catcgtcctt gccaagcaca ggctgccctt 2894221 tgatagacgg ctgtccggac accgcatcat tgccttgttc cgttttgtta ttaatgatga 2894281 caatggctgc tagcaataca acaaccacaa ccgtaaggat gaccgcgaat ttcgcagaag 2894341 actgctgttt ctttttcact ccgacacctc atcgttttaa aattaaaaaa gaagcggatc 2894401 gcaattgacc cacttcttta ttttaacaag acaagcgctg ataagaaaac cccgaaaaaa 2894461 tgaattctct ccgacaattt atttgttttt gagacgcatg acgcgcatgg cgttcgccac 2894521 agcaagcagt gtaacgccga catctgagaa aaccgcttcc cacatggtcg caattccaaa 2894581 tgcaccaaga atgagaaaga tcgctttcac acctaaagca aagccgatgt tttgccacac 2894641 gattcgccgt gtccgtttcg caatccgaat cgcttctgct atttttgacg gctgatctgt 2894701 catcagcacg atgtctgcgg cttctaccgc ggcgtctgag ccaaggcctc ccatcgcaac 2894761 ccctatatct gcgcgtgcaa gcaccggcgt atcattgatg ccgtcaccga caaaaatgag 2894821 tttttcacta ggcaaaagct tagcttctaa tgcttcgacc tgcgcgactt tatcttgcgg 2894881 cagcagctct gcatatacct caccaatccc aagctgtttt ccgacggctt ctcccgtttg 2894941 tttcgaatca cccgtcagca tagctgtctg tttgatccca agcgacttca gatcagcaac 2895001 cgcctgtgct gcgtcttcct ttatctcatc cgctatgatg attgctccgg catagcgttg 2895061 atctacagca acgtgtacga ttgttccagc attttcatcc gggacatcct caatttgttc 2895121 tctttccatg agctttttat tcccagcaag gatctcagtt ccatttacct ttgcaaaaat 2895181 gccgtgaccg gagatttctt cgtatgactc aatctcatcg gaggaaagca ttttcccgta 2895241 agctttacgc acagattcag caatcggatg ctgtgaatga agctcagcgt atgccgccgc 2895301 ttcaagtaat ctatcctttg taaaaccttc cgcgggtttg atttctgtca cttcaaagct 2895361 gccttttgtt agtgttcccg ttttatcaaa caccgcgtat ttgacttgat tcaaagcttc 2895421 taaataattg cttcccttta caagcactcc ggcctttgag gccgctccga ttccaccgaa 2895481 gaaaccgagc ggaatagaga caacaagcgc acaaggacaa gaaatcacta aaaagataag 2895541 cgcgcggtac acccaatcgg aaagcgcggc gccagaaaga acaagcggcg gaacaaaggc 2895601 cagcaatacc gcaatgatca ccacagcagg tgtataatac ttggcaaact tcgtgataaa 2895661 gttttctgtc cgggctttac ggctgctcgc attctgaacc aagtctaata tttttgatac 2895721 tgctgattcc tgatagccct ttgtgacttc aatatgcaga acgccgtttt gattgataaa 2895781 gcctgacatt acatcttgtc cttccgcagc ttttctcgga acggactcac ctgttaaagc 2895841 agatgtatca accatcgctg acccttgcac gaccttaccg tccaggggta tgctttctcc 2895901 cggattaacc acaatgatgt ctcctgtctg aacgtcctcc gacgaaacct gttcgatgcc 2895961 gttctttgtt ttgagattgg cgtaatcagg ccgtatgtcc attaacgcac taattgattt 2896021 tctggaacgg ctgaccgcgg ctccttgaaa aagctcaccg atttgataaa acagcataac 2896081 ggcgaccccc tcagggtatt gctgaatcag aaaagcgccg attgtggcaa gagccattaa 2896141 gaaatgctca tcaaacacct gaccgcggat gatgtttttg actgcgcgga ttataatgtc 2896201 accgccgata atcaaataag caccgaggaa aaggaaaaat tcaatggttc ccgactgaac 2896261 caaatatgcc gctgcgccga gaatgacagc cgccgccatt ctgatcagca tattgaccat 2896321 tcgattacga tagccatcat cagctgattt ctttatatgc ttttggcgaa ccgttacatg 2896381 cggatcaatt gatttcactt ttttctctac tttattcgtg acccattgct cttctttccc 2896441 atcggctgag acagttaagg tgcttgccgc aaaatttacc gcgcatccgt taatgccttt 2896501 tatgcctttg actccatttt cgatttttcg ggcacaattg ctgcaatcca aaccgtccag 2896561 aacatattcc tgtttcacta gtctcacctt accttccgat ttagggttcc ctcttcaaag 2896621 cgtatcaatg agtattgtat ttattttata tatatgagca tatactcata tataagttac 2896681 acctattata tgttgttttc caagaaagtg tcaatgaaaa acaaaaaccg gcatatagcc 2896741 ggtttttcat tttacttttt gcagacgaag agcattcaga acaacggaaa cggagctgaa 2896801 tgccattgct gctcctgcta tccacggtgc taaaaatcca agtgctgcga ttgggatgcc 2896861 gaggctgtta tagccaagcg cccagaataa gttttgttta atgtttttca ttgtcaatct 2896921 gctcatgcgg attgcgtcgg caatgctgtt cagatcgccg cgaataagtg taatgtctgc 2896981 tgtttccatg gcaatgtccg tgccagttcc aatcgccatg ccgatgtcag ctgtggcaag 2897041 cgccggcgca tcgttaattc cgtcgcctac cattgctgtc tggcggcctt ctttttgcaa 2897101 gcgggcgatt tccgccgcct tttgttcagg aagaacttcc gcaatgatat tcgcaattcc 2897161 cgcttccttc gcgatggctt ctgcggttct gcgattgtct cctgtcatca tgatgacatc 2897221 aagacccaac tctttcagac gggcaacagc cttccgcgac gtatccttaa tcgtatctgc 2897281 aactgctact agccccgctg cttctccatc aatggataca agcataactg ttttcccttc 2897341 ggcctctagc tcttccattt gggcgagaag agccccatgc tcaacctgtt cgctctccat 2897401 taattttctt gtgccgacga gaatgctttt tcctccggct tcagccaaaa tgcctgcgcc 2897461 gacttttgct tcaaagcggg taagtttcgg tatctcaagc cctttatctt tcacgccagc 2897521 aataatcgct tcgccaagcg gatgctctga tcccgtttcc gctgccgctg caaattgaag 2897581 caaatctttt tcttcaaaac ggccgaatgg aatggcatcc gtcagacgcg gcttcccgtt 2897641 tgtcacggtt ccggttttat caagaacaat tgtatcgaga cgatgtgttt tttctaaatg 2897701 ctcgccgcct ttaaataaaa tcccgaattc agcagcgcgt ccagatccag ccattatgct 2897761 cgtcggagtg gcaagaccga gggcgcaagg acaggcaatg acaagaaccg caatgaactt 2897821 gctgatcgct tcggcaaaat cgccaggagc cgcccaaaga taccaaatga gaaaagtgag 2897881 aaccgcaatc cccaatacaa tgggtacaaa aatgcctgaa atctggtcag cgagacgctg 2897941 gatcggcgct tttgaccctt gtgcttcctc aacaattttg atgatatgag aaagcgcagt 2898001 atcctttccg acgttgacag ctttaatttt cagaaagccg tttgcgttaa cggttgaacc 2898061 tgtcacgctg tcaccaggat ttttgtcaac aggaagactt tctcctgtaa tcatcgattc 2898121 gtcaaccgct gaacggcctt caaccacttc tccgtcgaca ggaattcgtt cgccaggttt 2898181 gacgtaaaca atgtcattaa caagcacttc gtcgatcggg atgatttgct cctgtccgtc 2898241 tcttacaaca gtagctgttt tcgcttgaag cttcatcagc tttttaatcg catccgagga 2898301 acggcctttt gcttttgttt caaacaactt gcctaataaa atcagcgtca gcaaaatcgc 2898361 gcttgtttca taataaaggc cgtctgtatg cccgtgagag ccaatgcttt gaaaagttag 2898421 ataaagacta taagcgtaag cagccgtcgt accgagggcg accaatacat ccatattggc 2898481 gcttttattt ctaagcgcct tatacgcacc cacataaaac ggccagccga tcagaaactg 2898541 gactggtgtc gccagcgcaa actgcatcca cggattgaga aatatatccg gtacccaaat 2898601 gaatgatgta aatgtaaaat ggctcaccat cgcccaaagc aatggaaatg acaggacagc 2898661 tgaaaaaatc agtctcgccg tttgcttccg ttcttctttc tttttagcag cagcctcact 2898721 gtcctgttca cccttcaact ttagcttata tccaagctta tctaccgctt ctttcaaatc 2898781 gctgacagac gcttcttttg gattgtattc gaccgtaact gtttctaaag cgaagtttac 2898841 tggtgcattt gcgacgcctt ctattttgtt aagccgtttt tcaatccgat tggcgcaagc 2898901 cgcacaggtc atgccctcaa tatcgaattc agctttttct gtaacgacgt gatagcccag 2898961 cttctctatt ttttcctgaa tcgctgcagt ccctgtttca gcaggatcgt agattacatt 2899021 tgatgtttcc gttgccagat taacatttgc atccgtgaca ccgggcatcc gcttcaggcc 2899081 tttttcaatt ctggcagcac atgccgcaca ggtcatacca gagacctgca tcgcgatttc 2899141 cttttgttca ctcaacatac tcactccttt atatacacct ggggggtata taaaaatgaa 2899201 agaaatatcg cgcctcccta aaggcgcgat accttgaatc acttggctac gtcatagccc 2899261 tgatcttcta tcgcatccgc aatatctttg actgatactt tgtcagcatc aaacgaaaca 2899321 tcgactttac ccgcttccag attgacatga acggcactga cgccgtccag ttctcctacg 2899381 cttgtttcta ctgctttgac gcagtgctga caagacattc cttcaacttg caatgttttt 2899441 tgttccatat caattcctcc tgtttattct ttctattttc atcctaccat acccccgtag 2899501 ggtattacaa taaaaaacgc tttatgattt tgtgaacttt ttaaatacgt ccaaaagctc 2899561 agaaatggcc tgttccccgt ctccgctttt gatggcatct gctacacaat gatgggcatg 2899621 atcctcaagc aaatgaagcg ccacattttt cattgccgcc tgaacagctg aaatttgcac 2899681 aagaatatct acacaatatc tgtcgttttc caccatgttt tgaatgcctc tgacctggcc 2899741 ctcaatccgc ttaagccggt ttgtaatctg atccttttct ttcgagcttt tatggtttaa 2899801 tgttttatgt tcgttatgct tttccatgcg tacacctctg tttaatgata ttaattccca 2899861 ttatactgat tgtccaaacg gttgtctaag catgccgacg caaaaaatga atcagttagg 2899921 ttttaccatt tgatcaggag ggtatatact tctgttgata acgcttttaa aggggagaag 2899981 aaaagtggat acgatcaagg ttggaatatt aggatacgga ttgtccggtt ctgtttttca 2900041 cgggccgctg ctggatgttc tggatgaata tcaaatcagc aaaatcatga catcacggac 2900101 agaagaagtg aaacgggatt ttccagatgc tgaggttgta catgagcttg aagaaatcac 2900161 aaatgaccct gccattgagc ttgtcattgt caccaccccg agcggccttc attacgagca 2900221 tactatggca tgcatacagg ccggaaaaca tgttgtgatg gaaaaaccaa tgacagcaac 2900281 ggccgaagag ggggaaacat taaaaagggc tgccgatgaa aaaggcgtat tattaagcgt 2900341 atatcataac cgacgctggg ataacgattt tttaacgatt aaaaagctga tctctgaggg 2900401 atcccttgaa gatatcaata catatcaagt ttcctataac cgctacagac ctgaagttca 2900461 agcgcggtgg cgggaaaaag aaggcactgc cactggtacg ctgtatgatc tcggctccca 2900521 catcatagac caaaccctgc atttgtttgg gatgcctaaa gccgtgactg caaacgtgat 2900581 ggcccagcgg gaaaatgccg aaacggttga ctattttcat ttaaccctgg attatggcaa 2900641 gcttcaagcc attctatacg gaggatcaat cgttccggca aacggacctc gttatcaaat 2900701 ccatggaaaa gattctagct ttatcaaata tggaattgac ggacaggaag acgcactcag 2900761 agcgggaaga aaaccagagg atgacagctg gggtgcggat gttccggagt tttacggaaa 2900821 gcttacaacc attcgtggct ccgacaaaaa aacagaaacg attccatcag taaatggctc 2900881 ctaccttact tattaccgta aaatagcgga aagcatacga gaaggtgctg cgctgccagt 2900941 cactgctgag gaaggtatta atgtcatccg catcattgaa gccgcgatgg aaagcagtaa 2901001 agagaaacga accattatgc tggagcacta aaacaaaagc ctccccaaat aaggggaggc 2901061 tttttcatta gaatgttttt cctgcttctt tcgcacgcgc aatcgcgtct tctttgattt 2901121 gctgtgcttt atcaggctcc gcattatgtc cctctacgaa aatgccatcg aatgatggta 2901181 cgccgaagaa gttcatcatg atgccgatgt agcggtgccc catttccatc tcagccgcag 2901241 ggccttctga atagtagccg ccgcgcgctt ggatatgaat tgctttttta tcagttaaca 2901301 agccgacagg accttgttct gtgtatttga atgattttcc tgcaacagca acagaatcga 2901361 gatacgcttt catcactggc gggaatgaga agttccataa aggagtaaca aatacgtact 2901421 tatcagctga tgcaaattga tcgctaagct ctcccaaacg gcctactttc gctttttcgc 2901481 tttcagaaag ctcttcaaag cctgtacctg actgaagctt tccccatccg ctaaatacat 2901541 ctgcgtcaat gtgcggaatg ttttctttgt acaaatcgat atgtacaact tcatcatttg 2901601 gattcgcttc tttgtaagat tcgataaatg ctttacctgt tgccatactg tacgaagttg 2901661 cttcgtcatg tggatgagca gtgatatata atacttttgc catttttacc agccctttcg 2901721 tttttaaaaa tcacacatca attattatca tacagatgca taatgattat tctgtctctc 2901781 ttagacttta ttatagagac aaagaaattt actttcaagt aaaacatctc gaattaaaga 2901841 ttatttaact ttcccaaaca gcttactttt caaaagctgt tctcaagccg gaatacagcg 2901901 cggacaattc tttactgatc cgaggataat gagggacatg cggcacttga atatccgcag 2901961 gcatcctttt catgataaag gattgctcag cctgttcaaa aaacgcccgc agctggttga 2902021 tctcttcatc agaaaacgga gcagacggac ggcggtgagc ttgcgccgag agcaaatagt 2902081 accctaagtg ctgagcaccg gaaatggcag gccagagcgc atccgcattc gcgtgaggaa 2902141 actcgccaag cgccttgtca tacgcatccc gaagcctgac aagactcacc cttaacttgt 2902201 gttcgtcggc aatttgcccg gttaacagtt tctccataaa ctgcccttcc agccggatga 2902261 cattccgcac aagttctggc agccgcttgg ttgaaaaccg ccgccacaaa agcattgttc 2902321 ccaacagccc gatcacgctg ccgacagcta catcagtcag cctcgctatc ataaaataac 2902381 cggcgcccgc cccgccatgc atactttctg tgataacaag cgcatttgcg gttaaaaagg 2902441 gaacagccag cgcataattg cggacgatca gcatctcaag aagacattgc agcgctgcaa 2902501 tacaaaacgc aatataaaca ccgcccggct taaaaaacag gattgcgcct gccagtataa 2902561 caccgatcac cgttccggcc gaacgctgaa tagccctgtg aagcgtaaaa acaacagtag 2902621 tgccaagcat gaccgctgct gccgaaagcg gaatccaata ggagcgtgca aagccgaatg 2902681 cgagggcaaa catatcggcg gcaaacagaa caattccgta ctttaacgct ctaatcaaaa 2902741 ctggagactt ccagtcaaag gcatttctca aaaagtaaaa agaggatggc aggcggcttg 2902801 gttccccgtc aagctgctta tcaaaacgtc ctgaagcgat atacaaaacc tcattgattt 2902861 cttcaaacag cttccgccta ggctcagatt cattttcatt aatctgaaac gtattgaaaa 2902921 cccgtgcatt cgcaagcata tctccggttt ggcgaagtgc cttttcaatc tgcgcggtct 2902981 ctctgtccgg cgtttcagct gaaaaatgaa taatggcaat aaatatgtcg tcagctttct 2903041 caaggaggcg aaaaaatcgt tcatcatgcc gcgatttttt ccgtctgttc cctttcccaa 2903101 gaaccgtttg gcgggctgtt ctaagcatga gcaccgtctg atgctgtgcg ttatgaaaac 2903161 ctggcgttcc gacggctgaa agacatgcag ccagctgatg atatgttttt tgcagcaccg 2903221 ctccctccgg tccatgtttg ttccataacc agccgattaa agcgataccc atggcgaaaa 2903281 tgccgccgag aaacgtcagt cccgctctga acagcgcttg tgaaggatcg gccggcagcc 2903341 cggaactgac taaaaaggca aggacaaaaa acatcggcgc agggccttga atgccgagcg 2903401 cgctaaaaat aaacatcgcc gctgcaccga tcagccccaa aacagccgcc atcatccaaa 2903461 gcatcccgga caaaagcgtc cctaaaccaa atgagagggc gatcccaata gaaaccaaga 2903521 gcagcttcaa ggcgcgcttt ttgtacgatt caccgcccgc atataaataa acaaagcctc 2903581 cgatacttgc aattaatccg taatccgtgt gacctgccaa tgcaccgacc agcacaggaa 2903641 accctgaagc gaaacctgat ccgatagcct ttttccaagg aaatggattt gcatgaatgc 2903701 gaaaggcatc cttcacgata ggcatgattc tttgattgtt cgcagcagtt ttgttcattt 2903761 gacaaaatcc ttttcaatga atgtgtagaa cttttccagt ttcttcgctt tagtatgccc 2903821 aaaaacgcgg ttagcttctc aattggtgcg cacgataaaa aaacagagac ttataccgtc 2903881 tctgcttcat tacatcagtt tattataaaa gcggcacctg tcaggactgt tttgtccttc 2903941 tgccttcctt caagagcagg tgaataaaaa ataaaggata aatcaataga tacccattaa 2904001 acagccacca cacaagatca aagtcactgc tgaatgtcca gaatgatagc gcctgcagac 2904061 ctgaacaaca ggtcagcaca agagaaatca gcgccatcag cttccagtca gcacgattca 2904121 cccgctgtag gtacaagctg tacaaccctg tgacagaaat caggatatcc agcggaaaaa 2904181 aagaccagtt ccaagcgatc ataaacggat ggtcatgatg tttaaaagcc cagctttccg 2904241 gtatgagcga aaatccggct gacagccagt acaagataaa accgatatca gtcacgagaa 2904301 aaaacagctt catatatctc atttgtactg cccgctttta tgtaccggct cagacaccgc 2904361 aacatgctcg atcaggttta aagacacaac accggcaata atcaatccaa ttgaaatgac 2904421 tttcatgaca ctcacatgtt cttgaaaaaa caaaaaacca acgactgtaa tcaagacaat 2904481 tcccatccct gaccatacag cataagcaac tgatacatca atggatttaa gcgtaagcgt 2904541 cagaaagaaa agactccctc cataaaagaa aatcaacagc aaactgggaa taagctttgt 2904601 aaaaccagac gatagcttca tgctgacagt tcccgcaacc tcaaacaaaa tcgccaagca 2904661 tagaaacacc caattcatgt ggcatcagcc tcctcatcag ctgttatacc gttaaacaaa 2904721 acatctacaa ttgattcaag tacctctcct gtcgtgaact gatgtttcag cggatattca 2904781 gggtcataca cttgattgat gctccctata tacatgtgaa caaacaggtc cggattgatg 2904841 tttctgattc tcttttgctg tttgcactca tttaataatg ctaggacaat cgcccattct 2904901 tccttaataa acgcgtctaa tgtaagccac gcatcgtaat ggtatttctt tagttcattt 2904961 aataatccca tgttcagcag ttccatcccc tgcggaaggc tgatcagcat ttgtttcacc 2905021 ttttcgagca catttaaact ttcattttca tagatgtctc tttctatttg cttcatttca 2905081 gctataaatt gttcgacaac cgcctcaaca agctgatctt tagatgaata atatgcatag 2905141 agcgtccgct tgctcgttcc cagcgctgcc gccaaatcat tcatcgtaaa tgaaaatcct 2905201 ttctgcttga tcagccggaa ggtttccgcc agaattcttt tatccatatt aatcccccgc 2905261 tttcggtacc aagaaaacta tttcggtacc aatattatac ggcagaaatt tatggaaatc 2905321 aacaatatat aaaaaaacct ctcctattgg gagaggttta aaagacactg cggaccaaac 2905381 cgccgtccgc ccgaagtgcc gcgccattga tcgcagagga aagcggactg cttaaaaatg 2905441 taacgaagtg ggcgatttct tccggacgga tcagtctttg aataatagat gtcggccggt 2905501 tttctttcat aaaacgtgcc tcagcttctt gaacagtcag gttttcacca ggatacagcg 2905561 agttcagcat ggtttccaca ccctctgtta aggtagagcc cggcatgacg gtgttgactg 2905621 tgacattcgt gccggttgcc agctccgcca aactgcggga aatggacagc tgcatcgttt 2905681 ttgtcgcact gtaatgggcc atttcctgtg acggcataat cgccgcttca ctggcaatga 2905741 aaatcacacg cccttctttt ttctctatca tgttatgcaa atacctgcgt gtcagcctta 2905801 caccgctcat aatattcact tcaaaaaaac gaaaccattc atcgtcggga atatcaaagt 2905861 actccgccgg ttcaaaaatc cctaaattgt tgaccaaaat atcaacctct ggatatgcct 2905921 gaaacagctc attgcagcct tcttctgttc ccaaatcaaa tgcagccgga taaagaaccg 2905981 cttcagcatg ttgtgttttc agttcatcta tcgtttgatt cactttctct tcccggcgtc 2906041 cgttaatgat cactgccgca ccttcttcag ctaacgaaga ggcaatagct tttccgatcc 2906101 ctgatgtcga accggtcacc agtgcggttt ttccttgtaa attcagcttc attattcatc 2906161 cctccgtttt tgattcctct tatttattga cagaaatctg attggtgaaa catctgctct 2906221 gcaatcagta tgaaacagct gggattgaaa tggaagtacg cactttttgg tgcctgtggt 2906281 ttggagaaaa aataaagcag aacctcttaa gaggttctgc tttattgtca gtatgtatgg 2906341 agacggtggg agtcgaaccc acgtccagaa acatcgatta cttaagcgtc tacgagcgta 2906401 gcctgcatat ttatggtttc actcatcttc ttgcctgcgg gcgggccttc cgagagctag 2906461 tctgttcatc tcttcttacg ttctcagacg ggaacgcaag cgtagcctac ttggatgtgc 2906521 tcttcacaga cacataggca atgtcaggaa gagctcgctg cgcttattag gcagctaatg 2906581 ctacgttttg gttaaaactg ttagttttgc cagttatatt taagtgcgtg tttacgagat 2906641 cgcctctcgg ctcgcagctc aagctcgatc catccctgtc gaatccgtaa cgtccccttg 2906701 gtataaggga aatacgggag aaaatatcaa gctctcactc aaactggcta tagtcttatt 2906761 ataacatgat cacggctctt ttcaattgtc aaatccttca aatgaatggc gtcgtgatct 2906821 gatcgtgaac acagtatagc acaggcctga ttttcgaatc aagcactatg cctttagaag 2906881 cctttttgac tgtctctgaa cgctctttcg atttcccgct tcgcgtcctt gcgcttcaga 2906941 tcttcccgtt tgtcatagtt cttcttccct tttccaaggc cgagaagcac tttggcaaag 2907001 ccgtttttta aatacagctt cagcggaacg agagaatagc ctttttcctt tgttaacccg 2907061 atcagcttat taatctcctt gcggtgcatt aacagctttc ttgtccggag cggatcgtgg 2907121 ttatagcggt ttccctgctc atatgggctg acgtgcatat tgtggagaaa cacttctccc 2907181 cgttcgattt tggcgaagga atccttaagg tttacgcggc cggcgcgaat cgatttgatt 2907241 tcggttcctt gcagaacgat gcctgtttca taggtttctt ctataaaata atcgtggttg 2907301 gctttcttat tttgagataa tacttttcct gacccttttg gcatgccaga acctcctctc 2907361 tctaaggaaa aactgtccac cttttgcgat acgctctatt ttaccaaatg tcacgtaccg 2907421 ctacaatgaa aagctgtttc cgaaagaaag caaatagagc gctgcggccc tatttgctgg 2907481 ttgagctgct atttcttctt tttccgtttc tgtttcggag cattctggaa gccgcgtttt 2907541 ttctttttct tcttcggctt agtgaaccac tccccttttt cctcagacgg agctggagaa 2907601 acaggtgtat tggtgctttg aacacgtttt ctggcaggct ttccgcgttt tctgctccgg 2907661 ctgctgtcca attctctcgg acgccgcgga gtgcctttca tgccgacaat ttcaaagtcg 2907721 atattgcgct catctttatt gacatcgaca accttgactg tgatttcatc cccgatgcgg 2907781 aagacgttgc ctgtccgctc gccaatcatt gcgaaatgct gttcgtcaaa gcggtagtag 2907841 tcatctgtca taaagctgac atggacgagt ccttcaattg tattcggcag ctcgacgaac 2907901 attccgaagt ttgtcacaga gctgatcatg ccgtcaaact cttcaccgat tttatcaagc 2907961 atgtattccg cttttttcag atcatccgtc tcacgctcgg cgtcaactgc acggcgctcc 2908021 atagatgatg tatgttcggc gatatccggc aggcgttcag cccacttttc ctgtgtcgct 2908081 tcatcgacct tgccgttgat caaatacgtt cggatcagac ggtgaacgat taagtccggg 2908141 taacggcgga tcggtgatgt gaaatgcgta tagaattccg ttgacagacc gaagtgcccc 2908201 aagctttgcg ggtcgtattt cgcctgtttc atcgaacgga gcataacagt agatataacc 2908261 gtttcctctg gtctgtcacg cacagcgtcc agaatgcttt gcagcgcgcg cggatgaata 2908321 ttccccgccg ttcctttcac cacatagcca aatgtcgtca caaattctaa aaacttttgc 2908381 agcttttcag cattcggctc ttcgtgaatc cggtatataa acgggacatt catccaatgg 2908441 aaatgctccg caactgtttc gtttgctaca agcataaatt cttcaatcag cttctcggcg 2908501 acagagcgtt ctctgatcac aacgtcttta accgctcctt cgtcatcaac aagcaccttt 2908561 gcttctttga aatcaaagtc aacggcgccg cggtccatcc gcttatcgcg cagaatttga 2908621 gccagacgct ccatgtcttt gaacatcgga acaagaggct cgtatttttg tttcagctct 2908681 tcatcatcat caacaagaat tttattcaca tctgaatatg tcattctttc cgttgttttg 2908741 atgacacttt ggaagatctc gtgctctgtc acctgtccct gactgttaat tgtcatttca 2908801 caagaaagcg tcaggcggtc aacctttgga tttaaggagc agatgccgtt tgacaatctg 2908861 tgcggaatca tcgggatgac acggtcaacc agatacacac ttgtccctct ttcaagcgct 2908921 tctttgtcaa tcggcgagtt ttcggttacg taatggctga catcagctat gtgaacgcca 2908981 agcttgtagc ttccatcatc aagcttcgtc acggtaactg catcatccaa atccttcgca 2909041 tccgcaccat caatggtgac aatcacctgg tcacggagat cacggcggtc tttcagatct 2909101 ttttcatcaa tcgtgtcagg cgtacttgat gcctgttcca tcgcgtcagc tggaaattct 2909161 cccggcaggc cgtgcttatg aatgaccgat aaaatatcaa tgcccgggtc gtttttgtgg 2909221 ccgagaatgg tttcaacctc accctctgcg ttcatgcggc cttcaggata gctcgtcagc 2909281 ttgacaacaa ccttatgccc ttccgcagct ccatttttcc catttttcgg aatgaagatg 2909341 tcactcgtga tttttttgtc gtccggaatg acaaagccga agtttctcgt ttctgtatac 2909401 gtgccgacaa cccgctgaat cgctctttct aaaatccgta tgacggttcc ttcctgcctg 2909461 gagccgcttg attgtgagtt cagacgcacc atgacgatat cgccgttcat tgccgtattt 2909521 agctcattag gcggaataaa cacatcactt aacgacgtat cctcaggcag caaaaaggcg 2909581 aatcctttcg catgggctga aatctttcct tttattaaat tcatcttctc cggaatgccg 2909641 tagcggtcgc ttctcgtccg tacgataagc cctttttctt ccaaggcgac taacgctttg 2909701 acgagctctt taaactcctc ggcttccgta atatttaaca tctcctcaag ttcctgaacg 2909761 gtcagaggtt tgtacgcctc ttccttcata aacgagagaa gcttttccat aaatgcttct 2909821 ttttccatta tccgacctcc tgttgattac caatcgagct tctctaaaaa ttcatacaca 2909881 tcctgatgga cgaggtcacg ttctttgtcg agtgtaatga catgccctga ttcctcgtac 2909941 catttcagct gtttatcatc agtttccact tcgttgtaaa taatattggc gctttcggta 2910001 ttaatcatgt ggtcatgacg ggcctgcacc acaaatgtcg gtgaataaat catatcgaca 2910061 ttattccgca catcagcaat taagtcttgc agcgccttga gggtattcat cggcgttttt 2910121 tcgaattctt tcatttcctc ttcaatttgc tccgggcttt tcccctcaaa ctttttgtaa 2910181 ttgcgagcgt atgaaagaac gccttgatac atgacctctt cactcttaat atgcatcggt 2910241 gcgcacattg ggacaattcc ctttatgggt acagtgtaac ccaatttcag cgaaaaaacc 2910301 ccgccaagcg acagtccgca ggcagcaatg ctctcataac cttcagattt taaatattca 2910361 tagccatcca ttacgttttt ccaccagtct tcgggccccg tatgtacaag ttcttcaggc 2910421 gggacgccat gtccttcata ttgaggcgcg tggcacgtat agccgcgttc attcaaatat 2910481 cgtcccagca tccttacatc cgctgtattt cctgtaaagc catgcagcaa aagcaccgct 2910541 ttgtctccgc ctttaaatgt aaatggtttt ggtgtcacaa ctttcatgct catgtctccc 2910601 tttctatctg cacgatcatt ttagttttcc acagtttaat cagaaaaaaa cgttttgaat 2910661 atcatccaga aacgtgaaaa aggcctgact tcacatcaga ccttatacaa acattgccct 2910721 ataggatata agcaagcgca atcgttaaca cgaaaaacaa gactgccagc actaccgtaa 2910781 tgcggtgcaa aattaaatca agacctcttg ctttttgttt cccgaagagc tgctccgctc 2910841 cgcctgaaat cgcaccagat aatccggcac ttttactgga ttgaagcaaa acgacaataa 2910901 taagtgcaat gctgacgata accaataagg taatcaaaac tgcgtgcatc ccatacacct 2910961 ccagactcac tggctacatt acttctattt tacatgaaaa gggttggcat gtcacgctgt 2911021 atcagacgcc aaaaggccgg ataagacgtt ttatcttggt taccctattc atatgaaaag 2911081 gtcaaaggag aaaagcgatg ccgcttatca gcatagacag caggaaacat cttttttatg 2911141 aagaatatgg acagggaatc cctatcattt ttatccaccc gccgggcatg ggacgaaagg 2911201 ttttttatta tcagcgcctt ctatccaagc atttcagggt gatttttccg gatttaagtg 2911261 gccacggtga tagtgatcac atcgatcagc cagcgtctat ttcctattac gcaaacgaga 2911321 tcgcgcaatt catggacgct ttgcacattg ataaagctgt gttattcggg tattctgccg 2911381 gaggcttaat cgcgcagcat atcggcttca cccgcccgga caaagtgtca caccttattc 2911441 tgtccggcgc ctaccccgct gttcataacg taatcggcca gaagctgcac aaactgggaa 2911501 tgtatctgct tgaaaaaaac cccggtttgc tcatgaaaat cctcgctggc agccacacaa 2911561 aagacagaca gcttcgcagc atattaacag accatatgaa aaaagcagac caggcccatt 2911621 ggcatcagta ttatctggat tcgcttggct acaactgcat tgaacagctg ccccgcctag 2911681 aaatgccaat gctgtttatg tatggcggcc tgcgggactg gacctttaca aacgcaggct 2911741 attaccgaag atcgtgcaga catgccgaat ttttcagatt ggaatatcag ggacatcaat 2911801 tgccgacaaa acaatggaaa acgtgcaatg agctggtgac agggtttgtg ctgacacatc 2911861 attcatagga atagaaaacg cttggcttcc ttgcgttttt tgttacttta ttgacttttg 2911921 tcaacgaaat catagtaaaa aagatcctca aatttcaaat taaaatagtg aagcatttta 2911981 ccaatcacaa gctgccccgg ccttctttct ccattcagca cgcggctcag tgtggcgggt 2912041 gagactccga tttccagcgc aagctgatta agggaataat cgttattaac catatactgc 2912101 aagacataat cacgtctaat ctgtatcttt tctactggca ctttcctcac cttccattcc 2912161 tgaaaaactt ttttctatac ttttacatta cggcttatgt taacttttgt caatacattt 2912221 ccagtctacc tattcccttt agtcaataaa catactaaaa tatgagtaac agtgagggac 2912281 ggggtgagat atatggaaag ctttggcgaa caattacggg cattgcgtga agagagaaag 2912341 ttaacagtca accagctggc gacttattca ggcgtaagcg cggccggcat ctccagaatc 2912401 gaaaacggaa aacggggcgt tcccaaacct gccaccatca aaaaactggc agaggcctta 2912461 aaaattcctt atgaggggct tatgtacaag gctggttaca tcgaagaagt gcatgaagcc 2912521 agggcccctt atgaaacgaa gtgcaagctg cttgaaaaag cggaggccta tgacctgaaa 2912581 aaccttgcgc ttcttgagaa cgaaaagtgg caatatctca ataaagaaga tttgctcatg 2912641 ctggatcatt atttttcgtt tatttcagat gaagcgaaaa aacggtctgc tgatgactga 2912701 ctcttgatag aaatgtgagg cgatagacca tgtcaccgtt cggacagcaa ttacgggagc 2912761 tgcgccgcgc ccgcaaactg acagtgaatc agcttgcggt gtactcaggc atcagctcgg 2912821 ccaccatttc aaaaattgaa aacggcaaac gcgggacgcc aaaacccgcc acgattaaaa 2912881 aactggcagc cgtcctgaaa gtgccgtacg aaaacctaat ggccgccgca ggccatattc 2912941 aggcctttcc tgaagaaatc cgcgaagcat ctgaaggcta tcaatccgtt tatgaaattt 2913001 accagacggc tgtcacacgc ggagcggagc acctcccgat tttcaatagt caaaaatggg 2913061 aacatctctc aaagcaggat attgaaaatc tcagcaaata cttcgatttt ttgtcttcag 2913121 aagcaaaaaa acgcgcctct tcctcataat cccctgtttc tctttctata ttttatcaat 2913181 cacgcttgca tgccctccct cgttatttgc gttataatag tgacagacga ggtgaaaagt 2913241 atgaaccaat cagaaatgtg tcctagattt gaaaaagcag tcgacatctt aagtaaacgc 2913301 tgggtcgctt taatcgtatt tcagctcttg aacgggtcgc agcgatttag cgaaattgaa 2913361 gcagcacttc caaatctaag cggcagagtt ctgtcagaac ggctgaaaga acttgagctt 2913421 gaaggagtag tgaagcggga tgtcatccct gaaactccgg ttcgcatcga atattcattg 2913481 actgataaag gaaaggcact agcacccata ttaggtgaga tttctaaatg ggcgactgaa 2913541 tggattgacc cttcctttct tgactaattg ctaaaatggt tctgatctca aagacgagaa 2913601 aagaaccgtt ttttattttc caggtgaaaa aaagatatct cagccgatat atagtacatc 2913661 cacacattac gtttttaaag gagaccacta tatgcgactg acgatttccc gcaaattcag 2913721 cctggtattt ttgacactga tcctgatcaa tttacttgta ggcggaatag gcgttcttaa 2913781 tatgcagcat atcattcaaa aaacagatga aatcaacaca aaatggattg acggcatcaa 2913841 aggaatcact tcaattaatt atgtaaccga gcacctgtct tctaaagaaa aggactttct 2913901 gatttataca gacaaaagta aaatggatac acttgatcaa gaaatgaatc aaatcatgga 2913961 agacattaac caaaagctcg ataactacga aaaaacgatc tccactgata aagagcagaa 2914021 actgttcgag cagcttcaaa ctaaagtgaa tacctatatg gatattcatg cgcaaattat 2914081 cgaaagcggc cgcacgaatg acatggacaa agcaagaggt ttattggttc agactgaggc 2914141 cagctttgag gatatgaaaa aaacaatcac tcagcttgtt gacttaaatc aagaaggcag 2914201 caacacagcg gtaaaagaaa cgaaggccgt ctatcataaa gggctcattt acactgcttt 2914261 gcttgtggca gcatcaatcc tcatcagcat tttcatctgg ctttatatca cgcgaaacat 2914321 tgtaaagcct atcattcgca tgaaggaatc tgccaatcat attgccgaag gcgatttgtc 2914381 gaacgatatg gaggccctca actcaaaaga cgagctgggt gatctgaatg aagcgctgca 2914441 aaaaatggta gggaatctga gagatattgt cggatattct aaagacatat caagccgggt 2914501 tctttcttct tcacaggtgc ttgcaaccgc aacgaatgaa acaagatccg gcagcaaaca 2914561 tattaccgag acgatgaacg aaatggctga gggctctgaa cagcaggccc aagacgcggt 2914621 gacgattgcc gaatcgatga atgagtttac cgaaagcatt gataaagcct ataatcacgg 2914681 catcacaatc agcgatacgt ctcaaaacgt tctcgaactc gcggtaagcg ggaacgaaaa 2914741 tatggctacg tcattacagc aaatgaaaac catccatcat attgttgaag aagccgtgca 2914801 taaagtgaga tcactggaac agcattctca ggatattaac aagctcgttc aggtcatcaa 2914861 cgggattgcc gagcagacga atttgctgtc ccttaacgcc gcgattgaag ctgcccgcgc 2914921 tggagaaagc ggcaaaggct tcgccgttgt ggcagaggag gtcagaaagc tggctgacgg 2914981 cgtttctgat tccgtgcagg acattacccg gattgtaaac gggacacagc aggagatcca 2915041 cactgtcatt acgtacttgg aaagcagctt tacagaagtc gaaaaaggaa cggaaaacct 2915101 gacagacacc ggacaggcta tgcagcatat caaacaatcc gtcacccatg ttgcagacag 2915161 cattaaggaa gtaacggatg gcttgaagca gttaacaaac caatcgatta ccatcaatca 2915221 atcgattgaa aatatcgctt ctgtatccga agagtctgcc gccggcattg aagaaacatt 2915281 ttcaattacc gagcaatccg cccattcgat ggatcaagtg cttctaaatg ctgaagagct 2915341 tgagcagctg gccaatgagc ttaatgagaa gatgggtcag tttacgattt aaagagaaaa 2915401 aagaggctgg actccagcct ctttttctat tctatgcagc tgattgaaca tgtttcgccc 2915461 cggttctttt tttcttcacc ggacttaatg cccgctccag ccaagccatg agcaaatccg 2915521 cccctaccgc catcaccgca gttggtatcg ctccggctag aataatcgca gttccgtttg 2915581 ttgcgtttga gccgcgtacg atcatgtccc caaggcctcc ggcaccgaca aatgtgccga 2915641 tcgctgtaat tccgatggca atgacgagag ccgtgcgaag gcccgccata atgacagaaa 2915701 gtgcgagcgg gagctcaacc attctgagca cttggaattt cgtcatgccc attgcttttc 2915761 cagattctaa gtaggcatgt tcaatactga taatgcctgt gtacgtgttt cgaataatcg 2915821 gcagcaggga atacagaaat aatgatagaa tcacggtatt tgcgccgagc cccataacaa 2915881 gcattaagac ggccagcata gcgagcgccg ggattgtttg aataacgttt gttacggcaa 2915941 acacccaggc tgacaaacgg cgaaaatgcg cgatgaggat tccggccgga accccgacga 2916001 cagcggcaaa taaaacgccg taagccgaca tgagaaagtg gcggccgaat tcatccatga 2916061 cgtaactgcc attctgcgcg taatacgtca ttaactgttc aagcacgttc attgacctct 2916121 tccccctttc acgattcgaa atagcgatgt ttttctaaat attccttggc aacgacagac 2916181 ggttctttga gattgccgtc gacttcatag ttaagctcct gcatcgtggc tgtgtcgatt 2916241 tttccgagca ttttcttgat gatgccttca agttcaggat gttctttgag caccttttcc 2916301 ggaacaaccg gagagcagtc gtacggcggg aaaaattgtt tatcatcctt tagcattttg 2916361 agaccatagg acttgattct tccatcggtt gaatacgcaa gcacaatgtc catttttccg 2916421 cttttcaccg cgtcgtacac aaggccgatc tgcatcggat acgtgccgcc gaatgtcatg 2916481 ccgtaggttt tcgtaaaatc ctgatagccg tttcctttga gcttcatcca atagttatca 2916541 acgcccagct ttaattgcgg cgcccatttt ttaacgtctg atacggtctc taaatggtat 2916601 tggtcggcca gctccttgct gactgtaaag gcatatgtat tatcaaaccc gtaggagtca 2916661 taccacttta aatcatatct ttttttaaac tcccgctgag taagcgccag cgctttgtcc 2916721 ggatcttttt caggttccat tctcaacgtg cctgtcagcg cgtctcccgt atatcttgtg 2916781 gccgcaatgt cgatttcccc gttcattaaa gcctgctgct gcaccgcgtt ggagccaaga 2916841 tttttaatcg ttgttgtttt gagatcagta tggtgttcga tcaactggcc aagcatgctg 2916901 gcgatgattt ctgattcgct catgctttgc gcgccgattt taatggtctg gtctgcagca 2916961 gcgctgagac caggaagcga acagccgctc agcgtcagcg ttgccgcaag tgctaaacct 2917021 atcattaatt tgagatattt tcttttcatg agccgcctcc ttatgacaat tccttcaatc 2917081 tctgcatgcc ggcaggtgtc agttttcgtt cagcaactgc cagcacataa tcaatcacaa 2917141 ttgccaatat cgtgacaggt accgcgcccc cgatgatata ttccggctga tataaattca 2917201 gtccgataaa aatgtaatca cccaatccgc cgcctccgat aaaggaagca agcgtggccc 2917261 agccgattaa gtaaatcgtc gatgttctga ttcccgccat gatcactggt gcggcaagcg 2917321 gcagctccac caagcggact tgttcagccg gcgtcattcc tattccttta ccagactcga 2917381 gcagattttt gttgacgccg cgaatgccgg tatacgtgtt gcgaagaatc ggcaatacgg 2917441 aatagaaaaa caaagccaca atggccggaa ccttccctac accaaggagc gggataaaaa 2917501 aagcgaggat ggccagactc ggcagcgtct gaatgatatt gacaatgccg ataatggtgc 2917561 cggctccttt tttcattctg gtaagcacaa ccccgagggg gacggcaacc agcacaccta 2917621 agatcacagc aatgagcgat atcgtaatat gctcgtatgt tttataaaga agctctcccc 2917681 cattggtttg caaaaattga acaatatgat gcatgactta tcgcccctcc ctatgacaat 2917741 gctgcgagct gcttttcttc tccccagagg gagtcataca cgatgtcgac cagacttgcc 2917801 ctcgtcacaa ttccgatcag gcgtcggtct tcatccacaa cgggaacata tttgacaccc 2917861 cgttttaaaa ttttgcggac cgtgtcgcgc agcagtgtgc cgcccagtac tgtgtatata 2917921 tcttcatgta aaacttcact gacgagattg gcctttttcc ggcattgatc aatgatttca 2917981 acatcgacat agccttgcag aacgcgctcg tcattgacga ccagcaatga atcgacccgt 2918041 tcctgcctca tcagctgaat ggcctcagaa agcgttttat ccgcggtgat cgttacaggc 2918101 tgtgtgttca taatctggtc aacccgttca acatccgggc tggatgactg aatcagccgc 2918161 tccttgccga taaattcctc aacaaattcg tctgccggat ttcttaaaat gtcatcgggc 2918221 gttccaactt gaacgatttc tcccgctttt aaaatcacaa tccggtctgc cagcttaatc 2918281 gcttcatcca tatcgtgggt aacaaatacg atggttttat gtaaggtttt ttgcagtttt 2918341 ttaaattctt cctggaggga atccctcgta atcgggtcga gtgccccaaa cggttcatcc 2918401 attaagataa gcggcggctc cgcggcaagt gcccgtaata caccaattcg ctgctgctgc 2918461 cccccgctta attcatgagg gtaacggtct acatattctg gccccatatc gaccaatttt 2918521 aaaagctcac gcgcccgctc tttccgctgc tgctccggcc atttcagcag ttttgggacg 2918581 agtgagatat tctgctgaat ggtcatatgg ggaaacaggc cgatctgctg aatcacatag 2918641 ccaattttgc gcctgagctc tacaggatcc tggtccatga tgttttcgcc gtcaatgaaa 2918701 atcttcccgg cggaaggctc aattaatcgg ttaatcattt tcattgttgt cgtttttccg 2918761 cagccgctcg gcccgataaa gcagataaat tcgccttttg caatcttaag atttacgttg 2918821 ttcacggctt ttttgccgcc cttgtatgtt ttcgagacat tttctaatgt cagcaaacat 2918881 cgcacctcca aaattaagtt tattcaattt gttcagttta aatttaattt ttcagacaat 2918941 tgaatgcttc ccattataga ataaagttta taaaataaaa agtttacaat ttgttcatat 2919001 tatttataaa gtatgtgtaa acgctgattt acccgcattg acgtgtgttg atctccttat 2919061 tgctccaatt tcctgccaaa ttctcttttg acagcatttt cgccgtatca aaaatgtggt 2919121 atattgacat cggaattgtt agctgaaagg atgaaaccgt tggagaaaga tccgttaacg 2919181 atcattgaac aagccgagga ccattttata gaaagaatcg cggaaaacat gcatgcattt 2919241 ggaatgccct ctaccgtcgg acgagtgctg ggcattattt atatgaatcg aaaaccgatg 2919301 acgcttacgg aattatctga ggccaccggc atgagtaaaa cacgtatgag ccaggtagtg 2919361 cgggaaatgc ttgatgccaa cattgccgag aaggtattcg aaaaaggcgt gcgaaaagat 2919421 ttatatgagg ttgagcagga ctactatcaa acatttatca cgctgttttc agccacctgg 2919481 agcaaagtcg tcagcaaaaa caaaatgatg cataaaaaac tcaatcggga gctgcttagc 2919541 gtgttggatg aagagcttac tcctgaagcg gaagaaaaag tgaatgagct gctgaaggaa 2919601 ttaaaggaat ggctcgatta ttataattgg ctcagccgtt tgattgagtt ttttgagagc 2919661 gaagacattt ttaaatatgt gccgaagccg taaaaagttc ccaaattcaa ttctgggaac 2919721 ttttttaagt ccaatccaaa tggttgaata tcaaacttcg agctcccaac gctggaaaat 2919781 atgtttaaca gatactaaca catgttgttt atttaaaaaa accacctctg ttgtatttaa 2919841 atagaggtgg tttttctatc agctataata aaatttcctt ttttcttttt aatcgggctt 2919901 aatgctcgtt caagccagcc catgaccaaa tcggcaatca ccgccatcag agctgtgggg 2919961 atcgctcccg ctaatataat cgcggttccg tttgtggcgt ttgatcctct gacgatgatg 2920021 tccccgagac cgccagcacc gacaaatgtc ccgatggccg taatgccgat cgcaatgaca 2920081 agcgcggtgc gcaggccggc cattatgaca gaaagcgcaa gcggaagctc gaccatccgc 2920141 agcacttgaa attttgtcat ccccattgct tttcccgatt caagataggc gtgctcaata 2920201 ctgataatcc ctgtatacgt atttctgata atcggcagaa gagaatacag aaataatgac 2920261 aatatcaccg tattagcgcc cagccccatg acaagcatca gcacggcgag catggcgaga 2920321 gccgggatgg tctgaatgac attcgtgacc gcaaaaaccc atccgcttaa tcttctgtat 2920381 ctggctatca ggatgccgag cggaattcca acaatggcgg caaataaaac gccatacacc 2920441 gacatcagaa aatggcggta aaattcctgc agcacgtaac cgccgttttg cgaatagtat 2920501 gtgccaagct gctgtagtac ttccatatga tccacctctt ttcttagtca aaataatgat 2920561 gtttctctaa aaattccttt gctacgacag acggctcctt cagcttgcca tccacctcat 2920621 aattaagttc ctgcatcgtt tccgtgtcga tttgcccaat cagcttattg atcacacctt 2920681 caagttccgg atgctcctta agcacctttt ccggaatcac cggtgaacag tcatacggcg 2920741 gaaagaaacg cttatcgtct tttaagattt tcagatcata tgctttaatc cgtccatccg 2920801 ttgaataagc caaaaccgca tccattttcc cgtttttgac tgcgtcatag actagcccga 2920861 tctgcattgg ataagttgtg ccgaactcaa agccatatgt gctgacaaag cctttatacc 2920921 cgtcgccttt tcgtttcagc caagcattgt cgacgcctaa tttatattgg gaagcatttt 2920981 tcttcaggtc agacacggtg ttaatatgct ccttttccgc aaactttttt gttacggtga 2921041 aggcatatgt gttatcaaag ccgtaggaat caaaccattt ataagaaaag cgcttttgaa 2921101 actcgttctg cacaatgttc agcgcttttt tcggatcttt ctccgcttcc ttgccgaggg 2921161 tgcttgttaa atctgttccg gaatagcgcg tggctgaaat atcaatgtca ccgcccagca 2921221 tcgcttggtg ctgaacatag tttgagccga ggtttttcac taaagcagta ttcaaatctg 2921281 tatcatgttc aataagctgc gcgatcatat tcgctacaat ttctgattct gtcatgctct 2921341 gcgccccgat tttgatcgta tcgtcagaag cgccgcctag acccggcaga gagcagccgc 2921401 ctagcagcat gacaaagacg agagcaaacg cgccaagcca tttgattttt gtcattttca 2921461 acagtgccaa ctccttacga tacttccttc atcccttgca agcctttcgg cgtcaccttt 2921521 cgttctgtca cagccagaac ataatcaata ataattgcca gaattgtgac aggcacggca 2921581 ccgccaatga tatattcagg ctggtatagg ttcagtccga taaaaatata gtccccgagg 2921641 ccgcctcccc cgataaacga cgcaagtgtc gcccagccaa ttaggtagat cgttgatgtg 2921701 cggatccccg ccatgatgat gggaatcgcc agcgggattt caacgagccg aatctgctcc 2921761 cagccggtca tgccaattcc tttccccgat tccaggaggt ttttatttac acctttaatg 2921821 ccggtatacg tattgcgcag gatcggcagt accgaataga aaaataaagc gacaatcgca 2921881 ggcacttttc ctacgccgag aagcggaata aaaaaggcta aaatcgccag actcggcagg 2921941 gtttgcacaa tgtttacgaa accgataacc gcacctgcgc cttttttcat tctggtaaga 2922001 gcaacgccga gcggcactgc aacgataatg cccaatacaa cggctatgag tgaaatatat 2922061 aaatgctctc ctgttttata cagcagctct ccgccgttcg tttgcaaaaa agtcatcatt 2922121 tgattcatct taaaagagct cctcccctgg tcagatcgtc atgagctggt tttcctcgtc 2922181 gccccaaatg gaatcgtata cgatatcaac gaggctcgct cttgtcacaa tccctgctaa 2922241 atggttctgt tcatcgacca ccggaacata cttgatcccc tgcttcaaaa tttttcggac 2922301 tgtatcgcga agaagcgccc ctttttgaac ggtatatata tctgaacggt atacatcgcc 2922361 aacgatgctc gcttttttgc ggttttgatc aatcatttcc acatcaacat agcccttcag 2922421 cacgttttgc cggtccacaa cgagcagcga gtcaacacgt ttttctctca tcagctgaat 2922481 cgcctgagaa agcgttttgt ccgcagatac cgtcaccggc gttctgttca tcatttgctc 2922541 tacccgctcg atatccggtc ttgactgaat caggcgctct ttcccgataa attcttcaac 2922601 aaactcattt gccgggtttc gaagaatctc atcaggtgtg ccgacttgaa cgatttctcc 2922661 cgcttttaat atcacaatcc tgtcagcaag cttaatcgct tcatccatat cgtgggttac 2922721 aaacacaatc gttttgttta aggttctctg cagttttttg aattcttcct gaagggaatc 2922781 acgcgtaatc ggatcaagcg ctccgaacgg ttcatccatt aaaatgagag ggggttccgc 2922841 tgccagggcg cgcagcacgc cgattctctg ctgctgtccg ccgctgagct catgcggata 2922901 acggtctaaa tactctgggc ccatatccac aagctttaac agctcgcgcg cccgttcttt 2922961 ccgtttttcc tcaggccatt tcagcagctt tggtacgagt gagatgttct gctggatggt 2923021 catatggggg aacaaaccaa tctgctgtat cacatagccg atttttctcc tcagctcaac 2923081 cgggtcctgt tccataatat tttctccgtc gataaagatc cttccagacg atggttctat 2923141 cagtctgttg atcatcttca tcgtcgtcgt ttttccgcag ccgctcgggc cgataaaaca 2923201 gataaattca ccttttgcaa tatctaaatc aatgctgttc acagcttttt tgccgccttt 2923261 atatactttt gacacttgtt ccaatttcag caatccgtgc acctccgcag gtttccttta 2923321 aattttctga aaagtataat ccttattata gtttgaactt tgtaaaataa aaagtttaca 2923381 atgtgttgaa attatatgtt atttatagat tatttattgt tatgaccgag acggaaaggg 2923441 tgttcttaca attactccgg atacctccca cttcctctgc attcagctat tttcaacacc 2923501 aggaagaaat atgatatatt gacaccatca attgccattt gaagggatga tcagctgtga 2923561 aaaaaaccgc tctcgacatc attgaacatg ctgaagagca tctcattgag aagattgccg 2923621 aaaatatgca tacgtttgga atgccttcaa ctgtcggacg tgtgctcgga attatttata 2923681 tgaatcgaaa accaatgacc ttaagcgagc tctctgaggc aacgggcatg agcaaaacac 2923741 ggatgagcca ggttgtccgg gaaatgatcg atgccaatat cgccgaaaag gtgtttgaaa 2923801 aaggcgtacg aaaagacctt tatgacgtcg agcaggatta ttatcaaacc ttcatttctt 2923861 tatttgcggc gaattggaca aaggtcgtga gcaaaaacaa agtgctgtat aaaaaattaa 2923921 accgggagct gagtgatctt ttacaaaggg acgggcttac cccggaagcg gaagagaaag 2923981 tcaatcagct gctgaatgaa ttaaaagaat ggcttcatta ctatgattgg ctgagcaggt 2924041 tgattgaatt ttttgagagt gaggaagtct ttcggtatgt gccgaaaaca aaagaatgca 2924101 gctctctaaa ataagagagc tgctttttgc atcatgaagt taagaccgga aacatgcctt 2924161 tcagcccggc accaatcatc ccgaccgcaa ccacggctaa gattaatccc atcagtctgg 2924221 taatcacatt catctcggtt tttccgagtt tgctgctgat aaaagcagaa tagtggaaaa 2924281 agagaaaggt cagggcaata acggcggcta tgccgatcat gacagccgca taatgaccaa 2924341 tgccgctatg tccggcggaa aggctcatca ctgttgcaat cgttccgggc ccagcaatga 2924401 tcggaatgga taaaggtgtg actgatatat ccgctttttc cttgctttcc ttatgttcat 2924461 catggtgaag agattgcacg tgcgattctt tcgcattcaa tagattatag gcaatgccga 2924521 aaatgaatat gccgcccgcc actcggagcg cgtgaatgtt gatatcaaac agtttaaaga 2924581 taagatgacc gaaaaccaaa aaagctgcga gaataaaaaa ggataaaata gctgccttcc 2924641 gggcaatcgc ttttctttcc gctgcagtat agccttctgt cagcgtcaga aatatcggta 2924701 cgtttccgat cggattcgat actgcgaata aagaaatgaa gacgtgaacg ataaatgaga 2924761 acatcatata cctccttgtt gatagtctct gcacaggaaa tagaatgatt ctccaccctt 2924821 ttacccggag gcgatttccc ggtaaacctt tatagcctgt cagaaacgcg ccatgctaca 2924881 atgaagtgac aaattgaata ggaaggacgt atacagatgt tcaaaaaaat tgcggcagat 2924941 gccttgggct tatctgatat cggaaaaatt atcgaacctc aggactatga caaaacagac 2925001 gcagatgact atgtcatgca tgaagataat gagaaaattt atttcttgat taaaacaaaa 2925061 gcagacgagt attgctttac gaacctggcc ctgatccatg tggacggcga acgcgccact 2925121 tcctcaaaac gaacgttgaa acgctatcct tattcgcaat ataaaatctc tgacgttttt 2925181 cttgaaactg ccggaaaagt ggatttggat gttgaaatta agttcaagct gggcggtgaa 2925241 caattcgaca ttgatgtcca caaagaccag attgaaaagt taaaagacct ttataaagca 2925301 ctgcttcgca tcgctgaaac aacctatgaa aatgacattt taatcaatca agcggagcaa 2925361 agcttagata aagcagtgac gattcttcac catacccgcc ctgagcacgt caatattgaa 2925421 acgcaataca aagagctgac cgaattcgga ttcacttggc tgacatccgt tcgctcgcag 2925481 tatcatatta aggattttgg ggatgtattt gagaaatata ttaataacta gataaaaaaa 2925541 gacacagctg ctatcgtgct cgtgtctttt tttgtatgaa tattgattac tttacaactt 2925601 ttttctttta taataaaact attagtctat tttccctata ttacagataa aggagttatt 2925661 ttatgtattg tcctcaatgc ggccatcaaa cagatggcgg aaatttttgt gagaaatgcg 2925721 gatcaccgct ccccggtcaa tcaggccacc agcatgcagc tcaaactgga gccgctgcaa 2925781 agcaagcagc aaaacagttc ggttcatttg tcttatccgt cctgaaacgc ccttatcagg 2925841 aatgtaaagc aacaggcgga gaacagctga tcagcgcaat cattacgatg gttcttttca 2925901 gtttgctgac ccctttgatg ttttatattc ttttttcaga cggtcccgga agcgtaagct 2925961 ttacagcaat cttcttagag ccaaccattt attttatttt atttctattt ggcctgcatg 2926021 catgcatctt tttcgccctg aaaatcgcgg gaaaccaagt gtctttcaag gattcattct 2926081 caagattcgg agcatttctt attcctttta cggctatttt gattcttgcc cttttcttct 2926141 ttttattaca tacagacatt tgctttacca tattagccgt tggtttaatc ggtgcattct 2926201 tcgccattcc tcctgcgatg ctgagcagtt accagcattc atataaaggg aaggttgatt 2926261 tcatttactc aacgattgtg atttatctga tcatctgcgt tacatttcag cttattatcg 2926321 aacactatgt caaagaaatt ttccgttata tgctctttta aaaacaaccc catcacctgc 2926381 tggtgatggg gttgttttat tgaatagacg ttaagtaaat tcttccgttc ttcactacgc 2926441 cggtgtaggt ccagttatat gttctgagct ttggactgcc gcctgatttt gtgatataga 2926501 attcttcata cgtcttaatc gtgatagccg acccattttg gctccagctt ttcacttcat 2926561 agttattaaa gtcttctgtt gtcccctctt tatttaattt cgacacgaga tgctgctggt 2926621 cggaataaag ggaactgcct ttttcaaggc tgtcttccat cagtgagaaa ttattttgat 2926681 tcacggcatc tgcctgactt tgcagataac tgcccataaa taatgtcact tgttcatctg 2926741 taacatcgcc gcttgcagag ctttcactgc ctttgttttt cgagccagcc caggcggaag 2926801 tgtatgtctc tggtttatca tttttgattt tctttatatt tgtgcctgca gattcgaatg 2926861 ttgattctgc atcttcgaaa atccactttt tctgtttttt atcatatgaa agaagatatt 2926921 cataactcgg actgtcgtca gtcatttcag actttgtata gtcgttatac gaagaagact 2926981 ggtgaagttc ttttcctgtt accgatacct gccacgttcc gtcgtttttc tgagagaggg 2927041 caaatgtgtc caggtcaaaa tcagtttcca agtatctatc ttttaagtat gaatccgcgc 2927101 ttttcataga atcgacggtg tccttcgtct ccgccttcca attggcactt gcctctgtca 2927161 tctgggctgt attcccatca gatagagctt tggagtattg ttttgttgtt ttgacaattg 2927221 tgttcataat ctgttcctgt gtatcttgat caggaattaa cgttaactcc atttctttat 2927281 catcgatcgg aacgccggca gtttttgttt ttccccacgg aaattctgcc tcgactgaag 2927341 ctgtcattga tccatctgtc agcagcggac catatgttac ggatttgaac ggatctttat 2927401 gaattgattt accgttaatc agcaaatctc ccttcccgct cttgatgtca ttcgctaagc 2927461 tgaatgtcac atcgtctgct tccaatgaga gatcaacacg aaagctgcta tcgccaatcg 2927521 cctgaatgtc ttcctttttc acaaggtcaa cgacatcgtt tttcagtttg gctgagactg 2927581 tatattcgcc gggaatgtac ggaccaaggg tttgtgcttg atctgctttc tttacagatc 2927641 cggcttcctc tttattgaca tatagatcgg tatttttata attgctgctc acttcaaaat 2927701 aaacaggtgc tacctttaag tcataatggt caaataccag caggcttttc ccgtcttttt 2927761 ccgcatatac gatatccttc tgggctgttt catcacgcag cgatgcaaaa agttcatctt 2927821 ttttgtctgg atgatccttc aaatatgtaa gaaacggttt tacattattt ttagtgagtt 2927881 taagattgtc atttaccggt gtaagcagag tcgcgatttg gtcctgatcc ccatcattta 2927941 cggcctgttc aaacttgtct actaacctat cctttgaagt aaaatacgct ccggttttat 2928001 atgcggcgaa taatataacg cacgccgcgg caatgctgct ccataaaatg atggttttct 2928061 tagggatcgg ttttcgcgga gcctgcctcg tttctgcagt gctagctgtt tcttgatttg 2928121 cctgtttgct gccccctccg atcggggtgc cgcattgttt acaaaacttg gctccttcat 2928181 tattctggga gccgcaattc ttacaaaata acatgacttt cctcctattc tactaatttg 2928241 ataacattta ctgcttttca tattttataa taaaacagaa tgaaattggg aacgaatgaa 2928301 aaaattaaat gtctatcaga ctaaaaaggt ggaatgaata tgcaaaagct caggattgaa 2928361 ttaggagaag aaacaaatga cgaattatat gatctattgc tgctcgccga tccatcgaaa 2928421 gacattgtag atgaatatct tgagagggga gaatgttaca cagcttgggc cggtgatgag 2928481 cttgcagggg tttatgtatt gctaaaaaca aggccgcaaa cagttgaaat tgtaaatatt 2928541 gcggtaaaag aatctcttca gaagaaaggc tttggcaaac agcttgtact tgacgccatc 2928601 gaaaaagcga agaagctggg ggcggacacg attgaaatcg gaacggggaa ttcgagcatt 2928661 catcagcttt ccctctatca aaaatgcgga ttccgcattc aggcgatcga ccacgatttc 2928721 tttctcagac attatgatga ggacattttt gaaaacggga ttcaatgccg cgatatggta 2928781 aggctttatt tggatctctg aaagcataaa aaagccgccg agagaaaatc ccggcggtct 2928841 ttttattact tgtttaagtt gtagaaagag ttgataccgt ggtattgagc agtttcagcc 2928901 aactgatctt cgatgcgaag aagctggttg tatttcgcaa cacggtccgt acgagacgga 2928961 gcacctgttt tgatttgtcc tgcgtttgtt gccacagcga tgtcagcgat tgtgctgtct 2929021 tcagtttcac cagaacggtg agagataaca gctgtgtagc ctgcgcgttt cgccatttcg 2929081 atcgcatcga atgtttcagt caatgtaccg atttggttta ctttgatcag gatagagttg 2929141 cctacgccgt ttttaatacc ttcagaaagt tttttcgtgt ttgtaacgaa gaggtcgtca 2929201 ccaacaagct gaactttttt gccaagacgc tcagtaagaa gcttgtggcc ttcccagtcg 2929261 ttttcgtcaa gtccgtcttc gatcgagatg attgggtatt tagaaacaag ctcttcatac 2929321 cagtcaacca tttcagcaga tgttttcaca acgccttcgc cagacagatg gtatttgccg 2929381 tcttctttgt tgtagaactc agaagatgca gcatccatag caagtttaac ttcttcgcca 2929441 ggtttgaagc cggctttttc gattgcttca acgattgttt gaagcgcttc ttcgttagaa 2929501 ccaaggtttg gagcgaatcc gccttcgtca cctacagcag tgtttaagcc ttttgcgctt 2929561 aatactgatt tcaggctgtg gaagatttga gcgcccatgc gaagtgcttc acggaagtta 2929621 ggagcaccta caggcatgat catgaattct tgaatatcca cgttgttatc agcatgctct 2929681 ccgccgttta cgatgttcat catcggtaca ggaagcgttt ttgagttgaa tcctccaagg 2929741 tattggtaaa gaggaatctg taagaaatca gcagcagcac gcgcacaagc catagatacg 2929801 ccaaggattg cgttcgcacc aagtttgcct ttgttttcag taccgtcaag ctcgattaaa 2929861 agctgatcga ttgcgttttg ttcagttaca tcaaagccaa gaagctctgg agcaatgatt 2929921 tcgtttacgt tgttaacagc tgttaacacg ccttttccaa ggtaacggtc tttgtcgccg 2929981 tcacgaagct caaccgcttc gtattcacct gtagaagctc cgcttggcac taatgcgcgg 2930041 ccgaaagctc ctgtttctgt atatacttca acttcaactg ttgggttgcc gcgggagtct 2930101 aatacttcgc gtgcataaac atcaacaatg tatggcatga gttttgtctc tccttttgat 2930161 tttcaaatta tttttgaatt aaagatgttc ctgtcatttc tttcggtttt tcaacaccaa 2930221 gaaggtctaa taacgttggt gcaaggtcgc ctaggattcc gccttcacgc agcgtaatgc 2930281 cttctttcgt tacaatcaca gggactgggt ttgttgtatg cgcagtgtgc ggttcgcctg 2930341 attctgtaat cagaatgtca gcattaccgt gatcagcggt aatgatagcg tgtccgcctt 2930401 tagcaaggat cgcgtcaacg acttcgccca agcattcgtc cactgcttca attgctttaa 2930461 ttgttggttc aaccattccg gagtggccga ccatatcagg gtttgcgaag ttaagaatga 2930521 tcgcgtcatg cttgtcagct tcaatttctt tgacaagcgc gtctttcact tcatacgcac 2930581 tcatctcagg cttcaagtca tacgttgcaa ctttaggcga gttgatgaga atacgctctt 2930641 cacccgggaa ttcagcttca cggccgccgc tcataaagaa cgtgacgtgc ggatactttt 2930701 cagtttctgc aattcgaagc tgttttaacc cgtgctgaga taatacttct ccgactgtgt 2930761 tatcaagatt tatcggttta aacgctacat agccgtcaac tgtttcactg aagtgagtca 2930821 ggcagacgaa atacaggttc tttggataat tctcgccgcg gtcgaagtca cggaagtctt 2930881 tgtttgtgaa cgtgttggaa atctggatgg cgcggtccgg tctgaaatta tagaaaatca 2930941 cagaatcgcc gtcttggatt ttcgcaacag gctcaccgtt ttcttttgtg atgacagatg 2931001 gaatcacgaa ttcatcgtag ataccatttg catatgaatc atcaacaaca tccagggcgc 2931061 tgcggtaaga tgggccttcg ccgtacgcca ttgcgcggta cgctttttct acacggtccc 2931121 agcgtttgtc gcggtccata gagtagtaac gtccggaaat gctggcgatt tcacctacac 2931181 cgatttcctt gatttgatcg ttcaactggt tgatgtacgt tttcgctgtc tgcggaccta 2931241 catcacggcc gtcaaggaag ccatggatat aaacctttgt cagcccttct tttttcgcaa 2931301 gctttaacag tgcgaataaa tgattgatat ggctgtgcac gcctccgtca gataaaagac 2931361 cgaacaggtg caaggctttg ttgttttctt tcgcgttgct gatcgcgtca aggaatgttt 2931421 gattgcgttc gaactctcct tcacgaatgg caacatttac gcgtgttaag ctttggtaca 2931481 caatacgtcc cgcaccgata tttaagtgac ctacttcgga gttccccatt tgcccttcag 2931541 gaagacctac agcctcgcct gaagcagtca aagtttgatg aggatactgg ttccaatagc 2931601 ggtcaaaatt cggttttttc gctaaagcga ctgcgttccc tactgtttcg ttacgtaatc 2931661 cgaacccatc aagaatgatg agtgcagctg gttttttact catattgacc ttcctccaat 2931721 aattgaacga atgactgtgg ctcaaggctc gcgccgccga ccaaagcacc gtcaatatcg 2931781 gactctgcca tatattcttt aatgtttgca ggctttacgc ttccgccata ttggatgcga 2931841 agcttgtctg cagcttcttg gctgaagctt tcagcgacgg ttttacggat atgcgcacac 2931901 acgtcattcg catctttcgc tgtagaagat ttgcctgttc cgattgccca gattggctca 2931961 tacgcaataa cagaagcagc aacttgttct tcagaaagac cagcaaggcc ttttttcact 2932021 tggtcagcaa caagatcatt tgttttgccg gcttcacgct cttcaagcgt ttcacctaca 2932081 cagatgatcg gcacaatgcc gtgtttgaaa gctgcgtgtg cttttttgtt aactgtttca 2932141 tcagtttcag cgaacatttc acggcgctca gagtggccga tgacgcagta gtcaacgcca 2932201 aggtctttca gagcaaccgg gctgatttcg cctgtgaacg cgccgctttc ttcgaagtgc 2932261 atgttttgag cgccgacttt taggtcagtg cctttcacag cagaagcaag cttttctaag 2932321 aaaagcgctg gcgcgcaaac aacagcttca gctttgtctg ctgctggaat ggaagatttc 2932381 acttcttcaa cgaagctgac agcttcgccg agtgttttgt tcattttcca gttaccggcg 2932441 ataattggtt ttctcatctg ttccacttcc ttatagcagt tttgagatta tttatcgttc 2932501 agtgcagcta cccctggaag ctctttgcct tccataaact caagggatgc gccgccgcct 2932561 gttgagatgt ggctcatttt gtcagcaagg ccgaattttt caaccgctgc cgcagagtct 2932621 cctccgccga tgacagagta tgtatctttc gcctctgcca atgcttccgc aaccgctttt 2932681 gttccttgag cgaacaagtc gatttcgaat acgcccattg gtccgttcca cacgacaagt 2932741 ttgctgtttt tgatgacgtc agcatacgtt tcgcgtgttt tcgtaccaat gtcgattgct 2932801 tctaaatcac tagggatttc agagatcggc acaattttca cgtttgcatc gttagagaaa 2932861 tcatctgcaa cgagtacatc ttcaggcatg tagaagttaa cgcctttttc tttagcgcgg 2932921 tccataaatg atttcgcaag ctcgatttta tcctcttcaa gaagagattt cccgacttca 2932981 tagccaagcg cttttacgaa agtataagca agacctccgc cgatgatcag gttgtctact 2933041 ttatcaagaa gactttcgat tacaccgatt ttgtctttta ctttcgctcc gccgatgatc 2933101 gctgtgaacg ggcggtcagg attggaaacc gcttttccaa gtacatcaag ctctttttcc 2933161 attaagaaac ctgcaactgc tggcagatgc tcggcaattc cagctgtaga tgcgtgagca 2933221 cggtgggcag caccgaatgc gtcatttaca tatacatctg caagctcagc aaatgctttt 2933281 gcaagctcag gatcattttt ctcttcacca ggatagaaac gtacgttttc caatacaaga 2933341 acgtctccgt ccttcatctc agaaatttgt gcttttacag catcgccgta tgcttcatcc 2933401 gcttttttca cttctttgcc aagcagttcg ccgagacgtg cagcgacagg agttaaacga 2933461 agctcctcaa ccacttcgcc tttcgggcgg cctaagtggc tcgcaagaag gacttttgcg 2933521 ccttggtctg caaggtgttt gattgttgga agcgcagcac ggatacgtgt atcgtctgtt 2933581 acttccccgt ctttcattgg aacgttaaag tcaacgcggc agaatacaac tttgcctttt 2933641 acgtcgatgt ctttgagagt ttttttattc atgcctagga gatcctcctt caaaatggtt 2933701 tgcatacagc acgaaaaacg tgaaaccgtc tgttcaagcg ataactccgc tagggcagat 2933761 cgcagtcttt ttcggcacag ggcagttcgt ctaaaagcca gggcagcggc cttaggcgaa 2933821 agcgccggca aagctgctta aaacgcggtc gtttctctat cacagagcgt tttctgaaag 2933881 ccggtcttca tggaaaaagg gaaagggagt ccgtcccctt cccttgtccg ctttcattat 2933941 agcgcttcta ttcgaaagaa ccaagtcagg tcctttttca gctataaatt aaagaccttt 2934001 ttttgcgatg taagctgcaa ggtcaacaac gcggttagag tagccgcttt cgttatcgta 2934061 ccaagagatt acttttacca tgctgccttc cataaccatt gtagaaagag catcgattgt 2934121 agaagagttt ttgtttccgt tgtagtcgcc agaaactaat ggctcttcgc tgtagccaag 2934181 gattccttta aggtcgcctt cagccgcttc tttaagagct gcgtttactt cttcagctgt 2934241 tacttcttgg ttcagttcag caaccaagtc aactagagaa acgtttggag ttggaacacg 2934301 cattgctcca ccgttcagtt tgccttttag ttcaggaaga actagagaaa ctgctttagc 2934361 agcaccagtt gatgttggga tgatgttttc agctgctgca cgcgcacgac ggtagtcttt 2934421 gtgcggaaga tcaaggattt gctgatcgtt tgtgtaagag tgaacagttg tcatcatacc 2934481 gcgtttgatg ccgaatttat cgttaagtac ttttgcaaac ggcgcaaggc agtttgttgt 2934541 gcaagatgcg ttagagataa catcgtggtt agccgcatcg tatttatctt cgttaacacc 2934601 cataacgatt gtgatatctt cttcgttagc aggagcagag atgattactt ttttcgcgcc 2934661 agcttctaag tgtttcgcag cgtctgcgcg ttttgtgaag aaaccagtag attcaactac 2934721 gatttcaacg ccttgtttgc cccagctaag tttagcagga tcgcgttctg cagaaacttc 2934781 aattgttttg ccgttaacaa caaggttgtt accgtcaact gaaacttcag cgtctaattt 2934841 tccgtgtaca gaatcatatt gtaaaaggtg agccagcatg ttagcatctg ttaaatcgtt 2934901 aaccgctact acctcaactt caggattgtt taatgctgcg cggaatacgt tacgtccaat 2934961 acgaccaaaa ccgttaatac cgacttttac tgccatgatt gtttcctcct ttaaataagt 2935021 gagagatatt tatattgagg gattattcat cccttaataa cttctttgcg gctccttcgt 2935081 ctgtgacgag aaccgtgttg cgtggctttt taaagtaagc ctcgatcgct tcggcttttg 2935141 atgatccgcc cgctaccgca ataatatcgg ggatggcgtc tatgtcatcc agctgcattc 2935201 cgacagaatg cactttgtga accacttcgc cgtccgcgtt aaaatagtag ccgaacgctt 2935261 ccgtcaccgc gtcgttatca tctattttct ttaaatcttc taaaggcgtg tttctgcgct 2935321 gagccatagt tttagcttcg ccgattccgt gaaccagcat actcgctgat ttaatggtgt 2935381 tcagcacctc tttgacagaa ggctcttcaa taatagatga ataggcgcct tgtgacagct 2935441 gtcccggaac aaacaaaagc cggtaagtgc ctgaagcctt ctccgccata tgcgcgcata 2935501 tggtgttcgc ctggtttttc acgtcttcgc ctaaaccgcc tcttgcaggc acaaacaaaa 2935561 gctcgcggtt tttagaatcc ggcgtcatca tttcggcgac agcttcaatt gtcgtaccgc 2935621 cagttacagc gacgatattt ttgcctgaaa atcttttttt catacatgcg acagccgctc 2935681 ttcccatttc ttttttgacc catggggatt gatcgctgtc tccggatacg ataatggcat 2935741 cctttagatt taaacgttct tttaatgtct tttccaaaag agtcaaacct aaaacatctt 2935801 tcatcgtatc ttccaaaaca gaaagcagtt catagccctc ttctgtcaat gtcatgccgt 2935861 ttgtcttaat atcgaccagg ttctgttcct ttaaaaactg aacctcgccc ctcagcacac 2935921 gctcgctgat tccgagactg gcagacaggc ttcttcgccc gatgggttct gtcagcctga 2935981 tatactgcaa gatttcaaac ctcttttgca taacgagcag aagatcaggc aataattttt 2936041 tttgagcttg tattaactgg ttcatgactc aaacgttcct tccttttttg ctggacatta 2936101 tatgtcccgc tatgacaaaa aacgtcccgt catagccaaa aaaaatcatt tctgctttct 2936161 ttaattattt taacagggtg gaattgttta ttcaactgtt aagagccaat tcatcgacaa 2936221 tattcgcaga gttttcatgc cgcgtcgttt tatccagcaa tattttatcc tatatatctt 2936281 tatcttatac agaaagcgcc aaatggtgca tcccaatata aacagccctt cccgtagaaa 2936341 gggctgtttc attaaagcgt tttcatttta tccaaagctt ttcaatttcc tcgagcgatt 2936401 tgttcttcgt ttctggacag atcgtaacga caaacaggaa acaaaggatg ttaatcaccg 2936461 caaagatcca aaatgtatag gcgagcccga aagaatcgat catcattggc acaaactgtc 2936521 cgatcgccca gtttgctccc cataaaaaga tggtcgcaat gcccgcggcc cgcgcacgca 2936581 gatggttcgg gaagatttca gaaatcataa tccatgtgat cggtccgacc gagacacaga 2936641 aagcagcgac aaaacctaat ataaggacga tcatcatgat cccgcttgtt aactcaaaat 2936701 aaaacgacgt cccgattaaa atcataaaaa tagccataaa agcagaaccg atggacatca 2936761 gtttttttcg tccgacttta tcaatcagca acaccgcaat aacggtaaaa ataacttcta 2936821 caaccccgac gatacaagtc gtcacaaatc cggcgttttg cccgaatccc atcattttaa 2936881 agatttccgg cccgtagtaa gtaatcgcgt tcatgccgat gacttggtta aacagcgcca 2936941 gcaggattcc aatgacaagc gcctttctga gacccggctt aaacagctgg gagagcgacc 2937001 ccatttgttc tatttttaaa gagttctcaa tgttctttaa ttcttctttt gcaacagttt 2937061 ctccattaat acgtgtcagg atctttaaag cttcatttgt tttgcccgct ttcgccagcc 2937121 atctcggact ttccgggacg acgagcagga caaggaaaaa aatgacggat ggcaccattc 2937181 cataagcaag catccatctc cagccggtgt gcacgcccca ttcgtatgtt ccggaccgct 2937241 gcacagctag attaataaag tatgttgcgg aaatacccag tatcgtaaag agctgatata 2937301 acgaagataa acttccgcgt atagcgggcg gtgccgcttc tgtaatatac gtaacagaga 2937361 gcgatgagcc catcccgatt cccagccccc cgataatcct tgcaatgatt aaggtggaca 2937421 cgtcttgaga aagcgctgaa acgattgctg atatcgcaaa taacaaagcg gctgtcatta 2937481 aaatttttct ccggccgaat ctgtcactta aaaatccgga tatcccgacg cccacaactc 2937541 ctccaatcat aatgcttgaa atgacaagtc cctccataaa cggactcagg ctgtataaat 2937601 ctttcagaaa accgatggcg ccagaaatca ctgccgtgtc atagccatac aataagccgc 2937661 caagccccgc cgcacatgag atcaaaatga caaatcccat tgaatggctt cttgttacag 2937721 gaacatttgg ttctaattga gttggagtat tcttcatttc cctgccctcc cgaatgttga 2937781 gtaaagcgtt ttcatttaaa ccttcaattg tacgtactta tattaaaatt taacgaaaat 2937841 tacatttaat tagtacgtac aaatatagaa taatcttgtt tgcattttct gtcaatgttt 2937901 tcttacaaag aacgctgtga tatactgaaa tttgtccgta tacattttgg aggaatggat 2937961 atgttaccaa aatacgcgca agtaaaagaa gaaatcagtt cttggattaa tcaaggcaaa 2938021 atactgcccg atcaaaaaat ccctaccgaa aacgaattaa tgcagcaatt cggcgtcagc 2938081 cggcatacca tccgcaaagc gatcggagac ctcgtatcac aaggtctgct gtacagcgtg 2938141 caaggcggag gcacctttgt cgcttcacgc tctgctaagt cagcgctgca ttccaataaa 2938201 acgatcggtg ttttgacaac ttacatatca gactatattt tcccgagcat catcagagga 2938261 atcgagtcct atttaagcga gcaggggtat tctatgcttt tgacaagcac aaacaacaac 2938321 ccggacaatg aaagaagagg cttagaaaac ctgctgtccc agcatattga cggactcatc 2938381 gtagaaccga caaaaagcgc ccttcaaacc ccaaacatcg gctattatct gaacttggag 2938441 aaaaacggca ttccttttgc gatgattaac gcgtcatatg ccgagcttgc cgcgccaagt 2938501 tttaccttgg atgatgtgaa aggcgggatg atggcggcgg agcatttgct ttctctcggc 2938561 cacacgcata tgatgggtat ttttaaagct gatgacacac aaggcgtgaa acggatgaac 2938621 ggatttatac aggcgcaccg ggagcgtgag ttgtttcctt ctccggatat gatcgtgaca 2938681 tttacaacgg aagaaaaaga atcaaaactt ctggagaaag taaaagccac actggagaaa 2938741 aacagcaagc acatgccgac agccattctt tgttataacg atgaaattgc gctgaaggtg 2938801 attgatatgc tgagggagat ggatcttaaa gtgccggagg atatgtctat tgtcgggtac 2938861 gatgattcac atttcgccca aatctcagaa gtgaaactaa cctctgtcaa acatccgaaa 2938921 tcagtgcttg gaaaagcagc cgccaaatat gtcattgact gcttagagca taaaaagccg 2938981 aagcaagagg atgtcatatt tgagcctgag ttgatcattc gccagtccgc acgaaaactg 2939041 aatgaataaa aaaagcaatg tatgggtctc cccgctacat tgcttttttt atagctgtta 2939101 tctgtttttc caaacgtcag cgatgatttc aaacgaacgc attctgtctg cgtgttcaaa 2939161 ggtttctgag ttaaccataa tttcgtcagc ctgtgtcgtt ttgacgaaat cttcaagctt 2939221 cgccttcact tcttccggac ctccgacaat cgtggagctc agctgctcat tgaccatcgc 2939281 tttttcatac gggctccaga tttggtccat atcctcaaca ggcggtttaa gctggttagg 2939341 cgtaccgcgg acaagatcaa gaaacctttg ataatgggaa gtcgcaaggt gctgcgcttt 2939401 ctcgtttgta tctgccgcga taatggtgac accgaccatc gcatacggtt cgtcgagcac 2939461 gtctgacggc gtgaaggaat tgcggtacag ctccaaagcg ggaaccgtat tcgccggtga 2939521 gaaatgggcc gcgaacgcaa acggaagacc aagttcgcca gccagacggg cgctgaagcc 2939581 gcttgagccc agcagccaaa tcggcacatc tatgccctct ccgggaatgg cgcgaacttg 2939641 attgcgcaca tttcctgacg gtttaaaata attgcgcagt tcctctaatt gttctggaaa 2939701 atcctccccg ctgttgatgt ttctgcggag cgctctggct gtcaattggt ctgttcccgg 2939761 cgcacgtcca agccccagat caatccgccc gggatacagt gtttccagtg tgccgaattg 2939821 ttcagcaatg actaatgaag agtggttggg gagcataatg ccgccggaac cgacgcggat 2939881 tttcttcgtg cctccggcaa tatggccaat caaaactgcg gtggcagagc ttgcaacacc 2939941 ttctatatta tgatgttcag caagccagta acggtgatag ccccattcct ctgcccggcg 2940001 cgccaagtcc atgctgtttc ggaatgattc tgcaatcgtt cctccctgaa caaccggaga 2940061 taaattcaag acagaaagca aggtatcttt gcgttggttg ttagacatat tgttctcctt 2940121 tgcaaatgtg ttatcagtaa acagcccaaa gctgtcaggt catgattgaa agaacttcta 2940181 tcacaccata acacaactgc attcaggaat aaaagaattt gattcgatga aattcgaaca 2940241 atataaaacg aacggtttgg aacattattc tgctccaaac aactccttag ccatctcaat 2940301 aaagagctta gccgccagag aagcctcctt tagcgacgga acagcaagct gcacatcacg 2940361 gtatacctgc gggtccaatt ccctggtcac cacatgctct ggcagcggca tccccgacat 2940421 ggacatttct gataaaatgg ccaggcccag gccttctctg atcatactga tcgaggtgtt 2940481 gatgttatag accgtgaaag ctgggtgcag cgtagcaccc gcctgcctga acatatcgat 2940541 aaatggtgat tcatagccgc cgtcacagac gatcatcggt tcatggtcaa gatctttcag 2940601 cgtaatggct gaatgactgg caagcgggtg atcgtccctg agcacgacag ccattttgtc 2940661 ttttttcaaa tgaatgtact ccatctcctc tgttggatac agaagaatcc caacatctat 2940721 catccgcgta tgaagccact ccttgacttc atttacagtt ccctcgtgca gcacgagctc 2940781 aagtttcgga tatttttgtt taaattcact gatcagcttc ggcataaaat aagccgaggc 2940841 agttgagaat gtgccgatat ggatcgttcc cagttcaagc cctttttccg ctgctgctac 2940901 ctgctcaact ttttcaatgc cttttaagac ttctctgatg tgtactaaga tctgttttcc 2940961 cgtatccgtc agcatcaggc cattgcggcg gtcacgaatg atcagcttta catcaagctc 2941021 agcttcgatc gcagaaatcg catggctgac agccggctgt gtcatgttca gcgcctgacc 2941081 cgcttttgta aagcttcccg tttcagctat tttcacaaaa acctttaatt gagtaatggt 2941141 cataacaatt tacttatgct ccttataaaa aagattcatt ttatttatct tatgttctac 2941201 cgtatcatat gatggaaaag ttctacaagg agtgaatgaa caatgaagca gctcccaaaa 2941261 acgcggacag ctctcctgct cgcatttctc gtcatcatgt ggggcgtcaa ttggccgctg 2941321 tccaaagccg cgctcgccta ttctccgcca ttattgttcg cgggcatccg aacgctgatc 2941381 ggcgggcttt tattagtcat agtcgcactg ccgcgtattc ataaattacg cttaaaagaa 2941441 acgtggccga tttatcttgt ttctgctctt ttaaatatta cattattcta cggcctgcaa 2941501 acgatcgggc tgaattatct tccggccggc ctgttttctg caatcgtctt cttccagcct 2941561 gttctgatgg gtgtattttc ttggctgtgg ctcggcgaat ccatgtttgt aatgaaagtg 2941621 attggcctca tcctcggttt tgcgggagta gccgtcatta gtgctgcggg ctttggcggg 2941681 catatttctg tcattggggt tctgctggct ctcggctccg cagtcagctg ggcgctcggg 2941741 acagtatata tgaaaaaaac aggcagccgc gtcgattcca tctggatggt cgctctgcag 2941801 ctgacgatcg gaagcgtgtt tctgcttatc tccggctttt ggacagaaag cttttcggcg 2941861 atccaatgga cagctccgtt tattacgagc ctgctgttca tctccgtatt cgttatcgca 2941921 ctcggctggc ttgtcttttt tacgcttgtc ggttcaggag aagcaagcaa ggtcgcatct 2941981 tatacttttt tgattccgct catatcaatc gtggccagct ccattttcct gcatgaaccg 2942041 ctcaccctta gcctcttggc agggctgctg ctgattgtca cgagcatctg tctcgtgaat 2942101 acaaaatcaa aagcgcagaa agctgcggcg attggtataa acgagaaagc tgcacaataa 2942161 taaaaaccct cttgccggat gcggcaagag ggtttcttat ttactgatgc ttgcgtcctt 2942221 tgaccaaata tgcaactgta atcaaaaggt agatcgccgc agtaatgccg gtaatgacaa 2942281 ttgatgttgt catgatgacc ccgatcagaa tggcgagtaa tgccacaatc gcaaaccatg 2942341 tcgtgtacgg gaaccatttt acataatagg ccggtgtttc cgtttgctgt tttctcgatt 2942401 ttaaatgagc gaatccgatg atcagccaaa tgaataaaac ggtatatccc aatgatccca 2942461 ttaaataatt aaatgtttgg cttcctgcga acagagaaat caatacgcca atatagagag 2942521 aagaagtgca catcagaatc gcaaacatcg gtacgttttt cgatgaaagc ttcgagaaga 2942581 cctttggaag ccttccgtca cttgcctgtg tatacaaaat gcgtgatgat ccgtataaac 2942641 ctgaattcat agaagaaatg atcgccagca ggatgactgc attcatgata tgatccgcgc 2942701 ccggaatgcc taccatttta aagaccatca cgaaaggact ttccggaacg gaattgactt 2942761 ggttccatgg aatcaggctg acgatgatga aaaacggcag caggtaaaac gcgacaatcc 2942821 gtgtcagtgt gctgcggaca gctttcggga caaccttttc cggatttttt gtctctgcaa 2942881 gcgttacacc gataatttct gtaccgccgt aagagtagat gacgacaagc atcgccgtga 2942941 tcagccctgt gccgccgtgc gggaaaaatc cgccgtggtc tgtcaggttg gaaaatccgg 2943001 atgctgtatg atcaccgaat gatacaaata agagcagcaa tcccagaata ataaagataa 2943061 taataacggt aatcttgatc attgccagcc aatattcagt ttcggcgaag attttaacag 2943121 aaagcaagtt tacaatcgtg acgataagag aaattcctaa tgccaacacc cagatcgggc 2943181 agcccggcag ccaatattga atgaaaatcg cagctacaac agcttcagcc gcaatgttaa 2943241 gcacccacat tttccagtag atccagtcca aaaagtaagc agcgtaattt cccaatacct 2943301 gctggacaag atcacggaag gttctggcgt tacggtttcg aacagccatt tccgccagcc 2943361 cctgcataat aaacagcaaa ataatcccgc cgagcaggta tgcgataatg acagatggcc 2943421 ctgccacatc gatcgctgag ctgctcccct taaataaacc tgcgccgatt gctccgccca 2943481 gcgccatcat cataatatgg cgggacgtca tcgtgcgttt taacgtttga ttgtcgtttt 2943541 tcatcctctt ctacctctcc ttctcgtttt caaaaacaaa aaagcccgcc gtctcctacc 2943601 taatctaata gataaagaga cgacgagcct tcggctgacc gcggtaccac tcttgttgat 2943661 tcttcatgaa gaatcctgct tttgacctgt aacgaaggtt agccgttaaa acatagggaa 2943721 tattcaatct attccgttcc gtcttaccac tcccgggcga gttcaaagaa gaatcaggct 2943781 gcgtcgcacc accccgcagc tctctgttct gatcactttc ttttactgct cccaatctat 2943841 gtgttttagt tttctgaaaa actcaaattt tatgatctga atatattaac ataatatacg 2943901 tgcttctctt ttaactgtca ataacttcag agaaaaaaga aactgttatt ttgtcccttt 2943961 tcgaatggct ttccaaaagg attctgactc gtttcctaat gcgtaaactg aaacacctgc 2944021 tattttatat tgctttgcca gatggctttt cgtttgaacg gttttttcgt tttcatacca 2944081 cacgacatgt ttatgcttct ttttgtcaac ataagaaaac gtcatcgagc ctgatttttt 2944141 gttgaatgcc ggctttgctt tttgtttttt gatgagggat ttgagctcat tccattccct 2944201 tattgtgctg gtacttccgt cttttacatc ccagtcatag ccgtacgcag ggattcccat 2944261 gatgacttta ttggctttga tctttttgac tgaaaactgc agagagcttt tgatccagtt 2944321 tgtgcttgcc actgaccccg gctcacccca aatgccgtgt tcatcgtagg tcatgacttg 2944381 tacgaagtcg gcatatttgc cgattttcgc ataatcatac ggccagctcc agtcatcatt 2944441 tttatcatcg gcgcttttgg ccggaacgga taccattgtt ttaatatgtt tcttattcaa 2944501 agcctgtgag acatattgaa tgaagttcga gtatgcagcg cggtcttctg gatttactgc 2944561 ttcaaaatcg atattgattc cgtaatatga gtgctttttg gccagtgtaa ttaactgatc 2944621 tgtgaatcgt tttttcgctg ttttattgct catgacccga ctcgctaaat ctccgtcaaa 2944681 atcataaatg gcatcattat agtttgaaat gacagcccat gtcttgattt ttttcttttt 2944741 cgcatatgtc agctgcttag ttggggcatc gccaatgatt tgtccgtttt tttcaaacgc 2944801 aaatgtatcg gttgcgatgg cattcatgta tgtatgatat ttcgtaagag aattgtatga 2944861 agccgtatcc ccagtcgtgt agcctactgt cataccggct gccttcgctt ctccttttgt 2944921 atacataaac agaacaatcg caatcgccag tgaaaccgct atgatcagcc attttttcat 2944981 cgcatttcct cctgtatcaa gtcatactct tctcatcggc caaaaaattg gaagttgaag 2945041 ttttttcaag caaaaagccc ggcatatgcc tgccgggctt cctgagttca gcggtcagag 2945101 acgagaatat atgctgcctt tactggtcca tgcaccccca caactaaatc catttcaatg 2945161 tcggctgagt tactcggtcc ggtaatgtag ttgatacatg aaggaacagt gacaccgttc 2945221 gcaatgtttt ggcggatgat atcactggct tgtgtcattc tcggtacaat gcttgatttc 2945281 ggcacgatcg caatataagt cgttggcaaa aggctgacag agcggccgat gtcttttgag 2945341 gagaagagga caaccgtccc cgactcagcc aatgtaattt cgctgaatgt aatccctaca 2945401 ttggcttgct ccgctttttt aatattttcc tcgcctttgt cagcatccca ctcccagacc 2945461 ggcgttcctt cactcggcca gtccttggtg agcaggcttt tcagtccgta ttcttcaaag 2945521 cgggggtcct tcggaatgat gacagggcct ccagaaaagc ggctgacttg ctcgcgcagg 2945581 gcatcgtaaa ggccggttga atccgtttca atcagctctg tatggatttt gacacaatgg 2945641 tttttgagca ctgtgactaa gtcatccgct gaataacctt caagtgtttt atattgcggc 2945701 tgatgcgccc attcagggac tgccacgcct cctgttcttc gttcacggcc caggctggat 2945761 gcgattcggt ttaaaaagct ctcttgattc tgaatggttc ccttcgtcat cactgctcct 2945821 ccttcgtgcg ttcacttgtt tctctgtccg caaaccagtc tctgaatctc gatttatgcg 2945881 gtgccgggaa gtcgcgaatc tgggtccaat ttttaagcgg gccgggccct ttcgaaattt 2945941 tttcgtcctc tgtaaaaggc gtcatggcgg ccggcgccca ttttgagccc attttgtaaa 2946001 gcgataagga ggatgcgcca agtccgaatg ctttcattgc aagcttttca ctgatcggcg 2946061 ccctgccttc tttttcgacg atattctgac gatgcttgag tagcagctca tgaagcggga 2946121 ttttgaccgg gcaggcttct gaacaagcag cgcacagtga agatgcgtac ggcagctcct 2946181 tataatcgtc ataaccgccg agcaacggtg ataaaacagc tccgatcggc cccgagtaga 2946241 ttgagccgta tgaatgtccg ccgacatggc ggtacacagg acagacattg atacaggcgg 2946301 cacagcggat acattgcagc acagactgga attccgttcc aaggatattg gatcgtccat 2946361 tatcaacgat gacaagatgg aattcttccg gaccgtccac ttcaccttcc agcttcggac 2946421 ccgtcaaagc tgtaatatag cttgtcagcc gctgtccgac agcacttcta gtcagcatgc 2946481 tgactagcac ttcaaattca gaaaatgacg ggacaatccg ctccattccc atgacggtaa 2946541 tttgtgtttt cggcaaggtg ctcacaagcc gtccatttcc ttcattggtc acaaggctga 2946601 cggaacccgt gtcagcgatg gcgaagttac agccggtaat gccgatatcc gcttccagaa 2946661 actttttccg gagaatggcg cgcgcatgca tcaccagctc ttccggtttt tctgtatgtt 2946721 gatagtccag tctttcttta aacacatcgc gtatctgctc tttattttta tgaagagcgg 2946781 gcgctacgat atgtgacggc ggatcgtgat catcaatctg caaaatatac tcgccgagat 2946841 cggtttctac gacttcacag ccttccttct ccagcacctc attcagattg atttcctctg 2946901 tgaccattga tttagatttc acaattttct tcccgttctt cttttgaatg acatcccgaa 2946961 tataggaaga cgcctcttcc gctgttttcg cgaaatagac atgtccgcct cttttcgcca 2947021 cattttcggc aagctgtccg agatagaaat caaggttttc aaggacatgc tgcctgattt 2947081 cctctgataa tgagcgccac tcctcccagt ttcccagttc ttctgctgcc tctaggcgcc 2947141 gcgtccgcag acgctcctgt gcacctgaaa cagcgcctct cataaattca ttatcaatcc 2947201 cctgtgatac ccgctcttta aaagcgtcag taccgatttt catcgccatg atcctttccc 2947261 cctctgaatc cagttttatc tgctgttgag cacttcggcg atgtgcatca ctttgacatt 2947321 cttatctttt cggccaagcc gtcccccgat attcatcaaa cagccgcagt cagcaccgat 2947381 cagcacctct gctcccgttt cctccacaca ttcgactttt tcatcgacca tctgctcaga 2947441 aatctgcgcc atcttgactg agaacgttcc tccgaatccg cagcagttat gtttgcccgg 2947501 aagctctgta aactgcaggc ccttcacatg gctcaacagc ttcatcggct ccttccgaac 2947561 acccagcagc ctagtcatat ggcacgacgt atgtaaggtc gcttttgtat gaagggtcgc 2947621 gccgacatcc tctaccccaa ggacgttcac aataaaatct gtcagttcat acgttttatc 2947681 cgccagcttt ttcgctttat cggcccattt cggatcatcc tgaaacaggt gcggatactc 2947741 ccggaacatc gttgtgcagg aacccgaagg actgacaaca tattcggaat cctgaaacgt 2947801 ttcgatcatc cgtttcattg cttttttggc gtcatgtaca tagccgctgt tgtaagccgg 2947861 ctgtccgcag caaatctgcc cttctggaaa atcaacctcg cacccaagcc gctccagcag 2947921 ctcaaccgtt gcttttccga catttgtttg aaacatatca acaagacaag tgacaaaaag 2947981 tgagactttc atgatgaacc cctctctcat ccccaatata tgatcaggtc atctgatgac 2948041 ctgagttaaa ataactatat gaatatcgta cactattctg acaatggaag gaaagagttt 2948101 tctagggata ttttcatttg tggcatatca aaaacactcc cgatctccca ggagtgcagt 2948161 atatggttag atccagccct tttcctcagc gatgctggcg gcttctgtcc gatttttcgc 2948221 attaagcttt tggatgattt ctgagatata gtttcgaact gtgccttgag ataaatagag 2948281 ctccagcgta atgtcttttg ttgtcttgcc taaagccgca agcctcagaa tttcttgctc 2948341 tctaacggtt agcggatttt cgtctcgcat catattaaac gtcagctcag ggctgaagac 2948401 acgttttccc tttacacatt ttcgaatggc atcggccaga tcgtcaattt caccgtcttt 2948461 cagcagatag ccatgtgcac cggcctttac ggcgcgttca aaatatccgg ggcgggcaaa 2948521 ggtggttaaa ataatgacct tgctgacgca gccttttttc attaattcct ctgccacatt 2948581 cagcccgctt cgaaccggca tttcaatgtc cataatgcat acatccggct ccagcttcaa 2948641 aatagcatgt agcgcctctt ccccgtttaa tgcttgtccg atgactgtca tatcctcttc 2948701 taaatcaagc aaagatccca aagcgcctaa aagcattcgc tggtcctcag caataaacag 2948761 acgaatcatt cttttcgtcc tccaatcatt ctgctttttt aataagcgga atcgtcagtg 2948821 ccacaaccgt tccgttatgg tctgaaaccg ttaatccccc ttcaatgagc atgagccgtt 2948881 cttccattcc ccacaggcca ttcccaaaca ttttctcctt cggcgctccc tttccgtcat 2948941 cccgtattac gatcctcatt ttgtcagcaa attgagaaat ggtgatggca cagtgggttg 2949001 ctttgctgtg cttgataatg ttagtcacgg cttcccgcat acacatactg ataatatttt 2949061 gagtgacggg agatatcact gaaaagtcgt cggctccttc gtattgaaag gtaatgttcc 2949121 ccgctcttaa tatgtgctga atgtttacga gctcctctgt tatcgtgacc gttctcatat 2949181 cagaaaccag ctctcgaact tgcttgagtg cggagcgtga actggtttcc atttcttttg 2949241 cctcaagctt ggtccgttct ggatcagatg cagccagccg ctgaatgagc tggcttttta 2949301 atgtaagcag cgacagggtg tggccaagag tatcgtgaag atcacgggcg attcgaacac 2949361 gttcctccct tttagagagt tcttttatct gttcgttggc ttgtgcaagc ttagcttcaa 2949421 gctcaatcct ccgaaacata gaacgaattc cgaatggaga aatgagcata atgacgagaa 2949481 acgggagaac agaaaaaagc tcccgaagcg agaccgaatt cgcgataaat tggtataggc 2949541 atggaaaaag cagtataaag attaaagcgc agaacgcacg gttaaaattc gttttctctt 2949601 tgtaataacc aacaaagttt gccggaaaaa aacctaagta tatataggtg atattgtaaa 2949661 acacactata catcaaaata accgccattt gcacgataag ccaatatgta aacgaagctt 2949721 tgcccacgct gcagaataac tggcgatatg ccgctacaaa aaggagcagc ataccatatc 2949781 cgatcccctg tttgacccct gattctttta ataaagagag gaacggcata atcgtataca 2949841 ccagaaagat ataagggaaa aacccgaatt ccttcgggaa aatagatatt gcctttttca 2949901 tgtattacac cgcttcttgt tttcttctta tatatttaga tagtagcatg aagagcatca 2949961 tataagcgat taatatcaga atatttttcc aagtcggact cccaccccgg acaagttccc 2950021 acgctccgct cccgaaatga taagacggaa gccactggcc aatgctctgc atcatgtcag 2950081 gcatgacctc aaacggcatc cacatccctc cgcctaaagc cagcagcata taaagcacat 2950141 tactgattcc ggccgctgtt tctacttttc tcatgaggcc gattagtgtg cctaatgcta 2950201 aaaaaggcaa tgcgccaaac aaaatccaca gtccgctcat catccattca aacggtgaca 2950261 aggcaatatc attgatgatt gcgccgaaca gaaatatgac ggtaattgat aaaacgtgaa 2950321 tgacactttg gccgatcatc tgagctgata aatagatatg atccggaaga ggcgtaaggc 2950381 ggataaaggc ggcccagcct tgtgaccgtt cttgtaccat tcggatgcca agcgtcatga 2950441 tagaggaacc catcacgctg aagactgtca tcgacatcag gtaatgggct tcccatgcac 2950501 gttgatcagg gacgttggta ttcactacat ttgtaaagaa ataataaaag gcaatcggca 2950561 tgatcagaga ccaaagcaca aagtacttgt tcctaagcac ccttttcatt tcagcgatgc 2950621 tttgcttttg cagcacgttc actcacatcg cctccctgtt gccgtcagcc agctggcgaa 2950681 atgcctcatc gagcgttgct tgctcaattc gaatatcccg tgcatgtatg ttttcttgaa 2950741 agatcagcgc caacactttg tctgtatttg atgtctggat gatggttctc tcatgctcgt 2950801 ggatcactct ctcgacttcc gggtgacaag acagcctttc caatgattca cttgaatgaa 2950861 gcgtaaagga aacagactgt ttttgaattc ttgagcggat ttgcattggt gagccgtctg 2950921 caacaagctg tccttcagta aaaaatagga ttcgctgtgc ggcatcatct gcttcctgta 2950981 aataatgagt tgaaaaaata atcgtttttc cttggtccga cagtccgtga atggtctgcc 2951041 agaatcggtg tcttgatgaa gtgtccatgc cgactgtcgg ttcatcaagt ataagcagct 2951101 ccgggttccc ggcaagagcc aaagcaaagc tcaaacggcg tttttgtccg ccggataatt 2951161 tttctgctct tgttttcaaa tcttctttgg tgagtgctgt taacgaaacg agttctttca 2951221 tggacaatgg attcggataa tagctccgga agagttcaag gatttcatcc accttaaggc 2951281 ccggcatgac acttacttcc tgaagcatta cacctatttt ttcacgaacc tgttgatcat 2951341 cgggaacccg gttaaatagt ttgatttctc cctcactcgg tttcagcaat cctaatatca 2951401 tcgagacgac ggtcgtcttc cctgccccat ttggcccgag aatggctgca atttctcctt 2951461 tttcaatact gaagctgatg ttgtttacag cggtttttcg ctggaaatgt tttgtcacgt 2951521 tgcttactgt tactgcttct ttcatcacat gagcacctcc tgatcgttta cattgattgt 2951581 aaaatgacgg agaagacgat gttagtatgg ggtgtcatga tgatggagtg acaaatgtca 2951641 tttttttctc accccggtgt ctaggcaatc ctcctcctgc atcttccaat tcatccatct 2951701 tttctatctc ccatgtcctc tttcttttaa actgctgtga cattcataga aagatacact 2951761 cttcaaacca tccgagtgtt atgatagaaa tattgaactt tatattactt tccggctgaa 2951821 aggagccaat catgaacgaa gcgattttgt ctagaaatca tgtgaaggtg aaaggcagcg 2951881 gcaaagcatc tatcatgttc gcacctggtt ttggatgcga tcaaagcgtg tggaatgccg 2951941 tggcacctgc ctttgaagaa gatcatcggg tgattttatt tgattacgtc ggttcgggac 2952001 attcagattt gcgcgcatat gacctgaatc gttaccagac acttgacggc tatgcccagg 2952061 atgttcttga tgtttgtgaa gctttagatc tgaaggaaac cgtgtttgtg ggtcactccg 2952121 tcggggcctt gattgggatg cttgcatcca tccgccgccc ggagcttttt tcccatctgg 2952181 tgatggtggg gccttctcct tgctatttga atgatccgcc tgagtattac ggaggatttg 2952241 aagaggagca gctccttggc ttgctggaga tgatggagaa aaattatatc ggctgggcga 2952301 ctgtatttgc ggcaaccgtt ctgaatcagc cagatcggcc tgaaattaag gaagagcttg 2952361 aaagccgttt ttgttctact gatcctgtca ttgcccgcca attcgcgaaa gcggcgtttt 2952421 tttctgatca ccgagaggat ctttcgaagg taacggttcc ctctcttatt ctccaatgtg 2952481 cagatgatat catcgcacct gcaacagtag gtaagtatat gcatcagcat ctgccttata 2952541 gcagtctgaa acaaatggag gctcgcggac attgccctca tatgagccat ccagatgaga 2952601 cgatacagct gatcggcgat tatttaaaag cacacgtgtg atataggaac gaaagggata 2952661 gaggtgaccc tcttagatgg acaaacaatt gaatgatgca ccatgcggtt tcctcgcttt 2952721 gtcagaagag gggtcgatca tagctgccaa ccgcaccctt atcaagattc tggattatga 2952781 accggagcag gttatcggcc agcacatgaa tatgatgttg accattcccg cgcagctttt 2952841 ctgccagctt tatttttttc cgcttttgaa attggagcat cacatcgaag aaatatacat 2952901 ttccctgaaa gcaagagatg gagaagaaat tcccgtcctt atcaatgcta ttgcgagaca 2952961 cgatagcggg gcttctgtct ttgattgtgt tctgattcca atgcgaaagc gaaatgaata 2953021 tgaaaatgag ctgctgatag ccagaaatga ggctcaggaa gctttgcttg ccaaacagaa 2953081 agccaatgcg gagttagaaa ttgccttgga aacgctgaaa gcaaaacaag aagaacttct 2953141 tgagatcaat aaacaaaatc aacaatttaa attaaacacc aaaagagagc ttgaactcgc 2953201 cagaaagatc cagaaaaact cgttgactga accgattgta aacgatcagg ttcagattga 2953261 ctcttattac aacgcatcga gtgaattgtc aggtgatctt tacggatatt atcaaatcga 2953321 tgaacaccgt tacggcatta ttatccttga tgtgatgggg cacggaattt catctgcatt 2953381 gattacgatg tctcttcatc ctttgttcca gcgccagatc acgcaaggtc tcagccccgt 2953441 taaagttatg aaggaattgg accggcacct tcacagcttg tttcaaaatg atgaggaagc 2953501 aagacattat tgcactgcta tttatctcga gattgatata gcacggcaaa gaattgatta 2953561 tgtcaacgca gggcatccgc cggcactttg gcaggacgat agcggaactc aacatctgct 2953621 tcacgcgacc tcgcctccga tcgggatgtt tgaagactta gagtttcagt caagcagcct 2953681 ttcatacacg gaggacggaa gattgcttct gtatacggat ggcgtgatgg atcctacggc 2953741 ttcatgttat ttatttgatt tactaaagga tcatcctgat tcgccaatcg ctgacctgaa 2953801 ggagaaaatc cttacatcac tgcagcatca aaaggaagct catcataaga gtgatgacga 2953861 atgttttata ttagttgatg taaaataaaa tgatccatga gacataacaa tgatttgtta 2953921 catctcatgg atttttttgt ttcagcgttt ctttggaata tgtcctgact ccgcatattg 2953981 aaacacctgc aaggaaggca gcgggtgtcc attaaaatca aataaagctt gattatctac 2954041 agcacttccc ccataccact tcccggcgtc ttcagggtcg tattcagcag catagctgga 2954101 cgcccaccct gacccgtatg tttcccataa cactttgttt ttctctatct gtgtcttcgg 2954161 cccgactgga atccacgccg gctcccagta gaaaacacca agtcctgctt tgcccgtatt 2954221 cgccactgcc tccattacat ctcttactgc agttgcctgg ccttgaacag aaattggata 2954281 tggcaacgtc tgcccgcttt ttggtgctgt atttccatgc ccatcgccat cctcagcggt 2954341 ataggtgtac gatgtctccg ccaccatgac ttttttgccg tacgtattgg caacagcctt 2954401 cagcacggag gtcaaatttt gtaatgtgcc atgccagaaa ggataatagg agctagcaaa 2954461 cacatcataa tccactttgt ttttgctgag tgtttctgca ataaatgaat accttccagc 2954521 cgtttcagga ttggtaaaat gcagggcgac caaaatattt gaatttgtct ccctgaccgc 2954581 tcggcttcct tcattaaata attggcacat cttcgtccaa tcagtctcac cggcaaatcc 2954641 tcctgttgtt tcatttccga cctgaaccat gccgatgtca acgccttcct tgatcatctt 2954701 ttgcaggctt tgtttcgtat actcatagag ctttgctttt tttgcttcaa agctgagatt 2954761 cgcccaggct ttgggcacct tttgtttcgc tggatcggcc cagaaatcag agtagtgaaa 2954821 gtcggccagc accttcattc cgttcgctgt cgctcttttt ccgatttcga tggctttttg 2954881 aacatcattg tttcccccgc catacccgtt gccatttgaa tcatacgggt gattccagat 2954941 gcggacgcga acatagttga ccccagcctg ttttaaagtt gtaaagatat cctggcgttt 2955001 tccgtttgta ttgtaaaagg tgacaccgct gttttccaaa gcaataacgc tggatacatc 2955061 tgcccctttg ataaaatcct tgttcatccc ctctactttt ttaacaaaaa gatcctctgc 2955121 ccgaagctct gacacgtgct tctccttctc aatggcagcg gcatatcctg ttgaactaca 2955181 tgcactccac acgatggcag ccgcaaagaa cattttcact ttgcttttca tgatttcatc 2955241 cccccaagac ttagcaagcg ttttcattct atagaaaaaa gaatccgccc atatcgagcg 2955301 gagcatcagc ctaatgtgtg tttacgacaa ttctcacttc atacttttcc atcgtcaggt 2955361 cgcctgacaa tatgtctcct gtcattatgt ccttcacact ctgatcaaac gtgaccagct 2955421 gtttttcttc cgtgaaattc atgacaaaaa tataatcatt gtcctgatcc tgcctcgctt 2955481 gtacggagac gccttttccg tgccgaaccg gaaaaactgg agagagagac aggtctgtga 2955541 tcagaccctc atagaaatca cgctgaaatt gatcctccaa acgcgcgccg ataaaatacg 2955601 ccttgccctg ctgatactca tggcttgtga ccgctggcgt gcgcgcataa aaatcttctt 2955661 gatacaccgc ttccactgaa gctgtcttta catcaatcac ggttgcataa tccttcattt 2955721 catatatttg gctgcggtag ctgacagcgt ttcgatcctt cggatacagg gtgtccgttt 2955781 caagaggctc aactccaaat atagcttgaa gatccggatg ccatccgcct gtgtatgtta 2955841 agtcatgctc attcacaacc ccgctgatat acgtcatgac taaggtgccg ccgtcagccg 2955901 taaacgcttt taaacgggaa acggtgtcct cgctgattaa atacagcatc gggacgatca 2955961 gcagtttata tggtgaaaag tcttgttctt tcgtgatgac gtcgacaggg atatcgtgtt 2956021 cccagaatgt gcggtaatgc tgctgaagcg tttgcggata acgttttgtc gccttcgcaa 2956081 acccctgagc atcctcgagc gcccaatgat tttcccagtc atataaaatc gcggtttgag 2956141 ccggcctctt cgttccgaca acttcggaca gccgttccaa tgtctcgcct accttggcca 2956201 cttcttgaaa gacgcggttc ttcgggctat tgtcatgatc cacaaccgct ccgtgtaatt 2956261 tttctgatga cccccgtgat ttgcggtatt ggaaatagag aacgctgtcc gagccgtggg 2956321 caatcatttg catggatgac agcagattca tgcccgggcg ctttgccttg ttgacgttat 2956381 gccaattgac cgcgcttggc gtacactcca ttaataagaa gggctgctgc ttcaagcttc 2956441 ggtacagatc attgataaag ccgaccttca tcgccaaatc agctgtgctt tcccagtcat 2956501 tgtgccagac aggataagcg tcccagctga tggcatcgac atgctttgca aatttgctgt 2956561 agtcgaggcc ctgatacggg atcaaatccg gtgtgtcagc cataaaattc gttgtgatag 2956621 ggatatcagg cgtcaattct ttcagcggaa tgatttcatt ttcataaaac gaaatcgttt 2956681 gatcggtgac gaaccggcgc caatctaaat tcaggccatg caagccattt tcaccgatcg 2956741 gcgaagggct ttcaatttgt gaccagtcat tgaacgtatg gctccaaaaa ggggtccacc 2956801 acgcatggtt caatgtcttg aggctgttgt catatttcga tttcagccac tcccggaaag 2956861 catgctggca taaatcacag tggcaatctc ccccgtattc gtttgaaatg tgccacatta 2956921 acagcgccgg gtgatgtccg tatcgttctg ctaataagcg gttgatgtgc cgtgtttttt 2956981 ctcggtagac tttagatgtg aggcagtggt tgtgccttcc gccgtgcagc tgtttgacgc 2957041 gggaggcatt gacgcgcaaa acttccggat aggtttgcga cagccaggcc ggacgggctc 2957101 cgctcggcgt tgctaatatg acccggccgc ctatactgtg aatccgctca aaaatatcat 2957161 ccagccattc aaattgatat acgccctcct ccggctcaag tgcgctccat gcaaaaatgc 2957221 cgacagaaaa cgtattcgta tgagaaagct tcatcagttt gatatcgtca gctaaaatat 2957281 cgggccgatc cagccactga tcggggttgt agtctccccc atggagcata aattttgctt 2957341 ttgttacgtg cgttttttca agctttgaca tcacattctc ctccttgttc tcttagccct 2957401 tcgttccgcc tgcggttaat ccggacacaa aattcttttg cagcataata aagatgacgg 2957461 caaccggtat gctgataagc agggctccgg ccgcaaatgt cgtatagctg gcccccatga 2957521 catcattcac taaattgaat agaccgacgg gcaatgtata tgattcaggc gttctcaata 2957581 tggttgagga cagcacaaaa tctccgagcg gaccggtaaa gccgttcatg gccacgactg 2957641 ccgccatcgg ttttgataat ggcagaatga tctggaagaa gattctggtg ctgctggctc 2957701 cgtcaatctt ggcgctttcg tctaaatcca tcggaatgga atccatgtac cctttcatca 2957761 aatacgtatt catcgggatc aggccgccga tataaagcaa gattagcagc cagtggctat 2957821 tgatcattcc caagatttgc gccagcacaa acaaggcaat taaagctgaa aactgaggaa 2957881 tcatctgcag caataaaaag agcgttaaag cgtatttcct ccctttaaac cgaaagcgcg 2957941 aaaacgcata ggccgtaaac gtcacacaga gcaaagaccc tgccattgta aacaggctga 2958001 tcttcataga gttgacatac cactgcacat attgaaggct ttccttgccc gcaaataatt 2958061 ccttgtaatg atcgaatgtc ggatgcttcg gaatgatgga tgtactgatt aagctgttgc 2958121 cgggattaaa gcttgcgcct gccgtccaaa ggagaggata aacaatgatg accgccataa 2958181 aggctagcaa caagtaagag aaaaggagac ggatatatct tctgactttc atatctgcca 2958241 gcatacctta tgcctcctct ttaaaagact ttgtctgtct gaactgccac aatgcgatgg 2958301 agataacaaa tacagataat aaaatggtta aagccgcagc aagtgaatat tggctggact 2958361 gcattgtcaa tttataaatc catgaaacga ggatatctgt cccgccggct gttgatccgg 2958421 ttacagccgg acctccgcca ttgaatagat agataatatt aaagttatta aagttaaacg 2958481 taaactgagt aatgataatc ggagccattg caatgaacac catcggaagc gtgatgtatc 2958541 tcagctttga aaagacagaa gcgccatcaa tcgtagctgc ttcatacaga tcgtccggga 2958601 tggattgcaa tacgcctgtt gagacgagaa agatgtacgg aaatccgagc cagccctgca 2958661 tgagaatcaa tgcaagcctc gaccaattgg catctgtcat ccacggaagc ggatctatcc 2958721 cgaagaaagc caagatgtcg tgattcatcg caccgaagct atcattaaac agtcccgcaa 2958781 aaattaaaat cgtcacaaaa ccgggaacgg cccatggcaa aatcagaatc gtccgaaaaa 2958841 aacgtttaaa ccgaaggtct ttctggttaa caatgatcgc gagaaaaatc cccaaggtga 2958901 cttgcagtgt ggatgcagca agtgtccaaa ccaccgtcca agccagtaca tcaaaaaaag 2958961 tcgacctcca aatatcaact gtgaaaatat ttgcgaacgt ttgaaaaccg acccaatcaa 2959021 ttaattttgc aggaggagaa tgatacaaat catagtttgt aaacgctaat gcaaagctga 2959081 ataagatagg aaagatcacg gcgaaaatta aaataaacaa agatgggccg ctgacgacat 2959141 aaggatagcc ctcagaaatg atatgctggt attgttcctt taaggaactt aatggcttat 2959201 tttcatcacg ctgttttccg ctttggaacg catcgcgaag atttacataa tacaccgcaa 2959261 ggccaaagca ggtcacgatg acagcaataa tcccttccgc cagcagaaaa acggaattat 2959321 cccgcggcac ttctgttccc agtgtaaaga ttccccaaaa ccccatattg agcagatctc 2959381 caaagaccgc aaaaaacgat gcgcctaaga aaagaaagac aatacctttt atccattgct 2959441 tgttataaaa ttgcccgagt cccggaatga tagaaagcaa caaagcgact tgacgatgct 2959501 gcaccgtttt cacctctctt acaatacaaa tctagctttc tctttatttt ccgctgtgct 2959561 ttgccttaat ttgtcctttg gccgtttcag ctgcttgatc caatgcttgt ttcggatctg 2959621 ccttccctgt tgcaaccgtc tgtaatgctg aatcagccgg cgtccatatt tcattcattt 2959681 ccggaatatt tggtgttggc tctgagaaac gggattgttc agtaacagcc cgtgccgcct 2959741 cgcttttcat aatagccggg tcattggcta gggatttcac agcaggaact tctttcgttt 2959801 cttcatatcg tgttttagaa tttttttcat ttgccaggaa aacggctaat tcttgcgcca 2959861 gctcttcatt ctttgaaaat gcactgacgt tgtagctttt gacgccgata aaggagctca 2959921 tgtttttccc attttccagc ttcggcagtt tcgtaatgcc ataattgatt cctgcattcg 2959981 aaaaggcttc tacattccat ggaccagaaa taattgcggc ggcttttcct tctgtgaaca 2960041 gcgattccaa cacgttaatc ccttgttctc caataatgcc agccgggaac aggccatctt 2960101 tgtaaaactt ctgaatcagc gccgcacctt tgacagctcc ttcattattg attccaatgt 2960161 ctgacgggtt atagctccca tctttggcct ttccaaaaat gtatccgcca tatccgctca 2960221 tcacactttc tgcataataa atttgatcga atagggctaa aaagccaaat ttgctgccgt 2960281 cagcagtctt tttggaatag tcgtaccact cttccagcgt tttgggcaat tccttttctg 2960341 tgatgagatc tttgttgtaa aaaagcacag tcgtttcgac cgcttttggc agtccataaa 2960401 gcttttgatc taccatttga gactgaatgg aagcgtcagt ataaagtgat tgaacgtctt 2960461 ttttgacatg taattccttg agtaatcctt ccgtgacagc ggttccgatt tggtcccctg 2960521 gcattgttaa cacgtcaggg cctgtgccgg ccggtccatc cattcgcaaa tcttcaatct 2960581 gcttggcata cggtttttca acgactttga ccttcacatc atgctctttt tcaaatgcag 2960641 ccacagcgtc tttaatgccg ttgctctttt ctttatcctc ccatacaaca agctctgacc 2960701 cttttgaact cgatttggcg ctgctgcttt cctttgggcc gcaagccgcc aaggataaac 2960761 tgacagctgc gcagagcatg aatacggaac acttttttgc cattttcatt gattgtcacc 2960821 ctttcggtag gaatgaaagc gctttaaaga taatatagca tgcctgagaa aatgtgtaaa 2960881 caaactattt acttcataga gtaaattttt ttacctaaat aaaaaatgac ttagtgtcct 2960941 aagtcatcct taattcatac tcttcctgac gattaattct gcgcccacat ataatgtttt 2961001 taccgttctt ctcttgtcct gcacttgttc aagcagtaat tgaacagcgt ttttacataa 2961061 ttcatgtata tcaatatgaa acgtcgtcag aggaggcgag acatacttcg cgaagctgat 2961121 gttgttgata ctcacaatgc ttaccctgtt tggtatggca attccttttt cgttcagggc 2961181 ttgcagacag cccactgcaa tcgggtccgc tgcaatcata aaagcagtcg gaagctgatc 2961241 gcctaatgtg tcgatcgctg ctgacatcag gcggtagccg ttttctacag agaatccgcg 2961301 atgacagaaa atatagcgct cgtccagcat ggctttttcc ctcatatagg atctgaaggt 2961361 ttgttcacgg atgtccattt catcctgatt ggtattcgga tttttgtatg tgccgccgat 2961421 aaaaccgatg ctcttatgcc ccttctcagt caggatgttt accgtcttcc ttgtcatttg 2961481 tgccaaatcg ggccttaccg agtcaaaatg atcgggatca ggagttgaat cgatgaacac 2961541 gccgttttca gtgagatttc tgaggaaagc cagctcttca tctgaaaatg tgccgacggc 2961601 aataaaccct tccgtatgtt caggaatgct ctcgattcca tccgctattt tataagtggt 2961661 catatcgaca ttgaatgctt tcgccagttt ctctacttct aatctcatcg ttttaaaata 2961721 gacatcttct aattcttctt tatctgtcag ccaatataaa aacgcaatat gtttcaccag 2961781 cggccttact gtttttttgc ggtaattgag cttttccgcc gcttcataga ttttctcccg 2961841 tgtctcatca ggaacagaaa ggctttcatc gttatttaaa acgcgggaaa cggttgagat 2961901 tgaaaatccc gcttcctgcg cgatatcttt aattgtcgcc attgtatctg cctccattat 2961961 tcagctcgca ttgttttagt aaaatatttt actttctttt tcacaaatgt caagtgcaca 2962021 aagccctctg gctgccatgt aaaaagactg aaccatttgc ggctcagtct cagttgttcg 2962081 tatcattcgg aaccggcgga attgcccggg aaatgagttg gttattgcac attttcctcg 2962141 aaatatcccg aaagcacatc ttccacattc gtcaaatgcg ccagcatggc ggcttccgcc 2962201 tgtgcaccgt tcccggcagc cacagcattg taaatccgtt cgtgctcctc atacagccgc 2962261 tgaacggagg tcttcttgga aaacagccag attttcctcg tttccctcat tgtttccagc 2962321 agcaatgatg acacgtgatt catcaagtgt ttaagaagtt cattttgaga agcgtccgca 2962381 agcgcaagat gaaatgcaaa gtctgctttc tctcccagct ccccgtccgc ttcaatgctg 2962441 cccatttcct ttagtgcatc ctgaattctt tcgagatctg cttctgtcct tttttcagcc 2962501 gctagtgaag ccacgccgat ttcaagcagt tttctgacct cgagcagctg cttgacgtcc 2962561 tcttttttca tcagaagggc ggctgagagc ggctgagaaa tttgattgag ctcaaattcc 2962621 ttcagatacg tgccttctcc ctgtttcatt tcgacaagcc ccatcgcttt tagcgcagaa 2962681 agtgcttcgc gaaccgctga acggctgact tgaaagctct cagcaagcgc ctgaacagag 2962741 tccagtttat cccccggctt caattcgcca tttttgatca tatctaatag ggcatccgct 2962801 acttcttcat atattttttt gttttaatct gtttatattt caatgcaatt caccccgtaa 2962861 cttgtaggtc tggctgttta cgatctatta tactctgttt tgtgggccgc caaaagattt 2962921 tgactatttt gtcaaaaagt cttgtacttt gatttttttc aaaatataat gctaggtaac 2962981 tggtcttatt acccagtcat cagatgatca tatcatctat agaaaccgct tacatatggc 2963041 gccagtttat gtttcaagga ggggtttggg atgcaatgga cacaggcata tacgcctata 2963101 gggggaaatt tgctattatc agcgcttgcc gcacttgtac cgattatttt ctttttttgg 2963161 gcactcgcga ttaaacggat gaaggggtat acagcaggct tggccacatt ggggatcgcc 2963221 cttatcattg ctgtattggt ttatcgtatg ccggcggaaa aagcgctgat gtccgcgaca 2963281 caaggagccg tatacggatt gttgccgatc ggctggatca ttgtgacgtc tgtttttttg 2963341 tataaaatca ctgtgaaaac gggacagttt gatatcattc gcagctctgt tctctcgatt 2963401 actgatgacc gacggcttca agctctcttg atcgcttttt cattcggggc ttttttagaa 2963461 ggggcagcag gcttcggagc gccggtcgcc atttctgccg cgctgctggt cggtctcggc 2963521 tttaatcctc tttatgctgc ggggatctgt ttgatcgcca atacggcgcc ggttgccttt 2963581 ggggcaattg ggattccaat tacagccgta gaagggccga cagggattcc ggcgatggag 2963641 atttcgcaaa tggttgggcg gcagctgccg tttttatccg tatttattcc tctttattta 2963701 atcatcatca tgagcgggtt caggaaagcc ttggagatct ggccggcgat tctcgtatcc 2963761 ggtgtttcct ttgctgttgt tcaatatctc agttccaatt ttttagggcc tgagctgccc 2963821 gatgttttgt cagctcttgt ttcaatggct gcgcttgctg tgtttttgaa atggtggaag 2963881 ccgaaaacaa cattccggtt tgccggtgaa caagagtcgg ccgcctcaat tgaaacggcg 2963941 cgcacaaatc cggcggcgcc tgcatacaga ggcggacaga tttttaaggc ttggtcgcca 2964001 tttctgctgc tgacggcgat gatttccgta tggggcattc catctgtcaa atccgcgctg 2964061 accgggcatt atgaaggctc tgcggtgttc ttgaagtggc tgaatgctgt tggagaaaaa 2964121 ctgacttttt cccccggtgt gccttttttg aacaatcaga ttgtcaatgc tgacggtacg 2964181 ccgattgaag cggtttacaa gttggaggtg cttggttcgg ccggcaccgc gatattgatt 2964241 gccgcagtgc tgtcaaaatt catcacggcg atttcgtgga aagactgggg aaccgttttt 2964301 aaagaaacag tccaggaatt gaagcttccg attttgacca ttgcttctgt cgttggtttt 2964361 gcctatgtca ccaactcctc gggaatgagc acgacactcg ggatgacact cgcgctgaca 2964421 ggttcgatgt ttaccttctt ttcgcccgtt ctcggctggc tcggcgtctt cattaccggc 2964481 tcggatactt ctgccaacct gctgttcggc aacctgcaga aagtcaccgc attatcagtc 2964541 ggcatggacc ccgttctgtc tgtggccgcc aactcttcag gcggtgtcac aggaaaaatg 2964601 atttcaccgc agtcgatagc ggtggcgtgc gccgcggtag gactcgccgg aaaggagtca 2964661 gatcttttcc gctttaccat taaacacagt ctgtttttgc tgctgctcgt ctgtatcatc 2964721 acctttttgc agcatcacgt attcagctgg atgattcctt aaaaaaatcc tcccgtctag 2964781 ggaggatttt atttatatcg ctttctcgct gccgatgacg gaatattcat ttgatcgcga 2964841 tattttgcca cggtgcgtct cgagatttgg atgccgtgtt gttcatacag caaatcgaca 2964901 agcttttggt ctgaaagcgg ttttgttttg tcctcttgat tgatcaggtt ttccagatgc 2964961 gttttgactg cataattcga cgcatctcca tcacctgaag cctcggcttt tgctgagaaa 2965021 aagagtttca tctcaaacag cccgtaaggc gtttgtattg ttttcccttt aatggcccgg 2965081 ctcacagttg attcatgaag gcttagacag tctgccacct ctctgagagt cagcggcttc 2965141 attgcgcttc gccctttcag aaagaaatcc ttttggcgtg tgatcagttc attgataatt 2965201 ctcgtgattg tctgttttcg ctgccgcagc gcgcggctca gccagcgcca ctcctgatat 2965261 ttcgcagata aataggagac agtatcctga caggagccgg atgataaaag cgttctgtac 2965321 tgcggatgca gatcgatctc gggaaacgag cgggtattca gttccgctgc gatgtgccca 2965381 ttttttacgg tgataaaaat gtcaggctca atatacacat cttgctctgg ccgggcaaac 2965441 agaaggccag gtctaggatg aagagccgcg atatcatctg agatatcttg aatggtatga 2965501 agcggaattc ccgtctctac tgaaagcgtt ttccattttt tttgcgcaaa agcatcaaaa 2965561 tgagctgaaa ccagcatttc cgcttgttca tttctgttcg gcagccgctg taattgaaga 2965621 aggatgcatt cctgcaaaga tctcgcgccg attccagccg gttctaacga ctggagtttt 2965681 gccaaaacag cctccgcttc cttggccgat acagataatc gccgtgctgc ctcctctata 2965741 tcttcttcca agtacccgtt tgaatcaagc gaatgaatca gataattaaa aatctttttt 2965801 tcagtgtttg tcagattcat atcgagtgac tgctgtttta acgcatcctg caatgttttt 2965861 tgcggattac ttaattgaag gcccgcttcc tgtgcattca tcctgttttt gtttgtttta 2965921 tggtaagata gtggcggtgt gtctgtttcc tttcgttcaa taagagggtt ttccagtgag 2965981 agctcatcaa tgtactcggc gagttctgcc gaatgatagc caagcagcgt gatggcctgc 2966041 ctgagctcct gtgtcagttg aggctttaat acttgtactt gctgaagttt catatccatc 2966101 ttgctcactc ccctttcttc attgtacatg attgagatca caccgtatac atttatgaaa 2966161 aaggagctgc caaagaaatg tctgaacttt tttccgtccc ttattttatt gagaatttaa 2966221 aacagcatat tgaaatgaat cagtctgagg ataaaatcca cgcgatgaac agctactacc 2966281 gttccgtcgt ctcaacacta gtgcaggacc agctgacgaa aaacgcagtt gtcctgaaac 2966341 ggattcagca tttagatgaa gcatacaaca aagtcaaacg tggagaatca aaataaacct 2966401 tccgaattcg ggaagatgat gatcggttaa agggctaacg ttcgcatcta taggggaaat 2966461 ctgtttataa tgggggaaaa agggagagaa cacaatgact catcaaatag taacgactca 2966521 atacggcaaa gtaaaaggca caacggaaaa cggcgtacat aagtggaaag gcatccccta 2966581 tgccaagccg cctgtcggac aatggcgttt taaagcacct gagccgcctg aagtgtggga 2966641 agatgtgctt gatgccacag cgtacggctc tatttgcccg cagccgtctg atttgctgtc 2966701 actttcgtat actgagctgc cccgccagtc cgaggattgc ttgtatgtca atgtatttgc 2966761 gcctgacacc ccaagtaaaa atcttcctgt catggtgtgg attcacggag gcgcttttta 2966821 tctaggagcg ggcagtgagc cattgtatga cggatcaaaa cttgcggcac agggagaagt 2966881 cattgtcgtt acattgaact atcggctggg gccgtttggc tttttgcact tgtcttcatt 2966941 taatgaggcg tattctgata accttgggct tttagaccaa gccgccgcgc tgaaatgggt 2967001 gcgagagaat atttcagcgt ttggcggtga tcccgataac gtaacagtat ttggagaatc 2967061 cgccggcggg atgagcattg ccgcgctgct tgctatgcct gcggcaaaag gcctgttcca 2967121 gaaagcaatc atggaaagcg gcgcttctcg aacgatgacg aaagaacaag cggcgagcac 2967181 ctcggcagcc tttttacagg tccttgggat taacgagggc caactggata aattgcatac 2967241 ggtttctgcg gaagatttgc taaaagcggc tgatcagctt cggattgcag aaaaagaaaa 2967301 tatctttcag ctgttcttcc agcccgccct tgatccgaaa acgctgcctg aagaaccaga 2967361 aaaagcgatc gcagaagggg ctgcttccgg tattccgcta ttaattggaa caacccgtga 2967421 tgaaggatat ttatttttca ccccggattc agacgttcat tctcaggaaa cgcttgatgc 2967481 agcgctcgag tatttactag ggaagccgct ggcagagaaa gttgccgatt tgtatccgcg 2967541 ttctctggaa agccaaattc atatgatgac tgatttatta ttttggcgcc ctgccgtcgc 2967601 ctatgcatcc gcacagtctc attacgcccc tgtctggatg tacaggttcg attggcaccc 2967661 gaagaagccg ccgtacaata aagcgtttca cgcattagag cttccttttg tctttggaaa 2967721 tctggacgga ttggaacgaa tggcaaaagc ggagattacg gatgaggtga aacagctttc 2967781 tcacacgata caatcagcgt ggatcacgtt cgccaaaaca ggaaacccaa gcaccgaagc 2967841 tgtgaattgg cctgcgtatc atgaagaaac gagagagacg ctgattttag actcagagat 2967901 tacgatcgaa aacgatcccg aatctgaaaa aaggcagaag ctattccctt caaaaggaga 2967961 ataaatatgg ggaaaacagg atacattggt gctgccattg ttgtggcagc ttgtatcatt 2968021 attttgtcgg ccgtggtatg tttacgggac acagtctatt accagcctat gcgctggact 2968081 ggcatcatac tgtttttcgc gggaattgtg atggttcccg catactcagc aaaaagaaaa 2968141 cccggaaaag agaagtaatt ctcttttccg ggtttttatg tttattataa tcttcccgcg 2968201 cgaatatcgt ctgtcattcc ctcataagga gccttcgaaa tcacttcttc gttgtcgact 2968261 ccttcatttt tcagaaatgt aatttccgca aattcaggta caacgtattt tggatacgtt 2968321 tcatattttt cgcgggattc tttcatcaaa tcaatgtggt cattttggta gcaaaccgta 2968381 atttcaggat gttcatgcac ccatttcggg aagaaaataa tgccatgcat gcgtttttca 2968441 tttggcataa agtttaatga aacatccgtg ccagtcggct ctgtccaaga cactttatat 2968501 acgccttctg tcagtttgac aatattcact tcctgatctc gaacccagcg tccggcaacc 2968561 attccgctat gaattctata atcaattgta tggtcgtttt taatataaat ctcgtattcc 2968621 catccgtttt catacgtata aatcatgtgg cttccgataa agttttccat cttacacact 2968681 ctccttagtc ttttactgta cttcataaat gtctagtaga acgtaatcag gggttctttc 2968741 tgcggaaccg ataaacaagc ggtcatggag ccattgatag acttcactgc ctgtttcaaa 2968801 cgtcggtacc gtacgaaaat aaacatgctc cggttcaata atttccccgg ctgccgcttg 2968861 ttttcgaaac ggcttgctga cttgccgtat tccattgttt tcaatgtaaa tcagttcatg 2968921 atctgctgtt tcaatcacat acctggcaga taaatctgtt ctgccgttag cgcgaatcat 2968981 ttgtgaatcg gcaccgcccg gcaaaatacg tccctttact tccccggtta ttgttcccga 2969041 acgaatcgga atgaatcatc tcagtcccag gcttgtctca ccaatcgtga taggcggatc 2969101 aaccttgatt tctaaagagg cgaatggttt taaaaccggc ttcttcacga gaaccacctc 2969161 accttcagaa aaaatcatgt aactatttac atgttcactt taacaccatt gcagttaact 2969221 gtcaaacaat aggaacataa aaaaacaagg actgtttgaa gacagtcctt gtctgaagct 2969281 agctttgata agcaagatat gtgctgacag tgcttttggc aagacaggca gaggaatcta 2969341 taatcggaat ctcactttga atatgatcta acaccgcatt taaatccgtg caggctgaaa 2969401 tgatgatgtc tgcatgctga ctgatttctt catatagcgt ctgccacaat gcttgtgtat 2969461 gctgcatatg atttggctgt ttgattgcgg cgataagctg gttcacagcc tgctgccaat 2969521 ggtccttgtg aataacttct tgtccatttc ccttcagaac tttttggtag atggcggatt 2969581 ggatggttgg ctctgttcct aaaaccaccg ctttttttgc gggatgcgga atctctttta 2969641 tcgtttcctc aacaatatgc aacataggaa ctgacaatgc ctgctgaatc tcttcatagt 2969701 agacatgcgc cgtattacaa ggcagcgcaa tgaaatccac gcctgttttc tcgagcttta 2969761 ccgctccgtc gataatcgct tttttcatct cgtcatggtc aattggacga tctgcataga 2969821 agggcgtcgg gcatgaatag atcatcatgt gcggatagtc aatatcgttt gaagccccat 2969881 acagcttctg acagtaatca atcaccttat caataaacgg cgaggtcgat ttcggcccca 2969941 ttccggctaa tattccgatc atcaaattca ttcctttcta cttcgtacgg accgcttctt 2970001 cctctgagcc atcctcatag aggataaagc ttttcgcagc atcctcacct aatgtaaact 2970061 cgacttcaac agacaatgct cgcagaaaga aacgggtttc cgaggaagga aataactcca 2970121 gtctcagctg tccggcgatc tccaaataaa gccgttcatt ctcggttgtc acctgtgcag 2970181 ccgtcccatc ctgcaacagg tagctgccaa catagcggct gtatatcgcc gtatcaattg 2970241 cttttttctt tttatcagca ggacgttccg ggacatcata tggctggcca aatagaatat 2970301 gttccgccgc cttcagaatc gcttgttcat attcagtatc ctcttcctta ttactcaaat 2970361 agatcagcgt tttacgatga tcgatatatc ggatcatcat cgtcgaatag ccgggccatc 2970421 ctccgctgtg gctgacaatc cgcccttttt caggactgtt ttgcagcacc cagccaaagc 2970481 cataatcaat tgtttctcca ttgttgaggc gcactggaga aaacgcagat tccttagaag 2970541 ccttgctgat gaaatcgtcc tgatataaag cctgatcaaa tcgaaacaaa tcgcttgtga 2970601 cagagttaac cgtcccatct ccctgtatgc catcgagata cacaacatag ttcgtttcct 2970661 ccagctcatc agggaggacg tatgtttcgg aatgtacatc atacacatat ccatatgcat 2970721 aatgatcaat tcgctcaggc gaaagcctcc tgttatacac tcttgtttca ttcatgcctg 2970781 ccggtaaaaa aatacttgtt tttataaaat ccgcatagct catgccagat gctttttcaa 2970841 tgataaccgc cagcagcaca taccccgtat tgctgtacat ccagccttca ttcggttcaa 2970901 aataaccaga tagcccctca ttcatcagca tatcgacaat atcctgattc accgcaatct 2970961 tgtgtgaatc ccaattggca aaaaaccatc ccatataatc aggaagccct gacgtatggt 2971021 tcaataaatg ccgaatcgtt acgccctgat acggaaaacc gggcagccag cgatccactt 2971081 tatcctcata gccaagaatc cccttctcct ccagcaagat gattcccaat gctgtaaaag 2971141 gctttgacaa agacgctaac tcaaacaaag agttggtttt caacgggcgt ttttccgtca 2971201 tttccgcata gccaaaagag tggtgatata aaatatcgcc accctccgca gccagaaccg 2971261 tcccgttaaa ctgatgtttt tcgcctaatg tctcaaataa cgtctgaaga tgctttcttt 2971321 tattctgctt cattcctcca cctcccatat ctctgtacgt tactaaccta ctaacgtttc 2971381 aaatattttg aaaaatcctt cagttagaga tcctttttaa cccatcacat atacctgccg 2971441 ttcactatta tttagtgaaa tgagatatta tgatattttc tgaattgtga ttaaaaaggc 2971501 aactttatgc ccatgcaaca gaaactataa aaaatacaga gaatgaaaag aaacagatag 2971561 attttttagt tctttaggcc cgtagtctgc aaatcctttt atgattttct atcaaacaaa 2971621 agaggaaaat agaccagttg caatccaaac gagagtctaa tagaatgagg tcgaaaagta 2971681 aatcgcgcgg gtttgttact gataaagcag gcaagaccta aaatgtgtaa agggcaaagt 2971741 gtatactttg gcgtcacccc ttacatattt taggtctttt tttattgtgc gtaactaact 2971801 tgccatcttc aaacaggagg gctggaagaa gcagaccgct aacacagtac ataaaaaagg 2971861 agacatgaac gatgaacatc aaaaagtttg caaaacaagc aacagtatta acctttacta 2971921 ccgcactgct ggcaggaggc gcaactcaag cgtttgcgaa agaaacgaac caaaagccat 2971981 ataaggaaac atacggcatt tcccatatta cacgccatga tatgctgcaa atccctgaac 2972041 agcaaaaaaa tgaaaaatat caagttcctg aattcgattc gtccacaatt aaaaatatct 2972101 cttctgcaaa aggcctggac gtttgggaca gctggccatt acaaaacgct gacggcactg 2972161 tcgcaaacta tcacggctac cacatcgtct ttgcattagc cggagatcct aaaaatgcgg 2972221 atgacacatc gatttacatg ttctatcaaa aagtcggcga aacttctatt gacagctgga 2972281 aaaacgctgg ccgcgtcttt aaagacagcg acaaattcga tgcaaatgat tctatcctaa 2972341 aagaccaaac acaagaatgg tcaggttcag ccacatttac atctgacgga aaaatccgtt 2972401 tattctacac tgatttctcc ggtaaacatt acggcaaaca aacactgaca actgcacaag 2972461 ttaacgtatc agcatcagac agctctttga acatcaacgg tgtagaggat tataaatcaa 2972521 tctttgacgg tgacggaaaa acgtatcaaa atgtacagca gttcatcgat gaaggcaact 2972581 acagctcagg cgacaaccat acgctgagag atcctcacta cgtagaagat aaaggccaca 2972641 aatacttagt atttgaagca aacactggaa ctgaagatgg ctaccaaggc gaagaatctt 2972701 tatttaacaa agcatactat ggcaaaagca catcattctt ccgtcaagaa agtcaaaaac 2972761 ttctgcaaag cgataaaaaa cgcacggctg agttagcaaa cggcgctctc ggtatgattg 2972821 agctaaacga tgattacaca ctgaaaaaag tgatgaaacc gctgattgca tctaacacag 2972881 taacagatga aattgaacgc gcgaacgtct ttaaaatgaa cggcaaatgg tacctgttca 2972941 ctgactcccg cggatcaaaa atgacgattg acggcattac gtctaacgat atttacatgc 2973001 ttggttatgt ttctaattct ttaactggcc catacaagcc gctgaacaaa actggccttg 2973061 tgttaaaaat ggatcttgat cctaacgatg taacctttac ttactcacac ttcgctgtac 2973121 ctcaagcgaa aggaaacaat gtcgtgatta caagctatat gacaaacaga ggattctacg 2973181 cagacaaaca atcaacgttt gcgccaagct tcctgctgaa catcaaaggc aagaaaacat 2973241 ctgttgtcaa agacagcatc cttgaacaag gacaattaac agttaacaaa taaaaacgca 2973301 aaagaaaatg ccgatatcct attggcattt tcttttattt cttatcaaca taaaggtgaa 2973361 tcccatatga actatataaa agcaggcaaa tggctaaccg tattcctaac ctttttagga 2973421 atattgctgt ttatcgactt atttccaaaa gaagaacatg accaaaaaac aaaatcaaaa 2973481 cagaagccgg actaccgggc ggcatatcat tttacgacgc cggataaatg gaaaaatgac 2973541 cctcaaaaac cgatctattt tgatggcaag tatcattatt tctatctata taaccgggat 2973601 tacccaaaag gcaacggcac agaatggcgc catgccgtct cagaggattt ggtgcactgg 2973661 accgatgaag gcgtggcgat tccgaaatat acaaacccgg acggtgatat ttggaccggt 2973721 tccgtcgtgg tggataaaga gaacacagcc ggcttcggga aaaatgcgct tgtcgcgatt 2973781 gtgacacagc cctcagccaa agacaaaaaa caggaacaat atttgtggta cagcacagat 2973841 aagggaaaat cattcaaatt ctacagtggc aaccccgtta tgcctaatcc gggcacagac 2973901 gatttcagag atccgaaagt catatgggat gaccaagata acaaatgggt catggtcatg 2973961 gctgaaggat caaaaatcgg cttttatgaa tccgataatc ttaaggactg gcattacaca 2974021 agcggattct tcccagaaca ggcgggaatg gtggaatgtc ccgacctcta catgatgcgg 2974081 gcaagcgacg gaacgaataa gtgggttctc ggtgccagcg cgaatggcaa accgtggggc 2974141 aaaccaaata cgtacgccta ctggaccgga agcttcgacg gaaaagaatt caaagcggat 2974201 cagactgaag cccaatggct tgactatggc ttcgactggt atggcggtgt gacgttcgaa 2974261 gacagcaaaa gcacagatcc attagaaaag cggtatgcgc ttgcctggat gaacaattgg 2974321 gattatgcca acaacacccc gacaatgaag aacggcttta acggcacaga ttctgtcata 2974381 cgcgaactcc ggctgaagga gcaggatgga acatacagcc tcgtctcaca gccgattgaa 2974441 gctttggagc agctgactgt ttcaactgac gaaatagagg atcaggatgt gaacggatca 2974501 aaaacattgt cgataacagg tgatacgtac cagcttgata cggatctttc ttggtcagag 2974561 ctaaagaatg caggcgtcag gctcagagaa tcagaagacc aaaaacgcca tattgatgtc 2974621 ggcattttcg ctgaaggcgg ctatgcttat gtcaatagag cagccacaaa tcagcctgac 2974681 aaaagcaata cctatgtcga aagcaaagct ccttatgatg taaacaaacg taaggtgcat 2974741 ttgaaaatac ttgtcgataa aacaacgata gaagtatttg ttggcgacgg gaaaaccgtt 2974801 ttttcaaatg aagtcttccc aaagcctgaa gataaaggaa ttacccttta ttctgacggc 2974861 ggcacagcct ccttcaaaaa tataacagtg aaacactttg attcgattca tgaataaaaa 2974921 caggggcggc gcaggctgcc cctgtttttt tattaggagc ggtattctct gttacatatt 2974981 gggcattgta aggaatataa ggctggtttc aaaggaggaa gcgaatgtct aaacaaggaa 2975041 attttcaaaa atcaatgtcg ctgtttgatc tgattttgat tgggatggga gccatctttg 2975101 gatcagcgtg gctgttcgct gtcagtaatg tcgcttcaaa agcagggccc tccggcgctt 2975161 tttcctggat cctcggagga gccattattt tgttaatcgg gcttgtatat gcggagctcg 2975221 gagccgctct gccccgtacc ggaggcatca ttcgataccc cgtttattca catggccacc 2975281 ttgtcggcta cttaatttcg tttgtcacga ttgtcgctta tacaagcttg atttcaattg 2975341 aagtgacagc tgtgcgccag tatgtggcct attggtttcc cggcctgacc attaaagggt 2975401 ctgattcgcc taccatttcc ggctggatct tgcagtttgc cctattatgc ttgtttttcc 2975461 tgctgaatta ttggagcgtc aaaaccttcg ctaaggcgaa tttcatcata tcgattttta 2975521 aatatattgt gccgattacc atcattattg tgctgatctt tcattttcag ccggagaatt 2975581 tatccgttca aggatttgca ccgtttggat ttacaggtat tcaggctgcc atctcgacag 2975641 gcggcgtcat gtttgcgtat ctcggcctgc atccgattgt atctgtagca ggtgaagtcc 2975701 aaaatccaaa acgcaatatc ccgatcgctt taatcatttg catcatcgtt tcaaccatca 2975761 tttatactgt tttgcaggtc acctttattg gtgcaatccc gacagaaaca ctgaaacatg 2975821 gctggccggc aattggccgg gagttctcat tgccgtttaa ggatattgcg gtcatgctcg 2975881 ggttaggctg gcttgcaacg cttgtcattt tagacgccat tctgtctccc ggaggaaacg 2975941 ggaatatctt tatgaatacg acatcccgcc ttgtttacgc ctgggcgcgt aacggcacat 2976001 tatttggcat attctcaaag gtcaataaag atacggggac accccgcgct tcgctttggc 2976061 tttcgtttgc cctgtccatt ttctggacac ttccctttcc ttcgtggaac gcgctcgtca 2976121 atgtctgttc agtcgcgctc attctttcat atgcgattgc acccatttct tcagctgcgc 2976181 tgagggtcaa cgcgaaggac ttaaacaggc cgttttattt aaagggaatg agcattatcg 2976241 ggccgctttc ctttatattt acagcgttta tcgtgtactg gtcaggatgg aaaacagtct 2976301 cctggctgct cggttcacaa ctcgtgatgt ttttgatcta tctctgtttc agcaaatata 2976361 cgcctaaaga agatgtcagc cttgctcagc agctgaaatc agcctggtgg cttatcgggt 2976421 tttatattat gatgctgatc ttttcctaca tcggttcttt cggacatggt ttagggatta 2976481 tcagcaatcc cgtcgacctc attttagtcg cgatcggctc acttgcgatt tattactggg 2976541 caaagtatac cgggctccca aaagccgcca ttgattatga taaataaaga agcaagaggt 2976601 tttcttgctt ctttattctt tacaaacaaa catacacgcg ataaaatgaa tgagagtcag 2976661 tcattactgg aggtgttcct catgccaaaa caaacatcgg gtaaatacga aaaaatattg 2976721 caggcggcca tagaagtcat ttctgaaaaa ggcctcgaca aagcttctat ttctgatatt 2976781 gtcaaaaagg ccggcactgc ccaaggaaca ttctatttgt atttttcatc taaaaatgcc 2976841 ctcataccgg ccattgcaga aaatctcctc acccatacac ttgatcaaat caaaggtagg 2976901 ctccatgggg acgaggattt ttggaccgtt ttagatatat taattgatga gacatttctc 2976961 attacagaac gccataagga tattattgtc ctctgttatt ccgggcttgc gatcgaccac 2977021 tccatggaaa aatgggagac gatctatcag ccttattatt cctggcttga aaaaatcatc 2977081 aacaaggcca ttgcaaacca tgaggtaacg gaaggaatca attcaaaatg gacggccaga 2977141 acgattatca acttggtcga gaatactgcg gaacgattct atatcggatt tgaacaagat 2977201 gaaaatgttg aagtgtataa aaaggaaatt ttcactttct taaaacggag cttaggtact 2977261 gcttaaaaaa tgactgggta acaccgctca ttttttaatg ccctaaaaat gactgacgtt 2977321 cattcataaa atagagaggt gtttcatttg aattgggttc ttgtttttat tgcagggctt 2977381 ttagaggttg tttgggcctc ttccctcaaa catgccgatt cgcttttgga ttggatcatc 2977441 atttttatct taatcgcggt cagctttatc ctgttgatcc gctcttatca aaaaatcccg 2977501 atggccgcgg cgtacactgt gtttgtggga atcggaaccg tcggaacata tctgactgga 2977561 attgttctgg gcgaatcctt ctcagcagcc caaatgttct ttttagcttt attgctggct 2977621 ggcattttag gaatgaaatt atttacgaaa gaaagcaaat ctcagccggg aggtgaaaaa 2977681 taatggcatg gtttttatta gtgattgccg gcatagaaga aattatagct gccattgcca 2977741 tgaaatatat agacggaaca agaaaaaaat ggccgatcat tgtgatgact gttggattcg 2977801 gcttatcctt ttactgcctg tcccaagcga tgatcgtcct gcctgccgga gtcgcatatg 2977861 ccgtctggac tggcattgga agcattggtg tttcggcggt cgggctcatc tggtttaagg 2977921 agcggtttca gctttcacag gtgatttcac tttgccttat cctagccggc gtcatcggcc 2977981 tgcgtcttac gtcatcttca taaaatcaag gcatatacag ctgtatatgc ctttgccatt 2978041 aagcttcgtg atgtttttga agatgaagcg gcggcgggat gagccagcct ttgtttttta 2978101 gcagccttaa gtattttgcg ccggttgccg ctttcgacat atgaaattgc ccaaacatca 2978161 tggcaatatc ctcacgaatc gattgcccca tcattttgct gcatgtcaca agacctgcag 2978221 cattttctgc tgccgcggaa gccgccacat ccggatcgag aaaccgtgca ccaggcggaa 2978281 tatcgttaag atctgctgtc ggcggttcag gagaagccgg cggcagcgcc accccgtttt 2978341 ctttcaggat cgtgctgacc tgtttgattt catcttggca tttctcaata gactcacgaa 2978401 gcagcttctt caggtcgtca tcaccgacat gattcaatag catttggtaa ttgccgacca 2978461 ttttattgcc cgccatcaca taactccaca agccgaatac ctcaccgtaa tgcatcggtt 2978521 catcctgcgg atttccgctt aaaataccca tgctcattct cctcccatat tcaatattgc 2978581 acatttcata acgtgcccaa gcggaggaac atttatgttt cagcggaaaa gatttatgaa 2978641 atgaaacaaa acaaaaaaga caagagtggc aagttgccaa accattgtct ttcctgttgt 2978701 ttgattggac gcactgaagg gattcgcacc ccgacagaca agataccgga aaccattcaa 2978761 gtgcttttta gtatgagtca ttgattctgt ctttaataaa ctttaacgag atggcgggat 2978821 gctttgcgga aaacgaaata cattttcggg gtcatatttc gcctttattt ctcgaagccg 2978881 cgcaaagttt gcgccataat attcttttcc gaagttttca atgttttgat ctggaacatt 2978941 aacatatgaa cctgctacat atggttgcat cagctgacgc actctttcaa ctgatgcaag 2979001 atttgaatct tcttgtgatt tatttttcca actagccgtc cattccgtat aaaataatgg 2979061 atggcgccaa aaaaaggcag tttcgtcttt agggactctg cttatagcac caccccaatt 2979121 gataaaaaag aaattggctt ctgttccagt agcatcttcc aaaaattttc tcatgattga 2979181 aatgggttcg tcagaccaaa aatcatgacc ccatgccgag gagaatttaa cactctgatc 2979241 atttctgcca gggatgggtt cgtcagggtc taagaaatct atagcatctg gatagtataa 2979301 tgttttgata tctgcttctg ttggagttcc cgcatgtaat aaaggtttta ataatcgaat 2979361 caattcagtt ttcgaaccga ggaaaattcc ttctgcatga cacaaaccat ttattttgct 2979421 gtaaatttca aggtagcatc ctaatcgttc atctacaaac ggagcccatt tctgccaagc 2979481 tttaaatacc gtttctaatt gttcccacgg ccagataata ttgaagacgg ttgcagtttt 2979541 aggggcacga tgaactttga atgtatattg ggtattatat ccaaagttac ctcctcctcc 2979601 gcctctagaa gcccatagca aatcctcatt gtgagattga tctgcgtgaa taatccttcc 2979661 ttttgcatct accgttttca gcgcgagaag gttatcactt ataaggccaa tcgatcgtga 2979721 gagtacacca aatccgccgc ccatcgtaat tcccccgatt ccaactgttg ggctatctcc 2979781 aaacggagcc ataaaaccgt ctcgagctaa tccctttaca agcgggccaa cgggaatacc 2979841 agtttgaacg gttgcaatag cgttttcttc atctaagaaa actttattca tgtcactcac 2979901 atcaataaca attcctccac ttactactga aaggttctta tctaaagcat ggcgaccgct 2979961 tctgacacgt aagggcactt tattctcacg agcccattta atggcattac ttacatcgta 2980021 tgaattttgc gcaaaaacaa agacaagagg atagacatcc acataagggt tccaattctt 2980081 aatagcctct gtatagccgg ggtctccttt gaagattaca cgccctgtca actgtgttga 2980141 tcccatatat tatttcactc ccaaagaaat tcgattcaga tactaaaata tgcaggagct 2980201 ggataatcgc atagacaaat gatctacgaa ctataaatat aatacgctaa ggcctttttc 2980261 gtcggtgagg tctgctgaga aacatttttc aaacaatttt gagcaaactt cctgtccaat 2980321 cctccaacaa gcgttttttc ttatcgtttt taggagcagt gtccagtttt tttcggagtg 2980381 aatattcgtt taggccaaaa gaaaagagag atgaagaagt gtttagtacc agaggtatac 2980441 atccatacaa cagactctag atcatcatat actgaatgta tgtagaaagg agacatcagc 2980501 tttggcaaaa tatcggatta tgacctttga cggcggcggt accttaggtg ctttaagttt 2980561 acaactatta aacagattgg ctaggcaaaa cccgaagtta attagtcgaa cccatgtatt 2980621 ttcgggaaat tcaatcggtt catttactgc ccttgcatta gcaagcggaa gatctccgag 2980681 ggaaacactt cagtattttg aggatgaaat cctacccgca ttcagcattt cccggccagg 2980741 cggacctgtt ttcaaccaac aattacccta ttccggtttt attaaagcgg taagaaattt 2980801 tttcccagca gatcttcaac ttatagattt aagaaaacga attgttgtcc catcattcaa 2980861 attatactct caaaaactgg accgttggac tcctgtctta tttcacaatt ttcccggctc 2980921 tccctattta aatgaaaaag tgagtgatgt catactgcgg agcagcggtg ctcccgcgac 2980981 gcaacgcgcc tatcaaaact atgtggacgg atatgtagta gcaacgaatc ccagtacagc 2981041 cagtatcgcg tttgcagttg gtaaagccaa cgtgccattg gatcaaattg cggtattgtc 2981101 catcggaaca ggtgaagccc cgactcggtt aagaagagat acgaggggat ggggaatggt 2981161 aagtgcagat aacatacgtc ccgaaaatct gaagaacctt cctccaaatt ggggagtcct 2981221 tttggacagg tcgcctaatg aacctttact gccatttctt cagatgattg ctggcggtaa 2981281 tgggtactat gaatccatgg tcagtgcgaa tcttctggga gatcgttttt tccggttaga 2981341 tccgcggatt ccgaacttct ccaaaacgga ccctgccgtc gttcccgctg tcattgaaat 2981401 tgcgaacaaa acaaacttac agcctgcgaa tcaatttata gagaagaact gggggagcaa 2981461 ataattattt attttaaatc aattctcgct tatacaattt tgtccgagag aagattctca 2981521 aaataaatac aggcaatggg tagaaccgga tttttttaaa ggtttgttaa tcacaagcta 2981581 ataagatgaa tgaaaaaatc aattcatact tcttcttttg aaagtgaggg ttcaaactaa 2981641 agaatgtaat tgaaatgtta ctctaaggta tgcaattccc tttttcacac aaaaaaagac 2981701 aagagcggca aatcgccaaa cccttgtctt tcctgttgtt ctattggacg cgctcggagg 2981761 gattcgaacc cccgacagac gtggtaccgg aaaccaccgc tctatccaac tgagctacga 2981821 gcgcatatag actgcgttat gagaacgtca gcacaactaa ttatacgata attcctttca 2981881 aataacaacc ctctatttcg agaggccgtt ttttaaatag acaaagcatc ttaattggca 2981941 atctgacata cgatggtttg aacccctgta tttttgggga aaatgggaaa aagagacgac 2982001 tttgcatatc aggccagctt tttgtttgac ctttattgac caaaaatgta tcatgtaact 2982061 acatacttac ctaaaaggtg aaggaggagc attatgaatt taatacctac agtcattgaa 2982121 caaacgaacc gcggggaaag agcgtatgac atttattctc gtctattaaa ggatcgtatc 2982181 atcatgcttg gatctgcgat tgatgacaac gttgcgaact ccatcgtgtc acagctttta 2982241 ttcttagcag cagaagaccc tgaaaaagaa atttctcttt acatcaacag cccgggcggc 2982301 tctattacag ccggtatggc gatctatgat accatgcagt ttattaagcc gaaggtatct 2982361 acaatttgta tcggtatggc tgcgtcaatg ggcgcgttcc tgcttgcagc cggcgaaaaa 2982421 ggcaaacgct atgcgcttcc aaacagtgaa gtcatgattc accagcctct tggcggtgcg 2982481 caaggtcaag cgacagaaat tgaaattgct gcgaaacgca ttctcttgct tcgcgacaaa 2982541 ttaaacaaag tcctagctga acgtactggc cagccgcttg aagtgatcga acgcgacaca 2982601 gaccgtgata acttcaagtc tgctgaagaa gcgcttgaat acggcctgat tgacaaaatt 2982661 ttgactcaca cagaagacaa aaagtaataa cacaacctgc aagagctgcg tctcttgcag 2982721 gtttttttca tttcaaggaa ttgactccct tattctatac tgctcccatt cctcatgtaa 2982781 cagctcaagc gtcaaatcac tcgtctgcct cacaaccaga tcagcaccaa gcatcggctg 2982841 tccttgaccg acaccaaccg caaacatccc cgcagatttg attgcagaaa tgcctgcttc 2982901 tgcgtcttct attgccgcgc aatcagcagg ggaaacatcg agcatcgctg cagctgttaa 2982961 aaagatgtca ggatcaggct tccccttcgc aagagtcgtc ggatcaacaa tggcatgaaa 2983021 atcatcgata attgccaagc gtcttaaaat cttaggagca ttgcgacttg aagatgctaa 2983081 cccgattttt atattttcgt ttttcaattg acatagaagc ctgccaatcc ccggtaaaag 2983141 atcttccggc gtcaatttgc tgatcagcat ttgataatcg cgatttttcc gatgcataag 2983201 ctcttgtttc tccgcatttg tatactttgt ttccgccccg ccaaagatca atatgctttc 2983261 aagtgactct tctctgctga ttccttttag cctttcattc atgtctctgt caaaagggat 2983321 atcgatttgt tctgcgatgt gcttccaagc gagaaaatga tattcagcag tatctgttat 2983381 cactccgtct aaatcaaaaa tgaccgcttt catatactaa tgcccatcac agcttcataa 2983441 ggtttgaggc taatactctt taagtcagcc cgctcctgcg gatagtttga aattagcact 2983501 ttccaacgct catgaatcag ttctggaggc gcttcgaaca gagccttttc ttccgataaa 2983561 ttcacaacga caagaagctt ttcccctcga tattctcgaa ggtaagaaaa gacctgcgga 2983621 tcattctcct gcaacagctg ataatcgcca tatatcataa tcttatattg ctttcgtaat 2983681 tgaatgagct tctgatagta aaagaaaatc gaatcttgat cttccaaaga ctctttcaca 2983741 ttgatatctt gatagcggga atttaccggt atccacgggt ctccggctgt gaatcccgca 2983801 tgttttccgg catcccactg catcggtgtt ctcgcatgat cccttccttt tatcatcacg 2983861 gctttgacaa actctttttc tgacatcgtt ttgttttcga cgactagttc acgatatgca 2983921 ttctttattt caagatcatc atacatctcc agcggcatat cgctgttgac catgccgatt 2983981 tcttctccct ggtaaataaa cggcgttcct ttcatgccgt gcagaaccgt tgcaaatgcc 2984041 ttcgcacatt ccttacgcag tttcctgtca ttgccccagc gggaaataac cctcggctgg 2984101 tcatggttct caaaataaag ggtattccag ccgacattca ttaacccggt ctgccacctt 2984161 gtcatcgtct tttttaaagc aatcaaatca aacggcttga tctgccattt cccatttggc 2984221 gagttttgtt ctttatcaat atccatatgt tcaaatgtaa agatcatatt cagctcttgc 2984281 ctgcttgcat ctgtgtactt tttcgcctct tcaatatcag agccgtttgc ctctccgact 2984341 gtcatgcagt cgtaatgaga aagcacttcc ctgttcatct cttgaataaa ctcatgaaga 2984401 cgtgggccgt tagagtgata acggccgaca atatagctgc ggctgtgatc cgtttcgtag 2984461 tccggaaaat cggtgtattt agaaatagag ccaatcacat ccatccgcca gccgtcaacg 2984521 cctctatcca tccagaatct cattacatca taaacttccc ggcgaacggc ttcgttttcc 2984581 caatttaaat caggctgttt tttcgaaaag tagtgcaaat aatactgccc tgttccttca 2984641 tcgtatgtcc acgctgagcc tgaaaagatc gatccccaat tattcggctc tgagccgtcc 2984701 ggtttaggat ctttccaaag ataataatcc cggtaaggat tgtccttcga cttgcggctt 2984761 tcagcaaacc aagcatgctc atctgatgtg tggttcacga ccaaatccat gacgattttc 2984821 attccgcgtt tatggacttc atcaatcagc tgaaacatat cttcatttgt cccaaacttt 2984881 tcgtacatgt ttttgtaatc gctgatatca tatccgttgt catcctgcgg ggaatcaaat 2984941 accggggaga gccagatgac atccgccccg aggtttttga tgtaatccag cttttgaatc 2985001 acaccttgca aatctccgaa tccatctcca ttggcatcat aaaaactgcg cgggtaaatt 2985061 tgataaacga cagcttcttt ccaccattca ctcattaggc gttctccttt cacatcgtcc 2985121 ctgtaggaca accggttcct cataaacgtt catgtgcagc ggctcgcctt ttacaagctc 2985181 aaaaataacg cgcttttcgt caaccgtcac attgattaat cgatttcgat aattgatgtt 2985241 gaatgaatat tcgtcccatt ctttcggcaa aaacggagca aatgacagcg tctcattcgc 2985301 ggtgcgcatg cctgcaaagc catgaacgat tgccagccag ctacccgtca ttgaagtaat 2985361 atgcaagcct tcttccgtat catgattgta attatcaaga tcaagccttg ctgtgcgctt 2985421 atataattcg agcgctttct tttccagctt gagttcggct gcgagaatcg catggacaga 2985481 gggcgatagg cttgattcat gaacagtcat cggctcataa aattcaaaat ttcgccgttt 2985541 ttcttccatt gtaaaacggt cattaaaaag ataaatgcct tggagaacat ctgcctgctt 2985601 aataaaattg gagcggagaa tcttgtccca tgaccaattc tggtaaagag gccgttccgc 2985661 tggatctaat tcgtcaactg tttgcaggtc tttgtccaag aacgtgtcat gctgaacgaa 2985721 aatttgcagt tcttcactaa atggatagta catgtgctgg atgatttctc tccagacttc 2985781 caattctact tcctgcacat ccagatggcg gcgtttctcc gctgagatac tttcgagact 2985841 ttgtagagta tactccaacg tccaagccgc aatgacattc gtataccaat tgttgttaac 2985901 gttgttttcg tattcattcg gccctgtgac gccatggatc atatacttat tttttcgttt 2985961 cgagaagtga acacggtcgg cccaaaatct gctgactgcc acaagtacgt ctatcccgta 2986021 ttcttccata tagttacggt cgcctgtata attgatataa ttgtagatcg cataacagat 2986081 cgcgccattg cggtgaattt cttcaaaggt gatttcccat tcgttgtggc attcatcacc 2986141 tgtgaacgtc accatcggat aaagtgcccc cttcatcccc aattttgcag cgtttcgttt 2986201 ggcagcctcc aactgatgat agcgatacaa aagcaggttt ttcgtcacct ccggctcggc 2986261 tgtcgccaaa tacatcggaa cggcgtacgc ctcagtatcc caatatgcgg cacctccata 2986321 tttctcgcca gtaaatcctt tcggcccgat attcaaacgg gcatcgcccc cgtaatatgt 2986381 cgagaataac tgaaagatat tgtagcggat tccttgttga agctcctcat ctcctttaat 2986441 ctcaatgtcc gcttttgccc atctttcctt ccatcgatca gtgtgcctcc gttttgcatc 2986501 ttcatagccg ttctctacca catccgccaa aagctccttg gctttcgata aaagctcttc 2986561 ctcccgaaaa tcacgggaag tcgtgacaat cacaaacttt ttcaatgatg ccttcgtttg 2986621 ataactgtag cgattctcga catacatttc agtcgtttta aagctttcat ggacaaaacc 2986681 ctccgtctcg tttgccattg cggctaatac cgtgaagcgc ggtgttccaa atggattttc 2986741 gatcgttttt gccgctaaat ggccgctgtg agaatcagca cctttcgctt cctcctgcca 2986801 aaactgttct tggtagttag aatcttcatt tgccacattt ccatccaggt aaggaacaag 2986861 cgtaatgaca gcatctcccg tcaagcactc cgcttcataa tgaatcgcac agagttcttt 2986921 tacagcaagg ctaagaaacc gctctgacct gattctgacg gttttatctt gaatgcggac 2986981 aacagcgctt cgccgcagaa tcccctcttt catattgagt tctacctcaa ataattcgat 2987041 tgggttttga tggagatcga ttttttcacc gtcaacatat aggcctatgc ccataaagtt 2987101 catcgcattg atcacttttc cgaaatattc tggatacccg tttttccacc agcctactcg 2987161 cgttttgtcg gggaaccaca cgcctgcaat atatgtgcct tggtgactgt cgcctgaata 2987221 gccttcttca aaattccctc tgacccccat atagccattg gcaagagacg tcaggctttc 2987281 cagcagccgt gtatgctcct tattaaatgt atttgttttg attttccatt catcaatctc 2987341 aaataaccgc tgatttatca tcatttcctc ccgaatgtaa gtttccatta tcacggcggg 2987401 ttttggtcaa atatctaaat gcaaaagaga tcatcaaagt aacgccacac gaatggatca 2987461 tcaatacagt aatcaaatca aaatgaacca tgccgatagc agctgccgca aatgccggca 2987521 gtgctgatgc gcaaatcgct atagaggccg cttccttgaa tgatgcaata gagaccatgt 2987581 ttgatatttt tgtgatccag aggccacctg caagaacaaa cgttaacaaa agctggatca 2987641 tagaaaccac cgtatatgcc agcatcatga tcatcggctt atactgtgcc aaccacaatg 2987701 tatcgatcaa gacctctaca tcatggacgt ttggtttctc gagcttaacg tccattttcg 2987761 catagccaac agaaaacccc gtttcgtttt gatcggtgat caccagttga tcaggttgaa 2987821 atatgatggc gttttcaaat ccagttactt tcaatcgccc attttcaccg cttgtctcat 2987881 attcatgctt catatcgact gccatcacat tctgcccatc ttcaatcctc tcagagctct 2987941 tcccgcctgt tagttttccg ttcctgattt gaaaaccctg caattgatca gcaaattgat 2988001 cattaactcc ttgaatcgct gacggcatga aagatgaaac gctgaagcga tccattttca 2988061 caaacgaaac cgctaacggc gccattaagc aggccgttaa aaacagaaag agaaaagaga 2988121 gctgcagcca gctgaaggta ttcccatagc ggcaaacacc tgatggggat gcagccgcct 2988181 tcaggcagcg gatgataaag cttttattct ccagattctt cattggcatt acccctttgt 2988241 tccgccggct gtcaaaccgg acacaaagtt cttttggaga aaaaagaata gaacgcatat 2988301 cggcagtgcg gctagtatgg caccggctgc aaatagagct actttttgct gctgcggatt 2988361 agaaataaag gattgtaatc ctacagcgat ggtcagcctt tccggtgagc gaagcagaaa 2988421 tttcgtcagc aaatagtcgc caaacggtgc cataaacgcc caaagcgctt gtaccgcgag 2988481 cattggctta acaagcggta gaacaattga agcgaaaatc ctcagatgtc ccgctccgtc 2988541 aattcgcgcg gcttcatcaa tttctctcgg cacagtatca aaataacctt tcatcagcca 2988601 cgtgttcatc ggaattccgc cgccgatata gatcgctgtt aaaaaccagt attgatcgag 2988661 tgcgcctatt agcatcgcca agacataaaa agcagtcagc gccgccattg tcggcaccat 2988721 ttgaatgatt aaaaagaata tcaggctctt ttttctgcct gcaaaccgat agcggctgta 2988781 cgagtacccg gcaagtgtca caatcgtaac ctgcaaaacc atgaccgata gcgcgatgac 2988841 aagtgtattg ctgtaccaat tgagataaag cgtttcgtca aatagccgct taaaatgatc 2988901 caatgtccaa gaacccgaaa aatcgagctg aaaagccgcc gaattcccca cacggaaggc 2988961 tgatgatgcc gtaatcagca acggatatat aatgacaata cttaaaagcg tcaaaaataa 2989021 atacgtacag attttattaa gcattctggc agtgctcgcg ttcacctaca taacctcctc 2989081 attgccaaaa gcattcgatt ttttgaaagc aatcagtgaa attccaatga caatgaaaga 2989141 aattaacagt gtcacagccg ccgcaacgga atattggggt gatgtgcctg ttgtcagttt 2989201 ataaatccac gaaattaaga tatcggtcga tccggccccg gctcccgcac tgcctggccc 2989261 tccctcatta aataaataga tgatcgagaa attattgaaa ttaaacgtat actgagtaat 2989321 catcacgggt gctgtggcaa ataaaatcat cgggaatgta atatgccgaa aacgctgaat 2989381 aaaagtggcc ccgtcaatct ttgccgcttc atacaattca cctggaatcg cctgaagcac 2989441 tcccgttacc atgacatata tatatggaaa gccgagccac gtttgaatca taatgagggc 2989501 tgtctttgtc cagaaaggat cggtcttcca cgcgatcgca ggcagctcga caaacggcag 2989561 gtgattgaat aatggtatca cctgtgcatt caccgctcct atgctgtcgt taaacatgtt 2989621 ggaaaaactc atgattgtaa taaacgccgg aacagcccat ggaaataaga aaatcattcg 2989681 aaatatccgc ttgcctttta taaaatcctg attgacgaaa agtgccgtca caatacctaa 2989741 aatgatttgc agcgttgttg cacagattgt ccagataacc gtccagccca gtacattcac 2989801 aaatgtttca cgataggagc caaggaaaaa aatatttaag aaatttttaa acccgaccca 2989861 gtcaatcaga cgattaggcg gaatatgata aaaatcatag tttgttaatg caacaaacag 2989921 agtcaccaaa accggaaaaa taatcacaaa caccatcatg atatatgccg gcagtgtaaa 2989981 tagatacgga aaacctttat cgcccgcatg acagatcata tccttggctg ttgtattgac 2990041 ttccaaaccc gccgctttca tagcggcggt cttacgtgaa tcatgaatat taaagatata 2990101 gaacatgagg aaaatcattg tcacgatcaa ttgcagcgtg ccttcaatca gcataaacag 2990161 cgagtgatct tcaccgggaa cacttcccaa tgtcatcaat ccggttagcg cctgtatacc 2990221 gaaaacgcat aattcaaaag caaacaagcc tgtgatggca agaaataaga gcccctttga 2990281 caactgctga ttcgcaatct gcccaagtcc tggaatgatc gataaaagcc ctgcctttcg 2990341 tttttgcttt gtaagtgtgt gatgtttatt catttttccg ccctctattc ttccggacgc 2990401 tatcccgccg ttttatttca catacttttc tttaatattt tcctttatga cgtttacagc 2990461 atcattcgct gatgtttgtg tcgatttttt tcctgaagct gcatcaaaaa ttaaactttc 2990521 cgctcctgtc catacttcag ccatttccgg aatatttgga gtcggcgttg ctgtttcata 2990581 ttgtttaatc acagctgacg tcagttcatt cttttgctca tcggctttct tccttgcagc 2990641 cgtgttggcc ggaacttcgt ttgtatcctc ataaaaagcg taagcattgg catcatttgc 2990701 agcatactca agccattttt cagccagctc gggctctttt gtatatttcg aggcaaccca 2990761 gcccttcccg ccagcaaaag gggcgtattc ttctccattt ggcaatgtcg gaatgggagc 2990821 cgctccgtag ttcaatttag cctctttata gttggcagct gaccaaggac cgccaatgat 2990881 cgcagccgct ttgccttcta aaaacatctg ctgaataaag tcgtctgcgc ttgaattgtc 2990941 ttgcattcct ttcggccaat atgtctcaaa ccatttctcc gcatatttca ccgcttctac 2991001 agccccttta ttgttcaggc cgatgtcccc ggaatctgtg ccgttttttc caaacacata 2991061 tccgccgtat ccagccaata agccgtacga catataaaag tcagtccatt ttgctaaaaa 2991121 tccggttgat tttccttttt ccgaagcaaa cgcgaatcga ggatcttccg ttaacttttc 2991181 aaggtcttta aatgtttttg gcgctgtttt taaaagatct ttgttgtaat acaaaataag 2991241 tgtctcaatg actagcggca ttccgtacac tttgccgtca actgtcacct gctgcatttc 2991301 tttatcacca aagctttttg tgttagatgg cttaatatca agtaaatgtc cttgttgtcc 2991361 caaaccgccg atccggtcat atgcagcaag cataacatca ggcgcattac ccgccgggcc 2991421 atcaagagga agcgcttcta actgttcgaa catttgcttt tcaacaattt ttactgtgac 2991481 atcattttct ttttcgaact ttgtttttat gctttcaatg tattctttat acgtttcttc 2991541 gacagacaca gtcagcacct ttttgccatc agagcttgct ggattttttg aacttgagca 2991601 ggcggcaagg ccgattgcca ggaatgatgc cgccaatatg gcgaacccct tttttaaaag 2991661 aaccatctct tttcctcctt ctatttacga aactataaca attgtattgt cctatagaaa 2991721 gcggttacaa caactttcga tttgttaccg ataacagaat gttatacagg ggcggcagca 2991781 ctcaaaatca aaaattctcc cggctgaacg gcaatgacat cgtgatgctg tagcggctgc 2991841 tctgtccatg catcacagat tttcttattc ctatcaatat tcaactctcg taaactgacg 2991901 tgttgaacca cattcccttg attaaagaaa taaatcagta ttttttcatc aagagtccgc 2991961 gaaaagctaa tgaaatcatt tttgtcgtcc agcagattcc actcaagatg tccttcagtc 2992021 aataaagtgt tttcctgctt gcgtaaagca attaaccgtt tcataaattg cagcatgtct 2992081 tggttttgct tctctttttc ccaaaccata catttccggc ataatggatc attttcgccg 2992141 ttcagcccga tttccgttcc gtaataaatg catggtgagc ctgtctgggc aaacataaag 2992201 gccagcaacg cgcgtgcttt cttctcatca ttgcggcatc tggtcaaaag gcgctttgta 2992261 tcatggctat ccagtaaatt aaacatcacc tcattggcct gcttcattcc attcatcaaa 2992321 tgtgcattga cacggtgagc catacgtgaa gctgagatcg tctggtcagc aaagtattca 2992381 atcataggct ctgtaaaagg gtaattcatc gccgcatgaa attcatcccc tctaagccag 2992441 ggttcggcag aatgccagat ctcacctaaa atataaacat caggcttttc agtagataca 2992501 gcctgcctaa atgtcttcca aaaaacgtga tccacttcat ttgcgacatc caaacgccag 2992561 ccgtcaatgt caaattcgcg aatccagtac aaagcaatat caagcaaata tttctgcacc 2992621 tcgggattag ccgtgtttag cttcggcata tcagctgtaa aagcaaatct gtcataattg 2992681 tcgtctgtga cgggaaaaga gtgaatatgg aaccagtcct tatagcggga ttgatctccg 2992741 tttttgacga catcctgcca ttgcggagac gcgcttccta tatggttaaa aaccgcatca 2992801 agcataattc tcatcccccg ctgatgcagc tggctgacca atgtacgaaa aagctcagga 2992861 tccccgaaat gcggatcaat agaaaagtaa tccagcgtgt cgtatttatg attagaaggc 2992921 gcggaaaaga tcggtgtcag ataaatgccg ttcaccccta aatcctctaa ataatcaagc 2992981 ttgtcaacaa ttccttgtaa atcccctcca aaaaaatcat tgacgtccgg gtccttgctc 2993041 ccccacggca atgcattctt cggtgacaag tcttctcttc catttgcaaa acgctccgga 2993101 aaaatttgat accaaaccgt tgacttgacc cattcaggcg cttgaaatgt atcagcctcg 2993161 tgaacaaacg gaaatttaaa gtaataatga atcgtttcca gtgttttttc gttataaggg 2993221 catacacccg aacttccgaa aaagatgtct tcatgatcgt ctgttacaac aaacgcatat 2993281 tgtaaacgcc taaatggcgg caccacttca gcaaaccaat agtcatgcat ttctgtagca 2993341 gcaattttcc tcatcggctg ctcgtttgcc gaccatttgc cgtcgttgta ctcataggga 2993401 tcaccccaaa tgaatcgaat gtgatctgca tcaccttttt tcgtccgaat cttgatatgc 2993461 acagtccgcc catcataaga ataagcatct gtgctgaatg gctggtgatg aatcgctgca 2993521 tattccatca tgtttccccc tttgatttcc gttttattga agccggctca tagtttgaaa 2993581 gtatcatgat gaaattgtgg gaacaatcct tttcaccctg ttaccgataa cagaataagg 2993641 cgcttacagc gttgattctc gtacaattaa ctctggttca aaaaatagac ttccttgtgc 2993701 agcgccgtct tcattcattt ttttcagcaa cattttcgca caggcttccc ccatttcaac 2993761 aacaggctgt ctgaccgtag tcaagcgcgg cgaggagatg cgatcaagaa acacaccgtc 2993821 attcccggta accgcaacgt cttctggaat tcgctttcca agggattgcg ccgcacgaat 2993881 gacgccgagc gcgattcgat cagatgcgca gacaaatgcg gcctgattgt ccatggattt 2993941 cagcagttct cttgcaaggc attcactttt cttagaactg ttgtcgatcc gaaacatatt 2994001 cgatttttta aagcttttat tcatcgcccg tatatacccc tgttctcttg cacgttcgaa 2994061 aggctcatct aaatcaatgc caaaaaagac aacttcccgc tcccccagcc ccataacatg 2994121 gcgggttgcc ataaaagtgc ctttctcgtt attcacatcg ataaagtcat agcccatttc 2994181 attttgtcca aatacgacga gcggcttctc aaaagctttt attacacctt caaaatcgtt 2994241 ctttctcaag ccggtggcaa taatgccgtc acattggcca atattaagag aatttcttgt 2994301 cacaagctgg agagcatagt gattgcgatc cagctccctg ctgattcctg tcagcaggtt 2994361 catgtaatat ggttctgtcg tatccatttc ctcaagtatc aatagtttca caacctgtgt 2994421 tctgttttgc acgagcgctc tcgccgcata attagggatg taattcagct ctttcatcgc 2994481 agaatgaaca agctttttca attcatccgt caccgtctca gggtgattga tcactcgtga 2994541 taccgtcatt ttcgaaacat ttgctttttt cgccacatct gacaatgttg ccattttcat 2994601 cccctcctta tctgtgctta ttatccaaac tagtgataaa gtcctctatt actgctaaat 2994661 atacgatgca ggccaaagag aaataaaaaa gagatttccc ttaaggaaac ctcactttgt 2994721 taaaaacact cgatttttca tggattcata cgctaggtgg cagactcatt ctctccactt 2994781 ccatcagaaa atctcttttt taaatttctg tccacttttt ttctaaaatc ggataagaat 2994841 aattttgcat ttgctcaatt aactcatccg gccgtgacga gctgtgaatc agttttaggt 2994901 gcgattcgtt agaaaaccct tcttgaatgc tgtatttcac cattttcatc attggttcaa 2994961 aatatccgtt tacattgtac agtccaattg gcttttggtg gatgccgatc tgtgcccagc 2995021 acagcacttc aaataattct tcatatgtac cgaagccgcc cggcatcgag ataaagccgt 2995081 ccgccagctc gctcatttta gcctttcgtt catgcatccc gtttacttca atcagctcag 2995141 tcagattctg atggacaacc tccccgctga acaaaccgct cggcatgacc ccgattgcag 2995201 ttccgccgtt ttccataatc gcgtcagcaa tcgtgcccat caagcctacg cgggagcccc 2995261 catagacaag gccgattccc tgctcagcca tatacacgcc aagctctgcc gcttttcttt 2995321 tatacgcttc atttccccca gggtttgatc ccgcaaatac acaaatggtt ttcatcttgt 2995381 catctccgca tctatatatc gtgttaaaca ttcaaaaaca cactatatat tgtcccatct 2995441 tcatgtgata atatcaatat gaaatacata aagaatgcag gagtgatgag gttgcagctg 2995501 gctgatgcag aaaaatggat gaaagagttt tacgaaaaaa gaggctggac agaatacgga 2995561 ccttttattc gcgtcggctt tttaatggag gaagccggag aactggcccg ggctgtcagg 2995621 gcgtatgaaa tcggcagaga ccggccggat gagaaagaat cgtcacgcgc tgagcaaaaa 2995681 caagaattga ttgaagaaat gggagatgtc atcggaaata tcgccattct tgctgatatg 2995741 tatggtgtct ctttagaaga cgtcatgaag gcccaccaag aaaaactgac aaaacgattt 2995801 gagcatgcat aaaaaagcgg ccgcgatggc cgcttttttt aacctgtgat ttcatcatgg 2995861 tgatcaaaga aatgctgctt tcctattttg tgaaaaaggc ctgttttatg cagtagctcc 2995921 ttcggctgcg attgcaatcc tacaatcatc agctttccat tgtggcgttt aattcgattc 2995981 ataatgttcc caagcaccgc ttcagctgac gtatccatat agtgcacctt attcatgagc 2996041 agaataaggg ttttcggttt tttctgtaca tgctccagca atgacgattc aagggaatca 2996101 attgatccga aaaacagcgg cccttctatg gcatacatgc tgacagatgg atcttctctc 2996161 ttcgccagaa caggatgcgt ttcctgattg tggatgcggg tcgcttcgct cattcttctg 2996221 ataaagaaca cgaatgcaag cagcaatccg gttgccacac cgatgattaa gtcaaacaga 2996281 accgtaaggg cgaaggtcgc cgccaaaata aaggaatcag catttttcag tctcagcatg 2996341 tttgcgactt ccttgcgctc actcatattc catgcgacca ccatgagaat cggtgccata 2996401 ctggcgagcg gcacatggga cgcataaggc gcaaatacaa gcaggacaag gagaacgact 2996461 acgccgtgaa cgacgccgga aactggggaa accgctccgt tttttatatt ggtcgccgtt 2996521 ctcgcaatcg ctcctgtagc cgggattccg ccaaacaggg gcgctgccat attcgcaatc 2996581 ccctggccga caagctcctt gttgctgtca tgctttgagc ccttcatgtt atcagcgacc 2996641 attgcggaca aaatcgactc aagtcctcca agaagcgcga tgacaagcgc agccggaaac 2996701 agcataacca ttttatccaa agtaagctca ggaaactgaa attccggcaa atggcggggg 2996761 atttctccat aagttgaccc gatcgttgcc atgcggtcag ggaaaaagac aaccgcgacc 2996821 actgtggaaa taagaagcgc caacaaagcg cccggcactt taggcatcac cttggcggat 2996881 acaagcaaaa tgacgagccc gatcacagct gtcaaaatgg catacacgtt aaaggtgccg 2996941 agctgctgca caatttcaaa catgttgtga tgaaagttct catgtttttc aacatttctc 2997001 aatccgagaa aattagcgat ttgttccgta aagatcagca cggcaattcc ggctgtaaaa 2997061 ccgacgataa cgggtttggg cacgaatttc attatttttc cgagcttaaa cagcccaaac 2997121 agtaccagca tcactcctgc cataaacccc gcaatcagca gattttccaa gccgtactgc 2997181 atgataatgc cgaataaaat cgggacaaag gcgcccgtcg gaccgccaat ctgatatttt 2997241 gatcctccaa acaaagaaat acaaatccct gctataacaa cagtgtatag cccatattca 2997301 ggctcgactc ccgaggcaat ggcaaacgcc attcctaaag gaattgccac gacacctact 2997361 acgatacctg caatcaagtc tttctgaaat ttctgcaaat tgtatccctt gaatctccct 2997421 gagaatcgca tattttgtta taacctccct tatgagtgat tgtttataag ctcagtttca 2997481 taaccgttaa tgaccacatc aagttttcct gtttcagggt gaatgacaag cccgtgaacc 2997541 ggcacttttt tcggaagcag cggatggttc ttaatcatgt tcacactgtg ggaaacgctt 2997601 tcttccacgc tgtgaaaacc agtcagccac gttttcaaat cgagtccggc actcgtcagc 2997661 aaattcaggc agctatcctc caccccgcgt tcctttgctt tctcaagaat cgaggacgca 2997721 ttcagccctg acattccgca ttcatgatgg ccgacaatgc atacctcttc agcctgcaat 2997781 tcataaatcg cgaccagtat gcttcgcatc acgcttccaa atgggtgaga aacgatggct 2997841 cccgcgtttt ttacaatttt agcatcaccg tttttaagcc ccattgcttg cggaagaagt 2997901 tctgtaagcc ttgtatccat acaggtgaca atgacgagct ttttcgaagg aaactttgtc 2997961 gttttgtacg gttcatactt cttctcactg acaaaccgct gattgtgttc caaaattgat 2998021 gttaaagaaa ccatttgatt catctcccat ccatatgatt ttgcaagcct tcttacccag 2998081 cttacagtaa ggaattatag cataggaata agccaagaaa aggttttcaa aaaaagacac 2998141 tataattgga ctgtagaatc aaaacataaa catttatatc tttcaaagat aataaaattt 2998201 atatttaatg catcctataa tccggctgca gttcgtatat cgatgatttg tctgacaaaa 2998261 aatatgggtg aattctgata attaaaaaac ttttttaagc agatttagct gttcgatctt 2998321 cattttaagt tcaaaagaac cagaaattaa aaaaacgcag ctatattttt aacatctatt 2998381 tattttcgat ataatgaatt agacaacagc cataaagggg gagccttgtt gaaaccattt 2998441 gtatttatca caaaaccgat tcctgaagag attgaagcat tcatcggtga acattgccgt 2998501 tatgaagtat ggcaggagga tacgcttccg agtgacgtgc tatttgaaaa attaaaagaa 2998561 gcggaggggc ttttaacatc agggacgtcc ggaccgtcaa tcaatcgtga gttgctggaa 2998621 cacgcgccta agctcaaagt ggtcagcaac caatcagtag gctacgataa cttcgatata 2998681 gaagcaatga aagaaagagg agtcgtcggg actcatacac cttatacact ggatgacaca 2998741 gttgcagatc tggctttttc actgattctg tcttccgcca gacgtgttgc cgaactggac 2998801 cgttttgtca gagcaggaaa atggggaacc gtggaagagg aagcgctttt cggaattgat 2998861 gttcatcatc aaacgttagg cattatcggc atgggcagaa ttggagaaca agcagcgaga 2998921 cgcgccaaat ttggttttga tatggaagtg ctttatcata accgacatcg caaacaagaa 2998981 acagaagaca gcatcggcgt taagtatgca gagcttgata cattgctgga gcaatctgat 2999041 tttattcttc tcattacgcc gctgactgat gaaacctatc acatgatagg agaacgcgaa 2999101 tttaagttga tgaagaattc agcaattttc gtcaatattt cccggggaaa gacagttgat 2999161 gaaaaagcac tgattcgcgc tcttcaggaa ggctggatca ggggagccgg cttagatgta 2999221 tacgaaaaag agcctgtcac ccaagataat ccgctcctgc agctggataa tgtcacgctg 2999281 cttcctcata tcggttcagc aacagctaaa gtgcgcttca acatgtgcaa acaggccgcc 2999341 gaaaatatgc tcgcagcgat ccaagggcaa acaccgaaaa atcttacaag agaatttcaa 2999401 taaatcaaaa atccggtctg ataacagacc ggatttcata ttacatacgc tgaagaacag 2999461 cacgcttata aatatgacgg gtgacgatat aataaagagc ctggaataca aaataaatga 2999521 agatgacaat tacggcctca agaaataaat tggaattcag catattactt aacgctgcat 2999581 acgcaaagcc cgcgtgaatc gtacctgcga taaatgggat gaagaataaa aatcctattt 2999641 gctttccaag gatcgagtga atctctttgt ccgtaacccc tatcctcttt aacgctaaca 2999701 cctgcactcc cgtatcttct atttccgtaa acatccgcaa atacagcatg cttccttgca 2999761 cgataaaaaa cagcacgctg acaaacagac caataaacag cattaatgca actccctgct 2999821 tcacaatttg ataactagga gcacgtgttt gaaaatcaga tgtatgttct ttcggcacca 2999881 tgttttcaag cttttcagag acatccaccg tctcctgcca atgctcaagc tcataaccta 2999941 ccattctcat ctgttccttc agcggcacat cctgtgacag actgtcaaag ctcttttcgc 3000001 tgacaaccaa taaacggctg actccatcga cagacatcaa tatccctttg ttttgctgct 3000061 ttttcatgac ataggaaagg gtttttcctg acttcatatg aaatgctgct gtttcccctt 3000121 ctccaaatgt gtctttcacc atcatttgaa aagaaacatt aataaatgct tcattttctt 3000181 gtaaatgaat aactgggaac cctttttcct ttgcgacttg attatagact ttttctgaaa 3000241 tcagcaaagc ttcagcttcc atcttcttat ttccatacgg caagtctgac tgaaaagtga 3000301 caggaatccc tgtggcatcc accttatacg tgataacagc atgagctttt ttcaatgtat 3000361 tctcagccgt ctcaggcttc atgacctgaa agcgggaagc atccttttcc acccaggaaa 3000421 cagactgagg aatgctttgc tcctcctgcc tttgtaaatc ggaataaaac atatagatga 3000481 cacctgtagc tgttagtatg accgctgtaa tgacagaggt taaaaacagc atgcgtgcat 3000541 gatccttcag cctgaatatc atgttggaac gcacaatgat atttgtgcct ttgtagaagc 3000601 tgtgtttctt tcggtacagc atgcggaaaa atgccacact gctttgggta aaaaagaaat 3000661 acgtgccaat taacactaaa atcaaaattg gaaaaacccg aaacatcatg tcaattgcat 3000721 tggctgttgc agatagataa taaccgctgc caagacatag caaagacaat acagtgagcc 3000781 atttcgaata aactggcaaa cttttcggct ttttggctga tttaatcagt tcaatgattt 3000841 ccagcttccg aatccgtccc agtgataaaa tgagcagcgt ctgaaacagg atgagaaagc 3000901 cggcaattgt catcacaaac gctttcggca caatggcaaa cgaaatcggc accttcacgc 3000961 tgagcatcca tgtcatgatc ataaaaaaca gttttgaaaa taacaggcct gctccaatgc 3001021 cggccgcaat cgccgcaaga gaaataagtg actgctcata ataaatcatc ttgcgaagct 3001081 gctgctttga tgtgccaaac agtgtcagca gcccaaactc tttctttctt gcctgcaaaa 3001141 acgctgaatt ggaatatgtg atgaaaaata tacaaaacac aatgatgacg acaagagctg 3001201 cgctcaagca tgttttgaca aggcttcctc catatatatt gtcttcattg acatcaggat 3001261 gaaaaataaa tgatgtgaag acaaaaaaca ccgaaacggc aaacacacag cttaaaaagt 3001321 aggccacata ccgttgcaga ttcccaagaa tgtttttacg ggcgatagtt ctcaaattca 3001381 tgaaaatcgc ctcccaacac actcaaggta tccaatatac tttgataaaa cacctgcctg 3001441 tttgttcctc tgtgaatctc tgaaaagaaa cgtccgtctt taataaaaac aatccgttta 3001501 cagaaacttg ctgctgtggc atcatgcgta accaacaaaa tcgtcgcttc cttttcctca 3001561 ttcagctgag ccagtgtgtt catcacttgc tttgccgatt ttgagtcgag gtttcctgtc 3001621 ggttcatcgg caagaatgag cgccggattg tgaataatcg ctctggcaca agctgcccgc 3001681 tgctgctgtc cgcccgacac ctcatatgtg cggtgatcga gaatatgctt tatttgcagc 3001741 gtatccgcca gttcatccaa tcgagcttcc atttctctca gctttacctt atccaatgcg 3001801 agcggcaaga gaatattttc acgaatcgtc agcgtatcaa gcagattaaa atcctgaaag 3001861 acgaagccga gttctcttct gcgaaacaaa gccagctctt ggtcctttaa cgttttcggc 3001921 tgaatgccgt tgatcatcat ctcgccctgg gtcggcttat caatggtagc cagcaaattc 3001981 aaaagcgtgg tttttccgct tcccgacggc cccataatcc cgacaaattc tccttttgac 3002041 acactgagat caaaggcgct gagcgcttgg tatgatattg ttcctttatt tgaatagtat 3002101 gttttcgata ggttcgttgt ttgcaacacg ttcatgttct gctcctcctt tttctttatt 3002161 ataaaaagga agtcagcatc ctcccatcga actttcttgc aattccgctc cccaatctta 3002221 caatgctgtc acattcacga gggtgtcact tgaaaacacg atggtcatca cagtgccagc 3002281 cccttctttt gattccgcat acagcttatg gccgagacgg ctgcacacct gttttgctaa 3002341 ataaaggccc attccagttg cctctttcat ggttcgtccg ttttctccgg taaaaaacgc 3002401 gtcaaaaatc cgcggcagat cctgcggcgg tatgccgatt ccttcgtcgg caaccgacaa 3002461 gcgcgtctca tgtccctgtg tttcaatccg gattgtaata gggtctccca caccttgctt 3002521 tgaatatttt aaggcgttga aaaggatttg ctcaacaaca aaggaaagcc acttttgatc 3002581 actggaaatc tgaacggcat ttggcggcac atgtaatgtt ggaaaaaggc gccgcttgat 3002641 aaactgacgt ttttcctgat tgatcagtga acgaaccatt tctgccaaat caaaggtttg 3002701 cggctttaca tcaaatgcaa attcctccag ccgggccgtt tgcagcatca tatcaagacc 3002761 gtggcgaaat ctctcattct catcctccag ctcctctaaa aacgtcggaa aagaggatga 3002821 ggttccgttt tttccttcct gaatcattaa ggatatgaca gataccggtg ttttcatatg 3002881 gtggacccat tggttggtga aggtgtaatg ctgtttttgc tgattgatat attgtgagag 3002941 cctgctttcg tattgctgcc cgagtgcgtt gatcatcttc gtccaaagcg cttgctctcc 3003001 tgttcttggc tttctggctt tcaaagactg tccgatgtca ttcgaagaag aggcttgttc 3003061 tgcaagcttt ttaacatatg tgagaaagga aaattgccga acataatcag cagcaaaacc 3003121 tgcggctaaa agagtaccgg gcaaaatcca tatgtacatc atattttctt tggaaggttc 3003181 tgcgccgctc tctacaatgc ttaaatacgc aatcagcatg gcggacccta tccctaataa 3003241 tgaaaataga ataatggcta agcggtcgat gagataagtc tttaacattc cgcttcatcc 3003301 ttccgattga cttgaaattg ataaccttgt cctctgattg tggaaatgca atctgtcagt 3003361 cctgcattct ccagttttct ccgcagccga ttgacattga ccgttaacgt attgtcatcg 3003421 acaaaatcaa cgtcatccca taacgcctcc aatagttcat cacgagagac aattttttta 3003481 tgctccctca caaaaatcga gagaagctgg aattcttttt gggaaaacaa aatccggacg 3003541 ctgttccatt cggcctcatt ctgatcagga taaatcgtca gcccgccaag ctccactatt 3003601 ctagattcct gcggcaaaga gggcgaatat tcaccatatg tgcggcgcag gacgcttttg 3003661 attttggcca tcactacctc tagatggaac ggctttgtga tataatcatc gccgccattt 3003721 tcaatcgcca ttacctgatt cagctcatcg gtccgtgccg atataaagat aatcggcgca 3003781 ttggaaatgg tacggatttg cctgcaccaa taaaacccgt caaaaaaagg caggttgata 3003841 tcaagcagca caagatcagg cttcatttct gcaaattcca attttatatc attcagctgt 3003901 tcagcaattt tcacttcata tccgtatttt tgaagatgac cgcccagcaa agaagcaatc 3003961 cgctcatcat cttccacaag caaaatccga tacacgttga tcccccttat atgtacatca 3004021 cgatgatttt tctagaagat tccaaaatta ttatagcatg tgcggaatag taaatcggtc 3004081 tttttctttt tgttatgata gaatgataaa ggtaaaattt tcataatagg caggtgtcgt 3004141 gatgaagaaa atcatgctgt ttctggcaat gacgtcaatt ctttcagcat gtcagcccaa 3004201 ctataccggg aaatacatag aaattgggga tacactaact gactatacca aagagtgctt 3004261 taaagagaat gaaattcctt ataaatacga aaagggaaaa ctgtatatcc cagaagacgc 3004321 atttgataca gcaatctaca cttgttcata agaaaaagct tgcagataac ctgcaagctt 3004381 ttcacgttac aaaaaatgag tatttaattt ctcttcaaat cctgaagggc cgatgtcgct 3004441 tttttgaatg ttaccgccgt tttcataaat cgtaaaatgg cgctctgaca tgaccatcct 3004501 tccgctcggc gtcagctttg aggcaagcag ggatttgtta aaaggagatt tttcatgaga 3004561 gtgaatgatg tccttcatgt tatctaaatc accgagatca ctctcttcaa gggtaaaggc 3004621 gtacccaatt tgccagcctt ctcctttgtc catcagcaga acatagctgc ccttttctgt 3004681 ctcttccttt ttgattcgga atgacccgac tggtgactgt accgtttctc cggaaagcgg 3004741 tatcggctgg agcgccaggt tgatgccgaa gccgatatca acgaggtaat cgccgttttc 3004801 cgcagacagc catacagcag catgcgtccc ttctagtgcc catccctctt gatcgcctgc 3004861 ataaaccgtt cctcgaatga gcttcacatg aaacccggcc tcacgcaaga caaaataaag 3004921 gaaaccattt agatcgtagc ataggccgcc gtgctgatct ttgagcagac gtcgccatag 3004981 ctcttctttt gtgatcttat aattctcttt tgcaagtacg gcacggtttt cgaatggaaa 3005041 acggtatgcc attgctttaa gaaaaagggg aagatcgccg aagctgacat ggtctttctc 3005101 ccagccgatt ttctgaaagc agtcttttag aaagtcactc atttttatca cctaaacttc 3005161 ttcttgaacg taagcagcca gcttctccag cgcctcttgt tcatcttctc cctgggcaat 3005221 caaggtaacc tcagtgcctg tgcttaccgc aaggctcatc agccccatga tgcttttggc 3005281 gtttactttt ttcccatcct tctcaagaaa cacatctgac gtaaaccggt ttgcttcttg 3005341 tacaaacaaa gcagcaggac gtgcttgcag tcctgtcttt aatcgaactt ccactttctg 3005401 ttgaaccata agatctcccc ttttctttac ggttatttta aagtgacggt ttgccctgtc 3005461 cgcagctgtt ctgcgatttc gtcaagtttt ctcagcctgt gattgatccc tgatttgctg 3005521 attttcccgc ttgctaccat ttcccctagc tctttcagcg tcacttcctg ataatcaatc 3005581 cgcagctgcg caatttcccg aagtttttca ggcagcgcct ccaggccgat tctttcatcg 3005641 atgtatttaa tattttccac ctgtctcagc gatgcgccga tcgttttgtt taagttggct 3005701 gtttcacaat tgacgaggcg gttgaccgaa tttctcatgt cccgaacgat tctgacatcc 3005761 tcaaatcgca gaagcgaatt gtgagcgcca attacgttca gaaactctgt aatcttttca 3005821 gcctctttta aataggtaat atagcctttt ttccgttcaa gcgttttgct gtttaactga 3005881 aactcattta acaggtcaca taatgaatcg ttatgctcct tataaagaga gaagatttct 3005941 aaatgatacg aggaggtttc cgggttattg accgaacctc ctgccaaaaa tgctcctctc 3006001 atataagaac gcttgcagca tctctttttg accagctctt tcgaaatact tcgttcaaac 3006061 acaaaattct ccccgagtat ttttaaatcc tctaagatcg cttttgcatt ttctgaaaaa 3006121 cgcacaatat agacgttatt ctttttcagc cgcattttct ttctgaccag cagctcgacc 3006181 gacacatcat attgtttttt cagcaatgta tagatgcggc gggcaatcgc cgcgttttcg 3006241 gtttgaacat cgagtacgag atggcggttt gtaaatgata aagctccatt catccgaatg 3006301 agtgcagaca gctcggcatt aatgcagcag tccttcactt ccagattcgt taattctttt 3006361 tttgtttctg atgcaaatga catatagcca cctcatttca aggcttcatt ctttcagtaa 3006421 atcaacaaga agagaggcca ctttatgtgt atcgtgacgt attacgtcat ttttatacgt 3006481 tacaatttga tctctgatga cttcaagccc catcgctttc agctcttcga tatcaaaatc 3006541 aacaggacgc gccgattcca tttcgtactt acgttttatt tcgtcgggaa tgtcttcact 3006601 gttcactaat atcgtatcaa taaaaccaca gcccatatgc tgattgagcg ctttcacatg 3006661 atcagcagcg gtgtaatgga gcgtttcgcc gggctgagtc atcacgttgc aaatgtatac 3006721 ttttttcgcc ggcgccttta tcacttcttc cccgattttt gggacgagca aattgggaag 3006781 aatgctggta tagaggcttc ccgggccgat aataatcaaa tccgcttccc tgattacgtc 3006841 tattgtttcc ggcagcggat caatctgttc aggcgtgaga aaaacacgct taatgcgctg 3006901 tccgtattct gggatcgttg actcgcctga gaccacgcgg ccatcttcca tctcagcatg 3006961 caaaacgaca ctggcattgg cagccggcaa aacctttcct cttacattca gcaccttgct 3007021 catttctgtg acagcgtgaa aaaaatcacc ggttatattt gtcatcgctg ccaaaatcaa 3007081 attcccgaga gaatggcctg ttaagtcatt ccctttattg aagcggtgct gaaaaagatc 3007141 ttcaacaagc ggctccacat cggataaagc ggcaagcaca tttctgatgt ctccgggagg 3007201 cggaattttc agttcattcc gcagacggcc agagctcccc ccatcatcgg caactgttac 3007261 aatggccgtg atgtcaacgg gtttatgctt taggccccga agcaatacag aaagacctgt 3007321 accgccgcca aagattgcga ttttcggctt ttgtcccatc ttatttccgg cttctctttt 3007381 caatgtcccg gtgagtaaca tgagtatagt aatccttttt gaaataatca gctaaattct 3007441 cggctaatgt cacagagcgg tgctggcccc ctgtgcagcc gatcgcaatg acaacctggc 3007501 tttttccttc tcttttgtaa gatggaagca taaagctcag cagatcaatt aatttctcat 3007561 tgaacttttg cgtttcattc cacttcatga cgtaagagga aacctcttta tccttgccag 3007621 tcagcggccg catgctttcg atatagtacg gattcggcaa aaatctgaca tcaaagacga 3007681 gatctgcatc aattggaata ccgtatttaa aaccaaatga catcacattt acggtaaatg 3007741 tctctccttg gtttgtcgca aagtgcttca cgattttttc acgcaaatca cgcggcttca 3007801 tgtcagacgt atcgtaaatg atttgagagc ggccttttaa ttcctcaagc agctctcgtt 3007861 ctagcgcgat gccttcaagc ggcaggccag tcgctgccag cggatgcgag cgtctcgttt 3007921 ctttatatct tgtgacgaga atggaatcct tcgcgtccag gaataaaatt cgcggtgtga 3007981 tccacggatt ttcggccatt tcatccagcg cttcaatcag ccggtcaaaa aattcgcggc 3008041 cgcgcaaatc catcacgagc gcaactttgc tcattttcga atttgattcc ttcatcagct 3008101 ctaaaaactt cggaagcaat gaaggcggaa gattatcgac gcagaaatag ccgagatctt 3008161 caaagctttg gatcgcgaca gttttccccg ctcccgacat tccagttata atgacaagct 3008221 gaatatcatg tgattcacta acactcatct ttctcccccc tgacttgtct ttctatttga 3008281 tgtgctgcgg gtctaaacga taactgagca gctcaaattc cggtgtatac gtaaatgtgc 3008341 cgtgcagcag cccttgtccc ttcatcataa aatcaaggat atggccgtct ccaggggcca 3008401 taggcaggtt ctgaatgtca ttgacatcgt gccactgcag tttgccttcc tctgattctg 3008461 atacattttg tcctgtatat gaatcagcga caaacgtaaa catcatccac tcggagacaa 3008521 tgtggtcacc gtctttaata ataaaggtaa aaacgccttt taattgagga tttatgatat 3008581 agataccagt ctcttctctg tactctctga tgacggagtc tctgactgat tctccgctct 3008641 ccatcttgcc tcccggcgcg acccaccatc cgcgtctcgg cttttgaagc agaagaactt 3008701 tgtcatccgt ctgaagcaca caatttgtca ctctttgcaa gtacgtcacc taaccttcgt 3008761 cctgtcatcg tctctttatt ataccgcttc aagatgcctc ccacaatgaa gagacattga 3008821 caatcttttc ttctatttta cagcatattc attccttaat tcagatgatt ttgctgtaac 3008881 tggaattctc ttttatttat ggacaaaaaa aggacacgga taactggaga atccgtgcca 3008941 aaaaagtgta ttcattataa aaagggggtc aattacttta ttaatcataa ccgaaaagca 3009001 ttacacatgt gttacagcgg aattaaaacc cagtaacgta atgtgaaact cgtatgacag 3009061 ccctttttat tttaaggttt tcagcgtttc ttggagctct tcgacataat gttgtacgct 3009121 ttgtgccgca atgcttccgt ctcctgtagc cgttacgatt tggcgcagtg atttttcgcg 3009181 gatgtctccg gcagcgaaaa tcccttcaac cttagtttcc atgcggtcgt ttgtttcgat 3009241 atagccttct tcattcgtaa tgcccaggtt ttcaaacggt ttagacagag gaagcatgcc 3009301 gatgtaaatg aatacgccgt ctgttttgaa ttcactttct tcaccggtta ccgtatcgac 3009361 aagcgttacg ttaccgactt tgccgttttc ctcatgaatt tccttcacag ttttgttcca 3009421 taggaagtca actttttcat tatcaaatgc tctcgcttga agaatacttt gagcacggag 3009481 tttatcacgt ctgtgaacaa tcgttacttt tgaagcgaaa cgagtcagat atacgccttc 3009541 ttcaaccgcg gaatctccgc cgccaacaac gacaagttct ttgcctttaa agaaagcgcc 3009601 gtcacatact gcacaataag atacaccgcg tccgcccaat tctttttcgc caggcacgcc 3009661 gattttttta tattccgcac ctgcagcaat gatgacagca cgggctttat attcctttga 3009721 accagctttg actactttgt actctttgcc gtcaatgacc tctttaatat cgccataagc 3009781 gtattcagcg ccgaattttt tcgcgtgttc aaacattttg ttagaaagct caggcccaag 3009841 gatactttcg aatccaggat agttttctac atcttccgta ttggccattt gtccgccagg 3009901 aattcctctt tcaatcatta atgtcgataa attcgctctt gatgtgtata cagcggccgt 3009961 catcccagca gggcccgcgc cgattataat cacgtcataa attttttctt ctgacacact 3010021 attcactcct taaaccatct tttcaagttt gggctctttc ttataagata agaatcccca 3010081 tcaaacgtat tccttaccca tatcctataa aatctcatgg tgatacgcta tttttttgct 3010141 caacacgatt aaatgtattc gaaaagggta tatgttaata aagaaagagc cttctgttta 3010201 tagaaggccc ttgtcatatt tattattgaa caacacgtct tacaacacct ttaaatgctg 3010261 ctttccagta aggattgctc atagagtcaa cagatacgcc atgagatgta ttgtcgttta 3010321 ggaaagtacc gtttcctaag tagattccta cgtgtccatt tgttttgtaa gtgtcaaaga 3010381 acacaaggtc tccgcgtttc atttcagacg cgctgacagc ttgtcctctg ccaactaacg 3010441 tatcagttgt tgttccgcct acaggtccaa ggttaacacc tgcagaagcg tatgcccagc 3010501 gtacgaatga tgagcagtca aaaatacggt tgttgatatc agactgagtg cgtccgccgc 3010561 caaacttgta cggagattgt cctacaatgc ttgaaccaac gctgatcgcg ccttcaattc 3010621 cgccagagtt gctgataaca gtgccgcctg aattgctgtt tgagccgctg ctcttcttag 3010681 aagatgagcc gtttgacgaa ctgtttgatg aaccgttaga agaattgtct gaagaattgt 3010741 ctgaagaatc atcagatgag cttgcttttg atgattcagt tgtcgccgtt tgactgtcat 3010801 ctgtttgtgt ttcatcagat gctttttgtg cttcttcctg ctttttgatc aaagcagccg 3010861 ctgcttcttg ttcttttttg atgcgtgctt gttcagcttc agtatttgct ttttgatttg 3010921 caagttcaga cgcctctgat tttaattcag aaatcgcttt agccgttttc ttttggcttg 3010981 cttttgcttc gtcgaaaagc ttgtcttttt cattaagctg tttatcaagg tctttttgca 3011041 ttgtttctaa tttagccaag gcagcttgaa cttctttcag cttgtcattc aaatccgctt 3011101 cagaatcttc gagcttcgct ttatcctgct cttgctgttt gattaaatct ttgtctgcgt 3011161 ccacaataga tgaaaccgca gtcgcacgag agataaagtc accaaagctt gttgatccta 3011221 aaagaacatc tatgtatcct tgagatccgc cgctttcctg taaagaacga acgcgttttt 3011281 tcaggatttc attgcgtttt tcgatgcgtg cttcagtttc tttaatctct tttttcagtt 3011341 ttttgatttc ttcttttgtt ttatcgtttt cttctttttt atcttcaatc ttgttgcttg 3011401 tatcaagcgc cttatcgtta atgtctttca gttctttttc aatctttgat tgattttcct 3011461 gaagctcggt taattctttt tccttcgctt caatgctgga agcaacctca gattgcttgc 3011521 tttcgatttt ttgtttcttt tcatctaatg tttccgccga tgcagtttta cttgtaaatg 3011581 ggatcaaaaa actgcttgtc ccgatgacgg aagccaaacc aagtgtaatt aaactctttc 3011641 tcacttttta tatcctccct tttactgtga acctgtcctc atttggaatc gtattttgaa 3011701 catcaagttt cgttcctcat actctacgag gaatgatggt tgtttatggt taattattct 3011761 gtgcatctct tattctggtt gtatagcgtt tatttcacat catatgtaaa aaacactaat 3011821 tccttatgta cgagaatcat tataccatca agtttcgaca aattagcgat aaattttatt 3011881 acatttatgt ttcaaacaga tgtcaagtca cacatcattt gtcatttttc ttaagcgtgt 3011941 aaaaaaactg tcgatattat tttcttaata taatctatct aacaaaaaaa gagtcgatta 3012001 aataaatcaa ctctttaaaa tttactattc tagaatatca tcaatatatt tcatatattt 3012061 cgtcaaagtt gccggagaga tgccgaatcg ggccgctgtg tcttttttcg tgtcttgctt 3012121 gccatgggct tctttccaaa tataacagat ggctgctgcc cagcctttct cattcttcaa 3012181 cggagcagct gcacgaattt gctggatgac atgaaaaacc cagcagctca tgacttctgt 3012241 tttcatctct tctttttcag cttgctctaa tagtttgacc gtttgataag cgaaaagtgc 3012301 atcctctgaa acgtcagcag ccgcagaatc tccattcaga agcagcttta caaaatgagt 3012361 ttcaaaagga gcggtaattc tctttgagcg tatcaccgct tcaagatgct ctgtttctcc 3012421 ctttgtgctg ctgatataat aggctgcgag tcgctgctcc acagatgaag gaagagcttc 3012481 cctccgctca atccaaggcg ccgggcggtc ttcgccggga tattgcgact cgacttttct 3012541 ccagatcgtc tcggcaaagt cggtatgtcc cgtaaaataa gcagagcagg aaagccagta 3012601 aaagaaggtg tcgtcaccct caaagccggt tttatataat gatttgagcc atttatatcc 3012661 gatctcgtag cggccgacaa gcgccaaagt agcacccaat ttataacgct gctccaatag 3012721 catcggatag acattggaga gctgatcact caattccgcc actttttcgt cttctctttc 3012781 ataatagtag aaaacgagaa gattgcataa ggcgtgaaga tttccttcat tatgagaaag 3012841 cacttcataa gcggtttgct tcgcttttac aacgtttcct gaatagaaat aggcaagcgc 3012901 gagattgttg tatgctgacc aaagctccgg atattcagtt gtgatttcct caagcgccgc 3012961 aaccgcttca gcaagctggc cgctttccag caatgacttt gcccgatcct gtttcaccag 3013021 cagttcatcc tgatcataca acgaatcctc aatgccgtcg tctcctaaat cgagcaaatc 3013081 aagcagacta tcgttttctt cggcgaattc accatccggg tccgcatcag aataagcggc 3013141 cgcttcttta taagcttcct ggaagagccc cagatgggca aagttattcg ctttaaagta 3013201 atggcactcc ggcatttcgg cctccagatt tgccatgata tagtcaagaa gatcgttcga 3013261 ctcttgatac tggcccattt ccgaataaat gaccgcaagc tgtgaaagca tctctgaatc 3013321 ctccggctcc aaatgaaccg cgcgctgaat cagtttgctt gcccgtttta gattgcgctc 3013381 tttatacgct ttcaagcctt tatgaaaaaa atattgtcca tcttgaagca gctggacaat 3013441 ttgtgcgtga tttttatgtt cagaagtgtg ttttcccaca actaccctcc gttttataca 3013501 atattaccgt cagtagtata ccataaatcg taagcccctc aatagttcaa aaggaaggat 3013561 tgggaaaatc cctcctcttt tttattggct gattcgacca aaatttaccc ggctttgttt 3013621 tctaagtccg cattcatttt cagctgctgt tcagcaaaat cccggtaaag gccatgggaa 3013681 gccattaact catggtgtgt tccacgaccg gtaatttccc ctttttcaac aaacaaaagc 3013741 tggtccgcat ctacaacggt agataggcgg tgagcgataa caatcgttgt gcggccctcc 3013801 atcagcacct ccagcgcctg ctgaactgat ttttcagatt ggctgtcgag acttgaggta 3013861 gcttcatcga gcataagaat gcttgggtta cggagaagcg ctctcgcaat cgcgattctt 3013921 tgcctttgtc cgcctgacag cataatgccg cgttcgccca cttctgtatc aaactgattc 3013981 ggcagctcct ttataaaatt gagcgcatat gccatctccg cggctttttc gatctcagca 3014041 tccgtcacat ctcgttctaa cccgtagcaa atattttctc tgattgtccc ggacattaac 3014101 gggctttcct gtgatacata cccgatatgc tccctccacg attcaagcga gtaagtatcg 3014161 accggctcgt cccccagccg aatggtccct gcagtcggag aataaaagcg ttcaagcagc 3014221 ttaaacagcg tcgtttttcc cccgccgctc ggaccgacga tcgctgtcac tttccctgct 3014281 tcaatgacgg cgctgacctc ttttaagatc agctgatcag gcttatatcc aaaagacacg 3014341 cgatcaagct ggataggcag atgtgcattt tcaatttgtt ttcctgtcac tgtatcttcc 3014401 tcttcctctg ccaaaatctc aatcattcgt tctgttgcac cgattgattt ttgcagctgt 3014461 gtgaaaaacg ttgtaatctg gcccatcggc ataataattt gaaacaaata taaaataaaa 3014521 gccacgagcg ctccggctgt gagctcgcct gatgagacct gcatgccgcc atatccgatc 3014581 actgcgacaa gcgctgccat taacacgagt gaaataagcg ggccgacaag cgattgaacc 3014641 ttggcttcac gaacgccaag cttaaataat gaggaaatcc ccatcttccc gcgcccatat 3014701 tcgacatcct ccgcatttga agccttaaca agtctgattt ccgggagaat ttgattaagc 3014761 aggcctgtaa aacgagccgt ttcatcttgc gtttcccgtg aaatggagaa cattttccgt 3014821 ccaatcggca ccaaaataag agcggccagc ggaacgacca ctaacacaag cagtgtcagc 3014881 ttccagttca taataaacaa gattgtcaat gatccaatga cagaaatgat gcctgtaata 3014941 aatccgctga tatgggttgt aatcaattct ttgaccacca tcgtatcgtt cgttacacgg 3015001 ctgactgttt ctccggaagc atttgtatcg aaataagaga caggcagctt aattaatttc 3015061 ttccataata actcccgcag cccggaaatg attttttgtc cattatagtt aagcgcatag 3015121 gtggcataag cgcttaaacc cgcctgaacg aaaaacacca gcgcgatcaa accgatttgc 3015181 gtgcctgaca gatttgacat agaaaaacca tcgacaagct gcttcgttaa taatggaatg 3015241 agcaggctga ccagcgtggt tactacactg agggcaagcg caaaggcgag ctttccataa 3015301 gaaggattgg tccgtcttac taaggcaaaa aagggtttca atttactttt agatttttgt 3015361 ttcttggttg gcatatattt tcctcctgtt tcagcgttca gaaaggtgaa aagtcatagc 3015421 aaaaggatga tttttactct ttctcaatca tatcaatgga gaaagacttt ttcagtatat 3015481 ttttgccgtg atcaaaataa aaatctccca ctcattgttt gaataggaga tttttgtgtt 3015541 agacatcttt cactggcttc ttttttctgt aagtcaatgt tacatcctgc tgtcgcaggt 3015601 cttctattat cattttgtac cgatcaactt ttgcggtatg ttcttctttt atcatctgaa 3015661 gggcagcttt tcgtttttcg ctattagact caagctcttt ttttattttt tttacaatca 3015721 accctttttg ccctttgatt tcctctttta atgaagactc aaatttcttt gtcaggctga 3015781 gaaagtcgtt gatcggttga ttgagggtgc ccgctttccc cttcatttca tcttgggtaa 3015841 gaaacatata ggtcgttgat acaatttctg tttcactttc tgaaaataag gaagtcactc 3015901 ttcatattcc tcctaagact gaaaatcaaa taactgagaa atcatttctt ctttttcaaa 3015961 cagcttttca atactctcgc ggatattttt gataaaatct cttttttctg ttgtctgttt 3016021 ttttaattca gcaacaattc catcatttgc aggaagcgca cctgtgtgga atgattcatg 3016081 aactgagatt ttctccaatt tatcgaatgt gtggctgaaa ccagctgcaa gccggaattg 3016141 aagatcgaag gcataatgcg aagggttttc ttccatatga tgaatagccg tgatgatcgc 3016201 ctgctttttg tctatgaagt cttcatcgat ttcctgactg taaaccttct ggtacttaga 3016261 aatcgcatct tccatatctt caacgatttt cataccgttt tgatagattc tgacagcgga 3016321 tgagagattg acttgaatcg tttctcccga gccactcttc cctgtaaaat aaatatcgga 3016381 gcctttatag ctgaagcctt tttcctttga caaggcgttg agcatttgaa cgatgctgtg 3016441 gccgtcgacg ataagtttta gtgcgtcttt tgtttctgtg tcgagtgttt tcaatgagga 3016501 cagaattgat tttacatagt ccactatttc accaacgtct tttaaagctt gcataaattg 3016561 gccatgtttt agatggtcta tgaaatgttc gtaccgtgac tctatgcctc gcatactcgc 3016621 attaatattc gttaattctt ttttgatgac tttcttttgc gtttcatcaa tataaccatt 3016681 ttcagctaac tgatctacga ccggtccgct gtttctcaac aaggtatgaa gaaaacctaa 3016741 aaacgacggc agttcctctt ttattcggcc atacatttgc ttaacatcat caaaatgctc 3016801 atataggaca cttactttct ttaaagcgcc gtctgtgttt ttcacttttt caatcaggtc 3016861 tatgtctatc ccgctggctg cctttataaa accgttcaag ccgtcttttt catagtcatc 3016921 cttatatttt tgaaggaatt tttgaattga cctcacatct tcgtcaggaa ccccatccat 3016981 aatgtttcgg atgcctttta cacttgtatt tgtatctgcc atcttcacat caccgaatgt 3017041 aataaaatcg gccttgccgc tgactccata cagcgggtca tcttttgaga tgcgctgagt 3017101 gatgtttgtt gttacgcctt tgtcttcata atatttttgg atttcttttt ttaacttttc 3017161 tggcgggatg gaatctatat cttcatattt ataactaaat ttcctaataa catatctata 3017221 taaactttca tcagtttcaa gtaattgatc aatattgact tgagctccat ttaccccata 3017281 aacttcatca tattctccat caatcaattg caccataact tggttattat ttgcaagtga 3017341 atgtcctaag gcgaatgttt ttaaatcctc agagttacct gctgctttct ttgctttgtt 3017401 agtaaactcc tttgtagcct catactgact atgatcaatt cctaaaaaaa gaccaaaaaa 3017461 gttatatgac caatccttat tatcggcact accttctgaa ataatctgaa gctgatcaat 3017521 atgttttttc tcatctatta tatggattgc cgttccatcg taacctgatt ctctggtcga 3017581 actttgtata cttgtattct gatttacaag ttcattggag gtgtaaattt caattttcat 3017641 attctcagga agatcgtggt gggtttcctc tttataaatt ctgcgtatat ctgcttcgaa 3017701 atccttctta gctttcttaa cttcactcgc aatagttgag gcaaactttt gtttatagtc 3017761 atattctaaa tcaattaacc ttaactttac gttctcattc tcaaatacat ttttatttcc 3017821 catcttattt ctccttttta tctattaaaa aggtgataga attaattaat ttctcaactt 3017881 tatttttagc cttttcttca tctaaggagc atggttgatt ttcatttttg catccaaggg 3017941 taaaggcgta ttctactcct aggttatctt cctctgtaga cttaacatat ccaaaataac 3018001 tgtatgaata attatatttt ctatcaatat cgtcaaagat gtcttttttc ttggcagtgt 3018061 aaatatccgt tttctttttg ctgctttttt tgtattcgcc tttataatca ttttttccac 3018121 taacaatatc tagcattgtc ttaggttcat tcgcaaaact ttcttctttg taatatgtta 3018181 catggccatc aaacattaca ttggtgtctt tatcataact attaaatcca atactttctt 3018241 tgtttttccc ggttaacgat gatcttcttg atagatactt tccatcctcc ggaaacaaca 3018301 tcctaaaccc tttcagctta gattccagca aataatatcc tggttcctct tcttttgttg 3018361 acaccatgta ctctctcgtt ttctcgtcct gaaacgcagg tacttgaggc agatccttgg 3018421 gatccatgtc ttttggtttt accgcttctg ttttattgtc atttgtgctg tttttatcat 3018481 tgtcattcat actgcatcct cctgtcaggg caagtaataa gctgaagcaa ataaagatga 3018541 tctttttcat tacgaacctc cacgggtttt gtgagaatag tattctattt ttatatcaaa 3018601 aataattcta ttgacctggt taagagatga ttatttcatc ctttttcatg ttacatcatg 3018661 gcggaatttg gataaatagg aaatgagact cggttttgat ctccttttat taactaatca 3018721 tatataacac ccaatataaa tctaaatacc tattactttt ttcacaaaac aaaaagagcc 3018781 gtatcatccg gctctttact cttcaatctc agaatggcgt tttttcaata cgtcaagcac 3018841 atcatccagc ggcagggatt gttctctgag caggacaagc aggtgataca gcaggtctgc 3018901 cgcttcccat ttgagttcct catgatcccg gtttttcgcg gcgatgatga cttcggatgc 3018961 ttcttctccg acttttttca aaatcttatc gacgccttca cggaagaggt acgtggtgta 3019021 agctccttca ggcatttccg cttggcgttc cgcgatcacc cgctccagtt cgttcatgat 3019081 gccgaatcgg tccgcggcct gttcttctgt ttgttccttt gtaaaacagc tgtagctgcc 3019141 agtgtggcat gccgggcctg acggttctac gagtacgagc agcgcgtctt gatcgcagtc 3019201 ataccggata cctttgacgg cttgcgtgtt ccctgaggtt tctcctttat gccataacgc 3019261 ttggcgtgag cggctgtaaa accatgtttc cttcgtttcc agcgtttttt cgtacgattc 3019321 cttgttcata tacgcaagtg tcagcacttc tttgcttgcc gcatcctgca cgatagcagg 3019381 aattaatccg tcctcgttaa aacgcagttc atctgcctgt ttcatctcac attcaccccg 3019441 tactctttca agtatgattt cacttcttta atcgatgttt ctttataatg aaaaattgag 3019501 gcggccagcg cggcgtcggc ttctcctttt gtaaaagcct caagcatatg ctgtgcgttt 3019561 cccgcgcctc ccgaagcgat aacagggacg gggacagctt cggaaacaag ctttgtcagc 3019621 gtgtggtcga aacctttttt ctcaccgtcg gagtccatgc ttgtcagcaa tatttctcct 3019681 gccccgcgtt tgacgccttc ttttgcccac gcggtgacct cccaatctgt tttctttctg 3019741 ccgccgtgcg tgtagacctt atatgtgtca gattctttgt catacttggc atcaatggca 3019801 agtacgatgc attgagaacc gaaaaactcg gctccttctg taatcagctc agggcggaga 3019861 acagctgccg tgttcaccga cactttgtcc gctccggcac gcagtatcgt tttcatatcg 3019921 ctgagctgat tgatgccgcc gccgactgta aacggaatgg caagcttcgc ggcaacctgc 3019981 tccacaacgt caaccatcgt ctttcgtcct tcgtgcgagg cggagatatc aagaaaaaca 3020041 agttcatccg caccttcccg gtcgtacact tcggcgagtt caactgggtc accggcatcc 3020101 ttcaattcga gaaattgaat tcctttgaca acgcgtcctt ctttgacatc aaggcatggg 3020161 ataatccgtt ttgtgatcat ttgcgcttca ccctttcaag cgcctcactc agcgtaaact 3020221 gattggtata cagcgctttt ccgatgatcg ctccagagac gccgtccgcc tcattgcggg 3020281 cgagagcttc gagatccgcg acggagctga ctccgccgga agcgatcacc gatttccccg 3020341 tttccttagc aagctcgacc gtgcttttaa cattggggcc tgacagcatt ccatctgtcg 3020401 cgatgtcagt aaaaataaag acttccgcac cttcattggc tagctctttg cccagttcag 3020461 ttgccttaag ggttgatgtt tcaagccatc cctctgttga aacaaaaccg tttctcgcat 3020521 ccagtccgat tgcaattttc tcgccatatt gtttcagcat ttttttgaca aacggagggt 3020581 tagaaactgc tgagcttccc aggatcaccc gctcgactcc tgctgataaa tattcataga 3020641 cgtcattttc agaacggatc ccaccgccga tttcgacttt caggttcagc ttttgcgcaa 3020701 tctcaatcac atggcggtca ttcactcttt tcccttcttt ggccccgtcg agatcaacga 3020761 gatggatcca ttcggcaccc tctttctcaa ataactcagc catgtcgtac ggtgaatcgc 3020821 catatatcgt ttccttatta taatcccctt gaacaaggcg aacacatttg ccgtttctca 3020881 tatcaattgc cggatataat gtaaaagcac tcattttttc accttctgtt ctgctgccat 3020941 tttcgtaaat tgggttaaaa tagacattcc gaccgtgctg cttttttccg gatgaaattg 3021001 ggcgccgaag acgtttcttt ttccgactac agcaggcact cgtacaccat aatcggcgct 3021061 tgccagaagc gcgttctcct ccatcccgtc aatgtaatag gaatgaacga agtaagcgta 3021121 gccttgttct gttttagtca gcagcggaga ttcattatga aaagaaagac gattccagcc 3021181 catatgcgga accttcagct tgtttccttt ttcatcttct gctttcagcc tgactgcttt 3021241 tccttttaac agcccgagtc ctgaagcggt gccgttttct tcgctttctt caaataaaag 3021301 ctgcatgccg aggcagatcc cgagaagcag ccttccctct gagaccatat cgtgaatcaa 3021361 ttgatcaagc ttcgtgtagc ccaaattgtc catcgcgtct ccaaatgaac cgactcccgg 3021421 caaaatgaaa gcatcagctt ctttcagctc ctccggcttt tcagaaacaa aatacggcac 3021481 gccgacacgt tcaagcgcct ttgagacact gtataaattc cccattccgt aatctatcac 3021541 gccgatcatt tacagcatcc ctttcgttga cggtattcct ttaactcgcg gatcgatcgt 3021601 tgtcgcttca tcaagcgcac gtcccagtgc tttaaaaacg gcttcaatca tgtggtgggt 3021661 atttgttcca taatgaacga tgacgtgcag gttcattcga gcttcgagcg ccagcttcca 3021721 caaaaattca tgtacaagct ccgtatcgaa agttccgact ttagcagccg ggaaatcagc 3021781 gcgcatttct aagtgcggcc ggttgcttaa atcaatcaca acttgagcaa gtgcctcatc 3021841 catcggcaca aacgccgatc cgtagcgttt gattcctttt ttatcgccca acgcttcgag 3021901 cagcgcctgc cctaagcaga tgccgatatc ttcagtcgtg tggtgatcat ctatatcaac 3021961 atcgcctttt gcgttaatgg aaagatcaaa ttggccgtgt ttcgtgaata aatccaacat 3022021 atgtgtcata aacggcacat ctgttttaat atccgcttgt cctccgccgt ctattgtaaa 3022081 tgccagctca atatctgttt cgtttgtttt cctgacgcgt tccgcttttc tcatttagaa 3022141 atcctccgtt ctctcgcttc aattgatctg gcatgggctt ctaacccttc cagtctggca 3022201 aaagccgcga tgctttcggc atgttcttca aaggctgatt gactgtaaga aataatgctc 3022261 gatttctttt gaaaatcagt tacgtttaat ggacttgaaa atctggctgt tccgtttgtc 3022321 ggaagcacat ggttcggtcc ggcaaaataa tcaccgacag gctcagggct gtatctgcct 3022381 aagaaaattg cacccgcatg tttgatactg ccaagcaaag cttccggaga ctgtgttatg 3022441 atttctaaat gctctggcgc gagtgtattg acagtctcaa tcgcttctac cattgtttcc 3022501 gccacatata tacaaccgta atctctcact gaagcttccg ctatttctct tcgcggcaag 3022561 gtttccagct gcttattcac ctcggctgaa accgtctcgg ccagcgccat ggaatctgtg 3022621 acaaacacac atgagctaag cttatcgtgt tccgcctgtg acagcagatc ggctgcaatt 3022681 tcgctcggaa tcgctgtttc atcagccagc acgacgattt cactcggtcc ggcaatcata 3022741 tcgatatcga catcgccgaa cacttctcgt ttggcaagcg cgacataaat gttgcccgga 3022801 cccgtgattt tatccaccgg ctcaatggtt tctgttccgt atgctaacgc cgcaatcgcc 3022861 tgagcgccgc ccattttgta aatgtctttt atgcccagct cggctgcagc aaccaaaact 3022921 ccaggagaca gcagaccgtc ttttcccgga ggcgtgacga gaacgattct ttcaacgccc 3022981 gctacgagcg ccggaatcac attcatcaaa acagatgaag gatatgcggc cgttcccccc 3023041 ggcacatata caccggcgga atccagcgcc gtcactttct gccccagcat tgtgccgtcc 3023101 tttctgtgat aaaaccagga ggattgcagc tgtctttcgt gatattccct aatattttcg 3023161 attgcctgcc taatcacctg aagaagacgt gaatccagtg aggtgtatgc ctcctcaaat 3023221 tcttcttttg tgaccagcgg gctgtctatt tcgatgcagt caaatttcgc cgtgtagctg 3023281 cgaaccgcct gatcaccgtt tgctttaaca tcttcaataa tggaccggac cgtctttctt 3023341 tgctcttccg ttccggcatc gatggaacgc ttgagagaaa gccgttccgc tccgctgatg 3023401 gttttgatct tcattttgcc gtctctcctt ccacaacgag agataggcgg gatgccattt 3023461 cgtcaatcac atcgtctttc atgcgatagc ttaccgggtt gacaataaag cgagaggtaa 3023521 tgtcacaaat gtgctccgtt tcaacaagcc cattttcttt cagcgtctgt cctgtggaaa 3023581 caatgtccac tatccgatct gcaagcccaa tgagcggagc cagttcaatt gaaccgttga 3023641 gcttaataat ctcgacttgt tctccctgct ctctgaaata actggaagcc acattcggat 3023701 actttgtcgc gattcttggc gctactccgc tccagtctgt attcggaagt ccggcgacag 3023761 ctaagtggca tttgctgatg tttaaatcca gtacctcata cacatcgcgt tcctcctcca 3023821 gcatgacatc cttgcccgca attccgacgt ctgccacgcc atgctccaca tacgtggtta 3023881 cgtccatcgg cttcgctaat ataaaccgaa gattttcctc cggcacatcg atgatcagtt 3023941 ttctcgaatc ttcaaactcc tcagggagcc tgtagcctgc ctgcctcagc agccctgccg 3024001 cttcttcaaa tatccggccc tttggcatcg ccattgtgag taacttaccc attttgctct 3024061 tcctttctgg caccgataaa ataagtgacg tttgcaaaag attttgtcat ctggtcgata 3024121 ttttctattc ccgataaatc ttgaagaacc actttgttcc ctttcatgcg ttcttcattc 3024181 gcataagcga tggcttgcgc ccgctgctct ttgctgaaaa taacagcgtc tatttcacaa 3024241 ggttcgtcct tcatatgaag ggcttcaatc agccggtcga tccgaagccc gaagcctgtt 3024301 gccggtgcag gtgaatcaaa atggcccagc agcttgttgt aacggccgcc gcttccaatg 3024361 acaaaaccga cattctcggc gtacacttca aataaaatcc ctgtgtaata gctcatgtgg 3024421 ctgaccatat tcagatccag gcggacattt tccgtacatc cgtaatcctc aagaatgtcc 3024481 cacagcgcct tcagctcatc aaccacgctt tttccttgcg cagaatcgac gatttcctcg 3024541 gcacgtccgc atacttctat accgccccgc agttcaagga gctcaagcag cctgctttta 3024601 tcaatggagg aaagcgggag agacttgaca tgctctctgt agccgacgta gttcttttca 3024661 tataagaacc tccgcagcac atcagctcgt tcaacgtttc cgagcacctc aacaaacaaa 3024721 gcatccgcaa tgccggcatg gccaattgca attttaaagg atgccagccc agcgtttttt 3024781 aatgccccga cgactaaagc aatgacctcc gcatccgcgc tcgtcgtgcc gtcaccgatt 3024841 aactccactc cgacctgctc gaactcagcc ggacgtccgc cttcacgctc ctgagccctg 3024901 aatacatttg ccgcatagcc gactcttagc ggatgaccgt gtttcagaag cttcgatgcc 3024961 gccacccttg caatcggccc cgtcatatcc gggcgaagca ccaatgtctt gccgtcctga 3025021 tcaagtagct taaacagctg ctgctcttca attgctgact ggacgccaac ggtatcgtaa 3025081 aactccagtg tcggcgtttc cataaattga tatccccatt tatcaatcaa atcggttaac 3025141 gatcgtctca cctttttttt cgtttcgtat aaaccgggca gtgtatctct catgccgtgc 3025201 ggtttttcaa acataaacat caacccgagc acctccgctg ttatcttatg aaggaaaatt 3025261 ccgaatcctt tagttcgcta atatgataat atgttagcag atgaaagaat gaaaatcaac 3025321 gcttaacttc agtaaggata tttttagttc aaatatcctt ctcctcatta tgaaaaaatc 3025381 atgaataatg tattaaaggt acgtaatatc tcaaattctt tatgtttggc atgctataat 3025441 acaaatcaaa tagagaacaa ggagataaag atgaaaacac tgcgaactct atgtgtcctg 3025501 atgattcttt caggcgttat ttttttcgga cttaaaatag atgcaaaaga tatagatatt 3025561 ccttttttga acagccttaa aaaagtggtt tctgatagcg atacagactc agctgcgaat 3025621 agcaaaaagg agctgaaggg aagcgcaaaa ccgctggatg tcatccttta caatcaaatg 3025681 gacgcacccc ggctctataa cggctgtgaa gtaacaagcc ttgcgatggt gctgaattat 3025741 gcgggatacg acgtgacaaa aaataccctg gcaaatcagg ttgccacagt gcctttgaca 3025801 tacagcagcg gattaaaggg tgatccgaat gacggatttg tcggggatat ggcgaatggc 3025861 cctggtctcg gtgtctacca tcgaccgatc tatcagctgg cgaaaaccta tgcgggagac 3025921 aaagtgtctg atctgactgg aaaaagtatt tccgctgttt atcagcagct tgaaaaaggc 3025981 aatccagttt gggttattac gacagccaac tttacgccag ttgacaacat gcagacatgg 3026041 aaaacgccaa acggaacgat agaaattacg tacagcgaac acagcgtcgc cgttacggga 3026101 tatgatgata aatatgtgta tctcaatgat ccgtatggct ataaaaacag aaaaaccgat 3026161 agaacaagct ttgaaaaagc gtggaaacaa atgggcagcc aggccgtggt tattcaaaag 3026221 taaacacctg aagcctcact atgctctatt ctgagcaaat acgacaatat tcatgctttt 3026281 tgtatcaatc ggtaagatcg attcattttc catttttcac ccaaaattgt ctttactttc 3026341 aggctgtctg tttttatgat taaagcagat tcagccttgc cccgatctat gcgagagaag 3026401 ccggtgcaag tcgctgacgc ttctcttgca aaaaatgaaa gatatccggg gaggatttat 3026461 cattgaaaaa aatcgtgtct atcctattta tgttcggttt ggttatgggt ttcagccagt 3026521 ttcagccatc aaccgttttt gcagctgaca aagtggtgca cgaaacaatt atcgtaccaa 3026581 aaaatacaac atatgacggg aaaggacagc ggtttgtggc agggaaagaa ttaggtgacg 3026641 gaagccagtc agaaaaccaa gaccctgttt ttcgtgtgga ggatggagca accctgaaaa 3026701 atgtggtgct tggtgcacct gcagctgatg gcgtgcacac ttatggaaac gttaacattc 3026761 agaatgtgaa atgggaagat gttggtgagg atgcgttaac ggtgaagaag gaaggaaaag 3026821 tgacgatcga cggcggttct gctcaaaaag cgtcagataa gatattccaa atcaataaag 3026881 ccagtacctt cacagtgaaa aatttcacgg cggataatgg cgggaagttc attagacagc 3026941 ttggtggttc aaccttccac gttgatgtga tcatcgacaa gtgcaccatc acaaacatga 3027001 aggaagcgat attccggacg gacagcaaaa caagcacggt cagaatgaca aatacacgct 3027061 actctaatgt cggtcaaaaa tggattggtg ttcagcatat ttacgaaaac aacaacactc 3027121 aattttaaca aaaaaagtcc gctgatgtta ttcagcggac tttttcaatc tttcttgcat 3027181 ttcttccttc gtatagatga tcctcatcgg atttccgccg acaaatgccc cgtcaggcac 3027241 atccttatgg acaagcgttc cggcggacac aactgcgcca tctcctattt tcaccccggg 3027301 cagaatggtc gtgttggcac caatcatcac ttcgtccccg atcagaactt tgccgatccg 3027361 gtattcgtga atcaaatact catgggccag aatggtcgta ttgtacccga tgattgtatt 3027421 tgttccgact gagatctttt ccggaaacat gatatctggc atcaccatga gggcaaagga 3027481 tgtctgtttt ccaaccttca tccgcagaaa tgtgcggtac agccagtttt tcatccctat 3027541 aaacggcgta tatctcgcaa tttgaatgac aatgaaattt ttgacgacct ttaaaaaagg 3027601 taccgtttga tagacatgcc acagtgagtt ggcccccgag accggatgac gatctgtttt 3027661 tctcacagat tacttcactc caacgatttg taatagatca ctcattttct caagcataaa 3027721 atccggctca tgcttcgcca gcatttccgg ccctttaatc gtccatgcga ctcctgccgt 3027781 ttttgtaccg gcgtttttcc ctgccagcac atcatggtaa ttatcaccga ccataatggc 3027841 ttccgccggc tcgcttccta gctgtttcag cgctaacagc acaggctcgg gatcaggctt 3027901 tgcattcgtc acatcatcaa gggtgacaac tgtttcaaag aattcgccga ttcccgtgag 3027961 cttgaggccc atattgacag tatctcttaa ttttgttgtc acaattccta atgtaaagcc 3028021 ggcttttttt aatgcatcca gggtctcata taccgtttca tattcagtga cgagtgaatc 3028081 atgcatgtca tgattgtacg ctctgtacat agcgatcata tcctcgcatt tatcagggtc 3028141 catcgaagag aacgtatcaa aaagagacgg cccgataaat gcaaggacat cttctcgttt 3028201 atacttgctc ggataataat gctccagtgt atgcaaaaag gacgcgataa ttaattcatt 3028261 cgtattaata agcgttccgt ctaaatcaaa cagaatcgtc gttacttgtt tgtcactcat 3028321 attgcttcct ttccaaccgc tgagggtttc cattttttcc acgtgtgcgc aatagccatt 3028381 gtcagcagaa ctgctgtggt gacacgaatc aaaagaagcg gccagaccgg tatgccaagc 3028441 ggaataaaga caagtgtatc ttccacgacc gcgtggcagg caacgagaaa tataaatgcc 3028501 aatgtcatgt cccgcttgct cacgccgtca tcctcgacag ctttgatcat gacacccgct 3028561 ccgtaggcca gaccaatcgt cagtcccgtc accatcgtca tagacgtatt tttattcatg 3028621 ccaagcagct gcgtaaacgg cgacagccac ctggaaaacc gataaagcca gcctaaatct 3028681 cttaaaaact ggatgataat catcagcggg atcactattg ccgccagctg caaaacacca 3028741 agtccggctt tcgttaatgc ttctgccaac attcctagcc agctgtctgg cgccgcgctc 3028801 ttcgcagcga taaaaccgta ctgcgccgtt tcctttccgc catgccaaat gaggttgatg 3028861 acgatggctg acacagcggc caaaccgatg cgcacggcca atatgacgcc aattctgata 3028921 ccaacctttg cggcaactgt cgattcgata atcaagttat gacagaaaga aagcataaca 3028981 gctaaaataa agacttcttt cacagataaa tccaatgtta aaatcccggc aattcccgca 3029041 tacagattca gcatatttcc cagtacaagc ggaatggccg cttcaccaga aagcccgaag 3029101 agacccatta ccggtgtgat cagccgtaca agccaatcca tgacaggggt atgctggagc 3029161 aaagtgacca atagcgttac cgggaaaatc actttaccca gcgtccatgt tgtttgaaaa 3029221 cctgctgcaa gaccggccag aaagatcttc ttcatccctc atcccccttt gttgacgtct 3029281 actccgcgta ccgctccttc gagtatccct tgacgcgtct gaagatgatg gctgccacag 3029341 ccaaaacaat caatacgatt gaaatcacct gagcgatgcg aagtgaatca gtcagcatta 3029401 agctgtcagt ccgcattcct tcaataaagt atcttccgat tgaataccaa atgatataga 3029461 tcaagaacat ctcgcctcta cgcaaattcg ctctgcgcag cagcagtaaa acaatgacgc 3029521 cgacaaagct ccatagtgat tcatataaaa aagtaggatg ataatattgc ccattgatat 3029581 acatttgatt gatgataaat tcaggcaggt gcaggttttc taaaaaggct ctgctgacag 3029641 cctcgccgtg cgcttcctga ttcatgaagt tcccccagcg gccgatcgcc tggccgagca 3029701 aaatgctggg cgcggcaata tccgcaagct tccagaacga aaggtttttc actctcgaaa 3029761 acacataacc cgttaaaatg gcgccgatta atccgccatg aatggcaatg ccgcccttcc 3029821 aaatcttaat gatttctccc ggatgtgccg cataatagtc ccattcaaag gcaacataat 3029881 aaattcgtgc gcaaataatc gcaattggaa tggcaaacag gacaagatca ataaacgtat 3029941 ctttctgcag cccccgtttt tcactttccc tcatcgctat ccacagcccg agcaaagcgc 3030001 cgagaccgat aatgattccg taccagtgga cggctaacgg ccccagctga aatgctatcg 3030061 gattgagtgg ttctatcgct tcattcattt aacgccaact cctattcttc ttgttcaccg 3030121 tcttcaatga cgtccgccag cttgttggta aattgttcag cggcattcag ccccatccgc 3030181 ttcaatctga agttcattgc tgccacttcg atgatgactg caagatttcg gcctgggcgg 3030241 acgggaatcg tcagttttgt aatttctgta tcaatgattt tcatggtctc ttcctcaagt 3030301 ccgagccggt cgtattgctt gccctgctcc cagagttcaa gattcatgac aatcgtgatt 3030361 cgtttattgc ttctgaccgc gccagcgcca aatagcgtca tcacattgat aatgccaagg 3030421 cccctgatct caagaaggtg ctcaattaat tccggagcgt ttcccacaag agtatcctga 3030481 tcctcctgcc gtatttcaac gcaatcatcg gcaacaaggc gatgccctct tttcacaagc 3030541 tctagcgctg tttcgctttt tccgacgccg ctttttcctg tgatcagcac gccgacacca 3030601 tatatatcga caagaacgcc atgaattgct gtggtaggcg ccagcctgct ctcaaggaag 3030661 ttggttaaac ggcttgacag tcttgtcgtt ttcagcggcg atctgaggac aggcacccca 3030721 tttttctcgg aggcgtcaat cagctcctgc gggatgggca tatctctaga aagaataata 3030781 gctggtgtta catcagtgca cagagaatcc attcgctgct ttttctcctc ttcaggaagc 3030841 tgttcaaaga aagaaagctc tgtttttccg agaagctgca cgcgctccct cgggtaatat 3030901 gtaaaatatc cggcaatttc aatacctggt cttgataggt cactcattgt aatcgggcgg 3030961 ttaattcctt cttctccgct gattaattcc aaattgaact gttccattac gtcttttgtg 3031021 cgaacctttg ccacgatatg ttcctcctgt tccgggctgc cccgagcttg ctcacaatac 3031081 tttcatttta tcactttcgg gcttgaacct aaaacagatt ttataaaagg ggggaaaaca 3031141 cctcagctgg tctagatcac tagtctgaaa aagagtaaaa taaaggtatt caaattccag 3031201 aaaggcggat catctatggc agagagtctt cttatcaaag acattgcgat cgtgacagaa 3031261 aatgaagtaa tcaaaaacgg ctatgtcgga atcaatgacg gaaaaatcag cacagtttca 3031321 acagaacggc ccaaggagcc atattcaaaa gagattcaag cacctgcgga ttccgttttg 3031381 cttcccggca tgattgacat tcatatccac ggcggctatg gcgcagatac aatggatgct 3031441 agcttttcca cgctcgacat catgtcgtca agactgcccg aagaaggcac gacgagcttt 3031501 ttagccacaa cgattaccca agagcatggg aacatttctc aagctttggt gaacgcaaga 3031561 gagtggaaag cggctgaaga gtcctcttta ttaggtgcag aactgctcgg cattcattta 3031621 gagggcccct ttgtttcgcc taaaagagcc ggagcgcagc caaaggagtg gattaggcct 3031681 tcggatgttg agcttttcaa aaagtggcag caggaggcgg gcggactgat caaaattgtt 3031741 acacttgcgc cggaggagga tcagcatttt gaactgatcc gccatttgaa agacgaatcg 3031801 attatcgcat ccatggggca cacggatgcc gattccgcat tgctgtcgga tgccgcaaaa 3031861 gcaggggcga gccatatgac tcatctgtac aacgcgatga gcccgtttca tcaccgagag 3031921 cccggagtga tcggaacggc gctggcccat gatgggtttg tgacagagct tatcgccgat 3031981 ggcattcact cccatccttt agctgcaaag cttgcttttt tggcgaaagg cagcagcaag 3032041 ctcattttaa ttaccgattc catgagggca aaaggactga aagacggcgt atatgagttc 3032101 ggcggccaaa gtgtgacggt aagaggacga acagcacttc tttcagacgg aacccttgcc 3032161 ggttcgatcc tcaaaatgaa cgaaggcgca cggcatatgc gtgagtttac aaattgctct 3032221 tggacggata tagctaatat aacttctgaa aacgcggcca aacagctggg catctttgac 3032281 cgaaaaggca gtgtgactgt gggaaaagat gcagatttgg tgattgtcag cagtgattgc 3032341 gaggtgattc tcaccatttg ccgcggaaac attgcattta tatccaagga ggctgaccag 3032401 atatgaaagt aatggaatgt caaacgtatg aagagctaag ccaaatagca gccagaataa 3032461 cggcagatac aatcaaagaa aaacctgatg ctgttctcgg tttagcgacg ggcggcacac 3032521 cggaaggcac gtatcgccag ctgatccgcc tgcaccaaac tgagaatctc tcatttcaaa 3032581 acatcactac agttaatttg gatgagtacg ccggactttc aagcgatgac ccgaacagct 3032641 atcacttcta tatgaacgac cgtttttttc agcatatcga cagcaagcct agccggcatt 3032701 ttattccgaa tggaaatgca gacgatttgg aggccgaatg cagacggtat gaacagctag 3032761 tcgattccct cggcgacact gacattcagc ttctcggcat cggccgaaac ggacacatcg 3032821 gctttaacga accgggaacg tctttcaagt cgcgaactca tgttgtgaca ttaaatgagc 3032881 aaacccgcca agcgaatgcc agatattttc cctccataga cagcgtgccg aaaaaagcac 3032941 tgacaatggg aattcaaacg atactctcaa gcaagcgcat tctgctgctt atttctggaa 3033001 aaagcaaagc ggaagctgtt cgtaagctgt tagaaggaaa cataagcgaa gattttcccg 3033061 catctgcttt gcacctgcat tccgatgtta cggttttgat tgatcgtgaa gccgcgtcat 3033121 taagaccttg aaaggaacat gctgacttat gaatatcaat aaacaatcgc ctattccgat 3033181 ttactatcag attatggagc aattaaaaac ccaaattaag aacggagagc tgcagccgga 3033241 tatgcctctt ccttctgagc gcgaatatgc cgaacaattc gggatcagcc ggatgacagt 3033301 tcgccaggcg ctttctaatt tagttaatga aggcttgctc tatcgcctga aagggcgggg 3033361 cacctttgtc agcaagccaa aaatggaaca agcacttcaa gggctgacaa gctttaccga 3033421 ggatatgaaa agccgcggga tgacaccggg cagcaggctc attgattatc agcttattga 3033481 ttcaactgag gagctcgcgg ctatattagg ctgcgggcac ccctcctcta tccataaaat 3033541 cactcgggtg cggctggcaa atgatattcc gatggcgatt gagtcctcac atattccgtt 3033601 tgagcttgcg ggtgaattga acgaatcgca ttttcagtcg tcgatctatg atcatattga 3033661 aaggtacaac agcataccga tttcccgtgc aaaacaggag cttgagccaa gcgctgccac 3033721 cacggaagaa gcgaatattc ttggtattca aaagggagcg cctgtcctat taattaaacg 3033781 aacaacatat ctgcagaacg gaactgcttt tgagcatgca aaatccgtat acagaggcga 3033841 ccgttataca tttgtccact atatggatcg tctttcataa aaaaagcctc caaccctttt 3033901 taaggattgg agacatggcg aaaatcaaac tggtctggtg ccggacgata tgtttctttt 3033961 ttcgtcttga acttccagat cggtgatttc gttttgccgt taaaactgtc ttccactata 3034021 atgtaccaat aataaacaga ctgcggttca agatgatccc agcggaattc agctgtgtcc 3034081 ccgctcttca cttgctcccg ttttccgagc tcttcattgg tatatacgtt acattcaaaa 3034141 taatcggttt ccaccttttt gattcttggc ttcaaatcaa gcgaaaggga aaattcatcc 3034201 ttgttgccat aggtatccgt atcatagtag ttcttatcct ttacatacgg agagtacgtc 3034261 gatacgtgca ccatgtcatt ggcttggtca aattgaagca aacgcaaata cccttggccg 3034321 ccttctggcc cgccctgata atcggccagc atttgatgca caagacgatc cggtttccca 3034381 tcaccatcat catccagctc atctgttttt ctcatcgcac tatgataatg cccgctcaac 3034441 accatcacga cattcgggtt cggctttacg atttctttga atattttctc tccgattggg 3034501 cttctgtttc cgctgaccag caaatactca tgaaaagcta aaatggccat ccggtcagga 3034561 tgcttcttca gcacctgatt catccacgcg atgtcttcat ccgtaatgcc ccatcccatg 3034621 tacagcatga tataatcatt gccgttgcta gaaatcaggt cataatgtcc gcggttattt 3034681 ttataggaac cgccataatg aaatttttta tcaaaacgat cgctgccaaa atatttgcca 3034741 aacgccctgt aggagccgtc cttatgtccg acatcgtgat tgccggccag cacgccgtaa 3034801 ggaattccgc tcttatccag aacggacatt gaccgatcag cgtttttcca ctgtctgata 3034861 tcggcggaat catctacaat atcacccgtg tggaacacat atttgatatt gagctgcttt 3034921 tgattatctt ttatccattc ggtctgttta tcaaaaatat gcggatagct ttcggcgtaa 3034981 tactgtgtat cagacatcca gacaaatgtg tacatatcct tcgcaggagg aatttcatcc 3035041 tgtacaatca cattcatttt cgactcccgt acaaaatcgg cggcaatcac agacgctttc 3035101 agcgtaaacg gtttgtcatc cttcgcgacg aagctgtcaa caggctgcca ttcgtttgtc 3035161 cgataattcc aagcatacat cgtcaccttt ctccccggca aagaactgcc cttccagact 3035221 gattctgcca gatcattctc atcaattgat ggatcaaccg tcacttcaaa gcgatgataa 3035281 gggaaaagct ctttgttttc tgtcgatact gtttttccat cagcagctga tacccgctcc 3035341 aattctttat tcgtaaatgg ggtctccctt tccggcacaa agcttttcgg cggttcagtc 3035401 agtgacgcgt gcttaaatat tttcacatga ttgcgcgctg tatattgaaa tcccctataa 3035461 aaaccaacat ccatggcatc attcgtcgga tctttcaccc gtacagaaag cttggcctta 3035521 tgcgtgtcgg cttcgctgtc tataacctcc ggctggtccg gatgctctcg ttcggtttta 3035581 aatatcctct caatcactgt tttattgccc gcgagatccg ttgctgtcac ttttagagaa 3035641 tgttttcccg gcaaaaggtc agaagatgac gtatgatatg ggagtgtaat gctttctcca 3035701 tctaacgacg cctccgcttc ctcaattctg ctccatttat catacatatc cgcctgcagg 3035761 ataaggtttc ctttatacgt ttgcccctcg gtgatattcg gctcaatgtg aggtcctgaa 3035821 ttatctaccc gtacaaccag gctgacattt tccttcccgt cgcttgcttg aatatggtga 3035881 gcgccttcag aaagctttga tgtatcccac tccagcagct gtgatgtaaa tagtccgtca 3035941 ggcagattga actgaaattg ccagctttta ttcgagcgct gattatcgcc aataaagagt 3036001 tccttctcag gagacaccct ctgatctctg atcaccgttc catccgataa caccaatcgg 3036061 gcgtttttga ctaagaagtc atcacggttt tcagccgtat caaacggaga caccttcgaa 3036121 cctgaacgta tcgtaatacg ctgcagctgc ttccctttcc gaagcagtgt ctctggcaat 3036181 ggaacagaat aggtgcggta tttatttgtt gtatcatcga acaccttcag cactttgcct 3036241 tccatcgtta ccgcgttttt aaaataaagg ttcgttttcc tcgtatcgaa tgcaaaatat 3036301 acttcttttt ccatcgcggg ctctgtcact tgttttttcc cgtcaatcca tagcttaatg 3036361 ctgtcagctc gcccttctgt cgtggctttg agaaattgag ttcccgacag cgtgtctctg 3036421 ttttcaatat tcatccgcag accgtgcgcc ttgcttgttt gtttaatatc aatcattttg 3036481 accggcgttc tcgcttcatt gatcccgtcc ccggccgcca cataatactc tagctgatcc 3036541 ttcccgatca attcaggcga atacacaata taatggaaga gattatcgtt gcggtctttt 3036601 tcagcaagaa ttcgcttaaa cggtttgttc tcatccgtcc ggtagtaaaa ggccactgtt 3036661 ttcactaggc ttcggtcccg tatgtcagcc cgcagctcaa tgctttcagc agggcggaca 3036721 ggcttgcggt cagtcaaatc ctcaatgacc ggcttttctt tatcgagctt gattttccgt 3036781 ttctggtcgg gcacctgtgc ctgtaatacg gttccgggag acggattctt ttccccgatt 3036841 gaaatgttca gaagttctgc tgttccgttc agtggatact tataaagcac tgatgacagc 3036901 cggcgcagcg catgtttccg ataatgcgca accgaaatgt cctttcctgt attcgttgat 3036961 atcacaacgg cccgcggcct cgtattggcc ataccctctg tctcgtctat caccgcaaga 3037021 ttttttcctt cttttagttg tgtctgataa taacgattga aatccgctga cgtcaattct 3037081 ggatgcccgg caggcttcag ccagacgaca aacgtttcgc cggatggtat caagatcctt 3037141 tcatcaggtc tccaaatcag atcggagtca ggcccttctt ttgggtagcg gtaacggata 3037201 tggtagtctt taaaatcaat cgttctgtca gtcgtattaa aaatctcaat aaattcataa 3037261 ccgtctgcgc gtcctatatt cttcgtatca accgccagct ctgtgatcag aagctccgga 3037321 atatgggcaa ggtcagcctg gtatccttca agcttcagtt tcttcgtctc cgactcaacc 3037381 cgctgcttcc cattcgacat cacaatgtaa tactcaagct cgctgttcca aatcaaacgt 3037441 ttcggaattt gtgccaaaaa cttgcggacc gctccggggg tcgggtccat cggcaccatt 3037501 ttgtagccca gctcattact ttgtttataa aaaagaaagg cggaaaatgc ttgatacgaa 3037561 ttatcgcgaa cttgagcctc aatcattaga ttgcttctca tttcagcttt cacatcaatt 3037621 tgaggaggat tttcaagcaa gggtatgtaa tgaggcgttt gaaatagttc ctgctgtaca 3037681 acaggaaaag ctttcgattc atgatggccg ccagacaaaa cggaaagaaa agacagtaat 3037741 atagaagcaa taaccgtgta tttcctcatc aaagcacctc ccttttcatg tattttgcgt 3037801 ctgaacaggg aagcttatga gttcattttt gtgcataaag aacaaaaaaa cgtctgtctc 3037861 ttgaaaattc cactattacc cagtaaacta aggatagtta accagttaac aattaaatca 3037921 gagaggcaaa ttgatggaca acagcattca tgatgaatta tttcaagcta tacaacaatt 3037981 cgcattaaaa agggataaac gcgtctggca aaaggtgcag ataccatcca ttggcatatc 3038041 ctcacaacat cacgatcacc tcaaaaaaga ctggactttg acccagcttc acattgtttc 3038101 ctgcatacat accagccaaa atgtgaacaa cagcttctta gcatcccgtt tacacatctc 3038161 aaaagccgct gtttcaaaag cggttcatgc tttgttgaaa cacaatatca ttacagtgac 3038221 aaaaaagcct ggcaacaaaa aagaaatttt ttatacgcta actgatagcg gcagaaaatt 3038281 ggcggcatta catgaacagc ttcatgagaa agcaaaggag caatataaac agcttttcaa 3038341 tgaattttca attgatgatt taaaaacagt gactgcgttt ttcaacttgt ggatcaaata 3038401 tatgtaaaaa gagtctcacc cgcatgggag agacctttgg aattctatta tgccccgtca 3038461 aacgcaacga gaagtgaaac aggtccgcgt gtatacagac cggactcagc ataacaaaaa 3038521 tcttcctcta atctgatatt ccgcatctta tccagcacaa tattagctac aatttcgatt 3038581 tcgtttttgg caaaagctgc tcctacacag ttatgaatgc cggatccgaa agcgagatgc 3038641 cgggcggcgc cgctaaaagc gctcttgata ccaagatctt cccgatgaat attaaacacg 3038701 tcaggctgtt caaatgcttc agggtcccgg ttagccgcac cgatcataca aaaaacaatc 3038761 gtatcttttt tgatttccat accgccgacc actgtatctt gggacagctg ccgcggaatc 3038821 agctgaaccg gcggtttata acgcaatgtc tccgcaatgg ctctcggaac taacgaacgg 3038881 tcagccaaaa catcattcat ctgctcagga ttgttgagca aatggtagat catcagtgcc 3038941 agcgtcttat cagccggttc cgttgcggct aacagcacat taagaatcag tgcgagtata 3039001 tccttgtccg acagcgccat gccttcatat tcagaagtac ataggatcga aattaaatct 3039061 gatcccggat tgacgcgacg ttctttaatg accggcatca agtattggga aagctgttcg 3039121 ctgcaccata acgaatgtgc ccgcgcttca ggagattgag agatactcgt gataaaatcg 3039181 gcaactccgc tgtgccactc agagattttt tcatggtctc ttttatccag cccgagcatg 3039241 tccatcgtga cgcacaccgc aaacgtcttt ccaaaatcat tgacgagatc acttttccct 3039301 ctttcaagat aaggcgctaa caagttttct gcattttgtt taatcaatgg agacagatga 3039361 tccagtgcgt caccgataaa gcttctcact acaattcttc ttttggcaga gtgttctttt 3039421 ccatgcattt gggccagcac agggcctcgc atgactggtt cggcacgctc aacaagtgat 3039481 ttcgtcgtga agatatccgg atgctgaagg atatagcgga catcatgata gcggctgata 3039541 aaataactgt ctatcgactc ttcataatga accggatctt cctcccgcag ttgtgaaaaa 3039601 taagcatatg gattgttttg aaattgatca gaaagcacac taaacaattt aatcgattgg 3039661 ctcatgtttt actcccccta tcatccttca gatgtgatcc gtttctcaga aagcatctgc 3039721 gccatttcct gtacaatgag atacccttga ttcggccgca tacaaataga aaattcatgg 3039781 ttactgatct tctcacccag cttccacgga cgatgataag caaggagtgt ctcttccacc 3039841 tctaaaatat ccggagctcc gataaaaaac ggcagctcag ctatgacata ttccacagcc 3039901 aaattcagca tatcctcact gacttcttcc atcatcaaac tgacgccccg cgcacgcccg 3039961 attatcgctt cacgagacat gtccaaacaa gcatgtcgaa aatgaggctg ctcaaaaaat 3040021 gcatgttcaa cttcttgtct caacagctgg taggctttgt tatctataaa atcagaaaat 3040081 gtatgaatcg ccttcggatc cccgccatga gccacaaggg ctctttctgc aaatctcctg 3040141 tttcgtgata cctctttcct tacttttcgt tcagcctttc ctctcggagt tccaagcgct 3040201 tctagaagat tagccgcctc atgccctgca agtaaaactg aaacgctttt aaattgagct 3040261 ttcgcccatc caattaatct gtaaatataa tcctctgaaa acctgctgtt aaatgggctg 3040321 atccccacca aaacatgcct gcgccgttca aatatttctc tgcagttttc tgttaatgcc 3040381 tcagcaataa aatgcacaga ccttctttcc gttaccattc cggtcatctc attcacccct 3040441 aaaacttatc ccgctttaag tcatcaccct caaatacaag atggaatagc tagaacaact 3040501 gaacaagacg aatggcaggc atcacttaaa gtttccaaat gttttttaag attttaataa 3040561 tcattttcaa tacccatatc atgataaatg tttactagta aacattagtc attttatccc 3040621 ttttccttcc aaacgtcaat atgatctgtg cccaaatatt tgaaaataaa tgtaaacatc 3040681 acattttcca cacacttttt acacgcatat tcagcatgac atatcaacaa atagtctaaa 3040741 caccaacaat tgacaacgaa aacaagaaaa gataaaataa aattgttcac cagtaaacga 3040801 tttgttttat tgtttcatcg taaactatta ttcctaagaa agaaggtagc ctatgtctga 3040861 tttgacaaaa cagatgatat acgacatata cgtgagactg ctgcacctta atgaacaaaa 3040921 agcgaacact tcacttcagc aattttttaa ggaggccgca gaagaggatg tagctgaaat 3040981 tcccaaaaat atgacaagca ttcacgtcat tgactgcatc ggccagcatg aacccattaa 3041041 taatgccgga attgccagaa aaatgaactt atcgaaagcg aatgtaacga aaatcagcac 3041101 aaaactgatc aaggaagaat tcattaacag ctatcagctg acagataaca aaaaagaagt 3041161 ttattttaaa ttaacccgta aaggcagacg gattttcgac ttacatgaga aactgcataa 3041221 aaaaaaggag ctggcttttt accaattcct cgattcattt tcacaagaag aacaaaaggc 3041281 tgtattgaag tttctagagc agttgacgtc aacacttgaa gcagaacaaa ccgatgggac 3041341 tccagacaaa cctgtaaagt aaacaaaaag gcggtgtaca ctttggctca tacaaaatca 3041401 aaggcagtat tgatcttata cactgtttgc ttcagtgcat tttttgcatc tttaagccag 3041461 aacatttatt cacctattct tccgatcatt aaagaatcat tccatgtttc cacagctatg 3041521 gtgaacctgt cagtctcagt ttttatgatt gtgacagcaa taatgcaaat tatattagga 3041581 gcgatcattg attttaaagg cgctcggatc gtcttgatta ccggtattct ggcaacggca 3041641 gcagccagca tcggctgtgc ggtgactact gactttacct tgtttctgat attcagaatg 3041701 atacaggcag ccggttccgc agcactgcct cttattgctg ccacaacgat cggacagctg 3041761 tttacaggaa atgaacgcgg gagtgcaatg ggaacgtatc aaatgctcct gtctgtcgca 3041821 ccggctattg ctccagttct aggaggattc ataggcggag cagccggata cgaagggatt 3041881 ttttggatac ttgcggccat ctctatcgtt ttgctggtga caaacagcat cacctttcct 3041941 aaagattctc caactgaatc tatgcagcaa gccaaaggca atgtgttcgc tcattataaa 3042001 tcaatattta caaatcgaac agggaacgtc attttgactt taagttttgt tctctttttc 3042061 atttattttg cagtaattgt ctacctccca atattgctga cagagcatta ccatatagat 3042121 gtgggtatag caggactgtt atatttgccg ctggcgctga gcacgattgc aggtacgttt 3042181 ctgtttaaaa gaatacaggc aaaaatcggg ctgcacacct tgtttatcgg aagcaatgtg 3042241 attgccgcct gcagcatcat tttatttgct gttacacatt ccgtttctct cgttctcatg 3042301 gctctgacgc tggcactgtt tggcatctcg atgggggtta ttcctccctt gtactctaca 3042361 atgattacta atgaatttga gcacaacaga gggagtgcaa tcggaatgtt taactttatc 3042421 cgatatacag gcatggcagc aggtccgatg gtatctgcct acttgctcac aatgatgccg 3042481 tctgccatgt cctttagcct cctaggcctt ggatttgccg cattgagctt ttgccttctt 3042541 ccgccaatgt tttcgccgca gaagcgcacg aaacaaaaaa agcaccacat gtaaaaaagc 3042601 tgcctttgcg ggcagctttt tttatttttt tctaagcggc tctaaaatgc ctttttgaat 3042661 cagcaaatgg aagaccgaca ggataacgga tgcccatatc gctgtgccga agccgtcgat 3042721 ttgaaagctg tcacccataa tggacgcggt catcataagc gtgatggcgt taatcacaaa 3042781 caagaagagt ccaagcgtca ccatggtgac cggcagtgta aatataatta aaagcggttt 3042841 aatcagcacg tttaagatcg ataaaatgag gctggcgata atcgctgccc caatgctgct 3042901 gatatggatg gagtcaatat atccatcaat gacgattaat aacaatgcat tgactaaaat 3042961 gctgactgcc cattttacca tgtcatttca tatccctttc tgacgggacg ataaaaatcc 3043021 aaatgatata aatgagcaaa accggcaaga cacttgtcat aatggctaag atgacagtta 3043081 tgactctgag gagtgatgcg tcccaattga aatattccgc gagacctccg ataacaccgg 3043141 cgattttctt atttttttct gagcgataaa gcttattcat tcgatcacct ctgtgagtac 3043201 tttagtttga tggcgcctgt tagtgattct gagaagacgg tgatgttttg atcatgtgcc 3043261 tgatttgaag tgaacatcat ttctttttga atcgtatcat ttttttcctt cagcatctct 3043321 acatccatta attcatggga cagcgtacca agattgcttt tcagctctgc cttcactgcg 3043381 agatcgtccg gaattgcaag ctctacattt ccagtcgttg tttttgcata aatggagcgg 3043441 cagtctgatt ctgttacgtt aatcgcaata tttccgttaa agctttgaac gtcaatggat 3043501 tcgcttttcc ctcggagatc gatcaatccg ttaatggttt ccgcttctat cgtaccgcag 3043561 ctgtggcttg cgagcttaat ttgcccgttg gccgtttcag ctatggcttt ttcggctgtt 3043621 aaatacgaga acgacagcac gccgtttgtc gttttcgctg agaactcttt tacatgtaaa 3043681 tgttcccctc tgactggacc gttaaacagc ttcacccgaa tcttatcata ctccttctga 3043741 ggaatataca aagtgacatt cgttttcatc gtctttttct cagtacggat aaaaaactta 3043801 ttacctttga tttcacattc aatatgctga agaaatgcgt gtctcgccgc atcctggctg 3043861 tcagcgcgat ataccttcgc ctggcattcc gctctgatat cgtcatcttc ccaagggacg 3043921 atatttacgc tgccattggc aatttgcagc tcaacactgg aaaagtcagt atctttaaat 3043981 tgaaaaatgt gctgaacatc atacgcatgg ccaaagttta aatcaaggtc aacttccttg 3044041 acctttttca cagcagaatc aatccagtca aacagcttgg ctcctaaaga cggtttgccg 3044101 ctttcttttt ttgccgttgt aaatggctct tcctcgtcat gaacgtgaac tgagagcgct 3044161 gtgattttct cttctttttc cttgtagtcg ctgtcaagct tttcaatcag tgtcaaagct 3044221 tcttgtgctg taagctttcc ttcctcaaca agcttaagga ttcgttcctt ttcttgcttc 3044281 attacgatct cctccccatt gtctacttat gctgcacgca ggaccttaat gccctgaatc 3044341 acattccaaa tgataatgcc aatgacaact aagaaataaa taaccgctcc cccgatgatt 3044401 acaaatacag gaagcaagct gtctccatca atcgcaacgg ctccgccaag taaagcaata 3044461 aaaaggaaca gccagccgac aaacggaaca atgtgagaaa taagagagcg tatcgcatgg 3044521 cgttttgttt ctttctcatt tacaacaaaa tatgcgacaa tcggcacaat gattggcgca 3044581 atgaacacac tgaaataaca aagtgatgca ataatagctt gattacggtt caattcattc 3044641 cacactccta ttgtgaattg tccatgacaa aagatcaggg acgttttact tatttatacg 3044701 tttaaaatct cttcaggttt caaattcatt ctttagacat gctccgattt acggaaattg 3044761 gattttaaaa agttttagaa gtagaatctt ccggctatac cgattacaat atgtaaaaag 3044821 cttacggcaa ccaaggaggc tggacaagca atggagaaag atcccagtga ctatacagta 3044881 acacaagaat cagtgttaaa gctgattcag gaacaaaaaa gaatgaatcg tgaaatgatc 3044941 accgagcttg agcagattca cggacccttc ccgatctctc acgatatcca atatataaaa 3045001 gtgctgctcg acagcagcaa cacacatatt gttcaagatt taatgagtgt aagtaagcag 3045061 ctgtataaga agactttgta attgcggaaa acatatcatt cattataact gaaacaaagc 3045121 taaaggttag atgacaatat cttgcctttt ttgttttgaa aaaacaagtg attccctggc 3045181 tgtcacaaaa tgattgtaac aaaaaaagcc tgccggcaca tccagttaat ggactctgtc 3045241 ggcaagctgt aactatcaga aagagatagc cgttcaaaat taacgtaaca attgaagcac 3045301 gttttgcggc tgttggtttg cttgagcaag catcgcttga gaagcttgag aaggaatgtt 3045361 gttctttgtg aactcgctca tttctttcgc catgtcaacg tcacggatac gggactcagc 3045421 agctgtcagg ttttcagaag aagcaccaag gttgttgatt gtgtgctcta gacggttttg 3045481 taccgcacca agtttagcac gttggtttga gacattgttg attgcagtat caatactttc 3045541 aagttgtgta tcaaaaggag tattagcaaa atctgttaca ttaagtgcgt ttactcctaa 3045601 agcagttgat gacatgctgt caatgttaac tgtaagctgc tggccagcat ttgctccaat 3045661 ttggaaagtg aaaccatcag tttcagtacc atctaataac tttttgccgt tgaattcagt 3045721 acgatttgaa atgccatcaa cttcctcaat aagcgcatcc atttcatctt taattgcacc 3045781 aagatcttct gcttgttgtg tacctgtgtt tcctgcttga acagtaagtt cacttctaaa 3045841 cctattatgc cgtaaagaaa aagcttgcct gctaagccca aggatggact tgccgacaag 3045901 ctgtcccctc ttaacagagg gttttaagat gtagctgttt cttttgcttt caagagcgat 3045961 ttcatgcgtg ttttgtcacg ttcgataaca ggctttaaat aacggcctgt atacgattct 3046021 tcaacttcag tgatttcctc aggcgttcca gacgcgacaa tggttccgcc tccggctccg 3046081 ccttccgggc ccaaatccac aatgtaatcg gccgtcttaa tgatatcaag attgtgctca 3046141 ataaccagta cagtgtctcc gttgtctacc aaccgttgca gcacgacaag aagcctggcg 3046201 atatcgtcga catgcaaacc tgtcgtcggc tcatctaaaa tgtagagcgt acgtccggtt 3046261 gagcgtttgt gcagctctga cgcgagcttc acgcgctgcg cttctccgcc tgacaaggtc 3046321 gtcgccggct ggccgagcgt aatataacct aaaccaacat cataaagggt ttggagcttg 3046381 cgtttgattt tcgggatatt ttcaaagaaa gaaagagcat cttcaaccgt catatcaagc 3046441 acatcagaga tgctttttcc tttgtacgtc acttcaagcg tttcacggtt atagcgtttg 3046501 ccgtgacaca cctcgcatgg aacgtatacg tcaggaagga agtgcatttc aattttaata 3046561 atcccgtctc cgcggcaggc ttcacatcgt ccgcccttca cgttgaagct gaaacggcct 3046621 tttttatagc cgcggacctt cgcttcattt gtctgcgcga atacatcacg aatgtcatca 3046681 aatacaccgg tgtatgtcgc agggttggat ctcggcgttc ttccgattgg cgcctggtca 3046741 atgtcaatga ctttatctaa atgatccaaa cctttaatct ctttatggct gccgggcttc 3046801 gctttcgctt tatgaagctt ttgcgccagc gccttatgca aaatttcatt aacgagtgta 3046861 ctctttcctg aaccggaaac acctgtaact gctgtaaacg tcccaagcgg gaacttggca 3046921 ttcacttttt tcaggttgtt ttctgatgca cctttaattt caatgtaacg tccgtccggc 3046981 tttcttcttt caggaggcaa tgggataaac tttttccctg ataaatagct gcccgttaat 3047041 gaatttggat cttccatcac ttcttccggc gtacccgcag atatcacctg tccgccgtga 3047101 atgccggctc ccggtccaat atctattaaa taatctgctg ccatcatcgt gtcctcatca 3047161 tgttcgacaa caatcagcgt gttcccgagg tctctcatat ttttcagagc gctgatcaag 3047221 cggtcgttat cacgctgatg cagaccgata gacggctcat ctaaaatata aagcacaccg 3047281 gataaacgcg agccaatttg agtcgccagc ctgatgcgct gcgcctctcc tccggacaat 3047341 gtacccgctg ccctgctcaa tgtcaggtaa tcgaggccga ctttgtccag aaagcttaag 3047401 cgctccacaa tttcgcgcaa aatcaaattg gcgatctgca tatccttctc agaaagggta 3047461 agatctttaa agaaggcaag tgcgtcggcg acagacagct cggtaatttt cccaatgtgg 3047521 cggccgtcaa tcagtacggc aagcgcctct ttctttaacc gatagccttt gcacgtcgga 3047581 caagacttct gagacatata ctgctccatt tgctcacgta tgaaatcgga gcctgtctcc 3047641 ttatagcgtc tttcaatgtt gcgcaatacg ccttcaaatt gaatttcacc ttcgcggatt 3047701 tgtccaaaat cattttcata tcggaaataa atcaggtcat ccccgctgcc gtacagcact 3047761 ttatccagtt gatgcttcgg caaatctttg accggcacat ccatatcaat cccgtagtgg 3047821 gtgcagactg cctcaagcag ctgaggataa tattgtgagc tgatcggtgt ccaaggggcg 3047881 accgcattct ccttcaatga caaatcttga ttggggatga caagatcggc atccacttca 3047941 agcttcattc cgagaccgtc acacgtcgga cacgccccga acggactgtt aaacgaaaac 3048001 agacgcggct caagctcacc aattgaaaat ccgcagtgcg gacaggcatg atgctcgctg 3048061 aacatcagct cttcctcacc gatgacatcg atcataaccc gtccttcacc taaacgaagc 3048121 gccgtttcca atgaatctga cagccgggct gccacgcctt ctttcacgac aatccggtca 3048181 atgactacct caatggaatg cttcttgttc ttttctaatt cgatatcgtc ggaaagctca 3048241 gccatctcgc cgtcaattct gactctgaca tagccttgtt tcctaatctg ttcaagcact 3048301 ttgacatgag cgccttttcg gcccgagaca atcggcgcca gcacctgaag cttcgtccgt 3048361 tccgggtatt ccagaattct gtccaccatt tgctcgatgg tctgggatgt aatctcaatt 3048421 ccgtgttccg gacaatgagg cttccctact ctcgcatata aaagacgcag ataatcataa 3048481 atctcagtta ccgtaccgac agtagacctc ggattgcggc tcgttgtttt ctgatcaatg 3048541 ctgatggcgg gagagagccc ctcaattgca tccacatccg gcttatccat ttgccctaaa 3048601 aactggcggg cataggcaga cagcgactcg acataccgtc tctgtccttc agcatatatc 3048661 gtgtcaaagg caagggagga tttacctgat ccggacaaac ccgtgacaac gacaagctga 3048721 tctctcggaa tcgttacatc tatatttttc aggttatgcg ccctggctcc cttcacctct 3048781 atccgatcca tagccatttg ttcatcatcc ttccgctttt agctctaaaa gtaaatcgcg 3048841 aagctccgcg gctctctcaa agtcaagcgc cttggcggct tccttcattt catgctccat 3048901 ctgttcaacg actttctggc gttctttctt cgtcattttc gacagcttcg gcgcggcttt 3048961 tgttttgtat tccgctttat cctcagctgc tactgtggca cgaatgacat cgcgaatttc 3049021 tttatttatc gttttcggcg taatgccgtg ctcttcgtta aaccgctcct gctgctcgcg 3049081 gcggcgtttt gtttcattaa tcgcaatttc catagacttc gttattttat cggcgtacat 3049141 aatgacgcgg ccttccgcat ttctcgctgc ccgtccgatg gtctggatca gcgaccgctc 3049201 cgaacgaagg aaaccttcct tatccgcatc caaaatcgca acaagggata cttcgggaat 3049261 gtccaaacct tccctcagca ggttgatgcc gacaagcaca tcgtacttgc caaggcgcag 3049321 gtcgcggata atttcaatcc gttcaagcgt cttgatctca gaatgcagat agtttacttt 3049381 aatgccgatt tcctttaaat aatcggtcag atcctctgac atcttcttcg tcaaagttgt 3049441 cacaagcacc cgttcattcc gctcgattct tgcttgaatt tcgccgatca agtcgtcaat 3049501 ctgaccttcg attggacgga cgtcaataag cgggtcaaga agccccgtcg gacgaatgat 3049561 ctgttcgacc atttcatctg tatgttcaat ctcgtacggc cctggtgttg ctgatacata 3049621 cacgatattg tgcatatgct tttcaaattc ctcaaaacga agcggacggt tatcaagcgc 3049681 tgatggaagc cggaagccgt gatccacgag cacctgtttc cgcgcctggt ctccgttaaa 3049741 catgccgcgc acctgaggaa ttgtcacatg cgactcatcc accacgatca taaaatcgtc 3049801 tgggaaataa tcaagaagcg tatacggcgt tgaacctgga ggccgcagag tcaaatgtct 3049861 tgaatagttc tcgatgccgg agcagaaacc catttcacgc atcatttcaa gatcatatct 3049921 tgtccgctgc tctaaacgct gcgcttcaag gagctttccg ttttcatgca tgaccttcag 3049981 ctgctcctca agctccttct cgatattttg aatcgccttc tccattttct cggcccgcgt 3050041 tacgaagtgg gatgccggga aaatcgcaac atgatctcgg tcgccgagaa tttctcctgt 3050101 cagcgcatct acttcccgaa tccgttcgat ttcgtcaccg aaaaattcaa ctctgacaca 3050161 atgctcatca cgggatgccg gaaagatttc cactacatcc ccgcgcacac gaaatgtacc 3050221 gcgctgaaag tcgatatcgt tgcgggcata ttggatgtct acaagttttc tgagcagctc 3050281 gttgcgctca atttccattt cagtccgcag tgacacgacc atttcccggt attcctcagg 3050341 cgaaccgagg ccgtatatac aagacacact cgcaataata atgacatctc tgcgctcaaa 3050401 caaagctgat gtggcggagt gtctcagttt atcaatttca tcattaatac tagcgtcttt 3050461 ctctataaat gtatccgttt gaggcacata cgcctccggc tgataataat catagtagct 3050521 gacaaaatac tcgacagcat tgttcggaaa aaattccttg aactcactgt aaagctgtcc 3050581 agcaagggtt ttgttatggg caatcacgag agtcggctta ttgacttctt taatcaaatt 3050641 ggacaccgta aatgttttcc cagttcctgt tgcacccagc agagtctgat gcttcttgcc 3050701 ctcctgaatt cctttcacaa gcttttcaat ggctttcggc tgatctccct ggggctgata 3050761 tttcgagact aactcaaagc gatctttcac aaaaataagc ctccgtttct ttaacgaaat 3050821 cttcctatag atatagtaac acaatggaaa gcaaaatcac taaaaatacg aactaaagtt 3050881 cggtggtttt ttatttccag ctgtttttgt gtataaaaaa cctgctttta aaacgtaaaa 3050941 gcaggtattc agtctttata ttcattatgt ccgatttatt cttctttttt ctctgcagct 3051001 tttttggcca tatacagtcc gccagccaca agagacacaa catccaatcc tacaataaaa 3051061 tacgtttctg tatagccttt taaataagag gcaaacagca atgcagctgt taaagcgatc 3051121 gccacataat gattaaaggt gactctagta aatagaacaa caagcataaa agggaaaaac 3051181 aatgcaaaaa cggcttttgt aatcaacaaa aaccctcctc agggattctt catctgatct 3051241 gattatagta aaaaatgaag aatcggacaa tcgtgcattc gctccctcta cttacaccat 3051301 accccttttc agccaaaatc aatcaccata tttgcatttt ggtgccggtc aaaacttatt 3051361 ccatggtgcc gctgttctaa tcagcggcac tttttttatt acatcatcaa gtccgccgcc 3051421 agattccgag aataaaagaa aataggcata cagtaccagt acggccgcat ttttcaggat 3051481 aatataacca acttaactat tcattttatt taggactttc tgcgtttgac agcattttcc 3051541 tgaaaaccta caattaaatg atagtgttta ctatcatttt ttaaacacag gctccgcaat 3051601 aaaaagacta gagagaaaaa caaaatgaat gaagaaaaga ggggtttcaa atatgtattc 3051661 tgttttattt cgccaggcag aagagtccag ccagctggct ggagcaaaag gaatgaattt 3051721 gattaaattg accaaacacg gtcttcctgt tccggacggg tttattattc aaacgaatgc 3051781 gctcgcacgt tttatggagg acaaccagct tcaagagact agtgaaaacg tcgaaggcgg 3051841 gatcatttcc ggaacatttt cggatgagct gaaagatgag ctgactagtt ccttttataa 3051901 gcttagagaa tcatatcgat ccgtagccgt gcgttcttcg tctgcttcgg aagatttaga 3051961 aggcgcctca ttcgcgggtc aatatgaaac ctacttaaat atcaaaacag aggaagagtt 3052021 tctggctaaa gtgaaagaat gctgggcctc atttttttct gggcgggtca gcagctataa 3052081 gaaaaaaatg aacaatcaaa tcgcagagcc gttaatggga atagtcgttc aggggctgat 3052141 cgattcagaa atgtcaggtg ttatcttcag ccgcaaccct gttacccatg atgatagaga 3052201 gcttttaatc agcgccagct acgggttggg tgaagctgtt gtttcaggaa atgttacccc 3052261 agacacgttc attgttaata aatcttcgtt tgagattcag aaagaaatag gtgcaaagga 3052321 aatctacatg gagtctgcgg cagaaggaat tgctgaaaaa gaaacgagtg aagacatgcg 3052381 cagccgtttt tgccttacag atgaacaagt gattgaattg gctgaaatca caaaaaaaac 3052441 cgaagacctg tacggatatc ctgttgatat agaatttgga attgctgatc atcaaatata 3052501 ccttctgcaa gctcgcccga ttacaaccat tgatcaggac aaaaaagcgg cagaagaaaa 3052561 acgcagcttc atgattaccg acactgatat gaatgatttc tggcttaaca tggagtctaa 3052621 tattgaaggt ccggtgagtc cgttattttc atccttcatc gtgccggcat tggaatatgg 3052681 cttgaagaag agcatgcaaa agtttccgat tggtgtagtt gttgatgaag taaaacttta 3052741 tcgcggacat atttattcca aaaaccaagg cggacagcag cctccttctg aagactgcgg 3052801 caaagagctt ttcccgattt tatcggagca tatgtatgac atcatcaatc acacatacct 3052861 ccctttttac cggacactgg accagctcgc acaaactgag cataccgcag aaagcgcact 3052921 ggaagctttt caaaaactaa aggcctttta tctcacggct tatgaagagc actttaatat 3052981 cgttttcccg caaatccttt taacaaacaa actgcaagcg atgtatcagg acattcaagg 3053041 agagtccgaa aacgctcatt tttacgagat gctgacagga aaaatgaaca aatcactgga 3053101 aacggaccgt tgcttatggc tattttctgt ggaagttcag gagaacccga accttctggc 3053161 catttttgaa aacaacaagc ctgaacagct ccaggagaaa ttggaacaaa cagatgaggg 3053221 aagacacttc ctgaagaacg tccatgaatt cttgcaagaa tacggatgga gatctgttaa 3053281 aagtcatgat ctgattgaac aaatctgggt ggaaaatccg tatttcgctc tggccaatat 3053341 tcaaaattat gtccgtaatg gctatcattt tgacaatgaa tttcagaaaa caaaagaaaa 3053401 acgagagaaa ttatacaatg aattcttgga aagcatagaa gatcccggtt tacgcaccga 3053461 atttgaccgc tattatcaat ggacactgaa ctctgcaaat ataaaagatg atcaccactt 3053521 ttatattgac gccatgctgg atgccaaggc gagaatcttt ctgctgaaga taggtgaatt 3053581 gctggcggaa aacggtgtca ttcaagatcg ggaggacctt tggttcttat atgacgacga 3053641 agtggaacaa gcgcttcttc accctgtatc cctgcaagaa aaggctgaaa aacgcagaca 3053701 gatttttcat gagtatgagc tggcccaagc cccggcctac ctcggcaccc cgacaaaaga 3053761 acagctcaaa gcagctgaag aaattgtcgg cgctgtgata gaggatgaaa aaaacacaga 3053821 gaatcatatt tttggcattg cggcatcaag cggcattgcg acaggtccgg tgaaaatcat 3053881 tcgggacgcc aatgaatttt ctcaattcgc gcctggagac gtactcgttt gcaagatgac 3053941 cacaccgcta tggaccagcc tgtttcaaga cgccaaagcg attattacag acacaggcgg 3054001 cattttgtct cacgctgcga ttattgcccg tgaatacggc attccagccg ttctcggcac 3054061 acgcacggca accgaaagac tgcgagacgg tgacatcatc actgttgacg gaagcagcgg 3054121 caaaatcaca gttgtcagcc ggtcctgatg cgtccccctc tttcttatac aagcggggcg 3054181 ggtgtatact tgtcctgcca gtatattcgt gaggtgaaac gtattgagac cgacaaacaa 3054241 gagaatcctt gatgctgcca tgcagctgct cgtcaaaaaa ggatatcgcg caacgactac 3054301 aaaagaaatt gcagaaaaag caaatgtaag tgaagcgacg attttcagga actttaaaaa 3054361 caaacaagga ctagttgagg ctttgctttc tcagcattct tcaaacagag gcagcatttt 3054421 ggaacaaaca gaaggggatt tgtacaaaga cctgcttcat atcggaacct gtctcttgga 3054481 ggagctcgaa catagaaaag atatcattaa aatcagcttt cgtgaaccgg ccatgtttca 3054541 ggatgtcatt aaccacgtca ctgaatatcc ccaatctatg aaacagctat tggttgatta 3054601 tctcaaaacg atgggtgaga aaggggttat tcagacagga aatgaagcgg aacatgccga 3054661 cgtgttcatg tcgattatct tcggttattt cattcaccgt ctccacttag gagaccgggt 3054721 catatcaatg ccccaggaaa aaatgctgga gcatagcaca gctctatttg tcaaaggaat 3054781 ttctgctgat taactccttg gcataataaa aaggaggatc ccaatgagct caagaaaaga 3054841 atgggcgctg atcgtctcgc tattattggg ggccattctg gttcccatta actcaacgat 3054901 gatcgcggtc gcgctctcat ctatttccca tacgtataac gagtccatcg caagcatcac 3054961 ttgggtggtt accgtttatt taatcgtgat ggcagtcaca cagccgattg caggaaagct 3055021 cggtgacatg tacggcaata aaacaatgta cttatgggga gtcggccttt ttctaatcgc 3055081 atctctaggc tgcgcccttt caccgagtct gctcctgtta attgtctttc gggcattgca 3055141 ggctgtcggc ggggcattgc ttacgccaaa cagcattgcc attatccggc atgttgtttc 3055201 tgaaaaacgc ctaccgaaag tgtttggatt tttcggactg ggcgcgggac ttggtgcagc 3055261 actcgggcct tttatcggct ctatactgat tgacagcttc agctggcatt cgattttttg 3055321 ggtcaacatc ccgttcctcg ccattgcttt atttacggca ttaacgatgt ttcctcaata 3055381 taaagaaaat aaatctgacg cgccgctgga tatcatcggc tctctcttgc ttgcaggcag 3055441 catcgtttcc attatcctgc tgacgaaaaa tgaggctcca tggggatata ctgtatacag 3055501 tgtattgata cttctttttg ttccgctttt tttcagaaga gaaaaacgta cccagcaccc 3055561 catcattgac tttgcactgt ttaaaagctc aacctttaca aatgcgaatc tatcagtctt 3055621 gttaagcaat ttgatgatgt atgccgtctt attgattatg ccgttattta tgacgaacca 3055681 atttgggctt aatacatcta acagcgggat ggcgctttct gtattttcga tcttcatgtc 3055741 agccagcaac tgggtgggcg cgcagctcca tcacaaatgg ggagccaaaa aaatcatttt 3055801 tctttcattt gccatgatgg ctggtgcgaa tctattattt ttgctgttaa gcagctcgca 3055861 ttctgtcttg ttcctcatgc tctctcttat ccttggcggg ctcgcttccg gagtcggtct 3055921 gaccagcatg caggtttcat cccttgccac agtagacccc ggtatgtcag gagtggcatc 3055981 tgggattttc tcgaccttcc gttatttcgg aagcatcatt tcatcagcct taattggcct 3056041 gatttcggga tatcacaccc tatttatgat tctctttgct gtatccatca tcggcgtttt 3056101 tgtttcattg ggcatcaaat ctgatgaaac ggcacggata gaaaaaaact cagcgtaaca 3056161 caaaacagcc cggcatcgca tcatcctgcg gtgccgggct gccttttatg atcccgaagc 3056221 gactgcttcg tcttcacggt catcctttac gaagaggatg cccaattcat gatgttctcc 3056281 ttcataagaa gctcgctggt caaaacgaat ttctccattc aaaccgataa tttcaagctt 3056341 tacatatgca cggttatgct gaagcgcttc atagaaatca gaaacgttct taaccggtat 3056401 gccattgact ttcgttatga tttccccgat tttcaattcc agatcctcag ccggcgtatt 3056461 ggggataatc ccaagcacca ttaagccctg atcccttttc gagaaataaa acggagccgc 3056521 gttatcattc actctttgct ttatggacag aaaaatacgc cctaacaaag cggtacagac 3056581 cgctgcaccc gcaagcggcg tccacagtaa gctcgctgca ccgagaactg cgacggcaag 3056641 accgagaata caaacgcgtt tcgctgtgat ccttatactc gtttcaggca gcgatccctg 3056701 taccctttgt ccaaatccga caaagtaagg aatccataga aaatggaatg agccgccggg 3056761 aaccgtaaac acgggccacc agctaaggtg cgattctaaa ccattaccgg gcacgagaag 3056821 gaacagcggc aaaagccaaa cccggtttgc cagctgctgt ccgatcggca aaccgcggct 3056881 gcttacgaca agtgccggtg atgttctcac atgcgcagaa cgataagcaa ccgctccttc 3056941 agtgataatc agcaaaccta gaaacacagc cacagccggc caaacaactg caaatccttg 3057001 cggaaatctc tccagaaagg gctccgcctg atatatttgc agtccaaaac ctatcagcat 3057061 actcacactg acgatatatg cagcagacat ccagtttgcg cgaagagtga acgctgccgc 3057121 tgcagtgata acggcaataa tcgcaagtaa accgagagga atcgatattc cgagtccacc 3057181 taaaataact gacaaaagaa gacctggaat cagtcccttt gtatatgtaa atttcagatc 3057241 atcataaata tctgctattc ttgtatgaaa ggtttttcgt tcccgtttga ttcttacata 3057301 gccgaaagcc aaggttatga tgataaaaaa ccagaaaagc gggtgtaaga agaacaagcc 3057361 cgcgcttttt aacagttcaa ttccccattg aacagacact atctctcacc gcctcaagcc 3057421 aaacatgtta ctcatattct atcaaatatt aaatggcttg gatatcctca ggagagttta 3057481 tctctcttgc gtcatccaca gcgtgacatt cgatagtgaa aaatccttta aatagtggtt 3057541 tacatccaca tccaataacc cgctgattag atgcatcgac ctttttatat ctgtcagatt 3057601 aattcctaat cgcttatggt ttttcattaa gtagttaaaa taatgtttgg cgcattcctc 3057661 attaatgtca tttactgatt cgacattggt gtaattgacc aaatatctgc tgaacagcat 3057721 aagaagactt agtgcttttg tagctgaaaa tgttacgtct tgtgttctgt cttttaattg 3057781 ttccactaat tcataatatt tttttttcac gcacaatact tgccctcttc aattgtgaac 3057841 ccccattttc tttatacaga taagcacggg ccagtataag cagcagtact ggagtgctaa 3057901 caagcattct cgctaacgtt actctttaaa tacctgtcgt tcagctgcca ttaacctgat 3057961 tactgttctt tttagaacct tcttatattg tatgaagtaa acaaagacta ggcaacttgc 3058021 aaaagtttca ttttaaatgc atattaactc gttagaaagt ctctctcata tattgatatc 3058081 gggtaataac agtcctttat aaatgtttat ttgtgaaaat ttttttaatt tcttgtcaaa 3058141 aactcatttt ttatgtgact tatgatccat aatctcttta agcacaaaga aacaggagat 3058201 gaaataccat ctcctttaat tgacaaataa tgatttcaat gctgtttgaa gctgcaaatc 3058261 atttttttca tctgattttt tcttttctat ctgctgattt aatgtctctg cagtgcgagt 3058321 gtcgatcaca ccggttttat tcagcttgtt ttgatcctga aaagccataa ccgctttttt 3058381 catgtctttg ctgaaatagc catcctcacg tcccggatca aagctgagac cttttaacaa 3058441 tacctgcgca tgcttgacgt cttcattgtt catgtccact ttaagcggct ctttcagctg 3058501 taagggcccg gcggaaaaat aatcgggctg cttaatcgca atggtcggtt caattccttt 3058561 cttatgaatc cagtttccat ttggcgtcag ccacttgtaa agcgttaatt tgatgttgct 3058621 gccgtccccc attggcacag cctgttgaac cgttcccttt ccaaaagacg tatcgcctac 3058681 aacatcataa tggccagctt cctttaatgc gccggcaaga atttctgatg cagaggcact 3058741 tcctttatcc gtaatcacat tgacagggta cgctttttta tgggtcaatg ttgaaaaata 3058801 acgtttttta tctccattgc gttcagcaat ctgaatatac ggctgatcct ttgtaacgaa 3058861 atgcttaaga atttcttcca cactttgaag atatccaccc gggttgccgc gtacatcaat 3058921 gacaagtcct tctatttctt ttttctcaag ctccctcagc gcttttgcaa aatcctctgc 3058981 ggtgtgctca gaaaaagtag agatggcaat atatccgaca gaatgcccct gtactttttt 3059041 ctctgatgca aaaaccgttt cgagcggaat ctcagctctc ttgatccgga atgacaactg 3059101 cttcttcgtt ccaggccgct gaatcttcat tgaaacgctg gacccttttt ttcctcttat 3059161 ttttaacaca gcgtggttta aatccttgcc ggccatcgat tctccattga tgctgataat 3059221 ttcatcatta ggcttcaacc cggctttttc cgctggcgat ttcttgaatg gagaaacaat 3059281 aataattttg ccgtcttcca ttccaacctc agccccgatg ccttcaaatg aggaatcaag 3059341 agaatcagaa aattgcttag ctgtctgctt gtccatgtaa acagaataag gatcatttag 3059401 cgtagacagc attccctgga tggctccctc gagcagcttt tctctatcta ctttttctac 3059461 gtactcattc gaaattaact catacgcttt ttcgattttg tccatagctt tatcccgttc 3059521 agagtcagct tgtgccgtcg cgggaactgc tgcagtctgg ggcttatcca tctcaagcag 3059581 gttgattccc gcatatacac cggcgcctcc gaacagcatg ctccctgctg ctatcacagc 3059641 cattattttt tgattcatcc tttactcctc ctgtatgcca gactgtcttt accaaaacct 3059701 agagatagta tatgtaaagg atggagattt catgtaatca tagaagaaaa agaaggcaaa 3059761 tgaaaagccg tcccgaaaac ggaacggctt tttcacttta tactcgcaga aacttgcgga 3059821 tggaagtcag acttccccat actccaatta ctgcgccgat tgcaatcagc actagcgaaa 3059881 cttggaatac aaatggatta taaggaagaa gagagacaaa tgatccttga acctttggaa 3059941 cgacccatcc gatgacgtat tggtaagtgc tcagcaccag tgcaatcgga atcacagaac 3060001 cgaatacgcc tagcagcaat ccttcaagga aaaacggcca gcggataaac cagtttgtcg 3060061 cgccgacaag cttcatgatt tcaatttctt ttcttcttgc gaaaattgta attttaatgg 3060121 tgttggaaat taagaacatc gccgtaaata ccaggccgat aattaacgcg attccgatgt 3060181 tgcgggaaac gccgaccact ttaaacaaac ggctgacctc ttcttttcca taagtgactt 3060241 tataaacatg atccattttt tcgatctttt tcgccacgtt cggcgtatca tgcggatctg 3060301 tcgttttgac gacaaacgca tcattaagcg ggttttcctg atccttcatt gtcagggatt 3060361 ttccgctgtc accaaaactg tcaaccagct ggtcaagctc tttttcttta gatgaaaaag 3060421 tgacactctg aatgcccttc agttccttaa tatcgttctg aagcttgtcc tgtgccttct 3060481 gatctgcagt cagatcaatc agcactttga tttcgacttg tttttctgca ttcgtggcca 3060541 tgttattcaa attcagcata atcactaaaa acacgccgac taaaatcagc gtaacggtta 3060601 cagcactaat ggatgcaaat gtcatccatg tgtttctccc gagagattta aaactctcac 3060661 gcaagtggcg cccgagaatt ttaatcatat gaaccatact cccctcttga ctcatcacgc 3060721 acaatgatac catcttcgat tgcaatgaca cgtttcttca tggtgtttac gatttcttta 3060781 ttatgtgtcg ccatcacgac tgttgtcccg cggttgttaa tttcctccag cgtcttcatg 3060841 acttcccagg acgtatccgg atcaaggttt cctgtcggtt catcagcaat gacaacatca 3060901 gggttgttca caattgatct ggcaatagat acacgctgct gctccccgcc tgaaagctgg 3060961 tcaggaaatt gtcgcgcttt atgcttcagc tgcacgagat caagcacttc aagcacccgt 3061021 ttcttaatga cagacggctg ttctccaatc acttcaaggg caaatgccac attttcaaaa 3061081 acagtaagtt tcggaagaag cttgaaatcc tgaaagacaa cacctatttt gcggcgcacg 3061141 aaaggaatct ctttttcttt aattgtcgcg agatctttat gattgattaa aatttgtcct 3061201 tttgtcggtt tttcttctct gtaaatcatt ttaataaaag tagatttacc tgctccgctc 3061261 ggaccaacaa catacacaaa ctcgccggga tgaatggtaa cagaaatccc attgagtgct 3061321 tttacgccgt tcggataggc tttatatact tccttcatct ctatcatgaa atcacctaat 3061381 cttttatatc attttatcta tcacacggtc atactcttcg aatgcattcg acaatttatg 3061441 acccattcat ttgtaaaaag atgaaaaatc tgaaagttcc ctttttcaat acacttcatt 3061501 atacgtcaaa tttagacata atactattac agtttctttt cattcatatt gtcaaggcat 3061561 aaaaacatcc ttgccagcac tcggcaagga tgtttttatc ttactttttt tctgacagcc 3061621 atttggcaat aacagcggct tcgttatcat ctacaagccc ctttggcata ttgccgcggc 3061681 cgtttttaat aatgctttca attttgtgtt catcgtattt gcctccgacc tcttggagat 3061741 taggccctga cacaccttct aaatccttgc cgtggcagcc tacgcagctt tgctgatata 3061801 attcttcccc ttcagatgca gtggcttccg tcttgctgcc agtgtctgtc ttctcttctt 3061861 ttgcatcgtt tgatccgcag gcagccaaca gaacagaaag cgcaaatcca atcattagta 3061921 tcgataactt tgatttcatg ttgagaagca caactccttt acgatctctt ccatattata 3061981 acctcgttta agcgcgtttg aaaccctcgc ccagcacctc gctcgcgtct gctacaatta 3062041 caaaagctga ctcatcaatc tgtttgacga tttgtttcaa tttggtgaat tcagtttgcc 3062101 caaccacgca cattaaaatc ggacggtcat cgtcagtata tccgccgact gcagaaattt 3062161 ttgtcacgcc tctgtcaatc ttctgtaaga cagcctcctt gacagcctgc tcctgctttg 3062221 taatgatgag cgccattttt gaacgattaa agccgacttg cacaacatca atggttttgc 3062281 tggacacata gacgccaagc atggcatata agccttgctc aatattaaat acaatcatag 3062341 ccgtaacaac gatcattccg tcaatgatgg cgagacactt ccccaatgac agaccggagt 3062401 acttatgaat gatctgtgca gccaaggctg tacctcccgt cgaacctttc cctaagtaca 3062461 caataccaat tccgatacct atcccgacac cgccaaaaat cgccgccagg agttcatgat 3062521 gagtggcggg ctgaatatcc cttgtcagaa acactactag cggcaaaaac acagaacctg 3062581 caagcgtctt tagtccaaat ttcccgccga gcaaaatgac gccagcaata aataaaggga 3062641 tattaataat ccactgtaca tacgctgctt caaaaccata tgattgtaaa atcgtactga 3062701 tcccgctgac cccgccggcg gcaatcttat tcggaagcaa aaatacatta aaggacacgg 3062761 ccgtaatcgc tgctcctatc aatatgtata cataatcccg caaaatccac aatgttttat 3062821 tccgtacgtc catcatatat cctccgtttc ttccaatgct ctccgatagc attttaatcc 3062881 ttccctgatt agatgtaaat aacacccaaa tacagtggta atatgctaaa gcagcagtga 3062941 aatcaaggat ataagaaata aaaaaacaca cccgtatgca tcaggtgtgt ttttcagctt 3063001 atgaaagctt agaacgcagg taggcatcaa taaacgtatc aatgtcacca tccattacag 3063061 cttgaacgtt ccccatttct gtattggtcc gatggtcttt taccatggaa tacggatgga 3063121 atacataaga acggatttgg ctgccccagc cgatttcttt ttgttcaccg cgaatttcat 3063181 ccagctctgc ctgctgctct tcaattctgc gctgatacag cttggccttc agcattttca 3063241 tggctctttc acggttttta atttgtgagc gctccgtttg gcatgtcaca actacgttcg 3063301 tcggcaagtg agtaatccga acggctgaat ccgtcgtatt gacgtgctgt ccgcccgcgc 3063361 cgcttgcacg gtacgtgtca actttaatat cctccgtacg aatatcaata tcaatttcat 3063421 cgttaaattc aggcatgact tcacatgaaa cgaaagatgt gtggcggcgg cctgatgaat 3063481 caaatggtga gatccgcaca agacgatgaa cacctttttc tgctttgaga tacccgtaag 3063541 cgttgtgtcc tttgatgagc aatgtcactg acttgattcc cgcctcgtca cctggaaggt 3063601 aatcgagagt ctctacttta aagccgcggc gctctcccca tcttgtatac attctaagaa 3063661 gcatagagcc ccagtcctgt gactctgtac cgccagcacc agggtgcagt tctaaaatcg 3063721 cgttattttt atcatacggc tcgctgagaa gaagctgaag ctcaaactca ttgaactctt 3063781 ttgttaatga ctttagttct ttttcaagct caagctggag atcagtgtcc ggctcttctt 3063841 tcaaaagatc atgagtcatt tgtaattctt cgtgggattc attcaatttt ttatacgaat 3063901 tgacataatc ctttaaaccg tttgcttcat ttataaccgt ttgagctttt tgctgatcat 3063961 tccagaattc cggatcagcc atttgttcat ctagctcagc aatgcgggcc tcctttgatt 3064021 cgaggtcaaa gagaccccct aaagtccgct aaacgagaag ccatattttc gagctctgct 3064081 ctaatttctg ataattccat ttcattcacc tcattaaaag atccgcaggc gcctgcaggc 3064141 gccgcggtca gtaaacttgc cggggcgaac tattcagtac ggccgcagca atttttatat 3064201 tttttcccgc ttccgcagtg gcatggggca tttcgtccga tatcaaccac tttgcgaacc 3064261 ggtgctttct ttgctttttt gttatcgtcg ccttcttgcg gctgatgagc tgttgtttga 3064321 ccttgtacaa cctcttcacg ctccagattg ttttcaatct cagctttcat cacaaatttt 3064381 gcgacttcgt cctcaattga ttcaatcata tgctcaaaca tcgcaaaacc ttccatttga 3064441 tactcacgaa gcgggttcgt ctgcgcgtaa gcacgaaggt gaatcccttg gcggagctga 3064501 tccatcgcat caatatgatc catccattta gaatcaacgg cacgaagaac gataactttt 3064561 tcgaattcgc gcatttgctc tttgccgaat tgctcttcct tctcattata ttttgtgatg 3064621 atgcgatcca taatgagctc aagcatttca tccggttctt tgccgaagat atcgctcttc 3064681 tcaagtgcac cttcatcaag ataagttgtg ttgataagat caactagacc gtcaagcttc 3064741 cactcctcag gaagctcttc tcttggcgta taggctgcaa ttgcgcgttc gagagaagac 3064801 ttgatcatat tttcaacgat ttcacgcagg ttttcagagt caatgacttc aaagcgctgc 3064861 ttataaatga cctcacgctg ctggcggaga acatcatcat attgcagaag ctgtttacgc 3064921 gaatcgaagt tattgccttc gacgcgtttt tgagacgatt caaccgcgcg agataccatt 3064981 ttgctttgga ttggagtaga gtcgtccatg ccgaagcggt caagcatcgc cattgtccgc 3065041 tcagctccga atctgcgcat caattcatct tccatagaaa gataaaattg agtaatcccc 3065101 gggtctccct gacgtccgga acgacctcga agctgattgt caatccggcg tgattcatgt 3065161 cgttctgttc cgactacagc gagcccgcca agctctttta caccttcgcc aagcttaatg 3065221 tccgttccgc gccccgccat gttagtcgca atcgtaactg cgcctttttg gccggcctct 3065281 tcaatgatct gcgcttcacg ttcatggttt ttggcattta acacttgatg cggaattcct 3065341 ttgtttttaa gcagcttaga aatcaattca gatgtttcaa cggcaaccgt accgactaga 3065401 acaggctgtc ccgtcatgta acgctgtgcg acatcctccg caactgcctt aaactttcct 3065461 tccatcgtgc ggtaaattaa atccgggcgg tcatcacgga caacaggcct gttggtaggg 3065521 atcgtgacaa cctgcatgtt gtagatgttg cggaattctt cttcctctgt cttagctgta 3065581 cccgtcatac cggcaagttt ttcgtacatt cggaagtagt tttggaacgt aatcgtcgcc 3065641 aaggtcatgc tttcgttttg aatctcaagc ccttcctttg cttcaatcgc ttggtgaagc 3065701 ccctcactgt agcggcggcc tttcatcaga cgtcccgtga aggaatcaac aataacaacc 3065761 tgtccgtctt ccactacata gtcaacgtcc ttttgcatcg caacgtgagc ttttaaggcc 3065821 tggttgatat ggtggttgag cgcgacatgc ttcacatcaa agaggttatc gatgccgaat 3065881 gctttttccg ccttcgtcat tccttcttca gtaagctgta cagcttttgt tttgatatcg 3065941 tacgtgtaat ccttctccgc ttttaacgtg cggacaaaag catttgcctg tacgtacagc 3066001 ttagtggatt ttgcagcttg tccagaaatg ataagcggtg ttcttgcttc atcaattaaa 3066061 atagagtcaa cttcatctat taccgcaaaa tgaagcgggc gctgaaccat ctgctcttta 3066121 taaagaacca tattgtcacg caaatagtcg aagccaagct cgttgtttgt ggagtaagta 3066181 atatcagcgg cataagcttc ccgtttttcg tcttttgaca ttgagtttaa attcaaaccg 3066241 acagtcaaac cgagaaactc gaaaattttc cccatttgct cagcgtcacg gcttgccaag 3066301 tattcgttga cagtcacgac gtgtacgcct ttaccggtta acgcatttaa ataaacaggc 3066361 agggtagacg ttaatgtttt cccttcccct gttttcattt ccgctatatt tccgtcatga 3066421 agcgccacgc cccccatgag ctggacttta aacggaaaca tgcctgttac gcggcgtgaa 3066481 gcttctcgaa caacagcgaa agcttcaaca agaagatcat ccgttgtcgc ccctttttca 3066541 agacgctctt taaattcaat tgttttatgt ttcaatgcgt cgtcagagag attttcatag 3066601 tctccgcgaa tcgcatcaat atcgttagca attttttcgt atctattcag cgtacgtttt 3066661 gttggatcaa acattttatt taaaattcca agcatttata acgctcctct atcatcacac 3066721 gcctatttta gaggcatgta taaataattt actagtccat gtatacctct cattatcata 3066781 tcataccttt tgttatttcc aaagaatttg caaataagaa aaacaaaaac cttccgcgga 3066841 catcacggaa ggcttctctt cattattcag tcggttcaat taagccatat ttcccgtcat 3066901 ttctgcggta cacgacattt gtaaggtttg tttccgcatt tgtgaaaaca aagaaattat 3066961 ggccgagcat attcatttgc aagatcgctt cttcactatc catcggcttt aaattaaagc 3067021 gtttctgacg gacgatgtcc aagctctcct cctcttctat gtcatcctga accgcaatat 3067081 ctgtatcaga gccaagaccg tttgccaata aatattttgg agagccctgc tcacggaatt 3067141 tacggtttac tttcgtttta tgcttacgga tttgacgttc cagtttgttt gttgcgagat 3067201 caattgcgtt gtacatatcc tcgttatgca cctcggaccg aagcgccaga tctgtcatcg 3067261 gaatcgtaac ctcaacctta gactccttgt cattgtaaaa cttcaagttg acgttcacat 3067321 cagcatccac gctatggtca aaatagcgct ccagcttgcc gatcttcctc tcgacatgat 3067381 cctttaacgc gggtgtcact tcaatatttt ctcctctgat gttatagttc atcaaagaac 3067441 gcctcccttt tattaaggat atgtatctat ttctctttta ccctttacaa ttcctgctga 3067501 aacataaatc ttttgtgaaa attcagtgaa ctttgtcgaa ttttgtttgt atttgctctg 3067561 ttattggcgg ctgctaagct tttgaatcaa acagtttcat tttgctactt ttcggcagct 3067621 cagctttaat tgatttgctg taattgaagt tattttcctt aggaaccagc atatcgtacg 3067681 aaatagagat gaattgcagc gcgtctcttg tcagctgcct attcatctca tttacttttt 3067741 tcagacgtcc gagaacttga gaaagagatt cgtatagttg ttccagctct tccttttcac 3067801 tgcctgaggt tttggcgata catgcggaaa tagtattatt ttcgctatat ccgagaaagg 3067861 ccgaagttgt tttgatccgg tcatcttctg tctgcgtgat tgcttgaata tatttttgct 3067921 cttttgtcaa aatgttagaa agctcttttg ttttgccggc tttgagcgct tccgtctttt 3067981 cttcagacag cgtgagcagg tgctcatgca gaacgcaaag tcgcttcaat tgttcaataa 3068041 ttgccttcgc tgacatgggc tttctccttt tttattgctt tttataaaaa ttaatcatat 3068101 ttttcgcaat atgatttgcg tctactttgt atgacccgtt ttcaatttgc gctttaagct 3068161 gcgcaatttt ttcctgtcgt gaaccagtga ctgcgtcgga tgcatgttgc atttctttag 3068221 cctgtgatga aatttcaatt ttatcttgag gttgtgcaac agttttttgc accgcttgct 3068281 tatcataatt tttttgatat ggattaacgg attgtgttcc aaattgattg attttcatag 3068341 gattcctctc gctttccgtt gcagtcttta aacaatctta acccttttat cgactgcgtt 3068401 ttcagttagt ttagggaatc agctgttttt ggtattatag gcatagtatg tgtctttttt 3068461 actattttct ttctcgattt tcagagcatc ctcgtggttc aaatgatcca tttgatcctt 3068521 aatatcagac tggcaagcct tgcagaactt gccttctcta atcgatgtcc cgcacctttc 3068581 acaagggtat gccaaattag gaagatgagt gatctgaatt cgcttctgcc tgatgaattt 3068641 caatatcagc tcttcttcca cacctgtttc ctcagttatc cggctcaaag ttgattgccg 3068701 gttttcctgt tttcttaaaa atttatagac agtctcaaat gatttttctt cttccttaat 3068761 acacgcctga catacggttt gcagctttgt ttttaaaaat aaagcattgc atttcggaca 3068821 attagccagt tctcccatct ttttttctcc ttattagata atatgcctgt gtcaatttct 3068881 agtgattata tcggcataaa aacagaatca tttagcttct gatcaaggta aaagatgaca 3068941 ctgaagcggc ttttcctttt tctaataagc agcgggctgc gaagtgcaag gtggcgcctg 3069001 ttgtataaag atcgtctatt aaaatgatat tcataccttc tgctgaatta ttttttgtat 3069061 caaaaatgca ctctgacagc aggcgttctg ttttcttttt ctttgactgt ttctcattat 3069121 tcaggcgaat gaggggatgg tgggaaggcc ggtctaaaca ttctgccaag agatgtgcct 3069181 ggttaaatcc gcgctcttct tcccgttcct tgctcagcgg aataggtaca agaacaaaat 3069241 gcttatcggg gtaaacctta gaaaaggttg aagaaaaatc acttttaaat gcatttatga 3069301 tttctgcatc tcctctaaat ttaaaacggg agagcgtttc tttcatcata tcattatatg 3069361 tgtaaactga acggttttga cgcaatagca aactgtctct gatccttgtt ctccacacct 3069421 cgcaatccct gcatacggca tgaacagatt gaggtctgcc gcacaggggg cagatatgtc 3069481 ctgtgatttt ctttaatttg cttctgcaag aataacaaac cttttcatca ggctttagta 3069541 aaaaaagggc tctccatgta acatcttgag aaaattgcga atcacataat aaacagatca 3069601 gtttatgaat gcctcctcct gcttcgtttg acataaatcg cttggactct ctgaaactac 3069661 tgcagcagat tcagccaaaa tgacaagcat tgctgtgttt ttttgtttat ctaccagctc 3069721 agctttcgta tatgcgatct ttttaaaatc agtaacgtag gatggactca ctttgtttaa 3069781 agaaagtgcc aatacatcgt tttggcatac ttggcaagta caggccatat gaagctggtc 3069841 catatatcgg tcgagcagtt ctttcattac gatttctttt gaattgacaa gcatttttac 3069901 agctcctcat catcggttat atgagtatac tgtaccacgt tttcaaataa tggctagtct 3069961 gtacattcaa cttttgctgc caattcattc atttctttta tatgctttct tgcatcgagc 3070021 atactctttg ttttgccgaa gtgaaagtaa atgacatcgc cgtccgcata ttctttatgc 3070081 cggccggttc ttcctgcaat ttgaacaagt gcgctttccg taaagataga cgattccgct 3070141 cctagtacac ccgtttgcac cttggggact gtgacgcctc tttccagtat tgttgttgtg 3070201 attaatagat cgagctgacc atctctgaat tgctgcactt tctcctttct atgcttgtct 3070261 tccgcgtgca cagatgcggt tcggcaatga acacctttaa agcacgcagc agccttttcc 3070321 agaatagaaa cggaaggaac gaataaaaaa acaggcctcc cttcttttac atgaaactct 3070381 atccatcttt tcaccgctgg cggaatttta tttcggttta atttcttctt ccagtttcca 3070441 caccatacaa agcgcggttc gggtaaaggt ttccggtggt gtcttgcggg gatgcgaact 3070501 gaatgtaact gtccgttcag tgcttttctt tttaattctt taggaggtgt tgcacttaaa 3070561 taaacgaggg tgctgttttt ctttcttgct ttttgaacag cgaattgaag ggtttgatca 3070621 gcagaatatg gaaaagcgtc aacttcatca atgatcataa catcgattgc atctttatat 3070681 cgcaaaagct gatgcgtagt ggaaatcata agcggagata gccgcccttt gtcatcgctt 3070741 cctccgtaaa gcgctgaaat gtcagcaccc tgaaaggcag ccttgagtct tggagcaagc 3070801 tctaatacaa catcggtgcg aggtgttgca atacatacac gcagtccttg atttaacgct 3070861 gattctatac caggaaacag catttctgtt ttgccagcgc cgcaaaccgc ccagatgagg 3070921 agctcttctt tttttgatat tgcttcaatt aaaacattgg cggctttttg ctgtccgctt 3070981 gaaagcttgc catcccatgt cagcttaata gacttccagt ttgattcatt ttcctctttc 3071041 catgaatata aaggaacctc ctcactcact ctgcccatca tgacacagga acggcaatac 3071101 agcttattct ttccagatga gtgataaaaa gaaaaatacc gctgatcagt ttgtccgcac 3071161 ctattacatc tatatctccg tttatttatg gatatagaat tttcagcagt gatatatcca 3071221 ttcttgatat gccattcaat catctcatcg gaaaatgaga gctcagtcct gagcaaatga 3071281 cggcttcgaa gcgtctgctg caattctttt gaaaaggaac tgtttttttc aactggcaca 3071341 ttcacatagc acgcctcctt tcgaaacagt atgcctgaat gaatattttc tgtccaacta 3071401 ttaaaataag aatataaaaa aatctccgct ctaaaaacgg agatttggcc ttatttaaaa 3071461 caccagcaaa ttcctaacgc accttcaccc aaatgagtgc cgattaccgc gccaaaatag 3071521 ctgttataaa attcaacatg aggatatttt gcagaaagct cttcaatgat tttcgctgct 3071581 tcttcctctc gattagcgtg gataacagca gctcgcatag gcaacccttt actcgcatct 3071641 tcgtctaaaa gctcataaat tcgcgaaatt gcttttttac gtgtgcgaat cttctcaaaa 3071701 ggcacaatta ccttattgtc aaaatgaagg ataggcttta cctttagaag actaccaatg 3071761 aaggcttggg cgctgcttaa tcgcccgccg cgctgaagat gggctaagtc atctaccata 3071821 aaataagctc gaactgtttt tttcatttct tccagttctt ttataatatc ttccggcgat 3071881 gatgctccgt ttttgattaa ttcagcagct ttaagggcat aaaagccttg agccaagcag 3071941 ctgatctctg agtcaaatgg atacacatca atattgtcga ccatcgaatc agccgctgct 3072001 gcactgctga atgttccgct gatcccgctg gaaagatgga tactgataac cgcatcataa 3072061 gacttgccaa gctcttcata caacgcaacc agctcgccga ttggcggctg agaagtcgtc 3072121 gggagctcat tatgtttttt cacttcttca taaaagcttt tccagtccaa ctcaatttct 3072181 tcacggtaag tctcctccct aaaaacaacc tggagaggga tcatatgtat ctgatgttgt 3072241 tcacgcattt ctttcggaat atatgccgtg ctgtctgtta cgactgcaat attcatagct 3072301 tcgatacctg ccttattgct ttataactct attgtaaggg aaacggcagc ctaaaaaaag 3072361 acctgcctag taaaaggcaa gtctcctatt atactatctc atttctaccc agccattttt 3072421 aatggcgacc acaacggctt gcgtccggtc gtttacattc attttttgta aaatattgct 3072481 gacatggttt ttaacggttt tctcactgat aaacaatgat tcaccaatac cgcggttgct 3072541 ttttccgtct gcaagcatct gcagcacttc acattcccgc ctagttaaaa tatgtaatgg 3072601 tctgcggatt tcagggtaaa cctcatgttg agggtgtgca gaaactccgc ttgttgcaag 3072661 gcggcggaat tcgttaacga ggttgtgagt aaccttcgga tggaggtaag atccgccctc 3072721 agccactact ttaaccgctt caattaatgt atcagcatcc atctctttca gcagataacc 3072781 tcttgcacct gttttcaggg catgtgttac ataattttcg tcatcgtgaa ttgatagaat 3072841 aattacttta gattcaggat acagctctac aagctgtttt gtagcttcca caccatttac 3072901 gtttggcata ttgatatcca tgatcacaac atcaggatga tagtgctcaa caatacgagc 3072961 cgcttcgtcc ccgtcatcac cttcggctac cacttcaaag gtaggttcaa aatccaatat 3073021 ccgtttaaca ccttcacgaa ataactgatg gtcgtcgata ataacaatgt ttactttagt 3073081 cacaagccac gcctccttgt attattgttc tatatactct agcattcggt caatatgcct 3073141 tttggctcta ttttacaaat catagtcaaa gagataacgg aaccttaatc ataataaatg 3073201 tcccaagacc tattttcgaa tctattgtca tcgttccttc caataaatct actctttctt 3073261 tcatgcccag caagccgaat gatttgtttt tcttctcttt cgcttccttc aggtcgaacc 3073321 ctttaccgtt atcttttatc attaaaatca caaaatcctt tgtgatctca actttgactg 3073381 taatttcttc agattcagaa tgctttagcg cattagacac agcttcctgt gcgagcctga 3073441 agagcgcaac ctcaaactga ggcgctagcc tctgatcctc tgtttctcca atgcactgaa 3073501 aatgtatttt gaccttcccg ttatattcct cggttgtata tagatatttt cttaaagttg 3073561 gaatcaggcc taggtcatca agggccatcg gtcttaaatc atatataatc cttctcactt 3073621 cgtaaagggc attccgaaca ttttggcgga gatttttaat ttcttggaat ccgtcctctg 3073681 cgccccggtc acggaaaatc cgctcgatta attccgatct catcataaca ttcgccagca 3073741 tttgagcggg tccgtcatgg atttctcttg agactctttt tcgctcttct tcctgcgcct 3073801 caataattct taagccgaaa tcctgttttg cctgagcatc agcaagaagc agtccaactt 3073861 cgcgcaaatc ctgattcaag tagttgagca caactgtaat ttggcttact aatgattctg 3073921 accgctcaat gatttcctga agccctagca atctgcgctc caaatcgtcc cgccgttcgc 3073981 gcaattgctt ctcacgctgc tggatcatcg tcaattctac ctgcagctta tgggcttttt 3074041 cataagcatt gcggatttcc tcttcactga atctatgaaa attacggctg acctcggata 3074101 aacggtttct cgcatggcga gtttgcactt caagtttatc gccaagctca atcacttcat 3074161 acacctgctg tttaatttgt ttcagttctt cgaccagctg ttcatactgc tggcgtgact 3074221 gctccccgat ttgaaaaacc tcgtccttgc tcccgtcaac ggttttcagc atcttcatca 3074281 aaatagaatc cagcactttg gaatccatct ttgttttatt cataatttcc ctccgtcacg 3074341 gcgttgtcat atatttttat tataaatgta attgatctgc aaattatgtc gaattataat 3074401 gaaagaatgc gtatattcta gaaaaaaaca tttttatata ctatctactc tttatgatac 3074461 caaaatacgc acaaaaattc taaagactgt acgaatttgt ataggcagtc ttttatgctt 3074521 agcaggaggg tcagctagca tgctgcacag ctattttact gtgaaagaag cgggagaaca 3074581 cgagattgtt atagaaaaat cgcgttttat ctgtcattta agccgtgttt ctaccgaaca 3074641 agaggcacag gaatttatac agaaaataaa gaaacagcac tggaatgcga ctcataattg 3074701 ctcggcttat gttattggcg agaatgatca tatccaaaaa gccaatgatg acggggaacc 3074761 aagcggtaca gcgggagtgc cgatgctcga ggttttaaaa aaacgcaggc tgaaggatac 3074821 ttgcgccgtc gttacacgct acttcggagg cattaagctt ggtgctggcg gattaattcg 3074881 cgcttatggg aaatcagtgt ctgaaggatt aaatcatata ggtgttgtag aacggaagct 3074941 tatgcgaatc atgcatactt ctgcagatta cacatggctt ggcaagattg aaaatgaatt 3075001 aagggagtca caatttctgt taaaggaaat ccattattca gaaaatgttg aattcgaaac 3075061 atacgtggaa gaaaaagaaa ccaacgcttt ttctgaatgg atgacagaac tgacaaatgg 3075121 aaagagtgat attaaagagg gagagttgac gtatcttgaa aaagccgtca atcacataaa 3075181 ggagactgaa taatggctga acgcgttaga gtgcgtgtgc gaaaaaagaa aaagagcaaa 3075241 cgtaggaaaa ttttaaaaag aataatgtta ttgttcgccc ttgcactatt ggtagttgta 3075301 gggcttggcg ggtataaact ttataaaacc attaacgctg cggatgaatc gtacgatgcc 3075361 ctatcccgcg ggaataaatc aaatcttcgc aacgaagttg tagacatgaa gaaaaaacca 3075421 ttttctattt tatttatggg aatagaggat tacgcgacta aaggacaaaa agggagatca 3075481 gactctctta ttgttgttac cctggatccc aaaaataaaa ccatgaaaat gctgagcatt 3075541 ccgcgtgaca cacgtgtgca attagctggt gacacaacgg gaagcaagac gaagatcaat 3075601 gccgcttaca gcaaaggcgg taaagatgaa acagttgaaa ctgttgaaaa cttcttgcaa 3075661 atcccgatcg ataaatatgt cacagttgat tttgacggat ttaaagatgt gattaatgaa 3075721 gtcggcggta ttgatgttga cgtgcctttc gatttcgatg aaaaaagtga tgtagacgaa 3075781 agcaaacgga tttacttcaa aaaaggcgag atgcatttga acggcgaaga agccttagca 3075841 tatgcccgga tgagaaaaca ggataaacgc ggagactttg gccgtaatga cagacaaaaa 3075901 caaatcttaa acgcgctgat tgaccgcatg tcaagtgcaa gcaacattgc taaaattgat 3075961 aaaatcgcag aaaaagccag cgaaaacgtt gaaaccaata ttcgcattac tgaaggttta 3076021 gcgcttcagc agatttacag cggctttacc agcaaaaaaa tcgacacatt gagcattaca 3076081 ggttctgatt tgtatttagg gcctaacaac acatattact ttgaacctga tgctacaaat 3076141 ctcgagaaag tcagaaaaac gcttcaagag catttagatt atactcctga tacaagcact 3076201 ggcacttccg gtaccgaaga cgggactgac agctcaagca gttctggcag cactggcagc 3076261 actggcacaa caactgacgg gacgacgaac ggaagcagct attcgaatga cagcagcaca 3076321 agctcaaaca acagtacaac gaattcaaca actgattcat cctattaaaa aatgcccggt 3076381 ccttttagag gatcgggcat ttttgcgcag aaaaaaactc cggcacataa gccggagttt 3076441 ttaattcctt ttcaccagcc gtttataaaa ctttgtaaac ggcttaaatt tttcattcac 3076501 gagtcctgtc acttctgcta tgatttgcat aaaaataatc aaaatgaaga taataaacaa 3076561 agaaagccaa attgtggcac ttttaagtac aatcgcactg atactgaaaa taaatccaat 3076621 taaataaata actaagaccg acatccgatg tgaaaggcca aaggccatca gtctatggtg 3076681 aatatgcgac ttatcaggcg ctgaaatcgg ctgtttgttt aatattcttc tgatgatagc 3076741 aaatgttgta tcaaaaatcg gtacgcctaa tataataatc gggataacga tactgaacaa 3076801 tgtgacactt ttatacaggc ctaataatga aagaatcgag atactatacc ctaaaaacag 3076861 tgatcccgta tctcccataa agatttttgc cggatggaag ttgtaaaaca aaaaccccag 3076921 cgtgctggca ataacgacta atgagagtga cagaatgagc acttttccgc cggatagcgc 3076981 catgacagca atcgttgaca ggccgataac agaaagaccg gcagcaaggc catccaatcc 3077041 atcaatcagg ttaattgcgt tcgtgatgcc gacaatccat aataccgtca gcggataagc 3077101 catccatcct aactcaaatc gttctgttaa aaaaggtact gagaaaaagt ccatttttaa 3077161 gccagtgctt acaatcataa tggctacacc taattgaatc aaaaacttaa cttttgcact 3077221 taattgatat ttatcgtcaa gaatacctaa cacaataatg atgaatgctc cgactgtaat 3077281 tgccgtcatc cttgtttctg tgtaaatacc ggatgcaagc acgcctgcaa ccaccccgat 3077341 aaatatggcc agcccgccca tgcggggcat gattttgtca tgtacttttc gattgctggg 3077401 ctggtcaact gcacctattt taatcgcaat cctttttacg attggggtta tgattaaaac 3077461 tgtcagcagc gagacaataa acgcaacaac aatgcgaatc atgcgttcgt caagcataaa 3077521 gaagtctcct ttggaattaa atgaagtctt tatttatata gagaaccgtt ccttccatta 3077581 taccttctcc ttagttatta taacaagctt catcaaaaag aaacacgtat aatcaaaaaa 3077641 cgcgcatccc aatttatagg actacgcatg tttttgaatc cctgtatatt tcataatttg 3077701 tctaaataag caattccaat cttgtgtccg ggcgatgttt cggcgcattt ctttataggt 3077761 ctcgtctccg ttttgaccga gaactttttc acaagcggct ataaaatcaa tcggatgatc 3077821 gccctctaca tattcgtata catacggctt ttgcattttt gaggttgacg gaagattagt 3077881 gcctacaaca ggttttcctg ccgctaaaaa ttcaaatagt ttcagcggaa acacagcttg 3077941 attatacggt gattgtttat atggcataat gccaatgtcg ataagctcca tataatgagg 3078001 cacttctttt ggatctgccg gaccggtcca tatgacattg ggaagcctca gcagctcttg 3078061 aaacgaaaca tcaccattgg tggcatccgg gccaacccat aaaaatgtcc aatcaggctt 3078121 ttgcagtgcc gcttctttaa tcattttaaa atcgagcttc ggtttaatcc cgccaataaa 3078181 acctaacact attccttctc tcccctgcag tatactgcga tcgggagctt gtttatttgc 3078241 agaaaacagc tcatactcca caccgttttc cacagtatga accttttctc gtcctgcagt 3078301 cagttttttg tctacttcct tgtgaagata atctgatgaa caggttattg aatctgctcg 3078361 ttgtataatt ctcagctctg ccgatttaat gacttttcgc cggaattcag acagcagatt 3078421 tgatcggccg ctgatcggcg cagcccatag gtcactgcag tcataaatga cctgatccca 3078481 agaatacagc gaagacagca gcgggaatcc gggaaacgtg taccataaac agcagcgttc 3078541 accgtttgca gaagcaggtg taagctcatc gagtaatggg gagagcttat gtctgtaaaa 3078601 gacatctgta tatcgtccga aacgaaacat ttttttctgc agcaggtctt tgacagcgaa 3078661 ttgcctgatg ccagaatgga cttcctgaaa ctctttccct tgggcacgcg gagccggaca 3078721 tacccaaata acttccttcg tttcctcctg agcagctaaa aattctgcca gccggtgcct 3078781 tctgtatctc aattggtctt ttccccattc agcagtggca acgatgacat gaatgattgc 3078841 ttcttttgtt tccaccttca tcaccttttc tctctgtttg cagctataat ctttttttca 3078901 ccgcgttttt tgcatattga acaaaacacc atgttgcttt cataaaatga agccgttcga 3078961 tctccctgta gacaaaccac gtttttttcg cagccttcca tttgttgctg gaaattgaat 3079021 tattgacaag ccgatattca gccaggcatt cattcattcc ataggcagta aatccttttt 3079081 ttaaaagaga cagccatgtg gctaagtcct gtctcgttct gatattcggc atttggatct 3079141 gtcccgtttg ctccctgtca atcatcaccg tcaagcagcc gataattgta tttttcaggg 3079201 cgtcatcgta cgtcaggctt tccggcgcat gaataaattt atcgagcggg gtcccgtcct 3079261 gcgccattaa gctgtagccc gtgaaagaga acgcacagga gcgctccatc ataaactcaa 3079321 gctgcttttc cagtttgtct tttttccatt tgtcatcact gtccaaaaat gctacgtagc 3079381 gcccttgagc gcgttccaac gctttgttgc gagcaaccgc agctccggag ttctcttcca 3079441 gatacaccac atgaattctt tcgtctattt tttcatactg ctgtaaaatg tcgcgggtcc 3079501 catccgttga gcaatcatcc acgataatca tttcccaatg aggatggctc tgatctaata 3079561 ccgaatgaac cgtgtcttca atatagtcac gcgcattata ggaaggtgta atgacagata 3079621 cgagaggttt ccaattggtc atgatcacat ctccatcgta tgattttaaa aggattctct 3079681 gaaaaattca ggaatgacaa cgaacataaa ggcaatcgta aggccaatca taacgccgag 3079741 aactgctttc tttttcggag acataccgcc gcctgctgtc tcacttacgg tttcggaatc 3079801 agtaacactt gccgctttca ggttaagctg tgtgtttttg agttcatata aaaatctctc 3079861 tttatccact ttggaatcct cgctcaccga ctcgccttca agcgcgtcta tgctgctgcg 3079921 gatgacggct tctctttctg catacagctt ttgatcgttt ttgaggaagg tggaggatat 3079981 ggcgtttaag acagattccg ttctatcctt atcctcgtca ctatagctta aagtcagtaa 3080041 cgatttggat tccgtattga ttgtaagctt ctctttgatc tctgctacat cttcatcctt 3080101 ttcatcagga agcgcctcct tcaaaaagga gtcgctcttt aatagaagcg gaatctcttc 3080161 tgtgctgtta taaaccggat gatcatagct ccccacagcc aaagtatctt cagctgtata 3080221 gctcttttga tcagcgatct gtgacggcag gatatacccc gccgcaccta atataattgg 3080281 caccgctatg atccaaatga tatttttttt tatgcgacgg gctattctta tcaatatatc 3080341 gttcatataa gtctccctgc tttttgtagt ctgtttatct gtacatcggc tcaggcattt 3080401 gtctggatcg ccttaacaca ttcacggcgg cgatgacgag cgccataaac acccaatgga 3080461 aaaataaatt tgaaacagag cttgggctga tacttgatac caggaaactg accatagcgg 3080521 taataagtcc ttctgtgatc agttttgact gattttctaa ttttctttca taaaacttgt 3080581 aaagcaccca tatgaggtag gcataaacgg acaaatatcc cagcatgatg aacaaaccaa 3080641 aattagcaag aatttcaaca agccagttat gcacctctgc cacattgtca gtatcatata 3080701 cagcataatg ctcaagataa taggatacat ttcctgcccc gactccgaat ccgtatgaat 3080761 caaggaaaaa atgccaagcg tttttcagca gatttgcccg agccacattt gatggaagcc 3080821 tgtcatgaaa tgaatgcagc gtctgcgggg ccagaaacag ctcccaaaac tttgaataga 3080881 ttttgctggc gaaaagaact gcgaaaagag caattcccgc cgccgacagc catatagcca 3080941 ttctctttaa aacaggcggc aatacaatga agatgtagac agcaatacct gcaaaaatgc 3081001 ccagaaggct ggctcttgaa ccagtggcaa aaattaaata caacgcacag agcgagagca 3081061 caaggccaat tgccttgatg tatccattct taatgttttt catcatcgtg atgtaaaaaa 3081121 agaagctgat ggataaaaag gtcgcaaagt cattttgatt aaaaaagacc gatgtcggat 3081181 aatgctgctt gtactccggt ccgctgtaca atgtggaact cgcaagatga tggtgggtga 3081241 tatgattgta aaaaccaatg atcatcagaa ataccgtcat caccagccaa atggcataaa 3081301 caatcatcag ccgctccatt ttttgcacgt acatgacaat aagataaatg aagaagatcc 3081361 ccattgccaa taaggctaaa tacttgaggc caactgttac cgacttggcc cacagcagag 3081421 aaacaaggcc atatataaac caaaaggcga aaaagagtaa aatccctttt acttgcagcc 3081481 catgccatct ttcaatatgg gttcgattcc gaaccatgcc gaaaatatga aggcaacccg 3081541 ctgcaatgag cagaagccgg taaaggaaca aactgaaaaa tccaagatga atggcaaaaa 3081601 atgcattatt taaaaaagtg caggcgatca aaatatagat tacagccata aagagccgtt 3081661 cttttgttgt aaatgcggtt gcaagcgtca gtaaaaacag gccaattgcc aacaccgcaa 3081721 gcacagcagc catctgcatg aaacctatat ctttatggat ggctcccagc aataggacga 3081781 ctccaaatat agcagcggcc agtaacgcta gcgtatggac cgctgatcgt ttgatactca 3081841 catgtttaac ccctttcctg atgtttcagg agccggcggc cgagcctagc agccggcagc 3081901 ttcaaccaag taacactttt tctttttata aattgacgct tcccaagtct ttagccaatt 3081961 cttcaagcgg caagcccgga aaatacttgt cagagggttc cgttccccga acagcgggac 3082021 ggccgataga gtgataaatg tatccggctg cctgcatctc ttcaagtgaa aataaatttc 3082081 tgccgtcaat gatgactggc tgttttaaga gggttttcac ttttacaagc tccatttctt 3082141 tcacttccgg ccaatccgtt aaaatcaggc atgcatcagt gtcttccatc gcagcataca 3082201 catctgtgta atactcgacc tgttcgccaa ggatcgctga agcttcagga atagcaatcg 3082261 gatcgtatgc ttttacatgg gcgcccagct gctgcagcat tgggataata tcaagcgctg 3082321 gagcggatct cacatcgttc gtattcggtt tgaaggctaa tcccaggact gaaatggttc 3082381 tccctttgac gcttcccata acagtcaaaa gtttatctac aatatgaaca cgctgctttt 3082441 cgttcgtttc aatgacagct tcgatgagct tgaatggata gcctgccgat tttgcgattt 3082501 gaagcagcgc ggttgtatcc tttggaaaac atgaaccgcc gaatccaata ccagctttaa 3082561 ggaactttct gccgatacgg ctgtcaagac caacaccatc agcaactttt gaaacgtctg 3082621 cgccgactcg ctcacaaatg tttgcgatat cgttgataaa ggaaatcttt gtcgccagaa 3082681 atgcattcgc ggcgtattta atcatttctg cactttctag gtttgtttta atgacaggag 3082741 catggaatgg ctgatgaagt tcctcaatga tggcagcggc tttatgactt gttgaaccaa 3082801 tcacggcacg ctccatattc atcgtgtcat gaatcgctga cccttcccga aggaattcag 3082861 ggttagatac aacatcaaat gagtatctcc cctttgaggc tttttgaacg atagattgca 3082921 ccagtttccc tgttccaacc gggactgtgc ttttatttac gatcactttg tagccgttaa 3082981 gatgctcacc gattgttttc gccgccgctt tgacgtacgt taaatcagct tcacctgttt 3083041 tggacatagg cgttccgact gcaatataaa taatatctga ggcccgaatg gcagacggga 3083101 tatcgttcgt aaaggtcagg cgctgatcca gcacattttt ttcaactaag tctgcaagcc 3083161 ctggttcata gattgggatt accccatttt tcaggcttct gatttttgat tcatcgatat 3083221 cacagcaaac aactttattg ccgatctccg caaagcaagt gcctgatacg agtcctacat 3083281 aacctgttcc aatgacagct atttttttca cagcgctcaa ccctctcctg taaaatgatc 3083341 ttccaattta taatggtcgc agtgtcttac gattaaacgg acgttttcgt gaccgtctga 3083401 tactgatgat gcaaggcctt ggcgtttttt cctgcgtcaa attgagcctg cacggtttca 3083461 tacaagtcat ctgctacttc cggcttccat atttgctcat gttcgtaccg agtgatcgct 3083521 tccgccaagg cttgagcgga tttcggttta atcagcagat gttggtgctt tccgaataaa 3083581 gacgacactc cgccaacatc cgtacaaata acaggaaccc ttagcgccag cgcctcaatc 3083641 acaacagtcg gcatcccctc actgtaagaa ggaagtacga atagatctgc cgcaagtaaa 3083701 tagtctctta cctgatgatt cgggacttgg cctgtgacga tatgcccctt ctgcgtcagc 3083761 gtcgattttg cgggaccatc cccgacaaag actgccttag gagagtcctg cagcgattcg 3083821 atcgcttcag acagttcaaa aatgcctttc tctctgacca gccggccgac atagacagcc 3083881 agacgctgat cgagcgggag tccgagtctt tttctgattt cctctttcgt ctcctcattc 3083941 ccctgaaaac ggctgagctg tatgccgatt ggcaaaaccg agctgtcaaa gcccgaaagc 3084001 tttttggctt cttcctgaag cttgtggctg actgctaaaa caactgacgc agaacctacg 3084061 gcacgcttga aggctttaaa cgcacctttg ctgtaatgcg gatagacatt cacatcactg 3084121 ccatgcaagg tcaggacata aggaatttgc gctgactctg acacgactgc cgcagccccg 3084181 cccgatggca tggcaaaatg cgcatggatc agatccggat ataggtcgcg ctgtttcatt 3084241 gtttttaaaa cggctgatgc gattctccga tgaggctgcg cccacttcag ctggccggga 3084301 actgcccgat agaaaggccg gtaaaccggt atcccctttc taatctcata ctccggtctg 3084361 acatcctttt ttcgatatgt ctttttcagc atgcggacag gtgctgaatg aaaaggccgt 3084421 gggcatatca cagtgatatc aagcccgagt ttttgcagct cttgcacctg tgtctcatga 3084481 aacacaccct ctccgggttt catactgctc ggatatacgc ttgtgatcca caaaatcttc 3084541 atgacaaacg tccttttctt agtagtttgc ttttcgtttg agggtacgct tttaccaaaa 3084601 gaaagagata gcacagcgcc ccagccgcaa ctgaaatggc cagccgcatt tctgcctgca 3084661 tactgaagtg ttcggtactg aggcttacac caaacgcgat gatgcccatc gccgcagtaa 3084721 tcagaaatgg cttcataatc gactggaaat aagctgaaag gttaagcttg atgacatatg 3084781 ccaaaagcca gcgcccaatc aggaaattaa caacgctgat aatggcatac acccatgcga 3084841 ctgtcagcag gcttcccgtc tgtacagctg caaacagtga taatccgtac agcagcagca 3084901 cgccggaatc ccaataaaac gctaagtcag ctcttccttt agccagcaac acagatccat 3084961 ttggattcat gagcactctt agtattccga caatcgcaag aacatttagg atcggaacag 3085021 cagcaagcca tttttctccg aaaaccgctg tgataaaggc gtctgacaca gacacgagcc 3085081 cgattaacag cggaaacgaa acaagcgcca gcatttttgt catattcaga aagccttctc 3085141 tgatcacgct gttttcatat ttgttttttg cgaaaatagg gaatgccacc cgtgtgacaa 3085201 tcggattgat cttcaaaacc ggaatggtga caatctgata agcgaggtta taaatcccca 3085261 atgcttcagc accaataaac cggccgatca aaatcatgtc gatatttgct cccagcctgt 3085321 tcacaagacg ggatgaaagc tgaaaggctc caaaagaaaa gaaatccttc atgcctctca 3085381 aatcaaaaac aaaagcagga tgccactttt ttcggtatac agcccaatat aaaatccctt 3085441 tactggactg cagcaggact tgagaaatca cgtacgccaa aatcgcatcc atcataaaaa 3085501 ccgctatcgc taaatatccg aatgacaata catttgaaaa aatctctatt ttgcttaacg 3085561 tattaaaatg cagctgcttt tgcagcatat actgatattg ctgtccaatt ggcgcgatca 3085621 aaaacataat cgccagaatc cgaaccagaa acaccagctc ttctctttga taaaatcccg 3085681 caatgacagg actgctcaca tataaaagaa caaacagcaa aacgcccgtc ataatgttaa 3085741 gccaatacaa tgttgacagc tggcgctccg tcgcgtcgtc tctctgaatt aatgctgcgc 3085801 caaaacccat atcgagcaca atctgggcga aaactgtaac cgttgtgatc atgccgacaa 3085861 gcccaaattc tgttaaggtc atcatatttc caagcagggc aaactgaaca atttgtatga 3085921 ttgtaataca catggttgaa atacttgtcc actttgcacc gctcatgatt tgttttgtaa 3085981 tacttggcat catattccct acttcttttt aagctcagat tgatggtgaa taatggaatc 3086041 ccgttttatc ttgcaccatc acccgtccaa actactttac aagtttttaa cataattttt 3086101 aattctaaag tgaaagtcag attgcgaatg taatataaat caaatatcag cttttccttc 3086161 ggcgtcatat cgtaaccgcc gttcacctga gcccagacgc tgtgtaaagc ctggaatctc 3086221 attctggaat ttttccgtaa atacgggccg ttccggacga gggccaatca tactcatatc 3086281 gcctttcagc acattaaaca gctgaggaag ctcgtcaatt ctcgttcttc tgataaaagc 3086341 tccgatcctt gtcacccgcg gatcttgctt ctgtgcccaa accgccccag acttctcggc 3086401 atctattttc atggaacgaa gcttataaag cttaaatggc ttcccgcctt tccctacgcg 3086461 ttcctgcgta taaatggcag gccccggcgt ctccaaacaa atcaaaattg aaaataccgc 3086521 aatcattggc agcgcaatcg ccaatccaat gagcgcaaac caaatatcca ttacgcgctt 3086581 tattgccaaa taacgagccg tcttttcaga taatgtaaaa gaatgtattt gttgaactga 3086641 gaattcacga ctcacattca tgcttttctc tgcactcact gacacacacc tcacgatttg 3086701 tttgggatgt tatgatgacc tatgccagtc agtttagcag acggatgtta attggatgta 3086761 aatggtatgt taagaagtgt gaattacgtg ttttttctga taaatgttgt taatactctt 3086821 ttactatttt atatacaagt cctatttgtt ttaatcattt catataaaaa agagacaaat 3086881 ctgtgattag atttgtctct ttcgattatc tgtaataaga tactgtgccg tcatgaatag 3086941 cttgtgcagc tttatcttta taaaccgctt gcttcaattt acttgcatct gatgcattag 3087001 tgataaaggc agtttcaact aaaacactcg gcattttaga atatttaata acatagaaag 3087061 cagctgtttt tactccccgg tctctcgttc caagattagc cgctaacttt ggttgaattt 3087121 gttcagccag tctcttgcta tttgcagctt gatatgttgt atcgtagtac gtctcacttc 3087181 catttggtga tgagctatca ttagcatttg catgtatact gagaaataaa tctgcttgtg 3087241 cagaagctgc tttatttact ctctcctgta aagaataaaa agtatcatta gatcttgaca 3087301 gtactggaag agcacctgaa gcatttagct ttgtattgac tcttttcgct atatcaaggt 3087361 tgacttcttt ctcaaggagt ccattgccga ttgctcctga atcttgatca ccgtgacccg 3087421 gatcaataaa gattgtttca cctacaactg gattctttag ctgattagca acctttgtgc 3087481 ttacggcagg agtgtttccg ataatcataa agtttgacat gtttttactt ccaataattt 3087541 tacgggctcc tgtagataaa ttttcaccat ttgtaagaat aagagattgc ttcttcttag 3087601 ctgccagtgt agctcctgca atagagtcag ggtagctgaa tccattgctt acatatacgg 3087661 tgcttgttga taaattaagt ttttgtacga tatttgcagc aagctcatat ctgtttgaac 3087721 cgctaattct tgtaggagaa ggtaacttgt tgtataccgt attgctgata cttccagtgc 3087781 ctcctacaac aacggtactc gaaattccct tatcttttat cacagacgta gtcgcactat 3087841 ttatagatgt tttatttgta aaaagaattg gatacccgtt tttcgctgca taagggatga 3087901 cggccggagc gtctgcatat aagaagccgt tcaaaataac agcttttgaa gtcgcaccca 3087961 tcgcttttgc cacccgtgca gccgtatcat aacggttgct tcctgcaatt cgtttaatac 3088021 ttatccccaa gcttttaatc tggttagcag tgttagaaga aacagcaggt gttccgccta 3088081 caataattac atttttagtc tgcatctctt tcaatcttgt tttcgtttca tatgaaagct 3088141 tatcagaatt agtgtaaagc aatggcgcat tcttctggta agcaagaggt gctgctgaaa 3088201 tagcatctgc ataggaactc ccaccaacaa ttacagctgt acttgctgtt gaatacattt 3088261 gctttgatat ttgtacagca gtgccgtatc tattgcttcc cccaactctt ttcactgagt 3088321 tatcggccaa agctgttggc acaaaaagta tgagccccag aaaacacatt gttaggactt 3088381 ttatataaga acgcaattga tttcctcctt aaatggcgtt atatcctaaa ataatcaata 3088441 acttgtcaga gttgtacctg gatagtaaaa tttcaaaatt gaactatatg aatctccagc 3088501 ttctgctctt gcttttgctc catattgact cattccgatc ccgtgaccat atcctttacc 3088561 gctgattgtg tactttgaag tatctttttt tacagtcaca taagtacttt taaatacagt 3088621 cgctccaatc attgttctta actcacttgt tggtacacta atggttgtaa ttttgctcaa 3088681 gttataggag ccagtactgc ttttaacaaa atacttcact ttcatcgatg ctgtttttgc 3088741 acgctgccct tgtgtcgttc cactaaagct taaatcgtca atacttgcaa ttttgacaga 3088801 atcagcgctt gtttctttat ttttcaagat ccagttctta actccggaaa gtcttgcaga 3088861 atcagtttca gtcgctgaag accaccaaga agaaggcttc gttaagtcca aagatttcgt 3088921 atctagctgt tgttttgaca aagtaagcgt ccagcctatt tgaggatcct ttgtatcttt 3088981 ttttgcaatc aagtaaggta cacttgacga ccacacttca ttactagctt ctgtgtaacc 3089041 accattactg gaagaataag ctgcagttat aagagatcca ttatatttca gaactttccc 3089101 cttcgtttgc tctaccgctt tattggtatt cgaattccaa ctgtagccac cataaacttg 3089161 aaaagcggtt gtatcaggta cagtagttcc tgtttttgtt attgagtagg ttcttgcagc 3089221 gacagtctgt gctttaagag cctcaagtga ccagctagca ggcatttcat tcggaattac 3089281 tccttttaag taatcctcaa atggaatatt ctcatttacc ggtcggatat atttagtaga 3089341 ctcaatagag aaattaaccg tgccaagata ctgctttcca tcaagactaa ttctgtttga 3089401 agtagaatag ttttctggtt taattcttag ggagtttccg taagttttga tgttttcaag 3089461 gtttaatttt ccgctgttga tttttagatt ataggtgcca ccgtcagcta aataaaattc 3089521 atcagcaagt gaattctcaa cttcagcaga aattgaactg gtacttccaa taaagtcgta 3089581 tgcatatgtg gctttatctt tcgttatact tttagccgca gccggaacgc tatcttgttt 3089641 aacaaataaa atttggctgt ttttcttcga ggcaagcgaa gcgcctatca atacgtctgc 3089701 atattttgtc ccgttcgtca ttacgacttt atcagccttc aactttagtt gcttaattat 3089761 atttgccgta agttcatatc tggttgatcc aggaatcctt tgcacagttg aagttttttt 3089821 aatttggttt tctacactat cactgacgct aaatgaactg cctataatga tgacttgttt 3089881 tggcaaatca taatccggaa gcttgtcttt ctctgtaagc aaaatagggt atccgtgtgc 3089941 tgctgcatat ggagcaatgg ctaaagcgtc ttgaaatact cttccggtta caacgatcgc 3090001 tttatcatag ctgcccattt gctttgcaat attttctgat aagacatatc tattttttcc 3090061 gcttatcctt ttcacagcgc catatgattt cagcttgttt tctacgtctt ttgaaatgct 3090121 tcgcgctccc ccaatgatta aaatattatc agggttaaac ttagcaattt gtctttcagt 3090181 agtttttgtt aacgtgtcag gctgagtaaa taaaactggt gcgttcagtt ttttcgccaa 3090241 tggaataaca ggcaatgcat caataaaaat atctcggttc accaatatca ctgtattagg 3090301 atttttccac tggctgttgg atgcaagagt cgcagtttcg tatcgtgaag cgcctgcaaa 3090361 acgatccgta acagcaacat tatctccagt tactttataa aatcctgttg gcgatagact 3090421 gatgctagat ttatttccaa tataatttaa caatttaact gagatgtttg agtctgctgc 3090481 aaaagaaact gatggaatca ataataagat tgcagcaagt gaacacacta tcaattgttt 3090541 gcaagatttc aaaatttcag gttcctccct atatcttagt tggcacgttc aatatctttt 3090601 aacagaagct gaccctcatc atttttttca tatgtaatcg tgaccttatc tccactgtta 3090661 aacttatcaa gatcacttgt cgattcttca gtgatatcaa gactaaccgg ctcattatct 3090721 actgttactt ctattgtatg agtatcagct aaccctacat aagtaccttc ttttgtttca 3090781 atgttactgt ctggcgatac atcttcacct tgactctttt gactattaac cccgcaaccc 3090841 gaaagaagca atataaagaa cagtaaagca ataaattttt tcattttttt cacctcatta 3090901 tattttatcg tcaacctatt ttatatttta aagaaaaatt aagaaacaat gaaacttttt 3090961 tttataaaaa acgactattt taggatttca ttcttgtatt aaatagagtt gtatttattg 3091021 gaaatttaac tcataatgaa agtaatttaa cagacgaggt gcaaaggatg agaaacgaac 3091081 gcagaaaaaa gaaaaaaact ttattactga caattttaac gataatcgga cttcttgtac 3091141 tcggaactgg cggctatgca tactacttat ggcataaagc agcttcaacc gtggcaagta 3091201 ttcatgaaag cattgataaa tctaaaaaga gggataaaga ggtcagtatc aataaaaaag 3091261 atcctttttc cgtcttaatc atgggtgtgg atgaacgcga cggcgataag ggccgtgccg 3091321 atacgctcat ttatatgacc gttaacccaa aaacgaatac aaccgacatg gtcagcattc 3091381 cgcgtgacac gtatacaaaa attatcggaa aaggcacaat ggataaaatc aaccattcat 3091441 acgctttcgg cggcacacag atgacggtag acactgttga gaacttcctc gatgttccgg 3091501 ttgattattt tgtgaaagtg aacatggaaa gctttagaga cgttgttgat acacttggcg 3091561 gcattacagt taacagcaca ttcgcgttca gttatgacgg ttattcgttc ggcaaaggag 3091621 aaatcacgct gaacggaaaa gaagcgctcg cttatacccg gatgagaaaa gaagatccga 3091681 gaggcgactt cggacgccag gaccgccagc gccaagtcat ccaaggtatt attaataaag 3091741 gcgctaatat ttcttccatc acgaaattcg gagatatgtt taaagttgtt gaaaataatg 3091801 tgaaaacgaa cttgaccttc gataacatgt gggatatcca gtccgattac aaaggtgcgc 3091861 ggaaacatat taaacagcac gaactaaaag gtacaggcac gaaaatcaat ggaatttact 3091921 actaccaagc tgatgaaagc gccctttccg atattacaaa agagctgaag gaaagcctcg 3091981 aaaagtaaaa caaaaagaag cttcgcacaa tgtgcaaagc ttctttttta tttgcctgta 3092041 aatgaatccg gttgttcttt tcgatacccg taatgaaaca gcaattcttc cacaatccgg 3092101 cgggaagcct ctccatctcc atacggatta gaagcctggg acattttctt gtactcatca 3092161 ggatcagtta acagctgttt tgcaagctga taaatgtttt cctcatccgt acctgcaagt 3092221 ttcagcgttc ccgcttccac tccttcaggc cgttccgtcg tatcacgcag aacaagaacc 3092281 ggtttcccga gagatggggc ttcctcctgc acgccgcccg aatcggtcaa tataaaatgc 3092341 gatttcgctg caaagttatg gaaatcgatc acctctaaag gttcaatcag atgcactctg 3092401 tcagaatcac caaaatgctt atgagccgct tcccggacaa caggattcag gtgcacaggg 3092461 taaacgactt gtacatcttc aaattcccct acaattctgc ggatggcctt aaacatgttt 3092521 tccattggct cacccaaatt ttcccggcgg tgagcggtca agagaatcat tttatcctca 3092581 cccacctgat cgagaacagg atgtgagtaa ccatccctaa ccgttgtgtt gagtgcgtca 3092641 atcgctgtat tgcccgttac aaaaatagag tcggcctttt tgttttcttt taataaattg 3092701 tctttcgcct ggcctgtcgg agcaaaatgc aaatcagcaa tcgcccctgt catctgtcga 3092761 ttgagctctt ccggaaacgg ggaatactta ttccctgtac ggagccccgc ctccacatga 3092821 ccgacagcaa tttgatggta aaaagcggct aggcttccgg caaacgtcgt cgtcgtatca 3092881 ccatggacaa gcacaatatc gggtttgata tctttaaaca actcatccaa tcttacaagt 3092941 gcgttagacg taatctctgc cagtgtctgc cgctccttca taatgttcaa atcgaagtca 3093001 ggcttgatgt gaaacgcatc taacacctga tcgagcatct gtctgtgctg tgcagttacc 3093061 gttacatagg aatctatttc aggatatttt ttcaattcaa gcacaagcgg tgccatcttg 3093121 atcgcttcag gcctggtccc gaaaacggtc atcactttta gttttttcat atttgtcacc 3093181 tggttttctg ctatagtaaa taaattcata ctacatattc tacatgaaaa tgcatcattt 3093241 taaatcattt cattcttgat tcaaataaaa tgatataagt tttaatatta aggataaagc 3093301 ttgtttaaaa atggtttatc cgatatcata aaaatgtgta aaaacatatt gaaaagggta 3093361 aatagagaat agtttaacca taaatttttt cgatcataag gaaggtgcct tttaaatgaa 3093421 aaaagtacgt aaagccataa ttccagcagc aggcttagga acacgttttc ttccggctac 3093481 gaaagcaatg ccgaaagaaa tgcttcctat cgttgataaa cctaccattc aatacataat 3093541 tgaagaagct gttgaagccg gtattgaaga tattattatc gtaacaggaa aaagcaagcg 3093601 tgcgattgag gatcattttg attactctcc tgagcttgaa agaaacctag aagaaaaagg 3093661 aaaaactgag ctgcttgaaa aagtgaaaaa ggcttctaac ctggctgaca ttcactatat 3093721 ccgccaaaaa gaacctaaag gtctcggaca tgctgtctgg tgcgcacgca actttatcgg 3093781 cgatgagccg tttgcggtac tgcttggtga cgatattgtt caggctgaaa ctccagggtt 3093841 gcgccaatta atggatgaat atgaaaaaac actttcttct attatcggtg ttcagcaggt 3093901 gcccgaagaa gaaacacacc gctacggcat tattgacccg ctgacaagtg aaggccgccg 3093961 ttatcaggtg aaaaacttcg ttgaaaaacc gcctaaaggc acagcacctt ctaatcttgc 3094021 catcttaggc cgttacgtat tcacgcctga gatcttcatg tatttagaag agcagcaggt 3094081 tggcgccggc ggagaaattc agctcacaga cgccattcaa aagctgaatg aaattcaaag 3094141 agtgtttgct tacgattttg aaggcaagcg ttatgatgtt ggtgaaaagc tcggctttat 3094201 cacaacaact cttgaatttg cgatgcagga taaagagctt cgcgatcagc tcgttccatt 3094261 tatggaaggt ttactaaaca aagaagaaat ctaaacaaaa aggctattgg acattcatcc 3094321 aatagccttt ttttatttca acatcaaagt caatgtatgc tcttcattat caactgcgaa 3094381 gacctgatca acggcctgcc gcaaaaatta ataatcccag acaaacacac tgattgtaga 3094441 gttaaacaaa ctaaatgaaa acataaatac aaacatgcag attaaatagt aaatatcttg 3094501 tattcaatgc aagctaagta aacaccactt gctaaaagaa caatgactaa acaaccagca 3094561 ttacaaaata attaaataaa tttgaagcaa ttacaacaga aggcagtgaa ctgtcggaaa 3094621 gttcattttg gctaccatat taatcccttt aactacgctg ttggatttat caagaattgt 3094681 cgggctaata gaaaaccacg gaatcaaacc agccagcatt caaacgataa aaggcacttc 3094741 tccgatacct gttatgacca gcttactgtt gcgcatccca aatacaaacc agtacgccat 3094801 cattagaata aggggattta aaacctgcca taatacacca aaataattga ttttttggat 3094861 ctttcggtta aagaaattta aaagtaccag tgaatattgt aacaaatgtt gagttttttt 3094921 cacttttaaa aagtaaagag aagtctcgca gaacttctcc caacatttga agtgtcaata 3094981 taaaacaaac caacctcatt tagcaacttt attattatct aattccaaaa tagcattata 3095041 aatacgattc ctattatttt tatcagtata tgcaaaaaag ttatctactc tttttctata 3095101 cttatcttcc atacgactat tgtttttcat ataatagata actttatcca ctaagctatt 3095161 atgattttct aatacatcac caaaccccat ttttttataa tcataataat caagtttaaa 3095221 atggtatgac ttttcgtatt gataataaat aacaggtttt ttctcatatg caaaatcaaa 3095281 cgcaacagat gaaaaatcag taatcattat attagaagaa ttaaatagca tttgatagct 3095341 gctgttatag tcggcaaact ccacataatc atgcttttca aagtctacaa tctgttgctg 3095401 aatatctggg tgaggaaaaa aagttatttt ataattattt ttcttagcaa attcgattag 3095461 ccgttcatca ttaatcaaag cattatacct agaaaaatat tcactatctt taaatttcgg 3095521 gttgtacggt cttactcctt ttgcctgatc tttcggtaat acaatatctt ttctccaagt 3095581 cggcattatt agaagttgct tttctccctc actcttctta agattatcgt atctcggaaa 3095641 tccacccaac aaaatattct cttttttata gttgtaattc cctttcacaa tagaccgata 3095701 ttcaggtttg gcagaagtga ctaataattt gatattcttg ttgtatttgt ttaaccattc 3095761 agaatgatct gccattgtta ttccgtgctg taaaaagata aactcaaagt taaataaatc 3095821 tctaaaataa atctccatat taaaaaatgg atttacaacc catatatctg catgtgtcga 3095881 tattactttg gaagaggata aggttaaaat tttatgtcta aaagatctgt atggtatgac 3095941 ctttccatat tttttgattc tgtcgtaatc cttgctatct ttttttatta taaagtattt 3096001 ttttacccca tcattcttgt tgattgcata tttaaagagg tgctcggcat tatcatcagc 3096061 tttgtcttgt ctgtctatga ataaccatac tggttttcta ttaaaaatag tgaaaacatg 3096121 gtgtaccatt cttgccatca gtgccttctt aatcgctgat tttcgttttt ttgatttttc 3096181 ccctgattta tgtagggatt ttaagaaacg aaactctttt ataaatctat ttttaaaatt 3096241 gttttttttg aacattaatt ttttataatt ataataaaaa atataatctt ttttagccac 3096301 ataagtatta tataaatcgt ttgacaaacc tgaatacttg aaaaaacgaa gttttgtcaa 3096361 cttccttttt ttacccttag ttataaaaaa ctcaatatga tgattatctg ctagatgacc 3096421 tttgggaata tctattgaaa aaccgggata tttttttatt acttctccta aacttatata 3096481 atcattatgc tgtcttttta tattctttgc ttttattttt gtttcgccaa ttttagcata 3096541 aaacttaaaa cctttagaat taaacagcga gctccaaaag ccttctatgt gaatggaatc 3096601 ctcattttct tctaaaattt caatagttaa agtttgatcc gataatttcg aaacaatttt 3096661 accttctctg tataaataat aatcctgttc agtttctctt tcatatacat acctactata 3096721 attttcaccg tgctttattt ttaaagcatg atataaatag aaatggctga cactttttgt 3096781 ttcaatgatg acatcgtcgt caatatacga caatacttct cgaatcaatg ttaaaaattc 3096841 actgtattca ttttcgtcta aaggtgtttc actgatatcc ttaatcaata atttccactt 3096901 caaatcatgc ataaccatat attgaagaaa taaaggtatt ttctgttcat gattttttat 3096961 aatatcgatt aaattctttg agaaagtgat aagtgaatgg ttaaaccaat tcttatttgc 3097021 tttagcagtc tgcatggcag atgatccatc ttctctaact ctataatggt attttgcctc 3097081 tttaaccaga ccatactttt tcttttgcga tatgattaaa ttaactagtt tggcatcttc 3097141 acctatttta caattttcat caaacctgat atttttcaag gcatcttttt ttataaatgt 3097201 agaacaacaa tgagttaata tatgatgcgg ttctttttct acatccaaaa ttcttgtaga 3097261 agaaaactta ttatttagat tatgttctcc agttcttcct tctgcaaaaa aaatagggat 3097321 tgctacaata tcaatttcat tcttatgttc gtcaaagaag tttaaaacat tttcgaatgt 3097381 tccttctgaa actaaatcat ccggatccaa aaattgaata tatctacctt cagcatactt 3097441 taaaccataa tttcgagcac tgctcactcc gccattctgt ttctttgcat agacaatgtt 3097501 attgggatat ttctgagcat attctttaca aatgatttca cttttatcgg ggctatcatc 3097561 attcaccagt attaactgaa tattctcaaa accaatagtt tggttaatga tactttctat 3097621 agcttcagtg agatacaact caacattata aatcggcatt ataacactga aatcatagtt 3097681 aaaacttttt tcgttcataa aagattactc ctaacataat gtttatatga ataagaattc 3097741 gggtaaataa aattaagaaa caagagagta ctaatttttg caaaacaatt ttaatttagt 3097801 aaaatgtatg aaaagcattc cttacctttt tttaaaaacc cttgtaagca aacttttaaa 3097861 aatgttcaca tggttaagtt ctaaagaatc atttggtgtt tttagtacaa agtcaaatgc 3097921 aaaggcccaa atcggtattt cgacaacaaa accagcatat ctaaaatctc ttaatttata 3097981 tccccatact tcaattgttt ttttcagttc ttttcgtttg cattttttta atcttttaaa 3098041 atattttata tatattctgt cattttcttt catctcataa tactggttaa taaagtgccc 3098101 tgttaattca agtctaagcc cttttatttt tgccgaagta acagtacatg aactatgcag 3098161 tactctttct ttttttatat tttcaagagc ttctgtattt tcttttaata agtgaaacat 3098221 aaattcttta tagtacatcg gcatatcttg ttcttttata aattgcgggt caataaattt 3098281 taaaacttta ataaaatcat caacaaaaac tctttgttct tgttgatcta aaacagactt 3098341 ataaacatct ctatagttcg gatataaaaa cagttttata tgatatacaa ttaaaaattg 3098401 caaataaggc aaaactatat catatttgtt gaatgaatcc atcaacaaag tcatgtaaca 3098461 ttcattcaac aaatatgtgt accttttttt gttaaaccat gaacgatcaa ctaaagaatc 3098521 ctgttctttc cgttttctat aaaaatactt tccttctgca actgctccgt atcttttttc 3098581 tttcagtaat aactggttaa aaaagatagc gtcttcccaa aactttatag attcatcaaa 3098641 aaggacggta ctagttagtg tatgtcttct gtaaaaagtg ccgccaatat aaaaatgaat 3098701 agctttataa tcgttgagaa tatttataac tcttgttcct ttttcaaatc tattatttaa 3098761 tttatgtccc ccttcttttt cacctgtgta ataaacaggt aataccgcaa tatttacatg 3098821 ttcggaatca caaaaaaaat cataaacact ttgcagcgca ttttgagaga atgcatcgtc 3098881 agaatcaaga aaaccaataa atttagatct ttcgcttaca tttgataatc cacaatttct 3098941 tgcagcagaa ggtccagagt tttcaatttt catgatttta atattattag gatatagatt 3099001 tttaaaggat tcacaaattt gaggactgct gtcaacacta ccatcatcta ttaatatcag 3099061 ttctatattt tccttaaatc caattgactg gttaaggaca ctctctattg aatatcttaa 3099121 ataattttca gaattatata ttggtataat tatagaaaac atgtttgtac ctctttattt 3099181 agaagttaaa ggatcgtttc aattactctt ttagaagcct tgcctcttct aaattacaaa 3099241 atttattata aaaatcctca tagttatgat ctatataagg attatgtaac aactctttta 3099301 ccgtatctat aagttcttca cttgtttgaa gcaagtttcc tggcgttttt tgctgaaaat 3099361 taaagtaaaa acctctgata cagtctctat aagccgggag atcatacaca aaaaatacaa 3099421 ggttttttta aaaattcata ttatcaaaaa agacagaaga ataatccata atcaataaat 3099481 cactaattaa atataaatct cgaatatctt tatttaaaga aacatcgttc acaaaatatt 3099541 tatatttccc taattaaatt gttctgaaac tggataatac cattcttaca agaataacca 3099601 tagagtctcc aaggttccct cttcatttcc tctaatcaaa ttaaagttaa atttatactg 3099661 gccagctttc ttaaaattca ttatcccgca aagttggtgc atataaaatt atttttcttt 3099721 aattccttat ttgataatgt agaattggta ggggattgta gctaaactgt ttccagaata 3099781 gctttcaaat aaaattaatt tattgtttct tggcagaagg acaaaaattt taaacaaaac 3099841 tgaataaact ctaactagta aacttctgca attggttata ataaaaattt catcagtgaa 3099901 ctccttaaag agtgaagatt aatatttacg caaacaagaa aaaaagaagc aactgaattt 3099961 acttcaagcc tcttttagtt agtgcttcta taaactagcc atatcttttc tgatttgggt 3100021 agttgaaatg cctgctattc ttgtaaggta aatggcctca tagtattcct ttgtagacaa 3100081 tcgtacgatt aagtaatccc aggttctttt gctctttcca gtagcttcat atgtccatag 3100141 tgaaataaat caaacattcc gtacgtatca ctttcttcat tagataacat caccttccaa 3100201 ccttttccaa cttagaaaaa acaaaaatcc ttaactgatt gtttatcatt tcgacatatt 3100261 ttttacgttc cattaataat aaacaataat agcatatgtt cctataaaag ttaaggctct 3100321 ttaaaaatgt aaatcatcag cactttttga caatatcgtt gcattgatgt gtatttttta 3100381 cagatctgat atcttatcta tactcattac aacaagtttt ctattccgga agagtcaatt 3100441 ctttttgtcg cgttttcaag tgtaatgatt ttctttctgc tgcgtcattt attttgtacg 3100501 ccctcctcat attacttcat cgtcaaaacg tgaaggaatt gtaatacgta gttcctaaaa 3100561 attttcgtgg taaaatttag tgaagtcttt atcaggctaa gggactttat ctaaactacg 3100621 aattacatat ggagatatat agatgaaaag gagggttgat atgatataaa cgaaaatcaa 3100681 ttagataaag gaaaaactga acacttctga aaaaagtgat aagtttcttt cactatatcc 3100741 tccaaaaaga acctaaaggt cttggacatg ctgtctggtt cgcgcctaac tttatcggcg 3100801 atgagccgtt tgcgtttctg cttggagacg atattgttca ggctgacaca ccagggttgc 3100861 gccaattaac ggatgaatat gaaagaacac tttcttctat tatcggtgtt cagcaagtgc 3100921 ctgaagatga aacacactgt tatggcatca tcgccccgct gacaagtgaa ggccgccgtt 3100981 atcaggtgaa aaacttcatt gaaaaaccgc ctaaagacac agcaccttct aatcttgcca 3101041 tcttaggccg ttacgtattc acgcctgaga ttttcatgta tttagaggag cagcaggttg 3101101 gcgccggcgg agaaattcag cttacagacg ccattcaaaa actgaatgaa attcaaagag 3101161 tgtttgctta cgattttgaa ggcaagcgtt atgatgttgg tgaaaagctc ggcttcatca 3101221 caacaactct tgaatttgcg atgcaggata aagagcttcg cgatcagctc gttccattta 3101281 tggaaggttt actaaacaaa gaagaaatct aaacaaaaag gctattggac attcatccaa 3101341 tagccttttt ttatttcaac atcaaagtca gtgtatgctc ttcattatca actgcaaaaa 3101401 cctgatcatc tgtattcaca agaaaacgct tcttgctgct gtcatacaat acatcgctat 3101461 cacttaagga tagtgacgcc gggttgatag gagaaatgtt atgaaaaata agctctgttg 3101521 ctttatcatt ctccagtaca taactgattt tttcataatc aaaattcagc gtttttctgc 3101581 cgtcagcctt atttccttca gtataaccat tcaatttcga ttgaatgctg gtgctgctgt 3101641 ctcctaggaa tttcagaaag tattcatagg aagatgctgc gttttgcgag acataagacg 3101701 taaatgcagt ggcatgcaat tcagcgtgtt tcatgttagt tgcaacagcg ctctgtttca 3101761 cataataaga gtgcccgtca aactttattt tcgctgcttg tttgcctttt gcagctaccg 3101821 ttacttttgt accgaatggc agtgtaacgt cagccttctg tttcaaaccc tgatccttat 3101881 aagcagccgc tttttcattt gctataaacc cttgcttatt gattgcagtt aagcgttcct 3101941 ctgacttgcc ctttgcatcg ccatgatggt tcttcacttc attttgcgga atagcgccaa 3102001 acgaagcaat tgtacgaagc ggggcattaa agaacatcgt tcccgccatg aagacagtca 3102061 gaatagacaa aatagcaatt tgaatggcat tggccagtga tttcggcttt ttcttctttt 3102121 tgcggaaacg ggcaaacgct tcaggatctt ctttcttcct ctcttctgtc tgctcttttt 3102181 tatatgtctc tttttctttt ttcgatagct tattaaacca gtcaataaac gctttgtact 3102241 ctttcacaac cgtttttgtt tcatcaaaca tacgaagctc gccatagtgc atccaagcaa 3102301 cacggtcaca catcttttca atctgaccga ttgagtggct gacaaagaaa atcgtttttc 3102361 cttgcttttt aaactcattt attctgtcta cacacttctg ataaaacgtt tggtccccca 3102421 cagaaagagc ttcgtcaata attaaaatgt caggatcaat atgcacggag atcgcgaaac 3102481 cgagacgcga cttcatcccg ctggaatagt ttttaaccgg ctgattaata aaatcgccaa 3102541 tctcggcaaa ttcaacgatg ctgtcataca tatcatcaat ttctttattg gttaacccca 3102601 tcatcaaaca cttgagccgg acattgtccc ggcccgttaa ttggttattc aaaccggcag 3102661 caatcgcaat cagcgacggc tggccgttca tttcaatttc accgctggtc ggcggaataa 3102721 ttttagccag caggttagac atggtcgatt ttcctgaccc gtttattcct acaaagccga 3102781 ttgtctcccc ttcatacacg tcaaaggaga cattccgcac agcaaaaaaa ccattatcct 3102841 tagccggaaa aaacaatcct ttaatcttgt ccgattgttt tttatacaaa tgatactgct 3102901 ttgaaacatt tcgaaacgaa acttttagtt tcatcgtaaa atctccttac gtattaaaga 3102961 aagtcaacaa acttgtctct gaatttcata tgcaggatag aacctactaa caataaaagg 3103021 aatgtgaaca accaaaagta cagcgtgtac ttcatgtcat ggaaaaacca tgctccatct 3103081 aagaagctgt tccggaatcc ttcaataata tagaatagtg gattcaactt cagaacaggc 3103141 actaattcgg ggtggctttg accgagtttc gcattaacat cccaaaaaat tggcaacaag 3103201 aaaaacaaaa gtcttgttac ggcctgcagc aaaaattgat aatctctaat cagcacactg 3103261 atcgttgagt taaacaaact aaacgaaaac ataaaagcaa tcatacagat gaagtaataa 3103321 atatattgta accaatgcac actcgggaac acaccattaa ctaggagtac aatgatataa 3103381 atcaccatca tgatcatata actaaataag ttagatgcaa ttgccacgga cggtagagaa 3103441 ctaatcggga agttcatttt agccaccata ttaatgcgct taaatacact atttgatcca 3103501 tcaagtatag ttggactgat gaaaaaccat gggattaatc ctgccagcat ccaaataata 3103561 aaaggcactt cgcccgctcc ggttgtcaca ggaccgccct ttctaatccc cataccaaat 3103621 acgaaccagt aggccagcat ttggataagc ggatttaaga actgccataa gacacctaaa 3103681 taattcattt gatatttaga cttggtttca taagccgcca atcttaaaat taaaggaaat 3103741 gacgttattt gctctctgag tatacgcaac aaatcattca ttttttatct tccttagact 3103801 taattgtttt tgggaatctt tctgtttaaa atttgaaagc accgctgatt attgtaacag 3103861 atcctgcatt ttttttcact tctcaacaag tatctaaaaa gctgccgaaa aatcgacagc 3103921 tatacatttt ataaaataac ctaaattatt cagctttaaa tacagtatta acaacctttt 3103981 cagatgaacg tcctgactct aaatagcaaa acttatcata gaaaggacca aaagaaaccg 3104041 gaagcttata atcaggcgat gagatctgct tgatagcctc aatcgtttct tcagtagttt 3104101 ttaccaaagg accaggagct tctttttcaa aatcaaagta gaaaccacgc aacttgtccc 3104161 ggtaggtttc gatgtcaggg acaaagaata gcattggccg ttttaaattt gcaaaatcaa 3104221 agaatactga agaataatca gtaatcagca aatcagaaac catatacaat tctcgaatat 3104281 cctcataagc agaaaaatca tatgcaaatc cttcaaaagg acctaaatca aaattctcag 3104341 ctaccagata atgcattctt aagattacaa tatattcatt tccaagttct tgtctaagtt 3104401 gatgcaaatc taaatcgaga tcgaacttat aacgcccttt tgcatagaac tgatcatctc 3104461 tccatgtagg ggcatataaa ataacctttt tatcacgagg aatatttaac ctactcttta 3104521 tcaatgatat tgtttcctca ttattatcat tatgaagaaa atcatttcta ggatatccag 3104581 attcaatcat tgtcttgtta aactgaaacg cccgtgtaaa gatctcagtt gaataaccat 3104641 ttggggaaat caagtaatcc caattagaag cttccttgat aaaattcctt ttatattttt 3104701 tggtgtttgt accaggcata tggacttctt ccatatccat tgcaagtctt tttaaaggtg 3104761 tgccatgcca tgtttgtaaa tatgttgtat gactaggttt cggaatccat aatggaagcc 3104821 ggctgttaac aacccaatac tcagctcttg ccatagcgaa gagccatttt aatgagaggc 3104881 gattaatgta aggaattccc ttttcatcaa aaggcgctga atattgttta tttacactcc 3104941 aatacatttt atactcaggg tggttttccc gcatatattc gtaaatcgct ctcggattac 3105001 aactgtattg tttcccatta aaactttcaa aaatgactgt tttcctttta actggcattc 3105061 tgctagccat catgaataga gatttgtatg ttttagtgat taacttgttt ctcatttttg 3105121 tgatcttttt tatttttgat actaatctct tcttctttcc tttaataaag tatttcatcc 3105181 ttgttttcag gctatagtcg tttactctga tacctagagt ctgctttttc tttttcttaa 3105241 agacttcata acgaactggt gcgttgtttg ttttaataat acttactaat ccttttaatt 3105301 tgttttttcg atctcctaaa acaagagcag tgctgttgaa ctgaatatcc gttccttcat 3105361 cgtcattgca tatatactcc ataaaaagac gataaacata acgtttttca tttgagaaag 3105421 gaatttcttt caaaggcact ttcacttcaa aatcatacag ttccggaaca aaaccatctg 3105481 ctctcatgtt ttccaggcca tgtgtttttc tttctagctt gattggaaat ttttcctcaa 3105541 taggtgtttc tccacccttt tttaaaataa ggttcaagtt ttttatccga tattgatttt 3105601 cggaactcag gtaccccgca taacctgtta tgcttatttc ttcagagcta atctcgattt 3105661 gatcaaatct gatgattttg gcctctcttt tcaccttaat agaaaagttg cctttatcag 3105721 ttgtataagg taaaatcaaa agttctgtgg tttgatcgac atgaaaggcg cgctcaattg 3105781 aatttacttc agcagaaaga cgcttcaaga gtggttcctg ctccgcatct tcatattttt 3105841 ttcgaaattc gacataaaaa tcatatgttt gtcccatttc aacaggcata ggcaaaacat 3105901 gagcatttat ctcagtttta tactctaatg agccagtgtt ttgaagcgga aattcagatt 3105961 ccgttcctga acgtctctct ttcagcttta aaaataactg gtaatcctct aaaaattggt 3106021 gttctgaatc aattgagatt aacaattcaa gacttcctaa attgtttttc aagcttttca 3106081 aaatacattt aatcacagtg ttttcaatca ttactttttt ctgctcctct gtataaaagc 3106141 tctttccttt ttgcttcctt ttattagtgt caactactaa ggacattaac tctcttttat 3106201 ttccgtgacc ctccaagaga aattgccttt aactgttgta tagggctcta ctctatagcc 3106261 attattagta tctatactgt ttcctgacaa ttttgtttct tcactcgaaa gtcttcgcat 3106321 tgttttaata tggccatttg cattgaaaac aatataaaaa tcaataactt gggttttatt 3106381 agcagctatc ttttcaatat ttacatcttt ttcgagatca attacaaaca gttgatcatt 3106441 ttgtaagttt gttgaaataa tttcagcctt attctttctg tccaagccca ctaaacgtat 3106501 ttttttaata tcattatgat caaaattctc aatgtcaatt tctattttag ttttatcaaa 3106561 atcctcagta taggaactaa tagaaggatc tttttttcca acctttttag agaacttctc 3106621 tctttctatt cgcacctcaa tcatctgatt aagagcaaaa gcccaatttt caatatagtt 3106681 gggtcttgaa tatttttcag ccattttaaa agcttgttct gaaaattttt gatgagtact 3106741 ttcatctttc atcaaagaga taatagcttg acccaatttc tctatattat actgttcaat 3106801 gacatatcca tttgctccgt cagtaactaa gctccttgct ccgtaatcat aatcgtatgt 3106861 tacaactgga catccattgc tcagtgcctc catatttgat agaccgaacc cttcaaaatg 3106921 agaggttgaa atggttagcc aagctttttg aaactctgag tcagggttat ccgtatagcc 3106981 tttcaaaaag acattgttct gcagtttggt atcttcaatt tcttttttta ttttttcgaa 3107041 atcttcaccc gatccgaata tatcaagttt tgcttcagga atttctttca cgactaaact 3107101 aaatgctttt actgcatgta tcagattttt catagatgca agtcttgaaa taatgacagc 3107161 tttgtatttt tcactcggca cattcaatac agcgggatca agaggcttat caattgtatg 3107221 cggagtaaag aaaaacgtct cttgttcccc tgaaatcaat ttaaaatctt ctagctgctc 3107281 ctcagttata aaaaagacag catccaaatt atacatctga ctaaatactt ctttatagcg 3107341 acccttaatt tgatatttat tgctgccgta atgcttgtta tgaataattg ctccataata 3107401 ggaagaaggt gattttttca ctttaaagac atgtttgtct tgcggtctgc tgtccactaa 3107461 aaacaactta ggtttatcat tttgtttttg cagatattct atccaatatt gacgcagttc 3107521 cgattcatct tttactttta tctcaccctc aagggagtac caaataatat gagataattg 3107581 aacatctttt tcttcattgt tccatacata gagtttgtct aaatatactt gattttggtc 3107641 attaatatat tcctgcagat acatcttgtt tagctgcaca tcataatgag taacgagaac 3107701 taagtttccg ttcttcgtat attcctctct ctttatgagc tggtttttat cattccaata 3107761 gtcgacgtac cggatagttt ctccatctcc gtagtaaact acagacattt cattgttctt 3107821 cttaccaaac aatctcaaca gagtttttgc aaatttcccc attccaactt gcttttttat 3107881 ctggtcaagg cctatccttt cttcgtatga tcttttccca tttgttctaa cacttaaaaa 3107941 atcatcgaat agattaataa cacttgtgaa ttttttatca atcttaccgt tgctgtacaa 3108001 ttcatcaatt tttgaagaca actctaaatc aaaacgaaac gttaagaaaa aggtgttttg 3108061 gttacactct tctccaaata attttgaacg caataataat gatttcgtca gaccgccata 3108121 attacttggc agtccaccag agataaaata ataatccatg tcaggaattt gttttatatt 3108181 agattcactc accgcatgta aagacaattt tttactccct ttcggcatct agaatatatg 3108241 atcattgaaa tttatatcta cccggatact ttagtcacaa aaatcaatgt aagcatcaaa 3108301 aagtacttct tatttcaata agaagtactt taattagata ttgaaccaat gatatcagga 3108361 tcctaaatta taaaccagca atttcctctt tgatctttgt tgtagagatg ccttctgttc 3108421 ttgggaggta aacaacctca cactgatctt tgagaaagtc aaatttacct tcccagtcat 3108481 cccccataac aaaaacatca atattatgat caataatatc ttgctttttt tgctcccaat 3108541 tcttttcagg aattacttcg tccacatatc gaatggtttc taaaattaat ttacggtgct 3108601 catagctgtg ataagctttt ttttgctttt gtaaattgaa ttcatccgtt gaaatagcaa 3108661 caactaaata atcaccaagc tgctttgcac gctcaagcaa tttaatgtga ccccaatgca 3108721 gtaaatcaaa agttccatat gtgataactt ttttcattta aagaaacgct ccttcctaat 3108781 gttaaacact attaaaaaca ctactgacgt tagcgattaa attctaaaaa cctgtttgta 3108841 ttccttatat cgacatattt ctcgtatgtc ttcactgatc attaattata gcataccgcc 3108901 taaaaaaggt taagtactca tgaggagaaa aacattccaa aatatgtaat tacactcaga 3108961 ctccattggc accaaggtct gttgttcatt cgttcattca attgtaaaat tggaaacata 3109021 tttaaattta atgtaaagat aatgttaatc ctttgttgaa gatttatgtt aaaatataag 3109081 gtagcttgat tttgctttta gaaactctcg gtttttaact atataaatag aatcttaaag 3109141 gaaggaggag ccagacatgc aaacagagac tattcacaat attccttatg ttaacagtaa 3109201 cttaacatca tttatcgatt acctagagaa acattatatt gatcaaaaga ttggtgctgt 3109261 catttccaca gtcaaccctg aaattgcatt tgcagctatt aaagatcggg actactttga 3109321 tgtactatct tcttcaaact tcattttgcc tgatgggatc ggtgtagtca tgatgtcacg 3109381 tttgactaac aacaggcttc agtcccgaat cgcaggttac gatgttttta aagaacttct 3109441 gggcgttgct aacaaaaaga aaaaacgcat atttctgtac ggtgcgaaga aagatgttat 3109501 aaaaggtgtt gtatccaaaa tttcttctga atacccaaac attaaaatcg caggttattc 3109561 agacggttat gttcaagatc gcaccctagt ggcaaaacaa attgcaagag caaatcctga 3109621 catggtattc gtagctttag ggtatcctca tcaagagaaa ttcattcata actacagaca 3109681 cttgttccct aaagccgtat ctataggtct aggaggaagc tttgatgtat ttagcggtaa 3109741 tgtcaaacgg gccccttcct ggatgatacg tttaaattta gaatggttct accggttaat 3109801 cttgaatcca tggcgatgga aaagaatgct tagcatccca aaatatgctt taacggtttt 3109861 aaaagaagaa aaaaacaaaa aaactttcta tccaaagcct gaaaaagatc atacaaaaca 3109921 gatttaaaaa caaaactttc aaataaatgg atgataaaaa tgaaaataag atcactactg 3109981 gcgaattgct atttgtattt tttatcagca atcgcctttt ttctgcaatg ggtgaaacct 3110041 gaaagcaaag tgaccctcct gatctcattc gaagcaaacg caaaagcgat tcttgaggaa 3110101 tatgaacaag gacaatactc ttataaactt aacatcctgt atacccagca ggcctctgct 3110161 attgccgaga gcttcccgaa tgtagatgca tatttattac aagaaaaaaa ccctatccat 3110221 ctcattaaag ctgtatacct aatgtttaac agtaaagtga tcataacaga taattacttt 3110281 ctattaacaa gtgtgttaaa taagcggaag caaacgaaat gtatccaagt atggcacgca 3110341 aatggctcac tcaaaaaatt tggtttggaa gacattacaa acatgcaacg gacgaaaact 3110401 gatattaaaa ggttccaaaa agtatacagt tcgtatgatt atttaactgt tggctcagaa 3110461 gagatggcaa atatcttcaa gaaatcattt ggaataaagg ataaccaatt attaaaaata 3110521 ggtgtacctt taacagaccc ttattaccga gaaaacaaga aaaaaatttc agatactcta 3110581 aacatacaaa gaaaaaaaat aatcctctat gcaccgacgt ttagagatta taatatgcaa 3110641 tcaattcaat tgccttttac agaagaacaa ttaattcatc agttaaaaga agaatatgtt 3110701 ttatttgtta agctgcatcc cgccattcag aacaatattg atattaaata ttccagtgat 3110761 tatattaaag atgtttctaa ctatgccttg tttgatctac tcatggctgc agacatatta 3110821 atcactgact attcttctgt tccctttgaa ttttcgattt taaataaacc cattcttttt 3110881 tatacttacg atttaaaact ttatcaacag aagcggggat tggttgataa ttatctttcc 3110941 ataatacctg gaagagcctg ctatgacagt gaatcattaa taaatgaaat tcaaacccca 3111001 tttaattatt ccaaaataaa agttttttcc gatagatgga ataagtattc tgatgggaat 3111061 tcaagccaaa atttattgaa tttcatcgaa aatttaataa gctaaatgat gacacttgtt 3111121 caaaacagaa caagtgttct tttttctatt gaataccgaa cgtatgtttg ctttaatgta 3111181 attagttgct tatggcagca aataataata gaggtggtaa atttatgaga aaaaaagaac 3111241 tgtttgattt caccaacatc acgccaaaat tatttactga actacgtgta gcagacaaaa 3111301 ccgtacttca atcattcaat ttcgatgaga aaaaccacca aatttataca acccaagtcg 3111361 caagtggatt aggaaaagac aacacccaaa gctatcgcat aactcgtcta tctcttgaag 3111421 gtttacaatt agacagcatg ctgttgaaac atggaggtca tggtacaaat attggaattg 3111481 aaaaccgtaa tggcaccatt tatatttggt ctctatacga taaaccaaac gaaacagata 3111541 aaagtgaatt agtttgtttc ccatataaag caggcgcgac tttagatgaa aattctaaag 3111601 aacttcagcg attctcgaat atgcctttcg atcatagggt tacacctgct cttgatatga 3111661 agaatagaca gttggcaatt agacaatacg atacaaaaaa taataataat aaacagtggg 3111721 tgacaatctt taacctggac gatgcaatag caaataaaaa caatcctctt tatactatta 3111781 acattcctga cgaacttcat tatttacaag gtttcttttt agatgacggt tatttatatt 3111841 ggtatacagg agatacaaac agcaaaagct atccgaatct cataactgta tttgattccg 3111901 ataataaaat agtgctgcaa aaagaaatta ctgttggcaa agacttgtcc accagatatg 3111961 agaataactt ccgtgaaccg gaagggatct gtatgtacac caatcctgaa actggggcaa 3112021 aatcattaat ggtgggaatt acaagtggaa aagaaggaaa tcgtataagc agaatttatg 3112081 cataccattc ttatgaaaac ttcatgaatc atgtacctat gcttcgatcc cctttattaa 3112141 aaaccgtggg gcaccaagat acacctccag aaagatttca accatttatt caaaccttca 3112201 ttttagagta taatgctcaa aacaaaaaat ggatggttcc gacttcaggt tatttaccat 3112261 cttacacatc aaatttagtc cgaaatatta ctatcaatgc agatggaaac ttgcaagtca 3112321 cattaaatga acgctatatt agtttactgc atcaatcgat agaaggagat ttccgcttaa 3112381 aacaaaagga tatccgaatg ggatcctggt attttgccgg cggagaaaaa tcaaatgtgc 3112441 ttgaaatagg ttttatgaaa gggagtacaa aaatcagacc cgatgatgca gccatctcaa 3112501 atgcttcaag aatgagtatt tttatgattg ttgcggacaa gattgaggtg tgataatcaa 3112561 ataggctgta gctatttaat agctacagcc tatttgcaac tttctaagtt ttttatcgat 3112621 attccggaac atcggcctac tttatagacc agcttctttc ggggcaatat gcataaagaa 3112681 aagactccag agattggagt ctttttcttt tattgcaccc gtatacttcc tgcgtattta 3112741 tccttccaat atgtgctcgt gttcatattg gtaatggtca cgccgtttga taatgtgaca 3112801 tgaacaactt gtccgtttcc gatatagatg gagggattta agcttgttga ttgaaagaac 3112861 acaatgtctc ccggcttcag gtccgccttc tcaatcttag ttccggcatt gtactggctt 3112921 gttgcgtatc gaggcaggga aataccggct gctttctggt atacatattg gacaaatcca 3112981 gctgtatcaa atcccgtctc aggtgttact ccgccctgtt tgtaaggcac ttctccgaca 3113041 taaagcgtcg cttcggaaac aatcggattt tctttcggga ttgtcaggtt gtcaaatcgg 3113101 cgaatacccg tcatcttcga tttccagtaa tcctctgaca aataggaaat ggttactttt 3113161 tctgaccggc ttgcctgaat gaacctgcct gcgcccgcat aaatgcctgc atgtgaaatt 3113221 cccgttttat acgtattgct gaaatagacg acatcaccag gctttatgtt ctgaggggct 3113281 accttctcgc ccactgccca ctgctgttcg gctgatcgcg gtagataaat gccgagtgcc 3113341 tgttgaaaca catattgcac aagccccgag caatcaaagc cctctgacgg cgtgcttccg 3113401 ccaaacacat atgggacacc gatatatttt tcggcctcct gaacgacagg aacatcagcc 3113461 gttgccggat cggcagcgat tcgtctcgcc ccgatataag ttccgctcca atagctgctt 3113521 tttttgtaat tggtgatgat aacccctttt gactgtgtac tgtgaaccat ttggccgtct 3113581 ccgatataaa gggcgtcatg tgtcggaaca gtgccggtgc ttccctcttt cttgaaaaac 3113641 aaaatatcac ccggcttcag gttttccggt tttacagctg ttccgatttt atactggtcg 3113701 tttacagatc tcggcagatg aatatcagcc ttactgaaca catattgtat caatcctgat 3113761 ggatcgaaac cctctttcgg cgtttccccg ccatatttat actgatatcc aagcaggttt 3113821 tttgcttcgc tgacaatcaa ttctgatgat gtatcagctt ccgcaatctc cgcttttgtc 3113881 ataattggaa ccaaaaaaca aatgataacc gccacaagca aaaacttctt ccagtttgcc 3113941 agtgtgttca cttttattat ctcctcctct ttttgcagtt ttaacatcgg tatttttttg 3114001 aatatgttaa gagacttttt aatattttta cagaatgaat atgctgggca aataaaaaga 3114061 gagtgtctca tcagacactc tcttttttga attatttatt ggcgtttacc ggttcttcct 3114121 gctgctggat tttattcatt tccatatcaa tcttctgttt ttcctgatct gtcagctgat 3114181 cattgaattt aaaagctgac ataaacatga acacgatggc tacggcaaca aacggccaga 3114241 tggctttgac aaatttcatc tttatcactc cgattattta gattttagtt tgtcactatg 3114301 atcaatatca aacgtcagtt ttccgtcttc tactttccaa gcgaaattag agtctttcgt 3114361 cagttcgcga ataatggttt tctgtttaag gctgtctttt ttcacaggcg caggtgtcgc 3114421 ttcatggata tcgatcggtg tcacttcaaa gcgtcctgtt ccatttttct tcaggtgata 3114481 ctgaaccagt gcactgtctc ttgttctcgt ccagccttgg tcaaagacaa agttgccgag 3114541 gctgtagaaa atgacggttc cgttatatac ttcaatcggt tctaagacgt gcgggtgatg 3114601 gccgacgatg atgtcagctc ccgcatcaga catggctctt gcaagctggc gctggcggtc 3114661 atttggatca ttgtcatact cttgtcccca gtgtgactgc acaacaacaa tgtccgcatg 3114721 ttttttcgct tctgaaatca tagggatgaa gatttcagga tctgcgggca gcacgcccgg 3114781 cgtattcttt ttagccgcga aacctttccc ggacacatcg gtaaagccaa gcgtcgcaat 3114841 cgttaccccg ttgactttct ggtacgaaat tttctttttc gcatcactta agctgtatcc 3114901 cgctccaacg atatcaagat tttgcttcgc aaattctcca agcgtatctt tcatgccctg 3114961 aacgccgtaa tccattgcgt ggttgttggc gctgttgaga accgtgaaat tcatatcctt 3115021 caagactttc actgattcct tattcgtctg cagatgaatc tctttatctg cttgtttata 3115081 attcttttga taggttaccg ggttttcaaa gtttcctgct acataatccg aggctctaaa 3115141 gatcggttca acatattgaa aaatactgtc tgcccctttt tgctccgtta ctttttcaac 3115201 atagcgtccc atcataatat cgcctacaaa tgaggctgag agtacgtcgt cagaatacgt 3115261 tttgaccttc ggcgtttccg cttttcccgc ccacatgaaa gcgaacataa ggacaaaaac 3115321 gatcggaatg gcaataaata cgtgcttatt ggttttcttt ttttgctgtt ttgtcagctt 3115381 tagcagcttt tcatgaaagc tcagttcttt tttcatcgtt tgacacacct tacattaaat 3115441 taagtagtaa acaaacatga tagcaaaggt cgctccgctc aatagcagcg tgcttccgaa 3115501 cgtaatggtt aaaccttgtt tctgaatggt attggcaatt aaacctggca cgatgatgcc 3115561 gattcctcga aattctgcga tttcaaatgg tacaatcggg tatagaaaat caaacgcgat 3115621 ttttaggacg atccctgtta tcagcatggc agcgaatttt ctgcgtccgt acaaaatcat 3115681 aaatttggat aaaccgtatt tcacaatgac atacgtgagc aagctcacta gcaaaacaag 3115741 taaaataaag accggctgat taaacacaag tcctaaatat cccggtacaa caagtcctgc 3115801 cggcacgatc cctgtttttt ccgcaaaaat taaactgagt agtacaccta aaattagtgc 3115861 gatgtataaa tctgatccga acatgtctgc atttccccct agcttacgag ctgctttacc 3115921 ttgtattcgt ggattttttc aattaaaggc tctgcggcac catgaatatt gccgacgcca 3115981 tatatgacac ggttgtgcat tcttttcttt aacaattcca taatttcatc tgttgactta 3116041 tactctagat catgcagttt gtctgcagga attttgcctt cttcgtaggc ttttacgatc 3116101 ggttctgttg tttcaccgat taagatcagt tcacttgctt caatataagg caatacgtca 3116161 tttgcgaatt gctgtgtccg atcgacacgg tctgcgcggc agttcatgat gatgatcgga 3116221 tcatcggtcg ggtaaccgat ttcttttaca cgtttccata tattcaaagt agaagaagcg 3116281 tcgtttgcgg caaacccatt aacaaagtgc ccaggctcgc tcggactgat cagcggaaga 3116341 attctcattg ctcccggatc tggcggcgca ttcagcattc ccttaaatgc tgtttcttcg 3116401 tcaatgccga gtgcttgagc cacacccagc gccagagaag cgttatcagg gaataccatg 3116461 tattcaaatt tacgtaaata ctcatctgta atttttgagt tatcagcaat gatgactttt 3116521 gtgtttcgtt cttttgcttt ttgtttaaag aactcggtat attcactatc tgtaatgaca 3116581 agatggccat tataaggaat tgtagcagta aacgcttctg caatttcatc aagcgtcggc 3116641 cccatgacat ccatatggtc ttccaaaaca ttcacaatga cgccgatatt ggcctgcaga 3116701 agttcttcct gaaagatgat ttgataatct gggttaacag ccatgcattc actgacaatc 3116761 gcgttagccc ctctttctac tgtttctctc atgacttctt tttgctctcc gatattcggc 3116821 ccctgaggtt tccgtttaat cggcttttcc tccggtgtgt cccagtaaat cattcttgca 3116881 tctgttcctg ttgtttttcc aacagtcttg taaccggctt ctattaatat tccggttgtc 3116941 agccttgtca cagtcgattt tccgcggatg ccgttaatat tcacccgaac agggagggca 3117001 tcaatgtttt tctgatgtcg tcgtttttct aatattccga tgaccagtat gacagcacag 3117061 gctataatga gtaaccacat tgcttttcga catctccttc tatattgttg taaattcatt 3117121 catcagtata tagaatcact atgaattctc aatcggcatt atgtaacata atcttcccta 3117181 atcgactaag ccaaacttct cttttgaaag agattttata cctacaaact gttttctatt 3117241 tttggaaaac agcaggactt ataccttatc actttttaaa aaaatcaaag agaatgcgct 3117301 ttcatttttc tcctgatatc cttctggacg tatagtcaca ccctgctgtt tgtatttaat 3117361 atgcatttca aatcaatctt tttttcagcc tttgttatca agcatttcct gctatcatgc 3117421 gtgtttccgg ttcttatgaa cacaaaataa ttttatcctg tttcttaagg acaaggtcat 3117481 aatgtcatcc tttctgcatg gaataagcaa tatgaggccc attccaaaat gactaaggag 3117541 gttcgagatg aaaacgctaa acatacgagt ccgaattctc taacataatt aaacattttc 3117601 tgggatgata gtcttttctg tttctcccca tttacaggtc taaacgcatg actttgaaac 3117661 aattttaata aaacttaata tttgttcaag aaatcttcat ccatatttgt gaagactttg 3117721 tcaaaaaaag agtgaaaacc ttaaattttt caattatata tacaatttac aattagattt 3117781 cttttgatat ttttattgct aacttcggat tgttcatgat aatctatcta tgtaaacggt 3117841 tacataaaca aggaggagct gttttggcta caattaaaga tgtcgccgga gcggcgggcg 3117901 tttcagttgc gacggtttcc cgcaacctga atgataacgg ctatgtacac gaagaaacgc 3117961 gaacgcgtgt catagcggcg atggcgaagc tgaactatta cccgaatgaa gtcgccagat 3118021 ctctatataa aagagaatcc cgactgatcg gacttttgct cccggatatc acaaaccctt 3118081 tcttccccca gcttgcccgc ggtgcggagg atgaattgaa ccgggaaggc tatcgcctta 3118141 ttttcggcaa cagtgacgag gaattgaaaa aagaacttga ataccttcaa acctttaagc 3118201 aaaatcatgt cgcaggcatt attgccgcaa cgaattaccc ggatctcgag gaatacagcg 3118261 gcatgaatta tccagttgtt tttctggaca gaacgcttga aggggctcct tctgtgtcca 3118321 gtgacggcta tacaggagta aagttagccg cccaggctat cattcacgga aaaagccagc 3118381 gcattacgct cttgagagga cccgctcacc tgccgaccgc tcaagaccga tttaacggcg 3118441 ctttggaaat cttaaagcag gctgaagttg attttcaggt cattgagaca gcttcatttt 3118501 caattaaaga tgcacaatcg atggcgaagg agctgtttgc ctcttatcca gcgacagatg 3118561 gtgtgatcgc gagtaatgat attcaagccg ctgccgtttt acatgaagca ttgcggcgcg 3118621 gaaaaaacgt gccggaggac attcaaatta tcggctatga tgacattccg caaagcggac 3118681 ttctgttccc gccactttct acaattaaac agcccgcata tgatatgggg aaagaagctg 3118741 ccaaactgct tttgggtatc attaaaaaac agccgctggc agaaacggca attcaaatgc 3118801 ctgtcaccta tataggaaga aagacgacaa gaaaggaaga ttaagatgcg taatatttgt 3118861 gtgattggta gctgttctat ggatttagtg gtcacctcgg acaaacgccc aaaagccggt 3118921 gaaacggttc ttggcacgtc atttcagact gtgccgggcg gcaaaggagc aaatcaggcc 3118981 gttgccgcag ccagacttgg ggcgcaagtg tttatggtcg gcaaagttgg agacgatcat 3119041 tatggaacag ctattttgaa taatctcaaa gctaacggcg ttcgcactga ttatatggaa 3119101 ccggttacac atacggaaag cggaaccgct catattgtgc ttgctgaagg cgacaacagc 3119161 attgtcgttg tcaaaggcgc gaacgatgac atcaccccag cgtatgcgtt aaacgcgctc 3119221 gaacagattg aaaaggtcga tatggtgctg attcagcagg aaatcccaga agaaacggtt 3119281 gatgaggtgt gcaaatactg ccattctcac gatatcccga tcatactaaa cccagcaccg 3119341 gcccgcccgc tcaagcagga aacaattgat cacgctacct atctgacgcc gaatgaacac 3119401 gaggcttcga ttttattccc tgagcttacc atttccgaag ctctggcgct ttatccggca 3119461 aagctcttta ttacggaagg aaaacaaggc gtccgctatt cggctggcag caaagaggtg 3119521 ctcatcccgt ccttccctgt agaacccgtt gatacaaccg gagccggtga tacgtttaac 3119581 gcagcatttg ccgtggccct ggctgaggga aaagacattg aagccgcatt gcggtttgcc 3119641 aatcgtgccg cttccctttc tgtctgctcc ttcggtgccc aaggcggaat gccgacaaga 3119701 aatgaagtag aggagctgct gtcatgaaaa aacacggtat actgaacagc catcttgcca 3119761 agattttagc cgaccttggc cacactgata aaattgtcat cgcggatgcc ggactgccgg 3119821 ttcctgacgg cgttttgaaa attgatcttt cactgaagcc gggccttccg gctttccaag 3119881 atacagcggc agtactggct gaggaaatgg cggtcgaaaa agtcattgct gcagctgaaa 3119941 taaaagcatc caatcaggag aatgcgaaat ttctagaaaa tcttttctct gaacaagaga 3120001 ttgaatacct ttctcacgag gagtttaagc tgctgacaaa agatgcaaag gcagtcataa 3120061 gaacaggaga attcacacca tatgccaact gcatcctgca ggcaggtgta cttttctaga 3120121 aaggaagatg aaacatgcag attgaaatga aagacattca taaaacattc ggaaaaaatc 3120181 aggtgctgtc aggcgtttcc tttcagctca tgcctggcga ggttcacgca ttaatgggag 3120241 aaaacggcgc cggcaagtcc acgcttatga acattttgac aggcctgcac aaagcagata 3120301 aaggtcaaat cagcataaac ggaaacgaaa cgtatttttc caatccgaaa gaagcggaac 3120361 agcatggaat agcctttatc catcaggaat tgaatatctg gccggaaatg accgttcttg 3120421 agaatctatt tatcggtaaa gagatatcct ccaagctggg cgttttacaa acaagaaaaa 3120481 tgaaagcgct agcaaaagag caatttgaca aactttccgt ctctctttct cttgatcaag 3120541 aagccggcga atgttccgtc ggacagcagc aaatgatcga aattgcaaaa gcgcttatga 3120601 caaatgccga ggtaatcatt atggatgaac cgaccgcagc gttgactgaa cgtgaaatca 3120661 gcaagctctt tgaggtcatt acagcgttaa aaaagaacgg cgtctccatt gtctatattt 3120721 cgcatcgcat ggaagaaatt tttgcgattt gcgacagaat taccatcatg cgtgacggaa 3120781 aaacggtaga tacaacaaac atctcagaaa ctgattttga tgaagtcgtc aaaaaaatgg 3120841 tcggacggga gctgactgaa cgatatccaa aacgcactcc ttctctcggt gacaaagtat 3120901 tcgaggtgaa aaatgcttcc gtaaaaggga gttttgagga cgtcagcttt tatgtgcgtt 3120961 ccggtgagat cgtcggtgtt tcaggattaa tgggagccgg ccggacagaa atgatgagag 3121021 cgctgttcgg cgttgacagg ctggacacgg gtgagatatg gatcgctggg aaaaaaacgg 3121081 ctattaagaa cccgcaggaa gccgtgaaaa aaggtctcgg ctttattaca gagaatcgca 3121141 aggatgaagg gctcctgctc gacacctcga tccgcgaaaa tattgccctg cccaatctgt 3121201 ccagcttctc accaaagggt ctcattgatc ataagcggga ggctgaattt gtcgatctgt 3121261 taatcaagcg cctcactatc aaaacagcat caccggaaac gcacgcacgc catttatcag 3121321 gaggaaacca gcaaaaagtg gtgatagcca agtggatcgg catcggaccg aaagtgctta 3121381 tcttggatga gccaaccaga ggtgtggatg ttggcgccaa acgagagatt tatacgctga 3121441 tgaatgagct gaccgaacgc ggtgtcgcta tcatcatggt gtcatcagag cttcctgaaa 3121501 ttctgggaat gagcgatcgg attatcgttg tccatgaagg cagaatcagc ggcgaaatcc 3121561 atgcgcgaga agcaacacaa gaacgaatta tgacacttgc cacgggaggg cggtaatatg 3121621 aaaacggaac aactgcaaac agaacaaaaa cggattcact tcgacggagt catgcaaaaa 3121681 ctcggcccgt ttcttggttt atttattctc gttatcattg tatctatttt aaatcccagc 3121741 tttcttgaac cgctgaatat tttaaacctg cttcgccagg tcgccattaa cggattaatc 3121801 gcgttcggga tgacctttgt tattttgaca ggcggcattg atctttctgt tggcgctatt 3121861 cttgccctgt ccagtgcttt agttgcgggg atgattgtgt ccggtgtcga tccggttctc 3121921 gcgatcatcc ttggctgtat cattggtgcc gtactaggca tgatcaacgg attattgatt 3121981 actaaaggaa aaatggcgcc ctttatcgcc acgcttgcga ccatgactgt gtttcgcgga 3122041 ctgacgctag tgtatacaga tggaaatccg attaccggac ttggcacaaa ctacggtttt 3122101 cagatgttcg gacgcggtta ctttttaggc attcctgtac cggcaattac gatggttctt 3122161 gcctttgtca tcctttgggt gcttcttcat aaaacaccat tcggacgccg aacgtacgct 3122221 atcggcggca acgaaaaagc cgcgctcatt tcaggcatca aagtgacgcg cgtgaaagtg 3122281 atgatctatt ctttagccgg gcttttatcc gctcttgcag gtgccatatt gacttcccgc 3122341 ctgcattcgg cccagccgac tgcgggagaa tcgtacgaac ttgatgctat cgcggcagtc 3122401 gtcttaggag ggacaagtct ttccggcggc cgaggacgca ttgtcggcac gttaatcggg 3122461 gtgctgatca tcggcacact taataacgga cttaatctgc ttggcgtctc atcattttat 3122521 cagctggttg tcaaagggat tgttatctta attgcggtat tgttagaccg caagaagtca 3122581 gcttaggagg gttttacatg aaaaaggctg tatccgtcat tttaacgtta tcattatttt 3122641 tgttaaccgc ctgttcgctt gagcctcccc aatgggcaaa gccatcaaac tcggggaaca 3122701 aaaaggaatt caccattggc ttgtccgtct caacgcttaa taatcctttt tttgtctcat 3122761 taaaaaaggg tatcgaaaaa gaagctaaaa aacggggaat gaaagtcatc attgttgatg 3122821 cacaaaatga ttcatcgaaa cagacgagtg acgtggaaga tttaattcag caaggtgttg 3122881 atgcattatt aatcaacccg actgattctt cggcgatctc aacggcagta gaatctgcaa 3122941 acgcagtcgg tgtgcccgtc gtaacaatcg atcgatctgc ggaacaagga aaagttgaaa 3123001 ccctcgttgc ttccgataat gtaaaaggcg gtgaaatggc cgcggcgttt attgccgaca 3123061 aacttggaaa aggagcaaag gtggcagagc ttgaaggcgt ccccggcgca tctgccacac 3123121 gggaacgcgg ctcaggattc cataacatcg cagaccaaaa gctccaagtt gtcacaaaac 3123181 aatcagctga ctttgaccgc acgaaaggcc tgactgtcat ggaaaacctg ctgcagggac 3123241 atcctgatat ccaagctgtt tttgctcaca acgatgaaat ggcgctcggt gctctcgagg 3123301 caattaacag ctcggggaaa gacatattgg tgatcggttt tgacggcaat aaagatgcgc 3123361 tcgcttccat taaagacaga aagctgtcag ccaccgtcgc tcagcagcct gaattaatcg 3123421 gtaaattggc tacagaagca gcagatgata ttttgcacgg gaaaaaagtg caaaaaacaa 3123481 tatccgcgcc tctcaaacta gaaacacaaa aataattgtc tgatgtttag gaacctgcga 3123541 taacgtgaat agagatatag aatgaattat ttctcttacg tgaggagagg aacggcatga 3123601 acaaaccaac aaaactattt tcaacattag cacttgcggc tggaatgact gcggcggctg 3123661 ctggcggcgc tggcacgatc catgctcaac agccagaaac aacggtaagc attgatgatt 3123721 tatacagtta tccgattgat tcttatttgg tatcagcaga ggctctaaat gtcagaacga 3123781 agccttccgc atcaagccag aaagccgata cgctgcactt aggagatagc ctaaagctga 3123841 tttccttctc aaatgctgac tgggcaaagg ttaagtataa aaatggaaaa acaggatttg 3123901 tatccactca ttacattgtt aaagcagcga caacggtaaa aaccaaaaca aaaacaaaag 3123961 tgtatacatc cgctgacgga aagagcatta agactcttcc agcagacaca agcgtttctt 3124021 ttttaggctg gagtaaaacg aataaaggcg gttttgattt tgattgggta ttcgttgatt 3124081 acggcggtac gacaggttat atgaaaacaa aggatttaca catgacaaaa taactgagag 3124141 ggattccgca taaatgcgga atccctttta ttatgaattg atttgtcaca ttcccaagat 3124201 atttctcagg aaatattgtc gtatgctgtg tcgaaacctt acatgatcat cgacattttt 3124261 gttcacgcta aaaagcggag gtgtaaatat ggatcaattt gaagcagcat atgaatcgta 3124321 taaagcccgg caaacaactg ccgatcaaga aaatgttcca tctggaaaag aagaaattat 3124381 tgcggttaga agaaatgagg aagacaatat tatcgcagtg aaaaccaata caggaagaga 3124441 gctcgactac cctactgcgc tgtcagaagc aaaatcagga aaactcgctc atgttgatgt 3124501 cttccataaa tacgggcgtg acattttgcg aagtgaaccg gacggcatca aggaaaataa 3124561 cctgtctgag ctgccggatt tttaaacaaa tacagccctg ccgtatgttg gacagggctg 3124621 tattttaaac aaaaggctgc tggatgtatt cggctaaccg ttttgcactg tgagaaatat 3124681 cctctgcagc tgcataattc acgccataga acacatatgg aggcagatac ttcatgccga 3124741 tcagattact cgtggcctga aatggtttca atagctcact gatcgagtaa tgatttgctc 3124801 cgcccgcttg atatttttcc gcttcgctcc ctgttgatac agccagcatc agctccttgc 3124861 catgcaaggc atttccttct gaaccaaaag cccagccata agtcagcaca agatcctgcc 3124921 attttttcaa gagcggcgga gagctgtacc aatatagcgg gaattgaaag acaatccgat 3124981 cgtattcctc gcacagctgc tgttccttcg caacatctat cgcttcatcc gggtattcct 3125041 tataaagatc ccgtactgtg atattgtcat gtttactcaa ttcctcagcc cacgccttat 3125101 taacaactga ggtctccata tgaggatgca ctgccaaaac caatattttc atcagaccac 3125161 acctttactg ttttgatgtt attttatcta aaatcaggaa aagagccaaa taaaaagaaa 3125221 gccctgctaa aaggggcttt ctttttttct tttattcagg gcttccttca gttgtttcga 3125281 tatctttcgc aaaatcaggg ttatccagat tcgcattaaa gaaatccgct gtgttcggaa 3125341 gtctgagatt catgttcatt ttttgagaaa tcgtaaccgt gcaatcctca agcacatagt 3125401 caaaaacgtg tccgcctgaa ttgcgtcctt cgtcaatgaa gtgcaggtga tagccagaaa 3125461 cggcgattcc gtttgcataa gctggtgtca agaaacctac aatcgttcct ctcacgttgt 3125521 cgaagttgaa aatcggctgt gttttgaccg cttcaaccat tggcacgtaa ggtttttctt 3125581 gaagttctac tgttcttgtc tgcacctttt taaacaatcc gtcaatgcga attgcataaa 3125641 ataagtttct gcttggcagc atgctgttga tctctttttc aaagtcttcg cgtgtcattt 3125701 tcgcatcaat tttgtgcgtc atgtccggtg taaagaacgt aaatgaacag aacggtgaac 3125761 ggtctccatt ttggaccggt gtcgcggttc cgtctgagcg aagacggtaa aattcgccgt 3125821 caaacccaat cagctctccg tcaagcttgt taaaggttcc gataccgaag tctccatatt 3125881 tcggaatctc tgacagttca aaatctccgt catatactcc gtctaataga gaagtcattg 3125941 ttgatacttg ataaatctgg ctcacaggct gatctttttg accacggctg agcacttgaa 3126001 tgttgctttc tcgtttcata tttcccttca ctccttttat ttagtgctgt tcataaaaca 3126061 gtgtcgtgat gcgcagagtg ctagagagct ttcgttttca tgagttcccc gaattctttc 3126121 ggaagcttgt cacttgctaa attaatgtta tcactgtagt caaccgggac atcgatgatg 3126181 acaggacctt cagcgttcat gccttgacgc agaacatctg ccagctggtc tggtgattct 3126241 acgcgcaagc cagttgctcc gaagctttcc gcatatttca cgatatcgat atttccgaaa 3126301 tcgaccgcag atgtacggtt atattttttc aattgctgga atgcaaccat gtcatatgtg 3126361 ctgtcgttcc atacaatgtg tacaattggt gcttttagtc gaactgctgt ctctaattcc 3126421 attgctgaga ataagaaacc gccgtcacca gagacagaaa ccactttttc tcccggtttc 3126481 accaatgaag cgccgattgc ccaaggaagc gcaacgccga gtgtttgcat accgttactg 3126541 atcattaatg ttaacggctc gtagctgcgg aaataacgtg acatccaaat ggcgtgcgaa 3126601 ccgatatcgc aagttactgt aacatgatca tcgactgcat tacgcaactc tttaacgatt 3126661 tcaagagggt gcgctctgtc tgatttccaa tctgcaggca cctgctcacc ttcatgcata 3126721 tattgtttta aatcagaaag gattttctgc tcacgctctg caaattccac tttcacagca 3126781 tcgtgttcga tatgattgat cgtggacgga atgtcaccga tcaattcaag atcaggctgg 3126841 taagcatgat caatgtcagc gataatctcg tctaaatgga taattgtccg gtctccattg 3126901 atattccaga atttcggatc atattcaatc gggtcatagc cgatcgtcag aacaacatct 3126961 gcctgctcta gcagtaaatc gccaggctgg ttgcggaaca aaccgatacg gccaaaatat 3127021 tgatcctcta aatctctaga aagggtaccg gcagcttgat atgtttcaac aaatggaagc 3127081 tgaacctttt tcaaaagctt gcgaaccgct ttaattgctt ccggtcttcc gcctttcatg 3127141 ccgaccaaaa cgacaggaag ttttgctgtt tggatttttg ctatggccgc actgattgca 3127201 tcatctgctg caggaccgag ttttggcgct gcaacagcac gcacgttttt cgtatttgtg 3127261 acttcattca caacatcttg cggaaagctc acaaaagcgg ccccagcctg ccctgctgac 3127321 gctatcctaa atgcatttgt aacagcttcc ggtatatttt ttacatcttg aacttctaca 3127381 ctgtattttg taatcggctg gaatagcgcc gcattatcca aagattgatg tgtccgtttt 3127441 aaacgatctg cacggatcac gtttccagca agcgcaacga cagggtctcc ttcagtgttc 3127501 gctgtcagca ggcctgttgc caagttagag gcacccggtc ctgatgtgac taacacgact 3127561 cccggttttc cagttaaacg gccgactgct tgggccatga atgctgcgtt ttgttcgtgc 3127621 cgggcaacga taatttcagg tcctttatct tgtaaagcgt caaataccgc atcaattttt 3127681 gcacctggaa tgccaaatac atgtgtgaca ccttgctcca ctaagcaatc aacaacaagc 3127741 tccgcccctc tgtttttcac aagggatttt tgttcttttg ttgcttttgt caacaccctc 3127801 actccttatt atgcatttta aacgtaaaat tttaaatatc ttgtgataag tttcactata 3127861 cactctttgg aaattgacct ccaatatcga ttcgccttat gattaatatg taatacgaat 3127921 tattaaccta tggaaaggaa tgcatattga atggagcttc gccatcttca atactttatc 3127981 gcagtagccg aagagcttca tttcggaaag gctgcccggc ggctgaacat gacgcagcct 3128041 cctctcagcc agcagatcaa acagctggag gaagaagtcg gagttacgct tctgaaaagg 3128101 acaaaacgat ttgtcgagct taccgcagca ggagaaatct ttttaaatca ttgccgcatg 3128161 gcattgatgc aaatcggaca aggaattgaa ctggcacagc ggacggcccg cggcgagcaa 3128221 ggccttctcg taatcggttt tgtcggatca gctacatatg aatttctgcc gccgattgtc 3128281 cgggaatatc gtaaaaaatt cccatctgtg aaaatagaac tgcgtgaaat atcctcgtct 3128341 aggcagcagg aggagctact aaagggcaac attgatattg gtatacttca tcctccctta 3128401 cagcatacag ctttacatat cgaaaccgcc caaagcagcc cttgtgtttt agctttgcct 3128461 aagcaacacc cattgacttc taaggaatca attacgattg aggatttaag agatgaacca 3128521 attattactg ttgctaaaga agcatggcct actctataca tggattttat tcagttctgt 3128581 gaacaagcgg gcttcagacc caacattgtc caggaagcca cagaatatca aatggtgatt 3128641 ggtttagtca gtgccggaat tggtatgaca tttgttcctt cctcggccaa aaaattattt 3128701 aatttggatg ttacttatcg aaaaatggac caaatacagc ttaatgcaga atgggttatc 3128761 gcttaccgca aagacaatca taatccgctt ataaagcatt ttattcatat ttcaaattgt 3128821 cagcagacaa gaactaaaga gagtgatgca ggtacatgaa caatacttgc aatctctttt 3128881 ttcttttggg attcttatgg aatttttatt aatttaatat aatcgcttag tacaacttta 3128941 tatcagtata cgtatacata cagtacaaat agttggcaag gacatcagta agcgcaggac 3129001 attagtttga ttttaaaaat gaaagataga gaggtgaagt aaattattga gttcaccggc 3129061 atattcacat tgctcgcttt tttcgtaaca atgattttta ttttctggag accaaaagga 3129121 ctaaatgaag ctatccccgc cacatttggc gctttaatgg ttttattgtg cggaagtgtg 3129181 tcattggcag acttagggga aatcggaaca aaagtcacgg gtgcatcggt tacaatcctt 3129241 gccactatga ttatggccat tgcactagaa agctttggtt tcttttattg ggtggctgca 3129301 aaactgctcc aacaatccaa gggttcaggc atcaagcttt tttggctaac caatttgctc 3129361 tgctttctca tgaccatttt ccttaataat gatgggagca ttttgatcac aactccaatc 3129421 cttttgcttg tactaaaata tttaggttta aaaaaacatc aaaaagcccc atatttatta 3129481 agcggtgttt taatagccac agcctctagc gcaccgattg gcgtaagtaa tattgttaat 3129541 ttaatttctc tcaaaatcat tggaatggat ctatatcttc acaccgccat gatgtttgtc 3129601 cctagtatga tgggactcat ttttatgact tgtctactgt ttatgttctt ttataaacgt 3129661 cttcccaaaa gcctgccaga tataccgggc cattttcagt ctctgcggca tagaaggtac 3129721 catcctcttc attcgccatc agctccttta ccagaacgaa atcaaacaaa aatcatgttg 3129781 tttgtgcttg catttgtttt tctcgtcaga atgagtctat ttgcagcatc atataccggt 3129841 atttctgttc ctctagtcgc tgtcatcgga tcttttatcc tgttgagctg gagatggatt 3129901 tatttcaaaa cctccccaag agacttgtta tataaatcgc cttggcacat ttttatattc 3129961 gcttttacta tgtatgtctt aatttatggt ctgcataata ttggattcac agagttactt 3130021 gtgagttatt ttgaacctgt ggtttctgga agcctcgccc atgcaacttt cgcatcaggt 3130081 atctctactt cagttttttc taatctcttt aacaaccatc cagcgttaat gatcagtact 3130141 tttaccttaa ctgaaatgac cctgaatcct tcaacaacaa aaatcatcta cttggcaaat 3130201 attatcggca gtgatatcgg ttcattatta ttacctatgg gaaccttagc aacgcttatt 3130261 tggatgcata tattaaaaca gcatgatgaa agtatttcat ggggcgaata tataaaaacg 3130321 accattatca tcattccgct gactgttctt tttacgttaa catgtttata tttttggatc 3130381 agttggttat ttctttagca cagtatgaaa cgaaaaactg ccttctgctt ttcaagaggg 3130441 cagttttgta tacactaggg aagatgcatt gtctttagat gatttaactt ccaaatgact 3130501 ggctctccac ttgcgttaat aagctcaatg atattattag agacaccctt taatagtccg 3130561 actttttctg gcacctctcc catatcaaat atgaccaatt caccaatatt ttttttgatc 3130621 tgctcctcaa aattacgcac aagaggaact ttggaaggca cgaccggcaa ttgtgagttg 3130681 tcaagagtat acggtgtttg ttcagttgaa taaggggtaa accattttaa atgatgcata 3130741 gatataaaaa gtattttaaa tacgggtgag aaaaatacaa tataatcgtt taaaacattt 3130801 gtaacatatc catggatcga tcgaccccca gttacataaa cttcaataaa ctggcctttg 3130861 accttgttta atgtatttct atatgaaaaa gcttgagttt ctgcctctat cattggatct 3130921 tccggattga tcaaaaatgg cttctcagta ctggtcacta ttttcgcctt gtttatttga 3130981 tgaagatgca acaagggaat ataaagataa ttgcagccat caaaaataac aaaaatatcc 3131041 tgtccgatat ctatgagggt gccgacaaac cttgtatctc ctgaaatgac aacctcaaca 3131101 tctgtgttaa ggaattgatt caaacctttc acgattctcc tcctttaact gaaaaagggc 3131161 atcactttat ctgatgctcc tccattatct attaaaattt acgtttccag tgatagtcta 3131221 tcgttctgac aatcgtttca tagctataat cttccttttg ttttcctgaa ctttttattg 3131281 aacttgaata gcctggtgat cttgatgatt gataatctga agatcttggt gatcgtttag 3131341 atgattttga tgattgataa tctgaagatt ttaatgatcg tttagatgat tttgaagaac 3131401 tttttgaacg tgacgaacgg ccagatttgg atgattgata atccgaagat tttagtgatc 3131461 gtttagatga ttttgaagaa ctttttgaac gtgacgaacg accagatttg gatgattgat 3131521 catctgaaga ttttagtgat cgtttagatg attttgatga gctatatgat tttgaagaaa 3131581 tgaacgaatt gctgtcctta tcattattgt cttcctggtt ttgttcattt ttttgatcct 3131641 cttttttgta cgaccctttt ggacctaagc tgatgctttt tatgtgaaaa ggatagatgc 3131701 gaagcacctc ttgatttttc actatagtat aatggccgtc ggcattatct acaaggatac 3131761 cctcaatggc ttccggacct ccacgattaa ttgaaaccca tttatgagtc agactcttaa 3131821 aaacctcgct taaatcatca gcttccaaaa ctccaactgg cgtctgctct tctattttca 3131881 aatcaggctc gtgtttactt atacttttga tgtgatggat attaaaatac actaccccat 3131941 cctcatttgt gtttaacgca gcgtaatcat ctcccagcca gaccaatctt ccttttttag 3132001 attccggacc cccttggtta aattgaactg attggtttat taaatgtccg attaagctat 3132061 gaaaatcatc agcatcgagc atttcctcag tctcaattgt tgtggtgcta ttattggtat 3132121 cctcagtaat acttttcaca tgctccaact gataataaat tatttttttt tcagcttgta 3132181 aagctatata atctgatttt acagctgtta attttccttt tttagattcc ggacctccac 3132241 gatatacagt aacaatttta tctttcattg agtgcaaaaa gttataatac gatatttcat 3132301 tatttgaatg atatttcatt ctcctcttgc tcattcaaat tcctcctagt cacttataca 3132361 tagatgataa acatactgca tatatacgtg tcacatttat ttgttgaact aattcaatag 3132421 cctaattgtc gctttttccg cgaataccca ttttcacgca ttcataaaat acttaaatga 3132481 tctttgaggt attgtgaacg gtttttaata tactcgcaga tcacatccgg ctcacggtca 3132541 aaacgctcaa tatcattctt tttatacggg tccatgagga caaacggcct aatccgttca 3132601 tacatcgcca tgattttcgg ttccatatat tctattgtaa aaagagattg gagcgttttt 3132661 tctaacaggc gcttgtagga cttgcgaaac tcggattcat ccaatatccg ggcggttagt 3132721 gtattaaatc cttgaattct tacataatcg gcagccatcc gctctccatg gatatccctg 3132781 ccccaagtcg catcataatc ccaaggaatc acctcaaata atccggtttc cccgcttctg 3132841 tataatgcgt agttgtggac aaacccgtca tagttcgagg tgaatacaat accagcaagc 3132901 cagcgcaaat acttatcgac atccacgtgt tttgtcactt ctgacttaaa ctgagcttta 3132961 gggaccgtat taattttaaa aatcatatct tgtaaataaa aatcatcttc ctcagtccct 3133021 gttttctttt catatccaag ctccagcgat gttttcgttt ccctttctaa atcgctcatc 3133081 agagaaaagt tggcatcatc atccaccgca taaaaaatcg cgccatcagc cagcttcctt 3133141 ttcgccaaat aatattcatc tacggattca agttcaagat aaaccccttc attcttccca 3133201 ttcatcttta caaacgcaaa ctctgccttt ggagacagtg tccctagctc cgagaaaaaa 3133261 tccagagaca atttgtttct catcaaggaa gggtctttat actccgcatt taagtgaatc 3133321 tctcgcgcgc cgcggaatgt tttcggctga taaaaggaaa tatggtatga cttctttttg 3133381 aagtctctga tatgtgatcc ccgataagcg atatcaatat ccagcctttt ttgatttacc 3133441 ttcatcacag ctggcaccgg atcatcgtcc catatatcct tttttaattc acgcaagtct 3133501 tttggatgaa caaacagctg ataaagcggt aaattggatt gattcttcat ccataatcct 3133561 ccttacaaat tttaggcttt tatttttata agatctcagc ggaacactta tacacttttt 3133621 aaaaccgcgc gtactatgag ggtagtaagg atcttcatcc ttaacatatt tttaaaagga 3133681 ggatttcaaa ttgggccact attcccattc tgacatcgaa gaagcggtga aatccgcaaa 3133741 aaaagaaggt ttaaaggatt atttatacca agagcctcat ggaaaaaaac gcagtcataa 3133801 aaagtcgcac cgcactcaca aaaaatctcg cagccataaa aaatcatact gctctcacaa 3133861 aaaatctcgc agtcacaaaa aatcattctg ttctcacaaa aaatctcgca gccacaaaaa 3133921 atcatactgc tctcacaaga aatctcgcag ccacaaaaaa tcgtaccgtt ctcacaaaaa 3133981 atctcgcagc tataaaaaat cttaccgttc ttacaaaaaa tctcgtagct ataaaaaatc 3134041 ttgccgttct tacaaaaaat ctcgcagcta caaaaagtct tactgttctc acaagaaaaa 3134101 atctcgcagc tataagaagt catgccgcac acacaaaaaa tcttatcgtt cccataagaa 3134161 atactacaaa aaaccgcacc accactgcga cgactacaaa agacacgatg attatgacag 3134221 caaaaaagaa tactggaaag acggcaattg ctgggtagtc aaaaagaaat acaaataatc 3134281 taagttttca ttgtttcaat aggctgccgg cggaggtacg gaagcctatt tttttatttg 3134341 ccctgtatta gatatatgtc atgacataac atatgcaacc cgcatcattt ggtttccttt 3134401 aaaccatttc gttataatca aggtatccta acgataaagg cggttgttgc tatgtacata 3134461 tttcaagctg atcagcttag tgccaaagac acatacaagc tattgtcagg taccgttatt 3134521 ccccgcccca ttgcatttgt gacaacactt tcttcaggag gagcggtaaa tgccgcgcct 3134581 ttcagttttt ataacgtcgt cagctcagat cctccgcttc tcagtatttc tgttaacagg 3134641 acggaaggac gccaaaaaga tacagcacga aacgcagtgg agaacggaga atttgtcgtt 3134701 catgtcagtg atgaagccat cattgaagat atcaatgaaa cagctgcaag cttaaggccg 3134761 gatgaaagcg agcttacacg cacctcgctt catcctgttg aaagcaaagc tgtttcagtt 3134821 cccggcatta aggaagcccg cgttcgcttt gagtgcaaat tagagcggca tattaccttt 3134881 gacaatgatc aaggcatcac tacagcagat ctgctcatcg gaagagttgt ctgcttccac 3134941 ctagatgaaa aggtgtatga tgcagaaaag ggatatattt taacggatga attaaagcct 3135001 gcctcacgat tggcgggaaa tcactatgcc aagctggggg aagaattcac actgattcgt 3135061 cccagctgaa gagaaggact atttaaatag aagaaactag tcaaaaagac cttatgatta 3135121 caaaatatcg cctgtaaata actgaaaaaa tatcaaaaaa aagaacaccc agagcaagct 3135181 cggggtgttc ttttatgaaa cgtttttcct ttttcttcgt ataaaggtag attaggagga 3135241 attggaatga caaacttttg gattttaatg ctgatcgcta ttaccatcag tctcgcctct 3135301 caatttttta taaagaaaaa atacggtatt gataaatccg gctggcgata taagcatgtc 3135361 agcaatacac acaaatggat cgaaatcact ttacttattt tgtttgtgtt ttcactctcc 3135421 ttttttccag ttgaatattt gcttctttta ttttttattg tgattgactc aatacgtatt 3135481 tttatggagt ggcattatag acctgaagat aaacagtata tgtaccacat tgtagaggtc 3135541 tcccttatgt ttatgctttt gatttatgtt tgtaccctat agttatttaa atccccacag 3135601 ccgctccgtc tccccgagga tcggctccgc cttggagaaa gccttcttca tcaactttga 3135661 ttgcagccgc ttgtcccatc agcggatcat agtcaccgac aacctccacg agatgcccgc 3135721 tgtctttcag tttttggatt gttttgtctg tgaatctgcc ctcgactctg agaccttcgt 3135781 attcctctcc ccacgttctg ccccataccc agcgcggttc gctgattgcc tgctgtggat 3135841 gcattccgta gtccagcatt cgggtaatga tggccgtctg ggtctgcggc tggccttcgc 3135901 cgccttgtgt gccgtacaga atttttggct ttccgccttt acagaccata gccggcatca 3135961 acgtatggaa ggtgcgcttt ctcggttcaa gcgtgttgac atgattttca tccagtgaga 3136021 aaaacgatcc gcggttttgc agtaatatgc ctgtatcacc ggcagtgact gccgagccaa 3136081 attcaaagta caggctttga atgaatgaca ctgcgttgcc atccgcatcg attacggccg 3136141 catatgccgt atcacttccc accggcctgc tttctgccgg tattgcgaga tagccgattt 3136201 cttctgccaa ttgttttgca taacgtttgt ccaaaagcct ttcaagcgga atgtctgcaa 3136261 acgccggatc agtcaggacg gcatcccgat ctagaaaact ctttttcaat gcctccacaa 3136321 gcacgtgata atactcaaat gaaccgtgtt cgatttgggt gaaatcatag ttttccaaaa 3136381 tgttcagtgt taataaaccg gtaaatccct gagaattcgg cggcgcctga tacacactgt 3136441 atcctcgata atcacttgat acaggcgctg cccactcacc ccgatgcgct ttaaaatcat 3136501 cgattgtcat gtaactgccg ttattctgta aatgtgagac aatccgctga gcgagatctc 3136561 cttcataaaa tgcgcttctt cctttttcag caatcaagtt cagactgtct gcaagctctt 3136621 tttgcacaaa ccgctctccc gggacaggtg ctttgcccct tctcgtgaag atgtcagccg 3136681 tgtaaggcgt ggaagccagc agttcaatat tcttttctgt gtgacgacac tgatcagctg 3136741 atacaggaaa cccattttgg gcataatcgc gtgcgggctc caatacatct gcaagagaca 3136801 gacgcccgta ctccttcagg accgcatccc agctatcaac cattcccggc acggtaatag 3136861 cactgtcaat tccccgcagc ggaatcgcgc tttttccctt atatacatct ctcgttacgt 3136921 tttttcctga acggccgctg ccattgtaga cttttactgc ctttgtttcc tggtgaaagg 3136981 tcagccaaaa ggaatccccg ccaagtccgg tcatatgcgg gtacacaacc gcaagacaag 3137041 cactcaccgc aacagcggcg tcaaacgcgt tgcctccctt atccagtatg cggtttccgg 3137101 cttgagaagc gagataatgc ggactgacga ccatttgctt tgtaccgatg acagatttgt 3137161 tcatcacaag tccccttttt taagaaattt tcttcagtat agggagcctg atttttcaca 3137221 tctactgatc cggcagaaaa actgacgaac tttcttcttt tcgcaaataa taagatattt 3137281 tcgcattcat ttcgaaaaca aatgaaaaat tattatttct atacgtaact tttatgataa 3137341 aatgattgct aaaaggctac gaaagcaggt ggagcaattg agtcatgaat atcaaatccc 3137401 caaccttgta cttgatgaga ctgataaaca aattctcacg attttgcatg aagaaggcag 3137461 aatttcttat acggatcttg gcaaaagagt cgatttgtca cgggtcgccg ttcaggcccg 3137521 tatcaaccaa ttaattgaag ccggtgttat tgaaaaattc accgctgtca tcaatcccgc 3137581 taaaatcggc atccatgttt ccgtgttttt caatgtcgag gtagaaccgc aatttttaga 3137641 agaggtcgct cttaagcttg aggaagagcc tgcggtcacc agcctttatc acatgacagg 3137701 cccgagcaag ctgcatatgc atgggatctt taccaacgat caagaaatgg aagaattctt 3137761 aacaaaacgg ctgtatccat tgcgaggcgt cgtcagtgtt gattgccaga tgctgatcaa 3137821 acgatacaaa agccgtatgg gaatgaagct gtaaaggaga gaaacaaatg aaaaaccatc 3137881 cttatcggga tatgacggcc gcaatggttc gcaccggcat attagggttc ggcggcggac 3137941 cttccgtgat tccgctgatc cgccatgaag cggtcaataa atataaatgg attgacgatg 3138001 atgaattcgg agaaatatta gcaatcgcta atgcgcttcc cggaccgatt gccaccaaaa 3138061 tggctgctta tctgggcttt aagctaaaag gcacattagg tgcaattgtg gcgatcctcg 3138121 cccacattct gcctacatgt cttgcgatgg tgggcttgtt tgcggctgta aatgtgttaa 3138181 gccattcagc aattgttgca ggtatgattg gtgccgtcac gccggtaatt gcggtcatgc 3138241 tcggaatcat ggcgtacgag tttggccaaa aagcgcttaa aggtttcggc tgggttaccg 3138301 gcatcctgtt ttttatcatc gcttttatcg gcctgcaaac tttacagatt aatcccggcc 3138361 tggtcattat cattttctta gcttacgggg cgtttcattt taaactgaaa gacaaaatca 3138421 caaataaaca ttcaaaagat aaaggaatgt cagcctcatg atatcgatct atttatttat 3138481 ggcgtttttt atcgcaaacc tactgggata tggcggcgga cctgcgtcta tcccgctaat 3138541 gtttgaagaa gtcgtaaaca gatacagctg gctctcaaac gatcaattct caaatatgct 3138601 cgcacttgcg aacgcattgc cgggcccgat cgccacgaaa atcgctgcgt atgtcggcta 3138661 cagcgcaggc gggtggcccg gcttcctaat tgccctgatc gcaaccgtcg taccgtcggc 3138721 gctcgcattg atcgtcctgc tgcgcatcat ccagcgcttc cgccaatcac ctgtcatcaa 3138781 aggcatgacg ctgtccgtcc agcctgtcat cgcggtcatg atgctcattc ttacctggca 3138841 aatcggcgca gacggcatca aagcgatcgg ctgggtccaa tcgatcgtga ttacgggaat 3138901 ttcgctcctt gccatgacaa aattcaaaat gcatccggca tttttgatta ttgcggcgtt 3138961 tttatatggg ggccttgtga tcccttattt atagaaaaaa gcacctggac aggtgctttt 3139021 ttattttagc ccagaaatgc cgtttgatat gacagctgtt tcttctcctg cgtcactctt 3139081 gatcatgtgc ttgacttgca gcgtggttcc tgccattctc acagattgct tcaactggga 3139141 cgaattggtt tcaacttgta tccaaacagg aggctggacc ttccaaaata aatagagtgc 3139201 aagaatcagc aagccagcaa tgaccgacag caaaaacttc atatcgcatc gcttcttttc 3139261 agtaagcggc tcgcagcgga cagcgcctga tgatcacgaa gaatatcgcc tggacgattg 3139321 ccttctccca gcacatagcc tttaaaggac attcccataa aatgaaaaat atgttcgaat 3139381 tgctgaatca gcggcagccc ttttattttt ggattgtctc cgcccactgc tattacatat 3139441 gcctgtttca ctgacatttg ctgtttaaaa tcaggaaatc tcggatctct caacgtctgt 3139501 gaccagcgat caataaacag ctttaatgtc cctgacatgc caaaccaata aattggggtg 3139561 gcgaatataa gaatatggca ctgcaatatc cgttcaatga tagaatcgta gtcatcttga 3139621 acaggacgaa agccgccttg ggcgtgacgc agatcttcaa ttggttgaat tggatatttc 3139681 tgcaaataaa tgtgctccgc atcgaatcct tgaacagcct tctccgcaag aacatccgta 3139741 tttccgccag accgagttcc gccgttaata accgcaattt tcatgatgca tctgctcctt 3139801 tgtttacgaa tgattttctt catcatataa tggattcatc aatcaataca gatgattatt 3139861 tcgattaatc caatcgctaa aaccgattta gaaaggaaga gaacaagtgg aattgaagca 3139921 gctgatcacc tttattacgg cggctgaaca tgtaaacttc accctaaccg ccaaaatgct 3139981 taattatgca caatcaagcg ttacctctca gatcaaatca cttgaagaag aaatcggaac 3140041 gcctttattt gaacggctcg gcaagcggct tatcttgaca gaagcaggaa aaacgttcaa 3140101 atcttatgca cagaagatca ttgcgttaac agaagaagcg aaaatggcca caaatcaagt 3140161 aagagaaaca accggaacct taaaaatcgg ggcgacggaa agccagtgca cataccgcct 3140221 gccccctatc ataaaagaat ttaaacaggc ttttccccaa gtaaagctca tattcaaacc 3140281 atatatctcc aatgaacaag cgaaagaaca gctcttacag ggccagcttg atatcacctt 3140341 catcttggat gtaaaccgga tggaagacgc actgcacgtt gaatctttga ttcaggatga 3140401 gatcaaaatg gtggctgcta atgaccatcc ttttcctgcg gatttaccag taacattgaa 3140461 ggatcttcaa aacgaaactc ttctgctgac agaggacggc tgctcgtacc gcacgctctt 3140521 tgagaacaat ttgcatgact ccggtatcta tcctaacaaa ttggaattcg tcagcataga 3140581 agccatcaaa caatgcgtga tggccggact tgggattgga atcttgcctg aaatgacagt 3140641 aaaagatgat attgcagcag gccggatgaa agaactcaat tggcagagcg attgccccgt 3140701 tttcactcaa ttagcatggc ataaggacaa gtggatgtct gcgccattaa aggcttttat 3140761 cgatttgaca cggaaaacat tcaaataaaa cctctccaca aggacgacaa ggtttttgag 3140821 accagggcac acacatacaa aaaaaacact tgatgactta gagccccaag tgttacacgt 3140881 gatttttctg ataaaacgtt cgcaaaacat gcgtctcaag gtcagccagg cggacaggga 3140941 tcggcagcct gctttcttga ttgatcaagc tcatcgtgat ctgatagctg ctgtctaaat 3141001 caatataatt accgcaagac aagaaaatag gcttcacgtc ccgccgcgtt cgcagcgccc 3141061 gtccatatac ctcgccgtca atgataatat cggtgtatgc gcctacttca atttcaggcg 3141121 tcacgaaatc gcagcctttg attttgagat aggttttcgc tatcccaatc gtcggcttgc 3141181 ccagaaaaaa agccgcatgg gtggcaacgc ccatatgatt gtaatgcaga tatccgttgc 3141241 catcaaacaa gaagacatcc ggctccgtct ccagcttttt cgccgcctcg atgatcaagg 3141301 gcagctcgcg aaacgcaaga aaaccggaaa catacggcac gctgattctc cccatgctgt 3141361 gcactttttc aatgacttct tttgtatcag cgtcaattac gataatacag cacactccgt 3141421 atggttctcc atcctgctcc caataggcca ggtcgacgcc tgcgcaggtg ttgatggagt 3141481 ctggatggat cgtgggggat aggttgatac gatttttaag gttaaattgc acttgtaaaa 3141541 agtcttgttc ctttttcata tcaaatttat gcacatcaaa taccttcata acgattgctc 3141601 actctcgacc taaattaatg tgagtctctc ttctcgattc tagtatttca aaatgaggac 3141661 tatctgtatc tatctcgtac ttatttaata gattgccttc ttcatcccaa ttcttttcag 3141721 aaattagtat ggaatgctca tactgttgct cacttttttt cctgccattt tcaaaccaaa 3141781 ttatgcttat accgtgcaat tgcccatatc ggtattcttt ttcacttttt ttattcccgt 3141841 tttcataaaa ttcacatgtt aaaccatggg ccagaccatt cttatattta gtaaaataga 3141901 tgatttgacc atttggatat aattcgtaag ccagccctgt aaacggctgg ccattttcgt 3141961 cttcaggatt atctaaaatc tcatcactta ccgaagagaa ccataaatcc tcaaagtcca 3142021 ctcccttttc ttttatactc ttcatatcat attcattttc catactttaa agcctccggt 3142081 atataatttg tattttgagt tatatattca caatgtggac atctaggcat tgggacacct 3142141 tctggcatct ttttatttat tttcctagca cttactacat ataccattaa atcttttaaa 3142201 tccgcatcag gtctttgaag taacgcttca tttagagcat taacttcggc atgagaaccc 3142261 gcccctgacg tctttatata accttcttta agttctgtag gcatatttac aattctatca 3142321 tgaataagtg gatgtagtac cttaggtggc ttcccatcta tattgtttat tccaaaataa 3142381 taattgcctg tttttttgtc caatacacca gctaccgcag ggcctctttg ttttttagtt 3142441 agaccagaag atttaattct actaagttcg tttagtactt ctgcccttag atttattcga 3142501 tggtgaagat cttctttaga caatacacca tgcttatttc ttaaatattg aagcctagtt 3142561 tgtttttctt cagtagtctt agcaatattg ctaataaggc tttcattact cactttattg 3142621 acatatggag catttttttg gtacaaccga tcaaagtagt gtgccaatcc tgctccacca 3142681 ataatagtaa tagcttccag cgccccttgc ttccgcttct cctcagacac tttgtttccg 3142741 aacatatccc ggcctgtgac agcttctgag aatccgtttg acgcaacaag gccgtatgcg 3142801 cccatttctg tcattttgag aatgtctaag gatttgcctg ttttgtaggc gtctaatgcg 3142861 tgttcagcag cgatagctgc ttttccggtt ttgtagatgg cttttccgcc tttgaaggcc 3142921 cggcctgccc agccgacgac tggtatgaat ccggcagcgg ccatagctcc tgctgtcaca 3142981 cgctccgcgg tggagagttt ttctccggta accggatcaa cgccttcggt tgctctttta 3143041 taatcataat agccagtgac ttctccagta aagttgcaaa ctccatccca tgttttttcg 3143101 taccacggtt tgtttgcttc ttcctcggct ttttcctgga gccgtcttgc ttctgcttgc 3143161 tgggtttttg catcgatata ggttgttcct tgattttcta cttcaatgac gcttttgtag 3143221 acttcattgc tgtggaaggc ttttttgtca tagtacatag gggatgcgct cttcccattg 3143281 ctggtggcct gcatgagaac agaatatttg gtgagcactg cgttgtccag agattctaaa 3143341 ttttgatatt cagtggtcag ggattcatca agcttatcga cagctgtgat tgtatcacgt 3143401 ctgatttttt gggcatcgcc catcttatct gcatagtcgt caagcgtgta catgtcgaga 3143461 tcaataatat cgctgatgcc tgacaaaata gaatcgattt cttctttatg agcggagaca 3143521 atctctgagg ctttcaggtc tccattgggc agctcatgat ccaaaaaaga agtttccaca 3143581 tatgaatcat tcagttcttg atctttaata tctcctgaaa tgccgtttaa aaacgcaatt 3143641 tgagcagaga caagcgtcag ccagctgtct acgatttctg cctgtccctg aaaaaaatct 3143701 ttaatattgt ccgcgccatt tcctttaaaa ttatcgccta aatcggcaac tccctgaaac 3143761 gcttttttca gcgtattcag ctgctcttca agcgtctcat attgcttttt tctgctcttc 3143821 gcttcttcga ttaaagattt tgattcaaat actttactca tcgcactgcc ctttctgttc 3143881 tattttaccg ctatcgcctc gtcctgctct ttgagtgaat ctacgttatc ctttgtatcc 3143941 tcgatatttt tctgtaccgc ttttttgtaa tctccgagca tggttttgat gttctcctca 3144001 cgctcatggt attttttcgt ataatcgagg ctgttttttc cgttggatcc tgcggcgccg 3144061 attgatacgt cagcaagcgc atctttgaca gaatctaatg ttttgatgac tgtgtcgtac 3144121 ttcagcttaa tttctgacat aaaaaaagat caccaccatt ttagtttact aattgtattt 3144181 ccgacttctt ccgcgaactc ttctcccttt ttaagaagat ctgctgcacc atttgctatg 3144241 aacaattccg atgcatattt agctttatcc cattcaagat caaaaatttt cccgttaatc 3144301 gaagccatat actcgttata tttatcattc acaatcttag atgcttccga tttcgcctct 3144361 tctcttccct tgtcgaaatc atcggctttt gttcccgtcc aatgcttgcc caattccggt 3144421 ttcacaattt ctttgatttc agtgattgcc tcttcttgca gtgtgtctat gtcctttttt 3144481 gcttttttca gcttttcgat cttgtcttcc acgtctgaaa tttttccgtt gagcgaactt 3144541 ttgatatccg ctagcatact ttcataaccc atctgaatca cctcttaata ctcaaaaagt 3144601 cgtatggagg ggctgatgaa gatagacttt tccatacttt atttccatat attatatttt 3144661 aaaatagcca gaaggcggct taaatagggt aaatggctta atttaggcat ataacgctct 3144721 tgaaatgtag gtatttgatc ttgtttttgt tcgttataca gctaataaaa gcgttttata 3144781 aaatgaaatc acctaatgtc atagttataa aggcacttga aagaggcaga tgttgttgat 3144841 ctgcctcttt cggcgctgag cttattgttc atgtttatgt tcttcatctg gtcggccatg 3144901 tctgattttg tcatttggct tctattattc cccccttctg accctttgga tcaaaagctt 3144961 gtattagctg cagtcccagt tgtacagaac gtttgaaaag tcttttttcc ttagatcttc 3145021 aggtgtgatg aaaaaattgg cgatgccgac gtctccccac attgaatcga tatcatcgtc 3145081 tgaatcaatt tgtaacagca tgatggtgtg ttctttatat gcgtattccc ggggatcatg 3145141 ctgggtaaaa gaagcgtatc cgccaatttt atggccaaat ccgttttcag ccagttcatt 3145201 ataaatgtct tcttcatcct cgccgaactg accaaagaac tccattgttt ccatgcccgt 3145261 atactgctca aattgaaaat ctgtaggcag cacccattcc gaagatttca caggctcgac 3145321 tgccgcttct gataaaatcg gaaaatcaca ttcgcctgtg ccaataaatg aaaaatcaga 3145381 aacaagctcg tcatcgtttt ctacgatatt ttcaaaatag atcactctga aattcttttg 3145441 ttcacatcga tcgtcaaaat tcaatccata gacgtcatca tgaacagaaa tgtagaactg 3145501 caggatacct gaagaagggt agccgtcaag ctggggaatg tgcgagaaat taatctgcgc 3145561 cagaagtttc atcggctgtc cattttcgtc agtcggatat gtttcatgct tggggaaata 3145621 gggatcaccg gcaattttgc tgtcatatcg tcctgttttc ccctttctca cattcagttt 3145681 cacgtattct ttcgctgatt tctccagcaa gtcgcggtac ggtctcattt tttcgggcag 3145741 atgattcatc agattctctc cttttccggc atctccaagg ttttattttc tggttttctt 3145801 ctaatgtttt tcaaacgaat gtttaaagaa gccctacttc tgcataattt tccaaacaat 3145861 agttaaatag tagcaaatgt attcagcacc ccgcaataga tgaaaaaaag actggtgcgc 3145921 aaccagcctt tctttttcat ctattgaatt gcacctgacg gaacaaccgc cttccgtccg 3145981 acagaataat actccactcc tgcagccaaa gcctcatcca atgtgtagca gtttctgccg 3146041 tcaaatatga gcggcgtttc catcaaatcc tgataagccg ctaacgggaa ttgtttaatg 3146101 tcagcccagt cggttaaaat catgacggcg tcagaccctt tgacagcttc ctcgatcgtc 3146161 tctttatatt caacagcttg cgggagaaca tgctttgcat ggctaactgc aatgggatcg 3146221 taggctctga tacgggcgtc gagcgcagcg agacggtctg caataacaat tgacggcgct 3146281 tctctcatat cgtcggtatt cggtttaaat gacaggccta aaagggcaat cgtttttccc 3146341 gtcaccccac cgagcctgtt cagcgcttta tcaaccagca tcgcctgctg attgttgttg 3146401 actttgataa cggatttcag cagttcaaaa tcatgctcga cattgccggc aatttgcacg 3146461 agggcgtttg tgtcctttgg aaaacaagag ccgccgtagc ctatgcccgc ttttaaaaac 3146521 tggctcccga tccgcttatc ctgtcccatc ccgtatgcga ctgcttcaat atcggcgccg 3146581 accttttcac atatattcga aatttcgttt ataaaactga tcttagtggc cagaaaagca 3146641 tttgaggcat atttgatcat ctcggcgctt ctgatatccg tttggtaaat cgggatttga 3146701 aacggacgga agagctcctc cagcgtattt gctgttttct catcggccgt cccgatcacg 3146761 atcctgtcac catgaaaggt atcatagatc gccgacccct cacgcaaaaa ttccggattg 3146821 gatgcgaccg aaatactgac aggctccgct agatgttcag taatcagtcc attaatcaaa 3146881 tcgtttgtcc caacgggcac tgtgcttttc gttaccacga ctgtatctcg tttgacatgc 3146941 tttgcgatgc gtttggccgc atctgtaatt tgctccagat tggcgtgccc gtcgcttttc 3147001 tgcggtgtgc cgaccgctat aaaaatgatg tctgcctgtg ccaagccttt ctcatagctc 3147061 gtttcaaagt tcagccgtcc atcagctgta ttttttctca tcagctcttc aagacctggt 3147121 tcaaatatgg gggaaatgcc ctttctcatt tcatcaatct tgtgagcgtc aatatcaatg 3147181 caggttacat gatgtccaat ctcagaaaga gaaacacctg tcacaagacc gacatagcct 3147241 gttccgatga ctgttatatt cattgtttcc ctccaacagt taaattgctg ctttgcagct 3147301 tccgtaatat cgtatgagaa catcctatca tgaatgcgaa tgatctcccg catagcctgt 3147361 cgggtacagc ctgtacagat ttctgaaatg tgattcaacc atacaataca ctattatatc 3147421 gctctcaaaa agaaagtggt gaaatgagaa tcggctgtta aaaaaaacca aacaattttc 3147481 ttcttttgac cggctgcgga ggctgtctga agatggtctg attccgcagg agaagctctg 3147541 cattttccgt cagcatataa ggaagttccg agccgaattc tttctctaga acataaagag 3147601 cctcttgagt gtgaaaattt ctcgttttca cattatgggc atctgaggct acgaaatgga 3147661 tcaaattggc ttcaaccagc cggagagaaa atgctttcag ctgcttgccg aagatccccg 3147721 caagacttcc tgaagtaatc tgagatgctg ctcctttttc cacaagatga tacagcaagg 3147781 acgggttttc gcgaatttcc ctgttgcgtt caggatgggc gataaccgga atatatcctt 3147841 tcagctgcaa atcataaaaa agctgctccg catatcgggg aacgtgatca aacggaaact 3147901 caatcaagat gtattttgta tcattcagcg aaagcagctg acgtttggca aggtcttgtt 3147961 ccacctcgcc gtagattctg atttcctgtc ccggaagcac atgtaaagga atgtcttctt 3148021 tgattaaacg tttgtttaac tgatctgctg cttctctgac tgcggctggc tcgtttttat 3148081 acacaccgtt gttatgatga ggtgtcgcaa tgatcgtccg gattccctga cgaacagctg 3148141 ctcttgccat ttctatgctg tcggccgaat cacctgcccc gtcatccatt gcgggaagaa 3148201 tgtgacagtg aatatcgatc atgtcctagc cccctttttt cgcaaaaata aataacgggc 3148261 acgatgcacg ttatttattt ttgcatgaaa ttgtccttgg ttccgtaata tccgtattca 3148321 gagtgcttcg aaagcttttt gccgttcata atcgccccaa ggagcttgct tttgcacgtt 3148381 gcaagcgcct ctttcgcttt tgcggcttgt tctttttctg ttttcccgct tgaaataacc 3148441 agaacagaac cgtctgccac gttgcctaaa atctgtgcat ctgctacggc aagaataggc 3148501 ggcgtatcaa aaatgaccat atcatatgcc gcacacgctt cgtatgcaag ctccttcatc 3148561 cacttcgagg agagaagctc ggccgggttt ggcgggatcg ggccgctcgt cagcacgtca 3148621 agatgttttt cattcgatgc ttgtacagcc tgctccatag agcttttctt taataaaaca 3148681 gatgttaagc caaccgtatt ttcaagaaaa aaagccgtat gtactgttgg ttttcgcaaa 3148741 tcagcatcaa tcaggagcac tttttttccc tgttgggcga atacgacagc caggttggcg 3148801 gccgttgttg attttccttc ccccggacaa gccgatgtaa tcatgactga tttcatttgc 3148861 cggtccactg aagcaaattc tatattcgtg cgaatcgtcc gatattgttc agagttcaag 3148921 gatttcggct ctgtcattgc aatgacattt ctctgcatcc gcgagcctct gttttttcta 3148981 agcgccaaaa tgtccactcc ccgttttttc agattggaaa ccctgtaagg tctttgctgt 3149041 tttctgctca ttcgcaatgg tggaaactgt ccctaaaaca ggtatgtcca gcaaggattc 3149101 gagctgctct tccgatttga tcgtattatc caaatgctca agcaggaagg ccagtccgat 3149161 gcttcccgcc aatccggccg caaacgcgat ggcaatgttt agtagcggct ttggcgatac 3149221 aggggacggg tgttctgaaa cctcggcttt tgacagaatg ctgacattgt caacattcat 3149281 aatggatgtg attttgtctt gaaaaacaga tgctatagta ttggcaatat gagccgctgt 3149341 ttccgcgttt tcatccctga ctgatatgtt gaccacttgg gagtcctgtt cgctggatac 3149401 ggtaattttg tcattcagtt cttgggatgt catcgacagg cccatttctt taatgacttc 3149461 atctaagatg gcagggctct taatgatgac attgtacgta ttgattaact gaagattggt 3149521 ttggacatcg ttaaattgga cttcttttcg ttcatttttc gattggttga ccagaatctg 3149581 agttgaattt tcatagatgg gtgtaagtgc gaagaaacta atgagtccgc cggcagcagt 3149641 ggcagccgcg gttacaatca taatcaaaag tatgcgtttt gttaacgttg ataatatctc 3149701 ttttaagctt gtagattctc ccatgatacc tccaaatctc ttataacatc cttttccatc 3149761 tacgattata caacgttgaa accgcatttc tccagctttt cacgtgacat aattcgacat 3149821 ttttttacaa tgcgttatgt tagtactttt tatgtaagcg ctatatttac tgtgttgaca 3149881 gtgctgtctc attttctctt attcgggcag tcacgttctc tcgcataaaa aaatcccgct 3149941 aaaggcgtgc gggattttta tgttgcatat ccatttttaa tatgagaaat caaattttca 3150001 agcatttcct tcgtcgtcat ctcagatgac tgctcaccaa tttcatgtgc atgcatcaaa 3150061 attttcagaa attcttcttg attcaatttc ttttcactca tctttttttt cctttcagct 3150121 tccattaagt tgaaaacacg attattatat gatgctggtt atcaatttgc aatctctaat 3150181 acatcattcg acacatccta ttttttatgt ccttttttag gaaaaacttt ttaaggccga 3150241 tgtgttgcga tataatagag aaattggatc tttttattac gtgactcggt taggagcgat 3150301 aatcatgctt cagaatatga tttccaaaga cgatgtgctg gcatctgctg aacagttaaa 3150361 agaacttctt ccttacaatg aggaaaatgt tcagctgatc aaaaaagccc ttattttata 3150421 tcggcaggat tcagtctatc gtttacaagc agtgagtccg acggaagtta cggcttacgt 3150481 gcaggatgtt gtgcctgtgc gggtcacatt gaacttgttt gtcatagtca aaagcggctg 3150541 ttcatgtccg tccggaagaa tctgccgcca tatgctggct gtgtttttat atgtatatgc 3150601 aatgttcgag cgagtgggta cttttacaga gtattggctg gagagggaaa agcttgagga 3150661 aagcaaagag ctcgtccgcc gccagtttca ggaaaaggtg ctgcctaatg aagaatcact 3150721 ttcaagctgg cttgcttttt ttgattcaga gttttctctc tggcaggcac gtacgccaga 3150781 aggcagccaa aacatgcagg gcctctatta cggctacctg tccgcattaa aaaaacatgc 3150841 gccgaacaag ccggagctga aaagcctgta tcagattcat tccgcgattg cggtttggct 3150901 tcgcatgttc acattgattg aagcgggcaa gctaaacccc gaacaagatt tttattccct 3150961 caatccgtac gttgaacagc tgatggatac aatctacagc tctattgata aattaaaaac 3151021 gtacgcgctg tcttttgcgc ttgatccgtt tttggataaa acaccggatg ttatccggca 3151081 tttgctgttg aaagaagaaa ttttccaata tgaacgcatc cgcgtcttcg gtgaaatttg 3151141 gagtgcgctg ctgtcgcggc caaaatgggt ggcacgcgaa caggagatat tgaaaaaaga 3151201 agcaggacgg cgtttttctc ccgaattgca attcgggcgc ctgcatttgg aattcctgca 3151261 aaaaaatgat gacgttattt ttgaggaagc ggatcaattc ccgccggaag cgctccctta 3151321 tacattccaa tggctgagtg aaatgactgc caagaaggac tggaaacggc ttaaaacatg 3151381 gtaccagcaa attgaaccaa ttgcgatggg ttatacgaag ctggataagc cgtttaaaga 3151441 gattcgcgat gtgatcggcg agctgttcct tctgttgaat gcctatgtgc agcaaaccaa 3151501 tgatcaagcg ctgtttgagc gctttgccgc gggctgtctg ccgtatacgt tcacagaata 3151561 cagccatcat ttatatgaaa aaaaacgcta tgccgagtgg attgaaattc atagccttgt 3151621 cggcttttcc atcaatgaaa tggataaaat gatgctcaag gaaattgcag cgagcgaccc 3151681 tgaggcgctt ataccggctt accatagaga agtggctttt ttcattgatc agaagaaccg 3151741 tagctcgtac aaggaagccg cccggtattt gaaaaaattg cgcaccctgt acaaaaaagc 3151801 gaaaaagcag aaggtgtggg agcggtatat tcagctgctg agctcgcatt acaagcgcct 3151861 gcgtgcgctt caagaagaac tgcagaaagg aaagttgatt gatggcgagt cttaaagaaa 3151921 ttctcatcca cgtcgaacaa atggaagatg ggtcatttac gctctcagcc tttgatgaga 3151981 atgagcagcc tcttccctac agccatatga aaaagcattt gttccaatgg catgaatcct 3152041 cattttacgg aacctttcta gaggatgtca gcttcatcgg gacgactgct gtccttctat 3152101 ctccatggat gactgtagag cttctcggca aaaactcgtt caactcattc agctccgtgc 3152161 agcttacaga agaaacggag ccgctgatcg aggcggcatc gaccatctat gaatttatcg 3152221 cggacggcga ttttatgcct gactatgacg catggacaaa cggtgttttt cgctggaagg 3152281 accgcgataa tatactggaa ggctttactg cggaatggtt ttccgctgcc gtacaggatt 3152341 acatccagta cgacgatgac ctgcgggaga aatgggaaca tatcaaggaa aaatcgcctg 3152401 cggttacgac attccgtggc cattttcttg atgaagagga ttttctggaa ggcattggct 3152461 ggattgacga tcaatctcca tttactgtcg gcttgcgctt aaatgaaccg gactttgacg 3152521 gagacgaatg gaagatcgag atgtttttac gcgataaaaa gagcggtgct gtagaattct 3152581 ttgacggact gaagagcctc aaaaaatcgt ggcaggcgta cagcgataaa atcgcgcgtg 3152641 agcaggaccg ctttcacaga acggttccgt ggctgtcgtt tgattccggg acaacgctga 3152701 tctcggagga agaagcctgg atcttcctgt cagaagcaag tgagacgctt gtcgatatgg 3152761 gggtagaaat cctcctgccg tcctggtggc agattgtcag agacagcaac atgatgctga 3152821 aagcaaaggt gtcttcctcc ccgcgcggcg agtcatttgt cggcatgaat gcactgcttg 3152881 atttcaactg gcggtttgcg acaaatggaa ttgaactgac tgaggctgaa tttaatgagc 3152941 ttgtcgccag caacaggcgc cttgttaata tccgcgggca atgggttaaa atcgatccgc 3153001 agtttatcaa acagatgaaa cgcctgatgg aaaaagcaga atcagaggga ctccacatgt 3153061 ctgatattct ggcgcgggag ctaatggatc agcaggatgg cggacttgag gattcggacc 3153121 tgattgatac atctgctttt gccggcattc agtttgatct gtctaaacag ctcaggtcac 3153181 tgattcgaaa gctcactgcc gcggaaaacc tgccggagca caaagtcagt ccttctttca 3153241 aaggaacgct ccgcccttat cagaaatacg gcatgaactg gctgctgttt ctgcgggaaa 3153301 gcggttttgg cgcctgtctg gctgacgata tggggcttgg gaaaacgatt caaatgatcg 3153361 cctatttcct tcacgtgaag gaaagcggcc gacaaaaaac gcctcatttg attattgcgc 3153421 cgacatccgt acttggcaac tggcagcggg agcttcaaac ctttgcccct gatctgtctg 3153481 tcgcgctcca ttatgggccg cgccggccaa agggtgatga tttcgccgcg cattatgaaa 3153541 acgcagacgt ggtgctcact tcatacggtc tgtcacatgc cgatactgaa gagctttctt 3153601 ctgtgacatg gaacacgatc tgccttgatg aagcgcaaaa tattaaaaac gcgcatacga 3153661 agcaatcacg cgcaatcagg aagctgaagg ggcttcacca tatcgcgctg agcggcacgc 3153721 cgatggaaaa ccgactgact gagctgtggt ctatttttga cttcatgaat aaaggctacc 3153781 tcggcagttt gaccggcttc cataaacgct atgtgctgcc gatcgaaaaa gaccgggacg 3153841 aaaagagaat cggacagctt cagcaattaa tccggccatt ccttctccgc cggacgaaac 3153901 gggatgaaga ggtcgcgctt aatcttcctg agaagctgga agaaaaagaa tttatccctc 3153961 tgtcagccga gcaggcatcc ctttatgagc agctcgtcaa agacactttt gaccatatga 3154021 catccctgac cggcatgcag cgaaaagcgc tgatcctcag catgcttgga cggctcaagc 3154081 aaatatgcga tcatcccgcg ctttatttaa aggaagagca aaccgagctg ctggccggca 3154141 gatcagtcaa gctcgaaaaa ttgctggaac tgatgacagc gatccgcgcc caaaacgaaa 3154201 gctgcctgat tttcacgcaa tacattcaga tggggaacat gatgaagcgg ctgcttgaaa 3154261 aaacgttcgg ggaacctgtg caatttttaa atgggagtct ctccaagcaa gagcgggata 3154321 cactcgttga gaaatttcaa aggaaagaat atccgacact gattctttca ctcaaagctg 3154381 gaggcaccgg acttaatttg accgccgcca atcacgtcat ccattatgac agatggtgga 3154441 acccggcggt tgaaaatcaa gcgactgacc gtgcataccg cataggccag gagcgctttg 3154501 tccacgttca taaaatgatt acgacaggaa caatcgaaga aaaaattgat gtcatgcttg 3154561 aatccaagca aaccctgaac gatcaaatta tccaaagtga aaactggatt accgagcttt 3154621 ccacacagga gctcgaagaa ttgtttacat taagcgctac agcgcaataa tcatgactaa 3154681 aaaagctggc tctaaaagag ccagcttttt tccgttcata gccgtcacgc cgaatttcca 3154741 aaaaatccgt tacgccggtt atcaacaggg tgcgcttttg tggcagcaca tatacttaca 3154801 acaaatgttt catcatatgt gcgacaccgt gttcgtcatt ggttaaggtg acagcatcgg 3154861 ctatcgattt gatgtcttcc cgggcattgc ccatcgctac accttttccc gcagcctcca 3154921 gcatcgattt gtcatttaaa ctgtcaccta cagcagcagt ttcctcgagc ggaatattca 3154981 gctgttttgc aagcctcttc agcgcctgcc ccttggaagc tttgcgggaa gaaagctcaa 3155041 agttgtgctc agccgaactg acaagcgtca aatcttcggc atgctcatat cttttccagc 3155101 ctgcctcaag cttttctttg aagaaagaaa agccgagaat attgtaaaaa tcgattggct 3155161 catcggcttc aaacagctct tgaaaggagt taatgtaagc aaagcccgat tggctgtatt 3155221 gcacctcggc cgcctgctta aggacagaaa gatccgcttc cggatttgcg cttctgaatc 3155281 tgtcgagctc aacatcaaga agttctctgc cgttttgcgg cgtataaatc gctgaacctg 3155341 tgaatacctc ataataatag ttttccgact caagccatga gagaatgtca tacgcccgtt 3155401 tcttatcaat cgtttcgtga tgataaagcc tgccctcggg atcgtgaatg acggcgccgt 3155461 ttgcactgat gacccatgtt ttgatcccca gcggttcaaa gattgacatg acgtcaaaat 3155521 gagcgcgccc agttgacacc accacttcaa tgccgtcccg ctgcgcctgc cgcagtgcgt 3155581 tttcattttc caagcttacc tgatgcttgc tgttgagtaa ggttccatct aagtcaatcg 3155641 caattaattt cacgtttgtc agtcctttcc ttcatcctgc tctgtcacga gaagctcaac 3155701 gccgtttcgg tcaagcaagt cacaaaatgc ctgattcggc agcctgtctg taatcaagag 3155761 gtcgatttca ttcagctccg catactgata aaaactggtg ctgcccagct tagaatggtc 3155821 tgcaagcgca attacctgct ttgcctgctg tatcattttc cgcttcacca tgccatcctc 3155881 ttcatgcgca attgtaatgc catgttcgga aatgccgacc acaccaatca gcgctttatc 3155941 aacatggtag cttgagagct tttcaatcac agaggacccg tacagaaagc ggtgctcctt 3156001 ttccagcttg cctcccagca gataaatttc aattccctct ttatcggaca gcacatccgc 3156061 aagattaatc gaattggtga ttacggtaca atcaaccgca ttcaaatgct ttgcacatgc 3156121 ctgaacagtt gtagaggcgt ctaaaatcac ccggtctcca tcatgaataa gcgatgctgc 3156181 aagcctgccg atcttatttt tttcctcaga cactgttttc aggcggccgg aatagctttg 3156241 aattttctga tgcacagtcg gtaaaatggc gccgcctctt gtgcggatga tggcattctg 3156301 ttcctcaagt ttcacaagat ctcgtcgcgc tgtatccctt gacacttgca ggagcgtaca 3156361 gatctgctcc gttgtaattc ggttatgctg ttttaaaaaa tccaaaatcg ctactaatct 3156421 ttcttcttgg tacacgccct cattcctttt ctcagcaatc atttataagt aattataagt 3156481 ttttatttga ttttattcaa cattaataag tgattttaag taaaaatgcg tcgagagaac 3156541 caatttttcc taagtaggca aaaagaaaga accagtctgg tcgactggtc aattttgagg 3156601 ggatgatgcg aagatccgga taatagtgaa tggatagata acgggaggag caggggtgtc 3156661 aatcagcagc tttttcccgg ggtttagggt ccataaaacg aacagtgtca gccaacactt 3156721 ctgttacata cacgttaacg ccttcctcgt tttcatagct tcttgtctga atccgtccgc 3156781 ttacgccgac gagagaacct ttttggcaat acaacgccgt gttttcagct gtttttctcc 3156841 aaagtgtgca attgacgtaa tcagcttcga tttcacctga agcattcttg aagctgcggt 3156901 tcaccgcgag cgtaacatgt gcaactgccg caccggcgga agtgtagcga agatcaggat 3156961 cttttgtaag acgtccgaca agcatgacct gattgaacat gcgattcctc ctctccttgc 3157021 ggttgtatgt attgtaaatg atgcaacaag aaaagaaaaa cgcttaaaaa tggctttcag 3157081 cctctgtttt tatctttcgt tttcattttt ccttcagcta aaaacatctt ttgctttttt 3157141 cctttgaaga aatatgtact ttttaaaaaa cggaaaaaga tttgctttgt cagccagttt 3157201 tgcgtattca tgcgcacata ggaagagcca tcccacgcaa accactgaaa gctcaatttt 3157261 ttttccggca ttgacagctt gattttatac tgctccatgc catcttgtgt ttcgtataaa 3157321 aaacttattc ttcctttttt gttcagatga acctcaaaca cttctttacg gcttaacata 3157381 tatgttactt ccttttgaat caaatgactt tcagaaggaa cgccgtcaat ataaatttct 3157441 tttaaacgaa attgattcat accacatctc tccgtaatcc atagtcagtt acagtataat 3157501 gaaaaaatag aaattattaa atgtttcgct catacaaaat tctttagccc caacattgca 3157561 ggattttttc ctcgaaaacg tttatgttat aatggaaggc aagaaaactt tggaagtaat 3157621 cggggtgaga agaaatgaaa acctttaaac tggttgacct gaatgtggaa cgagtggaca 3157681 aggaagaaca atcaattgaa cagtttcccc ttattgacgg actgattata aataaagaag 3157741 acggtgaaaa tcactggctg attgaggcgc ttgtacagaa agaacatctg tctttttttg 3157801 aacagcttca aaacagccaa tctgaagcca aagtatttgt aacgatcacg aaaaaaagca 3157861 atcgccccgc ccagctgaca gcagcagtga aaaatatcgt caagctggaa gaaagcattc 3157921 aggttttact ctacggacaa atggtcacaa gaaaacagca gggcactgaa accattctcg 3157981 agtcccttgt aaaagagggc tatacaggaa caaaactcat tgaggcattt aagcaaaaat 3158041 tataaatatg agggggcatg ttccccaaaa cagactcaga accgaagagc atcacaatag 3158101 acatttagaa tagatatgtt ctgcatgaaa aaagctgccg ttttgaacgg cagcttttct 3158161 cttcgtgctt tcactcttgc atatttaatt tgtatggcca aaagaatcaa ccaattcccc 3158221 tttcacaacg aggcgccctt cggttttgac cgccttgtca catgtgatta acgtaatctc 3158281 ctttttgttt gtctcctcaa ctacatctgc atccatttcc gatatgatgt ctttcgatgt 3158341 tacagaatag atataatcct ttttaaaatc cgtgatgaca atttgggcac ctgtttttat 3158401 gttttccaga ggtccgaaca gaagattctt ttgcttcaaa tgatggcccg ccaacggata 3158461 atttccctca cccatttttt gatcccggcg cattgttgcc gcccctatca aaagattttc 3158521 attggttgtg ccttttacga tcggaagctc cagatcgaca cttttaattg ttatccgccg 3158581 ccttgattgt gaagtaaaaa taagtatatt tcacgtgctt tcgacgttct ccacttgact 3158641 ggaatgcttt aatggcgatc ccggcatctg tagcttcagg ctttccttca gaggaatcag 3158701 aaatctcaaa ctctattttc tcagtgttca gcacataacc ggctggcgct ttcgtttcaa 3158761 caaaagcgta ttgtcccggt gcaaggcctg aagctgtgac ttgatgatgc cggatatgac 3158821 tggtttcgaa gtctgtatga aaattcgcga acgattcagc atggttgatc ttccggttct 3158881 gatcattaca gctgccatta tcggccatga caaatacaag gcttttcatg ccggagcgaa 3158941 tgacattttg caaaaaccct atcattactc tgaatttatg gcgcgtattc aaaacctgat 3159001 aatgatgaaa catacagcaa atcaagccac aagaatggaa atggcgtttc tccagtcgca 3159061 aatcaagcct cattttcttt ataatgtatt aaacacgatt atttctctca ctcatttgga 3159121 tattgaaaag gcccgggagg taacagagga atttaccaac tatttaagaa tgagttttga 3159181 ctttcaaaat acatcagcca tcagttcctt cagacatgag ctttcgatta tcaattccta 3159241 tctttctata gaaaagacgc gattcagtaa tcggcttgag gttcttttcg atatagatga 3159301 agacattgac tttatccttc cgcctttaat gattcagccc ttggtggaaa atgccgttct 3159361 tcacggtgtc agcaagaaaa gaggcggagg atggatcaaa ctgacagcta aaaaacaaag 3159421 caaaaatgag tatcacatca aagtagagga taacggtccc gggataactc cggaaaaaca 3159481 aatagatctc ttatcaacgg attttgatcg cagcgtcgga ttgaaaaata tcaatcagcg 3159541 gctgaaacat ttttgcggaa gcgagttgat gatcagcagc actccggatg caggcacctc 3159601 tgtctcaatg ctcattcatc tcgctgaaac aacaggaagc cctaaagaac tgaaggacac 3159661 agaacgaacc taaacgaaaa ttgagataaa aaaagacgcc gtttctaacg gcatcttttt 3159721 tattccggcg actttgcttg ctgcttcagc aggtctctga tttctttcag cagctcctcc 3159781 tgcgcatcca ccgcttcctc cgcagcctct tcttctgctt cttttttgcg ccttaaccca 3159841 ttcaaagtcc gaatgacgat aaaaatggag aacgatataa ttaagaagtt cacaatcgtc 3159901 tgtataaagc tgccatattt cactacagca tcgccaaacg taaacgacag gcctgaaaag 3159961 tcaagccctc ccagcagcaa accgaccaaa ggcataatga tatcatttac tagagatgtg 3160021 acgatctttc cgaaagcgcc gcctatcaca acaccaatcg caaggtctac gatattcccc 3160081 cgcatggcaa aggctttaaa ttcattccac atacaatcac ctgcttttct atatttgtaa 3160141 agaaaaaaag acaaatgtgc cgctggccat ctgccttttt tcaattattc tccgagggca 3160201 aaagtcagtt ctacttcgca aacgacttcg ccatcaactg tggcaacgcc ttttccgcgc 3160261 ccgattgtgc cgcgggcacg aatgatttca acctcaaggt gaagctggtc accaggcttg 3160321 acttgttttt taaagcggca gttatcaatg cctgcaaaaa aagccagtct gccgcggttt 3160381 tcttctttaa tcaacatcgc aacagctccg acttgagcga gtgcttctac gattaatacg 3160441 ccgggcataa ccgggtactg aggaaaatgt ccgttaaaga actcttcatt agcggttaca 3160501 tttttatagc cttttgcccg tttgccctct tcaacttccg taatccgatc cacaagcaaa 3160561 aacggataac ggtgaggaat aatttcttta atttgctgag tatcaagcat tgtcttgaca 3160621 tctccttcat ctgcattagt atgtatagca atcatcaaag atccaatctg tacatttgaa 3160681 aagtatatta tgaattaatc tctttttcaa ccgcgctaaa atgtaaccaa ctgtcaatga 3160741 gagccgtcaa aagttatgat atgataatta tagattttac caatagcaaa gaggtaggaa 3160801 aatgatttcg aagtttattg aaaaaagaat gctaaacatg ttagacgagt ggtattccgc 3160861 aatgagcaaa cgcaaaatga atcacgtttg cacactgaaa gagaaaattg atcagcacct 3160921 tccaaagatc aaaaagaaca caaaactttg gatgcgttat caattgtttc aggcccgcca 3160981 tcagctgctt tttgaaaacc agaacggact cgattcattg ttcgatggcc tatatggcct 3161041 ggaagacaaa atggatgatg aattgaaata ttatctgtat tttttctctg ggttatatga 3161101 gatggtaaaa acagctccga aacatgcagt acatcatttt aaaaaagctg aacagtacct 3161161 ggccgccatt cacaatacgt ttgaagccgc tgatttatat tatcaaaccg ccggcgccta 3161221 ttacttgatg aaatcaccgc cgctttccgt ccaatacgtc aaaaaagcat tacacatcta 3161281 tttgcaccaa ttcggctata tcaaaaaggt aatcacctgt aaacttttgc tcgccgtgaa 3161341 ttatattgat caagaacgct atgaaaaagc tgaacagctt ttcaaagaaa tcattaagaa 3161401 aacccagcaa ctacatgacg aaaacctgct atgccacgct tattataacc ttggcttttt 3161461 aaaagcgacc gagaaaaaag accaggaagc gcttctttac tttagaaaag tattaaagaa 3161521 tcaagaattt gaaatgaatt caccagtctc atatcttcat tgtgtgtacg agtctgtcag 3161581 agcgcttttt aaaacaggga acatcacaga agctaaagcc gtccttcaaa aaggaaaaga 3161641 attatctgaa aaggtagaca ttcaaaccat ttatttaaaa ttaaaaacgc ttgaagccct 3161701 ctacacatca gccgaagacc cttatgagca gctgctcgaa tatgtgcttg aattagaaaa 3161761 aatcgaggcg tgggtggatt tagaagtgct gttagaagat attacggaat actacaaaaa 3161821 aaaggacgat ttcgaaaaag ccgctttttt tatcatgcgc ggctgattga aaaacgccca 3161881 ttttcttatt atctgactga attgattaaa ccgagcattt gatctcccat tgtgatcgtt 3161941 ctgctgttca gctgatatga acgctgggac gtgatcaaat ctgtcatttg ttctgaaata 3162001 tcgacattgg acatctcaag tgagccctgc tgcatgccga tgttttgtct attagcgccg 3162061 ttcagctctt caaaagctgc cgcattatca atagagaaaa ggttattccc ttcggatttc 3162121 agctcttgag ggttattcac ttggacaacg ccaagattaa accgctgaac cgcgtttccg 3162181 tcagatgcgg ttaaggtgcc gttcttatta atggtgatat tcttcattga gctgtcgatg 3162241 ttcactgtat tgccgttctc atcaagtacg ggatacccat ttccagtgac gagctgcagc 3162301 tggttggcat tcgcagcgga cggcgttaca tacagcgccc cgtccctcgt atactggcgg 3162361 tttccattta catttacctg aagatactgg tatggagacg taaatgcgat atccagatcg 3162421 cgatcggtct tctgaatgct tccttgatca gagactaggc gtgaactcat catcgctccg 3162481 acgccaaggc gcaagccggg cggcgttttt cgggcttttg ccacttcctc gtttttttca 3162541 tcaacctgat cgaattgctg tctgacaagc tcagaaaaat tcgtatcttt tgccttatag 3162601 ccggttgtgt tgctgtttga aaggttgctg ctgattgtgt caatctgctg ctgcagctgg 3162661 tttaaggttg ttgatgccgt tagcattgac ctgagcatag ttgatgtccc ccgttttttt 3162721 cttccgtttt cttaaatttt tccaatttca tttgctgctt tatccatact tttatcgtaa 3162781 gcctgaataa ccttctgatt cgcctcaaac gatctgtacg cttcagtcat ttctgtatag 3162841 gcgcttgtca catccacgtt tgaaagctct gagacgcctt gttttaatga ataggctacc 3162901 tgattatttc cggctgcgct tggcagatca ttaccgtccg ccgtgctgta caaatcattt 3162961 ccgtcccgtt tgagattgcg gacatcttcc gccattctga catcaatctg gccggctgtg 3163021 cgtccgttcg ttgtcacagt accgttttca gacacagtga aattctcatt atcaacagtg 3163081 attggctggc gatccgtcga taaaataggg cgtccgttga tcgtcagctg attgttctca 3163141 tttagtgaaa atgtgctgct ttttgaataa cggattccat ccgctgtttg aaccggataa 3163201 aaaagagcag ctttttcatt ggtttccgca ctcatcggaa cttgattttc gatcaatgca 3163261 atgtctgtag gctggtctgt ggacttcagg cttccctgtg taaagagagg cttgagctcc 3163321 tgcatatata ctccggtatt cacggaaccg atttccgtcc ttgatgtccc ggccggagat 3163381 tttgattcta ttctgctgag cagcatctca gggaacgcgc gcatagagcc ttgatcagct 3163441 ttatatcctg atgtatttgc gttagcaata ttatttgaaa gcatttccgt tcttcgctgc 3163501 tgggcaatca ttgcggatgt tgctgtatat aatcctttta acaaatttcc cacctctaaa 3163561 aatggcattt tttccagttg tcatatagga acgttcgttc tataataaaa actcagtatt 3163621 ttatcctatt atcgtcattt aacatctttt cgtgaaggct ttttcataaa aaaacctcat 3163681 tctttttcag aatgaggttt gtgaaatcag cttagtttgc gtttaggaag cttgtccata 3163741 ttatcaagca tgacacctgt gccgatggct acgcaatcca taggattttc agcaacgagg 3163801 accggtacct tcagctcttc agcaagcagc tggtcaaggc cgtttaagag cgcgcctccg 3163861 ccggtaataa taacgccgcg gtcaataata tcagcagaaa gttcaggcgg tgttctttcg 3163921 agcacttgtt ttgcagcctg aacaataaca gcgacagatt cacgaagggc ttcttcaact 3163981 tctttactgt ttactgtaat tgttcttgga agaccggaaa ccatgtcccg tccgcgaatg 3164041 gaaatttcct cgtgacgtgc gtctgggaaa acagttgcga ctttaatctt aatatcctcc 3164101 gcagtacgtt cgccgatcag cagcttgtac tcgcgtttga tataatttaa gatttccatg 3164161 tcaaacttgt ccccagccat tttaatagaa gaggaggtga caatatcgcc cattgaaata 3164221 accgcgatat ccgtcgtccc gcctccgatg tctacaacca tgttaccgct tggctggaat 3164281 atttccatac ccgcgccgat agcggcaact ttaggttctt cttcaaggta cacatgtttc 3164341 ccgccgcttt tttctgcagc ttctttaatt gctttttgct caacggatgt aatattcgtc 3164401 gggcagcaaa tgagcatgcg cggctttgag aacaggcctt ttacattcag cttgttaata 3164461 aaatgtttca gcattgcttc tgttacttca aagtcagcaa taactccgtc tttcagcggg 3164521 cgaatcgcaa caatattccc aggtgtacgt ccaaccattc gtcttgcctc ttcgccaacc 3164581 gccagcactt tgccgctgtt tttatcaagt gcaacaacgg aaggttcatt cagaacaatt 3164641 cctttacctt taacatggat cagtacattt gcagtaccga ggtcaatacc aatatccctt 3164701 gcaaacatct atttatatcc tccttgaaaa tctgtttcac agtaaatatc cacattgtgc 3164761 cctaattata tatattatca taaaatatag aaaaaaagtt ggaagcacaa taagttcttt 3164821 acaaattttt gcggatgttt tatgaacgat ttcaagaagg caatgccagg tgattacgat 3164881 tgctgaacag gctctccttc gagaatttca tcttttttat atttgagctt tgtcgcttct 3164941 cctcctctta aatgcctgat ggatttatga taatcgagta tttctttcac ttcgtttgcc 3165001 aagtcggggt taatttcagg cagacgctct gttaaatcct tgtgtactgt acttttggaa 3165061 acaccaaatt ccttcgcaat gacacgaacg gttttctttg tctccacgat gtacttccct 3165121 atcttgattg ttcgctcttt gatgtaatcg tgcacaccac tcgacctccc taaaatggat 3165181 gtgagaagtg tgaaatgaga tccgtattct gtaaagagtc gttcattatg ccgcttcttc 3165241 gttgtatggt tttaaaagta agtttgtgaa atatgcccac gatccctcac ctcaaacact 3165301 ctctttgtta ggtttgtaac agtgtattag cattcttttg ggaatatgct aaaaactcaa 3165361 taaggacaag gggtgaaacg aactttttca gattcagcaa actatttcgc gtcactaaat 3165421 tttcatcttt acaactattg atcgctcctg taaaatgaaa taagcaatta gttacttagg 3165481 taagtttttt agaaggagac cgacatgtcc tacgtcaaca gacacctcat tcatcaaatc 3165541 aaccaaagcg cccgcctgat tgccaagaaa gccaatgaac agctagagcc attcggcctt 3165601 tattcatctc aatggtcagt tttatattgt ttgcgtacga tcggaccaat gactcaaaaa 3165661 gagatttggt cctatttaaa tgtggaagcg ccgactgtga ctcggacgat caaacgcctg 3165721 gaggagaacg gctgggttca gagacggcaa ggtgaagaca aacgggaaaa acttgttgtc 3165781 ctcacaaaag aagccgagaa aaaatacgaa gaaatcaatg tgaaaatgtt gaaattcgag 3165841 gaagagctgc ttgcagattt ccgggatgaa gataaagaag ctttttctca tttattccgc 3165901 atgtttttac aacaatgaaa ataaggaagt gacatacatt tgaaaaaagc ggatgcgata 3165961 tggaccaagg attttattat ggtcctgctt gtcaatttat ttgtgtttgt gttcttttat 3166021 acatttttaa ctgtattgcc gatctataca ctgcaagagc ttggcggcac agaatcacaa 3166081 ggcgggcttt taatcagcct gttccttctg tctgcgatca ttacacggcc tttctccgga 3166141 gccatcgttg agcgtttcgg gaagaaaaga atggcgattg tatcaatggc gctcttcgcc 3166201 ctatcatctt ttctgtatat gccgattcat aacttttccc tgctgctcgg attgcggttc 3166261 ttccaaggga tttggttcag cattttaacg actgttacag gtgcaattgc cgctgatatt 3166321 attccagcca aacggcgcgg tgaagggctt ggatactttg ccatgtctat gaacctcgct 3166381 atggcgatcg ggcctttcct tggcctgaat ttgatgagag tggtaagctt tcctgtattc 3166441 tttacagcct ttgcgctgtt tatggttgcg ggcttacttg tttcgttctt gataaaagtg 3166501 ccgcaaagta aggacagcgg cacgactgta ttccgttttg cgttctcgga tatgtttgaa 3166561 aagggcgcac tcaaaattgc gacggtcggt ttgtttattt ctttctgtta ttcaacagtc 3166621 acatcatatc tgtctgtatt cgccaaatca gttgaccttt cggatatcag cggatatttc 3166681 tttgtttgtt ttgcggtgac aatgatgatt gcacgcccgt tcacagggaa attgttcgac 3166741 aaagtcggac cgggcattgt catttatcca tcaatcctga ttttctctgt cggactctgc 3166801 atgctgtcct tcacacatag cggcttaatg cttctgcttt caggggcggt tatcggtctt 3166861 ggctacggat caatcgttcc ttgcatgcaa acattggcga ttcagaaatc tccggctcac 3166921 cgctccggtt ttgcgacggc aacgttcttt accttctttg acagcggaat tgctgtagga 3166981 tcgtatgtat tcggattgtt tgtagcatct gccggcttct ctgccattta tttaacagcg 3167041 gggctgttcg ttttaattgc tctgcttctc tacacgtgga gccagaaaaa acctgcagag 3167101 gctgaaggaa aagtgtctat tgcagaataa cttgtcagac tgccgggaaa tcccggcagt 3167161 cttttttcca ttaaaacacg gcgccctctc ggttgaacga gagaacgccg cttatagcaa 3167221 ttattcaatg acaggccgcg caggtgaatc aggatctaac gaaaaatcat aggacgcttc 3167281 atcacgaaac atcggatcgg catatatgga ttgttgatcg ttttttgttg cttttcgata 3167341 cgaagaaaat gaatcatatt ctttcttttt ccacatccat atgccgtctt gatccgcttc 3167401 cttgtggtac acgttatgat tgaccgtatt accttcgttt tctgtaaagt cgtttccgat 3167461 aaataatctg gaatcaccgg ccgtcaatat attcttttca attgtgttgt ttttcgtatc 3167521 gtactgcagc agcagctgtc cgccgtacag tccctttgtg tcattccggt acataatatt 3167581 gcgggcaatc agagaattgc tggtgccgcc ccgctttttg tcatatcctc cgattgaaat 3167641 accggtgtac gcattgttgt acactttgtt gtctgtgatc tgaatggcat ttgcatactt 3167701 tcctttgtgt tcagacgttg cttcaatccc aatatcgtta tcgtaaactg tgttgttctt 3167761 aatttcgata tcgtgtcctc catcgacata aatcccgccc gctgagtatt catctccata 3167821 agcaggattg ccgtaagtcg agttttgata aactgtattg ttttctacga ctccgtttcg 3167881 cacgtaatcg tttttatccg cggttccctc ataaccaatt agatcaatcc cgatgttatt 3167941 attgttgcgg accacattgc ctgcaactgt gaagccgtcg atattaccgt tcagcacaac 3168001 tgcttcactc gctccaagcg tcagtttctc aactgtattg tcctcgattc ggatgtcttt 3168061 catgctgcca gtcccataaa ctgcgattcc gtgagcattt ccttcatccg ctgttgtctt 3168121 aatcccccgg atgtgattat ccttaatggc gatatgactg ctggaccctg atacataaat 3168181 ccctatagca gttgcttcct cagatgaaac agaaagatct tgaattgtta aaccgctgat 3168241 ggcaatgtca tgtttatcgt gaatacgaat aagcggtgtt tcatattcag cgttcgcaac 3168301 ggattcaccg ctaatcacga cgttttcatt ttcatagttt cggaatgtga taggctttcc 3168361 gtccgtaccg ctgtgcttta catcaagggt ctcatgatac gtgccctccc gaatcatgac 3168421 agttgtgccg gcagcagcct tctcagatgc gtgtgccaat gtacgaaacg gcttttcttt 3168481 tgttccttca ttttgatcac tgccatttgg cgaaacatac agataatccc cagatccttc 3168541 ctcattcgct tttgtcttat cataaacgaa agcgaggatg acagacgtta aaacacccgc 3168601 caaaagaata aaataccatt ttctcatttt cgattcccat ttcgttttag aatagatttc 3168661 taaaaccatt ataaatgttc tatttatgga aaaccatttc aaaaatatga aaatataccg 3168721 tctaaataga tcttattcag cctggcggac ctgcgcatgt tcaactgttt caattgccaa 3168781 tgatgcaggc gggtgaacac gcatcagaac aatgtagaaa agaaaggaaa tcagcacacc 3168841 tacaaaccaa gaaatatcgt ataagctctt caatacagga acatacatgc caatcagcga 3168901 aatcagcgct cctaacattg tggctgcaaa cgcacggtaa ttgtagccct tccaatacac 3168961 ataccgtcct gtttcggaat acaggtcatc taccgagagc tcacgtttgc gaatgataaa 3169021 atagtcggcc atcatcacgc ctgccaccgg tccaagcatg ccgcctatta agccaagaaa 3169081 cgcatacacg cttgtcgcgc tctccatcag cttccacgga accgtaaata aagcgagcaa 3169141 cgctgtgata aagctgccac gtttgaaatt gatatatttc ggcagggcat tcgctatatc 3169201 ataagcgggt gatacgatat tcgccgcgac atttacagag atcgtggcga tgcagagtgt 3169261 gatcacggac aagacgatga cataagggtt atcaaaccgc gccaaaatat cgacaacatc 3169321 ccaaatcggc tctccgaacg cgacctgcga gccggaggtc accgtaatac ttgcgaatgc 3169381 gaacagcgca aacgttcccg gcaaaccgta aaattgtcct ttgatttgct ctttttgtgt 3169441 ttcagcaaac cgtgtaaaat caggtatatt taagatcaat gtcgcccaga tgccgatgat 3169501 gccagtaact ccggcagcaa acggccagaa tgtttctgaa aacgtatgaa actttcctgg 3169561 ttgagagtat atcgggccca atcctccagc aatatcaacg gcccaccata ccatgccgcc 3169621 aaataccaga tacactaaag gccctgccca cacctcaaaa cgtttaatcg actccatgcc 3169681 gtgatgcaat acgagtaaat gaatggccca aaagaataca aaggaaagca aaccggacaa 3169741 gtgaatgccg agaatgttcc actcgccgcc aatttctccc caacctggcc acatattcaa 3169801 aagcaaaatg ttcagtgccg tgctacccgc aaaggtctgg atgccaagcc acatgatagc 3169861 tgtaaacgcc cttagaagcg cggggatatt cgcgccgtat atcccgtaag aagcccgaat 3169921 gatcactgga aacggcagcc cgtattttgt ccccgcatgg ccgtttaagg caagagcgcc 3169981 aaataggata agtgatgccg taataatgat cgccagcacc tgccaaggcg aaaggccgat 3170041 cgcaattaat cctcccacgg tcgcgtaggt cggtatgtta tgtatacatc ccatccaaat 3170101 ggaggcaaag ttcattgctt tccacgtccg tttttcctgt cccaaaggca ccagatcttc 3170161 attgctcagc ctgttggatt gctgctgact ctcttttaat ttcatagccg gctccccttt 3170221 ccatattgtc tatatgtcgt cacacgttat gttttttgac attagatgtc acttaatata 3170281 actgaagagt cagacaataa cactggctat gatatacaat tttcccgttt gtatttgaac 3170341 agcttaaaca agaaaaagag acagacctca gagcccgtct ctttcttaag atgcagtttt 3170401 cattaatgca gcaaatctca cagccattaa caggcttgct ccgcccgcta taatcataat 3170461 gattcccatc atatcaaaat gggctgccgt gatttcttta ccaaaaagaa tgccaaggat 3170521 caccgaagac aaaatcgatc ctaggtaacg gcaggtttga aacaggcctg aagtcgttcc 3170581 taccatgttg gaaggactcg tttccagcat cgctgcctga agcgcgacat tgcccagtcc 3170641 gtagcctata cccaagagcg acagaatgag gcctttaccg atggtctgga cattgataaa 3170701 aaagatggtt aagagcacgg ctccagccgt catcaaaagc gctcccgcaa agatcggctt 3170761 gacgacacca gatcggtcga tccatttgcc ggttagaggt gacacaacga tgctcattcc 3170821 agacataaac agcataaaca ggccgctcgt ttgaacagaa agatgcattt catcctgaaa 3170881 gtaacttggc aaaccaaaaa ataaacaata gaagaaaaca ttcaataaaa taaactgaac 3170941 atacacggct gacaggtttc gctgtgtttt aaacagacgg acatcaataa acggcttatc 3171001 cgttttcagc tcgcgccaga caaacgcaca gagcagaagc aagccaagca caccttcaac 3171061 cgcatgcggc gacgtgctga acgacagcaa aaaggataga aggaaaatga ttcccccggc 3171121 aaataaaaca attccaagaa tatcgagctg ccgaataatg gttttgattc ctgccccttt 3171181 tttctgatct ttcgggaaca tatacaggcc caataagaag ctgaggataa taaacggcaa 3171241 attaacgata aagatcgccg gccagcctcc ccatacaatc aaaaacccgc cggctgtcgg 3171301 ccccagcgcc gtcatggcgg acgcaaaaat agagagtaca gccaaggctg aagcttggcg 3171361 ctcatgaata tgattccgaa tcaagccgac acctgacgga taaatcgcac tgctccccac 3171421 cgattgaaac agccgcatga ccaataatgt cataaacgtc ggcgcaaacg gcgccccgat 3171481 ggcagaaacc gcaacaagaa taagcccgaa taaaaacaag cgtttccgcc caatcaaatc 3171541 accgagcttt cccgttacgg gctgcgctac ggcactcgcc aagtaaaacg aggaaatcag 3171601 ccaggaaacc gttgtaaacg agaggtgaaa ctcatgctgg atgctatgga gcgcaagaga 3171661 gatcatagac gagttcagcg gattcagcat tgttcccgaa gccacagctg ttaaaaaaac 3171721 agctcggctt tttttcgata acatcatttc acttgttcca gaaactcttc cgttgtccgc 3171781 gatttaccga ttctcgggaa aataaagcgc agtgtggctt catgctcttc atcgctaaat 3171841 gtggacatgg catctgtaat aaaaatctgc tgatagccaa gctgaaatgc ctcccgtgct 3171901 gtgctttcca ccccgatatt cgttgcgatg ccgcacaata caatcgtatc aatgccgcga 3171961 cgtctcagct gcaagtctaa atctgtgcca aaaaaagcac cccattgccg ttttgtcaca 3172021 gtataatcgc catcctgcac accgatttcc ggaacaaatt cggcccagtc cgccggcatt 3172081 tcccctgaac ctccctgcgc aggctcatcc gtttgcggct tcagggcgtc cgctccatca 3172141 tgaaaggcta catttacaaa gctgatgaac ccgttatgtt tccgaaattc atctacgagc 3172201 tttttcgcgt tcgggacaac ctggccgctt tgatcaatcg gcacaattcc cttttgtaaa 3172261 tcaatgataa ccaatgctgt tttttgaaaa tcaatgttga gtgtattcat catacgtctc 3172321 ctcctgatac tgttagtgtt tctcacattg catattttac tcttcacact gcctaagttc 3172381 ttttatgatg cttgtgaaat tctcagaagg agcgttttct catgattttt cttttatgta 3172441 gtagtaacag gttgtgcata cgaacaaacc ggcaagcact gtaatcataa agggcgtcat 3172501 cgcttcatca cctgcctgct gtctatcggt tcctgcctga aaatgcccat gaatttgcgg 3172561 cggtccatcc aaagcaggat aagacacata accattaata tcgtgctaag atcctgcacg 3172621 ccaatatcaa aacaatagtt aatcaagacg atgttcacaa taatgggcat aaaaataacc 3172681 gcccctaatg cagccgttcg cggaatcagt aataaaacag ctgccaggat ttcaccaaaa 3172741 cctataaaca gttcatagac atgagaataa ccgaaaaatg tccacgcgat cgtaaacccc 3172801 ttcccggcag ccgcctcgat ttcaggcgtc acctcgccaa actggccaat taccactttc 3172861 gccagaccgt acacgaaaaa attaaaggct aaaaacaatc ggaacgtcgc gggaatcgac 3172921 ttgcgtaccg ctttcctcag cctgccgcct ttattcatca tacatccccc tcagtgtatt 3172981 atttgatgta gtacacttaa tacagtatag agtattctaa ttaatgtcaa ttcccttttc 3173041 agctcatatg aatagtttct tttatagata caaagtctta tatcgcaaaa aatgccattc 3173101 tccttccttt ccatccctcg ataacatttc tcaaaaacca tgtcaggaaa tcttacatga 3173161 aaatgtttta tcattctttt ttctctataa tgaagaaata taataattgc tttttattct 3173221 gaaagatacg gaggaatgag acatgcaaat gggcgataca gtttttatgt tcttttgcgc 3173281 tttactcgtg tggctgatga ccccgggatt agcgttattt tatggaggaa tggtaaagag 3173341 caaaaatgtg ctgagcactg ccatgcacag tttctcttcc attgccatcg tttccatcgt 3173401 ttgggtgctg ttcggatata cacttgcctt cgcaccaggc aattcaatca tcggcgggct 3173461 ggagtgggca ggcctcaaag gggtcggatt tgatccggga gattacagcg ataccatccc 3173521 ccactcgtta tttatgatgt tccaaatgac gttcgccgtt ctgactacag cgattatttc 3173581 cggggctttc gcagagcgga tgcgattcgg cgcttttctt ttattctcgg ttttatgggc 3173641 ctctttggtt tacacacccg tagcgcactg ggtatggggc ggcggctgga tcggccagct 3173701 tggagcgctc gatttcgctg gcggcaatgt tgttcatatt tcctccgggg tggcaggact 3173761 tgttcttgcc attgtgctcg gcaaacggaa agacggtaca gcgtcttctc cgcataacct 3173821 catttacacc ttcttaggag gagctttgat ttggttcggc tggttcggct ttaacgtcgg 3173881 cagcgcattg accttagatg gtgtggccat gtacgcgttc atcaacacaa acaccgcggc 3173941 tgcagccggg atcgccggct ggatcttagt agaatggatc attaacaaaa aaccgacaat 3174001 gctcggagcg gtatctgggg caatcgccgg gcttgtcgcc attacgccgg ctgccggatt 3174061 tgtcacaccg ttcgcttcca ttattatcgg catcatcggc ggagctgttt gtttctgggg 3174121 agtattctcg cttaaaaaga aattcggata cgacgacgcg cttgacgcct ttggcctgca 3174181 cgggatcggc ggcacatggg gcggaatcgc aacaggatta ttcgcaacaa cctctgttaa 3174241 ctcagcgggc gcagatgggt tattttacgg tgatgcaagc ttaatctgga aacaaatcgt 3174301 cgccatcgcc gccacttatg tttttgtatt tattgtcact ttcgttatta ttaaaattgt 3174361 aagcctcttc cttccccttc gcgcaactga agaagaagag tcacttgggc ttgacttaac 3174421 gatgcacggg gaaaaagcat atcaagattc tatgtgagga gtgacgctat gagcggtcaa 3174481 atgttcaagg tagaaattgt aacgcgtccg gcaaattttg aaaagctgaa gcaggaactc 3174541 ggaaaaatcg gagtgacctc tctgactttc tccaatgtac acggctgcgg ccttcaaaaa 3174601 gcacatacgg agctctatcg aggggtaaaa atagaaagca atgtatacga gcgtttaaaa 3174661 atagaaattg tggtcagcaa ggttcctgtt gatcaagtga cagagaccgc taaaagggtg 3174721 ctgaaaacgg gatcaccagg tgacggtaaa atatttgtct atgaaatcag caatacgatc 3174781 aacatccgca caggcgaaga aggacctgaa gcactttaat atcggtacga gattcggaca 3174841 ctccggatct ctttttttgt gcacagaatc cccccagaaa ccgcgattcc tcttcgaatt 3174901 ctcttcaagc gccgttattt cagacaatct ctatttttat ttgaaacttt tcatgagtaa 3174961 gattagtcta ctaaatataa aaatgtaaaa ggtgattatt tgaactacga aatttttaaa 3175021 gcaatccatg gactatctca tcacaattca gttctcgatt ccattatggt cttcatcacg 3175081 gaatatgcca ttgtcgccta tgcccttatc ctattggcaa tctggctgtt tgggaacaca 3175141 caaagcagaa aacatgtgct atacgcaggc atcacaggaa ttgcaggcct tgtgatcaac 3175201 tatttgatta cgcttgttta tttcgaaccg cgcccgttcg ttgcgcatac agtgcataca 3175261 ctgattccgc atgctgcgga tgcttcattt ccaagtgacc atacgacagg tgcattagcg 3175321 atttctattg cgatgctttt cagaaaccgc aaaatcggct ggccgcttgt catttttggg 3175381 cttttgacag gcttttcgag aatttgggtg ggacatcact atccggtaga tgtattgggc 3175441 agcctcgttg tcgccatcat tatcgggttc cttttcttta gattttcaga tctgcttcgc 3175501 ccgttcgtcg atttggtcgt gaggatctac gaagccatta tcaataaact gacgaaaaaa 3175561 ccaaccgatc aaaatttcta agaaagacaa aagccggcgt ctgaaatcaa gacagccggc 3175621 tttaatattt ctcatacatc tcttgttttc ttcgcttcgc caacacatat aaaccataaa 3175681 acaacccaat tccaacagca tcgatgagca catcccggat acaaccattc ctgctgaaga 3175741 agagctgaag aacttctgtg aaaaaagcaa acgcaaatga gccggctgca gctgatctta 3175801 tgctgccccg ctgtttccac agcaaatatg tcagcacaaa gaaggaaaac gcgtgtccga 3175861 ttttttgaat aaacgcttca ggtacagtaa gctcagtaaa atccataact aaaaattgag 3175921 acagatcagg gtgcggctga aaatgaaaag ccaccgtttg cgatacgacc atgccgctga 3175981 agctttccgt acagacagaa agcaggataa aaaagatcca gcctgcgagc aataggcggt 3176041 tcatgacata acctccttta taacgtacgt gcctacatgt aactacatag acggtaaaac 3176101 aaagcaaaaa gtaacagaaa aaaacgccca tcacaaggat agacgttttc ttcattaaga 3176161 ctgttcagtg tcttctgttg tgctgctttc tttagaacca gatttgtcag ttgaatcatc 3176221 ctttttctca ccggattttt cttctgttcc tttttcagtt gatccgtcct ttttctcgga 3176281 agattgctga atggattctt ctgtttcttg ggtggcagct ttttcaatag aagaaactgg 3176341 tttgtccata aagtttaacg gattcattgc aaccccatct ttacggattt caaagtgcac 3176401 gtggtttccg ctgtcttcac tgtaaaggtt cttgccagat tttccgatca cttgattttg 3176461 ttttactttg tcaccttgct ctacgcttac ttcggaaaga gattgataca cagtcgataa 3176521 accgtcggca tgttctactt ccacaacata tcccagcact ggatcttttt cagctttaac 3176581 aaccgtaccg ctcagagaag cagagacatc gaaatctttt ccgtctttct cagctaagtc 3176641 aattcctttg cttaggctgt acgtgttatt ataggtaacg agtgctgctt ctttctcttc 3176701 ttttgcggca tcggtttcat agaacttttt cacaacagaa acgttttcag aatcaacaac 3176761 cggcattgcg acattttcca ttgactttcc tacttcaact gcatcgtcgt tgttgtcata 3176821 tgcggagttt ccgccgttat cagccaactg atcctttacc tcatcatttg atactgattg 3176881 ataccaaagg acagctgtta aaatgacggc cgcactgact aagtaaattg cagggaacac 3176941 ccagcgttta cgaaaaaact gctgaagttt tttgacttga gaagttttct tttcttcctc 3177001 tctcattgtt tcatcacctc agcaacattc tgaacacttt tctgaaaata tatacaacct 3177061 atccaaaaaa acttttttag atgtagtttg cacagactga acgaaaatat gtattttttt 3177121 gagaggagtg ccaaaaacgt atgaacatga cattgcgtct tgctgaacat agagacttgg 3177181 aggctgttgt ggcgatttat aattcaacga ttgcttctcg aatggtaaca gccgataccg 3177241 aaccggtaac tcctgaagac cggatggaat ggttttcggg acatacagag tcacgtccgc 3177301 tctatgtggc cgaggatgaa aacggaaacg tcgctgcctg gatcagcttt gaaacatttt 3177361 atggaaggcc agcctataat aaaacagcgg aagtcagcat atacattgac gaagcatgcc 3177421 gcggcaaagg tgttggatca tatttgcttc aagaagcgct ccgcattgcc ccgaatcttg 3177481 gcatccgctc acttatggcc ttcattttcg ggcataataa accaagcctg aagctgtttg 3177541 aaaagcacgg gtttgcagaa tggggactat tccccggcat cgccgaaatg gacgggaaaa 3177601 gatacgattt aaaaatttta gggagagagc tttcatgatt agtctggata aagatgaaaa 3177661 cgaaattgaa catcataatg aagaaaatag ccttgttgaa caggagactg cacctgttgg 3177721 acaggagagc cgccagctga gcgcctccgc tgtcaagtcg ctatccgaca ttgccaagtg 3177781 gggcaaaatt tctggcatct tgttaatcat tatgggatcg cttgtcactc tgtctgtttt 3177841 gatgacagtg attggcgcca tcccgggcgt actgctcatt atttcaggcg tatttttgat 3177901 gcgctcagca aaagcagccg cggaagccga aggaaatcta accggcagcg ctggcgaaag 3177961 catgcttgaa aattacggga catttataaa aatgcagctg ttttatgcag catccagtat 3178021 cgttactgtc ctgatcggga tcattgtagc cattttcgtg ctggtggtaa tcggcattgc 3178081 tgcttttgag aacacgcctt cgtatgatga tccggattct tattattatg aggatgatcc 3178141 ggtgtttgaa taatgatgag acaggacagg gcatgagttc catataaacg gaaccatgcc 3178201 tattttattt gactattcaa agcaggccgg cgtaaacacc aaatcctgaa gcaagcatac 3178261 aatagacatc tctagtagag gaaatcaaca aagcaacgct gttacccaga aatgaatatc 3178321 aaaaaaacgg atgaagtcgg aatcaatccg aaaccgcact ttttatttcg ggtgtctgca 3178381 tgcaaaaaaa cacacccgga tcgtctggaa aatctcaaca atccgggtgc agatcttctt 3178441 taatacattt ttttgcgtct gtcttcctca gtcaaaaatt caacaaaact ccgcatcgca 3178501 aaaggctctt cctttatttg tcgtgcgtag gagcttttcc gctcttctga aaggatttcg 3178561 ctctttttga tcctgttcag catatagatg tgaaccgttt tttggatttg tttatgctga 3178621 tagcctgcct ctttaaaaaa tgcgagcccg agcgccgcca aaagggcgaa tatgcctgcg 3178681 ctgatcaggg actccctgtc agctgaagca tgaaatagaa aagcagctaa attaaagaga 3178741 gagaatgcag caagcggaat agcaagaaaa cggtaaatga cggttttttt catgaaaggc 3178801 tgtacggcct tttgaatttt ttgcatttct gttttgatga accccggcat ttgttcgact 3178861 ctgtaaaagt tcatataatc ctcccccttt atttgatgtt tcaagcttca cgaacgttat 3178921 catatgtgtt tattttaacg caggtgcaag ctggttttaa agaaatctgc ccgtattttt 3178981 cacgaagaat ctggatcgcc gctctttatt cttttaaaat gtgagtgtta taatttgtaa 3179041 tgggaatcag atcactgtta ttcatggaat actaatggca atcttcttga taaatatgaa 3179101 tgagcggggt tacaaagtga gtatttcttc catcctttta tcactttttt tcattttaaa 3179161 tattcttttg gccatcattg tcatcttcaa agaacggcgc gatgccagtg catcttgggc 3179221 gtggctgctt gttcttttct ttattcccgt tttaggcttt attttatact tattattcgg 3179281 ccataatctc agacgcaagc atttgtttca atgggaagac cggaaaaaga ttggaattga 3179341 aaggctgctg aagcatcagc ttgaagattt agaaaccaag caatttcagt ttaacaaccg 3179401 ggcaaccttt gataacaaag atttaattta tatgctgatt atgaataacc atgctgtgtt 3179461 tacagaggat aattcagttg acgtcattac agatggacgg gataaatttc agcggctgct 3179521 gagtgacatt tcaaaggcta aggatcatat ccatttacag tattatattt ataaaggcga 3179581 tgaattaggc aaaaaattgc gggacgctct catccaaaag gcgaaagaag gtgttcaggt 3179641 cagagtgctt tatgatgaac tcgggtccag aacgctgaga aaaaagtttt ttaaagagct 3179701 tcgcgaggct ggcgggcatg tggaggtctt tttcccgtca aagctcaggc cgattaacct 3179761 gcggctgaat taccggaacc atcgaaagct tgtgatcata gacggtatga ccggttatgt 3179821 cggaggcttt aacgtcggag atgagtatct agggcttaat ccgaaattcg gttattggcg 3179881 ggatacgcat atccggctgc aaggaacggc cgtgcacgcc atccaaacac gattcatcct 3179941 tgactggaac caagcttctc atcaccatac gctgacatat attccaaatc actttcctga 3180001 ttacggccca aaaggcaacg tcgggatgca gattgtcaca agcggccctg attcggaatg 3180061 ggaacaaatt aaaaatggct acatcaaaat gatttcgaac gccaagcgtt ccattttgat 3180121 acaaacacct tattttatcc cagatgcaag cctgctggat gctttaagga tcgcttgcct 3180181 ttcgggcatt gacgttaaca ttatgattcc gaacaagccc gatcacgcct ttgtatactg 3180241 ggcgacactt tcgtatatcg gcgatctgct gaaagccgga gccactgtct atatttacga 3180301 taacggcttt attcacgcga aaaccatcgt ggtggatgac gaaatcgctt cagtcggcac 3180361 agcgaacatt gatgtccgaa gcttcaggct gaattttgag gttaatgcat ttatttacga 3180421 tatcaccatt gctaaaaaac tggtttcaac ttttaaagaa gatttgctag tatccagaaa 3180481 attcacctat gaggagtatc tgcagcgccc gttgtggatt cgaataaaag aatccgtctc 3180541 gcggctgttg tcgccgatct tataagatgc gtaaaccccc ggcctttacg gccgggggtt 3180601 ttcctgatgg tcacagtaaa tgatgattgc ctcccgcaaa aaagcggcaa gaccttctcc 3180661 atattgattg attgaatcgg taaatcgctc gtcagtgata tacacttccc cgagtcctct 3180721 gaaaatgtcg agtgtgcaat cgtaatgata ttggcaaata tgatcgcgaa atgcccccac 3180781 agcggcctga atctctgcat catcgggccc atgcttcatt cgcgccgcaa ttcgtctgta 3180841 aatcgaatca aattcagcca tgatcgtgcg ccaatcatct gccgagtatg cagatgtcct 3180901 tttctctgtt tcttctgcga tttcctttcc atacagcttt ctgacttcat cagcgtatgt 3180961 ctgctggtgc tcttcaatgt ctttcatgct taatccggca aataaatccc tcttattcat 3181021 cgtttcccct ccatcaacgg acaaaagcgt cctgtcaatt gtttgaatca tctcatccat 3181081 tctttgtttt ttcttcatca atatctcctt ttgcgactga agtgccgctt tccggtcaaa 3181141 attcggatga tccagcatct ctttaatctc atccagacga aacccgattt ccttgaaaaa 3181201 taaaatctgt tgcagtcttt ccaggtctgc gtcactgtac aaacgatacc cagcatcagt 3181261 aagcgctgaa ggattcagaa gctcaatatt gtcatagtga tgaagcgtcc gaatgctaac 3181321 gcctgatatc tccgccactt gtttaacttg atatttcata cataacacct cctctttttt 3181381 atcgtaaaca atcacgcaac gttagggtca atccccaaaa tgttattttc tatatacaaa 3181441 acttctcaca aatagtgtat aaaagaaaag tgagtatttt tttgtaaagg ggagccagta 3181501 tacatgaatc ctgaaacaat gaacaaaacc ctcatcagca tttcgaaatg gggaaaagct 3181561 acaggcattt tatttattat tatgggcgca attaccgcgc tttcaggcgc gttctttttt 3181621 ctaatcggtg ccgtgccagg cgtactgcaa attatttccg gtatcttttt gatgaggtca 3181681 gctagggaag caggccaaat ggctgaacac aatagcggac agtctgaaga cttaatgctg 3181741 gagaattacg cgaaattcgt aaagatgcaa gggatttatt tgatcgtaag cattgctgta 3181801 tccattcttg cgattatcgc cttcttcatc tttttaatgc ttgggattgc tgacggcctt 3181861 ttcagcgata cgtacagcac ttattaatga gaaaaacccg gagctggctc cgggtttttt 3181921 attattccgc ttcgcttacc actgtgaagc gttcattttt gtgttcggga tgttcaagct 3181981 cgtccaacac ggcaatggca taatctgcat agctgatata gctgtctcct tttgcattta 3182041 cgatgacatt gtcttttcct ttttggtaag agccagtccg ttttcctgct ggatcaaaaa 3182101 atgccgcagg actgaggaac gtccaggaaa tggagtctgt ctgctgcaaa tctttcaggt 3182161 tctcgccttg atttgatgca gttggcaaat attctttcgg aaattccggc gtatccatta 3182221 aacgggttgt tttggcttca tcaacaaaca ggcttcccgc tccgccaaca acaagcaatc 3182281 ttgtgtgctt cgcgtccttt aaaatgctga tgagtgctct tcctgcttca acatgaagat 3182341 gttcttggcc gggtgctgct ccaaaagcgt ttacgaccgc gtcgaaaggc ttgatgtctt 3182401 ccgcagtcag ttcaaacaca tctttttcca aaatcgctac gtcttgctcc tgcacttttg 3182461 aagcgtttct gacgatggct gtcacttcat ggcctctttt tttcgcttct ttcaaaatct 3182521 cgtttcccgc tttcccgctt gcgcctataa taccaatttt catttttcat ttcctcctta 3182581 tttgtaacaa ttttagttac atgttagcgg tgagaagtca tcccttttga ttaaaagaga 3182641 tgattcataa catcttttaa tgacttgctt gccagttcat tttccatcgc tctttgcaca 3182701 ctttcaaacg tttcatccag agcgttctga atttttttcc ctaccggaca tttcggattc 3182761 gggttttcat gaaccgcaaa gagttcttct tgcttttgga cagcccggta cacttctaaa 3182821 agagaaatat cagcaggatc ttttttgagg cttgcacccg gcaccccggc gcgtgatgtg 3182881 agaatatcag cttttttcag caggctgatc attcttcgca caactaccgg attcgtgttg 3182941 acactgtctg caatgatttc tgaagatgtt ttttcatcca tcgagatgag ggataaaata 3183001 tgaatggcaa cagcaagacg gctgttaatc atgttttttc accaccgttg taactataat 3183061 agttacattt gattcgtttg tcaacatcta atatacacta aatacatggg ttttgtgcac 3183121 cgtttttagt caatagaacg gccggatgca ctccggccgc gtcttatcaa aataagaaat 3183181 atctttgtcc aagtgggaca taatcgacag gctggcaaga caattcctcc ccgtcagcaa 3183241 agacctgata ggtttttgga tcaatctcaa tcttcggcaa agccgaattc agcttcatat 3183301 ccagcttgct cagctttctg atatttttga ctggagaaat ccttttttcc agccctaagc 3183361 tttccgccac accacgctct atgcttgcct gagacataaa tgtaatcgag gttgagcggt 3183421 tggcttttcc gtaagacgca tacatttggc gcatgaaaac cggttcagga gtcgggatgg 3183481 acgcgttcgg atctcccatt tgcgcacgtg caatcatgcc gccctttaag accagttccg 3183541 gtttcacgcc gaaaaatacc gggtcccaca gaacgagatc agcaagcttc cctttttcca 3183601 ccgagccgac ctcatggctg agcccgtgcg taattgccgg attaatcgtg tatttggcaa 3183661 tgtaccgttt tgcgcgcaca ttgtcattcc cgttttcacc ggcaagagcg ccgcgctgtt 3183721 ttttcatttt atcggctacc tgccatgttc ggatgatcac ttcaccgacc cgccccatcg 3183781 cttgggaatc cgatgatgtc atgctgatcg cacctatatc atggagaata tcctccgcgg 3183841 caatcgtcgc cgccctgatt ctggaatggc tgaatgccac atcttcaggc actttcgcat 3183901 ctaaatggtg gcagaccatc atcatgtcaa gatgctcatc catcgtatta acggtataag 3183961 gaatggttgg cgttgtagat gacggcagaa tgttcgcgta agaggcgagc ttcataatat 3184021 ccggagcgtg accgccgcct gccccttcaa tgtgataagt atgaataacc cggtccccga 3184081 tcgcgtcgag cgtgttttcc aaaaagcccg cttcgttaat cgtatcggta tggatggcaa 3184141 cttgaatatc agcctcgtcc acgacttcca tacacgtttt aatggcgctt ggcgtcgttc 3184201 cccagtcttc atggagctta agaccgatgg cgcctgcttc cacctgctcg atcagcggcg 3184261 ctttatcgga tgcattccct tttcctaaga agccgacatt gatcggaaac tcctcggccg 3184321 cttccagcat cctcgccata taccacgccc cggacgtaca tgttgtcgct ttgcttcctg 3184381 tagcgggtcc tgttccgcct cccaaaaggg tcgtcacacc tgaagaaagc gcaacttcca 3184441 tctgctgagg acaaataaaa tgaatgtgcg tgtccactcc cccggctgtt aaaattttgc 3184501 cttcaccgga aatcacctct gtccccgctc cgatgaccat gtgcggatcg actccatcca 3184561 tgatatcagg atttccgctt tttccgacac cgacaatccg gccgtctttc acaccgacat 3184621 ccgctttgac aatgcctgtg taatccaata gcacgacgtt ggtgataacc aaatccaaag 3184681 cgccgtcctt ccctgtgatt ctgccgtttt ggcccatgcc gtctcggata gtttttccgc 3184741 cgccaaagat catttcttca ccgtatactg tgaaatcctt ttcgacttcg atccataaat 3184801 ccgtgtcgcc caatctgatt ttatcgcccg ttgtcgggcc aaacagttcc gcatattcct 3184861 cccgtgacat tttcatcgga ttacaccctc catccagccg gcttgtttta agttggccaa 3184921 cgttttttct ttgccgcgtt catcgataaa cgtgtcggcc attccgttca gccctctaat 3184981 tgtcttgcgt cctctgattt ccactagtga gaccgttttc tgctctcccg gctcaaaacg 3185041 gaccgacgtg cctgatggaa catcaagacg catgccgatc gccagctcac ggtcaaataa 3185101 taaagccccg ttggcctccg caaaatgaaa atgcgaaccg acttgaatgg agcgtgatcc 3185161 ggtgtttttt accgttacct cccgtatctc acggccttca ttaatcgtaa tggttccctc 3185221 agcaatttga aatgctcccg gcttcatgac ttcacctccg cagaaattgg ctgatgtacc 3185281 gtaacaagct ttacaccatc cggaaatgtg gcctccacct gaatgctgtc cagcatctca 3185341 ggcacaccct ccatcacatc tttttccgtt aatacatggc ggccggcttc catcagctct 3185401 gctactccct tcccatcacg tgcgccttcc ataataaagc aggtgatata agcagcagcc 3185461 tcaggatagt tcagcagaac gccccgcgcc tttcgctgtt tggctaattc ccccgctgca 3185521 aaaatgagca atttctcttg ttcaactggt gtcagtttca tctgtagtcc tccttctttt 3185581 gtcatataaa gcagatgcgg ctactacgaa tttgcggaac agtcaggcgg gacatcacct 3185641 ccctttcttc gagaatgggg gtcatacggt aagatgcctt tcaaagcggc atgccgtttc 3185701 ttcatcagcc ttgccatggt caacaaccgt tcccctgtcg atcacggaaa gatcagatta 3185761 acgcgttttc cagactgcgc tcgactaaga taacaaatgt ctttttttct ggaaatttct 3185821 ataataactt gtctgactag ttcgacaatt aaaatctgaa ttccttccaa ttgtttatta 3185881 agtaaaatat ttttcagatt taccatcagc gctctggtga ttgcaagctg ctgctgttga 3185941 ccgccttttc gttttgaaca aacgtttgat taaaacaaat agccccctct gtttagccgg 3186001 agtcggccta atacagcgac aatctgcccc gggcgaagct aaggctgtgc aaaaccatcg 3186061 attgatcata accagacgtt acattcctga tggcagcccg ttgttttgct ccgcaaccgg 3186121 aagcatggca tggaggccag tctgaggcgc cgacctccac gataccgaga acccgactat 3186181 tgccattaac tccgcatcat ggacggtcac ttcgctgatc gccaccgttc ctcttaatga 3186241 gtgaagaatt ccggccttca ctgaatcccc gcttgtgtcg atatcaactg ttttctcgca 3186301 ctcccgtggc ttccgacact ttcttcggtg cagtacattc cgtcatcaaa acccctttgt 3186361 ttgatttctt caaatgatgt tataaaagtt tacaacttat gtcatcatta tatagaagag 3186421 gcctattaat tcaaagaata tttaaaaaat ttagttacct tgaccaaatc agcttctttt 3186481 tttgttatat ttattcacat cagaaaaagc gaaaaaaaaa gacaagaaac atttcgtttc 3186541 ctgcctcttc cgtacgatta atctttatct gaaaatttat ccttggcttt cccgatatcc 3186601 ttttggattt cgccttttgc cttatctttt ttgccttcag cctgcatgtc cgttctgtca 3186661 gccatatctc cgactttatc cttcacttct cctttggctt tattgaagcc gcccttcatt 3186721 ttgtctttta cactatcgtt acccatgtta attctcccct ctcaattatg tgtgtacttg 3186781 ttaacttccc gatctgagag gcaataaaca ttctaatgtt atttatcgat ttcgtagcgc 3186841 tctccgtaac ggagcacctt gtatatcgcc agcccgtctg atgacttttt ctccgaatat 3186901 cggaccggca gcagggcaaa aaacacataa tacgtagaaa aatagacaaa ctgatagaaa 3186961 aacacattcg gctttaatac actgtgtata atcagcagat tgattgcaaa aatcgtgatg 3187021 aggttaaaca agcagccccc tgcatacacg agtgcatttg agaatcgatt gtcaattttc 3187081 aactccccgt accggcaaaa agaatcgata aaataaatcg ttctgaaccg tatgggtcca 3187141 attttaagca gcgtttttcc catgcctata tccaacgatc cctttccgcc aaaaataaaa 3187201 gccataaagc tgtgccctga aacatgtata atctgtacaa gcggcagaac aatgaggaaa 3187261 gaccacagaa acttcaccat atcattaaaa ccaaacattg aattccccct cacatgcata 3187321 tctgcatccc aaaacggctt ttgttcaaaa aacagtgctg tagcgatttt tcctgttctc 3187381 cccggaaata aacgttccga tgctcccctt tttttgcata aaaaaaaacc atctgccagc 3187441 agatggtttt gtctcatact tcatataaac aatcgttcct ttgaatcatc tctctcatgc 3187501 tgaccgcttt ttcataaaaa tacaccgctt ctttatattg ttcgcgatga ctgaaataag 3187561 aggcagcatc taaagcaaat tcttcaatat atacatacag gcccttttct tccatataat 3187621 caaatacttc ttgaatcata ttcaaattga cagattccac atataatgcc tgcagaaatt 3187681 tatattttgc cagactgaag aagtcgtttc gtttttgggc aatggcaatc cctttttcat 3187741 agtaccgtat cgcggcttcg ctatcttgtt ttttgaaaag aacgcgagtc aggctgaaga 3187801 gcgcttttgg aagctgttcc agctgataat cctcgaagac aggaagcgct ttttcaaagt 3187861 attcggcggc ctgatccagc tcccccttgt catcatagca attaccaata ttataaaggg 3187921 ctgatccgat caaacggggc tgtccttcca ataaagcaag gcgatacgcg tcatctaaat 3187981 gttcaagcgc tttttcataa tttctgtagt caatgtagtt tcctgatatg acgaaatggc 3188041 attgaattct tctgactctg taaaaatcgt gagccttata cgtctccagc gcctgtacgg 3188101 catggttcat ggaaaagtgc gtctgcttca taatataaaa gacttccgcc actttaaaat 3188161 gaaattccgc tctttcaatt tcatcttcta caaacgcaag catcttctca gctttccgat 3188221 aaaaggatat agccgagatg taattgttct gttcaaattc gtacattcct ctaaacaagt 3188281 gaaaataata ctcagataat ccggagatgc tgtcctgatt gctttccagc gttttgatca 3188341 attcacgata ttgaagctga gattcctcgt gcaggtcagg ctttacataa tccagcataa 3188401 tttggtgccg gtagctgatc agctgataat acaggagaag cagctgatcc tcttccatct 3188461 gttcgatatc tagatcaatt tcttctttca gttttacggc atcagccact tgaaatgcta 3188521 aaatgtgctt ataccactta ttgattttca ctcctacttg agatgacggg atctcgtacg 3188581 cggccatgcc cctccaaccc tttctatttt ctaattggtt atattttatc ataatgtatg 3188641 gctttggaat taaattttct tacaatgatt ccttctttat gcctatcctt atatatttcg 3188701 gtttttctac gtattttttg cactcggatt ctaataaaaa agcttaccgg acagtgccga 3188761 taagcttttg acttcaaatt aaccgccaat ataagacatt tccactttct ttttgccaga 3188821 tgcttttgat agcgtacgat cgactgaata ctgatcgatc cgatttttcc atactgtccc 3188881 gatcatttct gatagttcgt catcacttaa ttcctggcga accggagctc tgaggtcaaa 3188941 tccgcttgaa gcgaataagc aggtaaacag ctctcctctc gcagaaagac gggctctgtt 3189001 gcaagatccg cagaatgcat cagatacaga tgatatgacg ccaatttctc cggagccgtc 3189061 caagtagcgg aatctggaag ccacttcgcc tatataatta ggcgctatcg gctcaaccgg 3189121 catgtgttta ttgatcaaat ctatgatttc cgcctttgtc atgacgtctt tcttttccca 3189181 ttggttggtg ttgcctacgt ccataaattc aatgaatctc aggatatgcc ctttttcttt 3189241 aaaataacgg gccataggca gtatatcttt ttcattgacg cccttttgaa cgaccatatt 3189301 gattttaaca ccgagccccg cttgcttcgc cgcttcaatg ccttccagca ccttgctgac 3189361 agaaacaccg cgcccgttta tcttcttaaa acgctcgtct tctaaagaat caaggctgat 3189421 cgtaaccctt ttcagcccag cctccttgag cctcttagca taaacaggca gcagtgatcc 3189481 gtttgtcgtc atcgcgatgt cacgaatacc cggtatgcgg gccagttttt tgattaattc 3189541 cggcatatcc tttctcatga ggggctctcc gccggtcaag cggatttttt caacgccaaa 3189601 tcttgtgaca aacaatgtcg caagccgttc cagctcctca aatgaaagca gctcctcttt 3189661 ctttaaaaaa ggataatccg ggccgaataa ttcggcgggc atacagtacg tgcatcggaa 3189721 gttgcagcgg tctgtaacag aaatgcgaag gtctctcagc ggtctgtttc ttttatccaa 3189781 catctgacgc gactctgtaa tcatagctac agccccttcc tactccctga ttctctcagg 3189841 gtgtgtatat acattaaatg atccgtttct gacaaatcca atcgctgtga tattcaattc 3189901 ttcagccatt tgaatcgcaa gctccgtcgg ggccgatttg gaaatgacaa tcgacacgcc 3189961 gattttggcc gcttttaaca ggacctctga tgagattctg ccgctgaaca caatcagttt 3190021 gtcgcgtacg gacatcccgt ttagaaggca gtgtccgtat agtttatcaa gtgcgttgtg 3190081 ccgaccgata tctgtgcgca tcaacagaag cttctctgtg tcgcaaagcg ccgcattatg 3190141 gacgcctccc gtatcctgaa acgtcccgct cccttgctgc atgtctttca taagcgccag 3190201 acatgcctca ggcgatatct tgatttggct gacagccgtc ttggctgttt tgacatcctg 3190261 ctgaaaataa aaatgacggc cctttccgca gcatgagccg atcacccgtt tcgtataatc 3190321 cttttgatcc aatgtctcag ggtgaacgag gtcgacatat acaaaaccga gactttcatc 3190381 tattgtaaac cttttaattt ctttttgaaa tcgtataaca ccctctgatg cgagaaatcc 3190441 gatgacaagc tcttcgatat gctcaggcgt acaaacgagc gtcacaaatt cactgccatt 3190501 cagtatcact gtcaaaggga attccgtcac catccggtct tctactttgc ttatttcccc 3190561 ttgttcatag cgccatacat ccctgaccgc agttacttta tcgttcaatg tctcttcccc 3190621 tccgcaatgt tcctgccttt atattttttc acactcctcg gattttgtcg aattctgaga 3190681 cacaaaaaga gccctctata taaagggctt ttacaggatg tgatgacggc ggtgtttagg 3190741 caggacgcct aagcatttag ccgccgttcc ttttataaca cgtgagcacc aatgtgcatt 3190801 gacaacgaac gcggggtttg tcgacacgct gagacacctc tgtataaagg actctatgtt 3190861 tgattatgct gattcttttt cagaaccgta aacagcacaa tagctgcgat caaggtgaga 3190921 atgctgacaa aaaagaaggc tgccagtttt agaagaacac caagcaatat aaatgcaacg 3190981 gtggctataa gaaaaatcat tccgaataat ttcatatgtt caaccccttt ttagggtatc 3191041 attcccgccc aaactgtttt taaaccaata aaaaaggcgc ctgggggagc gcctgatctt 3191101 taggttcctt actcagtaaa tttttgtgct tctttttccc aagcctgttc gaactcatcc 3191161 gcactgttcg ctgaaatata ttctccgccg ccagcgacag ctgcttgttt catctcttca 3191221 ttacccttga catcaaagtt gaagccaatg atgtttacaa tcgtatccac atttgatgca 3191281 cggagctttt cgatttccgc cgcagggtct ccgccgcacg tttcttcacc gtcagtgatt 3191341 aaatacacca cgtttttccc gtctgcgtca aatgcttcaa attcttttct tgtgtctgca 3191401 agtgctttgg caatcggtgt ccatccagtc ggcttgagct cactcaatga attgtcaaac 3191461 agagaccctt catatggatg aaggccgtaa atggtttccg tcgtactgca cgaaagggct 3191521 ttaccggaca gtttattgtt ccctgcatgc ccgaaaacgc gaagcataag atttgtatcc 3191581 tttggaagaa gttcggcaaa agattttact gattttttgg caatgtctat tttgcgctct 3191641 cctcctgttt tttgaaccat gcttccgctt ccgtcaaaca aaacagctac atttgtatca 3191701 gcctgtttct cagcggcaaa agacggggag gcaatggaaa cagtcaacaa tccaatgata 3191761 ccggcagcca gcaatttttt catatgatta cttcctttct ttttcatatt ttccaactat 3191821 atgttggatt cttctttatg ctagaatacg aaaatgcaaa aagatatagg acatgctgcc 3191881 ttttgtgctg ctttcacgat ctgtccaaaa tcgcttgaaa tgccgttcat ttttagccat 3191941 ttccgcccag aaagcataaa cagcttgtgt gatcattcat tcttttttcg ccttgattat 3192001 gacagaaaaa cggaaatctg ctactatgct acaggcagac agctaattag ttttgaagtt 3192061 tttgttacat acaaaaagag gctgaccatc accagcctct tttttcttat ttagataaca 3192121 ttagtgattg ctgagtgaaa attttctcaa catctttttg ggtataagcc gggaagtatt 3192181 caccgccgcc tactttcgca attgcgttca gctggccttt gtatccctct ttataatcaa 3192241 agccgatcac attaacagtg atattgtctt tttgcagttc ctttgctgtt ttaatcgggt 3192301 ttcctccgca cgtttcctca ccgtctgtca acagatacac cactttttcc ccttttgcat 3192361 caagctggtc aaaagaagat ttcgcctcgt tcagcgcttt ggcaattggc gtccagccag 3192421 tcggcccaat tgtattgaga gaattgagga agctttgctc gttaaagctt tggaagccgt 3192481 atacgttgcg aatggcttca catgactgaa cttttccgga atttttattg tttccttcag 3192541 agccaaacac gctcattttc acctgagttc cttctggcaa tgagctcgca aactttgaaa 3192601 tttctttttt ggctgaatta aatttagata caccatctat tcttttcgcc atacttccgc 3192661 tggcatcaag caagaccgcc acgttcgccg gcgctttagc ctccgtttct gtcttttcag 3192721 ctgcaaaagc aggtgaagtt aatccaaaaa gcaatcctgt catcatgatc agtgaaaatc 3192781 ttttcttcat gttcgtaccc ctttaccaat ttgtttctgc gtgcagatgt tcaacgctga 3192841 acataatcta tcgtaatcaa caaaaaccga gaaataaata gggcgggctt ccccattgct 3192901 gttgtttact tttgcataga aacctatgtt tttattagtg atttccacct aacgccccta 3192961 tgaaaagaga agattgtccg cctttcggct ttcgttatat gagtctgtcg aagtctgtcg 3193021 acaaatgtgg atgactttac cacaatctca aagcctgaaa tcaggaaaaa aggactgatc 3193081 cttaaagacg gtcagaagct cctctaaacc gtttcagcta ctcttagata aaagatattc 3193141 aggaacagaa aaagacgccc aatgagcgtc tttttctact ttttcgccat atatttattc 3193201 aaaaacgcat ctgcctcaga aatttgtgtg ccttggtaat agtactttac aatgtcatca 3193261 accgttttgc cttctttggc cataaaattc gctccgtatt ggctcatccc cacaccgtgg 3193321 ccaaatcctc tcgtcgtgac tgtaattgtg tctccatttc gcttccattc aaaatcggcg 3193381 gagttgagac ccaacttttc acgtatgtct cttcctttca gcgtcttgcc gttaatgacg 3193441 gcagttgcga cctggtggcc cggtgtctcg ccggtaatct tccctactgc gctagatcca 3193501 tccagcttga cgccaagctt ttgctgaaat tctgccgctg taaaggtttt cgttgcctta 3193561 tatttcggag actttttatc ccatgggctt ttgacgcttt ttaaatatgg gatagcactt 3193621 gtccaataag cttctgcatt ctctgtgtag ccgttgcttg tggagaaaaa ggatgcttca 3193681 atcggctggt tgttgtacgt taagattttg ccttgcgtac tggctaccgc atctgtgatt 3193741 ttcttcagtt ttgtctcata gcttgtgccc cactgttttt tcagctccgc tttgctttta 3193801 tacacctgga acatctgtgt atcatccacc agtgagcctt taggagcttc taccgctgaa 3193861 tttgacacca tcagtctgac aataaatgtt ctggcggcaa gcgcctgggc tttcagcgct 3193921 tcaggtttaa aggttgccgg catttcggag gcgacgactc caatcacata ctcttcaagc 3193981 ggaatgtttt ctacggattg atttgcggtt cgatagacgg gaatagaaac aggtgatgct 3194041 ttcaatgttt ctgctccttt cgatgctggt ttcgtgctga ctgctgtctt ttctgattct 3194101 acgctggccc ccgcttcctt attatgctgg aatggtataa ccaagagtgt gggaaccaag 3194161 agaatcaatg cacatagtac ggatagtgtg attgcgaatt gtttcatatt cagctgcctc 3194221 ctgctcggga ttcgactcta gtctagtcta tgggcaggga caagctaata tgactctcgt 3194281 tttggacaga aactttattt gtcatttacg tattcttttt tgctattttg cgcataatga 3194341 tgataataca caaaaaataa aaaaccagta tgccagagtg acatactgat tttcaagtaa 3194401 gtttatgcat ttaagtcaga aacgacttct ttattctctt gctcagaagc agactcatca 3194461 tttacacgtt cgatgtctgc gcccagagcg gcaagcttct gatggaaatc aacgtaaccg 3194521 cggtctaagt gcttcaattc agtaacacgt gtgtgacctt cagccactaa ccccgcaaga 3194581 atcagcgctg cacctgcacg caaatcagtc gctgcaactt cagctccctg aagctgtaca 3194641 ggaccgttaa tgatgacaga acgtccttca atcttgatat caccattcat acggcggaat 3194701 tcttccgcat gcataaaacg gttttcaaaa acggtttctg taatcatgct tgtgccgctt 3194761 gcacgaagca gaagcgccat catttgtgac tgcatatcag tcgggaagcc cgggtgaggc 3194821 attgttttga tgtcaatcgg tttaagctct ttcgggccga tgacacgcag accttcacct 3194881 tcatccttaa ttgttacacc catctcttcc atttttgcaa ttaaagaggt gaggtgctca 3194941 ggaaccgctc cttttactaa tacgtttcct tcagtgattg cagcagcaac cataaatgtg 3195001 cccgcttcaa tacggtcagg aataatatgg tgttttacgc cgtgaagctt ttcgactcct 3195061 tcaattttga tggtgccggt gccagctccg cggatttttc cgcccatgcc gttgatatag 3195121 tttgctaaat caacgatttc gggttctttt gccacgtttt ccagcgttgt tgttccttca 3195181 gctagagcgg ctgccataat caggttctct gtagctccta cacttgggaa gtccagataa 3195241 atttttgcgc cttgcagtcg gccttttact tcagcttcaa tgaagccatt accgactttg 3195301 atttctgcgc ccattgcttc aaaacctttt aaatgctgat caatcggtct ggaaccaatt 3195361 gcgcatccgc ccggaagtgc aactcttgca tgacctgtac gcgcaagaag cggccccatg 3195421 acaagcacag acgcacgcat tttacgaaca tattcaaaag gtgcttcagt ttgcaaagcg 3195481 tatgaagcat ttacagtcac ttcattattt tcaaaatgca catctgctcc taaatgacgc 3195541 aacacttcgt taattgtata tacatcggag agcgtaggta catcacaaat tacgcttttt 3195601 tcttcacttg ctaataaaga tgcagcgata acaggtaaaa cggcattttt agcgccttca 3195661 actttgactg tgccgtttaa cttctgaccg ccgcggacga tgattttttc caaggtattc 3195721 ccctccgcgt ccctaaattc tctatattaa tattcagtcg taacgattgg tgtgccaacc 3195781 gtaacggtat gttttccgcc cattcctgca cttctaagtg caatttgcaa attcatttta 3195841 tgtttcgagg tcataatgta ctcttcccac tcatctgtaa acgcagaaat agaaacgaaa 3195901 tttggctcaa ctacatgttc tactgatctt gcttgaaatt catttaataa ctgatttgct 3195961 tttttttgca aaacaatatt catattatca tctaagtgac catttagaca agtaaaaata 3196021 actacttttt cttggaatat cccaagtgtc tcccgttcaa actgttcata tgtatcattc 3196081 cagctatccg gtgtctctag actcatttgc tcatataata aatacgaagt tggattgtgt 3196141 tttttgaggg ttgtgacaag ctgcagtcta aaagaagtac gatttttttt gtcagtatat 3196201 gtgccaattg cctttatcat tttatcttcc cgtgcaatca cccaatcata ttgacgatac 3196261 tcttgtttta aacgttgcac tttttgataa aattcttttt cggtcagtga caagttttgt 3196321 tttgcatgca atgtccactt atctattgac acatcttgac gttccatccc ctctgccatc 3196381 tgtgctaacg gcgttaattc actcgcatga atggtatgga aaacagcaat gacgaagctt 3196441 aacatgacgg aaatgataat agcgtggctt acttgttttt tcttcatgtt catctctccc 3196501 ccttatcccc agttttaccg gaggcaagag gcgccatacg taaaaatctt cgtcaaaact 3196561 cgagctattc gcttcaaccc gcttctccca accatttaat aatgttcaaa acctattaaa 3196621 atagataggg aagctgctgt gaataattga ggtaatctaa aaagaaattg gcaacggccg 3196681 ttccaatggc gattgtcagc aaaatcatca ggagtcttgc ctgcacgact ttgccttttt 3196741 tgattaacgg atctatattg acggcttgca acgcccacca agtcactgct ataaaaatca 3196801 ggtgaacgac aatgccgatt gcagcctgct gtcccaatac actcatctat tacactcctt 3196861 tctctgcgtt catacccttt cttattatat aagaagcaca gataaagatg atacatttta 3196921 tacagaacgg aataatcagc caaatctagg gctaatcccc gcttaaagtg cgattctttt 3196981 acatggtata ctttattgga aaggagctgg caaatgtgaa tcattctttt tttcagcctg 3197041 aaaagcaata tggtgaggac ctgccaattt ttgatcagga atgggaagca attgcattct 3197101 attatgatta tagacagtca cagattgaag aactgaatga attgtgtcag ttttttaaca 3197161 tttctcttac ctatacgaga gaaagccttg aagagcttga aaacctctat tttcaaagta 3197221 tacaagaact tttgcttgct gattggaatc ttcctattga agaattcgag aaaatgatca 3197281 gtgtttatct tatagattgt gtgattgccc gccatgaaga tgctgaatgg gttgtaaaac 3197341 cttatcccta taaagacggc gcttatacac ttggctttag aagacatcgc aaatcgtggc 3197401 atacaatgaa tgcctgtgat ggtttatacc tgcgtccaaa agaggatcgc ccgttgctgt 3197461 cgctgtttga ttctcttgtg cgttcataaa aaaatccttc tcataaagag aaggattttt 3197521 tcttatttcc ctgctacatc caatctgttc aaagcccgct gtaacgcaag ctcagcccga 3197581 cgaatgtcag tatcatctga ttgagaattc aaacgctcct gcgcccgctg gcgtgcagct 3197641 tcagcgcgct ctttatcgat gccttccgct gtctcggcag cctgggcaag gatggtgaca 3197701 tgatcaggac ggacttctac aaaaccgccg ctgacggcaa ccatttcagt ctgcccgtct 3197761 tttttcagac ggacagcgcc gattttaaga ggagccacgg ttggaatatg gcctggcaaa 3197821 ataccgagat cgccgctttc ggctctcaca ctcaccattt cgatatccgc atcgtatact 3197881 gggccgtcgg gagtaacgat attgacttta acggtcttca tgcttttacc ctcctaggac 3197941 cagattaaac ttctacaccc atttcttttg ctttctcaac aacttcttcg atacggccta 3198001 caagacggaa tgcatcttct ggaagatggt catatttacc ggctaagatt tctttgaagc 3198061 cttgtaccgt ctcttttaca ggcacgtaag aacctttttg tccagtgaac tgttcagcca 3198121 cgtggaagtt ctgagaaagg aagaactgga tacgacgtgc gcggtgaacg acaagtttgt 3198181 cttcctcgcc taattcatcc ataccgagaa tcgcaatgat atcctgaagc tctttgtaac 3198241 gctgaagcgt tgactgtact tcacgcgcaa ccgcatagtg ctcttctcca acaatttcag 3198301 gagcaagggc gcgtgatgta gatgccaacg gatcaaccgc agggtaaata cccatttcag 3198361 ttaatttacg ctcaaggttt gttgtcgcat ccaagtgagc gaacgttgtc gccggcgccg 3198421 ggtcagtgta gtcatcggca ggcacgtaga tcgcctggat agatgtaact gatccaacgt 3198481 tcgtagacgt gatacgctct tggagctgac ccatctcagt tgcaagcgtc ggctgataac 3198541 caaccgctga aggcatacgg ccaagaaggg ctgaaacctc tgaacccgct tgtgtgaaac 3198601 ggaaaatgtt atcgatgaag aacagtacgt cctgtccttg tacatcacgg aagtgctcag 3198661 ccattgtaag gcctgtcaaa gcaacacgca tacgtgcgcc cggcggctcg ttcatttgtc 3198721 cgaataccat ggctgttttg ttgattacgc cagagtcact catttcgtag aaaaggtcgt 3198781 tcccttcacg agtacgctct cctacgccgg cgaatacaga gataccgccg tgctcttgcg 3198841 cgatgttgtt gattaattcc tggattaata cggttttacc tacaccggca ccaccgaaca 3198901 atccgatttt accgccctta atgtaaggag caagcaaatc aacaacttta atacctgttt 3198961 caagaatttc aacttctgtt gaaagctgat cgaatgaagg cgcctgtctg tgaatcggat 3199021 cctttttcgc atccgcagga accggctcat tcaaatcaat attttctccg agaacgttaa 3199081 atacacgtcc aagtgttaca tcaccaaccg gtactgagat tggcgctcct gtatctacag 3199141 cttccatacc gcgctgaaca ccatctgtag atgccattgc gattgtacgg actgtatcat 3199201 cacctaaatg aagagcgacc tcaagcgtta aatcaatacc tacttcgttt tcacttgcag 3199261 ctggctgtga aattttaatc gcattataaa tttcaggcaa gtgaccgtct tcaaaacgca 3199321 cgtcgacgac cggtcctaat acctggctaa cgcgtccttt cttcatcgct atccctcctg 3199381 acaaaatctt tctattctaa agcggctgct ccgccgacaa tttccgtaat ttcttgtgtg 3199441 atggctgctt ggcgagcgcg gttgtaagaa agcgaaagtg aatcgataag ttccttcgcg 3199501 ttgtctgtcg cgtttttcat cgccgtcatt cttgcagcgt gctcacttgc tttactgtca 3199561 agaagcgcac cgaagattaa gctttctgca tattgaggaa gcaaaacctc cagaacctcc 3199621 tcttcagatg gttcaaattc ataagacgcc gttctttttc cgccgccgct gcccaaatca 3199681 gataacggca gaagtttttt ctccgttact tcttgagtaa tggcgctgac aaaatggtta 3199741 taaacaaggt gcaattcatc aaacgcaccg tctataaaca tttgaatcgt ttgacgggca 3199801 agatctttaa tttctgtaaa cgttacttca tctccaagtc ctgttaactc ggaaatgatc 3199861 ggaatctccc gtttcttaaa gaaatcacgg cccactcttc cgatggcaat caccgcatac 3199921 tcatccttag actgatgacg ttcttgcatg gcctgataag cactccgtaa aaccgaactg 3199981 ttaaaagcgc cggcaagacc gcggtcagac gtaatgacaa ggtatgccgt ttttttcact 3200041 tctctgctga gaagcatcgg gtgcttcacg ttgccggaaa ctcttccgac gtttgacaca 3200101 acctcttgga ttttatccat atatggcaca aatgattttg cattgttttc agcacgattc 3200161 agcttagccg cagataccat ctgcatggct tttgtaatct gacttgtttt tttcgttgac 3200221 gtgatccttg acttaatatc gcgtaatgag gccaaagatt tcaccacctt ttctcttcat 3200281 ctgcgtaaaa agagagaaaa agagaacctt tttctctcat cagcattcga gttagttgct 3200341 tggtgcaaat gtgcgtttga agccttcgat tgcagctttg aagtcttcat cagcaggaag 3200401 gtttcctgtt ttcgcaattc cgtcaagcag gtctttatgg ttttggtcaa ggtacatgta 3200461 gtactcttct tcaaaacgtc tgatatccgc cacaggaata tcatcgagat atccttttgt 3200521 cagcgcataa agaatagcta cttgcttttc aaccggaagc ggcttgttca gatcctgctt 3200581 cagcacttca actgtacgcg caccgcggtt cagttttgcc tgagtcgctt ggtcgaggtc 3200641 agaaccgaat tgagcgaatg cttccagctc acggtatgac gcaaggtcaa gacgcaaagt 3200701 acctgatact tttttcatcg ctttgatttg cgctgagccg ccgacacggg atacagacaa 3200761 tccggcattg atcgctggac gtacgcctga gaagaacaaa tcagattgca ggaagatctg 3200821 tccgtcggtg atggaaatga cgttcgtcgg aatataagca gagatatctc cggcttgtgt 3200881 ttctacgaac ggcagagctg taattgatcc tgcgcctttc gcgtcgctaa gctttgctgc 3200941 acgctcaagc agacgggaat gaagatagaa tacatcccca gggaacgctt cacggcctgg 3201001 cggacggcga agaagcaagg acagctcacg gtaagcggcc gcttgtttag aaagatcatc 3201061 gtatacaaca agaacgtgct tgccgttgta cataaattct tctgccattg taaccccagc 3201121 atacggtgcc aggtacagaa gcggtgccgg ctgtgacgca gacgccgtta caacaattgt 3201181 ataatcaagc gcgccgtgtt tacgcaatgt ttctactacg ccgcggactg ttgattcttt 3201241 ttggccgatc gcaacatata cacagatcat gtcttggtct ttttggttca ggatcgcatc 3201301 gatcgcaaca gatgttttac ctgtttgacg gtcaccgatg atcagctcac gctggccgcg 3201361 gccgattgga atcagtgcat cgatcgcttt gataccggtt tgaagcggtt catgaacgga 3201421 tttacggtcc ataacgcctg gtgcagggct ttcgatcgga cgagttttgc ttgtcagaat 3201481 cgggcctagt ccgtcaaccg gctggcctag cgggtttaca atacggccga ttaactcttc 3201541 accaacagga acctccatga tgcggcctgt tctttttact tcgtctccct cacggatctc 3201601 actgaaaggt cctaagatga cgatacctac gtttgattcc tcaaggtttt gagccatacc 3201661 caaaacaccg tttgaaaatt cgacaagttc accggccata cagttgtcaa ggccgtgcac 3201721 acgtgcaata ccgtcaccga cttggatgac tgtacctacg tcttgaactt caatatcaga 3201781 ttgataattt tgtatttgct gttttatcag cgtgctaatc tcttcagctt tgatgctcac 3201841 ttaggtttca ccccttctat cgattttccc cggctaattg acgttcaatg cgctgaagct 3201901 tcccgcttac gctgccgtca taaatccggt ttccaatgcg gactttaata ccgcctatta 3201961 aatccgtctg cacttcattt ctgattctca gtgaagcgac tccggctttt tttgcaaaca 3202021 cttgtgataa tggtaacatt tctgcatccg tcagcggttt cactgaatat acgattgcgt 3202081 cttctgtttg acgggccaca tttgcgagtt tgataaactc atctgtgagc tcagggacaa 3202141 tcgcggcacg atggcggtca atcaaaagaa aaatcgtatt gagtacggac tgtgacaaag 3202201 agccaaatgc attttgaatc agctcttttt tcttcgcagc cggcaccttc ggatggttca 3202261 acacatcatt aagcgctttt tcattttgaa atacttgttt tacaacaatt agctcttctt 3202321 ctacttgatt cagctgagcg gactcattgg ctatatcaaa aagagctgat gcatatcgtt 3202381 tagagacagc tgatccactc atcggctttc tcctacctct ttaagatagt cctggatcaa 3202441 tttctcttgc gcttgttcat ccagttcttt ttcgatcact ttcgacgcaa tcatgacaga 3202501 aagagacgct acttgctcac ggagagcaga aaccgcctgt tccttttcct tcacgatttc 3202561 agttcttgct gcttctttca gacgttcaga ttctgcacgt gcagcctgaa taatctcttc 3202621 tttttgcttc tctcccagtt tctttgcgtt ttcgataaga gtttgggatt cctgtcttgc 3202681 ttcttttaaa agaacgcgct gctcttcaat cagctgctgc gcttctttat ttttttcttc 3202741 agcagacgta atttctccag cgatgtggtc ttcacgctgt ttcattatgt ttaatagcgg 3202801 ccctaaagcg tatttcttca gaagcgctaa taagattaac atagctaaca gttggaacag 3202861 gatatctccg ccgttaaacg acaatcctag ttcaagtggt aattgagaca tctactacgg 3202921 caactccctt ctgcaggttt ttctttgctg atccagcagc cgcacttgtc tcttttcagc 3202981 cggcaaggcg ggatgcttat cagacataaa gcaatggcga aggttctctt ggaatgatct 3203041 tcgccatttt tagttcatat aaggctttta tgcttagcca aagaacgcta agaatgcgat 3203101 aacgacagcg ataataggaa gggcttcaac taatgcgata cccatgaaca taagagttct 3203161 cagttcttta cctgcttccg gctgacgggc aatcccctct accgtacgtg aaacaatcaa 3203221 accgttacca atacctgcac caagtgcgcc taaaccaatt gcaatcgcag ctgctattaa 3203281 attcatgaaa aagttcctcc tttaaaatgt tatccgtttg gatataatgt tttaatgatc 3203341 atgactgatt ttatgagaca tgtacaccat cgtcagcatt gtaaagataa atgcctggat 3203401 agcaccaata aataaactga atgcttgcca tgccagcatc ggcagaatgg caccgattgt 3203461 accgacaaga ccgagagcca cgctttgcga ataatggctt gttgctaatc ccgcaagcag 3203521 gccgagaaga atctcaccgg cgaagatgtt accatacagc cgcaaaccta gagtcagcgt 3203581 attcgcaaac tcttcgatga ttttcatcgg gagcatgaat ggaacaggtc ttaaatagtc 3203641 tttggaatat tccttgagcc ctttcatctt cacaccatag tagtgggtta aagcaacaac 3203701 catcacggct agcgttaatg taatggcagg atcggctgtc ggagacttcc accagagctc 3203761 atgtccgatt gtaatagaga acggcagccc cagcatattc gacacaaata tgtacatcag 3203821 caatgtgaca ccaagtgcca agaagttagc ccctgttttt aaatccattg tactgccaat 3203881 aatattgcgg acgaaatcaa caatccattc cataaagttc tgggcttttc cgggacggat 3203941 cgaaagcgtt cttgtcgtca atatagcaat caataaaaca atcacactcg ccacagtaat 3204001 catcagaatg tttgtcagat taaaagtaag acctagaaat tctatagttc tgtaaccatg 3204061 attcaaaggg ttttcacctc tcttccattg atgaacgttt aagctggata aaggaatcta 3204121 tcataatgac agggtatatt gtcattaatc caataactgt acttgccata tgaaagtatt 3204181 cgggattttt ataggcaaca gccacagcaa gaatcgcatt gcaccaccgc gctgcgctcc 3204241 cgagagatcg tatggacttt cctttctcta cagctctgtc aaaagcattc attcttctga 3204301 cgagcagtaa aaaattaaac aaactgaaaa cagttcccag aataaggcct aaaaaaacgg 3204361 ttttatacgc tgttaaacca taacccagta catacactgc caaaatgaac aataaatatt 3204421 tgcgttgtct gctaaatgta agcttgggat cgtccatcaa ttatctgtct cctgatgaaa 3204481 aaataatgta tagcttggat acggcaaaaa tcagcggtta acccttagta gaagaccttt 3204541 tttgaccggc aaaacgggcc tgttcgaaaa aatcattcat ccgcaagcct tgcagggatg 3204601 ctgtttcatt cgcttaaata aatcctcata atacgggttt gctgagagga tttacattga 3204661 ggatgaggac tataatgaaa gctatgaaaa ccttctcata ataccctcgt ttagcataca 3204721 atagccccta acatgtgtca atctgtttaa agttaaaaaa ctttttatac tttacgtctc 3204781 cacagaatgt tcacattttc acctataatt gtatacagat tcaccgaata gcaaaaaact 3204841 ggataaaaaa atgaaacccc cttttgggga tttcattttt tattttgttc caaacatgcg 3204901 gtcacccgca tctccgagac ctggaacaat atatcctttt tcatttaatt tttcatctag 3204961 cgccgcaatg taaatatcaa cgtccgaatg atgcttctgc aattcttcca caccctccgg 3205021 cgctgctaca agacacatga aacggatatt tttcgcaccg cgttttttaa ggctgtgaat 3205081 ggcttcaact gcggaaccgc ctgtagcgag catcgggtca accacgatga attcacgctc 3205141 ttccacatca gaaggaagct tgacatagta ttccacgggt tttaaggttt ctggatcacg 3205201 gtaaaggccg acatgtccca cttttgccgc aggaatcagc tttaaaatgc cgtcaaccat 3205261 tcccaatcct gctctgagga taggaaccac tccgagtttt ttccctgaga tgactttcga 3205321 tttcgcagcc tgaaccggtg tattgatatc cacttcttcc agaggaagat cgcgggtaat 3205381 ttcaaatgcc atgagtgtag ccacttcatc tactaactct ctaaaatcct tcgtacctgt 3205441 attttcattc cgtatatatg tcagcttgtg ctgaattaaa ggatgatcaa atacataaac 3205501 ctttcccata ctgtgtttca gctccttttt tattgtccca tcaacaatta cacacttcta 3205561 ttgattctac aaaaaaagac attgagtttc aagaacatcg tcaaaaaacc cgccgggcat 3205621 aagcccaagc gggttttagg atcttaataa tctaattctt tatataaagg aaatttatca 3205681 gtcagagcag ctacacgctg tcttgcttct tcaagttttc cttcatcttc gtggtttttc 3205741 aatgcaagcg caatgatagc accgacttct tctaatgcgt ctccgtcaaa accgcggctg 3205801 gttacagcag ctgtaccaag acggatgccg cttgttacga aaggtttttc aggatcatat 3205861 ggaatcgcgt ttttgttaga cgtaatacca atttcatcaa gtacatgctc cgcaacctta 3205921 ccagtcagtc cgagcgaacg aaggtcaaca aggataaggt ggttgtctgt tccgcctgaa 3205981 acgagctgga tgccctcttt cgttaaggct tcagccagac gtttcgcgtt tgaaatgacg 3206041 ttttgtgcat atgttttgaa atcgtcctgc aatacttcac cgaatgaaac agcttttgcg 3206101 gcaataacgt gcatcagagg gccgccttga attccaggga agatcgattt atcaattttc 3206161 ttgccaaact cttcacggca aaggatcata ccgccgcgag gaccgcgaag tgttttatgt 3206221 gttgttgttg taacgaaatc agcgtaagga accgggtttg gatgaaggcc tgccgcaaca 3206281 agtcctgcga tatgtgccat atccaccatg aagtaagcgc cgacttcatc agcaatttca 3206341 cggaatttct taaagtcgat tgtacgagga tacgcacttg ctcctgctac gataagcttc 3206401 ggtttatgag cgagggcttt ttcacgcacg tcatcgtaat caatatattg agtttcttta 3206461 tctacgccgt actcaacaaa gttatattga acaccgctga agttgactgg gcttccgtgt 3206521 gttaaatggc cgccgtggga gaggttcatc ccaagtacag tatcgccttg ctccaaaatc 3206581 gtgaagtaca ctgccatgtt tgcttgtgcg cctgaatgag gctgaacgtt tacatgctcc 3206641 gctccaaaga tttccttcgc gcggtcacgg gcgatatctt caacgacatc gacgtgctcg 3206701 catccgccgt agtagcgttt gcccggatat ccttctgcgt acttatttgt caaaacagat 3206761 ccttgtgctt ccataaccgc ttcacttaca aagttctcag aagcaatcaa ttcgatctta 3206821 gtctgttggc gttcacgctc atttttaatg gcgttaaaca cttgttcgtc ttgcgcaggt 3206881 aaatgtttca tcagcgagat cctctcctat ccgtatcctg ttctttgttt ttaccatcac 3206941 tattgtacat ggtttttaag gccgatgtaa aagattattt ttaaaaaatc taaattttta 3207001 ttggtaaaaa cgaatattaa taacttaaat ttaatttaaa gttcggaatt tatttcacta 3207061 tcttaaaata aaagaaaaga ctggctatgc agtcctttca ttcgcactca taaaccgccc 3207121 gcactccgcc gattagtttc ggccgtgtac gcgccaatgt cacatgagct gaaccgaggc 3207181 tgttttgaga gacacgcaca gggacagcca ccggtttcag atgcatgccg ataaacgtat 3207241 cgcctatatc aattccggcg tcagcctgaa tggtttcaac aagaacagga gacttcatct 3207301 gcttaaacgc ataagacgcc atcgctccgc ccgcttttgg aacgggcacg gcagaaacgg 3207361 ttggaagcct gaacagcttg gctgtttctg cttcgacgac aagcgctctg tttaaatgct 3207421 cgcagcattg aaacgccaga tggattcccg ttttttcccg gagctcagca agtccgctgt 3207481 agatgctttc agcgatatct acactgcccg atgtgccgat ccggctgccg gccacttcgc 3207541 tcgtgctgca tccaaggacg aagagctgat cttgtttcaa ttccgcttgg tcctgaaact 3207601 cagacagcat cgtcttccac gtttgtttca actcattcat taaacagcac ccctacaggt 3207661 ttttctcttc ataatcggag atttttccaa tacgcgtttg gtgtcttccc ccggtaaact 3207721 cagtagtcag ccagattttt gcgatttccc gagccaaacc aggtccgatc acccgttcac 3207781 ccatcgcaag gatgtttgtg tcattatgct ccctcgtcgc cttcgcgctg aaggtatcgt 3207841 gcgccagcgc gcagcgaatc ccttttactt tattagcgga aatgctcatg ccgatgcctg 3207901 tcccgcaaat taaaatgcct ctgtcaactt cgccgctaac cactttttcg gccaccggaa 3207961 aagcataatc cggataatcg acagagccgc tgccgcagtc acagcccata tcaatatatt 3208021 caatttgcaa ttcgtccatt aactctttga tttcatttcg aatgtgaacg ccgccatgat 3208081 ccgatgcaat ggctactttc atctgctttt cctcccagcg tgtgtgatgc ggcccgcccg 3208141 ctttattgac cgcgcagcct gtccgctctt tgattcacac catatgatgt gcttttcact 3208201 atattctact ccttcacgca ggatttgcaa atgacctgtt tgcagatttt ctgacaactt 3208261 atctacggtc ttttttcagc tgttttgcca gctgccgaag aagctcttca agctcatctc 3208321 gcgtttgttt atagatgtca attgagccgc cgaacggatc gaggacatca ccatggctgc 3208381 ctgtgacata ttcttttaac gtaaacactt tatcacgata acgtccaaat tggctggcaa 3208441 tgatctgttt gtgctgatgg gtcatagcca gaaccaaatc agccgattcc ataagttctt 3208501 cagttaatgg agaagacaca tgattaaggg caatgtgttt ttcaaacagc gcttcgactg 3208561 catgaggcgt cgctttccca ttaggtgaag caaacacgcc tgccgagcgg acattgacat 3208621 tcagcccttc cctttctgca attgatttaa aaagcgcctc agccattggg ctgcggcacg 3208681 tatttccagt acagacaaaa ataatatcca tgtcagtcac cccttatttt tctctattat 3208741 atatgaagaa aaaagaaacg gcgacttcgt ttcttttatt ggtatattaa attggcaaaa 3208801 gcagctttaa tccaaacacg attaatatga tgcccccgag cgcttcgctg tatgtgccaa 3208861 gccatgactg cacttgtttt ccgaccagca ggcccagcca tgtcaacatc atgctgaaca 3208921 gcccgaacag ggtaattgtg aggagcggat gcgagccgta tatccccaag ctcaagccga 3208981 cggaaaagct gtcaaggctg acgccgatgg caaacagcaa taagcccggc cctgccggtg 3209041 acatgaatcg ttcttctgac tgtttaaaag aggccataag catttgaacc ccaagaacaa 3209101 aaagcagcgc cccaccgata taaaccgcta acacgccgag gagccctgac agcatgttac 3209161 cggccgccat ccctgcgaga ggcatgatga cgtgaaagag gccgatgatg aaaccaatat 3209221 agaatatctg cttctttcta agtttgacca tgcccattcc aaggccgaca gaaaaagcat 3209281 ccatccctaa agcaaacgcc atgatgctta atgtaatcag ttcgcctata aacaaatccg 3209341 acatacataa ataaccccct tggacacgcc ccgctttttt agcctatgcg tgtccaaaaa 3209401 gggttagaac atctgactgc tttcagcgaa tcactcttcc tccggcggct ttcatcagcc 3209461 tgttcataat agcaagaccg acacctgtat ccggaaagga ttccgctata atgaaatcca 3209521 ccttattctc atcaaagctg cgcaaagcat catacagccc tgccgcaaca gtctcaagct 3209581 gagcccgtct tccgcagctc ttcacataat cagcggaata aacgcccgct ttttcttctg 3209641 tcgtcaggac accgacccgt cttccaccct gttgatattc ttgaatgagg tgctgaatgc 3209701 gctctgggct gccttcgcaa atggcaagag gcgctgtcgg cgcataatgt gtatatttca 3209761 tccctggaga aatcggcttc tcgttttggt cgctgagccc tttatccaca tggatcggcc 3209821 cgatcaccgc ttcaatttgt tccttcgtaa tgccgccagg acgcaagaga acagggatgt 3209881 cgtccgcaca tgaaagcaca gttgattcga ccccgattcc ggtagggcct ccatccacaa 3209941 taccggctat gcggccatcc aagtcgtgag ccacatgctc cgcttttgtg ggacttggct 3210001 tgcctgatag attggcgctc ggtgctgcaa tcggcagtcc cgattcgcga atcaatgcaa 3210061 gggcaagcgg atgatccggc attctaatgg caaccgtttc aagacctgcc gttacacgag 3210121 gtgaaagcgc atcaggtttg caaggcagaa tgagcgtaag tgctcccggc caaaaccgtt 3210181 tcatcaatgt tttcgccttt tccggcgccg ggcccgttaa atcctcaagc tggctgatat 3210241 ccgcaatgtg gacaatcagg ggattatcgc tcggccgccc tttcgcctca tatatttttt 3210301 tgacggcatc cgtatttttt gcgtttgcgc ctaggccata tactgtttct gtcggaaagg 3210361 caacgacctc attttctcgg agcaaagcgg ctgcttgtgc aatttgtgga tcatttgtgg 3210421 ataactcgtc agttacatcc acaaaccatc ttttcgtttt catttctgac caaactcctt 3210481 attcacaaca ataaaacgat tgttttacgc gtgtaatcct tttgaaagta taaaagatgt 3210541 cctgtaataa aacaagcgtt atccacaaat tgtggacaac gctaataaag aagtggataa 3210601 gtatgtgtat aaactgcact tatccagacg cttttttcat caaaacggct ccttctgttt 3210661 gccgcgattc acagaagtga tcagaagaaa acagctcctc cggtacactc tcagctcttt 3210721 caaaacccat ggccgtcaga aagtccgcag aggaatgctg atttgctact aggtacacgg 3210781 ttttgatctg atgcttttcg cacagcacct ccatgctttg aaaaagcgtg acgatgtggc 3210841 cttggtgaag cttgtccgat atgacaagtg atcgcagcag cccctggtca cagcttattt 3210901 tttcaatacc gaggcatccg gcaatgtttt tctcactgtc ctccagcata agaaattgag 3210961 tgaagccttc tttcacgcct tcatagctgg tttttgcctg ttttaaaaat gcctcgagca 3211021 catctccgtc tttttccctt gccacccgca gttgataaaa catccgttca ccccgttttt 3211081 gcgttctttc ttccaatcta tgaggcaaat ctatttttag accagatgat taggaaaaaa 3211141 ggtcggaaat ccattcgact aaaaagaatt tcacttctgt gccgtcttct ttttcttcgt 3211201 tctcttcttt tttggctttt tccgctttag cggttacgtc ctcaagcact ttttcagtct 3211261 gcttttttga ggcttcttta tcttcttgtt ctttgacggc ttccccgtta gaaaaatcaa 3211321 gaaagcagag gggcgggaac agcacacacc accagttggc gccgtctccg tttccaagcg 3211381 taatcaaaat cgcttcatac tcaccagcgg gatataccat gttgccgtaa agctttgtcg 3211441 gaaacgagat tttgtcaaaa tcaacggata tcgactgatt cgctccttct ttctccattg 3211501 tttcctttgc aattgctttg atttcaggca gctttgaacg aatcacgcga cgcgcttctt 3211561 caatagaagt aatatccttt acccaagttg tgatttcttt attcaccgcg tctcttatat 3211621 gacgttttaa ttgctggtct tgatcactat cgctgtttgc cagtattctc aaacgaatcg 3211681 cctgatcagg tatgaccacc ggctgatttt ccgatttttg tgccgtctct tcttttgcca 3211741 gccctacgag cgctccggat aataaaagaa agatatatat acaaatgatt actgtttttt 3211801 tcatcggtcc ccaccgttcc tctccgtgct ttgtttctag ccctattatg gacaaggaga 3211861 gcctgggata aacgtgcagg gtgaaaaaaa tctagcaagc tgttaatctt atttatggta 3211921 cgatagtgtt ttaggaggtt taagatgaaa tacaattata cagtgctgtt atcagcattc 3211981 acgatgtccg ttctttattc agtaatttat attcattcat ttatcattgc cgctctcatc 3212041 acaatggcat tttattttct gtttccttat ttgatcttcg cactgccgct tcaaatcatg 3212101 atgaataaaa agccgaaacg tttcagccct ttgtatctgc tgtattacct tgccgctgct 3212161 tttattgcca acgcgatcat tttcggcatg cttcagcctt cgggacaatc tctgtttcaa 3212221 aatacagcct tttatctttt cgctgtatta acagctctta tctattggat atgggattct 3212281 gttttactgc aaaaaaagga agcctaagag gcttcctttt ttattaaaac aaaatcgtca 3212341 gtaaataaca tagaatggaa ggtatcgccg caacaaagaa agcggccgcc attttcatgc 3212401 gagatgtacg gccttctttg gtttctgaat ggtagtttgc ccgctgatcg cttccgctta 3212461 cagccaaacc cgatgtaatg atcgcgagcc ccactaaaac gagagacgca acgccaaaaa 3212521 tcgcttcata tgaaagagcc tgcggaaaaa tggtgccaat catgctctca atcgcaatga 3212581 gcaggattcc tgctgtcagg gcctttttca tgtttacatc ccctttgctg gtgttaaaca 3212641 gcttgatcca ttcactcgcc agcaagctgc ttatttattt ttatgaatca gagcgcatat 3212701 ggttctgtct tttccattaa tatctttcag cacttccact tccgccccct taaacgcctt 3212761 gaggatcagg tctttgaccg ccgctccctg tttccagccg atttcaaaaa cgacaaatac 3212821 tttatccttc ataacaagcg gaatgtcttc cataaaccgc ttataaaatt tcagcccgtc 3212881 tccgccatcg gtgagtgcgt gcagcggctc atgaaaacgg acaatttccg ataaatcagc 3212941 catttcttcc tctgaaatat atggcgggtt tgagacaatg atatccgctt tttttcccgc 3213001 cttaataaaa ggctcaagca gatcgccctg ataaaagcgc acattcgctc cgagtttttc 3213061 tgcattggca gaggcgactt gcagcgcctc tttcgaaata tcgaccgccg acacagaaaa 3213121 gctttggttt tcaagcgcaa gcgtgacggc tattgcgccg ctccctgtac caacgtcaac 3213181 aacttcgagc ttgccgtctt cagaaaaaac actccgatat ttttcaagca aatgaaagac 3213241 aacttcttca gtttccggcc gcgggatcag cacatcatca ttcaccataa attcccgtcc 3213301 ataaaaaaac tcttttccta taatgtattg aaccggcacg ccctctttat gcatctcaac 3213361 gtgacgctta aagcgataca gttcgtcttc accaatcggt tcctgtaagc ttgcgagcag 3213421 cttgcttctc tccattccgg tatcataaag caataggagc tcggccgcat tttcttctct 3213481 tcccgcttcg gttaaataag aagaagccca tttcagggct tcgaatatcg tcttcatctt 3213541 aaccttccga ctgctgaagc ttgcttgcct gatcttcaac aatcagcgct tcaaccactt 3213601 cgtcaagttt tccttcaaga atctgatcaa gcttttgaat cgtcaaaccg attctgtgat 3213661 ccgtcacacg gttttgcggg aagttgtatg tgcggatacg ttcagagcgg tcaccagatc 3213721 cgactgctga tttccgtgtt tgatcatatt cagcctgggc ttcctgctga aatttatcat 3213781 agattctggc acggagaacc ttcattgctt tttctttgtt cttaatttga gatttttcat 3213841 cctggcatga tacaacaaca cctgtcggca agtgagtcag acgaaccgca gacattgttg 3213901 tgttaacgct ttgtccgccc ggtccgcttg aagcaaatgt atcgacacgg atatccttct 3213961 catggatgtc gacctctacc tcttctgcct caggaagaca tgccactgtt gcagtggatg 3214021 tatggatgcg tccgcctgat tctgtttccg gaacacgctg tacgcggtgg gcgccgtttt 3214081 catatttgag tttagaatac gcgccgcttc ctgtaatcat aaagatgatc tctttgtagc 3214141 cgcccgttcc ggttacattc gcttccatga cctctgtttt ccagccctga agctcagcat 3214201 aacgggaata cattctgtac agattgcccg cgaataaagc ggcttcctcg cctcccgcag 3214261 ccccgcggat ctccatgata acgtttttgt cgtcattagg atctttcggg atcaggagca 3214321 ccttcagccg ttctgacagt gtttccgttt ccttctgaag ttcagaaatc tcttccttca 3214381 ccatgtcgcg catctcagca tccagcttct cttcaagcat cgcttttgca tcagccagct 3214441 gttctgacgc atctctgtat tgtctatata cgtcaactgt ttcttgtata tcagattgct 3214501 cttttgaata ttctcttagc tttttcggat cgttgactac ttctggatcg ctcaaaagct 3214561 catttaattt ctcgtatcgt tcttcaattg attttaaacg gtctaacacg gtcttcacct 3214621 ctgttttcct gtgcgtaaca ttctcattat agtatagtga ttaaccccag tcaaaagcat 3214681 ttcaatccca gctggaaaag ctccctctgc tatactggaa ttcgaggagg gatgatgttg 3214741 ctgaaatcca tacatcatat tgcaatcata tgttcagatt acgaaaagtc gaaagctttc 3214801 tacgtacata agcttggttt tcaggtgatt caagaaacgt accgcgaaga gcgcggctcc 3214861 tataagcttg atttgtcgct taacggctcg tatgtcattg agctgttctc gtttcccgat 3214921 ccgcccgaac gacaaacccg gcctgaagcc gcaggcctgc gccacctcgc ctttacagtc 3214981 ggcagcttgg ataaagctgt tcaagagctt catgaaaaag gaatcgaaac agagccaatc 3215041 agaacagatc cgctgaccgg caagcgtttc accttctttt ttgatcctga ccagcttcca 3215101 ttagaactgt atgaacaata acagtttttg aagaaaaaaa ggagataccc actttctttg 3215161 ccgaatcttt tcttgttttg tctaacggga agggaaccgc attctatggt cgaataccta 3215221 gcttaaaagg aggtatggga tcatgaatac aaatatggta gcaagtgaac tcggcgtctc 3215281 cgcaaagacg gtgcagcggt gggtgaagca gctgaatctt ccggccgaac gcaatgagct 3215341 cggacactat tcgttcacgg cagaagacgt gaaggttcta aaatccgttc aaaaacaaat 3215401 ctctgaaggc acggcgattc aggatattca tctgccgaaa agcgctaaaa agcgcacagg 3215461 cttccttgtc caaaaaacaa gtagcgacac agaacgaaga atcgagcagc ttgaacaaaa 3215521 gctggacacc cttttacagc aaaggcagga cgaaagcgaa ttgatggcaa ggatgtcgga 3215581 actggaacgc cagctgaaac aaaaagccga tgaaggtgta tcttaccagc tgcttcagca 3215641 ccgcagagaa atcgatgata ttcttgcaga tctgcaatca ctgacctcac aaatgaaaga 3215701 attcaccgct cattcgatcc ccgagactgc tgctgcttct gaaaaaacca aaacaagaaa 3215761 aaaaccgctg ctgtcactgt tcaaatttca aacctaaagc aaaaagctcc cttaaaggga 3215821 gctttttttg ttacgcagta agcgcgataa tgattggaag tgaaatcaat gacagaatcg 3215881 cactgaccac aaacgcagtt gcagtttctt cttcttgttt ctcgaaacga gtcgcaatca 3215941 tggctgcaac ggcagaacca gggaatgcaa caagaaggat tgcttttgtt gtttggtcag 3216001 ctggaagtcc gatagcaaga gcaatcagga acattaacgc aggctgaacc gcaactttta 3216061 gtaacgcaat accgatagcc ggcatactga gtttaatttt acgaatacca acggtaacac 3216121 caacagcgaa gagagcaaca ccagatgttg tgcttccaag ctgatcaagc attttaacac 3216181 ccagctcagg aagagtgaaa ttgaaaacca gcaccaagat catactgatt aacggagcag 3216241 ctgcaagcgg ctcacaaaga ccatgcagga ttgattttcc tgtcatcttc cagaagctgt 3216301 cgccactctc ttcgtttttc ttagaagact caccaacagt agcgataatg atcgcgagcg 3216361 gatcaagaat cgcgttaacc acgatacctg tgaccgcgat cggaatcgca acttcattcg 3216421 ctccgaataa gcttcccaat accgggatac ccataaatgc gaatgtcggc tgtgcagagt 3216481 tcaaagaaaa tacagatgag ttcgttaaat catacttgaa tataaatctg caaaccaaaa 3216541 gaatgatgat atagaaacca acaatcccaa taattaaaga aatcattaaa ggtacttgtg 3216601 ataaaaattc acttctggaa gttgtcaaaa taccagcgat aaagtgagct ggaagtgcgt 3216661 atttcgttac taacgtactt accccttttg ccgacttggc atcataactt ccaaaatgtc 3216721 ctgcaaacca acccagcacg ataacaaaga agatcggcgc caggaggatt aagatatcta 3216781 agatgctcaa aatattctcc tccaaatcct atgtccgtat actttagctt tacaaaaagc 3216841 tttccctcgg acagaaaaat ttactcgcta attatttcgc gatgactttt ttgtattcag 3216901 gtgtccacat tgcatcaagt accgcttgtt tcacatcttc aggctgacga tttgccacgc 3216961 cgtctttaat tgctgcttca gcaacggcaa tcgcaacttg gatagaaacc tcttgaagct 3217021 tatcaatgct tggaagcaat cctgctccag gtgtttcaag atcaaccatt tcagcaatcg 3217081 catcagcagt tgcagcaaac atagcaggtg taatgatacg cgcttcagct acaattgaac 3217141 caagtccaag accagggaac gcgaatgcgt tgttagattg tccgatttca taagaaacac 3217201 cgttgtattc tacattgtca aatgggcttc ctgttgcaat aagcactttt ccgtcagtcc 3217261 atttgaacag atcttcagga acagcttcag caaggtgagt cgggttagac atcggcatga 3217321 taaccggacg gtctacgtga gatgccattt cttttacaat ttcctctgtg aatgcacctg 3217381 aaacccctga agtaccaatc aagattgttg gtttcgcttg acgaacaact tcatcgaatg 3217441 gaatttgacc tttttcatcg cgcttccagt ctttcacttc atccgcattg cgaaggtaag 3217501 gtttttggaa atcaaggatg ccttcgatgt cttcagtcag caagcctctg taatcaagtg 3217561 tgtagaaacg tttgttagct tcttcttcag ataatccggc tagcaccatt gtgtcacgga 3217621 tttggtcagc aataccgata ccagcagaac cagcaccgaa gataacaaca cgctgatctt 3217681 taatagaagc gccggttttc ttcatagcgg caagcacacc tgcaagtgta atcgcgccag 3217741 taccttgaat atcatcatta aatgtcagga tttcatgatt gtattttttc atgatgttgc 3217801 gtgcattttt gttgccaagg tcttcccagt gaagaagcgc tttagggaag aatttcaatg 3217861 cagcttttac ataagcgtca atgaaagctt cgtagcgttc accttgaaca cgttcatgct 3217921 tgttaccaat atataaagga tcgtttagaa gtttttcgtt gttcgtaccg acatcaagca 3217981 caaccgggat aacacggcta gggtcaatac cagctgcagc agtgtagaca gccaatttac 3218041 cgattgcaat attaataccg cctacacccc agtcaccgat accgagaatg ctttcggagt 3218101 cagtagcaac gataagatca atatcgcctg ctgtcgcatg aaggttttca aacgcttttt 3218161 caataccgtc aatgttatcg attgacaagt agattccttg aggtcttcta tattcatggc 3218221 tgtattcctg aatcgcttca ccaactgttg gcgtgtacac aacaggaagc atttcgcgaa 3218281 gatggttttt cagcaattta tagaaaagaa cttcgttacg gtttgcaaga tcacttaagt 3218341 aaacattttg acgaaggcgg tcaggctgcg cttggaattg ctcgtacgcg cgttgtgctt 3218401 gttgatcaag agaaagtaca gttggcggca gaagcccttc taagccgagt tcttgtcttt 3218461 cttctagtga aaaagcaacg cctttattta aagtaggaat agataaaact tcttttcctc 3218521 taagagttgt ttctaagtgg ccttctttcg ttttttttat gttattcaag caaatctcct 3218581 tctttcttga aatagttaac caagttaagt aataacccat ctaaaatatg accgatcatg 3218641 atctttatgc gactttgtga caattattcg aacaatgtct caaaactatt tacattacgt 3218701 aagctattgt atgcctgtca aaatcaaaat tcaagagaag aaaattactt aattttttaa 3218761 tatacttatt taaatttttt aattgaatat tatcagaata taaaaaaaac accggtgttt 3218821 ttagccggtg cattctatct ttatacccat gttttggact attttttaga tttacctggg 3218881 acttcgtgat gatgtctgca tcttgcttca tatgattcag ctgcaccaac caaaatgacc 3218941 ggatcatcgt aagaagcagg tttgccgtca atgaggcgct gtgttctgct cgccggtgat 3219001 ccgcaaacag aacagacggc ttgcagcttt gtcacacttt ccgcaatcgc catgatattc 3219061 gggacgacac cgaacggctc tcccctaaaa tccatatcaa ggcctgctgc tatcacacgg 3219121 tagcctttat cggcaagaga tgataaaacc tcaacaattt cctgatcaaa aaactgcact 3219181 tcatcaaccg caaccacatc tgtactttca ctgatgtgat cccaaatgtc cgcagcagac 3219241 gaaatggcat agctcgtcat cgatgttcca ttatgggaga caacagcagc ttcgctgtat 3219301 cggttatcaa ttacaggctt aaataccctg acttcctgct tggcataagt tgctctcttc 3219361 actcttctga tcagctcttc agatttcccc gagaacatgc tgccgcaaat cagctcaagc 3219421 cacccgcttt gtttcattat gtacataggc ttcgctcccc tctctctgcc agctgtgttt 3219481 tagacaatat aaaaaacagg caagactgct gcttgcctgt tgagaaatct attattactt 3219541 aagaccgtat tttttgttaa agcgatcaac acgaccatca gcagaagcga atttttgacg 3219601 gccagtgtag aatgggtggc attcagagca aatctcaacg cgtacctctt cttttactga 3219661 gcctgtttca aattcatttc cgcaagcgca tttaactgtt gcttttttga aattaggatg 3219721 aattcctgct ttcattgtat ccatctcctt ccgccctgaa tcccgtgtgg aaacagagtt 3219781 attatttcgg agcattgtcc gaaacgcata tgagaaaatt atatcagtga tttacttctt 3219841 ttgcaaatac aatttacctt cttgcagatg atagatttgc ctgtttccat tcttgattga 3219901 gaatatcgaa aaattcctgg tttgttttgg tttttttcat ttttctcatg aacttttctg 3219961 cgaaatcagg tgaatcagac atcgttttgc ggatagacca taaacgatca agatgctctt 3220021 taggcacaag cagctcttct ttgcgcgttc ctgaacggcg gatatcgatg gcagggaaga 3220081 tgcggcgctc ggcaagagag cggtcaagat ggagctccat gttgcctgtt cccttgaatt 3220141 cttcataaat gacatcatcc atacgtgaac ctgtatcgac cagagccgta gcaaggatgg 3220201 ttaagctgcc gccctcttcg atatttctcg cagccccaaa gaagcgtttc ggacggtgga 3220261 acgccgctgg gtcaatcccc ccggaaagcg ttcttccact tggcggaatc actaagttgt 3220321 aggcgcgggc aagacgtgtg atgctgtcca tcaggataat gacgtctttt ttgtgttcca 3220381 cgagacgcat cgcacgttca agcacaagct cggccacttt gatatggttt tccggcactt 3220441 catcaaacgt tgagctgacg acatccccag ctacagagcg ctcgatatcg gttacttcct 3220501 caggtctttc gtcaattaaa agcacgatca gctctgcttc aggctggttc gctgtaatgc 3220561 tgttggcaat ttccttcagc aacatcgttt ttccggcttt cggcggcgca acaatcaatc 3220621 cgcgctgccc aaatccaacc ggcgccatca tgtccataat tcttgtagac aagaagttcg 3220681 gctttgtttc aagcaccatt tgacgatccg gataaagtgg cgtaagagcc gggaaatgca 3220741 cacgctcttt tgcagattcg ggatcatccc catttactgc ttcaacgtgc aaaagtccat 3220801 agtaacgctc attttctttt ggcgggcgaa ccttgccaga tactttgtct ccgttccgca 3220861 aatcgaaacg gcggatttgt gaagctgaga tgtaaatgtc ttctgagctt ggagagtagt 3220921 tgatcggtct caggaatccg aaaccttcag actggatgat ctcgagaacg ccttccataa 3220981 acagcagatc ttcctgttct gcattcgctt tcagaatggc gaaaatgagt tctttttttg 3221041 tcagtttgct gtaataggag attttataat gtcttgcaag ttcataaagc tctttcaatt 3221101 tcatattttc caaagaggaa atagatacgt ctttcataaa aacaccacgc ttttcatagt 3221161 caatatctta ctctgaacat gtcatctgct gcttttgcac aacatccgcc aaagcacatt 3221221 ctttttttaa cataaaggaa cttctatcgg taacacttcc acccatgatc ggcgcttttg 3221281 ttaaaaggat tgtcttaatg agttttgaag gaagcgagga caaaaacatg agaagatcaa 3221341 tacttatatc gtctgtatgc ggtagaaatt gaaactttcc tagtgcttaa aagaaggtat 3221401 tacgcagtaa aattcgcagc actctttatt tttaccttat ttcaaaaaat tattcaactg 3221461 aaataaggtt ttgacacgga attgatagag ttgacgcttt tctgcaaaag ttaaagcggg 3221521 ctcacacccg ctttttctgt ttgttatgga cggattacaa gatttggttt ctttttcaag 3221581 ctgtgtctgc cgtcaacgaa acgaacagtg cccgattttg cacggataac taagctttca 3221641 gttgtaccga cagagccttt gaattgaact ccttttaaca gctcgccgtc agtaacccct 3221701 gtagctgcaa aaatcgcgtc atcacccttc acaaggtctt ccatgcgaag cactttgctt 3221761 aaatcaaggc ccattttgtg acagcgagtg atttcttctt cgctttgcgg aagaagttta 3221821 ccaatgattt ctccgccgag tgcttttagc gcaacagcgg aaagcacacc ctcaggagcg 3221881 ccgcctgatc cgaacaggat atcaacgccc gtgtggtcga aagccgtgtt gatggcgcct 3221941 gcgacatcgc cgtcattgat caatttgatt ctggcgccgg cctcacgaag ctcggaaatg 3222001 atttttgcgt gtctttcacg gtttaaaatt gtggcaacga cgtcctcaac gtccttgttt 3222061 ttcgcttttg ccaccgcttt aaggttgtca atgacaggtg cttcgatgtc aatgcagccc 3222121 accgcttccg gaccgactgc gattttttgc atatacatgt caggagcatt cagaagcgtg 3222181 ccatggtctg cgaccgcgat aaccgtcagc gcgttccagc cgccgcttgc taagatgttt 3222241 gtgccttcaa gagggtcaac tgcgacatca acgcgagggc cgtacccgtt tccgagtttt 3222301 tccccgatat acagcattgg cgcttcgtcc atttcccctt caccgattac aacggtccct 3222361 ttcatcggca ctgtatcaaa aacgtctctc attgcacttg ttgccgcttc atcagcctca 3222421 tctttttttc cccggcccat ccatcttgct gatgccaatg ccgcagcttc tgtcacacgt 3222481 accaattcca ttgataaact tctttccatt tcaacacgat ctcctctcac aagaaaccat 3222541 tatgaatttt gaagctgttc tatttcttcg tcagtcattc tttcacgcca aattgtcgct 3222601 ccaagcccct caagcttctt ctcaaggctg ctgtatcctc ggtcaatatg ctccagtccc 3222661 gtaatttccg tgacgccatc agccatcagt ccggctacca ccaagcaggc tccggcacgc 3222721 agatcactcg ccttcacttt tgcgccttga agctcgacag gacctgtgat gatggcagat 3222781 ctgccttcta ctttcatatt ggcacccatt cgtctcagct catcaatgtg cttgaatctt 3222841 gccgagtaga tggtgtctgt gacgacactc gtccctttcg cccttgtcag gagcgccgtc 3222901 atcggctgct gtaaatcagt cggaaacccc gggtatacga gggttttgac gtcaaccggc 3222961 tttaagttct tctgcccgcc gacaatgagg agctggtcgt cgcttgtttc gatatgatag 3223021 cccatttctc tcagctttgc cgttaacgac tcaagatgag tagggatgac gttatcgata 3223081 atgacttcct tgcccattgc agcccctgca atcataaatg tcccggcttc aattctgtcc 3223141 ggaatgatcg tatgcttgca gccgtgcagt tccttcacgc cgtcgattcg aatcacattg 3223201 gtgcccgcac ctttgatttt ggcgcccatg ctggtaagca atgtcgcgac gtcaatgatc 3223261 tcaggctcct tggcagcgtt ttcgatgatc gttttccctt ctgccaaaac agcggcgagc 3223321 ataatgttaa tcgttgcccc aacgcttacg acatctaaat aaatccgtgc gcctctcagc 3223381 ctttcagctc gcaaataaat ggcgccttgt tcattggtta cttcagctcc gagtgcttca 3223441 aagcctttga tatgctgatc aatcggacgg ggccctaagt gacagccgcc aggcaatcca 3223501 atgaccgcct gcttgaagcg gccgagcatc gcccccatta aataatatga cgcgcgaagc 3223561 ttttttactt tcccgttagg aagcggcatg ctgatcatcg acgtagggtc aacaaccatt 3223621 tccccattct caaaatgcac gttgccgccg atttccttta acaggtcacg cagcgtttca 3223681 atatctgaaa tctctggaag cccttcaatt gtcacctcgg aatttgccaa aatggttgca 3223741 ggtattaacg caacagcgct gtttttagcg ccgctgatat gtactgtacc gtttaacgag 3223801 tcaccgccgg caatattcaa cttttccatg atagtctcct tccataagaa gatagctgcg 3223861 gagctaaata aaatgtcatt ttattctgtc tctgcaaata aagctcatgt ccaaaatcta 3223921 gccaattcga agagaaagaa tacaacacat tgtaaaatat caggaagaaa atagcgaagc 3223981 tttggggggt acaggtttca aaagatgcac agagacccgc cggctcgaga gacatcgtcg 3224041 tcatccggca aaagcagtac gcataccctt cattccgata tcagcttctg cagcccaatg 3224101 attccttctc tgtaaagcgg cgtcagcatc tgaagatccg ctgtatcagg tcggtgaaat 3224161 acaaaggccg cggcaaacag gcataaagct gtttgccgcc cctttcatta tttgttccag 3224221 tctgccagga attgttcgat tcctttgtct gttaacgggt gtttagtgag cgcatgaatg 3224281 actttcagcg gcattgtgcc gatatgagcc cctctaagag cagcttctgt cacgtgctgc 3224341 ggatggcgga ttgacgctgc aatgatttgc gtgtcaaggc cgtgaatgtc aaaaatctgt 3224401 ttaacttctg aaatcaggtc aagcccgttg tggccgatgt catctaaacg tcccaggaat 3224461 ggagatacat atgttgcccc cgctctggca gcaagaagcg cctggttggc attgaagatc 3224521 aatgtaacgt ttgttttgat gcctaagtca gtaagtgctc ttaccgcttt taaaccgtca 3224581 gacgtcattg ggattttcac cgtaatgttc ggagcgatct tcgccagttc ttttccttcc 3224641 tcgatcattt cctcagcttt caaagaaata acctctgcgc ttacagaccc tttcacgacg 3224701 tctgtgatct cgcgaagacg gtcgtggaat gatacgttag cttcctttgc tactaaacta 3224761 ggattcgtcg ttacaccggc gagaattcct aattcattcg cttctctaat ttcatcgata 3224821 ttggctgtat caacaaagaa taacattttc aaaaagcctc cctgattaag aaattttctg 3224881 aactgcgaat atgattgcgc tttctaaaga tagacggaaa accgcctgtc aagctgtcag 3224941 gcggctataa aaagttccaa ttgaattaag cttggtttga agaaccaaat tcacgcattt 3225001 taccgataac tgtttctttg atcgcttcac gagctggtcc aaggtattta cgtggatcgt 3225061 actcgtcagg cttagctgcc aatgtttcgc gaacagcttt tgcagaagaa atttggtttt 3225121 cagtattcac gttgatttta gctgtaccaa gtgaaattga ttttttgatg tcagcagtcg 3225181 gaattccagt accgccgtga agaactagcg gaaggccagt tgattttccg atctcttcca 3225241 tttctttgaa gccaaggttt ggctcacctt tgtaagggcc gtgaacagaa cctaatgcag 3225301 gtgcaaggca gtcgatgcca gtgcgctcaa caagctcttg gcactcttta ggatcagcgt 3225361 agattacgcc ttcagcgata acgtcatctt cttgtccgcc tactgttcca agctcagctt 3225421 ctacagatac tccgtggaaa tgagcaagct caacaacttt agcagttgtt gctacgtttt 3225481 cttcaaatgg atggtgagaa gcgtcgatca ttacagatgt gaaacctgca tgaatcgctt 3225541 tcgcacaaga ttcaaagctt gaaccgtggt ctaagtgaat cgcaacagga actgtcactt 3225601 tgtactcttc cataagtgct tttaccatag caacgactgt tttgaagccg cccatgtagc 3225661 gtcccgcacc ttcggaaaca ccaaggatca ctggagattt ttcttcttca gctgcttgta 3225721 aaatcgcttg agtaaactca aggttgttta agttaaattg tcctacagcg tacccttttt 3225781 ctttagctgt attcaacatt tccgtcatag aaactaaagg catgtcgaat gtcctcctta 3225841 tgtagcctga ttgtcttcta gcgaaaaaag ctttccaccc tagcatgacc catatattgc 3225901 tgtcatatgt aaatactcag atcgcttttt ctccataact aggataccaa cttttcgaca 3225961 aatcggcaac ataatgacat gattcatttg tttcttcttt ttgtcagtta gacttcaggg 3226021 gcagatattt tttgacggcg tctctgattt cgtcgatgtc aaacggcttg gcaaagtgcg 3226081 tcagagcgcc caattccttc gattcctgga tcatgtcgag ctctccgtat gccgtcatga 3226141 taatgacccg gatgttttcg tcaatgacct tcatccgttt taagatttcg attccgtcca 3226201 tgccgggaat tttcatgtcc aacagcacaa ggtcgggccg ttcttttgtc acaatgtcaa 3226261 gcgcctgcag gccgttcgca gcctgaaacg tctggtagcc ttctttattg aacacttcat 3226321 ttagcaaaat acgaatgccg tattgatcat caacgattaa aattttttca ttcatcattt 3226381 tacaccccaa tattatgatt ttcgtcaaaa gtaagcagta ttgtatgtat tctgtttgat 3226441 tttcctattt cctttaatta taatagtcta ctttacgaca ttttctgagc attttctctt 3226501 ttgttgtata ctgatattgt acgttataaa ggaggattca cttatgttga aaatattcac 3226561 gacgcagtta acaggtattt tttcccgcat tcaggataag gaatctgacg cgattgaaga 3226621 tggggcgcgg ctgcttgctc aagcggtgat cagcgggcat tccatttatt tatacggagc 3226681 gaatgagctt cagggcgtct tttatgaggc caccgaaagc aaagaaccct tcccatctgt 3226741 caaagccttt ccagaaaacg ctgaggaagt gacagaaagc gacagggtgc tgatgttttg 3226801 ctcagggacg ggcacagccg aagaacagga gctcgcaaaa gagctttatg aaaaaggtgc 3226861 gggagtcgta tgcgtatcgc ccgcagccaa agacagtgcg ggaatagaac agtattgtga 3226921 tgtgcatatt gattctaaat taaaaatgcc gcttgttccc gatgaagacg gcacccgtta 3226981 cgggtttccc tctttaatga cagcactgta tgtctatcac gctttatcgt ttacactaaa 3227041 agaaattctg caagagtatg cataatatct tattgtacat gctggaactt gccggaaaca 3227101 aataaaaaag acttgcccgc ttttgacaaa cggcaagtct tttttattac ttctgatttg 3227161 cagcttcgac agacgctccg ataaagcctt tgaatagagg ctgaggtctt gtcggtcttg 3227221 acttgaactc tgggtggaac tgagaagcca cgaaccaagg gtggtctttc agctcgatga 3227281 tttcaacaag gcgtccatca gggcttgtgc ctgagaatac gaagccttgc tcttccattt 3227341 gctgtctgaa ttcattgtta aactcatagc ggtggcggtg gcgctcgtac accacttcat 3227401 cctgatacac ttcaaaggct ttcgtgcctt cttcaagctt acaagggtaa aggccgagac 3227461 gaagcgttcc cccaagatcc tcaacatcct tttgttcagg aagaagatca atgatcgggt 3227521 attgagttga cggatcaatt tccgctgagt gagcgccttt taagcccaat acgtttcgtg 3227581 cgtattcaat agacgccacc tgcatgccca agcaaatgcc caagaacgga atgttgtttt 3227641 cgcgcgcgta ttttgtcgcg acgattttcc cttcaacacc gcggtctccg aatccgcccg 3227701 gcacaatgat gccgtctgtt ccgcttgtga gttctgcgat attgttttct gtcacttctt 3227761 ccgcgttgat ccacttcact tttacatctg tgtcaaacgc atagcccgca tggcggagag 3227821 actcgacaac agaaatgtat gcgtcaggaa gctcaacgta tttgccgaca aggccgattg 3227881 taatcgtttg agacaggttg ctgactttgt taacaagctc tttccactcg gacatttccg 3227941 cttctttgca tgccaatttc atgtgctcgc aaacaagctt atcaagccct tgtttttgaa 3228001 gctccagcgg aatggagtaa aggttgtccg catcttcaca ttcaataacc gcttttgtat 3228061 cgatgtcgca gaaaagcgcg attttatctt tcatatcttg agaaatcggc atttctgtac 3228121 gaacgacgat gatgtttggc tgaatgccca agctgcgcaa ttcttttacg ctgtgctgtg 3228181 tcggttttgt ttttaattcg ccagcagctt taatgtaagg cacgagcgta cagtggatgt 3228241 acattacgtt ttcacggccg atgtcgctct tcatttggcg gatcgcttca aggaatggca 3228301 gtgattcgat gtctccgaca gtaccgccga tttctgtaat gacaacatct gcgtttgtct 3228361 ctttccctgc gcggtaaaca cggtctttca attcgtttgt gatgtgcgga atgacctgta 3228421 cggttcctcc aaggtaatct ccgcggcgtt cttttttaag aactgttgaa tagattttac 3228481 ctgttgtcac gttgctgaat ttattcaggt taatgtcgat aaaacgctca tagtgaccaa 3228541 ggtccaagtc tgtttcagcg ccgtcatccg ttacgaatac ttcaccgtgc tggtacgggc 3228601 tcattgttcc cgggtcaacg ttgatgtatg gatcgaattt ttgaatcgtc acgttcagtc 3228661 cgcggttttt cagcaaacgc cctaatgaag ctgctacaat accctttcca agtgaggata 3228721 caactccccc ggttacaaaa atatatttcg tcatttcgtt tgctcctctc ttcgctctta 3228781 gctacatttt taaaatgtac tattttataa aaaatcattt agccttttaa atgatttata 3228841 agaaaaatga ggggtgaaaa taagaaagct ccctttcaat ttcttgaaag ggagcataac 3228901 gtactatgtt ctctcttcgt ttttgaagag cccaaaatac atactacata gttcgactat 3228961 gaaagtcaag atcgttttga agatgaaatc tgatactatt taatttcctc ttcttcatca 3229021 tcatagtctt catcatcttc atcaataata tcttcttcga tctcaagatc atcgtcgtct 3229081 tcatcaagat cttcttcgtc aaaatcgtcg gcttcaagat cgagttcttc ctcaacttca 3229141 tccaaatcaa ggtcgtcttc gtcgatctct tcaaactcgt caagatcaag atcttcttcg 3229201 actgctttct tcgctttttt ctttttcgcc ttgactgtcg gctgagtttc ttcatcaagc 3229261 tgatcataag gataccagct gcgaagcccc cacgtctggt cagaaagcgc caggaagcgg 3229321 ccgtcaatgt ttaaatctgt ataaaattga gcaatgcggt ctccaagctc ttcttttttc 3229381 acgccgagca aagatgcgat ttcatttaaa agctcctgaa aaggaactgg ttttttatgt 3229441 tcttcaaata attcgtgagc gatttcaact aaagccattt cctttagctc ttcctgtgaa 3229501 tattgtttga tacccaaggt cggacactcc ctttctatta cttatatgta tctgttttat 3229561 caataatgaa agcgattttg tatcgttctt atacaaacca tacctctcat tataaacaaa 3229621 ataaaacaga atatgctacc cttaacagcg ttaatttaaa taattttaca agagtgatcc 3229681 gactgagaga tgttttccgt taatccgcga gcattctgga gatgaccagt ctttgaattt 3229741 cttgagtgcc ttcatagatt tgcgtgattt ttgcatcacg catatagcgt tctaccggat 3229801 aatcttttgt atagccgtag ccgccgaaaa tctgcacggc ttcggtcgtt accttcatcg 3229861 ccgtatcccc agccatcagt ttggacatgg cggaagcttt tccatatgga aggcccgatg 3229921 attctaacca tgcagcctga taggtcagta gccttgaagc ttctatcatt gtcgccatat 3229981 ccgcgagttt aaaagcgatg ccctgctgct cggcgatcga ttttccgaat tgctttcgct 3230041 cttttgcata ttgaagcgcc gcatcaagcg ctccttgggc gatgcctaca gcttgtgcag 3230101 ctatgccgtt tctgcctccg tcaagcgtct tcatcgcgat tttgaagcct tctccttctt 3230161 ctccgagacg ctttgatgcg ggcactacac aatcttcgaa catgatttcc gttgtcggtg 3230221 aagaacggat gcccagcttc ttttctttct tgcctgtaaa aaatccttca aaatcctttt 3230281 ctactataaa agcggtaacg ccttttttct ttttctcggg atcggtgacg gcaaaaacaa 3230341 tgtaaatatc agcaacgccg ccgtttgtga taaacacttt ggaaccattt aacacatagt 3230401 catcgccgat tcgttcagca gttgttttca tgctgccggc gtcagagcca gaccctgctt 3230461 cggtcaaagc gaatgcgccg attttctctc cgagagccag ctgtgttaag tactctgtct 3230521 tctgttcctc tgtcccaaag gcaaacagcg gccagctgca aagagagata tgggcggaaa 3230581 gcgtcacacc ggtggaggcg cacacttttg acagctcttc caccgcgatg acgtaggcta 3230641 aatagtcact tccaattccg ccgtaatctt caggccatgg aattcccgtc aggcccagat 3230701 ttgccatttc ccgaaacagc tcgcgatcga agcgttcttg ttcgtcccgt tcagccgctg 3230761 tcggggccac ctcatgcttc gcaaaatcgc gcaccaattt tcgtatcatc tcatgttctt 3230821 ctgataatga aaaattcatt gcttctcccc cattttcaga tcagcgccta aaacggattg 3230881 agccagaagc tcgacgacgt cgtacgtttt gacttggtct tcggcttcct tcgcctttgt 3230941 gccgtcccca agcatcgtga gacaatacgg acagccagaa ctgatcaccg atgggttgac 3231001 tgcgagcgct tgctctgtcc tggcgacgtt aatcctgttg cctgtttctt cctccatcca 3231061 cattaatccc ccgccggctc cgcagcacat gccggtttcc cggcttctct ccatttcaac 3231121 aagctgcacg cccggaatgg ctttcaaaat ctctctcggc ggatcataga cttcattgta 3231181 ccggcccaaa tagcacgaat catggaaggt aatcgtctca tgaagcgggt gctgcggtct 3231241 taattttccg tttttcacaa gctcggccag cacttctgta tgatgataaa cctcgccttc 3231301 aaatccgaaa tccggatatt cgtttttaaa taaattgtat gcatggggat cgatcgtaac 3231361 gatttttttg acatcatttt tttcaaattc agaaatattc ttctcagcca gctcttggaa 3231421 caaaaattca tttccgaggc ggcgcggcgt gtctcctgaa tttttttctt tattgccgag 3231481 aatcgcgaag gacacgcccg cgtgattgag cagcttggca aaggaaattg cgattttctg 3231541 gcttctgttg tcgtaagacc ccatggagcc tacccagaaa aggtactcaa attcttttcc 3231601 ttcttttttc atttctttta cagtcggaat ctcagcatcc ggcgcctcgt cacgccaatt 3231661 ttcacgttcc ttgcggttga gtccccacgg attcccttgc cgctcaatac ttgtcattgc 3231721 gcgctgggcg tcactgtcca tttttccttc tgtcagtacg aggtagcggc ggaggtcgat 3231781 gattttatcc acgtgctcat tcatgaccgg gcattgatcc tcacagttcc ggcaagtggt 3231841 gcatgcccaa atttcttcct ctgtgatgac gtcgccgatc aagcttggat tgtaatcaag 3231901 cgccgctgcg gcttcctgcg atccgctgcc cgctgacgcc gcagccagct gattgcctct 3231961 cgtatgccga aacgctgctg cgggcaccca tggggagcgc gaggtgacgg cagcgccttt 3232021 ttccgtgaga tggtctctga gacgcaaaat caagtccatc ggagaaagca tttttccggt 3232081 gcctgttgca ggacacatat tggtacagcg gccgcactcg acacacgcgt atagatcaag 3232141 cagctgagac tgtctgaaat cctcaatttt tcccgctccg tagctttctt tcgtttcgtc 3232201 ggtaaaatca attttttcaa gttttccggc agattccatt cgattgaaaa agacgtttgc 3232261 cgggccggcg attaaatggg catgctttga ctgaggcacg tacactaaaa agctaagcaa 3232321 gaataggaga tggatccacc atgcgatata gaaaatcacc gccgcgcctg ttttcccgac 3232381 accgctaagc ataaacgcaa tacctgaggc aattggctcg ctccaagaaa gcccatgctc 3232441 atgccaaatc agattcatcc cgttcccaag cagaacggtc agcattaatc ctccgataaa 3232501 aatgagaacg agtccggctt tgaaaccgcg tttcagcctc acgagctttt cgatataacg 3232561 tctgtagaat gcccacccaa cagcaattaa aatgagaaac gtaacaattt cctgaaaaaa 3232621 ggtgaaggcg ggatagaccg ggccaagcga cagattccgg ccgggagcca gtcctttgat 3232681 gataaagtca attgctccga actgaaccaa tataaatccg tagaaaaaca tgacgtgaat 3232741 gattccgctt ttcttgtcct tgagcagttt tttctgtccg aatacattca cccatatggc 3232801 gtgaagccgt tccttgaacc gttgatcaaa ttgttctttc tggccgagct tgatgtaggc 3232861 cagtctcgtt ttgaccaagt aaacaaacaa atagacagcg taagcggtta caatcagaaa 3232921 taataatgca tttgcgatga gaaagccgct cattccaatt cccccttttt actgataaag 3232981 accgcgatcc cctacccccg aatctgtata agattatctt tatgataaat aatgaatgag 3233041 tgttcagtca ataattaaat tcctgctgtt cgggcacact acctttacta cggaaaggag 3233101 tgccggtatg aaggtattta tcgtgattat gatcattgtc gttattttct ttgccttgat 3233161 tctgcttgat atcttcatgg gccgtgccgg atacagaaaa aaggcgtacg agcctgtttt 3233221 ttcaaaaaag aagagtgaca tcgaattgat ccactgcggc gctgatctcg ttgagcggat 3233281 gatgaatgat attcgccagg ccgcctcttc tgttcacatg atgtttttta ttatgaaaaa 3233341 tgatgaggtc agccacaata tgtatacctt gctgaaaaca aaagcccaag ctggcgtatc 3233401 cgtttatttg cttctggatt gggcgggctg ccgggcaatt aaaaaaacgg cgcttcagac 3233461 gatgaaaaat gccggcgtcc atgtccatgt gatgaatcgt ccccgttttc cttttttctt 3233521 ttttcacatg caaaaacgga atcaccggaa gattacggtg atagacggaa aaatcggtta 3233581 tatcggcggg tttaatatcg ccgaagaata tcttggaaag aaggcgaagt tcggcaattg 3233641 ggaggattat catctgcgca tgatcggaga aggcgtacat gatcttcaaa cgctttttgc 3233701 ttctgatcta aaacgaaata ccggaatcga actgggttcg gatgtttggc caaagcttca 3233761 gcaagggact atttctcaca agatctatgc gaccgacggt tattcccttg aaaacatata 3233821 cttggccaac attgcccaag cgaagaatcg ccttacggtt tgcacgcctt attacattcc 3233881 atcaaaaccg cttcaagagg cccttattaa cgcaagaaaa aacggcgtat ccgtgagaat 3233941 cattgtaccg atgaaatcag accatccgct ggtacgagaa gcggctttta cgtattattc 3234001 ggagctcttg gatgccggct gtcttattta tcgttattat caagggtttt atcatgtaaa 3234061 agccctcatc atagacgacc atctcagcat tatcggaaca gccaacttcg ataaacggag 3234121 cctgttctta aatgaagagg tgaatgttga aattgatgac gaagcgttta caagtgaagt 3234181 ctatgccaca attgaggagg atatgaaaaa gtcggagctg ctgacgatgg aggatttcag 3234241 caagcgcaca ttcaggcagc gcccggcgga atggctcggc agggcattat cttatttctt 3234301 ataaaggaga gttcctatga ttttcagatt cgggttcgtt tcaaatgcga tgagcctttg 3234361 ggatgcgtct cccgctaaaa cattgacatt cgcgcgttat tcaaagcttt caaagactga 3234421 aagaaaagaa gcgcttctga ctgtgacaaa agccaatttg cgcaatacga tgagaaccct 3234481 tcactatatc atcggccacg gcattccttt gtaccgtttt tccagttcga ttgtgccgct 3234541 ggctacgcat cccgacgtga tgtgggattt tgtaacaccg tttcaaaaag agtttcggga 3234601 gattggagag cttgttaaaa cccatcaact gcgaacaagc tttcatccaa atcaattcac 3234661 tctgtttacg agcccgaagg aatccgtcac aaaaaatgcg gtaacagata tggcgtatca 3234721 ctaccgcatg cttgaggcca tgggcattgc tgatcgctcc gttatcaaca ttcatattgg 3234781 cggcgcttac ggaaataaag acaccgccac tgcacaattt catcaaaata taaaacagct 3234841 gccgcaggag atcaaagagc ggatgacact tgaaaatgat gataaaacat atacaacgga 3234901 agaaacgctt caggtctgtg agcaggagga tgttccgttt gtctttgact ttcatcattt 3234961 ttacgccaat ccagacgatc acgccgacct gaatgtagca ctgccccgca tgatcaaaac 3235021 gtgggagcgg atcggccttc agccaaaggt tcacttgtct tccccaaaat cggagcaagc 3235081 gatacgcagc cacgccgatt atgttgacgc caactttttg ctgccactgt tggaacgctt 3235141 taggcaatgg ggaactaata ttgatttcat gattgaagca aagcagaaag acaaggcgct 3235201 tctccgcttg atggatgaat taagctccat ccgcggtgtc aaacgcatcg ggggcggtgc 3235261 gctgcaatgg aagtcataaa tgtgcaaaaa taggtttacg acttgtcagc tttgggaact 3235321 taggctatat aagacaacaa tcgatggagg agaaagatca tgaaaaatat caagtctctg 3235381 aaagtagccg cacaggcctt tactttaaga aatttgattc atctttataa aatgtgccat 3235441 tccggaagcc acgaggttta tatttattca aagaaaacga tgtgcaaaat caaaagctta 3235501 attgagcttg aaacgttccg catggctcat aatgaaaagg aatatctgat cgtagttgaa 3235561 ggaacaaaag catcacagct cattgaaaaa ttccaaaatc tcatcgagcc tgctgagaga 3235621 gaagcgctct aacttacata caaaaaagga tagacatctg tctatccttt ttcttatgct 3235681 cttacataat ggagctgaac cgcttgtcca aattgttttg tcccttttaa ccgcagtttt 3235741 gtttcatttg ttagttcgtg aaacagcggg atgccgcttc ctaaaacgac gggaataaca 3235801 gtgatgatga attcgtcgat ggcatcttct ttcataaagt cattcacaag ctctgccccg 3235861 ccagctatcc agatgtttga gcctttttcc tgtttcaaac gggcagtgaa ggctctggct 3235921 ccctcattga taaacgtcac atgttcatct tgataactgt cgggcgatcc tgtaaaaaca 3235981 tagcaggttt tatcctgata cgggaaaacc ggtgttagca ctttaacgtg ctcatatgtg 3236041 ctccgcccta aaatgactgt atcaacagtc tgataaaaat cactgtagcc gttgtcacct 3236101 tcaccttcaa attcatccag ccaatcgatg cttccatctt cttttgcgat catcccgtcc 3236161 aatgaaacag caatgtacag cacagttttt ctttccatgt tctcctccta tcgatgcacc 3236221 atttgcccga attgcgcttg atgcagcctg ctgtataggc ctccggcttc gatcaggtct 3236281 tgatgacggc cttgttcttc aataccgttg tttgtgacga ctacaattct gtccgcgtct 3236341 ttgattgttg ccagcctgtg ggcgatgaca agcgtcgtgc gcccctcaga caactcttga 3236401 agcgcctttt ggatcgccgc ttccgtctct gtatcaaggg ctgaggtggc ttcgtcgaga 3236461 atcaagatcg acggattttt caagaacatc cttgcaattg acagacgctg tttttgcccg 3236521 ccggaaagct tcacgccgcg ttcgccaatc atagtatcca acccatcggg catgttatgg 3236581 acgagctctt ccagatgcgc ctgcttcaca gcttgccaaa tgtcttcttc tgatgcgcct 3236641 agtcggccgt aggcgatatt ttctctaagc gtgcccgaga ataagaaaac gtcctgctgc 3236701 acgacgccaa tctgcccgcg caacgaagaa agcgtcatgt cttttatact gatgccgtca 3236761 atcgtaatgt cgccctccga tgcttcataa aaacgcggaa gcagactgca aagcgttgat 3236821 ttcccagcac ctgacggacc gacgaacgcc accgtttccc ccgcttgaat ggataggttg 3236881 atgtcattga ggacattgtg atggtcatca tagccaaacg aaacatgttt atagcggata 3236941 ttgcccttca ggccggaaac atctttcgaa tcaggtgagt cctgaatatc cggctctgtc 3237001 tccatgagct ccatatagct tttgaaaccc gcgatccccc tcggatacat ttcgataatg 3237061 gcattaattt tgtcaatagg cctgaacagc acattcgtca agagtacaaa cgccacaaat 3237121 tccccgtacg ataaggagcc gcgaatgaca aaccacgtcc cgcacaaaag gacaaacagc 3237181 gtgacaaacc gggtcagcat atagctgatt gaaccgtttt tcgccatgat tttgtaggaa 3237241 gaaagctttg tgacacgaaa acgctggttg ttgacggcga agcgttcttt ttcaaatgct 3237301 tcatttccga acgcctgcac aagccggatg ccgccgatgt tattttctac acgcgcgctg 3237361 aagtctccga tatccttgtt cagcgtggta aatgctttgg tcattttttt gttgaaataa 3237421 agcgctagcc aaatgacgat cggcataatg ataaacgtta ataaagcaag ctgccagtta 3237481 ataaacagca tcactccgaa cgccccgaga atggtcatga ccgcaatgaa taagtcttcc 3237541 ggtccgtgat gggcgacttc accgatatac attaaatcgt tcgtgagctt cgacatcagc 3237601 gttcccgtct tgttgttgtc gtaaaatttg aacgagagct tttgcaaatg gtcaaaaagc 3237661 gactttctca tatcagtctc aatattgata ccaagcatgt gtccccagta ggtcacgata 3237721 tactgaagag ccgagctgag cgcgtacacc gcaaataacc cgattgaggt cgcgatgatc 3237781 agtccccagt ccctgcccgg cagcaaggta tcaataaaat aattgacgat caaaggaaaa 3237841 ctcagctcca ttaaacctcc cgcgatcgct gagaaaaagt cgagaaagaa caacgtttta 3237901 tatggtttat aatatgaaaa aaattgccgc agcaccctat cttcccccaa tgtataaata 3237961 actgataata tttctcaatt atactataca cgggctgttt tgtaagatca gatttctttt 3238021 ttcttacaga acacctgaaa acaggcgggc aaacgactct tttgtccggt cagccacacc 3238081 tcttttataa aagccgacag ggctgagctt ttcactttcc tgcatatcct cttcaaaatg 3238141 ggcctcaagg gttcggatcg cttcggcatc cgtgaagaac acattcactt caaagttgag 3238201 ctgaaagctg cgcatgtcca tattcgcggt accgacggag gcgagatcgc catcaatgat 3238261 catgactttt tgatgcatga agcctttttg gtaggagtac acttcaatgc cctcaaggag 3238321 cagctccggg aaataggacc tcgacgcgta ttgggtcaaa aagctgtcgt tcttctccgg 3238381 caccataacc cttacctcta ccccctttgt cgccgctgct tttagcgccg tgcgaatgga 3238441 ttcattgggg acaaaatagg gcgtggcgat ccatattgat ttctgcgctg aagaaatcat 3238501 ttcataataa aggtcgctca tgctttcctt catgtcaggg cctgtcgcga caatttgata 3238561 aatgcctcct ccttccacgg gaaccggggt attgtactcc tcttgatcaa ttagcacttc 3238621 attggagaca tattcccaat ccagcataaa gatagcgtgg agcgtttgca caatttcccc 3238681 ctcaagccgc aggtgtgtat ctctccaaaa tccgatgtac ggatctctgc tgatatattc 3238741 cttcccgaca tttaatccac ccacaaaacc ggttttccca tcgatgatca cgattttccg 3238801 gtgatttctg aaattcagct tctggttgaa aaacccgtat ttcagcggag aaaacgggac 3238861 gatgtccacc cccgcttgtt tcattctcat aatatctctt cttgccagct tcatgcttcc 3238921 tgccgcatcg tataaaaacc tcacctcgac accctggcgc gctttctcca tcataatatc 3238981 catcatgccg cgtccgagca tgtctgattt aaacatgtag tattcaatat gtatgtaaga 3239041 ttccgctttt ctcattgctt tgaaaatgtc cgggaaggtt tcttcgccgt ttttcagcac 3239101 tttgatgttg cttttcgtat tgatattcat atgggcagcc ctgatggaat atgtaaagaa 3239161 cctctcttga ttgtccttca gccctgtcac ttcgggcgtt tcctccttgt caaacagctt 3239221 cctgagcttt tccctgttgt acattcgttt tgtcttaaac agctttccct ttacataaag 3239281 ctgtcccgaa aacagataaa acacgtagcc gacgattgga aaaaagacaa gaatatggat 3239341 ccatagcagc gtgtgctgcg aggtgcggtt ttcaagaatt aatgaataga tgctgaacaa 3239401 aataatgctt atatagcaaa gcaatcctcc gtaaaactca agtctggaaa ccggaaaaaa 3239461 ccaaatgaca tatgccccga tgagcatcat atataaaaag aaaaattcca gtctcctttt 3239521 cagcatcctg attctctcca atctgattca attacctctg tattacctct tttttctaat 3239581 cgataaacct tgtaagtaaa aaacctctcc gccaaaggag gagaggttta gagaaaacta 3239641 actgtcacgg aattcatccg catcgtttct gcagaaataa agcaagacta ttggcaacgc 3239701 cgagtgacaa catgagcggc aagctgaacc cgctcagcac tccggcaagc gccgaaaaga 3239761 aggcggcgct gtgactgcaa atacggtgga tagagtaaat ttgataccca ttctgatgag 3239821 agaaaatata taaaacggga aattgatcag aaagatataa ggagttagtc aggctgaatc 3239881 ataatctggc tgttccgccg gtttaaaatg agtaaaatcc ttgatgttat ttccatatac 3239941 aaacataaca ggattcccgg cagcccagcc attaccttgg cagaaaaaac cccctcttgc 3240001 aagggggatt ttcacgagcg tttccgatat acaacgtagc tgcgggtcag atacttgagc 3240061 ggcagactga acacatgaac caatctcgta aacggccaca ggataaaaac gacgtatcct 3240121 atcacaatat gaaacttaaa ccatagcggg acactctcca tcaaagaggc gtcaggcctg 3240181 aacaaaacga tttccctgaa ccagggcccg actgtggtcc ggtaatcaaa tcctttcgaa 3240241 tcaatgttga gaaacgtggc cgcaacgcct gacagcatca tgaacagcag caggaggagc 3240301 gtaaggatat cggatggcga gctcgttttg cggattcttt tgtcaaacag ccttctgtac 3240361 gtcaggatga caagtccggt acatgccgca atgcccgccg gcaagccagc gccaatcgcc 3240421 attttgtgat acatatgctc tgaaatgcca agggaagcat acacgccttc tgggatcaga 3240481 atccccatga catgcccgcc gacaacgcac agcagtcccc agtgaaaaag tgtgctgcca 3240541 gccgcaagtt ttttcttttc taacagctcg cttgatttcg ccgtccagcc aaattggtca 3240601 tgctgatagc ggtaaatatg gccgccgata aagattgtca atacaatgta tggcataata 3240661 ccccagagga tctgcccgct catgcctgaa cagccccttc aacgctttca cgtacgccaa 3240721 tgttttcaag cgcggccagc agcacgtgca gcagttcagc gtatatactg tcattttttt 3240781 cgagacggga tgccagctcc ctcacattgg acagatattt ctcaaacacg cttctcgctg 3240841 cttcaatttc tgcagccgca gcaaattcca gcatcagcgg cagataatca ggcagctctt 3240901 tctctgtcgg caggaaaccg gattgctcgt atgtgttttt taaatgcagc aattcaatgc 3240961 cgcgttccct ttgctcgcct gagttaaagt aggtgacata catatttgtt tttttcccga 3241021 agtcgaatgt atagacatag tgttcaatca gcgcttccgg agaatagctg gctgacgtct 3241081 cgaaaaagtg cagcagcttc tcccggattt gccggttgcc gatttcttgg ataagagcct 3241141 tccaatcggg aagctcggct ctccactctt catccggata agagagaaga caggaaagag 3241201 cagagaacgt gatttgccgg tctgtggtgt tcatcttgtt acacctcatt tatcaaaagt 3241261 tagaaacagg agccggggcc gcctgaaaat gataagccgc agcttccttg ttcagcgtat 3241321 aaatctgata cttcttctcg atggctgctc ggaatcacaa agcggtcatc atatttggca 3241381 atcgcaagca gccgatacat atcttcaatt tgctgttctg ttaagccgac actggagatc 3241441 agttccggat cgattgattt attcgtctgg accgctctca tatactggcg catgacagac 3241501 attttcttta atgttgaccg aatatgatcc gtatcaccgg ctgttaacag ctgcgccaaa 3241561 taatctatcg ggattctcat ttggtcgata gccggaaaaa tatcttccgc cgtttgccgg 3241621 ctgccttttc cttcaaagag attcataatc gggctgagcg gcggaatgta ccacaccatt 3241681 ggcagcgtgc ggtactcagg atgaagcggc agcgcgatct tccagtcaat gatcatttta 3241741 tagatcggtg attgctgcgc ggcctctatc cattcagccg gaatgccttg ttcttttgcc 3241801 agtttggcaa cctcaggatc attcggatca agaaaaacgt ccaattggga atggtagaga 3241861 tccttttcat tttcaacaga tgccgcttcc tccactttgt ccgcgtcata tagcatgacg 3241921 ccgaggtagc ggattctgcc aacacacgtc tcagagcaga tggttggcag tcccgcctcc 3241981 aaacgcggaa agcagagtgt gcatttttcc gctttgttcg tttgccagtt aaaatagact 3242041 tttttataag gacaggatga gacgcaatat ctccatgaac ggcatgcgtt ttgatccaca 3242101 agcacaatgc cgtcctcctc gcgtttgtac atggcgccgg atggacagga tgagacgcat 3242161 gccgggttga tgcagtgctc gcaaatacgg ggcaaataca tcataaagac gtcatcgaat 3242221 tctgttttga tcgattcctc catcttttgt acgttgggat cttcaagtcc cgtaatgtgg 3242281 ccgcctgcga gatcgtcctc ccagttcggt ccccattcga tattcatgaa atcccccgtc 3242341 aaggacgatt tcgggcgtgc taccggctgg tgttttttct gcgggctgtt cgttaatgtt 3242401 tcataatcat agttccaagg ttcatagtaa tcatcaattg acggctgatt cggattatag 3242461 aaaaggcctg caagccgatt ggttttcgag cccgatttca gctcgagctt tccttttttc 3242521 aatgtccagc cgcctttata tttgtcctgg tcctcccatt gcttcgggta gccgatgccc 3242581 ggctttgttt ctacattatt gaagtacata tattccgcac cggaacggtt tgtccacgtg 3242641 tttttgcagg tgacgctgca cgtgtggcag ccgatgcatt tatccaagtt catgaccata 3242701 ccgatttgcg ctttaatctt caagccaatc gacctccttc agcttgcgga tgacgacgtt 3242761 caggtcgcgc tgattccccg ttggaccgta ataattaaag ccgtagctga gctgggcgta 3242821 gccaccgatc atctgtgtcg gcttgacgtg aatccttgtc gggctgttat gggtgcctcc 3242881 gcggttattc gtcagctttg tgccgggcac gttgatgtgg cggtcctggg catggtgcat 3242941 aaacgccatt cctttaggaa tccgatgaga caaaacggct ctcgcgacga caacgccgtt 3243001 tcggttgaag cattcaatcc aatcgttgtc tttgatatcc gtgtcctctg catcatcttt 3243061 attcatccac acggtcggcc cgccgcggaa cagcgtcagc atcggcagag aatcaaaata 3243121 catgctgtgg acagaccatt tattatgcgg cgtcaaataa ttgaggacga tttcttttcc 3243181 ctcttgatca ggccgtttgc tcagaaacgg gcgatgctgg aggatcggtt tgaatgtcgc 3243241 catcgtttca ccgaattcca tcatcagttc atgatcgaca taataggatt gtctgcctgt 3243301 cagcgtccgc cacggaatta atttttcaac attcgttgta aacggcgaat acctgcgccc 3243361 tcctttttca gagccggtaa acgctggaga cgtgatcacc gttttcggct gggctgtaat 3243421 ttgttcgaac gtaaagcatt cttcctcgcg ttcttccgcc aggtctttca gcttcaggtt 3243481 cgtgatgttt tcaagtgatt cccatgcttt tactgcgacc tttccattcg aagtggatga 3243541 tagggttaaa atcgcttctg cagcctgctt tgcttcactt atatttggac atccctttgc 3243601 cacgctgtcc gaggtgattt ctcccagtct ctgtttgagt gattcatatt catcggctat 3243661 tgaccagctc atcccttttg ttccgctcgg ctttaaagca acgttcggac caagtgcagt 3243721 cattttatga aaaatgtgtt tgtaatcccg ttcaacgact tggatgttcg gcatcgtttt 3243781 tcccggaatg gcttcacatt cgcctttgct ccagtcattg attttgccga atggctgggc 3243841 caattcctgc atggtgtcgt ggagcagcgg tgtcgcaacc acttctttca ccggctccat 3243901 atcgacttct tctgccagat cggaaacggc ttttgacagc gccttgaaaa tatcccagtc 3243961 tgacttcgat tcccacggag ccgagatcgc aggagcaaat ggatgaatga acggatgcat 3244021 atctgtgctg ctgagatcgt gtttttcata ccatgtcgcc gccggcagca cgatatcgga 3244081 atacagcgcc gtacccgcca ttcgaaaatc aagattgatt aataagtcga gctttccttc 3244141 cggcgcctgc tcccgccatt tgatttcttc tgggcggatg ctgtcgctgt cgtcattcat 3244201 taaaccgttc gttgtcccca gcaaatgctt gagaaaatat tcatgccctt ttcctgagct 3244261 tgagatcaga tttgcccgcc atacaaagag attccttggg aaattcactt cattgtcagg 3244321 atcttcaatc gcgaatttca gttttttctc ttggagctgt gaggccacgt acgcacctac 3244381 gtcttcaggt gttgctgccc ctgctttttc agcttcttta tacagatcga tgccattttg 3244441 attgaaagtc gggtaagacg gaagccaccc tagccgcgcc gccagcacat tgtaatcagc 3244501 gtggtgcttg tagcgggatg aagcagcaat cggtgatgcc aaatcactga tcggctggtc 3244561 ctcataacgc cactgatctg tcgcaaagta gaaaaatgag gtgccatttt gcagcttggg 3244621 cacgccttcc cagtcctttg cagttgcaat cgtctgccac ccttcagcag gtcggagctt 3244681 ttcctgcccc acgtaatggg cccagcctcc gccgtttacg ccttgggcgc ctacaagtaa 3244741 aacaagattt aacactgctc ggtagatcgt gtcggagttg aaccagtggt taatgccggc 3244801 ccctacgata atcatggacc ggccgtctgt atcgatcgca ttttgggcaa actctctggc 3244861 aatcttaacg acagcttctt ttttgattcc tgtcatttgt tcctgccagg caggcgtaaa 3244921 cggctcaggg tcatcatagg agacagccga tcgttcgccg atgccccggt tcacgccgta 3244981 gttagccagt atcaagtcaa acacggtcgt gatgtacgtt tcttcaccgt tcaggttcat 3245041 ttttttaata ggaagatccc gctcgagcac tttgtttccg tcatttgaaa aatacgggat 3245101 gcgcaccgtg ccgatttcgt cctctattcc cagcacagag agacggggtt caatcggttc 3245161 cccggtttct tcatcaatca tgtgcaggtt ccatttctgc tgcccgtccc agcgcgagcc 3245221 cattgtccct tggggtatgg caaatgaact tgtctgttca tcccaaaccg caggcttcca 3245281 ctgatcatgc tttgtcttcc gcccgatgtc cttcgcatgc agaaaccgtc ccgctgtgta 3245341 tacgccattt tcttttgaca gagtgacgag aaatggaaaa tcagtgtatt gcttcgcgta 3245401 ctcaataaaa cgttcagttt cttggttcac gtaaaattcc tgcagaataa cgtgacccat 3245461 cgccatcgca agcgccccgt cagtcccttg gcgaatactc agccagtcat ccgcgaactt 3245521 tgaggattcc gcaaaatctg gactgatcga aatgacctta gcgcctttat agcgggcctc 3245581 cgccaaaaaa tgcgcgtcag gcgttctcgt taacggaacg ttggagcccc atgtgataat 3245641 atagccggaa ttgtaccaat cactgctttc cggaacgtcc gtctggtcac cccaaatttg 3245701 cggggatgct ggaggaagat ccgcatacca gtcataaaaa ctgagcatag ggcctccgat 3245761 taacgacata aaccgggagc ctgatgcgtg gctgatcatg gacatggccg gaatcggaga 3245821 aaaaccgacg tttcggtcag gcccgtattt catcactgta tacagcagag aggctgaaat 3245881 cagcttcagc acctccggcc attcagcgcg cacaaaaccg cctttccctc tcgcctgttt 3245941 ataggacttc gctttttcag ggttttcgac gatcgatttc caggcttcca atggattttg 3246001 atgcgtctgc aatgcctccc gccacaaatt gatcagcaca ccgcgcacgt atggatattt 3246061 cacacggagc gggctgtaga tataccatga aaaactggcc ccccgcgggc agcctctcgg 3246121 ttcaaaatca ggcatatccg ggcctgttga tggataattc aaattttgcc cttcccacgt 3246181 gactattccg tttttcacat aaatattcca gctgcaagac cctgtacagt tgacgccgtg 3246241 ggtggagcga acgactttgt cgtactgcca tctgtttctg tatacattct cccaatcgcg 3246301 atcctcgcgg gtagtttggc tatgtttatt tgaatggtgt tcgataggag agaaataatt 3246361 caatctccta aacaacggac tccttttctt tttcttcatg agagttcact ccttccgagt 3246421 caggtgatgc taagttcact ataaacagag acagcgtgtt tccttgtgaa ctatgtcaca 3246481 cactctgctt ttttcacaaa atgttcacac aaaggagaag gaaggctgcg ttcaggcagg 3246541 acgcttgggt cattagctgc ctttcattca aagatcaaaa aaaaccggct ctatttaaga 3246601 accgggctca gcgttttcat cctgtgatgt atgcagatac cgcaaaaata attgatagga 3246661 acaaaaaaca ttttgctgaa gcatagccaa aaagttcatt tgcagctgcg gatgataaga 3246721 catcattttc ttaaatatgt aatatgggat gttgagaatc agaatgtctg aagtggcatt 3246781 gactgagata aagggcgata aataaagccc gcctttttca tcaatcggaa acacatcgcc 3246841 tttttcccac agcgcaacgg ttttcgaccc ttcagggagc cttgtgtcca taaaacggac 3246901 actgcctttt aatacaatat aaacagattg agaatgaaga aaagatggag actgatcaca 3246961 tgaaccgcgg ataaacgtgc cgtttttcag caaggtttcg acaatggata gaggcacttc 3247021 attaaacata ggaagttgtt tcagaaataa taaatagtca cactgattca taggaaaacc 3247081 tcctgtgcta aggatagctt tagtgtagct cgactgagcc tgtacagcag tgatgtattt 3247141 cacagcctgt atgatgaatg tcacttatca ggagggtgaa tgcatttata atgaaagaaa 3247201 aaaggaggat ttcgatgaag gcgctgattc cgaagcagca cggggcgtgg gcgatgctgc 3247261 tgatcccatt tttactcggc atggtcaagg gaggccccgt tatttggcat attccgctct 3247321 tccttggttg gcttttccta tacttagcgg tttatcccgt tacgcttgcc ttaaaaaaga 3247381 aacaaagcaa accatatcaa aagtggatgt gttattacgg ttttcccacc tgctgctttt 3247441 tgatgatctc ggtctttcat aagccgcctc tcatctgggt gggcgtttct ttactgccgc 3247501 tgtttctcat acatatgtat tttgcccgca gaaaaaacga acgagcctta ttgaatgatg 3247561 ttgcaggtgt cttgttcttt tgttcgggcg ggtttgcgag ctgctggctg gggatgggaa 3247621 cccttgacgg ctgggcttgg tttattttct tgcagtctgc tttatttttt atcgggagtt 3247681 ccttttatgt gaaatcggtg atccgcgaga gaaaaaacag ggcatttgca tactggtcat 3247741 ggggatatca cctgctgctc ccctttttat ccgctctttt cggagcagga tgggcgtttc 3247801 tcgcttttat cccgagcagc ttgcgggcat ggttttttca tggaagggat tggcccgtaa 3247861 aaacgattgg cattctggaa atcgtgaatg cctgcttctt tcttgccgtc atgtgcctgt 3247921 ttatcacaag gtaaaaaaac aaggacaccg ctgtccttgt ttttttcagt caatattgca 3247981 aatctccagc gggcaatttt cacactcaat ctcacatcgt aaatagtccc gcttgtgcaa 3248041 aataattttt ccggattcgt ctatcgaaat aacccctttt ttgcggagat ctccgagcat 3248101 acgattgacg ctttcccgtg cagccgcgca aaactttgcc aaatcctgat ttgtcaggac 3248161 aatgttaatc agaatgccgt cgcttcgctc cactccgtag ctgtttgata agcggataag 3248221 ggtagaatag agcgccccct ttttgccatg aagaagcaga tccctgattt tggactgaat 3248281 cttccggagg tgcgtgctca tccatttcat gaactcaaat gtcaaagcgc cgttttggat 3248341 taattctttt tccagcttat ttttattaat gacgagcacc tcgccatcct ctagtacttt 3248401 tgcactgagc atataccttg gttcttcagt gaaaagtgtt aattctccga cgatatcatg 3248461 cttttggcag attctaagcg tcaggtcttt tccgtcagat gtcagcttgc cgatttcaat 3248521 gagtcctgat tgaatcagat aaagctcttc tgcatccatt ccttcccgaa acaaatacgt 3248581 gtgtttttcc atttttcttt tcgtgctgat cgattccagc aattcataca gatcgctgga 3248641 tataagatca ctatcagatg gtcgaacaga gagaaaattc atgagctcac ctcgaagaaa 3248701 gtcacgttgt gtgtttattg taacgtgaat tgatttgtac ccatcgagaa aaaactaaca 3248761 atcttgtgaa tgccccagtg ttagttgatg ctctggctgt ttctctccgt gtgtgttttc 3248821 attctttcct gccaatacat ccatatgaca aggacaaaac tggctaacgc cacctctgaa 3248881 agcgccataa acccgatcgc gtactggcct gttgcctgaa atacactcgc caatatgagc 3248941 ggaggaaaaa agccgcctaa accgcccatg gcagacacaa tcccattggc aatccccgct 3249001 tgcttcgaaa aatagaaagg caccagttta aaaacagttc cgtttcctat gcctgagcag 3249061 acggccacgg ttaatgatcc aaacgtataa aggccgattg tcggcgagaa cgataggata 3249121 atgcctgata atgtaagccc ggcaaaaaca aacatcaaga tgcggagcgg gctcatttta 3249181 tcagccagga atccgcccgc aggcctgagc agcgtagaaa ccgcaataaa gccagccgtc 3249241 cgcaagccgg catctgcagg attcagccca aaatgctcca ccagaaagtt cggcagatag 3249301 atagtgaagg cgacaaaggc accgaacgta ataaaataaa acaggctcag aaaccatagc 3249361 acatgatttc ggtaaacagc tttgatttga gtcttaacag aaactttgac cttcttctca 3249421 tgcctgtcgc caaacaatac gtgcagtaag gcaaagacag ccagcaaaat cagatacatt 3249481 tgcacggttg atttccaccc gacggcttga gcgataaccg gcgctgcaaa tgtcgtaacg 3249541 gctgtcccga tatttcctgc accgtaaatc ccattgacga caccgtgctt ttctttcgga 3249601 taatatttcg ggagggaggt caccccaatg gaaaacaccg ctcccccgat ccctaagaaa 3249661 aagccgcctg cgattaaatc aaacagagaa tccgcgatac tgatccaaaa tacaggaaat 3249721 aaaagcagga tgaagctgac cataaacatg agccgcgcgc caaacctgtt cgttaaatac 3249781 cctaaaggaa tgcggagaag cgacccgagg atcacaggaa tcgcggtcac taaagaaatc 3249841 tcacccttgc ttaaatgaat atctaatgtg atttgggaaa tgagtgatga aatcagcacc 3249901 caaaccataa accctgccac caagcttaat gactgtaacg ataattgaat gtgttgacgg 3249961 ttgatcattt ggcttgcccc tttcaatgat tcaataatca gtcttatcat acaaaaacta 3250021 gccaaacagg attgtgaatt acatcacacg tttttctcat aaaaaaagga caaagcccga 3250081 agactttgtc cttttgatcg tgattacatt ttttccggag ccgatacgcc gatcagctga 3250141 agcgcattgt tcagcgtaat ttgcgttgcc ttcattaaag ccaggcgcgc gcggcttttc 3250201 tcttcatttt cagggtcgat gactttctct gcgttgtaga agctgtgcag agcagaagcc 3250261 agatcataaa tatagttagt gacacggtgc ggaattcgtt tttccgctgc ttccgccact 3250321 gcctctggga agccgccgat cgttttcagc agatcgtatt ctttttctga ttgaatatgg 3250381 ctgaaatcaa gatctgccgc cggtttaagc ccctgctctt ccccttggcg aagcatgctg 3250441 caaatacggg catgcgcgta ttgtgcataa tacacagggt tttcgttaga tgttgataca 3250501 gcaagatcta agtcaaaatc catatgggtg tctgcacttc gcattgcaaa gaagtaacgc 3250561 acggcatcca agccgacttc ttcaatcagg tcacgcatcg ttacggcttt accggtccgt 3250621 ttgctcattt tcattttctc gccgtttttg taaaggtgaa cgagctgaat gatttctact 3250681 tcaagcgttc ctttttcata gcccagcgct tcgattgccg ctttcatacg cgggatgtag 3250741 ccgtggtgat cggcgcccca aacgttgatc agcttatcaa agccgcggtc aagcttgtcc 3250801 ttatgatacg cgatatcagg aagaaggtac gtgtacgtgc cgtccttctt gatcaatacg 3250861 cggtctttat catcgccgaa agtcgtggaa cggaaccaag tcgcgccgtc ttcttcatag 3250921 acgtggcctt tttcgcggag cgcttcaagc gccttgtcga tttttccatt ttggtacagt 3250981 gaagtttctg aataccacac atcaaacggc acacggaagt tttccaagtc cttgcgaagc 3251041 ttttccagct cgtatttcag gccgtattca cggaaaaacg cgaggcgttc actttcctct 3251101 tcgttaacga aacgatcacc gtattcctca gcgagacgct ttccgatcgc aatgatatcc 3251161 tcaccgcggt agccatcctc cggcatcggt ttttccaatc cgagtgcttc aaagtaacgg 3251221 acttcaacag aaagcgccag attgttgatt tggtttcccg catcgttaat gtagtattcg 3251281 cggcttacat cgtaacccgc ttttgaaagc acgttgcaca aggaatcgcc gacagccgcc 3251341 ccgcgcgcat gcccgaggtg aaggtctccc gtcggattcg ctgatacgaa ttctacctga 3251401 actcgttcac cgtttccgat gttcgtttcc ccgtatgctt cccctgcttc cagtacagac 3251461 ggaatcagct ttgttaaata ttgattgttc atatagaaat tgataaaacc cgggccggcg 3251521 atatccagtt tttcaatcga agccttccct ttatcaaaat gggcgacaat ctcttcagcg 3251581 atttgacgcg gcgctttttt tgccactctt gccaactgca tcgccatatt cgttgagtag 3251641 tcgccgtgtg ttttatcttt cggtgtttct aaaacaacat tgggaatctg gctttcttca 3251701 gccagtcccg ctttcagaac ggccgctttg atttcttctt tcagcacgtc cttcatttgt 3251761 tccgcaatgt tcatgcgtga gttcctccct catacgtgat cgtcatatta tgtaaatgct 3251821 cctgctcgtc tccgacatgc atgtcatatg cgatgctgat acggcctttt tcttcatcga 3251881 gatcagattg aatcgatttt gtgcttgttt tcagctcaag ctcaccaaat gacattttat 3251941 atttagcaat tgtggaagct cccgttacga aacgctgatt cattttgaca gcgcctgacc 3252001 tcatgaccag gacttcgcct tcgcttactt tcacaatcgt tttgactttg cctaagtcgt 3252061 gttcttcata ataagataga tacactttat tttgttttac atagtaaaat ccggtggtgc 3252121 ggaattcgat gacttcttgg tttccgtcat cctcgatcac agacttcaca tggagtgtta 3252181 tcggtgtctc ttgcttcatt ctgacacgtc cttttcatca ttccactttg acttgaatag 3252241 tataatcatt cggtttgtaa acttcaactg cttctatctt accatcattg ctcatcagat 3252301 ttgaagataa acctcataaa aagcatttcc ttatatagaa gagaaaatca tatcactaat 3252361 tacctttagg aaatgttacg agctcgctac atcgcaatcg cagacggacc cgcgccaacc 3252421 ggaatcaccg tcacggctgt ataatcactt gtgcggtaca cggtcacagc attgtcgttg 3252481 ggctgtgccg cataaatata ctgtttgtcc ggcgttacgg cgaggtcaaa ggcgccgggg 3252541 agagacacgt ttgcaatgat cctctgtctg gccgtattaa ctacgtataa gttattaatg 3252601 agaaacggtt cactatatgg ctctagaaaa taagctctag tactatcgag agaaaataca 3252661 atcgtcctca gcgtttcaaa taaacggctg aagtcccctc ccctgcttaa tggtgacaaa 3252721 ctaatctccg ttacaccttt cggccacagc tcaccattca atacgtacgc aaaatttcca 3252781 gcgtaaggag ttgtaattaa actgggaaat tcaaatgtat ctatgatact ttctaccaac 3252841 tgcccagtat ttacatcata tttatcaacc gaccaactgc ttccattagc ggtatagaca 3252901 tactgtccat tcggatcaag agcaaagtct aaagcgccgg gtatcggaat gacatcaatg 3252961 accgattgag aggccgtgtt aatcacatat atagatccgg cggccatcac gtatgcgaac 3253021 tcatctgttg gatcaaattc gatttttctc ggccctcctc caacagtaat ggtatttatg 3253081 atggttaatg ttttattatc aatcactgag acaaggttgg tatttccatg gaggacatac 3253141 gtgaatgctt tatcgaaagt aacgcctaga ttagttggca cgtcagaaaa agggattgtt 3253201 tttacaacag tgtttaaatc tgcatcaata accgaaaccg tgctgtctcc agtattggca 3253261 gtaaacacat acgattgagg gtctggtgat ggcggtaaaa caagtgtccc ggccaccgta 3253321 agcggactgc cgtagaaagg cggtacaatg agcagatctt ccactgttat ttgactgaaa 3253381 tcaggacagc ggccagactg tgctgcataa taaacaactt gatcaatctc ttcagtatga 3253441 atcacagaaa cagccccgtc tccttgtcca tattgatttc gtacaggcga cacactgaca 3253501 agaagcgtaa tggtcccttg tactctcaca gcatatcgaa caccgatatc ttctggttcc 3253561 ggcccagtct ggattaagca aggctcactg atacaggaca aattgtctgt actccatgta 3253621 acagccgctg acgcttcggc cgtatcaacc ttgaagccct cagggaaatc tatcggcact 3253681 tgaaacggcg cttcccggct aatttcctca tcacaaaaac agaaacaatt ttcctgtaaa 3253741 gcagaaagat cattcttttt catgatttca cgtcctttta gaaatgcaca acatgcagcg 3253801 gttaaatcgt aatggcaccc ggtgaaaccc caagagatat cacagtttcc tcagaataat 3253861 catctgtgtt gtaaacaatg atgctctgct ctataaaacg agttgcatac agaaaatcgc 3253921 cattcggggt aaacgcatag tctgttgctg attgcggaac atttcctata acgcctgctc 3253981 catttggact gacagaatat aaattgccag tgaagccgtc atataaatac acctctgctc 3254041 cactcgtaaa cattcgatat tccccttcat actccagctc ttgggtgctg ctgatggtaa 3254101 acgtatttaa atcaataacc gtcaaataat taaaaaagaa ttcttgttct aatacatagg 3254161 cataccgctc cggccaattt gtttctatgg ttgatacgat aagctctcgt tcaattgttc 3254221 ctgtgacttc accggtagtt aggtccactt tttgcactat tccaaaattc agaacatagg 3254281 cgaataaccc attgggatcg attgcaacat catatccttc cacaggaatc gacctatcca 3254341 cagttaacgt atcaattcca atcacataaa ccgcagtacc ggtgaaaaca taagcaaact 3254401 catgattagg gataaatcta atcaatcgag gcggctgatc cagcaatata gttgctgtca 3254461 ctgttaatgt gtcataatcg atgacagaaa tcacattatt gttgggatgt aagacaaaca 3254521 cagcgctttt atctggcgta atttcaatac ctgccggatt gtacggaaga gcaatcgttg 3254581 tcacaacagt atcggtgttt gtatcaatca cagaaactga ttgatcattt ggattcgctg 3254641 taaacgcgta gacgggttcc ggctccggta caagcacaat tgtccccgtc accgataaag 3254701 gactgccgta aaacggcgga acaacaacaa ggttctcaat cgtgatgtca ctgatatccg 3254761 ggcaatcatc cgattcatcg gaataataga cgacttgatc gatttctgca ttgtgaatga 3254821 cggaaacagc cccgtcccct tgtccatatt gatttcggac aggtgagaca ctgacgagta 3254881 gcgtaacggt tccctgcagg cgcactgcaa attgaacacc gacctcatca ggctcaggcc 3254941 ccgtttgaat taagcaacgg tcactgacac aagaaaggct gtctgcattc cacgtcacgt 3255001 ttgcaacagc ttcagccgga tcaacgacaa acccttcagg taattcaatc ggtgcttgaa 3255061 acatggcttc tcggcttgct tctccctcac aaaaacataa gcactcttct tgttctgctc 3255121 ctgctttttc tttaaaggaa agcttgtttt ttctcattcc ttcacttcct tttcagacat 3255181 acactgctca cgcagatata acagaatatg gaagggtaac gtgtttgctt gtacaaattg 3255241 ctgagggtaa acgcttcttt ttgaaaatat atctccaaac atgcggtgta acgaaagaaa 3255301 aaattgcggt ttttttgcgc ttctcacaag aatgttgatg ataaaatatg acatatatag 3255361 aattatgaag ggagggattt gcaaacgtga caggtgtcat atcttcttct tccatcggag 3255421 aaaagattaa cgaatggtat atgtacatac gccgattcag catacccgat gcagaatatt 3255481 tgcgacgaga aatcaagcaa gagctggatc aaatggaaga agatcaagac cttcatttgt 3255541 actattcact gatggagttt cggcacaacc taatgcttga gtaccttgaa ccgttagaaa 3255601 aaatgaggat tgaggaacag ccgagactgt ctgatctgct gcttgagatt gataaaaaac 3255661 aggctcgttt aactggtctg cttgagtact attttaactt cttcagaggc atgtacgagc 3255721 tggaccagcg ggaatatctg tcggctatta aatttttcaa aaaggccgaa agcaagctga 3255781 tattcgttaa ggatcggata gagaaagctg agtttttctt taagatgtct gaatcttatt 3255841 actatatgaa acaaacgtat ttttcaatgg actatgcacg gcaagcatat gaaatataca 3255901 aagaacatga agcttataat ataagattgc tgcagtgtca ttctttattt gccaccaatt 3255961 ttttagattt aaaacagtat gaggatgcca tctcacattt tcaaaaagct tattctatgg 3256021 cagaagctga aaagcagccc caattaatgg ggagaacttt gtacaatatc gggctttgta 3256081 aaaacagcca aagccaatat gaggatgcca taccttattt caaaagagca atagctgttt 3256141 ttgaagaatc aaatattctt ccttccttac ctcaagcgta ttttttaatt acacagatcc 3256201 attataaatt aggaaaaata gataaagctc atgaatatca tagtaaggga atggcttatt 3256261 cacaaaaggc cggagatgta atatatttat cagagtttga atttttgaaa tctttatact 3256321 tatcaggccc ggatgaagaa gcaattcaag gattttttga ttttctcgaa agtaaaatgt 3256381 tgtatgctga tcttgaagat ttcgctattg atgtggcaaa atattatcat gaacgtaaaa 3256441 attttcaaaa agcttctgct tattttttga aggtggaaca agtaaggcaa cttattcaag 3256501 gaggagtgag tttgtatgaa attgaagtct aaactattac tctcttgtct ggctctaagc 3256561 actgtgttcg tggcaacaac tattgcaaat gcacctacac accaaattga agttgcacaa 3256621 cgaggaatga tttaaccgcc gtccatcggc ggttttttcg tcccctcttt accaaagtct 3256681 cccaatccat gctatgatct tttcaataat cttgaagaga gtggaaatgc agcatgtctc 3256741 taaaaagtgt gagaacccac tttactcaat ggaatcgaga aaatgatgtg acggagttcg 3256801 aaacgtcgag tgcgacagtt gaacaggcag ctgagacaat cggcgtaagc ctgtctagaa 3256861 tcgccaagtc cctgtccttc agaggggaag gagatcaggt gattctgatt gtggcagccg 3256921 gcgatgccaa gatcgacaac aaaaagtcca ggcaaacatt tggctttaaa gcaagaatgc 3256981 tctctcctaa tgaggtgctg gagcagacag gccatgaaat tggaggagtt tgcccatttg 3257041 gattggctca tgatcctgag gtttatcttg atgtatcgct gaaacggttt cagactgttt 3257101 tccccgcatg cggcagcaga aactccgcta ttgaattaac accgaaagaa ttatccgaat 3257161 tttctttctc aaaagtgtgg attgatgttt gtaaagactg ggaataaaaa aacatccaga 3257221 catcgtctgg atgtttactt atttcacaaa cccaagcagc atttcacgga tgattttgct 3257281 ggctgtgttt gccgtttgct ctgagtggtc gtataccggc gcgacttcca ctaaatcagc 3257341 gccctttacg tttacctctg aacgcgcaat ttcatggacc gatgcaagca gttctttaga 3257401 cgtgatgccg ccggcgtcaa ccgttcctgt acccggtgcg tgtgcagggt ctaatacgtc 3257461 aatgtcaatt gtgacataaa ccggacggcc cgccagcttc ggaagcacct ctttcagcgg 3257521 ttcaagcact tcaaattttg agatgtgcat gccgttttcc ttcgcccatt caaactcttc 3257581 tttcatgccg gaacggattc cgaatgaata cacattgtgc ggtccgatca attctgccgc 3257641 cttacggatc ggcgtggagt gagaaagcgg ttctccctca taatcaacac gaagatctgt 3257701 atgtgcgtca aaatggataa tcgcaaggtc tgggtatttc ttgtacatcg ctttaatgac 3257761 aggccatgac acgaggtgct ccccgcccat acccattggg aacttccctt tttctaaaat 3257821 gctgtccacg tactcttcaa tcatatccag gcttcgctgc ggatttccga acggcagcgg 3257881 aatgtcgcca gcgtcaaaga agttcaagtc agccagatcg cggtctaaat atgggctgta 3257941 ttcctcaagg ccgattgaca cctcacggat tctgcttgga ccaaagcgtg agcccgggcg 3258001 atagctgact gtccagtcca tcggcatgcc gtaaagaatg gcgtccgcct cttcccactc 3258061 gggacggctc gcgataaata cttttcctga ataagcttca tcaaatctca tctataatac 3258121 cctcgctttc ctgtaaaaaa gcgcaagatt cgctcctgcg ccataccttc attatttaat 3258181 caggtcactc acaaatttcg gcagaacaaa cgccgcttta tgaatatctt ttgtgtaata 3258241 tttcgtctca atatcgaaga aacggctgtc ttccactgca agcggatcat attttttcga 3258301 gccaattgta aatgtccaca aaccgcttgg atatgtcgga atgttcgccg tatacagctt 3258361 cgtaatcggg aagatttcct tcacgtcgcg ctgtacattt gtgattaatt ccggtgtaaa 3258421 ccatgggttg tccgtctgcg caacgaaaat accgtcttct ttcagcgctt ttgcgattcc 3258481 tgcgtagaat ccttttgtaa acaggtttac agccggtccg actggttcag tcgaatctac 3258541 catgatgacg tcatattgat tttcagattt tgcaatgtgc ataaatccgt catctacctg 3258601 cacgtcaacg cgcggatcat ccagtttgcc tgcgatagaa ggaaggaact ttttagagta 3258661 ttcgataacc ttgccgtcaa tatctacaag tgtcgctttt ttcacgcttg ggtgcttcag 3258721 gatttctctg ataacgccgc cgtcaccgcc gccgactacg agaacgtgct ccggatttgg 3258781 gtgcgtgaat aatgggacat gcgccaccat ttcgtgataa acgaattcgt ctttttcaga 3258841 tgtcatcacc atgccgtcca aaaaaagcat gttgccgaac tcttctgttt ccaccatttc 3258901 taaatgctga aactccgttt gttctgtatg taacgtcttg ttaaccttca tcgtaatgcc 3258961 aaagtttttc gtctgcttct ctgtgtacca aagttcgctc aattgtcatc tccctttcga 3259021 ggctgtattc atttattgta agcgtcttat cagcttttat tctcggttga aatctcattt 3259081 tcacctaagg aaaaagtata gaggatggcg gggaaaaagt aaagatgcgt cctgttctgc 3259141 gatgtttaaa aacgatcttt ttttctcata atagtagaaa cataaaaaaa gggggaaccc 3259201 gttgtggatg caatgacaaa taaacggctg agactgacgc tgaaaaccgt tcgcgccttt 3259261 atctttttag gggcttttgc ggccttggcg gcagctgctg tgtttatgac tgtcattttg 3259321 atagccaaat accagggcgc tccctcggtg caagtgccgc aatccacgat tttgtacgcg 3259381 agtgacggct caaagctcgg ggaaacgaac tacggcgaaa agcgctattg ggtcccctta 3259441 aaggacatga atccgacgat cgtaaaagcg acagtggcga ttgaagacca gaatttctac 3259501 gatcatcacg gctttgatta taaacgcatg gccggcgcgg cgcttgctga cctgaaagca 3259561 tttgccaagg ttcagggtgc aagcaccatc acccagcaat atgcgagaaa cttatacctt 3259621 gaacacgaca aaacgtggaa acggaaatgg aatgaggcgt tctacacgat ccgtctggaa 3259681 caaaactatt ctaaggacga gatattagaa ggctatttaa atacgattta ctacggccac 3259741 ggcgcctacg gcattgaagc agcttcccgc ctgtatttcg gcaagcatgc caaaaacctg 3259801 acggatgcgg aggcggcgct tttggcagga atcccgaaag gcccttccgg ctattcaccg 3259861 tatgtcaatg agacgaaggc caaggaacgc cagaaaacga ttgtgcggat gatggaaaag 3259921 cagcagatga tcagccaaaa gaaagcggat gaattgatca aggaacctct ttcctatcag 3259981 cctttgaata aacaagtttc caagagaaag gctccttatt tctacgacaa tgcgatgaga 3260041 gagctggaaa aaaagctcgg catgacacgg gagcaaattg aaacgagcgg gttaaacgtc 3260101 tatacaacgg tagataaacg gatgcagcgc atcgccgagg agaccattac cgaaacggtt 3260161 aacgcgggct ctgacattca agtcgggttt tcagccattg atccccgcac cggaaacgtt 3260221 ctcgcccttg tcggcggcag ggattatcaa aaaagcccgt ttgaccggac gacacaggcg 3260281 aagcgccagc ctgcttcgac gatcaagccg ttgctgtact ataaagcgat tcagagcgga 3260341 tttacgccag tcactttgat gaaaagcgaa gaaaccgagt ttcaaattga tgcaaaggga 3260401 gaaacctatt ctccaagcaa ctataacgga tactatgcca acaagccgat tacgcttctg 3260461 caggcgctgg cgctttccga caatatttac gctgtgaaaa cgcatctttt tctcggcacg 3260521 aacaaacttg taaagacggc aaaggaattc ggcattaccg cccatcttca agcactgccg 3260581 tccctggcac tcggcaccga acccgtacgt ccgattgaga tggtcaacgc ctatgccatg 3260641 ctcgcaaatg gcggaaagaa aatcgaaccg acttttattt caagagtaac ggacgcagcc 3260701 ggccacgtgc tgtacgaaaa cccgaatcag cataaacagg tgcttgatga aaaagccgct 3260761 tttgtcacag cgagtatgat gacaggcatg tttgatatcg atttaaatgg atatacgtcg 3260821 gttacggggc gaacgatagc caaccgcctg acaagaacgt atgccggaaa atcaggaacc 3260881 accagcgcag acagctggat gatcggcttc aatccgaagc tggccgccgg tgtttggacc 3260941 ggctatgaca aaaacagcac catcgactcg gtcgaagaaa aaagctatgc taaaaccatt 3261001 tgggcggact tcatggagga cgcgctcaaa ggcgaaccgg aaaccgcgtt caagccgcca 3261061 aaaggcgtaa ccggtgtgta cattgatccg gaaacaggct actcatcagg tcccggctgc 3261121 gccgctaagc attacacata ttttgtgaaa gggacagaac ccgcaaacgt gtgctacggg 3261181 gcagaacccg caaaacaaac aaaagaccgg cttccatcca aagaaaagcc cgcttccgag 3261241 aaaaagtggt gggacaaatg gctggggcga catcattgaa aataacccgg ctcctcggag 3261301 gccgggttat tcgtatggtt ccttcataat cgatggaaga atgttagaca atcgagctga 3261361 acaatcagtt ttgggataaa gtggtgaatt tctcatttct tcggcgctgg ctttcatctc 3261421 ccagtcgccg actcatatcc ccctaaaaat gaaaaacccc gagtcttgtt tcggctcggg 3261481 attttccatg tcctatttct gtatcaccag tttactcaat gtttacgaaa aatatctcaa 3261541 atactttaaa agttcacaaa aaattcataa attaattgtt ttctggaagc aggctcgttt 3261601 ttaactcatc tgaggaacgg tcccataggc cctgatcatg ctttttcaga aattcgccta 3261661 gtacacgctt cgagctgtcg tccattttat caacgatgat tttccgtttc atggatttat 3261721 ccatcagatt cacatgctca ggcagtgact tgtagcctct tctgatgctt ctgtcgaccg 3261781 tcatttcaca ggctgtcaca ccagcgtaat aaggcccctc ttcttttctg tcaatcgtta 3261841 cccacacaag ccagtatggt tttccgttcg gcacttcttc tttattcggg agaaatttaa 3261901 ttcctttttc aacggtgctg cgggcatgca tagcgccgat gtctacgaac gcttcttttt 3261961 cctctacatc aacgaatacg ggagaaatgt tatcaaggct gagtgcccct acgccaaaac 3262021 cgccgtgtcc gtctgtcgga tcacttttga taatattaaa cccgattgat tttttctttt 3262081 tttcttccat gaagttctac ctcctacaaa agcggttgaa atatcgctga aaacagcttt 3262141 aaaatcgaat ctcttcctgc attgagcatc ggccacagca cgtaagatcc tagcggtgtc 3262201 acaaacagca ccaaaaatac gataaagccg tagctctccg cctgcgtcat tttggcacgc 3262261 acgcccggcg gaacgagatc ttctataatt cgatagccat cgagcggagg aagcggcagc 3262321 agattaaata aaaacaagac aagattcagc tgtatccaaa tagaaaaaaa ctgatccagc 3262381 cccgtgctga acgccgcaag catttccatt ccgtacgcat gcatcaacac taacaaaaag 3262441 aaaccaataa acgcaagaat caggttactg acgggcccgg ctatagatac gagcacacca 3262501 gcaagccggg gtttcttaaa gaaacggcga ttcacgggaa tggggcgcgc ccacccgaat 3262561 ccggccacca gaatcaaaat ggttccgaac ggatcaaggt gtttaatggg attcagcgtc 3262621 agtcttcctt gttttttcgc cgtatcgtca ccgaatttgt atgcgacata agcgtgggca 3262681 agctcgtgca tcgtaaacga cacaattagc gtgatgacga ggtatggcat taaagataac 3262741 ggataatata aaaaacggtc caagtgagat atccctcttt ctcaaaatgc aagaatttac 3262801 tttattcagt atactataag aagcctcttt ttctaaagag aggaaacgag ataaaggagg 3262861 attcagcacc catgccatac gtaactgtca aaatgctcga aggccgtaca gacgagcaaa 3262921 aacgcaatct tgtcgagaaa gtaacagaag ccgtaaagga aacaaccggt gcttctgaag 3262981 aaaaaattgt tgtctttata gaagaaatga gaaaagacca ttatgccgtc gcaggcaaac 3263041 gcctgagcga tatggaataa tctctataaa gccggcgctt cgcgcaccgg cttttattat 3263101 ccctattgag ccagcttcgc aataatcgcc aagaacgtct ttttctcttc ggctgttaaa 3263161 cgttcaaaca tgccatcaat cagctgctgg cggttttcga tcatttgttc agccgctccc 3263221 cggcccgatt cagaaagagt aatccataca gtgcggcggt cattgttatt tctggatctc 3263281 tcaataaacc cttcctgctc taaatgattc agagctgtgg tcgtggcaga gggagacagt 3263341 gtgacctcct tcaaaatatc ctttatggtg cagctcccat gtctgtatat gatccgcaga 3263401 ataaaccctc ttacattatt cacgtgtttc ggaacggtgg cttcatctaa ttgcttcgtg 3263461 cttttcaaat actttgtaag tgcgtgatcc agcaaatttg cttccagttt gtcatggtcc 3263521 atgtcaattt ccccatttcg agatgcattc ataacatacg aacgatatga tttacttatt 3263581 attttactga ttccgaatag ggaaagtcaa aaaagcaaaa tgtgaattca cagcttttat 3263641 cctacatgcc tcgattttcc acctgtttca caagtttatc tttaaaagtt tggaaaggaa 3263701 cgtgttcatt ctgctgatgt ccgaatcggc ggacgtttac cgcattctcc tgctcctcat 3263761 gatctccaag caccagcacg tacggaattt tttgcacctg cgattctctg attttatagc 3263821 cgagcttctc attgcgctca tcaatgccgg ctcttatccc cgcctgcttc agctccgcct 3263881 gcacttttct gcaatagtct aagtgaacgt gcgaaaccgg tatgatttga acctggatcg 3263941 gtgcgagcca gactggaaaa gccccaccgt aatgctcgat caaaatgccg aagaaacggt 3264001 cgattgagcc gaaaaccgct ctgtggatga caacgggacg aaccttctca ttgagttcgt 3264061 tgatatatgt taaatcaaat ttttccggca tttgaaaatc aagctgaatt gtcgcgcatt 3264121 ggtggctccg tttcagggca tcttttatat ggaaatcaat tttcggcccg taaaacgccc 3264181 catcgccttc attgatctca taagagaggc caagctcctc aaggacgcgt gctaaggcac 3264241 gttccgacgc ttcccaaagg ctgtcatcgc ctaatgaatc ctccgggcga gtcgaaagct 3264301 caacagaata ctcgaaacca aatgtccgat atacctcatc aatcagccga atcgcttctt 3264361 tgatctcact ctcaatctga tcctcccgaa cgaaaatatg ggcgtcatcc tgacagaacg 3264421 tccgaacgcg aagcattccg tttaaagcgc cgctgtattc atggcggtgc acctgtccga 3264481 attccgccat gcgaatcggc agatcccgat aagaatacag gctgttttta aagatgagca 3264541 tgtggccggg gcaattcatc ggcttcattg cgaatcttgt atcatccact tctgaaaagt 3264601 acatattgtc gcgataatgg tcccaatggc ctgactgctc ccataaccgc tgattcatca 3264661 taaacggcgt acgcacctca tcgtagccgg catttgtttg cagctcacgc gagaagcgct 3264721 ccagctcatt gcggacaatc tgccctttcg gcaaataaaa cggcatcccc ggcgcttctt 3264781 cagaaaacat aaacagccct aactgtttgc cgagcttgcg atggtctcgt tttgccgctt 3264841 cttctagcat atgcaggtgc gcatccaaat cttttttctt ttgaaacgca accccgtaca 3264901 cccgctgcag gacttcattt ttgctgtctc cgcgccaata agcgcctgat actcttgtca 3264961 gtttgaacgc cttgatcatc cctgtagaag gaagatgcgg ccctcggcac aggtcaacga 3265021 attccccttg ctggtacagt gtgatatcct ccccgcgcgg aatatccttt aaaatctcaa 3265081 gcttgagccg ctcgtctttt tgtgcaaaca gctcttcagc ttcttcgtaa gaaacctcta 3265141 tacgtttgat ttcaaggttc tcatttatta tgtttttcat ttctttttcg atggcctcta 3265201 agtctcctga tgccaagctt ttccccagct tcatgtcata gtagaagccg tctaaaatca 3265261 caggccctac ccccaatgac acttcgccgt acagccgttt tactgcttgg gccagcacgt 3265321 gcgctgttgt gtggcgaagc acctgcaagc cttcttgtga atcgagtgtg acaatcgaaa 3265381 gctcagcatc ctcctccagc ttgaaactga gatcaacaag cttgccgttg acctgacctg 3265441 cggccgcctt cttttgcaga ctggaactga tcgaaccagc cgcttctttg attgtgatgc 3265501 ctttcggata ttcctggatc tgtccgtccg gaagctgaat gtgtacatgt ttgctcattt 3265561 tagaacactc cttattcatt gttgtatata aaaaaacaca cccgtcccgc agatagggac 3265621 gagtgtgtga ttaacccgtg gttccaccca agttcccgac aaatactatg ttgtcggctc 3265681 ggtgctgtaa cgcagcatag acggcattgg ttacttcagt tccccaatgc tgctccaagg 3265741 cggtaaatga tattcctaag ctgggaagct ctcacctttc cttccctctc tgaaaaccgt 3265801 aactatcatt catgtccttt tcatcgcatg tattcaattc ataaaaaaac acacccgtcc 3265861 cacagatagg gacgagtgtg tgattaaccc gtggttccac ccaagttccc gacaaatact 3265921 atgttgtcgg ctcggtgctg taacgcagca tagacggcat tggttacttc agttccccaa 3265981 tgctgctcca aggcggtaaa tgatattcct aagctgggaa gctctcacct ttccttccct 3266041 ctctgaaaac cgtaactatc attcatgtcc ttttcttcgc atgtattcaa ttcaaataaa 3266101 aaaacacacc catccctcta aaagggacga atgtgttgat catccgtggt tccacccaaa 3266161 ttcccgatca attacacatg atgatcggct taaagatgct gtaacgcagc atgacggtat 3266221 cagatacttg ttttccctga tacggctcaa aggcggtaag ctgctttccc tgcgttagga 3266281 agatctcagc tgtccttccc tctctggaaa ccgtaaaaag catctcgtgt ccttatcagt 3266341 gcctgttgtt tcaataattt tttatatctt actatatatt cccacaaagc gcaatcagtg 3266401 atttacattt tttctgacgc ggcagtcccg ttatgggcag ccagaaacag ccatacaagc 3266461 aatgcagcga ggctgtatgc cgctcccatc atcaaaaacg caaacccggc accagcatac 3266521 caagtggcgg acagatgaat gatcaccccg gttatcgcta cgccgaccaa ggctccgatt 3266581 tgccggtttg catttaacgc cgcaccggcg atattcgtat gtctttgccc ggcagcctgc 3266641 atgatcacag ttgtcatggc aggaactgta ataccggtac agaggttcat aacagacatc 3266701 aacaccgcca gctgccaata aggaaaatcc ggagaaatca gcacaaacaa cagcaatgca 3266761 atgatacagc tgaccgccat tgatacaaac ataagctgac cggcttcaaa ccgattcgcc 3266821 agacgggcaa acagcagatt gccgatcacg aagaccgcca tcatcggcag cagctccact 3266881 ccagccataa aggaacttgc ccctcctgct tcctgcaaaa aaaggctgag cataaacatg 3266941 ccgccaaaaa gggcgaaatt cagcaaaaac ccgataaatt gggcagctga gaagcggccg 3267001 tttttgtata aggacgccgg caggatgggt gtttttgcag aaatttcccg cagcaaaaac 3267061 agcacaaatg ccaaaaccgc tgcagtaaat gctacaagaa tcactggcga gcgccagccc 3267121 gctgaaggcc cctgtatcaa agcataggaa agaaacccga gagccatcat gccaagcaga 3267181 tgcccgatga tgttcacgcg gctgcttttc ccaggaacgc ggctgaggat tcggtaagct 3267241 gaaatgagcg cagcagcccc tattggcaca ttgatcagaa aaatactctg ccagcccgcc 3267301 aactgtacca gcacgccccc gataaaaggc ccaagggctg aagcggcgga aacaagcgcg 3267361 gcccacagtc caaacattct cgcccgcgcc cgctcatcaa ggtaagaggc agccaaaagg 3267421 ctgagtgagc ttggcataaa caaagctgcc ccaattccct gtatgagacg tccggcaatc 3267481 agcatctgcc catttataga tgcagcgcat agacaggagg ccataacaaa aacggctaga 3267541 cccaagatat agatcgtctt cgagccgaaa cggtcagcca aggctccgcc cgccagcaga 3267601 agcgacgcaa aagtaagaat gtacccgtcc acaacccacg ttacacctga aagtgacatt 3267661 gaaagagtgt ttttcatatc agccatcgcc acattcacaa cggtcacatc aagagttgcc 3267721 atgaggaaac caagtgcgag cacgatcagc acggatatgc ctgttgatga tgttgattct 3267781 tgtatagacc cgctattttt cattacaatt gccctttcac ttgcttgatt acccaatcat 3267841 ctattttttc aagatcatac aattccccga ctctgtccat aacatgctgc aaggattctt 3267901 ctctcataag attggaccat ttatcctcga tttccgccat gactgtctcc agcacacagt 3267961 gactttcacc ctcaaataca gattgcagca agcctttccc ctgatacatc gaacctctgc 3268021 cttcgaccgc ttgataaaca tcataaagcg taatgtcagc caaaggcttc gtcagggtaa 3268081 aaccgccctt cgtccctggt aaggattctg ccaaaccggc ttgaaccaat gttctcatca 3268141 gcttcttcaa gtaagacgga gacacgcgca atcgctggct tatagcctct gacgtcaaag 3268201 aagcctgtac cggcagccgt gacagtaaca gcagcacaga aaccgcctgc tccattcctg 3268261 atttcatttt catcctattc actcctgatt cattatggat aactattatc cataatgaat 3268321 ctcttagcag cttttgtcaa taaaaaaagc aaaagaaacg gatcatttct tttgcttggt 3268381 atggttaaca aatctgcttc agttcctcta tgtattgaag cgcttcgtca tattcttcat 3268441 ttgtatattt ttgcttgctt ttgatggtaa agactttttc tttcttttcc tcatcctcaa 3268501 gcccgtcaaa gtaaaggatc gtggaaacca gctctaaaaa ccgtgatgaa cggctgttta 3268561 cactgtcgat atagcctttc atatccggca tgtccagatc agcatggtct aaaaatgcgg 3268621 agcctgtctc agtcagcgaa taccggtatt gaaagtagcc gccctttttt tccttcacct 3268681 catgcagaaa tccaaggttg cacagctctt caatctggag cgtcagttcc tctgaatatg 3268741 gtccgtaaaa gtgaaaatca tatttctcat agaaaggaaa ctgcattttc ttggcgatat 3268801 aaatcatttt ctgcagcttc tttcgcccga tgatttctcc agaatccgag aacaccttca 3268861 tcagttttgc atgttctttc aacaaattcc cgacatctcc tttttccttc tttccaattt 3268921 ctatgtcagt cccagcagct gccggatttt cattttcgct tccggatgtt tagtgccgtc 3268981 acaaatcaag tcctttggat agtacagctt gtggtccgtc cgccgtttac ctgagatgga 3269041 ttccacaata gccgactgtc tggacagctc tttaatttgg ccgttttgcg tcaagagatg 3269101 gatcggcaga cgctcctctt cctctcctgg tcggtaaaaa tcgtatggca gatctgatga 3269161 agaatcaacg accaaataat agctcggatc gatccccgcc tctttgaaca atgaagtcag 3269221 ctcaaaataa gccgacattt cttcattcgg attgaattca acgtattgga aaagctggcg 3269281 gttaatgaat ctgcggcaca agtcggataa aatcgcgtct tcttcatcct cccaggcctg 3269341 gaagtaatac aaaataatag attcatccag ctttacataa tcctccagtg tcaattttcc 3269401 ttcaaaaata gaatagaaat gaaccggagc gtgagtgaag acatagcctt catcgtgcag 3269461 ctgcttcgcc ctgtgaagaa tcttcgttaa aatgacctct gcacttctag tcacaggatg 3269521 gaagtagacc tgccagtaca tttggtaacg gctcatgata tagtcttcga cagcgtgcat 3269581 tccgctttct ttaatgacga tctgatcctc gcgcggccgc atcacccgaa gaatccgctc 3269641 catatcaaaa tggccgtagc tgacgcccgt ataatatgcg tcgcgctgga ggtaatccat 3269701 gcggtctgcg tcaatctgac tcgaaatcag gctgaccact tgcttgtttt tatatgtttt 3269761 ggcaatgact tcagcaacat cctgagggaa acccgggctc acctttctga gcacctgatt 3269821 aacctccgtg tctcccaaaa tgatacctct tgtaaaatcc tcgtggtcaa ggtgaaagac 3269881 cttttcaaat gaatgcgaga acggcccgtg cccgaggtca tgaagcagcg ccgcggccaa 3269941 acagagttcg cgctcactgt catcccattc agggcggcct ttaaagacgt catcaaccat 3270001 tcttctgaca atttcataga caccgagaga atggttgaac cggctgtgct cagccccatg 3270061 gaacgtcaaa taggtcgttc cgagctgctt aattctgcgg agacgctgaa attcacgggt 3270121 tccgatcaaa tcccatatca gcttgtcccg aacatgaaca tagcggtgca ccggatcttt 3270181 aaacactttt tcttctgata attttccatt tggatacgcc atcgtcattc cctctttttt 3270241 ttagccgtgt ttctattata tcgactctat tctttgaaaa catccttgaa tttgcccggc 3270301 gatttgttcc atcttcatga aaaacacatc ttgtgaagca aaaaagcctg acctgagggc 3270361 cgaggctaag aaaaaatatg tttttacttt tttattttct tttttacttt gtcaatcagc 3270421 tcatcctctg tcggagctga cagcgggcga ttgttcacaa aagcaaatga ttttttccgt 3270481 ccgggcccgc aataagattg gcatcctacc tcaacctttg cgtccgggtc cacttctttc 3270541 aaacgcggca gcaatgtttt gatattagtg gcttggcaat catcacacac tcgaaattca 3270601 ttagccatga cgtacgcttc ccttcatttc tatgttcatc tatgtgaata acctaaaatc 3270661 acgtttcaaa aaaaatcaca tcacacttca ttttacaagg attcgactgt tcctgcaagc 3270721 cgctccatcc ttcgtatctc ctattctttc agccaatttg tataaatatt ttccaacctg 3270781 gacattctaa taccatgaaa agaaaaatgg gagttgagat aaatgacaaa acagcgacaa 3270841 gacgcttggt cagaggaaaa cgatctgctt ttagccgaaa cagtgcttcg gcatgtgagg 3270901 gagggcagca ctcagctgaa cgcctttgaa gaagtcggcg ataaattaaa ccggacatcc 3270961 gcagcctgcg gattcagatg gaacgcagtg gtccgccatc aatatgaaaa agcgcttcag 3271021 cttgcgaaga aacaacgaaa acagcggatg agagcgctcg gaaacgggca gcccgcgaaa 3271081 aaaagattat tatatcagcc tcctgccgtt gatcctgaaa tcattcaaga aaccgctgca 3271141 gaagagccgg ttaaaacgga aacaccatct gtcgaaaatg agcaaccttt aatgtctggc 3271201 gaacacatgc cttttgttga tgaaagcttt aaggaagagt tagctagtct atcacactta 3271261 ttgtctcctc aaacgcctgc agctgcgcct gagatgacga tgaatgatgt gatccgcttc 3271321 ctgcagaatt acgaaggcaa tcacgagcaa tcatcagcat taaaaatgga aaacgagcgt 3271381 ttaaagaaag aaaatcagga attgcaaaac aaaacagagc agctagaggc agaagttcaa 3271441 aagcttgaaa aagaccaaaa aacgatccaa gaagattatg aaaccttggt gaaaattatg 3271501 aacagagcca gaaagctagt tttatttgaa gaagatgaac atgcctctcc gtccttcaaa 3271561 atggaccgga acggcaattt agaaaaatta gcggaatgac atagaaaaat cccaaaacgg 3271621 gcagctgttt tgggattttc gccatgtgca aaatcccctt ttctattgag aaaagagaat 3271681 ttcctcattt tgcagccgga tcagctattc ttgtaaaatg aggccaagct tatgtgaatc 3271741 tattaagaca tgtgagctgc ctcggccgtt ttttgtttcc gaggcgcagc agaaatgacc 3271801 aaaagcccca gcatcataag cgcaatgccc agccacgagg aaggcgaaag catttcccct 3271861 atgaaaaaca cgccaagcaa tgaagccgtc agcggttcag ctaaagacag cgtgaccgcc 3271921 gccgaggccg gaaccccggt aagccctttc gcaaacaaaa agtatgcggc acatgttgca 3271981 attaacccga tgtaaaggct tgttcccagt cctctagggg tcaatatcca cgagatatct 3272041 aactgccata atagcggcgt cagcaagatg gcgctgatca tgaatacaac ggcggaggtc 3272101 gctcgcggag gctgggtttt catcatcgct ttactgatga gcgtatagcc tgcaaaagaa 3272161 gcacccgctc caagcgccat aagaacacca gccacatcaa tccgaacatt ggaactgtcg 3272221 gaaaacagaa gccagcaacc cgctaaagcc agcacagtcg caatccacca ggagtttcgc 3272281 gggcgtttct tcaatacagc ccattcgagg gtcccggcaa tgataggcgc actgccgatg 3272341 gcaatcacag ttcccactgc aattcccgtt tctttaaccg ctgtgaaaaa cagcggctgg 3272401 taacacgcca tacaaacagc ggctaaaaat acgagcggcc atgcccaatt tttcacgtga 3272461 agctcccggc tgatccaaac cgcaagcagc atggcgcttc ctcctattaa taacctgaac 3272521 gctccaaatg ccagcggtgt ggcgctttct ggagccaatg cctgaacggt tcccgtggtc 3272581 ccccagaaaa aagccgcaat caatacaaaa aggctgtaaa tattcccctt catctgcctc 3272641 tcccctttaa tatggatgct gatgtcattt tatcgttttt ctttttgtcg tggttatctg 3272701 tatgtaagaa ggacttatct gaaaataaga ttattgaggt aaaatgccgc ttgagataaa 3272761 aaatgcatgc cggcatatac agccggcatg cgaagaacgt tcacccaaat acctttgcat 3272821 tccgctcagc catccggacg aggtttttct caaattccat ttcctcatca atggacagtc 3272881 cagctgaata aagatgggtg cttaacgctt ttaattccgt caataaagcg aacattaagt 3272941 cttgtacgga gatgtctttt tgaagaagct cacttaagga cgccatcgtt tccggacgta 3273001 tttccggata gacgcctttt ttatcgtttt gtttgtcttt cagcgccgct tgatagaatc 3273061 gtctgatcaa gtcggccctt tcactgccgc ttttatctgc acagagataa atttgaacag 3273121 cgactccgcc gcgaacgcgt ctctgagaga tgccggcgaa ctttttgcca tttatactga 3273181 ggtcatagct gccgggacaa taagaccctt caatttcata ggcttcgatc tttgcgttgt 3273241 acggtctcag cattcgtctc atcagctcga ccatcgcttc atatcctttg tctatatcga 3273301 tgcctttctt ttcgtcctcg aatatgagag agatatttaa aacaccgtca tccaatacga 3273361 cggcaagacc gccggaattg cgtacgatca cacggtatcc ttcgctctcc agcaaggaga 3273421 taccatcctg caaaaacggg aggcgtgtat cctgtattcc aaggacaatt gtatcgtggt 3273481 gcacccatga gcgcgctgtc gccggcgaca cgccttttcc gacggacatg catagcgtat 3273541 catccattgc gaaggattgc ttcgcatcaa ataaagggcc gagactggat tggtcaatga 3273601 ctctccattt cggctgcatc agtaaatcaa tcggttggtt tgccatctat gtaaaaccct 3273661 ttcatgttag gcttattgaa cgaaaactat tatatcattt cagcagctgt gattgataat 3273721 tgcttttcag catcgtaata aaaatttctt tattttttgt attctccatg agaggagaat 3273781 gaatgtaaga cagcttgcgc tttaacgaga aattattaat atgcagaatt gaaatttcgc 3273841 ggtggatcaa atccttacgc agcacgcttc tggatagaac cgaaagtccc atgccgttaa 3273901 tcaccgcttc ctttacacct tgattgctgc tgatggtaaa cattgatttc ggccgaagtc 3273961 catttgaact gagtacatga tcgagatatt ctctcgtccc ggagcctttc tctcttgtca 3274021 cccacgcttc gttctgcaaa tcgctgatcg aaatctcttt ccgcccggcg agcggatgct 3274081 gatttggagc ggcaatgcac atttcatcct ccatgaacgg ttcaatttcc agctcattct 3274141 cgtttgtatg tccttcaatc agcccgatat cagcctgaag catccgcaca cgctcgctga 3274201 cctcctctgt attgccaatc atgacatcta gattcagctc tggatacagc ttttgcagct 3274261 gggccaatag cggcggaaga atatactcac cgattgtaaa gcttgcagct attttcaatt 3274321 cacccttcac atagtgatga tgcgcataga tttcagcctt ggcttgttcg tagagaaaca 3274381 ccatttgctt tgctctttga tataaaatgt ctcctgtcgg cgttgtcgta aagtgttttg 3274441 gcgacctgtt cagaagagcc gtttgaaatt ctttctcaag atttttgata tgcagactga 3274501 cgctgggctg ggagatcatc agcttttccg ccgcttttgt gaagtttttt tcttctacca 3274561 ccgctataaa cgttttcagc acgtcgtaat acaaaaaccc cacccctgtc attaatgaaa 3274621 tatatggtta tgattagttt tctttattgt actcatatca tccgtcttgg taaagaaggg 3274681 ctatacagaa gcgcaaaaaa ggcagccctc ggtcgagagc tgccattgtc ttcaatttta 3274741 ttacagtgct tgcgccgctg taattaatgc gagattgtaa acatcttcag cgttacatcc 3274801 tcttgaaagg tcgtttacag gcatatttaa accttgcagg attggtccta ccgcttcaaa 3274861 gttgcccaaa cgctgagcga ttttatagcc gatgtttcct gcttcaagac ttgggaatac 3274921 gaatacgtta gcgtcccctt tgatctcgga atccggcgct tttttctcag ctacagatgg 3274981 aacaaatgca gcatcaaatt ggaattcgcc gtcaagtgtc agttcaggcg ctttttcttt 3275041 cgcgattttc actgcatccg ctactttttc tgtttcatca gattttgctg agccttttgt 3275101 agagaagctg agcattgcca cgcgaggctc aatgtcgaac atttttgccg tattggcact 3275161 ttcgatcgca atctcggcaa gatcttggct gtcaggtgca atgttgatcg cgcaatctgc 3275221 gaatacgtat tgctcttctc cgcgagccat gatgaacacg cctgaagtct ttttcacgcc 3275281 ttcttttgtt ttgatgattt gaagagccgg gcggacagtg tcagcagttg agtgagcagc 3275341 tccgcttaca agtccgtctg caagtccttt atacaccagc attgtaccga agtagttctc 3275401 gtctaataat gctttacgag cctgttcttc agtcgctttg cctttgcggc gttctacgaa 3275461 tgcttgtaca aggtcttcca tgccttcata tgtatgagga tcataaatct taacgccgcc 3275521 cagcgtaagg ttcaattctt ttgcttttgc ttggatctca ttttcattgc cgatcacaat 3275581 cggattcagc actttgtttc ctgcaagctt gctgaccgct tctaaaatac gctcgtctaa 3275641 gccttcagga aatacaattt taacgtcttt tccagctact ttttcttgca ctgttgaaaa 3275701 taaatctgcc acaataaaac ctcctcaaaa agttacaaaa acgctttctt ttactagcat 3275761 actcttcttc caatcaaatt caaacagcca actttcatta tagcgctttc ataaaaaaat 3275821 cttatttttc taactaattt aagtgactca atcttccctt ataggttctt ctattttgat 3275881 ggagttatac ggaagggatg ttcaaggttt ctccacagta gaatcggata aactatggta 3275941 tagtgaaggc aatcatgaaa agataatggg agtgaagata aatgagtgaa cagcaaatga 3276001 cgaatgaagc ggcaaaaacg cttgacggct ggtatgcgct tcatgatttc cgcacaatgg 3276061 attgggcttc ctggaagctt ctgtccagtg atgagcgcca atctatcata catgaattca 3276121 ccgggttgct tgaaaaatgg ggcgtagccc aaaaagaagg aaaaggatcg caaactcttt 3276181 acagcatcgt cggccaaaaa gctgatttta tgctgatgat ccttcgtcct acaatggaag 3276241 aattaaatca aattgagctt gaattcaaca aatcaagact tgctgagttc accattccgg 3276301 catactccta cgtatcagtg gtagagctga gcaactactt ggcaagcggt gacggcgatc 3276361 cttatgaaaa tccgcatgtg cgcgctcgcc tttaccctga actgccggaa tctaaatatg 3276421 tatgcttcta tccaatggat aaaagaagat ctggcaacga caactggtat atgctttcaa 3276481 tggaagaacg cagaaacttg atgagaagcc acggtttaat cggccgcagc tatgcgggca 3276541 aagtcaaaca gatcatcacc ggctctgtcg gctttgacga ttacgagtgg ggcgttacat 3276601 tatttagcga tgatgtcctt caattcaaga agctagtgta cgaaatgcgt tttgacgaag 3276661 tcagcgctcg ctatggcgaa tttggttcat tctttgtcgg caatcacctt tcgcttgata 3276721 cacttcctca attcttatat gtataatatc cccgagctcg tttattgaga taaggactga 3276781 tcggccttct gctcaagttt gccgtacttt ttatatgcga atacactgag cacaaatccg 3276841 aggactgtga tggcggcgca aatcaatccg acagctgcat agccgtatgc cacatatacg 3276901 ggtcccatta aagcagaacc taatgtcacg gccagattcg aggcgagact gtaaaacacc 3276961 atgacttttc ctcgatgacg ctctgagcag tcactcaaaa tggtgctgag cagcgtcacc 3277021 gtcaaacttt gcattaatcc ccaaataaat aggctggcga ttaacagaaa catagacgcc 3277081 ggcgcatatg gtaaacacgc cagcagaacg ctgatgaccc ccagcgcaat caaaagggag 3277141 cgcatttttc cgatgcggtc ggctatcttt cctgtaatca cactcatgga aaacccgatt 3277201 ccataaatca tgataaataa gcccgcagcc gtgtttcctc cggtaaaaac gtcctgaaga 3277261 taggtgccta aaaaggaata cataccgtaa aaaccaatca tattacaaaa ggttattgtg 3277321 atataaacag gtacacgagg gactttcagc gcatcccgga atgttcctgc gggctcttct 3277381 atttcttcct tgccgctgtt tttatgttgg gcatggcggc gcatttcaag gagaatcagc 3277441 agaacaacta aaacacccat cagggcgaaa atccaaaacg tccatctcca atgcaggacg 3277501 ccgccgataa atgatccgag cggcactccg aaaatcagcg ccagcgacca gcttgaaacg 3277561 atcagtccca tcaccttgcc ccggtatgta taaggaacac gatcaccgac aactgcgtaa 3277621 gcggtcggaa caaacgctcc cgcagccaat cccgaaagcg cccggcctaa aaagaagaaa 3277681 aaaatatttt gagctaaagc gcatatcacc gttcctatga taaaaatcat aagcccggcc 3277741 aataagctca gttctctgga gtatttatcg cctaatggaa ccaaaagcgg cgcaccgata 3277801 aaaatcataa cgccgtaaat actgatagat aacgcaagga cgctgacatc tgagctgaag 3277861 gcttttgcta aatccggcag cagcggtgag atcacaagct cttcagatcc ggctgcaaat 3277921 acccccatcg ttaaagccag tgccaacaat aacggaaaat gatgttttgt tttgatgtca 3277981 ttgttttgat tgctgttcat tctttctcaa acacctcttc cataatcttc ttatcataaa 3278041 gttgtattat agtttagcat tgttttttct ctatttacaa ttcgaacgaa atatttataa 3278101 gttttattat tttcatttaa atcccattat atatttctat atttcattct aaaaatacat 3278161 gaggatgtaa cacgtaaaaa aagctctccg gcctcccgga gagctttttc tattgcgcct 3278221 ctgtctgctt tttttcaatc gtttcatgat ttatacgctt tttgatgctt agatgatagt 3278281 atgcataaca gaaaataatg atcggcacac cgcagtataa gccaattctt tgatccggaa 3278341 tgaaaataag gctgatcaac acgcagccat ataaacaaaa tccgagaatc gggactagcg 3278401 gataaagcgg cgttctgaac tccagatcat tcacatttcc gccttctgcc aggaaacgcc 3278461 tgcgaaagaa aaattgcgac gcacaaatgg acatccacgc gacaactgtc accatgcccg 3278521 agattgagat acaccataaa tacactgttt ctgcagccat gacacttgtc agcagcgaac 3278581 agcctgaaat gcctagcgta atcagcaggg cattcatcgg cacgcctttt tttgtcagtc 3278641 tggtgagaaa ggagggaccc atttgatttg atgaaagtga ccacatcata cgcgacgccg 3278701 catacaatcc cgaattagca acagataaaa tggccgttaa gatgacaaag ttcatgatat 3278761 ctgccgaaaa tgggatgccg atttgatcga gtactgctac aaacgggctt tcaatcaccc 3278821 ccgccgtttt gtacggaagg atggcaacca agacgaacat agcgagcaca aagaaaaaca 3278881 gcgtgcgcca aataacattt cgaatggact ttggcagtgt tttttccggg ctttcacttt 3278941 cccctgccgc aatgccgaca agctccgttc cctggaacga gaagtttacc atgaccagcg 3279001 taaacataac ggccagcacc ccattaggga aaagccctct atcagtcata aagttagaca 3279061 aaaagggtgt ctcctgtccg cctttaaagt caatcaagcc aaacacagcg gctccgccaa 3279121 tcacaataaa taatatgatc gccgccactt tgatgcttga aaaccaaaat tccatttccg 3279181 caaagcttct gacagagagc gcattaatca aaaagatgac gatgccgaac acgaggcacc 3279241 atatccagat cggaacggag ggcagccacc tttgcatcaa aatgcctgct gacgtcagct 3279301 ctaaccctac tgtattggcc cagctgaacc aatacagcca gccaatcata aagcctgtcg 3279361 actgtcccag aaatttagtg gcgtaggcct gaaacgatcc ggccaccggc atggcaacag 3279421 ccaattctcc taaacaaagc atgacgagat acattaaaaa tccgccgatg atatacgcgg 3279481 caatggcgcc gagcggtccc gcctggctaa tggtaaagcc agagcctaga aacagcccag 3279541 tgccaatcac ccctcccaaa gcaatcataa acaaatgcct gcttttcatg ctgcgctgca 3279601 attcattttt atgattctgc atcatccttc cccctttggt tcttttgccg tgatggtcat 3279661 ccggtagctt tgcaaaagat gaacggtggt ttgctgtatg aggagaggca atacatgaaa 3279721 tgtgtacggt ttatagactc gttctgtcca tttatggccg tcttttccgt acacgcccat 3279781 attaatggat ggaatattca gcttgcgtat gtctttgaac ggaatggtcc caatcatatt 3279841 ccacccaggg aagttcctga taaaagaatc aatttcgcca tcggtttcgt gcagtgataa 3279901 aaaactgccg tctgccaagt aggggaaaaa ctttttgaag acaaatgttt cgcctgtcga 3279961 ttcagcggtt ttgtcagccg cttctttaat cacatgctgc aaaagctgat ctcttgcgct 3280021 atcttctttc aaatagttat gcggcaggta aggaggtgcg taaaatagaa tgacttttgc 3280081 gccttgatcg gggtcaagct tttgaagctc ttcgattgcc tgaaagcatc tcatgcgaag 3280141 ttcaaggtgc tcgttggctt tgaatgtctg ctcgatacac tgctcgggat ctattccccg 3280201 gtttctcagc ttttctaagt attgctccag gctatacact tgaatgcccc atgataaatg 3280261 tttctttggc aggttggctc tttttacata ttcttcgtaa taatctgata atttttgttc 3280321 tgtctcccgg catgcttcct cagtgacttc aataagcaaa tccatcattt cttttgctgt 3280381 tctttcataa ataaaacaat tgaaatacaa gctggtgctg acagccgttt gcacattata 3280441 ggattccttg ttatcacgct gatacaaaca ggatgggggc agaaccaact ccccttcaac 3280501 cttttctgcc agatggatgt tattgtggag acggcttgtg atttcagatg aaatgaaatt 3280561 tgggtcaatc cctgccagtg tatcgccaac atggacttca cgcccgtaaa tgtaaaagca 3280621 aggcaacagt tttcccgcgg ctccggtata gatatatctt gtctgatcac catcgtaaag 3280681 cggggtaata aaatccgtat taatagcagc caaatagtga agctgttttt ctttttttag 3280741 ccggttcagc tctgaaatgc tggcgagaat gcccgaatgc tggctctcct catcgggatt 3280801 ggccataaac aatacatttc ccggcaacgt ctcaaggttc tccgaaaaat gcaggagatt 3280861 ggctaaatgc acggcgatgc cgctttgcat atcgacagat cctcttccga acatccactc 3280921 gcctgatttg gcatcccgct gaacatcctg atcgaactca tagcggctga aatactcggc 3280981 caatttctca caatcaaaag cgatatcctt taaagggccg aaatcttcaa ttccaactgt 3281041 atccagatgg gcatggtaaa tgactgtatt tcggctttct ccatgtcctt taataaacgc 3281101 aaaaatattt ttgcgtttgt atgggtcatt gggaatggcc tgttcccaca catgactggg 3281161 gttttcctga aaataaggat agctcgtgat cacttctttg atgaaatctg cttttgtccc 3281221 ttctccaacg gtgccgttca cgctgctgag gctgaccaga gatgctgtca gcgcctccac 3281281 tctttcagcc ggattcatgt gactgatttt tgtatactgc ataaattgtc ctcctgatca 3281341 aaaagttgaa atcgtgcgat ccgctaaaga atcgcacgat tttatttctc tcaaatcaaa 3281401 aagcttcgga cgttgttttg gcttgcatat gaagaattaa gtaatcggga ccgcctgctt 3281461 ttgagtctgt tcctgacata ttaaaaccgc cgaacggctg atagccgaca attgctccgg 3281521 tacatcctct gttaaaatat aggtttccga catggaaatc ctcgcgcgcc cgttcaatgt 3281581 gcgcacggtt tttcgtcaga agcgcacctg ttaatccgta ttccgtgtta ttggcaatct 3281641 ccagcatatg atcgaaatca cgcgctttgc aaatcgcaac aaccgggccg aaaatttctt 3281701 cctgcatcaa gcgggcgttt tcatcaacat ctgcaaagat cgtcggctga ataaagtagc 3281761 cttttgaatc atcgccttct ccgccggcca atagcttgcc ttcagatttg ccgatttcaa 3281821 tgtatttcat cactttgttg taggatgctt catgaatcac gggacccata tacgtatcag 3281881 gatcttctgg attgccgaca gtcagcgttt tggtcagcgc cacagctttt tccaccactt 3281941 catcatacac atcctgatga atgaccgcgc gggagcccgc agaacacttc tgtcctgaat 3282001 atccaaatgc tgaatacacg atagaggatg cagcaaggtc aagatcagcg tccttgtcga 3282061 caagcactgt gtcttttccg cccatttctg caattacccg tttgagccat ttttggcccg 3282121 gctgcacttt ggcagctcgc tcataaatcc ggcagccgac tgcacgggaa cctgtaaatg 3282181 agacaaaccg tgtcttcgga tgctcaacta agaaatcacc gatctccgca ccatctcccg 3282241 gaatgtaatt cagaacgccg tttggcagac ccgcttcctc catgacctcg acaaattttg 3282301 ctgccactac cggggctgcg tcagccggtt ttaagagaat cgtatttcct gtcacaatcg 3282361 ctgccaccgc tgttcccgcc ataatcgcga gcgggaagtt aaatggagaa atgacgatgc 3282421 cgacgccaag cgcttcgtaa tgatattgat tgacctcgcc agcacggctc ttcaccggag 3282481 ccccttcctt gagctttaac atttggcgcg cgtagaactc taaaaagtct atcgcttcag 3282541 ccgtgtccgc atctgcttcc ttccacggtt ttcctgcttc cttcacaaga tagcttgaaa 3282601 attcatgctt tcttctgcgc aaaatagccg ctgccttaaa gagaatattt gcgcggtgct 3282661 ccggtctttg ttttttccag gaatcaaatg cctgcaatgc ggcttgcatc gctttttcag 3282721 caagctcttg atccgctgta gacgcgtacc caatgatctc ttctttattt gccgggttaa 3282781 tagaaatgat tttgcggtcc gtttcaattt tttctccatt tatgacaagc ggataatgct 3282841 tgccgagctg agtgtttaca aaggccaatg actccccaaa tgcagtttta ttctttgctt 3282901 ccgtaaaatc ggtaaatggt tcgtgcgcgt atgtgactgt catatgtagt ccccctcgtg 3282961 ttatgaaata tatcttcgca tatgaataaa aatgcaagaa tcatgccatt ttcttgtctt 3283021 ttgctgaaaa aacttgttga atcgaacaga aatttgtcta acaggtgatc acctttctct 3283081 ttttccgatc ttgaacgcaa atttattttg cgttttttgc tctttacgca aaaaacaaat 3283141 gcaaaattat tttgcggagg cttctcaaat tagacccatc cgcggaaacg cgatgcttct 3283201 gccgattttc tgatgcccgt catgtaagcc gccaaacgca tatccacttt atgtgttgcc 3283261 gctgtttgat aaattgtttc gaacgagctg accatgacgc ttctcagttt ttctgcaacc 3283321 tcttcttccg accaataata tccttggttg ttttgcaccc attcaaaata agaaaccgtg 3283381 acgccgccgg cactcgctag gatatccggc acaagcagca cgcctctttc attcaggatc 3283441 ttagtggcat caatggttgt cgggccgttc gccgcttcaa cgacgattga cgcctgaatg 3283501 ttatgtgcgt ttttggctgt gatttgattg gagatcgcgg caggcactaa aatatcgcaa 3283561 tccttttcaa gcagctcctc atttgtgatg acgtcagtaa ataaattggt gaccatacca 3283621 aagctgtccc gtttatcgag caaataaggg atatcaaggc cgtctgggtt gtagagcccg 3283681 ccattggcat cagaaatccc gatcaccttc gcgcccgcat cgtgcatgaa tttggccagg 3283741 aagctacccg cgtttccaaa gccctgtatg atgatgcgcg cgttttgcag cttgatccct 3283801 tttttcttca ccgcctcttc aatacaaatc gtgacgccct gtgccgtcgc tgtttcccgt 3283861 ccttgcgatc ctcccaaaac aagcggttta cctgtaataa agcccggaga atcgaattcc 3283921 cgcagccggc tgtactcatc catcatccac gccataatct gcgaattggt gtacacatcg 3283981 ggagctggaa tatcctttgt cggaccgacg atctggctga tggcacggac ataccccctg 3284041 ctcagccttt ccagttctcc aaatgacatt gtccgcggat cacaaataat accgcccttc 3284101 ccgccgccgt aaggaagatt ggcaatcccg catttgagcg tcatccaaat ggataatgcc 3284161 tttacttcct cttcattaac ttctggatgg aagcgaacgc ccccctttgt cggaccgaca 3284221 gcatcattgt gctgtgaccg gtagcctgtg aacactttga cgctcccatt gtccattttg 3284281 accggaatgc ggacagtgag cattctctgc ggctctttca tgagttcata catatctccc 3284341 ggataaccca gcttccgaag ggcttcctta atgattgttt gggtagacag aaataagtta 3284401 agagcttctt tttcttcatc tttcgagact tgctttgctg acatcttttt cacctcattg 3284461 tttttttggc cggctgtaat gtaagcgctt taaaaaatca gcccgccaat tcctttcttc 3284521 attggattca cccttatcat catgcaagat ccgtaccagc ttttgaatcc acaaaaaaag 3284581 agactgaaaa catctcagtc tctgactaca aatctatcga ttaacgggga tcaatcacca 3284641 gctgcgtttc agcataaaaa ctgccgattc ccaaaccgtt tactacatcg cctttaatcg 3284701 tgtaagtgcc tgcgcgagga agagttttac gcaccatgac aaggtcaaat tcggatgcgc 3284761 ctaacaaatc aagcgtaagc gggagtctga ctgtttttcc atcgtttaaa atctgtgttt 3284821 ctttcagtgt tcttccattc actgaatctc ttgtcgtagc atgaaacccg tcaggaaatt 3284881 gaaattctac cgctccaaga gaaagcaccg catttggttt atatgtcact tcaatatcag 3284941 aaatggtcca ctctttcgtg ctgttaactg tttttgcctc gattgatgca gactgtgcat 3285001 gagcttggcc cgaaggaagt aagattgata gtaaaacagc tgaactgatg aataatgaag 3285061 atacgaatga agttcttttt agcatgacat ttccccctaa ttgattgttg aaatttggcc 3285121 agagcgtcct ctgcagaaaa agcgcttttt cataattcgc gaattaccag ttctttttct 3285181 taaaaattaa tctatcatca ttttccatgg aagtaaatgt tttttaagga atattaacac 3285241 ttggaattca atgagaattc cttcctgttt atacaaggtt caaatggacg atttccctct 3285301 ctttttctag taacatctgc ctgacatttt atatctttta tcctatttta aaaaagggca 3285361 aaaaaagtcg aagatgcctc tgctcttcga ttgatcacgt tcctattttt atctgaattc 3285421 agtgttccag ttaaaaccga tcgtctcatc atcccacgga attctttttt catcaggctg 3285481 atccgggtta tacgacatgg tggtaaaata gataattgtc agcggcgtct ctcccagcac 3285541 tctatatccg tgagccaccc cttttgggat taataacagc atcgggttgt cttcgcccat 3285601 ataatagacg tccgtttctc cttttgtctt tgaatcctct cgaagatcgt ataggacaac 3285661 ctgagcgtgg ccggttggga agaaccagag atcatcctgc ttctcatgat aatgaaatgc 3285721 cttaatcaca cccggatagc ttttcgacca agaggcctgc ccaaaatgct caaggagatt 3285781 ctcatcgtcc cggaccagct cagcaaaaaa gcctctgtca tcgctatgct tcatcaattt 3285841 tttcaccttg actccatcaa tcacacgcac tgctcctttc ctgcaaatac tctcgtaacg 3285901 cttcccgcca gtggcggggg cggatgccgg cttcttcaat agcccgatgg ctcagcacag 3285961 agtatgccgg acggggcgtt ttgttcccgt attcctctgt cgttacagac aaaatggctg 3286021 tttccagccc gctttcttcc ataattgccg tcgcaaactc ataccagctg catatgcctg 3286081 aattgctgac atgatagatg cccggcggat ggctgaacag cttgatgacc gcttctgcta 3286141 aatccttcgt ataagtcggc gaaccaattt gatcgctgac aacccgaagc tcttgtttcg 3286201 tttcagcaag tttcagcatg gtttcaacga aattactgcc gccatgtccg tacacccacg 3286261 atgtcctgat gatcgtgctg tcttttgtcg ttaatcgtat cagttcttct ccgagccttt 3286321 tgcttttgcc ataaatggtt ttcggatcga ggggatcgtc ttccctatat ggctgggttc 3286381 ctttcccatt gaatacatag tccgtgctga tatgaacata ttgagctccg atgcgggttg 3286441 actcaagcgc tgtataataa gcgccgattc cgttaatcaa gtacgcttta tcaagctctt 3286501 tctcgcattg atcaaccgac gtaaacgcgg cgctattgac cacgatatcc ggctgataat 3286561 ggccaaacga atgccgtact gagcgctggt cagcaatgtt catcatcttc tttgttaacg 3286621 caatgacctc atatccggct tgcttcagct ggcggcatag ttccaagcca agctgtcctc 3286681 ccgccccagt caccaatacc tttgtcaatc agatcacctt ctcatcggtc attgtctgta 3286741 taccactgaa tcgtacgcgc aatgccttct tcaaacgtca cttcctgccg ccagcccagt 3286801 tcgtttttca gctttgatgc attgatcgca tagcgccggt catgcccttt tcggtcttcc 3286861 acgtgggcga acaattcctc acagcccaga tgcttcaaaa tgacactcgc cagctcttta 3286921 ttcgtgcgtt catttccgcc gccgatgtta tacacctcgc cgtcggtccc tttttctaaa 3286981 atcagcttga tcgcgcggca atgatcctcc gcaaacagcc agtctcggat ctggagtcca 3287041 tcgccataca gcggaacagg caggccctgc ttcgcatgac ggataatcgt cggaatcatt 3287101 ttttcgctgt gctgataagg tccgtaattg ttgctgcatc gtgtaatgat ggccggaagc 3287161 ttgtgggttt tcacataaga caacacgagc aaatcagagc ttgctttgct ggctgagtat 3287221 gggttattag gagaaagcgg cgtcgtttct gtaaacgcgg gatcatccgc ttttaaatcc 3287281 ccgtatacct catctgttga aatatgaatc agcttcttgg cttttccttt caagaccgct 3287341 tccgccaatc ggtatgtccc catgacattt gtggtgataa acggctccgc ttgggaaatg 3287401 cttctgtcca catgcgattc tgctgcgaag tgaatgacgc catcgtaggt ctcgtcaaaa 3287461 gcgcggtcga tatcctcctg aacgctgatg tcccctttta caaagcgaaa acggctgttt 3287521 tgctttaatt tttccatttc ctccgggtgg ctggcgtacg tcagtttatc taaaacggta 3287581 atgcgcgcat ccgtttccct cagcatgagc tttgtaaacg tgagcccgat gaagccggcc 3287641 ccgcctgtaa ttaaatatga ttttgccatc acttttcgtc ctgtcctttc cgtaaagcct 3287701 ggtgtacaag ctgggaagcg agataaagcg attcgtgagt tccggcatct acccaccagc 3287761 ctgataacac atcatacgta agctggctgt tttcgatgta tagattattc acatcggtga 3287821 tttccagctc gccgcgcttt gatggtgata tttgttcaat atatgaaaac acctctgcat 3287881 catacatata aatgccggta acacaaaggt tggtcggtgg ctgttcgggc ttttcgatga 3287941 tggaacgaat ccgcttgttt ttctcatcaa tctcagcaat cccgaaacgt tccgggtcat 3288001 caacttcttt cagaagcact tttgctcctt tcccctgctg ttcaaagcgt tctgtataag 3288061 gctttaatga atcttcaaat atattatcac ctaataataa aatgaaagac tcttttttcg 3288121 taaagcgctt tgcataagac agcccatccg aaatgcccga tgctgccggc tgtacttgat 3288181 aagtgatagt aacgccaagc tcttccccgt tcccaagcag tttgtaaaat tgcggcatat 3288241 gctccttttg gctgatgagt aaaatgtctt ttattccggc ttcctgcagc ttcataatcg 3288301 accagtatat catcggatac gggcctacag gaagcaaatg cttgttgacg gctttcgtta 3288361 agggcataag gcgtgagccg tttcctccgg ctaaaataac acctttcaca ttaacacttc 3288421 cttacatgca tttttatatc tcttgttcat ataaatcttg aagaatagct gttacccgta 3288481 taatgccttt gccatccacg agcggccttc ctcccttgtg caaagaaagg cgaagaggat 3288541 agctgctcat aatgcgtgac atctgataga tgagtgtttc atccggtaca agctcaccca 3288601 atccaagatc aagagcggcg ccttggtcag caaatgtttt ggctgtagcc gtttgatgct 3288661 caacctgaga aagaacaagg cacggcacgc cgatgcaaat ggcttcatat agagagatgc 3288721 cgccagcgac aatggctgcg tccgcttgtt tcatcaaacc tgccatatca tttgtctgtt 3288781 cgatcatctt gtactgcggc ttcttttcga tccgccttcg gactgcctct tgatgcggtg 3288841 aagcgctccc catcacaaac atcatgtttt tgtcttttat gtcggggact tgatcagcgg 3288901 cagccagcac tttaaaaata agctgcttcg gatcacttcc tcctaatgca acaaggatat 3288961 tgcggcagtc tttcttaagt gtgtaatcct ctcttgcggc ctgaaaggcg gggtgaagaa 3289021 taagatagtc cggaccttca tagatgcgtg tgtttccctg aacgtacacc ctgcttctga 3289081 tgtcaccgta aattccgtta atgactgcgt cactatattg aatcgattta ccgtttttct 3289141 cttcaaaaag aacaattttc gcatctgtct ccgtctttat tttctttaac agctctgcag 3289201 gcgcgcctag aatatcaaac aaaagcaaat caagcttctt gctttttatt tcccggagaa 3289261 taaattcgtg ctgctgcagc tccggcttta cgatgacctg ccaatgctct tcatgaagaa 3289321 acgcttcaga atcctgattc gtataaaacg taatcaagca tcgctgtttg agcccctccg 3289381 caagcctctt catccggaca acatggccca ttcccttttc atagccgccg tctgcgaaga 3289441 tcccaacatg catggctagt cagcctctcg ttcggttgcc gcatcggggt tccggttcag 3289501 aagggtgata agctctgagg cggatacatc ggggcgctcg cctgcttttt gatagagggc 3289561 ctttatcgat tcatagtctt cctttgtatc aatggtcagc cgatattgag gggcgcgaaa 3289621 tcgttccggc gcctctaaaa actgaacacg ataaagagct ggatgattcc ttatatataa 3289681 cgtgacatgc tcctgatatt gatcctccaa agcctgaata cggctgatgt caattaacag 3289741 gttggcgttg accacttcgc cgcaaatccc taatggggca ttcaggatat acgtataatc 3289801 cgagccttga tcaaaatgcg cctgaatcat tacatcgagc agctcaggat cgacaaacgg 3289861 attatcacct gttaaccgga tgatgactga cggtttaaca gcttctatga ccttcacaaa 3289921 cctatcgagg acacgttctt cgctcccgcg gaaaacacga aagccttgtt tgatacagtg 3289981 cgcctctaat atgtcgtcag tttctttgtc agacgtggcg atgacaagat tatcccgatc 3290041 cttttggtaa aacgcgcttt gccggacacg gtgaacgaga atatcaagta aacgattcga 3290101 tccgagcggc cgaagcactt ttcccggaag ccttgttgaa cccattcttg cttgaatgat 3290161 aaagagaata tcattcatga aacgggctgt ccttcagtaa aatgtcatcc cagacaatgc 3290221 ctgtgtcggc tggaatgtct cttacagccc gaacaccgct ggtcagcagt tcaaaaaatc 3290281 tcgggtgcag cccctgcggc ttttgtccgg gccgaagcac tgcgatattg tcttcactaa 3290341 aggcttcacc tttttgaatc ggagctgttg taaaaatgcc tctgtatgca aagtttctga 3290401 tttctccttc gatggcggtc gttgttttgt atgaactgcc aagcagtttt tcagagaccg 3290461 gctttgtgat cccctgtttc agctcagctt ccgttttcct gatgccatcg accatttctt 3290521 tcaattcatc cggatttaat gcaaacgagt ggtcagcacc cggcagattt ttatcgatcg 3290581 taaaatgctt ttctatcagt tttgctccga gccgaaccgc ggcacacggc gcttctgtcg 3290641 gatgctcgct atgatcggag aagccgatta ccgcctcagg aaaagcggcg gcaagcatcg 3290701 gaatgacgct gaggttgctg tactccggcg gtgctgggta tttcgccaca caatgcatta 3290761 tggcaatttg attgtttccc tctgccctga tggtgcgcca agcttcgtga acatcagaga 3290821 tttcagctcc ggctgtcgag aaaatcatcg gcctgttcag ccgggcgaca tatttaagca 3290881 gcgggagatg gttaatttca taggatgcga ttttaaaagc gctcggcgag gtagactgaa 3290941 gcagatcagc tgacccctcg tcacataccg tacttaaaaa gatcacctgc ttttcgcggc 3291001 agtaatccaa tagcggtaaa atccactcag caggcatttc catagattga accaaagaaa 3291061 aaatagagac gtccttgccc gctgccgtct tgtacaaacc aggatctttc tggtacatcc 3291121 tatcagcttg gaacatttga aatttcacgg catccgctcc cgcttccgcc gcggcgtcta 3291181 tcagcgcaaa agcctgatca agcttcccgt catgattaat ccccgcctca gcaataataa 3291241 aaacaggagc gtctttgcct acagttttat tcgcgatctg aaacgctgcc attatttcgc 3291301 ctccttgccc ggccaaatat gataatagta atacgattgt tcagcggtga agcccattcg 3291361 ttcataaagg cggatcgccc ttacattgtg aagctgcgtc cccgctgtta ccgttctatg 3291421 cttctgggtc tccggttgtt ctatgagatt cgccaataaa tgaaacgcaa tacgtttccc 3291481 ttcaaatccc ggctttacag ccatcaaatc gagaatgcac tcatcatctc ttgataagcc 3291541 ctgaagatag ccgatgacct cgccattgtg tttagcgaca atattgaccg ccgcccttcc 3291601 attcagattg tttcgtgtcc actcctgaaa tatttcgttt gctgcatcgc ggctgagatg 3291661 aggatcctga aaatatctgc tttttgtaaa cgagtctcgg gccagctcac atatcgcttc 3291721 tgtgtctccg ggctcaggcg ggcccagttc aaaaaatggc ggtgttttgt cataaaaaga 3291781 cggaggcatc gccagcttca gcaaactccc gacaaagtaa gaggatggct gctgttgtat 3291841 cacatgcgcg gctccgatat cttcagccgg aacacggaca aagataaaat ccgtttcatc 3291901 catttggcgt acagtataaa aagcttcaaa cagcctcttt agctgcccgg tactatttgc 3291961 cgcaagaagt ttgacgttca tgactttctt ctgaagcacc ttgctttccc acaaagaatc 3292021 ttcgtaaagc aatacgcctt ggagcctgct gttttcaaaa aggccgaggg aaaattgata 3292081 cggaacatcc aatgtaagct ttctgctttg gagaaattcc tcaattgcct ctttggagac 3292141 attttctttt accgtataca cttaatcagc cccttttacg atatcccgca cagcttcaat 3292201 gacatcatct acatcatcgt cagacattga tggatagagc gggagagaaa gggttcgttt 3292261 atagtaattc atggcattcg gaaagtccgc ttccttatat ccaaattgct tttgataata 3292321 cggatgaatg tgtactggaa taaaatgaac gctagtgccg atattgtatt catcctttaa 3292381 agccgtaatc atttcgctgc gcgtaacccc ggcctttttt tcatcaactt gcagaacata 3292441 tagatgccag gcgtgcctgc cgtcatcatg gacaaacggc gtgatcagcc caggaatctg 3292501 ctgaaaagcg gtttgatagc ggccggcaat ctcttctctc cgtttctgca tatcatccag 3292561 ccgtttcagc tgatgaagtc cgagggccgc ctgcaaatca aacatattca tcttatagcc 3292621 gggcgattcg acttcatagt accagctgcc atttgaagaa taacggttcc atgcggcttt 3292681 actcatgccg tgaaggctta gcacccgtat cttatcggca agctcctcat catcagtcgt 3292741 cagcatgccg ccttcccctg tcgcgaggtt tttggtggcg taaaagctga atgccgttgc 3292801 atccccgata gaaccgatca ttctttgctt ataagtcgta tataccgcat gtgccgcatc 3292861 ctccagcacg aataaaccat gattttgggc aacagccaat attgcatcca tatcgcagga 3292921 ctgcccgcca aagtggacgg gcacaactgc tttcgttcgc ggtgtgacgg ccgcctcaag 3292981 ctttaccggg tcaatattga gcgtgttttc gtcaatatcc gcaaacacag gcgtcgctcc 3293041 cgtatgaata atcgtattgg cggtcgagct gaacgtaagc ggagaggtaa tgacctcgtc 3293101 cccgggccca atcccttttg ctttcaaagc caaaaataaa gctgcggtac atgaattcac 3293161 cgccacggcg tgcttcgccc cgacaaacgc ggcaaactct ttttcaaact gctgaacctt 3293221 cgggccttta gagagccatc ccgattcaag cgtttctgta acctcctgaa tttcttcctt 3293281 accgattaac ggcaatgagt aagggagaaa atgatttctc ttttgcacca tttctttgcg 3293341 ctcctatcat tttattcagt atcttcccgc ctgtaatcaa cccctgtttt ggctttcagt 3293401 tccgcaaata aagcatttgt tgattctgcc accggataat tagccgctat gaatgccagg 3293461 cgcgcctctt ctgctttttg atgcacgtcg ggacttcgaa gaacctcaac caaggtgtgc 3293521 gccagttcat ccggctggtc aaacataaaa tcgccaagag actcataata cggatacgag 3293581 cgatttccgg acgattttcc tatcagcaca ggcttttgaa acagcatggc ttcaagaccg 3293641 actgtcgagg tttgcgtcac tgcggcatca acatacggca gcaaatcata aagctccagc 3293701 tcctttttga tgactctgca tgcttgatgt tttttcgccg cctcgtgata cagatcaagc 3293761 ttgttttttc cgatttccca cgggtggggt ttgataatga tttgcagctg cttctgatca 3293821 gaaagcccct gcagcacacc ggaataaaag tcttctgaaa agggctgagt ggcaatgagc 3293881 acaatttttt tagtcggctg aaaagcaagt tttcgataga atatggacat atccataggc 3293941 gttctgttaa aaatctgatc gaagcgggga tgtcccgtta cgagaatctg ctcgggttta 3294001 cagccttttc gtatgaacca ctctgcttca tacgcaccaa aaacagcttg ataggttgta 3294061 aaaacaggaa tgaaggcttc atctcccatc aatgcgccat gctgaagaca aatgctgacg 3294121 gccccttttc tttgacacat gagagcgagc accctgctgt aaatgtcttc tgccgttccg 3294181 acaataacag ctgaaatctt ttcctgttca aacagcgcat caactgtatc aatggcctct 3294241 ataaataaag gaatatcttt gaaaagccgg tcgcgaaacg cttgatcacc aaatgccggg 3294301 tgatcatcat aaggggcgag aagcgaacag gctgtttcga gatactgctt cgaatcgcct 3294361 ttttggcatg aatccgcaat ctcccgcttg ctaattacag gcagatcaca ataatgcggc 3294421 aaactccatc tggccaaaac agccgttttt tcaggatcaa attgatagta attttcgttt 3294481 gaaaaacgca ggtaatcaaa gtgcaaaatg actttccctt taacaggttc gtcatttgtt 3294541 ttaacgatgt tttggattct ttcttcaaaa aacggctgaa tctgtccctc atcgatatgc 3294601 tgatccaccg atccgaataa ttccggttct tcttccatca tcaccctcag ttcagggctg 3294661 atgtattgat aaaaattact gataagccca agcggaatcc ctttgtagcg aagtttgtca 3294721 aaaagctcca cgtacttccg gtacagcacc caataattgc ttaaataggc cgacaagctc 3294781 tcaccccatt ccaagctttt ttaatgattc acgcagctct cggcaatttc gctgcggagg 3294841 aaggttcctg acaaattcat ttttttctaa ttcaaacagc tgaaagtgaa tcgattggtc 3294901 ggtaatataa ttcaggtcca gctcctcatc cagtgggtaa aacggataaa aatgattgac 3294961 tctccaaaag aaccgggcat ctcctatacg gtaaaacgcc gggctttcat cccaatagga 3295021 gccaaacttc tcctttacct tctcaagcac cgaatacctg tgcatcaccg agcaatgatc 3295081 aattgcgcac ggcgcgttcc atgtcacttg agcggcaggc ctgacagttt cttttacaat 3295141 gtcacgattc tcgtttaaat gataggtttt ggaggctgag taaatcacag ccttttcagg 3295201 atgggtatcg agctcccgca ccattttcag gaggcggtcc ggcatataga tgttgtcatc 3295261 cgtcgcatag gtgatatatt caccctccgc catctcaatc gcctgattga tcagtgccgc 3295321 gtatctcgtt ttttctgttc tttccttcac tccagatata tcgctttgat aaaaacgcac 3295381 tcggttatca ttcaaaaaag gacggattac attcagcgtc tcttcattgg agttgtcatc 3295441 cataataaac aattcaaaat ctgaaaacgt ttgtgagagt atgctagaaa tggactttgc 3295501 cacataatcg cttttgttat agctcgtcat aatgactgat actttaggca aatcctacac 3295561 ctccttcttg gaacttcaca cctgaaacta tcgttatctt atgttgctta tgctcaagtt 3295621 gcgctaggga tacaaaccaa tatgcgaaaa gtttgtgtat gtttctgaaa aacagcggct 3295681 gcccagagcg aaatctgatc ggtccgctgt tctttttcag cataatccaa gcatcagcct 3295741 cataaggtga aagagataaa aatcgcacca gcgactaaga tcgttttcca tcggaggtga 3295801 gtcatcgcgg agcgttcacc tatacatcca gaacatgttt tgaatggttt tcataaaaag 3295861 gaggaacgat atgaaaccga aaaaaaatca atatcagcaa atgcaggcat ttgataatat 3295921 gcaggggtat cagcctcagt ttggcgccaa cccgtacccg cagcaaggcc aaggctcaca 3295981 aatgcagaca atggggatgc agccaatgat gccaatgcag cagggacagc aaggacaaca 3296041 aggacagcag ggatttggat tcccgggcca gcagcagggc ggcggttttc aaattccatc 3296101 ggggcctaca ccgtcaggac cgggccaaag cgttcccggc atgctgcctg ttgaggaatc 3296161 ttacatcgag aatattttgc gcctgaatcg gggaaaaacg gccaccattt atatgacatt 3296221 tgaaaacagc aaggaatggg gctcgaagat ttttcgcggc gtcatcgaag ctgcgggccg 3296281 ggatcacatt attatcagcg acccgaaatc aggaacacgc tacctgctcc tgacaatcta 3296341 cctcgattac attacatttg atgaagaaat tgcttatacg tatccatatt ccatggcgtc 3296401 ctattcgcca agataagaaa aaagccaatc actcatatga tgaggattgg cttttttgtt 3296461 tatagatatt tgacggctgc gacaacgatc ataatccaag aaataataaa cgccacaccg 3296521 ccgagcgggg tgatcgctcc aagaatggag atttgcgtca cacttagaat atataagctt 3296581 ccggaaaaca gcacaattcc cgcaaacatc agccagccgg ctgtcgtgac actgcctatg 3296641 ccggataatt tatcagccag aaacgcgaca acgaataacc caagggcgtg atacatatga 3296701 tactgcacgc ctgtgtgcca aacctgaaga tacttatcag gtattttccc ttctaatccg 3296761 tgagcgccga atgctccgag tcccacggca agcagggcgt taatggcccc taatatgata 3296821 aaaactttca tctatctctc ccgccttttc gttaaactca tatcatttat cttatcgcac 3296881 ctgcaccaaa attcaatgtt tgttctccgt tgacacgaga ttgtcggatt ttctcctgcg 3296941 ccaaagctgg aactggtcag ctgctattgc agcaagcgtc cctaatacga gcccgttgct 3297001 taatagagaa ataaataccg gatgcaatcc ctttaacgca gtttcaggaa caaacatgat 3297061 accgacccct gtcagcagtg agataccgat gatagacctc accctttttg attcttcttt 3297121 ctcatatgaa tcaaattcgg caaaggccag accgcccatt gcggagaaca caacaaaatt 3297181 caccgcaaat ccaacgggtg acggcaggct cgcaaacgta ttcataaaaa acgggatcac 3297241 gctgatcacg ataaccagaa tactgccgag cataaacggt tttttagaag gcatcttggt 3297301 cgtttcaata aaacctgcgg ctcccgaaat cggaacaggc gcaatagctc ccgtcaaacc 3297361 gctaagcaga tggctgaatg aagctgcaaa accggcatgg cgttcatgat gctttccatc 3297421 aggctgtttg ctgaattttt tcatggcgat gtccacgacc ttcatgctcg ccagcatatt 3297481 cacgatcagc aagatggtaa taaaaataga agtgatgatc aggccgctgt taaataacgg 3297541 ggtcccaaaa ggaaacaggg aaggcagctg aaacagccgg tccggcattt caatcggctt 3297601 tgcggctccg gcagccgcaa acagcaccca cccgccgaac aaggctaata aaatagaata 3297661 ttgcttaaaa aacatgatgt tcgaatttgt cattataaaa gcggcagcga tcacaacaag 3297721 cgccaggcca aatacaagac cgtccacccc gtcctgtcga taaccgattc cgagaattcc 3297781 ttttataatg ggctgactca gctgcatgac aagaagcaat aaatagacgc ccgttacaac 3297841 cggagtaaac aattttgcaa gtctgtcaat gaccttgaaa acacttaaca aaaagaaaca 3297901 tacagcgctt acaagaagag ctccctgcaa accccgcagt gtgtctccat atgtcgcaaa 3297961 cacagttccc gtcagccctg cgtaaatcgt atacactccc caccacaagc cggctgggct 3298021 ttcattgatc ggcagtctgt ggcctttcaa acactgaatg acggcggcaa ttcccagtac 3298081 aaaaaaagtg ctttgaatca atcttgcaga atctgagtga tccagatgaa acgactgggc 3298141 aaccgccacc ggaacaacaa tcgccgcagc aataataaac gctgtccatt gcagcgcgcc 3298201 aagaaccaat ttcacgtaag ctcaacctct ctctttaaaa atcaaataaa gactctccgt 3298261 ttccatcctc ttcctgcttc tctttttctt gctttcgata tttgtttaat cccgcgctcc 3298321 ccatcatttt ttccatcatc agctggtctg tcgatggcgg cgcggcggga cttggcgtaa 3298381 cgctcggctg tatgcggggc gcgctcgcgt tctccggctg atcaagcacg acatcacaca 3298441 gagaacggac aaccgctaca taacgcttca gctcctcatc ccgttcagcc gtttttgctt 3298501 tttttagctc ttcttccatc ttttgaatca aagcagatat atgaatgttc atgaagcacc 3298561 ctccaaaaaa ataaatgttg tcttcctgca ttttatcaaa ttcctgctga aaacgcagat 3298621 atgagtttgt tattttttct gacaaacctt gcgcgattga caagcagaag agatttttca 3298681 cataataaat caccatacct tacaaaaagg agaaacggaa tgaacagcat cccctctatc 3298741 atcagcaagc ataaagccta ttttgcggcg ggacatacga gaccgcttga atcgagactg 3298801 aacattttgc gaaagctgaa acaagccgtc agaactcatg aagccgatct catagccgct 3298861 ctctaccagg atctccataa atccgagcaa gaagcatact caacagaaat cggaatcgtc 3298921 ttggaggaaa tcagctttgt catgaaacgg ctgagaaaat ggtccaagcc gaaacgagtc 3298981 aaaacgccgt tgactcatct aggctccaaa agcatcatca tccctgagcc gtatggaacc 3299041 gttttggtga ttgcgccttg gaactatccc ttgcagctgg cgctttctcc gttgattggc 3299101 gccattgcgg cggggaacac ggtcgttctc aagccatcag aatatacgcc ggctgtttct 3299161 gctattcttt ccaaactcat cagcagcgtt tttccaactg attatgtcgc tatggcagaa 3299221 ggcgggcccg atgtcagcac agcattatta cagcagccct ttgactacat tttctttacc 3299281 ggcagtgtag ctgtaggaaa aatcgtcatg gaggccgccg ccaaacaatt aattcccgta 3299341 accttggagc tcggcggcaa aagtccctgc atcgtccata aagatgctga cattcagctt 3299401 gccgccaaac gcatcgtctt cgggaaattt acaaatgcgg gacaaacctg catcgcaccg 3299461 gattatttat ttgtccacga ggacatcaaa acgaagctca cagaagaaat gaagcgtgcg 3299521 atcagagaat tttacggccc tcagccggaa cggaatccac agtacggcaa aatcgtcagt 3299581 gagcgccact atcagcggct gctcagcttt ctgaatgatg gcatcccgct cacaggcgga 3299641 caatctgatc ccaatcatca caaaattgcg ccgaccattc tcgaacaagt gagagatgac 3299701 tctccagtga tgcaggagga gattttcggg ccgattcttc cgctctttac ataccgcaat 3299761 atcggggaag tcattgagaa agtccaatcg cgccctaagc cgctcgccct gtatctcttc 3299821 accacaaaca aagaaattga gcgcgctgtt ttaggaaatc tgtcgtttgg cgggggctgt 3299881 gtcaatgata cgttaatgca tgttgcgacg ccgtatttgc cattcggcgg cgtcggggaa 3299941 agcggcatcg gcagctatca cgggtttgac agttttaaca cattcacgca caaaaaaagc 3300001 gtcgtcaaac aaacgaaccg tttcgacttc gcatttcgtt atccttcctc caaaaacggg 3300061 ctgcgaatga ttcgaaaaat actcaaataa aaaagcgcag atcacctgcg ctttttacaa 3300121 atccttaata caccaatcaa tcggcgcctc tcccattttc tccaaatagg cattcgcccg 3300181 ggaaaacggt ctgctcccga aaaatccgtt tctcgcagaa aacgggctgg gatgcgtcga 3300241 ttcaatgata aaatgcttgg aggtgtcgat ccgttctttt ttcatttgag catgccgtcc 3300301 ccacaaaata aagataaccg gccgctctct ttcactcagc acgtcaataa ttcggtccgt 3300361 cagtcgctcc cagccttttc ccttatggga attcgcctgt ccgcgcctta ctgtcagcac 3300421 agtattcagc aaaagaacgc cttgctttgc ccagctcaca agcgacccgt gattcgggat 3300481 gctgcacccg atgtcctgct gcagctcaag aaagatattt tttaacgaag gcggctgctt 3300541 tacaccgggc ttgacagaga agcttaaacc ttgagcctgt cccggcccgt gatacggatc 3300601 ttgacccaaa atgacgacct tgacatcatc atatgatgta taatgcagcg cgttgaaaat 3300661 atcccggctg tccggataaa tcgtttgctc cgcgtattcc ctcttcagca tctctctgag 3300721 ctcttgataa tacggtttct caaactcttc ctttagctga ttccaccagc tgtcttgtaa 3300781 aagctgtttc aagattcagg cctccttacg aacgatgaag tctggaatag acaggctcgc 3300841 catcccaaac catttcactt tttgcttccc gcctcttcat ctcaggctct tcaagcagga 3300901 cggcaaagtt tttcgtcggc agctccccga gtccgtgctt ttcacttaaa cgatccaaat 3300961 attgcttccg cttggcgcca aggtcagcag actgattgtc tcccgcgtca ctgaaggcat 3301021 aaatcacgct ggcgcaaggg acacgcttca cccggtaatc cttggccgcg cgcaaataaa 3301081 aatcccagtc ccagtaattg tgcacatcag catcgaaata cccgatttca tcatgcagaa 3301141 aacgtctgta catgctgccc gacggcacgt atgtagaaaa cactctcata tcctcatagt 3301201 cagcggtata agcaaacaat ttccgtgaca ctggatacct tgttccgttt ttctcttcaa 3301261 acgaaactat ttccgcatca gaatgaacga agtctgccgt ttctatttcc tttgccattt 3301321 tctcgatatg ccctggcgta aagaaatcat cgtcatcaca cagcataatg caatccccag 3301381 acgcctcttt tacaccggca tttctcgcag ccacatgccc cgagttcttt tctaaattga 3301441 tgacagcaat cggcagctcc ggataaagtg ctttgaccgg cacgaccgat tccccggcat 3301501 cattcacaat aataatttca tacggcatca aggtctggcg ggaaatcgac tccaaaagct 3301561 cacacaaagc cggaatccga ttataggtca caattacgat agaaatcttc atgatgctct 3301621 ccttctcatt ttcatagtca tgtactatta aaacatatat tggacgggag atcagtggga 3301681 atatcctact gaaacggcat actacaatga tagaaacagc aaagtggctc cgatcagaag 3301741 caccatgatc agcatcagat ctccaaagac atgaaagata tctttcatgc ggacgccatt 3301801 cggaaggata agacgccaca gcttagattg atagaccggc agcagcacca gtgcataaga 3301861 aagacacaaa aatgtaaaag ccggcggcac aaaagcacag cctgcatcgt cccaattcat 3301921 catgatgtct ttcatactag atccatccaa taaaaacaaa gatatcatga gggctagcaa 3301981 cacaaaggac cccaattgaa cctcaaacag gcgcattttc tggttatatg caaatcggac 3302041 cgcccaaaac cagacataag catatgaaca tagcagcgta agaatggcac ctgctgtaaa 3302101 gacgacatca ggcagccgat caagcagaaa aacaaaaggc aagctggctg ccatagccaa 3302161 gagcatgcag ccaccagtaa acaaaaatac tgccccatga gctacaaaac catataaaca 3302221 agagctaatc ctcacgacat acacctcctt tacatagaaa ttctatgtat atacctaaaa 3302281 aatcagacaa gctgacgcct gccaatataa cagcccattc ggccaaataa cggaaataac 3302341 agcgttgcaa aagcacaagt tccaacaaac caaggtgtca acaaggattg aaacagcgca 3302401 gcaggaatta cattgaatag aaaaacaagc ataaaaatga cgtttggcac cattgagatc 3302461 agaatcgtat gtagaacaag cttttctccg cgttttccaa actccttcac gccttgatac 3302521 ccaatcagca cccagtagat catatatgca gctaagatca gccaaacaga aacagaaatg 3302581 cctttccata ctgcttgaac aaacggtgat tcaagccata catgcattat tgtaatcgca 3302641 atgccgacag cgaatagggc actgttacag aaaagatgga acatcaaaaa cgcacgaaac 3302701 gttactggct gtattttctt aaacgaagaa acaatgtcag ttggtgttcc aaacgcctgc 3302761 aataaagtct gcatagcttc ctcctcactc tttccttcct gaaaagagcg aaacagatga 3302821 tgttcaatat ggctctcaat ctcttctatc atcgcctcac cctcaggaag ccctttaagc 3302881 ccgcttttga tttcggatac atatgtttct ttatccattt tgtccgctcc acttcagtat 3302941 tcggtccatc atggctgaaa atacgctcca ttccttcgtg cgttccgcca gcacttcttt 3303001 gccctcgtct gtaatccggt aatatttgcg gtccggtcct ttctcctgct tctcccagta 3303061 ggaagaaata tacccttggc gttcaagctt gtgaagagaa ggatacaagg tcccttcttt 3303121 catctgcagt tcatttccgc tgcggcttcc catttctttt acaagctcat agccgtacat 3303181 cggccgctcg ttcagaagcg tcaataccaa tataaccgtg cttcccttaa ccagctcacg 3303241 atttaacatc tcaaaacccc tacctagttt tcttatgtag cattttacga aagcccgttg 3303301 agattgtcaa atgattccta tagatcttct atattgtgat acagagaaaa tctaactata 3303361 atgaaagaca aaacatgatg gaggttcaag acatgtctat gcataaagca ctcaccattg 3303421 ccggctcaga ttccagcggc ggtgctggga ttcaagctga tttaaaaaca tttcaagaaa 3303481 aaaacgtata cgggatgacc gccttaacgg tgatcgttgc gatggaccca aacaacagct 3303541 ggaaccatca ggtattcccg atcgatactg atacaatccg cgcccagctt gcaacaatta 3303601 cggacggcat cggcgtggac gccatgaaaa caggaatgct gccaaccgtt gacattatcg 3303661 agcttgcggc aaaaacgatc aaagaaaaac aattaaaaaa tgtggtaatt gacccggtta 3303721 tggtttgcaa aggtgctaat gaagtccttt atccggagca cgcccaagcc ctgcgtgagc 3303781 aattggctcc gctagccact gtcattacgc caaacttgtt tgaagccagc cagctcagcg 3303841 gcatggatga actaaaaaca gttgacgata tgatcgaagc cgcgaaaaaa attcacgcac 3303901 tcggcgctca atatgtcgtc attacaggcg gaggcaaact caaacacgag aaagccgttg 3303961 atgttctcta tgacggagaa acagcggaag tccttgaaag cgaaatgatc gatacgcctt 3304021 atacacatgg cgcaggctgt acattctcag cagccgtgac agcggagctt gccaaaggtg 3304081 cggaagtcaa agaagccatt tacgcagcga aagaattcat cacagcggcc attaaagaat 3304141 ccttcccgct aaaccagtat gttggtccta cgaagcattc tgcactgcgc ctgaatcaac 3304201 aatcataaaa aaaggggctg ccttacagag aggcagccct ttttaaatca ccgaagactt 3304261 ttcacagaaa aaactgccga tcccatcggc agcctgttta tttgattttt aaattgtttg 3304321 cagatttcct caaaaatgtt tctatcgact gaacaaaaag tgcatattcc ttcatttgtt 3304381 catatgcccg cgtgagaatt tccgccgttt cactgtgcgg cgttgttccg ccaagcattt 3304441 ttttcagctg aagcagcaca tccttatatt cttctcgctt atcttcaact tggttagcag 3304501 ccttttccaa acattccggt gttatcttct gttcatgtat attcaagaaa acaactcctt 3304561 ttacagaaaa aaatagtagg ttatcgttga agaatagcac agatggctca gatttcacat 3304621 aagaaaatag aaggattttc tacataagtg tccaaattcc gacattcatt tcagatttcc 3304681 cggtcgcact ggctgttact tcatgatttc ccgggaaagg aaaatatctt gcactcaaga 3304741 cctcttctcc gttattgata aagatttcca cagatgacgc gtcgagaaac atgtgtacgg 3304801 tatgcaaatc cttgatgcgg caatgtctcg cttctgttct ttttccgtca aagctctttc 3304861 gttccagcgt aacaatcccc tcgtctttat ggaaggaaaa cgtagccgtt ccgcggatac 3304921 tgattgaaaa gccagactcc gtatgaatgt cttccagtag aatctcagtt ctttcaggtt 3304981 tttccactgg aagcgcacca gatgatccat gcatgttgat gtgtattttt ttctcatttc 3305041 tgcgcatggc ttttagctca ggcagcggct gctgaatcag cttctgtcct gaaagcgtca 3305101 gctgtctcgg cagcgtcatg cagtgaatcc agtggcagtc aatggtcgga tgggaccctt 3305161 catcctgatc aggcaccgcc atccatgcaa ataaaatccg ccttccctga tcgtcttcaa 3305221 gtgtttgcgg cgcgtaaaaa tcaaaacctt gatcaagctc cgtaaattca ccatgcttca 3305281 gttcaggctt gttataatcg aggcggccga caaaataacc tgattgatat acgttctgat 3305341 aacggaaacc gtcagcctca agcccttgag gcgaaacaat cagcacatcc gatccttgaa 3305401 gggaaaacaa atcagggcat tcccacatgt atccaaaatc gtccagcccg ttgaagcccg 3305461 cgccggttat cgggccaaga aatctccact ctgtcaggtt atcagaagca aacaacacag 3305521 cctgcccttt caaattctct gtttgcgcac caatcaccat ataccatgtg ccttcatgct 3305581 cccatacctt cggatcgcga aaatgcgccg tatatccttc cggaaggcgg gcgacgacac 3305641 cctttttctc aaaggacagc ccgtcgtcag aaacagcaag gcattgatac gtttcccgat 3305701 ttccatcctg atccctgaca tttcctgtgt aaaaaagata gagccgatcg tctttcgtga 3305761 cagcgctgcc cgagtagcag ccgtttttat caaaccaatc actcggagcc agcgcaatct 3305821 cttcccgctt ccaattcaca acatcctgtg tcgtataatg cccccaaaat tttgcgccgt 3305881 gccccgtctg aaacggctgc cactgaaaga atacatgata gctgcccttc caataaatca 3305941 cgccattcgg gtcattcagc agcccaaccg gcggcatgat atgaaaatgc tggcggtgcg 3306001 gatcgctgtt agcgatgggc tcttttttct ccacttcttc ataagcccgg cgacgaagct 3306061 cctggtcatg tgctgtcatt ttttcctctc ctcatcctca ttaatcttca tgacaaatgc 3306121 tgcaatgaac gctgacactg ccgcaatcgc catgccaatc agatagtgaa tcaagttgct 3306181 gaagccaaac ggagccgcaa tggcgatcat cggaattccc gttaacccgt aagcgtttgc 3306241 agctacatgt gtaaagacga catatgcccc acccaatgcg cctccgatca tcgcggcgat 3306301 aaacggtttt cggtagcgca gattgactcc gaatatgacg ggctcagtaa tgccgagaaa 3306361 agcggaaaat gctgccggaa gcgcgatttc ttttgtcttt gcctttttcg ccataaagaa 3306421 gacggcaaga cctgccccgc cctgtgcgac attcgccatt gaccagatcg gcagcaagta 3306481 gtttttgcct atatctgcaa ttagccctgc ctcaatcgca tggaagctgt gatgaacgcc 3306541 tgtcagcacg atgagtgaat acgtgccccc gaaaatcaga cctgcgacaa aaccggcatg 3306601 gtcatataca taagttaaag caaccgtaat gccggagcca agcgctctgc ctagagggcc 3306661 aatcgcgata aaagcaacaa acccggtgac aatcacagta acaaatggtg taacaagcaa 3306721 atccaccgca tgtggaacca cttttctcgt ccatttctct accttgctca tcacatacac 3306781 cgcaagcagg acagggataa cagttccctg gtagccgaga agagcgatat caaatccgaa 3306841 aagatgcatg taatcaggtg tcgcttccgc caatccccat ggatttaaaa gattcggatg 3306901 aatcatgatt cccccgatga ccgctcccaa gtatggattg ctgccaaact cttttgaagc 3306961 gctgaccccg attagaatcg gcaagaaaat gaatgctgca cttgaaaaca tatcaagcag 3307021 ctgcaaaagc gcagaatcct tgctcatcca atgaaacgca ttgatcatac ccagcaatcc 3307081 cattaatagg ccgctggcta caatagctgg gatgattgga acaaaaatat tagaaagcgt 3307141 tttcgcaaat ctcgcagcgg gattcagctt ttcttttgcc gcatcctgat gattgacgtg 3307201 ttcttcacgc tcgatatcag cttctttaga aaaggcatcg aatactttat tcacaaggcc 3307261 tgttccgaaa atgatctggt actggccaga gctgctgaaa gcccctttaa cgccatcaag 3307321 ctcttctact tgtgcttgat ctatctttga ttcatctttc atcactaaac gcagtcttgt 3307381 tgcacaatga gccgcgctga taatattttc tttccctccg agaagctcaa tgaggcgttt 3307441 tgcagtctct ttgtaatcca tctatttctc ccccttttat ttaaacaaaa aagacctaaa 3307501 attcgccaac gaataaagga cacagcgatc ctttttcatt tacgcaaatt ttaggtcttg 3307561 cctgctttac cagtcacaat cccgcttatt cagattaaga atacgctttc atcataaatc 3307621 atgatagcgt tttcgtcaac tattttttta gttaaatagt ttgatataac atgtagacaa 3307681 aaattcgtaa aaattaattg tgaaatactt cacaatatcg tgctatacta tgctcaatca 3307741 tgaaagaaag caggaaaaga caatggaaac tcaagcatta caaaaggttg aacagtatgc 3307801 tttgaaaaaa caaaacatat tcgcttcaag caaaatccgt tatgtgcttc ggtccatttt 3307861 ggccagtata tttattggtt ttggcattac agccgcaagc aaaacaggca gctatttctt 3307921 tatggctgat tctccgtttg cctttccggc agccgctgtc actttcgggg ccgctattct 3307981 gatgattgct tacggaggcg gagatttatt taccggcaac accttttatt tcacctatac 3308041 cgcgctccgg aaaaaaatca gctggcgcga caccctatac ttgtggatgt caagctatgc 3308101 cggcaattta atcggcgcca ttctgtttgc catcctgatc agcgcgacgg gactttttga 3308161 ggagccttct gttcattcct ttttgattca tttggcagag cacaaaatgg agccgccggc 3308221 ttccgaattg tttttcagag gaatgctgtg caattggctt gtgtgcctcg cctttttcat 3308281 tccaatgtct ctcaaagggg aaggagcaaa gctttttacc atgatgcttt tcgttttctg 3308341 cttctttatt tccggctttg aacacagcat tgccaatatg tgcacattcg ccatctcgct 3308401 tttgatcgag caccctgata cagtgacact gatgggagca gtcagaaact taatccccgt 3308461 tacgctcggc aatctgaccg cgggaatagt tatgatgggc tggatgtact acacactgaa 3308521 tcctgatcaa taaaaaaact tccagagatc actccctgca agtcaaagcg gttattccga 3308581 gagatcttga agacgctgga catgcagcgt gatatagccg gcctcggatt ccggcaaatg 3308641 taattgatat tcatttttca aaaactccgc cagctccagc gcacattgat aggcgaatga 3308701 atactttttt tggatgaaat aaagcatctc ctcgtccata cgatggagcg cttcatttga 3308761 ttccaaccgg ctgaccgcgt atcgcaaatg cgtgacaagg cgttgatagg aaatgctgtt 3308821 ttcatccacc tttcgattaa agtattgttt tattttctct atcatttctt tgatcatggt 3308881 cgtatgcttc agcgctgaat acatgctctc cgcatccatc ttcgccgtat ggatgtgaag 3308941 ggcaatataa cccgcttcat cttcaggcag agacacgccc aatgtctctt ttacatgtcc 3309001 gatcgcccac aggccgatct catattcttt tttatagagc gcctttatct catgcagcaa 3309061 tttattctgc acaagcagcc cattttgaat cctttcgatc gcaaaggaca aatggtcgga 3309121 aagcgcgata tgaatgtgat cgctcagcgg cgccgcgagc tctccttccg catagctgat 3309181 gatatcctca gctatttcta tatgctcctc cggcagtgtt tgcaggattt gtttgaactt 3309241 ttcattctcg tcgcgcacga caaagatctt ttccacttta ttcataggga tgagatcatt 3309301 tttctttttt tgaaaagcga ttcccggtcc catcacgatt ttttcctgat catcctcttt 3309361 tattaaagcc gcattgttgt ttaatacttt atagattttc aagaggttat ctctcccgcc 3309421 aatttgcttt tgactgggat tttacctcct tttgaccgcc atgtaaagat gcgggcccgc 3309481 tctctcctgc tttggcgatt ccttgaaggc ttgcaaacat cttcttttat aaagcgcggc 3309541 ggctttcgct ttctgctttt cttcctcatt cacagccatc cgccattcat aaaacgaaac 3309601 gagtcctgcg gcctgcacag ccgcctttct ttggtatgta cgctgagccg aatagaccgc 3309661 ggcagccgca gtttttctgt ccggcgtcac ccagttcatc aaaaagacca tccacacccg 3309721 taaagataca agcaaacgtt tcatagaaaa acatccctcc gcttcttttt ggcaggcagc 3309781 ctttttagca gcccgttttc tcagccgcag cccgcaagaa aagacggccg atttcttttc 3309841 tcgcaaacta gcggctctag caaaactcat gactctatga tagaccgtgg aaagagaatt 3309901 ctttgtcaca atatgagtga aaaaaccaac tagtttttag aagttttgtt gaaagctgaa 3309961 agaattgaaa tgaaaattgg agaaccgctt tgaaaacttt atacacaagt tatcccaaag 3310021 ataagaacaa cttaatcaca agagatatcc acatgtccac aaactctatc tatattttgt 3310081 atacgaacgt atattcctaa ctatatatat acacaggttt attcacttat acacagggtt 3310141 ctgtgtataa ctccttcgtt atacacaaac aaaatccaat aaatggtcca aatgacacaa 3310201 ggattttttt gaattttcaa gaaatatata ctagatcttt cacatttttt ctaaatacaa 3310261 agggggaaac acattgaaaa aggggatcat tcgctttctg cttgtaagtt tcgtcttatt 3310321 ttttgcgtta tccacaggca ttacgggcgt tcaggcagct ccggcttctt caaaaacgtc 3310381 ggctgatctg gaaaaagccg aggtattcgg tgatatcgat atgacgacaa gcaaaaaaac 3310441 aaccgttata gtggaattaa aagaaaaatc cttggcagaa gcgaaggaag cgggagaaag 3310501 ccaatcgaaa agcaagctga aaaccgctcg caccaaagca aaaaacaaag caatcaaagc 3310561 agtgaaaaac ggaaaagtaa accgggaata tgagcaggta ttctcaggct tctctatgaa 3310621 gcttccagct aatgagattc caaaacttct agcggtaaaa gacgttaagg cagtgtaccc 3310681 gaacgtcaca tataaaacag acaatatgaa ggataaagac gtcacaatct ccgaagacgc 3310741 cgtatctccg caaatggatg acagtgcgcc ttatatcgga gcaaacgatg catgggattt 3310801 aggctacaca ggaaaaggca tcaaggtggc gattattgac actggggttg aatacaatca 3310861 cccagatctg aagaaaaact ttggacaata taaaggatac gattttgtgg acaatgatta 3310921 cgatccaaaa gaaacaccaa ccggcgatcc gaggggcgag gcaactgacc atggcacaca 3310981 cgtagccgga actgtggctg caaacggaac gattaaaggc gtagcgcctg atgccacact 3311041 tcttgcttat cgtgtgttag ggcctggcgg aagcggcaca acggaaaacg tcatcgcggg 3311101 cgtggaacgt gcagtgcagg acggggcaga tgtgatgaac ctgtctctcg gaaactcttt 3311161 aaacaacccg gactgggcga caagcacagc gcttgactgg gccatgtcag aaggcgttgt 3311221 cgctgttacc tcaaacggca acagcggacc gaacggctgg acagtcggat cgccgggcac 3311281 atcaagagaa gcgatttctg tcggtgcgac tcagctgccg ctcaatgaat acgccgtcac 3311341 tttcggctcc tactcttcag caaaagtgat gggctacaac aaagaggacg acgtcaaagc 3311401 gctcaataac aaagaagttg agcttgtcga agcgggaatc ggcgaagcaa aggattttga 3311461 agggaaagac ctgacaggca aagtcgccgt tgtcaaacga ggcagcattg catttgtgga 3311521 taaagcggat aacgctaaaa aagccggtgc aatcggcatg gttgtgtata acaacctctc 3311581 tggagaaatt gaagccaatg tgccaggcat gtctgtccca acgattaagc tttcattaga 3311641 agacggcgaa aaactcgtca gcgccctgaa agctggtgag acaaaaacaa cattcaagtt 3311701 gacggtctca aaagcgctcg gtgaacaagt cgctgatttc tcatcacgcg gccctgttat 3311761 ggatacgtgg atgattaagc ctgatatttc cgcgccaggg gtcaatatcg tgagcacgat 3311821 cccaacacac gatcctgacc atccatacgg ctacggatca aaacaaggaa caagcatggc 3311881 atcgcctcat attgccggag cggttgccgt tattaaacaa gccaaaccaa agtggagcgt 3311941 tgaacagatt aaagccgcca tcatgaatac cgctgtcact ttaaaggata gcgatgggga 3312001 agtatatccg cataacgctc aaggcgcagg cagcgcaaga attatgaacg caatcaaagc 3312061 cgattcgctc gtctcacctg gaagctattc atacggcacg ttcttgaagg aaaacggaaa 3312121 cgaaacaaaa aatgaaacgt ttacgattga aaatcaatct tccattagaa agtcatacac 3312181 acttgaatac tcatttaatg gcagcggcat ttccacatcc ggcacaagcc gtgttgtgat 3312241 tccggcacat caaaccggga aagccactgc aaaagtaaag gtcaatacga agaaaacaaa 3312301 agctggcacc tatgaaggaa cggttatcgt cagagaaggc ggaaaaacgg tcgctaaggt 3312361 acctacattg ctgattgtga aagagcccga ttatccgaga gtcacatctg tctctgtcag 3312421 cgaagggtct gtacaaggta cctatcaaat tgaaacctac cttcctgcgg gagcggaaga 3312481 gctggcgttc ctcgtctatg acagcaacct tgatttcgca ggccaagccg gcatttataa 3312541 aaaccaagat aaaggttacc agtactttga ctgggacggc acgattaatg gcggaaccaa 3312601 acttccggcc ggagagtatt acttgctcgc atatgccgcg aacaaaggca agtcaagcca 3312661 ggttttgacc gaagaacctt tcactgttga ataagaaaaa gccctgccga ttcggcaggg 3312721 ctttttaaag atcagtcagc aaacgcctcc tgcaataagc gatacgatcg gagcttatct 3312781 tcaaaatgat gcgtgatggt caccaccatg atttcctctg tttcatacgc gttactcaaa 3312841 gctaacagcc gctccttaac ctgttctttc gtaccaacaa tcattcgatt tcgattatca 3312901 gcaattcgtc tctgttcata aggagaatac gtatttttcc gaacagcttc atacgaagga 3312961 actccctcta aaggaatacc ctgctctccc gccaaaagtg taaaatcaag cacagcccca 3313021 agctcctctg ccttctcctc cgtgtcagca caaagaacaa aaacagcaac tgccgctcga 3313081 ggcgtatctc ctaacacaga cggtttgaat cgcctcttat actgtctgac agtaccctct 3313141 ccgccctctc cattgataaa atgggcaaac atatagccag cgccagattc agctgcgagc 3313201 agcgcgcttt ctccagatga gccgagcagc cacacatccg gagccgttga aatatgcggc 3313261 gcagcggtca gattcggaaa acggtgtttg tcatccgcca aatcatgcaa atacatggtc 3313321 agctccttaa tttgctgcgg atactgatca gcattgcgct taccaccgtc attcagcgcc 3313381 catgatgcaa tcggcattcc ccccggtgct ctgccaagcc ccaggtcaat tcttcctggt 3313441 gtcagcccct ccagaacacg aaagttttca gctactttat aagcactgta atgcggcagc 3313501 atgactcctc ctgatccaac acgaattcgc tttgttttcg ctgctatatg actgattagc 3313561 acctcaggac tggaccctgc cagccgtttt gaaaagtgat gctcagaaac ccaaaatctc 3313621 ttatatccaa ggtcctcagc agcttgggca agcgcaacgg tttgctgtaa ggccgtttct 3313681 gcattgctgc cctctgatac tggagattga tctaatatac ttaatgaaac catccctacc 3313741 acctcatcct catcgtatca ctgatcccct attttttctc caaagccgct cacactgctt 3313801 atcagtgtcc cctatcattc gccatttatt tgtgaaagca tgtccctatt tgtcggaata 3313861 tgttacacgt gaaacataaa aacccctcca gacggagagg tttgctttag tttttattaa 3313921 agcccttttc tttcacgtag tcatttaaat acgtacgcgg cttttgcttc ataaagttca 3313981 gtatttgatc ggaccacgtt tcttcccgct tcccgtttgt tctttctcta tagtaatcag 3314041 aaatggtttt gtcatacgta ttcatagtat gacggaaatc gtctgtgttc acattatacg 3314101 tattttcatg ataaacggcc tgctttggca atctcggttt tttgccggaa aggttcgcag 3314161 gatggcctac tgccagtccg aaaagcggga gcacatggtc aggcgtttgc agcacctctg 3314221 tcaccttgtc caattcattc cgaatgccgc cgatatagca aatgccaagc cccatggatt 3314281 cagcggcaat gctcatattt tgcgctgcca gcgccgcatc aatcaagcta accataaaca 3314341 tttctgtatt ctcgagcagc tcagaaatat gttcaccttt ttcctcagcc agttgttgat 3314401 ggcggtacaa atccgcacaa aatacaaaaa agtgtccgtt cttctcaacg taaggctgat 3314461 tcccagcaag cacggacagc tcacgttttt tctcaggatc agaaaccccg ataatcgaat 3314521 atgcctgcac atagctggat gtagacgcag cctgcgcact tttcactaat gtatcaattt 3314581 cttcagctgt caaaagctga tcagtaaaag accggattga ccgatgattc aaaatggttt 3314641 cgattgtgtt attcatcaca aaaacctcct tatcactttt tatcatatcc gaaaaaaagt 3314701 gatctcaaaa gtgaaatgct ctgcacaaaa aaagacagcc tctgtaaagg ctgtctgcat 3314761 atcaagaatt aaaaagataa cttctgtatt tcgtcagctg cacacttgca ttatatacaa 3314821 tcccaaatcc gattaacgtg gaaagtgtcg agcttccccc atagctgaca aacagcagcg 3314881 gaatcccggt aacaggcata atgccaatgt tcattccgat attctggaat gtgtggatca 3314941 caattaacgc cgtatagcca acgcaaaaga aagaagcgaa acggttaaac ggatgtattt 3315001 tgtctatcag aacaacaagc ctgtagatta aaaagaagaa catgatgaca acaattgcac 3315061 agcctataaa gccaaatgac tcacctatta tagaaaagat aaagtcagtc gtactctctg 3315121 gaacataaac cttcaaatta gaaataccat tacctaaaat accaccagat cctattgcca 3315181 tgatggcctg gtcaacttgc cagctgtcat ttgaatcttc ctgtgtctca tttgaagcag 3315241 acacccaaga agtgacccgc ttaatttgat aatcctgtat tccaactgat ttagcaacgt 3315301 caggaaagtt tatcattact aataaaatta atgaaatgag taagatacct gaaccagcta 3315361 tgatcgcaat caatttccaa tttatccctg acataaaaac cattacaaga acgataaaca 3315421 tacatattcc cgcagtccca gcatcctgca tcaggataag acctacagga ataactgcga 3315481 cacccgcaat ctttaataac aagtggatat catccctaag cgtccgaact cctttaggat 3315541 ttgcttttcc aataactgaa gcaagcatca taatcaaacc aaccttcata aactctgacg 3315601 gctgtattgt tattctaccg atcctaaacc aactttttgc ccctttaata acaggtgcaa 3315661 tagactcggg actgatttta agaataatca aagataaaat accaatgata aaaatatata 3315721 aacttaactt ttcaagctgt tctaaatcaa agtacaaaag aactgtaatg gctacagccc 3315781 ccaaaagata aaacacaatt tgctgaatcc aatccgtgtt cccatactgc ccaaactgac 3315841 cggcagcata tattgatact acgcttataa taaaaaacac accaaatata aaaatcaaat 3315901 ccccctggta aaaggggctt tgctgtttct tatatcgact cattctatcc cgccttacat 3315961 tttcatcgga aaatcactaa tgtttattat acatgaacca cgttcaagat gacacgtgaa 3316021 gctcgcttcc ttttatgttt tttcagcatt tgcggcgctt tttcagctac acgaaatatg 3316081 acgtatcata aaccgaaatg tttcgattga cacaaaactt ttcaaatgaa aaaaacgcca 3316141 taccaataga atttgttaaa aaacgaatgc gataatgtgt tatgttccca aataatgtga 3316201 tacctcatat agaaatagct aaaaattcag agccccatgc ccatacattc tcctagcaca 3316261 ttaaacgaaa aaataagacg atagatccag tccatttctg caaaaacacg tatcaatttc 3316321 tggaaaacat ggtataataa ttgtaacaga atgttcaaaa aacaatcaca aaacagacac 3316381 aactcagttc ctctatttca tttttgtaaa cgttatcaca aaatgaaagg agacgggtat 3316441 gatggacatg ttttttgctt acttattggt tgccagcgca acgcctctct ttatttggct 3316501 tgataacaaa aaagtcgcac tctcagctat tccgccaatc attttaatgt gggtattctt 3316561 cttcttttac gcaacagaaa gcctttctcc acttggacac actctcatga ttatcttgtt 3316621 tgccgttaac gtcattgtcg ctcatatcgc cgcatttatc atttacggcc ttccgtatct 3316681 tcgcagaaag cgaagcagct gaagacagca aaaaaccctc ttccactgaa gagggttttt 3316741 tgtattattc gttatggcct gaatgctctg agtgttcagc gcctccagga ggatttccgt 3316801 ccatatggtc accatggtga tagtgagccg cgaaaatcca gatggatcca agtacgataa 3316861 cgatcgcgcc aaagaatccg aacagcgtgt ttccgacttg gatcgtgccg ttttcgctct 3316921 ctgtcatatg catgaacatg agaagctgca gcgccgcctg aatgaaggcg aagccgaaga 3316981 taatccaaag ttttgctgat gagctcaggt cagtatacac tgcaacccat agagccagca 3317041 gggtcaaaac gatagacagg ataaaaccta caatgtgttt ccatggaaag tgactgtgtt 3317101 cagcagattt gtttgccatt ttacagaccc cccaatccca tgagatagac acctgtaaag 3317161 atgaaaatcc atacaacatc taagaagtgc cagtacaagc ttgagataaa gattttagat 3317221 gaagtttgcg gagttaagcc gcgtttcttc aactgaatca gaattcctgt gatccagaaa 3317281 atcccgattg ttacgtgagt tccgtgagtt ccaagtaaaa caaagaatcc agaccagaac 3317341 gcacttgtac tgagagccgc tccttcatgt acatagtgaa caaactcgtt gatctcgcat 3317401 ccgacgaagc cggcaccgag aagaagagtg ataattgtcc aaatgactac gccttttaaa 3317461 cttccgcggc gcatttcatg aacagcgatc ccgcaggtaa agctgctgat cagcagcaag 3317521 aacgtcataa tcattaccag attgacttca aatagttcgt ctggcaagac acctccagct 3317581 gttctgtttt taagaacgaa gaaggttgca aatagtgttg agaacaacac aatttctgcc 3317641 cctaaaaaga tccaaaaccc gagaatatta agtctgccgg tttcagattg atattccata 3317701 ggcgcgttag aattgccgtg ttctgcatgt tccataactc acgcctcctt attcggaaat 3317761 ctttctttcc gtctctttta tttcatcaac actaatgtag tagccgttgt cgtattcgaa 3317821 tgaacgcaga accatgcaga gcaggactcc gatcaatccg actacgccca tccagtacca 3317881 ttcaaagaca agtccaaagc ctgcgagacc gaaggcaaca gacataaaga acggtctgcc 3317941 tgagttgctt ggcatatgga ttttcttgaa tttgctttca gggtataatt cagttttttc 3318001 ttctttcata tgcaggaatg catcttgaga tttgacttca ggaagcaccg caaagttgta 3318061 atgcggcgga atcgcagaag aagtcgccca atcaagcgta cgtcccacac cccatgaatc 3318121 tccgctgatt tcacgagtag agtaacggaa gctgtagtag atgttatagc aaaggattaa 3318181 gaatcctaca cccatcatga aagctccgac tgttgagata aagttcaatg ttgtccagcc 3318241 gtcattcggt ccgtatgtgt aaatacggcg cggcatgcct tgaagcccca agaaatattg 3318301 cgggaagaaa caaatattga acccgatcat aaagatccag aagaaccatt ttccgattct 3318361 ttcgttcagc ttgtggccga acatttttgg ataccagaaa ataaatccgg cgaaacaagc 3318421 aaatacagta cccgcaatca gcacatagtg gaagtgagat acaaggaagt acgtattatg 3318481 gtattgataa tccgctgctg ccatcgcaag cataacccct gtaaccccgc cgataacgaa 3318541 gttaggaatg aacgcaagcg cccacagcat aggtgttgta aagctgattc ggcctttata 3318601 cattgtaaag agccagttaa agattttaac cccggttggg attgagattg ccattgtcgt 3318661 aattgagaag aatgagttaa cggacgcact gttccccatt gtgaagaagt ggtgagtcca 3318721 aactaagaaa ctcaatacag agatggcgat aatagaacca accatcgctt tgtaaccaaa 3318781 caattgtttt cttgcaaagc ttgagatgat ttctgagaaa ataccaaacg ccggaagaat 3318841 aacgatatat acttcaggat gtccccaaat ccagaacaag ttagcccaaa gcatcggcat 3318901 accgcctgct tccaatgtga aaaagtgagc gccgaacaaa cgatcaaatg ataaaagtgc 3318961 taatgctact gtaagtacag ggaacgcaaa cacgataata accattgtga tcagtgttgt 3319021 ccatgtgaac atcggcatac gcattaatgt catgcctttt gttctcattt ttaagattgt 3319081 taccataaag ttgatccctg tcatcagggt accgataccg gcaatctgaa gtccgaggag 3319141 gtagtagttc tcacccggcc cagggctcat gtcgttactt gcaagcggca tataactcgt 3319201 ccagcctgcg ttcggagaac ctccgataac gaaagaaata ttgaaaagca tcgcccctac 3319261 aaagaacgtc cagaagctca ggttgttcaa gtaagggaac gcaacgtcgc gggcaccgat 3319321 ttgaagaggc acaacaacgt tgataagacc gattaagaac ggcatcgcca tgaagatgat 3319381 catgattgta ccgtgagttg taaaaatttc attatagtgg tttgagtcta aaaaactgtt 3319441 attcggaagc gctagctggg cacgcatcat cagaccgtcg acaccgccac ggaataacat 3319501 aattacagca gatataatat acatgattcc gagtttttta tggtcaacag tagttatcca 3319561 ttcagaccac agccatttcc actttttgaa gtaagtcaga acaaaaataa tggcaatggt 3319621 tgaaagcgca atggaaactt gtgcgcccag aattaatggg tcaccagtta cgaaaaattc 3319681 gtcccatttg aatttcatgc aggcttcctc ctttcctgat caatatcatt cttctgtatc 3319741 atcagacttc ttaaattcgt ttttctttac gttttcaaac ggatctgttt tagaatgcgg 3319801 tgaaacggct tgatagccaa ggcgtttgcg cgcctccatc gcgtactcag cgtcttgtcc 3319861 gtgatcaacg tatttcaagt gagtagaaga gaacgttaat tcgtccacat tttcaggaag 3319921 catcaattca tcatacttct cttttgtcag cttaggagcc tcgttctgag tctttttcac 3319981 ccagctgtta aagtcttttt ctgtgactgc attcacatca aactcttggt ctgcaaaatg 3320041 ttcacctgtg aagttcgcgt tgcggccttc gtaagtaccc actttgtcag cctgtaagta 3320101 ttgatccatc agcattcctg ccatcgcata tttttgccct ccaagctgag gaatccatag 3320161 cgaagccatt gaatctgcag atgagatttt gaacaagatc gggcggtcga caggaatgtt 3320221 taagtagttg accgtttcaa tatcctgttc agggtagcta aatacccatt tccagtctac 3320281 cgaagtagca taaacaacaa gaggctcttt gtcttttgtt gcttcaggag ctttttctaa 3320341 cgaatatatc gtctgtactg ttggcacaga aagtgcaatg acgattaaaa ttgggatcac 3320401 tgtccagact acttctaaaa acgtgttacc gtgaatttct gggttataag atccattatc 3320461 tttgccttta cggtcgcggt attttactaa aataatggta aatagaacaa agacgacccc 3320521 gacgataaac agcataaatc cgatagataa caggattaaa tcactttgct gttcagctac 3320581 aggtcctttc ggatctagta ctgaagcatt gctgcatccc ccaaggacga aaaccacagt 3320641 taacagcgct aatacaagca acggttttaa tgctctgaac aagaagatca ccatccttcc 3320701 tattgatgta ataaatctga agtgcatact tcctcaaaat cttttctcta ctttgttatg 3320761 ctatcaaaaa cttcacttat tagctttatt tttttataaa cttcatccca ttttcgctta 3320821 aatgtcataa aatcgacaaa aattgctcca actttattca catctatcgc ttaagatgaa 3320881 aagtttctag ttatttccgc atataaagta aagaaagatg atgaagaact aattctgaca 3320941 aattaaggtt taccacaata aaaaacttag gtcaatcaaa aatttcattt tgttaaactt 3321001 tctagatagg aattattttt tcctcgtcta gcatcttttc acacggttac cattttaacg 3321061 catcaaatat tgaaagaaaa ggcgcaatga agagccaata tgctctgaat tgtccgtatt 3321121 tttttatgag agcatccagt tgtttatctt atacaaaaaa gaggaatgat ataagcaaat 3321181 aaataaaaaa taggatgtgt tgcatgatga gttttcttat ttcacttatc gtcgctatta 3321241 ttatcggatg gcttggaagc ctgtttgtaa aaggagatat gcccggagga attatcgggt 3321301 ctatgatcgc aggtcttata ggcgcctgga tcggacacgg gctgcttgga acatgggggc 3321361 cgcacctagc cggatttgcc attattccag cggtaatcgg cgcagccatt gttgtctttc 3321421 tagtaagcct gttaaccaga aaaagaggat aaaagcagca gcacccgaag cgtcagcgct 3321481 ttgggtgttt gttttgccat aaaaatcgaa aaagcctcaa ccctagcggt tgaggctttt 3321541 gactggtttg gcgcccaact gatcgatgaa ccttctgaag gcctgttttc cctctgctgt 3321601 ctgcttaaat acaccggcgt gttcaaggat gcgcgcgaat acatgtccca gctcttcttt 3321661 tatgactaga tctacgttct cttttgttat ggttcttttt tccatcgtcc gaagagccca 3321721 ctcactatgc tttgcagtga gcggattttg ttctaaggct gttttcggat cagcagaaca 3321781 tagcgccgct gccgtttctt tcatttcctc ctgtaagcgg ccaggcaata tcgccaatcc 3321841 catgacctca atcaggccga tattttcttt tttaatatgg tggacttctt gatgaggatg 3321901 aaatattcct aatggatgct cctcatccgt ccggttgttc ctcagtacga tatcgagttc 3321961 gtacaagtct cccctgcgcc gcgcaatcgg tgtgaccgta ttatggggcg tatcgcctgt 3322021 ataggcggca atgccggctt tttcatcgga atacgtctgc cacgtgcgga agatatggtc 3322081 agcagcttcg gcgacatgac ccggttcgtc tccttggagc ctgagcacag acatcggcca 3322141 cttcactaag cccagcgaca cgccgggata atcatttaat tcataaacgt cttccgcttc 3322201 tgcacgtgcc attggaaaat catgcgcgcc gccttggaaa tgatcatggc ttaggatgct 3322261 gccgccgaca atcggcagat ccgcgtttga accgataaaa taatgcggat attggccaag 3322321 aaatgacagc agcctttcaa atgttttttt gctgatctcc atcggttcat gttcaccttt 3322381 taagacaatg cagtgctccg gataatagac atatggcgag aattgcagga accattgttc 3322441 gtcctcaagg atgaccggaa tgattctgtg attttgccgg gctggatgat tcacgcttcc 3322501 ctcgaagccg acattttctt tacacagcaa acacatcgga taatttgtct gttcctgctc 3322561 ttttgcagcc gcaatcgctt tcgggtcctt ttcaggcttt gataggttaa tggtcatttc 3322621 cagctcgcca tattcggtcg gcaccgtcca atgaacattt ttggcgattc tgtcagtccg 3322681 tatataatag acatcctctg aatattgata gaattccttt gtcgcctgtt ttgggccgta 3322741 taatgctttt gtctcttcaa atttgcgaat gacctcggac ggggcaggca caaaacagcc 3322801 catcagcttt gcgctgagca ggtcacggta cgtatctgta tccgcttcca ttcggccggt 3322861 ttcggcagcc catttataga tgggagctag caagtccggc aggctttgtg actgcttgat 3322921 gctggtgctg gagttcggct cgggatgtgt gatgcccagc gcttcataaa gacggtttct 3322981 cgtatattcc cgatcccaga tcgaaatcaa ttttcgttcc aggccatact caagcagctg 3323041 ttccagatgt tcaataatac tcatatgtca ctcccccttt agttctctcg ctccctctcc 3323101 gatatccgcg acataaaagt ccgctcggag ccctgttttt tcttgatatc tgtctccaac 3323161 cttctgaata aaatcatcaa cgaactcatc ttttacaatg ctgatggtgc agccgccaaa 3323221 gcctgctccc gtcattcttg atccaattac accttcgtga tcccatgccg caaacacaag 3323281 ctcatcaagt tcagggcatg ttacttcata gtcatccttc aatgaaaggt gggattcctt 3323341 cattaactgc ccgatttcat ctatattgtt ctctttgaac atatgggccg tcttaatagc 3323401 acgatgattt tcgtatacag cgtgctttgc ccggcgtctg ttcgtttcat tttggatcag 3323461 gctggaatgc gcatcgaaat cagaaggctt gatgtcgccc agtgcggcaa tatcgaggcc 3323521 ttttttcaga tcaagcaatg catcattgca ttcttggcgt ctcgtattat agctggagtc 3323581 agccaatgtc ctttttttgt tcgtgttcgc gatgaccagc gcgaggcctg agacattgag 3323641 tttgctatat tcatagtcaa gcgtgtcaca gttcagcagc atcgcatgat gttttttccc 3323701 cattccaatt gcaaattggt ccataattcc gcaattgacg ccgataaaat ggttttccgc 3323761 atgctgcgcc attttcacaa gctcaagcgc atctacttca ggatgaaaat aactttggag 3323821 cacgaccccc atcagcagtt caatagaagc ggaagacgac agtcccgccc cgtttggaat 3323881 attccctgaa aatacaatgt caaagccatg gggaactgca tatcccctct gttgaaattc 3323941 ataaatcacg ccttttgggt agttcgccca gtcgtcttct ttttgatagc gaatgtcgtc 3324001 aaggctgcat tccttgatgc ctgcgtttct aaagttatct gaatacatcc ggacaagccc 3324061 gtcgtttctt tctgcaacag cagcatatgt acccattgtc agcgcgcacg gaaagacatg 3324121 cccgccgtta tagtctgtat gttctccaat cagattcact cttccaggtg cgaaaaaaaa 3324181 ccgtaacccc tctttttctc cgaatacact tgcaaatatc ccctttagct cttcccgcat 3324241 gtgcaatcac ctttctggtt tttatttttt attcccctta tttcttcata gaaaacggca 3324301 gatcatatgc tgcagtcctc tcatacccct tcttcttttg tttttttaaa gacgagccat 3324361 ttgctcgcaa catagttgac gacaacaatg accgcgttgt cgagtatttt ggccaaggtt 3324421 tcatttgtat tgaactggcc gacaagaatg atcatcatgc ctaaatctat gccgagagac 3324481 aggacccgaa cgctgaaaaa agcagtgagc tctttcagca ggctctgcag atcatgtgtt 3324541 ttttgctgaa acacatataa tttatttgtt atgtaagcaa acagcacgga caaaatccaa 3324601 gcggcaacag tggcggcttt gtaatccaca ttcatgatct ctaccaatat ataaaagctg 3324661 gcgatattca caatggttgt gaaaaccccc ataatgatat acataattat ttctctatac 3324721 ttcactgatg ttcctcgctt tctgaaaaac ttttcaaaat tcttggcctc tcgtgctctc 3324781 tgtctaaagt aaaaaatacc gagagtgcgt ctaaaaagct gcggaaggtg gctggctggc 3324841 ccaatacata tgattgtttg atgattccgt cgaggactgc acatattatt ttagccgtat 3324901 attcaggatc aatacaggcg tcaatcagct ttctctcctt cagccactta atatataaca 3324961 cattttcttc cacccacaat tcgtacagcc ggacataggc cttgcatttc tttaagactt 3325021 tatatgtcgg catgttcatg gcaaacgagg tgatgtccca cgacggctta tttatgtaat 3325081 aggaataaag cagttctgca gcgtgttttg cagcctcgtc caatgtcagc gatttcactg 3325141 actcccgctc catttgatca agatacccta taatgatctt ttttttcatc tgacgttttt 3325201 cgagaaggta cagcagaaaa tcgtccttgc tgacaaaatg aacataaaat gctcctttgc 3325261 tgtacccggc ggctctgctg atatcttcta cagaaaccgg atcatacgct cggtcaatca 3325321 acaaattcac gccagcgtct ataaaacttt caaatgttgc ttctctttta atttgaaatt 3325381 tgtttttttt catatttttc tcctggcggt aatgattacc cttatcttac accggatcaa 3325441 tctttagcgg tatttatttc tttaaacggt tatgctattc ggtttcccag gggtcatttt 3325501 taataggcta aatgatttat tttcatttac atactatcca gtcagtattt aattgtttat 3325561 tattataaat aaggtccatt ggttatatta gtcatttttt tagggaatag gtaggtggtt 3325621 tttccttcag tttgtgaaca ccgagcaact atgtgtgaaa tttgttgtac tcgcctccat 3325681 catcgcgctg gcttgtcttt tattgcccgc atgttgcagg aaaacatttt atacaattgg 3325741 aggttactat gaaaactcat gttaaaaaag atttggacaa aggttggcat atgttaattc 3325801 aagaagctag atccattgga ttaggcattc atgatgtgag gcagttttta gaatctgaga 3325861 cagcatcaag aaagaaaaac cacaaaaaaa ccgtccggca agactagtcc gaacaggcgg 3325921 atctatttac ctctggcttt tctatcacct gatctgagtt ttcaccatat cctctattca 3325981 aaagcaaatc gctgcgctga gcttgaggac aaacggtgtg tcagctaact acgacagaca 3326041 gccggtgatg cgatcacctc ttggcacatg cattgtcata aagaggtgat gcgaacatga 3326101 taaccgtgct ctggtaaaca gcagctttgc tgagaacaag ctgcattcgg tgaggttttg 3326161 aaagcaaact cgtttataca cggccgagct tgaaaacctt cgcctgtctt tagaccactg 3326221 tgttcacctc ttcacgactt ccttcttttt tcatcctcca gctattgtac aacgcataaa 3326281 tcggactttc agtacatacc tattggtgta cctttttgct tacgtttagc gaataaaagg 3326341 aggaaagcca tgtacaaagc tgattataaa cagattgctg caacgccgtc ttttcaagct 3326401 tttttaaagc agaaacgcgc ttttattgtt ccttctgcga ttttcttttt tgttttttat 3326461 ttttcactcc ctgttttgac atcttatttc acctttttga atgcaccggc cattggagct 3326521 gtttcatggg cttggctgtt cgccatcgcc caattcgcta tgacctggat actgagtact 3326581 gtgtattccc ggagagccgc ccatttcgat aagtatgtaa gcgctttaaa agaggatctg 3326641 aagggtgaac agacatgaat atgactgctt ttttattatt tttggcgatt gttggcctga 3326701 cgcttattat cacgtatttt gccgcgaagc ggacgaaaac gacgagtgag ttttatacgg 3326761 cgggcggcgg gctcaccggc gttcagaatg gactggcaat tgccggtgac tacatgtctg 3326821 ccgcctcgtt tctcgggatt gccggaatga ttgcgttata tggatttgat ggcttctttt 3326881 acagcatcgg ttttctggtg gcttatctcg ttgtcttgta catcgtggcg gagccgcttc 3326941 ggaatcttgg aaagtacacg atggcagaca tgattgccgc tcgctttaaa gaaaagaaaa 3327001 tccgcggtgt cgcggctctc aataccattg ccatctctac tttttatatg atcgcccagc 3327061 tcgtgggggc gggcgcgctg atcaaactgc ttctagggct ggattatacc gcggctgtcc 3327121 tcatcgtcgg agtgctgatg accatttatg tcgtgtttgg cggcatgatc gcgacaagct 3327181 gggttcaaat tattaaagct gttttgctga tggccggcac actcgtgatt tcgattatcg 3327241 tgttttcgaa attcggcttt agccttaata ccatgtttga acagatgaaa acggctactc 3327301 cgcttggcgc tgattttttg aaccccggaa ataaatacaa ggtgccgctt gagaccttgt 3327361 cgttaaactt ggcactcgtg ctgggaaccg ccgggcttcc gcatatattg atccggtttt 3327421 ataccgttaa ggatgccaag acggcccgta catccgttgt gtcagcgaca tggattatcg 3327481 gtgtgtttta cattatgacg gtatttctcg gctttggtgc cgcggcattt gtcggttttg 3327541 acgcgattac ggcggctgat caagcgggaa atatggcggc tccgctttta gcaaaagcgc 3327601 tcggaggaga ctttctgttc gcgtttgtat cagccatcgc ctttgccacc attttggctg 3327661 tcgtgacagg gttggtgctg tctgccgcct cagcatttgc ccatgatatt tacagccaga 3327721 tcatcagaaa gggagaagca actgaaaaag aacaaatgaa agcggccaga tgggcttctg 3327781 tcgccgtgtc agtgctctcg attctccttg cgatttttgc acaatcctta aatgtggcgt 3327841 tccttgttgc actcgcgttt gcggtagccg ccagcgcaaa ccttccgctg attgtgttta 3327901 cagtcttctg gaaacgattc aatgcctcag gcgctttatg gggcagcctg acaggcctga 3327961 tcagcgcgct tgtgctggta tcgatgagcc ctagtgtgtg ggacccggcc ggaggtgcta 3328021 tttttaccgg tgatccgctc attccgctat ctaatccagg aattatttcc atcccgctcg 3328081 gctttctcgg cgcgtggctc ggaacggtgc tgtcgtctga taaaacaatt gatgaagata 3328141 cgtttgcaga aattcaggtg aaggcgcata ctggcgtcca tatggaacag gaataaaaaa 3328201 agctctcttt atcgagagct ttttccttac tttttcttct gctcgtcaga aatcgctttt 3328261 tcaaatacat ccttgccggc agcacccgga attacagtgt caccgataat aaaggttgga 3328321 acggctgtga tgtcagcctc ttcataggcg tgcttcaagg cttggcgctg cacgtcctga 3328381 tatgttcttg tttccagtgc tgatttgaat gatgcaccgt ctaatcccac ttcctcggcg 3328441 agcttcgtca agatgtcaat atcgccgata ttttggtcct cctggaaaaa tgcctgaaag 3328501 acacgggtgt tgtattcatg tcctttattg tattccttcg caaaatggaa gccttcaaac 3328561 gcgaggtctg tatacggatg gggcgagacg tttggaaaat tgatctcgac tcctaatttc 3328621 tccgccattg gctgaattga tgtctgccac atgtactgtt tagaaggatc attgaccgga 3328681 tcaagctgag gagatgggct tgggcgcagt tcaaacggca tccactcgac ttcaacatcc 3328741 tttcctttta tcgcttcttc aaaagcggct tttccaacaa aacaaaatgg gcagacgtaa 3328801 tctgaataaa ctttaatgtg tactgtcatg ataatctcct ttcatactaa attgatttta 3328861 aactgtaaca attaaagtta caactgtttt ttaataaaga agccgattta ggcttctttc 3328921 agattgatga caaaatccta aaaagtttta ggattttgtc atcctttcag cgtgattgaa 3328981 aacccttgaa gtctaggaaa gccgagcatt ggagcggagc gaatgctcta attcgtgagc 3329041 accaacgcac aggcttgaca acgaatgcga gggtttgtcg acacgctgaa agaagcctgt 3329101 aaaggcttct tttatgattc cagcaaacgc tgggcaatat attctccttt tttgcagccg 3329161 cctgggcatg cgtataaagc agaaccgatt gtttgtgtat attcgtttaa cgcatccttt 3329221 gctgaaagag ccttcagcat cgggataaac tgattgtcgg gatttttttg aaaactgata 3329281 aacaggagac ctgcatccat atagccggtt ttcggatcaa gtccttctgt gtaagagaaa 3329341 gctcttcgca aaatttgttt cccagtagat ttcgctagac tgacgtgtga attagacgga 3329401 atttgattca gcttcacggg atctgtttcc tttttctgcc caaaaggcgc ccccgagctt 3329461 tttctgcggc cgaaggtatc ctcttggtcc ttgagggaag agcggtccca tacctcaagg 3329521 aacattttga ttttccgaaa agccatatag gtgccgcccg tcatccagtc aggctcacca 3329581 gactgaatcc acacgatcga gttcatcaac gtgtcatcct tcgtgctctg gttgcctgtt 3329641 ccatctttaa acccgaagag gttgcgcggt gtttcaccat tttttccacc gcttaaaaag 3329701 cctttgttca caaaacggac ctcacaagtg ccgaccgctt gatttagcag gttacgcagc 3329761 gcgtgaaacg ccacttgctc gtcgtctgca cacacttgaa tgcagatgtc cccgcctccc 3329821 tgcttttcat ccaggttgtc attgggcatc gctggaagag cggctaggtg cttcggtttt 3329881 ttgcttttca gtccgaagcg gtcctttccg tctttttcaa aaaagccagg cccgaatccg 3329941 aatgtgaccg ttaagttgga aggggataaa tcagcagact cacctgtatc ctgcggcggc 3330001 agatactgat ttctctgctc cgctgacatt ttcttgccag acgtcagcat ctgtgtgaga 3330061 cttgtccagt ttctaaataa cgtaatgatg tcgcttttgt cttttgctgt tacatccagt 3330121 gcagcaaaat agacatacgt ctgatgggca gttgtgattc cggcctgatg ctttccgtaa 3330181 aacggaacaa tctgctcctc ctctttttca tcctttttcg atggcttagc cgcagtctga 3330241 acaagcggag cgagaccgcc gagaccgctg gcaccgatcg caacggctgc ccccgccatc 3330301 gctccccatt ttaaaatgtc ccgtctgtga atttgttctg gctttttctg ttcatcgctc 3330361 atgatgttac aaaactcctt ttatagcaca ttcgcaatct tcgacatggt ttcagaaaga 3330421 gtcgtcagct tagtgctcag ctctctgatt tgcttttcac ttaatttatc ataagacgta 3330481 taggactgat catttgtttt gtattttgcc attaaaactt caaattcgct gaactccgta 3330541 tccagttttt ccgtcaagtc ggagtgatct tttacaagcg cgcttttcac tgtttgataa 3330601 acggcttcgg agccttccac atttgccata aggtcaacta aatcaattcg tgagtagcgc 3330661 tcttcttctc ccgtgatttt cgaaattccg gcttcgttca gaagctccat cgcgcctgca 3330721 acaatttgtt caggtgttaa tttcagtgat tgaattgaac cgtcaagctc ttttacatcc 3330781 ttgagaagct ggtcagctgt tgccttttcc ccggaaatat cttgatcctt ccaaatggcc 3330841 ttctcaagct tatggaagcc tgtccatttg tctccttctt caacatcgtt ttctcgtgcg 3330901 tcaattttcg gatcaagatc tccgaggctt tcagcgatcg gttcgattcg ctcgtaataa 3330961 acacgcgctt tcgcatataa cgttttggac ttttcgatat cgccggattt cacagcaccc 3331021 gtaaatgctt cagtcgcttt gacaagctgg tcactctgct ctttgacata gcctttatac 3331081 tcatccgctg cttttgccag ctgatcgcta gcctttttgc cgctcttctt cgcttctgtc 3331141 aggtcttcta aggatgcttt caatgactcg gattctgtct tgatttttcc tgcatccggt 3331201 ttgtcttttt gcgcttctgt gtagattggc tgaagatgct tttcgatttc tgtatattcg 3331261 aatggatagt cgctgcgaat atcgttttca aaggaaagcc agtagctgtt taactctttc 3331321 cccttctttt caatctcttt ttggtctcct ttttccactg agtcattcag cttagaaatg 3331381 atggtttcca ttttatttac ggatgcggtg atttctttag tgaccccgct tttttcagat 3331441 gaagcttttt ctttggttga agatgtgtca ttggctccgc agcctgcgca cagcgcaagg 3331501 atgcatccgg ctgatacagc gatttttgtg aaattcattt tgtcagttcc tttccgtttg 3331561 taaaatgttt tgccgcttct gaaacaagcg caatcagtaa aaagagtaaa atcaacattt 3331621 gcggaatcgt gctgtacaca gacggataaa ttcctagcac cgatacagac ggcagccagc 3331681 tttctgcatc agacggaaga atgcccgcca gttgaaggct gtgaacgccg gttccgagaa 3331741 atttcacgca catatacagg acaaccgcca ttgatagaag aaaaaacggc ttcaatggaa 3331801 tgcgcattcc gagcttgatc atcagaacac cgacgatgac gagaacgata agccctgcgg 3331861 cagttccgcc gatcagttca gtgagcggga gcttcccgac aagcccgatg aaaaagatga 3331921 ccgtttcgag accttctctt acaactgcca gaaatgcaat gagcgcaaag gaaagcaggc 3331981 ttcgtttttt tagtgcctgt gacttctgga tattgatttt ttctctccat ttatccattg 3332041 aggcgtttct gtgcagccac accccgacat acaaaagcat gacagcggac agtacgccgg 3332101 taacgccgcc aagcaagaaa ttgttttctc cgaatacact ggaggagaac agaaccgtga 3332161 caccgatgcc ggctgctaag gaaacagcca tgccggcgga cgccccgccc cagatccatg 3332221 tcgaggaacg cgtaacccgc gctttttttg tcatggttaa tagcgctccg atgacaagga 3332281 gggcctccat tccttcacga accgggatca gcgccgcatc ccaccagctg tagctgcttg 3332341 aagcgatcgg ctcgagcaat tgaatcattt cgtcaatttg ctttgatacc ttttcaggat 3332401 ggctgccgat ctccgccttc atcagcgcca gattttcctc cgatgtcgta taggcttctt 3332461 tcgattggga cacgacatct ccctcaacag cgagccagga tgtaactaaa ttgtcgattg 3332521 cggatgacgc ttcatccaat tgtttttttt ctatgaactg ttttgtgtct ttcaagcttt 3332581 gtatataggc tgttaaggac gcccttgatt gacctgagga tgtctttttc agcacgacag 3332641 cctgctgata ggtttctaaa tgagacgcaa gctcttcaag ctgtgttttg agcttacgtg 3332701 cgtcttgatt gataaaagaa agagaaatca tcgcgatatt cgcgtccatt tcactgtgag 3332761 aagaaaggtt ttctttctta atagaaggtt cttctttttt ccacttcgcc ttgaaggtgt 3332821 caaacgtttg ttgtgccgaa tccatatccc cgtcttttac ggatttgatc atttgcttgt 3332881 ttaattgaat taatgcggcg atcggatcat cttccgcatg tgccgcagaa ccgaaaacca 3332941 tcaacaagct gaatagaata agtgccagcc cccgagccat catgttcctc ctataattga 3333001 aaatgattat cattgtataa cataatcata gccagttcct gtcctttgtc aattaaaatt 3333061 tgaaggtctg aaaaccttga tggacagcaa aaaagctgtc cttttacaga acagcccttt 3333121 gaaggaaaat gaacgattat cttcctgttt tatacgtttg aatttcctca cgaaacttgc 3333181 gtgcagcact ctcaggatcc tccgcctgac tgatggcgct gatcatactg acgccatcgg 3333241 cccccgcttg gataacaggt gcggcattat ctattgtgat tccgccgatg ccgacaattg 3333301 gaatgctgat gccttggcgg cgcactgctt cgataagaga tacaccctgt accgctctcg 3333361 tatctttttt cgtttcagtc ggatagatcg gcccaagccc gacataatcc gctccgtctt 3333421 cttcggcttg cttcacctca gacatcgtat gggcagaaac gccgagaatc atatcaccta 3333481 tggcagctct tacctctttc gcatttgcgt cttcctggcc gatgtggata ccatcagctt 3333541 tcagattcag agccaattcc acatcatcat tgacaatgaa cggaacacca gcttcacggc 3333601 aagctgcctg cgctttttca gcaaatttaa tccgagcctc tcctgtcagc gcatccccgc 3333661 ctttttcacg gaactggtac agggtggcac cgccttttaa cgctttttgt acaactgtaa 3333721 caggatcggc tttcgtattg tttgacccca taatgaagta tacagataat aactctttca 3333781 tcatttcccg agaaatacga gtcatgagac agtcaccctt tctatagtcg cccattcttg 3333841 gacgtcttgt tcagtaacag ttgaaagctt gttcagcaat tcaatctgaa agcttccagg 3333901 gcctttgtca gccgtctgct gtgcggcaag ctgagcggcg accccatacg aagaaatggc 3333961 cgcaatagca gcaaacaatg gattttcttc cacagcgcaa aacgcaccga cgacggaagt 3334021 cagcaggcaa ccggcgcctg tcacttttgt cagcagcttg tggccgttat gaagggtgta 3334081 tacatgtgac gtgtcggcta tgacatcaac ttcaccagtt atcgcaatga ccgtgtttag 3334141 cttttgtgcc gcctgctgag ccagccggat gatgtcgcct ccaccttcac ccgcatcaac 3334201 acctttgatc agccaatcgg tcacgccgac ggtatgggca atttccgccg catttcctct 3334261 gattgcagca aggcgcacct cacgaatgat gtcacgtgcc gattcagtgc ggaacggtgt 3334321 tgctccggca ccgacaggat caagaatgac gggaacgcca tgttcattag ctgattttcc 3334381 cgcgatgatc atcgcttcga ctgactcctt gctcagtgtt ccgatattta aaacgagtgc 3334441 acccgcaatt ttcgccatat cggcgacctc ttcttttgcg tacgccataa cgggcgatgc 3334501 gccgagcgcg agcaggccgt ttgctgtgaa attcgttacg acattgttgg ttatgctatg 3334561 caccagtggg ctatgccggc ggacagccgt aagacatttt gctgctgatt gtgcatccat 3334621 atttgcatca tcctttacta tcttttttcg ggtcccataa atacgatttc gtatgttcga 3334681 gccaagctct ggcggcaaac gacaagtacc tgtcctttct ccaaataatg gcgaggtgcc 3334741 aagggatgac cggatcgaca agcggaatga ctttcacttt ttccgggtca aggccgcggc 3334801 agatccgttc cggcaaaagc ccgatcccaa ggttggcgga taccatctca ctaataaaat 3334861 cccattgtga tgtttcataa atgatatggg gccggaaccc agccttgata cattccgtca 3334921 taattcggtt gtgcaggaca aaatcctctc tgaagaaaat aaaaggctcg tccttcaact 3334981 cacgcagctg acattctttc tcatcagcca gccggtggga agggtgaacg acaagcatta 3335041 aggtttcttt tacgattgta aacgaatgaa agatatcttc gtttgcggga aggaccacaa 3335101 cgccgatatc aagagagccg tccccgacac cttcttggac ttttatagaa ccgtcttcga 3335161 ctagctgaaa ggtgacattc ggatagtttt cacggaaatc gccgagcact ctggggaaaa 3335221 accccgatcc gatcatcggc ggcagtccaa tccgtacgtg ccctttcttg acttccataa 3335281 tatcatttaa ttctgacgtc aggttttgaa atgatttaat gatttcctgc gcctgcacat 3335341 acatgctatg accggcatca gtcagttcca cctgcctgcc gtttcggtaa aacagttcaa 3335401 ttccgagctc ttcttctaaa tttttgatca tttttgatat cgtcggctga gaaacataaa 3335461 gggattggga agccttcgta aaacttttta aacgggcgac ttccaagaaa tatgttaaat 3335521 ggcggatatc catgcgcttc accctttcta tagacaaaag gaatacttct tattcttaat 3335581 atatatttta cctatagaga gaccttatgt acaataagta tataagggag gcatcaatat 3335641 gaaaaaactg ttgctaaccg ttattcaaat cgctctgtta tttatatttg ctcggctgat 3335701 taattgggtg acagcccttc ttcatataaa tattcccggc agtataatag ggattgtgat 3335761 tcttttcaca ttattgcact ttaacattat caagcttgaa tggatcgagc ttggtgcagc 3335821 gtggcttctc ggggagctgc ttttattttt tatcccgtct gccgtcggag tgattgaata 3335881 cggagacatt atgtcgaaat ttggtgtcag cattctgctt gttgtcatca tcagcacgtt 3335941 tgtcgtgatg gtgtctacag gaacgcttac acaactcatc gcaaagagaa aggagaaaaa 3336001 gcatacgtgt tcatcggaat tgtaagtttg tttttaacgg ttttggtgta tttaggagca 3336061 aaaaaggtat atcaacgctt tccgcgtgtt tatacgtcgc cgctattggt gacgcccgct 3336121 gtattagtcg gtctgctgct gctggtgaat gtcccgtacg agtcctataa tctcggcggc 3336181 ggattgctga ccgatatgct acagccggcc accgtggcat tcgcgatccc gttatataaa 3336241 tatttccctg ttttaaagaa atacgcagtg gaaattattt tgaatgtggc cgtcggttca 3336301 tgcatcgcga ttatttctac cgctcttatt gcgaaatggc ttcacctcgg caccggctta 3336361 attgacagcc tcgtcccaag atcagtgaca acgccgatcg cgatgaacgt atctgaaatg 3336421 atcggcggta tgcctgccgt cacagccgtg tttgtgattt taaccgcttt gctcggcaca 3336481 gtgatcggcc cgatggtcat ccgttatttc cgcattgata acgaaattgc gcggggcgtg 3336541 ctgcttggca caagcgcgca cggagcggga acgtcaaagg catttgagct cagctctgtg 3336601 tccggcacga tttccagcgt gtcgatgatc ttagctgcga ttatgacgct ttgcgcggcg 3336661 ccgtttttgc tttcatttat gtaaaaaact gtcctctcga gggcagtttt ttttatgtgc 3336721 ttccccttat tgaaaagctg gcgaattcca atataatgta tttgtggata ccaaaggagg 3336781 caccctgatg cacaacttgc aggtgaggcg gcattatgcc gcgttaaaag gattttattt 3336841 gtttgctttt ctcggtacgg gcagcataat tcccttactc agtatgtatt taacgaagga 3336901 acagcattta agcggatcac aggtcggctt gatcatgtca ctgggcccga ttgtgatgat 3336961 tttctttcag ccgttttggg gcatgctgag cgactatacg caaaaaacga aaggcctgct 3337021 ggcggtttgc acatcaatca caggcatcat tggattagcc tatattgcat ttgacagttt 3337081 ccctctgttt attttgattg cggcctgttt tgcagccttt caaagcacga ttattccact 3337141 ttcggacagc atttcactaa ggtacacaca agaaacaaac ggcaactacg gcggaatccg 3337201 cctgtttggt tctctcggct tcggtgtcgc ggtgtttgcc atgggacagg tgacgaacca 3337261 gctgtacccc attcacgtga tctttatctt tggctgtgcc tttctgtgca ttgctgccat 3337321 attggcttca caagtgcccg gccagcagaa aacaacaaag gtcaatatcc gcaaaggatt 3337381 ccgggagctt atcagcaaca aaactttcct catctttatg atcatcacct ttacgacatt 3337441 tgctccaaac ttagcgaaca atacgtattt cagtcttttt ctggacaaaa gcggcgcgtc 3337501 actttccgct atcggcattt tatttttcat cggtgtcatt tcagaaattc catttatgag 3337561 attcgcccaa acatttatag ataaaatggg gctgctcaac gtcattatgc tgtcaggcgg 3337621 agtctcatta ttcaggtggg cgctctattt cacggcgcct tcactatgga tcatttatgc 3337681 gacggtcttt cttcagggag tggccatcgg tttatttatc ccggcggcgc ttcaatatgt 3337741 gaaaaagatt accccaagac acgttgaagc gacggcgctg accatgtacg ccgccattgg 3337801 caacgggttc ggcaactggt tctgcacatt tgcaggcggg tacatttttg actacgtgtc 3337861 gatcttcgca gtctacttgc tttttggcat tctgagcata gcaggctttg gcctgacatt 3337921 atatttaatg aaggctgaaa aaaacaaaca tacacttcat cagccggctg ttacttttaa 3337981 accataatga ctataatgaa caaaagaaag gatgtgcgtt atgaacgggc aagagcgaaa 3338041 cagcatttcg aaagggttgc aggttgatat tgtattgaaa gcagatcaaa aaacaggaaa 3338101 actgacgaga gggacagtga aggatatttt gacgaaatca aactttcatc cgcatggcat 3338161 taaagtccgt cttgaagatg gccgcatcgg ccgcgaccag cagatcgttt ctacataaaa 3338221 aaaagctgcc cctgaacagg gcagcttttt cattattttt tctgcagaag gaccactttc 3338281 aggtagttgc cttccggaaa tgccgaaatc gttttgaaat cctccggcag cgtaaattcc 3338341 tcaatgatcg tgtagcgttc atttgtttct ttaaaggcgg catcaataaa gcctttgaac 3338401 ttcttcatgc caaaggcgct gctgtttgta gaggcaacaa tgacaccctt gtcagcagtg 3338461 atggcgatcg tttccttcag caggttttta taatccttgg ccgcgctgaa ggtgcgtttt 3338521 tttgtgcgcg caaaggaagg cggatctaga ataatcagat caaagcgcaa atcctttttt 3338581 gcagcatatg aaaaatagtt aaaaacgtcc atcactttaa tgtcgtgcgc ttcgtaatcc 3338641 agcttgttca cgctgaattg ctcgatcgtt ttggcaagac ttcgatttgc cacgtcgacg 3338701 cttgttgttt tctccgctcc gccaagcgcc gccgccacgg agaatgcacc cgtataagaa 3338761 aacgtattta aaacggtttt cccttttgca tagcggtctc tgatcgcctt gcgcacatgt 3338821 ctctgatcca aaaagatgcc cgtcatggcg ccttcattca gatccaccgc gtattgaatg 3338881 ccattctctt ggatgatgat cgggaactcg ccccttctcc ctttcacgaa gtcatcatct 3338941 tcaacgtatt gtccagccgt gtcgaagcgt ttcttctcgt aaatcgcttt ataatcaaga 3339001 tccatctcat ccaatgcgga aatcagcatg tctttaaagg tgtaaattcc cttgctgtac 3339061 cattgaatca gcaggtagcc gtcataatag tcgatggtga cgccgccgac accgtcaccc 3339121 tcaccgttga acaggcggaa agctgttgta tcttgagcct caaatagttt ggcgcgcgct 3339181 tgggccgctt ttgttaattt gctgagaaaa aatgcttggt caatctgttc atgtttattg 3339241 cgggtaagcg tccagccaac ccctttgttt tgcaggccgt aatagccccg cgcgagaaac 3339301 tcgccgccgc tctcagacac gatatcaacg aggtctcctt ctttcatgtg ccccgcactc 3339361 cctgcgagag cttctttttc aataagggga tagccttttt ttattttggc agcgtgtgct 3339421 ttttttaggg tgagtagctt catatatgtc gtcctctttc cgtttgcttt ctcttatggt 3339481 accacaaaac gccaagatgt ctgcattgac agaaaggaaa ggtttttcta cgatagacaa 3339541 aaagagttac gaggaggagc agcatggcaa aacgaattga ccatacaggc atcatggtaa 3339601 gagatattaa cgcgtccatc acattttatg aagaggtact aggcatgaaa ttgaaggatc 3339661 gcatcactca cacgaacggt gtaatcgagc ttgcttttct tggctttgaa gacggcccgg 3339721 aaacagaaat tgaactgatt caaggctaca gcagcgagct tcccgctgaa ggaaaagtgc 3339781 accacattgc cctgctgacg gatgacatcg cggctgaata tacaaaagcg gaaaaaatga 3339841 acgcaaaatt tatcgacgag gagatcacaa cacttccaaa cggataccgt tatttctata 3339901 tcgaaggccc tgacggtgag tggattgagt tctttcagcg gtaaaaataa agaacgtaca 3339961 ttttgtgatg tacgttcttt tttatctata ccaactgata tacgttgact catcgcaaat 3340021 catagcttcc cagcccatac gctcaaccaa ttcatggatg tttttatctt tggctaaaaa 3340081 gacattaatg aatgagtcat atacactcat aaacacaaaa tccattttct catcagttaa 3340141 aacgagctct gttgcggctt catcaagaac cgtccgcaag ttggcttcag ttatgtccaa 3340201 aacgccgcgg ttttccacaa tcggttctgc gtaataaaac cgattggatc cgttcgcacc 3340261 taataccttt accaaactcg gaatatgaaa atttgaaata tgatcctcac tgggataata 3340321 gaggtctcca tttatgtttt catgtaacac ctcagccaaa tcctctctcg cgaactcgtc 3340381 ccttaaagcg cctatcgacg tcattaaagc cagcgccagc tcagcatgtg tttgaaagcc 3340441 gcaagaagac ataaccttct tccaggaaac agccttgcct attcctctta tttcattatc 3340501 gtttggataa atatgttcat aatcattttt tctttttgca ttctcccatc cttcaggcat 3340561 ttggataaaa ggagaaaaga taagagcagc agatgagtat tcaactggta cttgttgtaa 3340621 gattggtgat tcgtcatcta accatatata atctagcatg cgcacctcct ttacatattc 3340681 taacattcct ttcgtttgaa agagatgatc agccctatga caggctgatc atctatcaca 3340741 tcacattttt atccccagat tcaaccgcac tctcttcccg ccatttttga tgatcccata 3340801 ttctgaaaaa cggatagtag atagcacagg tgatcagcag atttaccagc tgcataactg 3340861 cgcccgacac ctttccgcct gtcgccaggt aacctgatat gagcggcggc atcgtccatg 3340921 gcaccgcgat tccggccggt cttgccacca gcccggtgct catgccgata taagtcgcgg 3340981 taatcgtgag gagcggtgcg atgataaatg ggacaataag gaggggattc atgacaatcg 3341041 gcatgccgaa aatgatcggc tcgttgatat taaatagcgc agggccgatt cctaatcgtc 3341101 caagctgctt catttgtttg ctgcgggagc gcacaagcat cgtcaggaca agcgccagcg 3341161 tcgccccgct tccgccgaca ttgatccaaa tttgaaaaaa ctgagtcgta aaaatactcg 3341221 gcagcgcctc gcctgcttgg aaggcgagac ggttggcatc catcgcgccg taccaaatcg 3341281 gcgccatgat tccgccaatg atggaagccc cgtgaatccc gcacgaccaa agcagcatct 3341341 gcacaaattc agcgatcagg cttccgccga gactgccgcc aaggatggaa agcggtgtgc 3341401 caagcaggtc tcctacgaca ttgtgcagac tctgaaaagg tgtcatttca atcagaagac 3341461 gcgccagcca tacgagaagc acaatgataa agccgggaat cagcgcgaca aatgatttgc 3341521 ttaccgcagg cggcacaccg tctggcattt tgaagacgat atttttttga ataatgtacc 3341581 gatagatttc ggttgaaaac aaggcgatca gcatggcgac aaataagccc ttgctgccga 3341641 gcagcgtgat cgggattccg ccccctacca tgatggactc cgttgagcca tgcggtgtaa 3341701 acggcacctc aaacggtgtt gccagcagaa atgcggcaat tgaaatcgct ccggcagaaa 3341761 gggcatcgac accatagctt tctgccagcc gataggcgat cccaaaagcg gcaatcatcg 3341821 ccataatatc aaacgaagcg ttaacaggat atccgagctt atcggcccac tcgttcccaa 3341881 acacactcgc catgaaatca gcataccccg gaatcggcaa gctcgttaaa atcaagaaga 3341941 cagacccgat aataatcagc ggcatggtca ggataattcc gtcacgcaaa gcgctgagat 3342001 gccgctgccc ggcaattttc ccggcgacag gcattatttt ttcctccatc acccgagtga 3342061 atgtgctcat cttaaaaacc cccttttctc attgctttgt gaacaacctc cgcaatgttt 3342121 tctttatctt attttgaaaa cgcttacaaa ttcatttgga aaatttcctc ttcatgcgga 3342181 aaaaatctgc attttgctaa acaaccctgc ccatgaaaaa ttttttcctt cttactatta 3342241 atctctcttt ttttctccga tatatatatc aaacatcata gaaaaaggag atgaatcatg 3342301 aaaaacatgt cttgcaaact tgttgtatca gtcactctgt ttttcagttt tctcaccata 3342361 ggccctctcg ctcatgcgca aaacagcagc gagaaagagg ttattgtggt ttataaaaac 3342421 aaggccggaa aggaaaccat cctggacagt gatgctgatg ttgaacagca gtataagcat 3342481 cttcccgcgg tagcggtcac agcagaccag gagacagtaa aagaattaaa gcaggatcct 3342541 gatattttgt atgtagaaaa caacgtatca tttaccgcag cagacagcac ggatttcaaa 3342601 gtgctgtcag acggcactga cacctctgac aactttgagc aatggaacct tgagcccatt 3342661 caggtgaaac aggcttggaa ggcaggactg acaggaaaaa atatcaaaat tgccgtcatt 3342721 gacagcggga tctcccccca cgatgacctg tcgattgccg gcgggtattc agctgtcagt 3342781 tatacctctt cttacaaaga tgataacggc cacggaacac atgtcgcagg gattatcgga 3342841 gccaagcata acggctacgg aattgacggc atcgcaccgg aagcacaaat atacgcggtt 3342901 aaagcgcttg atcagaacgg ctcgggggat cttcaaagtc ttctccaagg aattgactgg 3342961 tcgatcgcaa acaggatgga catcgtcaat atgagccttg gcacgacgtc agacagcaaa 3343021 atccttcatg acgccgtgaa caaagcatat gaacaaggtg ttctgcttgt tgccgcaagc 3343081 ggtaacgacg gaaacggcaa gccagtgaat tatccggcgg catacagcag tgtcgttgcg 3343141 gtttcagcaa caaacgaaaa gaatcagctt gcctcctttt caacaactgg agatgaagtt 3343201 gaattttcag caccggggac aaacatcaca agcacttact taaaccagta ttatgcaacg 3343261 ggaagcggaa catcccaagc gacaccgcac gccgctgcca tgtttgcctt gttaaaacag 3343321 cgtgatcctg ccgagacaaa cgtccagctt cgcgaggaaa tgcggaaaaa catcgttgat 3343381 cttggtaccg caggccgcga tcagcaattt ggctacggct taatccagta taaagcacag 3343441 gcaacagatt cagcgtacgc ggcagcagag caagcggtga aaaaagcgga acaaacaaaa 3343501 gcacaaatcg atatcaacaa agcgcgagaa ctcatcagcc agctgccgaa ctccgacgcc 3343561 aaaactgccc tgcacaaaag actggataaa gtacagtcat acagaaatgt aaaagatgcg 3343621 aaagacaaag tcgcaaaggc agaaaaatat aaaacacagc aaaccgttga cacagcacaa 3343681 actgccatca acaagctgcc aaacggaaca gacaaaaaga accttcaaaa acgcttagac 3343741 caagtaaaac gatacatcgc gtcaaagcaa gcgaaagaca aagttgcgaa agcggaaaaa 3343801 agcaaaaaga aaacagatgt ggacagcgca caatcagcaa ttggcaagct gcctgcaagt 3343861 tcagaaaaaa cgtccctgca gaaacgcctt aacaaagtga agagcaccaa tttgaagacg 3343921 gcacagcaat ccgtatctgc ggctgaaaag aaatcaactg atgcaaatgc ggcaaaagca 3343981 caatcagccg tcaatcagct tcaagcaggc aaggacaaaa cggcattgca aaaacggtta 3344041 gacaaagtga agaaaaaggt ggcggcggct gaagcaaaaa aagtggaaac tgcaaaggca 3344101 aaagtgaaga aagcggaaaa agacaaaaca aagaaatcaa agacatccgc tcagtctgca 3344161 gtgaatcaat taaaagcatc caatgaaaaa acaaagctgc aaaaacggct gaacgccgtc 3344221 aaaccgaaaa agtaaccaaa aacctttaag atttgcattc caagtcttaa aggttttttt 3344281 cattctaaga acaccacaca caaccttttt cccatccatt gtacaggctt ttcatactat 3344341 tgctatacag ccatgaacag cataaaatga acgttattac agttatcacc acatatggcg 3344401 ggattgtgac tgggcaggca ggcaagaccc aatgatgcaa agggagtatt aatgcctaaa 3344461 aaacagggca ttttaactct tcttttcgtg ttgggctcat aacggcgcct tggacaaccc 3344521 cctattctca tgctccgtcg tcgacgcggg catttttgtc attttcagcc ggtatttctc 3344581 acttttttca ttttgattgt caacttttca tttgatacga tgaacaagcc gacttttctt 3344641 cagcaaagga ggttttaatt gcttgcataa agagattgca aaagaattac tgctgctcgc 3344701 aggaggaaaa aacaatatta tcagcatcag ccattgtacg acccgtcttc gttttgatgt 3344761 aaaggacgag acgaaaattg atatacatgc cattgagaac ctgcaaggtg tgcagggcac 3344821 ctttttccgc tatgggcttt tccagattat cttcggagca ggcgtcgtca acaaaatata 3344881 taaagaagtc gttcatgtat gggagaccgc gccttctgaa gagcctgtcc accagaaaaa 3344941 agccagccgg aagctgaacc ctgccgcagc ttttgcgaaa acactgtccg atatttttgt 3345001 gccgattatt ccggcaataa cagcaagcgg cctgctcatg gggctgatcg gcatgattaa 3345061 ggtgtttcat tggttcgctg ccggcagccc atggattaaa atgctcgacc tcgtgtccag 3345121 cacagccttt attttactgc cgattttagt cggcttcagt gctgcacggc aatttggcag 3345181 caacccatac ctaggggcag tgattgcagg gcttttgacg catcctgatc tgctggaccc 3345241 gtctatgctc ggcagcaaaa ccccgtcttc tttagacata tgggggcttc atatcccaat 3345301 gatgggctat cagggttcca tgataccgat tcttctttcc gtttttgtca tgagcaaaat 3345361 tgagaagcta ttaaaatcga ttgtgccgaa gtcgcttgat gtcgtgatca ttccctttat 3345421 tacggtcatg gtgacagggt gcctcgcgct gattgtgatg aatcccgccg cgtccatcat 3345481 cggccagatc atgacacaat cgatcgtcta tatttatgat cacgccggca ttgctgccgg 3345541 agctcttttc ggcggcatct actccaccat cgtcctatct ggattgcatc atagctttta 3345601 tgcaattgag gcaacgctgc ttgctaatcc gcatgtcggt gtcaactttt tagtgccgat 3345661 atggtcgatg gcgaatgtgg cccaaggcgg agcggggctt gcggtattcc tcaaaacgaa 3345721 acaatcaagc ctgaagaaaa ttgcgctccc cgcttctctg accgcgtttt taggcattgt 3345781 tgagccgatt gtattcgggg taaatctcaa attgatccgt ccctttatcg gagcagccat 3345841 cggcggtgct attggcggag catacgtggt tgcggtacaa gttgtggcaa attcctacgg 3345901 actgacaggc attccgatga tttcaatcgt gctgccgttt ggcgccgcta attttgttca 3345961 ttatatgatc ggtttcttga tcgcagccgt ctctgctttt atagctacat tgtttctcgg 3346021 gtttaaagaa gagacagaat aactggattt attcgatttc attcataaaa cgggggatga 3346081 aaggacaaaa aagctatgaa aattaaaaga atcttaaatc ataatgctat cgtcgtaaag 3346141 gatcaaaatg aagagaagat tctcttgggt gcaggaattg cgtttaacaa aaagaagaat 3346201 gatattgtcg atccgtcaaa aatagaaaaa acctttatca gaaaagatac acctgactat 3346261 aagcagttcg aagagatttt agaaacattg cctgaagacc acattcagat ttctgagcaa 3346321 attatctctc atgccgaaaa agagctgaac atcaaaatca acgagcgcat tcatgtcgct 3346381 ttttcagacc atctttcttt tgcaattgaa cgcctgagca atgggatggt tatcaaaaat 3346441 ccgctgctga atgaaatcaa agtcctttat ccaaaggagt tccagatcgg cttatgggcc 3346501 agagcactga ttaaagataa actggggatt cacattcctg atgatgaaat cggcaatatc 3346561 gccatgcata tccacacagc aagaaacaat gccggcgata tgacacaaac gcttgatatt 3346621 acaacaatga tccgtgatat tatcgagatt atcgaaattc aactgtctat taatatcgtt 3346681 gaagatacca tctcttatga aaggctcgtg acccatctcc gctttgccat tcagcatatc 3346741 aaagcaggcg aatccattta cgagctggac gcagaaatga ttgacatcat taaagagaag 3346801 tttaaggatg ccttcctgtg tgccctaagc atcggcacct ttgtgaagaa ggaatacggc 3346861 tttgagtttc ctgaaaaaga attgtgctac atcgccatgc atattcagcg gttctaccaa 3346921 cggtcagtcg cacgctgaga caaacaaaaa acgcttttga tcatctcaaa agcgtttttt 3346981 tatctgattt attggttgat cgccggattc ccaatcgtat tccacttcgt ataggacatg 3347041 taatggaaat actcatcgcg atacggatgt tttgtattgg agttccaagg cttttctccg 3347101 ccgcagaagt gcacgattgc cgggttttct cttgtttcat tatattgctt ccgccctaac 3347161 agagtcgatg gggttttcag ctttaacatg atataggttt gagcgttcca gcgcggatga 3347221 agttcatacc actgatcata caagatcgca ttcagtgcat cttggtcatg cagcacaaga 3347281 aagtcttcgt ctgggtgttc attgataaag ttgatgactt tttctgtgat gttttgcttt 3347341 ctccaagact caaaatcaat aatcatgata cctgagttaa aatacttccc tgtatcagtg 3347401 acgttcattt ctttcaggcg ttcatgctgc cccgcatcct caacagcggc tacggtgtat 3347461 ggcgcaatgt ctaagtccca tagcttagaa atatcctcta ggacaagcgc atcacaatcg 3347521 atgtaaatca ttcgtttgat gctttcatcc ttaattaagt cgggaatcga aatgcggtaa 3347581 tacgcggctt ttgtaatatg gctgctctca accgcatgtt catacatgtt ggtatccact 3347641 tctaaaaact caatcggcac tccgaatttc aaagtggttt cttccagtct ttttttgtta 3347701 tcaggcttaa ttccgccatc aatgacgtat aattttacct ctctctcctg atccatgtta 3347761 gtcaataaag aaacgaacat cccacctaaa tgacgagcat aattatcatc tgcgcatgat 3347821 acgatatgca tgatttcatc tttcctcaat ggtattcatc tccctttttg ttgtacaagt 3347881 tacataccct ttttcaaaaa aataaacacg ttctccgaca tttttttaaa cagaatgtgt 3347941 gatacaacaa aaaaggtgtc attttttgaa gatgcgataa agccaataaa gaatgaaaaa 3348001 gcttgcgatt gtgatggctt cagccgagac gatataccac ggccatggcc cgagaacatc 3348061 taagagagag gaaccgcccg gttttttcgt caaatacata taattcgcgc caagccagcg 3348121 atcaatcaga aaaatacaga cgccgtacac attaacaagc aggactgtca cccataacga 3348181 gcgctggccc attctgtagg tgccaatcac agccatcagc agacaggata aaaacacaga 3348241 cccgtgagaa ataaaaaaga ggatatatcg gatatgcgga aatgaaaaca taccgaggtc 3348301 aggagtggca agagcctgaa tcgaactgcc gatgccgaca aaaaacaaaa acacaaacag 3348361 ctttctgctt tttgtcacta acataatagc tgacaaatac accgacaggt cactaagctg 3348421 gagaggcaat gaagtgcgca ccgaccacct gtccgtggcg accatccata tttgatagcc 3348481 gatttgcgaa ccaagcaaaa gaaacacaaa cagagaacgc aaaaaccggc tggccctcgg 3348541 ctgcttgacc tcatcttgga acaaaaacaa cagaatggcc aaaagggaga taatcgctaa 3348601 cgtcactaca tgctctgtcg aaaacagatg aaacggatca tgcttatagt cggattgaac 3348661 atatttttgc aaaactgcac ccccgttttc gggtttttgt ttattttggc gttgtttggg 3348721 ctttttttat tcaaccgata tatgggcttg aagttcacac cagactctgt taaaattcgt 3348781 ttcatagcta atgattctga taatttaagg caggcctaaa aaatggaacg ttcacatcaa 3348841 catcagcagc ttcggaagga agaacacgat acactttcta agctcaaaca aatgcccgtc 3348901 gagtcactca acctggaagc catttcgatc gctacgaatc tgtatcggtc tgcacaaagg 3348961 ctccgtgtca aaatggagac tgaggttctt tctacctata acctttcttg gaccgctttc 3349021 tccattcttt atgatctatg ggtatgggga gcgctcgaaa cgagaaaaat cgctgagctg 3349081 tcagggatat ctacagctac agcaagcaac gtgatcaaaa cgctcgaaaa aaagagtttt 3349141 tgccgtaaaa gcatcgacac aagagatcgg cgactcgtgt ttgtctcaat caccgattcc 3349201 ggcaaacaag cgatcgaaga actctacccg gagtttcaca aaggggaaac agagctcatt 3349261 gcgggaatga cgaaggacga acagaaaata ttgacagggc tgcttagaaa ggtagctgac 3349321 aatcttcata caacataagc tttgacggga atccagtagc ggtttgtctc cctgtttcag 3349381 agagccggcg gtaggtgcga gccggcgcac aggcaaacgt gaattacctc cccaagcttt 3349441 ctttgtgaac cttagtagca aagaacggga aaccgttatt cgaatgagcg gaagacaatg 3349501 tcttcaacca gggtggtacc gcgtgcattg agccacgtcc cttattggga tgggctcttt 3349561 tttgtgtttg taaaaaagga ggaaaaatga tgagaacatt tgagcagctc acagcgtcac 3349621 aacaaaaaga ggtagaaaga cagcttcagc tatacatgac aggcgcccac gaagtcatac 3349681 cgccggagga attaaaggca aagctcgtga aatcaatttc cacgggcacg ccgcttaaaa 3349741 ttaagctcgg attagatccg tctgcaccgg atgtacattt gggccatacg gttgtgttaa 3349801 ataagcttcg ccaatttcaa gaaaacggcc acattgtcca gctgttaatt ggggatttca 3349861 caggaaaaat tggtgatccg accggaaaat cggcagccag aaagcaactg actgatgaag 3349921 aagttcagca caatgccaaa acctactttg agcaattcgg aaaagtgctt gatccagaaa 3349981 aagtcgagct tcactataac tcaaaatggc tgaaaacatt gaatctagaa gatgtcattg 3350041 aattagcagg gaaaataacg gtagcccgcc tgatggagcg cgacgacttt gaagaacgca 3350101 tcgccatgca aaaaccaatc tcactgcatg aattctttta cccattgatg cagggctatg 3350161 attctgtcgt tctcgaaagt gatattgaat taggcggaac ggatcagcat ttcaatgtcc 3350221 tcatgggacg gcatttccaa gaacgataca acaaagaaaa acaagtcgtc atccttatgc 3350281 cgctcttgga aggcttggat ggcgtcgaga aaatgtcgaa gtcgaaacac aactacattg 3350341 gcattaacga acatccaaac gacatgtacg gaaaaacgat gtcactgccc gacagcctga 3350401 tgaaaaagta catccacttg gcgacagact tagagcttga agagaaaaaa cagctcgtaa 3350461 aagacttaga aaccggcgcc gttcatccgc gtgatgccaa aatgctttta gccagaacaa 3350521 tcgtccgaat gtatcacgga gagaaagcag cagaagctgc cgaacactcg tttaaaacag 3350581 tctttcagga aaacagcctg ccggaagata taccggccgt aaactggaaa ggcgaaaaaa 3350641 cgatagcgat gattgatctg ctcgtcaagc taaagctcct ctcttcgaag agcgaggcgc 3350701 gccgcatgat tcaaaacgga ggtgtacgca tcgacggaga gaaagtaaca gatgttcacg 3350761 ccaaagcaga gataagagag aatatgatca tccaagtcgg caaacgcaag tttttaaagc 3350821 tccaataatc tgatattccg aaacgcttat gacccttcat tcataagcgt ttttttgcag 3350881 gtataaagca ctgtcttttc aaaaacgctc tccatcttgc aggaaactcc tttagcatcc 3350941 cgaaatattc cccaaccata catttagggg aggtttattt ttgatgaaaa agcttttgac 3351001 tgtcatgacg atggctgttt taactgccgg cacactgctc ttgccggcac agagtgtcac 3351061 ccctgccgcg cacgctgtac aaatatcaaa tagcgagcgc gagcttccat tcaaagcaaa 3351121 acatgcgtac tctaccattt ctcagctaag tgaagcaatc ggccccagaa tagccggaac 3351181 tgcagctgaa aaaaagagtg ccctattgat cgcctcatca atgagaaaat taaagcttga 3351241 tgtgaaggtt caacgattca acattcctga ccggcttgag ggtacactgt cttcagcagg 3351301 acgcgatatt cttctccaag cggcgtcggg ctcagctccg actgaggaac aagggctgac 3351361 ggccccgctt tacaatgcgg gattgggcta tcaaaaggac tttaccgctg acgccaaggg 3351421 caaaatcgcc ttgatttcca gaggagacct gacttattac gagaaagcca aaaatgccga 3351481 agccgccgga gcgaaagctg tcatcattta taacaacaaa gaaagcctcg tgcctatgac 3351541 gccaaacctg tcgggaaata aagtcggcat tccggtcgtc ggcattaaga aagaagacgg 3351601 cgaagcactt acccagcaaa aagaagccac cttaaaacta aaagcattca caaaccaaac 3351661 ctcccagaat atcatcggaa tcaaaaaacc aaagaacatc aaacatccag acattgtgta 3351721 cgtgaccgcc cattacgaca gtgttccttt ttcgcccgga gcaaatgaca acggctcagg 3351781 tacctctgtt atgctggaga tggcgcgtgt cttaaaaagc gttccatctg ataaagaaat 3351841 ccgctttatc gctttcggcg ccgaagagct cggcctgctc ggctcctctc actatgtaga 3351901 tcatctatcg gaaaaagagc tgaaacgaag cgaagtgaac ttcaacttag atatggtagg 3351961 cacaagctgg gaaaaagcgt ctgagctgta tgtcaacaca ttggatggcc aatctaacta 3352021 tgtttgggaa tccagccgta cggctgctga aaaaattggg tttgacagcc tgtctctgac 3352081 acagggagga tcatctgatc atgtgccatt ccacgaagcc ggcattgatt ccgctaactt 3352141 tatttgggga gacccggaaa cagaagaagt tgagccgtgg tatcataccc ctgaagactc 3352201 gatcgaacat atcagcaaag aacgcctcca gcaagcaggc gatcttgtga cagccgctgt 3352261 ctatgaggct gtgaaaaaag agaagaaacc gaaaaccatt aagaaacaaa tgaaggcgaa 3352321 agcatctgac atttttgaag atatcaaata aaaaaagacg gcacttgggt gccgtctttt 3352381 ttaatccact tctttcttaa tccccagcat tttctcatct aggtaatggg caatctccgc 3352441 ggcttctttc agctcatctg ttaattgctt aggaacgtca ttgttcaatt tataataaat 3352501 tttatgttca aggctcgccc agaaatccat cgcgattgtc cggatttgaa tttctgcttt 3352561 gacgtattcc acacggttcg ttaaattcac aggcatctca atgattaaat gcaggcttcg 3352621 atagccattc ggtttgggtg tctggatata atcctttacc tttacgattc tcaaatcttc 3352681 atgctgcttc aacacattca cgacattata aatgtcagaa ataaaggaac agatgatgcg 3352741 cacgccggca atgtcgtgaa tatgctcctt catttccttc gtcgtaatct cacagccctt 3352801 tctcattaac ttattcacga tgctttcaaa gctttttaca cgggattttg tatgttcaat 3352861 cgggttgtgt ccgtgaatga ggttatattc ctggctgata attgagaact ttgtatcgag 3352921 cgcatctagc gcaaatttat aaactaataa ctcatttttc caatcttcca ttactgtttt 3352981 taaatcgtcc atatgtgtta cagataaatc catgttcgtc atctccttta acggaacttt 3353041 atccgctgtc catgtactag acgtccctgt ctgctgcaag gttctatgaa tttttttaca 3353101 aaatgcggtc gattgtaaca aaaaaagacc gcatgaaacg agcggtcttt tttattatcg 3353161 gaaatagctg atcaataatc cgatcgagag caggaatccg aaaaatgtat ttgtttgggc 3353221 tgttgatttc attgcgacaa tcatattcat cggcatttcg ttctggacga agcccttcac 3353281 tgcctgaacc ggcttaggca cgctcaaaaa gacgacaaac agccatgggc ttgcggcacc 3353341 ggtaataacc aagccgacaa cccagatata agcgacggca aacgacgcag ctaacagagt 3353401 aacagctccc ttatgcccca tcaaaatcgc caatgttttg cgtccgcctt ttttgtcctc 3353461 ttcaatatca cgaatgttgt tcgacaggtt aatcgcgccg acaagaatcg caatcgggat 3353521 ggaaatcaaa atgctctgca tattgatctt atctgtctga atgaaaaacg aaatcagcac 3353581 aaacaccgaa cccatgcaaa tgcctgagaa taattcaccg aacggcgtgt acgcaatcgg 3353641 cagcggcccg cctgtataca ggtagccgat cgccatgccg acaaggccga tcagcgcaag 3353701 ccaccagctg ctgctggcac aaatatagac accgagcaaa atggcaatcc cgtatgaggc 3353761 aagagctaat tgcaaaatcg ttttaggctt cattccgtgg cgtacaatgg cccctccgat 3353821 tccgactgat tctgctgtat ctaatccgcg tttaaaatca tagtattcat taaataagtt 3353881 cgtcgcgatc tggatccata ggcaagaaaa cagcatagcc aaaaacagca gcagatcaac 3353941 cttcacataa aacatcgcca aaacggttcc gagcagcaca ggcacaaacg atgcggttaa 3354001 cgtatgagga cgggttaact gccaaaggat ctgccccatg ctttcttttt gcggcgctgt 3354061 ctgaccctca cccttatttg tttggttcat cttcctcttc ctttctatta aaaggcttac 3354121 tttttttcag ccggcagctt aataaaaaac tccttttgct tccttatcta tcataatgac 3354181 ttctccctta tttcacaaga taccgcaaga aggcgttttc tttcttatta tacgcttctc 3354241 gccctgattt cattaggttt ctgctttcac ttgaacgaac aggtacagaa aaattttttt 3354301 aagtacatta cactttttaa aagttaaaaa gatcttttga ctccaggtat cttttccttt 3354361 attatgaatc agctcgaaac attccattct tgcccttgca ggtataaaga ttcattttca 3354421 aaaacatacg ccgatatatt aatttgaggg agattaggga aaaaatgaaa ctttttgagc 3354481 atctgatcgt caaataatca tgtgattgtc gaaaaaacgg gaagggaatt tttgatatgc 3354541 tgcaattaat gaaacagctg tatgaaaaac ccgctgtcaa gtggacatgt catacaggct 3354601 tttatttgat gatactgctt gttttgtttt ttatgtatgg ttttcacacc gcgaataccg 3354661 gttcatatat ttataacgat ttctaattgg agagagaata actatgaaac ttttacatgc 3354721 tattcaaaca catgcggaaa cttatccgca aaccgatgcc ttccgctctc aaggccagtc 3354781 gctcacgtat caggaattat gggagcagtc tgaccgcgcg gctgccgcga tccaaaaacg 3354841 catttctggg gaaaagaaat ctcctatcct tgtgtacggc cacatggagc cgcacatgat 3354901 cgtttccttc ttgggaagtg tcaaagcggg acatccttat attccggttg acctgtctat 3354961 tccgtccgaa cggattgcga aaattatcga aagctctgga gcagaattgc tgatccatgc 3355021 agcaggactc tcaattgatg cagtcggcca gcagattcag acagtttctg cggaagaact 3355081 gctggaaaac gaaggcggct ctgtcagcca agatcaatgg gtcaaagaac acgaaacgtt 3355141 ttatatcatt tacacttccg ggagcacagg aaatccgaaa ggcgtgcaga tttccgctgc 3355201 gaaccttcaa agcttcacag actggatttg tgcagacttt ccagtcagcg gaggaaaaat 3355261 atttttaaac caagcgccgt tctcatttga tttgtctgtc atggacctat atccgtgcct 3355321 tcaatcaggc gggactttac attgcgtgac aaaggatgct gtgaataagc cgaaagtctt 3355381 atttgaagag ctgaagaagt ccgggctgaa tgtgtggaca tcaacacctt cctttgtgca 3355441 aatgtgcctg atggatccgg gtttttcaca ggatctgctg cctcatgcgg acacatttat 3355501 gttttgcgga gaggttcttc cggtttctgt ggccaaagcg ctgcttgagc gttttccgaa 3355561 agcgaagatt tttaatacgt acggcccgac tgaagcgaca gtggctgtca catcggttga 3355621 aattacgaat gacgtcatca gccgcagcga atcgcttcca gtgggcttcg ccaaaccaga 3355681 tatgaacatt ttcattatgg atgaagaggg acagccgctt cctgagggag aaaaaggaga 3355741 aatcgtcatt gcagggccga gtgtaagccg aggctacctt ggtgagccag agctgacgga 3355801 aaaagcgttt ttctctcatg aaggccagtg ggcataccga actggcgatg ccggctttat 3355861 tcaagacggt cagattttct gccaaggacg tttggatttt cagattaaac ttcacggcta 3355921 tcgaatggag ctggaggaaa tcgagttcca tgtcagacag tcacagtacg ttcgttctgc 3355981 tgtcgtgatt ccttatcagc caaacggaac agttgagtat ctgatcgctg ctattgtgcc 3356041 tgaggagcat gagttcgaga aggaattcca gctgacaagc gctattaaaa aagagcttgc 3356101 cgcttctctt ccggcatata tgatcccgag aaaatttatc tatcaggatc acattcaaat 3356161 gacggctaac ggcaaaattg accgaaaacg cattggcgaa gaggttcttg tatgacgcct 3356221 tacagctcgt ttttattctt tatactgctt ggcattcttc ttctgccgac gatcattctc 3356281 ggcttaaacg gaaaaagatt tcaagcatac aacatgttca tatctatcat tatattggct 3356341 ttaatttttt cgcacgactt acacggggtc atcgcgctgt gcctgtttac aatatggcag 3356401 gtgctcctga tcagcggcta tctggcatac cggcagaaag cgaacagcgg ctttgtcttt 3356461 tgcggagctg ttatcgcgtc tattctgcct ttatttctgt caaaaatatg gccgtttctt 3356521 tcacacccgc agccgcatca tccgccgcat aacctgatca gctttttagg gatttcatat 3356581 ttaaccttta aaggcgttca gctgattatg gaagcaagag acggactgct gaaagaacag 3356641 ctgccattgc accgtctgct gtatttcatc ctgtttttcc cgacgatttc ctccggcccg 3356701 atcgacagat accgccggtt cgtcaaggat gaacagaagg cttggacgaa agaagaatac 3356761 gccgacctgc tgtatacggg aatccataaa atcttcatcg gtttcctgta taaatttatt 3356821 atcggctacg cgatcaatac gtacttcatc atgaatcttc ccgcaatcac gcacaataag 3356881 attcttggga acctgctgta catgtacggc tacagcatgt atttattctt tgatttcgcc 3356941 ggctacacga tgtttgccgt cggggtcagc tacattatgg gcattaaatc accagaaaac 3357001 tttaataaac cgtttatcag taaaaatatt aaagatttct ggaatcgctg gcatatgtct 3357061 ctgtcatttt ggttcagaga ttatgtgttt atgagattcg tattttggat gactaagaaa 3357121 aagtggatca aaaaccgtat ggccgtctca aacatcgggt atttcctgct gtttatgctg 3357181 atgggggttt ggcacgggct cgcgccgcaa tatatcattt acggcctcta tcacgccgtt 3357241 ctgatgacgt gttacaactt tttcgagaag tggaataaga aatataaatg gctgccgtcc 3357301 aaccgctgga caaccattct cgctattgtg atcacattcc atttcgtttg cttcgggttt 3357361 tatattttct caggaaaacc atttcatcac caccattaaa ggagattaga aagctatgga 3357421 ttttaaacaa gaggtattag acgttttagc agaggtttgc caggatgaca tcgtaaagga 3357481 aaatcctgat attgaaattt ttgaagaagg tttgcttgat tcttttggaa cagtagaatt 3357541 gctgcttgcg attgaaaacc gttttgatat tttagtgccg atcactgaat ttgaccggga 3357601 cgtttggaat acacctaaca acattgtaaa tcagctgtct gagttgaaat aatgaaaaag 3357661 cgttttttcg gtccaattat tttggcgttt attctattcg caggcgccat cgcaattcca 3357721 tcttcatggc tgacaggctt catcaccgat aagcgtgtga aagagtcagc aacagccttg 3357781 aatccgagta tgtttcaagg gctatattta caagatcaga tgctcaaaga tccgacatat 3357841 cttccgattt acgggtcttc tgagctttct cggctggacg agttccaccc atctaattat 3357901 tttcaggtaa acaatgaggg attcacgcca taccttgtcg gcaaaggcgg atcccagtca 3357961 ttgattcatt ctttaaactt cgctgcccac atggatcagc tgaagggcaa aaaaatcgta 3358021 ttcatcgtgt ctccgcaatg gtttattaag cgcgggtctg atgaacagca tttcgcgccg 3358081 aactattctg cgctgcaagg gcttgatttg gcatttaacg atcagatcga tcctgaaatt 3358141 aaaaagaaaa tgatgaaacg catgcttcgc tttaaggctg tgcaaaacga tgccattctt 3358201 tctgagctgt acaaagcaat ggtaaacggt cagacgtgga aagtgaacgc gctgaagccg 3358261 gcggcgaaag tgtattacag catgctggaa aagaaagatc tgtattattc aacgacagaa 3358321 tcatccgggc caaagcgcta tatctcgcag tcagtaaagg ataagtcatg gtctgaattg 3358381 aataaactag cggatcaatc gggcaaacgc cactccggtt ctaacgattt tcacatcgac 3358441 aaccctgtct ataaaaagct gaagccgaaa gtgcctaagc tgaaagggaa aaacaaagga 3358501 agatcgtatg cggtgtcacc ggaatatggc gactttgaaa tgatgctcga tatcctgaag 3358561 gatgcgggcg cagagcctat gtttgtcacc attcctgtta acgggaaatg gtacgattac 3358621 acgggcttcc cgaaaaaagg acgcactgac tattacaaaa aggtaaataa acaaatcaga 3358681 gcgaagggct tccaggttgc tgatttctca gggcatgaat atgacccgta tttcatgaaa 3358741 gacaccattc acatcggctg gaaaggctgg gtgtatgtcg ataaagcaat tgacgaattt 3358801 tataaaaccg gaaaagtcac ttcatcctga gcatctcata ggacgcggct gcatatttcc 3358861 tgctaagatt tgtaatagta aaggaatcac agccaactta attaagaggt gttacatcca 3358921 atgaagatga caaataatac ggttttaatc acagggggtt ctgctggcat cgggcttgaa 3358981 ctggccaagc gcctgctgga acttggcaat gaagttatca tttgcggacg cagcgaagca 3359041 cgtcttgcag aagcgaagca gcagctccca aacatccata caaagcaatg tgatgttgca 3359101 gaccgttcgc agcgggaagc attgtatgaa tgggctttaa aggaatatcc gaacttgaat 3359161 gttctcgtca acaacgccgg cattcaaaag gaaattgact ttaaaaaagg gacagaggag 3359221 ctttttgtgg acggtgatga aattgaactt aatttccaag cgcctgtcca tttatccgcc 3359281 cttttcacac ctcatttgat gaagcagccc gaggcggcaa tcgttcaggt cacatccggg 3359341 cttgcgttta acccgttagc tgtttatccg gtgtactgcg caacaaaagc ggcacttcac 3359401 tcgttctcgc ttacgctcag acaccagctc cgcgacacga gcgtggaagt gattgaaatg 3359461 gcaccgccta tggtggacac gggcttaaac caaaaatcac gcgataaaca aggcctgacg 3359521 taccggggca tttcatctga agaatatgtt caatatttct tggacggctt gaaggaaggc 3359581 aaacaggaga ttacaaatga acgtgttgaa ggtcttcggg atgccactcg cgccgattat 3359641 gacaggttat tcgagcaaat gaacacgcag gagaattaat ttctcctgct tttttcatat 3359701 gaatttctta caaatttgag caaacctatt gcgattattt gttgaaggta tacaatagaa 3359761 tataattatt ttcaaataag tttgataata taaacaattt aacagcaggg agattgacca 3359821 tgactaaaca aacaattcgc gttgaattga catcaacaaa aaaaccgaaa ccagacccaa 3359881 atcagctttc gttcggaaga gtgtttacag accacatgtt tgtaatggac tatgccgcag 3359941 ataaaggttg gtacgatcca agaatcattc cttatcaacc cttatcaatg gatccggctg 3360001 caatggtcta tcactacggc caaaccgtgt ttgaagggtt aaaggcttac gtgtcagagg 3360061 atgaccatgt tctgcttttc agaccggaaa aaaatatgga acgcctgaat caatcaaacg 3360121 accgcctctg catcccgcaa attgatgaag aacaggttct tgaaggctta aagcagcttg 3360181 tcgcaattga taaagactgg attccaaatg cggagggcac gtccctttac atccgtccgt 3360241 tcatcatcgc aaccgagcct ttccttggtg ttgcggcatc tcatacgtat aagctcttga 3360301 tcattctttc tccggtcggc tcttattaca aagaaggcat taagccggtc aaaatcgctg 3360361 ttgaaagtga atttgtccgt gcggtaaaag gcggaacagg aaatgccaaa accgcaggaa 3360421 actatgcttc aagcttaaaa gcgcagcagg tagccgaaga gaaaggattt tctcaagtac 3360481 tctggctgga cggcattgag aagaaataca tcgaagaagt cggaagcatg aacatcttct 3360541 tcaaaatcaa cggtgaaatc gtaacaccga tgctgaacgg gagcatcctg gaaggcatta 3360601 cgcgcaattc agtcatcgcc ttgcttaagc attggggcct tcaagtttca gaacgaaaaa 3360661 ttgcgatcga tgaggtcatc caagcccata aagacggcat cctggaagaa gccttcggaa 3360721 caggtacagc agctgttatt tccccagtcg gcgagctgat ctggcaggat gaaacacttt 3360781 cgatcaacaa cggtgaaaca ggagaaatcg caaaaaaact atatgacacg attacaggca 3360841 ttcaaaaagg cgctgtcgca gacgaattcg gatggacgac cgaagtcgca gcgctgactg 3360901 aaagcaagta agaaaaaagc cggcccatta caggccggct ttttttacgc ttcaattttg 3360961 ttgaaaaact gcggcagata cgctttgtgc gcctctagca tttcgtctaa aatctgtttg 3361021 gccacagtat cggacgggac aagcgggtta atcgtcatgg caaggagcgc agtttgatag 3361081 tcacctgtaa ctgccgcttc tgccgcgaca cgttcaaagg atttgatttg ctggacaagg 3361141 ccgcggacag acaccggcaa gtcgccgaca gcaattggct tagggccggt tttcgtcatc 3361201 acacagttca cttcaactgc ggaatcgtct ggaatactcg ctattgcacc attattgatc 3361261 gtgttcaccg gctgaatgtc atgtttatca ttataaatgg agctgattaa gttacatgct 3361321 gcatcactgt agtaagctcc gccccgtttt tccagctgcg gcggtttgat cgcaaggttt 3361381 ggatctttat aaagctcgaa cagctctttt tcgaccttct gtacgacttc agcgcgggtg 3361441 ccctccgttt gtgatgcttc cagttcgtgc tccagcatct cttttgtttt aaaatagtaa 3361501 cggtgatagc cgcaagggat gacattgagc gcttttaaga aatccggttc ccattcggcg 3361561 cctgagatat ttttcatcgt catcgcgttt ttcgggtcgc ccatcgcctc gatgacttgc 3361621 tccttcacac ttacgccgtc caagaaaaca tccagcccga ataccatatg gttcagtccg 3361681 gcaaattgga cttctacgcg gtccacatct acatcaagcg ctttggctac gcccattttg 3361741 atgccgattg gaacattgca aagaccgacg actttcttca ggttggagta gcgaagcaag 3361801 gcttctgtta ccatgccggc agggtttgtg aagttaacaa gccaagcgtt cgggcaaagc 3361861 tcttctatgt cctttgcgat ctcaaggatg accggaattg tgcgcaatcc tttaaacaga 3361921 cctcccgggc cgtttgtttc ctggcctatc actccgtatt ttagcggaat gcgctcatcc 3361981 tttgctcttg cctgcaaaag tccgacgcgg aattgggtcg tgacaaagtc tgcgtctttc 3362041 agcgcctttc tccggtcgag cgtaagatga atgtcaatcg ggacgccagc tttttcaacc 3362101 atccgtttgg cgagtgtgcc gacaatattc agcttttctt cgccctcggg gatatcgaca 3362161 agccataatt cacggacagg cagctcatca taccgtttaa tgaacccctc cactagctcg 3362221 ggcgtatagc ttgaacctcc gccaatcgtt acaatcttca atccttttgt catatgcttg 3362281 ctcccctttg ctcggtgatt ttttcatata actcaatgat ctctgcagcc atatccttca 3362341 ctgtcattgc attcattaaa tgatcctgtg catgaaccat cagaagcgtc atttccgtct 3362401 tttctccgcc cgcttcattt tggatcagct ctgtctgata atgatgggct tttgacaatt 3362461 cttcagcagc gtcttgaagc tttttccgcg cttcttctgc gtcaccgctt ttcgcagcgg 3362521 caatggcctc cattgcggag ctcctaccgt ttcctccgtg aaggatgatt tgaaaaatga 3362581 tttgttccat ttcctcattc acgcgattca cttcctttct ctacagagcc gcttctttgt 3362641 catctgttgc tgcaggcgtt tggaccagct ccagatcgtt ttcttctttc agcttctgct 3362701 tatcccacat tctgaagaat ggatagtaga caacaaagga cacggcaata ttaatggctt 3362761 gcatgaccgc gcctgagact tttcctcctg tcgccaagta gcctgaaaag atcggcggca 3362821 tggtccacgg cactgcgata cccgccggtt tggcgacaag gccggtgctc attccgatgt 3362881 acgtgagtgt cactgtgaca agcggcgtga tgataaacgg aagtaagagc attgggttca 3362941 tgacgatcgg cattccgaat ataatcggtt cgttaatatt gaagatggcc gggccgaccg 3363001 caagcttccc gagctgcttc atttgtttgc ttcgggcgcg caggaacatc gtgacaacca 3363061 gtgccaatgt ggcgccgctt ccgccaatat tgacccagat atcgaaaaat tgctgggtga 3363121 aaatcttagg aagctcctca ccggcttgga atgcgatccg gttggcatcc attgcgccgt 3363181 accaaatcgg tgccatgacg ccgccaacaa tgtttgcacc gtgaaggccg caggcccata 3363241 aaagcatttt gacggcttcg gcgacaaggc ttcctccaag gcttcctccc agaatggaaa 3363301 gcggagtccc caataaaacg cttacaatat tatgaaggct ttcaaacggt gtcgcttcaa 3363361 caatcagccg ggctgcccaa attaggaaga tgacggcaaa gccggggatt aacgcgacaa 3363421 atgacttgct taccgccggc gggacaccgt ccggcatttt gaagactaaa ttgcgctgga 3363481 taataaggcg gtaaatctct gtggacacca ttgcgataat catggcgaca aataagcctt 3363541 tgcttcccat gagcgaaagc ggaatcccgc cgccaaccat gatttctttc gtcgcgccat 3363601 ccggcataaa cggcacttga taaggtgttg ctaataaaaa tgccgcaagg gaaatggctc 3363661 cggccgacaa ggcatcaaca ccgtatttct cggcgagccg gtaggcaatg ccgaacgcgg 3363721 cgacaagacc cataatttca aaggtcgcgt cgactgggta ggccagtttt tcagaccagg 3363781 agctgccaaa cgtttttgcc ataaactcag cgtatcccgg gatcgggagg ttgccaatga 3363841 tgaggaaaaa ggaaccgatg ataatcaggg gcatcgtgag gatgatacca tcacgcagcg 3363901 cctgcaaatg acgctgtccc gcaattcttc ccgctatagg catgaccttt tcttctaaga 3363961 tctgattgac tttattcaca tagcccgccc ctctctatga cacatgtcca agctgttcag 3364021 ctgatttcag cacttccgcc ccattgcacg ttccataatg gacggtatta atgacgtcta 3364081 ccggaacccc ctttgactct cctaattttt tgagctgcgg aagcatgtaa cggacttgcg 3364141 gaccgagaag caatacatcc gctttatcga tatgattttg tacagaatcg cctgaaactg 3364201 cccaaatggt atagtctttt ccctgttcct gcgcactttt ttccatcttg ctcaccagta 3364261 agctagtaga catgcctgct gcacaaacga gtaatatatt catgtaaaag accccctaga 3364321 gtttgatcaa ttttgtaatg tcctgctgtt gctatcatca tattatgaaa tcgctttcat 3364381 aaacactcag ggtttttccg caggcaacgg aaaaaaggta tatacaggct gtcagctcag 3364441 cattttttgg tcaaacacat ccgaaagctc ttgatatgaa cggcatttga tcagctggtt 3364501 catcgccgcc gggtcatcca aaatgctgcc aagcagttta tacatgcttt gtaaatccgc 3364561 tttgttctcc ttttcgacac aaagcagaca gacaaattga actcgctgac tctcccaatc 3364621 gatcggtttt ttgagcgtac aaacggccca aaacgttgtt ttcgtctgcg gaacaagcgg 3364681 gtgcgggatg gcaacaagat tgccaaaaca cgttggcgac atgtcttctc tttcaaaaat 3364741 ggaatctatg atttcttcat cggcaaagcc gcattcgacc actttctgcc ctaaaaattg 3364801 aatcacttct tcttttgagc gcagatcctc ctgaaaaaaa acgagttctt tttttaggta 3364861 gcgattggct ttttcctttt catcactcag aatagattct atttttgtaa agtcagttcc 3364921 gcctaagatg gtgttaacct tcagtactgg tacagggagc tcttttttaa tcggaatggt 3364981 gctgatgaca aaatcaattg attcgtagga catttgatca agactataat actcagccgt 3365041 tccaagaata tcgagccgct tgccgaaatg ggaacgcagt ttttcgcgca gaagctgggc 3365101 gcttccggct cccgatgcgc atacaatgat acagcgtttc ggcgggcttt ctgttttttt 3365161 tcgttcaatc gcggcgccaa agtggagagc caaatatcca atttcgtttt catgaatctc 3365221 aatacccgtt tgttccttta tcacgattcc ggcaatgatc ccggcttcaa aagcgagtgg 3365281 ataatgttcc ttgatcgctg ccagcatcgg atttcgaaga ttcatgccgt atcggttgcg 3365341 gctgatcgcc ggcttcatat gcagtgccaa gccgattttc agctctttgt catgcaggat 3365401 gccaagcttc agttcacgat caacagcttt gatcatggca agtgtcagct gatcggtttc 3365461 ctcttctatt gaaaatgtgt cctctccgca ttgtgattgt gtcattcgtt ttgtgccaag 3365521 gagatgcatg gtgatgtagg ccgtctcgtc tttcggaaac gtaacggaaa gctttgattc 3365581 cagctctttt acgatggctt ctgcagcctg gtactccttt tgatgcagga tatgatccat 3365641 atctttcggg aaaagagaaa catagttttc cgttctgatc cgtttacagg cgatagcgat 3365701 atggataatg aggttattca gtcccatgtt ggacagaggg atgcggtcgt ttttcatttt 3365761 tttcaagatg gcggaacgga tgatctcaat ttcttctttt ggcaaaatat cagccttttc 3365821 atttaaaaca tctatctccg tttctctttc atcaacaatg tactccgcca tgcagtacct 3365881 catctgcacc tcgtccccgc gcagcttgaa gccgtaattc ggacgtgttt ccatgacgat 3365941 gcggtaaggc agcagacgtt tctttacttc ctttaaatcc gtttggagtg tagattttga 3366001 gataaatagt tcttcagcaa gttcatcgag cttgagataa tggtccgcca gcagcagacg 3366061 tttcataaga taggccattc tctcctccgg caataccggc aggccctttt tttgctgaaa 3366121 ttcatcttgc agcagtgttc tgaatacttg ctcgtcatca atgcggagct tgtagccgga 3366181 gcctcttaca gattgtacaa aggcaccgtg gccgcttagc acaccttgaa gttcctttat 3366241 atcattgcgg actgtccgcg tcgttacgtt taattgcgcg gcaaaaaacg aacttgtcac 3366301 cggggcttca gccgccatca gcaagcgcag aatatcacgt agtcgcccat gaagcatgag 3366361 aaaaacctcc taactagtag atgcagggat tcagtgaata ggcagaaagg atgatgaagg 3366421 gatgcgaaat gtatataaat tctataatgg agagaatggc aagtcaatga acatccggag 3366481 gactagaggg aaaactgacc tataaaaaaa cagccgggat cagccggctg ttctagatgc 3366541 ggacatattc ttttgtttag acgccttgcg gtccttcatg atttttcgaa caatcgggta 3366601 aatgaccggc gcccatttga taacggtttt gatcatcttt ttcaaagctc cgattctccc 3366661 ttcttttttc tcaaccattc ccctgattgc ctcttcctta aacatgctaa cgcgacacgt 3366721 acctgtttcc cgtcacccag aaacgccatg gataatcgcg tgcctccccg ctgttgtcaa 3366781 tgccgatgcg cgggccggtt gaaattgctt ccggtgtgta cccgctttcg atgtaaagcg 3366841 gctgttccgt gatccagcgt ccgtagtcat tcatcgtgac gccaagcgct ttcgtcagct 3366901 ttcctggtcc gtttgtccat tccctcggac tcctgcccgg ccttctctcc tccattaaca 3366961 gctggccttc atgcggctca atcgccctga ttaatactgc ttgcgggaca tcctcttccg 3367021 ccgcaacgac attcagcaat gtatgggtgt gcatcacgta tgtatatacc cgcccagctt 3367081 ctgcaaacat gatctcagtc cgcttcgtcc ggcggttgtt aaagctgtgg gccgctctgt 3367141 ctccagcccc catataggcc tctgtttcca caatatagcc tgacgctgtg ccttcgtctg 3367201 tttcttttac aagaaggcag cccagaagcg atggggcaag ctcaagagcg gttttttgat 3367261 aaaacgtgat gggcagcgga tttttttctc tcgtcacgaa tcgacctctc cttttaccga 3367321 tttttgtaca ttgtaccatt cccgaagcag atcaaaaaaa acggctgttt taaaatcttt 3367381 ccattcaggg aatattgtta ccgttcaaaa aaggagggcc aaccattgaa agatgatcat 3367441 caaaacaagc agcaccaatc aaatgcccaa gggagcgagg aagcgttttc tcataagaca 3367501 tccgggaaaa acgagtcaga ggatacctta acgaataggc aggggcatcc tgttactgac 3367561 aaccagaatg tgagaaccgt cgggaataga gggcctacaa cacttgagaa ctatgatttt 3367621 ctcgaaaaga tcagccactt cgaccgggaa cgcatcccag agcgggttgt tcatgccagg 3367681 ggagcaggtg cacatggata ttttgaagcg tacggaagct tcggagacga accgatttca 3367741 acatacacaa gggccaagct ctttcaggaa aaaggcaaga aaacaccggc atttgtccgt 3367801 ttttcaactg tgaatcatgg aaaacactcg cctgaaacat tgagagaccc gcgcggtttt 3367861 gctgtaaagc tatatacaga agacggaaac tgggatttgg tcggaaacaa cctgaaaatc 3367921 ttttttatcc gcgacccgct gaaatttccg gatcttgtac acgcatttca gcctgatcca 3367981 gtgacaaaca tccaggatgg tgaacgtatc ttcgatttca tttctcaatc tcctgaagcg 3368041 acacacatga tcaccttctt gttttcgcct tggggcattc cggccaacta ccggcaaatg 3368101 cagggttcag gcgtacatgc ctataaatgg gtgaatgagg agggcaaggc cgttctcgtg 3368161 aaataccatt ttgaaccgaa gcagggcatc cgcaacctga cacagaagga agcagaagag 3368221 attcaaggga aaaactttaa ccatgccaca caggatctat atgacgcgat tgaaaatggc 3368281 gattatccag agtgggaagt atatgctcaa atcatgagcg atgatgagca tcctgaactg 3368341 gactttgatc ctcttgatcc aacaaaactg tggtataaag acgatttccc atggaaaccg 3368401 atcggcaaat tggttctgaa caaaaatccg gaaaactacc atgcggaagt ggagcaagct 3368461 tcatttggaa cgggagtgct tgtcgacggg cttgattttt cagacgacaa attgctccag 3368521 gggcgtacgt ttgcctactc tgatacgcag cgctaccgtg taggcgcaaa ttacctgcag 3368581 cttccgatca actcgccgaa aaagcatgtc gccaccaacc aggaaggcgg gcaaatgcaa 3368641 tatcgggtcg atagagcaga aggacaaaac ccgcacgtca actacgagcc atccattatg 3368701 ggcgggctga aggaagcgaa gcaagacgga aaagaccata cgccgcatgt cgaaggtgat 3368761 gtaaagcgtg aagcgattga cagaacaaac aacttcggac aggctggaga aacgtaccgg 3368821 agatttactg aatttgagcg gaacgaattg attacgaatt tggtgaatac gctttctacg 3368881 tgccgaaaag aaattcagga tcaaatgatt gagaatttca caaaagctga tcctgactac 3368941 ggaaaacgcg tagcagaagg gctaaaaaag gtctccgaaa acaacagcaa cgggccgatc 3369001 ggcacaactg aaacggaaca ggctgcaaag caggctgaac aggagagtca tccgtctgat 3369061 ccgtattaac aacagcgaac agggcttttt tagaagccct gtttttttat ttttctattg 3369121 aaacgctttc aataattgtg ttgtacttgg aaggaaaggg gtggagagat acgatggaat 3369181 tacagcagga cttgattcct cagaaaaaaa caatcggcgc tttagatcac gccgtttttt 3369241 tatgcatggt attttgtttc tggttttcag gctatattta cgttcctgta ttcagtctgt 3369301 atttggagga tctgcacttt tcatatggcg caatcggcat cattctcggc agctacgggg 3369361 tcacgcaaat ccttctgcga ttcccgctcg gccttttgtc agacatcctg ttttccttgc 3369421 gcaagcaatt gttaattgcc gggttcggct tttccgtcct cagcagcctg ctttttctga 3369481 tgtttgattc tttcttcttc gtgctggccg cccggctttt cgcgggaatc actgcttcta 3369541 cgtgggtgat ggcgaccatt ttatacgcac attatttcaa caatggcaat gcatcaaaag 3369601 caatgggcat catgcagttt tttaccgtca tgcctcagtt tgccagcatt gtgttctgcg 3369661 ggctcgccgc agcccattta gggaggcagg ttcctttttg gatggcgctg gcagcttctg 3369721 ccgcaggtct ggtgatctgc tgctttattc aggatccgtc tgctcctccc gcaaaccgtg 3369781 gcaccattcg tgtcaatcag tacatcaaag atacattgcg gctgccaaag ctgaagcttt 3369841 tcaccatcct gtctatgacg gcccatgccg tattatttat cacagtgttt ggttttacgc 3369901 cgctttacat gaatcagctc ggaatgggcg acgcggagct gctttgggtg atgagcgcct 3369961 ttttcctccc acacgcagcc gccacattaa gctttgtgtt tctgcgcttt acaagccgta 3370021 tcgcttactc cgtgatgctc attagtttcg ctgtcaccgg ggtctgtttg ctatatgttc 3370081 cttttttagc tgcattgttc acggtttgca tcacacacgc ctgtattggg ctggcgctcg 3370141 gcttcgtttt tcctctgctg ctaagccatg tcgtcgaaat cagttctgcc cgtttaaaaa 3370201 tgtcagtgat ggggttttac caatcatttt atgcgctagg catcttcctc gggccccttc 3370261 ttgccggaaa aatcgcacag cttatcgggc ttgcgggagt tttttatgga gccggttctc 3370321 tggcatttgc cgcctttttt gtgatgctcg cgcaaaaacg taacatgatc aattaatagc 3370381 tttcataccg ccggaagcgc cacacagaaa acacggccag aagcatgatg cacagaatgg 3370441 agaaagtgag tgaccatccg aaaaaatctg cccgctctcc atgaagaagg atatgctccg 3370501 cctgcttgca aatctcagcc ggaagccact tcgcaccatc tggaaatagt gaaacagcaa 3370561 aggaaacggc tgctgtgagc ccgatcccgc aagccgcagc tgctccgaca gaccggaata 3370621 tcgtacttcc ggcaaggccg gcggtcacaa taaatatcac ccaaagagcg taaaggccaa 3370681 ggcttgcggc aaagcggctg aatgatgcgt cctcaaacag cagccggacg taatagtaag 3370741 caagcccgta tccagctgca aacgacataa tgccgatcac gctttggatg agccatttac 3370801 tcacgatata atgggctgcc gtcacaggcc gcgacataat cagcgctgtt accccttgat 3370861 ttctttcatt ggctacactg cccatcacgc taaagatgac cagagccatg ccaagcgtgt 3370921 tgaattgaga aagcgtgctg accatcactt cagacccgga gggcatcgta aaactgattt 3370981 tcatgccgtc aggaaggttc cctccatgtg cgatgatttc cggcatataa taaatggtca 3371041 gcggctgtgt cagcccgacg atcatcatcg caatcggcag ccaaatcagc ttgccgcttt 3371101 tccatccttc cagccactcc ttctgcaata gcgccatcat caccttcatg cgtgcaccac 3371161 ctttagatag acgtcttcta gagactccgt tttctgttca aagcgggtga cggtcaatcc 3371221 ctttcggata cagtcactta ataatgaccg gccagcgtgt atatcaggca gctcgaaaac 3371281 cgcttgggac ggattcttat agacaatagc tgagacgtaa ggcttctctt caagccaacc 3371341 ttccagcttc tctttcactg aaagggtaaa aacgttcgtt tgctgctgtt gtttcagctc 3371401 ctgtaactcg cctttccatg aaatctcacc gtttttcata atcaccactt gatcacacac 3371461 ctgttctgca tcgtgcaaaa catgtgtaga aaacagaacg gccatatgct ttttcagctc 3371521 ccgcatcatg tccagcacct cgaaccgtcc tgtcggatca agcgcagaca ccggttcatc 3371581 caatatcaaa aacttcggtt tatggagcag tgcctgtgcc agaccgagtc tttgtttcat 3371641 gcctcctgaa tagcccccga tccttttgtg cgccgcttcg tgcaaaccga caaattccag 3371701 catctcgccg attttctctt ggcattttct cttcgaaagg ccggacagtc tccccgcaaa 3371761 tgtcaaaaat tcatttgcgg tcatccacga ataaaaagca ggatactgcg ggaggtaccc 3371821 aatcaaacgc cgatccagct ttttctctcc taacagcttt atggttccag aggttggcga 3371881 aagcagtccg gccagcattt gcagagtcgt ggttttgccg gctccattag gtcctaatag 3371941 tgcgacacac tcattttcat tcacgtgaaa actgacattc tttacagctt catggtgcct 3372001 gtacgatttg cataatgatt caatagacag catatcggct tacctttgct ttctgccgac 3372061 ggtgaaaaat aaaatcggcc cgataatatt gatacatacg atgattgcag cccacatcca 3372121 ctttggcccg ttcgtccgct cttcttttat acagctgata agggcaaaca ccgccaaagc 3372181 cagctgtaat acaatcagcg gcaaaatcat ttcccaagaa atattcattg cttgatcccc 3372241 cttttcttcc gatccggcct aatgacaaaa aagtaataac aaatcagagg catcggtgct 3372301 tgaatcaatc cgacaatccc ccaaacccat gccatgtgat tacgtttttt cgcatcaata 3372361 aataaaaaga ttccctgcgc caatacgatg agacaagccg caaccgttat gataatttct 3372421 gtttgtgtca tccgcgtttc acctcgcatt cgccgagatg cctttttttc tcagccgcaa 3372481 tcaaaatcgg cagcaccgca agcacacaaa cctgaagcac aataaacaca gcaggagctt 3372541 gagtgaaagc taagattgca gcactcacaa ccatcagcgc gcagaataca aataaaatga 3372601 tctcttgaag aagttttttt ctgtattcag ctttcatttg tgacagctgg tgaagcagtt 3372661 ctttttgatt cggtatagag ggattggctg tttgatcaat ttttttccat tctgacttta 3372721 aatgatcaga aagcttttct ttattcatca tcccactcct ttctgatttg ctggagccct 3372781 ttatgaactc tggactttac agtgccttct ttgatttgaa gcatcacccc gatttcagcg 3372841 taggtatagc cgtagtaatg ccttaataaa accggtgtgc gcagtttagg gtccagcttt 3372901 gaaaacagat cgagcgtttc gctccactct gcccctttcg ccgacacgtc ccacttgatc 3372961 ttgcggattg tttcctccgt aactgtctga ttccgtttcc attctctctt tctctttttc 3373021 tggtgatcga gatagagccg cgatgcaatg gagatcagcc atgtggagaa ttttgaacgg 3373081 ccctgaaagc ttcttaaatg gatgtaccct ttcagaaagg tttcctgaac aagttcctcg 3373141 ctgagatcgg ggtgaaggga aagctttaac aagtatttat ataagaaaga atagtgatag 3373201 tggaaaaggg ctgtaaacgc ctcgtcgttt ccctctttcg cctgctggat cagccgctgt 3373261 tcttcttgtg tatccaatga ccgtgatccc cccttttttg tttttctgcc ttatgagacg 3373321 acaccggatt caaaagcgtt catctttttt acaattcttt tcagccattg acagatcagg 3373381 cttcccggcc gtttggctgc atatccttat ttgtaaaccc ccttatagtc tgttaagcta 3373441 tgactttatg tcgatttcaa aaaaacatcc aatatggagg acgatgcatt gaaagtagaa 3373501 aggcgaacga ttgaatatat tccgaatgaa gaaagacatg gtaaagcgaa agatttattt 3373561 cccgtatggt tcggggctaa tatgcatatc accacgttag tgaccggcac gattcccgtt 3373621 gcaatgggac ttaatctgtt ttggagtgtt gccgctatta tttgcggaac cttaatcggt 3373681 gccatattta tggcttctca ttccgcgcaa ggccctcagc taggcatccc gcaaatgatt 3373741 caaagccgtg cccaattcgg cgtaatcgga gcgattcttc ccctcttctt agtcatgttt 3373801 atctaccttg gtttcttcgc aagcagcacg attctggcgg ccggaacctt aagcagcttt 3373861 gttcccatcc cgggatcatg gagcattata ggcttaagtg ccgtatgttt tttactcacc 3373921 attttcggcc atgatttgat tcacaaaatg caaaaaatcc tttcttggac ctcttttgct 3373981 gtattttttg ctgcaacgat tctcattttt caattgccga ttccggcagg cagctggata 3374041 cccggagcga ttgatctgcc aattttccta gtggcagtca gcgcagttgc gacgtggcag 3374101 cttgcctacg cgccgtatgt tgccgattat tcaagatatc tgccagttaa aacaccggct 3374161 tcaaaaacat tttggtacag ctatgcaggt acatctgtca gctccatctg gatgatgctg 3374221 ctcggcgcat tgctgacaac ctcacttcct gactttacgg caaactcagg cagccagatt 3374281 gtccaattgt tcggtccctt ctcgtttatt atgctgatca ttgtgctatt tgggcaaatg 3374341 gcaatcaatg tttttaacct gtatggggct ttcatgtcca cgacaacaac gctggagccg 3374401 tttctgaaat taaaagtcac gcccaaagtc agaatcatca tgatcctggg tgtcacgctt 3374461 gtcggcacag tcttaagcct actgggacag agcaatttta tggaactgtt tttgaatttt 3374521 atctttttca tcagttattt cttaattccg tggacggcaa tcaatttagt cgattactac 3374581 ttcgtccgcc acggaaagta tcaagtcaaa gccatgttcg acgtaaacgg gccttatgga 3374641 aaggtcaatt ggatcaccac aattgcgttc gttctgtcta tcttgctgga aattccgttt 3374701 atcaacacaa gcttttacat cggaccgctt gccaaaatgt ttggcggcgg agacatcgca 3374761 tggattatcg gcttggccgt gccttctgtg ctttactatg tattaatgaa accgcgtctg 3374821 aaaaaacggg cggggtatca agaaaagctg tcttctctct gaagacagct tttttatcat 3374881 tcaaatcgtt tccacacgcg gggcaggatg tcagatagct catgagcgag caacgtatga 3374941 gcggagtgct cgtccgtcca gagctcggcg cacgcaccat gcaaatagac cgcgtttaat 3375001 acggcgtgct ttggatcttc atggcagcag agcatcccca atatcatgcc cgtcagcgtg 3375061 tcaccggttc cgcccttggc gagcgccccg tttccggttg gattgagcca gcagtctcca 3375121 tcaggaaacg cgatgacggt ttggtttcct tttaacacaa tgacagtctg cagctgagcc 3375181 gcccattcct ttgcatattc cgctcttttt ttctgcaatt cgttcacggg cacccctgtc 3375241 attcggaaaa actcgcccgg gtgcggcgtg aggatgacgg ggccctcccg tttcggatat 3375301 gtgcgcttcg ccagcgctcc ggcatccaaa ataacaggac aatcagccgt aagcacatga 3375361 tcgactgcct gctgtacgct ttccgtttgc ggaaggcccg gtccgatggc aatggcccgg 3375421 tacgtctctt caagctgagc atccgccgcc tttttccagc cgtcacgcca ataggtcgcc 3375481 tcgggcaaaa caggaacaat tagcgggatt acgttttctg atgtaccgat gacaagcttg 3375541 ccgagaccgc tccgcatggc cccaagccct gcaagcagcg ctgctcccgg catgtcgtca 3375601 cttccagcca gcagcaaagc cgtaccgtac gtgcctttat ggctctccgc atctctttca 3375661 ggaagcgtgg cccttacatg ctcttccgtc caaaatggaa cattcatctc tatccctcct 3375721 ctgctttctt ttcctatttt tcctgtccct tttctttttc aaacaaaaaa gacagccttt 3375781 tagggctgtc ttttatttta caggaacatc aaggtgatac aggcggcgat atcgttcgtt 3375841 tgccgccagc agctcctcat gggttccttc catttctgtt ttgccgtttt cgagaaatac 3375901 gattttatcg gctgcttcca ctcccgcgag atggtgtgta atccataaaa tcgtttttcc 3375961 tttcagcacc tcaaacaccg tttccatcaa ttcacgttcg gtaataggat cgaggccgac 3376021 tgttggctca tcgaggatga tgatcggtgt atcctgcagc aaaatcctcg caagtgcgat 3376081 ccgctggcgc tctccaccgg aaaaacggat gccggtttct tgtacagagg tatgatatcc 3376141 gtcaggcaat gactcaatgt agtcatgcag cttgacctgc tttgcggcgc ggcgcacatc 3376201 ctcgtcgctt gcttctccgt ttccgagcct gatgttgttc aaaatgcttg tatcaaacag 3376261 gtgcggtttt tgatttaaca cggccaccgc atccgcaatc tgatccttta acagcgctgt 3376321 ctccactccg tttaacgtca cagaaccgga gtccggtttc aaggcgcctt cgattaatgc 3376381 aagcgatgtt gatttcccag agccgcttcg gccgagcagc gccatttttt ctccttggcg 3376441 cagcgtaaag gaaaagttgt gcagcacttg gctgctgttg tcataagaaa acgtcacatc 3376501 acgaaaggcc aaggtgacat cttgaagatc gagaatttga tcccctgatt cagtttgtga 3376561 cgcctccggc tgaggagcca cattgttcat gcgtctgata gaatcctgat agcccggcac 3376621 ttcgcctaag gcatccgaaa gcggcaaaaa ggcttccgtc aacggaaaca ccactagcac 3376681 aaaagcggca atcatcgttt tagcgagctc gccgtccgct tgctgtcccg ctgtccaaaa 3376741 cagcatcagc aaaataaggc cagcgacaag gcattgcgca gcaaagtccc gccatcttgt 3376801 aaagcgttgt tttttccgtt caagctcaaa ccaatcacgt tcctcttttt cataagcatc 3376861 aataaaagca tgccggcgtc cgctgaacat ccagtcgctg acacccatca cagcatctgt 3376921 cagacggctg tacagcacat tccgtccgct tttcagcttc gcattcttcg ctctcgtcac 3376981 gagcaaagac acaaccggaa acaatacaac aagaacaaac aaatacagcg caagcaatat 3377041 ggcaaacggc caagagaaga agccgagcgc tatcactgac acagcataca ggagcaaggc 3377101 tgagatcgca ggaaaaatcg tttttaagaa agcatcctgc aaatgctcaa tatcctcaga 3377161 caaaatgccg agcatatccc ccgtgcgaaa acgggaacgc agcatcaaag cacccggctc 3377221 aagcatattg taaaggcgga cgcgcatgtc agatacgatt ttcaaaatga tgtgatggcc 3377281 gacgagccgt tccacatatc gcgacacaga gcgcgcaatc ccaaaggtgc gcacagcgac 3377341 aatcggcaca taaatgagca gaatgttttc cggccttgtc gccgctttag aaatcaaaaa 3377401 acctgaggtg aacatgagaa aagcagcaga aaaaatcgtc accgcaccca aaaagataac 3377461 cagaacgaac aggcgggcat tttgcttgat atacggcaaa atccattctt ctttcttcat 3377521 gctctttccc ccagttgtgc cttcacgagt ttggtataca caccgttttt ctccagcagt 3377581 tcattgtgag tcccaatttc cgcaaccctg cccccgtcaa gcacgataat ttcgtccata 3377641 tcgagcatcc agtgaaggcg gtgagtcgcg agaaagacga gcttatcctc aaataaatcc 3377701 agcatcgttt cttttatttc atattctgtt tcgatatcaa gatgggcggt cggctcatcc 3377761 agcagcagga tcggacggtt tcccaaaaag gcgcgggcca gcgcgacacg ctgtgcctgg 3377821 ccgccgctga gcgcccggcc gccttccccg atccgcccct ctaatccgtc aggaaggttg 3377881 ttcaccagct ccgtcagtcc cgctgaggca gcagcacgtg ttgtatcctc tgccgaagcg 3377941 cttggatggt agaagcgaat gttgttgcca agcgtatcat caaaaatgta cggatgctgg 3378001 ggaatgtaaa gaaggttctt ctgccagctg ccgtcctgca aatgggaccg gcttgtacca 3378061 ttaacctcaa tcatcccgcc atccggctct aaaaatccgc cgagaatatc aattaatgtt 3378121 gattttccgg cgccgcttgc accgataatg ccgatttttt tcttgccttt gaatgagaga 3378181 tgaatatcag acaccgaacg gccgactgac acgcctgaca gcttcagctc atcctgatcg 3378241 gaccaagctt cgagctgaag cggcgtctct tctttaaaac caggctgcga caaaatctct 3378301 tgaatggttt ttcctgcttc ctggccgttc agcgttgcat gataatcatt ccccacttcc 3378361 cgcaccggca aaaaatactc aggcgccaga ataagcgccg ttaaagcagg gccaagcaaa 3378421 atatcgccgt caatgaggcg caggcccaga aatactgcga ctgtcgccac cgacagcatc 3378481 gtgaaaaaat cgagggcgaa tgatgacaaa aacgccaccc ggagtgtgct catcgttgcc 3378541 ttgcgatacc gctcactcac atagaaaata tttttgctgt gtgacttgct caaacctagg 3378601 aaacgcaatg tctccagccc gcgaagagaa tcaacaaaat gattggaaag tctctgatag 3378661 gatttccact gacgatccgc ttttctctgc gcgacaaggc cgaggagaat cataaagatg 3378721 atcagaatcg gcatagcagc gactaaaatg atggctgatg tccgatcctg aaaaaacaca 3378781 taaatgacaa ctgccgcagg cacaatcgcc atgctgacca ttttcggcag aaacagctcc 3378841 aggtagcggc ggaactggct gatgccttcc atcgccagcg tcaccatttg ccccgtcccc 3378901 tctttctttg caaagcgggg gcctaatcgg aacagctgat caagaaaact tttcctcaaa 3378961 tctgctcctg tccgggcggc gtattgatag acgattttct gtcgcgccac cgtcatcccg 3379021 tgccgggcga taaaagcgat gaggaaaaag ccgatcaccg gtaaaaggga ggtaatgccc 3379081 ttcccgttga acagtccggt tacggcctca ctcagccact ctgcctgcat aataatggcg 3379141 gctgtctgaa tcaacgttaa acaagtaatc aaggtgagaa tccgcttcat tcctttatat 3379201 cgaaacaggt cttttcccat taataagtca taggctcctt atggctgacg cgcttccgga 3379261 agacataata gctccagatc tggctgccga tgacgaacgg caatagcgtt aatgctgcaa 3379321 ttgacatgac tttaagcgaa taatctccag aagaagcgtt agctactgtt aaatcgtatg 3379381 cgctatgaag cgagctgacc attacacgag ggaataggga aataaagatc attcccacgg 3379441 tcagcgccag accagcgcct gtcatcccaa atgtccagcc gtcttttttc ttacgaataa 3379501 atacagccgc gagcataaag cagatgacaa tcaaaacagc gagcggaatg gtaatctcgc 3379561 cgcggcgtgt aaacatgtct gtctgatacg cagaaagggc cgcgaaggca agaaccgcta 3379621 caaaaacaac acccattatc ttttgcgcca ttttccgggc gcggttttgc aaatcaccaa 3379681 tcgtacgcag cgtgataaac attaatccat gctggaagca aagaagcgtt accgtcacac 3379741 cgccaagtat agaatataca ttgatataat cagatacatg tgcgtgaatg ttcatgtcgg 3379801 catcaatcgg catcccgcgg aataatgtcg tgaacagcac accaagcaca aacggaggaa 3379861 ttagactgcc gaaaaaaacg acccagtccc aaacctttac ccattttaaa tgatccacct 3379921 tgccgcggaa ctcaaacgcg accccgcggc ccattaacgc aagcagcact atgacaaacg 3379981 gaatgtaata accgctcagc atcgttgcat accagtttgg gaatgccgcg aaaatggcgc 3380041 ctgcgccagt caaaagccac acttcattcg cgtcccagaa cggcccgatc gtgttgatca 3380101 gcactctgcg ttctaattca ttatggccaa gaaaacgggt cgccatgccg accccgaaat 3380161 caaagccttc caaaaagaag aatcctacaa acaatacagc aacgagtata aaccaaagat 3380221 catgaagaga tgccatggta tacctcctga ctaaatggat ctgttgatac aggcacatca 3380281 tgatgattat catgctccgc acctttttta atctcacgga taaacaagaa gacaagcagt 3380341 gcaccaagaa tcatgtacat cacaccgaat gcgatgattg agaataacaa ggaacccgct 3380401 gttacgttag gcgacacaga ttgagcggtt gtcattaacc ccataaccgt ccaaggctga 3380461 cgtccgattt ctgtcataat ccagcccgcg gagtttgcaa gaaacgggaa ggaaatcaac 3380521 gcgatcatga tgcgcaaata ccatttgctg ttttcaagct ttttacggcg gtttaaccaa 3380581 aggccgccta acgcagcaag aatcatgaca acacctgctc ctaccatgat gcggaagctc 3380641 cagaatgtcg ttttcactgg cggaatgtag tcgccttttc cgtatatttt ttcgtactca 3380701 gcctgaaggg ttttcatccc tttgacactt ccgctgaatt tctgataagc caagtagctc 3380761 aaggcataag gaactttgat ttcatttgag cttttttcat tttttgtatc gatcgtcgca 3380821 aaagcggtcc aagcagcagg gtcaccgctg tcttcccata ggccttcact ggcagccatt 3380881 ttcatcggct gtgattccat caagtgctca gcctgcatgt gtccgctaag gccgacgcca 3380941 agaccggcac aaagaccgac gatcattgcg agtttaaaag attgcttaaa gaacggcact 3381001 tcttttttct tcagcagttt aaaagcactc actccggcaa taaagaaagc tccagtggca 3381061 agcgcaccga aaataacgtg cgggaattca acccaaagct gagggtttgt aatcaacgcg 3381121 ccaaaatcat tcatttccgc gcggccgttt ttgatcgtaa agccgaccgg ctcctgcata 3381181 aaggagtttg ctgttaaaat ccagaaagat gacatgatcg ttccgaatga tacgagccat 3381241 atgcagagcg cgtgaatttt cttcggcagg cggtcccagc caaaaatcca taatccgata 3381301 aaaatagatt ccatgaaaaa cgccaataat gcttcaatcg caagcggagc gccaaataca 3381361 tctccgacaa aacgggagta atctgaccag ttcagtccaa actggaattc ttgcaaaatc 3381421 cccgttacaa caccgactgc gaaatttatt aagaataagt gtccccaaaa ctttgccatt 3381481 ttgagataca gctcattttt ctttacaaga taaagagtct ccatcaacgc aaccataaac 3381541 acaagcccga tagacatcgg cacaaacaag aagtgaaaca acgttgttga tgcaaattgt 3381601 atgcgggcta ataccaattc actcatgctt tctcctccat ttccggttaa aactgttaat 3381661 ttgctcacta cttcacaaat agaaccgaga ctttgatcag taattcacaa aatagacgaa 3381721 aaaaatattg ctcaatattt cacaaatgtg tcaaaaagtc atccaatatg atgcaagatt 3381781 gccagactga ccaaatgaca caatctctga ctggttcata ttaagtactt tacaacgatt 3381841 catttcaaaa ataaagccta aaatacctaa aaagtcccgc actatgtgac ggatttttgt 3381901 ctattttgtt gcttatttat gtcggctgct aggataaatg accctttatt atcgtacatc 3381961 aacacatcgt tccttgcgaa caaaatgctt gcccccgccc cagcactcga gtctcagcat 3382021 tccgtcttaa accgatttta gtcagaatgc ctcttttcat ttgaaccggt aagaggagaa 3382081 aagttgaata gtaaattttt aatatattaa taatttcaat tttttagtat acttaacata 3382141 gtgaacaatt tcactgcatc aagaataggg gaggtttttc aatgggagag cttcaaacac 3382201 acatgcaatt gcaaacggat acaattcacg aaggggttcg aaaagagaat tggtttgcga 3382261 aagccatgaa tataaaagta ggcatcatac cgcttcctgt gtatgccttg ctgtttatat 3382321 taatcactgt ttttgttatg catcacgatg taaaaagtga cattttgaca tccattgccg 3382381 tcatggcgtt tttcgggttt acctttgccc aaatcggcaa atcgataccg attgttcgtt 3382441 ctatcggcgg cccggccatc ctagctactt ttattccgtc cgctgtcgtg tactatcacc 3382501 tgctgcctaa tgatatcgtc aaatccacca cagaatttac agaaaactca aactttctat 3382561 atttgtttat cgccggtatt gtcgtcggaa gcattctcgg catgaaaaga gaaacactcg 3382621 taaaagcatt catgaaaatc tttattccgc ttattgtcgg ttctgtcaca gccgctattg 3382681 tcggactggc tgtcgggaca ttgctcggac tcggatttca gcataccctg ctgtacattg 3382741 tcattccgat catggctgga ggagtcggag aaggcgctat cccgctgtcc atcggatatt 3382801 ctgacatcat gcccatttct caaggggaag cgtttgcact tgttctgcca tcgattatgc 3382861 tgggcagctt gtgcgcgatt attctagcgg gattgctgaa ccgaatcgga aagaaaaaac 3382921 cggaatggac aggcaacggc aaagtggacc gctccgaaga agagtcccct gcgctggagg 3382981 aatctcaaag cggacagcaa atgttcaacc tttctttatt tgcgtcaggc ggtatccttg 3383041 ctgtttcttt atacttagtc ggcatgctcg ctcacgattt tttcggtttt ccggcacccg 3383101 ttgccatgct gttactggct gttctaatca agctgttcag attggtgcct gcctcaattg 3383161 aaaatggcgc gtttggagtg tcccgcttct tttcaacagc tgtgacctac ccgcttctct 3383221 ttgcgattgg ggtatccatg acgccgtggg acaagcttgt cgccgctttt aacctcagca 3383281 atattatcac gattctgtct gtcgttgtga ccatgatggc cgttggcttc ttcactggaa 3383341 aatggctgaa catgtatccg attgaaaccg ccattattaa tgcatgccat tctgggcaag 3383401 gcggcacggg tgacgttgcc attttaagcg ccgctgaaag gcttgagcta atgcctttcg 3383461 cccaggtgtc tacccgcatc gggggcgcga ttacagtatc cttaacctta ttgctgctgc 3383521 accagtttta ttgatccccg caagcaagtt cttcgtcaaa cgaaagagct tgcttttttg 3383581 catgtccatg tttttgcaag ttcccatccc atgctatagt aatagttgga aatactagat 3383641 agaaaggaat ctggcatgcc tatgggaact catctatttc tctttatgct tctcgggctg 3383701 ggattttatt tgatatcagc cctagctgca aaactcattc cggccataga cttctggatt 3383761 gatattgttc tatgggtcgg cgctgcggct tacatcttct ctcatctctc attcatggac 3383821 ggcattgtct cactcgcgac aatgttctac tgctattgga ccgcaatgga tctcattgtt 3383881 tcagagcgtg tggaaaaacc ttcgggagac tggcaggaaa tcgagcttgc caaaaacaaa 3383941 acacgcctcc tgtcagacat tacgctgacc gccattgtgt ttgcaggggc tgtcattttt 3384001 ttcatctatg gacctgacac aagccctctc aaatatgtga tccttctcgg aatgatctcc 3384061 ggcggagggg cacttgtgaa gcgaatactg aatgttttta gcgtaaaggt tttttattca 3384121 gcagccttag aaaaattgca tatcagctca cactatgaaa cccgtacata cccgctttcc 3384181 gatttgaaga acattcagct tgaatcaaca gcagatctct taaagctcca tccgcttctg 3384241 acgatgtatt catcccgttt agatttgaca acaagctttc agcaagtcat taaactgtct 3384301 cttcccggcg aaacactgtt tctgacggtg aaggaaccgc aaaaatggaa aacaattctt 3384361 caggaataca cagatgcaga aaacaatgtg gacaatgtga tttctgtttt gccgttttat 3384421 catcgaaaaa atgtgaagcg gctgctcggt aagctttatt ttgccgccag cgtaaaaggg 3384481 gtatccgctt acgccttatt ggtgctcgcg ttatacgcat tacacgcctc tccatgggtc 3384541 atggctgttg ccgtaatcct atattgggta ttcaacatgt atatgtcaga ccgtgtgttg 3384601 cgggcggcga tggacgccaa gtcttgtcat catccgcatg tacaggccgc ggccgataag 3384661 attttcagat cggccggcat ttcccatgtc cgcatatacg aaacggagag tgatgattac 3384721 aacggaatgg cagtaggcat gaatgtcggg aggtcaatgg tcatcctgac aagcgccaca 3384781 ctaacacttc cacagcgtgt cattgaaggc attctggccc atgaggcgat tcatatcaaa 3384841 aaacgtgacg ttctgtcatc acagcttttg cgttttctat atcttggagc tgtcgtgggg 3384901 attttcctct tgtttgagca gcatatcacc catcccgagg cccacaaaat tgcgctttgg 3384961 gctttcatta tggcaatcat tatcctattc cagctctatc aatccttttg ttcacaatgg 3385021 atggaggtgc gtgctgacaa ccttggcgca tcattgctgg acggcggtta caaacaaatg 3385081 gctgaagcct tgagaatctt ggcggttcgg caagatgagg atatacagaa acaaagtgcc 3385141 tatagctctg aagcaggtga agacgagctt caaattgatt ctctcacccg tgataaaagc 3385201 tggtttttca gattgattga ttttcagttc gctcctcatc ctcctatgta ttggcgtgtc 3385261 ggcactttat tgtcaaacaa aggacatggg gtgctaaagc gctggctcag agaccgactg 3385321 aaagaatcga tcactttgaa atgaaaccgg tcagcgtttc atccgtataa cagatatggt 3385381 gaaaaaaggg agtgacgcga agtgattgtg atcatcttat tgtttatatc tattattgtt 3385441 tttctttcag tcattcagcc gcagccctcg aaaaacaaaa gccgccagca ggcggacagc 3385501 gggtatttcg gttattcaga tcatagctca caccatgatg gatgcagcag tgacggaggt 3385561 ttcagcgatt ccggctgtgg cggcggaggg ggcggcgatt aaacgccgcc tttttttatt 3385621 tcattgattc gatgtacgca ccaaaagccg agcctgacat gcctggggac acgcgcacac 3385681 gatggagggc atacattccc tggtctctcg aagccgcgcc cggttctgtc gtcacgccca 3385741 tttgatagcc tgttttttca gcggccttca gcgtctcctc attgtagcgc cctaccggat 3385801 agctgatgat ggtggtttgc tgatgaaaca tgttgtcgaa cagctttttc gaatcagcca 3385861 tctcactttg ctgctgttga ggcgttaatc cgttcagctc aaggtggtca atcgtatggc 3385921 tttcaatcga tatgccgtgc tgtgccattt ccttcatttg ttcctctgtc agatggtgct 3385981 tatgtccgat cgatttgccg atcataaaaa tcgttgcctt catcccgtac tttttcagca 3386041 ccggatacgc atcttgataa ttgtcggtgt acccgtcatc aaatgtgatc agcacgcact 3386101 tctcactcgg ttttttatcc tgcgtcagca tgagagatgc ctctttcggc gttaatgtct 3386161 gatagccgtt atcatgaagc cacttcatat gcgcctcgaa ttctttcttt ggcacacgga 3386221 ggctgtttcc tgaagaaatg ctgtggtaca tcaaaatcgg cagctttgcc ggtttctctg 3386281 ttttgatcca tgcggatgta tcgtcttctt ttttctgaac ttgtactgcc tttttttccg 3386341 gtttcttttg ttccgctttt ggcatcggct gctctgcatt cgcctcttga tcagcacaag 3386401 ccgcaagagc caaacagctg cccaaaagaa agatgcttaa aaacaatcgt ttcatcgttc 3386461 tcctgctttc tgtctatttc ttcctccttt ttcatcggtt tgattctgag attttcaata 3386521 gcaaaaaacc ggacatgtct ccatgtccgg tttttttgat cttatcggat tctcacttct 3386581 gtctcactgt caaagaaatg gcctttattc atatcaaatg caaccgtcag ctcatcgccc 3386641 gattgaatat cgaggcgggc gtcgatccgc gcaataaagt cttggttgtc tatctgcgaa 3386701 taaatcataa tttcagaacc gagcagctct gcaacattaa ttttcgcctt aatcgaagag 3386761 ttcttatatg attccacgac aatcaattca tcatgtatat cctcaggacg gatgccgaag 3386821 atgacctctt tgccgatgta gcctttttca cgcagcactt tcatttttcc ttccgggacg 3386881 gttaatgccg cagaaccgat tttgattaag ccatccgtga gctttccttt gaaaaaattc 3386941 atcgccggtg atccgataaa cccgccgaca aagacgtttt cagggaattc atatacatcc 3387001 ttcggcgtcc cgatctgctg aattttccca tctttcatga ctacaatccg tgtcgccatt 3387061 gtcagcgctt ctgtctggtc atgcgtcaca taaatcgttg tagtctgcaa tctctggtgg 3387121 agcttaatga tttccgcccg catttgcacc ctcagcttcg cgtccaggtt tgacaaaggc 3387181 tcatccatca ggaacacctt tgcatcccgc acgattgccc ggcccagcgc aacccgctgt 3387241 ctctgtccgc ctgacagcgc tttcggttta cggtgcaaat attcctcaag cccgagaatt 3387301 ttagcggctt cttcgactct ttttttgatt tcaggcttcg gcattttccg aagcttgagc 3387361 ccgaacgcga tattatcgta gaccgtcata tgcggataaa gcgcgtagtt ctgaaatacc 3387421 atcgcgatat ccctgtcctt tggcgctaca tcattgaccc gttttccttc aatataaaaa 3387481 tcacctttcg aaatttcttc aagtcctgcg accattcgca gcgtcgttga tttcccgcag 3387541 ccggacgggc cgacgaatac gataaattcc ttatcggcaa tatgaaggtt aaagtcatca 3387601 accgccggtt ccttctgatc ataaaattta taaatgtgct ccatccgcaa ttcagccatc 3387661 taacatcccc ctttgttatt gtaaacgctt tcttatattg agtgtaacag caattccctc 3387721 tcgctaaaat gggcagcgtt cataaaatca cccagccatt tttcgtgcat atttccaatt 3387781 tattctgaac tttcattttg caggcagata aaataggcaa gaagcgcgcc tttgtacgat 3387841 ttgatatcta tccctgaccg ctcaataaat ttatcaatcc gatattgcag gctgttgcga 3387901 tgcagatgca gctttttcgc tgttaatgtg acgtttgagt tgttttcaat aaacagctta 3387961 atggtcttcc ttagctcaga ttcacttcca aataaaagct cagcttcttc agagagcagt 3388021 gtttccagtt tttctttttc tgtttctaat aatagaaaag gaaagatcat ctcaaaggtc 3388081 acactctgca cctgaggcag ccgtttttca gcaaacagga aatacgcctg ttcacgagcg 3388141 taatgttttc gcagacactc atccggctcg taaaatcttc cggcgtaaaa acggacactg 3388201 aagtagaaat cactttcaag aaccttagcg agcgattcca gttcgtcctt ctccgccgcc 3388261 gcttcacttt cctgctcgac aatcacacct ctgtcctcat ggatccacac aatcacaaaa 3388321 gacaccggcc aaaaatggcg aaccgcttcc gtaaaggacg tcctttctat tttgccgaat 3388381 aaatgaaagt gaacaaatct cgtccgtttc tttatatacg ccggcaattc ccctctggaa 3388441 aaaaggaacg aaaaccactt gttttcctca ggtgatttca tagacagttg attgccctca 3388501 tccgcaggcg tcaaaaatga ctgcagcacc aatacttctt tttcactgat ctctgttttc 3388561 ggaatggaga tatatctctg attgctctca tcaaaaaaac atagacagcc ttcccttatg 3388621 caaagctcct cagacacaat cgaaccggga taaatagcca gcagcgattt catagagtct 3388681 cctctcttat gtaaggatct gtatattcag tataaggcga aacacacatg ttctccacta 3388741 aaaaagagta tatccggtat agatagacga gaaactgaaa gggaaacctc attcgtttac 3388801 atattggctt cagcggaaat agaagaagac atgcaggacc aaaggagggt catcttatga 3388861 gtttcgaaac gttaaacaaa agttttatca acggaaaatg gactggggga gaaagcggac 3388921 gtacggagga cattttgaat ccgtatgacc agtctgtgat cacaacagca tctttggcaa 3388981 cgggcaaaca gcttgaggat gcgtttgaca ttgcacagaa agcccaaaaa gagtgggcca 3389041 agagcacgac ggaagaccga aaagccgtgc tgcaaaaagc gcgcggctat ttacacgaaa 3389101 accgtgatga catcattatg atgatcgccc gcgaaactgg cggaacgatc attaaatcaa 3389161 caatcgagct ggaacaaacg attgcgattt tagatgaagc catgacgtat actggtgaat 3389221 taggcggcgt caaagaggtg ccatccgaca ttgaagggaa aaccaataag atttaccgcc 3389281 ttccgctagg tgtcatttca tcgatttctc catttaattt cccaatgaat ctatccatga 3389341 gatccattgc gcccgcaatt gcgctgggta acagcgttgt tcacaagcct gatatccaaa 3389401 ctgctatttc cggcgggacc atcattgcga aagcgtttga acacgccggt cttcctgccg 3389461 gtgtccttaa cgtcatgctg acggatgtaa aggaaatcgg ggacggcatg ctcaccaatc 3389521 caatcccgag attaatcagc tttacagggt caacagcagt cgggcgccac atcggtgaaa 3389581 tcgccggtcg cgccttcaaa cgaatggcac ttgagctcgg cggcaacaat ccatttgccg 3389641 ttctttcaga tgcggatgtc gatcgtgctg tggatgccgc gattttcgga aaatttattc 3389701 accagggaca aatctgtatg attatcaaca ggatcatcgt tcatcaagat gtatacgatg 3389761 agtttgtaga aaaattcacc gcccgtgtca aacagcttcc gtacggcgat caaaccgatc 3389821 cgaaaaccgt tgtcggcccg ctgatcaacg agcgccaaat cgagaaagcg ctggagatca 3389881 ttgagcaggc aaagacagac ggcattgagc ttgcggttga aggaaaacgc gtcggaaacg 3389941 tgctgacgcc gtacgtcttt gtcggtgcgg acaacaacag caaaattgcc caaacggagc 3390001 tgtttgcccc aatcgcaacc attattaaag ctggcagcga ccaggaagcg attgacatgg 3390061 caaatgatac tgaatacggc ctcagctctg cggttttcac ttctgattta gaaaaaggcg 3390121 aaaagttcgc cctgcaaatt gacagcggca tgacccatgt caacgaccag tccgtcaatg 3390181 attcgccgaa tattgccttt ggcggaaaca aagcaagcgg tgtcggccgt ttcggcaatc 3390241 cgtgggtcgt cgaggaattt accgtgacga aatggatttc gatacagaag caataccgca 3390301 aatatccgtt ctaaatgaaa aaatccctct gtttcaagta cagagggatt tttctttatt 3390361 tagatatatc cacaaaccct tcgccaaaca catcgcgtac gtcatgtacg atcacaaacg 3390421 cttttttgtc gcagcttcta atgatttttt tcagcataga cagctcctgt ttgttaatga 3390481 cgatatacaa aatctctttt gactggcccg tataatttcc cttccctgat aaaatcgtca 3390541 cgccccgatc catcaaggta tttacctgct ctgcaatctc actcttattt tctgaaatga 3390601 ccgtaatggc ttttttcgta ttcaaacctt caataatgaa gtccatcact ttggtaccga 3390661 tatacagcat cacgatcgta aacatcattt tttctgcacc aataataaaa taagagctaa 3390721 atactacgat taaatcaaaa aacaagagtg catagctgat attccagtct aaatatttat 3390781 tagcaattct ggccagaatc gcggaaccgg ccgtcgtccc gccgacccgg ataatcatgc 3390841 cgatcccgac tccggcaaat acacctgcga aaatcgtatt aatgatcaat tcatcagacg 3390901 gaatgctcca cccatgtgtc agatgaagaa aaagcgaatt tgccgcaacc gcaatgatcg 3390961 tataaaccgt tgtttttcca tcaagaaact tgtagccgat taaaagcaaa aacgcattta 3391021 agataaagtt cgtgacacca ggagaccatt gaaacagata atacaaaatc agcgtaatcc 3391081 cagtgactcc gccttcccca agatcattgg gaatcgcaaa taaattaacc gcaagcgcga 3391141 agaaaaaagc gccaatcaca agcataagta catccagcat tctctttttc atcacgaaaa 3391201 cactcctttt cattgttctg ttctagcaaa taaaaaaacc caggagaacg ctctcgaaaa 3391261 agagcagaaa ctcctgggct tttatcccac cgtgtcataa cagccaagct gctatgtgtt 3391321 ttctctcggt cacagtccaa tttgcattgc ggaaccctag aaaaccactg tttttatcat 3391381 atccttttca ctttccaata ttagcattat aagggacggt tcgaattggt tcaaggggta 3391441 tttgcggagt tttcatcaga taagctggaa aaaaatacga tttatctatt aaaaaagaac 3391501 agatataacc gataagaaaa aaagcatata ttttacaagc gaatgtaact ataaatgata 3391561 ataattataa gaaattcata attttatatt gactaagaga aataatatag gcattatagt 3391621 acatatgttt cgtacatttt attacatagg aggaaatata atggcaggaa aactagtacc 3391681 ctgtaaagct tgcggtcaag aaattgcaaa gggtgtaaaa aaatgtccta actgcggtaa 3391741 ggatcaacgt aactttttta tgcgacataa aatcattacg tttattctcg cagttgttgt 3391801 catcattatt atcggtaata tgattggcgg cggaggcggc tcagaagcca cttccaaaac 3391861 atcaagcagc agcaaagcag aaactgaaaa aacatacaat atcggtgata ccgtaaaaac 3391921 tgaaaaaact gaagtgacgg ttacgaaggt agaggacaga gatactgtcg gtactcaata 3391981 tgttgaaaag aaagcatctg agggaggtac aattgtagct gttcaatata caattaaaaa 3392041 cgtatctaaa aagccgatta gctctttttc aattccaact gttaaattag ttgatgctga 3392101 tggtacttct tatgattctg atattgatgc ttctgtaaac tatgcaactg agacaaaagt 3392161 tgataactct aaaattttga gtgatctaaa tcctaatatt aaagtaacag gtgtaaaagc 3392221 atttgaagtt gacaaggaag cttatgcaaa aggcacttgg aaactaaaat tcagtaatga 3392281 tgttattgtg aaaatcaaat aacagctaac aagggtgcct gtttaggcac ccttgttctt 3392341 taaaaaaggc cttctcaatt gagaaggcct ccattcttat tccgcactct tatacccatt 3392401 cacattagaa gactgccatc tccaggaatc agcacacatt tcctcaaggc cgcgtttcgc 3392461 ttcccagcct agttctcgct tggctttcgc aggatctgca aagcatgtgg cgatgtctcc 3392521 cggacggcgg tccgcaaaac ggtatggaac ctctttccct gacacttttt caaaggcttt 3392581 gaccatttcc agcacgctgt agcctgtgcc tgttccaagg ttgtatgcat cggctcctgt 3392641 agagttcaat actttttcca gcgccttgac gtggccttct gcgagatcaa cgacgtgaat 3392701 ataatcgcgt acgcctgtcc cgtcttttgt cggatagtca tttccgaata cgcttaattg 3392761 ctcgagcttc ccgactgcta cctgtgccac atacggcata aggttatttg ggattccgtt 3392821 cgggtcttca ccgatccgtc cgcttggatg cgcgccgaac gggttaaagt aacgaagcag 3392881 cgcaacgctc cactcattgt cggctgtatg caaatcacgc aatatttgtt caagcatgag 3392941 cttcgtctgc ccataaggat ttgtcgcgcc taatggaaag tcttccgtaa tcggcgatgt 3393001 ttccggaacg ccgtatactg tcgcagatga actgaatacg attttcttga cgccgtattt 3393061 ctccatggcc tcgcataaaa taaacgttcc tgtcaaattg ttatgataat atttgagggg 3393121 aatcgccaca gattcgccga ctgcttttaa ccctgcaaaa tgaatcacag cttcgatttc 3393181 attttcagca aaaacggaat ctaccgcttc ccggtccaat aaatccgctt cgtagaacgt 3393241 taaatctttt cctgtaatct ccttgacacg gttcagcgct tcagctgaac tgttggacag 3393301 attatcaaga acaacaatct cgtagccgct gttcaatagt tcaacacatg tgtggctgcc 3393361 aatgtaaccg gcaccgccag taacaagtat tgccatgatg taaaccctcc taaaaaatga 3393421 cctgttttca ttatatagtg tttagaaccg gtccacatcc atttttaaga agtttaatcg 3393481 tttattaata gttttttcat attttttagc ttaaaccctt gccagcaatt cgatagaggt 3393541 ttcagcaaga atgtgctctt tcatttcttg atagagctca ttcaagtaaa agcccggctg 3393601 aagattcagc tcagcatcta aagcatagac cgtcaatgta tacgcatgat ccttgtcagg 3393661 cggtgtcggc ccgcaatact ggtgaatcac ctttggatcg ttgcttcccg caagcggtga 3393721 agcaaagctg ttttgccctt gtatcatcaa gtcctgtctt tcctcactcg catgttcagg 3393781 aagctctccg atgtaagccg gaatattagc cgctgtccag tgaatccagc tgaatccgca 3393841 tacgggaatg gcgtcatgat cgatgaaagt aagtgcgagc gtctttgctc cggacgggat 3393901 gtcatcaaaa tgaattggaa aggatacaaa tgggtttcct tctctcttat atttttcatc 3393961 cgcgtatttt gaatacttgt catgtaaata tggatttgct tctacgtata tgttcatatg 3394021 aatccctctc tctattttct cgttctatag gtatactaaa cgaatcgatg tataatcagt 3394081 gataaacaaa tacgcatgta aacgtaacaa tttgttatgg ataacttgca gtgaaggaga 3394141 tatttcatgg atttaaaatg gctgcaaacc tttattgccg cagcggaatc agagagcttc 3394201 agggaggcgg ctgagcatct gtatctcaca cagcctgccg tttctcagca tatgaggaaa 3394261 ttggaagatg aactggacat gaggttgttt ttgcatagcg gaagacgagt cgtactgact 3394321 gacgaaggca ggctcttttt gccttatgcc aaagaaatga tccatgttta ccaagctgga 3394381 aagcagaaag tcagtcaatg gaaacagggg tacagccgat cactcacgct ggccgtacac 3394441 ccctacattg cgtcctatat cttgcctcgc tttctgccag cctatatcca aaaacatccg 3394501 catgtcgagc tttcaactca tgtggctgga tctgacgcta ttaaacaagc ggtggaacac 3394561 aatgaagctg atattggttt gtcgcggaaa gacccgaaca ccaacactct ttattatcag 3394621 catatatgcg aaggtacgct ttgtctggcg gctcctttcc aagaaagcag accggatgct 3394681 gcatccgtct taacccgcta tcggctgcta acgcatgatc atccgtcata tggggatgcc 3394741 tttttagata acatccgatc acattacccg tatcttcaaa tgatggctgt cgggcagacg 3394801 gatacggctg tccacatgat gaaagcggga atgggggcat ctttcctccc tacctacatt 3394861 atcaaacagg aagaagccga aaaaaagctg atggctgtca gcacgcctgc acatctagaa 3394921 ttgcctgcgt cccaaacgtt tatgatgtgg aaaagaaaca gcgaagacat tcagcatttt 3394981 cacgccatgt tacatgactt tatgcagcgc gaacaagtat agagctgaaa aatcaatctg 3395041 ccggttgacg tttttctttc ctattttcgc tatgcttaat gcagaaagga tttgatgaca 3395101 tggcgatgag cccttatatt tttattgtat tgattcttat tattttatcg atgtatcgag 3395161 aaagaacggt aaagcccggg aagttgctga tcattccact gttgctctta tggggcgtat 3395221 ctgcatcgtt tcagccggcg tattttcatt ccgtattaca tgtggcgatc agcggcattt 3395281 tattactgat cgggctggcc tgcgggtttg gcattgggaa gatggtaaat gtacggattc 3395341 acccggaaac cggaaaggtc acttcacgcg gctcacttgg gagtgttatc ctcattctag 3395401 tgatactttc tttgcgcatg gccgcgagaa catggctgcc tgagagcaac gagatgttta 3395461 ttgccattat tcattctatg ttcttcgttc ccctcggcac catcacagcc cgcaacatca 3395521 tgctttacaa agcatacaga cgactgaccg ctggcaaagt atccattcaa taaccgaaag 3395581 aaggaccagc atgaacggac aaactccggc tcggcactac tacaagaagc ttgtgccgag 3395641 ccttattctc attttgaatt gcatacaatt tttatctcat ccaactaagg ctgatcccat 3395701 tttgttagca tttgtatttg cggtatactt agcattcatt tggatcattc cctatgtggc 3395761 atccactgct gttagtttga gcatattcat cggactctgg ctcctgaccg atttcttttg 3395821 ggctgtttcc ggccaagagc agggtgccgc ctattttttg attgtatttt taatgatata 3395881 tgccgccttt agactccctt cacggctatc cttgatcttc acagcatgtt taattggagg 3395941 caacatatta ctcctatcct cacaaggggg aagcttgaat accatcatca gcaacatctc 3396001 gatcatgctc ggtctgtacg tcctcttctc ctccatgcgt ttcagacgag aagcgagaag 3396061 ggaggctgaa cggaatcatg ctgaattggc aaaaatgcat gtgcagctgg agcatgctca 3396121 taaagaactc cagaaagcgc atgcagagct gcaggaggct tctgttcttt cattaaggta 3396181 cgcggtcctt gaggaacgta caagaattgc ccgcgacatt catgacagca tcggtcacga 3396241 gctgacttct gtgattgttc agcttcaatc ccttccctat atccttaaaa gcagcaagga 3396301 ggattcagaa aaagtcattc aaaatgtact gagtgtcgcc agggagtgtc ttcaagaagt 3396361 gcggtctgtt gttcaccaaa tgggccgtag tgaatcgatg gtggggctta ccgctttgcg 3396421 ggggctcatt catcaagtgg aggaacggag cggcttgcac gtttctttag atactgccgg 3396481 actgtcagaa gagtcttggc ctccaaacgt gagcgaaacg atctaccgca tcttgcagga 3396541 agcgctgacc aatatcattc gtcacgctga cgcttctcat gcggcggccg tcatttctaa 3396601 tgacaagtcc catctctatg tcacaatcac cgacgacgga caattcaccg gcagccttac 3396661 ttatggattt ggcctgacag gaatgaaaga gcgcgcagaa aaagcaggcg gttcccttac 3396721 tttcagtgcc gtacagccga gcggcctgaa aattgagctg tcattgccgc tcatgacaac 3396781 gaataaggag caaaaagatg aacaaagata aaatacgcgt agcgcttgcc gatgatcagc 3396841 cgcttgtgcg tgaaggcttc cgctacgtca tcaacgcaca gacggatatg acggtttctg 3396901 gcgaggccgg cgacggtcac gatattatag cactcgcaaa acaaacaaaa cccgatgtca 3396961 tcctcatgga tgtccagatg ccgcgttgct caggcatcga agcggcgaaa gacattatgt 3397021 ccgcacttcc aaatacaaag atagtcattt taaccacctt tgacacggaa gaatacgtat 3397081 ttgaaggcat ccgtgcgggc gcagtcggct atctgctgaa ggatacactt cctgaggagt 3397141 tgatagatgc gattcgcgct gcggccagag gcgaggcgat tttccgtaca gtcacagctg 3397201 ctaaaatcat cagtgagaca tttcgggcga aacagcaaac tcatgccgaa gaactggcag 3397261 agccgttcac caaaagagag cttgaggttc ttcagcaaat ggcctacgga ctgagaaatg 3397321 aggatattgc tgaaaagctt ttcgtcagtg aaagcactgt gaaaacccac gtgcaccgca 3397381 tcctgcaaaa atgcaatgcc caagaccgga cacaggcagt cgtttttgcc attcgaaacg 3397441 gtattgtgca atagaaatct ctcatcccgc catgctaaaa taagacaaag gagatgattg 3397501 gaaatgaaag aagaaatcat tgaacggttt actacatatg taaaagtcga tacacagtcc 3397561 gatgaatccg ttgacacttg tccttccaca cccggccaat tgacattagg aaacatgcta 3397621 gttgatgaat tgaagtccat cggcatgcag gatgcagcca ttgatgaaaa cggctatgtc 3397681 atggcaactc ttccctccaa tactgaaaaa gacgtgccga caatcggctt tctcgctcac 3397741 gtcgacaccg ctacagactt taccggcaaa aatgtgaatc cgcaaatcat cgaaagctat 3397801 gatggaaaag acatcgttct taacgaacag ctgcaggtca ccctgtcacc tgatcaattc 3397861 cctgagctgt ccggctataa gggccataca ctcatcacca cagacggcac cacccttctc 3397921 ggcgcagaca ataaggccgg tatcgctgaa atcatgacag ccatggatta cctcatcaaa 3397981 caccctgaaa tcaagcacgg cacaatcaga gtcgccttta cgcctgatga agaaatcgga 3398041 agagggccgc acaaatttga tgtgaaacgg ttcaatgcat cctttgccta cacggttgac 3398101 ggcgggccgc tcggcgagct tgaatatgaa agcttcaatg ccgctgccgc aaaaattacg 3398161 attaaaggca acaacgtaca tcccggaaca gctaaaggaa aaatgatcaa ctctgcgaaa 3398221 atcgcgatga agctgaacag cctgctgccg gcagacgaag cgcctgaata tacggaaggt 3398281 tatgaaggct tctaccacct gctgtcgatt caaggagacg tagaggaaac aaagctccac 3398341 tacattatca gagactttga caaagagaat ttccaaaaca gaaaagaaac aatgaagcgt 3398401 gccgttgaag aacttcaaaa cgaatacggg caagaccgga ttctgctgga tatgaacgac 3398461 caatactaca acatgagaga gaaaattgaa cctgtcatcg aaatcgtcaa cattgccaag 3398521 caagcgatgg aaaacctcgg catcgaaccg aagatttccc ccatccgcgg cggaaccgac 3398581 ggatcacagc tgtcctacat ggggcttccg acgccaaaca tctttacagg cggggaaaac 3398641 ttccacggca aatttgaata catctcagtt gacaacatgg tcaaagccgt aaatgtcatc 3398701 gttgagattg caaagcagtt tgaagcgcaa gcataacgcc aaaagccagt ccaaaaaagg 3398761 actggctttt ttgtgtgaaa atgaaacatt ttaaacacgt cctccgtaaa acaagtatca 3398821 acaaatgagg aggaaaaaca atgacaaaac atgcaatcgc tgccaagagt ctcttgaaaa 3398881 aatggatcat ttccaggccg cttaacatga aaaagaaatc cagcccattt caaaaaatca 3398941 gaaaaatgtt caaacgcttc ttcaaataaa acatcaaatc ccctaaatac aatccgtatt 3399001 cacccgtacc gcccaaatgc tccgtaattt gggttttttg tgttcaattc cgcaaaatag 3399061 ggtataaacc aaacaagcaa gaaaacagca cccaaaaaca ggtaattcga attacgtaaa 3399121 cttaggttaa aagttatata aaggaattta ttttatcgtc gatagtaact atagaaccaa 3399181 tcatcaacaa gagcaaacag cgtaattcaa gactattttc aggtcatcag gtaatactgt 3399241 tttagaggga cagtttcttg ttatttattg atttagaatt ttttgaatac tttttggcat 3399301 tttatccgta caatagagag taccaaaact ttttttggga ggtatgtaat atgatcctat 3399361 ttattatcat cgcattatgc ggctatcttc ttttttcttt cagcaaggac aatcgccgca 3399421 aaccgcaaaa gacaagccct ctgccagcag ccgcacctca tcacaacaac ctaatcgacc 3399481 ttgacgccat ccgccaaaaa cgccggatgc atctttccta attctatatt tcaaacgaaa 3399541 aggctgctga atcacgcagc cttttaaaat tgttttgatt tagagcctga aaccttttcg 3399601 ccacctatcc gtaatttcat acaaggcaaa cccaaaggag acttcagcaa tgatcgagtt 3399661 atttatgaaa caaaaaatgt tctcatttaa agatgcattt cacatttatg accgggatga 3399721 acaagaaaca ttcaaggtgg aggggcgttt tttctcgtta ggagactcat tacaaatgac 3399781 agactcatct gggaaaacgc tcgtttccat agaacaaaaa ctaatgtctt tattgccgcg 3399841 ctatgagatt tcaattggcg ggaaaacagt ttgtgaggta acgaagaaag taacgttttc 3399901 caaaccgaaa tttgtgattt ccgggcttaa ctgggaaata gatggtgatt tatggaggga 3399961 tgaattccaa ctgacggacg gggaaaatgt ccggatgtca gtgagcaaaa agtggctcag 3400021 ttggggtgat tcctatcact tgcagattgc atacgaggaa gatgttctga tttgcactgc 3400081 catcgctatc gtgcttgata tggttttata taacgatgaa gatgaaagta ttttctaaaa 3400141 agcattgaca attgatccaa aagtaataat attaagataa ttgaaatctg aatatgaagt 3400201 tgtaccttat caagagaggt ggagggactg gccctatgat acccggcaac cgctgtttca 3400261 aacagaatgg tgctaaatcc ttaagaacat tgcgttcttg cagatgaggc ggagatttga 3400321 tcgttcaagc tcttccttac acaaaggaag agctttttac atgcttaata tttcagaaaa 3400381 gaggcgaata acatggctca acaaacgaat gttgcaggac aaaaaacaga aaaacaacgc 3400441 aaagcacctt tccgcgccga tcatgtcggc agcttgcttc gttccgttcc ggtaaaggaa 3400501 gcccggcaaa aaaaagcggc tggtgagatg acagcggaac agcttcgtga tatcgaaaat 3400561 caagagatca cccgcatcgt ggaaaaacaa aaagaaatcg gtctcgatgt ggtaacagac 3400621 ggggaattcc ggcgttcctg gtggcattat gacttcctgg aagggcttga cggtgtggaa 3400681 ccgttcatcc cggctgaggg gattcagttc cataacacaa aaacgaaagc gcgcagcatc 3400741 aaagtgacgg gaaaactcga ttttacgagc cacccagcgc tcggtgatta tcaattttta 3400801 catgagattg ccggtaacgc gacgccaaaa ttgaccattc ccagtccaaa tatgctgttt 3400861 tttggcgaaa aggcggataa agggatttat gacgatcaag aggaatactt tcatgatatg 3400921 gcccaagcgt acaaaaaagc aatcaaagcc ttctatgatg ctggctgccg ttatctccag 3400981 cttgatgata cgtcatggtc tctcttcttt gaggacaaag gcagagaggt tgtccgggcg 3401041 ctcggcggtg atccagaaac attgccagcc atatttgcca aaacaattaa cgatgccgtc 3401101 gcagaccggc ctgacgattt aacgatcaca atgcacattt gccgcggcaa cttccgctca 3401161 acctgggcgg catcaggagg gtacgacgct gtagcggaaa cgattttgga cggcttaaac 3401221 cttgacggcc ttttcttgga atacgatgat gaccgctccg gaaactttga tccgctccgt 3401281 tttgtgaagc gcaaggatct gcaaattgtg ctcggcttga tcacatcgaa atacggcgag 3401341 cttgaaaatc ctgaggatgt gaaacgccgt atcaatgaag ccgcgcgttt tgtcagcttg 3401401 gaccagctat gcctgagccc gcagtgcggt ttcgcctcta cagaagaagg caaccttctg 3401461 acagaggagc agcaatgggc aaagctgcgc catgtcatcg acattgccaa cgatgtgtgg 3401521 agataatcta tcattgacag aaatagaaaa tgtgtgaata atagatacta tcagaaaatt 3401581 taataaaaag gttttcctta tcaagagagg tggagggact ggccctgcga tacccggcaa 3401641 ccgctgttta acagaatggt gctaaatcct ttagagcaat gattgctctt gaagataagg 3401701 ttgagattgt cacgcaagct cttccttatc caaaggaaga gcttttttat atttgaatgg 3401761 aaagaaggaa tggacaacat gtcacaacaa acaacacccg cagaacaaaa atcacttcaa 3401821 agaaaaaaac cgccgtttcg cgcggatcaa gtcggaagcc tgctaagatc tgagcccgtc 3401881 aaaaaagcgc ggctgcaaaa agcggccggc gaaatgaccg ctgagcagct tcgccaaatt 3401941 gaaaacgacg aaatcatccg cattgtggaa aaacagaagg aaaccggcct gaacgtcgtg 3402001 acagacggtg aattccgcag agcatggtgg cactttgatt tcctggaaaa cttagatggc 3402061 gttgagccgt ttactcctga gcaaggcatt caattccata acgtacagac aaaagcacgc 3402121 ggcattaaag tcacaggcga tatcgacttt tcaactcacc caatgcttga agattactca 3402181 tttctccata gcattgccgg tgacgcgacg ccaaagatga cgattccaag tccgaatatg 3402241 ctgtttttcc gcggaaaact ggaaaaggat gaatacaaaa acgattatca acttttccag 3402301 cacgatgtat ccaaagcata taaaaaagcg attcaagcgt tttatgacag aggctgccgc 3402361 tacctccagc ttgatgatac agcgtgggcc gttttcttat cagaaaaagg cttaaaacaa 3402421 atcgaagcgt tcggaacaac gcctgacgag cttcgccagc tgtttgcgaa atccattaac 3402481 gacgcgattg cagaccgccc ggatgacttg acggtaacca tgcatatttg ccgcggcaac 3402541 ttccagtcca cttggacagc ggaaggcggc tatgacgcag cagccgaaac catttttgac 3402601 ggcttgaatc ttgacggact tttcttagag tatgatgatt cacgctcagg cggatttgag 3402661 ccgctccgtt acgtaaaacg gtctgatctt cagcttgttc ttggcttagt gacatctaaa 3402721 ttcggtgagc ttgaaaatcc ggatgacgtg aaacgccgta tcgaagaagc gtcccgttat 3402781 gtaagcttag accagctttg cctcagccct caatgcggat tcgcttcaac tgaggaaggc 3402841 aacaagctga ctgaagaaca gcaatgggcg aagctccgcc atgtggttga gatcgctaat 3402901 gatgtttgga aataagcaaa gaaaaaaaca cacttgattc cctagcggag caagtgtgtt 3402961 ttttatgtca ttgtgcggtg tagcccccat caaggacgac agcctgccca gtgacgccct 3403021 tcgccttctc gcttgccaaa aacacggcat aatccgcaat ttccttgacg gaaagcagtc 3403081 gcttttgcgg cacaagcgga aaaatgactt gttcaagtac agagtcgtaa gggacatttc 3403141 tagttttcga tagatcgcta agctgattgc gtacaagctg ggtatcgaca taacccggac 3403201 agagcgcatt gactgttatg ccgtggggcg cgccttccag cgcccctact tttgtgagtc 3403261 caatgacgcc gtgcttggcg ctattataag cggatttccc tgcaaagccc actaatccat 3403321 taacagacgc aatattaatg attctgccaa actgctgttt tttcatgatc ggaaaaacat 3403381 gcttcattgc aataaaggga gccgtcagca tgaccttgat cagctgttca aaggtgtctg 3403441 tcggaaactc ttcaatcgga gcgacgtgct gaataccggc attgttcacc agaatatcca 3403501 agcggccgta ttgtttttgg atgacgttca ccgtatcagc aacttgcgct tcctttgtca 3403561 catcatacgg aatggccgcc gcgtcaaagc cttcttctgc aagcttggag gctgcttttt 3403621 cacatgcttc cggacggagg tctgaaacga tgacgctggc accttcccgg gcgaattctc 3403681 ttgcgatttc gaatccgatt ccgccggcag cccctgtcac caaagcgact tgttttctca 3403741 tgtcaaacac cttcccatta agaattgagt acagactggc ttacagcgaa atcagcttct 3403801 gttttttcat aaacctcttc aattgtgaca ccatcctgaa gctccgtcag tgtcatgcgg 3403861 ccgttcacaa aatcaaatac agccaaatcc gtaatcagcc tgtgtacgac tttctggcct 3403921 gtcagcggaa gggagcatgt ttttttcacc tttgattcac catgcttatt gacgtgctcc 3403981 atgatgacaa cgattcgttt cgccccgttg acgagatcca tggcgccgcc catccctttt 3404041 accattttgc ccgggatcat ccaattggcc aaatccccct gctccgaaac ctccattccg 3404101 ccgagaatag ctaaatcgat atgcccgcct cttatcatcg cgaatgactc agcgctgtca 3404161 aaataagagg cgcctgtcac ttcagtgatc gtttcctttc ccgcattgat caaatccgcg 3404221 tcttccgttc cttccagagg ataggggcca attccgagca agccgttttc cgactgaagc 3404281 atgacgtgaa cgccatcggg tatctcattt gcgacaagcg tcggcattcc aatcccgaga 3404341 ttcacattca tgccgtcctt gatttcttgt acagcccgtt tgaccattcg ttttctcgct 3404401 tccttcactt ggcctcaccc tttcccgatg cttgctgaac tgttcgtttt tcaatccgtt 3404461 tttcttggct cgcgccaagc acgacatgct gtacgtaaat tcccggcgta tggatgtgat 3404521 ctggatcgag ctctcctgct tccacgattt cttccgcctc ggcaatcgtg atcttgcctg 3404581 ccatggcggc aatgggattg aaatttctcg ccgttttcct aaaaatcaaa ttgcccatgg 3404641 tgtccgcttt ccacgctttg acgatcgcca catcgccggt aatgcctcgc tccagcacat 3404701 aagtccggcc gccgaatgtt ttatgttctt ttccctcggc tatggaggtg ccgacgcctg 3404761 tcgccgtata aaatcccggt atgcctgcac cgcctgcacg aattctctca gcgagcgttc 3404821 cttggggaac aagctctacc tcaagctctc cgcttaaaaa ctgccgctca aaaattttat 3404881 tttcaccgac ataggaagcg atcattttct tgatttgctt gttagccaga agcaaaccaa 3404941 gcccccagtc atcgactccg cagttattgc tgacaacggt taaatccttt actccctgat 3405001 ctcttataga caaaatgagc tgttcaggga tgccgcacag cccaaaccct cccgcgatca 3405061 gcgtatcccc atcatgaatc agtttcgcag cttccttgct tgatgacagc acttttccca 3405121 tattgatgcc cctttcgttt tcttctacac tagaccagtc aggctgtaaa tcgcgatcac 3405181 agcaaatacg gcagccgttt taatgagcgt gatcgcaaaa atatcgcgat aggattgccg 3405241 gtgggtcaaa cccgtcacgg ccagaagcgt gataacggcg ccattatgcg gcagtgtatc 3405301 catcccgcct gatgccattg aaatgacccg atgcatcacc tctggcggaa tattgtaagc 3405361 ctgaatcgcc tgtaagtatt gttctgacat cgcgcttaac gcaatgccca ttcctcccga 3405421 agccgagccg gtgattcccg ccagcgcagt tgtcgtaacg gcgccattta caagcggatc 3405481 ggtaaaagta tgtgaaattc cgctgctcag cttatgaaac cccggcagcg cggcgataat 3405541 gccgccgaac ccgtactcag cacccgtatt catagatgcc agcaaggcgc cgccaattcc 3405601 ttcattcagc ccttccttca attgggcaaa cacacttctc caatcaaata atatcgttgt 3405661 gatgatgcca atcactaaag caatctccac cgaccaaata gcagccgctg aagaaatatc 3405721 aagcctgccg aactccttta atcctatgga agaaaaatca aatccattcg gataccactt 3405781 tggcaggtaa atggtgaaat atttattcac tgcaccgacg agaataagcg ggacaaaggc 3405841 aagcgcgtgc cgaatcgggc ttttgtccgg ttcagccgcg gactcaatcg attcaggagc 3405901 aggagcattc tgcgaatcaa aaccgccata gccttcgcca gatgcctgcg ctttcttccg 3405961 ccttgattcc aaatagagca tcccagctgc cagcacaatc actgcgccca tcaaacccag 3406021 ccaaggggcg gcataaatgt ctgttttgaa aaacgacgtc gggatgacat tttggatttg 3406081 cggcgttccc ggaagtgcgt ccatcgtaaa cgtaaaagct cctaaagcaa tcgtacccgg 3406141 gatgaggcgt tttggtatgt ttgcttcttg gaacatgttt ttcgcaaaag gatatacagc 3406201 aaatacgaca acaaacaggc tgacaccgct gtacgtcaag acagcaccca tcagcacaat 3406261 ggcaagtatc gctctttttg ccccgacaag ccggacaatt gttttcgcga ttgatgccgc 3406321 aagcccggcc atttcaacga cctttccaaa aatagcaccg agcaaaaaca ctgggaaata 3406381 cagcttaata aaacccgcca tcttctccat aaaaattgat gaaaaaaaag gaagcacatg 3406441 gcttggatct gtcagcagca ccgcgaataa cgcgcaaatc ggcgcaaaca atatgacaga 3406501 aaatccccga tacgccgtaa acatcagcaa acctaacgcc aatagaatga tgatcagttc 3406561 cacacacaca tcccccgttt ccgcgaacta gaaagcgttt acaaaaacct gtccgcatcg 3406621 gctgtttccg tcccctttcc atatgtacga gaagcgtggg ccaactattc cgattaaaaa 3406681 aggaaagctc cttttttcgg agctttcctc taccattcat ttcattccta ttaggatatc 3406741 aacatcaacc gtaatatcgg ctgatttcat ctctttcagc aggctgactc gatctttcgg 3406801 cgccgaccag gcaagcggcg tcatcttgag aagccagtgg atcgcctgct ggtcaagcgt 3406861 tttaacatag cgcagcctga caggacggct gtgtgctgca tttgctgtaa aacgctcaac 3406921 tgctgccgta ttggaatacg tgcgccttgg tgaatcagta tataaaaatt gccttaattc 3406981 tattaaatag tcgcttcgcg gcactacttt tatgagcatg ccatcattct tcagcagtct 3407041 atgaaactct gcataattgg acggcgaaaa aatagacaga acaacatcaa attggcgatc 3407101 atgaaaagga gcacgcgcca catcggcaac cgcccacatc agatctttga atgccttaga 3407161 agcttttaag atcccgtcct tcgaaagatc tatgccggtt cctatcgctg ctttccctgc 3407221 ataatcaaac ccgcaaagcg cattcaaatg agaaccctca ccgcaaccgc tgtccaagat 3407281 ggtgaatgcc tcatgaccag atttgggatg actgatgagc tctgcaatcg catcatggag 3407341 cgggtcaaaa aaaccacatt ctccaatcag cctgctcctc gcttcaaaaa gctcggcacc 3407401 gtaactggtt ttgaccggct tcgtcagaaa gttcacgtag ccgtgccgag atagatcaaa 3407461 tgtatgtcct cgttctgtac aaatcaagct tttccctgat gccgcatcca tagaagaatc 3407521 gcagagcggg catcgaaaca tgctgaaatc aactgttcgc ttcatgataa aaaacacccc 3407581 attcattcat ttttagataa atgaaaaagg catagacaaa taaacctagg cctatctcaa 3407641 aaattggcca ggtctggcag tttgtctaca cctgtcatta tctataacga atgaattgga 3407701 taatcatgaa aaaaactccc tttctgctgt atgggtttcc ccgtttccat catacaacaa 3407761 atatccagga gctggaacct tatagtgaag aaaaatcagt actgacatgc tggtatcccg 3407821 ccaacatcat atcagcatag caatccagca tgtttttcct ttattttctc attttagaat 3407881 ataaatttta ttattgtgaa aatagttaaa aaggttgatt ttcaaaaagt gaaaggataa 3407941 aatactgcta tcatcttaga aaaagacatt cttgtatatg atcagtaata tggtctgatt 3408001 gtttctacct agtaaccgta aaaaactaga ctacaagaaa gtttgaataa atttgaacga 3408061 gttgaaaagg acaagttctt ttctgtttgc tcttattttt cacactttct gcacttccag 3408121 aatttgtgaa ggataagagc tttttttgtt tccataataa ccctcatagg agttgctatc 3408181 atgtactttt tactaaacct tgtcggtctc attgtgatta tggcagttgt attcctatgt 3408241 tctccgcaga aaaagaaaat caagtggcgc ccgatcatta cgttaattgt tctggaattg 3408301 ctgattactt ggtttatgct gggaacaaaa gtcggaagct gggccatcgg taaaatcggt 3408361 gatttcttca cttggctgat tgcttgcgcc agtgacggta tcgcgtttgc ctttccgtca 3408421 gtgatggcga atgaaacagt agactttttc tttagtgcgc ttcttccaat tatctttatc 3408481 gtcacattct ttgatatttt aacgtatttc ggcattttgc cttggctgat tgataaaatc 3408541 ggatgggtga tttcaaaggc ttcccgcttg ccgaaattag aaagcttttt ctctattcaa 3408601 atgatgttcc ttggaaatac cgaagcactt gcggtcatcc gccagcagct tacggtttta 3408661 agcaacaacc gcctgctcac attcggttta atgagcatga gcagcatcag cggctccatt 3408721 atcggatctt atctttcaat ggtgcctgcg acatacgtgt ttacagccat tcctttgaac 3408781 tgcttaaacg cgctgattat cgcaaacctg ctgaatcctg ttcacgtgcc ggaggatgaa 3408841 gatatcatct atacaccgcc taaagaagag aagaaagact ttttctctac gatttctaac 3408901 agtatgcttg tcggcatgaa catggttatc gttattttgg caatggtgat cggatatgtc 3408961 gcattaacgt cagcagttaa tggcattctt ggcgttttcg tacatggcct gaccatccag 3409021 acaatttttg cttatctgtt cagtccgttc gcattcctgc ttggactgcc agtgcacgat 3409081 gcgatgtatg ttgctcagct gatgggcatg aaattagcaa cgaacgagtt tgttgcgatg 3409141 cttgacttga aaaacaatct caaatccctt ccgcctcaca ccgttgcggt ggcgacgaca 3409201 ttcctgacgt cctttgcaaa cttcagtact gtcggcatga tttacggcac gtacaattcg 3409261 atccttgacg gagaaaagtc aacggtcatc gggagaaacg tgtggaaact gctcgtcagc 3409321 ggaattgcgg tatctttatt aagtgctgcg attgtcggcc tgtttgtgtg gtagaaacat 3409381 tgagccatat cccttttcgg atatggctct tttcattatt gataaataga ggctggcacc 3409441 tgcacatccc ggattcccgc tgcataaggc cccaagtcat actggccgaa gacgatggcg 3409501 atcccgtttg ccgtaaagta aaacattgtg tctctgttta gggttatatc ctctttcttt 3409561 acatcagaga aaaacagcac atcgtgtttt ttgatatagc tatataggta atctctcgtt 3409621 ttgctgactt ttgttttggt gttcagaatc tgatccagcg tcacccgctt ttgtgctttc 3409681 aagtcatagt tgaaggactg gacagacgtt agaccgtggg cgccccctga atagatataa 3409741 ttgagtgttt gaatgctgag cttgcctgcc gcattgtatt tgacgctgaa ggatgtttga 3409801 tattcccgtt ttaaagccct gctgttcgcc tgcttttttg tttttcaggt attcctgata 3409861 cgattgttca tgtaggcttt cagctcttga ttgattttct tttcaaacgc ggcattcccg 3409921 acgtgatgca cttgtggata cgttaactcc ttgatctttt tgtacgtatg ggtgctgaca 3409981 gtcggtgttt tcgcttgaac tgcttttaaa gatggggccg catatgcaaa tacagaaaaa 3410041 agcaagactg caatgcccgc ggctttcagc atgttattcc atttcataca atctactcct 3410101 ttgatgtcgt tgtttatcat tcccttattt aagcaataca cacttttata gactgattaa 3410161 atcgaaagaa gtttctaggt ctaacagcat gatttttcca ataaaaaaag agacacagga 3410221 tgtctctttt tttactgttt gcgcccagaa atcgcttcat gaagggcttg tgccaaatct 3410281 gtatttccga acatctctaa taccgcaatg acagtctggt ccggaatgtg ctctgcttcg 3410341 tgttttggca cgaccagatc gtccatggtt tttttcaagc tttcattcag cttttgctgc 3410401 ggatacgctt tggcgtacag ctccatcgga tcaagatcat ggttcacgca ccactgggca 3410461 aacaccaaaa tcatcatatt ttcatcgcgt tcgtaagctt cagtgagctg tttttcgttc 3410521 atttgtcatg ctccttatga aaagtatctt ccttaaagat acaggagccg atcaaattcg 3410581 tctatcccaa tggcgatgag cagcaaccgc atcgataaat gccttgctga aagcggtgta 3410641 gtcaggttca tctttagccg ttacgatgcc tagcccctct gttgtcccga cagaggattg 3410701 aagaaggtca attccttcat ttgccgcacc gatcgccttg tagtgattgt aagcttctct 3410761 gataaacgcc atcgcttgtt tgttgtcttt taactccagt cctcctgcgg catagacggc 3410821 atcatacaga acagaatcaa ccgtcaggaa cgtgccgctg gcctcaagct gctgtccgct 3410881 gccgcttgtc atatacccca gattttgact gatgatatcc actgtgattc cttcttgctt 3410941 taaggcttcc agtactgttt gcagctcttt ttcatgaaat ccgtttccgg cgagtacagc 3411001 gacttttctt gttgacgcgg ttttcactgt acgggcttgg cttaacgcag gcgaagtaag 3411061 aatttcttta gatgctttac gcttcgcggg cgccgccacg cctactcctt tggcgatttc 3411121 ttctgctaaa tctgcatcga cattgctgaa gacatcaacg acctgccgct gtacgtcttt 3411181 gcttttgacc ttcccgacct cgaagcagaa agcagaaatg atgtgctgtt tctccacagg 3411241 agacatgctg ttccagaaaa gcttcgcctg tgagtaataa tcgttgaagc tgtcgcttcg 3411301 ctggcggatt tttttgccct cgactttttc ctgatagtgg acgtagccgc cttcttcagc 3411361 tgtcgcaggc gacggatcat tgttttgcag tgagttttta tgataagcga caggtccctt 3411421 attgatcgtc atccggtgat agccgtcgta ttggttgtta tggaatggac agaccggccg 3411481 gttaatcgga atctcatgga agttcgggcc gccaagacgg atgagctgtg tatccgtata 3411541 agagaaaagc cgcccctgca atagcgggtc attggtaaaa tcgatgcccg gcacgacatt 3411601 tcccgggtgg aatgcgactt gttctgtttc cgcaaacaca ttatcctgat tgcggttcag 3411661 cgtcattttt ccaatgatct tcaccggcac aagctcttcc ggccacagct tagttgggtc 3411721 aagaatatca aaatcaaact tgaattcatc ttcctcatca atcatctgca cgccgagctc 3411781 gtattcaacc ttgccgccgt tttcaattgt ttcccacagg tcacggcggt ggaaatctgg 3411841 atctttcccg gcaatttttt gcgcttcatc ccatacgaga gaatgcacgc cgagcaccgg 3411901 cttccagtga aatttcacga aacgtgcctt tccttgttca ttgacaaaac ggaacgtgtg 3411961 aacgccgaag ccttccatca ttctgtagct gcgcgggatg cctctgtcag acatcgtcca 3412021 catcaccatg tgggcagact cagggttatt ggcgacaaaa tcccaaaatg tatcgtgagc 3412081 agtcgcagcc tgaggcattt cattgtgtgg ctcaggctta aacgcgtgaa ccaaatccgg 3412141 aaatttgatt gcgtcctgaa tgaaaaacac cggaatgtta tttcccacaa ggtcatagtt 3412201 tccttcttca gtataaaatt ttgtcgcaaa gcctctggca tcccgcaccg tgtctgcgga 3412261 gcctttagaa cccgcaaccg tagaaaaacg gacaaatacc ggtgtcttca ccgaagggtc 3412321 ctgaagaaat ttggcccgtg tgtattccgt cattggttcg taaacctgaa aaaagccatg 3412381 cacgccaaat ccgcgcgcat gcacaacgcg ctccggaatc ctctcatggt caaagtgcgt 3412441 cattttctcc cggaaatgaa aatcctccat cagcgtcggg ccgcgaaccc cggcttttaa 3412501 cgagtgctca tcctctgaca ctcgcaagcc ttggtttgtc gtcattttct tcccgctgtt 3412561 atcggtcctg tactgctcaa gctgctcgtc ctttgagtgt tcatttacac gtttgttttg 3412621 gtcatcactc atgtctgctc ccccttttta aaacgaaaca ttctacagca catttacccg 3412681 tggcgttctt catataaact gctaatccgc tcattaggat ttttggtcta catataaata 3412741 tgcggtcata cacatttgaa ataagccttc ttcacagaaa gaaaggatgg aagcgcttac 3412801 caaaaaagct gttgaatagg ggaggtcata tcatgcttgc catactcggt tttgtgatga 3412861 tgattgtctt tatgtacctt attatgtcta accggctttc cgctcttatt gctttgattg 3412921 tcgttcctat tgtgtttgcc ctgatcagcg gatttggcaa agatctcggc gagatgatga 3412981 ttcagggcgt tacagacctc gcccctaccg gtatcatgct gttattcgcc atcctgtatt 3413041 tcggcattat gattgactca ggcctgtttg atcctctcat tgccaaaatc ttatcgtttg 3413101 tcaaaggaga tccgttaaaa atcgccgtag gcacagcggt tctgaccatg accatttcgc 3413161 tggacggaga tgggacaaca acctatatga ttaccattgc agcgatgctg cctctctaca 3413221 aacggctcgg catgaaccgt ttggtgttag cgggaatagc gatgcttggt tcgggggtta 3413281 tgaatattat cccgtggggc gggccgactg cgagggtttt ggcttcctta aaattggaca 3413341 cgtcagaggt ctttacaccg ctgattcccg ctatgatcgc cggcattctc tgggtgatcg 3413401 ccgttgctta tatcctcgga aagaaagagc ggaagcggct cggcgtcatt tcgattgatc 3413461 acgcaccgtc ttccgacccg gaggccgcac cgctcaagcg tcccgctctt caatggttta 3413521 acctgctgct gactgtcgct ctgatggccg cactgatcac cagcctgctg ccgctccctg 3413581 ttctttttat gactgcgttc gccgttgcct tgatggttaa ctatccaaat gtcaaagagc 3413641 agcagaaacg aatctcggcg catgcgggta atgcgttaaa cgttgtctca atggtgtttg 3413701 ctgcgggcat attcacaggc attctctccg gcacaaaaat ggtggatgcc atggcgcatt 3413761 ctctcgtttc actcatccct gatgccatgg gcccgcacct gccgttgatc actgcgatcg 3413821 tcagcatgcc cttcaccttt ttcatgtcga atgacgcctt ttacttcggt gtccttccca 3413881 tcatcgccga agccgcttcc gcttacggaa tagacgccgc tgaaatcggg agggcctcct 3413941 tgctggggca gcctgtgcat ctgctcagcc cgcttgtgcc ttccacctat ctattggtag 3414001 gaatggcagg cgtcagcttt ggcgaccatc aaaaattcac tattaaatgg gccgtgggaa 3414061 caacgattgt gatgaccatt gcggcgcttt tgattgggat tatttctttc taaatgtatg 3414121 agcttgatcg tagcattgag tgagtacgtg atttacagag gggagaagat caaataggat 3414181 attatgagtg aatagaagat tcatgccaac aacttctcat tacaatcata agagcctgct 3414241 atattgcagc aggctctttc acatttggca ttattttttt gtatagcgca cccagtcata 3414301 atgagcgtat agcggattta caccattgta ggagccaagc cattcatcga cacccgtgcc 3414361 attccacaag ttcatcatga tctttccagg tgttgtcgga atttggtttg ttgcagtatg 3414421 ttttaattgc ccgtcgacat accatttaat agagtttggc tgccaatcga atgcatacgt 3414481 atgataggca ttggctgcat caaacccgag atcaacaatc ttctcatggt ttcctgcacc 3414541 atttgtataa tagttaaatt gaaccttcgt tgtgtctttt cctaaaaatt cgatatcaat 3414601 ctcatcccaa ggagttccat ctgttggacc tgtgtaagtg aagaacgatg aaacgatccc 3414661 tgtgttttta gctggtttca ttctgacttc ataaagtcca tagccatatg tttgaacaga 3414721 acggttttcc ccgcagtcaa acttgttata agctgggctt gttagcgcta aacgcatttc 3414781 acccaatgac gtcattgata cgttattagc ccgccacgtg cagttgaaca tatttccatt 3414841 cgaataacca tctgcttttt gccaaaaacc ggagttatag ccgttaaaag ggtcaaaaaa 3414901 cgatccacct gtttgagctg aggcagtagc agtgactgca aacaaactca taaacaatcc 3414961 agtgacaaga agcagcaaca ctcgtttcag ataaggcata ttggcattcc cctttcattg 3415021 aaagcgtttt ctatgttgat cttacatgat tcttttaaaa gggaacatcg gtcaaaataa 3415081 tgataatatc gaatcttact aacttgaatc ctgtaactat catcatcttc cctctgaaaa 3415141 aaataaaaac ctaaattacc atcagcacag acagagatga tccgcactca ttgcaattta 3415201 ggttttgcct gctttatcag taacaatcct accattttca tatgtgaatg taagaaaaag 3415261 tgaacacaag gaaacacaaa tgtcagcgct ctcattatgc ttgtttaact accctttcta 3415321 tgtgaatggt taaatacagc agctcgtcac ttgtgagctt gtgctcatac tcccgctcaa 3415381 tgtaggtttg gattttcttc gtgcattcat acgcgcgatg atacttttct ttcactgtat 3415441 ccagcaaaaa atcgtcctgg ctttccatgt gagtgccgtt aaatagacgc tgcgcgaaaa 3415501 actttaagtg ggtgacgaac cgataatagt gaagcgattc ttcgttgaat tcaatcttaa 3415561 aatggtattt tacaatactc aaaatctctt gcatgacttt tgtaatgttg ataatattgg 3415621 gcatctcttc attcagctcg gcatttacaa tatgcagagc aataaagcct gcttcatcct 3415681 ctggcagaga cacaccagtc ttgtttttta ccataaccaa cgcttctttg ccgatcgcaa 3415741 attcgtcttt gtagagccgt tttgtttccc acagcaaggc gtttttgata tcaagccctt 3415801 tctggttgcg ctggatggca aagttaatat ggtcggtcag cgacacatag atgctgtcgt 3415861 tgagcttttt gccgagctgt aattttgcgt agctgataat ctcttcggat acttccatac 3415921 actcgatcgg tatatcatac aaaagggttt tgaacttttc tgatacatcc ttgttatcga 3415981 gcgtgaacac tttctcaatg cgggcttcat cgacatcatc gccggacttt ttctgaaacg 3416041 cgagccccct gcccatgacg accaattctt tcccctgttc attgaccacg ctgatcacat 3416101 tattgttgat caccttcgca attttcatgg catgtccctc caaatctact aagaacagac 3416161 tatatcttga ttgtacattc tttttgtact aggtcaatat catcagggaa agacggaagc 3416221 tggtcagtac aattcactcc gtacctgctg cccgggctgt ttttgaagca gcgcctccag 3416281 atggcgttca aatgatgcct tgtcagcttt ctgctttttg acaatgctgt tcatgatttt 3416341 aatgctttca gcactgtatt gtgtatattg ttttttcagc tgatccagct gctgtcttgt 3416401 cttcttcgcg tttttcggtg tgacttggtt gatgagtttg atcatactgt ctgcggtctc 3416461 aaaaaaaccg gctctatttt ctgtcagctg ctgaatttcg atgcggctca tatcttgatt 3416521 acgcgttttt tgaagcaagg caaccgcctc gctgttttgt tttttgagcg atttgttctc 3416581 aagcttaatc gattcgagat tctccttcgc aatgtctgct tcttcttcag tcatgctgat 3416641 tcgcacgaag tattctggat tgccgattcc ataatcaaat gcttcgctca cttgtatcat 3416701 ggaactgaac acaatggcca gctgcctgtc gcttgcgagg gcttggaaat cctgcttttt 3416761 cttactgctc atcggtttgg ctgcggtttg ttttactgtc ttttgatcac agtctgcgaa 3416821 catctgagcc tcaccttcac tttcgcatgc gctcatcaca agaactgtga ccagcaggct 3416881 tatacacaag cctattcgcc tcatgctctg tctcctctct gctgaatccc ttctggaaaa 3416941 taccataaaa tatagttaaa tggtaccaga tgcacctaac cccagcaata aatcaaaagt 3417001 atgatttgaa gcgaaaaaac ataaatattt tgtaaaaatt gacgtgcatt ccattctttt 3417061 caggcccatt tctcgtacaa tagaagtatc gttaccggag aggggctctg atgatgaaac 3417121 gttttacgaa acaagaaaac agctgggtgt tatatgactg ggcaaattca gcttactcaa 3417181 ttgtcgtgac caccgcggta tttccgttat tttataaatc agcagctgcg gaaagcggtg 3417241 tcagcgccgc tcaatcgact gcctatctgg gctataccat tgcgatttca acgtttattc 3417301 ttgcgatgct cggccctatt ttaggcacaa tcgccgacta tgaagggtgc aagaaaaagt 3417361 tcttcggttt ctttgtgtca gccggtgtcg ccagcaccgc gatgctcgcc tttatcccta 3417421 gtgaacattg gctgctattg ttgctgtttt atacggtatc ggctatcggt ttttccggcg 3417481 ccaatgtgtt ttatgatgcc tttctcgtgg acgtcacgcc tgagaagcgg atgaatctcg 3417541 tctcggcacg gggttttggc ttaggataca ttggaagcac gattccattt atcatcagta 3417601 ttgctgtcat cctgctcgca caagcagaga ctattccagt gtctgtatcg gccgcaagcc 3417661 agctgtcctt cttcataacg gctgcctggt gggggctgtt caccatccca atgattaaac 3417721 atgtccatca acgctattac atcaaaaaag aacctcatat tgtcatcaac agctttaagc 3417781 ggctcggcca aacgatgaaa cggatcaggc aataccgggc acttttcctc ttcttgctcg 3417841 cttatttctt ttatatcgac ggagtcggca cgattattac gatgtcgaca tcctatggat 3417901 cagatttagg gatcggctcc tcaagccttc tgatcatcct atttgtcacc caggtagtcg 3417961 ccgcgccgtt ttcgattata tacggaaaac tggcagaacg cttcacgggg aagaccatgc 3418021 tgtacgtcgg gatcgtcatt tatatgatcg tctgcgtgta tgcctatttt atggagacaa 3418081 cgcttgattt ctggatactg gctatgcttg tcgccacctc gcaaggcggt attcaagccc 3418141 taagccgttc ctatttcgcc aagcttgtgc caaagcgcca cgccaatgaa ttctttggct 3418201 tctacaacat ttttggaaaa ttcgcctcaa ttatggggcc gctgctcatt gccgttaccg 3418261 cccagctgac cggtaaatcc tcgactgcgg tgttcagcct gatcattttg tttgtgattg 3418321 gtattgtgat tcttgccttt gttcccgagg aaaccagcac agatgtcagc cagcagcaaa 3418381 atgacctgcc cctttaactg ggagcaggtc attcatcatt tattcgcttt attcaccttc 3418441 agctgtttcc ctttgacggt tgtgttcttc atcactttga gaacatgagg gcctttacca 3418501 tttaaaatct caacgtatga ggcgttatcc atgatcgtga tgatgccgat gtcgtcagct 3418561 gacacaccgt caattttggc aatcgttcct acaaaatcaa cggctctgat tttctttttc 3418621 tttccgccgt taaaatacag cttcataatg tctttattca gctcttcgct tttgtccttt 3418681 ttgctttccg gacggtcatt cagtttagct agaaattctg gtttcttcct tgccacttcc 3418741 tcttgagaag gtgcttctat tttttggatt tcaaatccga tatattcttc aatgtcggct 3418801 aaaaaccgtt tttcgaaggc cgtgacaaac gaaatggcct ttcctttgtt ccctgcgcgt 3418861 cccgttcggc ccgtgcggtg gacatagctt tctttttcaa gcggcagatc atagttgatg 3418921 acaagggaga tattttcaat atcaatcccg cgcgcggcga catccgtcgc cactaagtaa 3418981 cggtactcgc cacgtttaaa ttcattcatg acgtcgaatc ggtcttcctg aatcattccg 3419041 ccgtgaattt tatcgcatgg atatcccaag tcatccaatt catcggtcag ctgattgacg 3419101 tgctccttcg ttcggcagaa aatgatgcag ctgtcgggat tctccgtcat cagcacatct 3419161 ttcagcaatg aaaacttatt ctcttctctt acttgaatca ccgcatgttc aatatttctt 3419221 gtggttaggc cggccgcttt gacctcgata tgctcggggt tttgcatata ttgacggctc 3419281 agcttctcga tatcctgcgg aagcgtcgct gaaaacagca tcgtcgtacg ctcagtcggc 3419341 agatgcttga taatcgcctc cacctgctca atgaagccca tattcagcat ctcatccgct 3419401 tcatcaatga ccaaataaga gagacgatcc aacggcagcg tgcctttttc gatatgatcc 3419461 agaacacgtc ccggcgtgcc gacaacaatg tggctttttt gcttaagctc agctttttgt 3419521 ttatcaaagg aggattttcc aaatacggct gtcgctttga tccgtttaaa tcgtccgatg 3419581 ttcgtgatat cttcctttac ttgcaccgca agctcacggg tcggtgttaa aataagcgcc 3419641 tgcggcttgt tttcatccca attcgccagc tcacagagag gaatcccgaa cgaagccgtt 3419701 ttcccgcttc ctgtctgtga tttgacgaca agatcctttc gttcaagggc agcggggatc 3419761 acactctgct gcaccttggt cggttctgta tatcccagtc cttccaatgc tcgtaaaatg 3419821 tcatgactga tttgatagtt tttaaaatga ctcatgtata aactcctgtc tcttgcagat 3419881 gttctcatta tactctaatt gaccaaggca tatgtgtttt gtcgaaaaat gatgtattaa 3419941 aagccagcga ttccctggcg ttttagctcc tgaacagcca atcgcgccag tgcgtcggcc 3420001 cccgcgcgat tcgggtgcag cgtatctcca tccatataaa gcccgagtgt tctttccgga 3420061 ccgatcgatg taaagtatgc cgagctgagg acatttaagt caatgagata tgttttttcc 3420121 tcttcggcca aagctaaaat agaggccctg taccatctgt ttacagacga atggatgcct 3420181 tcagaagtaa aatcggttgc ccggccctga ggcgttgata ggatgacgtc cgctcctttc 3420241 gcttttacct gacgaatcat atcacgcatc acctctttaa actccgcttc agattcttta 3420301 tgcttcggat ttgtgtcatt aatgccaagc tgcaacataa aataatctcc gggtttaata 3420361 tacttcagaa tcgcctcaag ctgtccatca tttctgaacc ctctcgcgat ctgcccgcca 3420421 gacgccatgt ttctcacttg aaaggtgtgt ttatcgatat agtgaggcag catctgcccc 3420481 cagcccgcct gcttgctgct gttgagcgga taataattgc acaccgtcga gtcgccgccg 3420541 acataaatgg ttcgattcgt taccggctga tcagacaatt tctttatttt caaggcgctg 3420601 agcgtaaaag cggtgcctgc ctttccctct gtcaccagca gattcagctg cccgtcggtg 3420661 acgggaattt ggaacgtatc ctccgcgcca tcccctgtca tattgatgac ctgaaacacg 3420721 ccctccgctg ccacactggc ccttgccgta ttgccaagcg tcaccttcac ctcataaagg 3420781 ccattcggga gatcaacatt aaacgtgtta ttgcttttcg tcccatacgc taaaaactga 3420841 accgcatcac tcttcacacc agccccggat gccgccacat ccctcatatt ctccggtgtt 3420901 tgaaaaccgt agccctttga ccggtcatac cgatcagacg ccctgacacc aatataacca 3420961 ggctccatcg aaccgcttcc aaagtcaaac tgatacacct tcggctccgc cgccttcaca 3421021 ttctcaatcc cgccaaaaca cagcatcagc atcatcacaa aaaccgctgc catccatttt 3421081 ttcatcaaga ctccccctct atgaaaacga atacattaat gcatactcgg tgattgtttc 3421141 tttatgatga ctgaattaag aaaaaaattg cgttgaggaa taaaaatgag gggagagtct 3421201 caagaagggg aaaatcagtg tgacttcttg tcacacttga tcacatccca acctccgcaa 3421261 tagaagctta tttggttttc ttcgtcatac acataataac ggagtctttc ccattgatcg 3421321 tcagtcggta caatctccaa tgcaaccgaa tcgatggatt caaggtcatc cagctttgat 3421381 gcactaatgt tttcaaaccg caattgaatg tcacaggttt gagcagatcg ttttcattca 3421441 aacacaggaa tatgaatata acgatcatct tctttcatat agaaagaaaa ctcgtttaat 3421501 gtaaatggac ctgtatcctc atcagaaaga tgctgtttca atttctcgta ttgtgtgata 3421561 ttcaaatgaa ttccctctat ttatatgatt caccgccaat catataaatg tccacagcat 3421621 cgtattcaaa ccatatgatc cgttcgcctg agtccgttag gcattggagc ttcccttctg 3421681 aaaaatagct tttatccggt tgaggatcag tgatcagaaa aacatcatca ttgatggaag 3421741 ctagcagaaa gagaaaatct gcaatatccc ggtctgcttc ctgtaatatg gattggaaat 3421801 ggaattccct tttggccagc ttcgtcacct tgtaagcatg accttcaaaa tactcggaca 3421861 ggtcttctat aaatgaacca gtcgttatta cctgtatcat gattcgatcg taggcaagcc 3421921 ctgcccaaaa acgataaaac gactctgcat cttcaagttc gcatgccata acggtttggt 3421981 caggcttaag ctcgatcatg tccaaattgc caatactgct tatagaggtt atttccataa 3422041 aatcttcccc ttatcagttg gatagcgcaa cgcaaatctc ttgtctgact tgttcataca 3422101 agagaatgtg atgatacaga tccttatcgt ttttgatcat atccggaagt atgtcaggat 3422161 acagctcaaa aaagcttttc tccaacgaac gccgctgatg ccggggtatc cttttattcg 3422221 ccagcacata atccaaactg ccagcaacaa gcataaaaaa ctcatagatt tccgcttcaa 3422281 agccgtacaa ttcatcaggg tactgctttt cttcaagctc tcgctgtctt tttctcagtt 3422341 tttgaagcac gttgatcctc tcccttccgc aataatctca tttatttcga aacagaatag 3422401 gcggatcatt atctatcgcc tccaacagct cttcaccaaa cacagtgatt gcacatttcc 3422461 acgggtctcc caaaagtccc caggagaagt cctgatgaaa aaagaaataa tagtctccat 3422521 ttggaaatac gggaacaggc cattcgccaa attcatcctt aggcattgcc tgatgaggac 3422581 taaaggtata tccgtcatgc tgccaatcta gtgcgtacat tacatcgttc tttccagtac 3422641 ctaattgaaa tgcttttaaa atagaagtct ctaaatcact tagcactccg ctcacatcat 3422701 tatgaccagc tttactgctc atcgcgcttg agatatcaaa cactcgatat ggatcaggcg 3422761 ggatgatgtg atgacatctg cttccgggct tccattttat gatcttgttc acttctgacc 3422821 agatgcggtc ttgttttgtc tgacttaaag cgcgccaatt catcataatc tcatccctac 3422881 accttattgg atatcctgct tataaacacc agaagaggcc actgcgtaaa cagcgtaact 3422941 tgtcagtttc agctgttgaa catctaggcc ttcaccgttc gaatcacagc atgttatctc 3423001 ttccatctct tgactcacat cggcagaaat caaataaaga gacgacttaa ggtctgcact 3423061 gtaacaattg aacgtcccaa ccaaaaaacc ttcttcggat atcgcgagct gatcaaatgc 3423121 ttctgagtcc ggctctttat ccgacagaat ccacacccgt ctcacgaccg tttcatcaaa 3423181 tgcggcaatg actgcatctc cgtaatacag catataaatc aagccgtttt tttctgcaag 3423241 tccataacaa tcatctacag caggcgcatc catttcttca agctttctat caatgtgtat 3423301 ttccttctgc tgaccatcta acgtaaaaca ccacacacta tggccgttgg gattctcatc 3423361 atgataaatc ccttcatcac ataaaccgac ccaaagctgt tgtttctaat ccaaaagaca 3423421 gcaggaaacc cctgaaggca agtgaaaaac acttttcacc cttccctctt ctgaaaaaac 3423481 ctttaccttc ggctcgtacg attcgtaata aacgaagaca tagccatctg cacattgttg 3423541 aaagagcaga atatcactgt atgaaatctg ctctttcact ctaaaatccc gaacatcacc 3423601 ggaaggatca tagattgtaa tggtgatacc acctttcaac ccttttccaa tgtagacacg 3423661 cccctgtgga tcagcatgga aaaaacaatc ttgggtgttc tcgttgatga ttttattcaa 3423721 ttttaatttt ttcattggtt atgctcctag gttcgaaatg aaatgataag aataaaccat 3423781 ttattagcta ttagtaacgg acaacctagt ttcattaatc gttttgggat aaatctactt 3423841 tccaattcag ccttaaatca tttagtgttt aattggtatg cataaaacga ttgatcatca 3423901 aagcgaactg tttcagcttc tatagcaatc agcattctgt tcatgtcaat aagaaagtta 3423961 gcatttgatt gatactccgg aattatagaa tttgatagat tcccgattcc ttctggatga 3424021 taactcatct caaatacttg ccaattgtat tcttccggat ctattttttc caatctcatg 3424081 tcgccaacat ctgcactata ataagcggat gccacatttt gaaatgaaat tttatgcgta 3424141 tattcacctt catcttcaaa aaccttaata tcaagtgaga gttctttttt aaacacatta 3424201 aaatctaaat gaaggacact gcacccctta tctatataat caacccattc attaatcgtt 3424261 tgatacattg tcatcccctg cctcttttta aacaataacg ccttgccacc aagcagaaaa 3424321 caaattactc cgtatattgt ttgatccaat catttaaatc atctgttgaa tgcaaataag 3424381 tttctgatga atctttcaaa tcaatcccac ttagaaggat taacatatcc cagactctat 3424441 cgtcttctac ttcggggtca tccgcataaa cataagttcc agcccaatcc gacacttctt 3424501 ctcttgttgt ttgtccattt aagacacttt tgattttatt tatgcattct attagatttg 3424561 tctcgctcaa tttgatcacc acgtattcaa gtactaaatg attttttatt agtatgcaaa 3424621 gcaccgtact gatatttaga tattgaagct ttttccgtaa aagatatgtt ccaaaaggtt 3424681 tccaatctac caataaacaa gctcacatcc gtattccgtg tgcaatatac ataaaccaaa 3424741 ctggcactta ggctcaacca aaataaaact atgattgaga atcccttcat cgaactcaat 3424801 acactccaat aagcagtcaa ggtgctcgag acattttcca aaagaacaaa ctaacgcacc 3424861 aatttcgctg ctgtattgat gaaacagcag aacgtcccgg tcatcgtaag caacatatga 3424921 ctgagatatt ttccagatca gctgtttcgc ttccgttttt tcgagggcat caacctcacg 3424981 ggtgttggct ggtattgaat ttgataaaac cagctcaagc aattgcctgc tttgcgccag 3425041 atcagcaaaa cgataagtga agcctctttc tgcacaaggg actagttttt ctttgatttc 3425101 gctcatcaat aaacgtcttt tattctcggc gagtttttcg atcaatcttt tttgcatgag 3425161 ccgcattccc tccgctgtca atttctcaac ttcttttaaa ttgattcatc attctcttgt 3425221 tttcgttgtc gttcatgttt agatttgttc taaaaaagct tgtatcgctt atcgatacaa 3425281 gctttatctt caactgctta aaactcaccc agtgggcttt tcacaaaacg ctgggaacct 3425341 ttttggcaaa tcctcttcat cccaatcaat tctatatttt tagattcttt tgtcatacaa 3425401 ataagagagg atggtaacat ctcttattta atgttccatc aataaatgcc ccatttttat 3425461 ccaatgcaga aattatttat aattaaggaa gtttagaagg attttttgta ttttcaagat 3425521 ttaattttaa agcggtcaca aaagactcta gcttttcttc attacaatta atttcgaaca 3425581 agttggagtt cgacttactt tctttataat catcaaatat aattttaatc ttaattctgt 3425641 aatttccgtt ttcttgatca atactaagaa ataagaatgg ttcaatagtc tctaaactga 3425701 tactgtcttg atttcctttt atcatagttt cgatcccaga tatcaacacc ttatattcac 3425761 tttctaataa aacagcagaa aaatcgcgaa cgacggcttt cttattttcc aacaattcaa 3425821 atacagataa aataaatgga tcatcgtcca actcttgata ccttctcggt gttaattcaa 3425881 gttctataca atcatctttt attttggcca tatttcctcc tcatttaaag tttaagtgag 3425941 ggtagttgtc atccccccct cgcttaacct tattaacgcc ttctcttaga tttatttcct 3426001 tttccgtgtg tatggaatac gtgtttagaa cccttagctc ttgaacttcc ataagctgtg 3426061 attactttac cccttttatt taaaacaact gtagcttttt ttccaacata tttcgttgcc 3426121 ccattaggtt gttttattac ttttttaggg cttcgcacag cattcagttt ggcccttaaa 3426181 ttgactccac ggcctccatt tcttcctata gattgattaa gtccatgtct tgtatgacct 3426241 gtgattttaa ctgccttctt cgtaaactta taggcgcgac tagcaccctt aaatatcttc 3426301 ccaggaccaa aattagaagc agctgcccaa gcagcacctt tccatccttt acctgattta 3426361 tatgccttat atccatcata ggctgcaaat ccggcattta ccacaagcca tacccaatgc 3426421 ccgtccggat caacattcat cactgggtta ttatttccat aagcataccc attctgatcc 3426481 aatgaatctc cgtcgctgcc cgggtctggg tcgagcgata ggaacacgcc gtttcttggc 3426541 tcgtagtagc gggccatgag atagtacagg ccggtttctt cgtcgtattg gtagcctgcg 3426601 tagcggtagc gattgtcttt tacttcgtcg cttgcttcgg tttttgttgg atttccccat 3426661 gcgtcgtatt gatacttggc aacggttttt ccagtgctgt ctgagatcgc gatgatgtcg 3426721 ccgtgagcgt tgtagtgata gaaatatttc ttaccatttt ctgtgtagga taacagctgg 3426781 ccgctgtctc cgtacgtgta tgattttgtg acgttgttgt ccgcgtctgt ttcatacaag 3426841 acgttcaagc tgtctccgtc gtagaagtag ttcgtgactt ttccgttgac ggttttttgg 3426901 attctgtttc ctttttcgtc atacttatat gttgcgaatg gcttgtcttc gccttttttg 3426961 gtaacggcgg tcaggttatc ttctgcatcc cacgtatatg tgaatttgcc gtcggatgtg 3427021 cggttgccgt ttttatcgta agagatgctt tcatcattga cttttgtcag ctggttcatg 3427081 atgttgaagg aagcgttcac cgttttgctt gagccgtctt ttatagttgt aacggttttc 3427141 cggtttccga atccatcata tgtgtattca ataacagtac cgtcttcatg ggtttctttg 3427201 acaagctgat tcagcttccc atactcatat tgcaccttgc cgcttgctga gctgtttatc 3427261 gttgtgcggt tgccgttggc atcatattca tagctttccg tcagaatgtc tccgccgttt 3427321 ttgtcaccga tatgcagcga gcttacaagg tttctttcgt catatgaaaa acttgttccg 3427381 ccgccgttgc ccgtaataaa ggtttggacg tttccatttt catcataatc aaatgaatat 3427441 gaggatgtac tgtctttcat ctcaatcatt tgatccagct tgttatacgt aaattgattc 3427501 gttccttttt ggtccccatg aatccacgag aaggttttca gcttatcgga gtcactagga 3427561 tatgtccaag tttggctgcc gccgcggtct gtcagttcgg ttaaacggtt tttgttgtca 3427621 aatgtccgtt tctttgtggt gttctgctct ttattgacga ccgacgtttc atttccattt 3427681 ttgtcatacg tgaaaatgta cttttctgta ccgttatacg actttgattt cacccggtct 3427741 gttccatcat aagaaagaga cacttcgttg ccatttggtg aaatggtttt ggtcaggttg 3427801 ctgttggcat catattcgct tgctaacaca ttgccgagag ggtcagttgt tttgacaagc 3427861 ttgcccatga catcatattc gaatttatag gtttgatctg ctcctgcccg gatggttttg 3427921 cttacctcat tgccttcctt atcatagctg tgaaggatag acgtgccgtt agagagcgtc 3427981 atgtttgtca attggtctgc ctgatcatac gtataggttg ttttttcacc ttttgcatct 3428041 gtttcagacg ttttcttacc agtttcatcg taatcagttg aagtggcgta acctagttcg 3428101 tcctcttcct tggtcacata gttgccatta ctgtcatacg tgcttttagt cagaaggctt 3428161 ccttcaatca aacggatatc atcaaaccag actgtgcctg tcgcactctt ttggaacaga 3428221 atactgatat cgactttatt gatcggcttt gttttaggga tgacgacagc tgctcggttc 3428281 cattcctgtg ttccagaagg gaatttcgca ttgtagatgc ctgtgctgcc gtcagcgtaa 3428341 gtgacattcg cctgcagaga atagtctttt tcatctgtaa atttgacgct gcttgctttc 3428401 gacattcctg tcagtgtgag ataaaccggt ttgtcatttg cgctttgccc taagacaacg 3428461 gtttgttttg ttactgatcc ggcttgggac gcactggtcc gggcagcttt taatgataca 3428521 tcatcattaa agccttcttc agaatcaacg gatgctccgc ttacattcca gttttccgtt 3428581 gctgatgtga agctgctgtt ttgaactggg ttatagcttg atgatacttc gcctttttcc 3428641 agctggactt catcaaacca tgcttttcct ttgccatctt tatctttatg atcgacttcc 3428701 atatacacaa cagctttgcc tgcattcgct ggagtcgtaa aagtgatttg ccgttttgtc 3428761 cagtcatttt ttccggctaa tgcactgtat tcattgtgaa tccattgaat tcgtttttga 3428821 tctttgtctc gcaaatcaat gttaaaatag gctcttgatt tcgcaagatc tgttttgatt 3428881 ttcccgctta atgtataggt tgtattcggc tccagctcaa ctgtttgtgt tgctgacgaa 3428941 tacccatgat ctgttccggc agacgttgat tggctcaaga cctccaatgc ctttgatccg 3429001 gaaagaactc cgcttttatc ggcgatgact gaaattttgc cgctgtcttt agaggcagtc 3429061 agattccagc cggatttttg agcttcaaag cttccatctt tcaaaatatt agttgaagct 3429121 gataaatctt tgctcgattg aatctggttt ccatatttat cataaacagc tgctgacgat 3429181 gattttccgc tctgatcggt ttcggataca gcatccagtc cgtcataagc aatatccgtg 3429241 acattgccct cggtatcctt catctttgtg acatcgttgt ttttgttgta ttcgtatgtc 3429301 tcagttccat atgcatcttt aaccgacgta acgttgccat ctttgtcata ttgatagctt 3429361 tccgttgctt ttccggtgcc gacgtcattt ggatctacat cttctacaac attgttgcct 3429421 tcatactttg tattcgttgt aatttttaac ccttccgcat catcaatgac ctgaatcgga 3429481 tttcccgctt cattatagcc atactgtact ttccggccat ttggctgtgt catgagaagc 3429541 gtctttttat cagcatcata gctgtagaca tatgtttctt ttttagcgtt gatcgctttt 3429601 tcgagacggt gaccgctata ctgatattcg gtaaagacag gctttgcttc ggtactgtta 3429661 gctgaatatt gtttgacaag gcgcccttca ctatcgtagt catagcttgt gacagtcccg 3429721 tctgtatctg taaccttctt cagcaaatca ttctcatatg agtaggtgac tttcttattc 3429781 ttaggtcctg tgatggacgt cacatggccg ttttcatcat aggtaaatgt aagcttgcgg 3429841 cctgatgcat ctgtaatggc ggtcagttga tttttgtcat tgtaagtata gacagttgca 3429901 ttgttatggc catccactac cttttggagt ttgccgcctt ttttattgaa ataagcgttg 3429961 gtttgatcct ttgtttttaa tatgaactga tcagctgttt ctgttaattc aagatataca 3430021 ccggtcggcg gctgatacgt gccatcggct tttttcgtga atcgatgtgt cgtagcgtct 3430081 tcatcgatat acattgcccc gccatccgtt gagatgacag atgtttctgc atcagcatac 3430141 cagccttgtc caaataagtg atcagagctg tcaagactgt tgtaggttct cgataagcca 3430201 agtcccggac cgcgtccatc aattgacaaa tcttcttcat tcacaatgac attgcctgtc 3430261 gcaccattta actggccgct tgggatatca atgatagacc agtactcttc tgtacctagg 3430321 aattctgcgc cttcatggaa cgttgggtta aagggcgccg ttggaatcgt ttcaccattc 3430381 gcatcatagg cgacaagcgt gaaagaataa ttcttcttcc ctttgtaatt cccatttgca 3430441 ttgttataga caggtgatgg atcgagggct aattccccgc cttttccatc tgtatgaagc 3430501 ttatagcttc cggctttgat ttcctcagaa gtcggccaga tgtttttatt ttgggttgtc 3430561 caatgatcag catcaccaac atcaaaggac tgatattctt taccgttgta aatgttaact 3430621 ttatagccct tcgcattttg aaccttttcc catatcaaat tcacataacc cgtttgactc 3430681 gattttgtat ttgtatacaa atagccagtt acattctttg gcctagcgat atcaggaagt 3430741 gccggggtag cagccgggga tgcaatggct tcgccgtctt tgttgtatgc gataatttta 3430801 aacgagtaat ttcttttggc tccatctccc ccggcgtttt tataggttgg tccgggattg 3430861 atcggcagct ctgctccgct tccgtccttt aggtgaagag catattttcc cgccttgatt 3430921 tctgcacttg tcggccagat ctttttccct tttgtggtcc aagacgtctg atttccgaga 3430981 tcaagtgtct caaagccttt cccattgaac acctgaacct tatagccggt tgcaccggat 3431041 acagctttcc aagaaaggtc gaagtatcct gtggcattcc cattattgta gccctttgct 3431101 gacggtgctt gtgcttttcc tacattaggg ataacgggct ttgccggtgc ggacatcgct 3431161 ccttcacctt ggtcaaatat cgcactgacg ccaatccaat agtttttgct tgtagcatag 3431221 cttccgccgg aattcttata gaccggggat ggatctaatg ccaattcagc tccatccttg 3431281 ccgtccagat gcagtttata tctcttggag gcaatttctg cgctcgtagg ccagattttt 3431341 ttaccttttg tgctccacga cgtgacgttg cctgcagaaa tcgcttgata ttccttacca 3431401 ttgtaaatcc ataccttata tccttttgcg ccttcaacct ttttccagct gatatcgaaa 3431461 taaccagtgg aatcgccgtt gtgataggct ttgattgtag gtgtgtttcc ctttggaatg 3431521 gtatacgtca cttcaatata tggtttattg gcggagttcg ctgaagaaat tagttttttc 3431581 caatattcct tgccgtttcc gtttgtatga agcttaaatc catagttggc cccgccggag 3431641 ttccatgact ttacagcagc ggtcacatca taactcgccc actgtccttt atggacgtcg 3431701 gcttttccga tatttttaga tgccggtttg gtgttccatg tcacttttgc attatcataa 3431761 ttgctgttga ccgtatccag ccaaaggccg gttgcctttg ttccataata ggaatgggct 3431821 acgtatgttt ttaatgtagc tttagtgaca gtcatatttt gaattggctt taggttgtta 3431881 aatttcatga acgcatagtt tgtgcctgtt gttttgtcat aatagcccgt tttcagtaca 3431941 taggccttta aattagcatc ccatttttgt gaggaggccg aatagttcgt cgtcgggtag 3432001 gcactcatga caaacgtatc cgatgaaaca gataaagaag ttgacgggtc gatagatact 3432061 ggatatacgc gttctgggtc tttcagccag ttctcgtctg ccgtaagatg aagcaaatac 3432121 ccttcttcat tcttttccag cttatagctg actttgtctg accgttcaac ctcgccggaa 3432181 agctcatcta gttttgaatc cgtcataaaa ggcttaggca cagaaaaaac aacttttcct 3432241 ttttcatcag aaaaatcaat ggatccatcc tcttgttctt tagcctgcaa atcggttttt 3432301 aactgaaatg taaatgtgtt gtatccatta tactgatgaa ggactaaatc ttcttttatg 3432361 ttttcattga atgtgaaagt ctgaagatca atattcggaa acacatccgg atacacaatc 3432421 tcattactgt cagtcttata atctgctgag gtatctttcg gagtaagtga agttttattc 3432481 gggcctttcg cttctgctag tgaatatgta accttatggt cattatgctc aaaagtcgca 3432541 taaagcccgt tcttcatttg cttttgaaaa tctgaattca aaatagcgtt ctctgtctcg 3432601 acttgtttgc ttgtcgactc ttttaactca ggagaaatgt cttcccagtc ggcatccggt 3432661 gtttcctttg tatgaatagg atcaaggtat acttcctgtt tatagacacc gtcaccttca 3432721 taatagagtt ttgtattttc tgttctttca gaggtgatct caccctcttt gtttatatct 3432781 tttggatcaa aaggtacagc ttcctcagtt tgttctttct gaagagtttc ttctggatca 3432841 tcggcagcaa tacggtttcc attctcttct tctgtagatt ttgctagtac atcggctggc 3432901 actaatgaaa tcattaaagc caacactaaa aatgctgcaa tgaacctttt aaagtttcgc 3432961 ctctttcttt ttttcatttc ctctctcctt ttgtaataaa agtaatattt actcaataat 3433021 cttaactaga ctgaaatatc attacaatat ttttctagaa aatttatctt attttaagga 3433081 ttagcgagag tcaattgacc taaaacaaaa aaaggccgca taggcctttt tacatttttt 3433141 attgtatttg ttcaatatcc gtaccctcag ctgtcacatt cgccttcccc tgcctcctga 3433201 caagcgtcaa ggccatgccc gcaaagatca ttacgatgcc aagcgtttga tagaggtcag 3433261 ggcggaagcc tgtgaagacg gtatcgagca cgatcgcgac agcggggtcg agaaatacaa 3433321 tgattgaaat aaatttcgtt gataaaaatc gtaaactgtc aaaaaacagc aaatatacaa 3433381 tacccgtatg gatgatgccg gtagatacca ccataatcca gtttccctga gataggtccg 3433441 caaaagcgcc aaagtgaata aacggaatca ggatgataac ccctaaacct gtctgcaaga 3433501 aggtggtcgt gtaaggactg agattgtgaa tgccttttcc caataaagtg gtgaacgcat 3433561 aaaacagtgc ggcgagaact gcccatatga tccctgatcc catcagctgt gtcaatgatg 3433621 tgctgccgtt aatcccggaa atcagcgcag tcccaagaaa gcagatgata atggagctga 3433681 cggagatcac atttaatttc tctctgtaga agaagctccc cagaagaaga acaagcaccg 3433741 gcgctagatg ataaacagag atggcaattg taacggacgt ttcttcaaaa gacttaaata 3433801 agaacaccca gttgaataca agaaagaaac cgcacgccaa tgtttgcagc acgtctctct 3433861 tgctccattt ttcagtttta tactggccgg acgccagcca gcaaaagcct aaaaacagcg 3433921 tcgcgcaaag gcagcggaca aagaccaatt caaatgacgg cagattggta tgctctgaga 3433981 aaaagccgat ggagccgaaa atcaccatag agatgaccat tttgattacg gctgttgatt 3434041 tttgttttga cgatatggaa ggatcctgtt gcatcaaacg tattctacct ccaatactgc 3434101 atagcataaa ctgttttttg tgaattcaga aatctacaca tagaattcct cttttttaca 3434161 tgtagatatt ataacacttc tattctaaat aaaaaaaagc gcccaagggc gcttttttta 3434221 caaatctatc gaacaatcaa aaccgggcat gttgataatt gagacacttt atggctgacg 3434281 cttccaagca tcatttcttt caggccgctg atcccccggc tgccaactac aatcaggctg 3434341 acgcctttct cttttgcgtg atttagtatc tcatgcgccg gctcgccatt cgcgtaaatg 3434401 gtttcagctt gaacgccttt ttcggctgct ttttcttttg cattctcaag gattttcagg 3434461 ccctcttttt taacctcgtt cctgatttca tcaataaagt gttcaggcac atagacaatt 3434521 cccgtcagag aagaagtcgt gacgacggct tctctcccca catgaagaat gcttagttcc 3434581 gcttgttgct cttttgccaa atgcactgcg gcatcaagcg cttttgcact catgtctgat 3434641 ccgtcaatcg ctactaacat tttgttaaac atgctcttcc cgcctttcgg actgtgggtg 3434701 gttcatcttt ctcttttatt gtccgcctgc atttcgttat tgtcaattga agcgcatgag 3434761 ttttcaaaaa attgtcagag actctctccg tttgtggcga taacctgctg ataccagttg 3434821 aagctttttt tcttgatgcg gttaaatgtt ccatttcctt cattgtcccg gtctacataa 3434881 atgaagccgt agcgcttttt catttccgca gtagatgcgc tgacaaggtc aattggcccc 3434941 catgatgtgt atccgattaa ttcaacgccg tccgcaatgg cttcgcgcgc ttcaattaaa 3435001 tgatcacgca gatagttgat tctgtaatcg tcctgaatcg tgccgtcctc ttcaaccttg 3435061 tctacagcgc caaggccgtt ttcaacgatg aacagcggct tctggtaacg gtcgtataag 3435121 gtgttgagcg tgatgcgcaa gcctttcgga tcaatctgcc agccccattc tgatgatttg 3435181 aggtaagggt ttttgactcc gcccagcagg ttgccccctg attttgcaag ctcttccgga 3435241 tctgtgctcg ccgccatcga catgtagtag ctaaatccaa tataatccac cgtatgttct 3435301 ttcaagagct cttcatcgcc ttcagccatt tcaatttcaa tattgttttc tgccagatag 3435361 cgtttcatat atcccgggta tgcgcctctt gcctgaacat ctgagaagaa aagtgttttg 3435421 cgctcattct ccattgccgc gaagacatcc tccggcttag aagtcatcgg ataggttgtc 3435481 gttgccgcta tcatacagcc gattttcgaa tcaggaatga tgtcgtgacc cgctttgaca 3435541 gcaagagcac tggccacaaa ttggtggtgt gccgcctggt acatcgcgtt taatttgttt 3435601 tctccttctt caaaaacaag accgcctccg gtaaatggcg catggagcac tacgttaatt 3435661 tcattaaacg tcatccaata cttcactttg tgttgatagc gtttgaaaac cgttttggca 3435721 tagcgttcat aaaactctat gactttgcga ttcttccagc cgccataatt tttcactaaa 3435781 ccgagcggca tctcataatg agagatggtt acgacaggct caatatgatg ctttaacagc 3435841 tcatcaaaca gatcatcata aaatctgagg ccttcttcat tgggctcctc ttcatcgcca 3435901 ttcggaaaaa ttctcgtcca cgcaatcgat gtgcggaacg ccttaaatcc catttctgca 3435961 aataaggcga tatcctcttt ataacgatga taaaagtcaa tcccgttgtg atacagattc 3436021 aaggaagtca ttgattcatc aaatggagac atgatcccgt tcggcgatac gtcagctgtc 3436081 gaaagcccct taccaccctc gttataagca ccctccactt ggttggcagc aactgcgccg 3436141 ccccataaaa atccttctgg aaatcgtttt tcatttgaac tcatattgat caccccatta 3436201 gttttttcaa gataaagcaa gcagcgcttc ttttggctgc actttaccga tctctttcac 3436261 cggcgaaaac gaatattggt ctgtgttggt cacaatcacc ggggtaatga cgtcatatcc 3436321 cgcggctttg atttgctcca gatcaaagga cacgagcgga tctcccggtg cgaccttgtc 3436381 gccttctttg atgtgagccg tgaaccattg tccctccagc tttaccgtgt ccaatccaat 3436441 gtgtatgagt atttcagctc cctgatcact cgtaatgcca attgcgtgtt ttgttttaaa 3436501 aatggtggta acgcttccac gaacaggcga aacaacttct ccttcttcag gctcaatggc 3436561 aaatcctttt cccatgaccc cagcagaaaa cactccgtct ttgacttcac ttaaggcttt 3436621 cacttctccc ttaatcgggc tgtgaatgat ctctctgctg ccttcatgca ctgccggctg 3436681 ctggctgccg tcagaaggca catcctcgaa tccaagcaaa tacgcagctg ctgttcccgc 3436741 cgcaaacgca atcacaaggc cgatcatcgc gtaaataaac gttgggccga taaagacagg 3436801 gatgctcggc agacctgcat tccccccgac gatataggaa gcaacacccg tcatgccgta 3436861 aaacgcgcca ccggctgcac cgccaatcaa agcggccgca aacggctttt tcaatcgcat 3436921 attcacgccg tacatcgcag gttctgtgat ccccatcagc gccgtgatgc ttgtggtaag 3436981 cgcgagtgat ttaaattttt tgtttctaga gcgaaggaag acggcaaatg atgctcccgc 3437041 ctgccccata ttcgccaaaa acatagccgg cagtaaataa tcgtggccgt tttgagcgat 3437101 gttgttgatc atgatcggca caaaggcata gtgcatgccc gtcataatga ttaaagagaa 3437161 tgtacccgcc agcaaaatca ttgccacaag ccctgcatga tcaaacaaat aattgacccc 3437221 agaagacaag tattctccta aaatagcgcc aagcggaccg actgtaatca atgtcagcgg 3437281 cacgacaatc aatagcgtga atgtcggaac cacaatcaat ttgagagatg cgtgtgtaaa 3437341 acggtcaatc catttttcca cgtatgaagc aatccaaatc gacagcaaaa tcgggatgac 3437401 cgttgacgaa taagtggcag cggttacagg aagcccgata aaggaaatcg gtttccccgc 3437461 accgagcagg gctgtcaaat ccggatgcag gatcgccgcc gcaatggcag ccgctacgta 3437521 cggattgctt ccgaattttc tcgccgcact catcgctagc aggagcggca ggaagtagaa 3437581 cgcaccgtca ccgacagccg tcaaaatgac atgaacctgg ctcttctccg ccatccagcc 3437641 aaacgtgact gccagcgcca caagtccttt gatcatcccc gctcccgcaa tcgcaggcag 3437701 aataggggta aacaccccag aaatcacatc aaagaccgca ctcagcacat tctttttctg 3437761 agaggatgaa ccagcgctct tttcatcact gagattgctg tgccgcacaa tcgcctgata 3437821 caccttcggc acatcgtttc cgataatgat ttgaaactgc tcgccgctga tattggtgcc 3437881 catcactcca ggcagctgct ccagctgact gcgatccgcc ttcgcgttgt catgaagatt 3437941 aaaacgcagc ctcgtcatgc agtggatcac gcgctgaacg ttttcttcac cgcctacgag 3438001 ttgtaatatg tccttcgata atttatcata atccatgtgt atacctcctt tttatggggg 3438061 gactgctgga tgaaaggtgg ccgcctttca ccagcttttt ttgtatcaaa tgctgcatca 3438121 cctcctaaaa gagaataaaa aaacctaaat gacacagatt gcgagagtct cctcctgcac 3438181 ctgcaccatt taggttttgc ctgctttcgc agtaacaatc ctgacgggtc gttttatttg 3438241 tttgtaggta tactttagca ctagattcgt gagatgtcaa cgctttcatt tttggtgttg 3438301 actatcgttt ctagaacaaa agtaatcata aagatttgaa cttagtatta acttcaataa 3438361 aaaattattg taattaaaaa ccttgaaagg cattttttcc aatcaaggtt atgaatcgtt 3438421 accgtttaaa tttttttaaa gacttcttta tctgtactat tacattcttt agccaatcta 3438481 ttggttctaa attaaacgca ggaagataca cgccatctgc gcaagattga atgtaatcgt 3438541 ttttcttatt gtctgaatgc tcactttcaa taaaatccgt taaaaagaca atagcatcct 3438601 ccaaatattc cttactttcc tctattaata actcttgtat agcgtcatca ggagtttcaa 3438661 tatcttgatg gaatgttcca gctaaaaact gaaaaacagg gtccttctgt ttattgatca 3438721 ataacatgtc atcttgctcc tttaagggag aggtaacggg ataatgttaa aatcattcat 3438781 catctaataa atcaagataa tactgatcat tctcttctat ttttcttaag aactcggtaa 3438841 gagaagttgc aatttgaata tcataatagt aaatcggatt tttattatta tcatttaatt 3438901 caattgacat taatgccgat tcactacctt caaaaaatat taatttatca ttctcaaact 3438961 catcatatat ttctatgtca ggataaaatt caaagtcatt tatcctcaat cgaaagtctc 3439021 ttacagaata tggatccaaa atgcgattag tattaaactc tgatccttta ataaacccat 3439081 agccaacttc taaataaaaa ttcactaatt cactaggtaa ttttaagttt aaattttttt 3439141 caacctcttc aatctcactt tgattcactg gataaaaatc attttctttg tttgatttta 3439201 taaaattata actcattttt ttttgcctcc tttaaataat tcatttgctg gtgagcctgt 3439261 accatgaatc ccagcttgat gctcgttagg aaattttgct ggatgcatat tccaccattc 3439321 atgttctccg ccaaaagtat tttcaattat atggtgagca tcatacttat cccctttttt 3439381 tctaataatt ttacctgttt tttcagatac aacattttcc ttataaacag gccatttttg 3439441 tccagtgttt tcttcccatt cttttataac tttatttttt actttatcaa atttagtcct 3439501 gtgttttgca gtctctattg gtgacatttt tttatattct ttatttctta atgcttcctt 3439561 taatttatct atttgatttt taggtaattc tctacctgtg cgttgttcta tatctctagc 3439621 atactttttt attaaatcag aattaatttt attagcagat ccacttacat cattcgcaat 3439681 tttcccttta tccttagcaa cgtttttaac ttccgaagcc ttcttagcct ttttcccatt 3439741 attaataagt ttattaatat ctattaactt ttctaactta gctattttgg caaatggtac 3439801 tgagtttatg gaggcaacaa cacggtcttt ccctgtgact ttttcgcctg ataccggatc 3439861 tctgcccgtg gctgctttaa atagatcata cacgccggta agttctacag ccgtctctaa 3439921 aattttcaca tatccattct catccacttt aatgtccgaa agcgagacga caggttcaag 3439981 cttcatgtca ttaccagata tgtatacatt gtaaagtgta tcattataaa cgacttgctt 3440041 aacctctgca tttgagaaat cagtttttat atgttctcta tgttcactcg tattatacac 3440101 tttaccattg ataacgatga tatttttact taccttttta gaatcacccg ttttgacaac 3440161 tgaatccact ttagactttt cattctcggc taatttcttc agcatcatct ccatcggtga 3440221 atcatccgcc tgcttcattt gcgggttaat cgcgccgaag atttggttga tgttttcttc 3440281 ttcctgtgat ttcaggatgg agccgctttt gtagcctgtg atttcaattt tcgggccggt 3440341 gtacatggtt tcgagctgat caatgtattt tttcatcgtt tgaaaatctg attttgcggc 3440401 ttctagtgct tgggtttgct ggccgtcaaa ttgaaagagc ttattcaggg tgtctgaaat 3440461 cagccgctca gcctgttctg tttccatccg aaaaaaggaa tcattgactg tcggcaggct 3440521 gacgatgtga tctatggctg atgtctggcg attgactgcg tcagtgagct gctctgtcac 3440581 ttctcgtgca tgcttgaccc catgtctcgc atcgtgtgag agaaaagcct ctgcgatcat 3440641 gccgtgggag ttagattcta cagaggaaat cgcatgctgt gtttgtttca gcactttttt 3440701 gtattcgtcg ataaatatgc caaagaaaag gagaaaaggc ttgtggcact cctcgtaaaa 3440761 ggtccggatg gcatctccgc cttttccttt cagcgcatcc ttcatgcctg ccagatgctc 3440821 aacgcttttt tccagcttct ccagctgttg tttttgcttg tccagtttct caatcgtatg 3440881 ctgaatgccc tcgtgaagag cgtggacatc taatgttttc aatcccttgt cctcccgcgc 3440941 tttatttcat ggaagatgat atgttttcgt ccgtttcctt catggcgttt accgcgcttt 3441001 ccgtttgtgc gatatgcttg gccagaacag acgcatatgc ttcagtgagc tctttgatgt 3441061 ccttatttaa ttgctcgatg gacttcacaa cattcaaatg gtttctgcct gagagatgac 3441121 cgggcaatga ggacttgagt tcagctgaat tcttgagctg agaaagccct tgcttcactg 3441181 tgtcatacac cattttaatt tcctgtgcca tttgtgctca cctcactttt tatgtttttc 3441241 cttctctatt tcatgctcta tcctcgtgat ttggcgtctt atagaataca catcgccctc 3441301 taatgagtgg atttttcctt ctatgctttc gatgattccg ctgacttgat cgcttttgat 3441361 ttgctgatat gctttgttca ttccttcacg aatatcttca aaccgctcag catgtgttcc 3441421 tctccatgcc tcccggttaa gatgaggccg gtgaatgaga tgctgggcct cagagaaatc 3441481 gtgtttgatt tgcctaattt cgtgcagcac tcgttttaat tgatggatct gttcctgctt 3441541 ttcatgtaag tcggctttta ccgaatgtaa caacatttca ctatgcatgc cgcaacacct 3441601 cgtgtttcta tcaaactgtg taaattcttt acaatacaga ctattttcat attacatgat 3441661 gggtcatatt ggataaatag gtaaaaagga ttgtcttgag aggtatagaa ctggttctaa 3441721 attgctaaaa atacgatctc atcaccctat gaaaggagaa aacaatcata gtagggactt 3441781 tttatttaag cctttaatct ctcctccagt tctaattttt cctcccactt aactgtttct 3441841 tatagtcaat aaagctcata aaaaaacacc ttccctcgaa ggcgcttctc catcttattt 3441901 agatccccat acagcctcac cgctggtatt cagcacacta aacgtcatga cgttcttctc 3441961 tctcaccgaa tcccactggc gtaaaaatac cccgttatac ttcttgcctg ctaacgtgat 3442021 gtcggcggtg ttttttccgg ttttcctcca tgttccggtc atttccccgg aaatggtgtg 3442081 gtttttgttg agctggatgt tgatggtttg tttgatgtcg gctgagatgt cttttccgtg 3442141 ctggataagt ttgtatgttc ctgtgatgtc tttttgtttt acttctttca atgtttcgcc 3442201 cgcataacga tatggtgctg ctaccggcca gccgtctttg ttcatgaaca attggtggac 3442261 tctgacttcg tgttcttcac ccctgcccgg gaagcgggtg tggaagatta aataggaacg 3442321 cccggttttt tcatcatagt atgcggagtt gtggcctggt gagacgtacc cggtgccttt 3442381 ttcattttct gtttcaaaag tgtagctgcc catgagtttg acgccgtatg gttcgatgga 3442441 acggtcgtcg aagaatgtgc ctcccttgcc gcggacgtcg agcattggat tgccttctgc 3442501 atcatagtaa gggccgtccg gtttcttgga gcgggccaca cggatgttgt agccgcctgt 3442561 tgcatcgaga ccgccatatg ataggtataa gtagtagtat tgggtgtctg gattgtagag 3442621 aacatacggg ccttcgattc tgctgtggtt gccgccgagc agttttttcc catatccctg 3442681 tccaggaagc gggaagcccg ttttcggatt catttcaagt atgaaaatgc cgcctgagta 3442741 tgatccgtac accatccaca gcttgccgtc tttatcaaag aaggtatgcg ggtcgacgac 3442801 attcggatgt ttggttgcat catacggtgt tccatcgctg cttgtgcctt ccattcctga 3442861 tttcaaaaag atgcctttgt ttttgtatgg gccttcgatg ttgtcagcaa cggcaacacc 3442921 catggcggat cttggcgaat cgccgcggca ggcgttgtag tacatgtagt atttgccgtc 3442981 cgccagctgc gtgacgtcag ccgcccaaag agtatcggat tgcgcccatt cgaaggtttc 3443041 ttttaattct tcatagacat tcgggataag tgggttgtca ttgcttacgc tggtggtcag 3443101 ctgctgccat tgcatgaggt cattcgattt agctgaagcg agatgagatc caaaaacata 3443161 aaaagtgccg tttgtttcaa tgatggaagg gtcatggacg ctgacttctt taaatatagg 3443221 tttttgtgca tagacggagt ttgggagggt gaaggccatg ataagagctg caagaaaaca 3443281 tacacggaac aatcggttga acatctaaac aattcgcctc tcttttttat taaattttaa 3443341 acgcttacat ttctctatga agataccccg gcctattaaa acagccgaat gttttcatat 3443401 tcatccagat aggtgatttc tcacttcact tacatagtca gactgatgtc tgtctgtttt 3443461 gcgcagaact tgttgcttgc atatcctctc cttcatagtt caactctttt gctgtttctc 3443521 cttcttgcat cacgtctgtt tttctttcgc gtacatgtaa taactgcttt gtcaggtttt 3443581 gcatcaactg tgatacagcc atttcgttgt cggcgttttt taagatgatg cctgattgcc 3443641 cgtcaacacc agagtcattc ggctggctct ttataaaacg ccttgcgaaa aatacgactt 3443701 agtaaacgca tattgagagt tagacagcgg cgcttgcctc cttgtctgga tatcgtgtgc 3443761 aatcgctgaa aaaacctgtt ctgctttctg cgtcacgcta ttacaatagc aatctaactt 3443821 gttaaagact ataaaaaaac cttttgactt ctgctgctga accaattaat ataatactca 3443881 gttaatagtt atcagaattt ttaggaattg agtgattcat atgacactgc ataaagagcg 3443941 tcggatcggc cggctgtctg ttctcctgct gctgaatgag gcggaagaaa gtacgcaggt 3444001 tgaggagctg gagcgagacg gatggaaggt ctgtcttggc aaggtaggat caatggacgc 3444061 acataaagta gtagccgcaa ttgaaaccgc ttccaaaaag agcggtgtca ttcaatctga 3444121 gggttatcgg gagtcacatg cgctttatca tgcgacgatg gaggctttgc atggcgtgac 3444181 cagaggtgaa atgctgctgg gatcgctgct tcggacggtg ggattgaggt ttgccgtttt 3444241 gaggggaaat ccttatgaaa gtgaagcgga aggcgattgg atcgctgtct cgctttacgg 3444301 aacaatcggg gcgccgatta aaggtcttga gcatgaaaca ttcggcgttg gaattaatca 3444361 catatgaaac agcccataga tcttagacga tagggggcta tgcgtgaaaa cagaagttca 3444421 cagcatagct cctttttgta tgggcgcttt accaaagtaa agaaaaagga gttgggctta 3444481 tggtgacttt agacggttct tcattgacaa cagccgacgt cgctcgtgtg ctgtttgatt 3444541 ttgaggaggc agcggcttct gaggaaagta tggagcgcgt gaaaaaaagc agagcagcag 3444601 tggaacggat tgtacgcgac gaaaagacaa tctacggcat caacaccgga tttggcaaat 3444661 tcagcgatgt cctgattcag aaagaagact cggcggcgct gcagctgaat ttaatccttt 3444721 ctcatgcctg cggagtcggc gacccttttc ctgagtgtgt ttccagggca atgctgcttt 3444781 tgcgcgccaa tgcgctgtta aaaggctttt ccggtgtacg cgctgagctg atcgagcagt 3444841 tgcttgcttt tttaaataaa cgcgtccatc ctgtcatccc tcagcaagga tcacttggcg 3444901 caagcggaga tctggcgccg ctttcccact tggcgcttgc gctgatcgga caaggagaag 3444961 tcttttttga gggggaaaga atgccggcaa tgacaggctt gaaaaaagca ggtattcaac 3445021 cggtaacgct gacatccaag gaagggcttg ccttgattaa cgggactcag gccatgactg 3445081 caatgggggt ggtcgcctac atcgaagctg agaaactagc ctatcaaaca gaacgaattg 3445141 ccagcttaac gattgagggg ttgcagggaa ttatcgatgc atttgacgag gatattcact 3445201 tagcccgcgg ctatcaggag cagatcgatg tcgcagaacg aattcgcttt tatctatctg 3445261 acagcggcct gacaacctcc cagggagaac tgcgggtaca ggatgcctat tcattgcgct 3445321 gtattccgca agtacacggt gcgacttggc agacactagg atatgtcaaa gaaaaattag 3445381 agattgaaat gaacgcagct acagacaatc cactcatttt caatgacggt gacaaagtga 3445441 tttccggcgg aaactttcac ggacagccaa tcgcctttgc catggatttt ctgaaaatcg 3445501 caatatcaga gcttgcgaat atcgcagagc gtaggatcga acgacttgtg aatccgcagc 3445561 tgaatgacct gccgccgttc ctgagccctc atcccggtct gcaatccggt gcaatgatca 3445621 tgcagtacgc cgcggcctca ctcgtttctg aaaataaaac actggcccat cctgcaagtg 3445681 tggattccat tccgtcatcc gccaaccaag aggaccatgt cagcatggga accatcgccg 3445741 ctcggcatgc ttatcaggtg atcgcaaata caaggagagt cattgcgatc gaagccattt 3445801 gcgcattgca ggctgttgaa tacagaggca tagaacatgc agcgtcctat acgaaacagc 3445861 tttttcaaga aatgagaaaa gtcgtgccgt ccattcagca ggaccgtgtt ttttcctatg 3445921 acattgaacg cttgactgac tggctgaaga aagaatcttt aatacctgat catcagaata 3445981 aagaactaag ggggatgaac atatgactga tgtaaaaaaa tcaatccgtg ccaacagagg 3446041 aacagagctt gaatgcttag gatgggagca agaggcagtg cttcggatgc ttcgaaacaa 3446101 ccttgatcca gaagtcgccg agaagccgga ggacctcatc gtatatggcg ggattggcaa 3446161 agccgcacgg gattgggacg cttttcacgc cattgagcat tccttgaaaa cattaaaaaa 3446221 tgatgaaaca ttgctcgtgc aatccggaaa gcccgttggc atgttccgta cacacccgca 3446281 ggcccctcgc gtgctcctag caaattctgt tcttgttccg aagtgggcag actgggagca 3446341 tttccacgaa cttgagaaaa aagggttaat gatgtacgga cagatgacgg ctggcagctg 3446401 gatttacatt ggctcacaag gcatattgca aggaacctat gaaaccttcg ctgagctggc 3446461 gcgacagcac ttcgggggca gcttaaaagg aacgttgacg ctgacagcgg gtctcggcgg 3446521 aatgggaggc gcccagccgc tgtcagtcac gatgaatgaa ggcgtcgtga ttgccgtcga 3446581 ggttgacgag aaacgcatcg acaagcggat cgaaacaaaa tactgcgatc gaaaaacagc 3446641 atcgattgag gaagccttag cttgggctga agaggcaaag ctggcaggaa aacctttgtc 3446701 cattgcactt ctcggaaacg cagctgaggt gcatcacaca cttttgaacc gaggcgtcaa 3446761 aattgatatt gtgacagatc agacatctgc ccatgaccct ttaatcggtt atgttcccga 3446821 gggctattcc cttgatgaag ctgaccgttt gcgtcaagac actccagagc tttacgtgcg 3446881 ccttgcgaag caaagcatga aaaaacatgt cgaagccatg ctggcctttc agcaaaaggg 3446941 ctctattgta tttgactacg gcaacaatat ccggcaagtc gcaaaggatg aagggctgga 3447001 gaatgccttc gattttccgg ggtttgtccc tgcctacatc cgccccttat tctgtgaagg 3447061 aaaagggccg ttccgctggg cggcgctttc cggagatccg gcagatattt accgtacgga 3447121 tgcgttatta aaagagctgt tcccgacaaa taaagccctt caccgctgga ttgatatggc 3447181 acaggaaaaa gtcaccttcc aaggcttgcc gtcccgtatc tgctggcttg gatatggaga 3447241 acgaaaaaag atgggcctcg ccattaacga gctggttaga accggggagc taaaagcgcc 3447301 tgtcgttatt gggagagatc atttggactg cgggtctgtc gcctctccaa accgggaaac 3447361 agaagcgatg aaggatggaa gtgacgctgt cggtgattgg gctgtgctaa atgcgcttgt 3447421 caacacggcg gcgggtgcaa gctgggtttc cttccaccat ggcggcggcg tcggaatggg 3447481 ctattccctt catgccggca tggttgcagt ggccgatgga agtgagctgg ctgacgagcg 3447541 gctcgcgcgg gtcttaacga gcgacccagg aatgggcatt atccgtcatg cggatgcggg 3447601 ttatgaacgt gccgttgaag tagcgaagga acaggacatt atcgtgccga tgcaaaaata 3447661 aaggagtgat gacatgccaa agcaaattga tacgattctc atcaacatcg gtcagctttt 3447721 gacgatggaa agcagcggtc cgcgggcagg caaaagcatg caggatcttc atgtgatcga 3447781 agacgctgtt gtcggcatcc atgaacagaa aattgtgttc gccggacaaa aaggggctga 3447841 agccggttac gaggcagacg aaatcattga ctgttcggga cgccttgtaa cgcctggcct 3447901 cgttgatccg cacacccatc ttgtatttgg cggatctcgt gaaaaggaga tgaaccttaa 3447961 gcttcagggc atttcatatt tggatattct ggcgcagggc ggcgggattc tgtctacagt 3448021 caaggatacc agggcggctt cagaagaaga gctgctgcaa aaagcccatt ttcatctgca 3448081 aagaatgctg tcctacggca caaccacagc agaagtgaaa agcggctacg gcttggaaaa 3448141 agagacagag ctcaaacagt tgcgtgtcgc aaagaaactg catgaaagcc agcctgttga 3448201 ccttgtttcc acatttatgg gagcccatgc gattcctccc gaatatcaaa acgatccaga 3448261 tgattttctg gatcaaatgc tttccctttt gccggaaatc aaagagcagg agctcgccag 3448321 ctttgctgat atttttacag aaacaggcgt ttttacagtc agccaatccc gccgttattt 3448381 acaaaaagca gctgaggcag gcttcggatt aaaaatacac gcagatgaaa tcgatccgct 3448441 tggaggtgct gaattagcag gtaagctaaa ggccgtctca gccgaccatt tggtaggtac 3448501 atcggacgaa ggcataaaga aattggctga ggcaggaacg atcgccgtcc tcttgccggg 3448561 cacgacattt tatcttggca aaagcacata cgccagggca agagctatga ttgatgaagg 3448621 tgtatgtgtc agcttggcaa cggattttaa tcctggcagc tcgccgactg aaaatatcca 3448681 gctgattatg tccattgccg cgcttcatct gaaaatgact gcagaagaaa tatggcacgc 3448741 ggtcacagtc aatgccgcat atgccatagg aaaaggagaa gaagccggtc agctcaaagc 3448801 tggccgctca gctgatcttg tcatttggca agccccgaac tatatgtata ttccgtatca 3448861 ctacggggtc aatcatgtac atcaagtcat gaaaaatgga acaattgttg tcaacaggga 3448921 gggagccatt cttggataag tacccttttc tcagagaggc cggatcttcg tttaaagacc 3448981 gggatgtcac aaaaatgagc gacctgatcg caacatggga cggccaggac attaagggac 3449041 cggcgttgat aggtgtcccc ctatcaaaat cctccatcag tcattcaggc gcttcctttg 3449101 cacccggaac aatacgccag gctctgaaac attcatcagc ctattctgct gagcttggag 3449161 agcacgtcgt atcagagctt ctatatgacc tgggggatat cgatattcat gtcactgata 3449221 tcgtaaagtc acatcatcac attttccaaa ccatgcacgc tctgctttcg gatcatccgg 3449281 attgggtgcc gctcatactt gggggagata actctatcag ctactccaca ataaaagcga 3449341 tagcacaaac aaaaggaacg acagcggtga ttcaatttga tgcccatcac gatgttcgca 3449401 atacggagga cggggggccg acaaacggca cccccttccg ccgccttttg gatgaagaga 3449461 tcattgaagg tcaacatttg atccagctgg gtatcagaga attcagcaac agccaggcct 3449521 atgaagcata tgcaaaaaaa cataacgtga acattcacac gatggacatg atccgggaaa 3449581 aaggactaat cccaacgata aaagagattt tgcctgttgt tcaagataaa acagatttca 3449641 tttttatatc tgttgacatg gatgtcttag accagtccca tgcacccggc tgtccagcga 3449701 ttggcccggg cggcctctat acagacgaat tgcttgaagc agtcaagtac atcgcacaac 3449761 agcccaatgt tgccgggatt gaaattgttg aagtcgaccc taccctcgat tttcgagata 3449821 tgacaagcag agctgcagct catgttctgt tacacgcatt aaaaggaatg aaactctccc 3449881 cattcaagtg atcttctggc aggttgtatt ttgggtataa gaaactcatc tgcctaagga 3449941 atggcagcta aaaggagggc gagacagtga atcttcagga gaacagcagc caacagctaa 3450001 aacgcacaat gaaaagcagg cacctattta tgatctcatt gggaggcgtc ataggcacag 3450061 gacttttcct cagtacgggc tatacgctac atcaagccgg acccggcggt acgatactcg 3450121 cttatgtaat cggcgggttg atgatgtacc tcgtcatgca atgtctcggc gaattgtcgg 3450181 ttgccatgcc ggtgaccggc tcttttcaaa aatatgctac aacatttatc ggtccatcta 3450241 ccggttttat ggtcggcatc atgtactgga tcaattgggt ggtgacggta ggctctgagt 3450301 ttaccgcatc cggtattctc atgcagcgct ggttccctga cagcagtgta tggatgtgga 3450361 gtgcgatttt tgcagccctt ctttttatat gcaacgcatt ttcagttaag ttatttgcgg 3450421 aaactgaatt ttggttttcc agcgtaaaga ttgtcaccat tattttattt atcattttag 3450481 gaggagccgc catgtttggc ctgatctctt taaacggaac ggcggatgct cctatgttgt 3450541 caaacttcac agatcatggc gggttgtttc caaatggctt tctcgccgtt tttatcgcga 3450601 tgatatctgt gagcttcgcc ttttccggta cagagttaat cggcgttaca gcaggagaat 3450661 cagcaaatcc tcaaaaggat ataccgcgat ccatccgtaa tgtcgcatgg agaaccgtga 3450721 tttttttcat tggcgctgtc ttcatattat ccgggttgat ttcatggaag gacgcaggcg 3450781 tgattgaaag cccgtttgtc gccgtatttg cggagatcgg aattccttac gctgctgata 3450841 ttatgaattt cgtaatatta acagccttgc tgtctgtcgc caactcaggc ttatatgctt 3450901 cgacccgtat gatgtggtct ttagcaaatg aaaacatgat cagctcccgt tttaagaaag 3450961 tgacatctaa aggcattcct ttaaatgcct taatgatcag tatggctgta tcttgtttat 3451021 ctctcgtttc cagtatcgtg gcccctggaa ctgtctatgt ggtgatggtc gcaattgctg 3451081 gatttgcagg agtcgtggtc tggatgagca ttgccttgtc ccaactcttg tttcgaaaga 3451141 gatttttgaa aaaagggggg gatgtaaaag atctgacatt tcgcacgccg ctttatcctc 3451201 ttatgcctat agccgctctc ttattatgtt ctgcttcttg tatcggtctt gcttttgatc 3451261 ccaatcaaag aatcgcactt ttctgcggag ttccttgtat catcctttgc tatctcatct 3451321 accatttcaa aagaaatgtt acaaaagcga aaaaaatcag ccaagaggaa tatccagccg 3451381 atcacatcct ataattaaaa aagcacaccc cgctcagcat gggatgtgct ttatttttta 3451441 ttctgtaatt aacgtatgaa tcagcttcgg cgccttcgct tccgcggcga tgcggatgtt 3451501 gtcatagact tttgcgatga cttcatcgac gttttctcgg ttagcgtaaa gcgttacgag 3451561 cggttcccct ttttctactt tgtcgccgac ctttttgcgg agcatgatgc cgacggctaa 3451621 atcgatttcg tcttcttttg tggcgcggcc ggcacctaac agcatcgccg cgacgccgat 3451681 ttcgtccgcg acgatttcag agacgacacc cgcttctttg gcaggcacat caatttgata 3451741 tgcggcttgc ggaagcttag acggatcgtc aacaattgag ctgtcgccgc cttggttttt 3451801 caggaaatcc ttgaatttct caagtgcttt gccgtttttc atgacttctt ccagcttcgc 3451861 tctcgcttcg tccaatgtat cggctttttt cgcaagcaca accatctggc tgccgagcgt 3451921 taagacaagc tcatgaagat cctcaggccc ctcgcctttg agcgtgtcga tcgcttcttt 3451981 gacttcaagc gcatttccga tcgcaaagcc gagtggctgg gacatgtctg aaatgacagc 3452041 cattgtttga cggccgacgt tatttccgat gcgtaccatc gctttggcaa gttcagctgc 3452101 gtcttcttct gttttcatga aggcgcccgc tcccgttttt acgtcaagca cgatggcgtc 3452161 cgccccggca gcgatttttt tgctcataat cgagcttgca atgagcggaa tggaattgac 3452221 cgttcccgtt acatcacgaa gcgcgtacag ttttttatca gccggcgtta aattgccgct 3452281 ttggccgatg accgcaacct tgtcgcggtt cacaagttta ataaattcat ccttcgtcag 3452341 ttccacgtgg aagcccatga ttgcctctaa cttatcaatc gtgccgcccg tatggccgag 3452401 gccgcggccg gacatcttag caaccggcac atcaagagcc gcaacaagcg gagcgagaac 3452461 gagcgttgtc gtgtcgccga cgccgccggt agagtgttta tccactttaa ttccttcaat 3452521 ggcagaaaga tcaatcgttt caccggagtt caccatagcc atcgtcaagt ccgcgcgttc 3452581 acggtcactc atatcctgga agaaaatcgc catagcaagc gcgcttgcct gataatcagg 3452641 aatgcttcca tctgtatagc cgttcacaaa aaattgaatt tcttcagtgg tgagttcttt 3452701 tccgttttgt tttttgatga tgatatctac cattctcatg tttggtcacc gatccttttc 3452761 gattaagttc agtaaatcaa gcccacaatt gctgctgata aaaagctgac aagcgtagca 3452821 ccgtataata atttcaagcc gaaacgagcg acgacatttc cttgcttttc attcagtcct 3452881 tttacggcac cggcaatgat tccgattgag gagaagttcg caaatgacac aaggaatacc 3452941 gatacgatcg ctgttgtacg gccgctgaaa tggaaaccgt tttgcgtaag cgacgtcatg 3453001 gcgacaaatt cattcgatac catttttgtt gccataatgc ttcccgcatt aacagcttca 3453061 ttccatggga taccgacaag aaaagcgaat ggagcaaaca catatccaag aatgccttgg 3453121 aacgaaatac cgaatactgc attaaaaatg ccattgatca atgcaataat cgcgacaaat 3453181 ccaatcagca tcgcagcgac gacaaccgct actttgaaac cgtcaagaat gtattctccg 3453241 agcacttcga agaaggattg tttttcttct tcctcaacac gaagcatatc ctcttctttt 3453301 gcaacctcgt acggattgat aatagaagcg ataatgaaac cgccaaataa gttcaaaaca 3453361 agcgctgtta caacatattc cggtttcagc attgtcatat acgcaccgac aatcgacatt 3453421 gatacagttg acatcgcaga tgcgcaaagc gtgtacaagc gctgctgatt taaaagaccg 3453481 agttctttct tcaaggagat aaatacttct gactgcccta aaatcgcaga agccactgcg 3453541 ttatacgatt ccaatcttcc cataccgttt accttgctga gggcaaggcc gatatatcta 3453601 atgataaacg ggaggacttt ccacttttgc agaatcccga tcagagcgga aataaacacg 3453661 attggcaaga gaacattcat aaagaatgtc gtttggtccg cattcaccaa gccgccaaac 3453721 acaaagttaa ttccctctgc cgcgtattca agcaggtaac cgaatccttt tgcaaatcct 3453781 cccacgagga aattccctat tccggtattg aggagaatgt agccaagaat aaattgcaaa 3453841 atgagcataa caacaattgg gcggatctta attctttttt tgccgctgct cgcgatccac 3453901 gcgaggccta aaaacacgat taaaccgata atcccaatca aatacttcat atgtgtttct 3453961 cctttatttg tattcgctta caattactgt ttcctcagaa aacggaaagc agtctgcctt 3454021 ccgtcagctc ttaatagttg tctccgcctg atgcattttc tccttttacg atagaaacgc 3454081 ctgcgctggc gccaattcgg cttgctccgg cctctaccat tgtgtctaca tcttctttcg 3454141 ttctgacgcc gccagatgct ttcacgccga tatcaggccc tactgttttg cgcattaagg 3454201 cgatatcttc cttcgttgcg ccgcctgtag aaaagcctgt tgatgttttt acgaaatccg 3454261 ctcccgcaga caccgctaaa cggcatgcac gttctttttc ttcatcagtc agaaggcacg 3454321 tttcgataat gactttgaca agcgcttttc cggctacagc ttccactaca ccgcggatat 3454381 cagcttccac cacatcgtct tccttgtctt ttaaagcggc aatattaatg accatatcca 3454441 cttcagtggc gccttttgaa atggcgtctt ttgtttcgaa cgcttttgtt tcagttgtat 3454501 tggcaccgag cgggaagccg atgaccgtac aaacgtcgac tccagttccc ttaagctctt 3454561 ttgcagcaag ctccacccat gtcggattga cacatactga agcaaatttg tatgttttcg 3454621 cttcttcaat tagttttaga atgtccgctt tttgtgtatg cggtttcaaa gctgtatgat 3454681 caattatgtt ggctaatgac atccttcgca cacttccttt tttgttaaga tattttttag 3454741 cataaccgac ttttgaacat atgtaaattg gtaattgaaa ttttgttcaa tgaaaggttt 3454801 gaacgtgtca caaatcatta acaagcgccc tcgcggtatg ctggtcaatg attaaaacgt 3454861 tggcatattt tccggttaat gctccgtgaa tggaagatac ttttctgctt ccgccggcaa 3454921 ctaaaatgga gcgttccttc agtctaaggt cttgaagctc aacaccgatg gtccggtcat 3454981 tgatggcgct gctgcaaata ttccctttcg catcaaaaaa gcgtgaacaa atatccccga 3455041 cggcctgttt tttcagcagg gctttctctt cttcgttaaa atatccgagc cgaaacaaca 3455101 gcgcttcatc acggacagtc ccgaccgtaa agagagcgat attcgcctgc ttgcccatct 3455161 caatgatccg ttcaatatga cggtctttct ccaccattcg cttcacatcc gcattatcaa 3455221 acacgacggg aagcgggaga tagcgcggca tcgtttgaaa agcctctgca aacagctgaa 3455281 tcgtttcagc cgaatacgtg tttacccggg aatggctgat gccgcctttc agctggacga 3455341 cctcgacgcc ttttacctgc ttcggctgca tgttttgcgc gatttgatac atggtggttc 3455401 cccagctgac gccgacaatg tcgccgtctt ttaccgtttc atgcatatat tctgcaccat 3455461 agcggcttag gtcatgtgta attcctgcat aatcgggtgt cggggaaaac acaacatgcg 3455521 cctcaaggag cccgtatttc tcttcaagta tggaaccgag cgcatccaaa tcctcaaaag 3455581 ggtccatgac gcgaatctgg acataccctt tttcctttgc atattgcagc agccgggaaa 3455641 cggttggcct tgaaatgttg agctgctcag caatttgctg ctgactgtag tcagactgat 3455701 agtaaagcct tgccgcttct atgcttaatt gctgtttttc ccgatccatt ctgcacctcc 3455761 ctgtggatca gtcctgataa aactgctttt gatttgcttt tattatacag gctggcgccg 3455821 gctttcatcc acctgatttc taagaaactg aaaaacgctc tgggcgcgga cctgcccaga 3455881 gcttacttct cccaagtcat atgctgataa atgcctttca taatggcgta cattccatat 3455941 aggatcaggc ctaatgccaa tatagacaga atcaatttgc catgcggctg ctgcgcgagt 3456001 tctgcgagcg cgccgtcaaa gcctcttgtg tcgtcgggat cagcggtcat ggctgtcttg 3456061 atgagaaaat agccgatagc cgagaaaata atggcccggg cgatattgcc tgcgcgtcct 3456121 gtgtttttcg tgatgcatat catctgtttg ttcatttttg atgtatcgaa ttctttcata 3456181 aaagcagccc gaacgccttt cataaattga acaatcgcaa atacgataaa acccgcaccc 3456241 gtaagccctg tgagccattg gccgaacggc tgcgccaata cataagcgga ccacgtctgt 3456301 tctgaagtgc cgccgtcccc ttggccaaac acaaatcgca aggcattcca agcgatggat 3456361 gtgtaaacag cggcactgaa aaagtttcct attctccgcg acaggcctcg cctgctgttt 3456421 ccgtgcccct ccgtgtcctt gatcgcgctt aacaccatcc agatcacata gccgataagg 3456481 ccgatgccta taaaaaaaag caatagtgac ccatacggca tgcgtgatag cgtttggaga 3456541 gctccgctcg aatctttggc gcggcctgcc ccggcagccg tcataaaagc caaaacccca 3456601 agcagaataa aaacgccgcc gaatgcaaaa taaccaagcc tcccgaatcg tttgatccaa 3456661 ggcttggttt cctgttttat ttttgacatg taccggtctt tcaccgccat gtgtccaacc 3456721 ctctttcaca gaaatcttta ctgtaacatt cccgattgaa caaagttgaa acagctcctg 3456781 cctcagctat ggctggctga gatacgtttt tgctgtttag ctgattgtgc aggtgtcatc 3456841 caagcagccg ctgcggcagc tgtgactccg cctgctaatt tcccaatgat catggccgcc 3456901 gccatttctt ttttcattcc agctacaaaa ccgagatggc tgccgagtac aaaggcgccg 3456961 ctgaccgcaa acgcgacatt gatgaccttt cctctcggcg tcatatcctt taatgaagcc 3457021 agcattggga tatgatgcgc caaagaggtc actaagcctg ctgttgctgt ctcatctaaa 3457081 tgaaggcatt tccccagagc ctgaagcggt tttttaaagg tttttgtaat aaatgccgtc 3457141 atcgggaacg cccctgccag agcaatggcg atggtccctg tcgtttgtat ccctgtctcg 3457201 acattctcca ttcccggaat cagcacaatg ccggtcatcg tttcaacaga aacagctgca 3457261 agcccgataa tcgcaaccat actgaccgct ttcccgaaga gatgaaacaa ctgaatcatt 3457321 ctgtcggtgt atcgccataa cccaaaagcg atgacagcag ataacagact cgggatcaga 3457381 agatttttac ctatcatgcc gatgtcaaag cctgcgcata atccgccgat taagcaaccg 3457441 atcggcactg tgcacagccc gattaatatg cctttcgcaa aatacggatg atcctctttt 3457501 tcgatgatgc caagagcgac gggaatcgtg aagacgattg ccggccccat cattgttcct 3457561 aaaaacaccc atgaaaacag cccggcctgc ggatctttcg ccatttctcc agccagcgca 3457621 tatcctccca tatcaatcgc caaaatggtg ttcgcaaagg aagaaggatc cgcgccaatc 3457681 gctgtgtaaa acggagcaac aatgggaatc aagattgctg ccagcacggg cgccagcgat 3457741 acaattccga tcatggacag cgccagcggc cccatagcct taaagccgtc cgcaaaccgc 3457801 tcgcctagcc cccatctgtt tcccaaacaa taatccgctg ctccccatag taaaaaggca 3457861 gccaaaatga atacaaccgc gtcattcacc gtcatggttt tctccttttt caaacgtatg 3457921 attggtttta tcatatcatc tgaaatcacc gaatagagtt gatcttattc aatatgagct 3457981 aaaaattctt ttatatcggc tttttcaacg gctgttataa tgcgtcgcgc tttttcttgc 3458041 gggaccgtta atgtcaattt ttctattatg tcttcttcag acagctcatt tcctggtgcc 3458101 ccttttgggc agtccacacg cgcttcgcaa atccggccgt ctgataaata ggcccggaca 3458161 atcgtgaaac ggccttttgg aacggcatga ggagccggct gaatagcatt gtcatatacg 3458221 cgctgaattc gccccattgt cgtttgaacc ccgtttggga tcggctggct gctgaaatgt 3458281 tcaacggtca ggccgtgtcc atgcaaagca agagcaatca catattcaac gctgaaacgg 3458341 ccttcctctc cagcttttgg agatctttcc gtcaatgcag catctccgcc tggcggaaat 3458401 atcacttcaa tacgttcggt attggcagca gaaatggttt cttcggagat aagctgtcgt 3458461 accgcatctg cagcatggtg tgccgcggaa caaaatggat agattttaaa ccatagaccc 3458521 ggctgcacaa ttctccacgg tgccccccaa tcgtttagca aagtgtgttg tgctttctca 3458581 acgtcaccgt acagactgaa gaaaccagtt tctccatcaa gtgccgtgcg ggacccgcca 3458641 aattctgatt gggccagctt aacggccagc aagccagcct gagccgccaa accggcgtgc 3458701 agcggtttca tttctgttcc aaattgcacc ctcatcccag cagattgcgt agccgcaaaa 3458761 ccaattgctt tttccaactc ttcctgagtc agctcctcag cataacctac ggcgcaggca 3458821 gcagcgatgg caccaagcgt acctgtatta tgccagccct tctcatagtg gcggctgcca 3458881 attgattctc ccagccgtgc catcacttca acaccaacaa cataagcgcc aagaagccgc 3458941 tcgtcatgtc cgcgagcggc agaagcaata agggccggta cgatgactgc actggggtgt 3459001 cctcttacat cggagtggac atcatcaaaa tccaatgcat gggcgataaa tccattgagc 3459061 atcgcggatt gtaatggcgc ggcctttttg ccctgtccga taacaggaac aaggggccgg 3459121 cctccttcat cctctatcag acggaggagc ttttgaattc ctttatcttc tcttcctgcg 3459181 aatgaagcgg cagtaaaatc aagtaatccc ttttttgctt cgtgaatcgc gtcaactgaa 3459241 tgctcaggtt gtgacgttct cacagcctct gcaagacctg ctgtcagccc ttgtttgctc 3459301 atttgatggt ctccaataca ataaccgcca gctccgcaaa gtattgagag gcaaccgtaa 3459361 gggcttcttc atccagtgta aaggccggat gatgccactc ctccgtcccg ttcgttccca 3459421 tccagacaaa aaatcccgga atcttctctt gatacagagc gaagtcttct ccgcccggag 3459481 actgctcagc gtgaacggtt tgatagccaa gccgtgccgc agcttcggat gccgcattca 3459541 aaaatgtgcc gtcattctga acggaaggca aataaggaaa ccacttgaat tctgcttgtg 3459601 ccccatagcc cgctgcaatt ccttcagcca ctcgtctcat atgctcggga acagcctgcc 3459661 tcgcttcttt ttgaaaggtt cgaaccgtcc cctccatttc agcttggtct ggaattacgt 3459721 tccacgaggt gcccgcctgt actcttgtga tactgacgac tgcgttttgc agtgagctga 3459781 tattgcggct gaccacagat tgcagcccgc tgatgatttg tccggctgca gcgattggat 3459841 caatactgtt atttgggatg ccggcgtgcc cgcctttccc tttgatgacg atctcaaatc 3459901 ggtcaacact tgccatgagc ggaccttcct ttacaccaat ggtcccgaca ggcagatccg 3459961 gcttattgtg catgccgaaa atcgcagaaa cgccattaag tacgccagct tctagaacct 3460021 ttcttgctcc tgcggcaatt tcttcggccg gctgaaagat aaagcggact gtacctttca 3460081 gctcggccct tctttgattc agcaacatcg ctgtgccaat aatagaagca gtatgaaaat 3460141 cgtgtccgca cgcatgcatt gtgccatcaa ccttagatgc aaatggaaga ttcgtctgtt 3460201 cttggatcgg gagcgcgtca atgtccgctc gtattgctat cacggggccg tcttcccgtc 3460261 ctttgatttc tgcaatcaca ccagtcttca attgagggac atcaagtatt tcgatttgct 3460321 cctcctcaag ccaacggcgg atttttttcg tcgtttcaac ctcttgaaat gacagttcag 3460381 gatgttcatg aagatcacgc cgcatattga ttaaacgggt atgaaacgct ttgtcggcca 3460441 ttgttcttct ccccttctta tataagctct gcaggctctc ccacctgctt gataaatcgt 3460501 ttcgtccgtt cgtttttcgg atggtcaaac agttcctctg gcgttccctg ctcgataata 3460561 tggccgtctg ccataaaaat cacttgatca gcaacctctt ttgcaaacgc catttcgtgt 3460621 gtaacaatga tcatcgttgt ttgtttttcc gcaatggact tgatgacctg aagcacccct 3460681 gtgacgagct cagggtcaag cgctgacgtt ggttcatcca gcaaaatcgc atgcggattg 3460741 accgcaagcg cccgcgcaat gccgattcgc tgctgctggc cgccggacat tgtgattgga 3460801 tagctgtcag ccttatgctc cagaccgact tgtttcagaa tctccattcc aatacgtttc 3460861 gcttcgtcgc gtggtttatg ttgagccacg attaaagctt ctgtaatgtt ttgcagagcc 3460921 gttttatttt taaacagatt gtagttttga aagaccatgg ccgtttgctg gcgaagccga 3460981 tgtgcttcct tgcgtgtaaa cttttccgca ttcagtttgg cttctccgat ttcaataagg 3461041 ccttgatccg gacgctctaa tagatttaag caccggagaa gcgttgattt tccggaaccg 3461101 gacggaccga tgattgccac cacttctccg cgtttcactt ctagatcgat tccgtcgagc 3461161 acgacgagat ctttaaacgc tttgcgaata ttttttactg ttatcaactg atttcacctc 3461221 taagtccggt atggcttgct catggcacgt tcaaacaagt cctgcaaaat gctgtagata 3461281 atggtaagaa cccaatagac gatcgcaacc gccaaatacg tctcaaaata tttgaggttt 3461341 cctgaagcgt acatcttccc ttgggcgaac atctccatga cccctaatgt aaaggccagt 3461401 gacgtttctt tcaggagccc gataaatgta ttgcccgttg ccggaatcgc atttcggatc 3461461 gcttgcggca aaataatccg tctgtatgcc tgaaattttg tcataccgac agacaggcac 3461521 gcctccagct gcccgtcatc aacagaattg agggcggccc ggaagatttc tgccaaataa 3461581 gctgcgtttt ttaagcttaa cccgatgatg gcagctgtga gagctgtcat tttgctcatc 3461641 tctggaaata gctgcggcag cccgtaatag attaagaaca gctgtacaag tgtcggcacg 3461701 cctcggaaaa aggatatata cagctttgac agctgatgaa gcactggaat tttgtttttt 3461761 gtaatgagtg cgagaataag tcctccgata atggcaaaaa tcatagctgc tattgccata 3461821 aacaaggtga tcggaagggc ctgaattaaa gtcgggaacg ctgatatcat gaattcccaa 3461881 tcaatcgtgt tcattctggt gagtcaccgc cgtttcttaa tgcttctgtt ctactgtgat 3461941 atcttcatta aagtattttt cagagagttt tttcagtgtt ccgtctttac gcaattcatc 3462001 tagggcctta ttgacttttt tgcggagctt gtcgtgcgca tcgtccttgg caaatgggaa 3462061 tgcaacctgt tcgtaaacaa tcggatctcc tgcaagcttt aatggcaaac cggtcttctt 3462121 gatttgcgcg atcaatacag ttcggctgtt gacataagcg tctacacggc cgtacgcaac 3462181 atccttcagc gtaccctctt gtgtttcgta cgttttgata ttgatttttt tatcaggatc 3462241 tttgctttca aggtttttcg cgtggtttga accgagaacg gctgcgactg tcttgccttt 3462301 taaatcgtct actgatttga tgtctgtatt gtcttttttg acgacaatct gtgttcccgc 3462361 ataagcgtat ggtttcgtaa agttatacgt ttccttacgt tcgtctgtca cagctacctg 3462421 gttggaaatg gtgtcaagct tgcctgtttg aagctctccc atcagcccgc tgaattcaag 3462481 cagcttccag tccagtttca tgtcaatttt cttagcgact gcttccatca cttccacgtc 3462541 aaagcctgtc agctttccgt tttctttata agcaaatggg taactttgtc ctgtcgcacc 3462601 gacatgaagc acattgtcat cctctttact gctgctgttt ccattgccgc aagctgagag 3462661 caccgctaat aatgcagcaa cgaccagcac tgtccatttt ttcatcttca tttgattttc 3462721 ccgccttttc tatttttata gatcatgtcg caattgtttt ttcatataga ctgtgatatg 3462781 cccttttcca aggtcttgtt cacctgagcg gacatatcct tttcgttcgt acatctcaat 3462841 cagccacgga tgcttatccg ctgttccgag tgagacaaac ggaaccttta acgtatcgcg 3462901 aaggattgtt tcctccagcc attgaagcag ctttgttccg attccttttt taccggtgtc 3462961 ggggtccaca gcaaaccacc agatatgcgg aacgccatac ggtcccggct gttttcccca 3463021 aggcattctc aaggtgatgg tcgcgatgat ccgcccgtct tcttccatga cgtagcaagc 3463081 attttcccga atatttttca gcaccaaatc caaatccgca tgagcagcag caaaacgaat 3463141 gccgagcttt cgaatcggtt cataagcccg caatgtcagc tcgagaagct gttcggcatc 3463201 acgttcaact gcaaggcggt atcgtggctt catctagcgt tcctccttac tttgcatagc 3463261 ggtttaccgg cttttccaaa ccgaagtgct ctcgtaatgt tgtgccttca tattcttttc 3463321 tgaacacgcc gcgctcctgt aaaatcggaa ccacttgatc aacaaacact tcaattcctt 3463381 ctggaagaag cggaggcatg atgttaaacc cgtcacacgc tttcgtatcc acccattcct 3463441 gcatcttgtc ggcgagctgc tccggcgtgc cgacgaagat atggtggcct ctggagcctg 3463501 caacgtattt gtaaagctct cgtatcgtca tattgtcacg ttcagccatc tcctgaacaa 3463561 gcttgaagcg gctcttcacc gcattggaag cttcggcgtc aagcttcggc agcggcccat 3463621 caagcggata tgccgacaaa tcaattccgc ctaagtaatt ttggagaatt tgcagaccga 3463681 cagatgggat aatcagatct tggagctcct tgtatttggc ttgcgctgct tcttctgtat 3463741 cggcaatgat tgggaaaata cccggcataa tggcaatttt ttctggatca cgtccgaatt 3463801 ccgcagcctg ttctttaatg gattgataaa attcttgagc tgattccagg tggttttgtg 3463861 ctgtgaagat cacttcggct gttttggcag ccagcgcttt tccgtctcct gatgatcctg 3463921 cctggataat gaccggctgg ccctgcgggg ttcttgaaac gtttagaggt ccgcgaaccg 3463981 agaaatattc tcctttgtgg ttcagctcat gcattttttc tttgtcaaag aattcacccg 3464041 tttctttatt acggataaag gcgtcctctt cccatgaatc ccaaagcccc tttacaatct 3464101 cgacaaattc ctctgcccgc tgatagcgca aatggtgttc aaggtgcttt tcaccgctga 3464161 aattcagcgc tgttgattca atagatgaag tgacgacgtt ccatccggca cggccattgg 3464221 acagatgatc caatgacgca aactgtctgg caatatggaa tggctcgctg tatgtagtgg 3464281 aggctgttgc tgtcagtccg atttttgatg tgacctgcgc caaagcagag agcagggtga 3464341 atggctcaaa ccttgttaat acatttggat gtgatttgct gtcaattgaa aggctgtccg 3464401 ctaaaaacag catatccagc ttgcctcgct ccgctgtttt cgcaagctct ttaaaataat 3464461 ccaaattcat gctcgcatct gacggcgcgt ccgggtgccg ccaagacgca acatgatggc 3464521 ctgtacctgc taaaaatacc cctaatttga tttgtttctt tttgcttgtc atggcgatac 3464581 tccttttatc atgtttttag gctgaataat ccgaaaaata aactcctata ttcctagtcg 3464641 tttaatatga ataaatcaaa atgtaccttt gtcttggacg tttgtcaatg agttaagatt 3464701 aattttttct attcaagcga aaagaccctt gcgtgaccat gagggaacgg cattgattca 3464761 ttcaactagt gcaacctcta tatcggcaag aaaactgagt ctaatgaagc aaagactcag 3464821 ttttcttcca ataatttcat ataagatttc gccatttcct ttgccttttc ttcgcttttg 3464881 caaaccgcct atccattcag acgccgtaac gattgtataa aaaaacagct gactccagat 3464941 attcaaaccg gaatcagctg attgatgtga attaattaag ctcatgaata ctctcttctg 3465001 ctttagcgga aaacacttta ggctccaaac agtcaaggtc ttcatgaaat aaatttactt 3465061 tttggatttg ccgattgtca tagtggtgga aatagtagtt tccagtttcg ttgcacatca 3465121 cggaagtata ttgcgtataa tgaatttcgt cttcttccgt tatcactgcg ccctttggta 3465181 tcgtcatatt tgccaaaatt tgaaaagcgg ctgttacacc tttcgtttca tcggccgccg 3465241 gctctagatg ttctttcaaa taaacagctc tgacaaaccg ggaaggcggt gtataatccc 3465301 ccggcagacc aacagttcct aagccttggc caaaagcaga aagggctaat ccgcccatct 3465361 ctttgctctc taattgcttc ggtctgattc ctgtatattg ctgcagattg gttacatgcc 3465421 atataaagtc ggggctgttc gtcatgacac caggttgatt atcatagact ttgaggccgt 3465481 ctgctcttgg ttctatcgtc aggtttcggc ccgtccggtc tgacaatatc cagtgaagcg 3465541 gtaaaactgt atccaataga tctaattttt tctctacaat cgttaaagat cgaatctttt 3465601 cttttacgtc ttccaaagac tgacagactg acagcaccca tgtcacaaac tcatgcggga 3465661 caatgtgaac ggtatcttcc cgtatcgttt tttcgtactc cgcatagccc ggaaaataaa 3465721 gcgccgcaca agataaaccg ctttcattaa tgccgtcggc aaataatata tttccaagtt 3465781 ttctccccat accgataaac gcgtactgtg tctgatgggc ccttccgtca gcttcactgt 3465841 tccagctgta acggcgcgga tagagaatca cctctgtccc cagctgaaat gcaaaatcca 3465901 ttgttcttgc taatacatgt ttacggtcag cagtttccaa tgtaagactt gtgcacattt 3465961 gatcagtccc cttttcaatt cagattaata tcatacatat tgtgaacgaa ttggttttat 3466021 cagcataacg aaagtcaaat cgattcgtca aagaattgac attacatcaa ataaaacgaa 3466081 aaaatccagc ctttagaagg ctggattttt tattatttag ccaaaacaag ctcgtgaatc 3466141 gcatgtgcaa cgccatgttc attattggag cgtgtttgaa agtttgctgc ttccaatact 3466201 tctgggatgg cgtttgccat ggcaaccccg cagcccgccc attcgatcat tgtcaggtcg 3466261 ttcccgttgt cgcctatgca catgacttcc gcctgttcaa ttccaagcag ctgagccagc 3466321 tggcgtacag catttccttt gctggcttcc gagtgcagaa tttcataaaa gaaaggcgcg 3466381 cttctgacca ttgtatattt ttctctcacg tcttttggaa tcgatgtaat gacgcggctt 3466441 aagttctccg gtttatcaat aaacatcact ttcgggatga ggatatcttt tggcacctcg 3466501 tcaatcttgc ggaaatgaag cggcacctgt gtcacatagg attcgtatac ggtaaattcg 3466561 ctaatatccc ggttaggcgt atacaaatta gatgagtcaa agaaatgcat cggcgtcttc 3466621 agctctaagc tcaggtcata taatgaagtc aaatcatcat aaccgagaga cagctctgag 3466681 accacttcat ttgtatgcgt attttgaaca agtgctccat tatacgcaat aacatagtcg 3466741 ccttcttcaa ttaaattcag ttcatctaaa tatctctgca cacccccgat aggccggccg 3466801 gtgcaaagca caattttgac accttccgct tttgccgcgt gaagggcgtc gcggacctcc 3466861 tctgttactt catgatgatc atttaaaagt gttccatcca tatcaattgc aattagtttg 3466921 tacatcctgc atctccttca tgtcgttttc aggctatagt cccatcatat cgttttttct 3466981 ttttgatatt caaccggaag agatggtttt ctccggattc tgtttagacg ccgcccttgt 3467041 cttcggatac gcaagcgcgg tttccgcttt ctttctgcct tgacgccgtt ttctgctttt 3467101 ttctgtttca tcagcagaaa gccggcagct agaaaaggaa tgccggttat attcaagatg 3467161 gcaagcttca cacccgccgc gatgaaaaag aacccccatg aagatgatgg attccgtctg 3467221 atcatgacgt aagccgccat ttccagaacg atcaggatgg catgaagcac tatgccataa 3467281 atcagcaata caagggcaaa aaacaaaaca taattcacga ttgcccctga gtacatcata 3467341 gcgcgcatca tttgtataaa cgataaggac tgcatggagc cgctgatgac attagggtta 3467401 tagatcgtat agtcactaaa taaatgtttg actttgagaa aagcccataa tataaatatc 3467461 cattgaatga tatgtaaaac aagccccgct gccaccagtc tttcagcttt ttgatttctc 3467521 atctttctcc tccctgccgg tctttgattc gattcttgtc atcgtttttc tctgtccatt 3467581 ttgctcccat atcaatgtcc cgttttctcc tcttttcagc gtgcttttga gcggataata 3467641 agggccgagg tactgaatct cgatagaccc gtcagtgctt tgggaaatca ccttgtatgc 3467701 cataaaaggc agctgtacct ctcctcttcc ttccatcact tccgtttcca caacctcgtc 3467761 ttcggtaaat gtgactgttg ctgatttcac accgtccgtt ggcccggggg cacgcccctc 3467821 atcccacgtt ccgtaataaa acggcgtctc ttctttttgc tgctggcagc ccgataccat 3467881 gatgcataca gcaattaaaa acaaaatgcc atatttgttt ctcaagggga tcaccattct 3467941 ttcctccttt tttgggcgaa tgccgtgcca ctgtgccaat gactacataa gttataagga 3468001 attcacccac aaggagactg atcacatgaa cccttatcaa tattacagcc ctcagctgcc 3468061 tcagcaggaa ccttactata gccactatga gtacaatcct tatccgcagc aggatgtata 3468121 cgatccatac caaatggaca gacagccggc attggaaaga agaatcgcag cacttgaacg 3468181 gcaaaatgaa cagcagtcaa gagaattaac ccgtctgaca aacgaagacc gccgtcaaaa 3468241 tcgggaaatt gcacggattg ccgaacaggt caatcagtta agccaggctg ttgaacgcca 3468301 tacacgccgc ctaaatcggc tcaatcagcg cctccgtaca gtagaaaacc ggctgaatat 3468361 cccatttact gcaggggaag gcggtttctg agcgaaacaa agaaaaaaag cggaatacga 3468421 ttctcccatc tcagggtttc gttttccgca tttcttatat gttaaaacgg aacatttaca 3468481 taaaaagggt ttgtacccag tatacaatct ttaccgtttt cattcaaaga tagaggggct 3468541 gaggaaaata attgtagttc ctctttgacg gaatttcttt tcattcaagt tgcatgataa 3468601 taccgactca cgtcaatcga tacatggagg gatcattcat gcataataca caacacggct 3468661 tgcagcagct gaaccaatgc cgccaaactg ctcagcagct cattcagcaa acacagcaaa 3468721 gcagccagca atatcgccaa atgcttcatc aggaacagca aaacatccaa atgctgcagc 3468781 agattctaaa ccacgaacaa caagctgcac ataccattca gcaagcactg cacgggcatg 3468841 acatggcgat tcaaaagtgc cagcaggttg tcaacatgtg caaccaaatg caacaggaac 3468901 ttactggaca atccagcgtc atgaatacga atgtgtctac acttccattc ggccaaaaca 3468961 cgacatttca gcagcaatcc taccagcagt aacatataaa aagctcaaca caatgcgagt 3469021 gttgagcttt ttttcttact gttctttgcg aatatgtata tcctgaatag actgtttcgg 3469081 tgcatgaaat ctgctctcgg cttcacttct tgcctcggca aaagcccgcg cctccacatg 3469141 atctttgtag acatccagct gaatcaaata cagcgggcgc actttaaatc catgaataat 3469201 ggttaccgcc cataacggga ccacaataaa aacaccgggc agatcgggca aaacaaaacc 3469261 aaacgcaaaa atgaaaaaat aaatgatgcc gtacatgatc cactttctat ttctaacctt 3469321 gatgccaata aataaaaagg caaaaaaact ggtaatggca aaaggcatga aaataaacag 3469381 catccaccag ctatgcagcc attcccaagc ggcacctctt tttgtaattc ccatattttt 3469441 ctcctcctat ttacctataa taatcgatta ggcacaccgc gtcacccata aacgggaaaa 3469501 actttctccc ttaaaaatag tgatagacgg agaacaggtt tcttgctata ttattaattg 3469561 ataatgataa tcattactaa tctattgaga tacatagtgg gagggttctt gatgaaaaag 3469621 aacatattgc tcgtgggcat gcttgtgctg cttctcatgt ttgtcagcgc ttgcagcggc 3469681 acggcttcta aagggagctc aagcgattct gcttccgaaa aaacagaaat gagaacatac 3469741 aaatcaccaa aagggaacgt caacattcct gcacatccga aacgcatcgt cactgatttt 3469801 tatgccggtg aattgctgtc tgtcggggcc aatgtggtcg gctcaggctc atggtcattt 3469861 gataatccgt ttttaaaatc aaagctgaaa aatgtgaagg atgttggtga tccaataagc 3469921 gttgaaaaag tgatggagct tcagcctgac ttaattgttg tcatgaatga agagaatgtt 3469981 gataaattaa agaaaatcgc tccgactgtt gtcatacctt ataacacagc gaaaaacgta 3470041 gaagacacag tcagcatgtt cggagatatc gccggagcga aagaccaagc aaaatccttt 3470101 atggctgact ttaacaaaaa agcggaagca gctaagaaga aaattgccgg cgtcatcgac 3470161 aaagatgcaa ccttcggcat ttatgaaaac acagacaagg gcgaattctg ggtgttcaat 3470221 gacaatggcg gacgcggcgg ccaagctgta tacaatgcac ttgggttaaa agcgcctgaa 3470281 aaaattgagc aagatgtcat caaaaaagga gagatgaaac agctctctca agaggttatt 3470341 cctgagtatg ccgcagatta tatgttcatt acggattaca acccgaaagg cgaaagcaaa 3470401 acactcgaca agctggagaa ttcctccatt tggaaaaatc ttgacgctgt taaacataat 3470461 cgcgtgttta tcaatgactt tgactcgttc tacccgtacg acccgatttc tgtcagcaaa 3470521 caggtggata tcatcaccga catgctgatc aaacgggccg aagaaaataa aaaataaaaa 3470581 aacggcacag tcatgacgct gtgccgtttt ttatgattca ctttaatttt gactgtacgg 3470641 agtccggcat atcttcaaac ttgacttctt cccaagtctc gacatacttt cctttcgcct 3470701 tcaccttcaa atacgcgttc ttccgaagct ctttgccggc gaaaaaggtc acttcttctt 3470761 ttttcccgga tgcattatat ccgtctaatg tatattcagt accgcccgga ctaagatgtc 3470821 tgccatctcg atcaatctga acatagacat cttgctggtg aataaacgga ttaaatctgt 3470881 ctgtaacatc gttatgaaaa aagagaagcc cgcatattac ggcagcagcc gccaagacgg 3470941 ccaggattgc cattgctttt ttcatctttg cactcccctt acttgttcat ttttttcaaa 3471001 tagcttgacc gcaccgcgag gaagaataga agctgaaaaa tgaaaaaccc tccgatggtg 3471061 agactgagcg gccccgctac atcggaatat ccttccacag ccaatgttct caaggcaaac 3471121 agtgtatgca tgacggcaat gacaaatgga aagaagaaaa gaatcgccaa ttgtattgtc 3471181 acgctttgcg ccatttctcg ctcactcagg ccgattttgg ccagtgaacg gtagcgctcc 3471241 cggtcttcat ctaaatcagt gaacagcctg aaatataaga aacttgctgc cgcgacaaag 3471301 aatacaattg cgataaacag gccgataaat agactcaggc tcggcagctg caccgtatca 3471361 tagtaagtcc ccgcttttga agcaaaatca gaatgcacgt cgatataatt gccgtaaatc 3471421 tcattttgca aggattggct gatctcaaga ctgtctttcc aatgatcata gctgtagccg 3471481 tataatgacg ctttatcacc gagtgatttc agctgatcaa aggtttgatc attcaccgcg 3471541 atgatagcat tcaatgagat cagcggtttt ttgacttctt ttaccgacag tttttgatca 3471601 gacagctccc ctttttggtt cagcagcttc agctgatccg gcgcttcgtt tttgaaattg 3471661 cggtcatacg ttcccgggaa atagacagcc tcgtcttctt tcaggccgtt cactttgaca 3471721 tggaagtatt ttgccgcatc cgattcactg atcatgtaaa cagggggaac agtttctcct 3471781 tcctgatagc gaacatagga aacatctatt ttgtctttcg tatacgtaaa accgtgtgtt 3471841 ttcagttcat ggtcaatatc tttcaaatga gtctgttctt ttggattgtt gctgtaagat 3471901 aaatactcca tttcataagc ggactcttcc gctccgacgg tcgatttgta cattgcgagc 3471961 acgcctgtcg cagtaaacgc aaccgcggaa ataatgctga caataaagaa caggcgggcg 3472021 ttgtctttta gacgatagac aaggtcagaa acccaaatga tgtttttccc gcgcagataa 3472081 aaggttttcc acttcttcag cgcgcgcaga atccatatgc tgctttggct gaaaaagaaa 3472141 tatgttccga taacggtgag cagtaaaatg ataaacggtt cggccccgtg gacattgcct 3472201 ttaagaacca tgccgtaccc gccgcacaga caggcgatgc cgaataagga cagaagcacg 3472261 gacggcttag gctccggttt aaccttgcca gtgcccttta ttaatttgat aaccgtattt 3472321 gatctgacaa aaaggatcgt aaactgcgat aaaaagaaaa ataagagcag aaatccgcag 3472381 gccgtaatac cgagcgcttt ccaaggcata tacaaaggca gcgcgtccat ttctaaaata 3472441 taagcgccga ccgtaaagaa cgtctttgaa aaaatgaatc ctccgataat accggctgca 3472501 attgacatga cgccgatgat catattttcc gcagtaatga gctttctcag ctgccccggc 3472561 gtgatgccct gcatgagcag aatgccgaat tctttatttc tcgatttcaa aaatgcatta 3472621 accgaataca gaacaaataa gaaagaaaaa acaaagatca tccattccgc ggcggttaag 3472681 ccttttttgg cgatgttatt caggtagcct tcctttaatg ccggatgaaa caggaacatc 3472741 gcaaaggtaa agaaaatcaa aacggaaaag gcgctgctta aaaagaatgc aagataggcc 3472801 cttttgtttc tcgtgacgtt tttataagcg aactgaagaa aggtcatttg cgtttccccc 3472861 cagcatagac agcacatcga gaatttgttc ataaaatact tggcggtttt ccccgcggta 3472921 aatctcatta aacagttcgc cgtcttttat aaagatgacg cggcggcagt agcttgccga 3472981 aaccggatcg tgggtcacca tcaaagccgt gacatgatca tcccgattca ggctctgcaa 3473041 cgtttccatg acgtcttttg tcgctttgga atcaaggttt ccagttggtt catcggccag 3473101 aatgagtgac ggcttatgaa tgaccgctct tgcgatggcg gcccgctggc gctggcctcc 3473161 ggatacttca aacgtccgct tgttaagcag gttttcgata ccgagctttg ccgcgatgcc 3473221 gtgcagtttt tcttccatta cagacggcgc ttctttttca agcgttaacg gcagcatgat 3473281 attttcaccg atcgtcagcg tatccagaag gttgaaatcc tgaaacacaa atccgagctg 3473341 cttgcggcgg aaatgagcga gctttgtccg cttcaggcga tgcgggtttt ctccgttaat 3473401 caggatatcg cctgaatctg gacggtcaat cgttgaaatg atattcaaaa gcgttgtttt 3473461 tccggacccg gacggcccca tcaccgccgt gaactcgcct tcttctattg aaaatgaaat 3473521 ttgctttaag gcctgatagg acacttgtcc tttataggtt ttatttatat gtttgacttc 3473581 aagcatattc gccatgaaaa tcctccttat ggttttattc ttgttgatct gggctgcttt 3473641 catgtagtgc cgggacgttc aacataaaaa tccccttgac ataaatccat gttatcaagg 3473701 ggaaacaaag cgggctatgt tgttttctta acgcagcctt acatttttgt aagaaatgaa 3473761 aatcgaactg atgtcccttc accgggagac gagctgatgt ccaccgtatg attgagctta 3473821 tctgtaattt ctttgacgag atggaggccg attcccgtag attcttggaa acgccgcccg 3473881 ttttcacccg tgtaataagg gtcaaacacc cgcttgatgt cttgtgaggg aatcccgaca 3473941 ccgtaatctt tgacttcaag caccgtcctg tcttcatcgc agaagacatt cagctcaagt 3474001 ctgtcactct tgcccgctga atacttgacc gcatttgtga ccacttggcc aatcgcaaat 3474061 ttgagccatt tggcatcggt gtaaatctga tgatcatcgc aaacgttcat tttcggataa 3474121 acgcgatatt gaataaaaaa tcgtttatag ctttgaataa ctgattggag aagctcggac 3474181 agggaaaccg cttcgatttt aaaatcccgt tcaaacaggt cgagccttga agaataaaga 3474241 agcgtctcca gcccgaattc aatctgccgg acttcttttt tgatttgttc aaaaacgggc 3474301 tcatcctctt cttgaatgat taaattaatg accgacagcg gcgtctttac ttggtgcacc 3474361 cattgattca tatacgtcac ccgcgcgtca agcttggctt cggtctcatg gagcttctgg 3474421 tgctgcagcc ggatcagctc catctgcttt tcatacagct ctgaacagaa cactgaagaa 3474481 ccgagatacg ggatatccgt cccttcctgc cccgagctga gccaatgata cacgccgcgg 3474541 tctttgtacc agcgataggc aagatagccc gccaaaataa gaagctgcac gcccaatatg 3474601 taaaacaagt gagaaaaaga atgaagaccc gcaaaccagt aataaaagaa gacaaacagc 3474661 ccttgaagga gaaaaagcag aatcagcact gcatgagacc ggagaaacag cttcatgact 3474721 gcgccctcag ctggtagcct tcgccccgca ccgcttcaat agaaacaggc gcattcagct 3474781 cccgcagttt ttttctgagc cgcgtgatat acacgttaag tgtattatca tcgatgaata 3474841 tgtcggtgtc ccacgtcttt tccatgagac ggtcccgact cgtcaccttt tctccccgct 3474901 caagcagcac ttccaaaagc ttgctttctt ttttagaaag ctcacttttt tcatcctgaa 3474961 aacgcagttc aaaccgttcc acaaagagct gaacgccggc atattcaacc actttctctc 3475021 cctgctttgc ggcgtactcc ccgtacgccc tccggatctg gcttttgatt ttcgcaagca 3475081 caatatcata agaaaacggt ttttcgatat aatcgtctcc cccattttca atcgccatca 3475141 cctgatccat ttccccgctt ctggcagaaa taaagatgat cgggcttgtg gagtgctggc 3475201 ggatctgccg gcaccaataa tatccgtcat atgccggcaa attgatatca agcagcacca 3475261 catcgggctt ttcccgcaaa aagacatcaa gaacagctgt aaaatccgcg gcgaccactg 3475321 tttgatatcc gtatttttca aggtaattct gcaatagtcc gcgaatgtct tcactgtctt 3475381 ccacaatcat gattttattc aaactgaacc actcccgttt cttacactgc tgccatcatc 3475441 ataatcgttt tgggcgtatg gacgcaacac cgcacaaaaa aaccgccatc tcggcggttt 3475501 ctggtctctt tagccgacct gctgcttagc tgctttaccg gctgatccga actctctcat 3475561 tttgcttcgc actgtctctt ccacggcttc aatgccgggt gtcaaatagc cgcgcggttc 3475621 gtacagatcg ctgttttcct gaaacatgcg gcgtgtttcg tctgtccacg ctaccataca 3475681 ttccgtattg atattgatct tcgcgtggcc gagcgtgatg gcttttttga tctgatcctg 3475741 cggaatcccg gatgccccgt gaagaacgag gggaatatca gtcatgcggg agatagcctc 3475801 catttcctta aatccgagat tcggctcacc ctgatatttg ccgtgtacag agccgagggc 3475861 ggcggccagc gcgtcgatat tggtttcttt aacgatccgc tcacattccg tgatatccgc 3475921 atagcggacc ccgccgacca gtccgtcttc cattccgccg accgtgccga cttcggcttc 3475981 tactgacacg ccgtgttttg cggcataatc ggtgacttct tttgtcatcg cgatattctc 3476041 gtcaatcggc tgatgggagc cgtcaatcat cactgagctg aatccggcat caatggcctg 3476101 tctgcagcgt tccgcactgc tgccgtgatc gagatgaagc acgaccggaa cggtaatcgc 3476161 catgtcctct attaacgcgc cgaccatggc ggcaatcgtt ttaaatccgc ctaaatagtc 3476221 gaccaggcga tcggaagccg cggcgatgac cggtgattgc tccttttgcg ccgcctgcaa 3476281 aatcgccttc gtccattgca ggccgttgat attaaactgg ccaattgcat attgctcccg 3476341 ctttgcatct tcaagaagct ctttcatcga tacaaaagcc atattcaccc ctcctttatc 3476401 cattacatgc tgaagtattt tgatacgaca tccactgttg tttttttcgc tgtttgaatg 3476461 gcttcctcag cagtcagctt atagtattca ggccggaaga gctcaaccga aacaacatca 3476521 gagaagccga tttccttcag tgctgataag tgggcatcta agtcaattgc cccttgtccc 3476581 ggccatacac gatcctcatc tgttaaaaag ccgattggga aatcttctgt atcatcaata 3476641 tgatagatga agattttctt tccgtccgcc tgctttaagc tctcaatatt tgaacccatt 3476701 gcatggaagt gaaaactgtc aaggacaagc ccgacattgt cacggttaac tgtgtttaca 3476761 atctcatacg cctgttcaaa cgtattgacc gtacattgcg gatggccgac aaactcaagc 3476821 gcgattttta cgccgtacgg ctccgcgata tctgacagct cagtcagcac gtctacactg 3476881 ctctttttga tctcttcttt tacaatcttc tgctctgtca caagcggaac ggccaccaca 3476941 tatttcacac cgagggtttt gcatgtttcc atcatgcctt taaattcagt gatgatctcg 3477001 ttgtgaccct tttcatcacg gttgttgaag aaaacgagtg cgtttaaggc aagcggtttg 3477061 atgtggtggg tttgaaaata ttccgcaagg tcatccaatg aatgatcttt taagtactcc 3477121 ggcagcttat ccatagtacg gatttcaata taatcatagc catgcttttc gcatagttct 3477181 aaatccagtt taaggtttga gttttccaat gttgtcgctt cattaaaaca aagtttcatg 3477241 ccagactccc ccatctgcgt tttagatatg aagggagttc ggcaggaagg ctgtcgccat 3477301 atcccgccga actccatgct cagcttatgc cagacctaat tcttctttca ttttcttaag 3477361 cataaatcgg cttgattcat ccgctctttc atcgacccaa gcaaatacgg cattcgtcgc 3477421 aattccgtcg aacttcatct ctctcagttt tctgaaaatc gtatcaaaat caacctcgcc 3477481 ttggccaatg tccaaatgct ggtgaaccgt tactttcgcg tcaggcggat tgacgatgta 3477541 gcgaaggcca tgagccgctt tatgattata ggtatctgca aataaaacat gtgtgaggcg 3477601 gtcgccggct tcgtcaaaca tggtctcgat gtcgcctttg ccgtcatcat agaagaacgt 3477661 atgcgcagtc gagtagacaa gattgatcca atccttgtca agcgcgcgga tcatatccat 3477721 cgcacctttg tgcgtttcga taaaatcata tggatgggct tgaagattga gtttaatgcc 3477781 ttctttttca aagactggca gaagctcatc catggatttg ataaattttt cttcacttgt 3477841 taaaggatca tattttgaac cgctgaattc gctgttcatc aaatccactt caagttcaac 3477901 cgcaatttcg attgcccgtt tccagttgcg cactgctgcc tggcggcggt cttcatcggg 3477961 tcccgcccag tggtaaagag gaagaagcga tgaaagctta acacctgtat ctcttaaaag 3478021 gcgctttaat tgtttgatct ttgctgaatc gactttcgga tatttataaa acgggcaaaa 3478081 atcctcgcgc ggcgataatt cgatatattc atagccgagc tctgccgttt tatagaccat 3478141 ttcctctaaa gttaaatcat cacgatacat ggatggatcc aatgctaact tcatattttc 3478201 actcctctgt tttttagttt tgaactgttg taaaagattg atagaattcc ggtttttcct 3478261 tcaattcaac cttttctttt tgtccagatt cctgggcttt tacacacgcg tcagtcgtga 3478321 cagcagcaat atagccgtcc catgccgtcg gtccgctgac ctcgcctttc ttttgaatcg 3478381 aatcaataaa gtcttggatt tccacatcat acgcagcgac aaagcgtctc tgccaatcca 3478441 tcaaaatatc agtgctgaat ctgccttctt ttctcaagct gatgcttgat ggctcgggaa 3478501 gcttgatgat gccgtcttct ccgacgattt cacattgaat gtcatagccg tatttacagt 3478561 tcacatagat ttcagcattg atgacgatac cgccttttgt ttcaatcacg acgatttgcg 3478621 gatcttttaa atgtggaagc gcgttttttg attttttcgg atagatgact tgaacggact 3478681 cgtagtcatc attgacgagc cagtggagca cgtcaatttc atgaacaagc gtgtcgacta 3478741 cagccatatc cgttgtatag ttatctccta cagtcgggtt gcggtgcgcg cagtgaatca 3478801 taagaggctc gccgatgaca tgattatcga gcgcttcttt cagctgtacg taaccgctgt 3478861 cataacggcg catgaagccg acttgaacaa ggcgtttgcc cactttgatt tcttcttcga 3478921 caatgcgcat gcatccttca gccgttgtcg cgagcggttt ttcacagaac acatatttct 3478981 gggctttaat cgctttcagc acgcttgact catgcgcagg cccccagctt gtcactaaaa 3479041 cagcgtctac attttcgtct gcaagcaagc tgtcatcatt cggataaacc gtcgcgttta 3479101 attggtattg ctcaacgacc ttttgtgcag cttcttgatt aacatccgtt acagctacaa 3479161 tttccgcgcc tgacagcttg ttcgtgatac ggttaatatg ttcttttccg attgctccag 3479221 ttccaattac gccaatacgt aaactcattg acagccactc cttctgttgg ttacatgatt 3479281 ttgctttctg ttcctttctt tacttggctc tgaggagacc cgtagagttc ctcttgaatt 3479341 tgttcaagcg acttgccaga cgtattcggc gcaaagagca gcccgatgat catactggcc 3479401 gtcacacatc cgagaagaat tgcagccatc gttccaatgc cgaaattggt gataatcatt 3479461 gggacaaaca gactccaaat ccctattgaa atacggacaa ggaaaaacat cagtccttgt 3479521 gcggaagcac gatattgcgt aggaaagatt tcgctggccc ataactgata gttcgcttgc 3479581 tgcccggctc cgttattgat gccgatcacg acaataaaca ggagcagaat cggcaggcct 3479641 tcaactggca gcagaaacag tgtccacccg atcaccgcca tgaaagcggc gattccaaat 3479701 acggtttttc tatatttgtc ggcaaagggc atgaagatca aggcgacccc caatcctgtg 3479761 aagataaaca gccccatttg caaaaggttg gccatgttgg cagatacacc gccgacctgc 3479821 tgataaatgt atggcataaa gaagcccatg accccggcgg ctaggttcca aaccaagtac 3479881 acacccatca aaaacaggat gctttttaga tacataggct tgagcaaatc aaaatacgat 3479941 gtcttattca atacagccgg cttctctgcc tgagcttcct ccggctgatt ttttgtctgc 3480001 caggcgtctg attccggaag cctgattctc aggatgtacg taatcagcgc aatcacaagc 3480061 agatgggcaa atacgatttt attccccaag agtcccaagt caccggccag tacggagagg 3480121 agcagtacaa cgacagcgcc cgcggcccaa gcgacttgtg ctacgccgca atgcctggcc 3480181 cgattcttct ttggcgcatt ttccgcaata atggtccatg acgcggttat gtcagcccct 3480241 actgataaac cgataatgat gtaaccgctt aacaacatgg ggaaattaac cccgaacaaa 3480301 accaaacaaa tccctagtgc ataaaccagc atactattgg tataaacagc cttccgtccg 3480361 actttatcag ccagaaaccc gccaagcagc gcgccgacag cggcagaaat cgcatttgcg 3480421 ctcaacgcgc cgagcagccc gatttgcgta tcggatagct taaggtaact gacccataat 3480481 gataaaccgg cggagcctgc cacaattgaa ccggcatcaa tatagttggc caatgctgcc 3480541 gcgattgtcc gtttattgaa ggctgaatct ccattggtat tgcccatatg ttcattcccc 3480601 attaagccag atccaacaac tgctgatcaa tatagtttct cgcaatcaat gcatactcca 3480661 gcgggtttgc aacatcgggg tcttgttcag cttcaatgac aatccatccg gaataactgt 3480721 gcttcaacag cagctgatat acttctctaa agtcaatgca gccgtcaccg ggaaccgtaa 3480781 acatgccttt taaaaatgat tgccggaacg attgtccttc gagcctgcat tgttccatga 3480841 cattcaggcg ggcatcctta aagtgcacat gcttaatgcg gccgatatgc ttctcaagca 3480901 tccccatgta atcgccgtca gaaatatacg catggcctgt atcatagagg aggtgtacat 3480961 gcgcagggtc tgttcctgcc atcaggcggt ccacttcttc cgctgtttgg acaccagtgc 3481021 cgagatgatg atgatagaca agcttcaagc catgctgagc ggcaatttcg ccaaggtgat 3481081 tcagcccttc gcaaagccgc tcccattcat catccgtaaa gtgcggcttc tctgtgaaca 3481141 catttttctc caagctttgc acgctgtacg tttgttcaga gacaactgcg acatccgcgt 3481201 ttacttgctg caaatactca caatgcaggg taaatgtctt tgccgcttca ccaagtccgt 3481261 cacgcaaaat aaaactgctg aaccattttc ctgcaatgcg taagttccga agcttcagct 3481321 ctttgttcag gatggcaggt tcggggaaaa agcccccgac ctccgtgcct tgaaaacgtg 3481381 cgacaacgat atcacttaac aaatgctgaa gtgtatttcc cgctccaatt tcaggcatgt 3481441 catcattccg ccacccaatg ggagcgattc cccacaggat ttcatttttg cccatctatg 3481501 gtgcctcccc tctaatactg cttcgcagat tccagctttt tctcttttgc ttcgtatgct 3481561 ttctgaacgc tttcttgttc agatacctct gccaccccga catgccacca gctgtcatag 3481621 ccgtccgtca ttgttttagg cagcaccttc atttcaatta atgttgatac atcctgtttc 3481681 ttcgcatcct ctaacgcagc ttttaattct tctactgtgt ttgcacggta ggttttcgcg 3481741 ccgtatccct cagcgacttt cgcgtaatcg acattcagga tttggttgtc atctgtgcgg 3481801 aactcgcaat agtagctgcc gctgccgtga tccatttgca ggttgttgat gcatccgaat 3481861 cctgagttgt caaagagcag cacattgatt ttcttgttgt actgaatcgc cgtgatcagt 3481921 tcagaatgaa gcatcaggaa gctgccgtct ccgacgattg aatacacttc tctgtcaggg 3481981 tgggccagtt taagaccgag tgtcccggac acttcatagc ccatgcaaga atatccatac 3482041 tccaggtgat acgtattcgg aacattagaa tgccacagac gctgcaaatc tcctgggagt 3482101 gagcctgctg aacagatgat gacgctgtct tcaggaatcg tctcgttgat tgtcagcaat 3482161 gccgttgttt gcggaagctc cgtattcaac gcgtcagcat attcattcag gacctcttga 3482221 gaaaagtgat ttttgatttc cggatcaaat gcttcccgct taaacgtcac tttgctgaga 3482281 cgctcgcgtt cagctagcca ttcgtccttc agctcccgga tcgttgtgcc gaactcgctc 3482341 tcatagcctt caagcaagcc gtgcagtttg ccaagcgtca ctttcgcatc cgccaccact 3482401 tggaatgcat caagtttata cgcctgcatt cggctgacgt taatgttcaa aaacttcgct 3482461 ttatcaaaat caaaagcggt cttagaggat gtcgcaaaat ctgtatacct tgtgccgatg 3482521 ccgataatca aatcagcttg gcgggccgct ttgtttgccg caagtgtacc tgtgatgccc 3482581 attccgccaa ggttgttcgc aaaatctgcc tcaacggtag actttcctgc ctgcgtttca 3482641 actaacggaa tgttataggc ttcagaaatg gcaaccaatt catcgcgcgc accggaatat 3482701 tttgcgcctc cgccgacgag aatcacaggt tttttgctgg atttaatcag ctccgccgca 3482761 ccttgaagct cgcgctcgct cggctgcatg cgatcaatat agtgaacccg tttgacgaag 3482821 aaactttcat caaaatcgta tgcttcccct tcaacatcct gagaaataca aatcgttgcc 3482881 ggacctgctt ttgccggatc agtcatgact tcaaacgcgc gcagcaaact gctcatcagc 3482941 tgctcagggc gcgtaatgcg gtcccagtat ctcgatacag gcttcaatgc atcgtttgtc 3483001 gtaatcgccg cactgtattc ttgctccatt tgctgcagta cagggtctgg ctgtcttgtc 3483061 gcaaatgtgt ctgccggaat caagagaact gggatattat ttgccaatgc agtgccggct 3483121 gccgccacca agttagccgc tccaggtccg acggatgtag acaccgcata tatttttctt 3483181 ctcagcattt gcttgctgta cgccatggcc gcatgcgcca ttccttgttc atttttccct 3483241 tgatagactt tcaaatggcc tgcatcctgc tcaagcgcct gcccgatccc taatacgttt 3483301 ccatgaccga aaatcgtgaa gatcccttcg acaaaaggct cttcctttcc atctacatgg 3483361 atgtactgct ggtttaagaa tttaatcagc gcctgcgcag ttgttaagcg aattttctta 3483421 cccacaaacg atcccacctt tactcgatct ttttcaatta tgactgtgct tcaataagct 3483481 gttcgatttc ttccgcagtc ggcatcgctt ctgacgaact gtgcttgctc accacaatgg 3483541 aggctgaagc actgccgtat ttcaatgccg tttcaatgtc ttttccgctg acaaggccat 3483601 agataaaggc tgacgcatag gagtcaccgg ccccaaaggt tttcagcact tttgtcttgt 3483661 acgcttgagc gcggaatacc tcgccggatt tgctgtatgc gtaagagcct tcgacgccgt 3483721 gtttgatgac aacgaggtcg gctgaatggc caaataaatg attgacggat tcttcattgc 3483781 ttccgcctgt gcggttttcc atcacatcaa attcatcgcg tgtgccgatg acgatatcag 3483841 actgctcggc aaccaaagaa taataaacgg ctgtttcatc tgatgactgc cacgtatatg 3483901 gccggtaatc cagttcgaat accaccttaa cctgatgctt tttcgcgtat tgaacagctt 3483961 ttaacaccgc ttcccgtgac gggcttttgg cgagcgctgt cccggagaca agcagcattt 3484021 tcgcatttgc gatatagtcc tcacttacct ctgaaggctc aagataaaga tccgccacat 3484081 catcgcgata cattaagatg ctgcattctt cagggctgag gatttctgta aatgcaaggc 3484141 ctgctttgtg tccatcttga tcaacaatca tctgtgtagt atccacgccg gtctttctca 3484201 tataggactc tatgaatctt ccatgctggt catccggaat tttgccgatg aagcccgctt 3484261 ttaagccaag cttcgcgctg ccgatcgcga tattcgcagg tgaaccgccg acatatttcg 3484321 aaaatgtcat cgtttcttcc attgggcggt tgtattcgac tgcgttcaga tcaatacatg 3484381 cccggccgat ggcaacaata tcaaaagcct tctcttcatt gaatgtatac ttcatcgtaa 3484441 acagccactc ctcacttgtt agcgttctaa aatccattca tgcgccgggt cgttataaaa 3484501 cttccatttt cgcgtcggcc ctgccatgac atttaaatag taggatgtgt atccgtccgg 3484561 aacgcctacc gggtggtatc ccgcaggaac gatgacaacg ttttcatttc ccacagtcat 3484621 tgtctcgtca atagaacggt catctgtgta tacgcgctga aacacaaagc cctgtcccgg 3484681 gtctaactca tggtagtacg tttcttctaa gaaagattct tccggcaagt tgtcttggtc 3484741 atgtttgtga ggcgggtagc tggaccagtt gccgctgtct gtatagactt caactactaa 3484801 tagactgtta gctgaagggt ctgaatccgg aagaatgtta tgaacagtac gtttgtttga 3484861 aaattgcccg cgatgctcaa ttccgttgtc ttccgctttg atcagctttg tcggaagctg 3484921 cttttccgat ggagaatagc aaagcgccac tcttgcgtcg ctgaccgctg tgatctcaaa 3484981 tgcacggtca tttgaaatat agacgctgtc tgtcggtttt cgttcaaata cgctttcgcg 3485041 cgtgccgata ttctcaaaag tcgactcatg atctgtcact gtaattttcc ccgttaccgc 3485101 cacaatacag atttcttgtt ttttcaattc ttctgtatag cttgaacctg atgcaagatc 3485161 taacacttta aactctacat aagtgagatc agagttggat gtcgttactt cgtgcacgag 3485221 tttgacccca ttagacactt catgcgactg cggcttacgc aacaaataac tcatagagaa 3485281 gccctcctct ttctattggc agaatgagtc cgaacagcgc acatggacgc cgttcggctg 3485341 ttcgtcgttt agttgaaatc aggtgccgga tatcttgccg tcaccacttt tttacgtgta 3485401 tagaagtcga cgctgtcttt tccgttcgca tgcagcgttc caaagaatga agatttccag 3485461 cctgagaatg ggaagaacgc cattggagcc ggcacaccaa ggttgatgcc tagcattccc 3485521 gcatcaatgt tttcacggaa gtagcggatt gcgtttgagt tggatgtgaa caagcaggcg 3485581 ccgttcgcaa actcagactt attggcgatt tcaatcgctt ctttcaggtt tttcacacgg 3485641 atgacagata agaccggagc gaaaatttca tctttccaga tcgtcatttc tgttgtgaca 3485701 ttgtcaaaga tcgtcgggcc gacaaagtag ccgtcgtcag acacattttc acgtccgtca 3485761 catacgagtc tggcaccttc ttcaagacct ttttcgatat agctgagcgt gcgcttcttg 3485821 ttgtcttcgc gaatcaccgg tcctaagaac acgccgtcat caaggccgtt accgatttta 3485881 atgtccgcca ctttttcctg cagcttcgcc ataaattcat cggcgattcc ttcttcaact 3485941 gtcacaaccg cacaagccat gcagcgttca ccggcagaac cgaaggcagc tccaacgatg 3486001 tttgtaaccg tgtcttcaag attcgcatcg ttcaagacaa tcgtatggtt tttcgcgcca 3486061 gtcagagatt gaacgcgttt taagttttcg cttccttttt tgtagacgta ttcgcctact 3486121 ggcttggagc ctacaaatga aatcgcttta atttcgggat gctcgaggat gccgttcaca 3486181 acgtcatgcg caccgtatac gacgttgaac acccctttcg gaaggcccgc tttttcaaaa 3486241 agctcaacca atttctctgt taacagcgga gtccgctcag atggctttaa aataaatgtg 3486301 ttgccgagcg cgatcgccat cgggaacatc cagcaaggaa ccatcatcgg gaagttgaat 3486361 ggcgcgattc cgccgacaac tccgattggg taacggtagt tcgccgcttc aacgtccgtt 3486421 gcgatggaag caagtgagtc acccatcatc agggaaggtg ctccagcggc gaactctacg 3486481 ttttcaatcc cgcgtcccac ttcacctaaa gcttctttcg tgttttttcc gttttcaatg 3486541 gtaattagat gagcaagttc ttctttatgc tgagacagca gctgctggaa gttaaataga 3486601 attctggcgc ggcgaggaac cgccaccttt gaccatgttt taaatgcttc agccgctgtt 3486661 tgcgctgcgt aatcaatatc ctcttttgta gaaatcggca cttggcatag cacttctttc 3486721 gtcgccggat tgacgacatc ttcatattga tctgttttgc tttcaaccca ttcaccgttg 3486781 atgtagtttt ttaattttct gatttctgcc attcttattg cctccttcat tagtaaacac 3486841 atacacttgt atggatggtt ccggatagat tcatatcaat atccactttt cagcaagcca 3486901 agaattaaac gctttcaaaa acaccaaaaa aataaatggc ggatgcatat ttacatacaa 3486961 gcaaccattt catgcacaac aggttacttt ttggtcattt cttggttata ttctaatcgc 3487021 ataataccca taagtcaatc ataaacacta cattttttca ttatttttat tatattaatc 3487081 ttttaatcaa gtaagagaag taagagaagg ccgtccaatc ttgcaaaaga tatacaccga 3487141 tgttatcatt tttaagcaac tattgattaa cttttggttt ttattatata tttatgttac 3487201 gtaaagattc aagaaggagt tttttatatg aaactgatgc ggattcagga aatggaggag 3487261 tacattttat cgcatggcac tgtttcctta gatgagctgt gccaggtgtt caatgtctcc 3487321 aaaaacacag tcagacgtga tatcaacaag ctaacagaaa agggtgcgat tgaaaaagta 3487381 tacggcggcg taacatctat tgaaaaaacc gcattagttc cttttgaaaa tcgcaccatt 3487441 cagcaccagg atgaaaaaac aaaaatcgcc cattatgctt cccgatttat tgaagatcac 3487501 gatttggtct tcattgattc aggaacgacg acaaagtcta ttcttgatac gcttgatcca 3487561 gccaaaaatg tcaccatctt aaccaacagt ttagacatta tcaatgcggc gtcagctttg 3487621 aagaatatca acttaatcat tatcggaaac aactataaga gaaaaacccg ctcctttgtc 3487681 ggcatggacg acccggctat gcttgataag tacaatatca acaaagcctt tatgtccgct 3487741 accggaacga cgctgactca cggattgacc aattcggatc tgctggagta tgaaattaaa 3487801 aagaggattt cagaaaaagc aaaagaagtg tatctattgg ctgaccattc taaattcgga 3487861 aaatcaacgc ttctgacgta tgcaccgttt gacaggctgc attgcattgt gacctctcag 3487921 ccattagacg acgagtacac gcagtactgc aatgagcatc aaatcggcat tcatctggcc 3487981 taacgtttac aatagtgttg agagtctatc atccatttta ttctaggagg cagatcatga 3488041 aaaaagcgaa gctcggaaaa tcagacttgc aggtattccc tatcggatta ggaacaaatg 3488101 ctgtcggagg acataacctc tacccgaacc taaatgaaga aaccggaaaa gaattggtgc 3488161 gcgaggcgat ccgtaatggc gtgacaatgt tagacaccgc ttacatttac gggatcggcc 3488221 gttccgaaga attaattggt gaagtgctgc gtgaattcaa ccgtgaagat gttgtcatcg 3488281 cgacaaaagc cgctcacaga aaacaaggca atgactttgt ctttgataat tcaccagatt 3488341 ttcttaaaaa atcagttgat gaaagcctga agcgcttgaa taccgattat attgatttgt 3488401 tctacattca cttccctgac gaacatacgc ctaaggatga agccgttaac gcgctgaatg 3488461 agatgaagaa agccggaaaa atccgttcca tcggtgtatc caacttctct ttagagcaat 3488521 tgaaagaagc aaacaaagac ggtttggtag atgtattgca aggcgaatac aacctgttaa 3488581 accgtgaagc ggaaaaaaca ttcttcccgt atacgaagga gcataatatt tcatttatcc 3488641 cttacttccc tctcgtatca ggtttattgg caggaaagta tacagaagat acaacgttcc 3488701 cagaaggcga cctgcgaaac gaacaggaac acttcaaggg tgagcgtttc aaagaaaata 3488761 tcagaaaggt caacaagctt gcgccgattg ccgaaaaaca caacgtggat atccctcaca 3488821 tcgtattggc ctggtattta gcaagaccgg aaattgatat tttaatccca ggagcaaaac 3488881 gtgccgatca gctgattgat aacatcaaaa cagctgacgt gacgctttct caagaggata 3488941 tttcatttat tgataagctg ttcgcataag aagaaaacag ccttctccaa tggagaaggc 3489001 tgtttttttg tgcgataaat tcctaaataa ctgattttga agcaaaacct tacaaaatga 3489061 gccataaatc cgataaaata aaggtagttt atctcagaaa gaaagtgatt gagaaagcaa 3489121 aagtatgaaa cgttcatatc atctagctca tatgaaataa agctgaccca gcttctttta 3489181 tttgctggtc agaatagcgg accgtttcga tggtctatgg aggaaacaga atgaaactta 3489241 aatatgtaaa agccttagtt gcagtaaccg ttgctttagg tgtactgctg ccatcaacga 3489301 tttctcatgc aaagagcttt agcggccgct catcatctag ttacagcagc cgaagttcaa 3489361 gctcatcata cagcggaagc tataaatcaa gcccgaaatc aagctacagc tcaggatcaa 3489421 gctcttctag caaaaaatcc aagacgtctg acgattcatc atcatcgatt tcgcttaaaa 3489481 agaagccttc ggaaaaggca agttcatcaa gctctaaaaa atcgtcaggc accttttccg 3489541 gcgctacatc aaaagtaacc ggaaagacat acagcggaaa aacgtctaaa gcctatgttg 3489601 gcggacgtta tgtttcagtc aatcattact atcacgcagg tttcgcgcca tcaggatggt 3489661 ttggatatta tagcggattt acaatgggta tgttcatgat cagcatgatg cacccatggg 3489721 gttacaccta tcatccagtc ggaggccccg gttatgtttc ttatggcgct tcacccattg 3489781 cctggatcgt tgatatcatc gctttgatta ttattttaat cattgtcatc gcattgattc 3489841 gcgcatttaa agcaccgaag acgtacagaa ggagatttta ggcaatgaga ttaatattaa 3489901 atgagcaaga aattgtagac ggaatttgcg tgtatatttc caatgaagaa gatatctacc 3489961 ctgaagacgt tgaagtaaaa gaactatcgt acaacaagcg tacagggttc ttcgctgaag 3490021 ctacatttgg cctgcaccac aagcagctta tgtcagatga catttcagaa ggcattattc 3490081 agttcttaga ggaataccac aacttcaatc cggacgttac cgtcgttgaa ttgcaatttg 3490141 ataagaaaaa aggcttctcc gccttggttt ttgtcaacga agcagaagaa taaaaatgtc 3490201 ttaatcaaac cttactccgc gcgggtaagg tttttttaat ggtttctctg agcataaagt 3490261 tatttcgttt ttcctaaact cagcggatct gtgatcatct cttttggcta taaagtttcc 3490321 gttttttcaa aacaaatgtt tcaaatgaga taggaaatgg gtactaatct attaactttg 3490381 ttacatattt ttagatactc attggctcaa caactgagga ggagacattt gtgaagaaag 3490441 acacaaggaa atatatgatc tactttttcg gcgctttagg gggactgcta tatggttacg 3490501 atacaggtgt tatctccgga gcactcctgt ttatcaataa cgatattcct ttaacgacat 3490561 tgacagaagg attggttgtc agcatgctgc tccttggcgc gattttcggt tctgccttga 3490621 gcggcacatg ctcagaccgc tggggcagga gaaaggttgt atttgtcctt tccatcattt 3490681 ttattatcgg tgcgctcgct tgcgcatttt ctcaaacaat cggcatgctg attgcatcta 3490741 gggtgatact cgggttggcc gtcggcggtt caacggcact tgtgcccgtg tatctttccg 3490801 aaatggcacc gacgaaaatt cgcgggacac tcggcacaat gaacaactta atgattgtca 3490861 ccgggatttt gctcgcctat atcgttaact acctgttcac accgtttgaa gcgtggcgct 3490921 ggatggtcgg tctggctgca gtgcctgccg tgcttctatt aatcggcatc gccttcatgc 3490981 cggaatcgcc aagatggctc gtgaagcgcg gcagcgaaga agaagcgaga cgcatcatga 3491041 acatcactca tgaccccaaa gacatcgaaa tggaattggc agagatgaag caaggggaag 3491101 cggagaaaaa agaaacgaca cttggcgtgc tgaaagccaa gtggattcgc cctatgcttc 3491161 tgattggcgt cggccttgcc attttccagc aggcagtcgg cattaacacg gtcatctact 3491221 acgcgccaac catttttacg aaggccggtc ttggcacatc agcttcggcg ctcggcacaa 3491281 tgggaatcgg catcctcaac gtcatcatgt gtatcactgc catgatctta attgaccgtg 3491341 tcggccgcaa aaaacttctg atctggggaa gtgtcggcat cacactgagc cttgctgctt 3491401 tatcaggcgt gctcctgaca ctggggcttt ccgcatcaac agcgtggatg acagtagtct 3491461 ttctcggtgt ctatatcgtc ttttaccagg cgacatgggg tccggtagtg tgggtgctca 3491521 tgcctgagct cttcccgtcc aaagcacgcg gagccgcgac agggttcacg actttggtgt 3491581 tatcggcggc taacctgatc gtgtcgcttg tcttcccgct gatgctaagc gcgatgggca 3491641 tcgcatgggt ctttatggtt ttctcagtca tttgtcttct ctcatttttc ttcgcgttct 3491701 acatggtacc ggaaaccaaa gggaaaagct tggaggaaat tgaagcaagc ctgaaaaaac 3491761 ggtttaaaaa gaagaaaagc acccaaaacc aagtgctgaa tgagcgtaca ttataaaaaa 3491821 aggaatcgtc tccttatgag acgattcctt tttctgttta caccatgacc ttgcaaatat 3491881 tgttcgtaaa ttccacaggg tcctgaatcg gcaggccttc gatgaggagc gcctgattgt 3491941 acagaaggtt tgtgtacagg ctcagcttct ctttatcttg ttcaaacgcg tcctgcagtg 3492001 tttggaatac ctcgtgattt gggttgattt ccagcacttt ttccgccttc acattttggc 3492061 tgtcaggcat cgcatttaag attttttcca tctcaattgt cacttcgccg tcagcagcaa 3492121 ggcagactgg atgtgattta agccgttttg agattctgac gtttttcact ttgtctgaca 3492181 gaatgttttt catttcctca aacagatcct tatacttgct ttcctcttcc tcggactgct 3492241 tttgatcctc atccgtgtct atgccaaggt ctccgcttga tacggacttg aattcttttt 3492301 cctgataaga agccagcatt ttaattgcaa actcatcgat gtcctcagta aagtagagga 3492361 tttcatagcc tttgtccgcc accatttccg tttgcggcag tttctcaatg cggtcgtaag 3492421 aatcaccggt cgcgtaataa atgaatttct gctcctctgg cattctggaa acatactcgt 3492481 ctaagctgac cagttttttc tcttttgaag agtagaataa gaggagatcc ttcaattgat 3492541 ccttattcgc gccaaaatca ttgtacacgc cgaatttcag ctgtctgccg aacgacttgt 3492601 agaacgtctc gtatttctcg cggtcttttt tcaacaggct ttgcagctcg cttttgattt 3492661 tcttgctgat gtttttcgcg atcagcttca gctggcggtc atgctgcagc atttctctgg 3492721 aaatattcag cgacagatcc tcagaatcga ccatgccctt cacaaagctg aagtggtccg 3492781 gtagcaggtc tgcgcactta ttcatgatca gcacgccatt ggaatacagc tccaagcctt 3492841 tctcatattc cttggaatag tagtcaaacg gcatgttttc agggacgaat agaatcgcgt 3492901 tgtagcgaac cgctccatcc acgctgatat gaacgtgtgt cagcggttta tcaaacccgt 3492961 aatgcttttc agcatagaat ttttcataat cctcatctgt cagctcgctt ttgttttttc 3493021 tccagatcgg caccatgctg ttgaccgtct gctcttcctg cacctcttca aattcatttt 3493081 cgctgccttc cttcggctta ttaatggttg tatccatttt gatcgggtag cgaatgaagt 3493141 cggagtactt cttgatgatc gcttttaaac gatattcctc taaaaactcg tcatagctgt 3493201 catcttctgt gttctctttg attttcagga taatgtctgt accgacagaa tccttttcac 3493261 acggctcaat cgtatagccg tctgcacccg cagactccca tttataagcc tcttcgctgc 3493321 caagcgcttt actgatgact gtcacgacat cggcaaccat aaatgccgcg taaaaaccga 3493381 caccgaactg cccgataatg tcatgtccgt ctttcagctc gttttccttt ttaaacgcga 3493441 gggaaccgct ttttgcaatt gttccaagat gctgttcaag ctcatccttt gtcattccga 3493501 tccccgtatc agagatggtt aatgttctcg catctttgtc agctgcgacc tttatgtagt 3493561 aactgtcttt atcaaacgta agcgcatcgt ccgtaagcgc tttgtaatag attttgtcaa 3493621 tcgcatcact cgaattggag attaactcgc gcaggaaaat ttctttttgg gtataaatgg 3493681 agttaatcat catatccagc aagcgtttag actctgcttt aaactctttt ttcgccactc 3493741 ttgatcgctc ctttaccatt atgtaaaccc ttttcagcat ctatttatca cataagatga 3493801 caattgtcaa ttagattgat agatgcatat atatgtaaat ttaacattag ttggatttgt 3493861 tttcactctt tttctcactc attctcataa aaaagagagg cttcatcatc ctctcttttt 3493921 ttctgtgtca ttccaacggc caaactcccg cttcatccat atatgcaccg ggtagaaaaa 3493981 caaaccgaac ggtatcaaaa acaaaagatt atgccatgaa gcattcagaa atgcgcttgc 3494041 agtcaccggg aacgtaatct cttgcaataa aaaagagatg acagtcagca caacaaatgc 3494101 agatggaatg gtcacgatgc aataaaactt gagctccttc ttatgctgta ccttcaaaca 3494161 tacaaacctc ccaacaattt ctaattcatc ttaacatatg ctggcctttc ttttctcgca 3494221 tgtttatcac tgcacatagc gggaagacaa atagaaaaag gaggtctcgt atcatgggaa 3494281 gacttgaaaa caaaacagca gttatcacag gcgccgcgac aggcattggt caagcgacgg 3494341 cggaggtttt tgccaatgaa ggcgcgcgtg tgatcatcgg agatatcaat aaagatcaaa 3494401 tggaagaaac agttgacgca atcagaaaaa acggaggaca ggccgaatcc tttcacctcg 3494461 atgtgtcaga tgaaaacagt gtgaaagcat ttgctgatca aatcaaggat gcatgcggaa 3494521 cgattgatat tctgtttaat aatgccggcg ttgatcagga aggcggaaag gtgcacgaat 3494581 atccggttga cctgtttgac cgcattatcg ccgtcgacct gcgcggcaca ttcctttgca 3494641 gcaaatattt gattccgctc atgctcgaaa atggaggctc catcatcaac acctcctcca 3494701 tgtcaggccg tgccgcggac cttgaccgct ccggctacaa cgccgcaaaa ggcggtatca 3494761 ccaacctgac aaaggcaatg gcaatcgact acgcacgaaa cggcatccgc gtcaattcca 3494821 tttcaccggg cacgatcgaa acaccgctga ttgacaaatt agcaggcaca aaagaacagg 3494881 aaatgggcga acaattccgc gaagccaaca aatggatcac gccgctcgga cgtcttggcc 3494941 agcccaaaga aatggcaaca gtggcactgt tcctcgcatc agacgacagc tcatacgtca 3495001 caggagaaga catcaccgca gacggcggca tcatggcgta cacatggcct gggaagatgc 3495061 tgattgagga gaaatggaag gaagaaacga aataagagag ggagccccct ctctttttgt 3495121 cttttaaagc aatacaacct tatatttctt cacatccaaa aactgcaaaa actccctcgc 3495181 cagcacttca ggcggatgcg cctttccttc atccagccga tacaaaagca acccgataat 3495241 cattgcggat acataatggg cataaagctt tttctctgcg tgaatatcag tttgctgatg 3495301 cagataaaac gattccagcg ctttgaacat atcaggtatc acatgaggaa caccccattc 3495361 ccgattgaga aaatggacaa tgggcatgtt tgacaaagca gaaagcagaa tggcgagcgc 3495421 cttctccgct tcctttaagg aaaattcatt cgggctggag gcaatcgtca ggtgatcaat 3495481 gatctccgca catgatcgct gtatcatggt ttggagcaat tcctccttat tggcatagtg 3495541 atcataaaag gttgcacggc ggatattgct tttacgcgta atatctgaaa tcgtgatgcc 3495601 cgcgtagtct tgtttctccg ccaatacatc cagaaatgcc ttctgcagcg cctctctcgt 3495661 tcgaaccacc cgcctgtcga tttgcttctc cttctctcgc tctcctggca cagcttttcc 3495721 aaacagccaa taaaaccgct tttgagaaac aagctcccat accttctggc tgatggcttc 3495781 aggagacgcg gccgcatcct cattcagcca atacaggata atcgcgtacg tgtacaaggc 3495841 ccgataatgt ccataaatgt cccgttcaat cggcgttaaa ttcacatgga tcggagccag 3495901 cagcacatcc tgctgaaaca catccttaaa aaaacgatga aaatgtcctc tgttcatcat 3495961 cacagaaaaa aaggaacgat gctcatgaac aaaggacagc gtcggatgca ccgtttgccg 3496021 ttttttgttc aaatgaaggg tatccatatg actgaaggcg tcaaaaagcg ctttgcccag 3496081 tccttccttc atgtcttcga tcacatcctc aatgattgaa aacttatcct cataataaag 3496141 gtagagcgat ccgcggctca ctttggcctt ctcagcgatt tctttcattg tgatgtgttg 3496201 aatatctcta tctttcaata aagccagcag cgcctctttc acttgagctt cggcagattc 3496261 cggcacaaaa gacacctcca atcattagac agatcttaga tatatgtacg gtaacgtata 3496321 gatggttcac cgttgtcttt cttacagaaa aggtaccacc ttataatagg tccgagaaaa 3496381 gaagaaagca aatgaggggg attttacaat ggaacagcaa gtaaaggacg acatccagcg 3496441 tgtctttcag cttcagaaaa aacagcaaaa agccttgcgc gcttcaacag cggaacagcg 3496501 gagagaaaag cttcaacgct ttttagattc cgtcatcgcc catgaagaag aaatcatcga 3496561 agcgatccgc aaagacgtcc gcaaaccata tcacgaagtc aaaaaagcgg aaatcgaagg 3496621 aacaaaaaaa gcgattagag ataatatgaa taacctggaa caatggatgg cgcctaaaga 3496681 agtcggttca tcgttaagcc ctgacgcaaa cggaattctt atgtacgagc ctaaaggcgt 3496741 cacactcatc ctcggcccgt ggaactatcc gtttatgctg acgatggcgc cgcttgccgc 3496801 ttctctcgca gccggaaaca gcgcgattgt gaagctgtcc gatttcacga tgaacacgag 3496861 caacattgct gctaaagtaa taagagacgc ttttgatgaa aaagaagtcg cgatttttga 3496921 aggagaggtt gaggtggcaa ccgaactact tgatcagccg ttcgaccata ttttcttcac 3496981 tggaagcaca aatgtcggga aaattgtcat gacagcggct gccaaacact tggcatctgt 3497041 cacacttgag cttggcggca agagcccgac gatcattgac agtgaatacg atctgatgga 3497101 cgcagcgaaa aagatcgccg tcgggaaatt cgtaaacgcc ggccaaacct gcatcgcacc 3497161 tgattacctg ttcattaaaa aagacgttca ggacaggttc gcggggattt tacaaacagt 3497221 cgtcaacgct ggatttatgg aggatgatca taccccagac cgcagcaaat ttacgcagat 3497281 cgtcaatgac cgcaacttca accgcgtcaa agatctgttc gacgatgcca tcgaaagagg 3497341 ggcggaagtg gtgttcggcg gcgtattcga tgccagcgac cgcacgatct cgccaaccgt 3497401 tttgaaaaac gtcacgcctg acatgaaaat catgcaggag gaaatcttcg catcgatcct 3497461 gccaatgatg aactatgaag acatcgacga ggtcatcgat tacgtaaatg accgcgataa 3497521 accgcttgca ctttatgtgt tcagcaaaaa ccaagatctg attgacaacg tccttcagca 3497581 cacgacatca ggaaatgccg ccatcaatga tgtcgtcgtc catttcagtg acgtcaacct 3497641 gccattcggc ggcgtcaaca caagcggaat cggctcctat catggggtat acggattcaa 3497701 agagttttct catgagaagg gtgtatttat tcaggccgct gaataatcgc atgatcaaaa 3497761 ggcgcttcct tagaggagcg ccttttattg taactccttg accaaaagca attcatcacg 3497821 gataggtatt ttattatctg ccagtaaagg aatttcgggc ttcatctttc tggccgtctc 3497881 gactgcattc acaaatagtc gatccaaccg gtaccctctc ttctgataaa acgctaatgc 3497941 atgaatatta tcattggttg tgatcagttt tatttgtttg atatttctct ctctgcatgc 3498001 ttcctcggct ttctctagca gagctgttcc gatcccttta ttctcaatga cactatccag 3498061 cgaaatgatt tcacaggcat cttcttcaaa tatgtatgta ataaggccaa caatctggtt 3498121 atcatcgttg agcattccat aaccatctaa ttcatcgcag ttataaatac cgctagaaat 3498181 aaccatttgc ggactgcccc agtgtttttg aaaaaacgcg gaaacaagat ctttaggtac 3498241 ctggcatgtc ggaataatat tcatattttc ctccttttag ctgaacaaaa ataagagaat 3498301 taacaaccta ttttatgtca ttaatcccct tatctagtat ttactagaac ttataacttg 3498361 tcaaaagctg tctgaatacc aattgcgtgg attgataagg atcaaaatct gaatcctgag 3498421 attggaagat ttgctctggg gtcaatgtct ctgcgttctc tgataacgtt tgaatcagac 3498481 tttccaaata tccatttaac tctgatttgg acgattcatg tagggattga tgatttacag 3498541 cgagttctct aaatctgtta tcactgatta atttttttcg aagagctgct agcatcaagt 3498601 caagccatgc aggctggcca aatgtaatat ttaaagctaa cgttgcttga tcagatttgg 3498661 tggagtgcca taaacctctt ggcaaataca gcatggttcc cggtgttaaa ttaacgattt 3498721 ctgcatctgg cagatcctct tttggcggat ctcctttcca atatgactgt aaatcatcag 3498781 gatagtaagg agcctctgat aaatcatagt gctgcattgg attgctcaca ttttcattct 3498841 tggcaagctt ccatgttttc tcaccttgaa tttgaaaaat caagttggtg taggcgtcaa 3498901 aatgggcttt gaatcccccg ccatttttcg ccgcgtaaac aatggctttg gaagaagtac 3498961 ccgcaggcag tcttaattcc gctttgagtt tttctatcca ccttctgact tggggaataa 3499021 ataggtcggt gaaatcaaac tctaatgcag cccctttttc ataccactct aaagcctctg 3499081 caggtgacac aagaaatctg tctgtgatcc cttcagattc ttcaatcaca gcatcaccaa 3499141 cgaccatgac tggattattg tagatagcca atacgttttc tagcgttcta accttttcaa 3499201 accccggtat gcttgtaaat ctctccactt ctcctctggc taccaaaggt tttacaggcc 3499261 aatattcttc taaaaactca ctcatcgtta caggactgat gatagactcc aaaaccgatt 3499321 cggttacagc actcatatta tccctcccaa aaaaagtaac ttcaccacaa agatataaca 3499381 tttttttcta aaagtaaata ttgacagaat tatcagagga ttataatatt tagttgtgcg 3499441 tgatagccta tttttttaca aggaaggagg gaaaaggatg aaaaaggctt ataagaaacc 3499501 tcgtcttttt gaactgcgcc gtgctgtagc agctggcggc cattaatctc atatagcatt 3499561 tgacatctag tactctattt taggagggat gctcaatgaa aaaagcttat aagaaacctc 3499621 gcctttttga actgcgccgt gctgtagcag ctggcggcca ttaatctcat atagcatttg 3499681 acatctagta ctctatttta ggagggatgc tcaatgaaaa aagcttataa gaaacctcgc 3499741 ctttttgaat tgcgccgcgc tgtagcagct ggcggtcatt aatcttatcc aaaacgatta 3499801 acgtttgagg ctatcacgcc aacttgataa ggaggatgct gaagatgatt acggctgaag 3499861 aatgcagaac gtacaaagaa tttgttgatc tttaccaatc ctatctttac cccttgcttg 3499921 gcgccagact gtcccggatg tattccccca aaaacaaagt cattatcgat atgggcacag 3499981 gtccaggtta tttaagcatt cagttggcta aaagaacaaa tgcgcacgtg catgctgtcg 3500041 atattaaccc ggccatgcat gaaatcgctc aagaagaagc taaaaaaagc ggagtaagca 3500101 gcctgatttc atttgatttg gaagatgtcc accatttatc ttacgctgac caatatgctg 3500161 acttcatcgt ctcctactct tgcctgcatc attgggaaga cgttgttaaa ggacttaaag 3500221 agtgctatag agttctggct ccgggcggaa aaattgtcat tttggataca tttaatcccc 3500281 aaggaagcca tttagagatt atgcgaaaac aaatcaaaga accggaatac ttcaggtttg 3500341 taagagaggc atttgaagaa agttattcct ttgaagacat tcaccagttt gttcaggatg 3500401 ccggcattcc caattattca ttagaaacct ttcacttttt accggaggat tttatagaaa 3500461 gcttagatga gctggaggat gctcccctgt gggaacaaaa tgatcaaagt actgatcatg 3500521 aaattgagtc tgtcacatgg atgttaacga tagaaaaaga aaaggaaggt gcattgtaat 3500581 gatcaatgaa tcaactgttt tatccaaaaa tccagaaatg ccatcaagaa aatatttgaa 3500641 aagcattatt atagagccgg gcatcacttt aaatgaaatg gcatcagata tttataacca 3500701 tatcgacggc aaggtcagca tacatgatat ttgctcaaaa atcgtcaatg aatatgatgt 3500761 tgattatcaa acctgcttag aagattgtat ggagctgttt gagttgctta ttgatcatga 3500821 agcaatcaaa gttaagcagg gggcatgaga attggaaaaa caaaaagtgc ttgctttacc 3500881 agacgatgta catgagctga gtacacaccg ttctaaatca atcgtaaatt acatcatcac 3500941 tctgcttgcc tttgccaaaa aacaaggatt gactcatcaa gatattgtaa gctggattca 3501001 cgagcaatat gaggaaagag gatattatga tgagtggaga cacattaaca gccaacaacc 3501061 agttggatca tttgtggaac tctttataaa aggaagacgt ttactttatg acaaaattga 3501121 attgtttgaa acagaagata aatatgtcgt aaatacccac acttggtatg aaaaagaacc 3501181 tagtgaggcc tttttttatt ttgaaattga tcccgaagaa ttttctgcgt acgcttccat 3501241 tctcgcaatc gaaaacgcaa aacgtctcgg aattaaaatc gatattgtaa aagaaacaga 3501301 tgtagagaca gcttatatct ataaacatca ataacgctat tgggagggag acatatgtgc 3501361 gggctcgcgg gtattataaa tctggctgct ccccgttctc aggaatgtac ctttcatata 3501421 ttgaaaggca tggcagatgc catcagctat aggggaccgg atgatgaaca atatcatatt 3501481 gattccaaag tcggctttgc atttcggcga ttgtccattc ttgaccttgt aaatggacag 3501541 cagccctttt taaatgagga tggatcaatc gtcgttatgg taaatggaga aatttataac 3501601 tataaagaac tgaaggcttc tttacacaat catatgttta aaacgacatc tgattgtgaa 3501661 gtaattgttc atttatatga agaaaaaggg attggatttg tagacgacat catcggaatg 3501721 ttttcaatag ccatttggga caaaaataaa aacaaagtat ttttagttcg tgaccgcttt 3501781 gggattaaac cgctttttta cacagagcta aaacacgagc ttatatttgc ctctgaaata 3501841 aaatccctat tttctcatcc tcactgtccc cgccaattta attggaaaga agcactctca 3501901 gacatttggc taagcgggga agcagccagt aatcataaag aaaccacttc cttttttgta 3501961 aacatccaaa atctcgatgc tggccattat ctcgaaatta atttgacaac aaatgaacga 3502021 aaaacagcaa gctattggtc tttacaggat attttgctca ggcaaggcta tcgtgagaat 3502081 ctccatcccg atgacctgat tgaaggatat agagaactgc tggcagattc agtccataga 3502141 tgtttacaaa gcgacgttga agtcgggttg tttcttagcg gtggcattga ttcagctgca 3502201 gtcgcacatt ttgctgcaga aaaacaggat ctccatacgt ttacagtatt aagccaaagt 3502261 acatttacaa atgaagatgc aaaatatgcc cattggctgg ctaaagattt acaccttcca 3502321 aatcatcagg ttctctatca attagggaac gatgagttat tacaaccaga gtcatataaa 3502381 catttgttat ggatctgtga aacaccgttt tgcggaccgg aacaattata taagtttcat 3502441 ttacataagt atgccaaagc gataaggcca aacctgaaag tcatgctgac cggccagggc 3502501 agcgacgaat ttaacggcgg ttacagcacg acactttcac cagccgagaa cccaagttgg 3502561 gaaggattta ttgaatcggt caatacgatg gagatgaacc ggctgcatcg gctgcaggga 3502621 aatatcttta gagtgtggga ggagcatttt ggactttctc ctataaacct ttcttattta 3502681 aagagcaatg attccagcca agcagatcct tggcaatcgt atgtcctgac aaaataccgt 3502741 gatctgcaaa tgtataattg ctggcatgaa gatcggatcg ccgcggctaa tcatatcgaa 3502801 aaccgtgtac cgttcttgga ccatcggctt gttgaatggg tttgcggaat acctgatgga 3502861 ctccgtaaag acttgttatg ggataagtcg gtattgcgaa aatcattaac aaatgagctg 3502921 catacaagct atacccaccg gccaaaggtt ccttttttct atggtaagga cgtgagatat 3502981 acacataaaa tgatgtttca tcttctgaag aaaaacaatt atcagcttat agaggaggcc 3503041 ttctctcaca gcgatgcctc cagcataata caggttgaac acattcatgc catcatgaca 3503101 tatttggagg atgatcctga gtttacaaat tttgaatttt tattaagact ggtgaacatg 3503161 ggacttttat caaaaatgac taaagaaacc ccttctgttc aattagacat aaccagccat 3503221 ttagaatcga taacaataaa agactggcac tcacaggaag gtgatattgc cagtcgttta 3503281 aatatctcag ccaataagtg tgaaggacaa gatattttgg cgctaaaccc tggcgtcact 3503341 ctgttaaggc cggaaagcga tagtgagcat tgcatctaca ttgcggaaga aggatttatt 3503401 cagtttattg tttcggagga agacgtcgga gcttggctgc atattctctg cgatattaat 3503461 ggaaaagaca cacttcatac gattttagac agacatggtg tcagccttga agaagtggcc 3503521 aaatatattc aagaagccat cgaacacaat atcattttga tcaaacaaaa aaatctgcca 3503581 gaaggagcat atagatgagc atcttttatt cgttttccgc acttagggga ttagcaatgg 3503641 ggattttttc gcctatttgg attctttatc tgatatctaa agattatgat ttccttcaga 3503701 ttggattaat gggagcggta cttgaaattg ctaagcttat atttgaagtt ccttccggcg 3503761 tttttgctga tcgttatgga attaaaattt caattgccag ttcattcttt ttctccatcc 3503821 ttacatgggc cttcttccct tttatcgatt cagctgctat ttgcatactg gctatgatca 3503881 tatgggcttt atcagattcc ttaatttccg gttcttttga aacttggatg agccgtgtcg 3503941 caggggaaga tcgattcggc aaagaaatga tgaaaaacac acaattgcta atcacttttt 3504001 taattattgg aagtattgcc agcgggtatt tgtattcatt aaatatctat tttcctttcc 3504061 tgctcgttat ggtgatctac ttattactat ttatttggat gtctgtattt attaaagtcc 3504121 cttctgtttc cgaaacaaat catggggatc agaaccaaca tgattcgata aagattatca 3504181 aagaaagttt aaaaattatc tttaacaaaa aaagggttct tttaatcgtc atagccggtt 3504241 tctttacagc cacagcctat gacacaattt cccgttactg gcagcctttt ttgagtgatt 3504301 taggcttttc agaaaagtca ctgggatata tttttgccct aggagggttt accgctctcg 3504361 ttcttttgac attaaccatc aggttcgaaa agaagatcga aaaaaatcca tatctcgctt 3504421 taacctcatt ggattccatg ggcatggtca tgacttttct attgtctaga gcattcaggc 3504481 cgctgggcat tccatgtaca gcgtttttgc ttgcaattga agatattcat catccgatcg 3504541 taacaagtta cttaaataag tttttccccg attcatacaa gaacacactt ttctcgttaa 3504601 actcaggggt aggagcaatt ggagaaattc tttccggtgt cattttcggc atcatttccg 3504661 cagcctttgg gctctctgcc atgtttgttg ttgtagctgt atttctatta atccctatta 3504721 tcctttatac gatagtgcct aagattaaag acaatgatat gaaagttcag attgaaaaat 3504781 cccagcaagt gtaaatgttt tgtatcacag taagaagacc ttcttattaa aagaaggtct 3504841 tctgctattc tattcagtta tttcccaaaa gccatcagct tcgtataact tccaatataa 3504901 agtgttccgt cctcagcgag ctgaggagaa gacacgacgt tgctgtcggt ttgatagctc 3504961 cataattcat tgccgtttgc gtctgccgca taaaccttca tatcatctga cccgaaataa 3505021 accgttccct tcgcgtcaat cagcggcgcc gttctgacag ggccgtctgt gtagaatgac 3505081 cagttcatat ccccgttttt gctgatggaa aacagctcgc cgcttcctga gccgatgtag 3505141 atattgccat tatgatcaat cgcaggagat gagctggaga acccgtttag cgggaatgtc 3505201 catttcaaac tgcctgttga tgtataagca tacagctgtc catcttggtt gccggcataa 3505261 atgtttccgt ccttatcaat caccggatat cctttaaacg catttgacgt cgttctggac 3505321 catttcacct gtccggttcc ggagttgatc gcataaaaca cgtaattata tgtgccgaca 3505381 tacacggtgc cgtttttggc aagcaccggc acagagctga cgaccccatt tgttttcaac 3505441 ttccagcgct ctgtccaggt tgattttgac gtcggtttga tcgcgtgaac ataattatca 3505501 agtgttgaga aatacaacgt cccgtctgaa ccgatcaccg tttcagagct tggcccgccg 3505561 cttaacggaa ccgttgttaa aatttctccc gtttctttgt caataaaata aatctttttg 3505621 tcataggatg ccaaatagat aacgccgttg gtcccaagta caggagattg cgtatatgtt 3505681 tttccaagat tgcccgtcac ccatttgact gagccgtctg gattaaaggc tttcatttcc 3505741 ccgtctctgg aatgaagata tactgtgccg tctccgtcaa tcacagcccc cgctccattt 3505801 tgcggagtcg ttctgatgtc gttttgccat ttcagcgtcc cgtctgtatt tccggcgaac 3505861 cggctttcgc gtgaccagtt aaacatggca ggcgccatcg cttgtacatc atatcttcct 3505921 ggcaaaaagc cagatgctcc attattttga gaaaacaccg tttccgccgc ataagcagct 3505981 gtcggctgaa gcactttggc agcgggcaca tcagaaacag cgccggccga aacagccgcc 3506041 gccaccgcag ctcccgcaat caaagctttc atacgaaatg acttgaccat cattgagacc 3506101 cccattatat gtaacttcta atttgtgacc atcataacat attcatccat tttataaatc 3506161 tatttcacaa aaacatcaca aactagaaaa ctatgtaaga gtattcacgg acgttttttc 3506221 agcacccgat cgaaatgcag ccacaaacca aatgacgttg acagcagccg cagcgagact 3506281 aactcccaaa acaaagatca cctcagaaag cagatggtca ctaaagaaac taaacatcaa 3506341 gataaaaccg gccgaagaca aatgaatcaa aagcccgaag ccgcaaagca ccgccatgac 3506401 atacctcatt gcatcgactc cgagcatata aacgagaaat ggaatgaaat acaagacaag 3506461 gatcataccg acagctgacc acatgccagc tgaattaaac tgattggccg ccgctcccgt 3506521 tccggccagc ggcgaaagtg aagccgccac aatcacggcg caaaaaagaa acgcagaaat 3506581 ggttgtcatg atcgccacgc tatttttttt tgacatcaaa ctcctccttt aatagaaata 3506641 ttaacctttt ttattataag taagttgaat gttatattca ttatattttt aaaaaattcc 3506701 agaatacata cacaaatgct atgcttcttt ctagtatatt tatatagtaa aaaacaaagg 3506761 ataaaagact catttttctg taatatcagg attttatcac cataccatat tgcatgtaca 3506821 tgtttttcaa agtatactat tccagattaa ttcagaggag agagaaaaat acatggaaaa 3506881 accagcagga ttttggattc gttttttagc ttattttatt gacggcatta ttgtatctgt 3506941 tcctagttat attattctat ttattatcaa ttctgtgttt gtagctgggg ctgtggcaac 3507001 aaacccttac atgacggaag aagagtattt agtgaaatac atgacgcttg catttttgcc 3507061 tactatgctg atcatgatcg tcatcagcgt gttatattac gggctgctca cagcttctaa 3507121 aatgcaaggc acacttggca aaaaaattct tggcctgaaa gtggtcaatg aacaaggtga 3507181 acgggtttct gtcggacagg gaattggccg ttactttgcc tatatcttat ctggaatcat 3507241 cttttatatc gggtttatca tgatcgcctt tggagagaaa aaaggcctgc atgacatcat 3507301 ttgcaaaaca cgtgtcgtgt ataaataata gaaaaaagtc tagacgccaa taggcatcta 3507361 gacttttgtt ttctttgcaa taggctgcca cgacagatac gtagcgcttc tccacaacca 3507421 ctcaaacggc cccatccgaa agacacgaag ccaaaggtgg ctgaagacca tttgaacggc 3507481 acaaacagca attgtaatga gcacaccggc agcagggtac acttttccat acaggcccaa 3507541 gccgtaatga taaaaaatcc aagtacacac aatagactgc atcaaataat tggtaaatgc 3507601 catcctccca acagcggaga atgattgcag cactgttctc actcttgttt tatgataaag 3507661 atagacaacc gttgtaacat agaaaaacat gaggaaaggc gcgccaatca gcaaacatat 3507721 ttctttatcc gttacactgt acagcacctg ggcgccgatg ccgatgacaa gcccagccat 3507781 ccataatcgt tttaatcctt tgcgatgctt ttccggttca tgcaaatacc gtgattttgc 3507841 tgccgcagct cccagcaaaa acatgctgaa atatggaatg gatgcaaaga agtagttgag 3507901 cggattatac gtaagcatgc cattcgaaga catgtaaaca agacggtcgt ggatccgctg 3507961 ttctgcaata tccttcaggc tgccgcttcc ataaacatga atcgcttgtt ttgcctgctg 3508021 tgttaccgct tgtacccatt cctgtccgtt tgattgatca aaacttgtca acatgaacgg 3508081 aatggaaaac agaagataca aagagaccgc ccatatcagc agtgttttcg gctttgcttt 3508141 tcgaaacaag agcaggacaa atccgagcag ggcatattct gttaaaatat ccccgtccca 3508201 tatcaaaaag gcatgaatcg ttccaaacaa gagaagcgcc attaaccttc tcacatataa 3508261 cggaacaaac cgtttccctt tgttttctgc tctctccatc atgacaacca tgccaaatcc 3508321 aaataaaaag gaaaacaata aaatacattt tgtttgaatg aagaatttca gtatgtctgc 3508381 ggcggcaaaa tcagcttcag accacttatc catgaaaaaa ttctcttttc caagcataga 3508441 caaatacata tccggataac tgaaatgtgc cagattgaca aataagatgc cgaaaatcgc 3508501 cattcctctc agcacatcaa gcacaccgat ccgctcattt gttaaagtcg gctgtaatga 3508561 agacatagcc atcacgctcc ttttttctgt accttaaggg taggaaaaaa tgaagcgcgg 3508621 taacatcgat ttaggtgtca ggccggcatg aaaaccttac aatcttgtca tctttatggt 3508681 ttcatcacct ttaaatctaa tgcttcgata ttctgcaaaa tgcgatcaaa gcgcaaagcc 3508741 tgaggctcac atgggaagat gtggccttca tacgggtcgc ctaacgtccg gaaaaacggt 3508801 tcaaataaac caggaaccaa tacgcccacc atctttgtat agtgagaatc aaggcgatag 3508861 gagtgaacgg tatttgcagg gacatgcagg aaatctcccg gattcagctg aatttcctgg 3508921 ccatctgtcc acatcgtcat ctggccttca aggcaataaa atgtttctgt atgatattca 3508981 tggtagtgat caacgattcg gtcaccttta gggccttcag atgatacgac gataaactgg 3509041 ccatctgtat ttttttgtgc agccacaatg cggtgaagct gatctccagt caacagacga 3509101 tctccttctc cagattcaag aacgtatgga accgctccat ctggcagctc tgtaagttcc 3509161 gctaatttgg ccgaacatgc aggctttgct tcatctagaa atacaatgtc cgctacagcg 3509221 gctgcttctg caaatcgctc gtttgagact tcttcgcttg cgtacggcgg atgttcagcg 3509281 tgatcatacg gattcccaat aacggaatac aagtgcgcta cgtttccttt catcgtgtaa 3509341 gacaccagtc ttgttctgtg gctctgcatc cggtagctgt gcggtgttcc cgccggaatg 3509401 ttggcataat cacctgatat taataaatag cgttcaccat caagtgtcag ttccagtttc 3509461 ccgtccaaaa cgagaattcc ttcatgtgtg tccttgtgga cgtgaagcgg aaaggcatct 3509521 ccttttcccc cggaaagaag cacgatctca aacaaatcac ctgtgctcct cccattcgcc 3509581 atcaccgtgg caacctgtct gccgaacaga tagcgctcgc cttctccgct ccggagcaaa 3509641 taaggcattt tttctttagg caatgaatgt gtacataatg ttttcatatt atcgcttcct 3509701 ccaatttaga ccagtctata tattatcatt catttgtcta gaccgttcta tataattgta 3509761 ggagaaagga taacaaaatg ctaccctttt tttctcacca gcactggtat ttgttcggca 3509821 atgagaagaa gaggcgtttt gtctttattc gttaacgaaa gcatgatgcc gccctcaatc 3509881 atcgaattaa tcagcgttcc aagctgattt gcttcttctt ctgcaaatcc gttttccatt 3509941 aattttctgg caaaaaccgc ttcccagctt ttaaacacct tcatgcaaac cgtccgcagc 3510001 ggttcactga ttaacgctgt ctcactcgcc agcaaaccga ctggaatacc tttaatgctt 3510061 tctgtgttgt caaattggct ggctgttttt ttgataaaaa gctgaatcgc ttcaacagga 3510121 tcagaggatt catccatgct ttgctgtatc agatgttcaa cgatcttacc tgtatatgta 3510181 accgcttcaa ttgctagttc ttctttgcca ttcggaaaaa agtgataaag cgatcctttt 3510241 ggagcaccgc tttcttttac aatctggttc aaacctgtcg cgtgatatcc ttgcagctgg 3510301 aacagacgtg acgccgtgtg aaggattttt tcacgtgaat ctcctctgct agtcattaaa 3510361 acattccctc ctaggtatgg tagagcgact tatataatat aaaaaagaac cctgtgattg 3510421 tcaaaagggg taagaccctt ccggatgggg taatgtacaa aaacagcgtc taggagggat 3510481 ctctcaatga caatcgatca ttcagtcaca aatacagagc agcttgaaca acagaacccc 3510541 gccataaaaa caaagctcaa actgaaaaag cttaaggatc aggtgatcgt cattaccggc 3510601 gcttcaagcg gtatcggact tgtcacggcg agaatggcag ctgaaaaagg cgcaaaggtc 3510661 gtggcagcag cgcgaaatga agaggcgctg aaggagctca ctgatgaact taaggaaaaa 3510721 gggcacgacg ccatatgggt aaaggcggat gtcggaaaag aagaggacgt caaccgcatc 3510781 gcagaaaccg cgatcagcac attcggccgc tttgatacat gggtcaacaa tgcggccgtc 3510841 tcgactttcg gacacgccat ggacgtcacc gtcgaagaca tgaagcgcat gttcgacaca 3510901 aatttctggg gacctgttta cggaacaaga gcggctgtca aacactacac cggcagaggt 3510961 gtgccgggcg cactcattaa tgtaggaagc ctgttcggag acaggggaac ggtcattcaa 3511021 tccacatatg catctgccaa atttgcgctt cacggctgga cggaaagcat ccgaatggag 3511081 cttgaaaagg aacaggcgcc cgtctcggta acgctcatcc acccgggcag aattgacaca 3511141 ccatataacg agcatgcgca cagctacctc gacaaacagc cggctcatta ccgctccatg 3511201 atctatccgc cggaagcggt cgccgaagcg atcctgtttg ccgccgaaca ccctaagcgc 3511261 gacatgtaca tcggctcaca ggccaaagcc atcgccatgc tgggcgcgct ttttcctcgt 3511321 ctgaccgaca gactgatgga aaaaatcatg tatcacagcc agcatgccga aagaccgtcc 3511381 aatccgagag aagaaagcgc tctttatgat gctggctgcg gtatgcatga cagaggcaca 3511441 aataaaggat ggatgaggtc aagaagctac tacacaaaag cgacgaagcg cccaattgta 3511501 tcggcggctg ttgttgccgg actagtggct tgggctgccg ccaaacgatg cagataatct 3511561 ctgaccataa gaaaaaccca tgctgttcca gcgaaccatg ggtttttcag ctgttaatcg 3511621 ataaaagcct tgttcatacg ctgcagcagc tcgccgaaca tctctttttc ctgtgttgac 3511681 cattctttca gcatctgttc ataacgttca aggcgctttt gctgatcggc ttttaatagt 3511741 tgtttgccga gttttgtaat ggtaaacagg ctgactctcc catcagacgg gtctgagaaa 3511801 cgatagatga gctcctttgc ctctaatgca gctgcttgtc ttgaaagagt agaaatatca 3511861 agcttaaacg attcagccaa ttccttaaca cgagcaggcc caaactcatc caattgtctc 3511921 agtaataagt acgaagatct ctccaaattc cctgttcttt tctccgattg atccagataa 3511981 acagctctcc tgataaaagt cgtcagctca tattcaatta attcaactgg attttgattt 3512041 tgcaatcgct ctcgctccct attccaatct ccggcattga caacatcata tatacttgta 3512101 taatacaaat gtacattaac tgaataaata caagtcgtta tatgactaaa tcaattatta 3512161 tacttgtata gtacaatcat ataaaaagaa agtaaagcga ttcctcagaa ccatcctaga 3512221 agcaagcacc agaaaggagg aagctgttct gattggagag cagcacttga tgtgaaagtc 3512281 atacgaatta ttttgcaagt gttgatatta tatgtatttt ttatgatcgg ggaagccatt 3512341 cagcatctgt ttcatttacc cgtgtcagga agcatcgttg gattggtatt gcttctgatc 3512401 tgcttgggcc tccgtattgt tcccgtctcc atcattgaag acggagcagg gtttttatta 3512461 tccttccttc cattgttgtt catcccggca atgacaggag tgataaacta tccgtctctc 3512521 atttcattca atggcctgat gctgctgatt acagtcgttc tcagcaccat cgtcacgatc 3512581 attgcggctg gattcgccag ccagctatta gagaaaaaag caaaaaaacg ggaggagaaa 3512641 gagaaatgca gcaagcatgt atcgcgatca ttataattct tttaacagtt gccgcttatt 3512701 tagcgatggt caaactctat aagcgattcc cgcttccatt tctgatccct gttctgacaa 3512761 cgacaatttt gattgtagcg gctttgatga tgtttcatgt ttcctatgaa ggctatatga 3512821 tcggggggaa atggatcaat tctttgcttg ggccggctgt tgtggcgctg gcctatccgc 3512881 tttataagca atggcatatc attgtcaaac attgtgttcc cattttaggc ggcgtcctgg 3512941 tcggcttatg catgggaatg atcagcgggc tgatcttcgc agaagcattc gggattgatc 3513001 atgatctctt attatccatt ctgccaaaat cgatcacaac ccctgtcgct attcagatcg 3513061 ccgccggtct tggcggcgtc ccttccatga cagtcgtatt tgtcatgatt gcgggctttt 3513121 caggcgtcat cctcgggccg cttttcctaa aatggcttcg catacgcagc tccctaggac 3513181 aaggcattgc attaggcagc gcctcccatg cactgggtac ctccaaagcg ttggaatatg 3513241 gggaattggc cgtatccatg agttccgtct ccatgacgct ttgtgcggtg ctcggctcat 3513301 tcttcggccc gctcgtcgtc tggctgtttc atatttaaca aagaaagact gccccggggg 3513361 agggcagtct ttttcgttta agaagcaaaa aaatcaatca acggctgaaa gtccttagat 3513421 aaatcaacgt cattcggttc tgcttgaagc aggcggtcaa tcatacgctc cagctcctca 3513481 acatcattct tatccgtata ttcaatgaag tttaagcttt caagccaatc ccgatatgaa 3513541 tgtttggctt tgccatagct gtttccaaag acaaggcaag gtgttttggt gataatcgag 3513601 aaaatcatcg cgtgaaggcg gtcggtaatc accaatttac tggagccgat gcggtccagc 3513661 atctccataa aatgcttttc acgatcagcg taatcgatgg tgtctaccgt atccagcacc 3513721 gtatcggtac gctctgtgta agttgttttt tctgcccatt gcttcatctg tgaaataaaa 3513781 tcttcgtcag tcactttctc cttatccgct cttaaaataa agagaacgcc gtcccgctcg 3513841 agctctcgcg gcacaatatc caaggaaagc accatgtccg gtgtaaagat cacattggag 3513901 ttgaaggtct ctttcacaac atccagtgtt tgcgtctcac gcgcagcaat cgttaagttt 3513961 gtattttgat ggtacgcatc ctgtgttttt ttcttttcct tctgtccttc ctctgtatcc 3514021 tcaaaataaa cggattgtgg cagagaaatt gatttgtagt ctttaaacgc cgaaaagacc 3514081 tttcttctgt cttcctcaat atcgagataa aggtttccta aattccctcc gcctgtaaag 3514141 cagacaatat cgtcttcacg aatgatctcc ttcaccagtt caatgccctc atccgtcgca 3514201 taatccataa tctcaatgta ttcataatac ggaaaatgat ttttgataaa tttctcttcc 3514261 gcatacgcaa tcgcttggtc gccaatgttt gtgtagctag gggaaccaaa caaaaatact 3514321 tttcgtttat catttaacag agcttccggc tccacatttg gcgcaatgcc ttttactagt 3514381 tttttgcctt tgatttcttg tacagtcata tctgcgtcct ccttctggga tgaattcctc 3514441 attgtgtgtt aactgtctct acccaaaaag aaggatggct atgcattggc atgtgcatcg 3514501 gctatatcag aaacatcgtt ttcgccaatt tgatagacgc tgcaatgtcc cgcgccgttc 3514561 tttccatata ttccgcggca tgttcaaacg cgtcttctag tggcacggct ccggggacga 3514621 tgctgaaaag cgcatcgatt ccgtgttgat agacggcatt actgtctcgg gaaattgatc 3514681 ccgcaatgcc gataacgggc acatcgtatg atttagcggc cttggccacc ccgatcggtg 3514741 tttttccatg aaccgtttgg ctgtcgattc gtccctcgcc ggtaatcaca aggtctgcat 3514801 cctgaacgat actttcaaaa tcaaccgctt caaggacaat atcaatgcct cttttcaggt 3514861 cagcctgaag ataagttagc aggctccatc caagaccgcc cgctgcaccg gcgccctctg 3514921 tatctcggaa ggttgatccg agcgcttttt ctgccatatc agcgaaatgg cttacgttct 3514981 ggtctagtac atccaacatg tcggccgtcg cgcctttttg cggcccgaaa acagccgtag 3515041 caccctttgg tcctgttaac ggattgtcca cgtcacaggc aacttccagt ttgacattcc 3515101 gcaatctgga atcaagcccg ctcacatcta ttgatgcaag ctgagataac gcgccgcccc 3515161 ctgggccaat ctcgctgcct gagttatcaa gaagccttcc gcccaatgcc tgaatcatcc 3515221 cggctccccc gtcgttcgtg gcgcttccgc cgattccgat gatcaatcgc tccgctcccg 3515281 catcaagagc tgctccgatt aattctcccg ttccccttgt tgtagtgatg agcggatttc 3515341 gcttatctac aggcaccaga tgcagccctg aagcagcagc catttcaatc acagctgttc 3515401 tcccatctcc catcatgcca aagaaagctc tcaccggttc ccccagcggc cctgtgacaa 3515461 cttgctctat gatccttcca ttggtcgcat cgaccagaga ttgaacggtt ccctcgccgc 3515521 catccgccac cggcaatttt ctgtaatcag cacccggaaa gaccgatttg aaacctcttt 3515581 ctatcgcttc ggctgcctcc agagctgata agctttcctt aaaagaatca ggtgcaatga 3515641 tgattttcat ccaaatcgcc tctttcaaaa catgattcac ttaacctatt gatctccaat 3515701 gtaccataat tgatctggaa atacatacca tgcaatatgg taaaaattta aataaaaatt 3515761 agaaatgaaa gtgtttgcat aaaagaaata ttcacgttat catacttgta tacaagtata 3515821 ctccttgagt gaggaaggtg agtgtatgct agactccaaa gacctgttgt atcccgcaaa 3515881 atggctctca aaagcgtcaa ccggagttcg tgtcgcatac gagctgagaa tgcggatcgt 3515941 ttcaggtctg attgaaagcg gtaccatttt atcagaaaat acaatcgccg ccgagttttc 3516001 agtaagccgt tcgccggttc gcgaagcgct aaaaatactc gcatccgaaa aaatcatccg 3516061 cttagaacga atgggagcgg tcgtaattgg tttaactgag aagaaaatcg cggaaattta 3516121 tgatgtgcgg ttactattag aaacatttgt ctttgaacgg cttgtcaaaa tagacattga 3516181 gcctttagtt aaggatctca gcaaaattct tgaaatgatg aaagtctcaa tcaaatatga 3516241 ggatgctgac gaattttcat ttcaagatgt gctgttccat gaaacgatta tccgagcgat 3516301 tgatcattca tacattcaga tgatctggaa caatctaaaa cccgtcatgg aaagctttat 3516361 tcttttatcg atgcgggtac ggttaaagga aaagtatgaa gacttcacaa ggattttaga 3516421 taaccacgag ctttatattc aagccatcaa aacaaaggat agggcgctga tgattcagtc 3516481 tcttcaccaa aactttgatg atgtgcagga taaggtagaa gacctatggc tctcacaaca 3516541 aatgctggca aaaggagctg aatacaacaa tgactagtta tatgttagga atcgatatcg 3516601 gcacgacaag cacaaaagct gtgctgttca gtgaaaacgg agatgtggta cagaaagaaa 3516661 gcatcggcta cccgctctat acaccggaca tctcaacagc tgaacaaaat ccggaagaga 3516721 tttttcaggc agtcatccat acaacagcga gaattacaaa acagcatccc gaaaaacgga 3516781 tctctttcat ttcgttcagc agcgccatgc acagcgtcat tgcaatcgac gaaaatgaca 3516841 agccgctgac gccatgcatt acatgggccg acaacagaag tgaaggctgg gcgcataaga 3516901 tcaaagagga attgaacgga catgaggtgt acaaacggac gggaacaccg attcatccga 3516961 tggcaccgtt aagtaaaatt gcctggatca cgaatgaaag aaaagaaatc gcttccaagg 3517021 caaaaaaata tatcggcatc aaagaataca tttttaaaca gctgttcaat gagtatgtca 3517081 tcgattactc attggcatca gcgacaggca tgatgaacct gaagggcttg gattgggacg 3517141 aagaggcact gcgcatcgca ggcatcacgc cggatcactt atccaaactc gtgccgacaa 3517201 ccgagatctt tcagcactgc agcccggaaa tagcgatcca aatgggaatc gatccggaaa 3517261 cgccttttgt catcggcgcc agcgacggcg tgctgtccaa cctcggcgtc aacgccatta 3517321 aaaagggtga aatcgccgtc accatcggta caagcggtgc cattcggacg attattgaca 3517381 agccgcaaac cgatgaaaaa gggagaattt tttgctatgc cttgacggac aagcattggg 3517441 ttattggggg acctgtgaac aatgggggca tcgtccttcg ctggatcaga gacgagtttg 3517501 cctcctccga aatcgaaaca gcgacacggc tgggcattga tccatatgac gtgctgacga 3517561 aaattgccca acgcgtcaga cccggttctg acggtctgct gttccaccca tatctcgccg 3517621 gagaacgcgc tccgttgtgg aatccggatg tacgcggctc atttttcggc ttgaccatgt 3517681 cgcataagaa agagcatatg atacgcgcgg cattggaagg cgtcatttac aacctgtaca 3517741 cggtgttctt ggcgttaact gaatgcatgg atggcccggt aacccgcatc caagcgacag 3517801 ggggttttgc aaggtcggag gtttggcgcc aaatgatgtc ggatatcttc gaatcagagg 3517861 ttgtcgttcc ggaaagctac gaaagctcat gtctcggcgc ctgcatttta ggcctgtatg 3517921 caacaggaaa aatcgattct ttcgacgccg tgtccgatat gatcggcagc acatacagac 3517981 atacgccgat cgaagactca gccaaggaat acagaacatt aatgccgatt ttcatcaatc 3518041 tatcaagatt attagaaaat caatatacac aaattgcaga ttatcagagg ggcttaatca 3518101 cacacaaata gtacatgaca tgaaggggag ggcattacca tgccgttaat catcgttgca 3518161 cttgggatct tagcattact atttctgatt atgggcttaa aattaaacac atttatttcc 3518221 ctgctggtcg tatcgttcgg cgtggcactg gcactcggga tgccgttcga taaagttgtc 3518281 agctccatcg aagcaggaat aggggggact cttggccaca tcgcgctcat cttcggactc 3518341 ggtgcgatgc tgggcaaact gatcgcggat tcaggaggcg cacagcgcat tgcgatgacg 3518401 ctcgtcaaca aattcggtga gaaaaatatt caatgggccg ttgtcattgc ctcattcatt 3518461 attgggattg cgttattttt tgaagtagga ctggttctat taattccgat tgtctttgcg 3518521 atttcaagag aattgaagat ttctatttta tttctcggaa tcccgatggt cgcggcacta 3518581 tccgtcacac acggtttcct gccgccgcac ccgggaccta cggcgatcgc cggtgagtat 3518641 ggcgcaaaca ttggagaagt gctgctgtac ggctttatcg ttgctgttcc gacagtgctc 3518701 attgcagggc cgttatttac aaagttcgcg aaaaaaatcg ttcctgcatc atttgcgaaa 3518761 aacggcaata ttgcatcact cggcacacaa aaaacattta accttgaaga aacacccggc 3518821 tttggaatca gtgtctttac tgcaatgctc ccgattatca tcatgtcggt cgcgaccatt 3518881 atcgacctgc ttcaagaaac aatcgggttt gcagataacg gagttttagc ttttatcaga 3518941 ttgattggaa acgcatcgac tgctatgatt atttcgttat tggtcgcagt ctatacaatg 3519001 ggcatcaagc gcaacattcc agtcaaaacc gtgatggatt cttgttcaac tgccatttca 3519061 caaatcggca tgatgctttt gatcatcgga ggaggcggcg ccttcaaaca agtgctgatc 3519121 aacggcggtg tcggcgatta cgtagcagac ttattcaaag gaacggcatt atcgccaatc 3519181 attctggcat ggctcatcgc agcgatcctg cgcatttctc taggatcggc gactgttgcc 3519241 gcactaagca caacaggtct ggtcattccg ttattgggcc attctgatgt taacctggcg 3519301 ttagtcgtac tcgcaacagg agccggaagt gtcatcgctt cacacgtcaa tgacgccggc 3519361 ttctggatgt tcaaggaata cttcggatta agcatgaaag aaacattcgc cacatggaca 3519421 ttgctggaaa ccattatttc cgttgctgga ctgggattca ttttattgtt aagtttagtt 3519481 gtatgaaatt aagaaggagc tgtaacacat gttcaattcg attggtgtca taggcttagg 3519541 cgtaatggga agcaacatcg ccttaaacat ggcaaataaa ggcgaaaacg tcgctgtcta 3519601 taattacacc agagatttaa cggaccagct tatccaaaag ctggatggac aatctctcag 3519661 cccgtattac gagcttgagg actttgttca atcgttagaa aaaccaagaa aaatcttttt 3519721 gatggtcaca gcgggaaaac ccgtagattc cgtcatccaa tcattaaagc ctttgcttga 3519781 agaaggcgac gtcatcatgg acggaggaaa ctcccactat gaagacacag aaagaagata 3519841 tgacgagctg aaggaaaaag ggatcggcta cctgggagtc ggcatttccg gcggtgaagt 3519901 cggtgcgtta acagggcctt ccatcatgcc gggcggagat cgcgacgtct atgagaaagc 3519961 cgctcctatc ctgacgaaaa tcgcagccca agtcggagat gacccttgct gtgtctatat 3520021 cggaccaaaa ggggcagggc actttacaaa aatggtgcac aacggcattg aatatgccga 3520081 catgcagctg attgcagaag cttatacgtt tctaagagaa acgcttcgtc tgccgctaga 3520141 tgaaattgca tctatttttg aaacatggaa tcaaggtgag ctgaaaagct atttaataga 3520201 gattacagct gagattttac gcaaaaaaga cgaaaaaaca ggacagcctc tgatcgatgt 3520261 catccttgat aaaaccggcc aaaaaggcac cggaaaatgg acgagcatgc aggcgattga 3520321 taacggcatc ccgtccacga tcatcacaga gtccttgttc gcccgctact tgtcatcttt 3520381 aaaagaagaa cggatggcag ctcaagatgt attagcaggc ccggaagccg aagaaaaaca 3520441 cttggataaa gacacttgga ttgaatacgt cagacaggct ctttacatgg ggaaagtatg 3520501 cgcctatgca caaggctttg cccaatataa gatgtcatct gagctttacg gctggaatct 3520561 gccgctcaaa gacatcgcct tgattttccg aggcggctgc atcatccgcg ctgatttcct 3520621 aaacgtgatc agcgaagcat tcagtgagca gccaaatctg gctaacctgc tgatcgcgcc 3520681 ttatttcaca gataagctcc atgcctatca aacaggcctg cgaaaagtcg tttgcgaggg 3520741 tatcagcacc ggaatctctt tcccatgctt aactaccgcg ctctcttatt acgacggcta 3520801 ccgcacaggg cgttccaatg cgaacctctt gcaggcacag cgcgattact ttggcgctca 3520861 cacgtacgaa cggactgata tggacggcgt cttccatacg aattggtctg aataacctgt 3520921 attaaaaaca cggtcagttt caactgaacc gtgttttttt cttctatccc aaacaacaga 3520981 agacataagt tatgttttaa atatcataaa cagtgataca ataatagcta gaaacaatcc 3521041 ccaagatcat catgtgacag cagattgctg ttccgttcta ttctgctttt ggccattgtc 3521101 ctttgccctt gaccatggtg tcataaaatg ttcaaatgcc aaaacggcct ggcattctga 3521161 tttacaaaag tccctgaaaa ccttatctaa ttgagaatca gcctctcatt tattataaaa 3521221 gaaatgccta aatcctacct gtcacacctt tattaagatg aaaaaaagta ggttatggct 3521281 tgacaaaaaa tatatattaa ttaataattc atatataatt agaattatta ttgaaagcga 3521341 ttatgctttc taatacattt ttaggaggaa tatacattat gtctttaatc ggtaaagaag 3521401 tacttccatt cgaagcaaaa gcattcaaaa acggtgaatt catcgatgta acaaacgaag 3521461 atttgaaagg ccaatggagc gtattctgct tctacccagc agatttctct ttcgtatgcc 3521521 caactgagct tgaagatctt caagaacaat atgctgcact taaagaatta ggtgttgaag 3521581 tatactctgt ttctacagat actcacttcg tacacaaagg ctggcatgac agctctgaaa 3521641 aaatcagcaa aatcacttac gcaatgatcg gtgacccatc tcaaacgatc tctcgcaact 3521701 tcgatgttct tgacgaagaa actggccttg ctgaccgcgg aacattcatc atcgatccag 3521761 acggcgttat ccaaactgtt gaaatcaatg caggcggtat cggccgtgac gcaagcaacc 3521821 ttgtaaacaa agtaaaagca gctcaatacg ttcgtcaaaa cccaggtgaa gtttgcccgg 3521881 ctaaatggga agaaggcggc gaaactctta cacctagcct tgatctagta ggtaaaatct 3521941 aaggagtgca ttcaattggt acttgatgca aatatcaaag cacaattaaa tcaatatatg 3522001 cagctaattg agaatgacat tgttctcaaa gttagcgcag gcgaagatga cacttctaag 3522061 gacatgctgg ctctcgttga tgagctggct tccatgtcat cgaaaatttc agttgaaaaa 3522121 gctgaattaa acagaacgcc gagcttcagt gtcaatcgtg tcggagaaga cactggcgtg 3522181 actttcgccg gtatccctct gggccacgaa ttcacatcat tagtgttggc gttgctccaa 3522241 gtgagcggca gaccgcctaa ggtagaccaa aaagtcattg atcaggtgaa gaagatcagt 3522301 ggtgaatacc acttcgaatc ttatatcagc ctgacatgcc acaactgtcc tgatgttgta 3522361 caagctttaa acatgatgag cgtgctgaac ccgaacatta cgcacacgat gattgacggt 3522421 gcagcataca aagcagaagt tgaaagcaaa aacatcatgg cagtgccgac cgtttacctg 3522481 aatggcgaat ccttcggaag cggccgtatg acgcttgaag aaattcttgc gaaaatgggc 3522541 agcggcacag atgcatctga gtttgctgac aaagagccgt ttgacgttct tgtggtcgga 3522601 ggcggacctg ctggtgcaag tgcagcgatc tacactgcac gtaaaggcat ccgaactggt 3522661 gttgtcgctg agcgcttcgg cggacaggtt ctcgacacca tgagcatcga aaacttcatc 3522721 agcgtcaaag cgacggaagg accgaagcta gcggcaagtc ttgaagagca tgtgaaggaa 3522781 tatgatattg atgtcatgaa ccttcagcgt gcgaaacgcc ttgagaagaa agatctgttc 3522841 gaacttgaac tcgaaaacgg cgctgtcctg aaaagtaaaa cagtgatcct ttcaacaggt 3522901 gcacgctggc gcaatgtcaa cgtccccggt gaacaagagt tcaaaaacaa aggtgtcgca 3522961 tactgcccgc actgtgatgg gccattgttt gaaggcaaag acgttgcggt aatcggcggc 3523021 ggaaactctg gtatcgaagc agcgattgat cttgcaggta ttgtcaatca cgttactgta 3523081 ctagaattcg cgccggaact gaaagcagac gaagtcctgc aaaaacgtct ctacagcctg 3523141 cctaacgtta ctgtcgtgaa aaacgcacaa acaaaagaaa tcacaggtga tcagagtgtt 3523201 aacggcatca catatgtaga ccgcgaaaca ggcgaagaaa aacacgttga acttcaaggt 3523261 gtattcgtcc aaatcggtct cgtgccaaac acagaatggt tagaaggaac ggttgaacgc 3523321 aaccgcatgg gcgaaattat tgtcgacaaa cacggcgcaa caagcgtacc aggcttattt 3523381 gctgccggcg actgcacaga cagtgcgtac aaccaaatta ttatttctat gggatcaggt 3523441 gcaactgccg ccctcggcgc gtttgattac ctaatccgta actaatataa gaaatccgct 3523501 atattgccag attggcagga tagcggattt ttctttttct acagaaaaaa accgaaccag 3523561 gcactacggt aaaagtgctc gattcgagcg cttcttatag ttcctcacca ttcgtttgaa 3523621 tgacattttt ataccactca aaggagtctt tcttatatcg tttcatggat ccgtttcctt 3523681 cattgtcacg atcaacatag atcatgccgt agcgtttttt catttcgcca gttgtgaagg 3523741 agacaatatc aataatgccc cacggcgtgt agccaattaa atcaacacca tcgtacgtga 3523801 ccgctttttt caatgcttca atatgcgatt ttaaatattg aatgcgttcc ggatcatgaa 3523861 ccttgccgtc ctcctccagc gtatccactg cgccaaagcc attttcaacg atgaataacg 3523921 ggatttggta tcggtcataa aaacgattta acgtatatct caacccggtt ggatcaatcg 3523981 cccatcccca gtcactcgaa gtgatgtacg gattttcgac accattcggc aagccgccat 3524041 ttacaatatc gccagtgtta tcatttttca catcgctttt cacagttgtt gacatgtaat 3524101 agctgaagcc taagtaatcg acggttccgt ttcttaaaat ctcatcatcg ccgtcttcga 3524161 atgtgatgtt gtagccttcg cgttcaaatt ccttcaacgc gtagcttgga taataaccgc 3524221 gaacctgcac atcagggaag aaatagcgct gcctcatttc ttcttcagcc agcatcacat 3524281 cttcaggatt ggaggagaaa ggataaatcg gcacgtgtga taccatggcc ccaatctgga 3524341 actctggatt gatgtctttt ccttttgcca ctgctaaggc gctcgccact aattcatggt 3524401 gcgccgtttg atacatgact tccttggcgt tttcgttttc gccaaccaca acacctgaat 3524461 tcgtccatag gaacagcgga ttgttcacat ccatttggtt gttaatctcg ttaaatgtca 3524521 tccagtactt cactttatct ttgtaacggg taaagcaagc ctctgcgaag ttgacgaaga 3524581 agtccacgac tttccggttt ctgaagccgc catattctct tgccaggtgc agcggcattt 3524641 caaagtgaga cagggtaatg accggctcga tcccatgctt cagcaattca tcaaacacat 3524701 catcataaaa ctgcaaacca gcttcgttcg gttcagcctc atcgcctttc ggaaaaatcc 3524761 ggctccagcc gatggacgtc cgcagacatt ttaatcccat ttccgcaaac aaagcgatat 3524821 cttccttgta tctgtgatag aaatcaatgg cttcatggtt tggataaaat tcgttttctt 3524881 caatcgtgtc agtgattttt ctcggcacgc cgtgcgcacc cgctgtcatc acatcgacga 3524941 cactcggccc tttaccgcct tgattccatc cgccttcaaa ttggtgggca gctaaagcac 3525001 cgccccataa aaaatccttt ggcatgtttc ccatgtttaa ttcctcctca gcttacgact 3525061 gtaaatattt tttgatgtaa tgcactttcc tcaatgtctt caatgaaagc tttatcaaac 3525121 tcaacaagca cttcgccttt tttgacggta tcgccttctt ttaccttcaa ggaaaaaggc 3525181 gtgccgtcaa atgtcaccgt atccagcccg atgtgcgcaa gcaattcgac gccggacgct 3525241 gaacgcaggc caatcgcatg ctttgtaggc gtaaccatga caaccgtaat gacgccggga 3525301 tggtagcatc gatttcacga tatccttcgc tttaggggta gaccgcttca gcaccaatcg 3525361 aagtctggta gcgcagcgag aagccccaat cacattctct tccccgccta cggcctctaa 3525421 aatgtctttt gctagtctcg tataatctct cactttcccc gacatttcac ccaccccttc 3525481 gttttggtta cgctttcatt ataattgtaa cggtataatt tatcaattcc gaaacaaaat 3525541 atttacgcac taactatcat tgtaagcggt ttatgctata attttgacaa gtgaaactaa 3525601 acgaataaat gaggaatgcg tatgttaaaa taccagcaaa tcgcaacgga aattgaaaca 3525661 tatatagaag aacaccagct tcagcaggga gacaaactgc cagtcctaga aaccctcatg 3525721 gcccagtttg aagtcagcaa aagcaccatc acaaagtccc tcgagctatt agagcaaaaa 3525781 ggcgcgatct ttcaggtcag aggaagcggc attttcgtca gaaaacataa acgaaaaggc 3525841 tatatcagcc ttctgtcgaa tcagggattt aaaaaagatc tcgaggattt caacgtcacc 3525901 tcaaaagtca tcgaactgga cgtgagaaag ccaacaccgg aagcggcgga aaacctgaac 3525961 atcggaatgg acgaggacat ctactatgtc aaaagggtcc gctacatcaa cggccagacc 3526021 ctttgctacg aagaatccta ttacaccaaa tccatcgtga cgtatttaaa caacgaaatc 3526081 gtctcccact ccatcttcca ttacatccgg gaaggactgg ggttgaagat tggtttttct 3526141 gatttgtttc tgcacgtggg ccagcttaat gaggaagaag cggaatattt gggattagag 3526201 gctggactgc cgaagctgta tatagaaagt atttttcacc tgacaaatgg gcagccgttt 3526261 gattactcga agatttcgta taattatgag cagtcgcagt ttgtggtaca ggctaatagt 3526321 tttttattat agggctcttc actacggtag gtggtcgaca tgtacaaaat tatcattcct 3526381 gccatactag ccatctttgc gctctggata ctcttacaga tttcactaga gatgagcatc 3526441 gttaagaatc caatgaacta ctttatcgta ttcattatct ttttcctctt tgtaaagatg 3526501 gtgaaagaaa aacaataata gtttgggcga tgcaaacaga aaaacatcct tcccttaaca 3526561 aactcagcca gtcacatgca ttaatcttga tgttaatgat atataggtgc acataaaaag 3526621 ctacttcatt gtgaagtagc tccctttatt aaaggcccat tttgatccat ctagttttag 3526681 aaaagcgaag gacaatcgca tttatgataa taattgaaac taaatacaaa ataataaata 3526741 aaacatcatt actcccaagt gtcatgttat cagattgcag cactctttct attcgggggt 3526801 acatagtgtt acctgcctca aaaggagcaa tgaaaccaaa cgttttattg cttatagcta 3526861 ctaagataac agaagtcatc caataaacga tactgacacc tatactaatt aatatattag 3526921 gacataacac gcttatagtt ccgataatta gaatatactg cagtataact gcagaaaata 3526981 aaaaaagtaa taatgcaaaa tgcgaaaaat catggtacat caacgatatg attagcaggc 3527041 ctagcgttat aaatgcaaaa cattctaaaa ataaaacagc tatcttttta taaaagaaag 3527101 tatagatgtt ctctccaatt aacttgtaaa agagaatatt tttgtttgaa tactctctat 3527161 taataaagaa agctataaca aatgaaaata acatcaaacc aaactgggtc gcaacagtat 3527221 aggagctaaa gaaaaacatt tcaggtgtaa cattactgac tttatcgatt ccaacaagta 3527281 aaaaataacc cagcaaaaat aaaaatacaa acattgctcc taaaataatg ataactttgt 3527341 tgctaatact ctttttaaac tctaatttca tctcaagccc ccactgtttt attactcatt 3527401 tatatacact tcaattaatt tatccactga atgatattgt tgaatttctt ggtgattaaa 3527461 tatataataa tccccttcta tcgcctttaa atcagacaaa tcatgtgtaa tgttgatgat 3527521 aatcttctcg gggttctcct gaatatactt gtttaagaag ccatgaatct ctataaccgt 3527581 ttttttgtct aatgaattcg ttatttcatc taaaacaata atatttttat cctctaataa 3527641 gaaactgagc aattttaatt tttgcttttg tccatcactc aaatttttga tcagaacttt 3527701 tccatcaata ttatccagat taagtaaata tgcgatttta tctatcattt ttgcatcaaa 3527761 ttttttactc aaaaagtgta ataaaaagtc cttagaaaca tcattaggta tattcgacga 3527821 gctggatatt aaagaaacat tttgacgaat atctctgccg attcttttgc tattattcaa 3527881 caaaaagtct ttagcaagct gtgatttacc gactccattt tttccgacaa cgtgattaat 3527941 tttcccgctc gaaaaatgca agtcggtgtc ctgaagtaac gttttgcctt tcacttttaa 3528001 agtgtaattc gctatattca tatacatact cctaggaaat atttgcataa taataaaatg 3528061 ttctgccttg tgatttgtta ctaatgtcta agcttttgag gtacctcttt cgtttccgat 3528121 ccggaagcga aagaaatgtt tttagatggc taatttggag atcttttact ctagtttaca 3528181 atatataata tccaatgtac aactgaattc actgcaaggc caatccctat aatttgaatc 3528241 gtaagaacta accaatgatt tgtcttaaaa cggctatatt catctaagct cagaaaagct 3528301 aaaagaattt tgtaaccatc agaattcaat attgggatta agttccacaa taaagtagac 3528361 gagaaaagca taaatgccat agttaatgct tcactggaaa atgtaaattg atttattaat 3528421 tctaatgtat ttattaaaag ataattgata aacaagccaa ataaatgaac gattatcttt 3528481 tcatttcttg atagcatgta ggtttcattc aattggacat aaaaagcagg aaatacataa 3528541 aaattcagtt tgaatcccac tttatcaaag tttttcccga aaaattttaa ggaataaata 3528601 tgtcccagtt catgaagcac tatattcatt ataaaataaa taactataat tatccacatt 3528661 ttccagccgt aaaatactga ggacaatcca ttttgcaatt ttattaaatg aatataattt 3528721 aatatgaaca tgagagccgt aaaggataag aacagataaa aaaactttgg tgatactttc 3528781 tctttataca ttttaaaacg taataattgt ttatctgaca gagaatttaa actattttta 3528841 tagtattctc cgcttttttt gtcttttata aatacgttgt tttgcacaag cacttcatat 3528901 ttttcatctt catactttaa aattttcatt atagtatttt tccatataag gatagaagta 3528961 gtttattttt tctgcagagt tgaataagga accacaaact ccacaaatag aggaaaattc 3529021 ataaggaatg tcaaattcct ctattttgtt attttctttt aaaatattca aaaaccattt 3529081 gaatccttct tttctaagaa taaataatag caaattggaa tttaactttt ccacggttct 3529141 ttcgaaactt tggttatatt cttcccttag ggttattttc gtttcaaaaa tagcagggga 3529201 acaacatgga taaatttctc catcatgatg atatacaatg tcatatccgg gacaatgtaa 3529261 ggaatcttca tcttcaagac tgtaaaattt atgtatgttt tcttgcttaa ttctagtttt 3529321 agcagcgcca actgatatca ttggaaattt tgttatcttt acacctaaga ttgaatcccc 3529381 caattcctct aaaatgtggt tggacatttt gtctttggta actgccatat taagagaaat 3529441 atcgatatca gggtatttcc tgctatgttc taatatgttt ttaatactgg aagacttgac 3529501 aaatggagca tggtactcat cataacttat agtcagtgct atcacattta aagaattcat 3529561 atcatgaaag tactcctgga cctttttctt gctcaaaccc caaaatccat tagagatcaa 3529621 cgttatttgt ttttcatatg gtttaatgat ttccattagt tcttttaaaa atttataatc 3529681 taaaaaaact tccccacctg taaaagaaat cacttgaatg gttttgtttt ttgcaaattc 3529741 agttactaac tctcttatgt attctttttc catcctggtt gttgaagttg gtgaactaga 3529801 aaaacaacaa tggtcacagg atgcattaca ccttgaatct aaattgattg atactgtttt 3529861 attatacatg aaatatcccc caacaaatgg taaaggagag ttagactctc ctttgtaccc 3529921 ctctaattaa tgaccacttc caagaatcca gcgattttct tttgatttta caaaatacca 3529981 aagatcattc acttttgcta acttttgtga ttcatctaat agacccttaa attctaagtt 3530041 tttcacagtc tcattgttag tgatttcctt tttcatatta tccctcctcc ttttctaata 3530101 taaaccaatt attctatatc attcaataca tgtcaatata ttgtacctaa aaaatctgaa 3530161 aaatgtcact attcttggta tataaagcct atagtcctct agcccctcta agctataccg 3530221 aatgaaaggc catagtttga tttaaagctt cgtaatgaaa agtaaaacat caatattgac 3530281 tacactagtt aagggatata cagattttaa gtggaagaaa tgaggcaaac aatcttaccc 3530341 taaaccaacc tgtactgaaa agctgtttta agctcttgct taccccattt ggcacctctt 3530401 tctctcgttt taattgtctc taaaagcagt tatgcggtac tatcatataa aggtccaatg 3530461 tttaaaaata atgtcatact tttaaattca ccttatcatg cacatgctca taaagagggg 3530521 tttattctaa aaaggggatg gacggttttg gaaagcaagt acctagatct actcgcacaa 3530581 aaatacgatt gtgaagaaaa agtggtaaca gaaatcatca atttgaaagc gatattgaac 3530641 ctgccaaaag gcaccgagca ttttgtcagt gatctgcacg gagagtatca ggcattccag 3530701 cacgtgttgc gcaatggttc aggacgagtc aaagagaaga tacgcgacat cttcagcggt 3530761 gtcatttacg atagagaaat tgatgaatta gcagcattgg tctattatcc ggaagacaaa 3530821 ctgaaattaa tcaaacatga ctttgatgcg aaagaagcgt taaacgagtg gtataaagaa 3530881 acgattcatc gaatgattaa gctcgtttca tattgctcct ctaagtatac ccgctccaaa 3530941 ttacgcaaag cactgcctgc ccaatttgct tatattacgg aggagctgtt atacaaaaca 3531001 gaacaagctg gcaacaagga gcaatattac tccgaaatca ttgatcagat cattgaactt 3531061 ggccaagccg ataagctgat caccggcctt gcttacagcg ttcagcgatt ggtggtcgac 3531121 catctgcatg tggtcggcga tatttatgac cgcggcccgc agccggatag aattatggaa 3531181 gaactgatca actatcattc tgtcgatatt cagtggggaa atcacgatgt cctttggatc 3531241 ggcgcctatt ccggttccaa agtgtgcctg gccaatatta tccgcatctg tgcccgctac 3531301 gacaacctgg atattattga ggacgtgtac ggcatcaacc tgagaccgct gctgaacctg 3531361 gccgaaaaat attatgatga taatccagcg ttccgtccaa aagcagacga aaacaggcca 3531421 gaggatgaga ttaagcaaat cacaaaaatc catcaagcga ttgccatgat ccaattcaag 3531481 cttgagagcc cgattatcaa gagacggccg aactttaata tggaagagcg gctgttatta 3531541 gagaaaatag actatgacaa aaatgaaatc acgctgaacg gaaaaacata tcaactggaa 3531601 aacacctgct ttgcgacgat taatccggag cagccagatc agctattaga agaagaagca 3531661 gaagtcatag acaagctgct attctctgtc cagcattccg aaaagctggg ccgccatatg 3531721 aattttatga tgaaaaaagg cagcctttat ttaaaatata acggcaacct gttgattcac 3531781 ggctgtattc cagttgatga aaacggcaat atggaaacga tgatgattga ggataaaccg 3531841 tatgcgggcc gtgagctgct cgatgtattt gaacgattct tgcgggaagc ctttgcccac 3531901 ccggaagaaa ccgatgacct ggcgacagat atggcttggt atttatggac aggcgaatac 3531961 tcctccctct tcggaaaacg cgccatgacg acatttgagc gctatttcat caaagagaag 3532021 gaaacgcata aagagaagaa aaacccgtat tattatttac gagaagacga ggcaacctgc 3532081 cgaaacatcc tggcagaatt cggcctcaat ccagatcacg gccatatcat caacggccat 3532141 acacctgtaa aagaaatcga aggagaagac ccaatcaaag caaacggaaa aatgatcgtc 3532201 atcgacggcg gcttctccaa agcctaccaa tccacaacag gcatcgccgg ctacacgctg 3532261 ctatacaact cctacggcat gcagctcgtc gcccataaac acttcaattc caaggcagaa 3532321 gtcctaagca ccggaaccga cgtcttaacg gtcaaacgat tagtggacaa agagcttgag 3532381 cggaagaaag tgaaggaaac gaatgtgggt gaggaattgt tgcaggaagt tgcgatttta 3532441 gagagtttgc gggagtatcg gtatatgaag tgaggggtgt ggggttcagg gatggtgata 3532501 tgctgctccc ctaaaagtag atagatgaat tttagaaaat ctgtttgcct tggggagttt 3532561 tttcatggct ggacaattat actacaagga agaaatacta atacttatag aatgtaattg 3532621 ggtaatgatt cggagaaaga ggttgcgaaa taatatggta ttacactgaa acaattatca 3532681 atggagaaca tgcacgatat agccgttcta tattctccct ctattatggc actcattagt 3532741 agacataacc gtaaaaaaat gcactcaaaa aaagtccatt ctatataact ctcgctaggg 3532801 tggacctttt tcaacattca aagtactaga ttttttctag tgaaagaata agaaaagaca 3532861 taagttctat tttatcactc tgttataggt taagttatta cggtgtttca ttatatactg 3532921 aatttaaaca cccttgacat tatgggaatt tttaaaacag gttaaaagga agttctataa 3532981 gaactcccta gtttaatatt atttggtcaa aatctaaaac caaaaaatct atttttatct 3533041 tcattgtttc tatctaattt tgcaacaatc atacctttcg actctaattc ttgaaggtca 3533101 tctaataata attcattttt atttattgtt acaaaatatt gtccgatcct attctctaac 3533161 agacttgaat tgatatgttt taataatgta ccttttacat gaggatcagg attagaataa 3533221 gatccgtcat gaattaaaat attcaaacta cacttattta tacacctgta taaaaaccaa 3533281 gtaagatcaa atatatttat cttcatatgg agtctaccat gtgaacgttc atccggtata 3533341 gaacaagaaa ttttgatcct tcctgtagtt gattgttttg cgttacttat tctattatca 3533401 tattcaaaat ctaaaaatcc atgttggttg tatgtaacat ccattagatt attaaaaagc 3533461 ttctttaact cactaactat agcgctataa gattgaaact catcataata cattgaatta 3533521 actcttaata tttcatgttg aagttcatta atcttatcaa aaatatggtt ttttttatcg 3533581 tagtcactaa ttctcaatct tacttccgct aactctattt ctttccttct ttgttcttcc 3533641 atcacaatgg aaatatcctc aatgaaattg ttactcttta aaattctggc acttgattcc 3533701 agttgttctg ttaatccttg ctttttgata ttaagttttt ttaaatcggc ttgtatttta 3533761 acaattttat ctttaaaata actccctcta ctttctacca tgaaattata gaactcttgg 3533821 actttattat aattctgttt tacttcctct ggaaaaaaac ctacaatatc ttcatagaat 3533881 ttttctatat tttctaattc tttaatctta gttacttttt tatttaaatc atctatattt 3533941 ctttgatatt gtttacaaat atgttcattt tcaaatattt cattttgtat tttattaagt 3534001 tcacttttaa tttctgagta cctatttgta tcattattat atttattggc agtcttagtt 3534061 tgatagataa ctctattgta atcctctatc tcatttatta attcatcttc cttaactttt 3534121 aaatcgccaa tgttaatatt cattgattca atcaatttta tttcactatt taatttttca 3534181 atcttatccc gaaaaacctt tatgtttttt tctgtatgag ttggtaaagt aaaaagatag 3534241 ttaagtaatt tatattgttt taaccctccc ctattcggta aaactatatc attaaaccct 3534301 gtcttttcgt ctcttataat atactccctt aacgccgcaa aagttatatc ctctttctca 3534361 ccctttaaaa tttccttttc aataaatttt ttatatacac ttatactaac ttttttccat 3534421 tcctccaaat taaaagttaa agaagtatca tgtaatgtat aaccatgttt aggagaatta 3534481 aaagatctag caaggaatac ttgatttcca tcaatttcca cattcaaaac aataaaaacg 3534541 tttttattga gaagaatttc atttgtcgta taaaaatttg atatagtctt ccctagtaaa 3534601 aaggagatgc attcaatcat cgttgactta cctacaccat tagtctcttc atgatcttct 3534661 ctcttttcac caagtattat atttactcct acagcattaa atttatactc tttcaaaatt 3534721 tcttgggaat tgcaaacaaa aagatttttt ataatcataa caatcactaa ctctccgttc 3534781 tgctaatcat attttgatta aaagaaactt tacctaatga atataaaaaa gttaacgata 3534841 aatacagtat ccgttcaata ttcaaattta ttataatacc ttgactctta gcataatcaa 3534901 gaaaaagttg atcaatatgt ttttccttct ctaacagttc ataaagtatc tttgatgagt 3534961 ataaaatatt ttcttccaca gcattatatt tagttaataa aaaatgattc atttctggcc 3535021 tctccgcctt ttcctttttt aaaggagaat tattcactag aggaataaga tcatttccaa 3535081 tttgaatgtt tttaaactca ttttctaata aaacataaga gtatttgaga atattttcag 3535141 ctgtttcaat tttaagatca atcattctta acacttcttt tgttatcatt aaaaatctca 3535201 cattcataaa tgcaccaaca tgttaaaatc ttaatgtatt ttttcgttaa agcctttgaa 3535261 tatggtaaaa ctgaatgaca ttctagataa atctcattaa caatttttac aaatatctca 3535321 tctccattat tatattgatt atgaaactct agatatttgt ctactatcgt ctcagcaatc 3535381 aattcctttt tatcagcact tacatacgaa gtggaatcca ttatatggtt tatcacacca 3535441 aaatactcag aataactatc gaatttccgt ttaaaagttt ccccactttt catatcataa 3535501 aattttttat ctaaaccaat ttgattatca aaattactag taaatgtttt ataactttct 3535561 ctatactcat gaaaatctat aataaagctc ttaaactcat cttcatcaat tttatcatcg 3535621 ttatcttcta tttctttttc aataaggctc tctaatctat taatcttata atttaacttc 3535681 ccttcctgta gtctccttcc tccttggttg ttttttgacc agtatttata ttcggtattc 3535741 caaatgtagt atgttacttc tgtctcgcca ttatctaaat tcacatccac cgaaataaat 3535801 tctggagtag catactcatc ctttataatg gctccactta ctaattctaa gaatggattt 3535861 tcatttgtat ttgcagtaat attaaatgaa gaatcatgta catgtcctgc caaatataga 3535921 tcaataaagt aatcatcaaa atgtgccttt attgattctc tttcggaaga ttcaatacaa 3535981 cctaacgtat ggtgcccaat agctatattt aataccttgc ccttattttt ctctttgttc 3536041 atcttcctta ttgctttata taatttcatc tgtgcagtta ataacgttcc ttcttcacct 3536101 tttttatctg ataacagaca tgtatttatt gataaaacat tatacttctc cgattgatac 3536161 aaaaaatgca aatcttcttc cggatattta acacccataa aatcttcata aaaatcgaaa 3536221 aatttccttt gaccttccac taatatattt gtagcttttt gatctagttt atccaacatt 3536281 tctgaggggt taggagattt cataatacta tcaatcaaaa gtgtcctcgt catgtctcta 3536341 gatatatcgt gatttcctgg cactaagtgt acgttattct tacttaatcc catactttta 3536401 ataattccat taagatattc tttaacatct tcgttataca catcaccttt gtgtgctata 3536461 tctccagtta ataataaaaa atcaaaatct gactctcttc ttaaaacttc tataaaatct 3536521 aataatttat ctctcattac aatagtgtca taattttgaa actgaaaatg caaatcagaa 3536581 atttgtaaaa aacgtacctt caatacaaac atcctctcat aagtatattt atcccctata 3536641 tatttctaga aaacttttta ttctatatca tctttactct ttaatatatt aagactcttt 3536701 ccacaccatc aaataaatta taacctaaac ataactcttt actcatttta gtattgtatt 3536761 taagtcaaac attgcattgg ttgctgaaat attatattca ttgaattatt ccattaaata 3536821 gcttttagtt gaactttagt ctttctgtaa tggtggagat gctcttactt atgataaggc 3536881 tccccacgat taatccgaaa agcccgataa atctgctcca ctaaaataag ccgcatcaac 3536941 tgatgaggaa atgtcatctt cgagaacgat agcttctcgt ccgctcgctt catcaccgtg 3537001 tcactcaatc cgagtgatcc gccgatgacg aaggtgactt tgctttttcc ataagtagcc 3537061 agcttatcta ttgtatcggc tagttcttcg gatgttttca tttttccttc gatggcgagg 3537121 gcgatgacgt gggcgtcggg gctgattttg gataggatgc ggtcgccttc tttgtctttt 3537181 atgattttca tgtcctggtc gcttaggttt tccggcgctt tttcgtccgg gagttcgatg 3537241 atgtcgattt ttgcgtaggc cgaaagtcgt ttggtgtatt cttcaatgcc ttgcttgagg 3537301 tatttttctt ttagttttcc gattgtcaca atattgatat tcacaggtca tccccacttt 3537361 aaaaacaagt tattcatata tgttgtccac aattgtggat atcttttctg tattttgtgt 3537421 aagatcattc gttccccact atatatactg cggggtctcc acataattca caggctgtgg 3537481 ataaactgtt agtatgttcg atttttctga tttcgggcgg cagctcgtgg tcgtctatgt 3537541 acatatccag caccgtttcg atgtgttctt cacaagaata atacgcttgt ttcatgttca 3537601 aatcctccga tgttttcttc catttttaca aatgttctct tctcaatata acctatttat 3537661 tcacatgtta gtagtgcttc gggctgagtt ttatccacaa ttcgacaaac aagctgttga 3537721 tgactctatt tcgctcgtgt gttagtttgg atgtaaccga tgtgtgggga ggtctgcatt 3537781 tgcgctttag atgggtttgg ctttttgtga ttatgttgct gcttgctgag tgtcagccat 3537841 cttattgggt gttggagaag gatcgaatcg gtgaaggcag tccagactta gaaatatacg 3537901 ctaattatct ccaaatgcat gatgacgtga aaggatatca agtcttcacc atatcagaag 3537961 gcaaaaaaat ggtcgtcgtg tctctcggaa gcagcgagaa agataagaag cttgaagtgt 3538021 cggacgtcaa attctcatct aaagaaacga ttgtaactgt ggagcgaaaa cctgctccta 3538081 cggcaaatga gaaaaaccct tttattttga ttggactgga caaaattgaa ggggatttaa 3538141 ttgttcaaga cgaaacagga gatcgctttg aagaaacgga ttaccagcaa taaagccggc 3538201 gttctgagaa cgtccggctt tttcttttac ttcaatgtcc catgcgggtc gatgacgaat 3538261 tttttggctg cgcctttgtc gaagtcgctg tagccttttg gcgcgtcgtc cagagaaata 3538321 acggtggcat tgacggcttt tgcgatctgc gctctgccgc tcaggatcgc tttcatcaaa 3538381 ttgcggttgt atgtcatggc gggcgtttgt ccggtgacga aggtgtgggc tttggcccag 3538441 ccgagtccga agcggatttt taatgagcct gttttggcgt ccgcatcctt tgcaccggga 3538501 tcttcggtca cgtataagcc tggaatgcca aggctgcctc cgacctgggt gacgtccatg 3538561 attgagttca gcacggcggc tggcgcttct ccttgattgc cgtgcccaga tgcttcaaag 3538621 ccgacacagt ccactgcagc atcaacggtt ggttcaccta gtatttgttc aatttgctcg 3538681 ccgaggcggt cgtgtttttg cacgttgacc gtttcacagc cgaagcttct ggcctgtgcc 3538741 agcctgtctt cgttcagatc gccgacaatc acggtagagg cgcctaggag ctgagcggag 3538801 tgtgcagctg ccaagccgac aggacccgct ccagcgatat aaacggttga acctgtttgc 3538861 acgcccgctg tataagctcc atggaagccg gtcggaaaaa tgtcggacag catggtcaaa 3538921 tcgagaatct tttctagcgc ctgttcttta tcagggaata ccaaaagctg aaaatcagcg 3538981 tatggcacca tgacatattc agactggccg ccgacccagc cgcccatatc gacgtagccg 3539041 taagccgatc ccggccggtc cggattgaca ttcaggcaca catgcgtttt ctgcgttttg 3539101 cacatcacac agcgtccgca ggcaatattg aaaggaacgg atacgatatc tccttttttg 3539161 ataaattcaa catcacgccc cgtttcaatg acttctcccg taatttcatg cccgagcacc 3539221 aagccttctg gcgccgttgt gcggcctctg accatatgct ggtcgcttcc gcaaatgttg 3539281 gttgtaatga ctttgagaat aaccccatgc tcacattttc gattcacatt cgccttcggg 3539341 acgccgggcc cgtccctcaa gattaactcc ggataaccga tatcctccac cgctacagtc 3539401 cctttgcctt tgtacacaac cgctttgttt cctgtcaacg ccattcctcc cattcatgtg 3539461 tttggactct ccgtccttga acatgacttc ggttcggcat gactctttcc ctttttcacg 3539521 actgtttttt ctgtattctt acaacaacaa atatgccaag aaagcatcca ataatggttc 3539581 cgccgatgtc taagaagtcg actttacatc catttaacaa gaacacagta atggccgaaa 3539641 ccaggcagat cataactgcc agaagaataa cccgatttgt ctgcatgtaa ttcctccttt 3539701 ggattcgttt ctaaaccata cccaaaatcc tctgcaaact tcggttcaac aaaaaaagag 3539761 acttcacacc agtctcttca taaacagaga tcactcaaaa aatttcctga gaaataatgt 3539821 ggcaacactc gttactaacg caattgccgt atacataaca acccaaaata tgaatgagct 3539881 attccccgaa gctaacgtaa ctaacaatat caagctcgtg ataagaacga tgagcggtgc 3539941 cacccaaaat cttttaaata aaaaatgacc cgctatacca aatacacctg cgacgatcgg 3540001 aaaaccaaaa acgataaata aaacggcgat ggctcccata ctaccctcct tgccttaaaa 3540061 cctcttcatc acctcaacat catacagctt caaatgactc ttcggcgtca cgacatcctt 3540121 taccttccca atctcttttt ctttcatttt ctttccggtt ttcaggctgt actgttcaat 3540181 gtaggcaggc ttgtgatacg tgtatgtgaa gaaatagagg ctgctgcctt tttgggtgat 3540241 ttctttgaat tcggctttca ttttgtccgg ggaaagggtg aagacgatgc ttgtttttcc 3540301 tgtcttggca tcgattttgt gtacctttcc gaagccgtca atgaaataca ggttcccgtc 3540361 ataagggaaa aagctgtttt taaagctgaa gggcatggag ctgtatatcg tttgttcgtc 3540421 gtttttgtat tcggcgatat cgtgcagctc tacttcgccg ctttttttgt tgatcttgac 3540481 catttgatag agatcgtggg ctttttggcc gcgaaccata acatacacag cttggtcgtc 3540541 cacggcaagt tgggattcga ctgaggctcc ttcccggtac tgccattccg ttatgctgag 3540601 ataggtaagc ttcttctgat ctgcttgaat ctgaaggagc tgatagcctt ttccgtcatc 3540661 tgtcgggacg agtgcgtaaa tggcgccatc atggaaaccg gaggctcgga tgtagtaggg 3540721 gatgacgtct tttttccact ctccgtccat ttggcggtac agctctgagc ggtatccgtc 3540781 tccctttttg tcgtagccgg agttgtataa ggtgtaaaag ccgtccgtgt tttgcagaaa 3540841 gcccgcgctg tcgcctgtgt gctgataggt tcttttatgg gagcgcaggc cgtttttgat 3540901 cgtataaatc gtgtttttgt cctccagcat cacgctgtca ccgtgaacct ttgctgagcc 3540961 cagctcaagg cccttcatct gaaaggaaga cagcgtcccg tcatggctga taaacagggc 3541021 gtagcttttc ccgccgccaa atgcatcttg atccgcagag gatgagaaat acagcaggac 3541081 ttctttgtca tccaggaaat cgggatttct gagatcctgc tgactcacgg ttttatggct 3541141 tttgagagga gaaatgaaga caaatagtgc gattcctgcg agaatcagca tggcgatggt 3541201 aatcatccac tttttcatag ccttctcctt agtaaatggt cataatggtt gtcgtataag 3541261 aagaactagt gatgtcgcgc ggatacacgc ctaagcctcc gttgctgtct atatcaatcc 3541321 ctgctttcag caaaaaggca gaccatagga gctttgaaca gtttttggcg ccgtcatggc 3541381 cggtatttct gttattgacg aagttaaatg agtatgggtc gccgactttt gataccgccc 3541441 agtcggcagc agctgttttt tgagatgagg atacgctgac ggtttgcaca atggagttgt 3541501 cttccacgtc tctggcatta tacgcgatct gcctgacgcc gtcgctcggg acagattcaa 3541561 caattttgtc agcggcggag tacatgccga catggccgtg attgtagtag gctgtgtagg 3541621 agttcgtgta atagatattg cctttcgcgc ttgtcgggag ttttttcgtg ccggacgagc 3541681 cgcccatgat agacatgccg ctttccttgg cgagccggtc cccctctgct ttatcagccg 3541741 tgatctcctt atagaactgt tttaggataa cgtcctgctt tacgtgctgc tgtttggcaa 3541801 tctggctggc agatttcatg atttcttccg gtgtcgtgcc tggctgcagt gcggcgattt 3541861 cttcagcata atttgtggtc tttacggctt tggcgggagt aacaaacagg ccgccgcaca 3541921 ttgtgagcgc taccaaaaac atcgacactc gtttcttcaa cttcattaca tctcctcttt 3541981 tcttgtgagt gtaggaaagg taatttcctc acccacatta tattaggaaa ataaggaaag 3542041 taactaggtt atttacagaa tttttagaaa tcgtttacag aaaaaggcct ttatcaggcc 3542101 cttttcgtta aagcttcttg ctcatcacta cgtctgtttc ttgaaatccg gtttgctcat 3542161 atagctttcg agccgtctga ttatgggcaa agacatgaag ggacagcttg cggattccca 3542221 tactgcgtgc cgcttgatct aatgccgcca atgcttgctt tgcgtagccc tttccccgat 3542281 acggttcata taacccgaaa tcataaataa acgcttcctg ctgcggatgc tccggttcag 3542341 catgtatcca gagccagcca acgatatcct tttcattcag cttgaggctc cacaaatggt 3542401 gatggggtgt ttcgagccct ctcggaagca gatcagtaaa cacctgctta gacaaaagct 3542461 gggcatcttc aggcagccat gttcccgctt ttaccttttc ttccgcgtaa tgctttgttg 3542521 tgtacgtgag ataagaccga aattcttctg tctgcatagg ggttagcata attgtcatat 3542581 catctctcct tcatatattg actagaggat tttacataaa atagaaagag gtgttactat 3542641 cagaataagc aactgagatt gataagtcac tagagaaagg agtttcacat gaataagatc 3542701 gcacccgcag aaatcgctag catgctcaac gattggtacc ttgccatcaa gaaacatgaa 3542761 gttgaagaat cctcccgttt atttgaagaa gtgaagcctt tattggatga catggaagag 3542821 gatcaggagg tgcttgccta cttctcctta ttggaactgc gccacaaggt tttgcttcac 3542881 gaggcgagag gacagggctt tcagcatgag gagccttctc atatgaatgc tacgtctgac 3542941 atgctgaaat attacttttt tctgtttgaa ggcatgtatg aggcctataa aaataattat 3543001 gacattgcca ttgggctgta taaagatgca gagcagtatc tcgacaacat tcccgatccg 3543061 attgaaaaag ccgaatttca cctgaaggtc ggtaagctct attataagct gggacaaaat 3543121 attgtgtccc tcaatcatac acggcaagca gtcaaaacat tcagagaaga gacagattat 3543181 aaaaagaagc tggcttcagc cctgattacc atgtcaggca attttacaga gatgagccag 3543241 tttgaagaag ctgaggctta tttggacgaa gcaattcgga tcacgagtga attagaggat 3543301 catttttttg aagcccagct tttgcataac ttcggccttc tacatgcgca aagcggcaaa 3543361 tcagaagaag cggtttcgaa attagaggag gctctacaga acgatgagta tgcccgctcc 3543421 gcctattatt atcattctgc ctacttgctg atacgagagc tgtttaagat caaaaagaaa 3543481 gaacaggcct tatcttatta ccaagacgtg aaggaaaaat tgactgctga gccgaataga 3543541 atatgtgagg caaaaataga cattttatat gccatttatg cagaaggggg tcatgcggaa 3543601 acgtttcact tatgcaaaca acatatggat gacttgttgt ccgagaaaga gtatgacagt 3543661 gtaagagaac tttccatttt ggctggcgaa cggtataggg aacttgagct ttacaaagaa 3543721 gctgcccact ttttttatga agcattacag attgaagaac tgattaaacg aacggaggtt 3543781 atataaatga aaagatttct gattggcgca ggcgtcgcag cggtgatttt atcaggttgg 3543841 tttattgcgg accatcaaac ccactcacag gaaatgaaag tcgctgagaa aatgattgga 3543901 taaatgaaaa acccccgcgg gatgcggggg ttcaatttaa cgaaagaatc ctaaaacggt 3543961 ttgtagtttt aggattcttt catcttttca gcgtgattga aaacccttga agtctaggaa 3544021 gaacgagcat tggagcgcag cgaatgtttg gaattcgtga gcaccgaagc gcaggcctga 3544081 caacgaatgc gagggtttgt cgacacgctg aaacccccgc gggtgcgggg gttttcttat 3544141 tacagcagct tcttccctaa cagggattct acgagctcta ctgctgtttt gcccgttttg 3544201 tttttgtgat caaggatcgg gttaacctca acgaattcgg ctgaggtaat gatgcctgcg 3544261 tcatacagca tttccatagc caaatggctc tcccggtagc tgatgccgcc gacgacaggg 3544321 gttccgacac ccggtgcgtc gttcggatca agtccgtcca gatcaaggct cagatggacg 3544381 ccatcacatg ctgataaata atcaagggtt tcttcaatga cctttgtcat gccaagacga 3544441 tcgatttcgt gcattgtgta caccttcatg ccgctttcct taatgtactt gcgctcccct 3544501 tcatcaagtg accgggcgcc aatgatgacg acgttttccg gtttgatttt aggcgcgtag 3544561 ccttcaaggt taaccagtga ctcgtggcca atgcctaggc tgaccgcgag cggcatgccg 3544621 tgaatattgc ccgatggtga agtttcaagt gtattcaaat cgccgtgcgc gtcataccag 3544681 atgacgccga gattatcgta atgcttcgct gtgcctgcaa gcgtgccgat cgcaatactg 3544741 tggtcaccgc ccaggacaag cgggaatttt ttctcttcaa tgactttgtt gaccttttgc 3544801 gcgagttttt catttcccgc caaaacggaa ttcaggtttt tcagttcctc gtcatttttg 3544861 attttttcgc gattgatcgg aatgtcaccg agatcttcaa ccgtataccc catgtctgac 3544921 agcctctcga tcagatgagc gtaccggatg gcactcgggc ccatatccac tccgcgtcgt 3544981 gcttgtccta aatccattgg cattccaata accgaaatcg ttttatccat ctgtgattcc 3545041 acctcaacat ttaagataat gtcctatgcg ggttataaca aagatgactt gcggacaacg 3545101 tttttaaagc tctagctgac gatttgcctg ctggcgtttt ttaatgacga catgataaat 3545161 gatgtagcaa atgatcataa acggtacgcc gcaatacagc gcgatacgct gctccggatc 3545221 aaatgcaaga ctgatgagca cgaccgtatt taacgttagg ccgatcagcg gaagcaccgg 3545281 gtacagcggt gttttaaatt tcaaatcttc tatcttcccg ccctcacgga tatatttgcg 3545341 tctgaacatg atttgggaaa gcgagatcgt aatccagccg acctgcgcgc tcatgcccgc 3545401 caaagataac agtaccatat atacggtttc agcctgcgca aactttgtca gaagtgatag 3545461 gcaggccaca gccatcgtta cgattaacga gtacatcggt acaccgcgct gatttgtttt 3545521 gccaagcgct ttgaaggctt gtccttcatt cgccatcgcg tacagaatac gtgttgatgc 3545581 gtataaacct gagttcgcaa cagataacag tgcgattaaa ataacaaagt tcatgatatc 3545641 agctgcatat gggattccga tttgctcaaa tacggcaaca aatggacttt ccacgacacc 3545701 cgcctgtttc cacggaatca tgccggcaat gacaatgatt gaaagcacaa agaacacaag 3545761 cgttctccat actgtctgtt tgatggaccg cggaatcgtt ttttcagggt cttcactttc 3545821 tccggctgca accccgatca gctcagtccc ctgaaacgca aagttcacag taatcatcgt 3545881 aatcagcatt gcctttatgc cgttcggaaa taacccgtct tcataaaaat gtgtcaaaaa 3545941 cggcgcctgc tctccgccct tcagatcaat caggccaaac atggcagctc cgccgagaat 3546001 aataaataaa aggataatca aaattttaat gcctgagaac cagaattcag attccgcaaa 3546061 ggcttttgtg gtgatcgcat ttaaaataaa catcagtgcc gcaaagacca gacaccagat 3546121 ccacacgtct atatgcggaa accagcgttg catcagctgc cccgctgata aaaattcaat 3546181 ggcgcatgta accgcccagc cgagccagta cagccagccg aacgcaaacc cgaaggccgg 3546241 gctgataaat ttcgtggcat aggtctggaa ggaccccgac acaggaaagg cgactgccag 3546301 ctctcctaag cagagcatgg tcaaaaacat gataaagccg cccactaaat aggacagaac 3546361 cgcgccgagc ggtcccgctt ggttaatggt aaacccggtt ccaaggaaga aaccggttcc 3546421 gatcactccg cccaatgaaa tcatgaacaa atggcgtgat ttcattgtcc gctggagctg 3546481 atttccgtta tcttggtttg tattcacatt ctgcacccct tcagcaactt gtattggatc 3546541 taagctggaa catctgcatg gtgctatccc agtttgctgt ccaaagagtc tctatctatt 3546601 taatataaaa ttcacttctt ctcataaaga tacattatac taaaatactg tagctgagca 3546661 aatagggagt gctgattttt ctgttgtaaa tttatacaaa cgaagtgaat atcccgccat 3546721 ggtgcggatt tatgcgtttc gcagcacgtg cttaattttc tctatcgccc aatccaagtc 3546781 ctctttggaa atgattaatg gcggtgcaaa acgaatgact gtatcatgcg tttccttgca 3546841 taaaagtccc tcttccttca aacgctcaca atacggacgt gccgcttcag tcaattccac 3546901 accgataaac agccctctgc cgcggacttc tttaatgaca gggctgtcaa tactctcaag 3546961 ctcgctttta aagtattcac caagttcaag agaacgatcc gccagctttt catcctccag 3547021 cacttctaat gaagcgatag acactgcaca tgcaagcggg tttccaccaa atgttgagcc 3547081 gtgtgagcca gggttaaaca cgcctaggat ctcgcggtcc gccgcaatgc aagagatcgg 3547141 gaacacaccg ccgccaagcg ctttgcccaa gatatacata tccggaacaa tgccgtccca 3547201 gtcacaggca aacgtcttgc ctgtacgtcc gagacccgtc tgaatttcat ccgcaataaa 3547261 caagacattc tcttccttac aaatcgccgc cgcttcctgt aaaaatcctt caggcggaat 3547321 cacaatgccc gcttcgcctt gaatcggttc aaacaagaat gccgctgtat tcggcgtaat 3547381 ggcctgtcga agcgcttcca catcgccgta aggaatgagt ttgattcctg gaagcatcgg 3547441 gccgaatcct cgtttatatt cctcttcaga agaaagagat accgccagca tcgtgcggcc 3547501 gtggaagttc ccgacacatg cgataatttc cgcttgattg tcagctacgc ccttcacttc 3547561 atacgcccag cgtctcgccg ctttcaccgc ggattcaacc gcttcggctc ctgtattcat 3547621 cggcagaatc atctctttgc ctgtcagttt agctgttttt tcgtaaaacg gcccaagctg 3547681 atcgttatga aacgcgcgtg acgtgagggt gattttatca gcctgatcct ttaatgcctg 3547741 aatgattttc gggtgtctgt gcccctggtt taccgcagag taagcactca gcatatccat 3547801 atattcattg ccttccgggt cctttaccca agcacccagc gcttcagaaa taacaatcgg 3547861 gagcgggtga taattgttgg ctccgtaatg agacgtctga tcaataattt ctttggattt 3547921 agataaagct gtcatatttg aattccccct tgttttctgt ttcaacatgt tatcctgctt 3547981 tccctttata taaatgcaag ttctgtgcca aatcaagaat tcgtgtgttt tctacaattt 3548041 tcgaggacaa ggtgcaaaaa cattctgata tttcgagcga aaatttcagc aagtgcaaaa 3548101 ttcttttgca tatcctctcc gtttttttat aaaatagaag caatattaag aaaataattg 3548161 agggaggttc atacagtggt caaagacagc gaattcctca cattggtttt tcagagtatt 3548221 ttagatgaaa tcgatgttgg cctgcacgtg gtagacgagc atggaaacac aatcgtttat 3548281 aacaataaaa tgatgcagat tgaagatatg gagaagcatg acgtcttgaa taaaaacctg 3548341 atggatgtgt ttatgttttc aaagcagcag gacagcacac tggtacaggc tcttcaggaa 3548401 ggcaagacga ttaaaaacgt caaacagagc tatttcaata ataaaggcca ggaaattacg 3548461 acgatcaatc atacatatcc catcgtccaa gacggcaaaa tcaggggcgc cgttgaaatt 3548521 gccaaggatg tgacaaagct ggaacggctg atcagggaga atatgaacaa aaaaggcagc 3548581 acaacctata cgtttgacag tattctcggc accagtccgg ccattcaaga cgtcatcgaa 3548641 aacgccaagc gggcaacccg tacgtcatca tctgtccttc tagcaggcga aaccggcacg 3548701 ggaaaagaac tgttcgcgca aagtatccat aatggaagcg atcgttctgg cggcccgttt 3548761 atttcgcaaa actgcgcggc actgccagac agccttgtgg aaagcatttt gtttgggacg 3548821 aaaaaaggcg cgtttaccgg cgctgtcgac cagcccggcc tgtttgaaca agcccacggc 3548881 ggcacactgc tgttagatga aatcaactcg ctgaatctca gccttcaggc gaagctgctg 3548941 cgcgcccttc aagaacggaa aatcaggcgc atcggttcaa caaaggatac accgattgac 3549001 gtacgtatta ttgccacgat gaatgaagac ccaattgatg caattgcagg cgaacgaatg 3549061 cggaaggact tgtattacag gctgagtgtc gtcacactga tcatcccgcc gcttcgggaa 3549121 cgaaaagaag acattttgct tctcgcgtcg gagttcatcc agaaaaacaa ccatctgttc 3549181 caaatgaatg ttgaacacat cagcgatgac gtgaagcaat ttttcctttc ttatgactgg 3549241 ccgggaaata ttcgcgagct tgagcatatg atcgaaggcg caatgaattt catgacggac 3549301 gagcaaacga ttacggcttc ccatctgccc tatcaatacc gcatgaaaat caagccggct 3549361 gacatcccag agccggaaac accaagacac cagccagccg cggacttaaa agaaaaaatg 3549421 gaaagcttcg aaaaatatgt gatagagaac gtgttaagaa aacacggcca taacatctcg 3549481 aaagctgctc aggagcttgg catcagcaga caaagcctcc aatatcggct gaagaaattt 3549541 tctcactcgt ctaacgaata atccggagca ggaagcctga tcagaaaaac agtgcctctg 3549601 ccgatttcac ttttcacttc aatcgtccca ttgtgattgt cgataatcga tttcgttatg 3549661 gcaaggccta atcccgaacc tccatatttc cgggagcggg atgggtctgc cttgtaaaac 3549721 cggtcaaaca ctaaaaaacg tcacttctta tgcattgaag aaagaaaatg gcacctatgt 3549781 gtatcacagc cagcaaccac acggtacaaa ccattaaagt ccatgcaaat aacggaagta 3549841 tttgcagcta actgccattt gctgtttcac gtgtaacatc catcttgtat ttttcttcat 3549901 attcgatata tcctttttca actgaacggg cgtgacccct gttcagtttt ttttgcatat 3549961 caaaacagcc tggcaacgat gccagactgc ttttattaac tgcctaattg gtctgcggag 3550021 gacagcttga tatcaacaga tttttctttt ccgccgcgat aaaacttcac cttcacccgg 3550081 tcaccgactt ttttctgata aagccgtttt cgcaggtcaa caatatcatt tactttgtat 3550141 ccgtcaaatt ccgtgatgac atccagttcc ttcagccccg cttttccggc aggtgaaaag 3550201 gcgtctacac ccatcacaac cgctccattg gtgacgttct taggaagctt taatgtttca 3550261 tcccaatgat agcttgcgat gtcacttagc gatttcatct caatgccaag gaacgggcgt 3550321 ttgacctttc cgtatctctc taaatcctct atcacaggga tcacgagctt agacggaatg 3550381 gacaggccaa tcccttcaac cgctgactcg gcaattttca ttgaattgat gccaatgacc 3550441 ttcccatcca tatttaacaa agcgccgccg ctgttcccag ggttaatggc cgcatctgtt 3550501 tgcaggactt cagcgttcca gtcaggctgt ccatcaccgt ttgaatctac tgggatcgcc 3550561 ctctccgtac ccgagatgac gccttgtgtg acagagcctg caaactcaag gcctaacggg 3550621 ttcccgatcg caataaccgg ctccccagac ttcactttat ctgaatttcc gaaatcagcg 3550681 actgctttaa tcttatcgct tttcacccgt aaaacggcaa ggtccatcag ctggtcgctg 3550741 ccgacaagat cagctgatac acgtgagccg tctttcaagc tgatttcaat ttgggaagcg 3550801 ccttcgatga catgatggtt ggtcacgaca taagcggaat ggtcattttt cttatagatg 3550861 acgccagagc cgctcccagc ctcgccgctc tctccccaaa tatctgattt ttggatgttc 3550921 acaacaccga caacggcggg cgacatattg ctgacaatct tggtgacggc attgttgaca 3550981 ctgacattca ccgtcctgat tgattcccgg ccattgttgt tttgctgctg atctaaggcg 3551041 cctgtatcca gcccttcatt tgaaaggtac ggcatgataa acgccattaa tacggcaccg 3551101 acaatcacgc caatcagact cgaaagaaaa tatccttttt tgcttctctt tggctgttca 3551161 ggagtagtat gttcttcctc acgttcgtaa tccaccatat tccatccttt ccaagaacgt 3551221 taatatggtt atattgtggg ttagaaactc ctagaatagt catgatttac atagaaaaat 3551281 tatacagcgc aaagcggagt ggccttcttc ggatcggtgt cgtataagtc aaatgtctca 3551341 cccgtcacaa atcctttaga agccaatgtc tgctgcacag acattcttgc cagctccttc 3551401 atgttgttgt cctggctcaa atgcgccagg taaatacgag acgtctcatc gccaatgaca 3551461 tccgtcatcg ccaaggcagc atcttcattt gacacgtgcc cgacgtcact taaaatccgc 3551521 cgcttaatgc tccatgggta tcttcccatt tgcagcatac cgacatcgtg attgctttca 3551581 aacacaaata cattcgctga acggataatg cctttcatcc ggtcgctgac atatcccgta 3551641 tctgtcatta acgcgagctt tcggccgcta taatggaata cataaaacat cggttccgcc 3551701 gcatcgtggg aaacgccaaa cgattcaaca tcaagtccgc cgaacgactt caccgtctcc 3551761 attggaaata caaacttttg atcggtgtca attttgccga tttgattctc catcgctttc 3551821 caagtcttct cattcgcata gatcggaagc ttgtactttc tggcgacgac accaaggccc 3551881 ttaatatggt cactatgctc atgcgtcaca aaaatgccgt ctacatcatc cagcttacgc 3551941 ccgatctgcg ccatcagccc atccatggct tttccgctca aaccggcgtc cactaaaaat 3552001 gcgtgatcct ctgtttcgag gtaaaacgca tttcccgtac tcccgctcgc aagtacgcta 3552061 aattgcaagc tcatgtttgt ctcactccat tattttcatt gatctgtatc taaaatcgta 3552121 ctctccaaag cattcacagt aaaatactct tgtactgtct ttttctcacc gttcactttt 3552181 ttctcgtact cgaccgtaat tctccatacc ggcgccagca cctgcgtact tgtcagcgga 3552241 tattgtgcta catagccgaa tttacagctc ttcacagtgc tgtattcttt taattgattt 3552301 tgatagtaca atagctcaac cgcatccatt tcagtaatta agctttcttt ctggatttgc 3552361 ttgaaggtct caagcgtagt ctggtcgtat gacacaacct cgtttttacc gtttaagtgc 3552421 agcaccactt gcccgatcat attagaggga ttgtcggtct tttggtaaat ataatgacct 3552481 tcgtacgttt ggaagaaaat aatttctttc ttcgatttat caaccttcca aagcttatat 3552541 ttttcgccat cttgaatttt cgaagaaaca agtgcctgag catcgtcctc gatatccttc 3552601 tttgatagtg cgattggatt tgcaaacttc attttcaggc tcgttacttt atgatcatca 3552661 ctaggcatgt ccatcaaagg cttttgatcc ttcagcgcct caatttcctc cttggagaaa 3552721 gacttttgat ttgccgtgat ccgatagcct tctgttgctt ccttattcaa gccttcatac 3552781 gtgatatgat cggccttcat gtcatgctcg acatcatttt taatgacttc atattctttg 3552841 ccggtagcct gccatttttg aaaaaactga tagcctaaga aaatatctaa aatgaggaag 3552901 gcaacgatga agattgattt tgtcttattc cactccactg ttagccccct ccttcctcaa 3552961 taaatccttt gtaatcggca caatttttcc atttactttc atcgcccaaa ccggttccag 3553021 ttcaacgaga ggatcatcgt tggttgatgt tgataccaat tgataagcaa ggaagatctg 3553081 atcaattttg tccgtatcat aagcggtttg tttcgaaagc agcatcttca cttcgctgcc 3553141 gcccatgagc tctgtttcac ttgttttaat cggattcgtt ccgagactgt aattcggccg 3553201 cttatagctg agaatatcat cattcgccca ttgcaccgta atcgccgatg tcgccccgaa 3553261 aggtttggcg gtgctgttaa tgaccgggat ctgatccata aaaatataga agctcaactg 3553321 ctggctgtca ttgatattga aaaattgata gtgatccgtc cagcttccgg tatcctcaag 3553381 gtatttttgg ctctttttga ttaattcacc tgtttgatag gatgtgctct gcaccaaatt 3553441 gcgctgctga aattgcacct gtctctggct tagattcaca tctaaccggc tgatcccatc 3553501 tgtcagcaca tttctgttgg tgtaattcga atcttctctt acaatgctcg gatcactaaa 3553561 caaagcctgc ttaaaggtat ttgttttaat cgattctgtg acaaattctt ttttgtccat 3553621 cgtaagcggt ttgttcggca gcaagaactc tttctttgag ccaatggaga acaaactgaa 3553681 cgccggcata tttgattgcc tgtttttcaa gtcgttcata atgttccggt agtttgctga 3553741 ttcaaccgtc acttcaagaa tgagctgctt gctgtatgac accaaataga ttttcttgtt 3553801 cgcttttgtt tcattgaacg ggatcagaat atggtcaaac gaactgtatt caaacgactg 3553861 attagaccat ttaaacagcg tttggaaaat atcaatcggg atcgtatcgc tgaattgcaa 3553921 gtcaagcttg gcttcagaac cgcctattcc ataaaaccag cttttgaatc cagccttgtc 3553981 atactgatcc gaaatatctt taattccttt cacatcccaa tgcggcaagt cagaccaaat 3554041 ttcttcatag agggcattgt catccacttt gtaatgagcg ccgtcatcat ggataaacat 3554101 gtcccttggc cttaccgttt cagacagctt ttgggtggtt ttttcgattt tatgtttcac 3554161 acgaacagta gactctgttg aggatgagcc ttcagaaaag tttggctgga acgtccatat 3554221 cccccatgta aaaacaagac tgatgacgac gagtaccgta agtaatatcg tttttatatt 3554281 ttcacgcttc atcccaatca tcctcttgtt cctctttata tggaagagta aatgtaatcg 3554341 tcgtgccttt tccttctatg ctgtccgccc aaatatctcc accgtgcgcc tgtaccattt 3554401 ccttggcaat cgccaatccc agaccggtgc cgccaagctt tctcgttctc gctttatcca 3554461 ccctgtagaa gcggtcaaag actttttcga catctttttt cggaatgccg atcccttcat 3554521 ccttcacgct gatatagaga agttcttcct cttcattgac atcaatcgag aacgtgacat 3554581 gtccgccttc cggtgaatat tttaaagcgt tagaaataat attatcgagc acctgcgtta 3554641 ttttatcctg gtcaatctcg acatacagat ctctgtccgg cagattgcgg ataaactcca 3554701 catgctgctc ttttgtcatt tcaaaacggt caataataag tgacataaac cggacaatct 3554761 gaatccattc ccggttaaat tgataatctt tactgtcaaa tttcgacagc tgaagcagat 3554821 cattgacaag ccggatcata cgctctgttt cattttgcgt caccattaag aagcgcggag 3554881 caatgtcttt attttcccac gcgccttcag ctaacgcttc taaatagctg cgcattgtcg 3554941 taagcggcgt ccgcagctca tgtgatacat tcgcaacgaa ttctctgcgt tcctgatcca 3555001 ttttctcttg ttcggttaca tcgtaaatga cagcgattaa accatcaatt ttgccgtgtt 3555061 ccctttgaat cacagagaaa ttcacgcgaa gcaccgttaa ttcatcatcg cgctcaattt 3555121 caagcagcat agaatcctgc tgttccacta aatcttcaaa agtataattc tcttgaagcc 3555181 ccagcaaact cgtaatcggc atttctaagg ctgtttcacg tgaaacgttc aacagttcca 3555241 gcgccgggct gtttaagaga ataatcgctc cgtttcggtt tgtggcgata acgccgtctg 3555301 tcatataagc aatgacagag gctagctttc tgcgttctcc ttcagtcatc gcctgggcat 3555361 cttcaagctc tctcgttaag tggttaaacg ttgtggccag ctgcccaatt tcatcatgtc 3555421 catacttttt aaccttcctc gagaaattcc ctttcgcaag ctccatcgcc tgctttcgca 3555481 tatctgaaag cgggtgggta atggttcttg ccagaaaaat accgagaaga gccgtcaaaa 3555541 caagtgccaa acctgtgccg gacgccagta tcgtgttgat cgtcttcatt tgattaaaga 3555601 catcttccat actcgcgaca acgtagatcg cgcccacaac ctcttggttt tcagtcatga 3555661 cgggcttcgc ggaaataaga actctgattt tgcttttcgg gtcataatat tttcttaaat 3555721 acgactgttt ggtagaaaag attcttttga aaatcagatc ggtcgtttgt ttcccagcca 3555781 cttcctcacc gtacggcttt gaagaaccga ccacttcata gcttttatct acaaagctaa 3555841 tttcccgaac ctcatcactt ttcgtgaagt cattcaaaat acggctgacg tcatccttta 3555901 tgacggtact gtcgttatcg ctcttatatt cttgttcgat ataataagaa aggttgtcga 3555961 ttcgctgatt cagcgattgt tcataagagc tgatcagcga cttctctacc tgattgacaa 3556021 aatacacacc aatgatttgc atggcaatga taatcaaaag cacataaatc aaggtaatct 3556081 taaattggat cgaccgaaaa aaaccaacct tattcatatg ggcattagtc ctgttctggg 3556141 tttctcaagt aataacctac accacggcgt gtgacgatcc aatttggatg gctcgggttg 3556201 tcctcgattt tttcacgaag ccggcggact gttacgtcaa ccgttctgac atcgccgaag 3556261 taatcatagc cccaaacggt ttgaagcaaa tgttcacggg tcatcacttg tccgatatgt 3556321 tttgctaaat aatgaagcaa ttcgaactca cgatgagtca attcgattgt ttcgtctcgt 3556381 tttgatacaa cgtacgcgtc agggaagatg acgagagagc cgatatgaat ctcgttagag 3556441 gaaggctctt cctccgcagg cgctgttgtc agctggcggc gcaggttcgc ttttacacgc 3556501 gccaagagct cgcgtgtgct gaatggtttt gtgacatagt catcagcacc gatttcaagc 3556561 ccgataacct tgtcaatttc tgaatcctta gccgtcagca taatgattgg catatcgtat 3556621 ttctttctga cttcgcggca tacttcaacg ccgtctttat ttgggagcat aatatctaaa 3556681 agaattaaat caggctgaag ctcttctacc atttcaacgg cttcgtttcc gtcgtgggca 3556741 cagtgcactt catagccttc ttttcttaag ttaaattcca atatatctgc aatcggtttt 3556801 tcatcatcta ctacaaggat ctttttatcc atcattttga ttttcctcct gccgaatgac 3556861 ttcatttcat ctatataaca ttcgtttcat cacttatggc ccatgtaaag aatgggtcct 3556921 tgtctattat aacggtttaa ggtcaaaaga taaaaaaaat aaaggtttag aaaaaaaaca 3556981 catgtttcac ctttatcgcc agttgtttat ctattgtcat gctggtcaac tttttttaaa 3557041 aaagataact ttattgaaac ctcccctcac cggagtgcgt ctttatcaat gacgtcttct 3557101 tctttgaacc ggccgcaggg ccggttctcc ctttttcttc tattataaca ctcctcatgt 3557161 ttgccttttt cctaaaagaa aaaacgcacc tacgattgca gatgcgtttg gtaagtggct 3557221 cgggacggaa tcgaaccgcc gacacacgga ttttcagtcc gttgctctac caactgagct 3557281 accgagccaa atgttttatt tttctctact aagtaaagta aaatggcggt ccggacggga 3557341 ctcgaacccg cgacctcctg cgtgacaggc aggcattcta accaactgaa ctaccggacc 3557401 ttacagtaat tgcccggaga gctgtcgtgt cagctctcac agacaaataa ggaatttagc 3557461 aataacgcta aagtaaatca atgacccgta cgggattcga acccgtgtta ccgccgtgaa 3557521 agggcggtgt cttaaccgct tgaccaacgg gccttcacga aatggtgagc catgaaggac 3557581 tcgaaccttc gaccctctga ttaaaagtca gatgctctac caactgagct aatggctctt 3557641 aaagatgtcg gaatttctat agagcaaacg acttaaatct agttctcatc ttgtactcta 3557701 ttgaagcagt ttccgtaaca acgagattta taatatcacg aacaaataga agtggcaata 3557761 acttttttgg ttttttttca tatttttttc tcagaccaac ttatatgcgg ctttcaaaca 3557821 aaaaacaagc cccttaaata ggggcttgca gacatattct atttagttcg cacggtacac 3557881 actgcgaagg acatttgttt gtgagcggtc tggaccgaca gagaaaatag aaagcggaat 3557941 gcctgtcagc tgagacacac gctcaagata atggcgcgca ttttccggaa gctcgctcaa 3558001 gctcttcgca cctgtaatat cctcagtcca gcccggcatt tcttcatata ccggctcaca 3558061 ttcagcaagt gccttaagac ttgctgggaa ttcttcaatg atttcgcctt tgtagcggta 3558121 cgccacacag attttcaacg tttcaattcc tgctaggacg tcaattgagt tcagagaaag 3558181 atctgtaatt ccgctcacac ggcgggcgtg gcggacaaca acgctgtcaa accagccgac 3558241 acggcgcggg cggcctgttg ttgttccata ttcgcgtccg acttcacgga tttgatcgcc 3558301 gatttcatct ttcagctcag tcggaaaagg accgtcgccg acacgagtcg tatatgcttt 3558361 tgatacaccg acaacgtgct tgattttggt cgggccgaca ccagaaccga tcgtgacacc 3558421 gccggcaacc gggttagatg acgtaacaaa cgggtatgtt ccttggtcga tatcgagcat 3558481 aaccccttgt gcgccttcaa ataatacacg gcgcccttca tcaagagcat cgtttaagac 3558541 aacagatgta tcgcaaacat actttttaat ctgctgtccg tactcataat attcgtctaa 3558601 gatatcctca agtttaaacc cttctgtctc gtacattttc tcgagaagac ggtttttttc 3558661 ttcaagattg cgctcaagct tttccgcaaa cgcgtcacgg tctaacagat ccgcgatgcg 3558721 aattccgatg cgggctgctt tatccatgta agcagggccg attccttttt tcgttgtgcc 3558781 gatcttgtta gcccctttac gctcttcttc cacttcatcc aatttcaaat gatacggcag 3558841 aatgacgtga gctctgttgc tgattctcag gttatctgta ctcacgttgc gctcatgaag 3558901 atacgcaagc tctgtgacta atgctttcgg atctacaacc attccgtttc cgattacaca 3558961 cgttttatcc ttatagaaaa ttccagacgg gattaagtga agcttatatg tgattccgtc 3559021 aaacttgatt gtatgccctg cgttatttcc gccttgataa cgggcgatca cttctgcatt 3559081 ttctgatagg aaatctgtaa ttttaccttt tccttcatcg ccccattgcg tacctactac 3559141 aactactgaa gacatgtccg tgcacctccg ttaacctttc aaaacgattc tattcaaaca 3559201 aatcaagttt atcagtgaag aaacagaaag tcaattgtaa atccgaacat taatttattg 3559261 taaatctata ttcgttcgct tccattcgtt ttataagcgt tttctcactg ctttgtcata 3559321 aaaagcttgc gaaactttca tcctttagca taagaaagaa tcacttgcct gatatccctt 3559381 ttgaattcat aaaaacgatc cgccagccgt ccgggtcctc tatcgtcacg cccccattgc 3559441 tccagtacgg gttctctgat tcgacctctt gatagcccat gtgctttagc tttgaagtga 3559501 tcgctgccag ttcaactgca ttcggcacat aaaaaacaag aaggctgtcg ggatggggaa 3559561 cgggggcagt gcttccccct tcatactggg tgaattccaa atgataatcg gcatgaggaa 3559621 ggccgaacat gacaccgtca tacccgttat gctgtgaaaa ttctcctatt cgtttcaaac 3559681 acagtccctc ttcgtaaaaa cgaataatct catcaagctg gcccgtagga cgcgcaattc 3559741 ggatttgtgc tgcttgaaaa gacgaaaaac gttttcccat attgttacca tctccttttt 3559801 gcaccatttt attaaaacgc tttcaatttt tcatccgctg agcgaacgtc atttcttcca 3559861 tctttcgaat gaaaaaaacc ccaagagcag ctcttggggc ttatgcgccg ggcggaacgc 3559921 ctgcgtcatc aaaacgccgt tccaggttga cgaatttgtt gtattctttt acgaacgcaa 3559981 gagacacggt tcctaccggg ccgttacgct gtttggcgat aataatttcg ataatatttt 3560041 tattctcggt ttctttgtca tagtagtcat cacgataaag gaacgcgaca atatccgcgt 3560101 cctgctcgat acttcctgat tcccggatat cagacatcat cggacgttta tcctgacgct 3560161 gctcaacacc cctggaaagc tgagaaagcg cgataacagg gacttgcagc tccctcgcaa 3560221 tcgacttcag ttcacgggaa atttcagata cttcctgctg acggttgtcc tttgaacgac 3560281 cgcttccctg aatcaattgc aggtaatcga tcaaaatcat gcccagcccg ctttcctgct 3560341 tcaagcggcg gcacttggca cggatttcac tcactcgaat acccggtgta tcatcgatgt 3560401 aaatcccgct gttcgatagg cttcccattg ccatcgtcag cttgccccaa tcctcttcgg 3560461 tcaggttacc tgtacggaga ttctgggcat tgatatttcc ctcggcacag agcatacgca 3560521 taacgagctg ctcggcaccc atctcaagac tgaaaatcgc tacgctctca tcggtcttcg 3560581 tcgccacgtt ttgtgcgatg ttcagggcaa aggctgtttt ccctactgaa ggacgggcag 3560641 ccacaatgat caagtcgttg cgctggaaac ccgcagtcat ccggtcaagc tccgtaaacc 3560701 ctgttggaat tcccgtgata tcaccttttc gattgtgaag ctgttcgata ttatcatagg 3560761 tctggacaag gacgtcctta atattttgga aggcactcgt gtttttgcgc tgtgccactt 3560821 ccataatcgt tttttccgct tcactgagta aatcctcgac ctcatcctca cgggtatacc 3560881 cgtcttgagc aatcgttgtc gcagttctga ttaatcggcg aagaatcgat ttttcctcaa 3560941 cgattttcgc gtaatattct atgttagccg ctgtcggcac cgagtttgcg atatctgtca 3561001 aatatgaaat accgcctact tcttccagca ggtctgtgtt cgcaagctct gatgtaactg 3561061 tcaccagatc aaccggttca cctcggtcac cgagcaccag catcgcatta tagatttttt 3561121 ggtgggacat tctatagaaa tcatctggaa tcaatacttc tgaagccagt gttaaagcag 3561181 acggctgtaa aaaaatagcg cctaacacgg cttgttcggc ttctatattt tgcggaggaa 3561241 gccggtcatt cagaaggtct gtcatgctaa gcaccgtcct ctcattaaaa aatctccaac 3561301 ctccattcta ccatttctac agaaaaaaaa tagaaaaatt gtctgtttcc tgtttttttc 3561361 agttagcaga ttggatcgtt tcggacagta acaaggcggg aaaaatgcaa taaaacataa 3561421 gggaggaatg aaagatgata aagaaatatg cgattacacc taatgttgat gcggacggct 3561481 ggtttattga ggtggagaat gtagcgccga cagctttgta tacgtctaaa gacgccgcta 3561541 ttgaaaaggc caaacaggtg gctaaggaaa acagtccgtc taagcttgta atttatgacc 3561601 agtttaaaaa tgtggaagaa gaacactcat tttaatgaat gaaagccttc gctgcagcga 3561661 gggtttttta gcggttatcg gtttatttca tccattggat gcctatgtgc atcatcaaat 3561721 ctgccgcttt ttgatacaga tcccactccc cgatcgaagc aaatttcccc atcagctcct 3561781 gaagctttaa cctcattgct atatattctt cgaaagtgac agctttttca gtgtctattt 3561841 ggtgttcctt cagcatttgt tttaataagg ataacggtgc gtgcataaga accctcctta 3561901 cctcttttat aacggtcatt ttccgattgc tctattcctt tgtgacatct tcttacattt 3561961 cacatctgat tcttgtacaa tggacagaag agaggaggga tcttttgtga gacctttgca 3562021 aatttctgcc gaaactgcac aaaagcttgc agagtccttg aatctgccgc ttgaacagat 3562081 catgcatatg cctcagcata ttctgcttgc caaaatggct gaactgcaaa aagaggacaa 3562141 atcatagcct tcattcacat acttgcttac ctgtttcggg ataatatcat gtatatgtta 3562201 gaaaagagga gtaactgctt tgccacatcc acataataaa aaaatccaat cattttggct 3562261 gatcaccggc attatcttta tcgcctttaa cttacggccc gcgatcactt cagtcggtcc 3562321 ggtcatcagc tctatccggg cagagctgca catgtccaat ggggcagccg gttttttgac 3562381 cgcactgccg ctgctttcgt ttgcagttct ttctccgctt gcacctaagc ttggacagcg 3562441 cctcggtaat gagcgaactt tatggctagg tctcgtgata ctgctgatcg gtgttctgac 3562501 tcgttctacc ggctatactg ccgctttgtt tttcggaaca gcacttatcg gcgtcgggat 3562561 tgcgattggt aacgtacttt tgccaagctt aatcaaacat aaataccctg aaaagccagg 3562621 gatcatgatc agcctgtata cgacatcaat gaatatattc gcagctttag catcgggtgt 3562681 cagcgttcct ttagcgaccc agatgaatgg cggatggaaa caagcctttc tcttatgggg 3562741 cgggctggct ttacttgcat tgctaatctg gatacctcag ctgcgccatc gagatacggc 3562801 aaaccagaca atgaagctgc aatccagttc catttgggct tccaaaatgg catggtatgt 3562861 caccatcttt atgggcctgc aatcgttttt attttacagc agcatcgctt ggtttcctga 3562921 aattctccgt tcacacggga ttgatacggc aacagccgga tggatggtat cactcatgca 3562981 atttgcgagt ctgccttcca cttttctgac gccagtttta gctgaccgtg tgaaacagca 3563041 gcgcggtatc gttgcggcgc tggcctcagt ttatctgatc ggcctttgcg gattattagc 3563101 gggcggaagc catacattgc ttgccatctg gatgatcatt atcggtatcg gacaaggctc 3563161 cagcattagt ctggccctta ctttgattgg tctccgcagt gaaaatgccc aacaggccgc 3563221 tgcgctgtca ggcatgtctc agtcattcgg ctacctgctg gcagcagtcg ggccaatctt 3563281 tgtcggctat ctctttgacc agacgcattc ttggacgatg ccgattgtgc ttctcattgc 3563341 tgccctgatc gtaatgggag cagccggaca gggagccgga cgagatcgat acattttcca 3563401 gtcagaaaaa caaagaaatt cagcataaag cggggaagat atctccgctt ttttctttga 3563461 atatttatgg tttattcata agtttttcat atttgttttt tacaatgaga caccataaag 3563521 aggtgaaaaa cgatgaaaac caaacgattc gacgcagccc ttattcttat tttgctagca 3563581 gcagcttttt tgaatacgta tcacatttgg caggatgata cagcaaacca gtactatttg 3563641 gcggctgtaa aaagcatgac gcaaagcttc cataactttt tttatgcgtc atttgaccct 3563701 tctggatttg tgacagtaga taagcctcct gtcgtgttat ggattcaaac gattttcgca 3563761 ctgattttcg gtgttcacac gtggagtgtc atcattcccc aggctcttgc cggagttgga 3563821 tctgtcttcc ttctctacag aatggttaag ccgacttttg gagttggagc ggcccgcatt 3563881 gccgcacttg tcatggcact gacccctatc gcagtagctg tcagccggac aaacaatatc 3563941 gacagcatgc ttgtttttac cttattgctc ggttcaactt gtctgcttag ggcagtaaaa 3564001 caaggcaagc tggtttggct gctgacggca tttgccctga ttgggctcgc ctttaatatg 3564061 aagatgatgc aagcgtttat ggtattgcct gcatttgtgt tattctacct gattgcatct 3564121 cgggtttctc tgaagaaaaa aatcgggtcc ctgcttctgt ctcttgtcct tctgacaggc 3564181 ctttcactct catgggcgat tgcagtggat tcagcctctt cctcaagccg gccttatgta 3564241 ggaagcagcc agactaactc agtgctagaa ctggcctttg gctacaacgg cacagagcgt 3564301 ctgtttgggc aaactacggg ccttgcaaag ggtgatatga atgctgctgg cggagggaac 3564361 atgcagaatc aagacaacat gcaagcgcca aatggcaacg gttcatcttt ttctcagaac 3564421 ggtaatcaat cattcggaaa ccattcacag gcgcctcagc cgcctaacgg acaaaccggc 3564481 gctctcaatg gaggcggagg cacacctccc acaggtggca acggacctgg aaatggaggg 3564541 cctggcggcg gaggcggaaa aagcgtgaat atgttcggca ccggtgatcc tggaccgctt 3564601 cgtctcttcc aatcagcact ttccggccaa atcagctgga tgcttccatt ctcattgatc 3564661 ggattactgg gcgcaatcat cagctggtac cgtgatcgcc gcggacatgc tgctaaaatg 3564721 aaagaaacgc tattctgggc ggcttggctt gttcccgtgg ctggtttctt cagcatcgca 3564781 ggattcttcc accagtatta tttgattatg ctggcaccgc cgattgccgc cctttctggt 3564841 atcggatggt atacgatgca ccgcttatac aaaaataata aagactggtc cagctatctt 3564901 ctgccggcag ccgtcttgat cacagccgtg tttcaggtgt atattctgag cgcttataca 3564961 agccaaatcg gcagtgtatg gatgtatgtc ctggggctct taggactggg catcaccctt 3565021 gcacttctga tgcttaaacg cagccatccg ttcagtaagc tgctgaccat catcagcttg 3565081 tgcgttctgc ttctcacacc agtttactgg tcagcaacgc cgcttctata cggtggcaac 3565141 agcgtccttc ctgaatccgg cccgcagctc aaaggctcag caaacggcgg gaacatgttc 3565201 tcttcagagg tcgacagcgg gctcctgtcc tatctgagaa aacacaatac cggcgaagag 3565261 tatttatttg ctactttgac aaccgtaaca gctgcgccat acatcattta cgaaaatgaa 3565321 tctgttatgg caatgggcgg gtttaacggc acggatccca ttctgactgt gtcggaactg 3565381 aaaaaactga tcaaagaagg caaagtgaaa tacttccttc tgtcagaaaa caactcaggc 3565441 aacagcgaac ttgtttcctg gattaagaaa aacggaaaag aaataacatc tgacgagtac 3565501 agcggttcct ccagcagcac aaacagcgtg cagggaatgc gaagaggacc tggcggagaa 3565561 agccagcaaa ctctttatct cgtggaataa aaaaagaggc ttggatgaat ccaagcctct 3565621 tttctattaa gcttcttctt ttacatgtac ctttaacaca gcctgcactt caggatgcag 3565681 cttcacaggc acgtttgtat atcctaatgc acgaatgccg tccggcagtt caagcttccg 3565741 cttatctact ttaatgttat ggtctttttg gagctgttca gtgatttgct tgcttgtcac 3565801 tgaaccaaat aaacggccgc cctcacctga ttttgcgcta agctcaacag tcagtttttc 3565861 taatgtctct ttcaagctct tagcctgctc aagctcagca atggcttctt ttttctcttt 3565921 ctgcttttgt ccgtttaacg cgctgatgtt tgacgcgttc gcttcaaccg cgaggccttt 3565981 tttaattaga aagttatgcg cataaccgtc tgctacgttt ttgacttcgc ctttttttcc 3566041 ttttcctttt acatcttgta agaaaataac cttcatctct gtacgcctcc ctcaaaatac 3566101 tcatctatgg cgtgcttcag ccgttccagc gcttcagaaa ctgaaatgcc ggacaactga 3566161 gtcgccgcat ttgttaaatg ccctccgcct tccagggcct ccatgatgat ctgaacattt 3566221 acctcgccaa gcgaccgagc actgatacaa accgtttgtt catcccgtct cgccaccgca 3566281 aatgaagcct caacctcact catcgatagc agcgaatcgg cagcctgcgc aatcagcact 3566341 tgatcgaagt attcctcttc attttcagga agagaagcaa tcgcaatgtt atctttatag 3566401 aggaccgtat gctggatcag cttcgcccgt ttaatatagg aatcaacggt ttctttcaga 3566461 aacttctgca ccagcaccgt gtcggcgcct tttgccctta aataagaagc cgcatcgaaa 3566521 gtccgcgagc ccgtgcggag agaaaagctc tttgtatcca ctattatacc agctaatagg 3566581 gctgttgctt caatcatatt gatttttaag cgcttcggct gatattcaag cagctctgtc 3566641 accaattccg ctgtggaaga agcgtatggt tccatataaa cgagcagcgg atctctgata 3566701 aactcctcac ctcttcggtg atggtcgatg accacgatat gttcaatttt attgaccagc 3566761 cgttcctcca tgacgagtga cggcttatgt gtatcaacga tcacaagcag tgtgtcatca 3566821 ttggaaatct ccattgcttc ttcaggcgta ataaatcttg accacagttc ttcatatttt 3566881 ttgatttccc caatcaaacg ctgcacactt gatccgattt ggtttgggtc aatcacgata 3566941 aaaccatctt tgttatttgc ctgagccacc tttaaaatcc cgatcgctgc gccgatagaa 3567001 tccatgtcgg ggaatttatg ccccatgata atcacattgc tgctttcggt gacgatttcc 3567061 tttaaggcgt gagaaatcac gcgggcccgc acccttgttc gtttctccat tgggtttgtt 3567121 ttaccgccgt aaaacttcac cttgccgttt ggcagcttaa tggctacctg gtctccgccg 3567181 cgtcccagtg ctaagtccaa gctggattgc gccaaatcgc caagttcttt cagggaagag 3567241 actgaagccc cgacaccgac gcttaacgtc agcgctacac cgtcaaacga ggttttttcc 3567301 cgcacttcat caagaatcga aaacttcgaa ttttcgagtt cagttaagat atgttcatta 3567361 agtacagcaa taaagcgttc tgaagacgtc cttttcaaga agatcccgta ctcctgcgcc 3567421 caagcgttca gcaaagatgt cacctggctg ttcatcgtgc ttctcgtctg gtcatccaat 3567481 ccttgtgtca catcatcata gttatcaagg aaaatatatg ccaggacggt tctttcgttt 3567541 tcatatagct tttcaatctg gatttgttct gttacatcaa agaaatataa gagacgctca 3567601 tcccgtttga tgacaaccct aaacttgcgg tcattcaatg taaccgtttc cgattccacc 3567661 tcttgtttga taagcggcac taccgattca caagtatcgt aaagtgatct ccccactaaa 3567721 gtgctttcat taaaacaaga ggaaagaaac ggatttgccc attctatata atattggtca 3567781 ttaaaaagca tgattccaat cggcatttcc atcaatgcct cttcaccgac ttttttcaac 3567841 ctgtaggaca acgtagaaat ataagcatca atctcttgtc gaataagaga atcagcacgc 3567901 ttaataaaaa acaaaataac tgccagcagc agcacttcga cggttcctaa tatccagtta 3567961 aaataaaagc tgatgaggat tgtaataatt gacagagcaa tcaatgcata gatgggatac 3568021 cgaaacagcg gtttttcata aaagcttggc atttctatca ctccccacca tgtgagtaaa 3568081 actcatgttc acttcacctt attccttata tgaaagccca tatctaaaac gcctaaaatg 3568141 cgaatggccg ccatgaagac cggatgcaca aacccaagta tgacagcaat cacagccgca 3568201 gcctttggat attgtttctt atggcaatag aaaaagataa atgataaacc ttggatgaaa 3568261 atcagaaacc cgagtataaa ctccccattt aaagcgatag agtacagcat ttggcctttt 3568321 tctaaaggca aaaatgaaag catgacaata atcaaataca gtactacaac actttgcgga 3568381 aacttcaact ctctaaaagg ctttagatta ggaatatcgg gggagaatcg ccttaagagc 3568441 ggcttagcga taaggtaact gaggaaagaa aaaataactc ctaccatcac aatagctgtt 3568501 ggaaaaagat attgaacgat acccaattgt tcttccatca gttttaattg cttctcaaac 3568561 tgcccagcat tgcccgactg cttcgctaca gtttctacaa tatcaagaga ttgccggtat 3568621 tgtgtcattg cctcatcaat gatattgata cccaaaaact gaatgcttat cacaaaatag 3568681 aagacaatac taagcatata aataagagcg cccgaaataa tggcgtgccc gggctctttc 3568741 cttttgaaaa aatgtcccat ggcaatgccg gcgcaagctg acataaaagc tacaataagc 3568801 ccgttaaagg acccgacaat aaaaacaacc ggaagactga cagcgcccat ccatatccct 3568861 agcttcaatc catgtctgat cgtatacaag atcattggca gcggcagtgc aaataacaga 3568921 attgttccaa tcacaggaac ataaacgacc agaagcgtaa tgatcgcaaa cagactgatt 3568981 aaaatagcac cttccattaa agctctcgtt tgtttcactt agtcacctcg tatcatcctg 3569041 aacatacgaa tagaaaagag cagcataaac gactgctctt ttgttcatcg ctgcaacatg 3569101 ctttgcaccg aatgttttta tatcatctct aaattttact tttatatttt aacataagtc 3569161 caaatcgcaa gtaaaatgac gctaatgttt catgtgaaac atgaaaaagg aaaagacatt 3569221 ctttgaaaag aatgcccatc acaattaatg tttatcatcc ataaagccag aagattcctt 3569281 gtttttcttt ttcgtttttc tgacatacat aaaaattaag atcaccagta aaagggttgt 3569341 tgcttgcaga acgccgctgc taaacaagaa aaagttcttt atcatgtccc acattgtgtt 3569401 tcacctcttt gtgcatgttc tcaacccgta tcctatataa ggtgaatttc cctttttaaa 3569461 aacttcaaaa catcatgaac aacattgagc gttgggcata tgctgatatg gaatctgatc 3569521 gataaaggag aattttcaca tggatgaacg cagaacattg gcttggcatg aaacattaga 3569581 aatgcacgag ctggttgctt ttcaatcaaa cggactcatt aaactgaaga aaatgataag 3569641 agaagtaaaa gaccctcagc tcagacagct ttataacgtg tctattcagg gtgttgagca 3569701 aaatttgaga gagcttcttc cgttctttcc acaggctccg cacagagagg atgaggaaga 3569761 agaacgcgca gataacccat tttacagcgg tgacctgctc ggttttgcca aaacatctgt 3569821 ccgcagctat gccatcgcaa ttacagaaac agcaacacct caattaagaa acgtactggt 3569881 caaacagctg aatgctgcca tccagctgca cgcccaagtt tatcgataca tgtatcagca 3569941 tggatattat ccgtcttaca acctttctga actgttgaaa aacgatgtca gaaacgccaa 3570001 cagagccatt tcaatgaaat aaaacaagca gcaaaggagt tccctttgct gctatttctg 3570061 ctgatccttc actaagccgt tcgaacgata agattccagc acgtctctgt tggattctcc 3570121 ccattctttc atttgcaaaa caatcggttc aagcgtgcgc ccaaattccg tcagagagta 3570181 ctctaccttg ggcggcacct ggtgataaac ctcacggtgc acgatgccgt ccgcttccag 3570241 ctccctcagc tggagagtaa gcattctttg agtaatactc gggcagattc gccgaaactc 3570301 attaaatcgt ttcttgccat ctatcatgtg ataaaaaaga attcctttcc actttccgcc 3570361 aatgacatct agagtgaatt caactggaca gccttctttg ttcgggtata tattcttttt 3570421 ttcactcatt cttgaccctc caatagtacc ttttttgata ctacattaca ttttgcaact 3570481 aatctaccca gtattttaca caccttttct ccttagctca aagaaaatgc ttcttattca 3570541 catcaatttt taagggtttg catgattaca cctgcagcaa gacgtgttaa actatataaa 3570601 gattacacta cttaaaaaag gataggagct atcatggaaa agatacttat tttcggacac 3570661 caaaacccag atacagatac gatttgttct gcgattgctt atgctgattt gaaaaacaaa 3570721 ctcggcttca atgctgagcc tgtccgcctc ggacaagtca acggcgaaac acaatacgcg 3570781 cttgactatt tcaaacaaga aagcccgcgt cttgttgaaa cagctgcaaa cgaagtaaac 3570841 ggcgttatcc tggttgacca taacgaacgc cagcaaagca tcaaagacat tgaagaggtt 3570901 caggttttag aggttatcga ccatcaccgc atcgctaact ttgaaacagc tgagccgctt 3570961 tactatcgtg ctgagcctgt aggctgtacg gctaccatct taaacaaaat gtacaaagag 3571021 aataacgtga aaatcgagaa agaaattgcc ggccttatgc tgtctgcgat catttctgat 3571081 tccctgttat ttaaatctcc aacttgcacg gaccaagacg tagcagcagc aaaagagctt 3571141 gcggagatcg ctggagtaga tgctgaagaa tacggcttga acatgttgaa agcaggcgct 3571201 gatctaagca aaaaaacagt ggaagagctc atttctcttg atgcgaaaga atttacactc 3571261 ggcagcaaga aagtcgaaat cgcacaagta aacacagtgg acattgaaga tgtaaaaaaa 3571321 cgccaagctg aattagaagc tgtgatctca aaagttgtgg ctgagaagaa tcttgatctg 3571381 ttccttctcg ttatcacaga tatcttagaa aatgattcac ttgctcttgc aatcggtaac 3571441 gaagcagcga aagtggaaaa agcgttcaac gttacattag aaaacaacac agccctctta 3571501 aaaggcgttg tttcccgtaa aaaacaagtc gttcctgtct taacagacgc aatggctgaa 3571561 taagcaaaaa gcatcccgcg tcgggatgct ttttcttatt cacccagctt ctcaatttgt 3571621 cccatcacat cagtaatttg ctttgcgttt tggaccaggt ctgactgctc caattcttta 3571681 agcgatacct tgccttcctc ggcttgtttc aacacatctt cagcgctttt ctgcaaggtt 3571741 tcgttatgct cctgaatggt tcgatgaatc tccgctgcgg catcaggcgg cgttaattca 3571801 ttaaaatcag cggcagcctt ctgaatcgac tcaagctgcg cttcaagttt ttctttcgcc 3571861 tcggtgtcat ttacagcttt ctcagccaat tcaggcgctt cctctgcaaa tgtcttcacc 3571921 ttctccacat aaccagctgc ttcactcgta tagttcaatc cgtcgttcac ctgatcaagc 3571981 atgccgcatc cgcctgcact caaaagtccc actccggcaa gtactgtcaa aatgatcttc 3572041 atcttcagcc ccctcatcgt ttctttttca ttttttcttt taagatcgga atcaatttct 3572101 ctttcgctaa cggcagccct ttcctcacca attcacgctt cagccacttt ttcagcttag 3572161 acattctgat gctcctctcc ctttttgata aaaatgaaaa aactccacca atttggtgaa 3572221 gttcctgaaa caaaaagacc ttcaccaaat cagatttggc aaaggtctcg ctaacaatga 3572281 gattgccagc aaagccgagg acaccttgtc ccgtaatgac gactttactg tgaaagctac 3572341 tcccctttgg agtgttcatt tttattactt tcattctaaa gcaccgatct gttccagtca 3572401 aattcctgcc gtttatataa aagcgcgctg tggtatttaa aatttgaatg gtttttctat 3572461 caggagatca tgctatgaca gaggaggttt tcatcatgag tcaagagcgc gtgaaacggc 3572521 ctgggcatac cagatggtac atatcttcgt tacttagcgg cattattatt cttaattatt 3572581 ttgaccgagt ggccatctcg gtagcggccc ctgcgataca agattcgttt caccttactg 3572641 caactgaact cggcatcgtg ttttccattt acacctattc ctatacactg atgcagctgc 3572701 ctgtcggaag tttgctggac cgttttgggg tcgcatgggt cacgagggtt ggaatgacaa 3572761 tatggagctt tttaacgatc cttcttgctt ttttgcaagg aaaattgctg ttgtatctgt 3572821 tccggtttct cattgggctg acgagcgcct ctgcgttccc tgctgcctct aaagcaaccg 3572881 ctctctggtt tcctccaagt gagcggggat tggcaaactc actgttcgat tcggccgcca 3572941 agttttcaaa tgtaatcggc gcgccattgg tcgcctttct tgtcacaaca tttgactggc 3573001 gtgtcgcttt tttgacgatt ggatgcatca atgtgctgtt tacgatcttt ttctggcagt 3573061 attatgaaca gcctgaacgg cacaaacgca tttctaaaag tgaactaaac tatattcaaa 3573121 aacacaatgc cattacaaca gagcaaatcc cttacaaaac gggcccgctt ttaaaaaagc 3573181 ttttcaccaa tcgaaaagta tggggcttaa tgatcggatt tacagggtac gggtatacat 3573241 tcaacctgct gctcacctgg cttccgactt tctttaaaca tacatacggt atggatctca 3573301 tgtcgtccgg tttatttacg gcagtgccgt ggctgatctc aaccatttcc ggaattgccg 3573361 tcggcggctg gctcgtcgat tattttatta agaaaggcta tcctaatacc aaggtgtacc 3573421 gaaccgtaat catagtcgga atgagctttg gctttttctt tttaggatcc attctgacga 3573481 acaatattac cgtagccatt atttgcattt ccatcggact cgccggaatt tccgcaaccg 3573541 ctccggtcgg ctggtccatc tccgcagaac tcgcgccgat cggttccgta tccatgctga 3573601 gctccatggt gaatctcgca aacaacctgt tcggaggcat tattgctgcg tcactgacag 3573661 ggtatttgtt tgatgtgaca ggctccttta ccctcagctt tctggtagct ggttttgtgc 3573721 tgttgctggg attggttttt tatgtgtttg tattagggga tgtaaaacga attaaactat 3573781 agaacatgaa aaagagagct gccagttggc agctctccct ttacatcaaa gaatcggccc 3573841 gtccccattt accttctcct cgtcctgttc ctctatatca agccccgaag ctagcatttc 3573901 ctgctctatc tgttcgagca cctgctcgtt ttttccttga agaccacctt cataatgaaa 3573961 agcatcctgt gtgccgtttt cctctattgt cgctaaaata tcgtggatat cattatggtc 3574021 tcctgaaatg gagccgaatc cctggttttg ttttttataa ttcacaaaac cgctggggag 3574081 gttgtttccg aggtttacac atgatgcgct ccgagtagta attcatcagt gtatcaaaat 3574141 cttcattttg gattgccaca tcacatgcag agatgatgtc tttcaattgc tgttccaaat 3574201 gaattcccct aatcatcatg attggatata ttatacaatg tttgacacgt agggatcctt 3574261 ttcatttttg tttttacggt ttcgctggtc catttccgca gagctggcgc cgatcggttc 3574321 cgtatccatg ctgagctcca tggtaaatct ggcaaacaac ctgttcgaag gcattattgc 3574381 ggcttcattg acggggtatt ttgtttgatg tgacaaggct cctttacgct cagctttctg 3574441 gtagccagtt ttgttctgct gcttggattg gttttttacg tgtttgtctt aggggatgta 3574501 aaacgaatta agcgggaata aagagtgctt gtagagaaaa cgttgttctt tctacaagct 3574561 ttttagtttt gtgctgtttt tcaagatatt cagctgtcat aaaaagaaaa tgagctccca 3574621 cataccggct aggtatgtgg cgttcttctt catgttctgg catgcagctg tgaggaggat 3574681 ttgtttgctc accccctgaa cctgcgatag ctaagcccgt gcagttgttt tgaacctaca 3574741 aagcttcgtt ctattttttc ttttcttttt ttagagattt cctgaaatag aaaagcaatc 3574801 ttttctaacc ttttctttat ggttttgcca tacataccga gtaacgactt tctggcgttt 3574861 cgttgatttt gtgtaatatt ctcaaacata tttcaggatt tgatttatat gaccgatagt 3574921 ctttgcgatc aattgttgag tacgtaagtg tatgctgatt caacaaatgt atctgtattg 3574981 ttcactttat aatgaaattt ccattttgga agcaaacccc tgactgggtg ataacgtcta 3575041 tgtgcgatgg caccaaaaac ttggaggtca aatagtcctt tagagatgag agttgttaag 3575101 tagccggaat ctagagcgac ggcttctact tgaaaatcaa atcatgcaat ttagtgatcc 3575161 aatcggtcaa ggtagggctt ggaacagaat catggacttt tctggagttg caaactatta 3575221 atcgtcctca ttaaatttat aataaaaata ttctcaattg agcaaatcgc ccaccctttt 3575281 tcctttataa cataaaatcc aatactatca ataaaattct ttacaggtta ttacagttaa 3575341 gatataatat agttaatctt ttacgtaaaa ggaggttttt attacttgtg ttgaagtttt 3575401 aaataggagt aactccatct ccccattacg gtcttcattt aatttcatcc tgagttttat 3575461 ttagttagat ataaaaacga aaatttcaca ttatttttaa ctaaccgata gtataaaata 3575521 tatattgaaa ggattgtaaa attatgaata aattcctgaa gagcaatttc cgtttccttc 3575581 ttgcggctgc tttaggcata tcattacttg ctagtagtaa ttttataaaa gccagcaatg 3575641 ataactataa attccattta cttgtacctt atggctatgg taatgcctat tcaaatgatg 3575701 catttagaca gaccactcat acagataatc cttggaaagt aaatttacag aaatcggcag 3575761 aaggtaaagg tacaatcatg acattttggt tgattaacac agggaatagt aaaattccaa 3575821 aagcttctaa aatacataac gtaaaacaag gaagcggagc tcattattat catgcaaata 3575881 gccagggaag ccatacatat gtagccttag cagttgaaaa caacaattac agtgcaagtt 3575941 cttatggtat agatggtgta tgggatgaag aaacttggta aacaagaacc ttctaaaaac 3576001 gttggcacct tttagccacg cgaaaaaatt tagaatgata atctttttat aagattatca 3576061 tttttattta ttctattaag aattgagtga gaacatggaa agtcatattt atcgcattat 3576121 caaaaataaa ttaactataa taatatttac tataatcata ttaattcctt gtgttgatat 3576181 atcactattg ttaatgacta acacagaata ccatcctgca tatgcgtttt tcctttctgg 3576241 cacttccgta gggcatgctt cacaaatgat cctattatgg tttcttccgc tttatttttt 3576301 gttactatgt gctgacgatt ctatacaaga ttataaaaca ggatatcatt acattcttat 3576361 aagcaaagtt ggcagaaaaa aatattgttt ggaaaaaata tttacctctt ttatcatttc 3576421 atttttgaca atgtttttgt cactaatatt aaacttttta ttggttcagg ttttcttttt 3576481 taaaggtaca tttaaaaatg acttagacca aattaaattc cctgataaca gcctttatac 3576541 ttttagtatg gcccatcctt atatagcaat tgtgttattt tctattattt gttgtattat 3576601 gtctggattt gttggagcac ttggttcaag cctcagttta ctttttcgtg ataagaagta 3576661 tgcctaccca gcaagttttt ttatttggtt cgtacttata ctaaaaaaca aatcattaat 3576721 gtttttattc caaccgttta cagaatacgg ttataatgta cttctcccta tcctatgttt 3576781 gtctatcttt atttttctaa taataatttc tagtattgtt ttatatgagg caaaatacaa 3576841 tgaaaattaa aagactacta ttaattttat gtttactact atttttagtt actttatggt 3576901 tcaaccagaa ccacacttat cttggaaaga attctatcgc gtcattacta tatatgaata 3576961 atagtacatt cggatatagt tcaatatttg catatacctt gttttatatt gtcccgtttc 3577021 ttatgttact tagtaacttt tttcattcag aaaaccccta caaagtaatg aggatggtta 3577081 agcgtaaaaa ttactacaag tctaaaatta tggagattgg gtttgtttct ttactttttt 3577141 cttcaataca tactgttatt aatattacgt gtacacatat tttctttagt aaaaacttgt 3577201 tggtcgaagc aaacttttta tcaatttgtt tattaaacat gattagttta gtgtttttct 3577261 acttatcagt aggtattatg tttagactta catacgatct gtttaattca gtagcattag 3577321 caatttttat tgtgtatata attttagata gcttgtattt cggcgttaaa ttattacttc 3577381 ctaatggata ttgggaaccc tttagagact tggctatatt cacaaatatg ctcaatagat 3577441 attggtcaac ttcaaatctt ataatagttt atattagaca gataataata gtttttattt 3577501 tttatttagt tggatcttca atttttttga ataaggatta taaaaaatga ggattaaagg 3577561 ctttttcata actttagttg cgataatatt tcaggcgtca ttatcgagtt ataataataa 3577621 taaaaatgtc tttccttttt tagatggcat accaataagc acctcgggtc attatgagta 3577681 tcaaaatatt ttattgtggt ttgtacctat tgtttcccta agtttttgtt tctctgggag 3577741 tattagagat acatacattt cgtatgagca attaaagtta gtaagagaac atagtagagt 3577801 taaatgggta acatctcaat tcttaataat tacagttgta cttttaatct ttactttatc 3577861 tcagattgct atattttata tttattcact tgtatctctt cataaccttg atattaattc 3577921 cgttatcaat aaaagatttg ttatgatgac actcatgtat tatctaacct tacttaactt 3577981 atttagtttt caattattta tggagcttta ttataaatct caaatagcac aattaaatat 3578041 aagcgtttat attatttttt cgttaatttt agcaaagaag ttagtgcaat taaattctcc 3578101 gaaagttatt cactactttt taattccaaa ctacagtaat ggattaagaa ctgggttaag 3578161 ctattattcc caatctggaa ctgctattat tgaaccatta ttaggtttgt ttattataat 3578221 cattttacag atttcaatag ttatattatc tgtcttaaag ttcaaaaaaa tagatatgct 3578281 aaaaagtgag ggcttacaat gattgaggta ttaaacctaa caaaaaaatt aaaaagacta 3578341 cagttttaga taatatctct tatacatttg aaaaaggaac aatttatgga ctatttggga 3578401 gtaatggttc tggaaagacc atgctacttc gtgcattatc cgggttaata gtccctactg 3578461 aagggagtat aactattaaa ggtgaacaat tacataaaga tatctctttt cctaaaagtg 3578521 taggattaat tatagaaaat atgcagttac ttcctcagta tgatgctttt actaacctta 3578581 aaattttgtc aaaaattaaa aagatcgcat cagataatga tatattagat tctattagta 3578641 gagttggttt ggaaaatttt aatagtgtaa aggttagtaa attctcgtta ggaatgaaac 3578701 aacgattaaa tattgcacag gctatttttg aaaaacctga tatattgcta cttgatgaac 3578761 caacaaatgc gattgatgaa aaaggagttg catttgttca tgacattctt ttacaagaga 3578821 aaaaaagggg agctaccatt attattacta gtcatcacaa ggaagatatt atatctttat 3578881 gtgacattgc attagaaatg aatcatggac gtctagaaac ttcagaaaaa gtaatatata 3578941 agaaagatag ttagtttaaa ctggctattt cttatccaat gatagactgc agacaagttc 3579001 aactgctgta atgctagaaa atccaatgaa atgctgataa ttgcgaagag atatgatcag 3579061 tcagaaaaca aatcttaaaa agaaaaagta aattcatcaa tatttctaat aaacctggca 3579121 aacaacctgt tcggaggcat tatagctact tcactgacgg gatatttatt tgatgtgaca 3579181 ggctccttac gctcagcttt ctggtgccgg ttttgtgttg ttgctgggat tggtttttta 3579241 tgtgtttgta ttaggggatg taaaacgaat taaactggaa taaagagtgc ttgctgaaaa 3579301 gcactctttt tctgcatcga aagaatactt aagataagtc actcccaaaa atcgtaacag 3579361 tctgacggtt aaacataaac ctctgcccgt tccattttaa tacggtttga acatatccca 3579421 atgagtcggc gttatacctt cccgctatcc gctggtacgc caataattcg tatacgccgt 3579481 ctctgtcaaa atcaaccgga tacaagcccg ataaaggatt cacccatcct tctatcggca 3579541 tttttaacac accttggctg ttataaatct cattcaaata ttccctgccc ttgtaagtaa 3579601 ggtcgaggat atacgtttcg ttttgctgat gactgataac gctcgcttta tattgatttt 3579661 gatacctcac actgtacttt aattcatcat tcaatacatc tgaattgaaa attcgccgga 3579721 actgcctgtt tagataggca aacacatatg cataaatagc accgccgctt ccccctgtgt 3579781 ccattactac tgccacatcc tcaatcttgt cgcctgtcat atcccccaga aaaagtgacg 3579841 gattgtatcc catattgttt tgaagctgaa tccgctgctc ctgatgggtt ctgccatcac 3579901 ggatcaccaa tgtgatattt ctccataacg ggctgccggg catttgattt ccagttagaa 3579961 agacctcgtc aataacgccg tctcccgtta catcgccgcg ggtagataca atgattgcac 3580021 gtgaggagac aggctgccga aatacgtatg gatgttgaac aagtcctctg ccttcataaa 3580081 accaataagg agccattctg atgtcataca cattcaattg tgtcaccttc cctaatcagc 3580141 tgaatgaatc attatatgca ggaatggcac atcaaagaca tatcttacac accaattaaa 3580201 tccgtaccat atgaattatc aattacacaa agccactcgc cttgcgcatt ctttttaaat 3580261 acataggtcg cccttctttc catcgcatac tcggagtcct ttttatccga atcaagcagt 3580321 gtctgagaaa gaacgagtac cgtgtcacct gcttccaaca ggatcatttt cccttgtgtc 3580381 gggacaatat gatgattgaa atagttcgca atcgtgataa acgctttttt gatttcttcc 3580441 ttgcctcgcg cgatcatgcc cggcttcaca actaaaacgg catcttccga ataataattc 3580501 atcagtgtat caaaatcttc attttggatt gccaaatcac acgcagagat gatgtctttc 3580561 aattgctgtt ccaaatgaat tcccccaatc atcatgattg gatatattat acatcgctag 3580621 accactgaaa ccttgaaaac aaaatgaaaa gtatcctttt ttcctatata atcaaataga 3580681 tatatttaac aaagtaccca agtgaagggg tgaacattat tgtctgcgga agtaacgtta 3580741 catgacaata tacattatga tttaagtgcg gattgccagc actgttttgg cctgtgctgt 3580801 gtcgccttgc cttatgcgaa gtcggcagat tttgcttttg ataaagacgg gggcacgcct 3580861 tgccgcaact tacaatcaaa ctatcaatgt tctatacata aagatctcag agaaaaagga 3580921 tttcgaggct gctctgcata tgaatgcttt ggcgccggcc aaaaagtatc ccaaatcact 3580981 tatgagggaa aggattggcg aaacagcccc gaaacggcca accagatgtt tgacgttttt 3581041 cctatcatgc agcagctgca cgaaatgctc tggtatttac atgaagctct ttctatagat 3581101 atagccaagc cgattcattc tgaactgaga accactttcg aaaaaataga aaggctcacc 3581161 agactcagca aagaacgctt gctgacactg caggtggacg agcatcgagc tgaggtcaat 3581221 gaatggctgt taaaaacaag tgaactggtg cgtgcccaag cccgccatcc aaaactcccg 3581281 aaaaaggtca gccggggaag tgtcctgatc ggcgcgaaac tgaaagggct tgatctgcga 3581341 ggagcaaatc taagaggggc gctgctcata gccgccgatc tgagaaatgc cgatttgaga 3581401 atgacagact ttatcggtgc agatatgaga gacgctgatc tcagcggcgc cgacctgacc 3581461 gggagcatct ttttgacaca ggcacaggtg aacgccgcca acggcgattc gaatacaaag 3581521 ctgccgctgt ctgtacgaac ccctgcccat tggaaataaa aaaggacccg ctaacggtcc 3581581 ttttttactg atcaattcaa tcctttttcg ttcctcttat ccggcatttt cacacttctt 3581641 gccaagtatc ccgacagcca taacgcaacc agcagcatga aggtgatcat accgacgacg 3581701 cccagccagt gaaaaccaga ccagaatagc cctccgattg ttccgaaaac acttgaaccg 3581761 gcgtaataaa agaacaaata cagcgatgaa gcctgtgctt tgttgtgaag ggctctcctg 3581821 cccacccagc tgctggcaac tgaatgccct ccgaaaaaac cgaatgtaaa gagggcaatc 3581881 cccagaattt tcactgccag catattgttt atcgtaaata acgcacctgc aatgacgatg 3581941 aaaatattca tcaccaatat tttcggatag ccataccgat caaccattct tccaatgaaa 3582001 gacgagctga aaatgcctac aatcatcaca ataaagatcc agctggaaaa tgctttatta 3582061 agcgaatacg gcgggcccaa cagcacatac acaatgtaat taaacaaggc aacattgctt 3582121 ccaagcagca aaaaaccaat gagaaacaag ctgaatagtt tacggtccct caagtggccg 3582181 atcagagaca ttcccaattt cccgagcttc aattttcttg gcgtaaaatg cctggatggc 3582241 ggcaaattta taaaaaatat aacactagca atcaaactaa tgacaccaat tgtccccatc 3582301 gccatatgcc aattcaagta ctcgctcagg agcccggaaa cgatccttcc gaaaacggcg 3582361 ccgattgcat ttccgctgat atatagcccc atcgctgatc caagacttcc gggttcaatt 3582421 tcttccccaa gataagccat cgcaatcgac ggaaggcctg cgagcgcaac gccttgaatg 3582481 gttctcaata cgagcagtgt atgaaagctc ggactaaagg ccgatgccag acagagaacc 3582541 gatgcggcca gcatggaaat acccataata ggcttgcgtc cccacacctc ggataatgaa 3582601 ccaaagacaa gcatgctcac agctaacagc attgtggtaa cagataaaga aagactcgcc 3582661 gcagtaggcg ttacatgaaa ttcccgcgtg aattcctcca tgagcggctg tacgcaatat 3582721 agaatcgcaa atgtattgaa acccgcagcg aagaaagcaa acgtaatttt tcgaaaaacc 3582781 ggtgtgcctt ttcgaatgta tgtcatcggg actttatcgg tccctcatca tgttgtggag 3582841 cactgccatt cataaacaat catcctttat ttcttacgaa ttcaaacatc ctcgagtctg 3582901 tttatattat tatcttagca ccgttgatat atgttgtata atgcatataa aatatccttt 3582961 tcatgcttat atgtaataag gagagatgat aattggaatg ggaacaactt gaatattttc 3583021 aaacactggc ccggatgcag cacgtcacga aagccgcaaa aagcctctcc atcacacagc 3583081 ctgcactttc acgctctatc gccaggctgg aaaatcattt gggcgtcccg ctatttgaca 3583141 ggcaaggacg atccatcagc ttaaatcaat acggacacat ttttttacga cgggttcagg 3583201 cgatgatgaa ggagtatacc gaaggaaaag aagaaatcca agccttatta aagccagacc 3583261 aaggcgtagt ctctctcggt tttttacata cattaggcac cacgctcgtg cccgatctca 3583321 tcggctcctt tcagcaggaa taccccaaca tttccttcca gctgaagcaa aaccactctt 3583381 attggctgct tgaacgatta aaatccggag atctggacct ctgtctcctc gcttcgatta 3583441 agcctgaaaa tccgatccaa tggatcaagc tgtggagtga agaactcttt gtatttgtgc 3583501 caaatgatca cccattagcc agtcgcgaaa gcattaccct gaatgagatt gccggggagc 3583561 gttttatttt attgaaaaag ggctatgcgc ttcggatgac ggtcgatgag ctgtttgaga 3583621 aggccaatat acagccgaac attatgtttg aaggagaaga agcaactact gccgcaggtt 3583681 ttgtggcagc cggtctgggc atatctattc tcccagacct gaaaggctta gaccaaagca 3583741 aaatcaccaa aatccgcgtc agctggccgg aatgtcagcg tgtcatagga attgcctgga 3583801 taaaaggcag gtttttatca ccggttgctg agacctttaa acaatatgtg atcagccatt 3583861 tttctgagta ggaaggattc aagcatgaat gtcaaaaaaa tcacgtcaga acaggattta 3583921 catacagcgt ttgaaatcag aaaggcagta tttgtagagg aacaaggctg tcccatttcg 3583981 gatgaattcg atgagttcga tacactccac ggtgactgcc agcacatcct ggcttatcat 3584041 cagaatgtac ctgttggcac tgcacgtgtc cgtatcgttg gccacacggg gaaactggaa 3584101 cgaatctgca ttctgaagtc ttaccgcaaa ttcggtttgg gaaaagtgat cgtcgatgca 3584161 ttagaacgta ttgtaaaaga acaaggcatt tctgccttca aactgcacgg ccagacacag 3584221 gcggcaggct tttatgaaaa gctcggctat cggactgcat cagaagaatt tatgctggac 3584281 ggcattccgc atgtgctgat gacaaaacaa gacgattctg cgctatagat tgttcacaaa 3584341 tttgtcactt atgagcatga acggttcatt ggtatactaa tcaccgatta tggagagaag 3584401 gaatgattgt atgccagcaa ataaaaaaga aggccttata tttggcgtga tgatgtgctt 3584461 tggaatggtt tgcgtcatgt cgatttacaa tgccatcatc aaccgagcca tctacgattt 3584521 ttcactgatg accgtttttg aaatggtcat cggttttatg atcgccctcc tgttagattt 3584581 actgttagtg ggccccctcg ccaagaagat tgcattccgc atgccgttcg acaagactaa 3584641 aaaaatttat gtcatccttg ccatgtcaac ttgtatggtg attggcatgg tactttgtat 3584701 gtctgtgttc ggtttagtga cagcggttct agcaaatggg ctgaacgggg acagcctctt 3584761 cagtgcttat cttatgattg tgttgaaaaa tttcatcctg gcctatccgt tgcaattact 3584821 gattatgggc ccattagtca gaggagtttt catgaaattt gtaaaaccaa agctcacagc 3584881 cgcaatttaa atagaaaagg agtgagcctg acactcactc cttttgctca tgaatcgaat 3584941 gtaaaacaag ctccgcaaaa gcctctgcgg caggcagctg ccattttttc tttttgggtg 3585001 tgagtaaatc ggatcgaggg cttcaccatg ctggagattt ttcagcttat gtttttcact 3585061 tccattaatc cctatacctt accacatagt ttttatacaa ttcttcgtta taaaggattt 3585121 cttcgccatg tgaagagcaa atgagcgttg gtttgatttg atctatgatt gagccgctgt 3585181 cgatgttctc atttatatca acactgaatc ttcttatagg tgggtgtaaa tcctccttac 3585241 ttgtgataaa aaggtcgccc gtcaatagcg tacgatcgat tttatgataa tacacaacat 3585301 gccccggcga atggccaggt gttaaatagt atttcagagg cagatgagca agcgtttgct 3585361 ccgtcagcgg ctgtacaata tgggctaccc ctgtgttctc cacttcattt ttgttcggat 3585421 atggctcttc cccattgatg tactttagtt ctttctggtg cgcaaaaatc ggaatatcaa 3585481 atctctctaa ccattttgat gcacccccga tatgatcact gtggccatgg gtaagcaaaa 3585541 tggcttttgg attgccgatc gctaacgctg ccctaatttg agcatcagca aaacgttcta 3585601 ttcccgtatc aacaatataa acatcatcac catctttgat aaaccaggta tgaaccggaa 3585661 tacgaagagg cacatcaagc tcaaattcac attgaaagac atgttctgat agttgtctca 3585721 aattcacgca aaccatctcc tgtggaaatt ttttgatagt tttaaagaaa acagaagtga 3585781 acggactatt ttcacccacg ctcgagctga ctggattctt gagaggaaac gccgattttc 3585841 gccagcatca gctcaacttg ttaacgttgt ccattaataa tcccttttgt tccccttctt 3585901 cacatattcc caatcacgtt ctatattctt cctcactcta tgaaggagtg cagaaatggt 3585961 ttccttttcc tctgaagtaa aaccggacaa ggccacttcc gtggaatgtt ctccttctct 3586021 tcttaacaat ggatatacct ttttcccttt ctcagtcggg aacagttttt ttattttttt 3586081 attttgctca tccggcagtt tttgaataaa tccctgcatt tccagcttct taatggcccg 3586141 cgcggccgtt gtccggtcca cttttatcat ttccgccaat ttttcttgaa taattcccgg 3586201 attttcgtat atacgcacga gatagagata ctgccctctt gttaagtcta aatctttaaa 3586261 ttcgatgttg cttatggaat ccaacgctct tgctatcatg ccgatctcac gcaaaatatc 3586321 attcattcct aaaacccctc acgtattttt gttgcaatta caacaaaaat gttttaacct 3586381 tactattata agaccacatg cgtgctgtac agtccagact aatatcagaa aaggattgat 3586441 tcataatgaa tataaaaaga ataacaactg aagctgattt acatgaagct ttaaagatta 3586501 gaagaggcgt tttcattgag gagcaacatg tgtctgaagc cgatgagttc gatgaatttg 3586561 atacgcttca ggaacaatgc cagcatatct tggtatatca tgagaatcag cctgtcggca 3586621 ccggacgcgc gcgcatcgtt ggccatacag caaagctgga aagaatctgc atcctaaaac 3586681 cttaccgtaa gtacggattg gggaagatca tcgtaagcgg gttagaggaa atcatgaaag 3586741 aaaaaggact gacttcatat aagctgcatg gtcaaacaca agcggcaggc ttttatcaaa 3586801 aactgggcta ccagatttct tcacaggaat ttatggagga cggcatccct cacgtcttga 3586861 tgacaaaaga aatatcgcgg aatataacat gaaatatatg tattacggaa taggcatact 3586921 catattaagt ttgggcattt ccttaaccat acaatcagga ctgggcacat cacccttcga 3586981 tgcccttttg gttggtctgt caaaaaaaat cggtcttacc gtaggaagct gggaggtcct 3587041 tatttctgtg atcctcttaa tctgcaacgc tatattaacg agaaaaaaac ctattttgct 3587101 gggcttgatt acagcattca ttactggaat aggcattgac ctatggttgt ttgttgtaaa 3587161 aaacaccatc tatctaaact cgttgttaag caaactgatt tgttttggaa ttggtttggt 3587221 gctcatcggt cttggaacag ccatctatct tcagacgaaa ttcgcatcaa caccgatcga 3587281 tcatttaaca cttattatcc gagatctctc caaaagaaca atattgtttt caaggacatt 3587341 ggtatacgct cttttcttag tattagccat catctttaaa ggccctatcg gcatcggaac 3587401 tcttttaacg gtttgtttgg gaggaatgct ccttcacgtt tttatgccta ttgtggaaag 3587461 acatttctta tcaaagaata gaagaggtta ttaagaaacc tcttctcgat ccaaaaaacg 3587521 aaacgcaaaa caagccccgt ttcgttgtca attctttatc tctggtactg ttgaggtttt 3587581 ataatcaatt aaaatttata gtaccaaaaa atcgcaattt catttgctgt tggaaagttg 3587641 gaataaagca tcgtatcaac cgcacctatt ataaagtgat gtttggcata aaaatgacaa 3587701 gctgaaatat taatatcttg ggtttcaagc ataagaccac aaaaatgatt ctcctttgcc 3587761 cactcaatcg ctttatgtaa taatgctgtt ccaacacctt tttttctata gtcttttgcc 3587821 acggcaatgt cctctattag tgcataccca ttccagttag aacggatctt aatccggcca 3587881 atgcagttgt tttcaagata atataaaaaa gccgctttcc cctcttcttc aacataacta 3587941 acatccatgt catcatcttc atattgttta aaataaggtt tagaaaatcg ttcctcagta 3588001 tatgtccaaa caccgttttc aaaagcaggt atcattctcc caaaaacaac gaaaggttcg 3588061 tttggtttat tgaaatcttt catattcaaa tgagtcattt tcatgatcat atcaatctcc 3588121 gccaatcgag ataatattta gtaaactcgt ttcgatacta ttcaacaaca gcttccaaaa 3588181 gtgtactctt taagagaaca gcattagata aggcatccat taccttatat atttcactat 3588241 cttaatgagg tatttcaaca gaggcttgtg gtacagtaaa aaggaataga aacaagagaa 3588301 aagaagatga acctatgccc actaacaata aactcaatga gaaatatcat acttccttca 3588361 actcgcccac aaccctgttg actagtatcc gtggagagag gaagctttga cacagcttct 3588421 gccattgatg acatctctat tgaagtatcc aaaggacaac caaggatcgc tctttgactt 3588481 tttcaagaag aaagtagagt gaataaagga gtgattgagt atgttaacaa gagaagatat 3588541 ctttaaacac gtcaaagaaa aatacggtac atcgcctgat tacccgtggg agaaataccc 3588601 aaactatgct tctttgagac atacatcaaa caaaaaatgg tacggtctta tcatgaatgt 3588661 tctcccagaa aaattaggct tggatggtca tggcgaaata gatattctaa atctaaaatg 3588721 tccccctgaa ataagtgatc gcttaagaaa cggggaaaat atcttacccg gatatcatat 3588781 ggataaggaa cattggattt caattgtttt agaacggaca gatccagaag gcgaaatcta 3588841 taacttaatc gagcagagct ttcatttaac caagtgaaga taaagagtgt tcctgctaat 3588901 caagctgcga agagtagtgg gcactttcat tttaggatac tgttcttcac tctgtccaca 3588961 aacgcaactt agttcatctg gtgcgagagt gggagaagaa tttcaaccaa cttcttatgt 3589021 aaaaggatga atagttatga caaataactt aaaacagaga agaatcattt tagatttagc 3589081 agttacttta gatggtttta ttgaagggaa aaatggagaa gttgattggt gtattatgga 3589141 ccctgatatg gggtttactg attttttaaa tcaaattgat actattttat atggtagaaa 3589201 aagcttcgat ttatggggac aatacattcc aaaaaatgaa gaccctgata cagaaaagga 3589261 actttggaaa ttggttcata gtaaaaagaa atatgttttt tccagaacac aaaatgagat 3589321 tgataatcaa gccatattta taaatgataa tattcttgaa gaagtaaata aattgaagaa 3589381 aaatcctggt aaagacatct ggctatatgg tggagcgagt ctcattacaa cttttataaa 3589441 tttggggctt gttgatgaat ttagattatc tattcaccct gttgttttgg gagaaggaaa 3589501 accgttgttt attgatgtaa aacagaggat aaatttaaaa atggtgaata caagaacatt 3589561 ttcctctggc gttgtgcaaa tcgtttatca ttggaatggc taacattgta aagtaacact 3589621 cgacagtaat ccttcttatt gaactaaagg ggaatccata aataatgggt tccccttaat 3589681 atactatgga attatcaata tcaaattttc tgtaataaaa gaggattgaa aaggacgatg 3589741 tctcctcaat taacatcatt aagcattata gtatattttc ttctccctct tttaagtaat 3589801 cggctaagtt ttgtatttat aaaaaaacga aagaaggtga tccaatgcct actaacaata 3589861 aacccaatag attaatcgct gagaaatcta cttattttac ttcaacatgc tcataaccct 3589921 gtggactggt tcccttgggg agaagaagca tatgaaaaag cgaaacgcga aaacaagcct 3589981 gttctcgtat ctattgggta tagctaacga tggctaatct aaagaacatg ctattgatgc 3590041 catgtttatt cattttacaa aaaaggatca accttgaatt actttcacaa gattgatcct 3590101 ttcactcatt tagccatgtc tccgcgaacg tttatataca ttcaagatta ctagccaaca 3590161 aataacaatg attcctgcaa aaagtatgag catattgcta tacaaatagg tagagtgatc 3590221 aacgtcaata ggcagcagcc tatgatctag gaagccgata gataataaac cgcctacaat 3590281 cgcaataccc gttccctctg ataaaaagct cgtgaaatta agcaaactca ttccagcgcc 3590341 cgcttccttt tctttcaaac tgctagacac aactgtagat ataactgttt ttgtgaaaga 3590401 tagcccccca aaaacaaaaa ttactataat tgtcatgatc catggtgctg catctataaa 3590461 aaaggcagcg attaaaaagc cggaagaaag caatgcactt ccaatagtta gtacatacaa 3590521 ggaacctttc cgatcaacaa gcaatccccc aatgtaacca aagatgatga cactcattgt 3590581 tccggggaaa ataatgccgc ttccaattgc tgcagtactt aaatggtgaa catctttcat 3590641 catgtaagga accatagaga caaatcctgc tactgtacca aatattagtc ctccgcaaag 3590701 ggttccaatc acaaaaaaga cgtttttccc taattcaggg tcaacaaaag ggtcctgagc 3590761 tttcctaatg tgttgcacaa atatgaagaa agcaaggata ctgatgatca gaaaagaaaa 3590821 tctataagat gttgtaaaca gcataaaaaa tacgatacct gcagacatca atataatccc 3590881 tgccatatca atgtgtcctc ttattctctc ttcctttttc aacaatttta taaggaatgg 3590941 aacggtgata attgttgcag ttggaataag cagcaaatac gaccaatgga tataatgagc 3591001 aaccattccg ccaatagctg gcccaacacc ttctcccatt gctaccaggg acccgatcag 3591061 gccaaatgct ttccccctgt tctcttttgg aatatagcgc gcaacgacaa ccatcacaag 3591121 agctgggaat gcggctgcac caattccttg aataaatcgg gctagaatga gaataggaaa 3591181 gaaagagtgt ccaacaaatc caatgatcga ccctaagcca tttaccataa tcccaaatag 3591241 aagcagattt ttgatgccca gctggtctga tagctttcca tatagagctg ttccaatgga 3591301 gaaggttaac ataaaggctg tattcaccca gtttgcactt gctggcagtt tattaaactc 3591361 gttggcaata tcaggtaatg agacgttcag aaccatttca tttaatacgc tgaaaaatga 3591421 tagaacacaa agccaaatca aaacttgatt gtgccgtaaa gttgactgtg aataagacgt 3591481 attcacaatt tcccctccat taatgagggc agacgcagtt tatagggtca ttgatacgct 3591541 tccctctttt aattgtaccc tgttcatttt attgcacttc ataataactc cccctacatt 3591601 tgattgatat gatcttatta tatatagact aaggattaaa cttttacttt ttttataaaa 3591661 atttgaccag attgcgaaac aaggaaaaac gttattcgca tttatctcaa gtggcaaaat 3591721 gaaacattag tttatatttt cacatcacaa ttatcgataa gcagtcagtt attgtatttg 3591781 tttaggataa ctgtggtaac ctgaatataa ccaacttagg aagaaggtga tcccatgcca 3591841 aataaaagta aacccaatag attaatcgct gaaaagtctc cttatttact ccaacacgcc 3591901 cacaaccctg tggactggtt cccgtgggga gaagaagcat ttgcaaaagc aaaacgcgaa 3591961 aacaagccgg ttctggtcag catcggttat tcgacgactt gtcattggtg gcctgggata 3592021 atcaaatcgt gtggaactcc attaaaagat aacagaagcc attttaaacg ataatactat 3592081 ttgttcaaac aatacagtct accttttatt tcattcattt tctaaaacct gtaatccgta 3592141 accacgcggt agcaggtttt tttatttgct tgacttagag ttaactctaa attgtaaact 3592201 aactttaatt aaatgagagg gatgatgttg ttgtattcca ttagtaaagc tgctgagaag 3592261 actagtatta gttcgtatac attaagatat tacgaaaaga ttgggttact tccaccacca 3592321 aaacgaaaaa acagtggaag gcgtttttat acggagactg atattcagtt catgttattc 3592381 ctgaaaagtt taaaggaaac aggtatgtct ttggaggata ttaatgagtt tgtcaaagac 3592441 ggatgcattt tggaaaaaat caattcggat gttaaatcgg cacaactctc cccatctata 3592501 aataaacgta ttgagatttt aaccaagcac ttagagaaaa tggaaattaa aaaaagggag 3592561 ctggaagaag tgatttctac tacaaaagga aaactggata catattattc aattttgaaa 3592621 gaggaagtgg aaaacaaatg aaacatttaa atatatacat aatgttactt ggcttctcta 3592681 ttttcacggg agctactttt aatcttgcaa aatatacagt tggatatttt tctccatcgt 3592741 cttctgcggc atggcgtttc ggtttagcgg ctgcagtgat gctcatcatt ttgattttta 3592801 ctgaaggtat aaagaagagt caattacgga aaaacgccgt ttcatacatt gttcttggaa 3592861 ttataggaat ctttggattt aatgccttgt tttttgttgg tttaaaatat acatctcccg 3592921 ttaacggagc attaataatg gggctgaatc ctttattaac agcaattctc gctcgaatta 3592981 tcttaaagga caacatgaca aaaaaacaag tactcggcat attctttgca ttcatcggtg 3593041 tattgttagt cattacacaa ggttctatcg aaaccattaa aaccttatca atttcaggag 3593101 gagacttaat aatctttaca ggtaacgttt gttgggcact ttatggcgta cttggacgtc 3593161 ggtttgtaaa ggatggtaca ccgctatcta caaccactta tacgatggtt attggtgctg 3593221 ttagtttaat agtagtttcc ttatttacat ccaaacctgt ttctttatcg aacatcccga 3593281 ttggagtttg gggggcaatt gcttttatgg ctttttttac aagtgttttg ggttacctat 3593341 ggtggaatca ggggattaaa gagattggag ctagtaaaac atctttattt ttcaaccttg 3593401 ttcccgttgt aacgatgatt atttcatttg ccgttggaac accaataaag gtatttcaag 3593461 ttattggggc tgtgctagtt atattaggcg ttttaaccgc ttcgggggta atacgtattc 3593521 ctaagtacaa tactaaagaa cagtcagcta tataaagaaa tagggagtat ttttgagaaa 3593581 atgtgttaag ttaaatatac actaattata ggaagaaggt gatcccatgc caaacaaaag 3593641 taaacccaat agattaatca atgagaaatc accatattta ctccaacacg cccacaaccc 3593701 tgtggactgg ttcccgtggg gagaagaagc ttttgaaaaa gcaaaacgcg aaaacaagcc 3593761 ggttctggtc agcatcggtt attcgacttg tcattggtgc cacgtgatgg cccacgaaag 3593821 ctttgaagac gaagaaatcg cgcgtcttct caatgaacgg tttgtggcga ttaaagtcga 3593881 ccgggaagag cggcctgatg tggattctgt ttatatgaga atctgccagc tgatgaccgg 3593941 gcagggcggc tggccgctga atgtgtttat cacgcctgat caaaagccgt tttacgcggg 3594001 tacatatttt ccaaagacga gcaaattcaa tcgtcccggt tttgttgatg tgcttgagca 3594061 tctgtctgag acgtttgcga acgaccgcga gcatgtcgag gatattgcgg agaacgccgc 3594121 taaacatttg cagaccaaaa cagctgcaaa aactggtgag ggccttagcg aatcagcgat 3594181 tcaccggaca ttccagcagc ttgccagcgg gtttgacacg atctacggcg gtttcgggca 3594241 ggcaccgaaa tttccaatgc ctcatatgct gatgtatttg ctacgttatg atcacaatac 3594301 agggcaggag aacgctctat acaacgtgac gaaaacattg gacagcatgg cgaatggcgg 3594361 catttacgat catatcggct atgggttcgc ccgctattcg accgatgacg agtggctcgt 3594421 tccccacttt gaaaaaatgc tgtacgacaa tgcgctgctg ctgaccgctt atacagaagc 3594481 ctatcaggtc acgcaaaaca gccgctataa agagatttgt gagcagatca ttacgttcat 3594541 tcagagggaa atgactcatg aagacggaag ctttttctcg gctttggacg cggacacaga 3594601 aggagaagaa ggaaagtact acgtgtggtc aaaggaagag attctaaaaa cgctcgggga 3594661 cgatctcgga acgctgtatt gccaagtgta tgacatcact gaagaaggaa actttgaagg 3594721 caaaaatatt cctaacctca ttcacacaaa gcgagaacaa atcaaagagg atgccgggtt 3594781 aaccgaaaaa gagctcagtc tcaaactcga agacgcaaga cagcagctct tgaagacacg 3594841 cgaggaaaga acctatccgc atgtcgatga taaagtgctt acctcatgga acgcgctgat 3594901 gatcgcgggt cttgcgaaag cggcaaaggt ataccaggag ccgaaatatc tcagcctagc 3594961 gaaagacgcc atcacattta ttgaaaacaa attaatcatc gacggccgtg tgatggtccg 3595021 atatcgtgat ggcgaagtga aaaacaaagg ctttatcgac gattacgctt ttctcctatg 3595081 ggcttatctg gatctctatg aagcttcgtt tgatctttct tatttacaaa aagcgaagaa 3595141 actgacagac gatatgatca gcttattttg ggatgaggag catggcggat tctacttcac 3595201 cggacacgat gcagaagcct taatcgtacg ggaaaaagaa gtgtacgacg gcgccgtgcc 3595261 ttcaggaaac agtgtggcag ctgttcagct gctgcgtctc gggcaagtca caggcgactt 3595321 atcactgatc gaaaaagcgg aaacaatgtt ttccgtgttc aagccagaca tagaagcgta 3595381 tccgagcggc catgctttct ttatgcaaag tgtgttaagg catctgatgc ctaaaaaaga 3595441 aatcgtgatt tttggcagcg cagacgatcc agccagaaaa caaattatag cggagcttca 3595501 aaaagccttt aagcccaacg actccattct ggtggcagag cagcccgagc aatgcaaaga 3595561 cattgcgcca tttgcagcag actaccgcat catagacggc aaaacaaccg tttatatttg 3595621 tgaaaacttc gcctgccagc aaccgacaac aaatattgaa gaagcgatcc acacattaat 3595681 aagcagcagg gattaagacc cttgctgctt actttttgat ttcttatggt accataaagc 3595741 gatccccgca aacacaaggt tgaccgctat cgtaaagaaa gcctcccaca tcgggttccc 3595801 ccgcgtaacg gtaaacagag aaggaattcc tccatacaca ctgttttttt ctgtaataaa 3595861 catacacaaa aacatattat tcgcggcatg ggcgccaagt gatatttcga tgctcccagt 3595921 tttaatcgtg taatacgtcc acacaaaccc aaatgttaag tactcaattc ctgcccagac 3595981 agcgccattg ttcatttctg gattcgcaaa atgcaatacg ccaaacaatc ctccgacaat 3596041 cagtgtcaaa aatagaggat ttttcgtcaa tctcccgaaa gcttgaagca aaaatcccct 3596101 gaaaaatagt tcctcagctg atgtctgaat cggaaccaaa atgagggcag ccgctagcag 3596161 ccagataaat cgtgatgcat taaactcttg cattgaatag ctatcaggat gaatcacaaa 3596221 atcaatcaat tgtacggcga tcattagcaa gaaataagca ataaaaccaa aggaaattct 3596281 ccgccaattc atctttgaat ttggtgttat caccgttcgg aaaggccgct tcaaaataaa 3596341 gcgcacagcc agccaaactc ccggaatggc gaataaataa atcacatggg acaaataaag 3596401 atctacgagg ggatcactca gcacagcttc atccaaatca aacgtgatat tgggattcac 3596461 aataaccgtg aacaatatag cgaaaaggta agctatattc cctaatacat ataaccctac 3596521 catcaccaaa aaagcgaaaa aatatctcca caacgtattg tttccttcta taggacggat 3596581 aaatgaattc attccttcta tgtctcttcc tttcaatgag aatattacta tatatttgca 3596641 taaattggtc tatgaatcta ctgttttgga aatcttttaa gcaaaattaa aatataaagt 3596701 gtgaatttag ttcttccatc tagtgatttg aactctgttg ccaatgaacc aagatactta 3596761 taatagtccc aagaggggaa ttttcagtct tttctactac tcaaaagggg gttttttatg 3596821 aatacgatct tcaaacaaaa gaatacacat cctttctcaa acgcagcgaa tcgtttagac 3596881 cgccttccga tttcacgcgt tcatttccaa gtgttaaccg ctctcggcat tgtttatttc 3596941 tttgatctcg cagatttatt taccctcagc aacgtagcgc cggcactgat cgagcattgg 3597001 ggcatcccgc tttcaactat tgctaacgta acggccgctt cgtttttagg catgttttta 3597061 ggcgcttcac tgggcggacg gctgtccgat cgaatcggcc gcaaaaaagc cttaaatcta 3597121 tttgtctttg ttttctcaat cgcatcgcta tgcaatgctg cggcatggga cattccatct 3597181 ttaatgacat tccgtttcct caccggattt ggcgttgcag ccgccatggt cattacgaat 3597241 agctatttgg cggaattttt cccttcaagt gtacgtggaa aatatatttc tttttgtgcc 3597301 atgattggat tgattggggt tccgatcacc aacattgtgt ctgcctttgt cattcctctt 3597361 ggttcatggg gatggaggct agtatttgta tggggtgccg tcggccttat ttattttttc 3597421 ttcatccacc gtctggaaga gtcacctcgc tggcacgaaa atcgcgggga atatgcgaaa 3597481 gccgatgcga tcctcacccg aattgaagaa caggttgaaa aggagaaagg cccgcttccg 3597541 gcagcatccc agcctaaagt aagcgaaact gttaagcaga atgcaggtta cgcaggctta 3597601 ttgaaaggca gaaacctcaa aattaccatc gtattatctg ctgtatggat ttttgaaacg 3597661 tttgggtttt acggatttgc ttcatgggtt ccaagcctgc taaaaagcaa tggcgtaacc 3597721 atggaaaata cattatggta taacgtattg cattccgtcg gcgctccact tggcgcactg 3597781 ctcggctcca tgatttccga aagatttcaa agaaaatgga ttttagctgc gagtgcgttt 3597841 ctgacggcca tcgccgggct cttatatggt atgactttta ttcccatcat gatcattgta 3597901 tttggtttta tcgtgaatat cacagaacgg gtctttacct cgaacttata cgcctataca 3597961 tctgaacctt atccgactga ataccgctcg tctggcagcg gtttagccta tggtcttggc 3598021 cgtttttcaa acatttttgg ctcattgctt gtcggattta ttgccgttca gctcggctat 3598081 atcagcgtct tcttatttat tgggggctgt tggctcgcat gctccttgct gttaatcttc 3598141 ttcggtccta atacgaatgc aaaacagatt taaaaaagtc agtgcggatc tgccgcactg 3598201 atctcattac aattgcttca aaatccttgc ggggtttccg cctacaacag tattagcggg 3598261 tacatcctta gtgacaacag atccagaagc aatcactgcg ttatcaccga ttgtcactcc 3598321 cgggttaatc accgcccggc ctccaatcca aacttgatct ccaattgtca caggcttacc 3598381 gaactccttc ccggatttcc tttcgatcgg atcaagagga tgaccggccg tgtagatatg 3598441 tacacctggc gcaatcaaac aatgacagcc gatacgcacc tcacacacat ctaaaatgac 3598501 acagtcaaaa ttaacaaatg tatgatctcc gatatgaatg tgatagccat aatcacagcg 3598561 gaatgtcggc aaaatcgtga cttgatcccc aaccgaaccg agcagctcct tcaaaagctt 3598621 cgtccgcact gcatcatctt ccggtgtttc gttgtattgt ctaatcagct gtctcgcatg 3598681 cttgcgttct agtaatagtt gttgatcttc cgaattgtat aattctccgg ctgccatttt 3598741 ttctttttct gtcctcagca tttaagtcac tccagatgtc agattgtaat ctcgatcaaa 3598801 tttccttcat catcctcaat cacgctttca tagtagccgt ctcctgttgt cctcgggccg 3598861 tttactactg cgaaaccatc cgccttcaat cgatcagtca gttcgtcaac tttctcccgg 3598921 ctcccaacgg aaaaggcaat atgtgcccag cctgtcattg tttgtgaggg cggatcggtc 3598981 acattccctt ttttcataat ttccagcctt gctccggaat caaacgtaat aaaataagac 3599041 ttaaaatctt ttttctcatt atgatacaaa tcattcgctt cgccattaaa atacgattca 3599101 taaaaagact tcattcgctc taaatcattg acccagaccg ctgtatgttc aatctgcatt 3599161 tcttcctcct ccttcgcctt caatgaagtt ataaggtatg aaatgcattt cagttcaagc 3599221 ttttttctta aatttatgct gaattttgat atcagcgggt tcatcctgca aaaatagaga 3599281 aaatgctgcg atgccgagct gctcaagatt caaatcaagc gacggaaaac caagaacacg 3599341 gctgatagaa gtatttccct cgcctatgat ttcaacatcc caattattct ttttggcaaa 3599401 tagatgaatt ccagctgcca cttcatcact atttgcataa atagcagtcg gaacccgccc 3599461 gctcatataa aaatgttcag ctgccagctc accatcattc atatcgttgc atccggacag 3599521 catatggcgg tcttccaacc ttccgcagac agctttatag gccgcagctt tatcagccgt 3599581 gctcgggctc ctatcagctt ctctgacaca cgtaaaagca atattctcat gcccgcggct 3599641 ctttaaatag cgaaagctct ctgcataagc agtttttctg tcattaaaag cacaagggac 3599701 atcaatgtct ccggtatcct cacaagcgat gaccggccca tattcctgat aagctaaaat 3599761 gctgtcccaa tgattggcgc gggaagtaat gatgagaccg tctattttct tcgttcttaa 3599821 cagctctaaa tatttgattt caatatcggg gttataattg gtggggagaa gggtcgttgc 3599881 atactcatgc tgaaaagccg ccttggtgat tccgttaacg attttatcaa agcagggatg 3599941 atcgctataa ggcagaatca caccgaccgt atgggttttc ccgcgaatga gatcgattgc 3600001 ggttcgattt ggtgtataat ccaattcctt catgacttga tgaacaagct ttctcttttc 3600061 ttcagataca tacggatgat gattcaatac acgcgagaca gtcgaaacag atacatttgc 3600121 cagtcttgcg atctctttta tatttgccat ctctttctcc ttttcatata aaaaaagcag 3600181 taagtgtaaa atccttactg ctatctcatc atatattgat gataagttca acaggacaat 3600241 ggtcggaacc catgacgtcc gctgatatgc tggcatcttc aatctgttcc ttaaggcttt 3600301 cagaaacaac aaaataatca atccgccatc caatatttct gtcccgggcg ccggcacgat 3600361 acgaccacca ggaataagcg ccttcaagat caggataaac atgacgaaaa gaatcaacaa 3600421 agccagcttc taagaaacga gtgaatgcct ctctttcttg atctgaaaat ccagcgttat 3600481 tccggttcgc ctttggattt ttcaagtcaa tctcctgatg ggctacattc aaatcaccgc 3600541 ataaaatcac tggttttttc tgatccaatt caagaatata agacagtaaa gcctcttccc 3600601 attgcatgcg gtaatcaatc cgctctaatc cccttctgga attgggcgtg taaacagtca 3600661 tcacaaacac gttttcaaat tccagcgtaa tcactctgcc ttcttggtca tgctcttcta 3600721 ctccgatacc gtagatgacc tgcagcggtt cttgcttaga aaaaacagct gtgccggaat 3600781 atcctttttt cactgcataa ttccagtaca catgatagtc ttcaggctgg agatcaacct 3600841 ggccgtcctg tatcttcgtt tcctgaagac atataatatc tgcatcctct tctttcaaat 3600901 aagagaggaa atccattttt ctcatcacag cccgcaggcc gtttacattc catgaaatca 3600961 acttcatgtt tcatcctccc ccctataaaa aagagcaaga acccgaaggt ccttgctctt 3601021 tacatatcag cttactcacc gcttacgtat ggaagtaaag ccatttgacg tgcgcgtttg 3601081 atcgctgcag tcaatttacg ttggtattta gcgtttgttc cagttacacg acgtggtaaa 3601141 attttaccgc gctcagaaac aaacttttta agaagatcta catctttgta gtcgatgtgc 3601201 gtgataccgt tagaagtgaa ataacacact ttacggcgtt tcgcacgacc gcctctgcgt 3601261 cctcctgcca ttgtcatttc cctcctttct ttttcatttt aggcgataat cacattagaa 3601321 tggaagatca tcatccgaga tgtcaatcgg tttgccgtcg ttggcaaatg ggtcatcatt 3601381 aaagctgttc ccctgattgc gtctctggtt gttttgattt cccccaaatg gattatcatt 3601441 ttggcctccg ccaaagtact ggcctccgcc gctgtttcct tcgttgtatc cacctgaacc 3601501 agaaccgccg ccgtttttcg gctcaagaaa ttgaacactt tcagcttgga cctctgtcac 3601561 gaagacacgc tgtccttgct ggttttcata gtttcttgtt tgtaaacggc catctacgcc 3601621 tgcaaggctt ccttttttca agaagtttgc aacgttttcg gcttgtcttc tccaagtgac 3601681 acaattaatg aaatcggcct cacgttctcc ggactggttc gtaaatgtac gattcacagc 3601741 aagagtaaac gtagcaacag ccgcaccgtt tggcgtataa cgaagctctg ggtcttttgt 3601801 cagtcttccg actaatacaa ctcggttaag cataagaaag accacctttt accattatat 3601861 atttcaaaat tgcttattct tcttctttaa caacaatgtg gcgaatgata tcgtcactga 3601921 tcttagctag acggtcaaat tcttgaactg ccgcagcgtc agattgaacg tttacgattt 3601981 ggtagaaacc gtcgcggaaa tcgttgattt cgtaagcaag acgacgttta ccccaatcct 3602041 ttgttccagt gatctccgca ccgttagaag tcagaacgtt gttgaaacgc tcgataactg 3602101 cttttttaga ctcttcgtca atgtttgggc ggataatgta cataacttcg tactttctca 3602161 tctgtttgca cctccttttg gactaagcgg cccataatgg gcaaggagca ataattctat 3602221 tactcacaat tttatattat accaaagctc ttgtcccttt acaactgcat cctatacatt 3602281 aaatcggaaa tgaataacat ctccgtcttg gaccacatat tctttccctt caaggcggac 3602341 ttttcctgcc tctttagctc ctgccatacc gccgcccgca agaagatcct cataagcaac 3602401 tgtctcagca cgaatgaagc cccgctcaaa gtcactatga ataattcctg cacactcagg 3602461 ggctttcatg ccttttttga atgtccaagc tctgacttcc tgttctccgg ctgtgaaata 3602521 tgttgcgagg ccgagaagag agtaagacgc tttgatcagc tgatcaagac ctgattcttg 3602581 aatgcccagc tcttccaaga acatttgctt ttcttcgcct tcaagctcag cgatttcaga 3602641 ttcgattttt gcacacacaa cgataacttc tgcgttttcg ccggcagcgt actcgcgaat 3602701 cttcgctaca ttttcattgc cagatggatc agcaacttca tcttcactta cgttggccac 3602761 gtacaaaata ggcttcgaag tcagtaaatg gagctgcttc acaagctttt gctgctcttc 3602821 agtgaattct acagatcgag caggcttttc actctcaaac gcttctttca gtttagataa 3602881 aatctcaaac tcaaatacag cgtctttatc tttttgcttc gcaagcttgc tgacgcgtgt 3602941 aatccgcttt tcaactgttt ccatatcagc gaggatcagc tcaaggttga tcgtttcaat 3603001 gtcatcaatc ggatcaacct ttccggaaac gtgtgtaatg ttgtcatcgg aaaaagcacg 3603061 gacaacgtgg caaatcgcgt caacttggcg aatatgagat aggaacttgt tgccgagtcc 3603121 ttctccttta gatgcgccct ttacaatccc tgcaatatca gtgaattcaa aagcagtcgg 3603181 cacagtcttc ttcgggttga ccagctcagt cagcttttgc agacgatcat ccggcacctc 3603241 tacaattccc acgttcggat caattgtaca gaacgggtag ttggctgatt cggcaccggc 3603301 ctgtgtaatt gcgttaaata gtgttgattt tccgacgttc ggcaaaccaa caattccagc 3603361 tgttaaagcc attctttcat ctcctctata taaaaccgtc attgtatgaa cgtattttga 3603421 acctagagca attataagga ggttcactgg aaaagacaag ctgacaaaaa agcattttca 3603481 gcttgccaat ccctttgatt atgctttttt caagcctact aaacagtcaa aaagcgtact 3603541 tcccattcca ttatcagaat ttgtatcatt tgtcagtgca ttgactgacc ctccaaaagc 3603601 cgcccacatg ccttcatcta tattaatcgt cttcgcatga gcctgcttca tcactttcac 3603661 cttgcccttc atgcttccgc ggtcattaaa gatgacaact tcgtctccat cctgaagatc 3603721 ctgcccagcc gctatatctg gagaaatatc gacctgaacg tgctgaagct tttcaataaa 3603781 cggcacatgc tgtgaatgat tggaacgctg cggatgaatg gataagagcg tataagggta 3603841 ctttccagct aactcctcat tatggaaaac agattcttcg ggcacattta attgaagcga 3603901 gccgctaaat cctttttgct cagctagcga cgaagtaaat tcaaattttc cactcggcgt 3603961 caaaaactga taatcatccc acggcacctg ttttactgga agagggaggt ggcctttttc 3604021 ttttaaacgc tcaagtgtca catcctctgc ttccaatgaa gaaagcccca tctctaaaaa 3604081 ttcttgagtg ctgtattcaa acagctcgcc aaacccaaga cgttttgcaa gctctgacca 3604141 gatccagctg tccgatttcg cttcaccctg cggctccaca agcttcttcc cgtactgaac 3604201 ataatgatga tacatactgg aatagtagat atcttcttct tcaaaaacag tggcagtcgg 3604261 caaaacataa tcacacagct ctgcggtatc cgtcataatg gaatcaatcg cgaccgtcat 3604321 tggaaccttt tcaaatgctt gtctcacctt atttgtattc ggcacctgag tcagcggatt 3604381 tccgcacgtc acaataatca tctcaatcgc aggatcagca gcggtcaaca cttcttcagc 3604441 ctgtgtcatc attgaaaaag aacgggatgt tgtttttaat tccggcagcg tcagctttgt 3604501 ttttgcaaag ctctcaccaa tctggacatt tccgaaattc gcgccgccgc ccttaattcc 3604561 gacatttccg cttgccgcca caagtgcatc aatccaacga atcgttcccc cgccgttttt 3604621 atatcgctgc atgccaagcc ccataaaagt agacaccgga ccatcagcat acaaacctgc 3604681 caaatactcc agctcctcca tagaagtttc tgttttcaca ataaactctt ccagagaaac 3604741 ggtcttcaaa agctctttca catcatcaaa accgacagaa tgctcagaaa taaacgtttc 3604801 atccgttctt cccatctcaa tcagaacctt caaaacggct gccgcaagcc agccgtccat 3604861 tccaggcttt acagagatat agcggtcggc aagcttagca gtcgggttga agatcggatc 3604921 aatcaccgta atcgtggcgc ccttcttttt cacctgctgc aagtgatggt ataagtgcat 3604981 atttgttctt gatacatttc ttccccacac aacaacatgc ttgctgttgt aaatatcaag 3605041 cggtccgtga ccgtacgaac ggccaaaatc ccagctttgc gcctcgatac cggagcccca 3605101 gcatatgctt ccgacgattt cggtcacgcc gccatatcca ttaaaaaaac gctgatcaag 3605161 cgcttttaac agaccgttat tcgcataatc atggctgtgc aaaacagcag tcgtctccga 3605221 cgtttccttg atttcccgaa gtttatcggc aatttcatca agtgcctgct cccaagaaat 3605281 ccgcacaaac tcgccatttt gttttttcat tggatagcga agccgatcag gcgaatttgt 3605341 ttttgtctca agcattctgc cgcggccgca gattttacct tccgtaatcg gatggtttgg 3605401 atctccgtcc acttttgtta cctttccatc atcaacagtc accaaaaagc cgcagctgtc 3605461 ccaacaattc agcggacatg ccgactgatg cactttgctc atcgccgtct tctccttacc 3605521 ttctatatga aaaagcatga gtgtcggcct atttatgaag taggctcctc atgcttgact 3605581 agtacttttt ttagttttct ttcaaattct cttctcggaa tcataacact gtgagagcat 3605641 ccctcacact taattcgaat atccattccc atgcgtataa ttttccagct gttcgctccg 3605701 catggatgcg gttttttcat ttctacgata tcattcaggc caaagtcttt atccgccaag 3605761 acccttcacc tcttttccta aactgctgta tctattgtac aaaaaaactg atcataagag 3605821 caatcaagat acccgaaaag aaatacatcc tcttatttcc atttactcaa aataggatat 3605881 aagagcagac aaactaacaa atacaaattg agcatcccat atatcggata caagaacgcg 3605941 atcaaatcag aaaatccgaa agaagtaaaa ggtaccatta acactaacaa aatcaacaca 3606001 atcatccatc tcggcatatg aataaacgcc atcagccggc tggacaaacc cagcaaacca 3606061 gctaccgtcg tcgtgtaaat cgccaggcac agcaccgccg tcatacataa aaaaaggaaa 3606121 taaggcgcac cctccagaac ggcaaacagc ggtatttcaa actgagaaag ggagcccgcc 3606181 agctccacca acgtttcatt ataaacaaat gagatcacgc caaaaataag accgcttgcc 3606241 acacttgcga tttttgcttc tccgagccct ttcatctctt tcccaacaga ggataaaatc 3606301 gcaacaactg aaaggatgtt taaagaggta aacgtaatgc tcgcaggcca gttatactgc 3606361 tgggacaaat caatcgtcca cgtatggtga tgtgtgctct gaaaggagat cagcgcatat 3606421 aaaagccccg ctactaacac aggaatcaaa atactattta tagataatat tcctttcaca 3606481 tcccacaaaa acaagcacac tgtcacgatg caaatcagcg tgattcccca ccagaaagga 3606541 agcttgtaca tttgcagggt cacaccgcct ccggcaatca tcaccatagt cgtcgaaaac 3606601 aaataaaaaa tgatgaggac atcataaatt ttcgccagcc atggccccat taaatgctcc 3606661 agaaccggca gaaaatgagt ggattgaacc ttaaaactga ttttcatcac aatataagac 3606721 gagaaaatga acataattgt aaacagcaca atagcaagtc cgctttccgc cccaaaaaac 3606781 tgccatatct cctgaccgct cgcatatccg gccccgatca ggctccctaa tatgagcagc 3606841 atccacttca ttccggctct ccacaacact atcacctcat agacaaagtt cagcttgttc 3606901 ccgttattgt tactatataa ataaaggaaa gcaaacatgc catattttca tagacatttg 3606961 aacacaagct gaaattatca tacgaaatac acataaaaaa gactgctaat acggcagtct 3607021 aaaaagagat atttatttgt ttgtccgcgg aatgaagaag tgaacttcac tcttcacttt 3607081 tttctaacca ttcctaccta ttcaagtgtt tcataagcag accattgctt gatcatgatc 3607141 gaggcaatgg gggacaatac ttgtaatcgc ccactaacca ttcatatcat gccctctact 3607201 tttttaaaat ctctggtgcc atacacaaag cataaaaaat catactgctg gatatactgt 3607261 aaacaacctt acataactac acacaccata gcaattctgt tacctactat aacaaggaag 3607321 tgaaacccat gaatcgaaaa ggcgggcttt tttcttctca ggaacgagta aagcaatatg 3607381 tttcacatac agatgctgca gcggcaaaac aaatccaaac catcctttct tcatccttac 3607441 gtaaagctgc tggcaaacca attgtcgtgg tttgtatcgg aacagaccgt tcaaccggtg 3607501 actcattagg cccgctcgta ggaatgaaac tcaaacagat gcagctcacc agattccatg 3607561 tctacggaac cttatctgac cccgtccatg ctgtgaacat gaaggataaa atcaatgaca 3607621 ttcataaatt acataaaaac ccatttgtta tagcagtcga tgcatgctta ggccgcgtta 3607681 agagtgtggg ttcatttcaa atcggggacg ggccattaaa gcccggagcc ggtgtacaaa 3607741 aagaccttcc tgaagtggga gatcttcata ttaacggaat cgtgaatgtg agcggtttta 3607801 tggaatattt tgtattgcaa aatactagac tcaacttggt catgaatatg gcaaatgttc 3607861 tagcggaagg tttgagttta acagatcgga cagagtggag gcaagaacgc cttaacccgt 3607921 tgcaaaggct cactgggcgc atataaaata aaaaccatct tcgtttgaaa gatggttttt 3607981 tcatttatga ttctcgttca gacaaaagct ctaaaatccg gtcaaggtct tcattagaga 3608041 aaaattcaat ttcgattttg ccttttttct tctgtctttt aatattaact gttgttccaa 3608101 aataattttg gagataggat tcccgttctt ttagaaccgc atctttcaca ggttcttttt 3608161 tctttgtttc acgtggaaca ttctgattca actgctgaat cagctgctca agttggcgaa 3608221 cattgagctg ctccgcaatc actttttgta ccagcggttc aagcttattt ttgtttttta 3608281 agccaagaag cgtgcgtcca tgtcccatag aaagcgtgcc ttcggcaata agctgttgaa 3608341 tattttctgg cagtgtcagc agtcttaaat gattcgcaat atgcggtctg cttttcccaa 3608401 gacgtttggc aagctgctct tgtgtgagat ctaagtgttt caaaagggag tcatatgcct 3608461 gagcctcttc aagcggagat aaatcttcac gctgaaggtt ttctaataaa gcaatttccc 3608521 tcattaacgc ctctgataat tcacggacaa tggccggaac tgtatctaaa cctgccagct 3608581 ttgccgctcg aaaacgccgt tcacccgcaa caatatcata gccttttaaa gattttctga 3608641 cgataagcgg ctgaagaatg ccatgctgca gcacagattc ttttagttca gctaatgcct 3608701 cgtcatcaaa gtgttttctt ggctgataag gattagggcg taaatcggca attttaattt 3608761 cttcaactgt ctcttcagac aaatctacct gattaaataa cgcattaatc ccttttccaa 3608821 ggcctttagc cattcgcagc cacttccttt gctaaatcta aatatacttc cgcacctctt 3608881 gaccgcggat cgtataaaat gatgggtttt ccgtgactcg gtgcctcact cagacggaca 3608941 ttacgcggaa taactgtctt atatacttta tccctaaaat actttttaac ctcttcaatc 3609001 acttgaatgc caaggtttgt ccgggcatca agcattgtca gcaatacacc ttcaatcatt 3609061 aaatcagtat tcaaatgctt ttgcacaaga cgtactgtat ttaataactg gctgagaccc 3609121 tccaaggcat aatattcgca ctgtacagga atcacaacgg aatccgaggc agtaagggca 3609181 ttaatcgtca gcaagcccaa tgacggcgga caatcaatga taatataatc ataattttgc 3609241 tttactgctt caagcgctct cttcaatctc acttctcttg atattgtagg aaccagctcg 3609301 atctcagccc ctgcaagctg aatcgtcgca ggaatcacat ccaagttctc tactgtcgtt 3609361 gctttaataa tatctattac atctgcatca tctactaaaa tatcgtacac acactgctct 3609421 acatcggctt tttcaatccc taatccgctt gtcgcatttc cctgcggatc aatatctacc 3609481 agcagaaccc ttttccctat gtaagccaaa catgccccaa ggttgacaga cgtcgttgtt 3609541 ttgccgaccc cgcctttttg gttcgtaatt gctatgattt ttcccacgat gtcacctact 3609601 ttcacatgaa catgtactat cttgcttcta ttctatcaaa aaaagattaa agcgtttcat 3609661 ttttttcatc attttgttcc gaatcagaag ggaaataatt gaaaattcaa gcacgcttta 3609721 tgctttctct tataaattct gcaatttcta tgtttttttg acttaaaaaa ggaatttctt 3609781 aaagaaaaaa agaagaagtc acagtacaga acgtggaaac aggatggtga gaaaatggtt 3609841 tatcaaacga agagagatgt acccgttacg ctgatgattg tgtttctcat attactgata 3609901 caagcagatg ccattgttcc ttttgtgctg ggaaatatga gagtttccgg ctggatcatt 3609961 tttattctgc tgactctttt aaatggactc atcatttgga gctttattga cctaaaatat 3610021 gtattgaagg aacaccatct gatcattaaa gccggattga tcaaacatca aattccttat 3610081 gaaaacatcg ataaagtcgt tcaaaaaaag aaactatggt ccggttttcg tctgatcggc 3610141 tctcgccatg ccatcacaat atattatcag gggggatggg gacatgcagt aatttcaccg 3610201 caaaaatctg aagaatttat ccacaagctc aaagaaaaga attctaatat aataatattc 3610261 actaaaagta agtgattacc ttttgttaaa aatataaaaa gctctcctgc ttttcaggag 3610321 agcttctatt ttggtatgcg aatcgttaat tgaatatatt cttcaaattc ttcttcttcc 3610381 gtattcaatt ttacaccgct gtcttccacc attgatagtg actggcgaat cgtgttcatc 3610441 gcaattcttg tatctctgct gaatgctttg cgtctcggct ttggctttct ctggccttgc 3610501 tccagcattt tcaccacgcg gtcttctgtc tgctttacat ttaaactttt ctcaataatc 3610561 tctgtgagca gtgtgacttg gagctcaggc tgtttcagcg gaatcagtgc tctggcatgg 3610621 cgctcggtga ttttcttctc cataatcgcc tcttggaccg gctgaggcag ctttaataac 3610681 cgaagcttat tcgcgattgt agactgccct tttcctaagc gctgtgcgag tgcctcctgt 3610741 gttaaatcat gcagctcaag cagcctagca taagcatgcg cttcctcaat agaagacagt 3610801 tcttcccgct gcaagttttc gattaacgcc acagaagcgg tttccgtgtc ggaaaaatcc 3610861 ttaataattg ccggaatctt ttcccactca agcgattgca ccgctctcca gcgtctttca 3610921 cctgcaatga gttcgtattg gccttcttct tctgtatgcc taacaacaat cggctgaata 3610981 atgccgtgtg tatgaatggt cattgctaac tctttgattt tttcatctga gaaaatggtg 3611041 cgtggctgaa aacggttggg aacgatagca tttaccggta tttccagaat ctcttctttg 3611101 tttgtatcat gttcagcaat ctccggctcc tgttccttct caccaagccc gaagaaacga 3611161 gagaatgaat gcttcatgta cctacaccac ctttaaaaac tgccattttt ataattctat 3611221 tttctcatgg tttttcctgc tgtacatcca tcaattttga tgaaaatatg atggtattgt 3611281 catatcaggc tgtctaaatt acccttcaat tggcgattta ttaggagttc ccggttttct 3611341 tggatacttc ttaggtgtat tttttatttt gcgtatcacc ataatattac gatcgctttc 3611401 ttcaataggc agcttaaaag aatggatatt ctcaagttct cctccaagcg tcgtgattgc 3611461 ttttttgcct gcattcagtt cttcttcagc tgatgcggct tttaaagcaa caaataaacc 3611521 gtttttcttc accagaggca agcaaagctc actcaaaaca gataatctcg caactgcgcg 3611581 cgccgtcaca atatcatagc tttcacgcac gtctttccgt tgcccgaacg tttcagctct 3611641 gtcatggcag aatgttgtat tctccaattg caaagcttca gacaactttt ctaaaaacgt 3611701 aatccgtttg tttagtgaat ccacgattgt gacatggagg tgcggaaagc atatttttat 3611761 cggcagactt ggaaaacccg ctcccgctcc aacatcacaa atcgtgttca cctgattgaa 3611821 gtcgacataa aaagcagctg taatggaatc ataaaaatgc tttaaataca cttctttttt 3611881 ctctgttatt gaagtcagat tgattttttc gttccattca accagcatgt cgtaatacag 3611941 ctcaaattgc tccagctgac ggggagaaag ggagatccct ttttccgcca aaccagaagt 3612001 gaattcttca atattcatgc cgtcatcctt tctactcggc tatcttcgca atgcgtccct 3612061 gctctaaata caccaataga attgaaatgt ccgccgggtt tacaccggaa atgcgggaag 3612121 cctgggcaac agacaaaggc cgtacatttt tcagtttttg acgcgcctcg gtcgcaatcc 3612181 ccttaattgc gtcataatca attcggtctg gaattttttt attttccatc ttcttcagtt 3612241 tttccacttg ctgaagagat ttttcaatat atccttcata tttcacttgg atttctactt 3612301 gttctgccac gtcttgagga accggcactt ctggcggcgc cagttttgtg actgtttcat 3612361 agttcatttc aggacgtttc atcaagtctg tgccgcgaac tccatctttc aattcgcttc 3612421 cgccaagaga acggatatat tcttgatttt ccggagacgg cttgataatt acagaatgaa 3612481 gacgtttttt ctccgcctcg atcgccgctt ttttcttctc aaaagccgca tagcgctcat 3612541 cagaaatcaa tccaatgcga tgtccgattt ctgtcagacg caaatcagca ttgtcatggc 3612601 gaagcagcaa tctgtattcc gcacgtgatg tcaaaagacg atatggctca ttggtacctt 3612661 ttgtcacaag gtcatcaatc agaacaccaa tataggcgtc agaacggctt agaattactt 3612721 cttcttttcc aagcgctttt cgtcctgcat tgattcccgc cataatccct tgtcccgcag 3612781 cttcttcata accggatgtt ccgttaattt ggcctgcagt ataaaggttt gtgatttttt 3612841 tggtttcaag tgtcggccat agctgtgtcg gtacgattgc atcatactcg atcgcatagc 3612901 cggctctcat catttgcacg ttttcaagtc caggaatcgt tgcaagcatt ctttgctgta 3612961 cgtcttctgg aagacttgta gataaacctt ggacatagac ttcctgtgta tttctgcctt 3613021 ccggctcaag gaagatttgg tgacgcggtt tatcattaaa acggacaact ttgtcttcaa 3613081 tggatgggca gtatcttggg cccgtacctt tgatcatacc ggaatacatc ggtgaacggt 3613141 gcaggttgct gtcaataatc tcatgtgtct cagggcttgt atatgtcagc cagcaaggga 3613201 gctgatctgt gatatattcc actgtttcat atgagaaagc gcgaggcaca tcgtcaccag 3613261 gctgaatttc cgttttgctg taatcaatcg tgtcgctttt aacgcgaggc ggcgtacctg 3613321 ttttaaaacg aacaaggtca aaaccgagtt cctccaaatg ctcagaaagc ttaatagaag 3613381 gctgctggtt attcgggccg cttgagtaag acagatcgcc aagaatgata cgtcctctta 3613441 aatatgtccc tgtcgtcatg acaactgctt tcgcacgata atgtgcgcct gtttgtgtaa 3613501 taacgcctcg gcattcgccg tcttcaacga tcagccgctc cacaattcct tgcagcaatg 3613561 ttaagtttgg ttctttttca agcgtatttt tcatttcgtg ctgatattgg aatttgtctg 3613621 cttgcgcacg caatgcacga accgcaggac cttttcctgt attcagcatt ctcatttgaa 3613681 tatgtgtttt atcgatgttt cttcccattt ctccgccgag cgcgtcaatt tcgcggacga 3613741 caatcccttt tgcggggccg ccgacagacg gattacatgg cataaatgca accatatcta 3613801 ggttgatggt caagacaagc gttttggcgc cttggcgtgc agatgcgagg gcagcctcaa 3613861 caccggcatg cccggcgcca atcacaatca catcgtattg gcctgcttca taccccatga 3613921 ttctagttcc tcctttaatt attttcctaa acagaattga gaaaagagct gatcaattaa 3613981 gctttcgtgg acagaatctc caatgatttc ccctaaaagc tcccagcatc ttgtaaggtc 3614041 aatttgcacc atgtcgatcg ggacatcctg ttcgatgccg ctaagcgcat cttcaatggc 3614101 gcgttttgct tgctgtaaaa tagtgatgtg acgtgtgttg ctgacataag tcagatcacc 3614161 gctttcaatg gcacccgtgt agaacagtga ttgaatcgct tcttccagat cattgatgcc 3614221 ttcctctttt aaaagagatg tcgtaacaac tggacgtcca ttggcaagct cacggacacg 3614281 ttcagtgtca atcttcggct caaggtcagt cttattcaaa atcacgataa catccatgcc 3614341 ctcaacggct tcaaaaagct tcacgtcttc ttcagaaagc tcttcactat aattaagcac 3614401 aagtaaaatc aggtccgctt cctttaggac ctggcgagaa cgttcaacac cgattcgctc 3614461 aacaatatcc tctgtttcac gaatacctgc tgtatcaacc agacgaagcg gaacgcccct 3614521 tacattcacg tattcctcaa tcacatcccg tgtcgttccg ggaatatcgg ttacaatggc 3614581 ttttgcctca tgaacgaggc tgttcagaag agatgatttt cctacgtttg gccggccgat 3614641 aatgacggta gaaagacctt cacgcaagat ttttccttgc tcagaagtcc tcagcagcgt 3614701 ctcaatttcc tttttcacgg cggttgcctt ttcgactaaa atctgatgcg tcatttcctc 3614761 tacatcatca tactccggat aatcaatatt cacctcaaca tgggccagtg tttctaaaat 3614821 ctcactgcgc aaacggcgca ccaaagcaga aagacgccct tccatttgat tcatagcaac 3614881 gttcattgcc cggtccgttt tcgctctgat taagtccata accgcttccg cctgtgaaag 3614941 atcgattcgg ccgtttaaaa acgcacgttt cgtaaattca ccaggctctg ccagtctcgc 3615001 tccctctctc aatgcaagct gaagcacttg gttcacagtc acaattcccc cgtgacagtt 3615061 aatctcgatg acatcttctc gtgtaaaagt tctcggcgct tttaacactg ataccattac 3615121 ttcctcaacg acacgatccg aaggtctgtc tacgatatga ccataatgaa tcgtatgtga 3615181 ttcgaccgag ctgagtgttt tccccttcgg tcccttataa attttatctg cgatttgaat 3615241 ggcttctggt ccgctcaacc gtacaatcgc aatcgcgcct tctcccatcg gtgtggaaat 3615301 tgccgcaatt gtatccatgt tgttcacctc tctttactta tacttcatct atataaaaaa 3615361 atttttatta tgccaaaact aaaagataac atagtttggt tcgaagtgga agatttgtta 3615421 tccacagaaa tagaaattcg tcccttatta ctttaactta tccacatgtg aataacaatt 3615481 aattttattt cctgaacttc ctttttatca acaggataca cctaaaaaga aaaaacttaa 3615541 acggcaaaac cttgatatta ctaggaaaag tagatttttc ggatacaaaa aaaccgaaat 3615601 ccaattttta tcggacttcg gttttatgct atcttttatg ggaaataacg agatgacgat 3615661 tttcgccttc acccattgaa tatgttttga tctggtggtt tgcatatcca gaaagagtat 3615721 cgtgaataat ttttctttcg ctggacggca tgggctcaag ctggatggat tttttcgttt 3615781 tcaaaacctg gtcagcaagc ttgatggcca gctggctcag tgtttctttt cttttcaaac 3615841 gatagttttc tgcatccacc gtcacatttt tatattggcc tggataacgg ttaagggcaa 3615901 gctgtgtcaa agtttcaagg gcgtttaaag tttgtcctct tttcccaatc aacaatgctg 3615961 ccttttcacc tgttatatga tatctcactg tctttttgct ttcttgaaca gtcacatcag 3616021 acttcccggc aatggcttcg gcaatcgttt gaagatataa cttcgcttgc tgaatcggat 3616081 caatcttttc aaccagcttt acgatcgcag gctttttacc gaaaataccg agaaaccctt 3616141 tgtttccctc ttcaataaca gtaatttcta ccttatcctt cgttaatccc aactcttgca 3616201 atccggactg tactgcttca tcgacatttc gccctgcagc agtcacattc ctcacttttt 3616261 ctttcctccg gctttttgcg gctcaggatt ttttttaata tcaggtcctt taatgaggaa 3616321 agtttgcgca atcataaaca agttaccaac tacccaataa agagaaagag ccgccgggaa 3616381 gttgatcgca aatacgataa tcataattgg cataatccaa agcatcatcg ccatttgcgg 3616441 attttgctgc gcattgccag ccatcatcag tttttgctga acaaatgtag cgacaccggc 3616501 aacgatagga agaatatagt aaggatcttt ttctcctaag tcaaaccata agaagctatg 3616561 ctctgaaatc gcctgggttc tcatgatcgc atgatagaat ccaattaaaa tcggcatctg 3616621 gatcaaaatc gggaaacatc ccgccaatgg attgacacca tgcttttgga ataaagccat 3616681 tgtttcctgt tgaagctttt gctgcgtttt ttgatccttt gagctgtatt tttctttaag 3616741 cttttgcatt tccggctgta aagcctgcat cgctttcgaa cttctcagct gcttaatcat 3616801 cagcggtaaa attaataaac gaattaaaat ggtaactaga ataattgaaa gcccgtagtt 3616861 atctcccgtc aatttcgcta catacgtaat gagctcagac aatggatata ctacgtactt 3616921 gtcccagaaa tgcggactat ctgcagtgat cggctctttc acactcgagc atccagccaa 3616981 aagcatgaat acgccaacca tacttaatag caaccctatt ctccttttca acaacatttc 3617041 ctcctataat taatctttac actcttttat tgcaaagcat acttgtatgt attttagcat 3617101 ctttcagttt taaatggtgt ctttttctga tcaaccagaa aggaagcgct tttaaaagtt 3617161 gtaagaaagc agtggtgatg cctactttga cgaagatttc ttatataatg aagactttct 3617221 gaatagatgc tgcagacttt ttttcgtttc ctcatatgtc agctggctcg ccggttttct 3617281 ggcaataatg atgtaatcct tttccttcag tctctctttc tcttcaagaa aggcctgccg 3617341 aatcaaacgt ttgatccgat ttcgcatcac agcattgcca atttttttgc tgacggaaag 3617401 cccgacacgc agttcatcat tttcaggctg atcaagcgta tataagacaa actggcggtt 3617461 tgcaactgat gtcccatgtt taaacacttt ttgaaaatct tcatttttct ttaaacgatt 3617521 tcgcttcttc aaatgactca ctccgatact ggctggcaga aacttttaaa atttattatg 3617581 aacatgagat gcatctgaac caggaagcat gccccggttc attacgcatc acatctatct 3617641 tttcccataa cgtgaaaaaa gaccactgac attattcagt ggcctaagct gataatactt 3617701 ttctgccttt gcggcgacgg cgtgctaaaa ctagacgacc gttttttgaa ctcatacggc 3617761 ttctgaagcc atgaactttg ctgcgtttac ggttattcgg ttggaatgtt cttttcattt 3617821 atgacacctc cctcgaggaa tagctgttaa agacagtctt acttattata tttgcgttac 3617881 ctattcattg tcaacttcac tagtgctttt atttcttgca accataatag gataccatac 3617941 cttttcaact ttcgaaacct tattttttag attccttaat tttacggaaa aaagacaaat 3618001 tcaaacaatt tgcccctaaa atcacgcatg tggatatctt tttcggcttt ttttagtatc 3618061 cacagaggtt atcgacaaca ttttcacatt accaacccct gtggacaagg ttttttcaac 3618121 aggttgtccg ctttgtggat aagattgtga caaccattgc aagctctcgt ttattttggt 3618181 attatatttg tgttttaact cttgattact aatcctacct ttcctcttta tccacaaagt 3618241 gtggataagt tgtggattga tttcacacag cttgtgtaga aggttgtcca caagttgtga 3618301 aatttgtcga aaagctattt atctactata ttatatgttt tcaacattta atgtgtacga 3618361 atggtaagcg ccatttgctc tttttttgtg ttctataaca gagaaagacg ccattttcta 3618421 agaaaaggag ggacgtgccg gaag //